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Sample records for areas mediating motion-induced

  1. Gamma-aminobutyric acid (GABA) and neuropeptides in neural areas mediating motion-induced emesis

    Science.gov (United States)

    Damelio, F.; Daunton, Nancy G.; Fox, Robert A.

    1991-01-01

    Immunocytochemical methods were employed to localize the neurotransmitter amino acid gamma-aminobutyric acid and the neuropeptides substance P and Met-enkephalin in the area postrema (AP), area subpostrema (ASP), nucleus of the tractus solitarius (NTS), dorsal motor nucleus of the vagus nerve (DMNV), and lateral vestibular nucleus (LVN). Glutamic acid decarboxylase immunoreactive (GAD-IR) terminals and fibers were observed in the AP and particularly in the ASP. A gradual decrease in the density of terminals was seen towards the solitary complex. The DMNV revealed irregularly scattered GAD-IR terminals within the neuropil or closely surrounding neuronal cell bodies. The LVN, particularly the dorsal division, showed numerous axon terminals which were mostly localize around large neurons and their proximal dendrites. Substance P immunoreactive (SP-IR) terminals and fibers showed high density in the solitary complex, in particular within the lateral division. The ASP showed medium to low density of SP-IR fibers and terminals. The AP exhibited a small number of fibers and terminals irregularly distributed. The DMNV revealed a high density of SP-IR terminals and fibers that were mainly concentrated in the periphery. Very few terminals were detected in the LVN. Met-enkephalin immunoreactive (Met-Enk-IR) fibers and terminals showed high density and uniform distribution in the DMNV. Scattered terminals and fibers were observed in the AP, ASP, and NTS (particularly the lateral division). The very few fibers were observed in the LVN surrounded the neuronal cell bodies. The present report is part of a study designed to investigate the interaction between neuropeptides and conventional neurotransmitters under conditions producing motion sickness and in the process of sensory-motor adaptation.

  2. Immunocytochemical localization of glutamic acid decarboxylase (GAD) and substance P in neural areas mediating motion-induced emesis: Effects of vagal stimulation on GAD immunoreactivity

    Science.gov (United States)

    Damelio, F.; Gibbs, M. A.; Mehler, W. R.; Daunton, Nancy G.; Fox, Robert A.

    1991-01-01

    Immunocytochemical methods were employed to localize the neurotransmitter amino acid gamma-aminobutyric acid (GABA) by means of its biosynthetic enzyme glutamic acid decarboxylase (GAD) and the neuropeptide substance P in the area postrema (AP), area subpostrema (ASP), nucleus of the tractus solitarius (NTS), and gelatinous nucleus (GEL). In addition, electrical stimulation was applied to the night vagus nerve at the cervical level to assess the effects on GAD-immunoreactivity (GAR-IR). GAD-IR terminals and fibers were observed in the AP, ASP, NTS, and GEL. They showed pronounced density at the level of the ASP and gradual decrease towards the solitary complex. Nerve cells were not labelled in our preparations. Ultrastructural studies showed symmetric or asymmetric synaptic contracts between labelled terminals and non-immunoreactive dendrites, axons, or neurons. Some of the labelled terminals contained both clear- and dense-core vesicles. Our preliminary findings, after electrical stimulation of the vagus nerve, revealed a bilateral decrease of GAD-IR that was particularly evident at the level of the ASP. SP-immunoreactive (SP-IR) terminals and fibers showed varying densities in the AP, ASP, NTS, and GEL. In our preparations, the lateral sub-division of the NTS showed the greatest accumulation. The ASP showed medium density of immunoreactive varicosities and terminals and the AP and GEL displayed scattered varicose axon terminals. The electron microscopy revealed that all immunoreactive terminals contained clear-core vesicles which make symmetric or asymmetric synaptic contact with unlabelled dendrites. It is suggested that the GABAergic terminals might correspond to vagal afferent projections and that GAD/GABA and substance P might be co-localized in the same terminal allowing the possibility of a regulated release of the transmitters in relation to demands.

  3. Attentional modulation of motion-induced blindness

    Institute of Scientific and Technical Information of China (English)

    GENG HaiYan; SONG QianLan; LI YunFeng; XU Shan; ZHU Ying

    2007-01-01

    When a global moving pattern is superimposed on high-contrast stationary or slowly moving stimuli,the stimuli can be perceived as disappearing and reappearing alternately for periods of several seconds. This visual illusory phenomenon was named "motion-induced blindness" (MIB) in recent literature. So far there is no consensus on the mechanism of MIB, especially on the role of attention in this phenomenon. To examine the effect of spatial attention on MIB, the present study manipulated the participants' spatial attention by asking them to respond to two targets simultaneously presented in bilateral visual fields (the divided-attention condition) or only respond to one of them (the focused-attention condition). A central arrow was presented as an endogenous cue to index the target visual field in the focused-attention condition, while a point was presented instead in the divided-attention condition. The results show that the percentage of accumulated invisibility period was larger for the targets in the focused-attention condition than for those in the divided-attention condition.This effect of attentionis significant in upper visual field (UVF) and left lower visual field (left LVF); that is, this effect shows a hemispheric asymmetry in LVF but not in UVF. Furthermore, the percentage of accumulated invisibility period was larger for targets in left LVF than for those in right LVF in the focused-attention condition, but no hemispheric asymmetry was found in the divided-attention condition.In addition, the increased percentage of accumulated invisibility period in the focused-attention condition originated merely in the enhancement of the mean phase duration of disappearance in LVF, while the disappearance occurred more frequently and lasted longer for each occurrence, which led to an increase in the total invisibility period, in the focused- than divided-attention condition in UVF. These results suggest that the modulation of spatial attention on MIB has different

  4. Attentional influences on the dynamics of motion-induced blindness

    OpenAIRE

    Scholvinck, M. L.; Rees, G.

    2009-01-01

    Motion-induced blindness (MIB) is a visual phenomenon in which a highly salient, peripheral, visual target spontaneously disappears from visual awareness (and subsequently reappears) when superimposed on a globally moving background of distracters. Here, we investigated the influence of attention on these fluctuations in perception in two experiments. In the first experiment, directing spatial attention to the MIB target (and thus away from the distracters) led to an increased probability of ...

  5. Radiometric resolution of motion-induced synthetic aperture radiometer

    OpenAIRE

    Hyuk, Park; Camps Carmona, Adriano José; Choi, Min Gyu; Kim, Yong-Hoon

    2011-01-01

    The radiometric resolution of a motion-induced synthetic aperture radiometer (MISAR) is analytically obtained from the standard deviation of a baseline response, an observation scenario, and the imaging method of the MISAR. The intrinsic long integration time given by the whole dwell time on moving platforms improves the radiometric resolution compared with the snapshot resolution of other nominal synthetic aperture radiometers. In addition, it is illustrated that the MISAR imaging hold...

  6. Mediation a Conflict Solving Modality in the Banking Area

    Directory of Open Access Journals (Sweden)

    George MĂGUREANU

    2015-08-01

    Full Text Available The overall objective of the paper is a current topic of a real interest for the reasonable solution of the conflicts which emerge in the banking area. Using the method resulted from a detailed analysis of the field literature and the judiciary practice, the article manages to identify the amplitude and generic principles of solving the litigations in the commercial area through alternative methods to the state justice, overcharged with cases, within the context of the European Union’s regulations and implicitly at the national level. Therefore, we shall perform an analysis of the following objectives: the concept of conflict solving through alternative methods to the state justice, reasonable solution of the conflicts with the possibility of preserving the relations between the partners, the application of the privacy principle. Mediation in the banking area aims at solving the conflicts between the credit institutions, banks or the non-banking institutions and their customers by a person with a special training in the mediation area, independent from the two parties, through a more simplified procedure, so that the relation between the credit unit and its customer should remain a partnership. The paper may contribute to the development of the legislation on the more rapid resolution of this type of litigations; it is useful for the law practitioners: judges, lawyers, counsels, teaching staff and also for the business people in the banking area.

  7. Motion-induced dose artifacts in helical tomotherapy

    Science.gov (United States)

    Kim, Bryan; Chen, Jeff; Kron, Tomas; Battista, Jerry

    2009-10-01

    Tumor motion is a particular concern for a complex treatment modality such as helical tomotherapy, where couch position, gantry rotation and MLC leaf opening all change with time. In the present study, we have investigated the impact of tumor motion for helical tomotherapy, which could result in three distinct motion-induced dose artifacts, namely (1) dose rounding, (2) dose rippling and (3) IMRT leaf opening asynchronization effect. Dose rounding and dose rippling effects have been previously described, while the IMRT leaf opening asynchronization effect is a newly discovered motion-induced dose artifact. Dose rounding is the penumbral widening of a delivered dose distribution near the edges of a target volume along the direction of tumor motion. Dose rippling is a series of periodic dose peaks and valleys observed within the target region along the direction of couch motion, due to an asynchronous interplay between the couch motion and the longitudinal component of tumor motion. The IMRT leaf opening asynchronization effect is caused by an asynchronous interplay between the temporal patterns of leaf openings and tumor motion. The characteristics of each dose artifact were investigated individually as functions of target motion amplitude and period for both non-IMRT and IMRT helical tomotherapy cases, through computer simulation modeling and experimental verification. The longitudinal dose profiles generated by the simulation program agreed with the experimental data within ±0.5% and ±1.5% inside the PTV region for the non-IMRT and IMRT cases, respectively. The dose rounding effect produced a penumbral increase up to 20.5 mm for peak-to-peak target motion amplitudes ranging from 1.0 cm to 5.0 cm. Maximum dose rippling magnitude of 25% was calculated, when the target motion period approached an unusually high value of 10 s. The IMRT leaf opening asynchronization effect produced dose differences ranging from -29% to 7% inside the PTV region. This information on

  8. Verification of motion induced thread effect during tomotherapy using gel dosimetry

    International Nuclear Information System (INIS)

    The purpose of the study was to evaluate how breathing motion during tomotherapy (Accuray, CA, USA) treatment affects the absorbed dose distribution. The experiments were carried out using gel dosimetry and a motion device simulating respiratory-like motion (HexaMotion, ScandiDos, Uppsala, Sweden). Normoxic polyacrylamide gels (nPAG) were irradiated, both during respiratory-like motion and in a static mode. To be able to investigate interplay effects the static absorbed dose distribution was convolved with the motion function and differences between the dynamic and convolved static absorbed dose distributions were interpreted as interplay effects. The expected dose blurring was present and the interplay effects formed a spiral pattern in the lower dose volume. This was expected since the motion induced affects the preset pitch and the theoretically predicted thread effect may emerge. In this study, the motion induced thread effect was experimentally verified for the first time

  9. Motion-induced phase error estimation and correction in 3D diffusion tensor imaging.

    Science.gov (United States)

    Van, Anh T; Hernando, Diego; Sutton, Bradley P

    2011-11-01

    A multishot data acquisition strategy is one way to mitigate B0 distortion and T2∗ blurring for high-resolution diffusion-weighted magnetic resonance imaging experiments. However, different object motions that take place during different shots cause phase inconsistencies in the data, leading to significant image artifacts. This work proposes a maximum likelihood estimation and k-space correction of motion-induced phase errors in 3D multishot diffusion tensor imaging. The proposed error estimation is robust, unbiased, and approaches the Cramer-Rao lower bound. For rigid body motion, the proposed correction effectively removes motion-induced phase errors regardless of the k-space trajectory used and gives comparable performance to the more computationally expensive 3D iterative nonlinear phase error correction method. The method has been extended to handle multichannel data collected using phased-array coils. Simulation and in vivo data are shown to demonstrate the performance of the method. PMID:21652284

  10. Freezing motion-induced dephasing in an atomic-ensemble quantum memory

    CERN Document Server

    Jiang, Yan; Bao, Xiao-Hui; Pan, Jian-Wei

    2016-01-01

    Motion-induced dephasing is a dominant decoherence mechanism for atom-gas quantum memories. In this paper, we develop a new coherent manipulation technique which enables arbitrary engineering of the spin-wave momentum with neglectable noise. By zeroing the spin-wave momentum, motion-induced dephasing can be frozen completely. We experimentally demonstrate this scheme with laser-cooled atoms in a DLCZ configuration. By applying the freezing pulses, memory lifetime gets extended significantly to the limit of atom cloud expansion and does not depend on the detection angle anymore. The observed high cross-correlation above 20 proves that high-fidelity memory operation is well preserved after coherent manipulation.

  11. Motion-induced blindness and Troxler fading: common and different mechanisms

    OpenAIRE

    Bonneh, Yoram S.; Donner, Tobias H.; Alexander Cooperman; Heeger, David J.; Dov Sagi

    2014-01-01

    Extended stabilization of gaze leads to disappearance of dim visual targets presented peripherally. This phenomenon, known as Troxler fading, is thought to result from neuronal adaptation. Intense targets also disappear intermittently when surrounded by a moving pattern (the "mask"), a phenomenon known as motion-induced blindness (MIB). The similar phenomenology and dynamics of these disappearances may suggest that also MIB is, likewise, solely due to adaptation, which may be amplified by the...

  12. Action spectroscopy for single-molecule motion induced by vibrational excitation with a scanning tunneling microscope

    OpenAIRE

    Ueba, H.; Persson, B.N.J.

    2007-01-01

    We propose an action spectroscopy for single-molecule motion induced by vibrational excitation with a scanning tunneling microscope (STM). Calculations of the inelastic tunneling current for excitation of the C-O stretch mode of the CO molecule on metal surfaces are combined with a theory which describes how the energy in the vibrational mode is transferred to a reaction coordinate mode to overcome the activation barrier. The calculated rate for CO hopping on Pd (110) as a function of the bia...

  13. Patient-specific quantification of respiratory motion-induced dose uncertainty for step-and-shoot IMRT of lung cancer

    OpenAIRE

    Li, Heng; Park, Peter; Liu, Wei; Matney, Jason; Liao, Zhongxing; Balter, Peter; Li, Yupeng; Zhang, Xiaodong; Li, Xiaoqiang; Zhu, X. Ronald

    2013-01-01

    Purpose: The objective of this study was to quantify respiratory motion-induced dose uncertainty at the planning stage for step-and-shoot intensity-modulated radiation therapy (IMRT) using an analytical technique.

  14. Freezing motion-induced dephasing for single spin-state stored in atomic ensemble

    Science.gov (United States)

    Jiang, Yan; Jun, Rui; Bao, Xiao-Hui; Pan, Jian-Wei

    2016-05-01

    Atomic-ensemble quantum memories are well considered as a promising approach of long-distance quantum communication and computation for strong light-matter interaction. While the storage lifetime is limited by the motion-induced dephasing. Spin-echo technique, increasing wavelength of spin-wave, as well as optical lattice are used commonly to overcome this dephasing process. However, these techniques either need extremely high fidelity of echo pulse or put high restriction on filter and experimental complexity. In this poster, we demonstrate a convenient technique to freeze the motion-induced dephasing without population inversion and can be used in large storage angles. Combined with ``clock states'', the lifetime is extended by one order of magnitude to the limit of the thermal expansion. What's more, high non-classical correlation above 20 has been achieved to guarantee the memory in quantum regime.By making the advance from passive engineering to coherent manipulation of single spin-wave states, our work enriches the experimental toolbox of harnessing atomic ensembles for high-performance quantum memories, especially for holographic quantum memories where many spin-waves with different wave-vectors are used.

  15. 8-OH-DPAT does not interfere with habituation to motion-induced emesis in cats

    Science.gov (United States)

    Lucot, James B.; Crampton, George H.

    1991-01-01

    Experiments were performed to determine if suppression of motion-induced emesis (motion sickness) by 8-OH-DPAT altered the development or retention of habituation to the motion stimulus. Cats received 8-OH-DPAT followed by provocative motion on three consecutive treatment days. A drug-free test on the fourth day resulted in an incidence of emesis that was not different from that obtained on the fourth consecutive day of drug-free motion testing. Three consecutive days of treatment with 8-OH-DPAT without motion had no effect on the incidence of motion sickness on the fourth day. It was concluded that suppression of motion sickness by 8-OH-DPAT does not alter the acquisition or retention of habituation.

  16. Motion-induced blindness and Troxler fading: common and different mechanisms.

    Directory of Open Access Journals (Sweden)

    Yoram S Bonneh

    Full Text Available Extended stabilization of gaze leads to disappearance of dim visual targets presented peripherally. This phenomenon, known as Troxler fading, is thought to result from neuronal adaptation. Intense targets also disappear intermittently when surrounded by a moving pattern (the "mask", a phenomenon known as motion-induced blindness (MIB. The similar phenomenology and dynamics of these disappearances may suggest that also MIB is, likewise, solely due to adaptation, which may be amplified by the presence of the mask. Here we directly compared the dependence of both phenomena on target contrast. Observers reported the disappearance and reappearance of a target of varying intensity (contrast levels: 8%-80%. MIB was induced by adding a mask that moved at one of various different speeds. The results revealed a lawful effect of contrast in both MIB and Troxler fading, but with opposite trends. Increasing target contrast increased (doubled the rate of disappearance events for MIB, but decreased the disappearance rate to half in Troxler fading. The target mean invisible period decreased equally strongly with target contrast in MIB and in Troxler fading. The results suggest that both MIB and Troxler are equally affected by contrast adaptation, but that the rate of MIB is governed by an additional mechanism, possibly involving antagonistic processes between neuronal populations processing target and mask. Our results link MIB to other bi-stable visual phenomena that involve neuronal competition (such as binocular rivalry, which exhibit an analogous dependency on the strength of the competing stimulus components.

  17. Motion-induced blindness and Troxler fading: common and different mechanisms.

    Science.gov (United States)

    Bonneh, Yoram S; Donner, Tobias H; Cooperman, Alexander; Heeger, David J; Sagi, Dov

    2014-01-01

    Extended stabilization of gaze leads to disappearance of dim visual targets presented peripherally. This phenomenon, known as Troxler fading, is thought to result from neuronal adaptation. Intense targets also disappear intermittently when surrounded by a moving pattern (the "mask"), a phenomenon known as motion-induced blindness (MIB). The similar phenomenology and dynamics of these disappearances may suggest that also MIB is, likewise, solely due to adaptation, which may be amplified by the presence of the mask. Here we directly compared the dependence of both phenomena on target contrast. Observers reported the disappearance and reappearance of a target of varying intensity (contrast levels: 8%-80%). MIB was induced by adding a mask that moved at one of various different speeds. The results revealed a lawful effect of contrast in both MIB and Troxler fading, but with opposite trends. Increasing target contrast increased (doubled) the rate of disappearance events for MIB, but decreased the disappearance rate to half in Troxler fading. The target mean invisible period decreased equally strongly with target contrast in MIB and in Troxler fading. The results suggest that both MIB and Troxler are equally affected by contrast adaptation, but that the rate of MIB is governed by an additional mechanism, possibly involving antagonistic processes between neuronal populations processing target and mask. Our results link MIB to other bi-stable visual phenomena that involve neuronal competition (such as binocular rivalry), which exhibit an analogous dependency on the strength of the competing stimulus components. PMID:24658600

  18. Centre-of-mass motion-induced decoherence and entanglement generation in a hybrid quantum repeater

    International Nuclear Information System (INIS)

    Quantum communication over long distances relies on the ability to create entanglement between two remote quantum nodes. Recent proposals aiming at experimental realization propose a hybrid quantum repeater setup where two distant material qubits are entangled by light–matter interaction. Motivated by these developments, we investigate possible decoherence effects originating from the centre-of-mass motion of the spatially well-separated trapped qubits. Within the Lamb–Dicke regime we use photon exchange involving coherent states of the radiation field to entangle the two material qubits. Optimal generalized photonic field measurements are used to achieve entangled qubit pairs with high fidelities and high success probabilities. We demonstrate that the quality of the achievable two-qubit entanglement crucially depends on the trap frequencies involved. Furthermore, dynamical decoupling schemes are proposed which are capable of suppressing centre-of-mass motion-induced decoherence effects significantly and which involve only local operations acting on the spatially well-separated material qubits. (paper)

  19. Motion-induced blindness continues outside visual awareness and without attention.

    Science.gov (United States)

    Dieter, Kevin C; Tadin, Duje; Pearson, Joel

    2015-01-01

    Visual phenomena demonstrating striking perceptual disappearances of salient stimuli have fascinated researchers because of their utility in identifying neural processes that underlie subjective visibility and invisibility. Motion-induced blindness (MIB) is appealing for such purposes because it, like a class of ostensibly related paradigms such as binocular rivalry, features periods of unequivocal subjective disappearances despite constant physical stimulation. It remains unclear, however, exactly how the mechanisms that cause MIB are related to subjectively observed fluctuations in visual awareness. To address this question, we used continuous flash suppression (CFS) to present the MIB stimulus outside visual awareness. Results indicated that MIB occasionally reappeared from suppression with its salient yellow target absent. To quantify this observation, we measured reaction times (RTs) to detect the yellow dot target following visible or perceptually suppressed MIB and indeed found no difference in RTs between these conditions. We also provide evidence that MIB fluctuations can occur without attention. In sum, these experiments indicate that MIB fluctuations are effectively changes in stimulus strength, which under typical conditions result in unmistakable subjective disappearances, but are not inherently fluctuations in stimulus visibility. More broadly, these results challenge the assumed privileged link between bistable stimuli and visual awareness. PMID:26138079

  20. Pulsed Rydberg four-wave mixing with motion-induced dephasing in a thermal vapor

    CERN Document Server

    Chen, Yi-Hsin; Löw, Robert; Pfau, Tilman

    2015-01-01

    We report on time-resolved pulsed four-wave mixing (FWM) signals in a thermal Rubidium vapor involving a Rydberg state. We observe FWM signals with dephasing times up to 7 ns, strongly dependent on the excitation bandwidth to the Rydberg state. The excitation to the Rydberg state is driven by a pulsed two-photon transition on ns time scales. Combined with a third cw de-excitation laser, a strongly directional and collective emission is generated according to a combination of the phase matching effect and averaging over Doppler classes. In contrast to a previous report [1] using off-resonant FWM, at a resonant FWM scheme we observe additional revivals of the signal shortly after the incident pulse has ended. We infer that this is a revival of motion-induced constructive interference between the coherent emissions of the thermal atoms. The resonant FWM scheme reveals a richer temporal structure of the signals, compared to similar, but off-resonant excitation schemes. A simple explanation lies in the selectivity...

  1. Simulation by using the lattice Boltzmann method of microscopic particle motion induced by artificial cilia

    Science.gov (United States)

    Alapati, Suresh; Che, Woo Seong; Mannoor, Madhusoodanan; Suh, Yong Kweon

    2016-06-01

    In this paper, we present the results obtained from the simulation of particle motion induced by the fluid flow driven by an array of beating artificial cilia inside a micro-channel. A worm-like-chain model is used to simulate the elastic cilia, and the lattice Boltzmann equation is used to compute the fluid flow. We employ a harmonic force at the extreme tip of each cilium to actuate it. Our simulation methods are first validated by applying them to the motion of a single cilium and a freely falling sphere. After validation, we simulate the fluid flow generated by an array of beating cilia and find that a maximum flow rate is achieved at an optimum sperm number. Next, we simulate the motion of a neutrally buoyant spherical particle at this optimum sperm number by tracking the particle motion with a smoothed profile method. We address the effect of the following parameters on the particle velocity: the gap between cilia and particle, the particle size, the cilia density, and the presence of an array of intermediate particles.

  2. Hypoxia-induced hypothermia mediated by GABA in the rostral parapyramidal area of the medulla oblongata.

    Science.gov (United States)

    Osaka, T

    2014-05-16

    Hypoxia evokes a regulated decrease in the body core temperature (Tc) in a variety of animals. The neuronal mechanisms of this response include, at least in part, glutamatergic activation in the lateral preoptic area (LPO) of the hypothalamus. As the sympathetic premotor neurons in the medulla oblongata constitute a cardinal relay station in the descending neuronal pathway from the hypothalamus for thermoregulation, their inhibition can also be critically involved in the mechanisms of the hypoxia-induced hypothermia. Here, I examined the hypothesis that hypoxia-induced hypothermia is mediated by glutamate-responsive neurons in the LPO that activate GABAergic transmission in the rostral raphe pallidus (rRPa) and neighboring parapyramidal region (PPy) of the medulla oblongata in urethane-chloralose-anesthetized, neuromuscularly blocked, artificially ventilated rats. Unilateral microinjection of GABA (15nmol) into the rRPa and PPy regions elicited a prompt increase in tail skin temperature (Ts) and decreases in Tc, oxygen consumption rate (VO2), and heart rate. Next, when the GABAA receptor blocker bicuculline methiodide (bicuculline methiodide (BMI), 10pmol) alone was microinjected into the rRPa, it elicited unexpected contradictory responses: simultaneous increases in Ts, VO2 and heart rate and a decrease in Tc. Then, when BMI was microinjected bilaterally into the PPy, no direct effect on Ts was seen; and thermogenic and tachycardic responses were slight. However, pretreatment of the PPy with BMI, but not vehicle saline, greatly attenuated the hypothermic responses evoked by hypoxic (10%O2-90%N2, 5min) ventilation or bilateral microinjections of glutamate (5nmol, each side) into the LPO. The results suggest that hypoxia-induced hypothermia was mediated, at least in part, by the activation of GABAA receptors in the PPy. PMID:24607346

  3. Patient-specific quantification of respiratory motion-induced dose uncertainty for step-and-shoot IMRT of lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Li, Heng; Park, Peter; Liu, Wei; Matney, Jason; Balter, Peter; Zhang, Xiaodong; Li, Xiaoqiang; Zhu, X. Ronald [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States); Liao, Zhongxing [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States); Li, Yupeng [Applied Research, Varian Medical Systems, Palo Alto, California 94304 (United States)

    2013-12-15

    Purpose: The objective of this study was to quantify respiratory motion-induced dose uncertainty at the planning stage for step-and-shoot intensity-modulated radiation therapy (IMRT) using an analytical technique.Methods: Ten patients with stage II/III lung cancer who had undergone a planning four-dimensional (4D) computed tomographic scan and step-and-shoot IMRT planning were selected with a mix of motion and tumor size for this retrospective study. A step-and-shoot IMRT plan was generated for each patient. The maximum and minimum doses with respiratory motion were calculated for each plan, and the mean deviation from the 4D dose was calculated, taking delivery time, fractionation, and patient breathing cycle into consideration.Results: For all patients evaluated in this study, the mean deviation from the 4D dose in the planning target volume (PTV) was <2.5%, with a standard deviation <1.2%, and maximum point dose variation from the 4D dose was <6.2% in the PTV assuming delivery dose rate of 200 MU/min and patient breathing cycle of 8 s. The motion-induced dose uncertainty is a function of motion, fractionation, MU (plan modulation), dose rate, and patient breathing cycle.Conclusions: Respiratory motion-induced dose uncertainty varies from patient to patient. Therefore, it is important to evaluate the dose uncertainty on a patient-specific basis, which could be useful for plan evaluation and treatment strategy determination for selected patients.

  4. Patient-specific quantification of respiratory motion-induced dose uncertainty for step-and-shoot IMRT of lung cancer

    International Nuclear Information System (INIS)

    Purpose: The objective of this study was to quantify respiratory motion-induced dose uncertainty at the planning stage for step-and-shoot intensity-modulated radiation therapy (IMRT) using an analytical technique.Methods: Ten patients with stage II/III lung cancer who had undergone a planning four-dimensional (4D) computed tomographic scan and step-and-shoot IMRT planning were selected with a mix of motion and tumor size for this retrospective study. A step-and-shoot IMRT plan was generated for each patient. The maximum and minimum doses with respiratory motion were calculated for each plan, and the mean deviation from the 4D dose was calculated, taking delivery time, fractionation, and patient breathing cycle into consideration.Results: For all patients evaluated in this study, the mean deviation from the 4D dose in the planning target volume (PTV) was <2.5%, with a standard deviation <1.2%, and maximum point dose variation from the 4D dose was <6.2% in the PTV assuming delivery dose rate of 200 MU/min and patient breathing cycle of 8 s. The motion-induced dose uncertainty is a function of motion, fractionation, MU (plan modulation), dose rate, and patient breathing cycle.Conclusions: Respiratory motion-induced dose uncertainty varies from patient to patient. Therefore, it is important to evaluate the dose uncertainty on a patient-specific basis, which could be useful for plan evaluation and treatment strategy determination for selected patients

  5. A template-free solvent-mediated synthesis of high surface area boron nitride nanosheets for aerobic oxidative desulfurization.

    Science.gov (United States)

    Wu, Peiwen; Zhu, Wenshuai; Chao, Yanhong; Zhang, Jinshui; Zhang, Pengfei; Zhu, Huiyuan; Li, Changfeng; Chen, Zhigang; Li, Huaming; Dai, Sheng

    2016-01-01

    Hexagonal boron nitride nanosheets (h-BNNs) with rather high specific surface area (SSA) are important two-dimensional layer-structured materials. Here, a solvent-mediated synthesis of h-BNNs revealed a template-free lattice plane control strategy that induced high SSA nanoporous structured h-BNNs with outstanding aerobic oxidative desulfurization performance. PMID:26502800

  6. The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking.

    Science.gov (United States)

    Li, Jin; Cui, Yue; Wu, Karen; Liu, Bing; Zhang, Yun; Wang, Chao; Jiang, Tianzi

    2015-08-15

    Novelty seeking (NS) is a personality trait important for adaptive functioning, but an excessive level of NS has been linked to psychiatric disorders such as ADHD and substance abuse. Previous research has investigated separately the neural and genetic bases of the NS trait, but results were mixed and neural and genetic bases have yet to be examined within the same study. In this study, we examined the interrelationships among the dopamine beta-hydroxylase (DBH) gene, brain structure, and the NS trait in 359 healthy Han Chinese subjects. We focused on the DBH gene because it encodes a key enzyme for dopamine metabolism, NS is believed to be related to the dopaminergic system and has been reported associated with DBH variation. Results showed a significant positive association between the cortical surface area of the left insula and NS score. Furthermore, the DBH genetic polymorphism at the SNP rs7040170 was strongly associated with both the surface area of the left insula and NS score, with G carriers having a larger left insula surface area and a higher NS score than AA homozygotes. Subsequent path analysis suggested that the insula partially mediated the association between the DBH gene and the NS trait. Our data provided the first evidence for the involvement of the insula in the dopamine-NS relationship. Future studies of molecular mechanisms underlying the NS personality trait and related psychiatric disorders should consider the mediation effect of the neural structure. PMID:26003854

  7. Oxytocin and/or steroid hormone binding globulin infused into the ventral tegmental area modulates progestogen-mediated lordosis

    OpenAIRE

    Frye, Cheryl A.; Alicia A Walf

    2009-01-01

    Estradiol (E2) and progesterone (P4) have classical, steroid receptor-mediated actions in the ventral medial hypothalamus to initiate lordosis of female rodents. P4 and the P4 metabolite and neurosteroid, 5α-pregnan-3α-ol-20-one (3α,5α-THP), have non-classical actions in the midbrain ventral tegmental area (VTA) to modulate lordosis. We investigated the role of steroid hormone binding globulin (SHBG) and oxytocin in the VTA as mechanisms for these effects. Rats were ovariectomized and surgica...

  8. Dorsomedial hypothalamus mediates autonomic, neuroendocrine, and locomotor responses evoked from the medial preoptic area

    OpenAIRE

    Hunt, Joseph L.; Zaretsky, Dmitry V.; Sarkar, Sumit; DiMicco, Joseph A.

    2009-01-01

    Previous studies suggest that sympathetic responses evoked from the preoptic area in anesthetized rats require activation of neurons in the dorsomedial hypothalamus. Disinhibition of neurons in the dorsomedial hypothalamus in conscious rats produces physiological and behavioral changes resembling those evoked by microinjection of muscimol, a GABAA receptor agonist and neuronal inhibitor, into the medial preoptic area. We tested the hypothesis that all of these effects evoked from the medial p...

  9. Multi-Hazard Analysis for the Estimation of Ground Motion Induced by Landslides and Tectonics

    Science.gov (United States)

    Iglesias, Rubén; Koudogbo, Fifame; Ardizzone, Francesca; Mondini, Alessandro; Bignami, Christian

    2016-04-01

    Space-borne synthetic aperture radar (SAR) sensors allow obtaining all-day all-weather terrain complex reflectivity images which can be processed by means of Persistent Scatterer Interferometry (PSI) for the monitoring of displacement episodes with extremely high accuracy. In the work presented, different PSI strategies to measure ground surface displacements for multi-scale multi-hazard mapping are proposed in the context of landslides and tectonic applications. This work is developed in the framework of ESA General Studies Programme (GSP). The present project, called Multi Scale and Multi Hazard Mapping Space based Solutions (MEMpHIS), investigates new Earth Observation (EO) methods and new Information and Communications Technology (ICT) solutions to improve the understanding and management of disasters, with special focus on Disaster Risk Reduction rather than Rapid Mapping. In this paper, the results of the investigation on the key processing steps for measuring large-scale ground surface displacements (like the ones originated by plate tectonics or active faults) as well as local displacements at high resolution (like the ones related with active slopes) will be presented. The core of the proposed approaches is based on the Stable Point Network (SPN) algorithm, which is the advanced PSI processing chain developed by ALTAMIRA INFORMATION. Regarding tectonic applications, the accurate displacement estimation over large-scale areas characterized by low magnitude motion gradients (3-5 mm/year), such as the ones induced by inter-seismic or Earth tidal effects, still remains an open issue. In this context, a low-resolution approach based in the integration of differential phase increments of velocity and topographic error (obtained through the fitting of a linear model adjustment function to data) will be evaluated. Data from the default mode of Sentinel-1, the Interferometric Wide Swath Mode, will be considered for this application. Regarding landslides

  10. Surface motion induced by nuclear explosions beneath Pahute Mesa. Part I. Halfbreak, Greeley, Scotch, Boxcar events

    International Nuclear Information System (INIS)

    Results of surface motion studies conducted by Sandia Laboratories during seven underground nuclear explosions detonated beneath Pahute Mesa, Areas 19 and 20 of the Nevada Test Site, between 1966 and 1973 are reported. The report is divided into two parts of which this, Part I, includes (1) descriptions of the Pahute Mesa geological environment and of the purposes and instrumentation used in these programs (Chapter 1), and (2) description of four events, the data derived from each, and analysis of these data. These Part I events are HALFBEAK (Chapter 2), GREELEY (Chapter 3), SCOTCH (Chapter 4), and BOXCAR (Chapter 5) for all of which a nominally radial array of gage stations yielded data as a function of distance primarily, although in a few cases data were derived from stations at widely separated azimuths from the explosion. Results of the analysis indicate that average propagation velocity through the geologic column between the explosions and mesa surface was about 8800 ft/sec and that for horizontal distances greater than shot depth, refraction occurred within rhyolite flows with characteristic velocity of about 12,300 ft/sec. There is evidence which suggests possible deeper refraction at a velocity between 18,000 and 21,000 ft/sec. Only the verticle motion peaks follow a pattern amenable to regression analysis because geometrical effects influence horizontal motion amplitudes differently as horizontal distances increase. Particle velocities vary roughly as the inverse square of slant or radial range with exponent values ranging from -3.9 to -1.3. Displacements follow a similar pattern with exponents ranging from about -6 to -2. Displacement profiles at various times during the motion and displacement hodographs in the vertical-radial plane aid in understanding several local phenomena implied by individual motion records

  11. Klebsiella pneumoniae: resistance to carbapenems carbapenemase-mediated in the area of Piacenza

    Directory of Open Access Journals (Sweden)

    Massimo Confalonieri

    2010-12-01

    Full Text Available The detection of Klebsiella pneumoniae isolates showing a reduced susceptibility or resistance to carbapenems represents an increasing problem. The aim of this study is to survey the presence of carbapenemases producing strains in our country. 22 isolates of K. pneumoniae isolates showing carbapenems MIC => 2 by Vitek 2 System, were collected in the period May-August 2010 and studied for carbapenemases production using phenotypic confirmatory tests. The modified Hodge test and the DD-sinergy test with boronic acid yelded positive results for 17/22 strains; all the isolates resulted negative to the E-test MBL (imipenem and imipenem/EDTA. The results of this study confirm the recent emergence of KPC-producing K. pneumoniae strains in the area of Piacenza.The phenotypic tests employed appear reliable and simple for the confirmation of carbapenemases-production in K. pneumonie.

  12. A proof for insignificant effect of Brownian motion-induced micro-convection on thermal conductivity of nanofluids by utilizing molecular dynamics simulations

    Science.gov (United States)

    Babaei, Hasan; Keblinski, Pawel; Khodadadi, J. M.

    2013-02-01

    It has been recently demonstrated through experiments that the observed high enhancements in thermal conductivity of nanofluids are due to aggregation of nanoparticles rather than the previously stated mechanism of the Brownian motion-induced micro-convection. In this paper, we use equilibrium molecular dynamics simulations to investigate the role of micro-convection on the thermal conductivity of well-dispersed nanofluids. We show that while the individual terms in the heat current autocorrelation function associated with nanoparticle diffusion achieve significant values, these terms essentially cancel each other if correctly defined average enthalpy expressions are subtracted. Otherwise, erroneous thermal conductivity enhancements will be predicted, which are attributed to Brownian motion-induced micro-convection. Consequently, micro-convection does not contribute noticeably to the thermal conductivity and the predicted thermal conductivity enhancements are consistent with the effective medium theory.

  13. Acute alcohol effects on attentional bias are mediated by subcortical areas associated with arousal and salience attribution.

    Science.gov (United States)

    Nikolaou, Kyriaki; Field, Matt; Critchley, Hugo; Duka, Theodora

    2013-06-01

    Acute alcohol ingestion increases attentional bias to alcohol-related stimuli; however, the underlying cognitive and brain mechanisms remain unknown. We combined functional magnetic resonance imaging (fMRI) with performance of a dual task that probed attentional distraction by alcohol-related stimuli during 'conflict' processing: the Concurrent Flanker/Alcohol-Attentional bias task (CFAAT). In this task, an Eriksen Flanker task is superimposed on task-unrelated background pictures with alcohol-associated or neutral content. Participants respond to the direction of a central 'target' arrow and ignore adjacent congruent (low cognitive load) or incongruent (high cognitive load) 'flanking' arrows. Using a between-subject design, 40 healthy moderate-to-heavy social drinkers received either no alcohol (placebo), 0.4 g/kg (low dose), or 0.8 g/kg (high dose) of alcohol, and underwent fMRI while performing the CFAAT. The low alcohol dose, relative to placebo, increased response latencies on trials with alcohol-associated backgrounds and, under low cognitive load, increased the activity evoked by these pictures within a medial hypothalamic region. Under high cognitive load, the low alcohol dose, relative to placebo, elicited greater activity within a more lateral hypothalamic region, and reduced activity within frontal motor areas. The high alcohol dose, relative to placebo, did not reliably affect response latencies or neural responses to background images, but reduced overall accuracy under high cognitive load. This effect correlated with changes in reactivity within medial and dorsal prefrontal cortices. These data suggest that alcohol at a low dose primes attentional bias to alcohol-associated stimuli, an effect mediated by activation of subcortical hypothalamic areas implicated in arousal and salience attribution. PMID:23361162

  14. Normalization of flow-mediated dilation to shear stress area under the curve eliminates the impact of variable hyperemic stimulus

    Directory of Open Access Journals (Sweden)

    Mickleborough Timothy D

    2008-09-01

    Full Text Available Abstract Background Normalization of brachial artery flow-mediated dilation (FMD to individual shear stress area under the curve (peak FMD:SSAUC ratio has recently been proposed as an approach to control for the large inter-subject variability in reactive hyperemia-induced shear stress; however, the adoption of this approach among researchers has been slow. The present study was designed to further examine the efficacy of FMD normalization to shear stress in reducing measurement variability. Methods Five different magnitudes of reactive hyperemia-induced shear stress were applied to 20 healthy, physically active young adults (25.3 ± 0. 6 yrs; 10 men, 10 women by manipulating forearm cuff occlusion duration: 1, 2, 3, 4, and 5 min, in a randomized order. A venous blood draw was performed for determination of baseline whole blood viscosity and hematocrit. The magnitude of occlusion-induced forearm ischemia was quantified by dual-wavelength near-infrared spectrometry (NIRS. Brachial artery diameters and velocities were obtained via high-resolution ultrasound. The SSAUC was individually calculated for the duration of time-to-peak dilation. Results One-way repeated measures ANOVA demonstrated distinct magnitudes of occlusion-induced ischemia (volume and peak, hyperemic shear stress, and peak FMD responses (all p AUC (p = 0.785. Conclusion Our data confirm that normalization of FMD to SSAUC eliminates the influences of variable shear stress and solidifies the utility of FMD:SSAUC ratio as an index of endothelial function.

  15. Site-Specific Enhancement of γ-Aminobutyric Acid-Mediated Inhibition of Neural Activity by Ethanol in the Rat Medial Septal Area1

    OpenAIRE

    GIVENS, BENNET S.; Breese, George R.

    1990-01-01

    Because of uncertainty concerning the interaction of ethanol with γ-aminobutyric acid (GABA) receptor-mediated events, the present work was designed to investigate the effect of ethanol on GABA transmission in the rat septal area using behavioral and electrophysiological techniques. Microinjection of the GABAA agonist muscimol into the medial septal area (MSA) enhanced, and bicuculline administration antagonized, ethanol-induced impairment of the aerial righting reflex. Microinjection of thes...

  16. The effect of high speed vessel operations on ship's crew and embarked personnel aboard HSV-2 SWIFT in the areas of motion sickness and motion induced task interruptions

    OpenAIRE

    Diaz, Alvaro

    2005-01-01

    The Navy's use of high speed vessels such as HSV-2 SWIFT has raised questions of the effects of high speed motion on the ability of personnel to perform assigned duties. Performance degradation may occur during periods of excessive ship motion because of extreme motion sickness or periods of frequent task interruptions. With the use of high speed vessels expected to increase in the near future with the Littoral Combat Ship program, the issue of high speed motion effects on personnel becom...

  17. Site-specific enhancement of gamma-aminobutyric acid-mediated inhibition of neural activity by ethanol in the rat medial septal area.

    Science.gov (United States)

    Givens, B S; Breese, G R

    1990-08-01

    Because of uncertainty concerning the interaction of ethanol with gamma-aminobutyric acid (GABA) receptor-mediated events, the present work was designed to investigate the effect of ethanol on GABA transmission in the rat septal area using behavioral and electrophysiological techniques. Microinjection of the GABAA agonist muscimol into the medial septal area (MSA) enhanced, and bicuculline administration antagonized, ethanol-induced impairment of the aerial righting reflex. Microinjection of these drugs into the lateral septum (LSi) did not influence this measure of ethanol-induced sedation. Furthermore, intraseptal injections of muscimol or bicuculline in saline-treated rats had no effect on the aerial righting reflex. These data suggest that the MSA plays a critical modulatory role in the sedative actions of ethanol. To assess the effect of ethanol on muscimol responses in the MSA and LSi at the cellular level, GABA was applied by iontophoresis to rhythmically bursting neurons of the MSA and to cells in the LSi. The magnitude of the resultant inhibition by GABA on these cells was assessed before and after systemic administration of ethanol. Ethanol enhanced GABA-mediated inhibition of MSA neural activity, but did not alter GABA-mediated inhibition of cellular activity in the LSi. In contrast, the inhibition of cellular activity in the MSA, caused by a maximally effective concentration of the benzodiazepine flurazepam, was not altered by ethanol. Other work in the MSA demonstrated that electrical stimulation of the fimbria caused an inhibition of ongoing single unit activity that was reduced by concurrent application of bicuculline. The duration of this electrically elicited inhibition in the MSA was enhanced after ethanol injection and then recovered to base-line levels. In addition, ethanol (1.5 mg/kg) caused an enhancement of the inhibition induced by nipecotic acid, a GABA uptake inhibitor. These findings demonstrate that GABA-mediated neural inhibition is

  18. Organochlorine pesticides (OCPs) in the Indus River catchment area, Pakistan: Status, soil-air exchange and black carbon mediated distribution.

    Science.gov (United States)

    Bajwa, Anam; Ali, Usman; Mahmood, Adeel; Chaudhry, Muhammad Jamshed Iqbal; Syed, Jabir Hussain; Li, Jun; Zhang, Gan; Jones, Kevin C; Malik, Riffat Naseem

    2016-06-01

    Organochlorine pesticides (OCPs) were investigated in passive air and soil samples from the catchment area of the Indus River, Pakistan. ∑15OCPs ranged between 0.68 and 13.47 ng g(-1) in soil and 375.1-1975 pg m-(3) in air. HCHs and DDTs were more prevalent in soil and air compartments. Composition profile indicated that β-HCH and p,p'-DDE were the dominant of all metabolites among HCHs and DDTs respectively. Moreover, fBC and fTOC were assessed and evaluated their potential role in the distribution status of OCPs. The fTOC and fBC ranged between 0.77 and 2.43 and 0.04-0.30% respectively in soil. Regression analysis showed the strong influence of fBC than fTOC on the distribution of OCPs in the Indus River catchment area soil. Equilibrium status was observed for β-HCH, δ-HCH, p,p'-DDD, o,p'-DDT, TC, HCB and Heptachlor with ff ranged between 0.3 and 0.59 while assessing the soil-air exchange of OCPs. PMID:26978705

  19. Overcrowding-mediated stress alters cell proliferation in key neuroendocrine areas during larval development in Rhinella arenarum.

