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Sample records for areas mediating motion-induced

  1. Gamma-aminobutyric acid (GABA) and neuropeptides in neural areas mediating motion-induced emesis

    Science.gov (United States)

    Damelio, F.; Daunton, Nancy G.; Fox, Robert A.

    1991-01-01

    Immunocytochemical methods were employed to localize the neurotransmitter amino acid gamma-aminobutyric acid and the neuropeptides substance P and Met-enkephalin in the area postrema (AP), area subpostrema (ASP), nucleus of the tractus solitarius (NTS), dorsal motor nucleus of the vagus nerve (DMNV), and lateral vestibular nucleus (LVN). Glutamic acid decarboxylase immunoreactive (GAD-IR) terminals and fibers were observed in the AP and particularly in the ASP. A gradual decrease in the density of terminals was seen towards the solitary complex. The DMNV revealed irregularly scattered GAD-IR terminals within the neuropil or closely surrounding neuronal cell bodies. The LVN, particularly the dorsal division, showed numerous axon terminals which were mostly localize around large neurons and their proximal dendrites. Substance P immunoreactive (SP-IR) terminals and fibers showed high density in the solitary complex, in particular within the lateral division. The ASP showed medium to low density of SP-IR fibers and terminals. The AP exhibited a small number of fibers and terminals irregularly distributed. The DMNV revealed a high density of SP-IR terminals and fibers that were mainly concentrated in the periphery. Very few terminals were detected in the LVN. Met-enkephalin immunoreactive (Met-Enk-IR) fibers and terminals showed high density and uniform distribution in the DMNV. Scattered terminals and fibers were observed in the AP, ASP, and NTS (particularly the lateral division). The very few fibers were observed in the LVN surrounded the neuronal cell bodies. The present report is part of a study designed to investigate the interaction between neuropeptides and conventional neurotransmitters under conditions producing motion sickness and in the process of sensory-motor adaptation.

  2. Attentional modulation of motion-induced blindness

    Institute of Scientific and Technical Information of China (English)

    GENG HaiYan; SONG QianLan; LI YunFeng; XU Shan; ZHU Ying

    2007-01-01

    When a global moving pattern is superimposed on high-contrast stationary or slowly moving stimuli,the stimuli can be perceived as disappearing and reappearing alternately for periods of several seconds. This visual illusory phenomenon was named "motion-induced blindness" (MIB) in recent literature. So far there is no consensus on the mechanism of MIB, especially on the role of attention in this phenomenon. To examine the effect of spatial attention on MIB, the present study manipulated the participants' spatial attention by asking them to respond to two targets simultaneously presented in bilateral visual fields (the divided-attention condition) or only respond to one of them (the focused-attention condition). A central arrow was presented as an endogenous cue to index the target visual field in the focused-attention condition, while a point was presented instead in the divided-attention condition. The results show that the percentage of accumulated invisibility period was larger for the targets in the focused-attention condition than for those in the divided-attention condition.This effect of attentionis significant in upper visual field (UVF) and left lower visual field (left LVF); that is, this effect shows a hemispheric asymmetry in LVF but not in UVF. Furthermore, the percentage of accumulated invisibility period was larger for targets in left LVF than for those in right LVF in the focused-attention condition, but no hemispheric asymmetry was found in the divided-attention condition.In addition, the increased percentage of accumulated invisibility period in the focused-attention condition originated merely in the enhancement of the mean phase duration of disappearance in LVF, while the disappearance occurred more frequently and lasted longer for each occurrence, which led to an increase in the total invisibility period, in the focused- than divided-attention condition in UVF. These results suggest that the modulation of spatial attention on MIB has different

  3. Radiometric resolution of motion-induced synthetic aperture radiometer

    OpenAIRE

    Hyuk, Park; Camps Carmona, Adriano José; Choi, Min Gyu; Kim, Yong-Hoon

    2011-01-01

    The radiometric resolution of a motion-induced synthetic aperture radiometer (MISAR) is analytically obtained from the standard deviation of a baseline response, an observation scenario, and the imaging method of the MISAR. The intrinsic long integration time given by the whole dwell time on moving platforms improves the radiometric resolution compared with the snapshot resolution of other nominal synthetic aperture radiometers. In addition, it is illustrated that the MISAR imaging hold...

  4. Attentional influences on the dynamics of motion-induced blindness

    OpenAIRE

    Scholvinck, M. L.; Rees, G.

    2009-01-01

    Motion-induced blindness (MIB) is a visual phenomenon in which a highly salient, peripheral, visual target spontaneously disappears from visual awareness (and subsequently reappears) when superimposed on a globally moving background of distracters. Here, we investigated the influence of attention on these fluctuations in perception in two experiments. In the first experiment, directing spatial attention to the MIB target (and thus away from the distracters) led to an increased probability of ...

  5. Motion-induced dose artifacts in helical tomotherapy

    Science.gov (United States)

    Kim, Bryan; Chen, Jeff; Kron, Tomas; Battista, Jerry

    2009-10-01

    Tumor motion is a particular concern for a complex treatment modality such as helical tomotherapy, where couch position, gantry rotation and MLC leaf opening all change with time. In the present study, we have investigated the impact of tumor motion for helical tomotherapy, which could result in three distinct motion-induced dose artifacts, namely (1) dose rounding, (2) dose rippling and (3) IMRT leaf opening asynchronization effect. Dose rounding and dose rippling effects have been previously described, while the IMRT leaf opening asynchronization effect is a newly discovered motion-induced dose artifact. Dose rounding is the penumbral widening of a delivered dose distribution near the edges of a target volume along the direction of tumor motion. Dose rippling is a series of periodic dose peaks and valleys observed within the target region along the direction of couch motion, due to an asynchronous interplay between the couch motion and the longitudinal component of tumor motion. The IMRT leaf opening asynchronization effect is caused by an asynchronous interplay between the temporal patterns of leaf openings and tumor motion. The characteristics of each dose artifact were investigated individually as functions of target motion amplitude and period for both non-IMRT and IMRT helical tomotherapy cases, through computer simulation modeling and experimental verification. The longitudinal dose profiles generated by the simulation program agreed with the experimental data within ±0.5% and ±1.5% inside the PTV region for the non-IMRT and IMRT cases, respectively. The dose rounding effect produced a penumbral increase up to 20.5 mm for peak-to-peak target motion amplitudes ranging from 1.0 cm to 5.0 cm. Maximum dose rippling magnitude of 25% was calculated, when the target motion period approached an unusually high value of 10 s. The IMRT leaf opening asynchronization effect produced dose differences ranging from -29% to 7% inside the PTV region. This information on

  6. Mediation a Conflict Solving Modality in the Banking Area

    Directory of Open Access Journals (Sweden)

    George MĂGUREANU

    2015-08-01

    Full Text Available The overall objective of the paper is a current topic of a real interest for the reasonable solution of the conflicts which emerge in the banking area. Using the method resulted from a detailed analysis of the field literature and the judiciary practice, the article manages to identify the amplitude and generic principles of solving the litigations in the commercial area through alternative methods to the state justice, overcharged with cases, within the context of the European Union’s regulations and implicitly at the national level. Therefore, we shall perform an analysis of the following objectives: the concept of conflict solving through alternative methods to the state justice, reasonable solution of the conflicts with the possibility of preserving the relations between the partners, the application of the privacy principle. Mediation in the banking area aims at solving the conflicts between the credit institutions, banks or the non-banking institutions and their customers by a person with a special training in the mediation area, independent from the two parties, through a more simplified procedure, so that the relation between the credit unit and its customer should remain a partnership. The paper may contribute to the development of the legislation on the more rapid resolution of this type of litigations; it is useful for the law practitioners: judges, lawyers, counsels, teaching staff and also for the business people in the banking area.

  7. A Framework for Content Area Writing: Mediators and Moderators

    Directory of Open Access Journals (Sweden)

    Perry D. Klein

    2010-03-01

    Full Text Available Writing can be a tool for communicating and learning in content area subjects. This pretest-posttest quasi-experiment examined the effects of instruction in a content area writing framework on students’ text quality and ability to use writing to learn. It also examined the effects of possible moderator variables (gender, previous writing achievement and mediator variables (genre knowledge, approach to writing. A multilevel analysis was conducted with students nested within classes. Instruction significantly increased argument genre knowledge and explanation text quality, but not argument text quality, explanation genre knowledge, or learning during writing. Gender predicted previous writing achievement and posttest argument text quality, but did not interact significantly with instruction. Previous writing achievement strongly affected several posttest measures, but did not interact significantly with instruction. A path analysis supported the theory that instruction affects genre knowledge, which affects text quality, which predicts learning during writing.

  8. Analysis of the Possibility and Limitation of Criminal Mediation in Rural Areas in China

    Directory of Open Access Journals (Sweden)

    Hao Guo

    2014-04-01

    Full Text Available With the development in the theory and practice in the area of criminal law in China, a lot of creative views have been put into legal practice. Criminal mediation, which is cropping up in both practice and theory becomes a hot subject under discussion in the field of legislation. The newly modified criminal law formally prescribes the criminal mediation, which has been recognized in the level of law-making. It has become a basic policy in the procedure of law suit. This thesis emphasizes the possibility of criminal mediation in rural areas in China, discussing the disadvantages of the current criminal justice mode, the advantages of criminal mediation and the tradition in rural areas in China. Additionally, it attempts to set up the limitation of criminal mediation, based on the principle of law, principle of equality, principle of utility and principle of justice.

  9. Motion-induced phase error estimation and correction in 3D diffusion tensor imaging.

    Science.gov (United States)

    Van, Anh T; Hernando, Diego; Sutton, Bradley P

    2011-11-01

    A multishot data acquisition strategy is one way to mitigate B0 distortion and T2∗ blurring for high-resolution diffusion-weighted magnetic resonance imaging experiments. However, different object motions that take place during different shots cause phase inconsistencies in the data, leading to significant image artifacts. This work proposes a maximum likelihood estimation and k-space correction of motion-induced phase errors in 3D multishot diffusion tensor imaging. The proposed error estimation is robust, unbiased, and approaches the Cramer-Rao lower bound. For rigid body motion, the proposed correction effectively removes motion-induced phase errors regardless of the k-space trajectory used and gives comparable performance to the more computationally expensive 3D iterative nonlinear phase error correction method. The method has been extended to handle multichannel data collected using phased-array coils. Simulation and in vivo data are shown to demonstrate the performance of the method. PMID:21652284

  10. Freezing motion-induced dephasing in an atomic-ensemble quantum memory

    CERN Document Server

    Jiang, Yan; Bao, Xiao-Hui; Pan, Jian-Wei

    2016-01-01

    Motion-induced dephasing is a dominant decoherence mechanism for atom-gas quantum memories. In this paper, we develop a new coherent manipulation technique which enables arbitrary engineering of the spin-wave momentum with neglectable noise. By zeroing the spin-wave momentum, motion-induced dephasing can be frozen completely. We experimentally demonstrate this scheme with laser-cooled atoms in a DLCZ configuration. By applying the freezing pulses, memory lifetime gets extended significantly to the limit of atom cloud expansion and does not depend on the detection angle anymore. The observed high cross-correlation above 20 proves that high-fidelity memory operation is well preserved after coherent manipulation.

  11. Motion-induced blindness and Troxler fading: common and different mechanisms

    OpenAIRE

    Bonneh, Yoram S.; Donner, Tobias H.; Alexander Cooperman; Heeger, David J.; Dov Sagi

    2014-01-01

    Extended stabilization of gaze leads to disappearance of dim visual targets presented peripherally. This phenomenon, known as Troxler fading, is thought to result from neuronal adaptation. Intense targets also disappear intermittently when surrounded by a moving pattern (the "mask"), a phenomenon known as motion-induced blindness (MIB). The similar phenomenology and dynamics of these disappearances may suggest that also MIB is, likewise, solely due to adaptation, which may be amplified by the...

  12. Action spectroscopy for single-molecule motion induced by vibrational excitation with a scanning tunneling microscope

    OpenAIRE

    Ueba, H.; Persson, B.N.J.

    2007-01-01

    We propose an action spectroscopy for single-molecule motion induced by vibrational excitation with a scanning tunneling microscope (STM). Calculations of the inelastic tunneling current for excitation of the C-O stretch mode of the CO molecule on metal surfaces are combined with a theory which describes how the energy in the vibrational mode is transferred to a reaction coordinate mode to overcome the activation barrier. The calculated rate for CO hopping on Pd (110) as a function of the bia...

  13. Patient-specific quantification of respiratory motion-induced dose uncertainty for step-and-shoot IMRT of lung cancer

    OpenAIRE

    Li, Heng; Park, Peter; Liu, Wei; Matney, Jason; Liao, Zhongxing; Balter, Peter; Li, Yupeng; Zhang, Xiaodong; Li, Xiaoqiang; Zhu, X. Ronald

    2013-01-01

    Purpose: The objective of this study was to quantify respiratory motion-induced dose uncertainty at the planning stage for step-and-shoot intensity-modulated radiation therapy (IMRT) using an analytical technique.

  14. Freezing motion-induced dephasing for single spin-state stored in atomic ensemble

    Science.gov (United States)

    Jiang, Yan; Jun, Rui; Bao, Xiao-Hui; Pan, Jian-Wei

    2016-05-01

    Atomic-ensemble quantum memories are well considered as a promising approach of long-distance quantum communication and computation for strong light-matter interaction. While the storage lifetime is limited by the motion-induced dephasing. Spin-echo technique, increasing wavelength of spin-wave, as well as optical lattice are used commonly to overcome this dephasing process. However, these techniques either need extremely high fidelity of echo pulse or put high restriction on filter and experimental complexity. In this poster, we demonstrate a convenient technique to freeze the motion-induced dephasing without population inversion and can be used in large storage angles. Combined with ``clock states'', the lifetime is extended by one order of magnitude to the limit of the thermal expansion. What's more, high non-classical correlation above 20 has been achieved to guarantee the memory in quantum regime.By making the advance from passive engineering to coherent manipulation of single spin-wave states, our work enriches the experimental toolbox of harnessing atomic ensembles for high-performance quantum memories, especially for holographic quantum memories where many spin-waves with different wave-vectors are used.

  15. Motion-induced blindness and Troxler fading: common and different mechanisms.

    Directory of Open Access Journals (Sweden)

    Yoram S Bonneh

    Full Text Available Extended stabilization of gaze leads to disappearance of dim visual targets presented peripherally. This phenomenon, known as Troxler fading, is thought to result from neuronal adaptation. Intense targets also disappear intermittently when surrounded by a moving pattern (the "mask", a phenomenon known as motion-induced blindness (MIB. The similar phenomenology and dynamics of these disappearances may suggest that also MIB is, likewise, solely due to adaptation, which may be amplified by the presence of the mask. Here we directly compared the dependence of both phenomena on target contrast. Observers reported the disappearance and reappearance of a target of varying intensity (contrast levels: 8%-80%. MIB was induced by adding a mask that moved at one of various different speeds. The results revealed a lawful effect of contrast in both MIB and Troxler fading, but with opposite trends. Increasing target contrast increased (doubled the rate of disappearance events for MIB, but decreased the disappearance rate to half in Troxler fading. The target mean invisible period decreased equally strongly with target contrast in MIB and in Troxler fading. The results suggest that both MIB and Troxler are equally affected by contrast adaptation, but that the rate of MIB is governed by an additional mechanism, possibly involving antagonistic processes between neuronal populations processing target and mask. Our results link MIB to other bi-stable visual phenomena that involve neuronal competition (such as binocular rivalry, which exhibit an analogous dependency on the strength of the competing stimulus components.

  16. Motion-induced blindness and Troxler fading: common and different mechanisms.

    Science.gov (United States)

    Bonneh, Yoram S; Donner, Tobias H; Cooperman, Alexander; Heeger, David J; Sagi, Dov

    2014-01-01

    Extended stabilization of gaze leads to disappearance of dim visual targets presented peripherally. This phenomenon, known as Troxler fading, is thought to result from neuronal adaptation. Intense targets also disappear intermittently when surrounded by a moving pattern (the "mask"), a phenomenon known as motion-induced blindness (MIB). The similar phenomenology and dynamics of these disappearances may suggest that also MIB is, likewise, solely due to adaptation, which may be amplified by the presence of the mask. Here we directly compared the dependence of both phenomena on target contrast. Observers reported the disappearance and reappearance of a target of varying intensity (contrast levels: 8%-80%). MIB was induced by adding a mask that moved at one of various different speeds. The results revealed a lawful effect of contrast in both MIB and Troxler fading, but with opposite trends. Increasing target contrast increased (doubled) the rate of disappearance events for MIB, but decreased the disappearance rate to half in Troxler fading. The target mean invisible period decreased equally strongly with target contrast in MIB and in Troxler fading. The results suggest that both MIB and Troxler are equally affected by contrast adaptation, but that the rate of MIB is governed by an additional mechanism, possibly involving antagonistic processes between neuronal populations processing target and mask. Our results link MIB to other bi-stable visual phenomena that involve neuronal competition (such as binocular rivalry), which exhibit an analogous dependency on the strength of the competing stimulus components. PMID:24658600

  17. Pulsed Rydberg four-wave mixing with motion-induced dephasing in a thermal vapor

    CERN Document Server

    Chen, Yi-Hsin; Löw, Robert; Pfau, Tilman

    2015-01-01

    We report on time-resolved pulsed four-wave mixing (FWM) signals in a thermal Rubidium vapor involving a Rydberg state. We observe FWM signals with dephasing times up to 7 ns, strongly dependent on the excitation bandwidth to the Rydberg state. The excitation to the Rydberg state is driven by a pulsed two-photon transition on ns time scales. Combined with a third cw de-excitation laser, a strongly directional and collective emission is generated according to a combination of the phase matching effect and averaging over Doppler classes. In contrast to a previous report [1] using off-resonant FWM, at a resonant FWM scheme we observe additional revivals of the signal shortly after the incident pulse has ended. We infer that this is a revival of motion-induced constructive interference between the coherent emissions of the thermal atoms. The resonant FWM scheme reveals a richer temporal structure of the signals, compared to similar, but off-resonant excitation schemes. A simple explanation lies in the selectivity...

  18. Simulation by using the lattice Boltzmann method of microscopic particle motion induced by artificial cilia

    Science.gov (United States)

    Alapati, Suresh; Che, Woo Seong; Mannoor, Madhusoodanan; Suh, Yong Kweon

    2016-06-01

    In this paper, we present the results obtained from the simulation of particle motion induced by the fluid flow driven by an array of beating artificial cilia inside a micro-channel. A worm-like-chain model is used to simulate the elastic cilia, and the lattice Boltzmann equation is used to compute the fluid flow. We employ a harmonic force at the extreme tip of each cilium to actuate it. Our simulation methods are first validated by applying them to the motion of a single cilium and a freely falling sphere. After validation, we simulate the fluid flow generated by an array of beating cilia and find that a maximum flow rate is achieved at an optimum sperm number. Next, we simulate the motion of a neutrally buoyant spherical particle at this optimum sperm number by tracking the particle motion with a smoothed profile method. We address the effect of the following parameters on the particle velocity: the gap between cilia and particle, the particle size, the cilia density, and the presence of an array of intermediate particles.

  19. Strategies for reducing intra-fraction motion induced dosimetric effects in proton therapy

    Science.gov (United States)

    Zhao, Li

    Intra-fraction respiration motion during radiation delivery presents a major challenge to radiation therapy. There has been a growing effort to characterize and manage internal organ motion in radiation therapy, however very few studies focus on tackling this issue in proton therapy. Current practice for treating lung tumors in proton therapy is still to apply population-based margins to account for internal tumor motion, which can lead to target underdosage and normal tissue overdosage. This thesis explores the intra-fraction motion induced dosimetric effects from both computational treatment planning and experimental studies. Four-dimensional CT scans are used to analyze the patient-specific tumor motion characteristics. A feasible method to design the range compensator by using the maximum intensity projection (MIP) images is proposed. Results demonstrate that this MIP approach ensures adequate tumor coverage throughout the entire respiratory cycle whilst maintaining normal tissue dose under clinical constraints. Based on 4D-CT scans, dose convolution is used for assessing the accuracy of Gaussian probability density function for modeling the patient-specific respiratory motion on dose distribution. Non-negligible dose discrepancy is observed in comparisons of convolved dose distributions, and patient-specific respiration PDF is advocated. In addition, an experimental phantom study primarily focusing on the interplay effect between target motion and the scanning beam motion is implemented in two proton beam delivery systems: double scattering and uniform scanning. Measurement results suggest that dose blurring effect is dominant, and interplay effect is trivial in the uniform scanning system due to dose repainting.

  20. Patient-specific quantification of respiratory motion-induced dose uncertainty for step-and-shoot IMRT of lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Li, Heng; Park, Peter; Liu, Wei; Matney, Jason; Balter, Peter; Zhang, Xiaodong; Li, Xiaoqiang; Zhu, X. Ronald [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States); Liao, Zhongxing [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States); Li, Yupeng [Applied Research, Varian Medical Systems, Palo Alto, California 94304 (United States)

    2013-12-15

    Purpose: The objective of this study was to quantify respiratory motion-induced dose uncertainty at the planning stage for step-and-shoot intensity-modulated radiation therapy (IMRT) using an analytical technique.Methods: Ten patients with stage II/III lung cancer who had undergone a planning four-dimensional (4D) computed tomographic scan and step-and-shoot IMRT planning were selected with a mix of motion and tumor size for this retrospective study. A step-and-shoot IMRT plan was generated for each patient. The maximum and minimum doses with respiratory motion were calculated for each plan, and the mean deviation from the 4D dose was calculated, taking delivery time, fractionation, and patient breathing cycle into consideration.Results: For all patients evaluated in this study, the mean deviation from the 4D dose in the planning target volume (PTV) was <2.5%, with a standard deviation <1.2%, and maximum point dose variation from the 4D dose was <6.2% in the PTV assuming delivery dose rate of 200 MU/min and patient breathing cycle of 8 s. The motion-induced dose uncertainty is a function of motion, fractionation, MU (plan modulation), dose rate, and patient breathing cycle.Conclusions: Respiratory motion-induced dose uncertainty varies from patient to patient. Therefore, it is important to evaluate the dose uncertainty on a patient-specific basis, which could be useful for plan evaluation and treatment strategy determination for selected patients.

  1. Patient-specific quantification of respiratory motion-induced dose uncertainty for step-and-shoot IMRT of lung cancer

    International Nuclear Information System (INIS)

    Purpose: The objective of this study was to quantify respiratory motion-induced dose uncertainty at the planning stage for step-and-shoot intensity-modulated radiation therapy (IMRT) using an analytical technique.Methods: Ten patients with stage II/III lung cancer who had undergone a planning four-dimensional (4D) computed tomographic scan and step-and-shoot IMRT planning were selected with a mix of motion and tumor size for this retrospective study. A step-and-shoot IMRT plan was generated for each patient. The maximum and minimum doses with respiratory motion were calculated for each plan, and the mean deviation from the 4D dose was calculated, taking delivery time, fractionation, and patient breathing cycle into consideration.Results: For all patients evaluated in this study, the mean deviation from the 4D dose in the planning target volume (PTV) was <2.5%, with a standard deviation <1.2%, and maximum point dose variation from the 4D dose was <6.2% in the PTV assuming delivery dose rate of 200 MU/min and patient breathing cycle of 8 s. The motion-induced dose uncertainty is a function of motion, fractionation, MU (plan modulation), dose rate, and patient breathing cycle.Conclusions: Respiratory motion-induced dose uncertainty varies from patient to patient. Therefore, it is important to evaluate the dose uncertainty on a patient-specific basis, which could be useful for plan evaluation and treatment strategy determination for selected patients

  2. Hypoxia-induced hypothermia mediated by GABA in the rostral parapyramidal area of the medulla oblongata.

    Science.gov (United States)

    Osaka, T

    2014-05-16

    Hypoxia evokes a regulated decrease in the body core temperature (Tc) in a variety of animals. The neuronal mechanisms of this response include, at least in part, glutamatergic activation in the lateral preoptic area (LPO) of the hypothalamus. As the sympathetic premotor neurons in the medulla oblongata constitute a cardinal relay station in the descending neuronal pathway from the hypothalamus for thermoregulation, their inhibition can also be critically involved in the mechanisms of the hypoxia-induced hypothermia. Here, I examined the hypothesis that hypoxia-induced hypothermia is mediated by glutamate-responsive neurons in the LPO that activate GABAergic transmission in the rostral raphe pallidus (rRPa) and neighboring parapyramidal region (PPy) of the medulla oblongata in urethane-chloralose-anesthetized, neuromuscularly blocked, artificially ventilated rats. Unilateral microinjection of GABA (15nmol) into the rRPa and PPy regions elicited a prompt increase in tail skin temperature (Ts) and decreases in Tc, oxygen consumption rate (VO2), and heart rate. Next, when the GABAA receptor blocker bicuculline methiodide (bicuculline methiodide (BMI), 10pmol) alone was microinjected into the rRPa, it elicited unexpected contradictory responses: simultaneous increases in Ts, VO2 and heart rate and a decrease in Tc. Then, when BMI was microinjected bilaterally into the PPy, no direct effect on Ts was seen; and thermogenic and tachycardic responses were slight. However, pretreatment of the PPy with BMI, but not vehicle saline, greatly attenuated the hypothermic responses evoked by hypoxic (10%O2-90%N2, 5min) ventilation or bilateral microinjections of glutamate (5nmol, each side) into the LPO. The results suggest that hypoxia-induced hypothermia was mediated, at least in part, by the activation of GABAA receptors in the PPy. PMID:24607346

  3. A template-free solvent-mediated synthesis of high surface area boron nitride nanosheets for aerobic oxidative desulfurization.

    Science.gov (United States)

    Wu, Peiwen; Zhu, Wenshuai; Chao, Yanhong; Zhang, Jinshui; Zhang, Pengfei; Zhu, Huiyuan; Li, Changfeng; Chen, Zhigang; Li, Huaming; Dai, Sheng

    2016-01-01

    Hexagonal boron nitride nanosheets (h-BNNs) with rather high specific surface area (SSA) are important two-dimensional layer-structured materials. Here, a solvent-mediated synthesis of h-BNNs revealed a template-free lattice plane control strategy that induced high SSA nanoporous structured h-BNNs with outstanding aerobic oxidative desulfurization performance. PMID:26502800

  4. The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking.

    Science.gov (United States)

    Li, Jin; Cui, Yue; Wu, Karen; Liu, Bing; Zhang, Yun; Wang, Chao; Jiang, Tianzi

    2015-08-15

    Novelty seeking (NS) is a personality trait important for adaptive functioning, but an excessive level of NS has been linked to psychiatric disorders such as ADHD and substance abuse. Previous research has investigated separately the neural and genetic bases of the NS trait, but results were mixed and neural and genetic bases have yet to be examined within the same study. In this study, we examined the interrelationships among the dopamine beta-hydroxylase (DBH) gene, brain structure, and the NS trait in 359 healthy Han Chinese subjects. We focused on the DBH gene because it encodes a key enzyme for dopamine metabolism, NS is believed to be related to the dopaminergic system and has been reported associated with DBH variation. Results showed a significant positive association between the cortical surface area of the left insula and NS score. Furthermore, the DBH genetic polymorphism at the SNP rs7040170 was strongly associated with both the surface area of the left insula and NS score, with G carriers having a larger left insula surface area and a higher NS score than AA homozygotes. Subsequent path analysis suggested that the insula partially mediated the association between the DBH gene and the NS trait. Our data provided the first evidence for the involvement of the insula in the dopamine-NS relationship. Future studies of molecular mechanisms underlying the NS personality trait and related psychiatric disorders should consider the mediation effect of the neural structure. PMID:26003854

  5. Prevention of motion-induced signal loss in diffusion-weighted echo-planar imaging by dynamic restoration of gradient moments

    NARCIS (Netherlands)

    Gumus, Kazim; Keating, Brian; Poser, Benedikt A; Armstrong, Brian; Chang, Linda; Maclaren, Julian; Prieto, Thomas; Speck, Oliver; Zaitsev, Maxim; Ernst, Thomas

    2014-01-01

    PURPOSE: Head motion is a significant problem in diffusion-weighted imaging as it may cause signal attenuation due to residual dephasing during strong diffusion encoding gradients even in single-shot acquisitions. Here, we present a new real-time method to prevent motion-induced signal loss in DWI o

  6. Multi-Hazard Analysis for the Estimation of Ground Motion Induced by Landslides and Tectonics

    Science.gov (United States)

    Iglesias, Rubén; Koudogbo, Fifame; Ardizzone, Francesca; Mondini, Alessandro; Bignami, Christian

    2016-04-01

    Space-borne synthetic aperture radar (SAR) sensors allow obtaining all-day all-weather terrain complex reflectivity images which can be processed by means of Persistent Scatterer Interferometry (PSI) for the monitoring of displacement episodes with extremely high accuracy. In the work presented, different PSI strategies to measure ground surface displacements for multi-scale multi-hazard mapping are proposed in the context of landslides and tectonic applications. This work is developed in the framework of ESA General Studies Programme (GSP). The present project, called Multi Scale and Multi Hazard Mapping Space based Solutions (MEMpHIS), investigates new Earth Observation (EO) methods and new Information and Communications Technology (ICT) solutions to improve the understanding and management of disasters, with special focus on Disaster Risk Reduction rather than Rapid Mapping. In this paper, the results of the investigation on the key processing steps for measuring large-scale ground surface displacements (like the ones originated by plate tectonics or active faults) as well as local displacements at high resolution (like the ones related with active slopes) will be presented. The core of the proposed approaches is based on the Stable Point Network (SPN) algorithm, which is the advanced PSI processing chain developed by ALTAMIRA INFORMATION. Regarding tectonic applications, the accurate displacement estimation over large-scale areas characterized by low magnitude motion gradients (3-5 mm/year), such as the ones induced by inter-seismic or Earth tidal effects, still remains an open issue. In this context, a low-resolution approach based in the integration of differential phase increments of velocity and topographic error (obtained through the fitting of a linear model adjustment function to data) will be evaluated. Data from the default mode of Sentinel-1, the Interferometric Wide Swath Mode, will be considered for this application. Regarding landslides

  7. Surface motion induced by nuclear explosions beneath Pahute Mesa. Part I. Halfbreak, Greeley, Scotch, Boxcar events

    International Nuclear Information System (INIS)

    Results of surface motion studies conducted by Sandia Laboratories during seven underground nuclear explosions detonated beneath Pahute Mesa, Areas 19 and 20 of the Nevada Test Site, between 1966 and 1973 are reported. The report is divided into two parts of which this, Part I, includes (1) descriptions of the Pahute Mesa geological environment and of the purposes and instrumentation used in these programs (Chapter 1), and (2) description of four events, the data derived from each, and analysis of these data. These Part I events are HALFBEAK (Chapter 2), GREELEY (Chapter 3), SCOTCH (Chapter 4), and BOXCAR (Chapter 5) for all of which a nominally radial array of gage stations yielded data as a function of distance primarily, although in a few cases data were derived from stations at widely separated azimuths from the explosion. Results of the analysis indicate that average propagation velocity through the geologic column between the explosions and mesa surface was about 8800 ft/sec and that for horizontal distances greater than shot depth, refraction occurred within rhyolite flows with characteristic velocity of about 12,300 ft/sec. There is evidence which suggests possible deeper refraction at a velocity between 18,000 and 21,000 ft/sec. Only the verticle motion peaks follow a pattern amenable to regression analysis because geometrical effects influence horizontal motion amplitudes differently as horizontal distances increase. Particle velocities vary roughly as the inverse square of slant or radial range with exponent values ranging from -3.9 to -1.3. Displacements follow a similar pattern with exponents ranging from about -6 to -2. Displacement profiles at various times during the motion and displacement hodographs in the vertical-radial plane aid in understanding several local phenomena implied by individual motion records

  8. Areas of Left Perisylvian Cortex Mediate Auditory-Verbal Short-Term Memory

    Science.gov (United States)

    Koenigs, Michael; Acheson, Daniel J.; Barbey, Aron K.; Solomon, Jeffrey; Postle, Bradley R.; Grafman, Jordan

    2011-01-01

    A contentious issue in memory research is whether verbal short-term memory (STM) depends on a neural system specifically dedicated to the temporary maintenance of information, or instead relies on the same brain areas subserving the comprehension and production of language. In this study, we examined a large sample of adults with acquired brain…

  9. Role of the Ventral Tegmental Area in Methamphetamine Extinction: AMPA Receptor-Mediated Neuroplasticity

    Science.gov (United States)

    Chen Han-Ting; Chen, Jin-Chung

    2015-01-01

    The molecular mechanisms underlying drug extinction remain largely unknown, although a role for medial prefrontal cortex (mPFC) glutamate neurons has been suggested. Considering that the mPFC sends glutamate efferents to the ventral tegmental area (VTA), we tested whether the VTA is involved in methamphetamine (METH) extinction via conditioned…

  10. A proof for insignificant effect of Brownian motion-induced micro-convection on thermal conductivity of nanofluids by utilizing molecular dynamics simulations

    Science.gov (United States)

    Babaei, Hasan; Keblinski, Pawel; Khodadadi, J. M.

    2013-02-01

    It has been recently demonstrated through experiments that the observed high enhancements in thermal conductivity of nanofluids are due to aggregation of nanoparticles rather than the previously stated mechanism of the Brownian motion-induced micro-convection. In this paper, we use equilibrium molecular dynamics simulations to investigate the role of micro-convection on the thermal conductivity of well-dispersed nanofluids. We show that while the individual terms in the heat current autocorrelation function associated with nanoparticle diffusion achieve significant values, these terms essentially cancel each other if correctly defined average enthalpy expressions are subtracted. Otherwise, erroneous thermal conductivity enhancements will be predicted, which are attributed to Brownian motion-induced micro-convection. Consequently, micro-convection does not contribute noticeably to the thermal conductivity and the predicted thermal conductivity enhancements are consistent with the effective medium theory.

  11. Ventral tegmental area cholinergic mechanisms mediate behavioral responses in the forced swim test.

    Science.gov (United States)

    Addy, N A; Nunes, E J; Wickham, R J

    2015-07-15

    Recent studies revealed a causal link between ventral tegmental area (VTA) phasic dopamine (DA) activity and pro-depressive and antidepressant-like behavioral responses in rodent models of depression. Cholinergic activity in the VTA has been demonstrated to regulate phasic DA activity, but the role of VTA cholinergic mechanisms in depression-related behavior is unclear. The goal of this study was to determine whether pharmacological manipulation of VTA cholinergic activity altered behavioral responding in the forced swim test (FST) in rats. Here, male Sprague-Dawley rats received systemic or VTA-specific administration of the acetylcholinesterase inhibitor, physostigmine (systemic; 0.06 or 0.125mg/kg, intra-cranial; 1 or 2μg/side), the muscarinic acetylcholine receptor (AChR) antagonist scopolamine (2.4 or 24μg/side), or the nicotinic AChR antagonist mecamylamine (3 or 30μg/side), prior to the FST test session. In control experiments, locomotor activity was also examined following systemic and intra-cranial administration of cholinergic drugs. Physostigmine administration, either systemically or directly into the VTA, significantly increased immobility time in FST, whereas physostigmine infusion into a dorsal control site did not alter immobility time. In contrast, VTA infusion of either scopolamine or mecamylamine decreased immobility time, consistent with an antidepressant-like effect. Finally, the VTA physostigmine-induced increase in immobility was blocked by co-administration with scopolamine, but unaltered by co-administration with mecamylamine. These data show that enhancing VTA cholinergic tone and blocking VTA AChRs has opposing effects in FST. Together, the findings provide evidence for a role of VTA cholinergic mechanisms in behavioral responses in FST.

  12. Mediating effect of mental disorders in the pathway between life events and mental health services use: results from the Baltimore Epidemiologic Catchment Area study.

    Science.gov (United States)

    Maulik, Pallab K; Eaton, William W; Bradshaw, Catherine P

    2010-03-01

    This study assessed the role of some common mental health conditions as mediators in the pathway between suffering life events and using mental health services. The participants were from the Baltimore Epidemiologic Catchment Area cohort, interviewed in 1993 to 1996 and 2004 to 2005. Longitudinal data analysis was used to identify models with significant mediation. Only alcohol abuse/dependence disorder was a significant mediator in the pathway between suffering a life-threatening illness and using mental health services in a general medical setup. Female gender, being more than 65 years old, prior use of services and availability of health insurance were some of the factors that significantly predicted service use in that model. Some of other factors like social networks and social support, attitudes towards services, and stigma, may play a role in determining service use. Future research should investigate the role of such factors as mediators for mental health service use. PMID:20215995

  13. Normalization of flow-mediated dilation to shear stress area under the curve eliminates the impact of variable hyperemic stimulus

    Directory of Open Access Journals (Sweden)

    Mickleborough Timothy D

    2008-09-01

    Full Text Available Abstract Background Normalization of brachial artery flow-mediated dilation (FMD to individual shear stress area under the curve (peak FMD:SSAUC ratio has recently been proposed as an approach to control for the large inter-subject variability in reactive hyperemia-induced shear stress; however, the adoption of this approach among researchers has been slow. The present study was designed to further examine the efficacy of FMD normalization to shear stress in reducing measurement variability. Methods Five different magnitudes of reactive hyperemia-induced shear stress were applied to 20 healthy, physically active young adults (25.3 ± 0. 6 yrs; 10 men, 10 women by manipulating forearm cuff occlusion duration: 1, 2, 3, 4, and 5 min, in a randomized order. A venous blood draw was performed for determination of baseline whole blood viscosity and hematocrit. The magnitude of occlusion-induced forearm ischemia was quantified by dual-wavelength near-infrared spectrometry (NIRS. Brachial artery diameters and velocities were obtained via high-resolution ultrasound. The SSAUC was individually calculated for the duration of time-to-peak dilation. Results One-way repeated measures ANOVA demonstrated distinct magnitudes of occlusion-induced ischemia (volume and peak, hyperemic shear stress, and peak FMD responses (all p AUC (p = 0.785. Conclusion Our data confirm that normalization of FMD to SSAUC eliminates the influences of variable shear stress and solidifies the utility of FMD:SSAUC ratio as an index of endothelial function.

  14. Joint correction of Nyquist artifact and minuscule motion-induced aliasing artifact in interleaved diffusion weighted EPI data using a composite two-dimensional phase correction procedure.

    Science.gov (United States)

    Chang, Hing-Chiu; Chen, Nan-Kuei

    2016-09-01

    Diffusion-weighted imaging (DWI) obtained with interleaved echo-planar imaging (EPI) pulse sequence has great potential of characterizing brain tissue properties at high spatial-resolution. However, interleaved EPI based DWI data may be corrupted by various types of aliasing artifacts. First, inconsistencies in k-space data obtained with opposite readout gradient polarities result in Nyquist artifact, which is usually reduced with 1D phase correction in post-processing. When there exist eddy current cross terms (e.g., in oblique-plane EPI), 2D phase correction is needed to effectively reduce Nyquist artifact. Second, minuscule motion induced phase inconsistencies in interleaved DWI scans result in image-domain aliasing artifact, which can be removed with reconstruction procedures that take shot-to-shot phase variations into consideration. In existing interleaved DWI reconstruction procedures, Nyquist artifact and minuscule motion-induced aliasing artifact are typically removed subsequently in two stages. Although the two-stage phase correction generally performs well for non-oblique plane EPI data obtained from well-calibrated system, the residual artifacts may still be pronounced in oblique-plane EPI data or when there exist eddy current cross terms. To address this challenge, here we report a new composite 2D phase correction procedure, which effective removes Nyquist artifact and minuscule motion induced aliasing artifact jointly in a single step. Our experimental results demonstrate that the new 2D phase correction method can much more effectively reduce artifacts in interleaved EPI based DWI data as compared with the existing two-stage artifact correction procedures. The new method robustly enables high-resolution DWI, and should prove highly valuable for clinical uses and research studies of DWI.

  15. The effect of high speed vessel operations on ship's crew and embarked personnel aboard HSV-2 SWIFT in the areas of motion sickness and motion induced task interruptions

    OpenAIRE

    Diaz, Alvaro

    2005-01-01

    The Navy's use of high speed vessels such as HSV-2 SWIFT has raised questions of the effects of high speed motion on the ability of personnel to perform assigned duties. Performance degradation may occur during periods of excessive ship motion because of extreme motion sickness or periods of frequent task interruptions. With the use of high speed vessels expected to increase in the near future with the Littoral Combat Ship program, the issue of high speed motion effects on personnel becom...

  16. Organochlorine pesticides (OCPs) in the Indus River catchment area, Pakistan: Status, soil-air exchange and black carbon mediated distribution.