    Science.gov (United States)

    Distler, Mijal J; Jungblut, Lucas D; Ceballos, Nora R; Paz, Dante A; Pozzi, Andrea G

    2016-02-01

    Exposure to adverse environmental conditions can elicit a stress response, which results in an increase in endogenous corticosterone levels. In early life stages, it has been thoroughly demonstrated that amphibian larval growth and development is altered as a consequence of chronic stress by interfering with the metamorphic process, however, the underlying mechanisms involved have only been partially disentangled. We examined the effect of intraspecific competition on corticosterone levels during larval development of the toad Rhinella arenarum and its ultimate effects on cell proliferation in particular brain areas as well as the pituitary gland. While overcrowding altered the number of proliferating cells in the pituitary gland, hypothalamus, and third ventricle of the brain, no differences were observed in areas which are less associated with neuroendocrine processes, such as the first ventricle of the brain. Apoptosis was increased in hypothalamic regions but not in the pituitary. With regards to pituitary cell populations, thyrotrophs but not somatoatrophs and corticotrophs showed a decrease in the cell number in overcrowded larvae. Our study shows that alterations in growth and development, produced by stress, results from an imbalance in the neuroendocrine systems implicated in orchestrating the timing of metamorphosis. J. Exp. Zool. 9999A:XX-XX, 2016. © 2016 Wiley Periodicals, Inc. PMID:26817921

  20. Subtle reproductive impairment through nitric oxide-mediated mechanisms in sea urchins from an area affected by harmful algal blooms

    Science.gov (United States)

    Migliaccio, Oriana; Castellano, Immacolata; di Cioccio, Davide; Tedeschi, Gabriella; Negri, Armando; Cirino, Paola; Romano, Giovanna; Zingone, Adriana; Palumbo, Anna

    2016-05-01

    The health of the sea urchin Paracentrotus lividus, a key species in the Mediterranean Sea, is menaced by several pressures in coastal environments. Here, we aimed at assessing the reproductive ability of apparently healthy P. lividus population in a marine protected area affected by toxic blooms of Ostreospsis cf. ovata. Wide-ranging analyses were performed in animals collected prior to and during the bloom, as well as at several times thereafter, during the reproductive season. Adults showed a low fertilization rate, along with high nitric oxide (NO) levels in the gonads and the nitration of the major yolk protein toposome, which is an important player in sea urchin development. Serious developmental anomalies were observed in the progeny, which persist several months after the bloom. NO levels were high in the different developmental stages, which also showed variations in the transcription of several genes that were found to be directly or indirectly modulated by NO. These results highlight subtle but important reproductive flaws transmitted from the female gonads to the offspring with the NO involvement. Despite a recovery along time after the bloom, insidious damages can be envisaged in the local sea urchin population, with possible reverberation on the whole benthic system.

  1. An increase in the cerebral infarction area during fatigue is mediated by il-6 through an induction of fibrinogen synthesis

    Directory of Open Access Journals (Sweden)

    Hong Lei

    2014-06-01

    Full Text Available OBJECTIVES:Our study aimed to investigate the impact of fatigue on the severity of stroke and to explore the underlying mechanisms.METHODS:Fatigued male rats underwent middle cerebral artery occlusion and the infarcted brain area was determined. Then, coagulation parameters were assessed in the fatigued group and a control group. In addition, the level of fibrinogen was determined in rats deprived of sleep for various numbers of days. To study whether interleukin-6 was involved in fibrinogen synthesis during fatigue, we also measured levels of interleukin-6 in rats deprived of sleep for various numbers of days. Furthermore, brain injury by middle cerebral artery occlusion was measured in wild-type mice, interleukin-6-/- mice and wild-type mice treated with bezafibrate.RESULTS:More severe cerebral infarction was observed in the fatigued rats, resulting in an infarct ratio of 23.4%. The infarct ratio was significantly increased in the fatigued rats compared with that in the control group (8%, p<0.05. The level of fibrinogen was increased significantly in the fatigued rats compared with that in the control group. In addition, a marked reduction in fibrinogen level was observed in the fatigued interleukin-6-/- mice compared to their wild-type counterparts, whereas no difference was observed between fatigued wild-type mice and interleukin-6-/- rats treated with recombinant human interleukin-6. The reduction in brain injury due to middle cerebral artery occlusion during fatigue was observed in interleukin-6-/- mice and wild-type mice treated with bezafibrate.CONCLUSION:Fatigue could increase stroke severity and was associated with the interleukin-6-induced expression of fibrinogen.

  2. Increased desensitization of dopamine D₂ receptor-mediated response in the ventral tegmental area in the absence of adenosine A(2A) receptors.

    Science.gov (United States)

    Al-Hasani, R; Foster, J D; Metaxas, A; Ledent, C; Hourani, S M O; Kitchen, I; Chen, Y

    2011-09-01

    G-protein coupled receptors interact to provide additional regulatory mechanisms for neurotransmitter signaling. Adenosine A(2A) receptors are expressed at a high density in striatal neurons, where they closely interact with dopamine D₂ receptors and modulate effects of dopamine and responses to psychostimulants. A(2A) receptors are expressed at much lower densities in other forebrain neurons but play a more prominent yet opposing role to striatal receptors in response to psychostimulants in mice. It is, therefore, possible that A(2A) receptors expressed at low levels elsewhere in the brain may also regulate neurotransmitter systems and modulate neuronal functions. Dopamine D₂ receptors play an important role in autoinhibition of neuronal firing in dopamine neurons of the ventral tegmental area (VTA) and dopamine release in other brain areas. Here, we examined the effect of A(2A) receptor deletion on D₂ receptor-mediated inhibition of neuronal firing in dopamine neurons in the VTA. Spontaneous activity of dopamine neurons was recorded in midbrain slices, and concentration-dependent effects of the dopamine D₂ receptor agonist, quinpirole, was compared between wild-type and A(2A) knockout mice. The potency of quinpirole applied in single concentrations and the expression of D₂ receptors were not altered in the VTA of the knockout mice. However, quinpirole applied in stepwise escalating concentrations caused significantly reduced maximal inhibition in A(2A) knockout mice, indicating an enhanced agonist-induced desensitization of D₂ receptors in the absence of A(2A) receptors. The A(2A) receptor agonist, CGS21680, did not exert any effect on dopamine neuron firing or response to quinpirole, revealing a novel non-pharmacological interaction between adenosine A(2A) receptors and dopaminergic neurotransmission in midbrain dopamine neurons. Altered D₂ receptor desensitization may result in changes in dopamine neuron firing rate and pattern and dopamine

  3. AhR-mediated potency of sediments and soils in estuarine and coastal areas of the Yellow Sea region: A comparison between Korea and China

    International Nuclear Information System (INIS)

    Extracts of sediments (n = 45) and soils (n = 37) collected from the coast of the Yellow Sea, in Korea and China, were screened for their ability to induce dioxin-like gene expression in vitro using the H4IIE-luc, transactivation bioassay. Significant dioxin-like potency was observed except for a few soils from Korea. Concentrations of TCDD-EQ (2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents) in sediments were comparable between Korea and China, but concentrations of TCDD-EQ in soil were 2-fold greater from Korea. Mass balance analysis indicated that concentrations of TCDD-EQ were to some degree chemical- and/or matrix-dependent, but were much more site-specific. For example, the proportion of the TCDD-EQ that could be identified varied among locations, which suggests different sources. Unidentified AhR-active compounds represented a greater proportion of the TCDD-EQ in samples from Korea, which suggests that sources in Korea were more complex than those in China. Potential sources of TCDD-EQ were investigated by considering land-uses and local activities. - Highlights: ► AhR potencies of 45 sediment and 37 soil samples of the Yellow Sea region were determined. ► Some samples contained dioxin-like compounds from regional human activities. ► PAHs were dominant and widespread contributors in both sediments and soils. ► Unknown AhR agonists were widely distributed in sediments and soils. ► Dominant AhR agonists in sediments and soils were found to be site-specific. - AhR-mediated potencies of sediments and soils in estuarine and coastal areas of the West Sea of Korea and north Bohai Sea of China was due known and unknown AhR agonists.

  4. Investigating the spatial variability in incidence of coronary heart disease in the Gazel cohort: the impact of area socioeconomic position and mediating role of risk factors.

    OpenAIRE

    Silhol, Romain; Zins, Marie; Chauvin, Pierre; Chaix, Basile

    2011-01-01

    STUDY OBJECTIVE: The aim of the study was to improve understanding of the relationships between contextual socioeconomic characteristics and coronary heart disease (CHD) incidence in France. Several authors have suggested that CHD risk factors (diabetes, hypertension, cholesterol, overweight, tobacco consumption) may partly mediate associations between socioeconomic environmental variables and CHD. Studies have assessed the overall mediating role of CHD risk factors, but have never investigat...

  5. Mediation Analysis

    OpenAIRE

    David P. MacKinnon; Fairchild, Amanda J.; Fritz, Matthew S.

    2007-01-01

    Mediating variables are prominent in psychological theory and research. A mediating variable transmits the effect of an independent variable on a dependent variable. Differences between mediating variables and confounders, moderators, and covariates are outlined. Statistical methods to assess mediation and modern comprehensive approaches are described. Future directions for mediation analysis are discussed.

  6. Mediation in Romanian Legislation

    Directory of Open Access Journals (Sweden)

    Gianina Anemona Radu

    2012-05-01

    Full Text Available The complexity of the current social relations generates the necessity of developing and applyingnew methods of settling conflicts. Mediation can serve as an effective tool in resolving various conflictsincluding the criminal matters. This article gives a panoramic view on the application of the concept ofmediation and highlights the main features of mediation in criminal cases as they are reported to the nationallegislation and the legislation of Romania. Therefore the advantages of mediation and the opportunity toapply the latter in order to slave the conflicts caused by the commission of criminal offences are still beingdiscussed. The Romanian legislation and the Community rules establish the scope of expressly exemptedareas, the sides of freedom being the main principle, the mandatory dispositions being the exception. Fromthe contents of the Law 192/2006 result that mediation is exercisable in all areas with the condition that therights which make the subject of mediation could be used by the sides of the mediation. The mediation theoryanalyses the extrajudicial mediation and judicial mediation settlement.

  7. Mediation and Counseling Services: A Viable Partnership

    Science.gov (United States)

    Hodges, Shannon

    2009-01-01

    Mediation has become common in many areas of society, including marital dissolution, community disputes, governmental agencies, and business and industry. Though higher education has been slower than society to adopt mediation services, campus mediation is becoming increasingly more common. This article explains why mediation is a viable…

  8. Complex Mediation

    DEFF Research Database (Denmark)

    Bødker, Susanne; Andersen, Peter Bøgh

    2005-01-01

    This article has its starting point in a large number of empirical findings regarding computer-mediated work. These empirical findings have challenged our understanding of the role of mediation in such work; on the one hand as an aspect of communication and cooperation at work and on the other ha...

  9. Specialized Mediation.

    Science.gov (United States)

    Hammond, Carol; And Others

    1992-01-01

    Six articles discuss librarians as mediators in special circumstances. Highlights include the reference librarian and the information paraprofessional; effective reference mediation for nontraditional public library users, including mentally impaired patrons and illiterate adults; the academic librarian's role in the education process; and…

  10. Examining Rotational Ground Motion Induced by Tornados

    Science.gov (United States)

    Kessler, Elijah; Dunn, Robert

    2016-03-01

    Ring lasers are well known for their ability to detect rotation and to serve as replacements for mechanical gyroscopes. The sensitivity of large ring lasers to various forms of ground motion is less familiar. Since ring lasers preferentially measure rotational ground motion and a standard seismograph is designed to measure translational and vertical ground motion, each device responds to different aspects of ground movement. Therefore, the two instruments will be used to explore responses to microseisms, earthquake generated shear waves, and in particular tornado generated ground movement. On April 27, 2014 an EF4 tornado devastated Vilonia, AR a small town ~ 21 km from the Hendrix College ring laser. The proximity of the tornado's path to the ring laser interferometer and to a seismograph located in Vilonia provided the opportunity to examine the response of these instruments to tornadic generated ground motion. Our measurements suggest tornadic weather systems can produce both rotational and lateral ground motion. This contention is supported by an after the fact damage survey which found that the tornado flattened a forest in which trees were uprooted and laid down in a pair of converging arcs with the centerline pointed in the direction of the tornado's path.

  11. Mediatized Humanitarianism

    DEFF Research Database (Denmark)

    Vestergaard, Anne

    2014-01-01

    The article investigates the implications of mediatization for the legitimation strategies of humanitarian organizations. Based on a (full population) corpus of ~400 pages of brochure material from 1970 to 2007, the micro-textual processes involved in humanitarian organizations' efforts to...... legitimate themselves and their moral claim were examined. A time trend analysis of the prioritization of actors in the material indicates that marked shifts in legitimation loci have taken place during the past 40 years. A discourse analysis unfolds the three dominant discourses behind these shifts, namely...... legitimation by accountancy, legitimation by institutionalization, and legitimation by compensation. The analysis relates these changes to a problem of trust associated with mediatization through processes of mediation....

  12. Mediatized play

    DEFF Research Database (Denmark)

    Johansen, Stine Liv

    Children’s play must nowadays be understood as a mediatized field in society and culture. Media – understood in a very broad sense - holds severe explanatory power in describing and understanding the practice of play, since play happens both with, through and inspired by media of different sorts........ In this presentation the case of ‘playing soccer’ will be outlined through its different mediated manifestations, including soccer games and programs on TV, computer games, magazines, books, YouTube videos and soccer trading cards....

  13. Mediating Business

    DEFF Research Database (Denmark)

    "Mediating Business" is a study of the expansion of business journalism. Building on evidence from Denmark, Finland, Norway and Sweden, "Mediating Business" is a comparative and multidisciplinary study of one of the major transformations of the mass media and the realm of business - nationally and...... globally. The book explores the history of key innovations and innovators in the business press. It analyzes changes in the discourse of business journalism associated with the growth in business news and the development of new ways of framing business issues and events. Finally, it examines the...... organizational implications of the increased media visibility of business and, in particular, the development of corporate governance and media relations....

  14. The mediatization of ethical consumption

    DEFF Research Database (Denmark)

    Eskjær, Mikkel Fugl

    2013-01-01

    Over the years, mediatization studies have investigated the influence of media in numerous sections of contemporary society. One area that has received limited attention is the mediatization of consumption, particularly issues concerning ethical consumption. This article presents a study of how...... mediatization is transforming modern consumption and contributing to the mainstreaming of ethical consumption. Based on a study of a Danish online eco-store, the article argues that modern ethical consumption increasingly depends on new media practices to present sustainable consumption as practical and...

  15. The mediatization of ethical consumption

    Directory of Open Access Journals (Sweden)

    Mikkel Fugl Eskjær

    2013-03-01

    Full Text Available Over the years, mediatization studies have investigated the influence of media in numerous sections of contemporary society. One area that has received limited attention is the mediatization of consumption, particularly issues concerning ethical consumption. This article presents a study of how mediatization is transforming modern consumption and contributing to the mainstreaming of ethical consumption. Based on a study of a Danish online eco-store, the article argues that modern ethical consumption increasingly depends on new media practices to present sustainable consumption as practical and fashionable while effacing underlying processes of rationalisation and commercialisation.

  16. Mediation of information and educational mediation: conceptual discussions

    Directory of Open Access Journals (Sweden)

    Helena Célia de Souza Sacerdote

    2016-04-01

    Full Text Available Introduction: This is systematization of theoretical and methodological contributions related to the concepts of mediation information and pedagogical mediation in the literature. Objective: To understand possible intersection of information science and Online Education with regard to these concepts to check that both can be considered as analogous in its essence and practice. Methodology: Literature review based on literature by consulting the scientific productions selected in search of SciELO.ORG databases and EBSCO Host, the portal of CAPES / MEC and Google Scholar. Results: The most cited concepts in information science and education were de Almeida Junior (2009 and Masetto (2013, respectively. Conclusion: It is observed that the concept of mediation can move interchangeably between both areas. This is because the evidence found in the productions of the last five years indicate that the concept of information of mediation seems to have found its bases in education (educational psychology.

  17. PRACTICAL ASPECTS OF MEDIATION

    OpenAIRE

    IULIA FLOCA

    2011-01-01

    Today the Romanian state gives some advantages to those who use mediation. If the Romanian state would take further steps, mediation would work as in the countries with old tradition. The article refers to success and failure got in the two years of practice. The mediation can be seen in two aspects: The first aspect regarding the mediation itself can lead to a mediation agreement. The mediation agreement gives both winnings to the conflict parts and professional satisfactions to the mediator...

  18. Micro dynamics in mediation

    OpenAIRE

    Boserup, Hans

    2014-01-01

    The author has identified a number of styles in mediation, which lead to different processes and different outcomes. Through discourse and conversation analysis he examines the micro dynamics in three of these, the postmodern styles: systemic, transformative and narrative mediation. The differences between the three mediation ideologies and practice is illustrated through role play scripts enacted in each style. Mediator and providers of mediation and trainers in mediation are encouraged to a...

  19. Water-Mediated Hydrophobic Interactions.

    Science.gov (United States)

    Ben-Amotz, Dor

    2016-05-27

    Hydrophobic interactions are driven by the combined influence of the direct attraction between oily solutes and an additional water-mediated interaction whose magnitude (and sign) depends sensitively on both solute size and attraction. The resulting delicate balance can lead to a slightly repulsive water-mediated interaction that drives oily molecules apart rather than pushing them together and thus opposes their direct (van der Waals) attraction for each other. As a consequence, competing solute size-dependent crossovers weaken hydrophobic interactions sufficiently that they are only expected to significantly exceed random thermal energy fluctuations for processes that bury more than ∼1 nm(2) of water-exposed area. PMID:27215821

  20. General Gaugino Mediation

    OpenAIRE

    Sudano, Matthew

    2010-01-01

    The spectrum of a class of gaugino mediation models with arbitrary hidden sector is considered. These models are defined by a diagonal breaking of the mediating gauge group, which places them outside the realm of General Gauge Mediation. While gauginos get masses as in ordinary gauge mediation, the scalar masses are screened.

  1. Conceptualising International Peace Mediation - Bring Back the Law

    OpenAIRE

    Higgins, Noelle; Daly, Brenda

    2011-01-01

    Mediation has been acknowledged and utilised for a number of decades as an effective method of alternative dispute resolution in a variety of areas of law, including family law, commercial law and medical law. A uniform, standardised framework exists within legal discourse which clearly identifies and categorises three main styles of mediation as facilitative, evaluative and transformative mediation. In the post-Cold War period, mediation has also emerged as an important resolution tool in ar...

  2. Causal mediation analysis with a latent mediator.

    Science.gov (United States)

    Albert, Jeffrey M; Geng, Cuiyu; Nelson, Suchitra

    2016-05-01

    Health researchers are often interested in assessing the direct effect of a treatment or exposure on an outcome variable, as well as its indirect (or mediation) effect through an intermediate variable (or mediator). For an outcome following a nonlinear model, the mediation formula may be used to estimate causally interpretable mediation effects. This method, like others, assumes that the mediator is observed. However, as is common in structural equations modeling, we may wish to consider a latent (unobserved) mediator. We follow a potential outcomes framework and assume a generalized structural equations model (GSEM). We provide maximum-likelihood estimation of GSEM parameters using an approximate Monte Carlo EM algorithm, coupled with a mediation formula approach to estimate natural direct and indirect effects. The method relies on an untestable sequential ignorability assumption; we assess robustness to this assumption by adapting a recently proposed method for sensitivity analysis. Simulation studies show good properties of the proposed estimators in plausible scenarios. Our method is applied to a study of the effect of mother education on occurrence of adolescent dental caries, in which we examine possible mediation through latent oral health behavior. PMID:26363769

  3. Shared mediated workspaces

    OpenAIRE

    Greef, Tjerk de; Gullström, Charlie; Handberg, Leif; Nefs, H.T.; Parnes, Peter

    2012-01-01

    Shared mediated spaces provide viable alternatives for meetings and interactions. The development of collaborative mediated workspaces and shared negotiation spaces will have a fundamental impact on all human practices. Previous design-led research, has identified spatial design concepts, such as mediated gaze, and spatial montage, which, if unaddressed, may be said to impose friction, and thus impact negatively on the experience of mediated presence. The current paper discusses a set of conc...

  4. Mediation and Conflict Management

    OpenAIRE

    Gerald Eisenkopf

    2009-01-01

    Mediation is a popular process to manage conflicts, but there is little systematic insight into its mechanisms. This paper discusses the results from an experiment in which a mediator can induce two conflict parties to behave cooperatively. If the mediator recommends cooperative behavior and threatens to punish deviations, she achieves the efficient solution. Similar results even obtain if the mediator is biased towards one party or has no incentive to prevent the conflict. Communication betw...

  5. Confidentiality of mediation communications

    OpenAIRE

    Koo, AKC

    2011-01-01

    Discusses the common law protection afforded to mediation negotiations by the without prejudice rule, legal professional privilege and the mediation agreement signed by all parties prior to the commencement of the mediation process. Examines the inclusion of admissions within the without prejudice rule, and the exceptions to the rule. Notes two pieces of legislation offering protection, namely the US Uniform Mediation Act 2001 and Directive 2008/52. Argues that the limited protection in the U...

  6. Bayesian Mediation Analysis

    OpenAIRE

    Yuan, Ying; MacKinnon, David P.

    2009-01-01

    This article proposes Bayesian analysis of mediation effects. Compared to conventional frequentist mediation analysis, the Bayesian approach has several advantages. First, it allows researchers to incorporate prior information into the mediation analysis, thus potentially improving the efficiency of estimates. Second, under the Bayesian mediation analysis, inference is straightforward and exact, which makes it appealing for studies with small samples. Third, the Bayesian approach is conceptua...

  7. Mediation as Signal

    OpenAIRE

    Holler, M.J.; Lindner, I.

    2004-01-01

    This paper analyzes mediation as a signal. Starting from a stylized case, a game theoretical model of one-sided incomplete information, taken from Cho and Kreps (1987), is applied to discuss strategic effects of mediation. It turns out that to reject mediation can be interpreted as a ”negative signal” while the interpretation of accepting or proposing mediation is ambiguous and does not necessarily change the prior beliefs of the uninformed party. This asymmetry suggests that, in equilibrium,...

  8. Mediators as Walrasian Auctioneers

    OpenAIRE

    Dickenson, David L.

    2004-01-01

    This article opens up mediation to systematic economic analysis by considering mediators as analogous.to the Walrasian auctioneers of exchange theory. By altering trade-off rates among bargaining issues, mediators facilitate a process leading towards Pareto efficient voluntary settlements.

  9. Hybrid Gauge Mediation

    OpenAIRE

    McGarrie, Moritz

    2011-01-01

    Inspired by four dimensional (de)constructions, we use the framework of "General gauge mediation in five dimensions" to interpolate between gaugino and ordinary gauge mediation. In particular we emphasise that an intermediate hybrid regime of mediation may be obtained in these higher dimensional models as has been obtained in the quiver gauge models.

  10. Bayesian Mediation Analysis

    Science.gov (United States)

    Yuan, Ying; MacKinnon, David P.

    2009-01-01

    In this article, we propose Bayesian analysis of mediation effects. Compared with conventional frequentist mediation analysis, the Bayesian approach has several advantages. First, it allows researchers to incorporate prior information into the mediation analysis, thus potentially improving the efficiency of estimates. Second, under the Bayesian…

  11. mediation: R Package for Causal Mediation Analysis

    Directory of Open Access Journals (Sweden)

    Dustin Tingley

    2014-09-01

    Full Text Available In this paper, we describe the R package mediation for conducting causal mediation analysis in applied empirical research. In many scientific disciplines, the goal of researchers is not only estimating causal effects of a treatment but also understanding the process in which the treatment causally affects the outcome. Causal mediation analysis is frequently used to assess potential causal mechanisms. The mediation package implements a comprehensive suite of statistical tools for conducting such an analysis. The package is organized into two distinct approaches. Using the model-based approach, researchers can estimate causal mediation effects and conduct sensitivity analysis under the standard research design. Furthermore, the design-based approach provides several analysis tools that are applicable under different experimental designs. This approach requires weaker assumptions than the model-based approach. We also implement a statistical method for dealing with multiple (causally dependent mediators, which are often encountered in practice. Finally, the package also offers a methodology for assessing causal mediation in the presence of treatment noncompliance, a common problem in randomized trials.

  12. Phenomenological Implications of Deflected Mirage Mediation: Comparison with Mirage Mediation

    OpenAIRE

    Altunkaynak, Baris; Everett, Lisa L.; Kim, Ian-Woo; Nelson, Brent D.; Rao, Yongyan

    2010-01-01

    We compare the collider phenomenology of mirage mediation and deflected mirage mediation, which are two recently proposed "mixed" supersymmetry breaking scenarios motivated from string compactifications. The scenarios differ in that deflected mirage mediation includes contributions from gauge mediation in addition to the contributions from gravity mediation and anomaly mediation also present in mirage mediation. The threshold effects from gauge mediation can drastically alter the low energy s...

  13. Technology-Use Mediation

    DEFF Research Database (Denmark)

    Bansler, Jørgen P.; Havn, Erling C.

    This study analyzes how a group of ‘mediators’ in a large, multinational company adapted a computer-mediated communication technology (a ‘virtual workspace’) to the organizational context (and vice versa) by modifying features of the technology, providing ongoing support for users, and promoting...... appropriate conventions of use. Our findings corroborate earlier research on technology-use mediation, which suggests that such mediators can exert considerable influence on how a particular technology will be established and used in an organization. However, this study also indicates that the process of...... technology-use mediation is more complex and indeterminate than earlier literature suggests. In particular, we want to draw attention to the fact that advanced computer-mediated communication technologies are equivocal and that technology-use mediation consequently requires ongoing sensemaking (Weick 1995)....

  14. The Schizosaccharomyces pombe Mediator

    DEFF Research Database (Denmark)

    Venturi, Michela

    In the past several years great attention has been dedicated to the characterization of the Mediator complex in a different range of model organisms. Mediator is a conserved co-activator complex involved in transcriptional regulation and it conveys signals from regulatory transcription factors to...... the basal transcription machinery. Mediator was initially isolated from Saccharomyces cerevisiae based on its ability to render a RNA polymerase II in vitro transcription system responsive to activators. Additionally, structural studies have revealed striking structural similarities between S....... cerevisiae, Schizosaccharomyces pombe and mammalian Mediator. In our study, we have taken the S. pombe Mediator into consideration and characterized genetically and biochemically two subunits already know in S. cerevisiae, Med9 and Med11, but still not identified in the S. pombe Mediator. Genetic analysis...

  15. Technology-Use Mediation

    DEFF Research Database (Denmark)

    Bansler, Jørgen P.; Havn, Erling C.

    2003-01-01

    This study analyzes how a group of ‘mediators’ in a large, multinational company adapted a computer-mediated communication technology (a ‘virtual workspace’) to the organizational context (and vice versa) by modifying features of the technology, providing ongoing support for users, and promoting...... technology-use mediation is more complex and indeterminate than earlier literature suggests. In particular, we want to draw attention to the fact that advanced computer-mediated communication technologies are equivocal and that technology-use mediation consequently requires ongoing sensemaking (Weick 1995)....... appropriate conventions of use. Our findings corroborate earlier research on technology-use mediation, which suggests that such mediators can exert considerable influence on how a particular technology will be established and used in an organization. However, this study also indicates that the process of...

  16. Prospects for Mirage Mediation

    OpenAIRE

    Pierce, Aaron; Thaler, Jesse

    2006-01-01

    Mirage mediation reduces the fine-tuning in the minimal supersymmetric standard model by dynamically arranging a cancellation between anomaly-mediated and modulus-mediated supersymmetry breaking. We explore the conditions under which a mirage "messenger scale" is generated near the weak scale and the little hierarchy problem is solved. We do this by explicitly including the dynamics of the SUSY-breaking sector needed to cancel the cosmological constant. The most plausible scenario for generat...

  17. Immunologically mediated oral diseases

    OpenAIRE

    Sudha Jimson; Balachader, N.; N Anita; Babu, R

    2015-01-01

    Immune mediated diseases of oral cavity are uncommon. The lesions may be self-limiting and undergo remission spontaneously. Among the immune mediated oral lesions the most important are lichen planus, pemphigus, erythema multiformi, epidermolysis bullosa, systemic lupus erythematosis. Cellular and humoral mediated immunity play a major role directed against epithelial and connective tissue in chronic and recurrent patterns. Confirmatory diagnosis can be made by biopsy, direct and indirect imm...

  18. Does area V3A predict positions of moving objects?

    Directory of Open Access Journals (Sweden)

    Gerrit W Maus

    2010-11-01

    Full Text Available A gradually fading moving object is perceived to disappear at positions beyond its luminance detection threshold, whereas abrupt offsets are usually localised accurately. What role does retinotopic activity in visual cortex play in this motion-induced mislocalization of the endpoint of fading objects? Using functional magnetic resonance imaging (fMRI, we localised regions of interest (ROIs in retinotopic maps abutting the trajectory endpoint of a bar moving either towards or away from this position while gradually decreasing or increasing in luminance. Area V3A showed predictive activity, with stronger fMRI responses for motion towards versus away from the ROI. This effect was independent of the change in luminance. In Area V1 we found higher activity for high-contrast onsets and offsets near the ROI, but no significant differences between motion directions. We suggest that perceived final positions of moving objects are based on an interplay of predictive position representations in higher motion-sensitive retinotopic areas and offset transients in primary visual cortex.

  19. Teaching Mediated Public Relations.

    Science.gov (United States)

    Kent, Michael L.

    2001-01-01

    Discusses approaches to teaching a mediated public relations course, emphasizing the World Wide Web. Outlines five course objectives, assignments and activities, evaluation, texts, and lecture topics. Argues that students mastering these course objectives will understand ethical issues relating to media use, using mediated technology in public…

  20. Mediation and Domestic Violence

    Directory of Open Access Journals (Sweden)

    Jacques Faget

    2005-07-01

    Full Text Available This paper analyzes the potential and limits of recourse to mediation for regulating domestic violence. On the basis of an empirical study of its implementation in France and of the existing academic literature, it shows the existence of two types of practices reflecting two conceptions of mediation and more generally, two conceptions of the articulation between social and penal regulation

  1. Mediation and Domestic Violence

    OpenAIRE

    Jacques Faget

    2005-01-01

    This paper analyzes the potential and limits of recourse to mediation for regulating domestic violence. On the basis of an empirical study of its implementation in France and of the existing academic literature, it shows the existence of two types of practices reflecting two conceptions of mediation and more generally, two conceptions of the articulation between social and penal regulation

  2. Music, Radio, and Mediatization

    DEFF Research Database (Denmark)

    Krogh, Mads; Michelsen, Morten

    2016-01-01

    Mediatization has become a key concept for understanding the relations between media and other cultural and social fields. Contributing to the discussions related to the concept of mediatization, this article discusses how practices of radio and music(al life) influence each other. We follow Deacon......’s and Stanyer’s advice to supplement the concept of mediatization with ‘a series of additional concepts at lower levels of abstraction’ and suggest, in this respect, the notion of heterogeneous milieus of music– radio. Hereby, we turn away from the all-encompassing perspectives related to the concept of...... mediatization where media as such seem to be ascribed agency. Instead, we consider historical accounts of music–radio in order to address the complex non- linearity of concrete processes of mediatization as they take place in the multiple meetings between a decentred notion of radio and musical life....

  3. Revitalization Areas

    Data.gov (United States)

    Department of Housing and Urban Development — Revitalization areas are HUD-designated neighborhoods in need of economic and community development and where there is already a strong commitment by the local...

  4. Axionic Mirage Mediation

    International Nuclear Information System (INIS)

    In this talk, we propose a model of mirage mediation, in which Peccei-Quinn symmetry is incorporated. In this axionic mirage mediation, it is shown that the Peccei-Quinn symmetry breaking scale is dynamically determined around 1010 GeV to 1012 GeV due to the supersymmetry breaking effects. The problems in the original mirage mediation such as the μ-problem and the moduli problem can be solved simultaneouly. Furthermore, in our model the axino, which is the superpartner of the axion, is the lightest sparticle.

  5. Axionic Mirage Mediation

    CERN Document Server

    Nakamura, Shuntaro; Yamaguchi, Masahiro

    2008-01-01

    In this talk, we propose a model of mirage mediation, in which Peccei-Quinn symmetry is incorporated. In this \\textit{axionic mirage mediation}, it is shown that the Peccei-Quinn symmetry breaking scale is dynamically determined around $10^{10}$ GeV to $10^{12}$ GeV due to the supersymmetry breaking effects. The problems in the original mirage mediation such as the $\\mu$-problem and the moduli problem can be solved simultaneouly. Furthermore, in our model the axino, which is the superpartner of the axion, is the lightest sparticle.

  6. Prospects for mirage mediation

    International Nuclear Information System (INIS)

    Mirage mediation reduces the fine-tuning in the minimal supersymmetric standard model by dynamically arranging a cancellation between anomaly-mediated and modulus-mediated supersymmetry breaking. We explore the conditions under which a mirage 'messenger scale' is generated near the weak scale and the little hierarchy problem is solved. We do this by explicitly including the dynamics of the SUSY-breaking sector needed to cancel the cosmological constant. The most plausible scenario for generating a low mirage scale does not readily admit an extra-dimensional interpretation. We also review the possibilities for solving the μ/Bμ problem in such theories, a potential hidden source of fine-tuning

  7. Axionic Mirage Mediation

    OpenAIRE

    Nakamura, Shuntaro; Okumura, Ken-ichi; Yamaguchi, Masahiro

    2008-01-01

    In this talk, we propose a model of mirage mediation, in which Peccei-Quinn symmetry is incorporated. In this \\textit{axionic mirage mediation}, it is shown that the Peccei-Quinn symmetry breaking scale is dynamically determined around $10^{10}$ GeV to $10^{12}$ GeV due to the supersymmetry breaking effects. The problems in the original mirage mediation such as the $\\mu$-problem and the moduli problem can be solved simultaneouly. Furthermore, in our model the axino, which is the superpartner ...

  8. General resonance mediation

    Energy Technology Data Exchange (ETDEWEB)

    McGarrie, Moritz

    2012-07-15

    We extend the framework of general gauge mediation to cases where the mediating fields have a nontrivial spectral function, as might arise from strong dynamics. We demonstrate through examples that this setup describes a broad class of possible models of gauge mediated supersymmetry breaking. A main emphasis is to give general formulas for cross sections for {sigma}(visible {yields} hidden) in these resonance models. We will also give formulas for soft masses, A-terms and demonstrate the framework with a holographic setup.

  9. Gravity in gauge mediation

    International Nuclear Information System (INIS)

    We investigate O'Raifeartaigh-type models for F-term supersymmetry breaking in gauge mediation scenarios in the presence of gravity. It is pointed out that the vacuum structure of those models is such that in metastable vacua gravity mediation contribution to scalar masses is always suppressed to the level below 1 percent, almost sufficient for avoiding FCNC problem. Close to that limit, gravitino mass can be in the range 10-100 GeV, opening several interesting possibilities for gauge mediation models, including Giudice-Masiero mechanism for μ and Bμ generation. Gravity sector can include stabilized moduli.

  10. Phenomenological Implications of Deflected Mirage Mediation: Comparison with Mirage Mediation

    CERN Document Server

    Altunkaynak, Baris; Kim, Ian-Woo; Nelson, Brent D; Rao, Yongyan

    2010-01-01

    We compare the collider phenomenology of mirage mediation and deflected mirage mediation, which are two recently proposed "mixed" supersymmetry breaking scenarios motivated from string compactifications. The scenarios differ in that deflected mirage mediation includes contributions from gauge mediation in addition to the contributions from gravity mediation and anomaly mediation also present in mirage mediation. The threshold effects from gauge mediation can drastically alter the low energy spectrum from that of pure mirage mediation models, resulting in some cases in a squeezed gaugino spectrum and a gluino that is much lighter than other colored superpartners. We provide several benchmark deflected mirage mediation models and construct model lines as a function of the gauge mediation contributions, and discuss their discovery potential at the LHC.

  11. Mediator scolar - School Mediator (Romanian version)

    OpenAIRE

    Madalina CONSTANTIN

    2011-01-01

    The present article proposes to highlight the most important concepts with regard to school mediator. In this case we intend to add into discution the folowing: 1. Planning activities 2 Teamwork 3. Professional Development 4. PC Use 5. Communication 6. Solving conflicts 7. Developing school-community partnership 8. Counseling families / social groups disadvantaged on the role and importance of schooling 9. Implementation of inclusive practices 10. Overcoming emotional and behavioral difficult...

  12. Technology-Use Mediation

    DEFF Research Database (Denmark)

    Bansler, Jørgen P.; Havn, Erling C.

    2004-01-01

    deepens our understanding of how organizations appropriate new electronic communication media. The paper analyzes how a group of mediators in a large, multinational company adapted a new web-based CMC technology (a virtual workspace) to the local organizational context (and vice versa) by modifying...... features of the technology, providing ongoing support for users, and promoting appropriate conventions of use. We found that these mediators exerted considerable influence on how the technology was established and used in the organization. The mediators were not neutral facilitators of a well......Implementation of new computer-mediated communication (CMC) systems in organizations is a complex socio-technical endeavour, involving the mutual adaptation of technology and organization over time. Drawing on the analytic concept of sensemaking, this paper provides a theoretical perspective that...

  13. Technology-Use Mediation

    DEFF Research Database (Denmark)

    Bansler, Jørgen P.; Havn, Erling C.

    2004-01-01

    Implementation of new computer-mediated communication (CMC) systems in organizations is a complex socio-technical endeavour, involving the mutual adaptation of technology and organization over time. Drawing on the analytic concept of sensemaking, this paper provides a theoretical perspective that...... deepens our understanding of how organizations appropriate new electronic communication media. The paper analyzes how a group of mediators in a large, multinational company adapted a new web-based CMC technology (a virtual workspace) to the local organizational context (and vice versa) by modifying...... features of the technology, providing ongoing support for users, and promoting appropriate conventions of use. We found that these mediators exerted considerable influence on how the technology was established and used in the organization. The mediators were not neutral facilitators of a well...

  14. Stellar motion induced by gravitational instabilities in protoplanetary discs

    Science.gov (United States)

    Michael, Scott; Durisen, R. H.

    2010-07-01

    We test the effect of assumptions about stellar motion on the behaviour of gravitational instabilities (GIs) in protoplanetary discs around solar-type stars by performing two simulations that are identical in all respects except the treatment of the star. In one simulation, the star is assumed to remain fixed at the centre of the inertial reference frame. In the other, stellar motion is handled properly by including an indirect potential in the hydrodynamic equations to model the star's reference frame as one which is accelerated by star/disc interactions. The discs in both simulations orbit a solar mass star, initially extend from 2.3 to 40 au with a ϖ-1/2 surface density profile, and have a total mass of 0.14 Msolar. The γ = 5/3 ideal gas is assumed to cool everywhere with a constant cooling time of two outer rotation periods. The overall behaviour of the disc evolution is similar, except for weakening in various measures of GI activity by about at most tens of per cent for the indirect potential case. Overall conclusions about disc evolution in earlier papers by our group, where the star was always assumed to be fixed in an inertial frame, remain valid. There is no evidence for independent one-armed instabilities, like the Stimulation by the Long-range Interaction of Newtonian Gravity (SLING), in either simulation. On the other hand, the stellar motion about the system centre of mass (COM) in the simulation with the indirect potential is substantial, up to 0.25 au during the burst phase, as GIs initiate, and averaging about 0.9 au during the asymptotic phase, when the GIs reach an overall balance of heating and cooling. These motions appear to be a stellar response to non-linear interactions between discrete global spiral modes in both the burst and asymptotic phases of the evolution, and the star's orbital motion about the COM reflects the orbit periods of disc material near the corotation radii of the dominant spiral waves. This motion is, in principle, large enough to be observable and could be confused with stellar wobble due to the presence of one or more super-Jupiter mass protoplanets orbiting at 10's au. We discuss why the excursions in our simulation are so much larger than those seen in simulations by Rice et al.

  15. Stellar Motion Induced by Gravitational Instabilities in Protoplanetary Disks

    CERN Document Server

    Michael, Scott

    2010-01-01

    We test the effect of assumptions about stellar motion on the behavior of gravitational instabilities in protoplanetary disks around solar-type stars by performing two simulations that are identical in all respects except the treatment of the star. In one simulation, the star is assumed to remain fixed at the center of the inertial reference frame. In the other, stellar motion is handled properly by including an indirect potential in the hydrodynamic equations to model the star's reference frame as one which is accelerated by star/disk interactions. The disks in both simulations orbit a solar mass star, initially extend from 2.3 to 40 AU with a r^-1/2 surface density profile, and have a total mass of 0.14 M_sun. The gamma = 5/3 ideal gas is assumed to cool everywhere with a constant cooling time of two outer rotation periods. The overall behavior of the disk evolution is similar, except for weakening in various measures of GI activity by about at most tens of percent for the indirect potential case. Overall c...

  16. Locomotive and reptation motion induced by internal force and friction

    Science.gov (United States)

    Sakaguchi, Hidetsugu; Ishihara, Taisuke

    2011-06-01

    We propose a simple mechanical model of locomotion induced by internal force and friction. We first construct a system of two elements as an analog of the bipedal motion. The internal force does not induce a directional motion by itself because of the action-reaction law, but a directional motion becomes possible by the control of the frictional force. The efficiency of these model systems is studied using an analogy to the heat engine. As a modified version of the two-element model, we construct a model that exhibits a bipedal motion similar to kinesin’s motion of molecular motor. Next, we propose a linear chain model and a ladder model as an extension of the original two-element model. We find a transition from a straight to a snake-like motion in a ladder model by changing the strength of the internal force.

  17. Locomotive and reptation motion induced by internal force and friction

    OpenAIRE

    Sakaguchi, Hidetsugu; Ishihara, Taisuke

    2011-01-01

    We propose a simple mechanical model of locomotion induced by internal force and friction. We first construct a system of two elements as an analog of the bipedal motion. The internal force does not induce a directional motion by itself because of the action-reaction law, but a directional motion becomes possible by the control of the frictional force. The efficiency of these model systems is studied using an analogy to the heat engine. As a modified version of the two-elements model, we cons...

  18. Motion Induced by Light: Photokinetic Effects in the Rayleigh Limit

    CERN Document Server

    Ruffner, David B; Grier, David G

    2015-01-01

    Structured beams of light can move small objects in surprising ways. Particularly striking examples include observations of polarization-dependent forces acting on optically isotropic objects and tractor beams that can pull objects opposite to the direction of the light's propagation. Here we develop a theoretical framework in which these effects vanish at the leading order of light scattering theory. Exotic optical forces emerge instead from interference between different orders of multipole scattering. These effects create a rich variety of ways to manipulate small objects with light, so-called photokinetic effects. Applying this formalism to the particular case of Bessel beams offers useful insights into the nature of tractor beams and the interplay between spin and orbital angular momentum in vector beams of light, including a manifestation of orbital-to-spin conversion.

  19. Motion-induced synchronization in metapopulations of mobile agents

    CERN Document Server

    Gómez-Gardeñes, Jesús; Sinatra, Roberta; Latora, Vito

    2012-01-01

    We study the influence of motion on the emergence of synchronization in a metapopulation of random walkers moving on a heterogeneous network and subject to Kuramoto interactions at the network nodes. We discover a novel mechanism of transition to macroscopic dynamical order induced by the walkers' motion. Furthermore, we observe two different microscopic paths to synchronization: depending on the rules of the motion, either low-degree nodes or the hubs drive the whole system towards synchronization. We provide analytical arguments to understand these results.

  20. Synchronized Intermittent Motion Induced by the Interaction between Camphor Disks

    Science.gov (United States)

    Suematsu, Nobuhiko J.; Tateno, Kurina; Nakata, Satoshi; Nishimori, Hiraku

    2015-03-01

    A new mode of collective motion was discovered in a system of camphor disks floating on the water surface in a circular chamber. The mode was induced by tuning the number of the disks. A single or few disks are known to continuously move on the water surface. Conversely, when many disks are present, motion comes to a stop and the disks form ordered spatial patterns by repulsive interaction. Here we found the third mode that emerged at an intermediate disk number, in which inactive and active motion phases alternated non-periodically. This new mode exhibited synchronization as the disk number increased.

  1. Elastic image registration via rigid object motion induced deformation

    Science.gov (United States)

    Zheng, Xiaofen; Udupa, Jayaram K.; Hirsch, Bruce E.

    2011-03-01

    In this paper, we estimate the deformations induced on soft tissues by the rigid independent movements of hard objects and create an admixture of rigid and elastic adaptive image registration transformations. By automatically segmenting and independently estimating the movement of rigid objects in 3D images, we can maintain rigidity in bones and hard tissues while appropriately deforming soft tissues. We tested our algorithms on 20 pairs of 3D MRI datasets pertaining to a kinematic study of the flexibility of the ankle complex of normal feet as well as ankles affected by abnormalities in foot architecture and ligament injuries. The results show that elastic image registration via rigid object-induced deformation outperforms purely rigid and purely nonrigid approaches.

  2. 清代新疆地区纠纷调解机制与当代国家法的差异与融合--以《清代新疆档案选辑》为考察视角%The Differences and Fusion between Dispute Mediation System in Xinjiang Area, Qing Dynasty---Taking the Xinjiang Files Selection of Qing Dynasty as the Perspectives

    Institute of Scientific and Technical Information of China (English)

    范文博

    2014-01-01

    The Qing Dynasty is a period of which ancient mediation system improved more perfectly. This thesis intends to take the Xinjiang files selection of Qing Dynasty as the perspectives, analyzes the differences and fusion between dispute mediation system in Xinjiang area, Qing Dynasty, meanwhile, discusses its enlightenment on contemporary national law.%清代是古代调解制度发展较为完善的时期。以《清代新疆档案选辑》为考察视角,在分析清代新疆地区纠纷解决机制与当代国家法的差异和融合的同时,探讨其对当代国家法的启示作用。

  3. Inflammatory mediators in osteoarthritis

    OpenAIRE

    M Beekhuizen

    2014-01-01

    Osteoarthritis (OA) is a degenerative joint disorder involving cartilage destruction and joint inflammation. Despite extensive research, still much is unknown on the pathogenesis and aetiology of OA. Inflammation and inflammatory mediators (both local and systemic) are key in the pathogenesis of OA. For rheumatoid arthritis, multiple therapies are based on targeting the mediators that are associated with inflammation and joint destruction. Motivated by these findings we set off to identify wh...

  4. Interactive Mediated Reality

    OpenAIRE

    Grasset, Raphaël; Boissieux, Laurence; Gascuel, Jean-Dominique; Schmalstieg, Dieter

    2005-01-01

    International audience Mediated reality describes the concept of filtering our vision of reality, typically using a head-mounted video mixing display. We can redefine this idea in a more constructive context, applying dynamic changes to the appearance and geometry of objects in a real scene using computer graphics. In this paper, we propose new tools for interactively mediated reality. After describing a new generic framework for achieving this goal, we present a prototype system for paint...

  5. Chronic alloantibody mediated rejection

    OpenAIRE

    Smith, R. Neal; Colvin, Robert B.

    2011-01-01

    Alloantibodies clearly cause acute antibody mediated rejection, and all available evidence supports their pathogenic etiology in the development of chronic alloantibody mediated rejection (CAMR). But the slow evolution of this disease, the on-going immunosuppression, the variations in titer of alloantibodies, and variation in antigenic targets all complicate identifying which dynamic factors are most important clinically and pathologically. This review highlights the pathological factors rela...

  6. Area monitoring

    International Nuclear Information System (INIS)

    The exposure of individuals to ionizing radiation is normally subject to legal controls which specify limits, and restriction, of doses that both occupational workers and members of the public are exposed to. The dose limits recommended by the International Commission on Radiological Protection (ICRP), and adopted by many countries are specified in terms of body dose equivalents, sometimes referred to as limiting quantities. However these quantities are not measurable since they are defined as average doses in organs and tissues of the human body. Thus for the same physical radiation field the dose delivered to an individual will not have a fixed value but will depend upon each individual's sex, age and physical construction as well as upon their orientation in the field. Ionizing radiation, also, cannot be detected by a person's physical senses of sight, smell, hearing and touch. Thus to control the levels of radiation to which individuals are exposed, special operational quantities are used and quantitative measurements have to be made using personal dosemeters or area monitoring equipment. This report describes the operational quantities that are being increasingly used worldwide for area monitoring. It provides information on the international standards that are available on the performance requirements for monitoring equipment designed to measure these operational quantities. It also reviews the recent international standards that have been published on the calibration and type testing of area monitors and gives an example of legislative requirements on area monitoring equipment. (author)

  7. Effective Area

    Directory of Open Access Journals (Sweden)

    Ehud Keinan

    2015-07-01

    Full Text Available This article defines a new term, Effective Area, K, of a given territory as a function of four independent parameters: its nominal acreage, A, the intellectual competence of its inhabitants, B, their social competence, C, and their global influence, D, using a simple formalism: K = A x B x C x D. This analysis demonstrates that in our current world any consideration of the physical area of a given territory is meaningless if the quality of its population is ignored. K is a much more useful parameter than A, certainly for political and economical considerations, explaining why claims for territorial expansion are placed low on the national ladder of priorities in the developed countries. In many respects, large geographical areas may become a burden rather than an advantage. Thus, the importance of armed conflicts over geographical territories, which have taken a dominant part of the entire human history, is fading away. Furthermore, although the global acreage is constant, the total effective area of planet Earth keeps growing, providing sufficient room for the growing human population.

  8. Antibody-Mediated Lung Transplant Rejection

    Science.gov (United States)

    Hachem, Ramsey

    2012-01-01

    Antibody-mediated rejection after lung transplantation remains enigmatic. However, emerging evidence over the past several years suggests that humoral immunity plays an important role in allograft rejection. Indeed, the development of donor-specific antibodies after transplantation has been identified as an independent risk factor for acute cellular rejection and bronchiolitis obliterans syndrome. Furthermore, cases of acute antibody-mediated rejection resulting in severe allograft dysfunction have been reported, and these demonstrate that antibodies can directly injure the allograft. However, the incidence and toll of antibody-mediated rejection are unknown because there is no widely accepted definition and some cases may be unrecognized. Clearly, humoral immunity has become an important area for research and clinical investigation. PMID:23002428

  9. From Real Needs to Judicial Response:Research on the Mediation Judge Mode in Less Developed Rural Areas%由“现实需求”到“司法回应”--欠发达农村地区调解法官模式研究

    Institute of Scientific and Technical Information of China (English)

    田源; 李燕

    2014-01-01

    随着我国经济社会的飞速发展,农村地区的各类矛盾纠纷持续递增,影响了地方经济社会的和谐稳定。作为人民法院在农村地区的派驻机构,人民法庭承担着化解矛盾纠纷的重任。组建起一支与农村地区社会特点相适应的法官队伍,不仅是农村民众的共同现实需求,更是人民法院理应做出的司法回应。选取了S省D县人民法院作为分析样本,就欠发达农村地区调解法官模式的建构路径加以探究。%With the rapid economic and social development of our country , all kinds of contradictions and disputes in rural areas are growing ,affecting social stability .The people’s tribunal , as an agency of the People ’ s Court , undertakes the task of resolving conflicts and disputes . Establishing a group of judges adapt to the rural society is not only the common realistic demand of the rural people ,but also the judicial response the People’s Court should make .This paper selects the People’s Court of County D ,Province S as the analysis sample and explores the construction mode of mediation judges in less developed rural areas .

  10. [Immune-mediated neuropathies].

    Science.gov (United States)

    Stoll, G; Reiners, K

    2016-08-01

    The Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP) are the most common immune-mediated polyneuropathies, which can show variable clinical and electrophysiological manifestations. Rarer immune-mediated neuropathies encompass paraproteinemic neuropathies (PPN), multifocal motor neuropathy (MMN) and vasculitic neuropathies. The diagnosis usually relies on the history of symptom evolution, distribution of nerve dysfunction and particularly on characteristic features in nerve conduction studies, aided by cerebrospinal fluid (CSF) examination and nerve biopsy findings. The therapeutic toolbox encompasses corticosteroids, immunoglobulins and plasmapheresis often accompanied by long-term immunosuppression. It is important to note that immune-mediated neuropathies selectively respond to treatment and contraindications need to be considered. Despite treatment a considerable number of patients suffer from permanent neurological deficits. PMID:27474733

  11. The Strategic Mediator

    DEFF Research Database (Denmark)

    Rossignoli, Cecilia; Carugati, Andrea; Mola, Lapo

    2009-01-01

    The last 10 years have witnessed the emergence of electronic marketplaces as players that leverage new technologies to facilitate B2B internet-mediated collaborative business. Nowadays these players are augmenting their services from simple intermediation to include new inter-organizational relat......The last 10 years have witnessed the emergence of electronic marketplaces as players that leverage new technologies to facilitate B2B internet-mediated collaborative business. Nowadays these players are augmenting their services from simple intermediation to include new inter...... e-marketplace assumes the paradoxical role of strategic mediator: an agent who upholds and heightens the fences of the transactions instead of leveling them. The results have implication in shaping how we see the role of technology as strategic or commoditized....

  12. Immunologically mediated oral diseases

    Directory of Open Access Journals (Sweden)

    Sudha Jimson

    2015-01-01

    Full Text Available Immune mediated diseases of oral cavity are uncommon. The lesions may be self-limiting and undergo remission spontaneously. Among the immune mediated oral lesions the most important are lichen planus, pemphigus, erythema multiformi, epidermolysis bullosa, systemic lupus erythematosis. Cellular and humoral mediated immunity play a major role directed against epithelial and connective tissue in chronic and recurrent patterns. Confirmatory diagnosis can be made by biopsy, direct and indirect immunoflouresence, immune precipitation and immunoblotting. Therapeutic agents should be selected after thorough evaluation of immune status through a variety of tests and after determining any aggravating or provoking factors. Early and appropriate diagnosis is important for proper treatment planning contributing to better prognosis and better quality of life of patient.

  13. Immunologically mediated oral diseases.

    Science.gov (United States)

    Jimson, Sudha; Balachader, N; Anita, N; Babu, R

    2015-04-01

    Immune mediated diseases of oral cavity are uncommon. The lesions may be self-limiting and undergo remission spontaneously. Among the immune mediated oral lesions the most important are lichen planus, pemphigus, erythema multiformi, epidermolysis bullosa, systemic lupus erythematosis. Cellular and humoral mediated immunity play a major role directed against epithelial and connective tissue in chronic and recurrent patterns. Confirmatory diagnosis can be made by biopsy, direct and indirect immunoflouresence, immune precipitation and immunoblotting. Therapeutic agents should be selected after thorough evaluation of immune status through a variety of tests and after determining any aggravating or provoking factors. Early and appropriate diagnosis is important for proper treatment planning contributing to better prognosis and better quality of life of patient. PMID:26015713

  14. Mediatization Theory and Digital Media

    DEFF Research Database (Denmark)

    Finnemann, Niels Ole

    2011-01-01

    In the 20th century, the term "media logic" was introduced to denote the influence of independent mass media on political systems and other institutions. In recent years the idea has been reworked and labelled "mediatization" to widen the framework by including new media and new areas of...... new trajectories made possible by these media, which have led into a new media matrix built around the internet and mobile devices. It will be argued that the new media matrix cannot be understood from a point of view defined by the framework of 20th century mass media because digital media open new...... application.  In Section Two the paper discusses different conceptualizations. It is argued that even if they bring new insights, they cannot be unified into one concept, and that they also lack a consistent definition of digital media. Section three provides a definition of digital media in order to identify...

  15. Exploring general gauge mediation

    International Nuclear Information System (INIS)

    We explore various aspects of General Gauge Mediation (GGM). We present a reformulation of the correlation functions used in GGM, and further elucidate their IR and UV properties. Additionally we clarify the issue of UV sensitivity in the calculation of the soft masses in the MSSM, highlighting the role of the supertrace over the messenger spectrum. Finally, we present weakly coupled messenger models which fully cover the parameter space of GGM. These examples demonstrate that the full parameter space of GGM is physical and realizable. Thus it should be considered a valid basis for future phenomenological explorations of gauge mediation.

  16. Natural supersymmetric spectrum in mirage mediation

    OpenAIRE

    Asano, Masaki; Higaki, Tetsutaro

    2012-01-01

    Current results of LHC experiments exclude large area of light new particle region, namely natural parameter space, in supersymmetric extension models. One of the possibilities for achieving the correct electroweak symmetry breaking naturally is low scale messenger scenario. Actually, the next-to-minimal supersymmetric standard model with TeV scale mirage mediation realizes the natural electroweak symmetry breaking with various mass spectra. In this paper, we show the possible mass spectrum i...

  17. CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction

    OpenAIRE

    Tabeling, Christoph; Yu, Hanpo; Wang, Liming; Ranke, Hannes; Goldenberg, Neil M.; Zabini, Diana; Noe, Elena; Krauszman, Adrienn; Gutbier, Birgitt; Yin, Jun; Schaefer, Michael,; Arenz, Christoph; Hocke, Andreas C.; Suttorp, Norbert; Proia, Richard L.

    2015-01-01

    Hypoxic pulmonary vasoconstriction (HPV) is a physiological mechanism that protects against systemic hypoxemia by redistributing blood flow from poorly to better ventilated areas of the lung, thereby minimizing ventilation-perfusion mismatch. However, in chronic hypoxemia-associated lung disease, HPV contributes to pulmonary hypertension. In this study, we provide novel evidence for a dual role of sphingolipids as important signal mediators in HPV, which critically depends on the presence of ...

  18. Axionic Mirage Mediation

    CERN Document Server

    Nakamura, Shuntaro; Yamaguchi, Masahiro

    2008-01-01

    Although the mirage mediation is one of the most plausible mediation mechanisms of supersymmetry breaking, it suffers from two crucial problems. One is the \\mu-/B \\mu-problem and the second is the cosmological one. The former stems from the fact that the B parameter tends to be comparable with the gravitino mass, which is two order of magnitude larger than the other soft masses. The latter problem is caused by the decay of the modulus whose branching ratio into the gravitino pair is sizable. In this paper, we propose a model of mirage mediation, in which Peccei-Quinn symmetry is incorporated. In this \\textit{axionic mirage mediation}, it is shown that the PQ symmetry breaking scale is dynamically determined around 10^{10-12} GeV due to the supersymmetry breaking effects, and the \\mu-problem can be solved naturally. Furthermore, in our model, the lightest supersymmetric particle (LSP) is the axino, that is the superpartner of the axion. The overabundance of the LSPs due to decays of modulus/gravitino, which is...

  19. Inflammatory mediators in osteoarthritis

    NARCIS (Netherlands)

    Beekhuizen, M.

    2014-01-01

    Osteoarthritis (OA) is a degenerative joint disorder involving cartilage destruction and joint inflammation. Despite extensive research, still much is unknown on the pathogenesis and aetiology of OA. Inflammation and inflammatory mediators (both local and systemic) are key in the pathogenesis of OA.

  20. Thermally favourable gauge mediation

    International Nuclear Information System (INIS)

    We discuss the thermal evolution of the spurion and messenger fields of ordinary gauge mediation models taking into account the Standard Model degrees of freedom. It is shown that for thermalized messengers the metastable susy breaking vacuum becomes thermally selected provided that the susy breaking sector is sufficiently weakly coupled to messengers or to any other observable field.

  1. Den sundhedsfremmende mediator

    DEFF Research Database (Denmark)

    Læssøe, Jeppe

    2009-01-01

    mediering samt mellem forskellige mediator-roller og tilhørsforhold. Det er også vigtigt at være bevidst om de centrale kvaliteter, risici og dilemmaer, som mediering indebærer i forhold til involvering af borgerne. Denne artikel rummer et bud på en sådan nuanceret begrebsliggørelse og refleksion, relateret...

  2. Bradykinin-mediated angioedema.

    Science.gov (United States)

    Obtułowicz, Krystyna

    2016-02-01

    Angioedema and urticaria often constitute a challenge in daily clinical practice. They may either co- -occur or present as independent conditions. They are characterized by a complex pathomechanism, and their symptoms may be triggered by diverse factors. These differences are crucial for developing a successful treatment regimen. Both conditions may have an allergic origin (immunoglobulin [Ig] E and non-IgE-related), usually induced by histamine, or a nonallergic one, such as bradykinin-mediated angioedema in patients with C1 inhibitor (C1-INH) deficiency or angioedema induced by certain drugs (eg, angiotensin-converting enzyme inhibitors). Currently, we distinguish 5 types of nonallergic angioedema: hereditary angioedema (HAE) due to C1-INH deficiency, acquired angioedema (AAE), and angioedema induced by the renin-angiotensin-aldosterone system, all of which are mediated by bradykinin, as well as pseudoallergic angioedema and idiopathic angioedema. Bradykinin-mediated angioedema (eg, laryngeal angioedema) may be life-threatening because of resistance to corticosteroids and antihistamine drugs. C1-INH concentrates are the drugs of choice in the treatment of HAE and AAE. In recent years, some new drugs have been introduced in the treatment of bradykinin-mediated angioedema, such as bradykinin B2-receptor antagonist, icatibant, and kallikrein inhibitor, ecallantide, which allow to improve treatment outcomes. PMID:26842379

  3. Axionic mirage mediation

    International Nuclear Information System (INIS)

    Although mirage mediation is one of the most plausible mediation mechanisms of supersymmetry breaking, it suffers from two crucial problems. One is the μ/Bμ problem, and the second is the cosmological one. The former stems from the fact that the B parameter tends to be comparable with the gravitino mass, which is 2 orders of magnitude larger than the other soft masses. The latter problem is caused by the decay of the modulus whose branching ratio into the gravitino pair is sizable. In this paper, we propose a model of mirage mediation, in which Peccei-Quinn symmetry is incorporated. In this axionic mirage mediation, it is shown that the Peccei-Quinn symmetry breaking scale is dynamically determined around 1010 GeV to 1012 GeV due to the supersymmetry breaking effects, and the μ problem can be solved naturally. Furthermore, in our model, the lightest supersymmetric particle (LSP) is the axino, that is, the superpartner of the axion. The overabundance of the LSPs due to decays of the modulus/gravitino, which is the most serious cosmological difficulty in the mirage mediation, can be avoided if the axino is sufficiently light. The next-LSPs (NLSPs) produced by the gravitino decay eventually decay into the axino LSPs, yielding the dominant component of the axinos remaining today. It is shown that the axino with a mass of O(100) MeV is naturally realized, which can constitute the dark matter of the Universe, with a free-streaming length of the order of 0.1 Mpc. The saxion, the real scalar component of the axion supermultiplet, can also be cosmologically harmless due to the dilution of the modulus decay. The lifetime of the NLSP is relatively long, but much shorter than 1 sec, when the big-bang nucleosynthesis commences. The decay of the NLSP would provide intriguing collider signatures

  4. Mediation Analysis with Principal Stratification

    OpenAIRE

    Gallop, Robert; Small, Dylan; Lin, Julia Y.; Elliot, Michael R.; Joffe, Marshall; Ten Have, Thomas R.

    2009-01-01

    In assessing the mechanism of treatment efficacy in randomized clinical trials, investigators often perform mediation analyses by analyzing if the significant intent-to-treat treatment effect on outcome occurs through or around a third intermediate or mediating variable: indirect and direct effects, respectively. Standard mediation analyses assume sequential ignorability, i.e., conditional on covariates the intermediate or mediating factor is randomly assigned, as is the treatment in a random...

  5. Models as Mediators

    DEFF Research Database (Denmark)

    Sommerlund, Julie

    from laboratory studies, (Latour 1979; Lynch 1985; Sommerlund 2004 (2007); Sommerlund 2006) and is complemented by the attention paid to the "mediator" by Hennion (1989; 1997; 2005). The empirical focus will be on a central - but overlooked - actor of branding and advertising; the model. The model has...... solely been theorized within cultural studies (Craik 1994) as feminine spectacle, but has been neglected as mediator and actor. This paper will argue that models are co-producers of brands, and vice versa. Empirically, the paper will present interviews with models, model-scouts, agents, and advertisers...... using models in branding-campaigns. The paper will contribute to the field of cultural economy by extending the productive methodology of STS into the fields of branding and marketing, and to the understanding of branding and marketing by focusing on an understudied phenomena - the model - and by...

  6. Fashion, Mediations & Method Assemblages

    DEFF Research Database (Denmark)

    Sommerlund, Julie; Jespersen, Astrid Pernille

    , it is an important ambition of this paper to go into a methodological discussion of how "that which effectively happens" can be approached. To this end, the paper will combine Hennion's term of the "mediator" with John Laws methodological term of "method assemblages". Method assemblages is a suggested as a way...... relations between individuals and social contexts, aesthetics and production, distribution and consumption, as well as relations between fluidity and stability. By addressing the field of fashion, the paper proposes to shed light on an empirical setting which has so far been studied either as a purely...... - Domestication of the Scallops and Fishermen of St. Brieuc Bay. Power, Action, and Belief - A New Sociology of Knowledge. J. Law. London, Routledge and Keagan Paul: 196-233. Hennion, A. (1997). "Baroque and rock: Music, mediators and musical taste." Poetics 24: 414 - 435. Latour, B. (1993). We Have Never Been...

  7. Direct Gaugino Mediation

    International Nuclear Information System (INIS)

    We describe renormalizable supersymmetric four-dimensional theories which lead to gaugino mediation and various generalizations thereof. Even though these models are strongly coupled, we can demonstrate the parametric suppression of soft scalar masses via Seiberg duality. We show that our models have a parameter which continuously interpolates between suppressed soft scalar masses and their conventional gauge mediated contribution. The main physical effect which we utilize is the general relation between massive deformations in one frame and the Higgs mechanism in the dual frame. Some compelling and relatively unexplored phenomenological scenarios arise naturally in this framework. We offer preliminary comments on various aspects of the phenomenology and outline several of the outstanding open problems.

  8. Minimal gaugino mediation

    International Nuclear Information System (INIS)

    We propose minimal gaugino mediation as the simplest known solution to the supersymmetric flavor and CP problems. The framework predicts a very minimal structure for the soft parameters at ultrahigh energies: gaugino masses are unified and non-vanishing whereas all other soft supersymmetry breaking parameters vanish. We show that this boundary condition naturally arises from a small extra dimension and present a complete model which includes a new extra-dimensional solution to the μ problem. We briefly discuss the predicted superpartner spectrum as a function of the two parameters of the model. The commonly ignored renormalization group evolution above the GUT scale is crucial to the viability of minimal gaugino mediation but does not introduce new model dependence

  9. Minimal Gaugino Mediation

    International Nuclear Information System (INIS)

    The authors propose Minimal Gaugino Mediation as the simplest known solution to the supersymmetric flavor and CP problems. The framework predicts a very minimal structure for the soft parameters at ultra-high energies: gaugino masses are unified and non-vanishing whereas all other soft supersymmetry breaking parameters vanish. The authors show that this boundary condition naturally arises from a small extra dimension and present a complete model which includes a new extra-dimensional solution to the mu problem. The authors briefly discuss the predicted superpartner spectrum as a function of the two parameters of the model. The commonly ignored renormalization group evolution above the GUT scale is crucial to the viability of Minimal Gaugino Mediation but does not introduce new model dependence

  10. Amplitude mediated chimera states

    OpenAIRE

    Sethia, Gautam C.; Sen, Abhijit; Johnston, George L.

    2013-01-01

    We investigate the possibility of obtaining chimera state solutions of the non-local Complex Ginzburg-Landau Equation (NLCGLE) in the strong coupling limit when it is important to retain amplitude variations. Our numerical studies reveal the existence of a variety of amplitude mediated chimera states (including stationary and non-stationary two cluster chimera states), that display intermittent emergence and decay of amplitude dips in their phase incoherent regions. The existence regions of t...

  11. Teachers as mediators

    DEFF Research Database (Denmark)

    Dorf, Hans; Kelly, Peter; Hohmann, Ulrike;

    2012-01-01

    Within the context of lower secondary English teaching in South West England, this study identifies in broad terms the competing goals between which English teachers mediate and the explicit and hidden tensions that result. To understand the interactions of competing goals, teachers’ goal...... cultural influences on practice. Yet the teachers observed moved smoothly between goal-oriented behaviours in a continuous and comfortable style, easily and without reflecting any tensions between them. Thus, this article elaborates an account of situated English teaching....

  12. An Alternative Framework for Defining Mediation.

    Science.gov (United States)

    Collins, Linda M.; Graham, John W.; Flaherty, Brian P.

    1998-01-01

    Presents an alternative framework for evaluating mediated relationships. The distinguishing feature of mediation is that mediation involves a chain reaction. The definition presented emphasizes the intra-individual, time-ordered nature of mediation. (SLD)

  13. 45 CFR 16.18 - Mediation.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Mediation. 16.18 Section 16.18 Public Welfare... BOARD § 16.18 Mediation. (a) In cases pending before the Board. If the Board decides that mediation... mediation techniques and will provide or assist in selecting a mediator. The mediator may take any...

  14. Immunologically mediated abortion (IMA).

    Science.gov (United States)

    Giacomucci, E; Bulletti, C; Polli, V; Prefetto, R A; Flamigni, C

    1994-06-01

    Roughly 20% of all clinical pregnancies evolve into "spontaneous abortions". The causes of spontaneous abortion have been determined in under 60% of the total and comprise genetic, infectious, hormonal and immunological factors. In some cases the immune tolerance mechanism may be impaired and the foetus immunologically rejected (IMA, immunologically mediated abortion). The immunological mechanism implicated depends on the time in which pregnancy loss takes place. During preimplantation and up to the end of implantation (13th day) the cell-mediated immune mechanism (potential alloimmune etiologies) is responsible for early abortion. This mechanism involves immunocompetent decidual cells (eGL, endometrial granulated lymphocytes) already present during pre-decidualization (late luteal phase) and their production of soluble factors or cytokines. Once the implantation process is over, after blastocyst penetration of the stroma and the decidual reaction of uterine tissue, IMA could be caused by cell-mediated and humoral mechanism (anti-paternal cytotoxic antibodies or autoantibody etiology), by the production of paternal anti major histocompatibility complex antibodies, or even by an autoimmune disorder leading to the production of autoantibodies (antiphospholipid antibodies, antinuclear antibodies or polyclonal B cell activation). The diagnostic work-up adopted to select IMA patients is crucial and includes primary (karyotype of both partners, toxo-test, hysterosalpingography, endometrial biopsy, thyroid function tests, serum hprolactin, luteal phase dating) and secondary (full hemochromocytometric test, search for LE cells, lupus anticoagulant, anticardiolipin, antinuclear antibodies, Rheumatoid factor, blood complement VDRL) investigations. Therapeutical approaches vary. If autoimmune disorders are demonstrated therapies with different combinations of corticosteroids, aspirin and heparin or intravenous immunoglobulin are administered. Otherwise, therapy with paternal

  15. Sociocultural mediators of remembering

    DEFF Research Database (Denmark)

    Wagoner, Brady; Gillespie, Alex

    2014-01-01

    , questioning and deferring contribute to the transformation and conventionalization of the material. These diverse sociocultural mediators are integrated into a partially coherent recollection by participants self-reflecting, or as Bartlett termed it, turning around upon their schemas. We demonstrate that this...... self-reflection is both a social and a psychological process, occurring because participants are responding to their own utterances in the same way that they respond to the utterances of other people. These empirical findings are used to make a case for using discursive data to look not only at...

  16. Structure-mediated nanoscopy

    DEFF Research Database (Denmark)

    Glückstad, Jesper; Bañas, Andrew Rafael; Aabo, Thomas;

    2013-01-01

    optical trapping handles for convenient mechanical control using only optical forces [6]. These microstructures can be effectively handled with simultaneous top- and side-view on our BioPhotonics Workstation to carry out proof-of-principle experiments illustrating the six-degree-of-freedom optical...... structures with built-in waveguides for us, we were able to put the idea of optically steerable freestanding waveguides – coined: wave-guided optical waveguides - to the test using our BioPhotonics Workstation [7]. We also proposed designing micro-structures for so-called structure-mediated access to the...

  17. Ferrofluid mediated nanocytometry.

    Science.gov (United States)

    Kose, Ayse Rezzan; Koser, Hur

    2012-01-01

    We present a low-cost, flow-through nanocytometer that utilizes a colloidal suspension of non-functionalized magnetic nanoparticles for label-free manipulation and separation of microparticles. Our size-based separation is mediated by angular momentum transfer from magnetically excited ferrofluid particles to microparticles. The nanocytometer is capable of rapidly sorting and focusing two or more species, with up to 99% separation efficiency and a throughput of 3 × 10(4) particles/s per mm(2) of channel cross-section. The device is readily scalable and applicable to live cell sorting with biocompatible ferrofluids, offering competitive cytometer performance in a simple and inexpensive package. PMID:22076536

  18. Mediation Revisited: The Interactive Organization of Mediation in Learning Environments

    OpenAIRE

    Pekarek Doehler, Simona

    2013-01-01

    This article is concerned with the social organization of mediation in learning environments. It seeks to further articulate the sociocultural notion of mediation in sociointeractional terms, combining insights from the sociocultural approach to cognition and the microinteractionist, especially ethnomethodological approach to social activities. A microanalysis of mediation in communicative 2nd-language classroom activities where the task at hand is the management of interaction itself is pres...

  19. The Simulation of the Influenza Transmission Dynamics in Tropical Area and Subtropical Area in East Asia

    Institute of Scientific and Technical Information of China (English)

    YANG Gong-li

    2014-01-01

    The underlying theory of the summer influenza transmission peaks in tropical area and subtropical area in East Asia is still unclear. We built an agent-based model (ABM) to simulate the influenza transmission dynamics. We modeled two main routes of influenza transmission in the model: the aerosol route and the fomite-mediated route. Our results show that the absolute humidity (AH) is strikingly associated with the influenza transmission in different season; Fomite-mediated route particularly plays an important role in influenza transmission, the two-route transmission model can be better used for explaining the summer transmission peaks.

  20. Enable, mediate, advocate.

    Science.gov (United States)

    Saan, Hans; Wise, Marilyn

    2011-12-01

    The authors of the Ottawa Charter selected the words enable, mediate and advocate to describe the core activities in what was, in 1986, the new Public Health. This article considers these concepts and the values and ideas upon which they were based. We discuss their relevance in the current context within which health promotion is being conducted, and discuss the implications of changes in the health agenda, media and globalization for practice. We consider developments within health promotion since 1986: its central role in policy rhetoric, the increasing understanding of complexities and the interlinkage with many other societal processes. So the three core activities are reviewed: they still fit well with the main health promotion challenges, but should be refreshed by new ideas and values. As the role of health promotion in the political arena has grown we have become part of the policy establishment and that is a mixed blessing. Making way for community advocates is now our challenge. Enabling requires greater sensitivity to power relations involved and an understanding of the role of health literacy. Mediating keeps its central role as it bridges vital interests of parties. We conclude that these core concepts in the Ottawa Charter need no serious revision. There are, however, lessons from the last 25 years that point to ways to address present and future challenges with greater sensitivity and effectiveness. We invite the next generation to avoid canonizing this text: as is true of every heritage, the heirs must decide on its use. PMID:22080073

  1. Semi-direct gauge mediation

    International Nuclear Information System (INIS)

    We describe a framework for gauge mediation of supersymmetry breaking in which the messengers are charged under the hidden sector gauge group but do not play a role in breaking supersymmetry. From this point of view, our framework is between ordinary gauge mediation and direct mediation. As an example, we consider the 3-2 model of dynamical supersymmetry breaking, and add to it massive messengers which are SU(2) doublets. We briefly discuss the phenomenology of this scenario.

  2. Mediating Trust in Terrorism Coverage

    DEFF Research Database (Denmark)

    Mogensen, Kirsten

    crisis. While the framework is presented in the context of television coverage of a terror-related crisis situation, it can equally be used in connection with all other forms of mediated trust. Key words: National crisis, risk communication, crisis management, television coverage, mediated trust.......Mass mediated risk communication can contribute to perceptions of threats and fear of “others” and/or to perceptions of trust in fellow citizens and society to overcome problems. This paper outlines a cross-disciplinary holistic framework for research in mediated trust building during an acute...

  3. Mediatization and Government Communication

    DEFF Research Database (Denmark)

    Laursen, Bo; Valentini, Chiara

    2015-01-01

    communication efforts, and that they face a daily professional challenge as they attempt to promote the European Parliament and its activities to the news media in a way that will not compromise their credibility as government sources. The study provides new insights into communicative aspects of EU governance......Social actors see exposure in the news media as attractive for publicity purposes and are under pressure to adapt their press work to a “media logic” to be attractive sources for journalists and editors. This article investigates the European Parliament’s press officers’ professional practices in...... the light of mediatization and government communication theories. Without one pan-European public sphere, the European Parliament, like the other European Union (EU) institutions, competes with national actors for the news media’s attention in the EU’s twenty-eight national public spheres, where EU...

  4. When Memories are Mediated

    DEFF Research Database (Denmark)

    Frølunde, Lisbeth; Bjerregaard, Mette

    2013-01-01

    Acts of mass violence, including murder on civilians, genocide, oppression and wars, can mobilize memories of the involved persons and following generations in a certain historical situation. Acts of mass violence can also create a sort of looking glass of culturally dominant memories that are...... political contexts and media platforms take place and become contexts for audience reception. This paper explores two examples of narratives that construct memories of acts of mass violence: “Gzim Rewind” (Sweden, 2011, director Knutte Wester) about 1990’s Kosovo, and “The Act of Killing” (Denmark, 2012...... mediated through stories: told and retold as oral stories through generations, as myths or sagas, or remediated as contemporary documentary film accounts or more fictional film accounts. In these processes of retelling acts of violence, transformations of meanings across time, cultural, social and...

  5. Mediated Cultural Memories

    DEFF Research Database (Denmark)

    Frølunde, Lisbeth; Bjerregaard, Mette

    2013-01-01

    generations. Acts of mass violence also construct a sort of looking glass of culturally dominant memories that are mediated through stories: retold as oral stories through generations, as myths or sagas, or remediated in contemporary documentary or fiction films. In these processes of retelling acts of...... violence, there are transformations of meanings across time, media, cultural, social and political contexts – which influence audience reception. The theoretical perspectives are on the construction of meaning-making, culture, and self as dialogic (Bakhtin) and socially constructed (Gergen), and on media......(A revised, full paper will be published in the journal Mediekultur, spring 2014) This paper explores two examples of narratives representing memories of acts of mass violence: Gzim Rewind (Sweden, 2011, director Knutte Wester) about 1990’s Kosovo, and The Act of Killing (Denmark, 2012, director...

  6. Neutrino assisted gauge mediation

    International Nuclear Information System (INIS)

    Recent observation shows that the Higgs mass is at around 125 GeV while the prediction of the minimal supersymmetric standard model is below 120 GeV for stop mass lighter than 2 TeV unless the top squark has a maximal mixing. We consider the right-handed neutrino supermultiplets as messengers in addition to the usual gauge mediation to obtain sizeable trilinear soft parameters At needed for the maximal stop mixing. Neutrino messengers can explain the observed Higgs mass for stop mass around 1 TeV. Neutrino assistance can also generate charged lepton flavor violation including μ→e γ as a possible signature of the neutrino messengers. We consider the S4 discrete flavor model and show the relation of the charged lepton flavor violation, θ 13 of neutrino oscillation and the muon's g-2. (orig.)

  7. Mediation and managed care.

    Science.gov (United States)

    Dubler, N N

    1998-03-01

    Managed care has not only intensified existing conflicts between patient and provider, it has, by its very nature, changed the shape and scope of the healthcare enterprise and introduced an entirely new set of disputes. The decision-making dynamics have been altered, and the cast of players has expanded. Traditionally, the therapeutic interaction took place between the physician and the patient although it occasionally included the patient's family. Whatever obligations existed, such as fidelity, confidentiality, and standard of care, they bound only those parties. Now, as the managed care organization has interposed itself between the patient and the physician, the dyad has become a triad. The power balance has shifted, and a new set of rights and responsibilities now flows between and among the players, each of whom has interests that may or may not coincide. This article argues that, because of its cost containment origins and orientation, managed care increases the likelihood that misunderstandings, disagreements and disputes will develop into full-blown conflicts. If managed care is to succeed financially and operate with integrity, it must develop techniques for managing the increasing conflicts that arise inevitably between and among the organizations, physicians, and patients. It is clear that the voice of the patient needs to be strengthened within the new complex decision-making, review, and appeal procedures. Mediation is the most appropriate method of dispute resolution for the managed care setting because it balances the disparities in power endemic to the bureaucratization of medicine and refocuses the interests of the various parties. Using bioethics consultation as a model for dispute mediation provides a set of principles and guideline tasks that can be applied effectively to managed care. PMID:9514387

  8. Natural supersymmetric spectrum in mirage mediation

    Science.gov (United States)

    Asano, Masaki; Higaki, Tetsutaro

    2012-08-01

    The current results of LHC experiments exclude a large area of the light new particle region, namely, natural parameter space, in supersymmetric extension models. One of the possibilities for achieving the correct electroweak symmetry breaking naturally is the low-scale messenger scenario. Actually, the next-to-minimal supersymmetric standard model with TeV scale mirage mediation realizes the natural electroweak symmetry breaking with various mass spectra. In this paper, we show the possible mass spectrum in the scenario, e.g., the degenerate and/or hierarchical mass spectrum, and discuss these features.

  9. Natural supersymmetric spectrum in mirage mediation

    CERN Document Server

    Asano, Masaki

    2012-01-01

    Current results of LHC experiments exclude large area of light new particle region, namely natural parameter space, in supersymmetric extension models. One of the possibilities for achieving the correct electroweak symmetry breaking naturally is low scale messenger scenario. Actually, the next-to-minimal supersymmetric standard model with TeV scale mirage mediation realizes the natural electroweak symmetry breaking with various mass spectra. In this paper, we show the possible mass spectrum in the scenario, e.g. degenerate and/or hierarchical mass spectrum, and discuss these features.

  10. The mediation procedure in Romania

    Directory of Open Access Journals (Sweden)

    Alexandrina Zaharia

    2009-06-01

    Full Text Available The mediation activity as an alternative way of solving conflicts occupies an important place in modernsociety. Currently, the mediation reached its maturity worldwide being adopted without reservations.The future of solving conflicts is undoubtedly closely related to mediation. XXth century is the century of solvingconflicts amiably outside the court room. In Romania and the mediation profession were regulated by the Law no.192/2006, on the basis of the idea that mediation is one of the major themes of the reform strategy of the judicialsystem 2005-2007. By adopting the mentioned law it was followed the idea of reducing the volume of activitycourts, and therefore, relieve them of as many cases, with the direct effect on the quality of justice. Mediation is avoluntary process in which the parties with a neutral and impartial third party, without power of decision - themediator - who is qualified to assist the parties to negotiate, facilitating the communication between them andhelping them to reach a unanimous effective and sustainable agreement. The parties may resort to mediation beforeor after triggering a trial. Mediation can be applied, in principle, on any type of conflict. However, theRomanian legislator has established special stipulations on conflict mediation in criminal, civil and familylaw. Although not expressly provided, the stipulations regarding the civil conflicts and also apply to commercialconflicts. Therefore, the mediation is applicable to most types of lawsuits, except those relating to personalrights. As a "win- win" principle, the mediation does not convert any of the parties defeated or victorious; allthose involved have gained by applying this procedure.

  11. FHFA Underserved Areas

    Data.gov (United States)

    Department of Housing and Urban Development — Federal Housing Finance Agency's (FHFA) Underserved Areas establishes underserved area designations for census tracts in Metropolitan Areas (MSAs), nonmetropolitan...

  12. Anomaly mediation deformed by axion

    International Nuclear Information System (INIS)

    We show that in supersymmetric axion models the axion supermultiplet obtains a sizable F-term due to a non-supersymmetric dynamics and it generally gives the gaugino masses comparable to the anomaly mediation contribution. Thus the gaugino mass relation predicted by the anomaly mediation effect can be significantly modified in the presence of axion to solve the strong CP problem

  13. Assay of mast cell mediators

    DEFF Research Database (Denmark)

    Rådinger, Madeleine; Jensen, Bettina M; Swindle, Emily;

    2015-01-01

    Mediator release from activated mast cells is a major initiator of the symptomology associated with allergic disorders such as anaphylaxis and asthma. Thus, methods to monitor the generation and release of such mediators have widespread applicability in studies designed to understand the processe...

  14. Comments on general gauge mediation

    International Nuclear Information System (INIS)

    There has been interest in generalizing models of gauge mediation of supersymmetry breaking. As shown by Meade, Seiberg, and Shih (MSS), the soft masses of general gauge mediation can be expressed in terms of the current two-point functions of the susy-breaking sector. We here give a simple extension of their result which provides, for general gauge mediation, the full effective potential for squark pseudo-D-flat directions. The effective potential reduces to the sfermion soft masses near the origin, and the full potential, away from the origin, can be useful for cosmological applications. We also generalize the soft masses and effective potential to allow for general gauge mediation by Higgsed gauge groups. Finally, we discuss general gauge mediation in the limit of small F-terms, and how the results of MSS connect with the analytic continuation in superspace results, based on a spurion analysis.

  15. Practical Guide to Civil Mediation

    CERN Multimedia

    2006-01-01

    The Permanent Mission of Switzerland has informed CERN that the Département des Institutions of the Republic and Canton of Geneva and the Groupement suisse des Magistrats pour la médiation (GEMME) - Swiss Association of Magistrates for Mediation have published a multilingual Practical Guide to Civil Mediation (including English). In this context, the Swiss Mission has underlined the benefits of resorting to mediation, especially for the personnel of international organizations, and which the Secretary-General of the GEMME has summarised as follows: it is a private process not requiring the waiver of the parties' immunities; the confidentiality of the mediation process is guaranteed both by the mediator and the parties to it; the search for an amicable settlement does not need to be determined by reference to law (provided that public order is respected); the process is faster (2 to 3 sessions), less costly and more flexible than civil or arbitration procedures; in order to reinforce the agreeme...

  16. Practical Guide to Civil Mediation

    CERN Multimedia

    2006-01-01

    The Permanent Mission of Switzerland has informed CERN that the Département des Institutions of the Republic and Canton of Geneva and the Groupement suisse des Magistrats pour la médiation (GEMME) - Swiss Association of Magistrates for Mediation have published a multilingual Practical Guide to Civil Mediation (including English). In this context, the Swiss Mission has underlined the benefits of resorting to mediation, especially for the personnel of International Organizations, and which the Secretary-General of the GEMME has summarised as follows: it is a private process not requiring the waiver of the parties' immunities; the confidentiality of the mediation process is guaranteed both by the mediator and the parties to it; the search for an amicable settlement does not need to be determined by reference to law (provided that public order is respected); the process is faster (2 to 3 sessions), less costly and more flexible than civil or arbitration procedures; in order to reinforce the agreem...

  17. 29 CFR 35.32 - Mediation.

    Science.gov (United States)

    2010-07-01

    ... Mediation. (a) Referral to mediation. CRC will promptly refer to the Federal Mediation and Conciliation Service or the mediation agency designated by the Secretary of Health and Human Services under 45 CFR part... 29 Labor 1 2010-07-01 2010-07-01 true Mediation. 35.32 Section 35.32 Labor Office of the...

  18. 29 CFR 1202.1 - Mediation.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Mediation. 1202.1 Section 1202.1 Labor Regulations Relating to Labor (Continued) NATIONAL MEDIATION BOARD RULES OF PROCEDURE § 1202.1 Mediation. The mediation..., or where conferences are refused. The National Mediation Board may proffer its services in case...

  19. 24 CFR 3288.35 - Mediation.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Mediation. 3288.35 Section 3288.35...-Administered States § 3288.35 Mediation. (a) Mediator. The dispute resolution provider will provide for the... identifies any other party that should be included in the mediation, the mediator will contact the...

  20. 29 CFR 1203.1 - Mediation services.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Mediation services. 1203.1 Section 1203.1 Labor Regulations Relating to Labor (Continued) NATIONAL MEDIATION BOARD APPLICATIONS FOR SERVICE § 1203.1 Mediation services. Applications for the mediation services of the National Mediation Board under section 5, First, of the...

  1. 22 CFR 143.33 - Mediation.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Mediation. 143.33 Section 143.33 Foreign... Mediation. (a) Referral of complaints for mediation. The agency will refer to the Federal Mediation and... participate in the mediation process to the extent necessary to reach an agreement or make an...

  2. 34 CFR 81.13 - Mediation.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Mediation. 81.13 Section 81.13 Education Office of the... Mediation. (a) Voluntary mediation is available for proceedings that are pending before the OALJ. (b) A... mediation by filing a motion with the ALJ assigned to the case. The OALJ arranges for a mediator if...

  3. 32 CFR 776.38 - Mediation.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Mediation. 776.38 Section 776.38 National... Professional Conduct § 776.38 Mediation. (a) Mediation: (1) A covered attorney may act as a mediator between... mediation, including the advantages and risks involved, and the effect on the...

  4. 44 CFR 7.942 - Mediation.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Mediation. 7.942 Section 7..., Conciliation, and Enforcement Procedures § 7.942 Mediation. (a) FEMA will promptly refer to a mediation agency... participate in the mediation process to the extent necessary to reach an agreement or for the mediator to...

  5. Microbially mediated mineral carbonation

    Science.gov (United States)

    Power, I. M.; Wilson, S. A.; Dipple, G. M.; Southam, G.

    2010-12-01

    Mineral carbonation involves silicate dissolution and carbonate precipitation, which are both natural processes that microorganisms are able to mediate in near surface environments (Ferris et al., 1994; Eq. 1). (Ca,Mg)SiO3 + 2H2CO3 + H2O → (Ca,Mg)CO3 + H2O + H4SiO4 + O2 (1) Cyanobacteria are photoautotrophs with cell surface characteristics and metabolic processes involving inorganic carbon that can induce carbonate precipitation. This occurs partly by concentrating cations within their net-negative cell envelope and through the alkalinization of their microenvironment (Thompson & Ferris, 1990). Regions with mafic and ultramafic bedrock, such as near Atlin, British Columbia, Canada, represent the best potential sources of feedstocks for mineral carbonation. The hydromagnesite playas near Atlin are a natural biogeochemical model for the carbonation of magnesium silicate minerals (Power et al., 2009). Field-based studies at Atlin and corroborating laboratory experiments demonstrate the ability of a microbial consortium dominated by filamentous cyanobacteria to induce the precipitation of carbonate minerals. Phototrophic microbes, such as cyanobacteria, have been proposed as a means for producing biodiesel and other value added products because of their efficiency as solar collectors and low requirement for valuable, cultivable land in comparison to crops (Dismukes et al., 2008). Carbonate precipitation and biomass production could be facilitated using specifically designed ponds to collect waters rich in dissolved cations (e.g., Mg2+ and Ca2+), which would allow for evapoconcentration and provide an appropriate environment for growth of cyanobacteria. Microbially mediated carbonate precipitation does not require large quantities of energy or chemicals needed for industrial systems that have been proposed for rapid carbon capture and storage via mineral carbonation (e.g., Lackner et al., 1995). Therefore, this biogeochemical approach may represent a readily

  6. Caspases: An apoptosis mediator

    Directory of Open Access Journals (Sweden)

    Tapan Kumar Palai

    2015-03-01

    Full Text Available The process of programmed cell death, or apoptosis, is generally characterized by distinct morphological characteristics and energy - dependent biochemical mechanisms. Apoptosis is a widely conserved phenomenon helping many processes, including normal cell turnover, proper development and functioning of the immune system, hormone dependent atrophy etc. Inappropriate apoptosis (either low level or high level leads to many developmental abnormalities like, neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of cancer. To use cells for therapeutic purposes through generating cell lines, it is critical to study the cell cycle machinery and signalling pathways that controls cell death and apoptosis. Apoptotic pathways provide a fundamental protective mechanism that decreases cellular sensitivity to damaging events and allow proper developmental process in multi-cellular organisms. Major mediator of apoptosis is a family of proteins known as caspases. There are mainly fourteen types of caspases but out of them only ten caspasese have got essential role in controlling the process of apoptosis. These ten caspases have been categorized into either initiator caspases (caspase 2, 8, 9, 10 or executioner caspases (caspase 3, 6, 7. Although various types of caspases have been identified so far, the exact mechanisms of action of these groups of proteins is still to be fully understood. The aim of this review is to provide a detail overview of role of different caspases in regulating the process of apoptosis.

  7. Ultrasound mediated gene transfection

    Science.gov (United States)

    Williamson, Rene G.; Apfel, Robert E.; Brandsma, Janet L.

    2002-05-01

    Gene therapy is a promising modality for the treatment of a variety of human diseases both inherited and acquired, such as cystic fibrosis and cancer. The lack of an effective, safe method for the delivery of foreign genes into the cells, a process known as transfection, limits this effort. Ultrasound mediated gene transfection is an attractive method for gene delivery since it is a noninvasive technique, does not introduce any viral particles into the host and can offer very good temporal and spatial control. Previous investigators have shown that sonication increases transfection efficiency with and without ultrasound contrast agents. The mechanism is believed to be via a cavitation process where collapsing bubble nuclei permeabilize the cell membrane leading to increased DNA transfer. The research is focused on the use of pulsed wave high frequency focused ultrasound to transfect DNA into mammalian cells in vitro and in vivo. A better understanding of the mechanism behind the transfection process is also sought. A summary of some in vitro results to date will be presented, which includes the design of a sonication chamber that allows us to model the in vivo case more accurately.

  8. MANDATORY CLAUSES IN MEDIATION CONTRACTS

    Directory of Open Access Journals (Sweden)

    VERONICA STOICA

    2011-04-01

    Full Text Available The mediation contract – a contract by which conflicting parties agree, in conjunction with a mediator, upon conflict resolve in an amiable manner through the agency of mediation, under due efforts on the mediator’s part, in exchange for payment of a fee by the parties – must contain a set of mandatory clauses in compliance with legal provisions, Article 45 of Law no. 192/2006. In the absence of one of said clauses, sanction by absolute annulment is imposed.