    Science.gov (United States)

    Bajwa, Anam; Ali, Usman; Mahmood, Adeel; Chaudhry, Muhammad Jamshed Iqbal; Syed, Jabir Hussain; Li, Jun; Zhang, Gan; Jones, Kevin C; Malik, Riffat Naseem

    2016-06-01

    Organochlorine pesticides (OCPs) were investigated in passive air and soil samples from the catchment area of the Indus River, Pakistan. ∑15OCPs ranged between 0.68 and 13.47 ng g(-1) in soil and 375.1-1975 pg m-(3) in air. HCHs and DDTs were more prevalent in soil and air compartments. Composition profile indicated that β-HCH and p,p'-DDE were the dominant of all metabolites among HCHs and DDTs respectively. Moreover, fBC and fTOC were assessed and evaluated their potential role in the distribution status of OCPs. The fTOC and fBC ranged between 0.77 and 2.43 and 0.04-0.30% respectively in soil. Regression analysis showed the strong influence of fBC than fTOC on the distribution of OCPs in the Indus River catchment area soil. Equilibrium status was observed for β-HCH, δ-HCH, p,p'-DDD, o,p'-DDT, TC, HCB and Heptachlor with ff ranged between 0.3 and 0.59 while assessing the soil-air exchange of OCPs. PMID:26978705

  17. Subtle reproductive impairment through nitric oxide-mediated mechanisms in sea urchins from an area affected by harmful algal blooms

    Science.gov (United States)

    Migliaccio, Oriana; Castellano, Immacolata; di Cioccio, Davide; Tedeschi, Gabriella; Negri, Armando; Cirino, Paola; Romano, Giovanna; Zingone, Adriana; Palumbo, Anna

    2016-05-01

    The health of the sea urchin Paracentrotus lividus, a key species in the Mediterranean Sea, is menaced by several pressures in coastal environments. Here, we aimed at assessing the reproductive ability of apparently healthy P. lividus population in a marine protected area affected by toxic blooms of Ostreospsis cf. ovata. Wide-ranging analyses were performed in animals collected prior to and during the bloom, as well as at several times thereafter, during the reproductive season. Adults showed a low fertilization rate, along with high nitric oxide (NO) levels in the gonads and the nitration of the major yolk protein toposome, which is an important player in sea urchin development. Serious developmental anomalies were observed in the progeny, which persist several months after the bloom. NO levels were high in the different developmental stages, which also showed variations in the transcription of several genes that were found to be directly or indirectly modulated by NO. These results highlight subtle but important reproductive flaws transmitted from the female gonads to the offspring with the NO involvement. Despite a recovery along time after the bloom, insidious damages can be envisaged in the local sea urchin population, with possible reverberation on the whole benthic system.

  18. An increase in the cerebral infarction area during fatigue is mediated by il-6 through an induction of fibrinogen synthesis

    Directory of Open Access Journals (Sweden)

    Hong Lei

    2014-06-01

    Full Text Available OBJECTIVES:Our study aimed to investigate the impact of fatigue on the severity of stroke and to explore the underlying mechanisms.METHODS:Fatigued male rats underwent middle cerebral artery occlusion and the infarcted brain area was determined. Then, coagulation parameters were assessed in the fatigued group and a control group. In addition, the level of fibrinogen was determined in rats deprived of sleep for various numbers of days. To study whether interleukin-6 was involved in fibrinogen synthesis during fatigue, we also measured levels of interleukin-6 in rats deprived of sleep for various numbers of days. Furthermore, brain injury by middle cerebral artery occlusion was measured in wild-type mice, interleukin-6-/- mice and wild-type mice treated with bezafibrate.RESULTS:More severe cerebral infarction was observed in the fatigued rats, resulting in an infarct ratio of 23.4%. The infarct ratio was significantly increased in the fatigued rats compared with that in the control group (8%, p<0.05. The level of fibrinogen was increased significantly in the fatigued rats compared with that in the control group. In addition, a marked reduction in fibrinogen level was observed in the fatigued interleukin-6-/- mice compared to their wild-type counterparts, whereas no difference was observed between fatigued wild-type mice and interleukin-6-/- rats treated with recombinant human interleukin-6. The reduction in brain injury due to middle cerebral artery occlusion during fatigue was observed in interleukin-6-/- mice and wild-type mice treated with bezafibrate.CONCLUSION:Fatigue could increase stroke severity and was associated with the interleukin-6-induced expression of fibrinogen.

  19. Increased desensitization of dopamine D₂ receptor-mediated response in the ventral tegmental area in the absence of adenosine A(2A) receptors.

    Science.gov (United States)

    Al-Hasani, R; Foster, J D; Metaxas, A; Ledent, C; Hourani, S M O; Kitchen, I; Chen, Y

    2011-09-01

    G-protein coupled receptors interact to provide additional regulatory mechanisms for neurotransmitter signaling. Adenosine A(2A) receptors are expressed at a high density in striatal neurons, where they closely interact with dopamine D₂ receptors and modulate effects of dopamine and responses to psychostimulants. A(2A) receptors are expressed at much lower densities in other forebrain neurons but play a more prominent yet opposing role to striatal receptors in response to psychostimulants in mice. It is, therefore, possible that A(2A) receptors expressed at low levels elsewhere in the brain may also regulate neurotransmitter systems and modulate neuronal functions. Dopamine D₂ receptors play an important role in autoinhibition of neuronal firing in dopamine neurons of the ventral tegmental area (VTA) and dopamine release in other brain areas. Here, we examined the effect of A(2A) receptor deletion on D₂ receptor-mediated inhibition of neuronal firing in dopamine neurons in the VTA. Spontaneous activity of dopamine neurons was recorded in midbrain slices, and concentration-dependent effects of the dopamine D₂ receptor agonist, quinpirole, was compared between wild-type and A(2A) knockout mice. The potency of quinpirole applied in single concentrations and the expression of D₂ receptors were not altered in the VTA of the knockout mice. However, quinpirole applied in stepwise escalating concentrations caused significantly reduced maximal inhibition in A(2A) knockout mice, indicating an enhanced agonist-induced desensitization of D₂ receptors in the absence of A(2A) receptors. The A(2A) receptor agonist, CGS21680, did not exert any effect on dopamine neuron firing or response to quinpirole, revealing a novel non-pharmacological interaction between adenosine A(2A) receptors and dopaminergic neurotransmission in midbrain dopamine neurons. Altered D₂ receptor desensitization may result in changes in dopamine neuron firing rate and pattern and dopamine

  20. AhR-mediated potency of sediments and soils in estuarine and coastal areas of the Yellow Sea region: A comparison between Korea and China

    International Nuclear Information System (INIS)

    Extracts of sediments (n = 45) and soils (n = 37) collected from the coast of the Yellow Sea, in Korea and China, were screened for their ability to induce dioxin-like gene expression in vitro using the H4IIE-luc, transactivation bioassay. Significant dioxin-like potency was observed except for a few soils from Korea. Concentrations of TCDD-EQ (2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents) in sediments were comparable between Korea and China, but concentrations of TCDD-EQ in soil were 2-fold greater from Korea. Mass balance analysis indicated that concentrations of TCDD-EQ were to some degree chemical- and/or matrix-dependent, but were much more site-specific. For example, the proportion of the TCDD-EQ that could be identified varied among locations, which suggests different sources. Unidentified AhR-active compounds represented a greater proportion of the TCDD-EQ in samples from Korea, which suggests that sources in Korea were more complex than those in China. Potential sources of TCDD-EQ were investigated by considering land-uses and local activities. - Highlights: ► AhR potencies of 45 sediment and 37 soil samples of the Yellow Sea region were determined. ► Some samples contained dioxin-like compounds from regional human activities. ► PAHs were dominant and widespread contributors in both sediments and soils. ► Unknown AhR agonists were widely distributed in sediments and soils. ► Dominant AhR agonists in sediments and soils were found to be site-specific. - AhR-mediated potencies of sediments and soils in estuarine and coastal areas of the West Sea of Korea and north Bohai Sea of China was due known and unknown AhR agonists.

  1. Investigating the spatial variability in incidence of coronary heart disease in the Gazel cohort: the impact of area socioeconomic position and mediating role of risk factors.

    OpenAIRE

    Silhol, Romain; Zins, Marie; Chauvin, Pierre; Chaix, Basile

    2011-01-01

    STUDY OBJECTIVE: The aim of the study was to improve understanding of the relationships between contextual socioeconomic characteristics and coronary heart disease (CHD) incidence in France. Several authors have suggested that CHD risk factors (diabetes, hypertension, cholesterol, overweight, tobacco consumption) may partly mediate associations between socioeconomic environmental variables and CHD. Studies have assessed the overall mediating role of CHD risk factors, but have never investigat...

  2. Mediation Analysis

    OpenAIRE

    David P. MacKinnon; Fairchild, Amanda J.; Fritz, Matthew S.

    2007-01-01

    Mediating variables are prominent in psychological theory and research. A mediating variable transmits the effect of an independent variable on a dependent variable. Differences between mediating variables and confounders, moderators, and covariates are outlined. Statistical methods to assess mediation and modern comprehensive approaches are described. Future directions for mediation analysis are discussed.

  3. Plant-plant interactions mediate the plastic and genotypic response of Plantago asiatica to CO2 : an experiment with plant populations from naturally high CO2 areas

    NARCIS (Netherlands)

    van Loon, Marloes P; Rietkerk, Max; Dekker, Stefan C; Hikosaka, Kouki; Ueda, Miki U; Anten, Niels P R

    2016-01-01

    Background and Aims The rising atmospheric CO2 concentration ([CO2]) is a ubiquitous selective force that may strongly impact species distribution and vegetation functioning. Plant–plant interactions could mediate the trajectory of vegetation responses to elevated [CO2], because some plants may bene

  4. Mediation in Romanian Legislation

    Directory of Open Access Journals (Sweden)

    Gianina Anemona Radu

    2012-05-01

    Full Text Available The complexity of the current social relations generates the necessity of developing and applyingnew methods of settling conflicts. Mediation can serve as an effective tool in resolving various conflictsincluding the criminal matters. This article gives a panoramic view on the application of the concept ofmediation and highlights the main features of mediation in criminal cases as they are reported to the nationallegislation and the legislation of Romania. Therefore the advantages of mediation and the opportunity toapply the latter in order to slave the conflicts caused by the commission of criminal offences are still beingdiscussed. The Romanian legislation and the Community rules establish the scope of expressly exemptedareas, the sides of freedom being the main principle, the mandatory dispositions being the exception. Fromthe contents of the Law 192/2006 result that mediation is exercisable in all areas with the condition that therights which make the subject of mediation could be used by the sides of the mediation. The mediation theoryanalyses the extrajudicial mediation and judicial mediation settlement.

  5. ENVIRONMENTAL CONFLICT MEDIATION

    Directory of Open Access Journals (Sweden)

    GABRIELA G. MIHUT

    2011-04-01

    Full Text Available At a time of global economic crisis followed by resource crisis, a period in which the world seeks alternative resources through eco-investment, environmental conflicts are inevitable. Romania is among the few countries that do not pay enough attention to environmental conflicts and to the advantages to of solving them through mediation procedure. The present paper deals with areas in which conflicts can be applied in environmental mediation and its benefits.

  6. ENVIRONMENTAL CONFLICT MEDIATION

    OpenAIRE

    GABRIELA G. MIHUT

    2011-01-01

    At a time of global economic crisis followed by resource crisis, a period in which the world seeks alternative resources through eco-investment, environmental conflicts are inevitable. Romania is among the few countries that do not pay enough attention to environmental conflicts and to the advantages to of solving them through mediation procedure. The present paper deals with areas in which conflicts can be applied in environmental mediation and its benefits.

  7. Mediation and Counseling Services: A Viable Partnership

    Science.gov (United States)

    Hodges, Shannon

    2009-01-01

    Mediation has become common in many areas of society, including marital dissolution, community disputes, governmental agencies, and business and industry. Though higher education has been slower than society to adopt mediation services, campus mediation is becoming increasingly more common. This article explains why mediation is a viable…

  8. Complex Mediation

    DEFF Research Database (Denmark)

    Bødker, Susanne; Andersen, Peter Bøgh

    2005-01-01

    This article has its starting point in a large number of empirical findings regarding computer-mediated work. These empirical findings have challenged our understanding of the role of mediation in such work; on the one hand as an aspect of communication and cooperation at work and on the other ha...

  9. Specialized Mediation.

    Science.gov (United States)

    Hammond, Carol; And Others

    1992-01-01

    Six articles discuss librarians as mediators in special circumstances. Highlights include the reference librarian and the information paraprofessional; effective reference mediation for nontraditional public library users, including mentally impaired patrons and illiterate adults; the academic librarian's role in the education process; and…

  10. Aversive behavior induced by optogenetic inactivation of ventral tegmental area dopamine neurons is mediated by dopamine D2 receptors in the nucleus accumbens.

    Science.gov (United States)

    Danjo, Teruko; Yoshimi, Kenji; Funabiki, Kazuo; Yawata, Satoshi; Nakanishi, Shigetada

    2014-04-29

    Dopamine (DA) transmission from the ventral tegmental area (VTA) is critical for controlling both rewarding and aversive behaviors. The transient silencing of DA neurons is one of the responses to aversive stimuli, but its consequences and neural mechanisms regarding aversive responses and learning have largely remained elusive. Here, we report that optogenetic inactivation of VTA DA neurons promptly down-regulated DA levels and induced up-regulation of the neural activity in the nucleus accumbens (NAc) as evaluated by Fos expression. This optogenetic suppression of DA neuron firing immediately evoked aversive responses to the previously preferred dark room and led to aversive learning toward the optogenetically conditioned place. Importantly, this place aversion was abolished by knockdown of dopamine D2 receptors but not by that of D1 receptors in the NAc. Silencing of DA neurons in the VTA was thus indispensable for inducing aversive responses and learning through dopamine D2 receptors in the NAc.

  11. Examining Rotational Ground Motion Induced by Tornados

    Science.gov (United States)

    Kessler, Elijah; Dunn, Robert

    2016-03-01

    Ring lasers are well known for their ability to detect rotation and to serve as replacements for mechanical gyroscopes. The sensitivity of large ring lasers to various forms of ground motion is less familiar. Since ring lasers preferentially measure rotational ground motion and a standard seismograph is designed to measure translational and vertical ground motion, each device responds to different aspects of ground movement. Therefore, the two instruments will be used to explore responses to microseisms, earthquake generated shear waves, and in particular tornado generated ground movement. On April 27, 2014 an EF4 tornado devastated Vilonia, AR a small town ~ 21 km from the Hendrix College ring laser. The proximity of the tornado's path to the ring laser interferometer and to a seismograph located in Vilonia provided the opportunity to examine the response of these instruments to tornadic generated ground motion. Our measurements suggest tornadic weather systems can produce both rotational and lateral ground motion. This contention is supported by an after the fact damage survey which found that the tornado flattened a forest in which trees were uprooted and laid down in a pair of converging arcs with the centerline pointed in the direction of the tornado's path.

  12. Mediating Business

    DEFF Research Database (Denmark)

    "Mediating Business" is a study of the expansion of business journalism. Building on evidence from Denmark, Finland, Norway and Sweden, "Mediating Business" is a comparative and multidisciplinary study of one of the major transformations of the mass media and the realm of business - nationally...... and globally. The book explores the history of key innovations and innovators in the business press. It analyzes changes in the discourse of business journalism associated with the growth in business news and the development of new ways of framing business issues and events. Finally, it examines...... the organizational implications of the increased media visibility of business and, in particular, the development of corporate governance and media relations....

  13. Mediatized play

    DEFF Research Database (Denmark)

    Johansen, Stine Liv

    Children’s play must nowadays be understood as a mediatized field in society and culture. Media – understood in a very broad sense - holds severe explanatory power in describing and understanding the practice of play, since play happens both with, through and inspired by media of different sorts...

  14. Mediatized Humanitarianism

    DEFF Research Database (Denmark)

    Vestergaard, Anne

    2014-01-01

    The article investigates the implications of mediatization for the legitimation strategies of humanitarian organizations. Based on a (full population) corpus of ~400 pages of brochure material from 1970 to 2007, the micro-textual processes involved in humanitarian organizations' efforts to legiti......The article investigates the implications of mediatization for the legitimation strategies of humanitarian organizations. Based on a (full population) corpus of ~400 pages of brochure material from 1970 to 2007, the micro-textual processes involved in humanitarian organizations' efforts...... to legitimate themselves and their moral claim were examined. A time trend analysis of the prioritization of actors in the material indicates that marked shifts in legitimation loci have taken place during the past 40 years. A discourse analysis unfolds the three dominant discourses behind these shifts, namely...

  15. The mediatization of ethical consumption

    DEFF Research Database (Denmark)

    Eskjær, Mikkel Fugl

    2013-01-01

    Over the years, mediatization studies have investigated the influence of media in numerous sections of contemporary society. One area that has received limited attention is the mediatization of consumption, particularly issues concerning ethical consumption. This article presents a study of how...... mediatization is transforming modern consumption and contributing to the mainstreaming of ethical consumption. Based on a study of a Danish online eco-store, the article argues that modern ethical consumption increasingly depends on new media practices to present sustainable consumption as practical and...

  16. Mediation of information and educational mediation: conceptual discussions

    Directory of Open Access Journals (Sweden)

    Helena Célia de Souza Sacerdote

    2016-04-01

    Full Text Available Introduction: This is systematization of theoretical and methodological contributions related to the concepts of mediation information and pedagogical mediation in the literature. Objective: To understand possible intersection of information science and Online Education with regard to these concepts to check that both can be considered as analogous in its essence and practice. Methodology: Literature review based on literature by consulting the scientific productions selected in search of SciELO.ORG databases and EBSCO Host, the portal of CAPES / MEC and Google Scholar. Results: The most cited concepts in information science and education were de Almeida Junior (2009 and Masetto (2013, respectively. Conclusion: It is observed that the concept of mediation can move interchangeably between both areas. This is because the evidence found in the productions of the last five years indicate that the concept of information of mediation seems to have found its bases in education (educational psychology.

  17. PRACTICAL ASPECTS OF MEDIATION

    OpenAIRE

    IULIA FLOCA

    2011-01-01

    Today the Romanian state gives some advantages to those who use mediation. If the Romanian state would take further steps, mediation would work as in the countries with old tradition. The article refers to success and failure got in the two years of practice. The mediation can be seen in two aspects: The first aspect regarding the mediation itself can lead to a mediation agreement. The mediation agreement gives both winnings to the conflict parts and professional satisfactions to the mediator...

  18. Micro dynamics in mediation

    OpenAIRE

    Boserup, Hans

    2014-01-01

    The author has identified a number of styles in mediation, which lead to different processes and different outcomes. Through discourse and conversation analysis he examines the micro dynamics in three of these, the postmodern styles: systemic, transformative and narrative mediation. The differences between the three mediation ideologies and practice is illustrated through role play scripts enacted in each style. Mediator and providers of mediation and trainers in mediation are encouraged to a...

  19. Spring-mediated skull expansion: overall effects in sutural and parasutural areas. An experimental study in rabbits Expansão craniana com molas: efeitos globais nas áreas suturais e parassuturais. Estudo experimental em coelhos

    Directory of Open Access Journals (Sweden)

    Rodrigo de Faria Valle Dornelles

    2010-04-01

    Full Text Available PURPOSE: The use of springs in cranial expansion has proven to be effective in the treatment of craniosynostosis. Spring-mediated expansion has been studied both in the sagittal and in parasagittal regions, especially in scaphocephaly. A rabbit model was used in the present study to analyze the effects of springs on the cranial vault and sutures. METHODS: Thirteen 4-week-old New Zealand rabbits were divided into 4 groups: in group I, only amalgam markers were used as control; in group II, amalgam markers were used and sagittal suturectomy was performed; in group III, amalgam markers were used, a sagittal suturectomy was performed and an expansible spring was fitted in the interparietal region and in group IV, markers were used and linear parasagittal craniectomy was carried out with springs. Animals were sacrificed after 2, 4, 8 and 12 weeks. Radiological control and histological analysis were performed in the area of spring implantation. RESULTS: In the groups using springs distraction of the craniectomy borders was greater than in those that did not use springs. New bone formation was observed in all groups, and was faster in group II. Bone growth started from the borders and depth. Bone regeneration presented a similar histological pattern in the groups with spring in the sagittal and parasagittal region. CONCLUSION: The rabbit model proved to be adequate for the analysis proposed by the study. The use of springs in the groups with sagittal and parasagittal osteotomy led to a similar distraction of amalgam markers and both groups had similar ossification histological pattern.OBJETIVO: O uso de molas na expansão craniana tem provado ser efetivo no tratamento da craniossinostoses. A expansão com molas tem sido estudada nas regiões sagital e parassagital, especialmente nas escafocefalias. Um modelo com coelho foi usado no presente estudo para analizar os efeitos das molas sobre a calota craniana e suturas. MÉTODOS: Treze coelhos Nova Zel

  20. Water-Mediated Hydrophobic Interactions.

    Science.gov (United States)

    Ben-Amotz, Dor

    2016-05-27

    Hydrophobic interactions are driven by the combined influence of the direct attraction between oily solutes and an additional water-mediated interaction whose magnitude (and sign) depends sensitively on both solute size and attraction. The resulting delicate balance can lead to a slightly repulsive water-mediated interaction that drives oily molecules apart rather than pushing them together and thus opposes their direct (van der Waals) attraction for each other. As a consequence, competing solute size-dependent crossovers weaken hydrophobic interactions sufficiently that they are only expected to significantly exceed random thermal energy fluctuations for processes that bury more than ∼1 nm(2) of water-exposed area. PMID:27215821

  1. General Gaugino Mediation

    OpenAIRE

    Sudano, Matthew

    2010-01-01

    The spectrum of a class of gaugino mediation models with arbitrary hidden sector is considered. These models are defined by a diagonal breaking of the mediating gauge group, which places them outside the realm of General Gauge Mediation. While gauginos get masses as in ordinary gauge mediation, the scalar masses are screened.

  2. Conceptualising International Peace Mediation - Bring Back the Law

    OpenAIRE

    Higgins, Noelle; Daly, Brenda

    2011-01-01

    Mediation has been acknowledged and utilised for a number of decades as an effective method of alternative dispute resolution in a variety of areas of law, including family law, commercial law and medical law. A uniform, standardised framework exists within legal discourse which clearly identifies and categorises three main styles of mediation as facilitative, evaluative and transformative mediation. In the post-Cold War period, mediation has also emerged as an important resolution tool in ar...

  3. Shared mediated workspaces

    OpenAIRE

    Greef, Tjerk de; Gullström, Charlie; Handberg, Leif; Nefs, H.T.; Parnes, Peter

    2012-01-01

    Shared mediated spaces provide viable alternatives for meetings and interactions. The development of collaborative mediated workspaces and shared negotiation spaces will have a fundamental impact on all human practices. Previous design-led research, has identified spatial design concepts, such as mediated gaze, and spatial montage, which, if unaddressed, may be said to impose friction, and thus impact negatively on the experience of mediated presence. The current paper discusses a set of conc...

  4. Confidentiality of mediation communications

    OpenAIRE

    Koo, AKC

    2011-01-01

    Discusses the common law protection afforded to mediation negotiations by the without prejudice rule, legal professional privilege and the mediation agreement signed by all parties prior to the commencement of the mediation process. Examines the inclusion of admissions within the without prejudice rule, and the exceptions to the rule. Notes two pieces of legislation offering protection, namely the US Uniform Mediation Act 2001 and Directive 2008/52. Argues that the limited protection in the U...

  5. Bayesian Mediation Analysis

    OpenAIRE

    Yuan, Ying; MacKinnon, David P.

    2009-01-01

    This article proposes Bayesian analysis of mediation effects. Compared to conventional frequentist mediation analysis, the Bayesian approach has several advantages. First, it allows researchers to incorporate prior information into the mediation analysis, thus potentially improving the efficiency of estimates. Second, under the Bayesian mediation analysis, inference is straightforward and exact, which makes it appealing for studies with small samples. Third, the Bayesian approach is conceptua...

  6. Mediation as Signal

    OpenAIRE

    Holler, M.J.; Lindner, I.

    2004-01-01

    This paper analyzes mediation as a signal. Starting from a stylized case, a game theoretical model of one-sided incomplete information, taken from Cho and Kreps (1987), is applied to discuss strategic effects of mediation. It turns out that to reject mediation can be interpreted as a ”negative signal” while the interpretation of accepting or proposing mediation is ambiguous and does not necessarily change the prior beliefs of the uninformed party. This asymmetry suggests that, in equilibrium,...

  7. mediation: R Package for Causal Mediation Analysis

    Directory of Open Access Journals (Sweden)

    Dustin Tingley

    2014-09-01

    Full Text Available In this paper, we describe the R package mediation for conducting causal mediation analysis in applied empirical research. In many scientific disciplines, the goal of researchers is not only estimating causal effects of a treatment but also understanding the process in which the treatment causally affects the outcome. Causal mediation analysis is frequently used to assess potential causal mechanisms. The mediation package implements a comprehensive suite of statistical tools for conducting such an analysis. The package is organized into two distinct approaches. Using the model-based approach, researchers can estimate causal mediation effects and conduct sensitivity analysis under the standard research design. Furthermore, the design-based approach provides several analysis tools that are applicable under different experimental designs. This approach requires weaker assumptions than the model-based approach. We also implement a statistical method for dealing with multiple (causally dependent mediators, which are often encountered in practice. Finally, the package also offers a methodology for assessing causal mediation in the presence of treatment noncompliance, a common problem in randomized trials.

  8. Bayesian Mediation Analysis

    Science.gov (United States)

    Yuan, Ying; MacKinnon, David P.

    2009-01-01

    In this article, we propose Bayesian analysis of mediation effects. Compared with conventional frequentist mediation analysis, the Bayesian approach has several advantages. First, it allows researchers to incorporate prior information into the mediation analysis, thus potentially improving the efficiency of estimates. Second, under the Bayesian…

  9. Mediation as Signal

    NARCIS (Netherlands)

    Holler, M.J.; Lindner, I.

    2004-01-01

    This paper analyzes mediation as a signal. Starting from a stylized case, a game theoretical model of one-sided incomplete information, taken from Cho and Kreps (1987), is applied to discuss strategic effects of mediation. It turns out that to reject mediation can be interpreted as a ”negative signa

  10. Hybrid Gauge Mediation

    OpenAIRE

    McGarrie, Moritz

    2011-01-01

    Inspired by four dimensional (de)constructions, we use the framework of "General gauge mediation in five dimensions" to interpolate between gaugino and ordinary gauge mediation. In particular we emphasise that an intermediate hybrid regime of mediation may be obtained in these higher dimensional models as has been obtained in the quiver gauge models.

  11. Phenomenological Implications of Deflected Mirage Mediation: Comparison with Mirage Mediation

    OpenAIRE

    Altunkaynak, Baris; Everett, Lisa L.; Kim, Ian-Woo; Nelson, Brent D.; Rao, Yongyan

    2010-01-01

    We compare the collider phenomenology of mirage mediation and deflected mirage mediation, which are two recently proposed "mixed" supersymmetry breaking scenarios motivated from string compactifications. The scenarios differ in that deflected mirage mediation includes contributions from gauge mediation in addition to the contributions from gravity mediation and anomaly mediation also present in mirage mediation. The threshold effects from gauge mediation can drastically alter the low energy s...

  12. Does area V3A predict positions of moving objects?

    Directory of Open Access Journals (Sweden)

    Gerrit W Maus

    2010-11-01

    Full Text Available A gradually fading moving object is perceived to disappear at positions beyond its luminance detection threshold, whereas abrupt offsets are usually localised accurately. What role does retinotopic activity in visual cortex play in this motion-induced mislocalization of the endpoint of fading objects? Using functional magnetic resonance imaging (fMRI, we localised regions of interest (ROIs in retinotopic maps abutting the trajectory endpoint of a bar moving either towards or away from this position while gradually decreasing or increasing in luminance. Area V3A showed predictive activity, with stronger fMRI responses for motion towards versus away from the ROI. This effect was independent of the change in luminance. In Area V1 we found higher activity for high-contrast onsets and offsets near the ROI, but no significant differences between motion directions. We suggest that perceived final positions of moving objects are based on an interplay of predictive position representations in higher motion-sensitive retinotopic areas and offset transients in primary visual cortex.

  13. The Schizosaccharomyces pombe Mediator

    DEFF Research Database (Denmark)

    Venturi, Michela

    In the past several years great attention has been dedicated to the characterization of the Mediator complex in a different range of model organisms. Mediator is a conserved co-activator complex involved in transcriptional regulation and it conveys signals from regulatory transcription factors to...... the basal transcription machinery. Mediator was initially isolated from Saccharomyces cerevisiae based on its ability to render a RNA polymerase II in vitro transcription system responsive to activators. Additionally, structural studies have revealed striking structural similarities between S....... cerevisiae, Schizosaccharomyces pombe and mammalian Mediator. In our study, we have taken the S. pombe Mediator into consideration and characterized genetically and biochemically two subunits already know in S. cerevisiae, Med9 and Med11, but still not identified in the S. pombe Mediator. Genetic analysis...

  14. Mediation and Domestic Violence

    OpenAIRE

    Jacques Faget

    2005-01-01

    This paper analyzes the potential and limits of recourse to mediation for regulating domestic violence. On the basis of an empirical study of its implementation in France and of the existing academic literature, it shows the existence of two types of practices reflecting two conceptions of mediation and more generally, two conceptions of the articulation between social and penal regulation

  15. Teaching Mediated Public Relations.

    Science.gov (United States)

    Kent, Michael L.

    2001-01-01

    Discusses approaches to teaching a mediated public relations course, emphasizing the World Wide Web. Outlines five course objectives, assignments and activities, evaluation, texts, and lecture topics. Argues that students mastering these course objectives will understand ethical issues relating to media use, using mediated technology in public…

  16. Dynamic public service mediation

    NARCIS (Netherlands)

    Hofman, W.; Staalduinen, M. van

    2010-01-01

    This paper presents an approach to dynamic public service mediation. It is based on a conceptual model and the use of search and ranking algorithms. The conceptual model is based on Abstract State Machine theory. Requirements for dynamic service mediation were derived from a real-world case. The con

  17. Mediation and Domestic Violence

    Directory of Open Access Journals (Sweden)

    Jacques Faget

    2005-07-01

    Full Text Available This paper analyzes the potential and limits of recourse to mediation for regulating domestic violence. On the basis of an empirical study of its implementation in France and of the existing academic literature, it shows the existence of two types of practices reflecting two conceptions of mediation and more generally, two conceptions of the articulation between social and penal regulation

  18. What Is Mediation?

    Science.gov (United States)

    Consortium for Appropriate Dispute Resolution in Special Education (CADRE), Eugene, OR.

    This brief paper discusses the use of mediation as a method for resolving disagreements between schools or early intervention programs and parents of children with disabilities. It identifies benefits of mediation such as maintenance of an ongoing and positive relationship between the school and family, simple resolution of conflicts arising out…

  19. Music, radio and mediatization

    DEFF Research Database (Denmark)

    Michelsen, Morten; Krogh, Mads

    2016-01-01

    Mediatization has become a key concept for understanding the relations between media and other cultural and social fields. Contributing to the discussions related to the concept of mediatization, this article discusses how practices of radio and music(al life) influence each other. We follow Deacon......’s and Stanyer’s advice to supplement the concept of mediatization with ‘a series of additional concepts at lower levels of abstraction’ and suggest, in this respect, the notion of heterogeneous milieus of music– radio. Hereby, we turn away from the all-encompassing perspectives related to the concept...... of mediatization where media as such seem to be ascribed agency. Instead, we consider historical accounts of music–radio in order to address the complex non- linearity of concrete processes of mediatization as they take place in the multiple meetings between a decentred notion of radio and musical life....

  20. Motion Induced by Light: Photokinetic Effects in the Rayleigh Limit

    CERN Document Server

    Ruffner, David B; Grier, David G

    2015-01-01

    Structured beams of light can move small objects in surprising ways. Particularly striking examples include observations of polarization-dependent forces acting on optically isotropic objects and tractor beams that can pull objects opposite to the direction of the light's propagation. Here we develop a theoretical framework in which these effects vanish at the leading order of light scattering theory. Exotic optical forces emerge instead from interference between different orders of multipole scattering. These effects create a rich variety of ways to manipulate small objects with light, so-called photokinetic effects. Applying this formalism to the particular case of Bessel beams offers useful insights into the nature of tractor beams and the interplay between spin and orbital angular momentum in vector beams of light, including a manifestation of orbital-to-spin conversion.

  1. Elastic image registration via rigid object motion induced deformation

    Science.gov (United States)

    Zheng, Xiaofen; Udupa, Jayaram K.; Hirsch, Bruce E.

    2011-03-01

    In this paper, we estimate the deformations induced on soft tissues by the rigid independent movements of hard objects and create an admixture of rigid and elastic adaptive image registration transformations. By automatically segmenting and independently estimating the movement of rigid objects in 3D images, we can maintain rigidity in bones and hard tissues while appropriately deforming soft tissues. We tested our algorithms on 20 pairs of 3D MRI datasets pertaining to a kinematic study of the flexibility of the ankle complex of normal feet as well as ankles affected by abnormalities in foot architecture and ligament injuries. The results show that elastic image registration via rigid object-induced deformation outperforms purely rigid and purely nonrigid approaches.

  2. Locomotive and reptation motion induced by internal force and friction

    Science.gov (United States)

    Sakaguchi, Hidetsugu; Ishihara, Taisuke

    2011-06-01

    We propose a simple mechanical model of locomotion induced by internal force and friction. We first construct a system of two elements as an analog of the bipedal motion. The internal force does not induce a directional motion by itself because of the action-reaction law, but a directional motion becomes possible by the control of the frictional force. The efficiency of these model systems is studied using an analogy to the heat engine. As a modified version of the two-element model, we construct a model that exhibits a bipedal motion similar to kinesin’s motion of molecular motor. Next, we propose a linear chain model and a ladder model as an extension of the original two-element model. We find a transition from a straight to a snake-like motion in a ladder model by changing the strength of the internal force.

  3. Locomotive and reptation motion induced by internal force and friction

    OpenAIRE

    Sakaguchi, Hidetsugu; Ishihara, Taisuke

    2011-01-01

    We propose a simple mechanical model of locomotion induced by internal force and friction. We first construct a system of two elements as an analog of the bipedal motion. The internal force does not induce a directional motion by itself because of the action-reaction law, but a directional motion becomes possible by the control of the frictional force. The efficiency of these model systems is studied using an analogy to the heat engine. As a modified version of the two-elements model, we cons...

  4. Motion-induced synchronization in metapopulations of mobile agents

    CERN Document Server

    Gómez-Gardeñes, Jesús; Sinatra, Roberta; Latora, Vito

    2012-01-01

    We study the influence of motion on the emergence of synchronization in a metapopulation of random walkers moving on a heterogeneous network and subject to Kuramoto interactions at the network nodes. We discover a novel mechanism of transition to macroscopic dynamical order induced by the walkers' motion. Furthermore, we observe two different microscopic paths to synchronization: depending on the rules of the motion, either low-degree nodes or the hubs drive the whole system towards synchronization. We provide analytical arguments to understand these results.

  5. Synchronized Intermittent Motion Induced by the Interaction between Camphor Disks

    Science.gov (United States)

    Suematsu, Nobuhiko J.; Tateno, Kurina; Nakata, Satoshi; Nishimori, Hiraku

    2015-03-01

    A new mode of collective motion was discovered in a system of camphor disks floating on the water surface in a circular chamber. The mode was induced by tuning the number of the disks. A single or few disks are known to continuously move on the water surface. Conversely, when many disks are present, motion comes to a stop and the disks form ordered spatial patterns by repulsive interaction. Here we found the third mode that emerged at an intermediate disk number, in which inactive and active motion phases alternated non-periodically. This new mode exhibited synchronization as the disk number increased.

  6. Revitalization Areas

    Data.gov (United States)

    Department of Housing and Urban Development — Revitalization areas are HUD-designated neighborhoods in need of economic and community development and where there is already a strong commitment by the local...

  7. Mediatization Theory and Digital Media

    DEFF Research Database (Denmark)

    Finnemann, Niels Ole

    2011-01-01

    In the 20th century, the term "media logic" was introduced to denote the influence of independent mass media on political systems and other institutions. In recent years the idea has been reworked and labelled "mediatization" to widen the framework by including new media and new areas of applicat......In the 20th century, the term "media logic" was introduced to denote the influence of independent mass media on political systems and other institutions. In recent years the idea has been reworked and labelled "mediatization" to widen the framework by including new media and new areas...... of application.  In Section Two the paper discusses different conceptualizations. It is argued that even if they bring new insights, they cannot be unified into one concept, and that they also lack a consistent definition of digital media. Section three provides a definition of digital media in order to identify...... new trajectories made possible by these media, which have led into a new media matrix built around the internet and mobile devices. It will be argued that the new media matrix cannot be understood from a point of view defined by the framework of 20th century mass media because digital media open new...

  8. Gravity in gauge mediation

    International Nuclear Information System (INIS)

    We investigate O'Raifeartaigh-type models for F-term supersymmetry breaking in gauge mediation scenarios in the presence of gravity. It is pointed out that the vacuum structure of those models is such that in metastable vacua gravity mediation contribution to scalar masses is always suppressed to the level below 1 percent, almost sufficient for avoiding FCNC problem. Close to that limit, gravitino mass can be in the range 10-100 GeV, opening several interesting possibilities for gauge mediation models, including Giudice-Masiero mechanism for μ and Bμ generation. Gravity sector can include stabilized moduli.

  9. General resonance mediation

    Energy Technology Data Exchange (ETDEWEB)

    McGarrie, Moritz

    2012-07-15

    We extend the framework of general gauge mediation to cases where the mediating fields have a nontrivial spectral function, as might arise from strong dynamics. We demonstrate through examples that this setup describes a broad class of possible models of gauge mediated supersymmetry breaking. A main emphasis is to give general formulas for cross sections for {sigma}(visible {yields} hidden) in these resonance models. We will also give formulas for soft masses, A-terms and demonstrate the framework with a holographic setup.

  10. Technology-Use Mediation

    DEFF Research Database (Denmark)

    Bansler, Jørgen P.; Havn, Erling C.

    2004-01-01

    that deepens our understanding of how organizations appropriate new electronic communication media. The paper analyzes how a group of mediators in a large, multinational company adapted a new web-based CMC technology (a virtual workspace) to the local organizational context (and vice versa) by modifying......Implementation of new computer-mediated communication (CMC) systems in organizations is a complex socio-technical endeavour, involving the mutual adaptation of technology and organization over time. Drawing on the analytic concept of sensemaking, this paper provides a theoretical perspective...... features of the technology, providing ongoing support for users, and promoting appropriate conventions of use. We found that these mediators exerted considerable influence on how the technology was established and used in the organization. The mediators were not neutral facilitators of a well...

  11. Natural generalized mirage mediation

    CERN Document Server

    Baer, Howard; Serce, Hasan; Tata, Xerxes

    2016-01-01

    In the supersymmetric scenario known as mirage mediation (MM), the soft SUSY breaking terms receive comparable anomaly-mediation and moduli-mediation contributions leading to the phenomenon of mirage unification. The simplest MM SUSY breaking models which are consistent with the measured Higgs mass and sparticle mass constraints are strongly disfavoured by fine-tuning considerations. However, while MM makes robust predictions for gaugino masses, the scalar sector is quite sensitive to specific mechanisms for moduli stabilization and potential uplifting. We suggest here a broader setup of generalized mirage mediation (GMM), where heretofore discrete parameters are allowed as continuous to better parametrize these other schemes. We find that natural SUSY spectra consistent with both the measured value of m(h). as well as LHC lower bounds on superpartner masses are then possible. We explicitly show that models generated from natural GMM may be beyond the reach of even high-luminosity LHC searches. In such a case...

  12. Interactive Mediated Reality

    OpenAIRE

    Grasset, Raphaël; Boissieux, Laurence; Gascuel, Jean-Dominique; Schmalstieg, Dieter

    2005-01-01

    International audience Mediated reality describes the concept of filtering our vision of reality, typically using a head-mounted video mixing display. We can redefine this idea in a more constructive context, applying dynamic changes to the appearance and geometry of objects in a real scene using computer graphics. In this paper, we propose new tools for interactively mediated reality. After describing a new generic framework for achieving this goal, we present a prototype system for paint...

  13. Inflammatory mediators in osteoarthritis

    OpenAIRE

    M Beekhuizen

    2014-01-01

    Osteoarthritis (OA) is a degenerative joint disorder involving cartilage destruction and joint inflammation. Despite extensive research, still much is unknown on the pathogenesis and aetiology of OA. Inflammation and inflammatory mediators (both local and systemic) are key in the pathogenesis of OA. For rheumatoid arthritis, multiple therapies are based on targeting the mediators that are associated with inflammation and joint destruction. Motivated by these findings we set off to identify wh...

  14. Chronic alloantibody mediated rejection

    OpenAIRE

    Smith, R. Neal; Colvin, Robert B.

    2011-01-01

    Alloantibodies clearly cause acute antibody mediated rejection, and all available evidence supports their pathogenic etiology in the development of chronic alloantibody mediated rejection (CAMR). But the slow evolution of this disease, the on-going immunosuppression, the variations in titer of alloantibodies, and variation in antigenic targets all complicate identifying which dynamic factors are most important clinically and pathologically. This review highlights the pathological factors rela...

  15. 清代新疆地区纠纷调解机制与当代国家法的差异与融合--以《清代新疆档案选辑》为考察视角%The Differences and Fusion between Dispute Mediation System in Xinjiang Area, Qing Dynasty---Taking the Xinjiang Files Selection of Qing Dynasty as the Perspectives

    Institute of Scientific and Technical Information of China (English)

    范文博

    2014-01-01

    The Qing Dynasty is a period of which ancient mediation system improved more perfectly. This thesis intends to take the Xinjiang files selection of Qing Dynasty as the perspectives, analyzes the differences and fusion between dispute mediation system in Xinjiang area, Qing Dynasty, meanwhile, discusses its enlightenment on contemporary national law.%清代是古代调解制度发展较为完善的时期。以《清代新疆档案选辑》为考察视角,在分析清代新疆地区纠纷解决机制与当代国家法的差异和融合的同时,探讨其对当代国家法的启示作用。

  16. Area monitoring

    International Nuclear Information System (INIS)

    The exposure of individuals to ionizing radiation is normally subject to legal controls which specify limits, and restriction, of doses that both occupational workers and members of the public are exposed to. The dose limits recommended by the International Commission on Radiological Protection (ICRP), and adopted by many countries are specified in terms of body dose equivalents, sometimes referred to as limiting quantities. However these quantities are not measurable since they are defined as average doses in organs and tissues of the human body. Thus for the same physical radiation field the dose delivered to an individual will not have a fixed value but will depend upon each individual's sex, age and physical construction as well as upon their orientation in the field. Ionizing radiation, also, cannot be detected by a person's physical senses of sight, smell, hearing and touch. Thus to control the levels of radiation to which individuals are exposed, special operational quantities are used and quantitative measurements have to be made using personal dosemeters or area monitoring equipment. This report describes the operational quantities that are being increasingly used worldwide for area monitoring. It provides information on the international standards that are available on the performance requirements for monitoring equipment designed to measure these operational quantities. It also reviews the recent international standards that have been published on the calibration and type testing of area monitors and gives an example of legislative requirements on area monitoring equipment. (author)

  17. Effective Area

    Directory of Open Access Journals (Sweden)

    Ehud Keinan

    2015-07-01

    Full Text Available This article defines a new term, Effective Area, K, of a given territory as a function of four independent parameters: its nominal acreage, A, the intellectual competence of its inhabitants, B, their social competence, C, and their global influence, D, using a simple formalism: K = A x B x C x D. This analysis demonstrates that in our current world any consideration of the physical area of a given territory is meaningless if the quality of its population is ignored. K is a much more useful parameter than A, certainly for political and economical considerations, explaining why claims for territorial expansion are placed low on the national ladder of priorities in the developed countries. In many respects, large geographical areas may become a burden rather than an advantage. Thus, the importance of armed conflicts over geographical territories, which have taken a dominant part of the entire human history, is fading away. Furthermore, although the global acreage is constant, the total effective area of planet Earth keeps growing, providing sufficient room for the growing human population.

  18. From Real Needs to Judicial Response:Research on the Mediation Judge Mode in Less Developed Rural Areas%由“现实需求”到“司法回应”--欠发达农村地区调解法官模式研究

    Institute of Scientific and Technical Information of China (English)

    田源; 李燕

    2014-01-01

    随着我国经济社会的飞速发展,农村地区的各类矛盾纠纷持续递增,影响了地方经济社会的和谐稳定。作为人民法院在农村地区的派驻机构,人民法庭承担着化解矛盾纠纷的重任。组建起一支与农村地区社会特点相适应的法官队伍,不仅是农村民众的共同现实需求,更是人民法院理应做出的司法回应。选取了S省D县人民法院作为分析样本,就欠发达农村地区调解法官模式的建构路径加以探究。%With the rapid economic and social development of our country , all kinds of contradictions and disputes in rural areas are growing ,affecting social stability .The people’s tribunal , as an agency of the People ’ s Court , undertakes the task of resolving conflicts and disputes . Establishing a group of judges adapt to the rural society is not only the common realistic demand of the rural people ,but also the judicial response the People’s Court should make .This paper selects the People’s Court of County D ,Province S as the analysis sample and explores the construction mode of mediation judges in less developed rural areas .

  19. [Immune-mediated neuropathies].

    Science.gov (United States)

    Stoll, G; Reiners, K

    2016-08-01

    The Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP) are the most common immune-mediated polyneuropathies, which can show variable clinical and electrophysiological manifestations. Rarer immune-mediated neuropathies encompass paraproteinemic neuropathies (PPN), multifocal motor neuropathy (MMN) and vasculitic neuropathies. The diagnosis usually relies on the history of symptom evolution, distribution of nerve dysfunction and particularly on characteristic features in nerve conduction studies, aided by cerebrospinal fluid (CSF) examination and nerve biopsy findings. The therapeutic toolbox encompasses corticosteroids, immunoglobulins and plasmapheresis often accompanied by long-term immunosuppression. It is important to note that immune-mediated neuropathies selectively respond to treatment and contraindications need to be considered. Despite treatment a considerable number of patients suffer from permanent neurological deficits. PMID:27474733

  20. Exploring general gauge mediation

    International Nuclear Information System (INIS)

    We explore various aspects of General Gauge Mediation (GGM). We present a reformulation of the correlation functions used in GGM, and further elucidate their IR and UV properties. Additionally we clarify the issue of UV sensitivity in the calculation of the soft masses in the MSSM, highlighting the role of the supertrace over the messenger spectrum. Finally, we present weakly coupled messenger models which fully cover the parameter space of GGM. These examples demonstrate that the full parameter space of GGM is physical and realizable. Thus it should be considered a valid basis for future phenomenological explorations of gauge mediation.

  1. Mediated Cultural Memories

    DEFF Research Database (Denmark)

    Frølunde, Lisbeth; Bjerregaard, Mette

    2013-01-01

    culture as convergent with evolving genres. From a socio-cultural linguistic perspective, a standardization of meaning-making (Machin and van Leeuwen) affects our reading, viewing, sense of identity within families, culture, nation-states, and notions of enemy. In the discussion, we consider how mediated...

  2. Mediated intimacy in families

    DEFF Research Database (Denmark)

    Stougaard, Malthe Kirkhoff

    2006-01-01

    with other types of intimate relations such as strong-tie intimacy (couples cohabiting). However, we also identified several issues of intimacy unique to the special relation between children and their parents. These unique acts of intimacy propose challenges when designing technologies for mediated intimacy...

  3. Inflammatory mediators in osteoarthritis

    NARCIS (Netherlands)

    Beekhuizen, M.

    2014-01-01

    Osteoarthritis (OA) is a degenerative joint disorder involving cartilage destruction and joint inflammation. Despite extensive research, still much is unknown on the pathogenesis and aetiology of OA. Inflammation and inflammatory mediators (both local and systemic) are key in the pathogenesis of OA.

  4. Expanding mediation theory

    NARCIS (Netherlands)

    Verbeek, P.P.C.C.

    2012-01-01

    In his article In Between Us, Yoni van den Eede expands existing theories of mediation into the realm of the social and the political, focusing on the notions of opacity and transparency. His approach is rich and promising, but two pitfalls should be avoided. First, his concept of ‘in-between’ runs

  5. Thermally favourable gauge mediation

    International Nuclear Information System (INIS)

    We discuss the thermal evolution of the spurion and messenger fields of ordinary gauge mediation models taking into account the Standard Model degrees of freedom. It is shown that for thermalized messengers the metastable susy breaking vacuum becomes thermally selected provided that the susy breaking sector is sufficiently weakly coupled to messengers or to any other observable field.

  6. Den sundhedsfremmende mediator

    DEFF Research Database (Denmark)

    Læssøe, Jeppe

    2009-01-01

    mediering samt mellem forskellige mediator-roller og tilhørsforhold. Det er også vigtigt at være bevidst om de centrale kvaliteter, risici og dilemmaer, som mediering indebærer i forhold til involvering af borgerne. Denne artikel rummer et bud på en sådan nuanceret begrebsliggørelse og refleksion, relateret...

  7. Technology-Use Mediation

    DEFF Research Database (Denmark)

    Bansler, Jørgen P.; Havn, Erling C.

    2003-01-01

    This study analyzes how a group of ‘mediators’ in a large, multinational company adapted a computer-mediated communication technology (a ‘virtual workspace’) to the organizational context (and vice versa) by modifying features of the technology, providing ongoing support for users, and promoting...

  8. CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction

    OpenAIRE

    Tabeling, Christoph; Yu, Hanpo; Wang, Liming; Ranke, Hannes; Goldenberg, Neil M.; Zabini, Diana; Noe, Elena; Krauszman, Adrienn; Gutbier, Birgitt; Yin, Jun; Schaefer, Michael,; Arenz, Christoph; Hocke, Andreas C.; Suttorp, Norbert; Proia, Richard L.

    2015-01-01

    Hypoxic pulmonary vasoconstriction (HPV) is a physiological mechanism that protects against systemic hypoxemia by redistributing blood flow from poorly to better ventilated areas of the lung, thereby minimizing ventilation-perfusion mismatch. However, in chronic hypoxemia-associated lung disease, HPV contributes to pulmonary hypertension. In this study, we provide novel evidence for a dual role of sphingolipids as important signal mediators in HPV, which critically depends on the presence of ...

  9. 电穿孔介导的pIRES-hVEGF165-EGFP转染对牵引成骨过程中早期血管生成的影响%Effect of electroporation mediated transfecting recombinant plasmid pIRES-hVEGF165-EGFP on angiogene-sis of distraction area during early mandibular distraction osteogenesis

    Institute of Scientific and Technical Information of China (English)

    吴国平; 黎德平; 何小川; 李盛华; 杨智慧; 廖毅; 郭力

    2010-01-01

    目的 探讨电穿孔介导的基因治疗对下领骨牵引成骨过程中早期血管生成的影响.方法 32只新西兰大白兔随机分为4组:质粒+电穿孔组(A组),质粒组(B组),生理盐水+电穿孔组(C组),空白对照组(D组).各组动物分别于注射后1、3、7、14 d处死,取牵引区组织进行组织学检查、电镜观察、CD34免疫组织化学染色及微血管密度检测.结果 A、B组血管内皮细胞呈增殖活跃状态;C、D组多数血管内皮细胞部分呈现退变及凋亡早期改变.免疫组化染色发现,转染后第1天血管壁内皮细胞浆CD34表达较弱;第3、7、14天,牵引区肉芽组织血管内皮细胞均出现CD34阳性表达.A组CD34阳性表达较B组强,A、B组的CD34表达持续阳性且呈上升趋势;C、D组表达最弱,CD34阳性表达维持在第1天水平上平稳波动.结论 电穿孔介导的pIRES-hVEGF165-EGFP重组质粒体内转染能够促进牵引区早期微血管的生成,使局部血管增生、渗入,增加骨断端的血流量.对调节和促进骨的生长和修复过程具有重要作用.%Objective To explore the effect of electroporation mediated gene therapy on angiogene-sis of the distraction area during early mandibular distraction osteogenesis (DO). Methods Thirty-two New-Zeland rabbits were randomly divided into 4 groups: group A: recombinant plasmid pIRES-VEGF165-EGFP and electroporation; group B: recombinant plasmid pIRES-VEGF165-EGFP; group C: normal saline (NS) and electroporation and group D: control group. The rabbits were sacrificed at 1d, 3d, 7d and 14d after injection, respectively. The distraction area tissue was removed for histological examination and electron microscopy, and immunohistochemical stain for CD34 was performed to detect the microvessel density. Results Generation of vascular endothelial cells (VEC) in the group A and group B were active, and majority of VEC in groups C and D took on early change of cataplasia and apoptosis. The

  10. The Strategic Mediator

    DEFF Research Database (Denmark)

    Rossignoli, Cecilia; Carugati, Andrea; Mola, Lapo

    2009-01-01

    The last 10 years have witnessed the emergence of electronic marketplaces as players that leverage new technologies to facilitate B2B internet-mediated collaborative business. Nowadays these players are augmenting their services from simple intermediation to include new inter-organizational relat......The last 10 years have witnessed the emergence of electronic marketplaces as players that leverage new technologies to facilitate B2B internet-mediated collaborative business. Nowadays these players are augmenting their services from simple intermediation to include new inter...... as an exclusive club, the belonging to which provides a strategic advantage. The technology brought forth by the marketplace participates in shaping the strategic demands of the participants which in turn request the marketplace to redesign its own strategy. Profiting from this unintended demand, the e...

  11. Models as Mediators

    DEFF Research Database (Denmark)

    Sommerlund, Julie

    from laboratory studies, (Latour 1979; Lynch 1985; Sommerlund 2004 (2007); Sommerlund 2006) and is complemented by the attention paid to the "mediator" by Hennion (1989; 1997; 2005). The empirical focus will be on a central - but overlooked - actor of branding and advertising; the model. The model has...... solely been theorized within cultural studies (Craik 1994) as feminine spectacle, but has been neglected as mediator and actor. This paper will argue that models are co-producers of brands, and vice versa. Empirically, the paper will present interviews with models, model-scouts, agents, and advertisers....... Jacobs, Nancy Weiss. Oxford, Blackwell Publishing. Latour, B. W., Steve (1979). Laboratory Life. London, New Delhi, Sage. Lynch, M. (1985). Art and artifact in laboratory science. London, Boston, Melbourne and Henley, Routledge & Kegan Paul. Sommerlund, J. (2004 (2007)). "Beauty and Bacteria...

  12. Direct Gaugino Mediation

    International Nuclear Information System (INIS)

    We describe renormalizable supersymmetric four-dimensional theories which lead to gaugino mediation and various generalizations thereof. Even though these models are strongly coupled, we can demonstrate the parametric suppression of soft scalar masses via Seiberg duality. We show that our models have a parameter which continuously interpolates between suppressed soft scalar masses and their conventional gauge mediated contribution. The main physical effect which we utilize is the general relation between massive deformations in one frame and the Higgs mechanism in the dual frame. Some compelling and relatively unexplored phenomenological scenarios arise naturally in this framework. We offer preliminary comments on various aspects of the phenomenology and outline several of the outstanding open problems.

  13. Minimal gaugino mediation

    International Nuclear Information System (INIS)

    We propose minimal gaugino mediation as the simplest known solution to the supersymmetric flavor and CP problems. The framework predicts a very minimal structure for the soft parameters at ultrahigh energies: gaugino masses are unified and non-vanishing whereas all other soft supersymmetry breaking parameters vanish. We show that this boundary condition naturally arises from a small extra dimension and present a complete model which includes a new extra-dimensional solution to the μ problem. We briefly discuss the predicted superpartner spectrum as a function of the two parameters of the model. The commonly ignored renormalization group evolution above the GUT scale is crucial to the viability of minimal gaugino mediation but does not introduce new model dependence

  14. Minimal Gaugino Mediation

    International Nuclear Information System (INIS)

    The authors propose Minimal Gaugino Mediation as the simplest known solution to the supersymmetric flavor and CP problems. The framework predicts a very minimal structure for the soft parameters at ultra-high energies: gaugino masses are unified and non-vanishing whereas all other soft supersymmetry breaking parameters vanish. The authors show that this boundary condition naturally arises from a small extra dimension and present a complete model which includes a new extra-dimensional solution to the mu problem. The authors briefly discuss the predicted superpartner spectrum as a function of the two parameters of the model. The commonly ignored renormalization group evolution above the GUT scale is crucial to the viability of Minimal Gaugino Mediation but does not introduce new model dependence

  15. Amplitude mediated chimera states

    OpenAIRE

    Sethia, Gautam C.; Sen, Abhijit; Johnston, George L.

    2013-01-01

    We investigate the possibility of obtaining chimera state solutions of the non-local Complex Ginzburg-Landau Equation (NLCGLE) in the strong coupling limit when it is important to retain amplitude variations. Our numerical studies reveal the existence of a variety of amplitude mediated chimera states (including stationary and non-stationary two cluster chimera states), that display intermittent emergence and decay of amplitude dips in their phase incoherent regions. The existence regions of t...

  16. 45 CFR 16.18 - Mediation.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Mediation. 16.18 Section 16.18 Public Welfare... BOARD § 16.18 Mediation. (a) In cases pending before the Board. If the Board decides that mediation... mediation techniques and will provide or assist in selecting a mediator. The mediator may take any...

  17. Teachers as mediators

    DEFF Research Database (Denmark)

    Dorf, Hans; Kelly, Peter; Hohmann, Ulrike;

    2012-01-01

    and cultural influences on practice. Yet the teachers observed moved smoothly between goal-oriented behaviours in a continuous and comfortable style, easily and without reflecting any tensions between them. Thus, this article elaborates an account of situated English teaching.......Within the context of lower secondary English teaching in South West England, this study identifies in broad terms the competing goals between which English teachers mediate and the explicit and hidden tensions that result. To understand the interactions of competing goals, teachers’ goal...

  18. Mediatization and Government Communication

    DEFF Research Database (Denmark)

    Laursen, Bo; Valentini, Chiara

    2015-01-01

    in the light of mediatization and government communication theories. Without one pan-European public sphere, the European Parliament, like the other European Union (EU) institutions, competes with national actors for the news media’s attention in the EU’s twenty-eight national public spheres, where EU affairs......” in their communication efforts, and that they face a daily professional challenge as they attempt to promote the European Parliament and its activities to the news media in a way that will not compromise their credibility as government sources. The study provides new insights into communicative aspects of EU governance...

  19. Ferrofluid mediated nanocytometry.

    Science.gov (United States)

    Kose, Ayse Rezzan; Koser, Hur

    2012-01-01

    We present a low-cost, flow-through nanocytometer that utilizes a colloidal suspension of non-functionalized magnetic nanoparticles for label-free manipulation and separation of microparticles. Our size-based separation is mediated by angular momentum transfer from magnetically excited ferrofluid particles to microparticles. The nanocytometer is capable of rapidly sorting and focusing two or more species, with up to 99% separation efficiency and a throughput of 3 × 10(4) particles/s per mm(2) of channel cross-section. The device is readily scalable and applicable to live cell sorting with biocompatible ferrofluids, offering competitive cytometer performance in a simple and inexpensive package. PMID:22076536

  20. Mediation Revisited: The Interactive Organization of Mediation in Learning Environments

    OpenAIRE

    Pekarek Doehler, Simona

    2013-01-01

    This article is concerned with the social organization of mediation in learning environments. It seeks to further articulate the sociocultural notion of mediation in sociointeractional terms, combining insights from the sociocultural approach to cognition and the microinteractionist, especially ethnomethodological approach to social activities. A microanalysis of mediation in communicative 2nd-language classroom activities where the task at hand is the management of interaction itself is pres...

  1. Enable, mediate, advocate.

    Science.gov (United States)

    Saan, Hans; Wise, Marilyn

    2011-12-01

    The authors of the Ottawa Charter selected the words enable, mediate and advocate to describe the core activities in what was, in 1986, the new Public Health. This article considers these concepts and the values and ideas upon which they were based. We discuss their relevance in the current context within which health promotion is being conducted, and discuss the implications of changes in the health agenda, media and globalization for practice. We consider developments within health promotion since 1986: its central role in policy rhetoric, the increasing understanding of complexities and the interlinkage with many other societal processes. So the three core activities are reviewed: they still fit well with the main health promotion challenges, but should be refreshed by new ideas and values. As the role of health promotion in the political arena has grown we have become part of the policy establishment and that is a mixed blessing. Making way for community advocates is now our challenge. Enabling requires greater sensitivity to power relations involved and an understanding of the role of health literacy. Mediating keeps its central role as it bridges vital interests of parties. We conclude that these core concepts in the Ottawa Charter need no serious revision. There are, however, lessons from the last 25 years that point to ways to address present and future challenges with greater sensitivity and effectiveness. We invite the next generation to avoid canonizing this text: as is true of every heritage, the heirs must decide on its use. PMID:22080073

  2. The Simulation of the Influenza Transmission Dynamics in Tropical Area and Subtropical Area in East Asia

    Institute of Scientific and Technical Information of China (English)

    YANG Gong-li

    2014-01-01

    The underlying theory of the summer influenza transmission peaks in tropical area and subtropical area in East Asia is still unclear. We built an agent-based model (ABM) to simulate the influenza transmission dynamics. We modeled two main routes of influenza transmission in the model: the aerosol route and the fomite-mediated route. Our results show that the absolute humidity (AH) is strikingly associated with the influenza transmission in different season; Fomite-mediated route particularly plays an important role in influenza transmission, the two-route transmission model can be better used for explaining the summer transmission peaks.

  3. Semi-direct gauge mediation

    International Nuclear Information System (INIS)

    We describe a framework for gauge mediation of supersymmetry breaking in which the messengers are charged under the hidden sector gauge group but do not play a role in breaking supersymmetry. From this point of view, our framework is between ordinary gauge mediation and direct mediation. As an example, we consider the 3-2 model of dynamical supersymmetry breaking, and add to it massive messengers which are SU(2) doublets. We briefly discuss the phenomenology of this scenario.

  4. Mediating Trust in Terrorism Coverage

    DEFF Research Database (Denmark)

    Mogensen, Kirsten

    crisis. While the framework is presented in the context of television coverage of a terror-related crisis situation, it can equally be used in connection with all other forms of mediated trust. Key words: National crisis, risk communication, crisis management, television coverage, mediated trust.......Mass mediated risk communication can contribute to perceptions of threats and fear of “others” and/or to perceptions of trust in fellow citizens and society to overcome problems. This paper outlines a cross-disciplinary holistic framework for research in mediated trust building during an acute...

  5. When Memories are Mediated

    DEFF Research Database (Denmark)

    Frølunde, Lisbeth; Bjerregaard, Mette

    2013-01-01

    Acts of mass violence, including murder on civilians, genocide, oppression and wars, can mobilize memories of the involved persons and following generations in a certain historical situation. Acts of mass violence can also create a sort of looking glass of culturally dominant memories that are...... political contexts and media platforms take place and become contexts for audience reception. This paper explores two examples of narratives that construct memories of acts of mass violence: “Gzim Rewind” (Sweden, 2011, director Knutte Wester) about 1990’s Kosovo, and “The Act of Killing” (Denmark, 2012...... mediated through stories: told and retold as oral stories through generations, as myths or sagas, or remediated as contemporary documentary film accounts or more fictional film accounts. In these processes of retelling acts of violence, transformations of meanings across time, cultural, social and...

  6. Neutrino assisted gauge mediation

    International Nuclear Information System (INIS)

    Recent observation shows that the Higgs mass is at around 125 GeV while the prediction of the minimal supersymmetric standard model is below 120 GeV for stop mass lighter than 2 TeV unless the top squark has a maximal mixing. We consider the right-handed neutrino supermultiplets as messengers in addition to the usual gauge mediation to obtain sizeable trilinear soft parameters At needed for the maximal stop mixing. Neutrino messengers can explain the observed Higgs mass for stop mass around 1 TeV. Neutrino assistance can also generate charged lepton flavor violation including μ→e γ as a possible signature of the neutrino messengers. We consider the S4 discrete flavor model and show the relation of the charged lepton flavor violation, θ 13 of neutrino oscillation and the muon's g-2. (orig.)

  7. The mediation procedure in Romania

    Directory of Open Access Journals (Sweden)

    Alexandrina Zaharia

    2009-06-01

    Full Text Available The mediation activity as an alternative way of solving conflicts occupies an important place in modernsociety. Currently, the mediation reached its maturity worldwide being adopted without reservations.The future of solving conflicts is undoubtedly closely related to mediation. XXth century is the century of solvingconflicts amiably outside the court room. In Romania and the mediation profession were regulated by the Law no.192/2006, on the basis of the idea that mediation is one of the major themes of the reform strategy of the judicialsystem 2005-2007. By adopting the mentioned law it was followed the idea of reducing the volume of activitycourts, and therefore, relieve them of as many cases, with the direct effect on the quality of justice. Mediation is avoluntary process in which the parties with a neutral and impartial third party, without power of decision - themediator - who is qualified to assist the parties to negotiate, facilitating the communication between them andhelping them to reach a unanimous effective and sustainable agreement. The parties may resort to mediation beforeor after triggering a trial. Mediation can be applied, in principle, on any type of conflict. However, theRomanian legislator has established special stipulations on conflict mediation in criminal, civil and familylaw. Although not expressly provided, the stipulations regarding the civil conflicts and also apply to commercialconflicts. Therefore, the mediation is applicable to most types of lawsuits, except those relating to personalrights. As a "win- win" principle, the mediation does not convert any of the parties defeated or victorious; allthose involved have gained by applying this procedure.

  8. Mediating Trust in Terrorism Coverage

    DEFF Research Database (Denmark)

    Mogensen, Kirsten

    crisis. While the framework is presented in the context of television coverage of a terror-related crisis situation, it can equally be used in connection with all other forms of mediated trust. Key words: National crisis, risk communication, crisis management, television coverage, mediated trust....

  9. Peer Mediation in Elementary Schools.

    Science.gov (United States)

    Angaran, Sally; Beckwith, Kathy

    1999-01-01

    Minor disagreements can quickly escalate when a child feels threatened with losing face or fears retaliation. Peer-mediation programs can help students refocus their energies while learning communication skills they can use in other situations. The benefits of an Oregon elementary school's peer-mediation program are discussed. (MLH)

  10. Anomaly mediation deformed by axion

    International Nuclear Information System (INIS)

    We show that in supersymmetric axion models the axion supermultiplet obtains a sizable F-term due to a non-supersymmetric dynamics and it generally gives the gaugino masses comparable to the anomaly mediation contribution. Thus the gaugino mass relation predicted by the anomaly mediation effect can be significantly modified in the presence of axion to solve the strong CP problem

  11. FHFA Underserved Areas

    Data.gov (United States)

    Department of Housing and Urban Development — Federal Housing Finance Agency's (FHFA) Underserved Areas establishes underserved area designations for census tracts in Metropolitan Areas (MSAs), nonmetropolitan...

  12. Practical Guide to Civil Mediation

    CERN Multimedia

    2006-01-01

    The Permanent Mission of Switzerland has informed CERN that the Département des Institutions of the Republic and Canton of Geneva and the Groupement suisse des Magistrats pour la médiation (GEMME) - Swiss Association of Magistrates for Mediation have published a multilingual Practical Guide to Civil Mediation (including English). In this context, the Swiss Mission has underlined the benefits of resorting to mediation, especially for the personnel of International Organizations, and which the Secretary-General of the GEMME has summarised as follows: it is a private process not requiring the waiver of the parties' immunities; the confidentiality of the mediation process is guaranteed both by the mediator and the parties to it; the search for an amicable settlement does not need to be determined by reference to law (provided that public order is respected); the process is faster (2 to 3 sessions), less costly and more flexible than civil or arbitration procedures; in order to reinforce the agreem...

  13. Practical Guide to Civil Mediation

    CERN Multimedia

    2006-01-01

    The Permanent Mission of Switzerland has informed CERN that the Département des Institutions of the Republic and Canton of Geneva and the Groupement suisse des Magistrats pour la médiation (GEMME) - Swiss Association of Magistrates for Mediation have published a multilingual Practical Guide to Civil Mediation (including English). In this context, the Swiss Mission has underlined the benefits of resorting to mediation, especially for the personnel of international organizations, and which the Secretary-General of the GEMME has summarised as follows: it is a private process not requiring the waiver of the parties' immunities; the confidentiality of the mediation process is guaranteed both by the mediator and the parties to it; the search for an amicable settlement does not need to be determined by reference to law (provided that public order is respected); the process is faster (2 to 3 sessions), less costly and more flexible than civil or arbitration procedures; in order to reinforce the agreeme...

  14. Comments on general gauge mediation

    International Nuclear Information System (INIS)

    There has been interest in generalizing models of gauge mediation of supersymmetry breaking. As shown by Meade, Seiberg, and Shih (MSS), the soft masses of general gauge mediation can be expressed in terms of the current two-point functions of the susy-breaking sector. We here give a simple extension of their result which provides, for general gauge mediation, the full effective potential for squark pseudo-D-flat directions. The effective potential reduces to the sfermion soft masses near the origin, and the full potential, away from the origin, can be useful for cosmological applications. We also generalize the soft masses and effective potential to allow for general gauge mediation by Higgsed gauge groups. Finally, we discuss general gauge mediation in the limit of small F-terms, and how the results of MSS connect with the analytic continuation in superspace results, based on a spurion analysis.

  15. 29 CFR 1203.1 - Mediation services.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Mediation services. 1203.1 Section 1203.1 Labor Regulations Relating to Labor (Continued) NATIONAL MEDIATION BOARD APPLICATIONS FOR SERVICE § 1203.1 Mediation services. Applications for the mediation services of the National Mediation Board under section 5, First, of the...

  16. 29 CFR 35.32 - Mediation.

    Science.gov (United States)

    2010-07-01

    ... Mediation. (a) Referral to mediation. CRC will promptly refer to the Federal Mediation and Conciliation Service or the mediation agency designated by the Secretary of Health and Human Services under 45 CFR part... 29 Labor 1 2010-07-01 2010-07-01 true Mediation. 35.32 Section 35.32 Labor Office of the...

  17. 29 CFR 1202.1 - Mediation.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Mediation. 1202.1 Section 1202.1 Labor Regulations Relating to Labor (Continued) NATIONAL MEDIATION BOARD RULES OF PROCEDURE § 1202.1 Mediation. The mediation..., or where conferences are refused. The National Mediation Board may proffer its services in case...

  18. 34 CFR 81.13 - Mediation.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Mediation. 81.13 Section 81.13 Education Office of the... Mediation. (a) Voluntary mediation is available for proceedings that are pending before the OALJ. (b) A... mediation by filing a motion with the ALJ assigned to the case. The OALJ arranges for a mediator if...

  19. 24 CFR 3288.35 - Mediation.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Mediation. 3288.35 Section 3288.35...-Administered States § 3288.35 Mediation. (a) Mediator. The dispute resolution provider will provide for the... identifies any other party that should be included in the mediation, the mediator will contact the...

  20. 32 CFR 776.38 - Mediation.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Mediation. 776.38 Section 776.38 National... Professional Conduct § 776.38 Mediation. (a) Mediation: (1) A covered attorney may act as a mediator between... mediation, including the advantages and risks involved, and the effect on the...

  1. 44 CFR 7.942 - Mediation.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Mediation. 7.942 Section 7..., Conciliation, and Enforcement Procedures § 7.942 Mediation. (a) FEMA will promptly refer to a mediation agency... participate in the mediation process to the extent necessary to reach an agreement or for the mediator to...

  2. 22 CFR 143.33 - Mediation.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Mediation. 143.33 Section 143.33 Foreign... Mediation. (a) Referral of complaints for mediation. The agency will refer to the Federal Mediation and... participate in the mediation process to the extent necessary to reach an agreement or make an...

  3. Structure-mediated nanoscopy

    DEFF Research Database (Denmark)

    Glückstad, Jesper; Bañas, Andrew Rafael; Aabo, Thomas;

    2013-01-01

    The science fiction inspired shrinking of macro-scale robotic manipulation and handling down to the micro- and nano-scale regime open new doors for exploiting the forces and torques of light for micro- and nanobiologic probing, actuation and control [1]. Advancing light-driven micro-robotics requ...... light for the strongly emerging areas of neurophotonics and optogenetics....

  4. Microbially mediated mineral carbonation

    Science.gov (United States)

    Power, I. M.; Wilson, S. A.; Dipple, G. M.; Southam, G.

    2010-12-01

    Mineral carbonation involves silicate dissolution and carbonate precipitation, which are both natural processes that microorganisms are able to mediate in near surface environments (Ferris et al., 1994; Eq. 1). (Ca,Mg)SiO3 + 2H2CO3 + H2O → (Ca,Mg)CO3 + H2O + H4SiO4 + O2 (1) Cyanobacteria are photoautotrophs with cell surface characteristics and metabolic processes involving inorganic carbon that can induce carbonate precipitation. This occurs partly by concentrating cations within their net-negative cell envelope and through the alkalinization of their microenvironment (Thompson & Ferris, 1990). Regions with mafic and ultramafic bedrock, such as near Atlin, British Columbia, Canada, represent the best potential sources of feedstocks for mineral carbonation. The hydromagnesite playas near Atlin are a natural biogeochemical model for the carbonation of magnesium silicate minerals (Power et al., 2009). Field-based studies at Atlin and corroborating laboratory experiments demonstrate the ability of a microbial consortium dominated by filamentous cyanobacteria to induce the precipitation of carbonate minerals. Phototrophic microbes, such as cyanobacteria, have been proposed as a means for producing biodiesel and other value added products because of their efficiency as solar collectors and low requirement for valuable, cultivable land in comparison to crops (Dismukes et al., 2008). Carbonate precipitation and biomass production could be facilitated using specifically designed ponds to collect waters rich in dissolved cations (e.g., Mg2+ and Ca2+), which would allow for evapoconcentration and provide an appropriate environment for growth of cyanobacteria. Microbially mediated carbonate precipitation does not require large quantities of energy or chemicals needed for industrial systems that have been proposed for rapid carbon capture and storage via mineral carbonation (e.g., Lackner et al., 1995). Therefore, this biogeochemical approach may represent a readily

  5. Caspases: An apoptosis mediator

    Directory of Open Access Journals (Sweden)

    Tapan Kumar Palai

    2015-03-01

    Full Text Available The process of programmed cell death, or apoptosis, is generally characterized by distinct morphological characteristics and energy - dependent biochemical mechanisms. Apoptosis is a widely conserved phenomenon helping many processes, including normal cell turnover, proper development and functioning of the immune system, hormone dependent atrophy etc. Inappropriate apoptosis (either low level or high level leads to many developmental abnormalities like, neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of cancer. To use cells for therapeutic purposes through generating cell lines, it is critical to study the cell cycle machinery and signalling pathways that controls cell death and apoptosis. Apoptotic pathways provide a fundamental protective mechanism that decreases cellular sensitivity to damaging events and allow proper developmental process in multi-cellular organisms. Major mediator of apoptosis is a family of proteins known as caspases. There are mainly fourteen types of caspases but out of them only ten caspasese have got essential role in controlling the process of apoptosis. These ten caspases have been categorized into either initiator caspases (caspase 2, 8, 9, 10 or executioner caspases (caspase 3, 6, 7. Although various types of caspases have been identified so far, the exact mechanisms of action of these groups of proteins is still to be fully understood. The aim of this review is to provide a detail overview of role of different caspases in regulating the process of apoptosis.

  6. Ultrasound mediated gene transfection

    Science.gov (United States)

    Williamson, Rene G.; Apfel, Robert E.; Brandsma, Janet L.

    2002-05-01

    Gene therapy is a promising modality for the treatment of a variety of human diseases both inherited and acquired, such as cystic fibrosis and cancer. The lack of an effective, safe method for the delivery of foreign genes into the cells, a process known as transfection, limits this effort. Ultrasound mediated gene transfection is an attractive method for gene delivery since it is a noninvasive technique, does not introduce any viral particles into the host and can offer very good temporal and spatial control. Previous investigators have shown that sonication increases transfection efficiency with and without ultrasound contrast agents. The mechanism is believed to be via a cavitation process where collapsing bubble nuclei permeabilize the cell membrane leading to increased DNA transfer. The research is focused on the use of pulsed wave high frequency focused ultrasound to transfect DNA into mammalian cells in vitro and in vivo. A better understanding of the mechanism behind the transfection process is also sought. A summary of some in vitro results to date will be presented, which includes the design of a sonication chamber that allows us to model the in vivo case more accurately.

  7. Assay of mast cell mediators

    DEFF Research Database (Denmark)

    Rådinger, Madeleine; Jensen, Bettina M; Swindle, Emily;

    2015-01-01

    Mediator release from activated mast cells is a major initiator of the symptomology associated with allergic disorders such as anaphylaxis and asthma. Thus, methods to monitor the generation and release of such mediators have widespread applicability in studies designed to understand the processes...... regulating mast cell activation and for the identification of therapeutic approaches to block mast cell-driven disease. In this chapter, we discuss approaches used for the determination of mast cell degranulation, lipid-derived inflammatory mediator production, and cytokine/chemokine gene expression as well...

  8. Doing statistical mediation and moderation

    CERN Document Server

    Jose, Paul E

    2013-01-01

    Written in a friendly, conversational style, this book offers a hands-on approach to statistical mediation and moderation for both beginning researchers and those familiar with modeling. Starting with a gentle review of regression-based analysis, Paul Jose covers basic mediation and moderation techniques before moving on to advanced topics in multilevel modeling, structural equation modeling, and hybrid combinations, such as moderated mediation. User-friendly features include numerous graphs and carefully worked-through examples; ""Helpful Suggestions"" about procedures and pitfalls; ""Knowled

  9. Gauge mediation in string theory

    OpenAIRE

    Kawano, Teruhiko; Ooguri, Hirosi; Ookouchi, Yutaka

    2007-01-01

    We show that a large class of phenomenologically viable models for gauge mediation of supersymmetry breaking based on meta-stable vacua can be realized in local Calabi–Yau compactifications of string theory.

  10. Mediator-Generated Pressure Tactics

    Science.gov (United States)

    Byrnes, Joseph F.

    1978-01-01

    Two examples of bluff pressures (as opposed to real pressures) used by mediators to effect contract settlements are presented, along with advice to negotiators on avoiding or minimizing such tactics. (Author/IRT)

  11. A leitura mediada como estratégia de cuidado lúdico: contribuição ao campo da enfermagem fundamental La lectura mediada como atención lúdica: contribución al campo de la enfermería básica The mediate reading as a ludic care strategy: Contribution to the basic nursing area

    Directory of Open Access Journals (Sweden)

    Lívia Rodrigues Mendes

    2009-09-01

    cuidados y atención se concretizan como los principios de la teoría del cuidado humano y, también, del Proyecto Humaniza SUS, cuyas estrategias de acoger al paciente están ganando cada dia más importancia.The purpose is the mediated reading to hospitalized child as "ludic" strategy. The objectives are: Identify the meanings of reading mediation actions attributed by the subjects; characterize their contributions to hospitalized children, and discuss the mediated reading as expressive / "ludic" strategy of basic care. It is a descriptive and qualitative study conducted with 10 hospitalized children and their 10 escorts; 07 reading mediators, and 10 nursing team's members. The benefits of reading were evidenced on children and their escort's well-being which promote the health team's work. For the professionals and mediators, the mediated reading is a humanization care strategy that reduce psychic surcharge and provides emotional comfort to the children, softening their suffering. It concluded that combining "ludism" and care is in line with the principles of the theory of human care and also the project called Humaniza SUS, whose host strategies of customer are valued.

  12. 24 CFR 146.35 - Mediation.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Mediation. 146.35 Section 146.35... ASSISTANCE Investigation, Settlement, and Enforcement Procedures § 146.35 Mediation. (a) HUD shall refer to the Federal Mediation and Conciliation Service, a mediation agency designated by the Secretary...

  13. 7 CFR 780.9 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Mediation. 780.9 Section 780.9 Agriculture Regulations... PROGRAMS APPEAL REGULATIONS § 780.9 Mediation. (a) Any request for mediation must be submitted after... once: (1) If resolution of an adverse decision is not achieved in mediation, a participant may...

  14. 22 CFR 218.33 - Mediation.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Mediation. 218.33 Section 218.33 Foreign... § 218.33 Mediation. (a) Referral of complaints for mediation. The agency will refer to the Federal Mediation and Conciliation Service all complaints that: (1) fall within the jurisdiction of...

  15. 45 CFR 1156.16 - Mediation.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Mediation. 1156.16 Section 1156.16 Public Welfare... Procedures § 1156.16 Mediation. (a) Referral of complaints for mediation. The Endowment will promptly refer all complaints to the agency designated by the Secretary of HHS to manage the mediation process...

  16. Mediation in Schools: Tapping the Potential

    Science.gov (United States)

    Hendry, Richard

    2010-01-01

    This article explores the developing role of mediation as a conflict resolution process in schools. It gives an accepted definition and clarifies the purposes of mediation, outlining the range of contexts in and beyond schools in which mediation is already offered as a formal intervention. The typical process of mediation itself is described. The…

  17. 15 CFR 20.12 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Mediation. 20.12 Section 20.12... Procedures § 20.12 Mediation. (a) DOC will refer to a mediation service designated by the Secretary all... further processing. (b) Both the complainant and the recipient shall participate in the mediation...

  18. 15 CFR 930.111 - OCRM mediation.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false OCRM mediation. 930.111 Section 930... FEDERAL CONSISTENCY WITH APPROVED COASTAL MANAGEMENT PROGRAMS Secretarial Mediation § 930.111 OCRM mediation. The availability of mediation does not preclude use by the parties of alternative means...

  19. 10 CFR 4.333 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Mediation. 4.333 Section 4.333 Energy NUCLEAR REGULATORY... Investigation, Conciliation, and Enforcement Procedures § 4.333 Mediation. (a) Referral of complaints for mediation. NRC will refer to a mediation agency designated by the Secretary of the Department of Health...

  20. 10 CFR 1040.89-6 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... Enforcement Procedures § 1040.89-6 Mediation. (a) Referral of complaints for mediation. DOE will refer to the Federal Mediation and Conciliation Service, in accordance with 45 CFR 90.43(c)(3), all complaints that: (1... 10 Energy 4 2010-01-01 2010-01-01 false Mediation. 1040.89-6 Section 1040.89-6 Energy...

  1. 38 CFR 18.543 - Mediation.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Mediation. 18.543 Section... Enforcement Procedures § 18.543 Mediation. (a) Referral of complaints for mediation. VA will refer to the Federal Mediation and Conciliation Service all complaints that: (1) Fall within the jurisdiction of...

  2. 34 CFR 110.32 - Mediation.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Mediation. 110.32 Section 110.32 Education Regulations..., Conciliation, and Enforcement Procedures § 110.32 Mediation. (a) ED promptly refers to the Federal Mediation and Conciliation Service or to the mediation agency designated by the Secretary of Health and...