  9. Doing statistical mediation and moderation

    CERN Document Server

    Jose, Paul E

    2013-01-01

    Written in a friendly, conversational style, this book offers a hands-on approach to statistical mediation and moderation for both beginning researchers and those familiar with modeling. Starting with a gentle review of regression-based analysis, Paul Jose covers basic mediation and moderation techniques before moving on to advanced topics in multilevel modeling, structural equation modeling, and hybrid combinations, such as moderated mediation. User-friendly features include numerous graphs and carefully worked-through examples; ""Helpful Suggestions"" about procedures and pitfalls; ""Knowled

  10. Mediator-Generated Pressure Tactics

    Science.gov (United States)

    Byrnes, Joseph F.

    1978-01-01

    Two examples of bluff pressures (as opposed to real pressures) used by mediators to effect contract settlements are presented, along with advice to negotiators on avoiding or minimizing such tactics. (Author/IRT)

  11. Gauge mediation in string theory

    OpenAIRE

    Kawano, Teruhiko; Ooguri, Hirosi; Ookouchi, Yutaka

    2007-01-01

    We show that a large class of phenomenologically viable models for gauge mediation of supersymmetry breaking based on meta-stable vacua can be realized in local Calabi–Yau compactifications of string theory.

  12. Bradykinin-mediated diseases.

    Science.gov (United States)

    Kaplan, Allen P

    2014-01-01

    Diseases which have been demonstrated to be caused by increased plasma levels of bradykinin all have angioedema as the common major clinical manifestation. Angioedema due to therapy with angiotensin-converting enzyme (ACE) inhibitors is caused by suppressed bradykinin degradation so that it accumulates. This occurs because ACE metabolizes bradykinin by removal of Phe-Arg from the C-terminus, which inactivates it. By contrast, angioedema due to C1 inhibitor deficiency (either hereditary types I and II, or acquired) is caused by bradykinin overproduction. C1 inhibitor inhibits factor XIIa, kallikrein and activity associated with the prekallikrein-HK (high-molecular-weight kininogen) complex. In its absence, uncontrolled activation of the plasma bradykinin cascade is seen once there has been an initiating stimulus. C4 levels are low in all types of C1 inhibitor deficiency due to the instability of C1 (C1r, in particular) such that some activated C1 always circulates and depletes C4. In the hereditary disorder, formation of factor XIIf (factor XII fragment) during attacks of swelling causes C4 levels to drop toward zero, and C2 levels decline. A kinin-like molecule, once thought to be a cleavage product derived from C2 that contributes to the increased vascular permeability seen in hereditary angioedema (HAE), is now thought to be an artifact, i.e. no such molecule is demonstrable. The acquired C1 inhibitor deficiency is associated with clonal disorders of B cell hyperreactivity, including lymphoma and monoclonal gammopathy. Most cases have an IgG autoantibody to C1 inhibitor which inactivates it so that the presentation is strikingly similar to type I HAE. New therapies for types I and II HAE include C1 inhibitor replacement therapy, ecallantide, a kallikrein antagonist, and icatibant, a B2 receptor antagonist. A newly described type III HAE has normal C1 inhibitor, although it is thought to be mediated by bradykinin, as is an antihistamine-resistant subpopulation of

  13. A leitura mediada como estratégia de cuidado lúdico: contribuição ao campo da enfermagem fundamental La lectura mediada como atención lúdica: contribución al campo de la enfermería básica The mediate reading as a ludic care strategy: Contribution to the basic nursing area

    Directory of Open Access Journals (Sweden)

    Lívia Rodrigues Mendes

    2009-09-01

    cuidados y atención se concretizan como los principios de la teoría del cuidado humano y, también, del Proyecto Humaniza SUS, cuyas estrategias de acoger al paciente están ganando cada dia más importancia.The purpose is the mediated reading to hospitalized child as "ludic" strategy. The objectives are: Identify the meanings of reading mediation actions attributed by the subjects; characterize their contributions to hospitalized children, and discuss the mediated reading as expressive / "ludic" strategy of basic care. It is a descriptive and qualitative study conducted with 10 hospitalized children and their 10 escorts; 07 reading mediators, and 10 nursing team's members. The benefits of reading were evidenced on children and their escort's well-being which promote the health team's work. For the professionals and mediators, the mediated reading is a humanization care strategy that reduce psychic surcharge and provides emotional comfort to the children, softening their suffering. It concluded that combining "ludism" and care is in line with the principles of the theory of human care and also the project called Humaniza SUS, whose host strategies of customer are valued.

  14. 15 CFR 923.54 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Mediation. 923.54 Section 923.54... Mediation. (a) Section 307(h) of the Act provides for mediation of serious disagreement between any Federal... cases, mediation by the Secretary, with the assistance of the Executive Office of the President, may...

  15. 34 CFR 110.32 - Mediation.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Mediation. 110.32 Section 110.32 Education Regulations..., Conciliation, and Enforcement Procedures § 110.32 Mediation. (a) ED promptly refers to the Federal Mediation and Conciliation Service or to the mediation agency designated by the Secretary of Health and...

  16. Neutrality in mediation: an ambiguous ethical value

    OpenAIRE

    Bailey, Paul

    2014-01-01

    Mediator neutrality would appear, by definition, to be a necessary and required ethical principle for all mediators to practice. But what is meant by neutrality in mediation? Is it practically possible to be completely neutral between parties in mediation while at the same time being fair to both of them? This paper attempts to answer these two questions.

  17. 45 CFR 1156.16 - Mediation.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Mediation. 1156.16 Section 1156.16 Public Welfare... Procedures § 1156.16 Mediation. (a) Referral of complaints for mediation. The Endowment will promptly refer all complaints to the agency designated by the Secretary of HHS to manage the mediation process...

  18. Mediation in Schools: Tapping the Potential

    Science.gov (United States)

    Hendry, Richard

    2010-01-01

    This article explores the developing role of mediation as a conflict resolution process in schools. It gives an accepted definition and clarifies the purposes of mediation, outlining the range of contexts in and beyond schools in which mediation is already offered as a formal intervention. The typical process of mediation itself is described. The…

  19. 14 CFR 1252.402 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Mediation. 1252.402 Section 1252.402... Procedures § 1252.402 Mediation. (a) Referral of complaints for mediation. NASA will refer to the Federal Mediation and Conciliation Service all complaints that: (1) Fall within the jurisdiction of the Act...

  20. 24 CFR 146.35 - Mediation.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Mediation. 146.35 Section 146.35... ASSISTANCE Investigation, Settlement, and Enforcement Procedures § 146.35 Mediation. (a) HUD shall refer to the Federal Mediation and Conciliation Service, a mediation agency designated by the Secretary...

  1. 45 CFR 91.43 - Mediation.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Mediation. 91.43 Section 91.43 Public Welfare... Enforcement Procedures § 91.43 Mediation. (a) HHS will promptly refer to a mediation agency designated by the... mediation process to the extent necessary to reach an agreement or make an informed judgment that...

  2. 7 CFR 780.9 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Mediation. 780.9 Section 780.9 Agriculture Regulations... PROGRAMS APPEAL REGULATIONS § 780.9 Mediation. (a) Any request for mediation must be submitted after... once: (1) If resolution of an adverse decision is not achieved in mediation, a participant may...

  3. 22 CFR 218.33 - Mediation.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Mediation. 218.33 Section 218.33 Foreign... § 218.33 Mediation. (a) Referral of complaints for mediation. The agency will refer to the Federal Mediation and Conciliation Service all complaints that: (1) fall within the jurisdiction of...

  4. 38 CFR 18.543 - Mediation.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Mediation. 18.543 Section... Enforcement Procedures § 18.543 Mediation. (a) Referral of complaints for mediation. VA will refer to the Federal Mediation and Conciliation Service all complaints that: (1) Fall within the jurisdiction of...

  5. 43 CFR 17.332 - Mediation.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Mediation. 17.332 Section 17.332 Public..., and Enforcement Procedures § 17.332 Mediation. (a) Referral of complaints for mediation. DOI will... participate in the mediation process to the extent necessary to reach an agreement or make an...

  6. 15 CFR 20.12 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Mediation. 20.12 Section 20.12... Procedures § 20.12 Mediation. (a) DOC will refer to a mediation service designated by the Secretary all... further processing. (b) Both the complainant and the recipient shall participate in the mediation...

  7. 15 CFR 930.111 - OCRM mediation.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false OCRM mediation. 930.111 Section 930... FEDERAL CONSISTENCY WITH APPROVED COASTAL MANAGEMENT PROGRAMS Secretarial Mediation § 930.111 OCRM mediation. The availability of mediation does not preclude use by the parties of alternative means...

  8. 10 CFR 1040.89-6 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... Enforcement Procedures § 1040.89-6 Mediation. (a) Referral of complaints for mediation. DOE will refer to the Federal Mediation and Conciliation Service, in accordance with 45 CFR 90.43(c)(3), all complaints that: (1... 10 Energy 4 2010-01-01 2010-01-01 false Mediation. 1040.89-6 Section 1040.89-6 Energy...

  9. 10 CFR 4.333 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Mediation. 4.333 Section 4.333 Energy NUCLEAR REGULATORY... Investigation, Conciliation, and Enforcement Procedures § 4.333 Mediation. (a) Referral of complaints for mediation. NRC will refer to a mediation agency designated by the Secretary of the Department of Health...

  10. 7 CFR 614.11 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Mediation. 614.11 Section 614.11 Agriculture... AGRICULTURE CONSERVATION OPERATIONS NRCS APPEAL PROCEDURES § 614.11 Mediation. (a) A participant who wishes to pursue mediation must file request for mediation under this part with the NRCS official designated in...

  11. Carbon mediated catalysis:A review on oxidative dehydrogenation

    Institute of Scientific and Technical Information of China (English)

    De Chen; Anders Holmen; Zhijun Sui; Xinggui Zhou

    2014-01-01

    Carbon mediated catalysis has gained an increasing attention in both areas of nanocatalysis and nanomaterials. The progress in carbon nanomaterials provides many new opportunities to manip-ulate the types and properties of active sites of catalysts through manipulating structures, function-alities and properties of carbon surfaces. The present review focuses on progresses in carbon medi-ated oxidative dehydrogenation reactions of ethylbenzene, propane, and butane. The state-of-the-art of the developments of carbon mediated catalysis is discussed in terms of fundamental studies on adsorption of oxygen and hydrocarbons, reaction mechanism as well as effects of carbon nano-material structures and surface functional groups on the catalytic performance. We highlight the importance and challenges in tuning of the electron density of carbon and oxygen on carbon surfac-es for improving selectivity in oxidative dehydrogenation reactions.

  12. Web Feature Service Semantic Mediation

    Science.gov (United States)

    Hobona, G.; Bermudez, L. E.; Brackin, R.; Percivall, G. S.

    2012-12-01

    Scientists from different organizations and disciplines need to work together to find the solutions to complex problems. Multi-disciplinary science typically involves users with specialized tools and their own preferred view of the data including unique characteristics of the user's information model and symbology. Even though organizations use web services to expose data, there are still semantic inconsistencies that need to be solved. Recent activities within the OGC Interoperability Program (IP) have helped advance semantic mediation solutions when using OGC services to help solve complex problems. The OGC standards development process is influenced by the feedback of activities within the Interoperability Program, which conducts international interoperability initiatives such as Testbeds, Pilot Projects, Interoperability Experiments, and Interoperability Support Services. These activities are designed to encourage rapid development, testing, validation, demonstration and adoption of open, consensus based standards and best practices. Two recent Testbeds, the OGC Web Services Phase 8 and Phase 9, have advanced the use of semantic mediation approaches to increase semantic interoperability among geospatial communities. The Cross-Community Interoperability (CCI) thread within these two testbeds, advanced semantic mediation approaches for data discovery, access and use of heterogeneous data models and heterogeneous metadata models. This presentation will provide an overview of the interoperability program, the CCI Thread and will explain the methodology to mediate heterogeneous GML Application Profiles served via WFS, including discovery of services via a catalog standard interface and mediating symbology applicable to each application profile.

  13. Gaugino-Assisted Anomaly Mediation

    International Nuclear Information System (INIS)

    We present a model of supersymmetry breaking mediated through a small extra dimension. Standard model matter multiplets and a supersymmetry-breaking (or ''hidden'') sector are confined to opposite four-dimensional boundaries while gauge multiplets live in the bulk. The hidden sector does not contain a singlet and the dominant contribution to gaugino masses is via anomaly-mediated supersymmetry breaking. Scalar masses get contributions from both anomaly mediation and a tiny hard breaking of supersymmetry by operators on the hidden-sector boundary. These operators contribute to scalar masses at one loop and in most of parameter space, their contribution dominates. Thus it is easy to make all squared scalar masses positive. As no additional fields or symmetries are required below the Planck scale, we consider this the simplest working model of anomaly mediation. The gaugino spectrum is left untouched and the phenomenology of the model is roughly similar to anomaly mediated supersymmetry breaking with a universal scalar mass added. We identify the main differences in the spectrum between this model and other approaches. We also discuss mechanisms for generating the μ term and constraints on additional bulk fields. (author)

  14. Gaugino-assisted anomaly mediation

    International Nuclear Information System (INIS)

    I present a model of supersymmetry breaking mediated through a small extra dimension. Standard model matter multiplets and a supersymmetry-breaking (or 'hidden') sector are confined to opposite four-dimensional boundaries while gauge multiplets live in the bulk. The hidden sector does not contain a singlet and the dominant contribution to gaugino masses is via anomaly-mediated supersymmetry breaking. Scalar masses get contributions from both anomaly mediation and a tiny hard breaking of supersymmetry by operators on the hidden-sector boundary. These operators contribute to scalar masses at one loop and in most of parameter space, their contribution dominates. Thus it is easy to make all squared scalar masses positive. As no additional fields or symmetries are required below the Planck scale, this is among the simplest working models of anomaly mediation. The gaugino spectrum is left untouched and the phenomenology of the model is roughly similar to anomaly mediated supersymmetry breaking with a universal scalar mass added. Finally, the main differences in the spectrum between this model and other approaches are identified. This talk is based on work [1] done in collaboration with David E. Kaplan

  15. A Graphical Representation of the Mediated Effect

    OpenAIRE

    Fritz, Matthew S.; David P. MacKinnon

    2008-01-01

    Mediation analysis is widely used in the social sciences. Despite the popularity of mediation models, few researchers have used graphical methods, other than structural path diagrams, to represent their models. Plots of the mediated effect can help a researcher better understand the results of the analysis and convey these results to others. This article presents a method for creating and interpreting plots of the mediated effect for a variety of mediation models, including models with a dich...

  16. MEDIATION IN THE WORK OF HIGHER SCHOOL TEACHER

    Directory of Open Access Journals (Sweden)

    Yekaterina V. Ryabinina

    2015-03-01

    Full Text Available The purpose of this paper is to study modern conflictological situation in Russian society, which requires the widespread introduction of new technologies for the management of conflicts in the educational process and re-thinking of the teacher’s role as a mediator to optimize the relationship process among students. Results. The author describes the stages of mediation and the specific work of the teacher-mediator in the educational organization and the requirements for their qualifications, demonstrates the types of activities of conflict resolution and their impact on the participants of conflict interaction. Particular attention is considered to the basic principles of mediation in the educational system. Scientific novelty. The author singles out the problems of mediation in the work of higher school teachers. The teacher defending the rights of students tries to resolve any disputes and conflicts with the interests of the disputing parties and social justice. Mediation as a form of alternative dispute resolution is becoming an integral part of the legal culture of our society. The article points to the need to enhance the conflict competence of teachers of higher schools. Practical significance. The research findings can be useful for psychologists, managers in the education system and teachers of higher education; conclusions proposed in the article can find practical implementation in teaching the course «Conflict Management». Presented theoretical material can be used for the formation and development of a mediation service in high school, should be the subject of further research in this area to find out alternative methods of dispute resolution in educational process. 

  17. Gauge Mediated Mini-Split

    CERN Document Server

    Cohen, Timothy; Knapen, Simon

    2015-01-01

    We propose a simple model of split supersymmetry from gauge mediation. This model features gauginos that are parametrically a loop factor lighter than scalars, accommodates a Higgs boson mass of 125 GeV, and incorporates a simple solution to the $\\mu-b_\\mu$ problem. The gaugino mass suppression can be understood as resulting from collective symmetry breaking. Imposing collider bounds on $\\mu$ and requiring viable electroweak symmetry breaking implies small $a$-terms and small $\\tan \\beta$ -- the stop mass ranges from $10^5$ to $10^8 \\mbox{ GeV}$. In contrast with models with anomaly + gravity mediation (which also predict a one-loop loop suppression for gaugino masses), our gauge mediated scenario predicts aligned squark masses and a gravitino LSP. Gluinos, electroweakinos and Higgsinos can be accessible at the LHC and/or future colliders for a wide region of the allowed parameter space.

  18. Mediated Modeling in Science Education

    Science.gov (United States)

    Halloun, Ibrahim A.

    2007-08-01

    Following two decades of corroboration, modeling theory is presented as a pedagogical theory that promotes mediated experiential learning of model-laden theory and inquiry in science education. Students develop experiential knowledge about physical realities through interplay between their own ideas about the physical world and particular patterns in this world. Under teacher mediation, they represent each pattern with a particular model that they develop through a five-phase learning cycle, following particular modeling schemata of well-defined dimensions and rules of engagement. Significantly greater student achievement has been increasingly demonstrated under mediated modeling than under conventional instruction of lecture and demonstration, especially in secondary school and university physics courses. The improved achievement is reflected in more meaningful understanding of course materials, better learning styles, higher success rates, lower attrition rates and narrower gaps between students of different backgrounds.

  19. Mediation in Legal English Teaching

    Directory of Open Access Journals (Sweden)

    Chovancová Barbora

    2016-06-01

    Full Text Available Mediation is a language activity that has been unjustly neglected when preparing law students for their future professional careers. When trained in a professional context, students need to develop and improve complex communicative skills. These include not only the traditional language skills such as reading, writing, listening and speaking, but also more advanced skills such as summarizing, providing definitions, changing registers etc. All these are involved in the students’ acquisition of ‘soft skills’ that are particularly important for students of law since much of their future work involves interpersonal lawyer-client interaction. This article argues that mediation is a crucial (though previously underestimated skill and that law-oriented ESP instruction should provide training aimed at developing this skill. Showing a practical application of this approach, the paper demonstrates that mediation can be successfully integrated in the legal English syllabus and make the learning of legal English more effective.

  20. Family education and television mediation

    Directory of Open Access Journals (Sweden)

    Paz CÁNOVAS LEONHARDT

    2010-07-01

    Full Text Available This article try to deal with the complex influence of television viewing in the process of socialization of children and adolescents, focusing our attention on the importance of the family as the mediator-educator agency of particular relevance. Once analyzed the basic theoretical assumptions, we deepened in reality under study by providing data about how the studied population lives television and what extent parental mediation influences and affects the process. The article concludes with some reflections and pedagogical suggestions which trying to help to the optimization of the educational reality.

  1. Playful mediation and virtual sociality

    Directory of Open Access Journals (Sweden)

    Sihem NAJJAR

    2010-01-01

    Full Text Available As a space of sociability, virtual games, especially online role playing games, allow us to capture the interest of the playfulness in social life, but they are means by which users are able to experiment their relationship to others. The virtual games as a mediation device, constitute a "pretext" to forge friendships, develop love relationships, improve language skills, discover other cultures, etc. Based on a sociological survey of Tunisian Internet users (both sexes fans of virtual games we try to show how playful mediation is producing a multifaceted virtual sociality inherent in our contemporary societies.

  2. Sommerfeld Enhancement from Multiple Mediators

    OpenAIRE

    McDonald, Kristian L.

    2012-01-01

    We study the Sommerfeld enhancement experienced by a scattering object that couples to a tower of mediators. This can occur in, e.g., models of secluded dark matter when the mediator scale is generated naturally by hidden-sector confinement. Specializing to the case of a confining CFT, we show that off-resonant values of the enhancement can be increased by ~ 20% for cases of interest when (i) the (strongly-coupled) CFT admits a weakly-coupled dual description and (ii) the conformal symmetry h...

  3. Secure mediated certificateless signature scheme

    Institute of Scientific and Technical Information of China (English)

    YANG Chen; MA Wen-ping; WANG Xin-mei

    2007-01-01

    Ju et al proposed a certificateless signature scheme with instantaneous revocation by introducing security mediator (SEM) mechanism. This article presents a detailed cryptoanalysis of this scheme and shows that, in their proposed scheme, once a valid signature has been produced, the signer can recover his private key information and the instantaneous revocation property will be damaged. Furthermore, an improved mediated signature scheme, which can eliminate these disadvantages, is proposed, and security proof of the improved scheme under elliptic curve factorization problem (ECFP) assumption and bilinear computational diffie-hellman problem (BCDH) assumption is also proposed.

  4. Surfactant-Mediated Growth Revisited

    International Nuclear Information System (INIS)

    The x-ray structure analysis of the oxygen-surfactant-mediated growth of Ni on Cu(001) identifies up to 0.15 monolayers of oxygen in subsurface octahedral sites. This questions the validity of the general view that surfactant oxygen floats on top of the growing Ni film. Rather, the surfactant action is ascribed to an oxygen-enriched zone extending over the two topmost layers. Surface stress measurements support this finding. Our results have important implications for the microscopic understanding of surfactant-mediated growth and the change of the magnetic anisotropy of the Ni films

  5. MEDIATING DIASPORA, IDENTITY AND ETHNICITY: AN INTERVIEW WITH MYRIA GEORGIOU

    OpenAIRE

    Sandy Watson

    2011-01-01

    Myria Georgiou is noted for her influential and longstanding theorisation on diaspora, media and identity, including the first mapping of diasporic media in the European Union, together with Roger Silverstone. She has also authored a significant number of books covering areas such as transnationalism and diasporic media (2007a; 2007b; 2006), national identity and ethnicity (2008b; 2006), media and urban life (2008a); and mediations of ethnicity and race (2010; 2009).

  6. Uranium-mediated oxidative addition and reductive elimination

    OpenAIRE

    Lu, Erli; Liddle, Stephen T

    2015-01-01

    Oxidative addition, and its reverse reaction reductive elimination, constitute two key reactions that underpin organometallic chemistry and catalysis. Although these reactions have been known for decades in main group and transition metal systems, they are exceptionally rare or unknown for the f-block. However, in recent years much progress has been made. In this Perspective article, advances in uranium-mediated oxidative addition/reductive elimination, since the point that this research area...

  7. Membrane tension and peripheral protein density mediate membrane shape transitions

    OpenAIRE

    Shi, Zheng; Baumgart, Tobias

    2015-01-01

    Endocytosis is a ubiquitous eukaryotic membrane budding, vesiculation, and internalization process fulfilling numerous roles including compensation of membrane area increase after bursts of exocytosis. The mechanism of the coupling between these two processes to enable homeostasis is not well understood. Recently, an ultrafast endocytosis (UFE) pathway was revealed with a speed significantly exceeding classical clathrin-mediated endocytosis (CME). Membrane tension reduction is a potential mec...

  8. Eicosanoids mediate insect hemocyte migration

    Science.gov (United States)

    Hemocyte chemotaxis toward infection and wound sites is an essential component of insect defense reactions, although the biochemical signal mechanisms responsible for mediating chemotaxis in insect cells are not well understood. Here we report on the outcomes of experiments designed to test the hyp...

  9. Mediation analysis with principal stratification.

    Science.gov (United States)

    Gallop, Robert; Small, Dylan S; Lin, Julia Y; Elliott, Michael R; Joffe, Marshall; Ten Have, Thomas R

    2009-03-30

    In assessing the mechanism of treatment efficacy in randomized clinical trials, investigators often perform mediation analyses by analyzing if the significant intent-to-treat treatment effect on outcome occurs through or around a third intermediate or mediating variable: indirect and direct effects, respectively. Standard mediation analyses assume sequential ignorability, i.e. conditional on covariates the intermediate or mediating factor is randomly assigned, as is the treatment in a randomized clinical trial. This research focuses on the application of the principal stratification (PS) approach for estimating the direct effect of a randomized treatment but without the standard sequential ignorability assumption. This approach is used to estimate the direct effect of treatment as a difference between expectations of potential outcomes within latent subgroups of participants for whom the intermediate variable behavior would be constant, regardless of the randomized treatment assignment. Using a Bayesian estimation procedure, we also assess the sensitivity of results based on the PS approach to heterogeneity of the variances among these principal strata. We assess this approach with simulations and apply it to two psychiatric examples. Both examples and the simulations indicated robustness of our findings to the homogeneous variance assumption. However, simulations showed that the magnitude of treatment effects derived under the PS approach were sensitive to model mis-specification. PMID:19184975

  10. Should Lawyers Act as Mediators?

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    On September 1, the Henan Provincial Department of Justice and the Henan Higher People’s Court jointly issued a document. It suggests lawyers do as much as possible to mediate between litigants involved in lawsuits of civil disputes and misdemeanor lawsuits, in order to help them

  11. Anomaly mediation in superstring theory

    Energy Technology Data Exchange (ETDEWEB)

    Conlon, Joseph P. [Rudolf Peierls Center for Theoretical Physics, Oxford (United Kingdom); Balliol College, Oxford (United Kingdom); Goodsell, Mark [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Palti, Eran [Centre de Physique Theoretique, Ecole Polytechnique, CNRS, Palaiseau (France)

    2010-08-15

    We study anomaly mediated supersymmetry breaking in type IIB string theory and use our results to test the supergravity formula for anomaly mediated gaugino masses. We compute 1-loop gaugino masses for models of D3-branes on orbifold singularities with 3-form fluxes by calculating the annulus correlator of 3-form flux and two gauginos in the zero momentum limit. Consistent with supergravity expectations we find both anomalous and running contributions to 1-loop gaugino masses. For background Neveu-Schwarz H-flux we find an exact match with the supergravity formula. For Ramond-Ramond flux there is an off-shell ambiguity that precludes a full matching. The anomaly mediated gaugino masses, while determined by the infrared spectrum, arise from an explicit sum over UV open string winding modes. We also calculate brane-to-brane tree-level gravity mediated gaugino masses and show that there are two contributions coming from the dilaton and from the twisted modes, which are suppressed by the full T{sup 6} volume and the untwisted T{sup 2} volume respectively. (orig.)

  12. Anomaly mediation in superstring theory

    International Nuclear Information System (INIS)

    We study anomaly mediated supersymmetry breaking in type IIB string theory and use our results to test the supergravity formula for anomaly mediated gaugino masses. We compute 1-loop gaugino masses for models of D3-branes on orbifold singularities with 3-form fluxes by calculating the annulus correlator of 3-form flux and two gauginos in the zero momentum limit. Consistent with supergravity expectations we find both anomalous and running contributions to 1-loop gaugino masses. For background Neveu-Schwarz H-flux we find an exact match with the supergravity formula. For Ramond-Ramond flux there is an off-shell ambiguity that precludes a full matching. The anomaly mediated gaugino masses, while determined by the infrared spectrum, arise from an explicit sum over UV open string winding modes. We also calculate brane-to-brane tree-level gravity mediated gaugino masses and show that there are two contributions coming from the dilaton and from the twisted modes, which are suppressed by the full T6 volume and the untwisted T2 volume respectively. (orig.)

  13. Introducing the Civil Wars mediation (CWM) dataset

    OpenAIRE

    2011-01-01

    Mediation is one of the few mechanisms the international community can deploy that will affect civil wars. This article introduces the dataset on mediation in civil wars – termed the Civil War Mediation (CWM) dataset. This is the first dataset to focus solely on civil war mediation. These data contribute to the present state of quantitative research on mediation in three important respects: the data are collected for the period of 1946–2004, are organized by mediation cases and by civil war e...

  14. BOEM Wind Planning Areas

    Data.gov (United States)

    Bureau of Ocean Energy Management, Department of the Interior — This data set represents the most recent changes for the Wind Development Planning Areas in the Atlantic. Wind Planning Areas in this dataset represent up to six...

  15. Euro area business cycles

    OpenAIRE

    Atilim Seymen

    2012-01-01

    The role of global, euro area and country-specific shocks in business cycle dynamics of six euro area member countries is assessed with the aid of SVAR models. Output fluctuations are driven by global shocks to a large extent in the euro area, and no Europeanisation of business cycles due to, for example the European Monetary Union, could be established. Business cycle heterogeneity is driven mainly by (asymmetric) country-specific shocks in the euro area and not by heterogeneous responses to...

  16. [Familiy mediation within the counselling system].

    Science.gov (United States)

    Bastine, Reiner; Römer-Wolf, Birgit; Decker, Frauke; Haid-Loh, Achim; Mayer, Stefan; Normann, Katrin

    2006-01-01

    Family mediation has been established as a method of resolving family conflicts within the counselling system. Unfortunately there existed only rare information about the real presence and efficacy of family mediation services within this system. 726 counselling centres from all over the country participated at the present study, which was outlined to evaluate their supply of family mediation and the use of it. The results show that nearly one third of the centres are offering family mediation as a regular service to their clients, and that mediative skills are quite frequently used by the counselling professionals. Centres, which offer a regular service of mediation, have an obviously higher percentage of honorary staff, indicating that this service might have a more fragile status. Each centre, which conducted mediation, had an average mediation caseload of 32 in 2003, which means a percentage of 7 percent of all counselling cases treated in this year. These mediations needed an average treatment of 7 hours. Most frequent cases in mediation are separated married or separated non-married parents with 2 children. In most cases, family mediation was used to regulate conflicts in separation, divorce or post divorce, mainly concerned with issues of child custody. In contrast to the researchers' expectations, children were introduced at the mediation process only rarely. The need for mediation in the local population was rated much higher than the factual demand for and the factual supply of mediation. Based on the outcomes of the study, some recommendations are made: for the improvement of the supply of family mediation, for the expansion of the issues to which mediation is offered, and for strengthening the approaches to include children into the mediation process. PMID:17152893

  17. Selected areas in cryptography

    CERN Document Server

    Oorschot, Paul

    1997-01-01

    Selected Areas in Cryptography brings together in one place important contributions and up-to-date research results in this fast moving area. Selected Areas in Cryptography serves as an excellent reference, providing insight into some of the most challenging research issues in the field.

  18. Women's Facial Redness Increases Their Perceived Attractiveness: Mediation Through Perceived Healthiness.

    Science.gov (United States)

    Pazda, Adam D; Thorstenson, Christopher A; Elliot, Andrew J; Perrett, David I

    2016-07-01

    In the present research, we investigated whether the red-attraction relation that has been observed for men viewing women may also be observed with regard to women's facial redness. We manipulated facial redness by slightly increasing or decreasing the redness on the faces of baseline pictures of target women, and then had men judge the attractiveness of the women. We also examined healthiness perceptions as a mediator of the redness-attraction relation, along with several other candidate mediator variables. A series of experiments showed that increased redness led to increased ratings of attractiveness, and decreased redness led to decreased ratings of attractiveness. Perceived healthiness was documented as a mediator of the influence of female facial redness on male perceptions of attractiveness, and this mediation was independent of other candidate mediator variables. The findings highlight the importance of attending to facial coloration as an attraction-relevant cue and point to interesting areas for subsequent research. PMID:26908567

  19. Platelets stimulate fibroblast-mediated contraction of collagen gels

    Directory of Open Access Journals (Sweden)

    Lundahl Joachim

    2003-10-01

    Full Text Available Abstract Background Platelets are thought to play a role in a variety of inflammatory conditions in the lung, some of which may lead to fibrosis. In the current study we tested the hypothesis that whole platelets and platelet lysate can mediate remodelling of extracellular matrix in vitro by affecting fibroblast-mediated contraction of a collagen gel. We also sought to determine to what extent platelet-derived growth factor (PDGF and transforming growth factor-β (TGF-β contribute to this effect. Methods Washed platelets, isolated from healthy blood donors, and platelet lysate (freezing and thawing, were cast together with human lung fibroblasts in three-dimensional collagen gels. The gels were then released and cultured for four days. PDGF and TGF-β1 concentrations were measured in culture supernatants by ELISA. Results Both platelets and platelet lysate augmented fibroblast-mediated gel contraction in a time and concentration dependent manner (19.9% ± 0.1 (mean ± SEM of initial area vs. 48.0% ± 0.4 at 48 hours; P 1 and PDGF-AA/AB were released in co-culture. PDGF-AA/AB had a maximum release at 24 hours whereas TGF-β1 release increased with longer culture periods. Neutralising antibodies to these mediators partially inhibited platelet-induced gel contraction. Conclusion We conclude that platelets may promote remodelling of extracellular matrix in vitro and that PDGF and TGF-β partially mediate this effect, also indicating a role for other mediators. The findings may be an important mechanism in regulating repair processes after injury.

  20. LEGAL CULTURES AND MEDIATION. INTERACTIONS AND EVOLUTIONS

    Directory of Open Access Journals (Sweden)

    Claudiu Ramon D. BUTCULESCU

    2014-05-01

    Full Text Available Mediation, as an alternative dispute resolution method, is closely connected with the system of legal cultures. Mediation is an important link between legal culture and the judicial system. Mediation also acts as an interface between internal legal culture and external legal culture. This paper addresses the issues regarding the links and interactions between mediation and legal cultures, as well as the effects that arise from these interactions.

  1. Possibility of mediation usage in specail schools

    OpenAIRE

    Šumak, Alja

    2013-01-01

    The thesis deals with the conflicts resolution as it is done in primary schools. Detailed attention is given to mediation as a means of conflict resolution, with school and peer mediation as its subtypes. The advantages and dilemmas of using mediation are listed. The thesis contains information about developmental-psychological characteristics of the disputants and the mediators as well as the course of the psychological development of children in certain fields. The aim of the thesis is to...

  2. Aspects of non-minimal gauge mediation

    OpenAIRE

    Shirai, Satoshi; Yamazaki, Masahito; Yonekura, Kazuya

    2010-01-01

    A large class of non-minimal gauge mediation models, such as (semi-)direct gauge mediation, predict a hierarchy between the masses of the supersymmetric standard model gauginos and those of scalar particles. We perform a comprehensive study of these non-minimal gauge mediation models, including mass calculations in semi-direct gauge mediation, to illustrate these features, and discuss the phenomenology of the models. We point out that the cosmological gravitino problem places stringent constr...

  3. Mediation Analysis in Psychosomatic Medicine Research

    OpenAIRE

    Lockhart, Ginger; MacKinnon, David P.; Ohlrich, Vanessa

    2010-01-01

    This article presents an overview of statistical mediation analysis and its application to psychosomatic medicine research. The article begins with a description of the major approaches to mediation analysis and an evaluation of the strengths and limits of each. Emphasis is placed on longitudinal mediation models, and an application using latent growth modeling is presented. The article concludes with a description of recent developments in mediation analysis and suggestions for the use of me...

  4. The law applicable to International Mediation Contracts

    OpenAIRE

    Orejudo Prieto de los Mozos, Patricia

    2011-01-01

    Mediation entails the provision of the services of a professional, the mediator, who holds a legal relationship with the disputants: the mediation contract. Where there are transnational elements in the mediation process, the contract is of an international character. In such situation, the Laws of the diverse States involved could claim to be applicable to the same contract. The determination of the (only) Law applicable is of upmost interest in spite of the high degree of standardization of...

  5. Neural circuits mediating olfactory-driven behavior in fish

    Directory of Open Access Journals (Sweden)

    Florence Kermen

    2013-04-01

    Full Text Available The fish olfactory system processes odor signals and mediates behaviors that are crucial for survival such as foraging, courtship and alarm response. Although the upstream olfactory brain areas (olfactory epithelium and olfactory bulb are well studied, less is known about their target brain areas and the role they play in generating odor-driven behaviors. Here we review a broad range of literature on the anatomy, physiology and behavioral output of the olfactory system and its target areas in a wide range of teleost fish. Additionally, we discuss how applying recent technological advancements to the zebrafish (Danio rerio could help in understanding the function of these target areas. We hope to provide a framework for elucidating the neural circuit computations underlying the odor-driven behaviors in this small, transparent and genetically amenable vertebrate.

  6. Axino dark matter in mirage mediation

    International Nuclear Information System (INIS)

    The mirage mediation of supersymmetry breaking is a phenomenologically quite interesting possibility, however, it suffers from two major problems: the moduli-induced gravitino problem and the μ-Bμ problem. In this paper, we propose that the axionic extension of mirage mediation, axionic mirage mediation can solve both problems simultaneously. We address the cosmological consequences of the scenario extensively.

  7. Mediatized Extreme Right Activism and Discourse

    DEFF Research Database (Denmark)

    Peters, Rikke Alberg

    2015-01-01

    and mediatized activism. In order to analyse of the protest form, the visual aesthetics and the discourse of ‘The Immortals’, the paper mobilises two concepts from media and communication studies: mediation and mediatization. It will be argued that that the current transformation of the extreme right: that is...

  8. 13 CFR 117.12 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Mediation. 117.12 Section 117.12... Mediation. (a) SBA shall, after ensuring that the complaint falls within the coverage of this Act and all... clearly within an exception, promptly refer the complaint to the Federal Mediation and...

  9. 7 CFR 900.109 - Mediation agreement.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Mediation agreement. 900.109 Section 900.109 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... Mediation agreement. An agreement arrived at by mediation shall not become effective until approved by...

  10. 34 CFR 303.419 - Mediation.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Mediation. 303.419 Section 303.419 Education... DISABILITIES Procedural Safeguards Mediation and Due Process Procedures for Parents and Children § 303.419 Mediation. (a) General. Each State shall ensure that procedures are established and implemented to...

  11. 45 CFR 617.10 - Mediation.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Mediation. 617.10 Section 617.10 Public Welfare... OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM NSF § 617.10 Mediation. (a) NSF will refer to the Federal Mediation and Conciliation Service all complaints that fall...

  12. On the Spectrum of Direct Gaugino Mediation

    OpenAIRE

    Auzzi, Roberto; Giveon, Amit; Gudnason, Sven Bjarke; Shacham, Tomer

    2011-01-01

    In direct gauge mediation, the gaugino masses are anomalously small, giving rise to a split SUSY spectrum. Here we investigate the superpartner spectrum in a minimal version of "direct gaugino mediation." We find that the sfermion masses are comparable to those of the gauginos - even in the hybrid gaugino-gauge mediation regime - if the messenger scale is sufficiently small.

  13. 34 CFR 300.506 - Mediation.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Mediation. 300.506 Section 300.506 Education... DISABILITIES Procedural Safeguards Due Process Procedures for Parents and Children § 300.506 Mediation. (a... due process complaint, to resolve disputes through a mediation process. (b) Requirements....

  14. 7 CFR 205.663 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Mediation. 205.663 Section 205.663 Agriculture... PROVISIONS NATIONAL ORGANIC PROGRAM Administrative Compliance § 205.663 Mediation. Any dispute with respect... acceptance by the certifying agent. Mediation shall be requested in writing to the applicable...

  15. Single-Level and Multilevel Mediation Analysis

    Science.gov (United States)

    Tofighi, Davood; Thoemmes, Felix

    2014-01-01

    Mediation analysis is a statistical approach used to examine how the effect of an independent variable on an outcome is transmitted through an intervening variable (mediator). In this article, we provide a gentle introduction to single-level and multilevel mediation analyses. Using single-level data, we demonstrate an application of structural…

  16. 41 CFR 101-8.717 - Mediation.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Mediation. 101-8.717... FINANCIAL ASSISTANCE 8.7-Discrimination Prohibited on the Basis of Age § 101-8.717 Mediation. (a) GSA promptly refers to the mediation agency designated by the Secretary, HHS, all sufficient complaints...

  17. Methods for Mediation Analysis with Missing Data

    Science.gov (United States)

    Zhang, Zhiyong; Wang, Lijuan

    2013-01-01

    Despite wide applications of both mediation models and missing data techniques, formal discussion of mediation analysis with missing data is still rare. We introduce and compare four approaches to dealing with missing data in mediation analysis including list wise deletion, pairwise deletion, multiple imputation (MI), and a two-stage maximum…

  18. 7 CFR 400.94 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Mediation. 400.94 Section 400.94 Agriculture... AGRICULTURE GENERAL ADMINISTRATIVE REGULATIONS Appeal Procedure § 400.94 Mediation. For adverse decisions only: (a) Appellants have the right to seek mediation or other forms of alternative dispute resolution...

  19. The communicative figurations of mediatized worlds: mediatization research in times of the “mediation of everything”

    Directory of Open Access Journals (Sweden)

    Andreas Hepp

    2014-06-01

    Full Text Available When various media in their entirety mark how we articulate our social worlds, we need an approach of mediatization research that reflects this transmediality. To develop such an approach, the article discusses the institutionalist and social-constructivist traditions of mediatization research. Both concur that mediatization is a concept to capture the interrelation between the change of media and communication, and the change of culture and society. Such a conceptual reflection offers the chance to view the mediatization as the change of transmedial communicative figurations. Based on this theoretical foundation, the article reflects a twofold operationalization, i.e. as diachronous and synchronous mediatization research.

  20. Carbon monoxide mediates vasoactive intestinal polypeptide-associated nonadrenergic/noncholinergic neurotransmission

    OpenAIRE

    Watkins, Crystal C.; Boehning, Darren; Kaplin, Adam I.; Rao, Mahil; Ferris, Christopher D.; Snyder, Solomon H.

    2004-01-01

    Carbon monoxide (CO) synthesized by heme oxygenase 2 (HO2) and nitric oxide (NO) produced by neuronal NO synthase (nNOS) mediate nonadrenergic/noncholinergic (NANC) intestinal relaxation. In many areas of the gastrointestinal tract, NO and CO function as coneurotransmitters. In the internal anal sphincter (IAS), NANC relaxation is mediated primarily by CO. Vasoactive intestinal polypeptide (VIP) has also been shown to participate in NANC relaxation throughout the intestine, including the IAS....

  1. Investigation of SNARE-Mediated Membrane Fusion Mechanism Using Atomic Force Microscopy

    OpenAIRE

    Abdulreda, Midhat H.; Moy, Vincent T.

    2009-01-01

    Membrane fusion is driven by specialized proteins that reduce the free energy penalty for the fusion process. In neurons and secretory cells, soluble N-ethylmaleimide-sensitive factor-attachment protein (SNAP) receptors (SNAREs) mediate vesicle fusion with the plasma membrane during vesicular content release. Although, SNAREs have been widely accepted as the minimal machinery for membrane fusion, the specific mechanism for SNARE-mediated membrane fusion remains an active area of research. Her...

  2. Introduction: Mediating and Remediating Death

    DEFF Research Database (Denmark)

    Christensen, Dorthe Refslund; Sandvik, Kjetil

    2014-01-01

    In this second volume we explore how people, groups and institutions deal with death through processes of mediation (the presentation of something through media), remediation (the representation of one medium in another, see below) and mediatization (the process through which core elements of a...... social or cultural activity assume media form, see below). The volume presents a wide variety of ethnographies of death from Norway, Finland, Sweden, the US, Papua New Guinea, Bosnia and Hercegovina, Libya, Tibet, Uganda and Denmark as well as a number of online sites and social media material. These are...... analyzed through a vast number of theoretical and analytical perspectives in order to investigate how very diverse practices surrounding death and dying - mourning and commemoration, ritualization, politicization, re-enactment, traditionalization, activism or documentarism: private or public, offline or...

  3. Elastocapillary-mediated interfacial assembly

    Science.gov (United States)

    Evans, Arthur

    2015-11-01

    Particles confined to an interface are present in a large number of industrial applications and ubiquitous in cellular biophysics. Interactions mediated by the interface, such as capillary effects in the presence of surface tension, give rise to rafts and aggregates whose structure is ultimately determined by geometric characteristics of these adsorbed particles. A common strategy for assembling interfacial structures relies on exploiting these interactions by tuning particle anisotropy, either by constructing rigid particles with heterogeneous wetting properties or fabricating particles that have a naturally anisotropic shape. Less explored, however, is the scenario where the interface causes the particles to deform. In this talk I will discuss the implications for interfacial assembly using elastocapillary-mediated interactions. The competition between surface energy and elasticity can wrinkle and buckle adsorbed soft particles, leading to complicated (but programmable) aggregates.

  4. Sequestered gravity in gauge mediation

    Science.gov (United States)

    Antoniadis, Ignatios; Benakli, Karim; Quiros, Mariano

    2016-07-01

    We present a novel mechanism of supersymmetry breaking embeddable in string theory and simultaneously sharing the main advantages of (sequestered) gravity and gauge mediation. It is driven by a Scherk-Schwarz deformation along a compact extra dimension, transverse to a brane stack supporting the supersymmetric extension of the Standard Model. This fixes the magnitude of the gravitino mass, together with that of the gauginos of a bulk gauge group, at a scale as high as 10^{10} GeV. Supersymmetry breaking is mediated to the observable sector dominantly by gauge interactions using massive messengers transforming non-trivially under the bulk and Standard Model gauge groups and leading to a neutralino LSP as dark matter candidate. The Higgsino mass μ and soft Higgs-bilinear B_μ term could be generated at the same order of magnitude as the other soft terms by effective supergravity couplings as in the Giudice-Masiero mechanism.

  5. Mediational Competencies for Online Education

    Directory of Open Access Journals (Sweden)

    María Elena Chan Núñez

    2005-11-01

    Full Text Available Addressed in the article is a position taken within and in favor of education and virtuality, considering the importance of training constructors of the digital environment. The competencies needed by actors of educational processes, the same which are necessary for their construction, are conceptualized as mediational. Because these are not usually the competencies most visibly when teachers and students are trained for online education, we found it of interest to present part of a research project on this type of competencies. The work starts out from an axiological position on virtual education, the recognition of the way the technologies model educational interactions on line. It follows with the notion of mediation and meditational competency, and comes to a design model that would consider these competencies in the development of learning environments. The article closes with reflections about the interdisciplinary integration necessary for a technological and educational development based on a communicative paradigm.

  6. Mediational Competencies for Online Education

    OpenAIRE

    María Elena Chan Núñez

    2005-01-01

    Addressed in the article is a position taken within and in favor of education and virtuality, considering the importance of training constructors of the digital environment. The competencies needed by actors of educational processes, the same which are necessary for their construction, are conceptualized as mediational. Because these are not usually the competencies most visibly when teachers and students are trained for online education, we found it of interest to present part of a research ...

  7. Palladium-mediated intracellular chemistry

    OpenAIRE

    Rahimi M. Yusop; Unciti-Broceta, Asier; Johansson, Emma M. V.; Rosario M. Sanchez-Martin; Bradley, Mark

    2011-01-01

    Many important intracellular biochemical reactions are modulated by transition metals, typically in the form of metalloproteins. The ability to carry out selective transformations inside a cell would allow researchers to manipulate or interrogate innumerable biological processes. Here, we show that palladium nanoparticles trapped within polystyrene microspheres can enter cells and mediate a variety of Pd-0-catalysed reactions, such as allylcarbamate cleavage and Suzuki-Miyaura cross-coupling....

  8. Notch-Mediated Cell Adhesion

    OpenAIRE

    Akihiko Murata; Shin-Ichi Hayashi

    2016-01-01

    Notch family members are generally recognized as signaling molecules that control various cellular responses in metazoan organisms. Early fly studies and our mammalian studies demonstrated that Notch family members are also cell adhesion molecules; however, information on the physiological roles of this function and its origin is limited. In this review, we discuss the potential present and ancestral roles of Notch-mediated cell adhesion in order to explore its origin and the initial roles of...

  9. Direct mediation, duality and unification

    International Nuclear Information System (INIS)

    It is well-known that in scenarios with direct gauge mediation of supersymmetry breaking the messenger fields significantly affect the running of Standard Model couplings and introduce Landau poles which are difficult to avoid. Among other things, this appears to remove any possibility of a meaningful unification prediction and is often viewed as a strong argument against direct mediation. We propose two ways that Seiberg duality can circumvent this problem. In the first, which we call 'deflected-unification', the SUSY-breaking hidden sector is a magnetic theory which undergoes a Seiberg duality to an electric phase. Importantly, the electric version has fewer fundamental degrees of freedom coupled to the MSSM compared to the magnetic formulation. This changes the β-functions of the MSSM gauge couplings so as to push their Landau poles above the unification scale. We show that this scenario is realised for recently suggested models of gauge mediation based on a metastable SCQD-type hidden sector directly coupled to MSSM. The second possibility for avoiding Landau poles, which we call 'dual-unification', begins with the observation that, if the mediating fields fall into complete SU(5) multiplets, then the MSSM+messengers exhibits a fake unification at unphysical values of the gauge couplings. We show that, in known examples of electric/magnetic duals, such a fake unification in the magnetic theory reflects a real unification in the electric theory. We therefore propose that the Standard Model could itself be a magnetic dual of some unknown electric theory in which the true unification takes place. This scenario maintains the unification prediction (and unification scale) even in the presence of Landau poles in the magnetic theory below the GUT scale. We further note that this dual realization of grand unification can explain why Nature appears to unify, but the proton does not decay.

  10. Gauge mediation in metastable vacua

    International Nuclear Information System (INIS)

    Until recently, dynamical supersymmetry breaking seemed an exceptional phenomenon, involving chiral gauge theories with a special structure. Recently it has become clear that requiring only metastable states with broken supersymmetry leads to a far broader class of theories. In this paper, we extend these constructions still further, finding new classes which, unlike earlier theories, do not have unbroken, approximate R symmetries. This allows construction of new models with low energy gauge mediation

  11. Dynamin-mediated membrane fission

    OpenAIRE

    Morlot, Sandrine

    2012-01-01

    Membrane fission is required for vesicular traffic between intracellular compartments. Dynamin is a GTPase implicated in vesicle scission during Clathrin-mediated endocytosis. It polymerizes into a helix at the neck of endocytic buds. Upon GTP hydrolysis, conformational changes reduce the helical radius and pitch showing that fission proceeds through a constriction mechanism. We show that the deformation of Dynamin helices is highly concerted and damped by the friction between membrane and Dy...

  12. Selectron NLSP in Gauge Mediation

    CERN Document Server

    Calibbi, Lorenzo; Petersson, Christoffer; Redigolo, Diego

    2014-01-01

    We discuss gauge mediation models in which the smuon and the selectron are mass-degenerate co-NLSP, which we, for brevity, refer to as selectron NLSP. In these models, the stau, as well as the other superpartners, are parametrically heavier than the NLSP. We start by taking a bottom-up perspective and investigate the conditions under which selectron NLSP spectra can be realized in the MSSM. We then give a complete characterization of gauge mediation models realizing such spectra at low energies. The splitting between the slepton families is induced radiatively by the usual hierarchies in the Standard Model Yukawa couplings and hence, no new sources of flavour misalignment are introduced. We construct explicit weakly coupled messenger models which give rise to selectron NLSP, while accommodating a 126 GeV MSSM Higgs mass, both within the framework of General Gauge Mediation and in extensions where direct couplings between the messengers and the Higgs fields are present. In the latter class of models, large A-t...

  13. LHC signature of mirage mediation

    International Nuclear Information System (INIS)

    We study LHC phenomenology of mirage mediation scenario in which anomaly and modulus contributions to soft SUSY breaking terms are comparable to each other. A Monte Carlo study of mirage mediation, with model parameters α = 1, M0 = 500 GeV, nM = 1/2, nH = 1 and tan β = 10, is presented. It is shown that masses of supersymmetric particles can be measured in a model independent way, providing information on SUSY breaking sector. In particular, the mass ratio of gluino to the lightest neutralino for the benchmark scenario is determined to be 1.9 ∼g-tilde/mχ-tilde10 ∼g-tilde/mχ-tilde10 ≅ 2.5 which is quite distinctive from the predictions mg-tilde/mχ-tilde10 ∼> 6 of other SUSY scenarios in which gaugino masses are unified at the GUT scale. The model parameters of mirage mediation can be also determined from various kinematic distributions

  14. Flavor mediation delivers natural SUSY

    Science.gov (United States)

    Craig, Nathaniel; McCullough, Matthew; Thaler, Jesse

    2012-06-01

    If supersymmetry (SUSY) solves the hierarchy problem, then naturalness considerations coupled with recent LHC bounds require non-trivial superpartner flavor structures. Such "Natural SUSY" models exhibit a large mass hierarchy between scalars of the third and first two generations as well as degeneracy (or alignment) among the first two generations. In this work, we show how this specific beyond the standard model (SM) flavor structure can be tied directly to SM flavor via "Flavor Mediation". The SM contains an anomaly-free SU(3) flavor symmetry, broken only by Yukawa couplings. By gauging this flavor symmetry in addition to SM gauge symmetries, we can mediate SUSY breaking via (Higgsed) gauge mediation. This automatically delivers a natural SUSY spectrum. Third-generation scalar masses are suppressed due to the dominant breaking of the flavor gauge symmetry in the top direction. More subtly, the first-two-generation scalars remain highly degenerate due to a custodial U(2) symmetry, where the SU(2) factor arises because SU(3) is rank two. This custodial symmetry is broken only at order ( m c /m t )2. SUSY gauge coupling unification predictions are preserved, since no new charged matter is introduced, the SM gauge structure is unaltered, and the flavor symmetry treats all matter multiplets equally. Moreover, the uniqueness of the anomaly-free SU(3) flavor group makes possible a number of concrete predictions for the superpartner spectrum.

  15. Flavor Mediation Delivers Natural SUSY

    CERN Document Server

    Craig, Nathaniel; Thaler, Jesse

    2012-01-01

    If supersymmetry (SUSY) solves the hierarchy problem, then naturalness considerations coupled with recent LHC bounds require non-trivial superpartner flavor structures. Such "Natural SUSY" models exhibit a large mass hierarchy between scalars of the third and first two generations as well as degeneracy (or alignment) among the first two generations. In this work, we show how this specific beyond the standard model (SM) flavor structure can be tied directly to SM flavor via "Flavor Mediation". The SM contains an anomaly-free SU(3) flavor symmetry, broken only by Yukawa couplings. By gauging this flavor symmetry in addition to SM gauge symmetries, we can mediate SUSY breaking via (Higgsed) gauge mediation. This automatically delivers a natural SUSY spectrum. Third-generation scalar masses are suppressed due to the dominant breaking of the flavor gauge symmetry in the top direction. More subtly, the first-two-generation scalars remain highly degenerate due to a custodial U(2) symmetry, where the SU(2) factor ari...

  16. Substrate mediated enzyme prodrug therapy.

    Directory of Open Access Journals (Sweden)

    Betina Fejerskov

    Full Text Available In this report, we detail Substrate Mediated Enzyme Prodrug Therapy (SMEPT as a novel approach in drug delivery which relies on enzyme-functionalized cell culture substrates to achieve a localized conversion of benign prodrug(s into active therapeutics with subsequent delivery to adhering cells or adjacent tissues. For proof-of-concept SMEPT, we use surface adhered micro-structured physical hydrogels based on poly(vinyl alcohol, β-glucuronidase enzyme and glucuronide prodrugs. We demonstrate enzymatic activity mediated by the assembled hydrogel samples and illustrate arms of control over rate of release of model fluorescent cargo. SMEPT was not impaired by adhering cells and afforded facile time - and dose - dependent uptake of the in situ generated fluorescent cargo by hepatic cells, HepG2. With the use of a glucuronide derivative of an anticancer drug, SN-38, SMEPT afforded a decrease in cell viability to a level similar to that achieved using parent drug. Finally, dose response was achieved using SMEPT and administration of judiciously chosen concentration of SN-38 glucuronide prodrug thus revealing external control over drug delivery using drug eluting surface. We believe that this highly adaptable concept will find use in diverse biomedical applications, specifically surface mediated drug delivery and tissue engineering.

  17. Protected areas and poverty

    OpenAIRE

    Brockington, Daniel; Wilkie, David

    2015-01-01

    Protected areas are controversial because they are so important for conservation and because they distribute fortune and misfortune unevenly. The nature of that distribution, as well as the terrain of protected areas themselves, have been vigorously contested. In particular, the relationship between protected areas and poverty is a long-running debate in academic and policy circles. We review the origins of this debate and chart its key moments. We then outline the continuing flashpoints and ...

  18. Area studies after poststructuralism

    OpenAIRE

    J K Gibson-Graham

    2004-01-01

    In this paper we address the question of 'what next after poststructuralism' through a reassessment of area studies. In a narrative of our own involvement with place-oriented research and institutions, we examine the traditional position of area studies in geography and anthropology and its reevaluation by poststructuralist scholars in a number of disciplines. We argue that both prestructuralist and poststructuralist treatments of areas are oriented by a narrative of capitalist development; a...

  19. Optimal Currency Area Revisited

    OpenAIRE

    Yves Mersch

    2011-01-01

    Several euro area member states are under increased market scrutiny although public finances in the euro area as a bloc are in a much better shape than in the US or Japan. The main reason is that the euro area is an alliance of sovereign countries with most of the relevant political decisions - including public finance - being taken by national governments whereas the other major currencies are sovereign states with central governments and budgets. In the absence of a central government and a...

  20. Segmentation with Area Constraints

    OpenAIRE

    Niethammer, Marc; Zach, Christopher

    2012-01-01

    Image segmentation approaches typically incorporate weak regularity conditions such as boundary length or curvature terms, or use shape information. High-level information such as a desired area or volume, or a particular topology are only implicitly specified. In this paper we develop a segmentation method with explicit bounds on the segmented area. Area constraints allow for the soft selection of meaningful solutions, and can counteract the shrinking bias of length-based regularization. We ...

  1. Mediation, Mandatory Information and Facultative Applicability

    Directory of Open Access Journals (Sweden)

    Mihail-Silviu Pocora

    2014-05-01

    Full Text Available Considering that mediation is a facilitating way to access the alternative solving of litigations in conciliatory terms, the study is encouraging using the mediation and providing a balanced relationship between mediation and judiciary procedures. As an aftermath of summary definition, we can say that role of mediation is to overcome the communicative barriers in order to solve the conflict and save the fact situation on both parts. The study aims to analyze objectively all consequences of both solving ways of litigations: traditional one, through the law court and mediation, with the advantages derived from them (celerity vs. time consuming, expensive judiciary proceedings vs. low costs, etc.

  2. CVP Service Area

    Data.gov (United States)

    California Department of Resources — Federal Water Contract Service Area boundaries are incorporated boundaries of districts having contracts with the U.S. Bureau of Reclamation (Reclamation), within...

  3. Instilling a mediation-based conflict resolution culture.

    Science.gov (United States)

    Miller, M; Wax, D

    1999-01-01

    Conflict thrives and grows in the increasingly competitive and uncertain health care environment. Conflict impacts health care organizations' performance in several areas: (1) patient grievances and health plan member disputes; (2) internal employee and management disputes; and (3) payer, provider, and vendor disputes. "Grief Budgets," the hard costs and soft costs due to disputes that are poorly handled and conflicts that are ignored, detract from an organizations health mission and erode its bottom line. This article offers a strategy to solve conflict at an early stage in all three areas, with measurable results that strengthen profits and improve customer service by instilling a mediation-based conflict resolution culture throughout the organization. Mediation is non-adversarial, neutral, proactive, and collaborative. It is also confidential and always protects the future relationship between the parties. The challenge, therefore, is to strategically implant mediation into the health care organization's structure, to intercept and solve conflict early on. The article provides an overview of the steps needed to install a dispute resolution program. PMID:10557485

  4. Comprehensive area assessment consultation

    OpenAIRE

    Sustainable Development Commission

    2008-01-01

    The proposals for the new comprehensive area assessment are a very positive step forward for sustainable development compared to previous local performance assessment frameworks, but will need further strengthening if they are to help support the Government's aim of putting sustainable development at the heart of sustainable community strategies and their delivery mechanism, local area agreements. Publisher PDF

  5. Management of mangrove areas

    OpenAIRE

    1995-01-01

    The article discusses the management of mangrove areas in the Philippines to prevent further negative effects of mangrove depletion on the income of coastal fishers. The article suggests that the conversion of mangrove areas should be regulated by means of land lease.

  6. Mediation et violences conjugales Mediation and Domestic Violence

    Directory of Open Access Journals (Sweden)

    Jacques Faget

    2009-11-01

    Full Text Available Ce travail analyse  les potentialités et les limites du recours à la médiation en matière de régulation des violences conjugales.S’appuyant sur une étude empirique de sa mise en œuvre en France et sur la littérature scientifique existante il révèle l’existence de deux modèles de pratique reflétant deux conceptions de la médiation et plus généralement de l’articulation entre régulations pénales et sociales.This paper analyzes the potential and limits of recourse to mediation for regulating domestic violence. On the basis of an empirical study of its implementation in France and of the existing academic literature, it shows the existence of two types of practices reflecting two conceptions of mediation and more generally, two conceptions of the articulation between social and penal regulation. Full Text

  7. Mediated electrochemical hazardous waste destruction

    International Nuclear Information System (INIS)

    There are few permitted processes for mixed waste (radioactive plus chemically hazardous) treatment. We are developing an electrochemical process, based upon mediated electrochemical oxidation (MEO), that converts toxic organic components of mixed waste to water, carbon dioxide, and chloride or chloride precipitates. Aggressive oxidizer ions such as Ag2+, Co3+, or Fe3+ are produced at an anode. These can attack organic molecules directly, and may also produce hydroxyl free radicals that promote destruction. Solid and liquid radioactive waste streams containing only inorganic radionuclide forms may be treated with existing technology and prepared for final disposal. The coulombic efficiency of the process has been determined, as well as the destruction efficiency for ethylene glycol, a surrogate waste. In addition, hazardous organic materials are becoming very expensive to dispose of and when they are combined with transuranic radioactive elements no processes are presently permitted. Mediated electrochemical oxidation is an ambient- temperature aqueous-phase process that can be used to oxidize organic components of mixed wastes. Problems associated with incineration, such as high-temperature volatilization of radionuclides, are avoided. Historically, Ag(II) has been used as a mediator in this process. Fe(III) and Co(III) are attractive alternatives to Ag(II) since they form soluble chlorides during the destruction of chlorinated solvents. Furthermore, silver itself is toxic heavy metal. Quantitative data have been obtained for the complete oxidation of ethylene glycol by Fe(III) and Co(III). Though ethylene glycol is a nonhalogenated organic, these data have enabled us to make direct comparisons of activities of Fe(III) and Co(III) with Ag(II). Very good quantitative data for the oxidation of ethylene glycol by Ag(II) had already been collected

  8. Hydrological models are mediating models

    Science.gov (United States)

    Babel, L. V.; Karssenberg, D.

    2013-08-01

    Despite the increasing role of models in hydrological research and decision-making processes, only few accounts of the nature and function of models exist in hydrology. Earlier considerations have traditionally been conducted while making a clear distinction between physically-based and conceptual models. A new philosophical account, primarily based on the fields of physics and economics, transcends classes of models and scientific disciplines by considering models as "mediators" between theory and observations. The core of this approach lies in identifying models as (1) being only partially dependent on theory and observations, (2) integrating non-deductive elements in their construction, and (3) carrying the role of instruments of scientific enquiry about both theory and the world. The applicability of this approach to hydrology is evaluated in the present article. Three widely used hydrological models, each showing a different degree of apparent physicality, are confronted to the main characteristics of the "mediating models" concept. We argue that irrespective of their kind, hydrological models depend on both theory and observations, rather than merely on one of these two domains. Their construction is additionally involving a large number of miscellaneous, external ingredients, such as past experiences, model objectives, knowledge and preferences of the modeller, as well as hardware and software resources. We show that hydrological models convey the role of instruments in scientific practice by mediating between theory and the world. It results from these considerations that the traditional distinction between physically-based and conceptual models is necessarily too simplistic and refers at best to the stage at which theory and observations are steering model construction. The large variety of ingredients involved in model construction would deserve closer attention, for being rarely explicitly presented in peer-reviewed literature. We believe that devoting

  9. Membrane tension and peripheral protein density mediate membrane shape transitions

    Science.gov (United States)

    Shi, Zheng; Baumgart, Tobias

    2015-01-01

    Endocytosis is a ubiquitous eukaryotic membrane budding, vesiculation and internalization process fulfilling numerous roles including compensation of membrane area increase after bursts of exocytosis. The mechanism of the coupling between these two processes to enable homeostasis is not well understood. Recently, an ultrafast endocytosis (UFE) pathway was revealed with a speed significantly exceeding classical clathrin-mediated endocytosis (CME). Membrane tension reduction is a potential mechanism by which endocytosis can be rapidly activated at remote sites. Here, we provide experimental evidence for a mechanism whereby membrane tension reduction initiates membrane budding and tubulation mediated by endocytic proteins, such as endophilin A1. We find that shape instabilities occur at well-defined membrane tensions and surface densities of endophilin. From our data, we obtain a membrane shape stability diagram that shows remarkable consistency with a quantitative model. This model applies to all laterally diffusive curvature-coupling proteins and therefore a wide range of endocytic proteins.

  10. The evolution of inflammatory mediators

    Directory of Open Access Journals (Sweden)

    Andrew F. Rowley

    1996-01-01

    Full Text Available Invertebrates do not display the level of sophistication in immune reactivity characteristic of mammals and other ‘higher’ vertebrates. Their great number and diversity of forms, however, reflect their evolutionary success and hence they must have effective mechanisms of defence to deal with parasites and pathogens and altered self tissues. Inflammation appears to be an important first line defence in all invertebrates and vertebrates. This brief review deals with the inflammatory responses of invertebrates and fish concentrating on the cell types involved and the mediators of inflammation, in particular, eicosanoids, cytokines and adhesion molecules.

  11. Universality in pure gravity mediation

    International Nuclear Information System (INIS)

    If low-energy supersymmetry is realized in nature, the apparent discovery of a Higgs boson with mass around 125 GeV suggests a supersymmetric mass spectrum in the TeV or multi-TeV range. Multi-TeV scalar masses are a necessary component of supersymmetric models with pure gravity mediation or in any model with strong moduli stabilization. Here, we show that full scalar mass universality remains viable as long as the ratio of Higgs vevs, tanβ, is relatively small (< or similar 2.5). We discuss in detail the low-energy (observable) consequences of these models. (orig.)

  12. Protected areas and poverty

    Science.gov (United States)

    Brockington, Daniel; Wilkie, David

    2015-01-01

    Protected areas are controversial because they are so important for conservation and because they distribute fortune and misfortune unevenly. The nature of that distribution, as well as the terrain of protected areas themselves, have been vigorously contested. In particular, the relationship between protected areas and poverty is a long-running debate in academic and policy circles. We review the origins of this debate and chart its key moments. We then outline the continuing flashpoints and ways in which further evaluation studies could improve the evidence base for policy-making and conservation practice. PMID:26460124

  13. Do Quiet Areas Afford Greater Health-Related Quality of Life than Noisy Areas?

    Directory of Open Access Journals (Sweden)

    Kim N. Dirks

    2013-03-01

    Full Text Available People typically choose to live in quiet areas in order to safeguard their health and wellbeing. However, the benefits of living in quiet areas are relatively understudied compared to the burdens associated with living in noisy areas. Additionally, research is increasingly focusing on the relationship between the human response to noise and measures of health and wellbeing, complementing traditional dose-response approaches, and further elucidating the impact of noise and health by incorporating human factors as mediators and moderators. To further explore the benefits of living in quiet areas, we compared the results of health-related quality of life (HRQOL questionnaire datasets collected from households in localities differentiated by their soundscapes and population density: noisy city, quiet city, quiet rural, and noisy rural. The dose-response relationships between noise annoyance and HRQOL measures indicated an inverse relationship between the two. Additionally, quiet areas were found to have higher mean HRQOL domain scores than noisy areas. This research further supports the protection of quiet locales and ongoing noise abatement in noisy areas.

  14. 300 AREA URANIUM CONTAMINATION

    International Nuclear Information System (INIS)

    (smbullet) Uranium fuel production (smbullet) Test reactor and separations experiments (smbullet) Animal and radiobiology experiments conducted at the. 331 Laboratory Complex (smbullet) .Deactivation, decontamination, decommissioning,. and demolition of 300 Area facilities

  15. Pilot Boarding Areas

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Pilot boarding areas are locations at sea where pilots familiar with local waters board incoming vessels to navigate their passage to a destination port. Pilotage...

  16. Decontamination & decommissioning focus area

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    In January 1994, the US Department of Energy Office of Environmental Management (DOE EM) formally introduced its new approach to managing DOE`s environmental research and technology development activities. The goal of the new approach is to conduct research and development in critical areas of interest to DOE, utilizing the best talent in the Department and in the national science community. To facilitate this solutions-oriented approach, the Office of Science and Technology (EM-50, formerly the Office of Technology Development) formed five Focus AReas to stimulate the required basic research, development, and demonstration efforts to seek new, innovative cleanup methods. In February 1995, EM-50 selected the DOE Morgantown Energy Technology Center (METC) to lead implementation of one of these Focus Areas: the Decontamination and Decommissioning (D & D) Focus Area.

  17. ABACC's nuclear accounting area

    International Nuclear Information System (INIS)

    The functions and activities of the Brazilian-Argentine Agency for the Accounting and Control of Nuclear Materials (ABACC) accounting area is outlined together with a detailed description of the nuclear accounting system used by the bilateral organization

  18. Neural networks mediating sentence reading in the deaf

    Science.gov (United States)

    Hirshorn, Elizabeth A.; Dye, Matthew W. G.; Hauser, Peter C.; Supalla, Ted R.; Bavelier, Daphne

    2014-01-01

    The present work addresses the neural bases of sentence reading in deaf populations. To better understand the relative role of deafness and spoken language knowledge in shaping the neural networks that mediate sentence reading, three populations with different degrees of English knowledge and depth of hearing loss were included—deaf signers, oral deaf and hearing individuals. The three groups were matched for reading comprehension and scanned while reading sentences. A similar neural network of left perisylvian areas was observed, supporting the view of a shared network of areas for reading despite differences in hearing and English knowledge. However, differences were observed, in particular in the auditory cortex, with deaf signers and oral deaf showing greatest bilateral superior temporal gyrus (STG) recruitment as compared to hearing individuals. Importantly, within deaf individuals, the same STG area in the left hemisphere showed greater recruitment as hearing loss increased. To further understand the functional role of such auditory cortex re-organization after deafness, connectivity analyses were performed from the STG regions identified above. Connectivity from the left STG toward areas typically associated with semantic processing (BA45 and thalami) was greater in deaf signers and in oral deaf as compared to hearing. In contrast, connectivity from left STG toward areas identified with speech-based processing was greater in hearing and in oral deaf as compared to deaf signers. These results support the growing literature indicating recruitment of auditory areas after congenital deafness for visually-mediated language functions, and establish that both auditory deprivation and language experience shape its functional reorganization. Implications for differential reliance on semantic vs. phonological pathways during reading in the three groups is discussed. PMID:24959127

  19. USW area analogs

    OpenAIRE

    Everett, Keith R.

    2005-01-01

    The purpose of this project is to investigate the feasibility of and methodology for the development of a set of environmental analogs of operational Undersea Warfare (USW) areas within fleet training areas. It is primarily a discussion of the identification of parameters that characterize the tactical USW environment, prioritization of these parameters, identification of existing databases that contain these parameters and an outline of the processes required to extract the desired data fro...

  20. Drainage of radioactive areas

    International Nuclear Information System (INIS)

    This Code of Practice covers all the drainage systems which may occur in the radioactive classified area of an establishment, namely surface water, foul, process and radioactive drainage. It also deals with final discharge lines. The Code of Practice concentrates on those aspects of drainage which require particular attention because the systems are in or from radioactive areas and typical illustrations are given in appendices. The Code makes references to sources of information on conventional aspects of drainage design. (author)

  1. Plasma-mediated ablation of biofilm contamination

    Science.gov (United States)

    Guo, Zhixiong; Wang, Xiaoliang; Huang, Huan

    2010-12-01

    Ultra-short pulsed laser removal of thin biofilm contamination on different substrates has been conducted via the use of plasma-mediated ablation. The biofilms were formed using sheep whole blood. The ablation was generated using a 1.2 ps ultra-short pulsed laser with wavelength centered at 1552 nm. The blood contamination was transformed into plasma and collected with a vacuum system. The single line ablation features have been measured. The ablation thresholds of blood contamination and bare substrates were determined. It is found that the ablation threshold of the blood contamination is lower than those of the beneath substrates including the glass slide, PDMS, and human dermal tissues. The ablation effects of different laser parameters (pulse overlap rate and pulse energy) were studied and ablation efficiency was measured. Proper ablation parameters were found to efficiently remove contamination with maximum efficiency and without damage to the substrate surface for the current laser system. Complete removal of blood contaminant from the glass substrate surface and freeze-dried dermis tissue surface was demonstrated by the USP laser ablation with repeated area scanning. No obvious thermal damage was found in the decontaminated glass and tissue samples.

  2. Theorizing Mediation: Lessons Learned from Legal Anthropology

    Directory of Open Access Journals (Sweden)

    Marc Simon Thomas

    2016-01-01

    Full Text Available Since the 1990s, there has been an increasing interest in mediation in the Netherlands, as part of a set of ‘alternative dispute resolution’ methods. Politicians, lawyers and practitioners have embraced mediation as a legitimate method for settling disputes, alongside the adjudication of conflicts in courts of law. However, there is a striking lack of literature aimed at theorizing mediation from a legal perspective. This article argues that the legal anthropology literature on disputes and dispute settlement offers useful insights for understanding mediation from a ‘legal research’ point of view. This is because a lot of current common knowledge on mediation has its roots in a legal anthropological understanding. The argument that is set forth in this article is that the most important lesson that can be learned is that mediation should not be seen in isolation, but as part of a social process.

  3. Legal and Psychological Aspects of Mediation

    Directory of Open Access Journals (Sweden)

    Dobrokhotova E. N.

    2016-01-01

    Full Text Available The article focuses on gradual innovation of mediation into the practice of social conflict resolution in the light of legal and psychological means of mediation. While mediation is perceived as a conflictological concept and is more widely used in dispute settlement and resolution, a new interdisciplinary field of theoretical knowledge with its own conceptual framework as well as a new professional and practical field are beginning to form both in Russia and in other countries. As theoretical and practical aspects of innovation in mediation require consolidation not only for its national development but also for the guaranteed international cooperation, the article touches upon some of the particular theoretical issues of the topic in question: terminological consistency, consolidation of the system of mediation principles, the phenomenon of juridisation of mediation and its limits.

  4. Sparticle masses in deflected mirage mediation

    CERN Document Server

    Choi, Kiwoon; Nakamura, Shuntaro; Okumura, Ken-Ichi; Yamaguchi, Masahiro

    2009-01-01

    We discuss the sparticle mass patterns that can be realized in deflected mirage mediation scenario of supersymmetry breaking, in which the moduli, anomaly, and gauge mediations all contribute to the MSSM soft parameters. Analytic expression of low energy soft parameters and also the sfermion mass sum rules are derived, which can be used to interpret the experimentally measured sparticle masses within the framework of the most general mixed moduli-gauge-anomaly mediation. Phenomenological aspects of some specific examples are also discussed.

  5. The Economics of First-Contract Mediation

    OpenAIRE

    Dobbelaere, Sabien; LUTTENS, Roland Iwan

    2013-01-01

    This paper provides an economic foundation for non-binding mediation to stimulate first collective bargaining agreements, as implemented in British Columbia since 1993. We show that the outcome of first-contract mediation is Pareto efficient and proves immune to the insider-outsider problem of underhiring. We also demonstrate that equilibrium wages and profits under mediation coincide with the Owen values of the corresponding cooperative game with the coalitional structure that follows from u...

  6. Causal Mediation Analyses for Randomized Trials

    OpenAIRE

    Lynch, Kevin G.; Cary, Mark; Gallop, Robert; Ten Have, Thomas R.

    2008-01-01

    In the context of randomized intervention trials, we describe causal methods for analyzing how post-randomization factors constitute the process through which randomized baseline interventions act on outcomes. Traditionally, such mediation analyses have been undertaken with great caution, because they assume that the mediating factor is also randomly assigned to individuals in addition to the randomized baseline intervention (i.e., sequential ignorability). Because the mediating factors are t...

  7. Community Mediation. A Model for Romania

    Directory of Open Access Journals (Sweden)

    Christian Radu CHEREJI

    2014-02-01

    Full Text Available Community mediation takes all forms and shapes all over the world. In order to better understand its limitations in adapting to different contexts, we have compared the evolution of community mediation services in two totally different systems, USA and Sri Lanka. Based on this analysis and the results of a research conducted in Cluj-Napoca in the fall of 2013, we have recommended a community mediation model suitable for the current Romanian social, economic and cultural framework.

  8. Resolvins and protectins: mediating solutions to inflammation

    OpenAIRE

    Kohli, Payal; Levy, Bruce D.

    2009-01-01

    Resolution of inflammation has historically been viewed as a passive process, occurring as a result of the withdrawal of pro-inflammatory signals, including lipid mediators such as leukotrienes and prostaglandins. Thus, most anti-inflammatory drugs have traditionally targeted primarily mediator pathways that are engaged at the onset of inflammation. Only recently has it been established that inflammation resolution is an active process with a distinct set of chemical mediators. Several clinic...

  9. Confounding in the Estimation of Mediation Effects

    OpenAIRE

    Li, Y.; Bienias, J.L.; Bennett, D. A.

    2007-01-01

    A mediation effect explains the relationship of a risk factor and an outcome through a mediator variable which is a step in their pathway. Under the assumption of no cycling in the causal relationship, we consider various situations in which a fourth variable may interfere the estimation of a mediation effect as a confounding factor. Our asymptotic results, which are supported by a Monte Carlo study, show that adjusting for confounding factors under certain conditions ...

  10. Sparticle masses in deflected mirage mediation

    International Nuclear Information System (INIS)

    We discuss the sparticle mass patterns that can be realized in deflected mirage mediation scenario of supersymmetry breaking, in which the moduli, anomaly, and gauge mediations all contribute to the MSSM soft parameters. Analytic expression of low energy soft parameters and also the sfermion mass sum rules are derived, which can be used to interpret the experimentally measured sparticle masses within the framework of the most general mixed moduli-gauge-anomaly mediation. Phenomenological aspects of some specific examples are also discussed.

  11. Focus point supersymmetry in extended gauge mediation

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Ran [School of Physics, Nankai University,Tianjin 300071 (China); Li, Tianjun [State Key Laboratory of Theoretical Physics and Kavli Institute for Theoretical Physics (KITPC),Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190 (China); School of Physical Electronics, University of Electronic Science and Technology of China,Chengdu 610054 (China); Staub, Florian [Bethe Center for Theoretical Physics & Physikalisches Institut der Universität Bonn,Nußallee 12, 53115 Bonn (Germany); Zhu, Bin [School of Physics, Nankai University,Tianjin 300071 (China)

    2014-03-27

    We propose a small extension of the minimal gauge mediation through the combination of extended gauge mediation and conformal sequestering. We show that the focus point supersymmetry can be realized naturally, and the fine tuning is significantly reduced compared to the minimal gauge mediation and extended gauge mediation without focus point. The Higgs boson mass is around 125 GeV, the gauginos remain light, and the gluino is likely to be detected at the next run of the LHC. However, the multi-TeV squarks is out of the reach of the LHC. The numerical calculation for fine-tuning shows that this model remains natural.

  12. Focus point supersymmetry in extended gauge mediation

    International Nuclear Information System (INIS)

    We propose a small extension of the minimal gauge mediation through the combination of extended gauge mediation and conformal sequestering. We show that the focus point supersymmetry can be realized naturally, and the fine tuning is significantly reduced compared to the minimal gauge mediation and extended gauge mediation without focus point. The Higgs boson mass is around 125 GeV, the gauginos remain light, and the gluino is likely to be detected at the next run of the LHC. However, the multi-TeV squarks is out of the reach of the LHC. The numerical calculation for fine-tuning shows that this model remains natural

  13. 200 Area Interim Storage Area Technical Safety Requirements

    International Nuclear Information System (INIS)

    The 200 Area Interim Storage Area Technical Safety Requirements define administrative controls and design features required to ensure safe operation during receipt and storage of canisters containing spent nuclear fuel. This document is based on the 200 Area Interim Storage Area, Annex D, Final Safety Analysis Report which contains information specific to the 200 Area Interim Storage Area

  14. Phenomenological aspects of mirage mediation

    International Nuclear Information System (INIS)

    We consider the possibility that string theory vacua with spontaneously broken supersymmetry and a small positive cosmological constant arise due to hidden sector matter interactions, known as F-uplifting/F-downlifting. We analyze this procedure in a model-independent way in the context of type IIB and heterotic string theory. Our investigation shows that the uplifting/downlifting sector has very important consequences for the resulting phenomenology. Not only does it adjust the vacuum energy, but it can also participate in the process of moduli stabilization. In addition, we find that this sector is the dominant source of supersymmetry breaking. It leads to a hybrid mediation scheme and its signature is a relaxed mirage pattern of the soft supersymmetry breaking terms. The low energy spectra exhibit distinct phenomenological properties and di er from conventional schemes considered so far. (orig.)

  15. Endothelin receptor-mediated vasodilatation

    DEFF Research Database (Denmark)

    Nilsson, David; Wackenfors, Angelica; Gustafsson, Lotta;

    2008-01-01

    Culture of intact arteries is a frequently employed experimental model for investigating the mechanisms governing the regulation of vascular endothelin receptors. Endothelin type A (ET(A)) and type B (ET(B)) receptors on vascular smooth muscle cells are up-regulated in organ culture and the...... enhanced vasoconstriction mimics the changes that occur in cardiovascular disease. The effect of organ culture on endothelial dilatory endothelin ET(B) receptors is not known. We hypothesize that organ culture decreases the endothelin receptor-mediated dilatation and that this is one possible mechanism by...... denudation. The increase in sarafotoxin 6c contraction after removal of the endothelium was more pronounced before than after organ culture, suggesting down-regulated endothelial endothelin ET(B) receptors. Also, the immunofluorescence staining intensities for endothelial endothelin ET(B) receptors were...

  16. Hyaluronan-mediated cellular adhesion

    Science.gov (United States)

    Curtis, Jennifer

    2005-03-01

    Many cells surround themselves with a cushioning halo of polysaccharides that is further strengthened and organized by proteins. In fibroblasts and chrondrocytes, the primary component of this pericellular matrix is hyaluronan, a large linear polyanion. Hyaluronan production is linked to a variety of disease, developmental, and physiological processes. Cells manipulate the concentration of hyaluronan and hyaluronan receptors for numerous activities including modulation of cell adhesion, cell motility, and differentiation. Recent investigations by identify hyaluronan's role in mediating early-stage cell adhesion. An open question is how the cell removes the 0.5-10 micron thick pericellular matrix to allow for further mature adhesion events requiring nanometer scale separations. In this investigation, holographic optical tweezers are used to study the adhesion and viscoelastic properties of chondrocytes' pericellular matrix. Ultimately, we aim to shed further light on the spatial and temporal details of the dramatic transition from micron to nanometer gaps between the cell and its adhesive substrate.

  17. Phenomenological aspects of mirage mediation

    Energy Technology Data Exchange (ETDEWEB)

    Loewen, Valeri

    2009-07-15

    We consider the possibility that string theory vacua with spontaneously broken supersymmetry and a small positive cosmological constant arise due to hidden sector matter interactions, known as F-uplifting/F-downlifting. We analyze this procedure in a model-independent way in the context of type IIB and heterotic string theory. Our investigation shows that the uplifting/downlifting sector has very important consequences for the resulting phenomenology. Not only does it adjust the vacuum energy, but it can also participate in the process of moduli stabilization. In addition, we find that this sector is the dominant source of supersymmetry breaking. It leads to a hybrid mediation scheme and its signature is a relaxed mirage pattern of the soft supersymmetry breaking terms. The low energy spectra exhibit distinct phenomenological properties and di er from conventional schemes considered so far. (orig.)

  18. Modeling expert knowledge in the mediation domain: a mediation core ontology

    OpenAIRE

    Poblet, Marta; Casanovas, Pompeu

    2009-01-01

    In this paper we introduce the Mediation Core Ontology (MCO), and the steps taken in order to model the expert knowledge on the mediation domain. MCO is created from scratch by eliciting practical knowledge from mediation experts to identify the basic working concepts of the domain. MCO offers initial support towards knowledge acquisition and reasoning and, in later steps, will serve as a general basis for the development of different mediation domain and sub-domain ontologies to be used by ...

  19. Mediated electrochemical hazardous waste destruction

    International Nuclear Information System (INIS)

    There are few permitted processes for mixed waste (radioactive plus chemically hazardous) treatment. We are developing electrochemical processes that convert the toxic organic components of mixed waste to water, carbon dioxide, an innocuous anions such as chloride. Aggressive oxidizer ions such as Ag2+ or Ce+4 are produced at an anode. These can attack the organic molecules directly. They can also attack water which yields hydroxyl free radicals that in turn attack the organic molecules. The condensed (i.e., solid and/or liquid) effluent streams contain the inorganic radionuclide forms. These may be treated with existing technology and prepared for final disposal. Kinetics and the extent of destruction of some toxic organics have been measured. Depending on how the process is operated, coulombic efficiency can be nearly 100%. In addition, hazardous organic materials are becoming very expensive to dispose of and when they are combined with transuranic radioactive elements no processes are presently permitted. Mediated electrochemical oxidation is an ambient-temperature aqueous-phase process that can be used to oxidize organic components of mixed wastes. Problems associated with incineration, such as high-temperature volatilization of radionuclides, are avoided. Historically, Ag (2) has been used as a mediator in this process. Fe(6) and Co(3) are attractive alternatives to Ag(2) since they form soluble chlorides during the destruction of chlorinated solvents. Furthermore, silver itself is a toxic heavy metal. Quantitative data has been obtained for the complete oxidation of ethylene glycol by Fe(6) and Co(3). Though ethylene glycol is a nonhalogenated organic, this data has enabled us to make direct comparisons of activities of Fe(6) and Co(3) with Ag(2). Very good quantitative data for the oxidation of ethylene glycol by Ag(2) had already been collected. 4 refs., 6 figs

  20. Forms of Mediation: The Case of Interpreter-Mediated Interactions in Medical Systems

    Science.gov (United States)

    Baraldi, Claudio

    2009-01-01

    This paper analyses the forms of mediation in interlinguistic interactions performed in Italian healthcare services and in contexts of migration. The literature encourages dialogic transformative mediation, empowering participants' voices and changing cultural presuppositions in social systems. It may be doubtful, however, whether mediation can…

  1. Tests of Mediation: Paradoxical Decline in Statistical Power as a Function of Mediator Collinearity

    Science.gov (United States)

    Beasley, T. Mark

    2014-01-01

    Increasing the correlation between the independent variable and the mediator ("a" coefficient) increases the effect size ("ab") for mediation analysis; however, increasing a by definition increases collinearity in mediation models. As a result, the standard error of product tests increase. The variance inflation caused by…

  2. Mined area detection overview

    Science.gov (United States)

    Burch, Ian A.; Deas, Robert M.; Port, Daniel M.

    2002-08-01

    An overview of the progress on the UK MOD Applied Research Program for Land Mine Detection. The Defense Science and Technology Laboratory (Dstl) carries out and manages the whole of the UK MOD's Mined Area Detection Applied Research Program both within its own laboratories and in partnership with industrial and academic research organizations. This paper will address two specific areas of Applied Research: hand held mine detection and vehicle mounted mine detection in support of the Mine Detection Neutralization and Route Marking System which started in April 1997. Both are multi-sensor systems, incorporating between them metal detection, ground penetrating radar, nuclear quadrupole resonance, ultra-wideband radar, and polarized thermal imaging.

  3. Screening for domestic violence in family mediation: an investigation into how mediators manage disclosures of domestic abuse and associated emotions

    OpenAIRE

    Morris, Paulette Elaine

    2015-01-01

    This thesis was submitted for the award of Doctor of Philosophy and was awarded by Brunel University London This thesis explores the practice of family mediators when screening for domestic violence during mediation. Mediation Information and Assessment Meetings (MIAMs) and Joint Mediation Meetings (JMs) were recorded between April 2010 and January 2011, by four mediators who mediate for National Family Mediation (NFM) affiliated services in the South of England. These meetings were analys...

  4. On Mediation in Virtual Learning Environments.

    Science.gov (United States)

    Davies, Larry; Hassan, W. Shukry

    2001-01-01

    Discusses concepts of mediation and focuses on the importance of implementing comprehensive virtual learning environments. Topics include education and technology as they relate to cultural change, social institutions, the Internet and computer-mediated communication, software design and human-computer interaction, the use of MOOs, and language.…

  5. Is Retrieval Mediated after Repeated Testing?

    Science.gov (United States)

    Kole, James A.; Healy, Alice F.

    2013-01-01

    In 2 main experiments, the mediated priming effect was used to determine whether retrieval continues to be mediated after repeated testing. In each experiment, participants used the keyword method to learn French vocabulary, then completed a modified lexical decision task in which they first translated a French word, and then made a lexical…

  6. Computer-Mediated Communication and Shared Learning.

    Science.gov (United States)

    Dicks, Dennis J.

    1992-01-01

    Discussion of computer-mediated communication focuses on techniques developed to help groups of people communicate effectively, including cooperative learning, team building, groupware for cooperative work, decision support systems, organizational design, and shared learning. Implications for the design of computer-mediated communication systems…

  7. Parent Mediation Empowers Sibling Conflict Resolution

    Science.gov (United States)

    Ross, Hildy S.; Lazinski, Marysia J.

    2014-01-01

    Research Findings: For the current study, formal mediation procedures were adapted for families and parents were trained and asked to mediate their children's disputes; control group parents intervened as they normally would. Conflict negotiations with parents and their children (ages 3½-11 years) occurring 3 and 7 weeks following training,…

  8. Semiotic Mediation within an AT Frame

    Science.gov (United States)

    Maracci, Mirko; Mariotti, Maria Alessandra

    2013-01-01

    This article is meant to present a specific elaboration of the notion of mediation in relation to the use of artefacts to enhance mathematics teaching and learning: the elaboration offered by the Theory of Semiotic Mediation. In particular, it provides an explicit model--consistent with the activity-actions-operations framework--of the actions…

  9. Intercultural Conflict and Mediation: An Intergroup Perspective

    Science.gov (United States)

    Rubenfeld, Sara; Clement, Richard

    2012-01-01

    This study investigates the role of components of intercultural competence in the use of intercultural mediation behaviors. Through the use of the Revised Intercultural Mediation Measure, an instrument revised by the authors, 291 Anglophone and 161 Francophone participants in Canada were asked to indicate their likelihood of employing various…

  10. A Conceptual Framework for Mediated Environments

    Science.gov (United States)

    Childs, Mark

    2010-01-01

    Background: Immersive virtual worlds are one of a range of different platforms that can be grouped under the concept of mediated environments, i.e. environments that create a metaphorical space in which participants can position themselves and be embodied. Synthesising the literatures concerning the various mediated environment technologies…

  11. Plutonium focus area

    International Nuclear Information System (INIS)

    To ensure research and development programs focus on the most pressing environmental restoration and waste management problems at the U.S. Department of Energy (DOE), the Assistant Secretary for the Office of Environmental Management (EM) established a working group in August 1993 to implement a new approach to research and technology development. As part of this new approach, EM developed a management structure and principles that led to the creation of specific Focus Areas. These organizations were designed to focus the scientific and technical talent throughout DOE and the national scientific community on the major environmental restoration and waste management problems facing DOE. The Focus Area approach provides the framework for intersite cooperation and leveraging of resources on common problems. After the original establishment of five major Focus Areas within the Office of Technology Development (EM-50, now called the Office of Science and Technology), the Nuclear Materials Stabilization Task Group (EM-66) followed the structure already in place in EM-50 and chartered the Plutonium Focus Area (PFA). The following information outlines the scope and mission of the EM, EM-60, and EM-66 organizations as related to the PFA organizational structure

  12. Protected areas in mountains

    Directory of Open Access Journals (Sweden)

    Hamilton, L. S.

    2006-12-01

    Full Text Available

    The importance of a global Protected Areas Network in sustaining appropriate mountain development is presented in this paper. Present status of the world’s “official” Protected Areas in the UN List, and the proportion that are in mountain areas, and including international designations (World Heritage and Biosphere Reserves. Current and future challenges in the management of these special areas are also commented.



    El autor destaca la importancia de una Red Mundial de Espacios Protegidos para el desarrollo sostenible de las montañas. Comenta luego el estatus actual de las Áreas Protegidas “oficiales” del Mundo en la Lista de las Naciones Unidas y qué proporción de ellas forma parte de las montañas, sin olvidar las figuras internacionales de protección como Patrimonio de la Humanidad y Reservas de Biosfera. Para terminar, se discuten los problemas de gestión actuales y futuros de estas áreas tan especiales

  13. Counting on rectangular areas

    OpenAIRE

    Janjic, Milan

    2007-01-01

    In the first section of this paper we prove a theorem for the number of columns of a rectangular area that are identical to the given one. In the next section we apply this theorem to derive several combinatorial identities by counting specified subsets of a finite set.