  3. 45 CFR 91.43 - Mediation.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Mediation. 91.43 Section 91.43 Public Welfare... Enforcement Procedures § 91.43 Mediation. (a) HHS will promptly refer to a mediation agency designated by the... mediation process to the extent necessary to reach an agreement or make an informed judgment that...

  4. 14 CFR 1252.402 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Mediation. 1252.402 Section 1252.402... Procedures § 1252.402 Mediation. (a) Referral of complaints for mediation. NASA will refer to the Federal Mediation and Conciliation Service all complaints that: (1) Fall within the jurisdiction of the Act...

  5. 43 CFR 17.332 - Mediation.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Mediation. 17.332 Section 17.332 Public..., and Enforcement Procedures § 17.332 Mediation. (a) Referral of complaints for mediation. DOI will... participate in the mediation process to the extent necessary to reach an agreement or make an...

  6. 15 CFR 923.54 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Mediation. 923.54 Section 923.54... Mediation. (a) Section 307(h) of the Act provides for mediation of serious disagreement between any Federal... cases, mediation by the Secretary, with the assistance of the Executive Office of the President, may...

  7. 7 CFR 614.11 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Mediation. 614.11 Section 614.11 Agriculture... AGRICULTURE CONSERVATION OPERATIONS NRCS APPEAL PROCEDURES § 614.11 Mediation. (a) A participant who wishes to pursue mediation must file request for mediation under this part with the NRCS official designated in...

  8. Neutrality in mediation: an ambiguous ethical value

    OpenAIRE

    Bailey, Paul

    2014-01-01

    Mediator neutrality would appear, by definition, to be a necessary and required ethical principle for all mediators to practice. But what is meant by neutrality in mediation? Is it practically possible to be completely neutral between parties in mediation while at the same time being fair to both of them? This paper attempts to answer these two questions.

  9. Carbon mediated catalysis:A review on oxidative dehydrogenation

    Institute of Scientific and Technical Information of China (English)

    De Chen; Anders Holmen; Zhijun Sui; Xinggui Zhou

    2014-01-01

    Carbon mediated catalysis has gained an increasing attention in both areas of nanocatalysis and nanomaterials. The progress in carbon nanomaterials provides many new opportunities to manip-ulate the types and properties of active sites of catalysts through manipulating structures, function-alities and properties of carbon surfaces. The present review focuses on progresses in carbon medi-ated oxidative dehydrogenation reactions of ethylbenzene, propane, and butane. The state-of-the-art of the developments of carbon mediated catalysis is discussed in terms of fundamental studies on adsorption of oxygen and hydrocarbons, reaction mechanism as well as effects of carbon nano-material structures and surface functional groups on the catalytic performance. We highlight the importance and challenges in tuning of the electron density of carbon and oxygen on carbon surfac-es for improving selectivity in oxidative dehydrogenation reactions.

  10. Gaugino-Assisted Anomaly Mediation

    International Nuclear Information System (INIS)

    We present a model of supersymmetry breaking mediated through a small extra dimension. Standard model matter multiplets and a supersymmetry-breaking (or ''hidden'') sector are confined to opposite four-dimensional boundaries while gauge multiplets live in the bulk. The hidden sector does not contain a singlet and the dominant contribution to gaugino masses is via anomaly-mediated supersymmetry breaking. Scalar masses get contributions from both anomaly mediation and a tiny hard breaking of supersymmetry by operators on the hidden-sector boundary. These operators contribute to scalar masses at one loop and in most of parameter space, their contribution dominates. Thus it is easy to make all squared scalar masses positive. As no additional fields or symmetries are required below the Planck scale, we consider this the simplest working model of anomaly mediation. The gaugino spectrum is left untouched and the phenomenology of the model is roughly similar to anomaly mediated supersymmetry breaking with a universal scalar mass added. We identify the main differences in the spectrum between this model and other approaches. We also discuss mechanisms for generating the μ term and constraints on additional bulk fields. (author)

  11. Gaugino-assisted anomaly mediation

    International Nuclear Information System (INIS)

    I present a model of supersymmetry breaking mediated through a small extra dimension. Standard model matter multiplets and a supersymmetry-breaking (or 'hidden') sector are confined to opposite four-dimensional boundaries while gauge multiplets live in the bulk. The hidden sector does not contain a singlet and the dominant contribution to gaugino masses is via anomaly-mediated supersymmetry breaking. Scalar masses get contributions from both anomaly mediation and a tiny hard breaking of supersymmetry by operators on the hidden-sector boundary. These operators contribute to scalar masses at one loop and in most of parameter space, their contribution dominates. Thus it is easy to make all squared scalar masses positive. As no additional fields or symmetries are required below the Planck scale, this is among the simplest working models of anomaly mediation. The gaugino spectrum is left untouched and the phenomenology of the model is roughly similar to anomaly mediated supersymmetry breaking with a universal scalar mass added. Finally, the main differences in the spectrum between this model and other approaches are identified. This talk is based on work [1] done in collaboration with David E. Kaplan

  12. A Graphical Representation of the Mediated Effect

    OpenAIRE

    Fritz, Matthew S.; David P. MacKinnon

    2008-01-01

    Mediation analysis is widely used in the social sciences. Despite the popularity of mediation models, few researchers have used graphical methods, other than structural path diagrams, to represent their models. Plots of the mediated effect can help a researcher better understand the results of the analysis and convey these results to others. This article presents a method for creating and interpreting plots of the mediated effect for a variety of mediation models, including models with a dich...

  13. Nursing as textually mediated reality.

    Science.gov (United States)

    Cheek, J; Rudge, T

    1994-11-01

    Nursing and nursing practice both construct and are in turn constructed by the context in which they operate. Texts plays a central part in that construction. As such, nursing and nursing practice can be considered to represent a reality that is textually mediated. This paper explores the notion of nursing as a textually mediated reality and offers the reader the possibility of engaging in reflection on what implications this has for nursing and their own nursing practice. The analyses provided draw on aspects of the work of both Foucault and Derrida. Foucault's notion of discourse provides a vehicle for the exploration of nursing as textually mediated, as does Derrida's concept of binary oppositions. The paper thus illustrates some of the possibilities afforded nursing by poststructural analyses. In particular it does this by exploring one of the central textual constructions, impacting on the way that nursing and nursing practice are conceptualized, the mind/body binary opposition. PMID:7850620

  14. Gauge Mediated Mini-Split

    CERN Document Server

    Cohen, Timothy; Knapen, Simon

    2015-01-01

    We propose a simple model of split supersymmetry from gauge mediation. This model features gauginos that are parametrically a loop factor lighter than scalars, accommodates a Higgs boson mass of 125 GeV, and incorporates a simple solution to the $\\mu-b_\\mu$ problem. The gaugino mass suppression can be understood as resulting from collective symmetry breaking. Imposing collider bounds on $\\mu$ and requiring viable electroweak symmetry breaking implies small $a$-terms and small $\\tan \\beta$ -- the stop mass ranges from $10^5$ to $10^8 \\mbox{ GeV}$. In contrast with models with anomaly + gravity mediation (which also predict a one-loop loop suppression for gaugino masses), our gauge mediated scenario predicts aligned squark masses and a gravitino LSP. Gluinos, electroweakinos and Higgsinos can be accessible at the LHC and/or future colliders for a wide region of the allowed parameter space.

  15. Three tasks for mediatization research

    DEFF Research Database (Denmark)

    Ekstrøm, Mats; Fornäs, Johan; Jansson, André;

    2016-01-01

    Based on the interdisciplinary experience of a Swedish research committee, this article discusses critical conceptual issues raised by the current debate on mediatization – a concept that holds great potential to constitute a space for synthesized understandings of media-related social...... that mediatization researchers have sometimes formulated too grand claims as to mediatization’s status as a unitary approach, a meta-theory or a paradigm. Such claims have led to problematic confusions around the concept and should be abandoned in favour of a more open agenda. In line with such a call for openness...... transformations. In contrast to other, more metaphorical constructions, mediatization can be studied empirically in systematic ways through various sub-processes that together provide a complex picture of how culture and everyday life evolve in times of media saturation. The first part of this article argues...

  16. Mediation in Legal English Teaching

    Directory of Open Access Journals (Sweden)

    Chovancová Barbora

    2016-06-01

    Full Text Available Mediation is a language activity that has been unjustly neglected when preparing law students for their future professional careers. When trained in a professional context, students need to develop and improve complex communicative skills. These include not only the traditional language skills such as reading, writing, listening and speaking, but also more advanced skills such as summarizing, providing definitions, changing registers etc. All these are involved in the students’ acquisition of ‘soft skills’ that are particularly important for students of law since much of their future work involves interpersonal lawyer-client interaction. This article argues that mediation is a crucial (though previously underestimated skill and that law-oriented ESP instruction should provide training aimed at developing this skill. Showing a practical application of this approach, the paper demonstrates that mediation can be successfully integrated in the legal English syllabus and make the learning of legal English more effective.

  17. Family education and television mediation

    Directory of Open Access Journals (Sweden)

    Paz CÁNOVAS LEONHARDT

    2010-07-01

    Full Text Available This article try to deal with the complex influence of television viewing in the process of socialization of children and adolescents, focusing our attention on the importance of the family as the mediator-educator agency of particular relevance. Once analyzed the basic theoretical assumptions, we deepened in reality under study by providing data about how the studied population lives television and what extent parental mediation influences and affects the process. The article concludes with some reflections and pedagogical suggestions which trying to help to the optimization of the educational reality.

  18. Playful mediation and virtual sociality

    Directory of Open Access Journals (Sweden)

    Sihem NAJJAR

    2010-01-01

    Full Text Available As a space of sociability, virtual games, especially online role playing games, allow us to capture the interest of the playfulness in social life, but they are means by which users are able to experiment their relationship to others. The virtual games as a mediation device, constitute a "pretext" to forge friendships, develop love relationships, improve language skills, discover other cultures, etc. Based on a sociological survey of Tunisian Internet users (both sexes fans of virtual games we try to show how playful mediation is producing a multifaceted virtual sociality inherent in our contemporary societies.

  19. Secure mediated certificateless signature scheme

    Institute of Scientific and Technical Information of China (English)

    YANG Chen; MA Wen-ping; WANG Xin-mei

    2007-01-01

    Ju et al proposed a certificateless signature scheme with instantaneous revocation by introducing security mediator (SEM) mechanism. This article presents a detailed cryptoanalysis of this scheme and shows that, in their proposed scheme, once a valid signature has been produced, the signer can recover his private key information and the instantaneous revocation property will be damaged. Furthermore, an improved mediated signature scheme, which can eliminate these disadvantages, is proposed, and security proof of the improved scheme under elliptic curve factorization problem (ECFP) assumption and bilinear computational diffie-hellman problem (BCDH) assumption is also proposed.

  20. Sommerfeld Enhancement from Multiple Mediators

    OpenAIRE

    McDonald, Kristian L.

    2012-01-01

    We study the Sommerfeld enhancement experienced by a scattering object that couples to a tower of mediators. This can occur in, e.g., models of secluded dark matter when the mediator scale is generated naturally by hidden-sector confinement. Specializing to the case of a confining CFT, we show that off-resonant values of the enhancement can be increased by ~ 20% for cases of interest when (i) the (strongly-coupled) CFT admits a weakly-coupled dual description and (ii) the conformal symmetry h...

  1. Dynamical Messengers for Gauge Mediation

    Energy Technology Data Exchange (ETDEWEB)

    Hook, Anson; Torroba, Gonzalo; /SLAC /Stanford U., Phys. Dept.

    2011-08-17

    We construct models of indirect gauge mediation where the dynamics responsible for breaking supersymmetry simultaneously generates a weakly coupled subsector of messengers. This provides a microscopic realization of messenger gauge mediation where the messenger and hidden sector fields are unified into a single sector. The UV theory is SQCD with massless and massive quarks plus singlets, and at low energies it flows to a weakly coupled quiver gauge theory. One node provides the primary source of supersymmetry breaking, which is then transmitted to the node giving rise to the messenger fields. These models break R-symmetry spontaneously, produce realistic gaugino and sfermion masses, and give a heavy gravitino.

  2. Anomaly mediation in superstring theory

    International Nuclear Information System (INIS)

    We study anomaly mediated supersymmetry breaking in type IIB string theory and use our results to test the supergravity formula for anomaly mediated gaugino masses. We compute 1-loop gaugino masses for models of D3-branes on orbifold singularities with 3-form fluxes by calculating the annulus correlator of 3-form flux and two gauginos in the zero momentum limit. Consistent with supergravity expectations we find both anomalous and running contributions to 1-loop gaugino masses. For background Neveu-Schwarz H-flux we find an exact match with the supergravity formula. For Ramond-Ramond flux there is an off-shell ambiguity that precludes a full matching. The anomaly mediated gaugino masses, while determined by the infrared spectrum, arise from an explicit sum over UV open string winding modes. We also calculate brane-to-brane tree-level gravity mediated gaugino masses and show that there are two contributions coming from the dilaton and from the twisted modes, which are suppressed by the full T6 volume and the untwisted T2 volume respectively. (orig.)

  3. Mediated Encryption: Analysis and Design

    Directory of Open Access Journals (Sweden)

    I. Elashry1

    2015-01-01

    Full Text Available Boneh, Ding and Tsudik presented identity-based mediated RSA encryption and signature systems in which the users are not allowed to decrypt/sign messages without the authorisation of a security mediator.We show that ID-MRSA is not secure and we present a secure modified version of it which is as efficient as the original system. We also propose a generic mediated encryption that translates any identity based encryption to a mediated version of this IBE. It envelops an IBE encrypted message using a user’s identity into an IBE envelope using the identity of the SEM. We present two security models based on the role of the adversary whether it is a revoked user or a hacked SEM. We prove that GME is as secure as the SEM’s IBE against a revoked user and as secure as the user’s IBE against a hacked SEM. We also present two implementations of GME based on Boneh-Franklin FullIBE system which is a pairing-based system and Boneh, Gentry and Hamburg (BGH system which is pairing-free system.

  4. Anomaly mediation in superstring theory

    Energy Technology Data Exchange (ETDEWEB)

    Conlon, Joseph P. [Rudolf Peierls Center for Theoretical Physics, Oxford (United Kingdom); Balliol College, Oxford (United Kingdom); Goodsell, Mark [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Palti, Eran [Centre de Physique Theoretique, Ecole Polytechnique, CNRS, Palaiseau (France)

    2010-08-15

    We study anomaly mediated supersymmetry breaking in type IIB string theory and use our results to test the supergravity formula for anomaly mediated gaugino masses. We compute 1-loop gaugino masses for models of D3-branes on orbifold singularities with 3-form fluxes by calculating the annulus correlator of 3-form flux and two gauginos in the zero momentum limit. Consistent with supergravity expectations we find both anomalous and running contributions to 1-loop gaugino masses. For background Neveu-Schwarz H-flux we find an exact match with the supergravity formula. For Ramond-Ramond flux there is an off-shell ambiguity that precludes a full matching. The anomaly mediated gaugino masses, while determined by the infrared spectrum, arise from an explicit sum over UV open string winding modes. We also calculate brane-to-brane tree-level gravity mediated gaugino masses and show that there are two contributions coming from the dilaton and from the twisted modes, which are suppressed by the full T{sup 6} volume and the untwisted T{sup 2} volume respectively. (orig.)

  5. Eicosanoids mediate insect hemocyte migration

    Science.gov (United States)

    Hemocyte chemotaxis toward infection and wound sites is an essential component of insect defense reactions, although the biochemical signal mechanisms responsible for mediating chemotaxis in insect cells are not well understood. Here we report on the outcomes of experiments designed to test the hyp...

  6. Should Lawyers Act as Mediators?

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    On September 1, the Henan Provincial Department of Justice and the Henan Higher People’s Court jointly issued a document. It suggests lawyers do as much as possible to mediate between litigants involved in lawsuits of civil disputes and misdemeanor lawsuits, in order to help them

  7. BOEM Wind Planning Areas

    Data.gov (United States)

    Bureau of Ocean Energy Management, Department of the Interior — This data set represents the most recent changes for the Wind Development Planning Areas in the Atlantic. Wind Planning Areas in this dataset represent up to six...

  8. LeaseAreas

    Data.gov (United States)

    Bureau of Ocean Energy Management, Department of the Interior — Federal outer Continental Shelf (OCS) Sand and Gravel Borrow Areas (Lease Areas) are polygons which are maintained by the Bureau of Ocean Energy Management (BOEM),...

  9. Selected areas in cryptography

    CERN Document Server

    Oorschot, Paul

    1997-01-01

    Selected Areas in Cryptography brings together in one place important contributions and up-to-date research results in this fast moving area. Selected Areas in Cryptography serves as an excellent reference, providing insight into some of the most challenging research issues in the field.

  10. Developing Illustrative Descriptors of Aspects of Mediation for the Common European Framework of Reference (CEFR): A Council of Europe Project

    Science.gov (United States)

    North, Brian; Piccardo, Enrica

    2016-01-01

    The notion of mediation has been the object of growing interest in second language education in recent years. The increasing awareness of the complex nature of the process of learning--and teaching--stretches our collective reflection towards less explored areas. In mediation, the immediate focus is on the role of language in processes like…

  11. Women's Facial Redness Increases Their Perceived Attractiveness: Mediation Through Perceived Healthiness.

    Science.gov (United States)

    Pazda, Adam D; Thorstenson, Christopher A; Elliot, Andrew J; Perrett, David I

    2016-07-01

    In the present research, we investigated whether the red-attraction relation that has been observed for men viewing women may also be observed with regard to women's facial redness. We manipulated facial redness by slightly increasing or decreasing the redness on the faces of baseline pictures of target women, and then had men judge the attractiveness of the women. We also examined healthiness perceptions as a mediator of the redness-attraction relation, along with several other candidate mediator variables. A series of experiments showed that increased redness led to increased ratings of attractiveness, and decreased redness led to decreased ratings of attractiveness. Perceived healthiness was documented as a mediator of the influence of female facial redness on male perceptions of attractiveness, and this mediation was independent of other candidate mediator variables. The findings highlight the importance of attending to facial coloration as an attraction-relevant cue and point to interesting areas for subsequent research. PMID:26908567

  12. Platelets stimulate fibroblast-mediated contraction of collagen gels

    Directory of Open Access Journals (Sweden)

    Lundahl Joachim

    2003-10-01

    Full Text Available Abstract Background Platelets are thought to play a role in a variety of inflammatory conditions in the lung, some of which may lead to fibrosis. In the current study we tested the hypothesis that whole platelets and platelet lysate can mediate remodelling of extracellular matrix in vitro by affecting fibroblast-mediated contraction of a collagen gel. We also sought to determine to what extent platelet-derived growth factor (PDGF and transforming growth factor-β (TGF-β contribute to this effect. Methods Washed platelets, isolated from healthy blood donors, and platelet lysate (freezing and thawing, were cast together with human lung fibroblasts in three-dimensional collagen gels. The gels were then released and cultured for four days. PDGF and TGF-β1 concentrations were measured in culture supernatants by ELISA. Results Both platelets and platelet lysate augmented fibroblast-mediated gel contraction in a time and concentration dependent manner (19.9% ± 0.1 (mean ± SEM of initial area vs. 48.0% ± 0.4 at 48 hours; P 1 and PDGF-AA/AB were released in co-culture. PDGF-AA/AB had a maximum release at 24 hours whereas TGF-β1 release increased with longer culture periods. Neutralising antibodies to these mediators partially inhibited platelet-induced gel contraction. Conclusion We conclude that platelets may promote remodelling of extracellular matrix in vitro and that PDGF and TGF-β partially mediate this effect, also indicating a role for other mediators. The findings may be an important mechanism in regulating repair processes after injury.

  13. Aspects of non-minimal gauge mediation

    OpenAIRE

    Shirai, Satoshi; Yamazaki, Masahito; Yonekura, Kazuya

    2010-01-01

    A large class of non-minimal gauge mediation models, such as (semi-)direct gauge mediation, predict a hierarchy between the masses of the supersymmetric standard model gauginos and those of scalar particles. We perform a comprehensive study of these non-minimal gauge mediation models, including mass calculations in semi-direct gauge mediation, to illustrate these features, and discuss the phenomenology of the models. We point out that the cosmological gravitino problem places stringent constr...

  14. Mediation Analysis in Psychosomatic Medicine Research

    OpenAIRE

    Lockhart, Ginger; MacKinnon, David P.; Ohlrich, Vanessa

    2010-01-01

    This article presents an overview of statistical mediation analysis and its application to psychosomatic medicine research. The article begins with a description of the major approaches to mediation analysis and an evaluation of the strengths and limits of each. Emphasis is placed on longitudinal mediation models, and an application using latent growth modeling is presented. The article concludes with a description of recent developments in mediation analysis and suggestions for the use of me...

  15. Neural circuits mediating olfactory-driven behavior in fish

    Directory of Open Access Journals (Sweden)

    Florence eKermen

    2013-04-01

    Full Text Available The fish olfactory system processes odor signals and mediates behaviors that are crucial for survival such as foraging, courtship and alarm response. Although the upstream olfactory brain areas (olfactory epithelium and olfactory bulb are well studied, less is known about their target brain areas and the role they play in generating odor-driven behaviors. Here we review a broad range of literature on the anatomy, physiology and behavioral output of the olfactory system and its target areas in a wide range of teleost fish. Additionally, we discuss how applying recent technological advancements to the zebrafish (Danio rerio could help in understanding the function of these target areas. We hope to provide a framework for elucidating the neural circuit computations underlying the odor-driven behaviors in this small, transparent and genetically amenable vertebrate.

  16. 34 CFR 303.419 - Mediation.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Mediation. 303.419 Section 303.419 Education... DISABILITIES Procedural Safeguards Mediation and Due Process Procedures for Parents and Children § 303.419 Mediation. (a) General. Each State shall ensure that procedures are established and implemented to...

  17. Single-Level and Multilevel Mediation Analysis

    Science.gov (United States)

    Tofighi, Davood; Thoemmes, Felix

    2014-01-01

    Mediation analysis is a statistical approach used to examine how the effect of an independent variable on an outcome is transmitted through an intervening variable (mediator). In this article, we provide a gentle introduction to single-level and multilevel mediation analyses. Using single-level data, we demonstrate an application of structural…

  18. 34 CFR 300.506 - Mediation.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Mediation. 300.506 Section 300.506 Education... DISABILITIES Procedural Safeguards Due Process Procedures for Parents and Children § 300.506 Mediation. (a... due process complaint, to resolve disputes through a mediation process. (b) Requirements....

  19. 13 CFR 117.12 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Mediation. 117.12 Section 117.12... Mediation. (a) SBA shall, after ensuring that the complaint falls within the coverage of this Act and all... clearly within an exception, promptly refer the complaint to the Federal Mediation and...

  20. 7 CFR 900.109 - Mediation agreement.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Mediation agreement. 900.109 Section 900.109 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... Mediation agreement. An agreement arrived at by mediation shall not become effective until approved by...

  1. Methods for Mediation Analysis with Missing Data

    Science.gov (United States)

    Zhang, Zhiyong; Wang, Lijuan

    2013-01-01

    Despite wide applications of both mediation models and missing data techniques, formal discussion of mediation analysis with missing data is still rare. We introduce and compare four approaches to dealing with missing data in mediation analysis including list wise deletion, pairwise deletion, multiple imputation (MI), and a two-stage maximum…

  2. 7 CFR 400.94 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Mediation. 400.94 Section 400.94 Agriculture... AGRICULTURE GENERAL ADMINISTRATIVE REGULATIONS Appeal Procedure § 400.94 Mediation. For adverse decisions only: (a) Appellants have the right to seek mediation or other forms of alternative dispute resolution...

  3. 41 CFR 101-8.717 - Mediation.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Mediation. 101-8.717... FINANCIAL ASSISTANCE 8.7-Discrimination Prohibited on the Basis of Age § 101-8.717 Mediation. (a) GSA promptly refers to the mediation agency designated by the Secretary, HHS, all sufficient complaints...

  4. 45 CFR 617.10 - Mediation.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Mediation. 617.10 Section 617.10 Public Welfare... OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM NSF § 617.10 Mediation. (a) NSF will refer to the Federal Mediation and Conciliation Service all complaints that fall...

  5. On the Spectrum of Direct Gaugino Mediation

    OpenAIRE

    Auzzi, Roberto; Giveon, Amit; Gudnason, Sven Bjarke; Shacham, Tomer

    2011-01-01

    In direct gauge mediation, the gaugino masses are anomalously small, giving rise to a split SUSY spectrum. Here we investigate the superpartner spectrum in a minimal version of "direct gaugino mediation." We find that the sfermion masses are comparable to those of the gauginos - even in the hybrid gaugino-gauge mediation regime - if the messenger scale is sufficiently small.

  6. Mediational Competencies for Online Education

    Directory of Open Access Journals (Sweden)

    María Elena Chan Núñez

    2005-11-01

    Full Text Available Addressed in the article is a position taken within and in favor of education and virtuality, considering the importance of training constructors of the digital environment. The competencies needed by actors of educational processes, the same which are necessary for their construction, are conceptualized as mediational. Because these are not usually the competencies most visibly when teachers and students are trained for online education, we found it of interest to present part of a research project on this type of competencies. The work starts out from an axiological position on virtual education, the recognition of the way the technologies model educational interactions on line. It follows with the notion of mediation and meditational competency, and comes to a design model that would consider these competencies in the development of learning environments. The article closes with reflections about the interdisciplinary integration necessary for a technological and educational development based on a communicative paradigm.

  7. Vernalization-mediated chromatin changes.

    Science.gov (United States)

    Zografos, Brett R; Sung, Sibum

    2012-07-01

    Proper flowering time is vital for reproductive fitness in flowering plants. In Arabidopsis, vernalization is mediated primarily through the repression of a MADS box transcription factor, FLOWERING LOCUS C (FLC). The induction of a plant homeodomain-containing protein, VERNALIZATION INSENSITIVE 3 (VIN3), by vernalizing cold is required for proper repression of FLC. One of a myriad of changes that occurs after VIN3 is induced is the establishment of FLC chromatin at a mitotically repressed state due to the enrichment of repressive histone modifications. VIN3 induction by cold is the earliest known event during the vernalization response and includes changes in histone modifications at its chromatin. Here, the current understanding of the vernalization-mediated chromatin changes in Arabidopsis is discussed, with a focus on the roles of shared chromatin-modifying machineries in regulating VIN3 and FLC gene family expression during the course of vernalization.

  8. Sequestered gravity in gauge mediation

    Science.gov (United States)

    Antoniadis, Ignatios; Benakli, Karim; Quiros, Mariano

    2016-07-01

    We present a novel mechanism of supersymmetry breaking embeddable in string theory and simultaneously sharing the main advantages of (sequestered) gravity and gauge mediation. It is driven by a Scherk-Schwarz deformation along a compact extra dimension, transverse to a brane stack supporting the supersymmetric extension of the Standard Model. This fixes the magnitude of the gravitino mass, together with that of the gauginos of a bulk gauge group, at a scale as high as 10^{10} GeV. Supersymmetry breaking is mediated to the observable sector dominantly by gauge interactions using massive messengers transforming non-trivially under the bulk and Standard Model gauge groups and leading to a neutralino LSP as dark matter candidate. The Higgsino mass μ and soft Higgs-bilinear B_μ term could be generated at the same order of magnitude as the other soft terms by effective supergravity couplings as in the Giudice-Masiero mechanism.

  9. The communicative figurations of mediatized worlds: mediatization research in times of the “mediation of everything”

    Directory of Open Access Journals (Sweden)

    Andreas Hepp

    2014-06-01

    Full Text Available When various media in their entirety mark how we articulate our social worlds, we need an approach of mediatization research that reflects this transmediality. To develop such an approach, the article discusses the institutionalist and social-constructivist traditions of mediatization research. Both concur that mediatization is a concept to capture the interrelation between the change of media and communication, and the change of culture and society. Such a conceptual reflection offers the chance to view the mediatization as the change of transmedial communicative figurations. Based on this theoretical foundation, the article reflects a twofold operationalization, i.e. as diachronous and synchronous mediatization research.

  10. Palladium-mediated intracellular chemistry

    OpenAIRE

    Rahimi M. Yusop; Unciti-Broceta, Asier; Johansson, Emma M. V.; Rosario M. Sanchez-Martin; Bradley, Mark

    2011-01-01

    Many important intracellular biochemical reactions are modulated by transition metals, typically in the form of metalloproteins. The ability to carry out selective transformations inside a cell would allow researchers to manipulate or interrogate innumerable biological processes. Here, we show that palladium nanoparticles trapped within polystyrene microspheres can enter cells and mediate a variety of Pd-0-catalysed reactions, such as allylcarbamate cleavage and Suzuki-Miyaura cross-coupling....

  11. Notch-Mediated Cell Adhesion

    OpenAIRE

    Akihiko Murata; Shin-Ichi Hayashi

    2016-01-01

    Notch family members are generally recognized as signaling molecules that control various cellular responses in metazoan organisms. Early fly studies and our mammalian studies demonstrated that Notch family members are also cell adhesion molecules; however, information on the physiological roles of this function and its origin is limited. In this review, we discuss the potential present and ancestral roles of Notch-mediated cell adhesion in order to explore its origin and the initial roles of...

  12. Direct mediation, duality and unification

    International Nuclear Information System (INIS)

    It is well-known that in scenarios with direct gauge mediation of supersymmetry breaking the messenger fields significantly affect the running of Standard Model couplings and introduce Landau poles which are difficult to avoid. Among other things, this appears to remove any possibility of a meaningful unification prediction and is often viewed as a strong argument against direct mediation. We propose two ways that Seiberg duality can circumvent this problem. In the first, which we call 'deflected-unification', the SUSY-breaking hidden sector is a magnetic theory which undergoes a Seiberg duality to an electric phase. Importantly, the electric version has fewer fundamental degrees of freedom coupled to the MSSM compared to the magnetic formulation. This changes the β-functions of the MSSM gauge couplings so as to push their Landau poles above the unification scale. We show that this scenario is realised for recently suggested models of gauge mediation based on a metastable SCQD-type hidden sector directly coupled to MSSM. The second possibility for avoiding Landau poles, which we call 'dual-unification', begins with the observation that, if the mediating fields fall into complete SU(5) multiplets, then the MSSM+messengers exhibits a fake unification at unphysical values of the gauge couplings. We show that, in known examples of electric/magnetic duals, such a fake unification in the magnetic theory reflects a real unification in the electric theory. We therefore propose that the Standard Model could itself be a magnetic dual of some unknown electric theory in which the true unification takes place. This scenario maintains the unification prediction (and unification scale) even in the presence of Landau poles in the magnetic theory below the GUT scale. We further note that this dual realization of grand unification can explain why Nature appears to unify, but the proton does not decay.

  13. CELLULAR INTERACTIONS MEDIATED BY GLYCONECTIDS

    OpenAIRE

    Popescu, O.; Sumanovski, L. T.; I. Checiu; Elisabeta Popescu; G. N. Misevic

    1999-01-01

    Cellular interactions involve many types of cell surface molecules and operate via homophilic and/or heterophilic protein-protein and protein-carbohydrate binding. Our investigations in different model-systems (marine invertebrates and mammals) have provided direct evidence that a novel class of primordial proteoglycans, named by us gliconectins, can mediate cell adhesion via a new alternative molecular mechanism of polyvalent carbohydrate-carbohydrate binding. Biochemical characterization of...

  14. Investigation of SNARE-Mediated Membrane Fusion Mechanism Using Atomic Force Microscopy

    OpenAIRE

    Abdulreda, Midhat H.; Moy, Vincent T.

    2009-01-01

    Membrane fusion is driven by specialized proteins that reduce the free energy penalty for the fusion process. In neurons and secretory cells, soluble N-ethylmaleimide-sensitive factor-attachment protein (SNAP) receptors (SNAREs) mediate vesicle fusion with the plasma membrane during vesicular content release. Although, SNAREs have been widely accepted as the minimal machinery for membrane fusion, the specific mechanism for SNARE-mediated membrane fusion remains an active area of research. Her...

  15. Substrate mediated enzyme prodrug therapy.

    Directory of Open Access Journals (Sweden)

    Betina Fejerskov

    Full Text Available In this report, we detail Substrate Mediated Enzyme Prodrug Therapy (SMEPT as a novel approach in drug delivery which relies on enzyme-functionalized cell culture substrates to achieve a localized conversion of benign prodrug(s into active therapeutics with subsequent delivery to adhering cells or adjacent tissues. For proof-of-concept SMEPT, we use surface adhered micro-structured physical hydrogels based on poly(vinyl alcohol, β-glucuronidase enzyme and glucuronide prodrugs. We demonstrate enzymatic activity mediated by the assembled hydrogel samples and illustrate arms of control over rate of release of model fluorescent cargo. SMEPT was not impaired by adhering cells and afforded facile time - and dose - dependent uptake of the in situ generated fluorescent cargo by hepatic cells, HepG2. With the use of a glucuronide derivative of an anticancer drug, SN-38, SMEPT afforded a decrease in cell viability to a level similar to that achieved using parent drug. Finally, dose response was achieved using SMEPT and administration of judiciously chosen concentration of SN-38 glucuronide prodrug thus revealing external control over drug delivery using drug eluting surface. We believe that this highly adaptable concept will find use in diverse biomedical applications, specifically surface mediated drug delivery and tissue engineering.

  16. Mediation, Mandatory Information and Facultative Applicability

    Directory of Open Access Journals (Sweden)

    Mihail-Silviu Pocora

    2014-05-01

    Full Text Available Considering that mediation is a facilitating way to access the alternative solving of litigations in conciliatory terms, the study is encouraging using the mediation and providing a balanced relationship between mediation and judiciary procedures. As an aftermath of summary definition, we can say that role of mediation is to overcome the communicative barriers in order to solve the conflict and save the fact situation on both parts. The study aims to analyze objectively all consequences of both solving ways of litigations: traditional one, through the law court and mediation, with the advantages derived from them (celerity vs. time consuming, expensive judiciary proceedings vs. low costs, etc.

  17. Protected areas and poverty

    OpenAIRE

    Brockington, Daniel; Wilkie, David

    2015-01-01

    Protected areas are controversial because they are so important for conservation and because they distribute fortune and misfortune unevenly. The nature of that distribution, as well as the terrain of protected areas themselves, have been vigorously contested. In particular, the relationship between protected areas and poverty is a long-running debate in academic and policy circles. We review the origins of this debate and chart its key moments. We then outline the continuing flashpoints and ...

  18. CVP Service Area

    Data.gov (United States)

    California Department of Resources — Federal Water Contract Service Area boundaries are incorporated boundaries of districts having contracts with the U.S. Bureau of Reclamation (Reclamation), within...

  19. Construction mediation as a developmental process

    Directory of Open Access Journals (Sweden)

    Julian Sidoli del Ceno

    2013-02-01

    Full Text Available This paper seeks to argue that mediation has been hitherto conceived in the construction industry, and indeed by practitioners in other related disciplines such as property management, as largely a ‘problem-solving’ mechanism. Whilst this is clearly an aim of mediation there is also the appended danger that the value of mediation is conceived in these terms alone. If this is the case, then its value, or success, is conceived very narrowly. The aim of this paper is, then, to argue that there are wider values to mediation in a construction setting. These values can be considered as a ‘family’ of related attitudes, skills and perceptions that can positively affect the persons involved. By affecting growth in individuals an organisational change may follow. This, in turn, can result in a significant cultural change in the industry, and associated professions as a whole, as well as having a positive impact on construction education. The paper begins by an overview of the development of mediation and proceeds to consider its current use of mediation in construction. It then considers the question of how mediation success is conceived. The paper argues that both the current practice of construction mediation and the way in which its success is measured are too narrow. It argues that a wider approach to construction mediation is required. Finally, drawing from the literature on ‘idealist’ mediation an account of mediation as a developmental process is developed.

  20. Instilling a mediation-based conflict resolution culture.

    Science.gov (United States)

    Miller, M; Wax, D

    1999-01-01

    Conflict thrives and grows in the increasingly competitive and uncertain health care environment. Conflict impacts health care organizations' performance in several areas: (1) patient grievances and health plan member disputes; (2) internal employee and management disputes; and (3) payer, provider, and vendor disputes. "Grief Budgets," the hard costs and soft costs due to disputes that are poorly handled and conflicts that are ignored, detract from an organizations health mission and erode its bottom line. This article offers a strategy to solve conflict at an early stage in all three areas, with measurable results that strengthen profits and improve customer service by instilling a mediation-based conflict resolution culture throughout the organization. Mediation is non-adversarial, neutral, proactive, and collaborative. It is also confidential and always protects the future relationship between the parties. The challenge, therefore, is to strategically implant mediation into the health care organization's structure, to intercept and solve conflict early on. The article provides an overview of the steps needed to install a dispute resolution program. PMID:10557485

  1. Comprehensive area assessment consultation

    OpenAIRE

    Sustainable Development Commission

    2008-01-01

    The proposals for the new comprehensive area assessment are a very positive step forward for sustainable development compared to previous local performance assessment frameworks, but will need further strengthening if they are to help support the Government's aim of putting sustainable development at the heart of sustainable community strategies and their delivery mechanism, local area agreements. Publisher PDF

  2. Available area isotherm

    NARCIS (Netherlands)

    Bosma, JC; Wesselingh, JA

    2004-01-01

    A new isotherm is presented for adsorption of proteins, the available area isotherm. This isotherm has a steric basis, unlike the (steric) mass action model. The shape of the available area isotherm is determined only by geometric exclusion. With the new isotherm, experimental results can be fitted

  3. Mediation et violences conjugales Mediation and Domestic Violence

    Directory of Open Access Journals (Sweden)

    Jacques Faget

    2009-11-01

    Full Text Available Ce travail analyse  les potentialités et les limites du recours à la médiation en matière de régulation des violences conjugales.S’appuyant sur une étude empirique de sa mise en œuvre en France et sur la littérature scientifique existante il révèle l’existence de deux modèles de pratique reflétant deux conceptions de la médiation et plus généralement de l’articulation entre régulations pénales et sociales.This paper analyzes the potential and limits of recourse to mediation for regulating domestic violence. On the basis of an empirical study of its implementation in France and of the existing academic literature, it shows the existence of two types of practices reflecting two conceptions of mediation and more generally, two conceptions of the articulation between social and penal regulation. Full Text

  4. PYRAMID ROADLESS AREA, CALIFORNIA.

    Science.gov (United States)

    Armstrong, Augustus K.; Scott, Douglas F.

    1984-01-01

    A geologic and mineral survey was conducted in the Pyramid Roadless Area, California. The area contains mineral showings, but no mineral-resource potential was identified during our studies. Three granodiorite samples on the west side of the roadless area contained weakly anomalous concentrations of uranium. Two samples of roof-pendant rocks, one metasedimentary rock and one metavolcanic rock, contain low concentrations of copper, and of copper and molybdenum, respectively. Although none was identified, the geologic terrane is permissive for mineral occurrences and large-scale, detailed geologic mapping of the areas of metasedimentary and metavolcanic roof pendants in the Pyramid Roadless Area could define a mineral-resource potential for tungsten and precious metals.

  5. Mediated electrochemical hazardous waste destruction

    International Nuclear Information System (INIS)

    There are few permitted processes for mixed waste (radioactive plus chemically hazardous) treatment. We are developing an electrochemical process, based upon mediated electrochemical oxidation (MEO), that converts toxic organic components of mixed waste to water, carbon dioxide, and chloride or chloride precipitates. Aggressive oxidizer ions such as Ag2+, Co3+, or Fe3+ are produced at an anode. These can attack organic molecules directly, and may also produce hydroxyl free radicals that promote destruction. Solid and liquid radioactive waste streams containing only inorganic radionuclide forms may be treated with existing technology and prepared for final disposal. The coulombic efficiency of the process has been determined, as well as the destruction efficiency for ethylene glycol, a surrogate waste. In addition, hazardous organic materials are becoming very expensive to dispose of and when they are combined with transuranic radioactive elements no processes are presently permitted. Mediated electrochemical oxidation is an ambient- temperature aqueous-phase process that can be used to oxidize organic components of mixed wastes. Problems associated with incineration, such as high-temperature volatilization of radionuclides, are avoided. Historically, Ag(II) has been used as a mediator in this process. Fe(III) and Co(III) are attractive alternatives to Ag(II) since they form soluble chlorides during the destruction of chlorinated solvents. Furthermore, silver itself is toxic heavy metal. Quantitative data have been obtained for the complete oxidation of ethylene glycol by Fe(III) and Co(III). Though ethylene glycol is a nonhalogenated organic, these data have enabled us to make direct comparisons of activities of Fe(III) and Co(III) with Ag(II). Very good quantitative data for the oxidation of ethylene glycol by Ag(II) had already been collected

  6. Hydrological models are mediating models

    Science.gov (United States)

    Babel, L. V.; Karssenberg, D.