  14. Subsurface contaminants focus area

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    The US Department of Enregy (DOE) Subsurface Contaminants Focus Area is developing technologies to address environmental problems associated with hazardous and radioactive contaminants in soil and groundwater that exist throughout the DOE complex, including radionuclides, heavy metals; and dense non-aqueous phase liquids (DNAPLs). More than 5,700 known DOE groundwater plumes have contaminated over 600 billion gallons of water and 200 million cubic meters of soil. Migration of these plumes threatens local and regional water sources, and in some cases has already adversely impacted off-site rsources. In addition, the Subsurface Contaminants Focus Area is responsible for supplying technologies for the remediation of numerous landfills at DOE facilities. These landfills are estimated to contain over 3 million cubic meters of radioactive and hazardous buried Technology developed within this specialty area will provide efective methods to contain contaminant plumes and new or alternative technologies for development of in situ technologies to minimize waste disposal costs and potential worker exposure by treating plumes in place. While addressing contaminant plumes emanating from DOE landfills, the Subsurface Contaminants Focus Area is also working to develop new or alternative technologies for the in situ stabilization, and nonintrusive characterization of these disposal sites.

  15. Stunned and necrotic areas

    International Nuclear Information System (INIS)

    It is evaluated if MRI, which is a multiplanar, multiparameteric, noninvasive technique with natural contrast between flowing blood and cardiac walls, has the capability to discriminate stunned from necrotic areas in better and more opportune way than ultrasound methods. (author). 8 refs.; 2 figs.; 2 tabs

  16. Area Handbook for Guatemala.

    Science.gov (United States)

    Dombrowski, John; And Others

    This volume is one of a series of handbooks prepared by Foreign Area Studies of American University designed to be useful to military and other personnel who need a convenient compilation of basic facts about the social, economic, political, and military institutions and practices of various countries. Chapters focus on: (1) the general character…

  17. Subsurface contaminants focus area

    International Nuclear Information System (INIS)

    The US Department of Enregy (DOE) Subsurface Contaminants Focus Area is developing technologies to address environmental problems associated with hazardous and radioactive contaminants in soil and groundwater that exist throughout the DOE complex, including radionuclides, heavy metals; and dense non-aqueous phase liquids (DNAPLs). More than 5,700 known DOE groundwater plumes have contaminated over 600 billion gallons of water and 200 million cubic meters of soil. Migration of these plumes threatens local and regional water sources, and in some cases has already adversely impacted off-site rsources. In addition, the Subsurface Contaminants Focus Area is responsible for supplying technologies for the remediation of numerous landfills at DOE facilities. These landfills are estimated to contain over 3 million cubic meters of radioactive and hazardous buried Technology developed within this specialty area will provide efective methods to contain contaminant plumes and new or alternative technologies for development of in situ technologies to minimize waste disposal costs and potential worker exposure by treating plumes in place. While addressing contaminant plumes emanating from DOE landfills, the Subsurface Contaminants Focus Area is also working to develop new or alternative technologies for the in situ stabilization, and nonintrusive characterization of these disposal sites

  18. Area Handbook for Syria.

    Science.gov (United States)

    Nyrop, Richard; And Others

    This volume on Syria is one of a series of handbooks prepared by the Foreign Area Studies (FAS) of the American University, designed to be useful to military and other personnel who need a convenient compilation of basic facts about the social, economic, political, and military institutions and practices of various countries. The emphasis is on…

  19. Causal Mediation Analyses for Randomized Trials.

    Science.gov (United States)

    Lynch, Kevin G; Cary, Mark; Gallop, Robert; Ten Have, Thomas R

    2008-01-01

    In the context of randomized intervention trials, we describe causal methods for analyzing how post-randomization factors constitute the process through which randomized baseline interventions act on outcomes. Traditionally, such mediation analyses have been undertaken with great caution, because they assume that the mediating factor is also randomly assigned to individuals in addition to the randomized baseline intervention (i.e., sequential ignorability). Because the mediating factors are typically not randomized, such analyses are unprotected from unmeasured confounders that may lead to biased inference. We review several causal approaches that attempt to reduce such bias without assuming that the mediating factor is randomized. However, these causal approaches require certain interaction assumptions that may be assessed if there is enough treatment heterogeneity with respect to the mediator. We describe available estimation procedures in the context of several examples from the literature and provide resources for software code. PMID:19484136

  20. Confounding in the Estimation of Mediation Effects.

    Science.gov (United States)

    Li, Yan; Bienias, Julia L; Bennett, David A

    2007-03-01

    A mediation effect explains the relationship of a risk factor and an outcome through a mediator variable which is a step in their pathway. Under the assumption of no cycling in the causal relationship, we consider various situations in which a fourth variable may interfere the estimation of a mediation effect as a confounding factor. Our asymptotic results, which are supported by a Monte Carlo study, show that adjusting for confounding factors under certain conditions might lead to biased estimates. A general guideline is provided for when it is appropriate to adjust for confounding factors in estimating a mediation effect. We apply the guideline to the estimation of the mediation effect of Alzheimer's disease pathology in the relationship between the Apolipoprotein E ε4 allele and cognitive function among 125 deceased participants from the Religious Orders Study, a longitudinal, clinical-pathologic study of aging and Alzheimer's disease. PMID:17940582

  1. Pure Mediated Priming: A Retrospective Semantic Matching Model

    Science.gov (United States)

    Jones, Lara L.

    2010-01-01

    Mediated priming refers to the activation of a target (e.g., "stripes") by a prime (e.g., "lion") that is related indirectly via a connecting mediator (e.g., tiger). In previous mediated priming studies (e.g., McNamara & Altarriba, 1988), the mediator was associatively related to the prime. In contrast, pure mediated priming (e.g., "spoon" [right…

  2. 7 CFR 785.5 - Fees for mediation services.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Fees for mediation services. 785.5 Section 785.5... AGRICULTURE SPECIAL PROGRAMS CERTIFIED STATE MEDIATION PROGRAM § 785.5 Fees for mediation services. A requirement that non-USDA parties who elect to participate in mediation pay a fee for mediation services...

  3. Online-Mediation - Erweist sich Online-Mediation als taugliches Instrument in Österreich?

    Directory of Open Access Journals (Sweden)

    Daniela Hinterhölzl-Widi

    2010-10-01

    Full Text Available Die vorliegende Arbeit beschäftigt sich mit der Thematik der Online-Mediation in Österreich. Es wird in einem breiten Bogen von relevanten Themen der Mediation das Tool Online-Mediation betrachtet und versucht das Wie und Was der Einsatzmöglichkeiten von Online-Mediation herauszuarbeiten. Die Fragestellung beschäftigt sich damit, ob Online-Mediation als Instrument und Methode gesehen wird und ob die Mediatoren über ausreichend Know-how in Online-Kommunikation verfügen.

  4. Online-Mediation - Erweist sich Online-Mediation als taugliches Instrument in Österreich?

    OpenAIRE

    Daniela Hinterhölzl-Widi

    2010-01-01

    Die vorliegende Arbeit beschäftigt sich mit der Thematik der Online-Mediation in Österreich. Es wird in einem breiten Bogen von relevanten Themen der Mediation das Tool Online-Mediation betrachtet und versucht das Wie und Was der Einsatzmöglichkeiten von Online-Mediation herauszuarbeiten. Die Fragestellung beschäftigt sich damit, ob Online-Mediation als Instrument und Methode gesehen wird und ob die Mediatoren über ausreichend Know-how in Online-Kommunikation verfügen.

  5. Effects of Training on Computer-Mediated Communication in Single or Mixed Gender Small Task Groups.

    Science.gov (United States)

    Savicki, Victor; Kelley, Merle; Ammon, Benjamin

    2002-01-01

    Investigates group gender composition and communication styles in small task groups involved in computer-mediated communication. Describes a study that tried to train small task groups in the use of one communication style and suggests further research in the area of communication training for online task groups. (Author/LRW)

  6. Effects of Gender on Computer-Mediated Communication: A Survey of University Faculty

    Science.gov (United States)

    Valenziano, Laura

    2007-01-01

    The influence of gender on computer-mediated communication is a research area with tremendous growth. This study sought to determine what gender effects exist in email communication between professors and students. The study also explored the amount of lying and misinterpretation that occurs through online communication. The study results indicate…

  7. Social Capital as a Mediating Factor in Emergency Preparedness and Concerns about Terrorism

    Science.gov (United States)

    Hausman, Alice J.; Hanlon, Alexandra; Seals, Brenda

    2007-01-01

    The purpose of this study was to investigate how social capital might be instrumental in mediating concerns about terrorism and promoting appropriate responses for emergency preparedness. Results are presented from a random-digit dialed survey of a metropolitan area measuring individual characteristics as well as community-level characteristics as…

  8. Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons.

    Science.gov (United States)

    Isingrini, Elsa; Perret, Léa; Rainer, Quentin; Amilhon, Bénédicte; Guma, Elisa; Tanti, Arnaud; Martin, Garance; Robinson, Jennifer; Moquin, Luc; Marti, Fabio; Mechawar, Naguib; Williams, Sylvain; Gratton, Alain; Giros, Bruno

    2016-04-01

    Dopamine (DA) neurons in the ventral tegmental area (VTA) help mediate stress susceptibility and resilience. However, upstream mechanisms controlling these neurons remain unknown. Noradrenergic (NE) neurons in the locus coeruleus, implicated in the pathophysiology of depression, have direct connections within the VTA. Here we demonstrate that NE neurons regulate vulnerability to social defeat through inhibitory control of VTA DA neurons. PMID:26878672

  9. Role of Transformational Leadership in Effective Organizational Knowledge Creation Practices: Mediating Effects of Employees' Work Engagement

    Science.gov (United States)

    Song, Ji Hoon; Kolb, Judith A.; Lee, Ung Hee; Kim, Hye Kyoung

    2012-01-01

    Engagement as an area of increasing interest has been discussed in terms of a wide array of organizational policies, practices, and outcomes. This study focuses on a specific aspect of work engagement and its relationship with leadership practices and the outcome of knowledge creation. The mediating effect of employees' work engagement level was…

  10. Learners' Perceived Value of Video as Mediation in Foreign Language Learning

    Science.gov (United States)

    Hung, Hsiu-Ting

    2009-01-01

    Video is commonly employed as curriculum enhancement in the foreign language classroom. The use of video as a mediation tool for language production tasks is relatively less cognizant by researchers and practitioners, which points to an area worthy of investigation. This study, therefore, aimed to examine the potential of learner video production…

  11. Atomic Force Microscope Mediated Chromatography

    Science.gov (United States)

    Anderson, Mark S.

    2013-01-01

    The atomic force microscope (AFM) is used to inject a sample, provide shear-driven liquid flow over a functionalized substrate, and detect separated components. This is demonstrated using lipophilic dyes and normal phase chromatography. A significant reduction in both size and separation time scales is achieved with a 25-micron-length column scale, and one-second separation times. The approach has general applications to trace chemical and microfluidic analysis. The AFM is now a common tool for ultra-microscopy and nanotechnology. It has also been demonstrated to provide a number of microfluidic functions necessary for miniaturized chromatography. These include injection of sub-femtoliter samples, fluidic switching, and sheardriven pumping. The AFM probe tip can be used to selectively remove surface layers for subsequent microchemical analysis using infrared and tip-enhanced Raman spectroscopy. With its ability to image individual atoms, the AFM is a remarkably sensitive detector that can be used to detect separated components. These diverse functional components of microfluidic manipulation have been combined in this work to demonstrate AFM mediated chromatography. AFM mediated chromatography uses channel-less, shear-driven pumping. This is demonstrated with a thin, aluminum oxide substrate and a non-polar solvent system to separate a mixture of lipophilic dyes. In conventional chromatographic terms, this is analogous to thin-layer chromatography using normal phase alumina substrate with sheardriven pumping provided by the AFM tip-cantilever mechanism. The AFM detection of separated components is accomplished by exploiting the variation in the localized friction of the separated components. The AFM tip-cantilever provides the mechanism for producing shear-induced flows and rapid pumping. Shear-driven chromatography (SDC) is a relatively new concept that overcomes the speed and miniaturization limitations of conventional liquid chromatography. SDC is based on a

  12. Mediation: A Process That Works (Some Practical Thoughts for School Systems on Mediation of Special Education Disputes).

    Science.gov (United States)

    Ekstrand, Richard E.

    The paper examines the issues and process involved in mediation of special education disputes. Mediation is an informal, optional procedure that may save time, money, and emotional strain for both staff and parents. Issues should not be mediated if there is no willingness to accept the mediation decision. Mediation should begin after all efforts…

  13. Sulphur bacteria mediated formation of Palaeoproterozoic phosphorites

    Science.gov (United States)

    Joosu, Lauri; Lepland, Aivo; Kirsimäe, Kalle

    2014-05-01

    Modern phosphorite formation is typically associated with high productivity in upwelling areas where apatite (Ca-phosphate) precipitation is mediated by sulphur oxidising bacteria [1]. They inhabit the oxic/anoxic interface within the upper few centimetres of sediment column, accumulating phosphate in their cells under oxic conditions and releasing it rapidly when conditions become anoxic. Sulphur bacteria are known to live in close association with a consortium of anaerobic methane oxidising archaea and syntrophic sulphate-reducing bacteria. Paleoproterozoic, c. 2.0 Ga Zaonega Formation in Karelia, Russia contains several P-rich intervals in the upper part of 1500 m thick succession of organic-rich sedimentary rocks interlayered with mafic tuffs and lavas. Apatite in these P-rich intervals forms impure laminae, lenses and round-oval nodules which diameters typically range from 300 to 1000 μm. Individual apatite particles in P-rich laminae and nodules commonly occur as cylinders that are 1-8 μm long and have diameters of 0.5-4 μm. Cross-sections of best preserved cylindrical apatite particles reveal a thin outer rim whereas the internal parts consist of small anhedral elongated crystallites, intergrown with carbonaceous material. During recrystallization the outer rim thickens towards interior and cylinders may attain hexagonal crystal habit, but their size and shape remains largely unchanged [2]. The sizes of Zaonega nodules are similar to giant sulphide-oxidising bacteria known from modern and ancient settings [3, 4]. Individual apatite cylinders and aggregates have shapes and sizes similar to the methanotrophic archaea that inhabit microbial mats in modern seep/vent areas where they operate in close associations with sulphur-oxidising microbial communities [5]. Seep/vent influence during the Zaonega phosphogenesis is indicated by variable, though positive Eu anomaly, expected in magmatically active sedimentary environment experiencing several lava flows

  14. THE ROLE AND THE TECHNIQUES USED BY THE MEDIATOR IN THE MEDIATION PROCESS

    Directory of Open Access Journals (Sweden)

    SEPTIMIU STOICA

    2011-04-01

    Full Text Available The present work aims to emphasize the complexity of the mediator’s activity during the mediation process, as an extra – judicial alternative dispute resolution methodology. Different mediation schools have launched different mediation models in terms of theoretical and practical approach of the matter. So one can note on brief the facilitative, the evaluative, the transformative and the narrative mediation, for example. It is not our goal to praise one of the above mentioned paradigms or to suggest a hierarchy among them. We think that each of these models is valuable and has a potential utility. The most important achievement is to solve the conflicts and to obtain the parties’ agreements, based on mediation generated solutions. It seems in this respect that different mediation models fit differently in solving specific cases. To reach the solutions of their conflict, the parties have to follow the mediator through a difficult and complicated route. It can be made easier by the mediator himself if he adapts his role and techniques according to the specifics of the parties and of the case. We assume that he can be more efficient if he will use a proper role from an appropriate model for a definite and concrete conflict or type of conflict. Even he may try to play a multiple role, changing its characteristics dynamically as the mediation process flows. The present work identifies some of the key roles that can be played by the mediator during the mediation process. Only based on these we can select, explain and analyze the specific or common techniques used by a mediator. Our point is that for his new case the efficient mediator must be flexible, knowledgeable and able to decide, select and perform a dedicated role or roles, same time or successively, and accordingly and dynamically use the adequate mediation techniques, which will be also summarized.

  15. Cleanup of contaminated areas

    International Nuclear Information System (INIS)

    The paper deals with the problem of contaminated areas cleanup, in order to eliminate every possible damage for man safety and environment and to site recovery for some utilization, The first step of cleanup operation is site characterization, that is followed by a pianificazion activity for a better definition of staff qualification, technology to be used, protection and prevention instruments for the risks due to contaminants handling. The second section describes the different remedial technologies for contaminated sites. Remedial technologies may be divided into on-site/off-site and in-situ treatments, according to whether materials (waste, soil, water) are moved to another location or not, respectively. Finally, it is outlined that contaminated areas cleanup is a typical multidisciplinary activity because very different competences are required. (author)

  16. Geoconservation and protected areas

    OpenAIRE

    Brilha, J. B.

    2002-01-01

    Conservation will fail if nature conservation policies impose artificial boundaries on the natural world. The protected area manager’s main task is biodiversity preservation. Nevertheless, nature conservation requires a broad perspective. Incorporating geology into conservation policies at the same level as biology is urgent. The slow rate of many geological processes leads to the misconception that geological resources are inexhaustible and immutable. Geologists know that this is not true an...

  17. Research Areas in Literature

    OpenAIRE

    Dr. S. T. Waghmode

    2012-01-01

    Research is the most distinguished activity that enhances the quality of higher-education. A person obsessed with research has to face many problems. Apart from having an appropriate guide, the real problem begins with the selection of the research topic. The vast and gleaming research area is always changing its dimensions. Some well-set, readymade and stereotyped topics do not attract the attention of a competent researcher, because he or she is always looking for what is new and qualitativ...

  18. Towards the Natural Gauge Mediation

    CERN Document Server

    Ding, Ran; Wang, Liucheng; Zhu, Bin

    2015-01-01

    The sweet spot supersymmetry (SUSY) solves the mu problem in the Minimal Supersymmetric Standard Model (MSSM) with gauge mediated SUSY breaking (GMSB) via the generalized Giudice-Masiero (GM) mechanism where only the mu-term and soft Higgs masses are generated at the unification scale of the Grand Unified Theory (GUT) due to the approximate PQ symmetry. Because all the other SUSY breaking soft terms are generated via the GMSB below the GUT scale, there exists SUSY electroweak (EW) fine-tuning problem to explain the 125 GeV Higgs boson mass due to small trilinear soft term. Thus, to explain the Higgs boson mass, we propose the GMSB with both the generalized GM mechanism and Higgs-messenger interactions. The renormalization group equations are runnings from the GUT scale down to EW scale. So the EW symmetry breaking can be realized easier. We can keep the gauge coupling unification and solution to the flavor problem in the GMSB, as well as solve the \\mu/B_{\\mu}-problem. Moreover, there are only five free parame...

  19. Protease-mediated drug delivery

    Science.gov (United States)

    Dickson, Eva F.; Goyan, Rebecca L.; Kennedy, James C.; Mackay, M.; Mendes, M. A. K.; Pottier, Roy H.

    2003-12-01

    Drugs used in disease treatment can cause damage to both malignant and normal tissue. This toxicity limits the maximum therapeutic dose. Drug targeting is of high interest to increase the therapeutic efficacy of the drug without increasing systemic toxicity. Certain tissue abnormalities, disease processes, cancers, and infections are characterized by high levels of activity of specific extracellular and/or intracellular proteases. Abnormally high activity levels of specific proteases are present at sites of physical or chemical trauma, blood clots, malignant tumors, rheumatoid arthritis, inflammatory bowel disease, gingival disease, glomerulonerphritis, and acute pancreatitis. Abnormal protease activity is suspected in development of liver thrombosis, pulmonary emphysema, atherosclerosis, and muscular dystrophy. Inactiviating disease-associated proteases by the administration of appropriate protease inhibitors has had limited success. Instead, one could use such proteases to target drugs to treat the condition. Protease mediated drug delivery offers such a possibility. Solubilizing groups are attached to insoluble drugs via a polypeptide chain which is specifically cleavable by certian proteases. When the solubilized drug enounters the protease, the solubilizing moieties are cleaved, and the drug precipitates at the disease location. Thus, a smaller systemic dosage could result in a therapeutic drug concentration at the treatment site with less systemic toxicity.

  20. Nucleotide-mediated airway clearance.

    Science.gov (United States)

    Schmid, Andreas; Clunes, Lucy A; Salathe, Mathias; Verdugo, Pedro; Dietl, Paul; Davis, C William; Tarran, Robert

    2011-01-01

    A thin layer of airway surface liquid (ASL) lines the entire surface of the lung and is the first point of contact between the lung and the environment. Surfactants contained within this layer are secreted in the alveolar region and are required to maintain a low surface tension and to prevent alveolar collapse. Mucins are secreted into the ASL throughout the respiratory tract and serve to intercept inhaled pathogens, allergens and toxins. Their removal by mucociliary clearance (MCC) is facilitated by cilia beating and hydration of the ASL by active ion transport. Throughout the lung, secretion, ion transport and cilia beating are under purinergic control. Pulmonary epithelia release ATP into the ASL which acts in an autocrine fashion on P2Y(2) (ATP) receptors. The enzymatic network describes in Chap. 2 then mounts a secondary wave of signaling by surface conversion of ATP into adenosine (ADO), which induces A(2B) (ADO) receptor-mediated responses. This chapter offers a comprehensive description of MCC and the extensive ramifications of the purinergic signaling network on pulmonary surfaces. PMID:21560046

  1. Gauge mediation with light stops

    CERN Document Server

    Delgado, Antonio; Quiros, Mariano

    2015-01-01

    The mechanism of gauge mediated supersymmetry breaking (GMSB) solves the supersymmetric flavor problem although it requires superheavy stops to reproduce the experimental value (125 GeV) of the Higgs mass. A possible way out is to extend the MSSM Higgs sector with triplets which provide extra tree-level corrections to the Higgs mass. Triplets with neutral components getting vacuum expectation values (VEV) have the problem of generating a tree-level correction to the \\rho parameter. We introduce supersymmetric triplets with hypercharges Y=(0,\\pm 1), with a tree-level custodial SU(2)_L\\otimes SU(2)_R global symmetry in the Higgs sector protecting the \\rho parameter: a supersymmetric generalization of the Georgi-Machacek model. The renormalization group running from the messenger to the electroweak scale mildly breaks the custodial symmetry. We will present realistic low-scale scenarios, their main features being a Bino-like neutralino or right-handed stau as the NLSP, light (1 TeV) stops, exotic couplings (H^\\p...

  2. High surface area calcite

    Science.gov (United States)

    Schultz, L. N.; Andersson, M. P.; Dalby, K. N.; Müter, D.; Okhrimenko, D. V.; Fordsmand, H.; Stipp, S. L. S.

    2013-05-01

    Calcite (CaCO3) is important in many fields—in nature, because it is a component of aquifers, oil reservoirs and prospective CO2 storage sites, and in industry, where it is used in products as diverse as paper, toothpaste, paint, plastic and aspirin. It is difficult to obtain high purity calcite with a high surface area but such material is necessary for industrial applications and for fundamental calcite research. Commercial powder is nearly always contaminated with growth inhibitors such as sugars, citrate or pectin and most laboratory synthesis methods deliver large precipitates, often containing vaterite or aragonite. To address this problem, we (i) adapted the method of carbonating a Ca(OH)2 slurry with CO2 gas to develop the first simple, cheap, safe and reproducible procedure using common laboratory equipment, to obtain calcite that reproducibly had a surface area of 14-17 m2/g and (ii) conducted a thorough characterization of the product. Scanning electron microscopy (SEM) revealed nanometer scale, rhombohedral crystals. X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and infrared spectroscopy (IR) confirmed highly crystalline, pure calcite that more closely resembles the dimensions of the biogenic calcite produced by algae in coccoliths than other methods for synthesizing calcite. We suggest that this calcite is useful when purity and high surface area are important.

  3. Frostbites in circumpolar areas

    Directory of Open Access Journals (Sweden)

    Tiina Maria Ikäheimo

    2011-10-01

    Full Text Available Circumpolar areas are associated with prolonged cold exposure where wind, precipitation, and darkness further aggravate the environmental conditions and the associated risks. Despite the climate warming, cold climatic conditions will prevail in circumpolar areas and contribute to adverse health effects. Frostbite is a freezing injury where localized damage affects the skin and other tissues. It occurs during occupational or leisure-time activities and is common in the general population among men and women of various ages. Industries of the circumpolar areas where frostbite occurs frequently include transportation, mining, oil, and gas industry, construction, agriculture, and military operations. Cold injuries may also occur during leisure-time activities involving substantial cold exposure, such as mountaineering, skiing, and snowmobiling. Accidental situations (occupational, leisure time often contribute to adverse cooling and cold injuries. Several environmental (temperature, wind, wetness, cold objects, and altitude and individual (behavior, health, and physiology predisposing factors are connected with frostbite injuries. Vulnerable populations include those having a chronic disease (cardiovascular, diabetes, and depression, children and the elderly, or homeless people. Frostbite results in sequelae causing different types of discomfort and functional limitations that may persist for years. A frostbite injury is preventable, and hence, unacceptable from a public health perspective. Appropriate cold risk management includes awareness of the adverse effects of cold, individual adjustment of cold exposure and clothing, or in occupational context different organizational and technical measures. In addition, vulnerable population groups need customized information and care for proper prevention of frostbites.

  4. Motion-induced blindness and Troxler fading: common and different mechanisms

    NARCIS (Netherlands)

    Y.S. Bonneh; T.H. Donner; A. Cooperman; D.J. Heeger; D. Sagi

    2014-01-01

    Extended stabilization of gaze leads to disappearance of dim visual targets presented peripherally. This phenomenon, known as Troxler fading, is thought to result from neuronal adaptation. Intense targets also disappear intermittently when surrounded by a moving pattern (the "mask"), a phenomenon kn

  5. Measuring Motion-Induced B0-Fluctuations in the Brain Using Field Probes

    DEFF Research Database (Denmark)

    Andersen, Mads; Hanson, Lars G.; Madsen, Kristoffer H.;

    2016-01-01

    Purpose: Fluctuations of the background magnetic field (B0) due to body and breathing motion can lead to significant artifacts in brain imaging at ultrahigh field. Corrections based on real-time sensing using external field probes show great potential. This study evaluates different aspects of fi...

  6. DNA motion induced by electrokinetic flow near an Au coated nanopore surface as voltage controlled gate

    International Nuclear Information System (INIS)

    We used fluorescence microscopy to investigate the diffusion and drift motion of λ DNA molecules on an Au-coated membrane surface near nanopores, prior to their translocation through solid-state nanopores. With the capability of controlling electric potential at the Au surface as a gate voltage, Vgate, the motions of DNA molecules, which are presumably generated by electrokinetic flow, vary dramatically near the nanopores in our observations. We carefully investigate these DNA motions with different values of Vgate in order to alter the densities and polarities of the counterions, which are expected to change the flow speed or direction, respectively. Depending on Vgate, our observations have revealed the critical distance from a nanopore for DNA molecules to be attracted or repelled—DNA’s anisotropic and unsteady drifting motions and accumulations of DNA molecules near the nanopore entrance. Further finite element method (FEM) numerical simulations indicate that the electrokinetic flow could qualitatively explain these unusual DNA motions near metal-collated gated nanopores. Finally, we demonstrate the possibility of controlling the speed and direction of DNA motion near or through a nanopore, as in the case of recapturing a single DNA molecule multiple times with alternating current voltages on the Vgate. (paper)

  7. Motion induced passenger dislocations in life raft and life boat configurations

    NARCIS (Netherlands)

    Bos, J.E.; Andersen ,O.; Reinke, P.

    2010-01-01

    Within the European project SafeCrafts, dealing with the safe abandoning of ships, the dislocation of passengers aboard life boats and rafts has been considered to be a risk regarding passenger survival at sea. To get an idea about the risks and the affecting factors involved, we studied the effects

  8. Transition between locked and running states for dimer motion induced by periodic external driving.

    Science.gov (United States)

    Hennig, D; Martens, S; Fugmann, S

    2008-07-01

    We study the motion of a dimer in a one-dimensional spatially periodic washboard potential. The tilt of the latter is time-periodically modulated by an ac field. We focus interest on the detrapping of the (static) ground state solution of the dimer caused by the ac field. Moreover, we demonstrate that slow tilt modulations not only induce a trapping-detrapping transition but drive the dimer dynamics into a regime of transient long-range running states. Most strikingly, the motion proceeds then unidirectionally, so that the dimer covers huge distances regardless of the fact that the bias force in the driven system vanishes on the average. We elucidate the underlying dynamics in phase space and associate long-lasting running states with the motion in ballistic channels occurring due to stickiness to invariant tori. PMID:18763916

  9. Fuel motion induced by a sharp burst TUCOP: PFR/TREAT test L07

    International Nuclear Information System (INIS)

    In the transient-undercooling-driven overpower (TUCOP) accident scenario for moderate-to-high-sodium-void-worth-LMFBR cores, some computer codes predict large reactivity increases caused by compactive in-pin fuel motion in low power subassemblies during a power burst resulting from sodium voiding in the lead fuel subassemblies. In this hypothetical scenario, the low power subassemblies are predicted to experience midplane failure with relatively cold cladding, which inhibits radial dispersal and results in a momentary accumulation of fuel around the midplane failure site. A major objective of PFR/TREAT Test L07 was to simulate such low-power-subassembly TUCOP conditions, measure the associated fuel motion and evaluate the fuel-motion predictions

  10. Soliton-like magnetic domain wall motion induced by the interfacial Dzyaloshinskii-Moriya interaction

    Science.gov (United States)

    Ono, Teruo

    Topological defects such as magnetic solitons, vortices, Bloch lines, and skyrmions start to play an important role in modern magnetism due to their extraordinary stability which can be hailed as future memory devices. Recently, novel type of antisymmetric exchange interaction, namely the Dzyaloshinskii-Moriya interaction (DMI), has been uncovered and found to influence on the formation of topological defects. Exploring how the DMI affects the dynamics of topological defects is therefore an important task. Here we investigate the dynamics of the magnetic domain wall (DW) under a DMI by developing a time-of-flight measurement scheme which allows us to measure the DW velocity for magnetic fields up to 0.3T. For a weak DMI, the trend of DW velocity follows the Walker's model which predicts that the velocity of DW increases with field up to a threshold (Walker field) and decreases abruptly. On the other hand, for a strong DMI, velocity breakdown is completely suppressed and the DW keeps its maximum velocity even far above the Walker field. Such a distinct trend of the DW velocity, which has never been predicted, can be explained in terms of magnetic soliton, of which topology can be protected by the DMI. Importantly, such a soliton-like DW motion is only observed in two dimensional systems, implying that the vertical Bloch lines (VBLs) creating inside of the magnetic domain-wall play a crucial role. This work was partly supported by JSPS KAKENHI Grant Numbers 15H05702, 26870300, 26870304, 26103002, 25.4251, Collaborative Research Program of the Institute for Chemical Research, Kyoto University, and R & D Project for ICT Key Technology of MEXT from the Japan Society for the Promotion of Science (JSPS).

  11. Repetitive arm motion-induced fatigue affects shoulder but not endpoint position sense.

    Science.gov (United States)

    Emery, Kim; Côté, Julie N

    2012-02-01

    Neck/shoulder pain has previously been linked to repetitive work and muscle fatigue. We have shown that asymptomatic people performing repetitive upper limb tasks display signs of shoulder fatigue and of whole-body compensatory strategies. However, the role played by the proprioceptive system in the production of these compensatory strategies has not been studied. A group of asymptomatic adults (n = 18) performed a repetitive pointing task at shoulder height to fatigue. Before and after fatigue, they performed two position sense tasks, eyes closed: a single-joint task where they abducted their shoulder to the perceived horizontal and a multi-joint task, where they stood and placed their finger at the perceived location of a target in front of them at shoulder height. After fatigue, subjects made larger shoulder errors by raising their elbow higher above the horizontal (~ +1.3 cm) than before fatigue; however, their finger position accuracy was not changed, despite all subjects performing the movement in less time (~ -0.18 s) while fatigued. There were no gender differences in shoulder or finger position accuracy before or after fatigue; however, there were gender differences in the perceived finger-target location and in the temporal characteristics of the finger movement toward the target. Results suggest that healthy individuals are able to develop strategies to compensate for fatigue-induced deficits at one joint to maintain the endpoint accuracy of a multi-joint task constant. Gender differences in movement strategies and perception of endpoint location may play parts in the previously reported gender differences in work-related neck/shoulder symptoms. PMID:22124803

  12. Motor equivalence and self-motion induced by different movement speeds

    OpenAIRE

    Scholz, J. P.; Dwight-Higgin, T.; Lynch, J. E.; Tseng, Y. W.; Martin, V.; Schöner, G.

    2011-01-01

    This study investigated pointing movements in 3D asking two questions: (1) Is goal-directed reaching accompanied by self-motion, a component of the joint velocity vector that leaves the hand’s movement unaffected? (2) Are differences in the terminal joint configurations among different speeds of reaching motor equivalent (i.e., terminal joint configurations differ more in directions of joint space that do not produce different pointer-tip positions than in directions that do) or non-motor equ...

  13. Mediators as the Walrasian Auctioneers of Exchange Theory

    OpenAIRE

    Dickenson, David

    2003-01-01

    This article opens up mediation to systematic economic analysis by considering mediators as analogous to the Walrasian auctioneers of exchange theory. By altering trade-off rates among bargaining issues, mediators facilitate a process leading towards Pareto efficient voluntary settlements.

  14. 76 FR 19310 - Information Collection; Certified State Mediation Program

    Science.gov (United States)

    2011-04-07

    ... Farm Service Agency Information Collection; Certified State Mediation Program AGENCY: Farm Service... Mediation Program. The information collection is necessary to ensure the grant program is being administered... following methods: Mail: Carol Wagner, Certified State Mediation Program Manager, USDA, FSA, Appeals...

  15. Estimation of Mediation Effects for Zero-inflated Regression Models

    OpenAIRE

    Wang, Wei; Albert, Jeffrey M.

    2012-01-01

    The goal of mediation analysis is to identify and explicate the mechanism that underlies a relationship between a risk factor and an outcome via an intermediate variable (mediator). In this paper, we consider the estimation of mediation effects in zero-inflated (ZI) models intended to accommodate `extra' zeros in count data. Focusing on the ZI negative binomial (ZINB) models, we provide a mediation formula approach to estimate the (overall) mediation effect in the standard two-stage mediation...

  16. REGULATION OF INSURANCE MEDIATION IN CONDITIONS OF EURO INTEGRATION PROCESSES OF UKRAINE

    Directory of Open Access Journals (Sweden)

    A. Sholoiko

    2016-05-01

    Full Text Available The review of national and European legislation in the field of regulation of insurance mediation is made. Subjects and object of regulation of insurance mediation are defined. The order of the legislative approximation in conditions of changing legislation of regulation of insurance mediation in European Union is characterized. A comparison of legal provisions to regulate insurance mediation in Ukraine and the EU is done. Suggestions of adaptation national legislation to the European in the area of regulation of insurance mediation in conditions of euro integration processes are represented. The main are the next: - it is advisable to expand the object and the scope of regulation of insurance mediation and set appropriate limits to the subjects for which the sale of insurance products is not the main activity; - it is necessary to introduce a regular improvement of the knowledge and skills for insurance distributors because of the development of insurance conditions and changing of economic environment; - it is necessary to create the order of compulsory professional indemnity insurance in accordance with the requirements of the Directive on insurance distribution; - before the signing of the contract it is necessary to disclosure to customers of insurance products the information about the status of insurance distributors and type of remuneration that they receive; - if the insurance product is in addition to the goods or services, insurance distributor shall inform the client about the possibility of buying various product components separately with the presentation of their characteristics.

  17. Current rectification by mediating electroactive polymers

    International Nuclear Information System (INIS)

    In this work we briefly review the theoretical basis for the electrochemical rectification in mediated redox reactions at redox polymer modified electrodes. Electrochemical rectification may have two distinct origins. It is either caused by a slow kinetics of the reaction between the external redox couple and the mediator or it is originated by a slow electronic transport within the film under an unfavorable thermodynamic condition. We show experimental results for the redox mediation reaction of poly(o-aminophenol) (POAP) on the Fe2+/3+ and on the Fe(CN)63-/4- redox couples in solution that prove the proposed mechanisms of electrochemical rectification

  18. Singlet deflected anomaly/gauge mediation

    International Nuclear Information System (INIS)

    We study an extension of the standard anomaly/gauge mediation scenario where the messenger fields have direct interactions with an extra gauge singlet. This realizes a phenomenologically viable NMSSM-like scenario free of the μ-bμ problem. Current cosmological constraints imply a small size for the anomaly-mediation contributions, unless some source of R-parity violation is permitted. In the latter case the allowed regions in the parameter space can be substantially larger than in the corresponding gauge-mediation scenario.

  19. Hybrid anomaly-gravity mediation with flavor

    International Nuclear Information System (INIS)

    We study models with contributions of similar size to the soft masses from anomaly-and gravity mediation, thereby curing the tachyonic slepton problem of anomaly mediation. A possible origin of this hybrid setup in a 5-dimensional brane world is briefly discussed. The absence of excessive flavor violation is explained by alignment. The gravitino can be heavy enough so that the gravitino problem of supersymmetric theories with leptogenesis is avoided. The model has a characteristic signature: It predicts the distinctive gaugino mass pattern of anomaly mediation and, at the same time, O(1) slepton mass splittings.

  20. Energy National Mediator activity report 2009

    International Nuclear Information System (INIS)

    After some data illustrating the activity of the Energy National Mediator in 2009, and an interview of a representative of this institution who comments its practice, this report proposes the opinions of the different involved actors (communities, consumer associations, providers, and so on) about the mediator. It puts the adopted strategy in perspective from the past year to the coming one. It describes the missions: information, advice, protection. It reports actions, recommendations and facts for 2009 in terms of consumer information, group mediation, poverty management, samples of analysed disputes. It presents the social organisation and gives a financial assessment of the institution

  1. Effect of stimulus size and luminance on the rod-, cone-, and melanopsin-mediated pupillary light reflex.

    Science.gov (United States)

    Park, Jason C; McAnany, J Jason

    2015-01-01

    This study determined if the pupillary light reflex (PLR) driven by brief stimulus presentations can be accounted for by the product of stimulus luminance and area (i.e., corneal flux density, CFD) under conditions biased toward the rod, cone, and melanopsin pathways. Five visually normal subjects participated in the study. Stimuli consisted of 1-s short- and long-wavelength flashes that spanned a large range of luminance and angular subtense. The stimuli were presented in the central visual field in the dark (rod and melanopsin conditions) and against a rod-suppressing short-wavelength background (cone condition). Rod- and cone-mediated PLRs were measured at the maximum constriction after stimulus onset whereas the melanopsin-mediated PLR was measured 5-7 s after stimulus offset. The rod- and melanopsin-mediated PLRs were well accounted for by CFD, such that doubling the stimulus luminance had the same effect on the PLR as doubling the stimulus area. Melanopsin-mediated PLRs were elicited only by short-wavelength, large (>16°) stimuli with luminance greater than 10 cd/m(2), but when present, the melanopsin-mediated PLR was well accounted for by CFD. In contrast, CFD could not account for the cone-mediated PLR because the PLR was approximately independent of stimulus size but strongly dependent on stimulus luminance. These findings highlight important differences in how stimulus luminance and size combine to govern the PLR elicited by brief flashes under rod-, cone-, and melanopsin-mediated conditions. PMID:25788707

  2. Small Area Fair Market Rent

    Data.gov (United States)

    Department of Housing and Urban Development — Due to the increasing demand for more localized rents for a variety of purposes, HUD is making Small Area FMRs for all metropolitan areas available. Small Area FMRs...

  3. CELLULAR INTERACTIONS MEDIATED BY GLYCONECTIDS

    Directory of Open Access Journals (Sweden)

    O.Popescu

    1999-01-01

    Full Text Available Cellular interactions involve many types of cell surface molecules and operate via homophilic and/or heterophilic protein-protein and protein-carbohydrate binding. Our investigations in different model-systems (marine invertebrates and mammals have provided direct evidence that a novel class of primordial proteoglycans, named by us gliconectins, can mediate cell adhesion via a new alternative molecular mechanism of polyvalent carbohydrate-carbohydrate binding. Biochemical characterization of isolated and purified glyconectins revealed the presence of specific carbohydrate structures, acidic glycans, different from classical glycosaminoglycans. Such acidic glycans of high molecular weight containing fucose, glucuronic or galacturonic acids, and sulfate groups, originally found in sponges and sea urchin embryos, may represent a new class of carbohydrate carcino-embryonal antigens in mice and humans. Such interactions between biological macromolecules are usually investigated by kinetic binding studies, calorimetric methods, X-ray diffraction, nuclear magnetic resonance, and other spectroscopic analyses. However, these methods do not supply a direct estimation of the intermolecular binding forces that are fundamental for the function of the ligand-receptor association. Recently, we have introduced atomic force microscopy to quantify the binding strength between cell adhesion proteoglycans. Measurement of binding forces intrinsic to cell adhesion proteoglycans is necessary to assess their contribution to the maintenance of the anatomical integrity of multicellular organisms. As a model, we selected the glyconectin 1, a cell adhesion proteoglycan isolated from the marine sponge Microciona prolifera. This glyconectin mediates in vivo cell recognition and aggregation via homophilic, species-specific, polyvalent, and calcium ion-dependent carbohydrate-carbohydrate interactions. Under physiological conditions, an adhesive force of up to 400 piconewtons

  4. Selective Area Band Engineering of Graphene using Cobalt-Mediated Oxidation

    OpenAIRE

    Paul F. Bazylewski; Luan Nguyen; Robert P.C. Bauer; Hunt, Adrian H.; Eamon J. G. McDermott; Leedahl, Brett D.; Andrey I. Kukharenko; Cholakh, Seif O.; Kurmaev, Ernst Z.; Peter Blaha; Alexander Moewes; Young Hee Lee; Gap Soo Chang

    2015-01-01

    This study reports a scalable and economical method to open a band gap in single layer graphene by deposition of cobalt metal on its surface using physical vapor deposition in high vacuum. At low cobalt thickness, clusters form at impurity sites on the graphene without etching or damaging the graphene. When exposed to oxygen at room temperature, oxygen functional groups form in proportion to the cobalt thickness that modify the graphene band structure. Cobalt/Graphene resulting from this trea...

  5. Fuel Cell Platinum Catalysts Supported on Mediate Surface Area Carbon Black Supports

    Czech Academy of Sciences Publication Activity Database

    Kaluža, Luděk; Larsen, M.J.; Zdražil, Miroslav; Gulková, Daniela; Odgaard, M.

    2015-01-01

    Roč. 43, č. 2015 (2015), s. 913-918. ISSN 1974-9791. [International Conference on Chemical and Process Engineering - ICheaP12 /12./. Milano, 19.05.2015-22.05.2015] R&D Projects: GA MŠk(CZ) 7HX13003 EU Projects: European Commission(XE) 303466 - IMMEDIATE Institutional support: RVO:67985858 Keywords : carbon black * platinum catalyst * fuel cell Subject RIV: CI - Industrial Chemistry, Chemical Engineering

  6. Dementia in Taiwan area

    Institute of Scientific and Technical Information of China (English)

    Yuanhan Yang

    2016-01-01

    Objective:Taiwan has an increasing aging population like other developed areas. The aging population will lead to an increased prevalence of dementia. Methods:This article will reflect the status of dementia in Taiwan, including updated epidemiology, diagnosis, subtypes, and optimal treatment of dementia. Results:The article also describes and interprets the Taiwan Dementia Policy to establish a clear, large view of the current state of management of dementia in Taiwan and future policy implementation. Conclusion:A comprehensive policy to dementia, from the basic researches to clinical care and treatment, is necessary to the increased aged population in Taiwan.

  7. Dark matter prospects in deflected mirage mediation

    Energy Technology Data Exchange (ETDEWEB)

    Holmes, Michael; Nelson, Brent D., E-mail: holmes.mi@neu.edu, E-mail: b.nelson@neu.edu [Department of Physics, Northeastern University, Boston, MA 02115 (United States)

    2009-07-01

    The recently introduced deflected mirage mediation (DMM) model is a string-motivated paradigm in which all three of the major supersymmetry-breaking transmission mechanisms are operative. We begin a systematic exploration of the parameter space of this rich model context, paying special attention to the pattern of gaugino masses which arise. In this work we focus on the dark matter phenomenology of the DMM model as such signals are the least influenced by the model-dependent scalar masses. We find that a large portion of the parameter space in which the three mediation mechanisms have a similar effective mass scale of 1 TeV or less will be probed by future direct and indirect detection experiments. Distinguishing deflected mirage mediation from the mirage model without gauge mediation will prove difficult without collider input, though we indicate how gamma ray signals may provide an opportunity for distinguishing between the two paradigms.

  8. Dark Matter Prospects in Deflected Mirage Mediation

    CERN Document Server

    Holmes, Michael

    2009-01-01

    The recently introduced deflected mirage mediation (DMM) model is a string-motivated paradigm in which all three of the major supersymmetry-breaking transmission mechanisms are operative. We begin a systematic exploration of the parameter space of this rich model context, paying special attention to the pattern of gaugino masses which arise. In this work we focus on the dark matter phenomenology of the DMM model as such signals are the least influenced by the model-dependent scalar masses. We find that a large portion of the parameter space in which the three mediation mechanisms have a similar effective mass scale of 1 TeV or less will be probed by future direct and indirect detection experiments. Distinguishing deflected mirage mediation from the mirage model without gauge mediation will prove difficult without collider input, though we indicate how gamma ray signals may provide an opportunity for distinguishing between the two paradigms.

  9. BRIEF CONSIDERATIONS REGARDING MEDIATION IN CRIMINAL MATTERS

    Directory of Open Access Journals (Sweden)

    LUMINITA DRAGNE

    2012-05-01

    Full Text Available Mediation is an alternative means of conflict resolution, is designed as a flexible procedure whose utility was observed in contrast to the deficiencies of the judiciary system. In the field of criminal law, mediation is part of the larger concept of the restorative justice whose aim is restoring the main victim in its rights. From this perspective, to the criminal process is intended, in principal, repairing of the victim's prejudice and, subsequently, to encourage the delinquent in taking responsibility and to acknowledge his guilt, and also to determine him to actively participate in repairing the damage caused. The ultimate goal of the process is giving back the delinquent to society and consequently, reducing the relapse. Romanian legislator has not taken this concept, and how it is regulated mediation in criminal matters is hesitant, cautious and ultimately ineffective. Specifically, in situations that will actually occur, victim-delinquent mediation will only take the form of "assisted reconciliation."

  10. Molecular biology Mediating transcription and RNA export

    Science.gov (United States)

    Rubin, Jonathan D.; Taatjes, Dylan J.

    2016-01-01

    The finding that the Mediator protein complex contributes to messenger RNA export from the nucleus in yeast adds to a growing list of roles for the complex in regulating transcriptional processes. PMID:26450052

  11. Orm family proteins mediate sphingolipid homeostasis

    DEFF Research Database (Denmark)

    Breslow, David K; Collins, Sean R; Bodenmiller, Bernd;

    2010-01-01

    expression or mutations to their phosphorylation sites cause dysregulation of sphingolipid metabolism. Our work identifies the Orm proteins as critical mediators of sphingolipid homeostasis and raises the possibility that sphingolipid misregulation contributes to the development of childhood asthma....

  12. Dark matter prospects in deflected mirage mediation

    International Nuclear Information System (INIS)

    The recently introduced deflected mirage mediation (DMM) model is a string-motivated paradigm in which all three of the major supersymmetry-breaking transmission mechanisms are operative. We begin a systematic exploration of the parameter space of this rich model context, paying special attention to the pattern of gaugino masses which arise. In this work we focus on the dark matter phenomenology of the DMM model as such signals are the least influenced by the model-dependent scalar masses. We find that a large portion of the parameter space in which the three mediation mechanisms have a similar effective mass scale of 1 TeV or less will be probed by future direct and indirect detection experiments. Distinguishing deflected mirage mediation from the mirage model without gauge mediation will prove difficult without collider input, though we indicate how gamma ray signals may provide an opportunity for distinguishing between the two paradigms

  13. Cybercultures mediations of community, culture, politics

    CERN Document Server

    Harris, Breslow

    2012-01-01

    Cybercultures: Mediations of Community, Culture, Politics , is a collection of essays that critically examine the role that digital media and online cultures play in the rearticulation of contemporary societies, cultures and polities. This volume in

  14. Programmable DNA-mediated multitasking processor

    CERN Document Server

    Shu, Jian-Jun; Yong, Kian-Yan; Shao, Fangwei; Lee, Kee Jin

    2015-01-01

    Because of DNA appealing features as perfect material, including minuscule size, defined structural repeat and rigidity, programmable DNA-mediated processing is a promising computing paradigm, which employs DNAs as information storing and processing substrates to tackle the computational problems. The massive parallelism of DNA hybridization exhibits transcendent potential to improve multitasking capabilities and yield a tremendous speed-up over the conventional electronic processors with stepwise signal cascade. As an example of multitasking capability, we present an in vitro programmable DNA-mediated optimal route planning processor as a functional unit embedded in contemporary navigation systems. The novel programmable DNA-mediated processor has several advantages over the existing silicon-mediated methods, such as conducting massive data storage and simultaneous processing via much fewer materials than conventional silicon devices.

  15. Genesis and intersubjectivity: levels of mediation.

    Science.gov (United States)

    Yamamoto, Toshiya

    2012-09-01

    I will make a brief comment on the thesis of José C. Loredo-Narciandi and José C. Sánchez-González (2012) "Neither Dichotomies Nor Dualism; Simply Genesis". Denying any reductionism and reification, they insists the importance of inseparable relation between subject and object, then discuss about genesis. I pointed out that their argument lacks an important element, i.e., mediator that differ from mere physical object. After discussing mediators nature, I discriminate the three level of interaction which mediated by mediator. The first is the pre-interaction level, the second is physical interaction level and the third is sign or language interaction level. The last argument of mine is about how we can solve the problem of reification and reductionism. In the argument it is pointed out that intersubjectivity is key concept for understanding and solving the problem appropriately. PMID:22628155

  16. Cultural Influences on Mediation in International Crises

    OpenAIRE

    Molly Inman; Roudabeh Kishi; Jonathan Wilkenfeld; Michele Gelfand; Elizabeth Salmon

    2014-01-01

    In order to assess the impact of culture on state behavior in international crises, specifically with regard to mediation and its outcome, this study tests hypotheses rooted in both the international relations and the cross-cultural psychology literatures, implementing analysis at both the international-system level and the domestic-state-actor level. At the international system level, the study finds that cultural difference between adversaries affects whether or not mediation occurs during ...

  17. Antibody-Mediated Lung Transplant Rejection

    OpenAIRE

    Hachem, Ramsey

    2012-01-01

    Antibody-mediated rejection after lung transplantation remains enigmatic. However, emerging evidence over the past several years suggests that humoral immunity plays an important role in allograft rejection. Indeed, the development of donor-specific antibodies after transplantation has been identified as an independent risk factor for acute cellular rejection and bronchiolitis obliterans syndrome. Furthermore, cases of acute antibody-mediated rejection resulting in severe allograft dysfunctio...

  18. Immunogenetic markers in immune mediated diseases

    OpenAIRE

    Nikitina-Zake, Liene

    2003-01-01

    The aim of this thesis was to study HLA class II markers, as well as other - MHC and non MHC genes in different immune - mediated diseases, namely, cervical intraepithelial neoplasia (CIN), cervical cancer, juvenile idiopathic arthritis (JIA), mixed connective tissue disease (MCTD) and type I diabetes mellitus (T1 DM). HLA class II genes are located on the short arm of chromosome 6 and are known to be important for pathogenesis of immune - mediated diseases due to the fu...

  19. Criminal Mediation for Minors in Israel

    OpenAIRE

    Isack Kandel; Yael Arie; Sharon Glasner

    2007-01-01

    Mediation was introduced in Canada in 1974 in order to handle a crime of robbery and vandalization committed by adolescents. After mediation, these adolescents agreed to apologize to each of their victims and pay restitution. Several countries (Canada, England, Finland, and the U.S.) have now made this opportunity available in the cases of young offenders. This review describes the process in the south of Israel. We find this method very powerful, but further studies are needed. Due to resour...

  20. The Mediation of Power: A Criticial Introduction

    OpenAIRE

    Davis, Aeron

    2007-01-01

    The Mediation of Power investigates how those in positions of power use and are influenced by media in their everyday activities. Each chapter examines this theme through an exploration of some of the key topics and debates in the field, including theories of media and power, media policy and the economics of information, news production and journalistic practice, public relations and media management, culture and power, political communication and mediated politics, new and alternative media...

  1. Mediated Certificateless Signature without Random Oracles

    Directory of Open Access Journals (Sweden)

    Minghui Zheng

    2011-08-01

    Full Text Available It is worthwhile challenges to deal with the key escrow problem and key revocation in identity-based signatures. We first introduce the notion of security-mediated certificateless signature scheme and proves the scheme in the standard model. The mediated certificateless public key cryptography not only provides a fast revocation with fine granularity but also overcomes the key escrow property which exists in ID-based signature. The scheme is provably secure without random oracles.

  2. Developing the conversation about workplace mediation

    OpenAIRE

    Kenny, Teresa

    2014-01-01

    This article examines some of the latest writing and research in relation to conflict in work and workplace mediation. It considers three specific issues of size and sector of organisations, the attitude of organisations to conflict and the employee relations environment in organisations. It reviews the various views in relation to fundamental aspects of mediation such as the neutral third party, voluntarism, informality and confidentiality to inform thinking as well as practitioner and acade...

  3. Holographic realization of gauge mediated supersymmetry breaking

    CERN Document Server

    Skenderis, Kostas

    2012-01-01

    The general gauge mediation scenario provides a framework in which properties of a visible sector with soft supersymmetry breaking are computed from current correlation functions in the supersymmetry breaking hidden sector. In this paper we will use holography to model strongly coupled hidden sectors by weakly curved geometries and describe how the current correlators relevant for general gauge mediation are computed by holographic methods. We illustrate the general setup by a toy example which captures most of the relevant features.

  4. Singlet deflected anomaly/gauge mediation

    OpenAIRE

    de Blas, J.; Delgado, A

    2011-01-01

    We study an extension of the standard anomaly/gauge mediation scenario where the messenger fields have direct interactions with an extra gauge singlet. This realizes a phenomenologically viable NMSSM-like scenario free of the mu-b_mu problem. Current cosmological constraints imply a small size for the anomaly-mediation contributions, unless some source of R-parity violation is permitted. In the latter case the allowed regions in the parameter space can be substantially larger than in the corr...

  5. Yeast Oligo-mediated Genome Engineering (YOGE)

    OpenAIRE

    DiCarlo, JE; Conley, AJ; Penttilä, M; Jäntti, J; Wang, HH; Church, GM

    2013-01-01

    High-frequency oligonucleotide-directed recombination engineering (recombineering) has enabled rapid modification of several prokaryotic genomes to date. Here, we present a method for oligonucleotide-mediated recombineering in the model eukaryote and industrial production host S. cerevisiae, which we call Yeast Oligo-mediated Genome Engineering (YOGE). Through a combination of overexpression and knockouts of relevant genes and optimization of transformation and oligonucleotide designs, we ach...

  6. Mediated and Mobile Communication for Experts

    OpenAIRE

    Nilsson, Marcus

    2014-01-01

    This thesis focuses on systems for mediated communication that run on mobile technology. The aim has been to give an answer to the question about what require- ments there are for situation awareness for domain experts when communication is secondary and supports the primary task. This thesis originated in a critical approach to the common practice of design- ing mediated communication systems with the face-to-face meeting as a guiding scenario. Instead, this thesis explores a design process ...

  7. Mechanisms mediating cholinergic antral circular smooth muscle contraction in rats

    Institute of Scientific and Technical Information of China (English)

    Helena F Wrzos; Tarun Tandon; Ann Ouyang

    2004-01-01

    AIM: To investigate the pathway (s) mediating rat antral circular smooth muscle contractile responses to the cholinomimetic agent, bethanechol and the subtypes of muscarinic receptors mediating the cholinergic contraction.METHODS: Circular smooth muscle strips from the antrum of Sprague-Dawley rats were mounted in muscle baths in Krebs buffer. Isometric tension was recorded. Cumulative concentration-response curves were obtained for (+)-cisdioxolane (cD), a nonspecific muscarinic agonist, at 10-8-10-4 mol/L, in the presence of tetrodotoxin (TTX, 10-7 mol/L).Results were normalized to cross sectional area. A repeat concentration-response curve was obtained after incubation of the muscle for 90 min with antagonists for M1 (pirenzepine),M2 (methoctramine) and M3 (darifenacin) muscarinic receptor subtypes. The sensitivity to PTX was tested by the ip injection of 100 mg/kg of PTX 5 d before the experiment. The antral circular smooth muscles were removed from PTX-treated and non-treated rats as strips and dispersed smooth muscle cells to identify whether PTX-linked pathway mediated the contractility to bethanechol.RESULTS: A dose-dependent contractile response observed with bethanechol, was not affected by TTX. The pretreatment of rats with pertussis toxin decreased the contraction induced by bethanechol. Lack of calcium as Well as the presence of the L-type calcium channel blocker, nifedipine, also inhibited the cholinergic contraction, with a reduction in response from 2.5±0.4 g/mm2 to 1.2±0.4 g/mm2 (P<0.05). The doseresponse curves were shifted to the right by muscarinic antagonists in the following order of affinity: darifenacin(M3)>methocramine (M2)>pirenzepine (M1).CONCLUSION: The muscarinic receptors-dependent contraction of rat antral circular smooth muscles was linked to the signal transduction pathway(s) involving pertussis-toxin sensitive GTP-binding proteins and to extracellular calcium via L-type voltage gated calcium channels. The presence of the

  8. The jurisprudence of responsive mediation: An empirical examination of Chinese people's mediation in action

    OpenAIRE

    Ali, S

    2013-01-01

    Community mediation in China has a long history and finds its roots in both cultural (traditional Confucian ideologies) and functional (the avoidance of social conflicts) aims. Recently, however, owing to changes in societal values occurring alongside China’s economic open-door policy, traditional values are losing their prominent role in the mediation process. Meanwhile, reforms are being carried out to provide greater structure to community mediation in China. The combination of these chang...

  9. Flavorful hybrid anomaly-gravity mediation

    International Nuclear Information System (INIS)

    We consider supersymmetric models where anomaly and gravity mediation give comparable contributions to the soft terms and discuss how this can be realized in a five-dimensional brane world. The gaugino mass pattern of anomaly mediation is preserved in such a hybrid setup. The flavorful gravity-mediated contribution cures the tachyonic slepton problem of anomaly mediation. The supersymmetric flavor puzzle is solved by alignment. We explicitly show how a working flavor-tachyon link can be realized with Abelian flavor symmetries and give the characteristic signatures of the framework, including O(1) slepton mass splittings between different generations and between doublets and singlets. This provides opportunities for same flavor dilepton edge measurements with missing energy at the Large Hadron Collider (LHC). Rare lepton decay rates could be close to their current experimental limit. Compared to pure gravity mediation, the hybrid model is advantageous because it features a heavy gravitino which can avoid the cosmological gravitino problem of gravity-mediated models combined with leptogenesis.

  10. Ombuds’ corner: Consider mediation - some rules

    CERN Multimedia

    Vincent Vuillemin

    2013-01-01

    Mediation is a structured process in which an external party, called a mediator, helps participants generate and evaluate options that would allow them to reach a mutual agreement. It is an informal and confidential process.   The mediator does not have the power to impose an agreement on the parties, who should find it by themselves. However, the mediator controls the process. He arranges the meetings in agreement with the parties, and coordinates the details (concerning the speaking times, for example) and ensures that the parties respect of the rules which have been agreed on. He also favours advancing of the process towards a solution. The mediation process is centred on the search for a solution and a mutual agreement. In such a process, the mediator takes a neutral and impartial position, and does not advocate for a single party. He favours good communication between the parties, and will ensure that mutual respect is maintained and that the correct language is used during the discussi...

  11. Wide area sensor network

    Science.gov (United States)

    Mukhopadhyay, Sanjoy; Nix, Tricia; Junker, Robert; Brentano, Josef; Khona, Dhiren

    2006-05-01

    The technical concept for this project has existed since the Chernobyl accident in 1986. A host of Eastern European nations have developed countrywide grid of sensors to monitor airborne radiation. The objective is to build a radiological sensor network for real-time monitoring of environmental radiation levels in order to provide data for warning, and consequentially the assessment of a nuclear event. A network of radiation measuring equipment consisting of gamma, neutron, alpha, and beta counters would be distributed over a large area (preferably on fire station roof tops) and connected by a wireless network to the emergency response center. The networks would be deployed in urban environments and would supply first responders and federal augmentation teams (including those from the U.S. Departments of Energy, Defense, Justice, and Homeland Security) with detailed, accurate information regarding the transport of radioactive environmental contaminants, so the agencies can provide a safe and effective response. A networked sensor capability would be developed, with fixed sensors deployed at key locations and in sufficient numbers, to provide adequate coverage for early warning, and input to post-event emergency response. An overall system description and specification will be provided, including detector characteristics, communication protocols, infrastructure and maintenance requirements, and operation procedures. The system/network can be designed for a specifically identified urban area, or for a general urban area scalable to cities of specified size. Data collected via the network will be transmitted directly to the appropriate emergency response center and shared with multiple agencies via the Internet or an Intranet. The data collected will be managed using commercial off - the - shelf Geographical Information System (GIS). The data will be stored in a database and the GIS software will aid in analysis and management of the data. Unique features of the

  12. Dispute Settlement through Banking Mediation

    Directory of Open Access Journals (Sweden)

    Angelica ROSU

    2010-11-01

    earlier legislation and the current legislation, the Emergency Ordinance no. 113/2009, this document proposing the establishment of a specialized department that is responsible with the resolution of disputes between consumers and financial service providers ofbanking and insurance. However, although in 2004 we have legislation that enables the implementation of mediation as a means of dispute settlement in the banking sector (Government Ordinance. 6 / 2004, the practical delays occur.

  13. Local area networks

    CERN Document Server

    Zafiropoulo, P

    1982-01-01

    Pitro Zafiropulo is a- staff member at the IBM Research Laboratories at Zurich. He joined IBM in 1968 and has worked on protocol validation, synthesis, integrated networks, network reliability, PABX's and speech recognition. Local Area Networks are intended to provide improved communication capabilities such as high data throughput rates, low error rates and ease of connection among terminal stations and comuters. These new types of networks operate within a limited geographical range like an establishment, campus or building and are owned by a single organization. The presentation introduces these networks and the main techniques are described. It then proceeds to evaluate the main switching techniques as they apply to LAN ring and bus configurations. The preferred technique of token-ring distributed switching is identified. The contents of Mr. Zafiropoulo's talk was somewhat similar to the paper of Mr. Kummerle, which is therefore included in these Proceedings.

  14. Phoenix Work Area Animation

    Science.gov (United States)

    2008-01-01

    [figure removed for brevity, see original site] Click on image for animation This animation from Sol 1 shows a mosaic of the Phoenix digging area in the Martian terrain. Phoenix scientists are very pleased with this view as the terrain features few rocks an optimal place for digging. The mast of the camera looks disjointed because the photos that comprise this mosaic were taken at different times of day. This video also show some of the lander's instrumentation. The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

  15. Construction of Mediators for Heterogeneous Data Source Integration Systems

    Institute of Scientific and Technical Information of China (English)

    高明; 宋瀚涛

    2003-01-01

    To construct mediators for data integration systems that integrate structured and semi-structured data, and to facilitate the reformulation and decomposition of the query, the presented system uses the XML processing language (XPL) for the mediator. With XPL, it is easy to construct mediators for data integration based on XML, and it can accelerate the work in the mediator.

  16. A State Space Modeling Approach to Mediation Analysis

    Science.gov (United States)

    Gu, Fei; Preacher, Kristopher J.; Ferrer, Emilio

    2014-01-01

    Mediation is a causal process that evolves over time. Thus, a study of mediation requires data collected throughout the process. However, most applications of mediation analysis use cross-sectional rather than longitudinal data. Another implicit assumption commonly made in longitudinal designs for mediation analysis is that the same mediation…

  17. 29 CFR 1207.2 - Requests for Mediation Board action.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Requests for Mediation Board action. 1207.2 Section 1207.2 Labor Regulations Relating to Labor (Continued) NATIONAL MEDIATION BOARD ESTABLISHMENT OF SPECIAL ADJUSTMENT BOARDS § 1207.2 Requests for Mediation Board action. (a) Requests for the National Mediation...

  18. 15 CFR 923.83 - Mediation of amendments.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Mediation of amendments. 923.83... Programs § 923.83 Mediation of amendments. (a) Section 307(h)(2) of the Act provides for mediation of... management program. Accordingly mediation is available to states or federal agencies when a...

  19. Estimating and Testing Mediation Effects with Censored Data

    Science.gov (United States)

    Wang, Lijuan; Zhang, Zhiyong

    2011-01-01

    This study investigated influences of censored data on mediation analysis. Mediation effect estimates can be biased and inefficient with censoring on any one of the input, mediation, and output variables. A Bayesian Tobit approach was introduced to estimate and test mediation effects with censored data. Simulation results showed that the Bayesian…

  20. 15 CFR 930.115 - Termination of mediation.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Termination of mediation. 930.115... MANAGEMENT FEDERAL CONSISTENCY WITH APPROVED COASTAL MANAGEMENT PROGRAMS Secretarial Mediation § 930.115 Termination of mediation. Mediation shall terminate: (a) At any time the Federal and State agencies agree to...

  1. Surveying Parental Mediation: Connections, Challenges and Questions for Media Literacy

    Science.gov (United States)

    Mendoza, Kelly

    2009-01-01

    This paper examines three strategies of parental mediation--coviewing, restrictive mediation, and active mediation--in order to make connections, challenge, and raise questions for media literacy. Coviewing, whether it is intentional practice, or whether it functions to promote media literacy, is explored. Restrictive mediation, how it connects to…

  2. Reducing Levels of Elementary School Violence with Peer Mediation

    Science.gov (United States)

    Schellenberg, Rita Cantrell; Parks-Savage, Agatha; Rehfuss, Mark

    2007-01-01

    The effectiveness of an existing peer mediation program in a diverse, suburban elementary school was examined. Peer mediation was available to all students (N = 825). Three-year longitudinal data showed significant reductions in the school's out-of-school suspensions after implementation of the peer mediation program. Mediation training also…

  3. Mediating factors of land use change among coffee farmers in a biological corridor

    DEFF Research Database (Denmark)

    Bosselmann, Aske Skovmand

    2012-01-01

    Trees in agricultural landscapes are important for the provision of environmental services. This study assesses the loss of shade coffee during a 9 year period in a biological corridor in Costa Rica, and investigates the mediating factors of land use change. Following a conceptual framework...... that presents how household and farm characteristics mediate the interplay between underlying and proximate causes of land use change, the effect of the mediating factors is determined by applying an ordered probit model to household and land use data for 2000 and 2009 from 217 former and present coffee farmers....... Additional 224 telephone interviews supplement the data on land use change. Results show a 50% reduction in the coffee area and a corresponding loss of trees. Family labor, age of household head, coffee prices, and use of shade tree products significantly reduce the probability of converting the coffee field...

  4. MANAGEMENT IN RURAL AREAS

    Directory of Open Access Journals (Sweden)

    Danimir Štros

    2015-07-01

    Full Text Available Croatia has been seeking to achive pre-war results in tourism since its independence. Rural tourism in Croatia based on family farma faces a number of problems legal foundations, the involement of local communities, inadequate entepreneur support etc. The political will for development exists, but there is lack of willingness and the ability to get things started, which results in the closure of family farma who cannot cope with the parallel job of agriculture and tourism. Arriving guests certainly want a new type of tourism: peace, clean environment, cultural intangible and tangible treasures, all without the noise and stress; and Croatia can definitely offer it, either in coastal or inland areas with traditional food and drinks. The destinations connection is not satisfactora. there is also an evident lack of legislation and regional spatial development plans for sustainable tourism which is a prerequisite for successful tourism. With these plans presumptins accepted, Croatian tourism would become distinctive and inland and coastal branches of tourism could complement each other so that the customer can spend his vacation both in the continental ant the maritime part of the country, getting to know our culture and enjoy the traditional cousine.

  5. Mir-434-5p mediates skin whitening and lightening

    Directory of Open Access Journals (Sweden)

    David TS Wu

    2008-10-01

    Full Text Available David TS Wu, Jack S Chen, Donald C Chang, Shi-Lung LinInstitute of Mello Biotechnology, Taipei, Taiwan, ROCAbstract: Utilization of gene silencing effectors, such as microRNA (miRNA and small airpin RNA (shRNA, provides a powerful new strategy for human skin care in vivo, particularly for hyperpigmentation treatment and aging prevention. In this study, tyrosinase (Tyr, the rate-limiting enzyme of melanin (black pigment biosynthesis, was served as a target for treatment of hyperpigmentation in mouse and human skins. There are over 54 native microRNA capable of silencing human tyrosinase for skin whitening and lightening. To this, we have designed a mir-434-5p homologue and used it to successfully demonstrate the feasibility of miRNA-mediated skin whitening and lightening in vitro and in vivo. Under the same experimental condition in the trials, Pol-II-directed intronic mir-434-5p expression did not cause any detectable sign of cytotoxicity, whereas siRNAs targeting the same sequence often induced certain nonspecific mRNA degradation as previously reported. Because the intronic miRNA-mediated gene silencing pathway is tightly regulated by multiple intracellular surveillance systems, including Pol-II transcription, RNA splicing, exosomal digestion and nonsense-mediated RNA decay (NMD, the current findings underscore the fact that intronic miRNA agents, such as manually re-designed mir-434-5p homologues, are effective, target-specific and safe to be used for skin whitening without any detectable cytotoxic effect. Given that the human skins also express a variety of other native miRNAs, we may re-design these miRNAs based on their individual functions for skin care, which may provide significant insights into areas of opportunity for new cosmetic and/or therapeutical applications.Keywords: microRNA, miRNA, mir-434, intron, gene silencing, RNAi, tyrosinase, melanin, cosmetics, pigmentation, skin whitening

  6. Federal Sand and Gravel Borrow Areas (Lease Areas)

    Data.gov (United States)

    Bureau of Ocean Energy Management, Department of the Interior — Federal outer Continental Shelf (OCS) Sand and Gravel Borrow Areas (Lease Areas) are polygons which are maintained by the Bureau of Ocean Energy Management (BOEM),...

  7. Water Service Areas - Public Water Supplier's (PWS) Service Areas

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Boundaries of current public water supplier's (PWS) service areas. This data set contains the present service area boundary of the water system and does not contain...

  8. DISPUTE RESOLUTION AND MEDIATION ON CAPITAL MARKET

    Directory of Open Access Journals (Sweden)

    CRISTIAN GHEORGHE

    2011-04-01

    Full Text Available Capital Market is usually depicted as a place for experts, for people with high trading skills. This is a half truth. There are entities established and functioning under strict scrutiny of Romanian National Securities Commission (RNSC, in compliance with Capital Market Law and regulations. There are also the investors, in many cases individuals involved in shares/financial instruments trade. In both cases disputes can rise. Disputes are inevitable a part of human interaction, hence the need for dispute resolution. First option is the judicial court system. Alternative dispute resolution comprises arbitration and mediation. Arbitration is an alternative choice to provide simpler, speedier and more accessible justice than ordinary courts as well as expertise in matters that are technical in nature and require special knowledge to adjudicate upon. Capital Market environment provides an institutional arbitration court for all participants, including investors. In many cases the agreement executed between participants under RNSC scrutiny The other option for settling disputes outside the court is mediation. Mediation can provide a much cheaper and quick extrajudicial resolution of disputes in commercial matters without time consuming procedures and rigid rules. Agreements resulting from mediation are more likely to be complied with voluntarily and are more likely to foster the commercial relationship between the parties. The interaction between investors and brokerage houses is based on investment services agreement concluded by parties. This is the usual framework for disputes between parties and the usual “landscape” for mediation on capital market.

  9. Light mediators in dark matter direct detections

    International Nuclear Information System (INIS)

    In an extended effective operator framework, we investigate in detail the effects of light mediators on the event spectra of dark matter (DM)-nucleus scatterings. The presence of light mediators changes the interpretation of the current experimental data, especially the determination of DM particle mass. We show by analytic and numerical illustrations that in general for all the operators relevant to spin-independent scatterings, the DM particle mass allowed by a given set of experimental data increases significantly when the mediator particle becomes lighter. For instance, in the case of CDMS-II-Si experiment, the allowed DM particle mass can reach ∼50 (100) GeV at 68% (90%) confidence level, which is much larger than ∼10 GeV in the case with contact interactions. The increase of DM particle mass saturates when the mediator mass is below O(10) MeV. The upper limits from other experiments such as SuperCDMS, CDMSlite, CDEX, XENON10/100, LUX, PandaX etc. all tend to be weaker toward high DM mass regions. In a combined analysis, we show that the presence of light mediators can partially relax the tension in the current results of CDMS-II-Si, SuperCDMS and LUX

  10. A neural mediator of human anxiety sensitivity.

    Science.gov (United States)

    Harrison, Ben J; Fullana, Miquel A; Soriano-Mas, Carles; Via, Esther; Pujol, Jesus; Martínez-Zalacaín, Ignacio; Tinoco-Gonzalez, Daniella; Davey, Christopher G; López-Solà, Marina; Pérez Sola, Victor; Menchón, José M; Cardoner, Narcís

    2015-10-01

    Advances in the neuroscientific understanding of bodily autonomic awareness, or interoception, have led to the hypothesis that human trait anxiety sensitivity (AS)-the fear of bodily autonomic arousal-is primarily mediated by the anterior insular cortex. Despite broad appeal, few experimental studies have comprehensively addressed this hypothesis. We recruited 55 individuals exhibiting a range of AS and assessed them with functional magnetic resonance imaging (fMRI) during aversive fear conditioning. For each participant, three primary measures of interest were derived: a trait Anxiety Sensitivity Index score; an in-scanner rating of elevated bodily anxiety sensations during fear conditioning; and a corresponding estimate of whole-brain functional activation to the conditioned versus nonconditioned stimuli. Using a voxel-wise mediation analysis framework, we formally tested for 'neural mediators' of the predicted association between trait AS score and in-scanner anxiety sensations during fear conditioning. Contrary to the anterior insular hypothesis, no evidence of significant mediation was observed for this brain region, which was instead linked to perceived anxiety sensations independently from AS. Evidence for significant mediation was obtained for the dorsal anterior cingulate cortex-a finding that we argue is more consistent with the hypothesized role of human cingulofrontal cortex in conscious threat appraisal processes, including threat-overestimation. This study offers an important neurobiological validation of the AS construct and identifies a specific neural substrate that may underlie high AS clinical phenotypes, including but not limited to panic disorder. PMID:26147233

  11. Architecture of the Mediator head module

    Energy Technology Data Exchange (ETDEWEB)

    Imasaki, Tsuyoshi; Calero, Guillermo; Cai, Gang; Tsai, Kuang-Lei; Yamada, Kentaro; Cardelli, Francesco; Erdjument-Bromage, Hediye; Tempst, Paul; Berger, Imre; Kornberg, Guy Lorch; Asturias, Francisco J.; Kornberg, Roger D.; Takagi, Yuichiro (Stanford); (Indiana-Med); (EMBL); (Scripps); (MSKCC)

    2011-09-06

    Mediator is a key regulator of eukaryotic transcription, connecting activators and repressors bound to regulatory DNA elements with RNA polymerase II (Pol II). In the yeast Saccharomyces cerevisiae, Mediator comprises 25 subunits with a total mass of more than one megadalton (refs 5, 6) and is organized into three modules, called head, middle/arm and tail. Our understanding of Mediator assembly and its role in regulating transcription has been impeded so far by limited structural information. Here we report the crystal structure of the essential Mediator head module (seven subunits, with a mass of 223 kilodaltons) at a resolution of 4.3 angstroms. Our structure reveals three distinct domains, with the integrity of the complex centred on a bundle of ten helices from five different head subunits. An intricate pattern of interactions within this helical bundle ensures the stable assembly of the head subunits and provides the binding sites for general transcription factors and Pol II. Our structural and functional data suggest that the head module juxtaposes transcription factor IIH and the carboxy-terminal domain of the largest subunit of Pol II, thereby facilitating phosphorylation of the carboxy-terminal domain of Pol II. Our results reveal architectural principles underlying the role of Mediator in the regulation of gene expression.

  12. Realistic anomaly mediation with bulk gauge fields

    International Nuclear Information System (INIS)

    We present a simple general framework for realistic models of supersymmetry breaking driven by anomaly mediation. We consider a 5-dimensional 'brane universe' where the visible and hidden sectors are localized on different branes, and the standard model gauge bosons propagate in the bulk. In this framework there can be charged scalar messengers that have contact interactions with the hidden sector, either localized in the hidden sector or in the bulk. These scalars obtain soft masses that feed into visible sector scalar masses at two loop order via bulk gauge interactions. This contribution is automatically flavor-blind, and can be naturally positive. If the messengers are in the bulk this contribution is automatically the same order of magnitude as the anomaly mediated contribution, independent of the brane spacing. If the messengers are localized to a brane the two effects are of the same order for relatively small brane spacings. The gaugino masses and A terms are determined completely by anomaly mediation. In order for anomaly mediation to dominate over radion mediation the radion must be is stabilized in a manner that preserves supersymmetry, with supergravity effects included. We show that this occurs in simple models. We also show that the mu problem can be solved by the vacuum expectation value of a singlet in this framework. (author)

  13. Mirage Models Confront the LHC: III. Deflected Mirage Mediation

    OpenAIRE

    Everett, Lisa L.; Garon, Todd; Kaufman, Bryan L.; Nelson, Brent D

    2015-01-01

    We complete the study of a class of string-motivated effective supergravity theories in which modulus-induced soft supersymmetry breaking is sufficiently suppressed in the observable sector so as to be competitive with anomaly-mediated supersymmetry breaking. Here we consider deflected mirage mediation (DMM), where contributions from gauge mediation are added to those arising from gravity mediation and anomaly mediation. We update previous work that surveyed the rich parameter space of such t...

  14. Human Communication as Mediating the Units of Parameterised Environment

    OpenAIRE

    Josip Stepanic

    2004-01-01

    Human communication is prevalently a mediated process. Mediators are units of environment, which are attributed functions within the local value set. They are utilised in such a way as to optimise the change of human states. In this article, a mediator-centred interpretation of the human communication is given. The interpretation follows closely the concept of mediated interaction developed within physics. It is conjectured that collection of mediators, which the humans use, has a well-define...

  15. Reclamation of urban areas

    International Nuclear Information System (INIS)

    A literature study was conducted in order to compare the effectiveness and cost of different reclamation procedures that may be employed after an accident on a nuclear facility takes place in which radioactive material is released to the atmosphere. A substantial amount of work has been done on reclaming soil and snow-covered surfaces. Using scrapers or other soil-moving equipment decontamination factors are 10-100. (The decontamination factor is the ratio of the contamination before to that after the decontamination procedure). However, information on decontamination of paved areas by simple methods such as firehosing and vacuum sweeping are poorly documented. Therefore, only a very uncertain figure in the range 2-10 can be given for the decontamination factor here. It is recommended that a major effort be made in the future to investigate the efficiency of these simple methods, because of their relatively low cost. Also, more expensive methods for reducing the dose such as vacuuming, road planing and deep plowing are treated because of their feasibility under certain circumstances. Using these methods dose reduction factors in the 2-100 range can be obtained. Very expensive techniques, such as sandblasting, water cannon, flame spalling, etc. are justifiable usable only in special situations and are therefore considered very briefly here. The methods vary widely in cost. A simple method like vacuum sweeping costs $0.004 per square meter of surface; whereas one like road planing can reach $4 per square meter. A more sophisticated technique like flame spalling costs as much as $100 per square meter. (author)

  16. Recent advances in engineering topography mediated antibacterial surfaces

    Science.gov (United States)

    Hasan, Jafar; Chatterjee, Kaushik

    2015-09-01

    The tendency of bacterial cells to adhere and colonize a material surface leading to biofilm formation is a fundamental challenge underlying many different applications including microbial infections associated with biomedical devices and products. Although, bacterial attachment to surfaces has been extensively studied in the past, the effect of surface topography on bacteria-material interactions has received little attention until more recently. We review the recent progress in surface topography based approaches for engineering antibacterial surfaces. Biomimicry of antibacterial surfaces in nature is a popular strategy. Whereas earlier endeavors in the field aimed at minimizing cell attachment, more recent efforts have focused on developing bactericidal surfaces. However, not all such topography mediated bactericidal surfaces are necessarily cytocompatible thus underscoring the need for continued efforts for research in this area for developing antibacterial and yet cytocompatible surfaces for use in implantable biomedical applications. This mini-review provides a brief overview of the current strategies and challenges in the emerging field of topography mediated antibacterial surfaces.

  17. Socialising Semiotic Mediation: Some Reflections on Rosa and Pievi's Paper

    Directory of Open Access Journals (Sweden)

    Glaveanu, V.

    2013-11-01

    Full Text Available This article aims to reflect on the relation between social representations theory (SRT and a cultural psychological view of semiotics, as presented in Rosa and Pievi's paper (this issue. It is argued that a fruitful dialogue can be established between the two orientations, one that draws on similarities but also addresses and exploits several important conceptual differences. The article proceeds by outlining the areas in which SRT can be enriched by a semiotic account – such as incorporating a more clearly articulated theory of signs and unpacking further the role of mediated action and personal experience – as well as the ways in which the latter can benefit from engaging with the notion of social representations. Most of all, I propose that what a SRT-informed view of cultural psychology can offer us is a ‘socialized model of semiotic mediation', one that grounds the construction of knowledge at the level of different groups and communities and observes its dynamic evolution over time in close relation to these social milieus. The transformation of knowledge and its individual and social determinants are considered in detail by SRT researchers and can expand the rather narrow focus on sign, object and meaning in more traditional forms of semiotic analysis. In the end, some methodological reflections are offered and the existence of social representations as a phenomenon is affirmed beyond the realm of purely scientific construction.

  18. Robot-Mediated Imitation Skill Training for Children With Autism.

    Science.gov (United States)

    Zheng, Zhi; Young, Eric M; Swanson, Amy R; Weitlauf, Amy S; Warren, Zachary E; Sarkar, Nilanjan

    2016-06-01

    Autism spectrum disorder (ASD) impacts 1 in 68 children in the U.S., with tremendous individual and societal costs. Technology-aided intervention, more specifically robotic intervention, has gained momentum in recent years due to the inherent affinity of many children with ASD towards technology. In this paper we present a novel robot-mediated intervention system for imitation skill learning, which is considered a core deficit area for children with ASD. The Robot-mediated Imitation Skill Training Architecture (RISTA) is designed in such a manner that it can operate either completely autonomously or in coordination with a human therapist depending on the intervention need. Experimental results are presented from small user studies validating system functionality, assessing user tolerance, and documenting subject performance. Preliminary results show that this novel robotic system draws more attention from the children with ASD and teaches gestures more effectively as compared to a human therapist. While no broad generalized conclusions can be made about the effectiveness of RISTA based on our small user studies, initial results are encouraging and justify further exploration in the future. PMID:26353376

  19. Does drinking refusal self-efficacy mediate the impulsivity-problematic alcohol use relation?

    Science.gov (United States)

    Stevens, Angela K; Littlefield, Andrew K; Blanchard, Brittany E; Talley, Amelia E; Brown, Jennifer L

    2016-02-01

    There is consistent evidence that impulsivity-like traits relate to problematic alcohol involvement; however, identifying mechanisms that account for this relation remains an important area of research. Drinking refusal self-efficacy (or a person's ability to resist alcohol; DRSE) has been shown to predict alcohol use among college students and may be a relevant mediator of the impulsivity-alcohol relation. The current study examined the indirect effect of various constructs related to impulsivity (i.e., urgency, sensation seeking, and deficits in conscientiousness) via several facets of DRSE (i.e., social pressure, opportunistic, and emotional relief) on alcohol-related problems among a large sample of college students (N=891). Overall, results indicated that certain DRSE facets were significant mediators of the relation between impulsivity-related constructs and alcohol problems. More specifically, emotional-relief DRSE was a mediator for the respective relations between urgency and deficits in conscientiousness and alcohol problems, whereas social-DRSE was a significant mediator of the respective relations between urgency and sensation seeking with alcohol problems. Results from this study suggest particular types of DRSE are important mediators of the relations between specific impulsivity constructs and alcohol-related problems. These findings support prevention and intervention efforts that seek to enhance drinking refusal self-efficacy skills of college students, particularly those high in certain personality features, in order to reduce alcohol-related problems among this population. PMID:26547044

  20. Fragments of “analytics” of mediatization

    Directory of Open Access Journals (Sweden)

    Antônio Fausto Neto

    2008-04-01

    Full Text Available The text intends, through a dialogue with authors, to reflect about the concept of “analytics of the mediatization”, taking the evolution from the “society of means” to the “mediatic society” as reference. It ties the emergency of this new “interpretative strategies” to the increasing autonomy of the media field, that imposes, from its part, transformation in the “contracts” and in the bonds between the production structures and the reception of mediatic discourses. Finally, it proposes the  comprehension of this “analytics” as a concept associated to the practices that are structured and developed from operations of sense engendered in the enunciative ambit of the mediatic culture.

  1. U(1) mediation of flux supersymmetry breaking

    International Nuclear Information System (INIS)

    We study the mediation of supersymmetry breaking triggered by background fluxes in Type II string compactifications with N = 1 supersymmetry. The mediation arises due to an U(1) vector multiplet coupling to both a hidden supersymmetry breaking flux sector and a visible D-brane sector. The required internal manifolds can be constructed by non-Kaehler resolutions of singular Calabi-Yau manifolds. The effective action encoding the U(1) coupling is then determined in terms of the global topological properties of the internal space. We investigate suitable local geometries for the hidden and visible sector in detail. This includes a systematic study of orientifold symmetries of del Pezzo surfaces realized in compact geometries after geometric transition. We construct compact examples admitting the key properties to realize flux supersymmetry breaking and U(1) mediation. Their toric realization allows us to analyze the geometry of curve classes and confirm the topological connection between the hidden and visible sector.

  2. Considerations about mediative in initial petition

    Directory of Open Access Journals (Sweden)

    Maria das Vitórias Nunes Silva Lourenço

    2013-12-01

    Full Text Available This paper presents considerations about Initial Petition, textual/discursive genre, which is a genre circumscribed in the judicial domain with relation to the Commitment. For this purpose, this article exposes the text plan of the Initial Petition from the postulations of Adam (2011. In the same way, it studies the mediative frameworks based on Guentchéva (1994, 1996, which develop the notion of mediative grammatical categories, that permits the linguistic marking of distance and engagement of the enunciator with regard to the information expressed. It evidences the relevance of the use of mediated constructions in the judicial text, as they function as attenuated strategies to the responsibility of the producer of the text with what is said, and at the same time points to a discourse of authority through the entrance of the sources of law.

  3. Digital methods for mediated discourse analysis

    DEFF Research Database (Denmark)

    Kjær, Malene; Larsen, Malene Charlotte

    2015-01-01

    practice of health care professionals (Author 1, 2014) and 2) young people’s identity construction on social media platforms (Author 2, 2010, 2015, in press). The paper’s contribution is a methodological discussion on digital data collection using methods such as online interviewing (via e-mail or chat......In this paper we discuss methodological strategies for collecting multimodal data using digital resources. The aim is to show how digital resources can provide ethnographic insights into mediated actions (Scollon, 2002) that can otherwise be difficult to observe or engage in, due to, for instance......, restrictions or privately mediated settings. Having used mediated discourse analysis (Scollon 2002, Scollon & Scollon, 2004) as a framework in two different research projects, we show how the framework, in correlation with digital resources for data gathering, provides new understandings of 1) the daily...

  4. Enhancing Educational Opportunities with Computer-Mediated Assessment Feedback

    Directory of Open Access Journals (Sweden)

    David Tuffley

    2015-08-01

    Full Text Available As internet technologies make their way into developing areas, so too does the possibility of education and training being delivered to the people living in those previously unserved areas. The growing catalogue of free, high quality courseware, when combined with the newly acquired means of delivery, creates the potential for millions of people in the developing world to acquire a good education. Yet a good education obviously requires more than simply delivering information; students must also receive high quality feedback on their assessments. They must be told how their performance compares with the ideal, and be shown how to close the gap between the two. However, delivering high quality feedback is labor-intensive, and therefore expensive, and has long been recognized as a problematic issue by educators. This paper outlines a case study that uses a Learning Management System (LMS to efficiently deliver detailed feedback that is informed by the principles of best practice. We make the case that the efficiencies of this method allow for large-scale courses with thousands of enrolments that are accessible to developing and developed areas alike. We explore the question; is computer-mediated feedback delivery efficient and effective and might it be applied to large-scale courses at low-cost?

  5. LIHTC Difficult to Develop Areas

    Data.gov (United States)

    Department of Housing and Urban Development — A Difficult Development Area (DDA) for the Low Income Housing Tax Credit program is an area designated by the U.S. Department of Housing and Urban Development (HUD)...

  6. Catch-In-Areas Main

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Catch-In-Areas database integrates catch data from the Catch Accounting System (which has the spatial resolution of a NMFS Reporting Area) into a database that...

  7. Area monitoring intelligent system - SIMA

    International Nuclear Information System (INIS)

    The area monitoring intelligent system (SIMA) is an equipment to be used in radioprotection. SIMA has the function of monitoring the radiation levels of determined areas of the installations where radioactive materials are handled. (Author)

  8. COMBUSTION AREA SOURCES: DATA SOURCES

    Science.gov (United States)

    The report identifies, documents, and evaluates data sources for stationary area source emissions, including solid waste and agricultural burning. Area source emissions of particulate matter, sulfur dioxide, oxides of nitrogen, reactive volatile organic compounds, and carbon mon...

  9. Major Land Resource Areas (MLRA)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This is a polygon coverage of the Land Resource Regions and Major Land Resource Areas of the conterminous United States. Land resource regions are geographic areas...

  10. Laguna Atascosa Wilderness study area

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document is a brief report on a wilderness study area located in the Laguna Atascosa National Wildlife Refuge. It discusses the history of the study area, its...

  11. Cholera in Azov area

    Directory of Open Access Journals (Sweden)

    O. N. Domashenko

    2015-07-01

    Full Text Available The purpose of research is analysis of clinical course and treatment results of patients with cholera in the Azov area. Materials and methods. During the period from 29.05.2011 to 19.08.2011 33 cases of cholera (32 adults and 1 child and 25 vibrio carriers (22 adults and 3 children, which were caused by toxigenic strains of Vibrio cholera El Tor serogroup O1 Ogawa. Results. Likely factors of disease transmission in Mariupol are sea and river water, and the fish that were caught in the waters of the city. Typical and watery diarrhoea, vomiting, abdominal pain and lack of normal body temperature, dehydration syndrome, characterized clinical cholera for adults in most cases. The mean duration of diarrhoea was 6,6 days. At 46.9% observed atypical symptoms in 10 (31,3% – abdominal pain (1 patient cramping in 7 cases, localized in the epigastria region, at 2-over stomach. In 5 patients (15,6% had an increase in body temperature to 37,2–37,7 degrees Celsius. In 15 (46,9% patients had severe nausea accompanied by vomiting. Easy for cholera was observed in 1 (3.1%, moderate – in 14 (43,8%, heavy – in 17 (53,1% patients. Dehydration I level is set at 4 (12,5%, II – from 6 (18,7%, III – in 18 (56,3%, IV – 4 (12,5% patients. Cholera outbreak was characterized by a predominance of severe disease and severe dehydration (III and IV, which was observed in 68.8% of patients. The decisive factor in the treatment of cholera patients was initiated in a timely manner rehydration therapy, in particular the introduction of the solution «Trisol». Against the background of rehydration therapy hyperkalaemia was observed in 9,4% of cases, vascular rehydration at 9,4%, the cell rehydration in 3,1% of patients. Fatal accidents cholera outbreaks have not been observed. Conclusion. Clinical diagnosis of cholera and the provision of medical care in the prehospital phase were poor, indicating the need for systematic conducting training seminars among experts

  12. Angular dependence of surfactant-mediated forces between carbon nanotubes.

    Science.gov (United States)

    Müter, Dirk; Angelikopoulos, Panagiotis; Bock, Henry

    2012-12-27

    We employ dissipative particle dynamics to examine surfactant-mediated forces between two carbon nanotubes. Calculations are performed varying both the distance and the angle between the nanotubes. For small distances, a repulsive region is observed, followed by an overall attractive interval with strong oscillations in the force. Decreasing the angle between the tubes leads to a steady increase in the force, but the relative dependence on the separation distance is preserved. We find that the force scales linearly with the size of the overlap area between the tubes. This allows us to express the angle dependence by a simple equation, whereas the distance dependence is represented by a master curve. For the parallel case, the behavior is significantly different. PMID:23116052

  13. Video mediated teaching of young students in peripheral regions of the Nordic countries - a discussion of problems and potentials

    DEFF Research Database (Denmark)

    Andreasen, Karen Egedal

    mediated teaching seems to be demanding for some students especially students with different kinds of social or academic problems. Wenger, E. (1998). Communities of Practice: Learning, Meaning, and Identity. Cambridge University Press. Andreasen, K. E. (2012). VIU: Projekt VIrtuel Undervisning : Rapport...... these areas with education and has given rise to an increase in the interest of using video mediated teaching. Recent years several experiments have been implemented in Denmark and in the Nordic countries in general. In a Danish region a comprehensive innovation project including video mediated...... of learning in such environments. Results from the research indicate that the video mediated teaching has serious impact on student participation. Among other things students have to be able to work very independently and discussions and dialogues in class are influenced by the technology. The video...