    2013-08-01

    Despite the increasing role of models in hydrological research and decision-making processes, only few accounts of the nature and function of models exist in hydrology. Earlier considerations have traditionally been conducted while making a clear distinction between physically-based and conceptual models. A new philosophical account, primarily based on the fields of physics and economics, transcends classes of models and scientific disciplines by considering models as "mediators" between theory and observations. The core of this approach lies in identifying models as (1) being only partially dependent on theory and observations, (2) integrating non-deductive elements in their construction, and (3) carrying the role of instruments of scientific enquiry about both theory and the world. The applicability of this approach to hydrology is evaluated in the present article. Three widely used hydrological models, each showing a different degree of apparent physicality, are confronted to the main characteristics of the "mediating models" concept. We argue that irrespective of their kind, hydrological models depend on both theory and observations, rather than merely on one of these two domains. Their construction is additionally involving a large number of miscellaneous, external ingredients, such as past experiences, model objectives, knowledge and preferences of the modeller, as well as hardware and software resources. We show that hydrological models convey the role of instruments in scientific practice by mediating between theory and the world. It results from these considerations that the traditional distinction between physically-based and conceptual models is necessarily too simplistic and refers at best to the stage at which theory and observations are steering model construction. The large variety of ingredients involved in model construction would deserve closer attention, for being rarely explicitly presented in peer-reviewed literature. We believe that devoting

  7. The evolution of inflammatory mediators

    Directory of Open Access Journals (Sweden)

    Andrew F. Rowley

    1996-01-01

    Full Text Available Invertebrates do not display the level of sophistication in immune reactivity characteristic of mammals and other ‘higher’ vertebrates. Their great number and diversity of forms, however, reflect their evolutionary success and hence they must have effective mechanisms of defence to deal with parasites and pathogens and altered self tissues. Inflammation appears to be an important first line defence in all invertebrates and vertebrates. This brief review deals with the inflammatory responses of invertebrates and fish concentrating on the cell types involved and the mediators of inflammation, in particular, eicosanoids, cytokines and adhesion molecules.

  8. Universality in pure gravity mediation

    International Nuclear Information System (INIS)

    If low-energy supersymmetry is realized in nature, the apparent discovery of a Higgs boson with mass around 125 GeV suggests a supersymmetric mass spectrum in the TeV or multi-TeV range. Multi-TeV scalar masses are a necessary component of supersymmetric models with pure gravity mediation or in any model with strong moduli stabilization. Here, we show that full scalar mass universality remains viable as long as the ratio of Higgs vevs, tanβ, is relatively small (< or similar 2.5). We discuss in detail the low-energy (observable) consequences of these models. (orig.)

  9. Membrane tension and peripheral protein density mediate membrane shape transitions

    Science.gov (United States)

    Shi, Zheng; Baumgart, Tobias

    2015-01-01

    Endocytosis is a ubiquitous eukaryotic membrane budding, vesiculation and internalization process fulfilling numerous roles including compensation of membrane area increase after bursts of exocytosis. The mechanism of the coupling between these two processes to enable homeostasis is not well understood. Recently, an ultrafast endocytosis (UFE) pathway was revealed with a speed significantly exceeding classical clathrin-mediated endocytosis (CME). Membrane tension reduction is a potential mechanism by which endocytosis can be rapidly activated at remote sites. Here, we provide experimental evidence for a mechanism whereby membrane tension reduction initiates membrane budding and tubulation mediated by endocytic proteins, such as endophilin A1. We find that shape instabilities occur at well-defined membrane tensions and surface densities of endophilin. From our data, we obtain a membrane shape stability diagram that shows remarkable consistency with a quantitative model. This model applies to all laterally diffusive curvature-coupling proteins and therefore a wide range of endocytic proteins.

  10. Socialising Semiotic Mediation: Some Reflections on Rosa and Pievi's Paper

    DEFF Research Database (Denmark)

    Glaveanu, Vlad Petre

    2013-01-01

    This article aims to reflect on the relation between social representations theory (SRT) and a cultural psychological view of semiotics, as presented in Rosa and Pievi's paper (this issue). It is argued that a fruitful dialogue can be established between the two orientations, one that draws...... on similarities but also addresses and exploits several important conceptual differences. The article proceeds by outlining the areas in which SRT can be enriched by a semiotic account – such as incorporating a more clearly articulated theory of signs and unpacking further the role of mediated action and personal...... experience – as well as the ways in which the latter can benefit from engaging with the notion of social representations. Most of all, I propose that what a SRT-informed view of cultural psychology can offer us is a ‘socialized model of semiotic mediation', one that grounds the construction of knowledge...

  11. Protected areas and poverty

    Science.gov (United States)

    Brockington, Daniel; Wilkie, David

    2015-01-01

    Protected areas are controversial because they are so important for conservation and because they distribute fortune and misfortune unevenly. The nature of that distribution, as well as the terrain of protected areas themselves, have been vigorously contested. In particular, the relationship between protected areas and poverty is a long-running debate in academic and policy circles. We review the origins of this debate and chart its key moments. We then outline the continuing flashpoints and ways in which further evaluation studies could improve the evidence base for policy-making and conservation practice. PMID:26460124

  12. Transporter-mediated biofuel secretion.

    Science.gov (United States)

    Doshi, Rupak; Nguyen, Tuan; Chang, Geoffrey

    2013-05-01

    Engineering microorganisms to produce biofuels is currently among the most promising strategies in renewable energy. However, harvesting these organisms for extracting biofuels is energy- and cost-intensive, limiting the commercial feasibility of large-scale production. Here, we demonstrate the use of a class of transport proteins of pharmacological interest to circumvent the need to harvest biomass during biofuel production. We show that membrane-embedded transporters, better known to efflux lipids and drugs, can be used to mediate the secretion of intracellularly synthesized model isoprenoid biofuel compounds to the extracellular milieu. Transporter-mediated biofuel secretion sustainably maintained an approximate three- to fivefold boost in biofuel production in our Escherichia coli test system. Because the transporters used in this study belong to the ubiquitous ATP-binding cassette protein family, we propose their use as "plug-and-play" biofuel-secreting systems in a variety of bacteria, cyanobacteria, diatoms, yeast, and algae used for biofuel production. This investigation showcases the potential of expressing desired membrane transport proteins in cell factories to achieve the export or import of substances of economic, environmental, or therapeutic importance.

  13. Strictly Anomaly Mediated Supersymmetry Breaking

    CERN Document Server

    Hindmarsh, Mark

    2012-01-01

    We consider an MSSM extension with anomaly mediation as the source of supersymmetry-breaking, and a U(1) symmetry which solves the tachyonic slepton problem, and introduces both the see-saw mechanism for neutrino masses, and the Higgs mu-term. We compare its spectra with those from so-called minimal anomaly mediated supersymmetry breaking. We find a Standard Model-like Higgs of mass 124 GeV with a gravitino mass of 120 TeV and tan(beta)=17, while a contribution to the muon anomalous magnetic moment within 2 sigma of the discrepancy between Standard Model theory and experiment favours a slightly lower gravitino mass of around 80 TeV. The model naturally produces a period of hybrid inflation, with exit to a false vacuum characterised by large Higgs vevs, the true ground state being achieved after a period of thermal inflation. The scalar spectral index is reduced to approximately 0.975, and the correct abundance of dark matter can be produced by decays of thermally-produced gravitinos, provided the gravitino ma...

  14. Neural networks mediating sentence reading in the deaf

    Science.gov (United States)

    Hirshorn, Elizabeth A.; Dye, Matthew W. G.; Hauser, Peter C.; Supalla, Ted R.; Bavelier, Daphne

    2014-01-01

    The present work addresses the neural bases of sentence reading in deaf populations. To better understand the relative role of deafness and spoken language knowledge in shaping the neural networks that mediate sentence reading, three populations with different degrees of English knowledge and depth of hearing loss were included—deaf signers, oral deaf and hearing individuals. The three groups were matched for reading comprehension and scanned while reading sentences. A similar neural network of left perisylvian areas was observed, supporting the view of a shared network of areas for reading despite differences in hearing and English knowledge. However, differences were observed, in particular in the auditory cortex, with deaf signers and oral deaf showing greatest bilateral superior temporal gyrus (STG) recruitment as compared to hearing individuals. Importantly, within deaf individuals, the same STG area in the left hemisphere showed greater recruitment as hearing loss increased. To further understand the functional role of such auditory cortex re-organization after deafness, connectivity analyses were performed from the STG regions identified above. Connectivity from the left STG toward areas typically associated with semantic processing (BA45 and thalami) was greater in deaf signers and in oral deaf as compared to hearing. In contrast, connectivity from left STG toward areas identified with speech-based processing was greater in hearing and in oral deaf as compared to deaf signers. These results support the growing literature indicating recruitment of auditory areas after congenital deafness for visually-mediated language functions, and establish that both auditory deprivation and language experience shape its functional reorganization. Implications for differential reliance on semantic vs. phonological pathways during reading in the three groups is discussed. PMID:24959127

  15. MicroRNA-mediated somatic cell reprogramming.

    Science.gov (United States)

    Kuo, Chih-Hao; Ying, Shao-Yao

    2013-02-01

    Since the first report of induced pluripotent stem cells (iPSCs) using somatic cell nuclear transfer (SCNT), much focus has been placed on iPSCs due to their great therapeutic potential for diseases such as abnormal development, degenerative disorders, and even cancers. Subsequently, Takahashi and Yamanaka took a novel approach by using four defined transcription factors to generate iPSCs in mice and human fibroblast cells. Scientists have since been trying to refine or develop better approaches to reprogramming, either by using different combinations of transcription factors or delivery methods. However, recent reports showed that the microRNA expression pattern plays a crucial role in somatic cell reprogramming and ectopic introduction of embryonic stem cell-specific microRNAs revert cells back to an ESC-like state, although, the exact mechanism underlying this effect remains unclear. This review describes recent work that has focused on microRNA-mediated approaches to somatic cell reprogramming as well as some of the pros and cons to these approaches and a possible mechanism of action. Based on the pivotal role of microRNAs in embryogenesis and somatic cell reprogramming, studies in this area must continue in order to gain a better understanding of the role of microRNAs in stem cells regulation and activity. PMID:22961769

  16. 'Reverse gear' cellular movement mediated by chemokines.

    Science.gov (United States)

    Zlatopolskiy, A; Laurence, J

    2001-08-01

    We sought to model the mechanism by which leucocytes may be actively repulsed by a beta-chemokine signal. This model is used to interpret an apparent paradox in chemokine biology, whereby high levels of a T-cell chemoattractant, stromal cell derived factor-1 (SDF-1), are present in bone marrow and thymic tissues despite a paucity of mature T lymphocytes in these areas. We postulate the differential involvement in cell migration of the two binding sites on SDF-1 for its sole receptor, CXCR4, depending on whether high or low concentrations of SDF-1 are encountered by the cell. Site choice would be mediated by divergent affinities of the two binding interactions. We also propose differential signalling following SDF-1/CXCR4 interactions on the plasma membrane versus ligand/receptor complexes in endocytic vesicles. Preliminary data showing divergent susceptibility to kinase inhibitors depending on whether a cell is attracted to or repulsed by SDF-1, are consistent with this model. In terms of physical movement toward or away from a chemokine gradient, we compare the cycling of surface receptors during migration to the caterpillar drive of a tractor, which can change direction simply by altering the direction of rotation of its threads. Finally, the potential clinical implications of concentration-dependent, chemokine-based cell attraction and repulsion are discussed. PMID:11488980

  17. Decontamination & decommissioning focus area

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    In January 1994, the US Department of Energy Office of Environmental Management (DOE EM) formally introduced its new approach to managing DOE`s environmental research and technology development activities. The goal of the new approach is to conduct research and development in critical areas of interest to DOE, utilizing the best talent in the Department and in the national science community. To facilitate this solutions-oriented approach, the Office of Science and Technology (EM-50, formerly the Office of Technology Development) formed five Focus AReas to stimulate the required basic research, development, and demonstration efforts to seek new, innovative cleanup methods. In February 1995, EM-50 selected the DOE Morgantown Energy Technology Center (METC) to lead implementation of one of these Focus Areas: the Decontamination and Decommissioning (D & D) Focus Area.

  18. 300 AREA URANIUM CONTAMINATION

    International Nuclear Information System (INIS)

    (smbullet) Uranium fuel production (smbullet) Test reactor and separations experiments (smbullet) Animal and radiobiology experiments conducted at the. 331 Laboratory Complex (smbullet) .Deactivation, decontamination, decommissioning,. and demolition of 300 Area facilities

  19. Driftless Area NWR ROCSTAR

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Resources of Concern Selection Tool for Americas Refuges (ROCSTAR) was developed to assist national wildlife refuges, waterfowl production areas, wetland...

  20. Pilot Boarding Areas

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Pilot boarding areas are locations at sea where pilots familiar with local waters board incoming vessels to navigate their passage to a destination port. Pilotage...

  1. ABACC's nuclear accounting area

    International Nuclear Information System (INIS)

    The functions and activities of the Brazilian-Argentine Agency for the Accounting and Control of Nuclear Materials (ABACC) accounting area is outlined together with a detailed description of the nuclear accounting system used by the bilateral organization

  2. Legal and Psychological Aspects of Mediation

    Directory of Open Access Journals (Sweden)

    Dobrokhotova E. N.

    2016-01-01

    Full Text Available The article focuses on gradual innovation of mediation into the practice of social conflict resolution in the light of legal and psychological means of mediation. While mediation is perceived as a conflictological concept and is more widely used in dispute settlement and resolution, a new interdisciplinary field of theoretical knowledge with its own conceptual framework as well as a new professional and practical field are beginning to form both in Russia and in other countries. As theoretical and practical aspects of innovation in mediation require consolidation not only for its national development but also for the guaranteed international cooperation, the article touches upon some of the particular theoretical issues of the topic in question: terminological consistency, consolidation of the system of mediation principles, the phenomenon of juridisation of mediation and its limits.

  3. USW area analogs

    OpenAIRE

    Everett, Keith R.

    2005-01-01

    The purpose of this project is to investigate the feasibility of and methodology for the development of a set of environmental analogs of operational Undersea Warfare (USW) areas within fleet training areas. It is primarily a discussion of the identification of parameters that characterize the tactical USW environment, prioritization of these parameters, identification of existing databases that contain these parameters and an outline of the processes required to extract the desired data fro...

  4. Drainage of radioactive areas

    International Nuclear Information System (INIS)

    This Code of Practice covers all the drainage systems which may occur in the radioactive classified area of an establishment, namely surface water, foul, process and radioactive drainage. It also deals with final discharge lines. The Code of Practice concentrates on those aspects of drainage which require particular attention because the systems are in or from radioactive areas and typical illustrations are given in appendices. The Code makes references to sources of information on conventional aspects of drainage design. (author)

  5. The Economics of First-Contract Mediation

    OpenAIRE

    Dobbelaere, Sabien; LUTTENS, Roland Iwan

    2013-01-01

    This paper provides an economic foundation for non-binding mediation to stimulate first collective bargaining agreements, as implemented in British Columbia since 1993. We show that the outcome of first-contract mediation is Pareto efficient and proves immune to the insider-outsider problem of underhiring. We also demonstrate that equilibrium wages and profits under mediation coincide with the Owen values of the corresponding cooperative game with the coalitional structure that follows from u...

  6. Resolvins and protectins: mediating solutions to inflammation

    OpenAIRE

    Kohli, Payal; Levy, Bruce D.

    2009-01-01

    Resolution of inflammation has historically been viewed as a passive process, occurring as a result of the withdrawal of pro-inflammatory signals, including lipid mediators such as leukotrienes and prostaglandins. Thus, most anti-inflammatory drugs have traditionally targeted primarily mediator pathways that are engaged at the onset of inflammation. Only recently has it been established that inflammation resolution is an active process with a distinct set of chemical mediators. Several clinic...

  7. Confounding in the Estimation of Mediation Effects

    OpenAIRE

    Li, Y.; Bienias, J.L.; Bennett, D. A.

    2007-01-01

    A mediation effect explains the relationship of a risk factor and an outcome through a mediator variable which is a step in their pathway. Under the assumption of no cycling in the causal relationship, we consider various situations in which a fourth variable may interfere the estimation of a mediation effect as a confounding factor. Our asymptotic results, which are supported by a Monte Carlo study, show that adjusting for confounding factors under certain conditions ...

  8. Sparticle masses in deflected mirage mediation

    International Nuclear Information System (INIS)

    We discuss the sparticle mass patterns that can be realized in deflected mirage mediation scenario of supersymmetry breaking, in which the moduli, anomaly, and gauge mediations all contribute to the MSSM soft parameters. Analytic expression of low energy soft parameters and also the sfermion mass sum rules are derived, which can be used to interpret the experimentally measured sparticle masses within the framework of the most general mixed moduli-gauge-anomaly mediation. Phenomenological aspects of some specific examples are also discussed.

  9. Mediatized Extreme Right Activism and Discourse

    DEFF Research Database (Denmark)

    Peters, Rikke Alberg

    2015-01-01

    activism. It is a good example of how new contentious action repertoires in which online and street activism intertwine have also spread to extreme right groups. Despite its neo-fascist and extreme right content the ‘Become Immortal’ campaign serves as an illustrative case for the study of mediated...... and mediatized activism. In order to analyse of the protest form, the visual aesthetics and the discourse of ‘The Immortals’, the paper mobilises two concepts from media and communication studies: mediation and mediatization. It will be argued that that the current transformation of the extreme right: that is...

  10. Focus point supersymmetry in extended gauge mediation

    International Nuclear Information System (INIS)

    We propose a small extension of the minimal gauge mediation through the combination of extended gauge mediation and conformal sequestering. We show that the focus point supersymmetry can be realized naturally, and the fine tuning is significantly reduced compared to the minimal gauge mediation and extended gauge mediation without focus point. The Higgs boson mass is around 125 GeV, the gauginos remain light, and the gluino is likely to be detected at the next run of the LHC. However, the multi-TeV squarks is out of the reach of the LHC. The numerical calculation for fine-tuning shows that this model remains natural

  11. A comparative study of process mediator components that support behavioral incompatibility

    CERN Document Server

    Munusamy, Kanmani; Ibrahim, Suhaimi; Baba, Mohd Sapiyan

    2011-01-01

    Most businesses these days use the web services technology as a medium to allow interaction between a service provider and a service requestor. However, both the service provider and the requestor would be unable to achieve their business goals when there are miscommunications between their processes. This research focuses on the process incompatibility between the web services and the way to automatically resolve them by using a process mediator. This paper presents an overview of the behavioral incompatibility between web services and the overview of process mediation in order to resolve the complications faced due to the incompatibility. Several state-of the-art approaches have been selected and analyzed to understand the existing process mediation components. This paper aims to provide a valuable gap analysis that identifies the important research areas in process mediation that have yet to be fully explored.

  12. Lepton-Flavor Violating Mediators

    CERN Document Server

    Galon, Iftah; Tanedo, Philip

    2016-01-01

    We present a framework where dark matter interacts with the Standard Model through a light, spin-0 mediator that couples chirally to pairs of different-flavor leptons. This flavor violating final state weakens bounds on new physics coupled to leptons from terrestrial experiments and cosmic-ray measurements. As an example, we apply this framework to construct a model for the Fermi-LAT excess of GeV $\\gamma$-rays from the galactic center. We comment on the viability of this portal for self-interacting dark matter explanations of small scale structure anomalies and embeddings in flavor models. Models of this type are shown to be compatible with the muon anomalous magnetic moment anomaly. We review current experimental constraints and identify possible future theoretical and experimental directions.

  13. Integrins mediating bone signal transduction

    Institute of Scientific and Technical Information of China (English)

    HE Chuanglong; WANG Yuanliang; YANG Lihua; ZHANG Jun

    2004-01-01

    Integrin-mediated adhesions play critical roles in diverse cell functions. Integrins offers a platform on which mechanical stimuli, cytoskeletal organization, biochemical signals can concentrate. Mechanical stimuli transmitted by integrins influence the cytoskeleton, in turn, the cytoskeleton influences cell adhesion via integrins, then cell adhesion results in a series of signal transduction cascades. In skeleton, integrins also have a key role for bone resoption by osteoclasts and reformation by osteoblasts. In present review, the proteins involved in integrin signal transduction and integrin signal transduction pathways were discussed, mainly on the basic mechanisms of integrin signaling and the roles of integrins in bone signal transduction, which may give insight into new therapeutic agents to all kinds of skeletal diseases and new strategies for bone tissue engineering.

  14. Hyaluronan-mediated cellular adhesion

    Science.gov (United States)

    Curtis, Jennifer

    2005-03-01

    Many cells surround themselves with a cushioning halo of polysaccharides that is further strengthened and organized by proteins. In fibroblasts and chrondrocytes, the primary component of this pericellular matrix is hyaluronan, a large linear polyanion. Hyaluronan production is linked to a variety of disease, developmental, and physiological processes. Cells manipulate the concentration of hyaluronan and hyaluronan receptors for numerous activities including modulation of cell adhesion, cell motility, and differentiation. Recent investigations by identify hyaluronan's role in mediating early-stage cell adhesion. An open question is how the cell removes the 0.5-10 micron thick pericellular matrix to allow for further mature adhesion events requiring nanometer scale separations. In this investigation, holographic optical tweezers are used to study the adhesion and viscoelastic properties of chondrocytes' pericellular matrix. Ultimately, we aim to shed further light on the spatial and temporal details of the dramatic transition from micron to nanometer gaps between the cell and its adhesive substrate.

  15. Endothelin receptor-mediated vasodilatation

    DEFF Research Database (Denmark)

    Nilsson, David; Wackenfors, Angelica; Gustafsson, Lotta;

    2008-01-01

    Culture of intact arteries is a frequently employed experimental model for investigating the mechanisms governing the regulation of vascular endothelin receptors. Endothelin type A (ET(A)) and type B (ET(B)) receptors on vascular smooth muscle cells are up-regulated in organ culture and the...... enhanced vasoconstriction mimics the changes that occur in cardiovascular disease. The effect of organ culture on endothelial dilatory endothelin ET(B) receptors is not known. We hypothesize that organ culture decreases the endothelin receptor-mediated dilatation and that this is one possible mechanism by...... denudation. The increase in sarafotoxin 6c contraction after removal of the endothelium was more pronounced before than after organ culture, suggesting down-regulated endothelial endothelin ET(B) receptors. Also, the immunofluorescence staining intensities for endothelial endothelin ET(B) receptors were...

  16. Phenomenological aspects of mirage mediation

    Energy Technology Data Exchange (ETDEWEB)

    Loewen, Valeri

    2009-07-15

    We consider the possibility that string theory vacua with spontaneously broken supersymmetry and a small positive cosmological constant arise due to hidden sector matter interactions, known as F-uplifting/F-downlifting. We analyze this procedure in a model-independent way in the context of type IIB and heterotic string theory. Our investigation shows that the uplifting/downlifting sector has very important consequences for the resulting phenomenology. Not only does it adjust the vacuum energy, but it can also participate in the process of moduli stabilization. In addition, we find that this sector is the dominant source of supersymmetry breaking. It leads to a hybrid mediation scheme and its signature is a relaxed mirage pattern of the soft supersymmetry breaking terms. The low energy spectra exhibit distinct phenomenological properties and di er from conventional schemes considered so far. (orig.)

  17. Protooncogenes as mediators of apoptosis.

    Science.gov (United States)

    Teng, C S

    2000-01-01

    Apoptosis has been well established as a vital biological phenomenon that is important in the maintenance of cellular homeostasis. Three major protooncogene families and their encoded proteins function as mediators of apoptosis in various cell types and are the subject of this chapter. Protooncogenic proteins such as c-Myc/Max, c-Fos/c-Jun, and Bcl-2/Bax utilize a synergetic effect to enhance their roles in the pro- or antiapoptotic action. These family members activate and repress the expression of their target genes, control cell cycle progression, and execute programmed cell death. Repression or overproduction of these protooncogenic proteins induces apoptosis, which may vary as a result of either cell type specificity or the nature of the apoptotic stimuli. The proapoptotic and antiapoptotic proteins exert their effects in the membrane of cellular organelles. Here they generate cell-type-specific signals that activate the caspase family of proteases and their regulators for the execution of apoptosis.

  18. Mediated electrochemical hazardous waste destruction

    International Nuclear Information System (INIS)

    There are few permitted processes for mixed waste (radioactive plus chemically hazardous) treatment. We are developing electrochemical processes that convert the toxic organic components of mixed waste to water, carbon dioxide, an innocuous anions such as chloride. Aggressive oxidizer ions such as Ag2+ or Ce+4 are produced at an anode. These can attack the organic molecules directly. They can also attack water which yields hydroxyl free radicals that in turn attack the organic molecules. The condensed (i.e., solid and/or liquid) effluent streams contain the inorganic radionuclide forms. These may be treated with existing technology and prepared for final disposal. Kinetics and the extent of destruction of some toxic organics have been measured. Depending on how the process is operated, coulombic efficiency can be nearly 100%. In addition, hazardous organic materials are becoming very expensive to dispose of and when they are combined with transuranic radioactive elements no processes are presently permitted. Mediated electrochemical oxidation is an ambient-temperature aqueous-phase process that can be used to oxidize organic components of mixed wastes. Problems associated with incineration, such as high-temperature volatilization of radionuclides, are avoided. Historically, Ag (2) has been used as a mediator in this process. Fe(6) and Co(3) are attractive alternatives to Ag(2) since they form soluble chlorides during the destruction of chlorinated solvents. Furthermore, silver itself is a toxic heavy metal. Quantitative data has been obtained for the complete oxidation of ethylene glycol by Fe(6) and Co(3). Though ethylene glycol is a nonhalogenated organic, this data has enabled us to make direct comparisons of activities of Fe(6) and Co(3) with Ag(2). Very good quantitative data for the oxidation of ethylene glycol by Ag(2) had already been collected. 4 refs., 6 figs

  19. AGROBACTERIUM-MEDIATED TRANSFORMATION OF WHEAT

    Directory of Open Access Journals (Sweden)

    K. Mészáros

    2008-09-01

    Full Text Available Transformation of cereals is one of the emerging areas for plant genomic and biotechnology research. Wheat was among the last major crops to be transformed by particle bombardment about 10 years ago. However, Agrobacterium-mediated transformation has several advantages over bombardment, including a reduction in copy number, fewer rearrangements and preferential integration into transcriptionally active chromosome regions. As a first step, we started to adapt an immature embryo-based transformation method for the model variety ‘Cadenza’. The regeneration of this variety was low and especially the cost of generating donor plants was high. Therefore, we decided (i to test regeneration capacity of winter and spring wheats using four different explants, (ii to determine the optimal genotype-regeneration system combinations, and (iii to work out the details of mature embryo transformation with Agrobacterium. The experiment was carried out with 16 cultivated winter wheat and 2 model spring wheat varieties. Four different explants: anther, immature embryo, mature embryo and dry seed were tested for callus induction and plant regeneration. The regeneration capacity was the lowest in the case of anther culture and ranged from 20% (‘Mv Béres’ to 0.1% (‘Mv Magvas’ with four varieties exerting significantly higher regeneration than ‘Cadenza’. Plant regeneration from immature embryos ranged between 59% (‘Mv Regiment’ and 0.1% (‘Mv Toborzó’. Again, four varieties produced significantly more plants than the control ‘Cadenza’. We tested two systems for the plant regeneration from mature embryos. First, mature embryos were isolated from seeds, which resulted in an average of 17% plant regeneration (from 63% in ‘Fatima’ to zero in ‘Mv Palotás’. ‘Cadenza’ was one of the worse regenerating genotype (7%. The highest plant regeneration (average 54% was in the case of seed explants. There were no significant differences

  20. Modeling expert knowledge in the mediation domain: a mediation core ontology

    OpenAIRE

    Poblet, Marta; Casanovas, Pompeu

    2009-01-01

    In this paper we introduce the Mediation Core Ontology (MCO), and the steps taken in order to model the expert knowledge on the mediation domain. MCO is created from scratch by eliciting practical knowledge from mediation experts to identify the basic working concepts of the domain. MCO offers initial support towards knowledge acquisition and reasoning and, in later steps, will serve as a general basis for the development of different mediation domain and sub-domain ontologies to be used by ...

  1. Fast prediction of cytochrome P450 mediated drug metabolism

    DEFF Research Database (Denmark)

    Rydberg, Patrik Åke Anders; Poongavanam, Vasanthanathan; Oostenbrink, Chris;

    2009-01-01

    % of the metabolites. The rules employed are relatively few and general, and when combined with solvent-accessible surface area calculations to account for steric accessibility, the method gives a major P450 metabolite as first-ranked position for 75 % of the substrates, and ranked in the top three for 90......Cytochrome P450 mediated metabolism of drugs is one of the major determinants of their kinetic profile, and prediction of this metabolism is therefore highly relevant during the drug discovery and development process. A new rule-based method, based on results from density functional theory...

  2. Tests of Mediation: Paradoxical Decline in Statistical Power as a Function of Mediator Collinearity

    Science.gov (United States)

    Beasley, T. Mark

    2014-01-01

    Increasing the correlation between the independent variable and the mediator ("a" coefficient) increases the effect size ("ab") for mediation analysis; however, increasing a by definition increases collinearity in mediation models. As a result, the standard error of product tests increase. The variance inflation caused by…

  3. Forms of Mediation: The Case of Interpreter-Mediated Interactions in Medical Systems

    Science.gov (United States)

    Baraldi, Claudio

    2009-01-01

    This paper analyses the forms of mediation in interlinguistic interactions performed in Italian healthcare services and in contexts of migration. The literature encourages dialogic transformative mediation, empowering participants' voices and changing cultural presuppositions in social systems. It may be doubtful, however, whether mediation can…

  4. Motion-induced blindness and Troxler fading: common and different mechanisms

    NARCIS (Netherlands)

    Y.S. Bonneh; T.H. Donner; A. Cooperman; D.J. Heeger; D. Sagi

    2014-01-01

    Extended stabilization of gaze leads to disappearance of dim visual targets presented peripherally. This phenomenon, known as Troxler fading, is thought to result from neuronal adaptation. Intense targets also disappear intermittently when surrounded by a moving pattern (the "mask"), a phenomenon kn

  5. Enhanced perceptions of control and predictability reduce motion-induced nausea and gastric dysrhythmia.

    Science.gov (United States)

    Levine, Max E; Stern, Robert M; Koch, Kenneth L

    2014-08-01

    Nausea is a debilitating condition that is typically accompanied by gastric dysrhythmia. The enhancement of perceived control and predictability has generally been found to attenuate the physiological stress response. The aim of the present study was to test the effect of these psychosocial variables in the context of nausea, motion sickness, and gastric dysrhythmia. A 2x2, independent-groups, factorial design was employed in which perceived control and predictability were each provided at high or low levels to 80 participants before exposure to a rotating optokinetic drum. Ratings of nausea were obtained throughout a 6-min baseline period and a 16-min drum rotation period. Noninvasive recordings of the electrical activity of the stomach called electrogastrograms were also obtained throughout the study. Nausea scores were significantly lower among participants with high control than among those with low control, and were significantly lower among participants with high predictability than among those with low predictability. Estimates of gastric dysrhythmia obtained from the EGG during drum rotation were significantly lower among participants with high predictability than among those with low predictability. A significant interaction effect of control and predictability on gastric dysrhythmia was also observed, such that high control was only effective for arresting the development of gastric dysrhythmia when high predictability was also available. Stronger perceptions of control and predictability may temper the development of nausea and gastric dysrhythmia during exposure to provocative motion. Psychosocial interventions in a variety of nausea contexts may represent an alternative means of symptom control.

  6. Motion induced passenger dislocations in life raft and life boat configurations

    NARCIS (Netherlands)

    Bos, J.E.; Andersen ,O.; Reinke, P.

    2010-01-01

    Within the European project SafeCrafts, dealing with the safe abandoning of ships, the dislocation of passengers aboard life boats and rafts has been considered to be a risk regarding passenger survival at sea. To get an idea about the risks and the affecting factors involved, we studied the effects

  7. Bursting-like motion induced by time-varying delay in an internet congestion control model

    Institute of Scientific and Technical Information of China (English)

    Shu Zhang; Jian Xu

    2012-01-01

    Time delay is an important parameter in the problem of internet congestion control.According to some researches,time delay is not always constant and can be viewed as a periodic function of time for some cases.In this work,an internet congestion control model is considered to study the time-varying delay induced bursting-like motion,which consists of a rapid oscillation burst and quiescent steady state.Then,for the system with periodic delay of small amplitude and low frequency,the method of multiple scales is employed to obtain the amplitude of the oscillation.Based on the expression of the asymptotic solution,it can be found that the relative length of the steady state increases with amplitude of the variation of time delay and decreases with frequency of the variation of time delay.Finally,an effective method to control the bursting-like motion is proposed by introducing a periodic gain parameter with appropriate amplitude.Theoretical results are in agreement with that from numerical method.

  8. DNA motion induced by electrokinetic flow near an Au coated nanopore surface as voltage controlled gate

    International Nuclear Information System (INIS)

    We used fluorescence microscopy to investigate the diffusion and drift motion of λ DNA molecules on an Au-coated membrane surface near nanopores, prior to their translocation through solid-state nanopores. With the capability of controlling electric potential at the Au surface as a gate voltage, Vgate, the motions of DNA molecules, which are presumably generated by electrokinetic flow, vary dramatically near the nanopores in our observations. We carefully investigate these DNA motions with different values of Vgate in order to alter the densities and polarities of the counterions, which are expected to change the flow speed or direction, respectively. Depending on Vgate, our observations have revealed the critical distance from a nanopore for DNA molecules to be attracted or repelled—DNA’s anisotropic and unsteady drifting motions and accumulations of DNA molecules near the nanopore entrance. Further finite element method (FEM) numerical simulations indicate that the electrokinetic flow could qualitatively explain these unusual DNA motions near metal-collated gated nanopores. Finally, we demonstrate the possibility of controlling the speed and direction of DNA motion near or through a nanopore, as in the case of recapturing a single DNA molecule multiple times with alternating current voltages on the Vgate. (paper)

  9. Measuring Motion-Induced B0-Fluctuations in the Brain Using Field Probes

    DEFF Research Database (Denmark)

    Andersen, Mads; Hanson, Lars G.; Madsen, Kristoffer H.;

    2016-01-01

    Purpose: Fluctuations of the background magnetic field (B0) due to body and breathing motion can lead to significant artifacts in brain imaging at ultrahigh field. Corrections based on real-time sensing using external field probes show great potential. This study evaluates different aspects...... of field interpolation from these probes into the brain which is implicit in such methods. Measurements and simulations were performed to quantify how well B0-fluctuations in the brain due to body and breathing motion are reflected in external field probe measurements. Methods: Field probe measurements...... were compared with scanner acquired B0-maps from experiments with breathing and shoulder movements. A realistic simulation of B0-fluctuations caused by breathing was performed, and used for testing different sets of field probe positions. Results: The B0-fluctuations were well reflected in the field...

  10. Repetitive arm motion-induced fatigue affects shoulder but not endpoint position sense.

    Science.gov (United States)

    Emery, Kim; Côté, Julie N

    2012-02-01

    Neck/shoulder pain has previously been linked to repetitive work and muscle fatigue. We have shown that asymptomatic people performing repetitive upper limb tasks display signs of shoulder fatigue and of whole-body compensatory strategies. However, the role played by the proprioceptive system in the production of these compensatory strategies has not been studied. A group of asymptomatic adults (n = 18) performed a repetitive pointing task at shoulder height to fatigue. Before and after fatigue, they performed two position sense tasks, eyes closed: a single-joint task where they abducted their shoulder to the perceived horizontal and a multi-joint task, where they stood and placed their finger at the perceived location of a target in front of them at shoulder height. After fatigue, subjects made larger shoulder errors by raising their elbow higher above the horizontal (~ +1.3 cm) than before fatigue; however, their finger position accuracy was not changed, despite all subjects performing the movement in less time (~ -0.18 s) while fatigued. There were no gender differences in shoulder or finger position accuracy before or after fatigue; however, there were gender differences in the perceived finger-target location and in the temporal characteristics of the finger movement toward the target. Results suggest that healthy individuals are able to develop strategies to compensate for fatigue-induced deficits at one joint to maintain the endpoint accuracy of a multi-joint task constant. Gender differences in movement strategies and perception of endpoint location may play parts in the previously reported gender differences in work-related neck/shoulder symptoms. PMID:22124803

  11. Enhanced perceptions of control and predictability reduce motion-induced nausea and gastric dysrhythmia.

    Science.gov (United States)

    Levine, Max E; Stern, Robert M; Koch, Kenneth L

    2014-08-01

    Nausea is a debilitating condition that is typically accompanied by gastric dysrhythmia. The enhancement of perceived control and predictability has generally been found to attenuate the physiological stress response. The aim of the present study was to test the effect of these psychosocial variables in the context of nausea, motion sickness, and gastric dysrhythmia. A 2x2, independent-groups, factorial design was employed in which perceived control and predictability were each provided at high or low levels to 80 participants before exposure to a rotating optokinetic drum. Ratings of nausea were obtained throughout a 6-min baseline period and a 16-min drum rotation period. Noninvasive recordings of the electrical activity of the stomach called electrogastrograms were also obtained throughout the study. Nausea scores were significantly lower among participants with high control than among those with low control, and were significantly lower among participants with high predictability than among those with low predictability. Estimates of gastric dysrhythmia obtained from the EGG during drum rotation were significantly lower among participants with high predictability than among those with low predictability. A significant interaction effect of control and predictability on gastric dysrhythmia was also observed, such that high control was only effective for arresting the development of gastric dysrhythmia when high predictability was also available. Stronger perceptions of control and predictability may temper the development of nausea and gastric dysrhythmia during exposure to provocative motion. Psychosocial interventions in a variety of nausea contexts may represent an alternative means of symptom control. PMID:24748483

  12. SELKIRK ROADLESS AREA, IDAHO.

    Science.gov (United States)

    Miller, Fred K.; Benham, John R.

    1984-01-01

    On the basis of mineral-resource surveys the Selkirk Roadless Area, Idaho has little promise for the occurrence of mineral or energy resources. Molybdenum, lead, uranium, thorium, chromium, tungsten, zirconium, and several rare-earth elements have been detected in panned concentrates from samples of stream sediment, but no minerals containing the first five elements were found in place, nor were any conditions conducive to their concentration found. Zirconium, thorium, and the rare earths occur in sparsely disseminated accessory minerals in granitic rocks and no resource potential is identified. There is no history of mining in the roadless area and there are no oil, gas, mineral, or geothermal leases or current claims.

  13. Screening for domestic violence in family mediation: an investigation into how mediators manage disclosures of domestic abuse and associated emotions

    OpenAIRE

    Morris, Paulette Elaine

    2015-01-01

    This thesis was submitted for the award of Doctor of Philosophy and was awarded by Brunel University London This thesis explores the practice of family mediators when screening for domestic violence during mediation. Mediation Information and Assessment Meetings (MIAMs) and Joint Mediation Meetings (JMs) were recorded between April 2010 and January 2011, by four mediators who mediate for National Family Mediation (NFM) affiliated services in the South of England. These meetings were analys...

  14. Integrating Mediators and Moderators in Research Design

    Science.gov (United States)

    MacKinnon, David P.

    2011-01-01

    The purpose of this article is to describe mediating variables and moderating variables and provide reasons for integrating them in outcome studies. Separate sections describe examples of moderating and mediating variables and the simplest statistical model for investigating each variable. The strengths and limitations of incorporating mediating…

  15. Elaborative Retrieval: Do Semantic Mediators Improve Memory?

    Science.gov (United States)

    Lehman, Melissa; Karpicke, Jeffrey D.

    2016-01-01

    The elaborative retrieval account of retrieval-based learning proposes that retrieval enhances retention because the retrieval process produces the generation of semantic mediators that link cues to target information. We tested 2 assumptions that form the basis of this account: that semantic mediators are more likely to be generated during…

  16. Que Es la Mediacion? (What Is Mediation?).

    Science.gov (United States)

    Consortium for Appropriate Dispute Resolution in Special Education (CADRE), Eugene, OR.

    This brief paper, in Spanish, discusses the use of mediation as a method for resolving disagreements between schools or early intervention programs and parents of children with disabilities. It identifies benefits of mediation such as maintenance of an ongoing and positive relationship between the school and family, simple resolution of conflicts…

  17. Semiotic Mediation within an AT Frame

    Science.gov (United States)

    Maracci, Mirko; Mariotti, Maria Alessandra

    2013-01-01

    This article is meant to present a specific elaboration of the notion of mediation in relation to the use of artefacts to enhance mathematics teaching and learning: the elaboration offered by the Theory of Semiotic Mediation. In particular, it provides an explicit model--consistent with the activity-actions-operations framework--of the actions…

  18. Intercultural Conflict and Mediation: An Intergroup Perspective

    Science.gov (United States)

    Rubenfeld, Sara; Clement, Richard

    2012-01-01

    This study investigates the role of components of intercultural competence in the use of intercultural mediation behaviors. Through the use of the Revised Intercultural Mediation Measure, an instrument revised by the authors, 291 Anglophone and 161 Francophone participants in Canada were asked to indicate their likelihood of employing various…

  19. Parent Mediation Empowers Sibling Conflict Resolution

    Science.gov (United States)

    Ross, Hildy S.; Lazinski, Marysia J.

    2014-01-01

    Research Findings: For the current study, formal mediation procedures were adapted for families and parents were trained and asked to mediate their children's disputes; control group parents intervened as they normally would. Conflict negotiations with parents and their children (ages 3½-11 years) occurring 3 and 7 weeks following training,…

  20. The Mediator Role in Social Work Practice.

    Science.gov (United States)

    Parsons, Ruth J.

    1991-01-01

    Notes that mediation as problem-solving intervention in social work became widely used in child custody and divorce cases, child-parent conflicts, and family disputes. Argues that mediator role is inherent in social work, and examines context for and assumptions underlying it. Discusses nature of conflicts, issue of neutrality within social work…

  1. Plutonium focus area

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    To ensure research and development programs focus on the most pressing environmental restoration and waste management problems at the U.S. Department of Energy (DOE), the Assistant Secretary for the Office of Environmental Management (EM) established a working group in August 1993 to implement a new approach to research and technology development. As part of this new approach, EM developed a management structure and principles that led to the creation of specific Focus Areas. These organizations were designed to focus the scientific and technical talent throughout DOE and the national scientific community on the major environmental restoration and waste management problems facing DOE. The Focus Area approach provides the framework for intersite cooperation and leveraging of resources on common problems. After the original establishment of five major Focus Areas within the Office of Technology Development (EM-50, now called the Office of Science and Technology), the Nuclear Materials Stabilization Task Group (EM-66) followed the structure already in place in EM-50 and chartered the Plutonium Focus Area (PFA). The following information outlines the scope and mission of the EM, EM-60, and EM-66 organizations as related to the PFA organizational structure.

  2. Local Area Networks.

    Science.gov (United States)

    Marks, Kenneth E.; Nielsen, Steven

    1991-01-01

    Discusses cabling that is needed in local area networks (LANs). Types of cables that may be selected are described, including twisted pair, coaxial cables (or ethernet), and fiber optics; network topologies, the manner in which the cables are laid out, are considered; and cable installation issues are discussed. (LRW)

  3. Subsurface contaminants focus area

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    The US Department of Enregy (DOE) Subsurface Contaminants Focus Area is developing technologies to address environmental problems associated with hazardous and radioactive contaminants in soil and groundwater that exist throughout the DOE complex, including radionuclides, heavy metals; and dense non-aqueous phase liquids (DNAPLs). More than 5,700 known DOE groundwater plumes have contaminated over 600 billion gallons of water and 200 million cubic meters of soil. Migration of these plumes threatens local and regional water sources, and in some cases has already adversely impacted off-site rsources. In addition, the Subsurface Contaminants Focus Area is responsible for supplying technologies for the remediation of numerous landfills at DOE facilities. These landfills are estimated to contain over 3 million cubic meters of radioactive and hazardous buried Technology developed within this specialty area will provide efective methods to contain contaminant plumes and new or alternative technologies for development of in situ technologies to minimize waste disposal costs and potential worker exposure by treating plumes in place. While addressing contaminant plumes emanating from DOE landfills, the Subsurface Contaminants Focus Area is also working to develop new or alternative technologies for the in situ stabilization, and nonintrusive characterization of these disposal sites.

  4. Protected areas in mountains

    Directory of Open Access Journals (Sweden)

    Hamilton, L. S.

    2006-12-01

    Full Text Available

    The importance of a global Protected Areas Network in sustaining appropriate mountain development is presented in this paper. Present status of the world’s “official” Protected Areas in the UN List, and the proportion that are in mountain areas, and including international designations (World Heritage and Biosphere Reserves. Current and future challenges in the management of these special areas are also commented.



    El autor destaca la importancia de una Red Mundial de Espacios Protegidos para el desarrollo sostenible de las montañas. Comenta luego el estatus actual de las Áreas Protegidas “oficiales” del Mundo en la Lista de las Naciones Unidas y qué proporción de ellas forma parte de las montañas, sin olvidar las figuras internacionales de protección como Patrimonio de la Humanidad y Reservas de Biosfera. Para terminar, se discuten los problemas de gestión actuales y futuros de estas áreas tan especiales

  5. Area Handbook for Syria.

    Science.gov (United States)

    Nyrop, Richard; And Others

    This volume on Syria is one of a series of handbooks prepared by the Foreign Area Studies (FAS) of the American University, designed to be useful to military and other personnel who need a convenient compilation of basic facts about the social, economic, political, and military institutions and practices of various countries. The emphasis is on…

  6. Content Area Vocabulary Learning

    Science.gov (United States)

    Fisher, Douglas; Frey, Nancy

    2014-01-01

    Students' vocabulary knowledge is a significant predictor of their overall comprehension. The Common Core State Standards are raising the expectations for word learning and there are now 4 distinct standards related to vocabulary as well as expectations in other standards, including content areas. To address these expectations, teachers need…

  7. Tangrams and Area.

    Science.gov (United States)

    Duke, Charlotte

    1998-01-01

    Presents an activity for demonstrating the area of five geometric figures--the square, the rectangle, the parallelogram, the triangle, and the trapezoid--that is based on a simple tangram puzzle. Suggests ways in which this activity can be used at several different levels. (ASK)

  8. Subsurface contaminants focus area

    International Nuclear Information System (INIS)

    The US Department of Enregy (DOE) Subsurface Contaminants Focus Area is developing technologies to address environmental problems associated with hazardous and radioactive contaminants in soil and groundwater that exist throughout the DOE complex, including radionuclides, heavy metals; and dense non-aqueous phase liquids (DNAPLs). More than 5,700 known DOE groundwater plumes have contaminated over 600 billion gallons of water and 200 million cubic meters of soil. Migration of these plumes threatens local and regional water sources, and in some cases has already adversely impacted off-site rsources. In addition, the Subsurface Contaminants Focus Area is responsible for supplying technologies for the remediation of numerous landfills at DOE facilities. These landfills are estimated to contain over 3 million cubic meters of radioactive and hazardous buried Technology developed within this specialty area will provide efective methods to contain contaminant plumes and new or alternative technologies for development of in situ technologies to minimize waste disposal costs and potential worker exposure by treating plumes in place. While addressing contaminant plumes emanating from DOE landfills, the Subsurface Contaminants Focus Area is also working to develop new or alternative technologies for the in situ stabilization, and nonintrusive characterization of these disposal sites

  9. Flavorful hybrid anomaly-gravity mediation

    CERN Document Server

    Gross, Christian

    2011-01-01

    We consider supersymmetric models where anomaly- and gravity mediation give comparable contributions to the soft terms and discuss how this can be realized in a 5-dimensional brane world. The gaugino mass pattern of anomaly mediation is preserved in such a hybrid setup. The flavorful gravity mediated contribution cures the tachyonic slepton problem of anomaly mediation. The supersymmetric flavor puzzle is solved by alignment. We explicitly show how a working flavor-tachyon link can be realized with Abelian flavor symmetries and give the characteristic signatures of the framework, including O(1) slepton mass splittings between different generations and between doublets and singlets. This provides opportunities for same flavor dilepton edge measurements with missing energy at the Large Hadron Collider (LHC). Rare lepton decay rates could be close to their current experimental limit. Compared to pure gravity mediation, the hybrid model is advantageous because it features a heavy gravitino which can avoid the cos...

  10. (Extra)Ordinary Gauge/Anomaly Mediation

    CERN Document Server

    Kobayashi, Tatsuo; Sakai, Manabu

    2011-01-01

    We study anomaly mediation models with gauge mediation effects from messengers which have a general renormalizable mass matrix with a supersymmetry-breaking spurion. Our models lead to a rich structure of supersymmetry breaking terms in the visible sector. We derive sum rules among the soft scalar masses for each generation. Our sum rules for the first and second generations are the same as those in general gauge mediation, but the sum rule for the third generation is different because of the top Yukawa coupling. We find the parameter space where the tachyonic slepton problem is solved. We also explore the case in which gauge mediation causes the anomalously small gaugino masses. Since anomaly mediation effects on the gaugino masses exist, we can obtain viable mass spectrum of the visible sector fields.

  11. Confounding in the Estimation of Mediation Effects.

    Science.gov (United States)

    Li, Yan; Bienias, Julia L; Bennett, David A

    2007-03-01

    A mediation effect explains the relationship of a risk factor and an outcome through a mediator variable which is a step in their pathway. Under the assumption of no cycling in the causal relationship, we consider various situations in which a fourth variable may interfere the estimation of a mediation effect as a confounding factor. Our asymptotic results, which are supported by a Monte Carlo study, show that adjusting for confounding factors under certain conditions might lead to biased estimates. A general guideline is provided for when it is appropriate to adjust for confounding factors in estimating a mediation effect. We apply the guideline to the estimation of the mediation effect of Alzheimer's disease pathology in the relationship between the Apolipoprotein E ε4 allele and cognitive function among 125 deceased participants from the Religious Orders Study, a longitudinal, clinical-pathologic study of aging and Alzheimer's disease. PMID:17940582

  12. Integrating Mediators and Moderators in Research Design.

    Science.gov (United States)

    Mackinnon, David P

    2011-11-01

    The purpose of this article is to describe mediating variables and moderating variables and provide reasons for integrating them in outcome studies. Separate sections describe examples of moderating and mediating variables and the simplest statistical model for investigating each variable. The strengths and limitations of incorporating mediating and moderating variables in a research study are discussed as well as approaches to routinely including these variables in outcome research. The routine inclusion of mediating and moderating variables holds the promise of increasing the amount of information from outcome studies by generating practical information about interventions as well as testing theory. The primary focus is on mediating and moderating variables for intervention research but many issues apply to nonintervention research as well.

  13. Pure Mediated Priming: A Retrospective Semantic Matching Model

    Science.gov (United States)

    Jones, Lara L.

    2010-01-01

    Mediated priming refers to the activation of a target (e.g., "stripes") by a prime (e.g., "lion") that is related indirectly via a connecting mediator (e.g., tiger). In previous mediated priming studies (e.g., McNamara & Altarriba, 1988), the mediator was associatively related to the prime. In contrast, pure mediated priming (e.g., "spoon" [right…

  14. 7 CFR 785.5 - Fees for mediation services.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Fees for mediation services. 785.5 Section 785.5... AGRICULTURE SPECIAL PROGRAMS CERTIFIED STATE MEDIATION PROGRAM § 785.5 Fees for mediation services. A requirement that non-USDA parties who elect to participate in mediation pay a fee for mediation services...

  15. Online-Mediation - Erweist sich Online-Mediation als taugliches Instrument in Österreich?

    Directory of Open Access Journals (Sweden)

    Daniela Hinterhölzl-Widi

    2010-10-01

    Full Text Available Die vorliegende Arbeit beschäftigt sich mit der Thematik der Online-Mediation in Österreich. Es wird in einem breiten Bogen von relevanten Themen der Mediation das Tool Online-Mediation betrachtet und versucht das Wie und Was der Einsatzmöglichkeiten von Online-Mediation herauszuarbeiten. Die Fragestellung beschäftigt sich damit, ob Online-Mediation als Instrument und Methode gesehen wird und ob die Mediatoren über ausreichend Know-how in Online-Kommunikation verfügen.

  16. Online-Mediation - Erweist sich Online-Mediation als taugliches Instrument in Österreich?

    OpenAIRE

    Daniela Hinterhölzl-Widi

    2010-01-01

    Die vorliegende Arbeit beschäftigt sich mit der Thematik der Online-Mediation in Österreich. Es wird in einem breiten Bogen von relevanten Themen der Mediation das Tool Online-Mediation betrachtet und versucht das Wie und Was der Einsatzmöglichkeiten von Online-Mediation herauszuarbeiten. Die Fragestellung beschäftigt sich damit, ob Online-Mediation als Instrument und Methode gesehen wird und ob die Mediatoren über ausreichend Know-how in Online-Kommunikation verfügen.

  17. Atomic Force Microscope Mediated Chromatography

    Science.gov (United States)

    Anderson, Mark S.

    2013-01-01

    The atomic force microscope (AFM) is used to inject a sample, provide shear-driven liquid flow over a functionalized substrate, and detect separated components. This is demonstrated using lipophilic dyes and normal phase chromatography. A significant reduction in both size and separation time scales is achieved with a 25-micron-length column scale, and one-second separation times. The approach has general applications to trace chemical and microfluidic analysis. The AFM is now a common tool for ultra-microscopy and nanotechnology. It has also been demonstrated to provide a number of microfluidic functions necessary for miniaturized chromatography. These include injection of sub-femtoliter samples, fluidic switching, and sheardriven pumping. The AFM probe tip can be used to selectively remove surface layers for subsequent microchemical analysis using infrared and tip-enhanced Raman spectroscopy. With its ability to image individual atoms, the AFM is a remarkably sensitive detector that can be used to detect separated components. These diverse functional components of microfluidic manipulation have been combined in this work to demonstrate AFM mediated chromatography. AFM mediated chromatography uses channel-less, shear-driven pumping. This is demonstrated with a thin, aluminum oxide substrate and a non-polar solvent system to separate a mixture of lipophilic dyes. In conventional chromatographic terms, this is analogous to thin-layer chromatography using normal phase alumina substrate with sheardriven pumping provided by the AFM tip-cantilever mechanism. The AFM detection of separated components is accomplished by exploiting the variation in the localized friction of the separated components. The AFM tip-cantilever provides the mechanism for producing shear-induced flows and rapid pumping. Shear-driven chromatography (SDC) is a relatively new concept that overcomes the speed and miniaturization limitations of conventional liquid chromatography. SDC is based on a

  18. Role of Transformational Leadership in Effective Organizational Knowledge Creation Practices: Mediating Effects of Employees' Work Engagement

    Science.gov (United States)

    Song, Ji Hoon; Kolb, Judith A.; Lee, Ung Hee; Kim, Hye Kyoung

    2012-01-01

    Engagement as an area of increasing interest has been discussed in terms of a wide array of organizational policies, practices, and outcomes. This study focuses on a specific aspect of work engagement and its relationship with leadership practices and the outcome of knowledge creation. The mediating effect of employees' work engagement level was…

  19. Effects of Training on Computer-Mediated Communication in Single or Mixed Gender Small Task Groups.

    Science.gov (United States)

    Savicki, Victor; Kelley, Merle; Ammon, Benjamin

    2002-01-01

    Investigates group gender composition and communication styles in small task groups involved in computer-mediated communication. Describes a study that tried to train small task groups in the use of one communication style and suggests further research in the area of communication training for online task groups. (Author/LRW)

  20. Effects of Gender on Computer-Mediated Communication: A Survey of University Faculty

    Science.gov (United States)

    Valenziano, Laura

    2007-01-01

    The influence of gender on computer-mediated communication is a research area with tremendous growth. This study sought to determine what gender effects exist in email communication between professors and students. The study also explored the amount of lying and misinterpretation that occurs through online communication. The study results indicate…

  1. Social Capital as a Mediating Factor in Emergency Preparedness and Concerns about Terrorism

    Science.gov (United States)

    Hausman, Alice J.; Hanlon, Alexandra; Seals, Brenda

    2007-01-01

    The purpose of this study was to investigate how social capital might be instrumental in mediating concerns about terrorism and promoting appropriate responses for emergency preparedness. Results are presented from a random-digit dialed survey of a metropolitan area measuring individual characteristics as well as community-level characteristics as…

  2. Sulphur bacteria mediated formation of Palaeoproterozoic phosphorites

    Science.gov (United States)

    Joosu, Lauri; Lepland, Aivo; Kirsimäe, Kalle

    2014-05-01

    Modern phosphorite formation is typically associated with high productivity in upwelling areas where apatite (Ca-phosphate) precipitation is mediated by sulphur oxidising bacteria [1]. They inhabit the oxic/anoxic interface within the upper few centimetres of sediment column, accumulating phosphate in their cells under oxic conditions and releasing it rapidly when conditions become anoxic. Sulphur bacteria are known to live in close association with a consortium of anaerobic methane oxidising archaea and syntrophic sulphate-reducing bacteria. Paleoproterozoic, c. 2.0 Ga Zaonega Formation in Karelia, Russia contains several P-rich intervals in the upper part of 1500 m thick succession of organic-rich sedimentary rocks interlayered with mafic tuffs and lavas. Apatite in these P-rich intervals forms impure laminae, lenses and round-oval nodules which diameters typically range from 300 to 1000 μm. Individual apatite particles in P-rich laminae and nodules commonly occur as cylinders that are 1-8 μm long and have diameters of 0.5-4 μm. Cross-sections of best preserved cylindrical apatite particles reveal a thin outer rim whereas the internal parts consist of small anhedral elongated crystallites, intergrown with carbonaceous material. During recrystallization the outer rim thickens towards interior and cylinders may attain hexagonal crystal habit, but their size and shape remains largely unchanged [2]. The sizes of Zaonega nodules are similar to giant sulphide-oxidising bacteria known from modern and ancient settings [3, 4]. Individual apatite cylinders and aggregates have shapes and sizes similar to the methanotrophic archaea that inhabit microbial mats in modern seep/vent areas where they operate in close associations with sulphur-oxidising microbial communities [5]. Seep/vent influence during the Zaonega phosphogenesis is indicated by variable, though positive Eu anomaly, expected in magmatically active sedimentary environment experiencing several lava flows

  3. Nucleotide-mediated airway clearance.

    Science.gov (United States)

    Schmid, Andreas; Clunes, Lucy A; Salathe, Mathias; Verdugo, Pedro; Dietl, Paul; Davis, C William; Tarran, Robert

    2011-01-01

    A thin layer of airway surface liquid (ASL) lines the entire surface of the lung and is the first point of contact between the lung and the environment. Surfactants contained within this layer are secreted in the alveolar region and are required to maintain a low surface tension and to prevent alveolar collapse. Mucins are secreted into the ASL throughout the respiratory tract and serve to intercept inhaled pathogens, allergens and toxins. Their removal by mucociliary clearance (MCC) is facilitated by cilia beating and hydration of the ASL by active ion transport. Throughout the lung, secretion, ion transport and cilia beating are under purinergic control. Pulmonary epithelia release ATP into the ASL which acts in an autocrine fashion on P2Y(2) (ATP) receptors. The enzymatic network describes in Chap. 2 then mounts a secondary wave of signaling by surface conversion of ATP into adenosine (ADO), which induces A(2B) (ADO) receptor-mediated responses. This chapter offers a comprehensive description of MCC and the extensive ramifications of the purinergic signaling network on pulmonary surfaces. PMID:21560046

  4. Protease-mediated drug delivery

    Science.gov (United States)

    Dickson, Eva F.; Goyan, Rebecca L.; Kennedy, James C.; Mackay, M.; Mendes, M. A. K.; Pottier, Roy H.

    2003-12-01

    Drugs used in disease treatment can cause damage to both malignant and normal tissue. This toxicity limits the maximum therapeutic dose. Drug targeting is of high interest to increase the therapeutic efficacy of the drug without increasing systemic toxicity. Certain tissue abnormalities, disease processes, cancers, and infections are characterized by high levels of activity of specific extracellular and/or intracellular proteases. Abnormally high activity levels of specific proteases are present at sites of physical or chemical trauma, blood clots, malignant tumors, rheumatoid arthritis, inflammatory bowel disease, gingival disease, glomerulonerphritis, and acute pancreatitis. Abnormal protease activity is suspected in development of liver thrombosis, pulmonary emphysema, atherosclerosis, and muscular dystrophy. Inactiviating disease-associated proteases by the administration of appropriate protease inhibitors has had limited success. Instead, one could use such proteases to target drugs to treat the condition. Protease mediated drug delivery offers such a possibility. Solubilizing groups are attached to insoluble drugs via a polypeptide chain which is specifically cleavable by certian proteases. When the solubilized drug enounters the protease, the solubilizing moieties are cleaved, and the drug precipitates at the disease location. Thus, a smaller systemic dosage could result in a therapeutic drug concentration at the treatment site with less systemic toxicity.

  5. Gauge mediation with light stops

    CERN Document Server

    Delgado, Antonio; Quiros, Mariano

    2015-01-01

    The mechanism of gauge mediated supersymmetry breaking (GMSB) solves the supersymmetric flavor problem although it requires superheavy stops to reproduce the experimental value (125 GeV) of the Higgs mass. A possible way out is to extend the MSSM Higgs sector with triplets which provide extra tree-level corrections to the Higgs mass. Triplets with neutral components getting vacuum expectation values (VEV) have the problem of generating a tree-level correction to the \\rho parameter. We introduce supersymmetric triplets with hypercharges Y=(0,\\pm 1), with a tree-level custodial SU(2)_L\\otimes SU(2)_R global symmetry in the Higgs sector protecting the \\rho parameter: a supersymmetric generalization of the Georgi-Machacek model. The renormalization group running from the messenger to the electroweak scale mildly breaks the custodial symmetry. We will present realistic low-scale scenarios, their main features being a Bino-like neutralino or right-handed stau as the NLSP, light (1 TeV) stops, exotic couplings (H^\\p...

  6. Immunomodulatory Effects Mediated by Dopamine

    Directory of Open Access Journals (Sweden)

    Rodrigo Arreola

    2016-01-01

    Full Text Available Dopamine (DA, a neurotransmitter in the central nervous system (CNS, has modulatory functions at the systemic level. The peripheral and central nervous systems have independent dopaminergic system (DAS that share mechanisms and molecular machinery. In the past century, experimental evidence has accumulated on the proteins knowledge that is involved in the synthesis, reuptake, and transportation of DA in leukocytes and the differential expression of the D1-like (D1R and D5R and D2-like receptors (D2R, D3R, and D4R. The expression of these components depends on the state of cellular activation and the concentration and time of exposure to DA. Receptors that are expressed in leukocytes are linked to signaling pathways that are mediated by changes in cAMP concentration, which in turn triggers changes in phenotype and cellular function. According to the leukocyte lineage, the effects of DA are associated with such processes as respiratory burst, cytokine and antibody secretion, chemotaxis, apoptosis, and cytotoxicity. In clinical conditions such as schizophrenia, Parkinson disease, Tourette syndrome, and multiple sclerosis (MS, there are evident alterations during immune responses in leukocytes, in which changes in DA receptor density have been observed. Several groups have proposed that these findings are useful in establishing clinical status and clinical markers.

  7. Towards the Natural Gauge Mediation

    CERN Document Server

    Ding, Ran; Wang, Liucheng; Zhu, Bin

    2015-01-01

    The sweet spot supersymmetry (SUSY) solves the mu problem in the Minimal Supersymmetric Standard Model (MSSM) with gauge mediated SUSY breaking (GMSB) via the generalized Giudice-Masiero (GM) mechanism where only the mu-term and soft Higgs masses are generated at the unification scale of the Grand Unified Theory (GUT) due to the approximate PQ symmetry. Because all the other SUSY breaking soft terms are generated via the GMSB below the GUT scale, there exists SUSY electroweak (EW) fine-tuning problem to explain the 125 GeV Higgs boson mass due to small trilinear soft term. Thus, to explain the Higgs boson mass, we propose the GMSB with both the generalized GM mechanism and Higgs-messenger interactions. The renormalization group equations are runnings from the GUT scale down to EW scale. So the EW symmetry breaking can be realized easier. We can keep the gauge coupling unification and solution to the flavor problem in the GMSB, as well as solve the \\mu/B_{\\mu}-problem. Moreover, there are only five free parame...

  8. All Conservation Opportunity Areas (ECO.RES.ALL_OP_AREAS)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The All_OP_Areas GIS layer are all the Conservation Opportunity Areas identified by MoRAP (produced for EPA Region 7). They designate areas with potential for...

  9. Geoconservation and protected areas

    OpenAIRE

    Brilha, J. B.

    2002-01-01

    Conservation will fail if nature conservation policies impose artificial boundaries on the natural world. The protected area manager’s main task is biodiversity preservation. Nevertheless, nature conservation requires a broad perspective. Incorporating geology into conservation policies at the same level as biology is urgent. The slow rate of many geological processes leads to the misconception that geological resources are inexhaustible and immutable. Geologists know that this is not true an...

  10. Research Areas in Literature

    OpenAIRE

    Dr. S. T. Waghmode

    2012-01-01

    Research is the most distinguished activity that enhances the quality of higher-education. A person obsessed with research has to face many problems. Apart from having an appropriate guide, the real problem begins with the selection of the research topic. The vast and gleaming research area is always changing its dimensions. Some well-set, readymade and stereotyped topics do not attract the attention of a competent researcher, because he or she is always looking for what is new and qualitativ...

  11. Frostbites in circumpolar areas

    Directory of Open Access Journals (Sweden)

    Tiina Maria Ikäheimo

    2011-10-01

    Full Text Available Circumpolar areas are associated with prolonged cold exposure where wind, precipitation, and darkness further aggravate the environmental conditions and the associated risks. Despite the climate warming, cold climatic conditions will prevail in circumpolar areas and contribute to adverse health effects. Frostbite is a freezing injury where localized damage affects the skin and other tissues. It occurs during occupational or leisure-time activities and is common in the general population among men and women of various ages. Industries of the circumpolar areas where frostbite occurs frequently include transportation, mining, oil, and gas industry, construction, agriculture, and military operations. Cold injuries may also occur during leisure-time activities involving substantial cold exposure, such as mountaineering, skiing, and snowmobiling. Accidental situations (occupational, leisure time often contribute to adverse cooling and cold injuries. Several environmental (temperature, wind, wetness, cold objects, and altitude and individual (behavior, health, and physiology predisposing factors are connected with frostbite injuries. Vulnerable populations include those having a chronic disease (cardiovascular, diabetes, and depression, children and the elderly, or homeless people. Frostbite results in sequelae causing different types of discomfort and functional limitations that may persist for years. A frostbite injury is preventable, and hence, unacceptable from a public health perspective. Appropriate cold risk management includes awareness of the adverse effects of cold, individual adjustment of cold exposure and clothing, or in occupational context different organizational and technical measures. In addition, vulnerable population groups need customized information and care for proper prevention of frostbites.

  12. Neural mediators of the intergenerational transmission of family aggression.

    Science.gov (United States)

    Saxbe, Darby; Del Piero, Larissa Borofsky; Immordino-Yang, Mary Helen; Kaplan, Jonas Todd; Margolin, Gayla

    2016-05-01

    Youth exposed to family aggression may become more aggressive themselves, but the mechanisms of intergenerational transmission are understudied. In a longitudinal study, we found that adolescents' reduced neural activation when rating their parents' emotions, assessed via magnetic resonance imaging, mediated the association between parents' past aggression and adolescents' subsequent aggressive behavior toward parents. A subsample of 21 youth, drawn from the larger study, underwent magnetic resonance imaging scanning proximate to the second of two assessments of the family environment. At Time 1 (when youth were on average 15.51 years old) we measured parents' aggressive marital and parent-child conflict behaviors, and at Time 2 (≈2 years later), we measured youth aggression directed toward parents. Youth from more aggressive families showed relatively less activation to parent stimuli in brain areas associated with salience and socioemotional processing, including the insula and limbic structures. Activation patterns in these same areas were also associated with youths' subsequent parent-directed aggression. The association between parents' aggression and youths' subsequent parent-directed aggression was statistically mediated by signal change coefficients in the insula, right amygdala, thalamus, and putamen. These signal change coefficients were also positively associated with scores on a mentalizing measure. Hypoarousal of the emotional brain to family stimuli may support the intergenerational transmission of family aggression.

  13. 76 FR 19310 - Information Collection; Certified State Mediation Program

    Science.gov (United States)

    2011-04-07

    ... Farm Service Agency Information Collection; Certified State Mediation Program AGENCY: Farm Service... Mediation Program. The information collection is necessary to ensure the grant program is being administered... following methods: Mail: Carol Wagner, Certified State Mediation Program Manager, USDA, FSA, Appeals...

  14. Current rectification by mediating electroactive polymers

    Energy Technology Data Exchange (ETDEWEB)

    Ybarra, Gabriel; Moina, Carlos [Centro de Investigacion sobre Electrodeposicion y Procesos Superficiales, Instituto Nacional de Tecnologia Industrial, CC 157, (1650) San Martin (Argentina); Florit, M. Ines [INIFTA, Facultad de Ciencias Exactas, UNLP, Suc. 4, CC 16, (1900) La Plata (Argentina); Posadas, Dionisio [INIFTA, Facultad de Ciencias Exactas, UNLP, Suc. 4, CC 16, (1900) La Plata (Argentina)], E-mail: dposadas@inifta.unlp.edu.ar

    2008-04-20

    In this work we briefly review the theoretical basis for the electrochemical rectification in mediated redox reactions at redox polymer modified electrodes. Electrochemical rectification may have two distinct origins. It is either caused by a slow kinetics of the reaction between the external redox couple and the mediator or it is originated by a slow electronic transport within the film under an unfavorable thermodynamic condition. We show experimental results for the redox mediation reaction of poly(o-aminophenol) (POAP) on the Fe{sup 2+/3+} and on the Fe(CN){sub 6}{sup 3-/4-} redox couples in solution that prove the proposed mechanisms of electrochemical rectification.

  15. Gauge - Mediated Supersymmetry Breaking in String Compactifications

    Energy Technology Data Exchange (ETDEWEB)

    Diaconescu, Duiliu-Emanuel; /Rutgers U., Piscataway; Florea, Bogdan; Kachru, Shamit; Svrcek, Peter; /Stanford U., Phys. Dept. /SLAC

    2006-01-04

    We provide string theory examples where a toy model of a SUSY GUT or the MSSM is embedded in a compactification along with a gauge sector which dynamically breaks supersymmetry. We argue that by changing microscopic details of the model (such as precise choices of flux), one can arrange for the dominant mediation mechanism transmitting SUSY breaking to the Standard Model to be either gravity mediation or gauge mediation. Systematic improvement of such examples may lead to top-down models incorporating a solution to the SUSY flavor problem.

  16. [Role of internal mediators in surgical stress].

    Science.gov (United States)

    Endo, Shigeatsu; Sato, Nobuhiro

    2003-12-01

    In surgical stress, internal mediators include cytokines released locally as well as into the circulation; activation of neutrophils, monocytes, macrophages, endothelial cells, platelets and other cells; activation of plasma protein cascade systems such the complement, coagulation, fibrinolytic and contact systems the release of tissue-damaging proteinases; the formation of lipid mediators such as eicosanoids and platelet-activating factor; and the generation of oxygen and nitrogen radicals. In addition, during host defense rections, a number of agents are released that blunt the inflammatory response, such as anti-inflamatory cytokines, soluble cytokine receptors, acute-phase proteins including proteinase inhibitors and stress hormones. In this paper, we explain such internal mediators.

  17. Singlet deflected anomaly/gauge mediation

    International Nuclear Information System (INIS)

    We study an extension of the standard anomaly/gauge mediation scenario where the messenger fields have direct interactions with an extra gauge singlet. This realizes a phenomenologically viable NMSSM-like scenario free of the μ-bμ problem. Current cosmological constraints imply a small size for the anomaly-mediation contributions, unless some source of R-parity violation is permitted. In the latter case the allowed regions in the parameter space can be substantially larger than in the corresponding gauge-mediation scenario.

  18. Hybrid anomaly-gravity mediation with flavor

    International Nuclear Information System (INIS)

    We study models with contributions of similar size to the soft masses from anomaly-and gravity mediation, thereby curing the tachyonic slepton problem of anomaly mediation. A possible origin of this hybrid setup in a 5-dimensional brane world is briefly discussed. The absence of excessive flavor violation is explained by alignment. The gravitino can be heavy enough so that the gravitino problem of supersymmetric theories with leptogenesis is avoided. The model has a characteristic signature: It predicts the distinctive gaugino mass pattern of anomaly mediation and, at the same time, O(1) slepton mass splittings.

  19. Politics by means other than war : understanding international mediation

    OpenAIRE

    Beardsley, Kyle C.

    2006-01-01

    A series of specific choices, made by both the antagonists in a conflict and the third parties that mediate, determine the distribution of mediation resources. These choices, which include the selection of whether to have mediation, the choice of who mediates, and the adoption of particular mediator strategies, ultimately affect the prospects for successful outcomes. Studying the mediation selection process has two primary purposes. First, it prevents misleading inferences caused by the invol...

  20. REGULATION OF INSURANCE MEDIATION IN CONDITIONS OF EURO INTEGRATION PROCESSES OF UKRAINE

    Directory of Open Access Journals (Sweden)

    A. Sholoiko

    2016-03-01

    Full Text Available The review of national and European legislation in the field of regulation of insurance mediation is made. Subjects and object of regulation of insurance mediation are defined. The order of the legislative approximation in conditions of changing legislation of regulation of insurance mediation in European Union is characterized. A comparison of legal provisions to regulate insurance mediation in Ukraine and the EU is done. Suggestions of adaptation national legislation to the European in the area of regulation of insurance mediation in conditions of euro integration processes are represented. The main are the next:-it is advisable to expand the object and the scope of regulation of insurance mediation and set appropriate limits to the subjects for which the sale of insurance products is not the main activity;-it is necessary to introduce a regular improvement of the knowledge and skills for insurance distributors because of the development of insurance conditions and changing of economic environment;-it is necessary to create the order of compulsory professional indemnity insurance in accordance with the requirements of the Directive on insurance distribution;-before the signing of the contract it is necessary to disclosure to customers of insurance products the information about the status of insurance distributors and type of remuneration that they receive;-if the insurance product is in addition to the goods or services, insurance distributor shall inform the client about the possibility of buying various product components separately with the presentation of their characteristics.

  1. REGULATION OF INSURANCE MEDIATION IN CONDITIONS OF EURO INTEGRATION PROCESSES OF UKRAINE

    Directory of Open Access Journals (Sweden)

    A. Sholoiko

    2016-05-01

    Full Text Available The review of national and European legislation in the field of regulation of insurance mediation is made. Subjects and object of regulation of insurance mediation are defined. The order of the legislative approximation in conditions of changing legislation of regulation of insurance mediation in European Union is characterized. A comparison of legal provisions to regulate insurance mediation in Ukraine and the EU is done. Suggestions of adaptation national legislation to the European in the area of regulation of insurance mediation in conditions of euro integration processes are represented. The main are the next: - it is advisable to expand the object and the scope of regulation of insurance mediation and set appropriate limits to the subjects for which the sale of insurance products is not the main activity; - it is necessary to introduce a regular improvement of the knowledge and skills for insurance distributors because of the development of insurance conditions and changing of economic environment; - it is necessary to create the order of compulsory professional indemnity insurance in accordance with the requirements of the Directive on insurance distribution; - before the signing of the contract it is necessary to disclosure to customers of insurance products the information about the status of insurance distributors and type of remuneration that they receive; - if the insurance product is in addition to the goods or services, insurance distributor shall inform the client about the possibility of buying various product components separately with the presentation of their characteristics.

  2. Child custody mediation and litigation: custody, contact, and coparenting 12 years after initial dispute resolution.

    Science.gov (United States)

    Emery, R E; Laumann-Billings, L; Waldron, M C; Sbarra, D A; Dillon, P

    2001-04-01

    Long-term follow-up data were obtained on families who had been randomly assigned to mediate or litigate their child custody disputes. In comparison with families who litigated custody, nonresidential parents who mediated were more involved in multiple areas of their children's lives, maintained more contact with their children, and had a greater influence in coparenting 12 years after the resolution of their custody disputes. The increased involvement of nonresidential parents who mediated did not lead to an associated increase in coparenting conflict. Parents who mediated also made more changes in their children's living arrangements over the years. For the most part, the changes apparently reflect increased cooperation and flexibility. Satisfaction declined for parents (especially fathers) in both groups over time, but fathers remained much more satisfied if they mediated rather than litigated custody. Few differences in satisfaction were found between mothers in the 2 groups. The 12-year follow-up data indicate that, even in contested cases. mediation encourages both parents to remain involved in their children's lives after divorce without increasing coparenting conflict.

  3. CELLULAR INTERACTIONS MEDIATED BY GLYCONECTIDS

    Directory of Open Access Journals (Sweden)

    O.Popescu

    1999-01-01

    Full Text Available Cellular interactions involve many types of cell surface molecules and operate via homophilic and/or heterophilic protein-protein and protein-carbohydrate binding. Our investigations in different model-systems (marine invertebrates and mammals have provided direct evidence that a novel class of primordial proteoglycans, named by us gliconectins, can mediate cell adhesion via a new alternative molecular mechanism of polyvalent carbohydrate-carbohydrate binding. Biochemical characterization of isolated and purified glyconectins revealed the presence of specific carbohydrate structures, acidic glycans, different from classical glycosaminoglycans. Such acidic glycans of high molecular weight containing fucose, glucuronic or galacturonic acids, and sulfate groups, originally found in sponges and sea urchin embryos, may represent a new class of carbohydrate carcino-embryonal antigens in mice and humans. Such interactions between biological macromolecules are usually investigated by kinetic binding studies, calorimetric methods, X-ray diffraction, nuclear magnetic resonance, and other spectroscopic analyses. However, these methods do not supply a direct estimation of the intermolecular binding forces that are fundamental for the function of the ligand-receptor association. Recently, we have introduced atomic force microscopy to quantify the binding strength between cell adhesion proteoglycans. Measurement of binding forces intrinsic to cell adhesion proteoglycans is necessary to assess their contribution to the maintenance of the anatomical integrity of multicellular organisms. As a model, we selected the glyconectin 1, a cell adhesion proteoglycan isolated from the marine sponge Microciona prolifera. This glyconectin mediates in vivo cell recognition and aggregation via homophilic, species-specific, polyvalent, and calcium ion-dependent carbohydrate-carbohydrate interactions. Under physiological conditions, an adhesive force of up to 400 piconewtons

  4. Electroporation-mediated gene delivery.

    Science.gov (United States)

    Young, Jennifer L; Dean, David A

    2015-01-01

    Electroporation has been used extensively to transfer DNA to bacteria, yeast, and mammalian cells in culture for the past 30 years. Over this time, numerous advances have been made, from using fields to facilitate cell fusion, delivery of chemotherapeutic drugs to cells and tissues, and most importantly, gene and drug delivery in living tissues from rodents to man. Electroporation uses electrical fields to transiently destabilize the membrane allowing the entry of normally impermeable macromolecules into the cytoplasm. Surprisingly, at the appropriate field strengths, the application of these fields to tissues results in little, if any, damage or trauma. Indeed, electroporation has even been used successfully in human trials for gene delivery for the treatment of tumors and for vaccine development. Electroporation can lead to between 100 and 1000-fold increases in gene delivery and expression and can also increase both the distribution of cells taking up and expressing the DNA as well as the absolute amount of gene product per cell (likely due to increased delivery of plasmids into each cell). Effective electroporation depends on electric field parameters, electrode design, the tissues and cells being targeted, and the plasmids that are being transferred themselves. Most importantly, there is no single combination of these variables that leads to greatest efficacy in every situation; optimization is required in every new setting. Electroporation-mediated in vivo gene delivery has proven highly effective in vaccine production, transgene expression, enzyme replacement, and control of a variety of cancers. Almost any tissue can be targeted with electroporation, including muscle, skin, heart, liver, lung, and vasculature. This chapter will provide an overview of the theory of electroporation for the delivery of DNA both in individual cells and in tissues and its application for in vivo gene delivery in a number of animal models.

  5. Selective Area Band Engineering of Graphene using Cobalt-Mediated Oxidation

    OpenAIRE

    Paul F. Bazylewski; Luan Nguyen; Robert P.C. Bauer; Hunt, Adrian H.; Eamon J. G. McDermott; Leedahl, Brett D.; Andrey I. Kukharenko; Cholakh, Seif O.; Kurmaev, Ernst Z.; Peter Blaha; Alexander Moewes; Young Hee Lee; Gap Soo Chang

    2015-01-01

    This study reports a scalable and economical method to open a band gap in single layer graphene by deposition of cobalt metal on its surface using physical vapor deposition in high vacuum. At low cobalt thickness, clusters form at impurity sites on the graphene without etching or damaging the graphene. When exposed to oxygen at room temperature, oxygen functional groups form in proportion to the cobalt thickness that modify the graphene band structure. Cobalt/Graphene resulting from this trea...

  6. Small Area Fair Market Rent

    Data.gov (United States)

    Department of Housing and Urban Development — Due to the increasing demand for more localized rents for a variety of purposes, HUD is making Small Area FMRs for all metropolitan areas available. Small Area FMRs...

  7. A school peer mediation program as a context for exploring therapeutic jurisprudence (TJ): Can a peer mediation program inform the law?

    Science.gov (United States)

    McWilliam, Nicky

    2010-01-01

    This paper reports an exploratory study of a school peer mediation program implemented as an alternative way to manage bullying and other destructive conflict. The study explores the effects of the program on the well-being of members of the school community by examining perceptions of students, staff and a sample of parents and former students. Drawing on therapeutic jurisprudence (TJ) the study explores whether the component parts of the program, separately or together, promote intended or unintended therapeutic effects. The preliminary findings of the study emphasise the importance of peer mediation training and suggest that existing scholarship in the area of school conflict resolution and peer mediation, when viewed through a TJ lens, may provide valuable insights into how to optimally configure programs for development and adoption in schools and other community settings. The study highlights the lack of attention paid by the legal system to valuable scholarship in the area of school conflict resolution and peer mediation, which may have implications for the understanding and development of legal processes and the law in general.

  8. Dementia in Taiwan area

    Institute of Scientific and Technical Information of China (English)

    Yuanhan Yang

    2016-01-01

    Objective:Taiwan has an increasing aging population like other developed areas. The aging population will lead to an increased prevalence of dementia. Methods:This article will reflect the status of dementia in Taiwan, including updated epidemiology, diagnosis, subtypes, and optimal treatment of dementia. Results:The article also describes and interprets the Taiwan Dementia Policy to establish a clear, large view of the current state of management of dementia in Taiwan and future policy implementation. Conclusion:A comprehensive policy to dementia, from the basic researches to clinical care and treatment, is necessary to the increased aged population in Taiwan.

  9. Large area bulk superconductors

    Science.gov (United States)

    Miller, Dean J.; Field, Michael B.