  14. Heavy gravitino, naturalness, and sizable anomaly mediation

    OpenAIRE

    Maekawa, Nobuhiro; Takayama, Kenichi

    2014-01-01

    We consider the situation in which $m_{3/2}\\sim O(100{\\rm TeV})$ for solving the gravitino problem and the other supersymmetry(SUSY) breaking parameters are $O(1{\\rm TeV})$ for the naturalness. We point out that the anomaly mediation cancels out the renormalization group contribution to the gaugino masses and the sfermion masses other than the stop masses at a scale which is called the mirage scale. The situation is similar to the mirage mediation, in which special boundary conditions for the...

  15. Metatv: the mediation as an apprehended reality

    Directory of Open Access Journals (Sweden)

    Márcio Serelle

    2009-06-01

    Full Text Available The television that narrates itself, as an intensification of neotv skills, pointed out by Eco, emphasizes their mediation processes, as the reality to be apprehended by the spectators was that of the medium’s inner side. Considering the notions of media transparency and opacity, this article aims at analyzing the meanings of this metalanguage acts present in many levels of the programming. This text examines closely the enunciation strategies of two programs: Profissão reporter and Cena aberta, which specular attitude reveals, in the media culture, the fascination by television mediation.

  16. A simple model of direct gauge mediation

    Energy Technology Data Exchange (ETDEWEB)

    Zheng Sibo, E-mail: sibozheng.zju@gmail.com [Department of Physics, Chongqing University, Chongqing 401331 (China); Yu Yao [Department of Physics, Chongqing University, Chongqing 401331 (China)

    2012-03-23

    In the context of direct gauge mediation Wess-Zumino models are very attractive in supersymmetry model building. Besides the spontaneous supersymmetry and R-symmetry breaking, the problems of small gaugino mass as well as {mu} and B{mu} terms should be solved so as to achieve a viable model. In this Letter, we propose a simple model as an existence proof, in which all these subjects are realized simultaneously, with no need of fine tuning. This completion also implies that much of parameter space for direct gauge mediation can be directly explored at LHC.

  17. Criminal mediation for minors in Israel.

    Science.gov (United States)

    Kandel, Isack; Arie, Yael; Glasner, Sharon

    2007-01-01

    Mediation was introduced in Canada in 1974 in order to handle a crime of robbery and vandalization committed by adolescents. After mediation, these adolescents agreed to apologize to each of their victims and pay restitution. Several countries (Canada, England, Finland, and the U.S.) have now made this opportunity available in the cases of young offenders. This review describes the process in the south of Israel. We find this method very powerful, but further studies are needed. Due to resource problems, it will not become mainstream in the near future. PMID:17334626

  18. Purley four-dimensional viable anomaly mediation

    International Nuclear Information System (INIS)

    Anomaly mediation of supersymmetry breaking solves the supersymmetric flavor problem thanks to its ultraviolet-insensitivity. However, it suffers from two problems: sleptons have negative masses-squared, and there are likely bulk moduli that spoil the framework. Here, we present the first fully ultraviolet-insensitive model of anomaly mediation with positive slepton masses-squared in a purely four-dimensional framework. Our model is based on the additional D-term contributions to the sparticle masses, and the conformal sequestering mechanism. (author)

  19. A Microscopic Theory of Gauge Mediation

    International Nuclear Information System (INIS)

    We construct models of indirect gauge mediation where the dynamics responsible for breaking supersymmetry simultaneously generates a weakly coupled subsector of messengers. This provides a microscopic realization of messenger gauge mediation where the messenger and hidden sector fields are unified into a single sector. The UV theory is SQCD with massless and massive quarks plus singlets, and at low energies it flows to a weakly coupled quiver gauge theory. One node provides the primary source of supersymmetry breaking, which is then transmitted to the node giving rise to the messenger fields. These models break R-symmetry spontaneously, produce realistic gaugino and sfermion masses, and give a heavy gravitino.

  20. A simple model of direct gauge mediation

    International Nuclear Information System (INIS)

    In the context of direct gauge mediation Wess-Zumino models are very attractive in supersymmetry model building. Besides the spontaneous supersymmetry and R-symmetry breaking, the problems of small gaugino mass as well as μ and Bμ terms should be solved so as to achieve a viable model. In this Letter, we propose a simple model as an existence proof, in which all these subjects are realized simultaneously, with no need of fine tuning. This completion also implies that much of parameter space for direct gauge mediation can be directly explored at LHC.

  1. Markets with Strategic Multi-minded Mediators

    OpenAIRE

    Feldman, Moran; Gonen, Rica

    2016-01-01

    We consider the design of mechanisms for multi-sided exchanges that interact with strategic players-some of which have multi-dimension strategic spaces or are represented by mediators. Players act to optimize their own utilities. The mechanism designer, on the other hand, aims to optimize a social goal, i.e., the gain from trade. As the mediators control the information flow from their players to the mechanism, the mechanism faces strategic behavior not only from the players but also from med...

  2. The Visual What For Area

    DEFF Research Database (Denmark)

    Starrfelt, Randi; Gerlach, Christian

    2007-01-01

    An area in the left fusiform gyrus labelled the Visual Word Form Area (VWFA) is claimed to be especially, or even selectively, responsive to words. We explored how stimulus type and task demands affect activity in this area by conducting a PET experiment where words and pictures were presented in...

  3. Flexible Mediation Analysis in the Presence of Nonlinear Relations: Beyond the Mediation Formula.

    Science.gov (United States)

    Loeys, Tom; Moerkerke, Beatrijs; De Smet, Olivia; Buysse, Ann; Steen, Johan; Vansteelandt, Stijn

    2013-11-01

    In the social sciences, mediation analysis has typically been formulated in the context of linear models using the Baron & Kenny (1986) approach. Extensions to nonlinear models have been considered but lack formal justification. By placing mediation analysis within the counterfactual framework of causal inference one can define causal mediation effects in a way that is not tied to a specific statistical model and identify them under certain no unmeasured confounding assumptions. Corresponding estimation procedures using parametric or nonparametric models, based on the so-called mediation formula, have recently been proposed in the psychological literature and made accessible through the R-package mediation. A number of limitations of the latter approach are discussed and a more flexible approach using natural effects models is proposed as an alternative. The latter builds on the same counterfactual framework but enables interpretable and parsimonious modeling of direct and mediated effects and facilitates tests of hypotheses that would otherwise be difficult or impossible to test. We illustrate the approach in a study of individuals who ended a romantic relationship and explore whether the effect of attachment anxiety during the relationship on unwanted pursuit behavior after the breakup is mediated by negative affect during the breakup. PMID:26745597

  4. Auxin-dependent compositional change in Mediator in ARF7- and ARF19-mediated transcription.

    Science.gov (United States)

    Ito, Jun; Fukaki, Hidehiro; Onoda, Makoto; Li, Lin; Li, Chuanyou; Tasaka, Masao; Furutani, Masahiko

    2016-06-01

    Mediator is a multiprotein complex that integrates the signals from transcription factors binding to the promoter and transmits them to achieve gene transcription. The subunits of Mediator complex reside in four modules: the head, middle, tail, and dissociable CDK8 kinase module (CKM). The head, middle, and tail modules form the core Mediator complex, and the association of CKM can modify the function of Mediator in transcription. Here, we show genetic and biochemical evidence that CKM-associated Mediator transmits auxin-dependent transcriptional repression in lateral root (LR) formation. The AUXIN/INDOLE 3-ACETIC ACID 14 (Aux/IAA14) transcriptional repressor inhibits the transcriptional activity of its binding partners AUXIN RESPONSE FACTOR 7 (ARF7) and ARF19 by making a complex with the CKM-associated Mediator. In addition, TOPLESS (TPL), a transcriptional corepressor, forms a bridge between IAA14 and the CKM component MED13 through the physical interaction. ChIP assays show that auxin induces the dissociation of MED13 but not the tail module component MED25 from the ARF7 binding region upstream of its target gene. These findings indicate that auxin-induced degradation of IAA14 changes the module composition of Mediator interacting with ARF7 and ARF19 in the upstream region of their target genes involved in LR formation. We suggest that this regulation leads to a quick switch of signal transmission from ARFs to target gene expression in response to auxin. PMID:27217573

  5. MPLS for metropolitan area networks

    CERN Document Server

    Tan, Nam-Kee

    2004-01-01

    METROPOLITAN AREA NETWORKS AND MPLSRequirements of Metropolitan Area Network ServicesMetropolitan Area Network OverviewThe Bandwidth DemandThe Metro Service Provider's Business ApproachesThe Emerging Metro Customer Expectations and NeedsSome Prevailing Metro Service OpportunitiesService Aspects and RequirementsRoles of MPLS in Metropolitan Area NetworksMPLS PrimerMPLS ApplicationsTRAFFIC ENGINEERING ASPECTS OF METROPOLITAN AREA NETWORKSTraffic Engineering ConceptsNetwork CongestionHyper Aggregation ProblemEasing CongestionNetwork ControlTactical versus Strategic Traffic EngineeringIP/ATM Overl

  6. STRAWBERRY CRATER ROADLESS AREAS, ARIZONA.

    Science.gov (United States)

    Wolfe, Edward W.; Light, Thomas D.

    1984-01-01

    The results of a mineral survey conducted in the Strawberry Crater Roadless Areas, Arizona, indicate little promise for the occurrence of metallic mineral or fossil fuel resources in the area. The area contains deposits of cinder, useful for the production of aggregate block, and for deposits of decorative stone; however, similar deposits occur in great abundance throughout the San Francisco volcanic field outside the roadless areas. There is a possibility that the Strawberry Crater Roadless Areas may overlie part of a crustal magma chamber or still warm pluton related to the San Francisco Mountain stratovolcano or to basaltic vents of late Pleistocene or Holocene age. Such a magma chamber or pluton beneath the Strawberry Crater Roadless Areas might be an energy source from which a hot-, dry-rock geothermal energy system could be developed, and a probable geothermal resource potential is therefore assigned to these areas. 9 refs.

  7. Fire Hazards Analysis for the 200 Area Interim Storage Area

    International Nuclear Information System (INIS)

    This documents the Fire Hazards Analysis (FHA) for the 200 Area Interim Storage Area. The Interim Storage Cask, Rad-Vault, and NAC-1 Cask are analyzed for fire hazards and the 200 Area Interim Storage Area is assessed according to HNF-PRO-350 and the objectives of DOE Order 5480 7A. This FHA addresses the potential fire hazards associated with the Interim Storage Area (ISA) facility in accordance with the requirements of DOE Order 5480 7A. It is intended to assess the risk from fire to ensure there are no undue fire hazards to site personnel and the public and to ensure property damage potential from fire is within acceptable limits. This FHA will be in the form of a graded approach commensurate with the complexity of the structure or area and the associated fire hazards

  8. Binding of Candida albicans yeast cells to mouse popliteal lymph node tissue is mediated by macrophages.

    OpenAIRE

    Han, Y.; Van Rooijen, N.; Cutler, J E

    1993-01-01

    We previously reported that Candida albicans yeast cells adhere to the macrophage-rich medullary and subcapsular sinus areas of mouse lymph node tissue. To determine whether the yeast cell-lymph node interaction is mediated by macrophages, the effect of specific elimination of macrophages on yeast cell binding was studied, and yeast cell adherence was correlated with the ingestion of India ink by lymph node cells. Macrophage elimination was done by use of liposome-containing dichloromethylene...

  9. Upper Ocean Thermal Responses to Sea Spray Mediated Turbulent Fluxes during Typhoon Passage

    OpenAIRE

    Lianxin Zhang; Changlong Guan; Chunjian Sun; Siyu Gao; Shaomei Yu

    2015-01-01

    A one-dimensional turbulent model is used to investigate the effect of sea spray mediated turbulent fluxes on upper ocean temperature during the passage of typhoon Yagi over the Kuroshio Extension area in 2006. Both a macroscopical sea spray momentum flux algorithm and a microphysical heat and moisture flux algorithm are included in this turbulent model. Numerical results show that the model can well reproduce the upper ocean temperature, which is consistent with the data from the Kuroshio Ex...

  10. Developing a Design Methodology for Web 2.0 Mediated Learning

    OpenAIRE

    Buus, Lillian; Georgsen, Marianne; Ryberg, Thomas; Glud, Louise Nørgaard; Davidsen, Jacob

    2010-01-01

    In this paper we discuss the notion of a learning methodology and situate this within the wider frame of learning design or “Designing for Learning”. We discuss existing work within this broad area by trying to categorize different approaches and interpretations and we present our development of particular ‘mediating design artefacts’. We discuss what can be viewed as a lack of attention paid to integrating the preferred teaching styles and learning philosophies of practitioners into design t...

  11. The detection of Plasmodiophora brassicae using loop-mediated isothermal DNA amplification

    OpenAIRE

    Joanna Kaczmarek; Witold Irzykowski; Adam Burzyński; Małgorzata Jędryczka

    2014-01-01

    Plasmodiophora brassicae, the cause of clubroot, is a very serious problem preventing from successful and profitable cultivation of oilseed rape in Poland. The pathogen was found in all main growing areas of oilseed rape; it also causes considerable problems in growing of vegetable brassicas. The aim of this work was to elaborate fast, cheap and reliable screening method to detect P. brassicae. To achieve this aim the Loop-mediated isothermal DNA amplification (LAMP) technique has been elabor...

  12. Immune Dysfunctlon in Patients With Obstructive Jaundice, Mediators and Implications for Treatments

    OpenAIRE

    W. G. Jiang; Puntis, M. C. A.

    1997-01-01

    Patients with obstructive jaundice have an increased perioperative complication rate. Sepsis, bleeding, wound problems, renal and liver malfunction are all seen in these patients. Assessment of immune function has been an active research area in these patients. This review will examine various aspects of immune functions in obstructive jaundice, discuss the recent research results and controversies and then go on to discuss the relevant mediators of immune function and some possible implicati...

  13. Microneedle-mediated transcutaneous immunization with plasmid DNA coated on cationic PLGA nanoparticles

    OpenAIRE

    Kumar, Amit; Wonganan, Piyanuch; Sandoval, Michael A.; Li, Xinran; Zhu, Saijie; Cui, Zhengrong

    2012-01-01

    Previously, it was shown that microneedle-mediated transcutaneous immunization with plasmid DNA can potentially induce a stronger immune response than intramuscular injection of the same plasmid DNA. In the present study, we showed that the immune responses induced by transcutaneous immunization by applying plasmid DNA onto a skin area pretreated with solid microneedles were significantly enhanced by coating the plasmid DNA on the surface of cationic nanoparticles. In addition, the net surfac...

  14. RNAi-mediated plant protection against aphids.

    Science.gov (United States)

    Yu, Xiu-Dao; Liu, Zong-Cai; Huang, Si-Liang; Chen, Zhi-Qin; Sun, Yong-Wei; Duan, Peng-Fei; Ma, You-Zhi; Xia, Lan-Qin

    2016-06-01

    Aphids (Aphididae) are major agricultural pests that cause significant yield losses of crop plants each year by inflicting damage both through the direct effects of feeding and by vectoring harmful plant viruses. Expression of double-stranded RNA (dsRNA) directed against suitable insect target genes in transgenic plants has been shown to give protection against pests through plant-mediated RNA interference (RNAi). Thus, as a potential alternative and effective strategy for insect pest management in agricultural practice, plant-mediated RNAi for aphid control has received close attention in recent years. In this review, the mechanism of RNAi in insects and the so far explored effective RNAi target genes in aphids, their potential applications in the development of transgenic plants for aphid control and the major challenges in this regard are reviewed, and the future prospects of using plant-mediated RNAi for aphid control are discussed. This review is intended to be a helpful insight into the generation of aphid-resistant plants through plant-mediated RNAi strategy. © 2016 Society of Chemical Industry. PMID:26888776

  15. Nonthermal dark matter in mirage mediation

    International Nuclear Information System (INIS)

    In mirage-mediation models there exists a modulus field whose mass is O(1000) TeV and its late decay may significantly change the standard thermal relic scenario of the dark matter. We study nonthermal production of the dark matter directly from the modulus decay, and find that for some parameter regions nonthermally produced neutralinos can become the dark matter

  16. A Mediated Lifespace: Working Relationally with Girls

    Science.gov (United States)

    Hoskins, Marie L.; Mathieson, Lindsay C.

    2004-01-01

    A lifespace has to do with how selves are mediated by combining multiple cultural symbols to construct an identity in the world. The authors cite examples from media texts, as well as from a narrative study conducted with 10 adolescent girls in a treatment program for eating disorders, that illustrate the importance of practitioners considering…

  17. Causal mediation analyses with rank preserving models.

    Science.gov (United States)

    Have, Thomas R Ten; Joffe, Marshall M; Lynch, Kevin G; Brown, Gregory K; Maisto, Stephen A; Beck, Aaron T

    2007-09-01

    We present a linear rank preserving model (RPM) approach for analyzing mediation of a randomized baseline intervention's effect on a univariate follow-up outcome. Unlike standard mediation analyses, our approach does not assume that the mediating factor is also randomly assigned to individuals in addition to the randomized baseline intervention (i.e., sequential ignorability), but does make several structural interaction assumptions that currently are untestable. The G-estimation procedure for the proposed RPM represents an extension of the work on direct effects of randomized intervention effects for survival outcomes by Robins and Greenland (1994, Journal of the American Statistical Association 89, 737-749) and on intervention non-adherence by Ten Have et al. (2004, Journal of the American Statistical Association 99, 8-16). Simulations show good estimation and confidence interval performance by the proposed RPM approach under unmeasured confounding relative to the standard mediation approach, but poor performance under departures from the structural interaction assumptions. The trade-off between these assumptions is evaluated in the context of two suicide/depression intervention studies. PMID:17825022

  18. IgE-mediated food hypersensitivity disorders.

    Science.gov (United States)

    Gotua, M; Lomidze, N; Dolidze, N; Gotua, T

    2008-04-01

    Food allergy has become a serious health concern especially in developed countries in the past two decades. In general population approximately 4-6% of children and 1-3% of adults experience food allergy. The article reviews IgE-mediated food hypersensitivity disorders. Epidemiology, Mechanism, Clinical manifestations, Genetically modified crops (GMOs), Diagnosis, Prevention and Treatment of IgE-mediated food allergies are discussed. The investigations show that over 90% of IgE-mediated food allergies in childhood are caused by: cow's milk, hen's egg, soy, peanuts, tree nuts, wheat, fish and shellfish. Also the causes of food allergy are food additives, genetically modified crops. Risk factors for food-dependent exercise-induced anaphylaxis include asthma and previous allergic reactions to the causative food. Food allergy is one of the most common causes of systematic anaphylaxis and anaphylactoid reactions, with an annual incidence of four cases per million populations and estimated 500 deaths annually. In addition to gastrointestinal symptoms, individuals may experience urticaria, angioedema, atopic dermatitis, oral syndrome, asthma, rhinitis, conjunctivitis, hypotension, shock and cardiac arrhythmias, caused by the massive release of mediators from mast cells and basophiles. Diagnosis of food allergy is based on history, detailed dietary analysis, skin testing, measuring specific IgE in blood serum and challenge tests. Treatment and prevention includes: avoidance diet, application of auto-injectable epinephrine, H1 and H2 antihistamines, corticosteroids, antileukotrienes, prostaglandin synthetase inhibitors, cromolyn sodium, etc. PMID:18487689

  19. Microbial ecology of bacterially mediated PCB biodegradation

    International Nuclear Information System (INIS)

    The roles of plasmid mediated and consortia mediated polychlorinated biphenyl (PCB) biodegradation by bacterial populations isolated from PCB contaminated freshwater sediments were investigated. PCB degrading bacteria were isolated by DNA:DNA colony hybridization, batch enrichments, and chemostat enrichment. Analysis of substrate removal and metabolite production were done using chlorinated biphenyl spray plates, reverse phase high pressure liquid chromatography, Cl- detection, and 14C-labeled substrate mineralization methods. A bacterial consortium, designated LPS10, involved in a concerted metabolic attack on chlorinated biphenyls, was shown to mineralize 4-chlorobiphenyl (4CB) and 4,4'-dichlorobiphenyl (4,4' CB). The LPS10 consortium was isolated by both batch and chemostat enrichment using 4CB and biphenyl (BP) as sole carbon source and was found to have tree bacterial isolates that predominated; these included: Pseudomonas, testosteroni LPS10A which mediated the breakdown of 4CB and 4,4' CB to the putative meta-cleavage product and subsequently to 4-chlorobenzoic acid (4CBA), an isolate tentatively identified as an Arthrobacter sp. LPS10B which mediated 4CBA degradation, and Pseudomonas putida by A LPS10C whose role in the consortium has not been determined

  20.  Fashion Mediators and Distributed Agency

    DEFF Research Database (Denmark)

    Sommerlund, Julie

    intermediaries" (Bourdieu, 1984) which designates a certain class of people. Empirically, the paper works with the cultural and aesthetic economies - and with fashion in particular. Using the mediator as central concept, the paper presents empirical stories from the field of fashion, and fashion marketing...

  1. Plasmid mediated quinolone resistance in Enterobacteriaceae

    NARCIS (Netherlands)

    Veldman, K.T.

    2014-01-01

    This thesis describes the occurrence of Plasmid Mediated Quinolone Resistance (PMQR) in Salmonella and E. coli from The Netherlands and other European countries. Furthermore, the genetic background of these genes was characterized. Fluoroquinolones are widely used antibiotics in both human and veter

  2. Children and TV II: Mediating the Medium.

    Science.gov (United States)

    Winick, Mariann Pezzella; Wehrenberg, Judith S.

    This guidebook focuses on the reality of children's television viewing and the possibilities open to teachers for mediating the experience to enhance children's development and enrich the school curriculum. A Piagetian framework is used to examine and structure material suitable for the classroom. Part I of the guide reviews the historic…

  3. Multiscale Simulation of Protein Mediated Membrane Remodeling

    OpenAIRE

    Ayton, Gary S.; Voth, Gregory A.

    2009-01-01

    Proteins interacting with membranes can result in substantial membrane deformations and curvatures. This effect is known in its broadest terms as membrane remodeling. This review article will survey current multiscale simulation methodologies that have been employed to examine protein-mediated membrane remodeling.

  4. Extended tree-level gauge mediation

    DEFF Research Database (Denmark)

    Monaco, M.; Nardecchia, M.; Romanino, A.;

    2011-01-01

    Tree-level gauge mediation (TGM) is a scenario of SUSY breaking in which the tree-level exchange of heavy (possibly GUT) vector fields generates flavor-universal sfermion masses. In this work we extend this framework to the case of E(6) that is the natural extension of the minimal case studied so...

  5. Comments: Causal Interpretations of Mediation Effects

    Science.gov (United States)

    Jo, Booil; Stuart, Elizabeth A.

    2012-01-01

    The authors thank Dr. Lindsay Page for providing a nice illustration of the use of the principal stratification framework to define causal effects, and a Bayesian model for effect estimation. They hope that her well-written article will help expose education researchers to these concepts and methods, and move the field of mediation analysis in…

  6. A Comparison of Three Tests of Mediation

    Science.gov (United States)

    Warbasse, Rosalia E.

    2009-01-01

    A simulation study was conducted to evaluate the performance of three tests of mediation: the bias-corrected and accelerated bootstrap (Efron & Tibshirani, 1993), the asymmetric confidence limits test (MacKinnon, 2008), and a multiple regression approach described by Kenny, Kashy, and Bolger (1998). The evolution of these methods is reviewed and…

  7. Holographic gauge mediation via strongly coupled messengers

    International Nuclear Information System (INIS)

    We consider a relative of semidirect gauge mediation where the hidden sector exists at large 't Hooft coupling. Such scenarios can be difficult to describe using perturbative field theory methods but may fall into the class of holographic gauge mediation scenarios, meaning that they are amenable to the techniques of gauge/gravity duality. We use a recently found gravity solution to examine one such case, where the hidden sector is a cascading gauge theory resulting in a confinement scale not much smaller than the messenger mass. In the original construction of holographic gauge mediation, as in other examples of semidirect gauge mediation at strong coupling, the primary contributions to visible sector soft terms come from weakly coupled messenger mesons. In contrast to these examples, we describe the dual of a gauge theory where there are significant contributions from scales in which the strongly coupled messenger quarks are the effective degrees of freedom. In this regime, the visible sector gaugino mass can be calculated entirely from holography.

  8. Peer Mediation and Middle School Students

    Science.gov (United States)

    Calbreath, Wes; Crews, Moody E.

    2011-01-01

    With the constant concern over violence in schools, school officials are looking for ways to head off this potential problem and to better assure a safe environment for all students. One way that has become popular is the implementation of peer mediation programs where students assist other students in learning how to deal with conflict through…

  9. Mediating Artifact in Teacher Professional Development

    Science.gov (United States)

    Svendsen, Bodil

    2015-07-01

    This article focuses on teacher professional development (TPD) in natural science through the 5E model as mediating artifact. The study was conducted in an upper secondary school, grounded in a school-based intervention research project. My contribution to the field of research on TPD is founded on the hypothesis that teachers would be best facilitated to make their practice more inquiry based if they are provided with a mediating artifact. In this study the artifact is a model 5E, which is a conceptual way of thinking, to help teachers reflect on their practice. The aim is to encourage teachers to make changes themselves, by applying extended use of inquiry into their practice. This mediated artifact could thus be used across different national contexts. The main research question is; how can the 5E model as a mediating artifact enhance TPD? The article addresses the processes of the use of the 5E model and its influence on teachers' perception of the model. This is in order for teachers to conceptualize their goals related to inquiry and scientific thinking, and to solve the problems involved in achieving those goals in their own contexts. The study concludes that, after the intervention, the teachers' approaches and strategies demonstrate greater emphasis on learning.

  10. Excursion-Set-Mediated Genetic Algorithm

    Science.gov (United States)

    Noever, David; Baskaran, Subbiah

    1995-01-01

    Excursion-set-mediated genetic algorithm (ESMGA) is embodiment of method of searching for and optimizing computerized mathematical models. Incorporates powerful search and optimization techniques based on concepts analogous to natural selection and laws of genetics. In comparison with other genetic algorithms, this one achieves stronger condition for implicit parallelism. Includes three stages of operations in each cycle, analogous to biological generation.

  11. One-Shot Public Mediated Talk

    OpenAIRE

    Ehud Lehrer; Sylvain Sorin

    1994-01-01

    We show that any correlation device with rational coefficients can be generated by a mechanism where each player sends a private message to a mediator who in turn makes a public deterministic announcement. Moreover, the mechanism suggested is immunized against individual deviations.

  12. Teaching Responsibly with Technology-Mediated Communication

    Science.gov (United States)

    Veltsos, Jennifer R.; Veltsos, Christophe

    2010-01-01

    Technology-mediated communication, or "new media," such as blogs, Twitter, wikis, and social network sites, can be an endless source of ideas for activities or inspiration for classroom discussion. Many instructors ask students to monitor current events by following keywords and industry leaders on Twitter and reading both corporate and trade…

  13. Integrating Computer-Mediated Communication Strategy Instruction

    Science.gov (United States)

    McNeil, Levi

    2016-01-01

    Communication strategies (CSs) play important roles in resolving problematic second language interaction and facilitating language learning. While studies in face-to-face contexts demonstrate the benefits of communication strategy instruction (CSI), there have been few attempts to integrate computer-mediated communication and CSI. The study…

  14. Analyzing the mediated voice - a datasession

    DEFF Research Database (Denmark)

    Lawaetz, Anna

    Broadcasted voices are technologically manipulated. In order to achieve a certain autencity or sound of “reality” paradoxically the voices are filtered and trained in order to reach the listeners. This “mis-en-scene” is important knowledge when it comes to the development of a consistent method of...... analysis of the mediated voice...

  15. Adsorbate-mediated growth of silver nanoparticles

    Czech Academy of Sciences Publication Activity Database

    Šišková, K.; Vlčková, B.; Mojzeš, P.; Šlouf, Miroslav

    Praha : Czech Society for New Materials, Nanoscience and Nanotechnology Section, 2003. s. 19. ISBN 80-214-2486-9. [International Conference 'NANO'. 21.10.2003-23.10.2003, Brno] R&D Projects: GA ČR GA203/01/1013 Institutional research plan: CEZ:AV0Z4050913 Keywords : mediated growth * silver nanoparticles * nanotechnology Subject RIV: CF - Physical ; Theoretical Chemistry

  16. SSL Demonstration: Area Lighting, Yuma Sector Border Patrol Area, AZ

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-05-28

    Along the Yuma Sector Border Patrol Area in Yuma, Arizona, the GATEWAY program conducted a trial demonstration in which the incumbent quartz metal halide area lighting was replaced with LED at three pole locations at the Yuma Sector Border Patrol Area in Yuma, Arizona. The retrofit was documented to better understand LED technology performance in high-temperature environments. This document is a summary brief of the Phase 1.0 and 1.1 reports previously published on this demonstration.

  17. Geographic variation and effect of area-level poverty rate on colorectal cancer screening

    OpenAIRE

    Schootman Mario; Lian Min; Yun Shumei

    2008-01-01

    Abstract Background With a secular trend of increasing colorectal cancer (CRC) screening, concerns about disparities in CRC screening also have been rising. It is unclear if CRC screening varies geographically, if area-level poverty rate affects CRC screening, and if individual-level characteristics mediate the area-level effects on CRC screening. Methods Using 2006 Missouri Behavioral Risk Factor Surveillance System (BRFSS) data, a multilevel study was conducted to examine geographic variati...

  18. Geographic variation and effect of area-level poverty rate on colorectal cancer screening

    Directory of Open Access Journals (Sweden)

    Schootman Mario

    2008-10-01

    Full Text Available Abstract Background With a secular trend of increasing colorectal cancer (CRC screening, concerns about disparities in CRC screening also have been rising. It is unclear if CRC screening varies geographically, if area-level poverty rate affects CRC screening, and if individual-level characteristics mediate the area-level effects on CRC screening. Methods Using 2006 Missouri Behavioral Risk Factor Surveillance System (BRFSS data, a multilevel study was conducted to examine geographic variation and the effect of area-level poverty rate on CRC screening use among persons age 50 or older. Individuals were nested within ZIP codes (ZIP5 areas, which in turn, were nested within aggregations of ZIP codes (ZIP3 areas. Six groups of individual-level covariates were considered as potential mediators. Results An estimated 51.8% of Missourians aged 50 or older adhered to CRC screening recommendations. Nearly 15% of the total variation in CRC screening lay between ZIP5 areas. Persons residing in ZIP5 areas with ≥ 10% of poverty rate had lower odds of CRC screening use than those residing in ZIP5 areas with Conclusion Large geographic variation of CRC screening exists in Missouri. Area-level poverty rate, independent of individual-level characteristics, is a significant predictor of CRC screening, but it only explains a small portion of the geographic heterogeneity of CRC screening. Individual-level factors we examined do not mediate the effect of the area-level poverty rate on CRC screening. Future studies should identify other area- and individual-level characteristics associated with CRC screening in Missouri.

  19. Asynchronous Computer-Mediated Corrective Feedback
And The Correct Use Of Prepositions: Is It Really Effective?

    OpenAIRE

    Seyyed Behrooz HOSSEINI

    2012-01-01

    An area that has recently attracted increasing attention is providing feedback on learners’ writing accuracy through the Internet. However, research in this area has largely focused on synchronous communication, i.e., chatting, with fewer studies assessing asynchronous technologies, i.e., e-mailing. Therefore, this study investigates the effectiveness of asynchronous computer-mediated corrective feedback-explicit and implicit, on increasing the correct use of prepositions. Forty-five Iranian ...

  20. Distinguishing anomaly-mediation from gauge-mediation with a Wino NLSP

    CERN Document Server

    Kribs, G D

    2000-01-01

    A striking consequence of supersymmetry breaking communicated purely via the superconformal anomaly is that the gaugino masses are proportional to the gauge beta functions. This result, however, is not unique to anomaly-mediation. We present examples of ``generalized'' gauge-mediated models with messengers in standard model representations that give nearly identical predictions for the gaugino masses, but positive (mass)^2 for all sleptons. There are remarkable similarities between an anomaly-mediated model with a small additional universal mass added to all scalars and the gauge-mediated models with a long-lived Wino next-to-lightest supersymmetric particle (NLSP), leading to only a small set of observables that provide robust distinguishing criteria. These include ratios of the heaviest to lightest selectrons, smuons, and stops. The sign of the gluino soft mass an unambiguous distinction, but requires measuring a difficult class of one-loop radiative corrections to sparticle interactions. A high precision m...

  1. Chinese semantic processing cerebral areas

    Institute of Scientific and Technical Information of China (English)

    SHAN Baoci; ZHANG Wutian; MA Lin; LI Dejun; CAO Bingli; TANG Yiyuan; WU Yigen; TANG Xiaowei

    2003-01-01

    This study has identified the active cerebral areas of normal Chinese that are associated with Chinese semantic processing using functional brain imaging. According to the traditional cognitive theory, semantic processing is not particularly associated with or affected by input modality. The functional brain imaging experiments were conducted to identify the common active areas of two modalities when subjects perform Chinese semantic tasks through reading and listening respectively. The result has shown that the common active areas include left inferior frontal gyrus (BA 44/45), left posterior inferior temporal gyrus (BA37); the joint area of inferior parietal lobules (BA40) and superior temporal gyrus, the ventral occipital areas and cerebella of both hemispheres. It gives important clue to further discerning the roles of different cerebral areas in Chinese semantic processing.

  2. Mediated electrochemical oxidation of organic wastes using a Co(III) mediator in a neutral electrolyte

    International Nuclear Information System (INIS)

    An electrochemical cell with a Co(III) mediator and neutral pH anolyte provides efficient destruction of organic and mixed wastes. The organic waste is concentrated in the anolyte reservoir, where the cobalt mediator oxidizes the organics and insoluble radioactive species and is regenerated at the anode until all organics are converted to carbon dioxide and destroyed. The neutral electrolyte is non-corrosive, and thus extends the lifetime of the cell and its components. 2 figs

  3. Internal ribosome entry sequence-mediated translation initiation triggers nonsense-mediated decay

    OpenAIRE

    Holbrook, Jill A; Neu-Yilik, Gabriele; Gehring, Niels H; Kulozik, Andreas E.; Hentze, Matthias W.

    2006-01-01

    In eukaryotes, a surveillance pathway known as nonsense-mediated decay (NMD) regulates the abundance of messenger RNAs containing premature termination codons (PTCs). In mammalian cells, it has been asserted that the NMD-relevant first round of translation is special and involves initiation by a specific protein heterodimer, the nuclear cap-binding complex (CBC). Arguing against a requirement for CBC-mediated translation initiation, we show that ribosomal recruitment by the internal ribosomal...

  4. Currency Areas and Monetary Coordination

    OpenAIRE

    Qing Liu; Shouyong Shi

    2006-01-01

    In this paper we integrate the recent development in monetary theory with international finance, in order to examine the coordination between two currency areas in setting long-run inflation. The model determines the value of each currency and the size of each currency area without requiring buyers to use a particular currency to buy a country's goods. We show that the two countries inflate above the Friedman rule in a non-cooperative game. Coordination between the two areas reduces inflation...

  5. Pollen- and seed-mediated transgene flow in commercial cotton seed production fields.

    Directory of Open Access Journals (Sweden)

    Shannon Heuberger

    Full Text Available BACKGROUND: Characterizing the spatial patterns of gene flow from transgenic crops is challenging, making it difficult to design containment strategies for markets that regulate the adventitious presence of transgenes. Insecticidal Bacillus thuringiensis (Bt cotton is planted on millions of hectares annually and is a potential source of transgene flow. METHODOLOGY/PRINCIPAL FINDINGS: Here we monitored 15 non-Bt cotton (Gossypium hirsutum, L. seed production fields (some transgenic for herbicide resistance, some not for gene flow of the Bt cotton cry1Ac transgene. We investigated seed-mediated gene flow, which yields adventitious Bt cotton plants, and pollen-mediated gene flow, which generates outcrossed seeds. A spatially-explicit statistical analysis was used to quantify the effects of nearby Bt and non-Bt cotton fields at various spatial scales, along with the effects of pollinator abundance and adventitious Bt plants in fields, on pollen-mediated gene flow. Adventitious Bt cotton plants, resulting from seed bags and planting error, comprised over 15% of plants sampled from the edges of three seed production fields. In contrast, pollen-mediated gene flow affected less than 1% of the seed sampled from field edges. Variation in outcrossing was better explained by the area of Bt cotton fields within 750 m of the seed production fields than by the area of Bt cotton within larger or smaller spatial scales. Variation in outcrossing was also positively associated with the abundance of honey bees. CONCLUSIONS/SIGNIFICANCE: A comparison of statistical methods showed that our spatially-explicit analysis was more powerful for understanding the effects of surrounding fields than customary models based on distance. Given the low rates of pollen-mediated gene flow observed in this study, we conclude that careful planting and screening of seeds could be more important than field spacing for limiting gene flow.

  6. Small Engine & Accessory Test Area

    Data.gov (United States)

    Federal Laboratory Consortium — The Small Engine and Accessories Test Area (SEATA) facilitates testaircraft starting and auxiliary power systems, small engines and accessories. The SEATA consists...

  7. Runoff estimation in residencial area

    OpenAIRE

    Meire Regina de Almeida Siqueira; Paulo José Maria Filho; Myriam de Fátima Laurindo de Seixas; Marcelo dos Santos Targa; Getulio Teixeira Batista; Nelson Wellausen Dias; Paulo Augusto Romera e Silva

    2013-01-01

    This study aimed to estimate the watershed runoff caused by extreme events that often result in the flooding of urban areas. The runoff of a residential area in the city of Guaratinguetá, São Paulo, Brazil was estimated using the Curve-Number method proposed by USDA-NRCS. The study also investigated current land use and land cover conditions, impermeable areas with pasture and indications of the reforestation of those areas. Maps and satellite images of Residential Riverside I Neighborhood we...

  8. A review of causal estimation of effects in mediation analyses.

    Science.gov (United States)

    Ten Have, Thomas R; Joffe, Marshall M

    2012-02-01

    We describe causal mediation methods for analysing the mechanistic factors through which interventions act on outcomes. A number of different mediation approaches have been presented in the biomedical, social science and statistical literature with an emphasis on different aspects of mediation. We review the different sets of assumptions that allow identification and estimation of effects in the simple case of a single intervention, a temporally subsequent mediator and outcome. These assumptions include various no confounding assumptions including sequential ignorability assumptions and also interaction assumptions involving the treatment and mediator. The understanding of such assumptions is crucial since some can be assessed under certain conditions (e.g. treatment-mediator interactions), whereas others cannot (sequential ignorability). These issues become more complex with multiple mediators and longitudinal outcomes. In addressing these assumptions, we review several causal approaches to mediation analyses. PMID:21163849

  9. Evaluation of peer mediation program in elementary school

    OpenAIRE

    Prgić, Ivan

    2014-01-01

    Since mediation is an alternative form of conflict resolution, which is increasingly employed at schools, the thesis is primarily focused on the mediation process at the Rečica ob Savinji elementary school. One key precondition for successful implementation and development of such programs at schools are thorough evaluation of school mediation programs and research on performance and effects thereof. School and peer mediation programs have mushroomed across the world in recent years; however,...

  10. Experiences with peer mediation on selected primary schools

    OpenAIRE

    Rugelj, Darja

    2011-01-01

    Peer mediation, as an efficient way of confict resolution in primary school, is presented in this diploma paper. The theoretical part exposes the question of education, educational plan, mediation in general, peer mediation and serves as a ground to the empirical research. The purpose of this diploma paper is, first with with theoretical examination of the chosen subject and later with independent research, to determine the frequency of referencing of peer mediation as a proactive and prevent...

  11. Workplace Mediation in Ireland: Bridging the Research-Practice Gap

    OpenAIRE

    Curran, Deridre

    2015-01-01

    The purpose of this article is to present a case for the importance of research in informing mediation practice specifically in the context of the management of workplace conflict in Ireland. The position of mediation within the broader dispute-resolution framework is clarified at the outset and the core mediation process is described. The increasing use of mediation in Ireland and the changing institutional context within which it is conducted are discussed. The importance of research is str...

  12. Runoff estimation in residencial area

    Directory of Open Access Journals (Sweden)

    Meire Regina de Almeida Siqueira

    2013-12-01

    Full Text Available This study aimed to estimate the watershed runoff caused by extreme events that often result in the flooding of urban areas. The runoff of a residential area in the city of Guaratinguetá, São Paulo, Brazil was estimated using the Curve-Number method proposed by USDA-NRCS. The study also investigated current land use and land cover conditions, impermeable areas with pasture and indications of the reforestation of those areas. Maps and satellite images of Residential Riverside I Neighborhood were used to characterize the area. In addition to characterizing land use and land cover, the definition of the soil type infiltration capacity, the maximum local rainfall, and the type and quality of the drainage system were also investigated. The study showed that this neighborhood, developed in 1974, has an area of 792,700 m², a population of 1361 inhabitants, and a sloping area covered with degraded pasture (Guaratinguetá-Piagui Peak located in front of the residential area. The residential area is located in a flat area near the Paraiba do Sul River, and has a poor drainage system with concrete pipes, mostly 0.60 m in diameter, with several openings that capture water and sediments from the adjacent sloping area. The Low Impact Development (LID system appears to be a viable solution for this neighborhood drainage system. It can be concluded that the drainage system of the Guaratinguetá Riverside I Neighborhood has all of the conditions and characteristics that make it suitable for the implementation of a low impact urban drainage system. Reforestation of Guaratinguetá-Piagui Peak can reduce the basin’s runoff by 50% and minimize flooding problems in the Beira Rio neighborhood.

  13. Estimation of mediation effects for zero-inflated regression models.

    Science.gov (United States)

    Wang, Wei; Albert, Jeffrey M

    2012-11-20

    The goal of mediation analysis is to identify and explicate the mechanism that underlies a relationship between a risk factor and an outcome via an intermediate variable (mediator). In this paper, we consider the estimation of mediation effects in zero-inflated (ZI) models intended to accommodate 'extra' zeros in count data. Focusing on the ZI negative binomial models, we provide a mediation formula approach to estimate the (overall) mediation effect in the standard two-stage mediation framework under a key sequential ignorability assumption. We also consider a novel decomposition of the overall mediation effect for the ZI context using a three-stage mediation model. Estimation of the components of the overall mediation effect requires an assumption involving the joint distribution of two counterfactuals. Simulation study results demonstrate low bias of mediation effect estimators and close-to-nominal coverage probability of confidence intervals. We also modify the mediation formula method by replacing 'exact' integration with a Monte Carlo integration method. The method is applied to a cohort study of dental caries in very low birth weight adolescents. For overall mediation effect estimation, sensitivity analysis was conducted to quantify the degree to which key assumption must be violated to reverse the original conclusion. PMID:22714572

  14. 15 CFR 930.114 - Secretarial mediation efforts.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Secretarial mediation efforts. 930.114... MANAGEMENT FEDERAL CONSISTENCY WITH APPROVED COASTAL MANAGEMENT PROGRAMS Secretarial Mediation § 930.114 Secretarial mediation efforts. (a) Following the close of the hearing, the hearing officer shall transmit...

  15. 45 CFR 400.83 - Mediation and fair hearings.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Mediation and fair hearings. 400.83 Section 400.83... Employment § 400.83 Mediation and fair hearings. (a) Mediation—(1) Public/private RCA program. The State must ensure that a mediation period prior to imposition of sanctions is provided to refugees by...

  16. 15 CFR 930.112 - Request for Secretarial mediation.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Request for Secretarial mediation. 930... RESOURCE MANAGEMENT FEDERAL CONSISTENCY WITH APPROVED COASTAL MANAGEMENT PROGRAMS Secretarial Mediation § 930.112 Request for Secretarial mediation. (a) The Secretary or other head of a Federal agency, or...

  17. 29 CFR 1203.3 - Interpretation of mediation agreements.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Interpretation of mediation agreements. 1203.3 Section 1203.3 Labor Regulations Relating to Labor (Continued) NATIONAL MEDIATION BOARD APPLICATIONS FOR SERVICE § 1203.3 Interpretation of mediation agreements. (a) Applications may be filed with the Board's Chief...

  18. 7 CFR 900.103 - Application for mediation.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Application for mediation. 900.103 Section 900.103 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... Application for mediation. An application for mediation by a cooperative, shall be in writing and...

  19. Mediation in civiele en bestuursrechtelijke zaken: Een internationaal literatuuronderzoek

    OpenAIRE

    Baas, N.

    2002-01-01

    Doel van dit onderzoek is een overzicht krijgen van vormen van mediation van civiel- en bestuursrechtelijke zaken in binnen- en buitenland, de effectiviteit en efficientie van mediation-projecten en de factoren die van invloed zijn op de effectiviteit en efficiency van mediation.

  20. 29 CFR 1202.2 - Interpretation of mediation agreements.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Interpretation of mediation agreements. 1202.2 Section 1202.2 Labor Regulations Relating to Labor (Continued) NATIONAL MEDIATION BOARD RULES OF PROCEDURE § 1202.2 Interpretation of mediation agreements. Under section 5, Second, of title I of the Railway...