    2002-01-01

    A bulk superconductor having a thickness of not less than about 100 microns is carried by a polycrystalline textured substrate having misorientation angles at the surface thereof not greater than about 15.degree.; the bulk superconductor may have a thickness of not less than about 100 microns and a surface area of not less than about 50 cm.sup.2. The textured substrate may have a thickness not less than about 10 microns and misorientation angles at the surface thereof not greater than about 15.degree.. Also disclosed is a process of manufacturing the bulk superconductor and the polycrystalline biaxially textured substrate material.

  10. 7 CFR 205.663 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative Compliance § 205.663 Mediation. Any dispute with...

  11. Molecular biology Mediating transcription and RNA export

    Science.gov (United States)

    Rubin, Jonathan D.; Taatjes, Dylan J.

    2016-01-01

    The finding that the Mediator protein complex contributes to messenger RNA export from the nucleus in yeast adds to a growing list of roles for the complex in regulating transcriptional processes. PMID:26450052

  12. Genesis and intersubjectivity: levels of mediation.

    Science.gov (United States)

    Yamamoto, Toshiya

    2012-09-01

    I will make a brief comment on the thesis of José C. Loredo-Narciandi and José C. Sánchez-González (2012) "Neither Dichotomies Nor Dualism; Simply Genesis". Denying any reductionism and reification, they insists the importance of inseparable relation between subject and object, then discuss about genesis. I pointed out that their argument lacks an important element, i.e., mediator that differ from mere physical object. After discussing mediators nature, I discriminate the three level of interaction which mediated by mediator. The first is the pre-interaction level, the second is physical interaction level and the third is sign or language interaction level. The last argument of mine is about how we can solve the problem of reification and reductionism. In the argument it is pointed out that intersubjectivity is key concept for understanding and solving the problem appropriately.

  13. Cybercultures mediations of community, culture, politics

    CERN Document Server

    Harris, Breslow

    2012-01-01

    Cybercultures: Mediations of Community, Culture, Politics , is a collection of essays that critically examine the role that digital media and online cultures play in the rearticulation of contemporary societies, cultures and polities. This volume in

  14. BRIEF CONSIDERATIONS REGARDING MEDIATION IN CRIMINAL MATTERS

    Directory of Open Access Journals (Sweden)

    LUMINITA DRAGNE

    2012-05-01

    Full Text Available Mediation is an alternative means of conflict resolution, is designed as a flexible procedure whose utility was observed in contrast to the deficiencies of the judiciary system. In the field of criminal law, mediation is part of the larger concept of the restorative justice whose aim is restoring the main victim in its rights. From this perspective, to the criminal process is intended, in principal, repairing of the victim's prejudice and, subsequently, to encourage the delinquent in taking responsibility and to acknowledge his guilt, and also to determine him to actively participate in repairing the damage caused. The ultimate goal of the process is giving back the delinquent to society and consequently, reducing the relapse. Romanian legislator has not taken this concept, and how it is regulated mediation in criminal matters is hesitant, cautious and ultimately ineffective. Specifically, in situations that will actually occur, victim-delinquent mediation will only take the form of "assisted reconciliation."

  15. Upscaling of Bio-mediated Soil Improvement

    Energy Technology Data Exchange (ETDEWEB)

    J. T. DeJong; B. C. Martinez; B. M. Mortensen; D. C. Nelson; J. T. Waller; M. H. Weil; T. R. Ginn; T. Weathers; T. Barkouki; Y. Fujita; G. Redden; C. Hunt; D. Major; B. Tunyu

    2009-10-01

    As demand for soil improvement continues to increase, new, sustainable, and innocuous methods are needed to alter the mechanical properties of soils. Recent research has demonstrated the potential of bio-mediated soil improvement for geotechnical applications (DeJong et al. 2006, Whiffin et al. 2007). Upscaling the bio-mediated treatment process for in situ implementation presents a number of challenges to be addressed, including soil and pore fluid interactions, bioaugmentation versus biostimulation of microbial communities, controlled distribution of mediated calcite precipitation, and permanence of the cementation. Current studies are utilizing large-scale laboratory experiments, non-destructive geophysical measurements, and modeling, to develop an optimized and predictable bio-mediated treatment method.

  16. Dark matter prospects in deflected mirage mediation

    International Nuclear Information System (INIS)

    The recently introduced deflected mirage mediation (DMM) model is a string-motivated paradigm in which all three of the major supersymmetry-breaking transmission mechanisms are operative. We begin a systematic exploration of the parameter space of this rich model context, paying special attention to the pattern of gaugino masses which arise. In this work we focus on the dark matter phenomenology of the DMM model as such signals are the least influenced by the model-dependent scalar masses. We find that a large portion of the parameter space in which the three mediation mechanisms have a similar effective mass scale of 1 TeV or less will be probed by future direct and indirect detection experiments. Distinguishing deflected mirage mediation from the mirage model without gauge mediation will prove difficult without collider input, though we indicate how gamma ray signals may provide an opportunity for distinguishing between the two paradigms

  17. Programmable DNA-mediated multitasking processor

    CERN Document Server

    Shu, Jian-Jun; Yong, Kian-Yan; Shao, Fangwei; Lee, Kee Jin

    2015-01-01

    Because of DNA appealing features as perfect material, including minuscule size, defined structural repeat and rigidity, programmable DNA-mediated processing is a promising computing paradigm, which employs DNAs as information storing and processing substrates to tackle the computational problems. The massive parallelism of DNA hybridization exhibits transcendent potential to improve multitasking capabilities and yield a tremendous speed-up over the conventional electronic processors with stepwise signal cascade. As an example of multitasking capability, we present an in vitro programmable DNA-mediated optimal route planning processor as a functional unit embedded in contemporary navigation systems. The novel programmable DNA-mediated processor has several advantages over the existing silicon-mediated methods, such as conducting massive data storage and simultaneous processing via much fewer materials than conventional silicon devices.

  18. Yeast Oligo-mediated Genome Engineering (YOGE)

    OpenAIRE

    DiCarlo, JE; Conley, AJ; Penttilä, M; Jäntti, J; Wang, HH; Church, GM

    2013-01-01

    High-frequency oligonucleotide-directed recombination engineering (recombineering) has enabled rapid modification of several prokaryotic genomes to date. Here, we present a method for oligonucleotide-mediated recombineering in the model eukaryote and industrial production host S. cerevisiae, which we call Yeast Oligo-mediated Genome Engineering (YOGE). Through a combination of overexpression and knockouts of relevant genes and optimization of transformation and oligonucleotide designs, we ach...

  19. Mediated and Mobile Communication for Experts

    OpenAIRE

    Nilsson, Marcus

    2014-01-01

    This thesis focuses on systems for mediated communication that run on mobile technology. The aim has been to give an answer to the question about what require- ments there are for situation awareness for domain experts when communication is secondary and supports the primary task. This thesis originated in a critical approach to the common practice of design- ing mediated communication systems with the face-to-face meeting as a guiding scenario. Instead, this thesis explores a design process ...

  20. Mediated Certificateless Signature without Random Oracles

    Directory of Open Access Journals (Sweden)

    Minghui Zheng

    2011-08-01

    Full Text Available It is worthwhile challenges to deal with the key escrow problem and key revocation in identity-based signatures. We first introduce the notion of security-mediated certificateless signature scheme and proves the scheme in the standard model. The mediated certificateless public key cryptography not only provides a fast revocation with fine granularity but also overcomes the key escrow property which exists in ID-based signature. The scheme is provably secure without random oracles.

  1. The Mediation of Power: A Criticial Introduction

    OpenAIRE

    Davis, Aeron

    2007-01-01

    The Mediation of Power investigates how those in positions of power use and are influenced by media in their everyday activities. Each chapter examines this theme through an exploration of some of the key topics and debates in the field, including theories of media and power, media policy and the economics of information, news production and journalistic practice, public relations and media management, culture and power, political communication and mediated politics, new and alternative media...

  2. Immunogenetic markers in immune mediated diseases

    OpenAIRE

    Nikitina-Zake, Liene

    2003-01-01

    The aim of this thesis was to study HLA class II markers, as well as other - MHC and non MHC genes in different immune - mediated diseases, namely, cervical intraepithelial neoplasia (CIN), cervical cancer, juvenile idiopathic arthritis (JIA), mixed connective tissue disease (MCTD) and type I diabetes mellitus (T1 DM). HLA class II genes are located on the short arm of chromosome 6 and are known to be important for pathogenesis of immune - mediated diseases due to the fu...

  3. Community mediation and social harmony in Nepal

    OpenAIRE

    Stein, Danielle

    2013-01-01

    This paper is part of the Theories in Practice series arising from the collaboration between JSRP and The Asia Foundation. The paper explores The Asia Foundation’s ‘Theory of Change’ for community mediation in Nepal. Through analysis of academic and practitioner sources combined with primary research across six Nepali districts, this paper analyses the evidence supporting the claim that mediation ‘improves social harmony’. This analysis is conducted using a framework of three potential path...

  4. Nordic Mediation - Comparing Denmark and Finland

    DEFF Research Database (Denmark)

    Lappi-Seppälä, Tapio; Storgaard, Anette

    2015-01-01

    The Nordic Countries have a long common history in criminal policy but a closer look also indicates individual Development. the introduction of Victim Offender Mediation is one example of Nordic diversity in details.......The Nordic Countries have a long common history in criminal policy but a closer look also indicates individual Development. the introduction of Victim Offender Mediation is one example of Nordic diversity in details....

  5. Developing the conversation about workplace mediation

    OpenAIRE

    Kenny, Teresa

    2014-01-01

    This article examines some of the latest writing and research in relation to conflict in work and workplace mediation. It considers three specific issues of size and sector of organisations, the attitude of organisations to conflict and the employee relations environment in organisations. It reviews the various views in relation to fundamental aspects of mediation such as the neutral third party, voluntarism, informality and confidentiality to inform thinking as well as practitioner and acade...

  6. Mechanisms mediating cholinergic antral circular smooth muscle contraction in rats

    Institute of Scientific and Technical Information of China (English)

    Helena F Wrzos; Tarun Tandon; Ann Ouyang

    2004-01-01

    AIM: To investigate the pathway (s) mediating rat antral circular smooth muscle contractile responses to the cholinomimetic agent, bethanechol and the subtypes of muscarinic receptors mediating the cholinergic contraction.METHODS: Circular smooth muscle strips from the antrum of Sprague-Dawley rats were mounted in muscle baths in Krebs buffer. Isometric tension was recorded. Cumulative concentration-response curves were obtained for (+)-cisdioxolane (cD), a nonspecific muscarinic agonist, at 10-8-10-4 mol/L, in the presence of tetrodotoxin (TTX, 10-7 mol/L).Results were normalized to cross sectional area. A repeat concentration-response curve was obtained after incubation of the muscle for 90 min with antagonists for M1 (pirenzepine),M2 (methoctramine) and M3 (darifenacin) muscarinic receptor subtypes. The sensitivity to PTX was tested by the ip injection of 100 mg/kg of PTX 5 d before the experiment. The antral circular smooth muscles were removed from PTX-treated and non-treated rats as strips and dispersed smooth muscle cells to identify whether PTX-linked pathway mediated the contractility to bethanechol.RESULTS: A dose-dependent contractile response observed with bethanechol, was not affected by TTX. The pretreatment of rats with pertussis toxin decreased the contraction induced by bethanechol. Lack of calcium as Well as the presence of the L-type calcium channel blocker, nifedipine, also inhibited the cholinergic contraction, with a reduction in response from 2.5±0.4 g/mm2 to 1.2±0.4 g/mm2 (P<0.05). The doseresponse curves were shifted to the right by muscarinic antagonists in the following order of affinity: darifenacin(M3)>methocramine (M2)>pirenzepine (M1).CONCLUSION: The muscarinic receptors-dependent contraction of rat antral circular smooth muscles was linked to the signal transduction pathway(s) involving pertussis-toxin sensitive GTP-binding proteins and to extracellular calcium via L-type voltage gated calcium channels. The presence of the

  7. Ombuds’ corner: Consider mediation - some rules

    CERN Multimedia

    Vincent Vuillemin

    2013-01-01

    Mediation is a structured process in which an external party, called a mediator, helps participants generate and evaluate options that would allow them to reach a mutual agreement. It is an informal and confidential process.   The mediator does not have the power to impose an agreement on the parties, who should find it by themselves. However, the mediator controls the process. He arranges the meetings in agreement with the parties, and coordinates the details (concerning the speaking times, for example) and ensures that the parties respect of the rules which have been agreed on. He also favours advancing of the process towards a solution. The mediation process is centred on the search for a solution and a mutual agreement. In such a process, the mediator takes a neutral and impartial position, and does not advocate for a single party. He favours good communication between the parties, and will ensure that mutual respect is maintained and that the correct language is used during the discussi...

  8. Flavorful hybrid anomaly-gravity mediation

    International Nuclear Information System (INIS)

    We consider supersymmetric models where anomaly and gravity mediation give comparable contributions to the soft terms and discuss how this can be realized in a five-dimensional brane world. The gaugino mass pattern of anomaly mediation is preserved in such a hybrid setup. The flavorful gravity-mediated contribution cures the tachyonic slepton problem of anomaly mediation. The supersymmetric flavor puzzle is solved by alignment. We explicitly show how a working flavor-tachyon link can be realized with Abelian flavor symmetries and give the characteristic signatures of the framework, including O(1) slepton mass splittings between different generations and between doublets and singlets. This provides opportunities for same flavor dilepton edge measurements with missing energy at the Large Hadron Collider (LHC). Rare lepton decay rates could be close to their current experimental limit. Compared to pure gravity mediation, the hybrid model is advantageous because it features a heavy gravitino which can avoid the cosmological gravitino problem of gravity-mediated models combined with leptogenesis.

  9. The jurisprudence of responsive mediation: An empirical examination of Chinese people's mediation in action

    OpenAIRE

    Ali, S

    2013-01-01

    Community mediation in China has a long history and finds its roots in both cultural (traditional Confucian ideologies) and functional (the avoidance of social conflicts) aims. Recently, however, owing to changes in societal values occurring alongside China’s economic open-door policy, traditional values are losing their prominent role in the mediation process. Meanwhile, reforms are being carried out to provide greater structure to community mediation in China. The combination of these chang...

  10. Dispute Settlement through Banking Mediation

    Directory of Open Access Journals (Sweden)

    Angelica ROSU

    2010-11-01

    earlier legislation and the current legislation, the Emergency Ordinance no. 113/2009, this document proposing the establishment of a specialized department that is responsible with the resolution of disputes between consumers and financial service providers ofbanking and insurance. However, although in 2004 we have legislation that enables the implementation of mediation as a means of dispute settlement in the banking sector (Government Ordinance. 6 / 2004, the practical delays occur.

  11. Gazetteer Brokering through Semantic Mediation

    Science.gov (United States)

    Hobona, G.; Bermudez, L. E.; Brackin, R.

    2013-12-01

    web technologies, including ontologies and a semantic mediator. The semantically-enhanced SPEGG allowed a client to submit a single query (e.g. ';hills') and to retrieve data from two separate gazetteers with different vocabularies (e.g. where one refers to ';summits' another refers to ';hills'). Supporting the SPEGG was a SPARQL server that held the ontologies and processed queries on them. Earth Science surveys and forecast always have a place on Earth. Being able to share the information about a place and solve inconsistencies about that place from different sources will enable geoscientists to better do their research. In the advent of mobile geo computing and location based services (LBS), brokering gazetteers will provide geoscientists with access to gazetteer services rich with information and functionality beyond that offered by current generic gazetteers.

  12. Wide area sensor network

    Science.gov (United States)

    Mukhopadhyay, Sanjoy; Nix, Tricia; Junker, Robert; Brentano, Josef; Khona, Dhiren

    2006-05-01

    The technical concept for this project has existed since the Chernobyl accident in 1986. A host of Eastern European nations have developed countrywide grid of sensors to monitor airborne radiation. The objective is to build a radiological sensor network for real-time monitoring of environmental radiation levels in order to provide data for warning, and consequentially the assessment of a nuclear event. A network of radiation measuring equipment consisting of gamma, neutron, alpha, and beta counters would be distributed over a large area (preferably on fire station roof tops) and connected by a wireless network to the emergency response center. The networks would be deployed in urban environments and would supply first responders and federal augmentation teams (including those from the U.S. Departments of Energy, Defense, Justice, and Homeland Security) with detailed, accurate information regarding the transport of radioactive environmental contaminants, so the agencies can provide a safe and effective response. A networked sensor capability would be developed, with fixed sensors deployed at key locations and in sufficient numbers, to provide adequate coverage for early warning, and input to post-event emergency response. An overall system description and specification will be provided, including detector characteristics, communication protocols, infrastructure and maintenance requirements, and operation procedures. The system/network can be designed for a specifically identified urban area, or for a general urban area scalable to cities of specified size. Data collected via the network will be transmitted directly to the appropriate emergency response center and shared with multiple agencies via the Internet or an Intranet. The data collected will be managed using commercial off - the - shelf Geographical Information System (GIS). The data will be stored in a database and the GIS software will aid in analysis and management of the data. Unique features of the

  13. Local area networks

    CERN Document Server

    Zafiropoulo, P

    1982-01-01

    Pitro Zafiropulo is a- staff member at the IBM Research Laboratories at Zurich. He joined IBM in 1968 and has worked on protocol validation, synthesis, integrated networks, network reliability, PABX's and speech recognition. Local Area Networks are intended to provide improved communication capabilities such as high data throughput rates, low error rates and ease of connection among terminal stations and comuters. These new types of networks operate within a limited geographical range like an establishment, campus or building and are owned by a single organization. The presentation introduces these networks and the main techniques are described. It then proceeds to evaluate the main switching techniques as they apply to LAN ring and bus configurations. The preferred technique of token-ring distributed switching is identified. The contents of Mr. Zafiropoulo's talk was somewhat similar to the paper of Mr. Kummerle, which is therefore included in these Proceedings.

  14. Phoenix Work Area Animation

    Science.gov (United States)

    2008-01-01

    [figure removed for brevity, see original site] Click on image for animation This animation from Sol 1 shows a mosaic of the Phoenix digging area in the Martian terrain. Phoenix scientists are very pleased with this view as the terrain features few rocks an optimal place for digging. The mast of the camera looks disjointed because the photos that comprise this mosaic were taken at different times of day. This video also show some of the lander's instrumentation. The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

  15. Say it with flowers! An fMRI study of object mediated communication

    DEFF Research Database (Denmark)

    Tylén, Kristian; Wallentin, Mikkel; Roepstorff, Andreas

    2009-01-01

    -related fMRI to study the brain activity caused by everyday material objects when they are perceived as signals. We found that comprehension of material signals activates bilaterally areas of the ventral stream and pars triangularis of the inferior frontal cortex, that is, areas traditionally associated...... with verbal language and semantics. In addition, we found that right-hemisphere inferior frontal cortex is recruited as a function of the increasing unconventionality of communicative objects. Together these findings support an interpretation of the traditional language areas as playing a more general role...... across modalities in relation to communicational mediation of social semantic meaning....

  16. Organizational mediators siding with or against the powerful party

    NARCIS (Netherlands)

    Laskewitz, P; Van de Vliert, E; De Dreu, C K W

    1994-01-01

    Instead of being impartial, a mediator may side with one party as a function of the disputants' power differences, the mediator's legitimacy judgments, or the disputants' capacity to sanction the mediator. According to the power balancing theory, a mediator sides with the party that has a power disa

  17. Construction of Mediators for Heterogeneous Data Source Integration Systems

    Institute of Scientific and Technical Information of China (English)

    高明; 宋瀚涛

    2003-01-01

    To construct mediators for data integration systems that integrate structured and semi-structured data, and to facilitate the reformulation and decomposition of the query, the presented system uses the XML processing language (XPL) for the mediator. With XPL, it is easy to construct mediators for data integration based on XML, and it can accelerate the work in the mediator.

  18. Surveying Parental Mediation: Connections, Challenges and Questions for Media Literacy

    Science.gov (United States)

    Mendoza, Kelly

    2009-01-01

    This paper examines three strategies of parental mediation--coviewing, restrictive mediation, and active mediation--in order to make connections, challenge, and raise questions for media literacy. Coviewing, whether it is intentional practice, or whether it functions to promote media literacy, is explored. Restrictive mediation, how it connects to…

  19. The Peacekeepers: Students Use Mediation Skills to Resolve Conflicts.

    Science.gov (United States)

    Meek, Michael

    1992-01-01

    Examines the use of mediation skills in elementary and secondary education. Discusses the rise in school violence; and describes mediation techniques, the rationale for their use, school programs to introduce mediation, peer mediators, and long-term benefits to students and the school community. Offers resources. (JB)

  20. A State Space Modeling Approach to Mediation Analysis

    Science.gov (United States)

    Gu, Fei; Preacher, Kristopher J.; Ferrer, Emilio

    2014-01-01

    Mediation is a causal process that evolves over time. Thus, a study of mediation requires data collected throughout the process. However, most applications of mediation analysis use cross-sectional rather than longitudinal data. Another implicit assumption commonly made in longitudinal designs for mediation analysis is that the same mediation…

  1. 15 CFR 923.83 - Mediation of amendments.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Mediation of amendments. 923.83... Programs § 923.83 Mediation of amendments. (a) Section 307(h)(2) of the Act provides for mediation of... management program. Accordingly mediation is available to states or federal agencies when a...

  2. Reducing Levels of Elementary School Violence with Peer Mediation

    Science.gov (United States)

    Schellenberg, Rita Cantrell; Parks-Savage, Agatha; Rehfuss, Mark

    2007-01-01

    The effectiveness of an existing peer mediation program in a diverse, suburban elementary school was examined. Peer mediation was available to all students (N = 825). Three-year longitudinal data showed significant reductions in the school's out-of-school suspensions after implementation of the peer mediation program. Mediation training also…

  3. 15 CFR 930.115 - Termination of mediation.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Termination of mediation. 930.115... MANAGEMENT FEDERAL CONSISTENCY WITH APPROVED COASTAL MANAGEMENT PROGRAMS Secretarial Mediation § 930.115 Termination of mediation. Mediation shall terminate: (a) At any time the Federal and State agencies agree to...

  4. Estimating and Testing Mediation Effects with Censored Data

    Science.gov (United States)

    Wang, Lijuan; Zhang, Zhiyong

    2011-01-01

    This study investigated influences of censored data on mediation analysis. Mediation effect estimates can be biased and inefficient with censoring on any one of the input, mediation, and output variables. A Bayesian Tobit approach was introduced to estimate and test mediation effects with censored data. Simulation results showed that the Bayesian…

  5. 29 CFR 1207.2 - Requests for Mediation Board action.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Requests for Mediation Board action. 1207.2 Section 1207.2 Labor Regulations Relating to Labor (Continued) NATIONAL MEDIATION BOARD ESTABLISHMENT OF SPECIAL ADJUSTMENT BOARDS § 1207.2 Requests for Mediation Board action. (a) Requests for the National Mediation...

  6. Health psychology as a context for massage therapy: a conceptual model with CAM as mediator.

    Science.gov (United States)

    Hymel, Glenn M; Rich, Grant J

    2014-04-01

    Health psychology represents a context within which massage therapy research, education, and practice can be positioned for the mutual benefit of both. Furthermore, complementary and alternative medicine (CAM) more often than not plays a mediating role in relating massage therapy to health psychology. On occasion, though, the linkage between health psychology and massage therapy can be quite direct without the mediating influence of CAM. This paper, accordingly, advances a conceptual model via both flowchart and Venn diagram displays for viewing the health psychology context for massage therapy with the possibility of CAM as a mediating factor. Attention is also given to the broad range of issues constituting contemporary health psychology as well as its correspondence to an equally diverse array of client populations and health conditions addressed in massage therapy research. Future directions in the areas of health psychology, CAM, and massage therapy are proposed with a view toward a mutual and reciprocal benefit accruing to these behavioral and health science arenas.

  7. Mediating factors of land use change among coffee farmers in a biological corridor

    DEFF Research Database (Denmark)

    Bosselmann, Aske Skovmand

    2012-01-01

    Trees in agricultural landscapes are important for the provision of environmental services. This study assesses the loss of shade coffee during a 9 year period in a biological corridor in Costa Rica, and investigates the mediating factors of land use change. Following a conceptual framework...... that presents how household and farm characteristics mediate the interplay between underlying and proximate causes of land use change, the effect of the mediating factors is determined by applying an ordered probit model to household and land use data for 2000 and 2009 from 217 former and present coffee farmers....... Additional 224 telephone interviews supplement the data on land use change. Results show a 50% reduction in the coffee area and a corresponding loss of trees. Family labor, age of household head, coffee prices, and use of shade tree products significantly reduce the probability of converting the coffee field...

  8. MANAGEMENT IN RURAL AREAS

    Directory of Open Access Journals (Sweden)

    Danimir Štros

    2015-07-01

    Full Text Available Croatia has been seeking to achive pre-war results in tourism since its independence. Rural tourism in Croatia based on family farma faces a number of problems legal foundations, the involement of local communities, inadequate entepreneur support etc. The political will for development exists, but there is lack of willingness and the ability to get things started, which results in the closure of family farma who cannot cope with the parallel job of agriculture and tourism. Arriving guests certainly want a new type of tourism: peace, clean environment, cultural intangible and tangible treasures, all without the noise and stress; and Croatia can definitely offer it, either in coastal or inland areas with traditional food and drinks. The destinations connection is not satisfactora. there is also an evident lack of legislation and regional spatial development plans for sustainable tourism which is a prerequisite for successful tourism. With these plans presumptins accepted, Croatian tourism would become distinctive and inland and coastal branches of tourism could complement each other so that the customer can spend his vacation both in the continental ant the maritime part of the country, getting to know our culture and enjoy the traditional cousine.

  9. Global protected area impacts.

    Science.gov (United States)

    Joppa, Lucas N; Pfaff, Alexander

    2011-06-01

    Protected areas (PAs) dominate conservation efforts. They will probably play a role in future climate policies too, as global payments may reward local reductions of loss of natural land cover. We estimate the impact of PAs on natural land cover within each of 147 countries by comparing outcomes inside PAs with outcomes outside. We use 'matching' (or 'apples to apples') for land characteristics to control for the fact that PAs very often are non-randomly distributed across their national landscapes. Protection tends towards land that, if unprotected, is less likely than average to be cleared. For 75 per cent of countries, we find protection does reduce conversion of natural land cover. However, for approximately 80 per cent of countries, our global results also confirm (following smaller-scale studies) that controlling for land characteristics reduces estimated impact by half or more. This shows the importance of controlling for at least a few key land characteristics. Further, we show that impacts vary considerably within a country (i.e. across a landscape): protection achieves less on lands far from roads, far from cities and on steeper slopes. Thus, while planners are, of course, constrained by other conservation priorities and costs, they could target higher impacts to earn more global payments for reduced deforestation.

  10. Catchment areas for public transport

    DEFF Research Database (Denmark)

    Andersen, Jonas Lohmann Elkjær; Landex, Alex

    2008-01-01

    the simplest approach. The Service Area approach is based on searches in road networks and represents the actual feeder routes and is thereby a more detailed approach. The Service Area approach can be refined by adding additional resistance to certain points in the road network, e.g. stairways. Differences...... by calculating travel potential along the line. The article shows how the different approaches result in differences in the examined catchment areas. It shows how the Service Area approach prevents inaccessible areas to be included in the catchment area and how it allows for detours in feeder routes to....../from stations. The article also shows how the refinement of the Service Area approach with additional time resistance results in smaller catchment areas when the feeder routes cross stairs. It is concluded that GIS-based catchment area analyses are a multiple decision support tool for planning of public...

  11. Water Service Areas - Public Water Supplier's (PWS) Service Areas

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Boundaries of current public water supplier's (PWS) service areas. This data set contains the present service area boundary of the water system and does not contain...

  12. DISPUTE RESOLUTION AND MEDIATION ON CAPITAL MARKET

    Directory of Open Access Journals (Sweden)

    CRISTIAN GHEORGHE

    2011-04-01

    Full Text Available Capital Market is usually depicted as a place for experts, for people with high trading skills. This is a half truth. There are entities established and functioning under strict scrutiny of Romanian National Securities Commission (RNSC, in compliance with Capital Market Law and regulations. There are also the investors, in many cases individuals involved in shares/financial instruments trade. In both cases disputes can rise. Disputes are inevitable a part of human interaction, hence the need for dispute resolution. First option is the judicial court system. Alternative dispute resolution comprises arbitration and mediation. Arbitration is an alternative choice to provide simpler, speedier and more accessible justice than ordinary courts as well as expertise in matters that are technical in nature and require special knowledge to adjudicate upon. Capital Market environment provides an institutional arbitration court for all participants, including investors. In many cases the agreement executed between participants under RNSC scrutiny The other option for settling disputes outside the court is mediation. Mediation can provide a much cheaper and quick extrajudicial resolution of disputes in commercial matters without time consuming procedures and rigid rules. Agreements resulting from mediation are more likely to be complied with voluntarily and are more likely to foster the commercial relationship between the parties. The interaction between investors and brokerage houses is based on investment services agreement concluded by parties. This is the usual framework for disputes between parties and the usual “landscape” for mediation on capital market.

  13. Realistic anomaly mediation with bulk gauge fields

    International Nuclear Information System (INIS)

    We present a simple general framework for realistic models of supersymmetry breaking driven by anomaly mediation. We consider a 5-dimensional 'brane universe' where the visible and hidden sectors are localized on different branes, and the standard model gauge bosons propagate in the bulk. In this framework there can be charged scalar messengers that have contact interactions with the hidden sector, either localized in the hidden sector or in the bulk. These scalars obtain soft masses that feed into visible sector scalar masses at two loop order via bulk gauge interactions. This contribution is automatically flavor-blind, and can be naturally positive. If the messengers are in the bulk this contribution is automatically the same order of magnitude as the anomaly mediated contribution, independent of the brane spacing. If the messengers are localized to a brane the two effects are of the same order for relatively small brane spacings. The gaugino masses and A terms are determined completely by anomaly mediation. In order for anomaly mediation to dominate over radion mediation the radion must be is stabilized in a manner that preserves supersymmetry, with supergravity effects included. We show that this occurs in simple models. We also show that the mu problem can be solved by the vacuum expectation value of a singlet in this framework. (author)

  14. Human Communication as Mediating the Units of Parameterised Environment

    OpenAIRE

    Josip Stepanic

    2004-01-01

    Human communication is prevalently a mediated process. Mediators are units of environment, which are attributed functions within the local value set. They are utilised in such a way as to optimise the change of human states. In this article, a mediator-centred interpretation of the human communication is given. The interpretation follows closely the concept of mediated interaction developed within physics. It is conjectured that collection of mediators, which the humans use, has a well-define...

  15. Carbon nanotubes as cancer therapeutic carriers and mediators

    Science.gov (United States)

    Son, Kuk Hui; Hong, Jeong Hee; Lee, Jin Woo

    2016-01-01

    Carbon nanotubes (CNTs) have received increasing attention in biomedical fields because of their unique structures and properties, including high aspect ratios, large surface areas, rich surface chemical functionalities, and size stability on the nanoscale. Particularly, they are attractive as carriers and mediators for cancer therapy. Through appropriate functionalization, CNTs have been used as nanocarriers for anticancer drugs including doxorubicin, camptothecin, carboplatin, cisplatin, paclitaxel, Pt(II), and Pt(IV), and genes including plasmid DNA, small-interfering RNA, oligonucleotides, and RNA/DNA aptamers. CNTs can also deliver proteins and immunotherapy components. Using combinations of light energy, they have also been applied as mediators for photothermal therapy and photodynamic therapy to directly destroy cancer cells without severely damaging normal tissue. If limitations such as a long-term cytotoxicity in the body, lack of size uniformity during the synthetic process, loading deviations for drug–CNT complexes, and release controllability at the target point are overcome, CNTs will become one of the strongest tools that are available for various other biomedical fields as well as for cancer therapy. PMID:27785021

  16. Recent advances in engineering topography mediated antibacterial surfaces

    Science.gov (United States)

    Hasan, Jafar; Chatterjee, Kaushik

    2015-09-01

    The tendency of bacterial cells to adhere and colonize a material surface leading to biofilm formation is a fundamental challenge underlying many different applications including microbial infections associated with biomedical devices and products. Although, bacterial attachment to surfaces has been extensively studied in the past, the effect of surface topography on bacteria-material interactions has received little attention until more recently. We review the recent progress in surface topography based approaches for engineering antibacterial surfaces. Biomimicry of antibacterial surfaces in nature is a popular strategy. Whereas earlier endeavors in the field aimed at minimizing cell attachment, more recent efforts have focused on developing bactericidal surfaces. However, not all such topography mediated bactericidal surfaces are necessarily cytocompatible thus underscoring the need for continued efforts for research in this area for developing antibacterial and yet cytocompatible surfaces for use in implantable biomedical applications. This mini-review provides a brief overview of the current strategies and challenges in the emerging field of topography mediated antibacterial surfaces.

  17. Robot-Mediated Imitation Skill Training for Children With Autism.

    Science.gov (United States)

    Zheng, Zhi; Young, Eric M; Swanson, Amy R; Weitlauf, Amy S; Warren, Zachary E; Sarkar, Nilanjan

    2016-06-01

    Autism spectrum disorder (ASD) impacts 1 in 68 children in the U.S., with tremendous individual and societal costs. Technology-aided intervention, more specifically robotic intervention, has gained momentum in recent years due to the inherent affinity of many children with ASD towards technology. In this paper we present a novel robot-mediated intervention system for imitation skill learning, which is considered a core deficit area for children with ASD. The Robot-mediated Imitation Skill Training Architecture (RISTA) is designed in such a manner that it can operate either completely autonomously or in coordination with a human therapist depending on the intervention need. Experimental results are presented from small user studies validating system functionality, assessing user tolerance, and documenting subject performance. Preliminary results show that this novel robotic system draws more attention from the children with ASD and teaches gestures more effectively as compared to a human therapist. While no broad generalized conclusions can be made about the effectiveness of RISTA based on our small user studies, initial results are encouraging and justify further exploration in the future. PMID:26353376

  18. Socialising Semiotic Mediation: Some Reflections on Rosa and Pievi's Paper

    Directory of Open Access Journals (Sweden)

    Glaveanu, V.

    2013-11-01

    Full Text Available This article aims to reflect on the relation between social representations theory (SRT and a cultural psychological view of semiotics, as presented in Rosa and Pievi's paper (this issue. It is argued that a fruitful dialogue can be established between the two orientations, one that draws on similarities but also addresses and exploits several important conceptual differences. The article proceeds by outlining the areas in which SRT can be enriched by a semiotic account – such as incorporating a more clearly articulated theory of signs and unpacking further the role of mediated action and personal experience – as well as the ways in which the latter can benefit from engaging with the notion of social representations. Most of all, I propose that what a SRT-informed view of cultural psychology can offer us is a ‘socialized model of semiotic mediation', one that grounds the construction of knowledge at the level of different groups and communities and observes its dynamic evolution over time in close relation to these social milieus. The transformation of knowledge and its individual and social determinants are considered in detail by SRT researchers and can expand the rather narrow focus on sign, object and meaning in more traditional forms of semiotic analysis. In the end, some methodological reflections are offered and the existence of social representations as a phenomenon is affirmed beyond the realm of purely scientific construction.

  19. Reclamation of urban areas

    International Nuclear Information System (INIS)

    A literature study was conducted in order to compare the effectiveness and cost of different reclamation procedures that may be employed after an accident on a nuclear facility takes place in which radioactive material is released to the atmosphere. A substantial amount of work has been done on reclaming soil and snow-covered surfaces. Using scrapers or other soil-moving equipment decontamination factors are 10-100. (The decontamination factor is the ratio of the contamination before to that after the decontamination procedure). However, information on decontamination of paved areas by simple methods such as firehosing and vacuum sweeping are poorly documented. Therefore, only a very uncertain figure in the range 2-10 can be given for the decontamination factor here. It is recommended that a major effort be made in the future to investigate the efficiency of these simple methods, because of their relatively low cost. Also, more expensive methods for reducing the dose such as vacuuming, road planing and deep plowing are treated because of their feasibility under certain circumstances. Using these methods dose reduction factors in the 2-100 range can be obtained. Very expensive techniques, such as sandblasting, water cannon, flame spalling, etc. are justifiable usable only in special situations and are therefore considered very briefly here. The methods vary widely in cost. A simple method like vacuum sweeping costs $0.004 per square meter of surface; whereas one like road planing can reach $4 per square meter. A more sophisticated technique like flame spalling costs as much as $100 per square meter. (author)

  20. Social cognition as a mediator of cognition and outcome among deaf and hearing people with schizophrenia.

    Science.gov (United States)

    Horton, Heather K; Silverstein, Steven M

    2008-10-01

    It has been suggested in the research literature that facial affect processing (FAP) and theory of mind (ToM) are both potential mediators of the well-established relationship between cognition and functional outcome among people with schizophrenia. The current project tests the mediating potency of these two domains of social cognition among deaf and hearing people with schizophrenia. Sixty-five people (34 deaf, 31 hearing) were assessed using measures of verbal and visual memory, attention, visual processing, FAP, and ToM. The results suggest that each domain of cognition, save vigilance, exerts an effect on functional outcome indirectly through its influence on social cognition. The patterns of mediation varied when the samples were broken down by hearing status and analyzed separately. Namely, the cognitive tasks directly involving linguistic ability (early visual processing [EVP] and word memory) were best mediated by social cognition for hearing subjects. For deaf subjects, the nonlinguistic cognitive tasks (e.g., visual-spatial memory-recall and copy [VSM-recall and VSM-copy]) were best mediated by social cognition. While FAP and ToM were equally effective as mediators for hearing subjects, FAP was a more potent mediator than ToM for deaf subjects. This study extends prior work in the area of social cognition and schizophrenia and indicates that the development of cognitive rehabilitation strategies should include not only interventions targeting specific cognitive abilities, such as attention and memory, but should include an emphasis on social-cognitive domains, including FAP and ToM. Further, deaf and hearing subjects may benefit from interventions addressing aspects of cognition that support linguistic ability, especially as they relate to social cognition.

  1. Digital methods for mediated discourse analysis

    DEFF Research Database (Denmark)

    Kjær, Malene; Larsen, Malene Charlotte

    2015-01-01

    In this paper we discuss methodological strategies for collecting multimodal data using digital resources. The aim is to show how digital resources can provide ethnographic insights into mediated actions (Scollon, 2002) that can otherwise be difficult to observe or engage in, due to, for instance......, restrictions or privately mediated settings. Having used mediated discourse analysis (Scollon 2002, Scollon & Scollon, 2004) as a framework in two different research projects, we show how the framework, in correlation with digital resources for data gathering, provides new understandings of 1) the daily...... practice of health care professionals (Author 1, 2014) and 2) young people’s identity construction on social media platforms (Author 2, 2010, 2015, in press). The paper’s contribution is a methodological discussion on digital data collection using methods such as online interviewing (via e-mail or chat...

  2. Considerations about mediative in initial petition

    Directory of Open Access Journals (Sweden)

    Maria das Vitórias Nunes Silva Lourenço

    2013-12-01

    Full Text Available This paper presents considerations about Initial Petition, textual/discursive genre, which is a genre circumscribed in the judicial domain with relation to the Commitment. For this purpose, this article exposes the text plan of the Initial Petition from the postulations of Adam (2011. In the same way, it studies the mediative frameworks based on Guentchéva (1994, 1996, which develop the notion of mediative grammatical categories, that permits the linguistic marking of distance and engagement of the enunciator with regard to the information expressed. It evidences the relevance of the use of mediated constructions in the judicial text, as they function as attenuated strategies to the responsibility of the producer of the text with what is said, and at the same time points to a discourse of authority through the entrance of the sources of law.

  3. When Anomaly Mediation is UV Sensitive

    CERN Document Server

    Setzer, N

    2010-01-01

    Despite its successes---such as solving the supersymmetric flavor problem---anomaly mediated supersymmetry breaking is untenable because of its prediction of tachyonic sleptons. An appealing solution to this problem was proposed by Pomerol and Rattazzi where a threshold controlled by a light field deflects the anomaly mediated supersymmetry breaking trajectory, thus evading tachyonic sleptons. In this paper we present an alternate class of deflection models where the non-supersymmetric threshold is accompanied by a heavy, instead of light, singlet. Its existence demonstrates that the space of anomaly mediated supersymmetry breaking deflecting models is larger than previously thought, though both types of deflection share the general property that the threshold is generated by SUSY breaking terms. We discuss these deflections scenarios and make use of the alternative class in a simple example.

  4. Fragments of “analytics” of mediatization

    Directory of Open Access Journals (Sweden)

    Antônio Fausto Neto

    2008-04-01

    Full Text Available The text intends, through a dialogue with authors, to reflect about the concept of “analytics of the mediatization”, taking the evolution from the “society of means” to the “mediatic society” as reference. It ties the emergency of this new “interpretative strategies” to the increasing autonomy of the media field, that imposes, from its part, transformation in the “contracts” and in the bonds between the production structures and the reception of mediatic discourses. Finally, it proposes the  comprehension of this “analytics” as a concept associated to the practices that are structured and developed from operations of sense engendered in the enunciative ambit of the mediatic culture.

  5. U(1) mediation of flux supersymmetry breaking

    International Nuclear Information System (INIS)

    We study the mediation of supersymmetry breaking triggered by background fluxes in Type II string compactifications with N = 1 supersymmetry. The mediation arises due to an U(1) vector multiplet coupling to both a hidden supersymmetry breaking flux sector and a visible D-brane sector. The required internal manifolds can be constructed by non-Kaehler resolutions of singular Calabi-Yau manifolds. The effective action encoding the U(1) coupling is then determined in terms of the global topological properties of the internal space. We investigate suitable local geometries for the hidden and visible sector in detail. This includes a systematic study of orientifold symmetries of del Pezzo surfaces realized in compact geometries after geometric transition. We construct compact examples admitting the key properties to realize flux supersymmetry breaking and U(1) mediation. Their toric realization allows us to analyze the geometry of curve classes and confirm the topological connection between the hidden and visible sector.

  6. Agrobacterium-mediated transformation of cotton.

    Science.gov (United States)

    Zhang, Baohong

    2013-01-01

    There are many methods and techniques that can be used to transfer foreign genes into cells. In plant biotechnology, Agrobacterium-mediated transformation is a widely used traditional method for inserting foreign genes into plant genome and obtaining transgenic plants, particularly for dicot plant species. Agrobacterium-mediated transformation of cotton involves several important and also critical steps, which includes coculture of cotton explants with Agrobacterium, induction and selection of stable transgenic cell lines, recovery of plants from transgenic cells majorly through somatic embryogenesis, and detection and expression analysis of transgenic plants. In this chapter, we describe a detailed step-by-step protocol for obtaining transgenic cotton plants via Agrobacterium-mediated transformation.

  7. Enhancing Educational Opportunities with Computer-Mediated Assessment Feedback

    Directory of Open Access Journals (Sweden)

    David Tuffley

    2015-08-01

    Full Text Available As internet technologies make their way into developing areas, so too does the possibility of education and training being delivered to the people living in those previously unserved areas. The growing catalogue of free, high quality courseware, when combined with the newly acquired means of delivery, creates the potential for millions of people in the developing world to acquire a good education. Yet a good education obviously requires more than simply delivering information; students must also receive high quality feedback on their assessments. They must be told how their performance compares with the ideal, and be shown how to close the gap between the two. However, delivering high quality feedback is labor-intensive, and therefore expensive, and has long been recognized as a problematic issue by educators. This paper outlines a case study that uses a Learning Management System (LMS to efficiently deliver detailed feedback that is informed by the principles of best practice. We make the case that the efficiencies of this method allow for large-scale courses with thousands of enrolments that are accessible to developing and developed areas alike. We explore the question; is computer-mediated feedback delivery efficient and effective and might it be applied to large-scale courses at low-cost?

  8. Does drinking refusal self-efficacy mediate the impulsivity-problematic alcohol use relation?

    Science.gov (United States)

    Stevens, Angela K; Littlefield, Andrew K; Blanchard, Brittany E; Talley, Amelia E; Brown, Jennifer L

    2016-02-01

    There is consistent evidence that impulsivity-like traits relate to problematic alcohol involvement; however, identifying mechanisms that account for this relation remains an important area of research. Drinking refusal self-efficacy (or a person's ability to resist alcohol; DRSE) has been shown to predict alcohol use among college students and may be a relevant mediator of the impulsivity-alcohol relation. The current study examined the indirect effect of various constructs related to impulsivity (i.e., urgency, sensation seeking, and deficits in conscientiousness) via several facets of DRSE (i.e., social pressure, opportunistic, and emotional relief) on alcohol-related problems among a large sample of college students (N=891). Overall, results indicated that certain DRSE facets were significant mediators of the relation between impulsivity-related constructs and alcohol problems. More specifically, emotional-relief DRSE was a mediator for the respective relations between urgency and deficits in conscientiousness and alcohol problems, whereas social-DRSE was a significant mediator of the respective relations between urgency and sensation seeking with alcohol problems. Results from this study suggest particular types of DRSE are important mediators of the relations between specific impulsivity constructs and alcohol-related problems. These findings support prevention and intervention efforts that seek to enhance drinking refusal self-efficacy skills of college students, particularly those high in certain personality features, in order to reduce alcohol-related problems among this population. PMID:26547044

  9. Does drinking refusal self-efficacy mediate the impulsivity-problematic alcohol use relation?

    Science.gov (United States)

    Stevens, Angela K; Littlefield, Andrew K; Blanchard, Brittany E; Talley, Amelia E; Brown, Jennifer L

    2016-02-01

    There is consistent evidence that impulsivity-like traits relate to problematic alcohol involvement; however, identifying mechanisms that account for this relation remains an important area of research. Drinking refusal self-efficacy (or a person's ability to resist alcohol; DRSE) has been shown to predict alcohol use among college students and may be a relevant mediator of the impulsivity-alcohol relation. The current study examined the indirect effect of various constructs related to impulsivity (i.e., urgency, sensation seeking, and deficits in conscientiousness) via several facets of DRSE (i.e., social pressure, opportunistic, and emotional relief) on alcohol-related problems among a large sample of college students (N=891). Overall, results indicated that certain DRSE facets were significant mediators of the relation between impulsivity-related constructs and alcohol problems. More specifically, emotional-relief DRSE was a mediator for the respective relations between urgency and deficits in conscientiousness and alcohol problems, whereas social-DRSE was a significant mediator of the respective relations between urgency and sensation seeking with alcohol problems. Results from this study suggest particular types of DRSE are important mediators of the relations between specific impulsivity constructs and alcohol-related problems. These findings support prevention and intervention efforts that seek to enhance drinking refusal self-efficacy skills of college students, particularly those high in certain personality features, in order to reduce alcohol-related problems among this population.

  10. Development of mediated BOD biosensor system of flow injection mode for shochu distillery wastewater.

    Science.gov (United States)

    Oota, Shinichi; Hatae, Yuta; Amada, Kei; Koya, Hidekazu; Kawakami, Mitsuyasu

    2010-09-15

    Although microbial biochemical oxygen demand (BOD) sensors utilizing redox mediators have attracted much attention as a rapid BOD measurement method, little attempts have been made to apply the mediated BOD biosensors to the flow injection analysis system. In this work, a mediated BOD sensor system of flow injection mode, constructed by combining an immobilized microbial reactor with an electrochemical flow cell of three electrodes configuration, has been developed to estimate BOD of shochu distillery wastewater (SDW). It was demonstrated consequently that the mediated sensing was realized by employing phosphate buffer containing potassium hexacyanoferrate as the carrier. The output current was found to yield a peak with a sample injection, and to result from reoxidation of reduced mediator at the electrode. By employing the peak area as the sensor response, the effects of flow rate and pH of the carrier on the sensitivity were investigated. The sensor system using a microorganism of high SDW-assimilation capacity showed good performance and proved to be available for estimation of BOD of SDW.

  11. Angular dependence of surfactant-mediated forces between carbon nanotubes.

    Science.gov (United States)

    Müter, Dirk; Angelikopoulos, Panagiotis; Bock, Henry

    2012-12-27

    We employ dissipative particle dynamics to examine surfactant-mediated forces between two carbon nanotubes. Calculations are performed varying both the distance and the angle between the nanotubes. For small distances, a repulsive region is observed, followed by an overall attractive interval with strong oscillations in the force. Decreasing the angle between the tubes leads to a steady increase in the force, but the relative dependence on the separation distance is preserved. We find that the force scales linearly with the size of the overlap area between the tubes. This allows us to express the angle dependence by a simple equation, whereas the distance dependence is represented by a master curve. For the parallel case, the behavior is significantly different. PMID:23116052

  12. LIHTC Difficult to Develop Areas

    Data.gov (United States)

    Department of Housing and Urban Development — A Difficult Development Area (DDA) for the Low Income Housing Tax Credit program is an area designated by the U.S. Department of Housing and Urban Development (HUD)...

  13. Major Land Resource Areas (MLRA)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This is a polygon coverage of the Land Resource Regions and Major Land Resource Areas of the conterminous United States. Land resource regions are geographic areas...

  14. Facial Areas and Emotional Information

    Science.gov (United States)

    Boucher, Jerry D.; Ekman, Paul

    1975-01-01

    Provides strong support for the view that there is no one area of the face which best reveals emotion, but that the value of the different facial areas in distinguishing emotions depends upon the emotion being judged. (Author)

  15. Catch-In-Areas Main

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Catch-In-Areas database integrates catch data from the Catch Accounting System (which has the spatial resolution of a NMFS Reporting Area) into a database that...

  16. Area monitoring intelligent system - SIMA

    International Nuclear Information System (INIS)

    The area monitoring intelligent system (SIMA) is an equipment to be used in radioprotection. SIMA has the function of monitoring the radiation levels of determined areas of the installations where radioactive materials are handled. (Author)

  17. Cholera in Azov area

    Directory of Open Access Journals (Sweden)

    O. N. Domashenko

    2015-07-01

    Full Text Available The purpose of research is analysis of clinical course and treatment results of patients with cholera in the Azov area. Materials and methods. During the period from 29.05.2011 to 19.08.2011 33 cases of cholera (32 adults and 1 child and 25 vibrio carriers (22 adults and 3 children, which were caused by toxigenic strains of Vibrio cholera El Tor serogroup O1 Ogawa. Results. Likely factors of disease transmission in Mariupol are sea and river water, and the fish that were caught in the waters of the city. Typical and watery diarrhoea, vomiting, abdominal pain and lack of normal body temperature, dehydration syndrome, characterized clinical cholera for adults in most cases. The mean duration of diarrhoea was 6,6 days. At 46.9% observed atypical symptoms in 10 (31,3% – abdominal pain (1 patient cramping in 7 cases, localized in the epigastria region, at 2-over stomach. In 5 patients (15,6% had an increase in body temperature to 37,2–37,7 degrees Celsius. In 15 (46,9% patients had severe nausea accompanied by vomiting. Easy for cholera was observed in 1 (3.1%, moderate – in 14 (43,8%, heavy – in 17 (53,1% patients. Dehydration I level is set at 4 (12,5%, II – from 6 (18,7%, III – in 18 (56,3%, IV – 4 (12,5% patients. Cholera outbreak was characterized by a predominance of severe disease and severe dehydration (III and IV, which was observed in 68.8% of patients. The decisive factor in the treatment of cholera patients was initiated in a timely manner rehydration therapy, in particular the introduction of the solution «Trisol». Against the background of rehydration therapy hyperkalaemia was observed in 9,4% of cases, vascular rehydration at 9,4%, the cell rehydration in 3,1% of patients. Fatal accidents cholera outbreaks have not been observed. Conclusion. Clinical diagnosis of cholera and the provision of medical care in the prehospital phase were poor, indicating the need for systematic conducting training seminars among experts

  18. Spatial interplay of plant competition and consumer foraging mediate plant coexistence and drive the invasion ratchet.

    Science.gov (United States)

    Orrock, John L; Baskett, Marissa L; Holt, Robert D

    2010-11-01

    Indirect effects may play an important role in structuring plant communities. Using a spatially explicit model of consumer foraging and plant competition, we demonstrate how the relationship between the spatial area over which plants compete and the spatial scale of consumer behaviour can determine the outcome of competition when one plant species provides a refuge for mobile consumers (i.e. refuge-mediated apparent competition). Once an initial population of the invader is established, complete invasion may be inevitable because of an ever-advancing invasion front ratchets forward driven by a feeding front of mobile consumers. Because the spatial extent of apparent competition determines the area available for colonization, consumers may also dictate the rate at which an invasion occurs. We find that, as long as refuge-mediated apparent competition is sufficiently localized, invasion is possible even in systems characterized by low overall levels of consumer pressure. Moreover, we show that a stable equilibrium can result in which both resident and invading plants coexist, suggesting that spatial heterogeneity created by refuge-mediated apparent competition may be important in mediating coexistence in plant communities. The spatial interplay of consumer behaviour and plant competition may be an underappreciated mechanism affecting the composition, diversity and spatial pattern of plant communities.

  19. Metatv: the mediation as an apprehended reality

    Directory of Open Access Journals (Sweden)

    Márcio Serelle

    2009-06-01

    Full Text Available The television that narrates itself, as an intensification of neotv skills, pointed out by Eco, emphasizes their mediation processes, as the reality to be apprehended by the spectators was that of the medium’s inner side. Considering the notions of media transparency and opacity, this article aims at analyzing the meanings of this metalanguage acts present in many levels of the programming. This text examines closely the enunciation strategies of two programs: Profissão reporter and Cena aberta, which specular attitude reveals, in the media culture, the fascination by television mediation.

  20. Transition to whistler mediated magnetic reconnection

    Science.gov (United States)

    Mandt, M. E.; Denton, R. E.; Drake, J. F.

    1994-01-01

    The transition in the magnetic reconnection rate from the resistive magnetohydrodynamic (MHD) regime where the Alfen wave controls reconnection to a regime in which the ions become unmagnetized and the whistler wave mediates reconnection is explored with 2-D hybrid simulations. In the whistler regime the electrons carry the currents while the ions provide a neutralizing background. A simple physical picture is presented illustrating the role of the whistler mediated reconnection is calculated analytically. The development of an out-of-plane component of the magnetic field is an observable signature of whistler driven reconnection.

  1. Purely Four-dimensional Viable Anomaly Mediation

    CERN Document Server

    Harnik, R; Pierce, A T; Harnik, Roni; Murayama, Hitoshi; Pierce, Aaron

    2002-01-01

    Anomaly mediation of supersymmetry breaking solves the supersymmetric flavor problem thanks to its ultraviolet-insensitivity. However, it suffers from two problems: sleptons have negative masses-squared, and there are likely bulk moduli that spoil the framework. Here, we present the first fully ultraviolet-insensitive model of anomaly mediation with positive slepton masses-squared in a purely four-dimensional framework. Our model is based on the additional D-term contributions to the sparticle masses of Arkani-Hamed, Kaplan, HM, and Nomura, and the conformal sequestering mechanism of Luty and Sundrum.

  2. Extended tree-level gauge mediation

    DEFF Research Database (Denmark)

    Monaco, M.; Nardecchia, M.; Romanino, A.;

    2011-01-01

    Tree-level gauge mediation (TGM) is a scenario of SUSY breaking in which the tree-level exchange of heavy (possibly GUT) vector fields generates flavor-universal sfermion masses. In this work we extend this framework to the case of E(6) that is the natural extension of the minimal case studied so...... if the gauge group does not contain SU(5). If SUSY breaking is mediated purely by the U(1) generator that commutes with SO(10) we obtain universal sfermion masses and thus can derive the CMSSM boundary conditions in a novel scenario....

  3. Purley four-dimensional viable anomaly mediation

    International Nuclear Information System (INIS)

    Anomaly mediation of supersymmetry breaking solves the supersymmetric flavor problem thanks to its ultraviolet-insensitivity. However, it suffers from two problems: sleptons have negative masses-squared, and there are likely bulk moduli that spoil the framework. Here, we present the first fully ultraviolet-insensitive model of anomaly mediation with positive slepton masses-squared in a purely four-dimensional framework. Our model is based on the additional D-term contributions to the sparticle masses, and the conformal sequestering mechanism. (author)

  4. A Microscopic Theory of Gauge Mediation

    International Nuclear Information System (INIS)

    We construct models of indirect gauge mediation where the dynamics responsible for breaking supersymmetry simultaneously generates a weakly coupled subsector of messengers. This provides a microscopic realization of messenger gauge mediation where the messenger and hidden sector fields are unified into a single sector. The UV theory is SQCD with massless and massive quarks plus singlets, and at low energies it flows to a weakly coupled quiver gauge theory. One node provides the primary source of supersymmetry breaking, which is then transmitted to the node giving rise to the messenger fields. These models break R-symmetry spontaneously, produce realistic gaugino and sfermion masses, and give a heavy gravitino.

  5. A simple model of direct gauge mediation

    International Nuclear Information System (INIS)

    In the context of direct gauge mediation Wess-Zumino models are very attractive in supersymmetry model building. Besides the spontaneous supersymmetry and R-symmetry breaking, the problems of small gaugino mass as well as μ and Bμ terms should be solved so as to achieve a viable model. In this Letter, we propose a simple model as an existence proof, in which all these subjects are realized simultaneously, with no need of fine tuning. This completion also implies that much of parameter space for direct gauge mediation can be directly explored at LHC.

  6. Flexible Mediation Analysis in the Presence of Nonlinear Relations: Beyond the Mediation Formula.

    Science.gov (United States)

    Loeys, Tom; Moerkerke, Beatrijs; De Smet, Olivia; Buysse, Ann; Steen, Johan; Vansteelandt, Stijn

    2013-11-01

    In the social sciences, mediation analysis has typically been formulated in the context of linear models using the Baron & Kenny (1986) approach. Extensions to nonlinear models have been considered but lack formal justification. By placing mediation analysis within the counterfactual framework of causal inference one can define causal mediation effects in a way that is not tied to a specific statistical model and identify them under certain no unmeasured confounding assumptions. Corresponding estimation procedures using parametric or nonparametric models, based on the so-called mediation formula, have recently been proposed in the psychological literature and made accessible through the R-package mediation. A number of limitations of the latter approach are discussed and a more flexible approach using natural effects models is proposed as an alternative. The latter builds on the same counterfactual framework but enables interpretable and parsimonious modeling of direct and mediated effects and facilitates tests of hypotheses that would otherwise be difficult or impossible to test. We illustrate the approach in a study of individuals who ended a romantic relationship and explore whether the effect of attachment anxiety during the relationship on unwanted pursuit behavior after the breakup is mediated by negative affect during the breakup. PMID:26745597

  7. Auxin-dependent compositional change in Mediator in ARF7- and ARF19-mediated transcription.

    Science.gov (United States)

    Ito, Jun; Fukaki, Hidehiro; Onoda, Makoto; Li, Lin; Li, Chuanyou; Tasaka, Masao; Furutani, Masahiko

    2016-06-01

    Mediator is a multiprotein complex that integrates the signals from transcription factors binding to the promoter and transmits them to achieve gene transcription. The subunits of Mediator complex reside in four modules: the head, middle, tail, and dissociable CDK8 kinase module (CKM). The head, middle, and tail modules form the core Mediator complex, and the association of CKM can modify the function of Mediator in transcription. Here, we show genetic and biochemical evidence that CKM-associated Mediator transmits auxin-dependent transcriptional repression in lateral root (LR) formation. The AUXIN/INDOLE 3-ACETIC ACID 14 (Aux/IAA14) transcriptional repressor inhibits the transcriptional activity of its binding partners AUXIN RESPONSE FACTOR 7 (ARF7) and ARF19 by making a complex with the CKM-associated Mediator. In addition, TOPLESS (TPL), a transcriptional corepressor, forms a bridge between IAA14 and the CKM component MED13 through the physical interaction. ChIP assays show that auxin induces the dissociation of MED13 but not the tail module component MED25 from the ARF7 binding region upstream of its target gene. These findings indicate that auxin-induced degradation of IAA14 changes the module composition of Mediator interacting with ARF7 and ARF19 in the upstream region of their target genes involved in LR formation. We suggest that this regulation leads to a quick switch of signal transmission from ARFs to target gene expression in response to auxin. PMID:27217573

  8. MPLS for metropolitan area networks

    CERN Document Server

    Tan, Nam-Kee

    2004-01-01

    METROPOLITAN AREA NETWORKS AND MPLSRequirements of Metropolitan Area Network ServicesMetropolitan Area Network OverviewThe Bandwidth DemandThe Metro Service Provider's Business ApproachesThe Emerging Metro Customer Expectations and NeedsSome Prevailing Metro Service OpportunitiesService Aspects and RequirementsRoles of MPLS in Metropolitan Area NetworksMPLS PrimerMPLS ApplicationsTRAFFIC ENGINEERING ASPECTS OF METROPOLITAN AREA NETWORKSTraffic Engineering ConceptsNetwork CongestionHyper Aggregation ProblemEasing CongestionNetwork ControlTactical versus Strategic Traffic EngineeringIP/ATM Overl

  9. Fractal cartography of urban areas.

    Science.gov (United States)

    Encarnação, Sara; Gaudiano, Marcos; Santos, Francisco C; Tenedório, José A; Pacheco, Jorge M

    2012-01-01

    In a world in which the pace of cities is increasing, prompt access to relevant information is crucial to the understanding and regulation of land use and its evolution in time. In spite of this, characterization and regulation of urban areas remains a complex process, requiring expert human intervention, analysis and judgment. Here we carry out a spatio-temporal fractal analysis of a metropolitan area, based on which we develop a model which generates a cartographic representation and classification of built-up areas, identifying (and even predicting) those areas requiring the most proximate planning and regulation. Furthermore, we show how different types of urban areas identified by the model co-evolve with the city, requiring policy regulation to be flexible and adaptive, acting just in time. The algorithmic implementation of the model is applicable to any built-up area and simple enough to pave the way for the automatic classification of urban areas worldwide.

  10. STRAWBERRY CRATER ROADLESS AREAS, ARIZONA.

    Science.gov (United States)

    Wolfe, Edward W.; Light, Thomas D.

    1984-01-01

    The results of a mineral survey conducted in the Strawberry Crater Roadless Areas, Arizona, indicate little promise for the occurrence of metallic mineral or fossil fuel resources in the area. The area contains deposits of cinder, useful for the production of aggregate block, and for deposits of decorative stone; however, similar deposits occur in great abundance throughout the San Francisco volcanic field outside the roadless areas. There is a possibility that the Strawberry Crater Roadless Areas may overlie part of a crustal magma chamber or still warm pluton related to the San Francisco Mountain stratovolcano or to basaltic vents of late Pleistocene or Holocene age. Such a magma chamber or pluton beneath the Strawberry Crater Roadless Areas might be an energy source from which a hot-, dry-rock geothermal energy system could be developed, and a probable geothermal resource potential is therefore assigned to these areas. 9 refs.

  11. Computer Mediated Communication: Online Instruction and Interactivity.

    Science.gov (United States)

    Lavooy, Maria J.; Newlin, Michael H.

    2003-01-01

    Explores the different forms and potential applications of computer mediated communication (CMC) for Web-based and Web-enhanced courses. Based on their experiences with three different Web courses (Research Methods in Psychology, Statistical Methods in Psychology, and Basic Learning Processes) taught repeatedly over the last five years, the…

  12. IgE-mediated food hypersensitivity disorders.

    Science.gov (United States)

    Gotua, M; Lomidze, N; Dolidze, N; Gotua, T

    2008-04-01

    Food allergy has become a serious health concern especially in developed countries in the past two decades. In general population approximately 4-6% of children and 1-3% of adults experience food allergy. The article reviews IgE-mediated food hypersensitivity disorders. Epidemiology, Mechanism, Clinical manifestations, Genetically modified crops (GMOs), Diagnosis, Prevention and Treatment of IgE-mediated food allergies are discussed. The investigations show that over 90% of IgE-mediated food allergies in childhood are caused by: cow's milk, hen's egg, soy, peanuts, tree nuts, wheat, fish and shellfish. Also the causes of food allergy are food additives, genetically modified crops. Risk factors for food-dependent exercise-induced anaphylaxis include asthma and previous allergic reactions to the causative food. Food allergy is one of the most common causes of systematic anaphylaxis and anaphylactoid reactions, with an annual incidence of four cases per million populations and estimated 500 deaths annually. In addition to gastrointestinal symptoms, individuals may experience urticaria, angioedema, atopic dermatitis, oral syndrome, asthma, rhinitis, conjunctivitis, hypotension, shock and cardiac arrhythmias, caused by the massive release of mediators from mast cells and basophiles. Diagnosis of food allergy is based on history, detailed dietary analysis, skin testing, measuring specific IgE in blood serum and challenge tests. Treatment and prevention includes: avoidance diet, application of auto-injectable epinephrine, H1 and H2 antihistamines, corticosteroids, antileukotrienes, prostaglandin synthetase inhibitors, cromolyn sodium, etc. PMID:18487689

  13. Excursion-Set-Mediated Genetic Algorithm

    Science.gov (United States)

    Noever, David; Baskaran, Subbiah

    1995-01-01

    Excursion-set-mediated genetic algorithm (ESMGA) is embodiment of method of searching for and optimizing computerized mathematical models. Incorporates powerful search and optimization techniques based on concepts analogous to natural selection and laws of genetics. In comparison with other genetic algorithms, this one achieves stronger condition for implicit parallelism. Includes three stages of operations in each cycle, analogous to biological generation.

  14. Plasmid mediated quinolone resistance in Enterobacteriaceae

    NARCIS (Netherlands)

    Veldman, K.T.

    2014-01-01

    This thesis describes the occurrence of Plasmid Mediated Quinolone Resistance (PMQR) in Salmonella and E. coli from The Netherlands and other European countries. Furthermore, the genetic background of these genes was characterized. Fluoroquinolones are widely used antibiotics in both human and veter

  15. Computer Mediated Communication (CMC e Second Life

    Directory of Open Access Journals (Sweden)

    Annalisa Boniello

    2013-03-01

    Full Text Available In questo contributo sono riportate alcune esperienze e sperimentazioni didattiche che descrivono occasioni di comunicazione formativa (Computer Mediated Communication – CMC attraverso ambienti 3D quali Second Life (SL. Sono inoltre evidenziati e descritti i principali strumenti di comunicazione in SL e il loro utilizzo.

  16. Children and TV II: Mediating the Medium.

    Science.gov (United States)

    Winick, Mariann Pezzella; Wehrenberg, Judith S.

    This guidebook focuses on the reality of children's television viewing and the possibilities open to teachers for mediating the experience to enhance children's development and enrich the school curriculum. A Piagetian framework is used to examine and structure material suitable for the classroom. Part I of the guide reviews the historic…

  17. Multiscale Simulation of Protein Mediated Membrane Remodeling

    OpenAIRE

    Ayton, Gary S.; Voth, Gregory A.

    2009-01-01

    Proteins interacting with membranes can result in substantial membrane deformations and curvatures. This effect is known in its broadest terms as membrane remodeling. This review article will survey current multiscale simulation methodologies that have been employed to examine protein-mediated membrane remodeling.

  18. Teaching Responsibly with Technology-Mediated Communication

    Science.gov (United States)

    Veltsos, Jennifer R.; Veltsos, Christophe

    2010-01-01

    Technology-mediated communication, or "new media," such as blogs, Twitter, wikis, and social network sites, can be an endless source of ideas for activities or inspiration for classroom discussion. Many instructors ask students to monitor current events by following keywords and industry leaders on Twitter and reading both corporate and trade…

  19. Parental mediation of undesired advertising effects

    NARCIS (Netherlands)

    Buijzen, M.A.; Valkenburg, P.M.

    2005-01-01

    The aim of this study was to investigate the effectiveness of various types of parental mediation of 3 potentially undesired effects of television advertising. In a survey among 360 parent–child dyads with children in the 8 to 12 years age range, we investigated how different styles of advertising m

  20. Characterization of BASP1-mediated neurite outgrowth

    DEFF Research Database (Denmark)

    Korshunova, Irina; Caroni, Pico; Kolkova, Kateryna;

    2008-01-01

    The brain acid-soluble protein BASP1 (CAP-23, NAP-22) belongs to the family of growth-associated proteins, which also includes GAP-43, a protein recently shown to regulate neural cell adhesion molecule (NCAM)-mediated neurite outgrowth. Here, the effects of BASP1 overexpression were investigated ...

  1. Integrating Computer-Mediated Communication Strategy Instruction

    Science.gov (United States)

    McNeil, Levi

    2016-01-01

    Communication strategies (CSs) play important roles in resolving problematic second language interaction and facilitating language learning. While studies in face-to-face contexts demonstrate the benefits of communication strategy instruction (CSI), there have been few attempts to integrate computer-mediated communication and CSI. The study…

  2. Mapping of Immune-Mediated Disease Genes

    NARCIS (Netherlands)

    Ricaño-Ponce, Isis; Wijmenga, Cisca

    2013-01-01

    Genetic studies in immune-mediated diseases have yielded a large number of disease-associated loci. Here we review the progress being made in 12 such diseases, for which 199 independently associated non-HLA loci have been identified by genome-wide association studies since 2007. It is striking that

  3. Collaborative learning through computer-mediated argumentation

    NARCIS (Netherlands)

    Kanselaar, G.; Veerman, A.L.; Andriessen, J.E.B.

    1999-01-01

    This article reports on three studies that involved undergraduate students collaboratively working on authentic discussion tasks in synchronous and asynchronous Computer Mediated Communication systems (Netmeeting, Belvédère, Allaire Forums). The purposes of the assignments were respectively to deve

  4. Mediating Artifact in Teacher Professional Development

    Science.gov (United States)

    Svendsen, Bodil

    2015-07-01

    This article focuses on teacher professional development (TPD) in natural science through the 5E model as mediating artifact. The study was conducted in an upper secondary school, grounded in a school-based intervention research project. My contribution to the field of research on TPD is founded on the hypothesis that teachers would be best facilitated to make their practice more inquiry based if they are provided with a mediating artifact. In this study the artifact is a model 5E, which is a conceptual way of thinking, to help teachers reflect on their practice. The aim is to encourage teachers to make changes themselves, by applying extended use of inquiry into their practice. This mediated artifact could thus be used across different national contexts. The main research question is; how can the 5E model as a mediating artifact enhance TPD? The article addresses the processes of the use of the 5E model and its influence on teachers' perception of the model. This is in order for teachers to conceptualize their goals related to inquiry and scientific thinking, and to solve the problems involved in achieving those goals in their own contexts. The study concludes that, after the intervention, the teachers' approaches and strategies demonstrate greater emphasis on learning.

  5. A Mediated Lifespace: Working Relationally with Girls

    Science.gov (United States)

    Hoskins, Marie L.; Mathieson, Lindsay C.

    2004-01-01

    A lifespace has to do with how selves are mediated by combining multiple cultural symbols to construct an identity in the world. The authors cite examples from media texts, as well as from a narrative study conducted with 10 adolescent girls in a treatment program for eating disorders, that illustrate the importance of practitioners considering…

  6. Nutritionally Mediated Oxidative Stress and Inflammation

    Directory of Open Access Journals (Sweden)

    Alexandra Muñoz

    2013-01-01

    Full Text Available There are many sources of nutritionally mediated oxidative stress that trigger inflammatory cascades along short and long time frames. These events are primarily mediated via NFκB. On the short-term scale postprandial inflammation is characterized by an increase in circulating levels of IL-6 and TNF-α and is mirrored on the long-term by proinflammatory gene expression changes in the adipocytes and peripheral blood mononuclear cells (PBMCs of obese individuals. Specifically the upregulation of CCL2/MCP-1, CCL3/MIP-1α, CCL4/MIP-1β, CXCL2/MIP-2α, and CXCL3/MIP-2β is noted because these changes have been observed in both adipocytes and PBMC of obese humans. In comparing numerous human intervention studies it is clear that pro-inflammatory and anti-inflammatory consumption choices mediate gene expression in humans adipocytes and peripheral blood mononuclear cells. Arachidonic acid and saturated fatty acids (SFAs both demonstrate an ability to increase pro-inflammatory IL-8 along with numerous other inflammatory factors including IL-6, TNFα, IL-1β, and CXCL1 for arachidonic acid and IGB2 and CTSS for SFA. Antioxidant rich foods including olive oil, fruits, and vegetables all demonstrate an ability to lower levels of IL-6 in PBMCs. Thus, dietary choices play a complex role in the mediation of unavoidable oxidative stress and can serve to exacerbate or dampen the level of inflammation.

  7. Peer Mediation and Middle School Students

    Science.gov (United States)

    Calbreath, Wes; Crews, Moody E.

    2011-01-01

    With the constant concern over violence in schools, school officials are looking for ways to head off this potential problem and to better assure a safe environment for all students. One way that has become popular is the implementation of peer mediation programs where students assist other students in learning how to deal with conflict through…

  8. Comments: Causal Interpretations of Mediation Effects

    Science.gov (United States)

    Jo, Booil; Stuart, Elizabeth A.

    2012-01-01

    The authors thank Dr. Lindsay Page for providing a nice illustration of the use of the principal stratification framework to define causal effects, and a Bayesian model for effect estimation. They hope that her well-written article will help expose education researchers to these concepts and methods, and move the field of mediation analysis in…

  9. A Comparison of Three Tests of Mediation

    Science.gov (United States)

    Warbasse, Rosalia E.

    2009-01-01

    A simulation study was conducted to evaluate the performance of three tests of mediation: the bias-corrected and accelerated bootstrap (Efron & Tibshirani, 1993), the asymmetric confidence limits test (MacKinnon, 2008), and a multiple regression approach described by Kenny, Kashy, and Bolger (1998). The evolution of these methods is reviewed and…

  10. Holographic gauge mediation via strongly coupled messengers

    International Nuclear Information System (INIS)

    We consider a relative of semidirect gauge mediation where the hidden sector exists at large 't Hooft coupling. Such scenarios can be difficult to describe using perturbative field theory methods but may fall into the class of holographic gauge mediation scenarios, meaning that they are amenable to the techniques of gauge/gravity duality. We use a recently found gravity solution to examine one such case, where the hidden sector is a cascading gauge theory resulting in a confinement scale not much smaller than the messenger mass. In the original construction of holographic gauge mediation, as in other examples of semidirect gauge mediation at strong coupling, the primary contributions to visible sector soft terms come from weakly coupled messenger mesons. In contrast to these examples, we describe the dual of a gauge theory where there are significant contributions from scales in which the strongly coupled messenger quarks are the effective degrees of freedom. In this regime, the visible sector gaugino mass can be calculated entirely from holography.

  11. Computer-Mediated Communication on the Internet.

    Science.gov (United States)

    Herring, Susan C.

    2002-01-01

    This review of computer-mediated communication (CMC) on the Internet focuses on empirical research in noninstitutional and nonorganizational contexts. Highlights include modes of CMC; appropriate uses; social effects; effects on language and communication; freedom of expression; community; personal impacts; privacy; ethics; democracy;…

  12. GLI2-mediated melanoma invasion and metastasis.

    NARCIS (Netherlands)

    Alexaki, V.I.; Javelaud, D.; Kempen, L.C.L.T. van; Mohammad, K.S.; Dennler, S.; Luciani, F.; Hoek, K.S.; Juarez, P.; Goydos, J.S.; Fournier, P.J.; Sibon, C.; Bertolotto, C.; Verrecchia, F.; Saule, S.; Delmas, V.; Ballotti, R.; Larue, L.; Saiag, P.; Guise, T.A.; Mauviel, A.

    2010-01-01

    BACKGROUND: The transforming growth factor-beta (TGF-beta) pathway, which has both tumor suppressor and pro-oncogenic activities, is often constitutively active in melanoma and is a marker of poor prognosis. Recently, we identified GLI2, a mediator of the hedgehog pathway, as a transcriptional targe

  13. The detection of Plasmodiophora brassicae using loop-mediated isothermal DNA amplification

    OpenAIRE

    Joanna Kaczmarek; Witold Irzykowski; Adam Burzyński; Małgorzata Jędryczka

    2014-01-01

    Plasmodiophora brassicae, the cause of clubroot, is a very serious problem preventing from successful and profitable cultivation of oilseed rape in Poland. The pathogen was found in all main growing areas of oilseed rape; it also causes considerable problems in growing of vegetable brassicas. The aim of this work was to elaborate fast, cheap and reliable screening method to detect P. brassicae. To achieve this aim the Loop-mediated isothermal DNA amplification (LAMP) technique has been elabor...

  14. Social Communication Effects of Peer-Mediated Recess Intervention for Children with Autism

    OpenAIRE

    McFadden, Brandon; Kamps, Debra; Heitzman-Powell, Linda

    2014-01-01

    Children with ASD face enormous challenges in the area of social functioning. Research has shown that impairments in social functioning distinguish this population from both typically developing children and children with disabilities. This study incorporated several evidence-based social skills-teaching procedures (i.e., direct instruction, priming, prompting, peer-mediation, contingent reinforcement, and token economies) directly in the recess setting to increase appropriate social behavior...

  15. Immune Dysfunctlon in Patients With Obstructive Jaundice, Mediators and Implications for Treatments

    OpenAIRE

    W. G. Jiang; Puntis, M. C. A.

    1997-01-01

    Patients with obstructive jaundice have an increased perioperative complication rate. Sepsis, bleeding, wound problems, renal and liver malfunction are all seen in these patients. Assessment of immune function has been an active research area in these patients. This review will examine various aspects of immune functions in obstructive jaundice, discuss the recent research results and controversies and then go on to discuss the relevant mediators of immune function and some possible implicati...

  16. SSL Demonstration: Area Lighting, Yuma Sector Border Patrol Area, AZ

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-05-28

    Along the Yuma Sector Border Patrol Area in Yuma, Arizona, the GATEWAY program conducted a trial demonstration in which the incumbent quartz metal halide area lighting was replaced with LED at three pole locations at the Yuma Sector Border Patrol Area in Yuma, Arizona. The retrofit was documented to better understand LED technology performance in high-temperature environments. This document is a summary brief of the Phase 1.0 and 1.1 reports previously published on this demonstration.

  17. Temporal dynamics of the knowledge-mediated visual disambiguation process in humans: a magnetoencephalography study.

    Science.gov (United States)

    Urakawa, Tomokazu; Ogata, Katsuya; Kimura, Takahiro; Kume, Yuko; Tobimatsu, Shozo

    2015-01-01

    Disambiguation of a noisy visual scene with prior knowledge is an indispensable task of the visual system. To adequately adapt to a dynamically changing visual environment full of noisy visual scenes, the implementation of knowledge-mediated disambiguation in the brain is imperative and essential for proceeding as fast as possible under the limited capacity of visual image processing. However, the temporal profile of the disambiguation process has not yet been fully elucidated in the brain. The present study attempted to determine how quickly knowledge-mediated disambiguation began to proceed along visual areas after the onset of a two-tone ambiguous image using magnetoencephalography with high temporal resolution. Using the predictive coding framework, we focused on activity reduction for the two-tone ambiguous image as an index of the implementation of disambiguation. Source analysis revealed that a significant activity reduction was observed in the lateral occipital area at approximately 120 ms after the onset of the ambiguous image, but not in preceding activity (about 115 ms) in the cuneus when participants perceptually disambiguated the ambiguous image with prior knowledge. These results suggested that knowledge-mediated disambiguation may be implemented as early as approximately 120 ms following an ambiguous visual scene, at least in the lateral occipital area, and provided an insight into the temporal profile of the disambiguation process of a noisy visual scene with prior knowledge.

  18. Geographic variation and effect of area-level poverty rate on colorectal cancer screening

    Directory of Open Access Journals (Sweden)

    Schootman Mario

    2008-10-01

    Full Text Available Abstract Background With a secular trend of increasing colorectal cancer (CRC screening, concerns about disparities in CRC screening also have been rising. It is unclear if CRC screening varies geographically, if area-level poverty rate affects CRC screening, and if individual-level characteristics mediate the area-level effects on CRC screening. Methods Using 2006 Missouri Behavioral Risk Factor Surveillance System (BRFSS data, a multilevel study was conducted to examine geographic variation and the effect of area-level poverty rate on CRC screening use among persons age 50 or older. Individuals were nested within ZIP codes (ZIP5 areas, which in turn, were nested within aggregations of ZIP codes (ZIP3 areas. Six groups of individual-level covariates were considered as potential mediators. Results An estimated 51.8% of Missourians aged 50 or older adhered to CRC screening recommendations. Nearly 15% of the total variation in CRC screening lay between ZIP5 areas. Persons residing in ZIP5 areas with ≥ 10% of poverty rate had lower odds of CRC screening use than those residing in ZIP5 areas with Conclusion Large geographic variation of CRC screening exists in Missouri. Area-level poverty rate, independent of individual-level characteristics, is a significant predictor of CRC screening, but it only explains a small portion of the geographic heterogeneity of CRC screening. Individual-level factors we examined do not mediate the effect of the area-level poverty rate on CRC screening. Future studies should identify other area- and individual-level characteristics associated with CRC screening in Missouri.

  19. The Role of Cognitive Style Variables in Mediating the Influence of Aggressive Television upon Elementary School Children.

    Science.gov (United States)

    Thomas, Sally

    A study was conducted to investigate the impact which certain cognitive styles or structures have in mediating the influence of aggressive television on young boys. The subjects were 143 boys, ranging in age from 5-1/2 to 8-1/2 years, attending elementary school in the Santa Monica area. During the first of two sessions, each child was…

  20. Chinese semantic processing cerebral areas

    Institute of Scientific and Technical Information of China (English)

    SHAN Baoci; ZHANG Wutian; MA Lin; LI Dejun; CAO Bingli; TANG Yiyuan; WU Yigen; TANG Xiaowei

    2003-01-01

    This study has identified the active cerebral areas of normal Chinese that are associated with Chinese semantic processing using functional brain imaging. According to the traditional cognitive theory, semantic processing is not particularly associated with or affected by input modality. The functional brain imaging experiments were conducted to identify the common active areas of two modalities when subjects perform Chinese semantic tasks through reading and listening respectively. The result has shown that the common active areas include left inferior frontal gyrus (BA 44/45), left posterior inferior temporal gyrus (BA37); the joint area of inferior parietal lobules (BA40) and superior temporal gyrus, the ventral occipital areas and cerebella of both hemispheres. It gives important clue to further discerning the roles of different cerebral areas in Chinese semantic processing.

  1. LOST CREEK ROADLESS AREA, CALIFORNIA.

    Science.gov (United States)

    Muffler, L.J. Patrick; Campbell, Harry W.

    1984-01-01

    Geologic and mineral-resource investigations identified no mineral-resource potential in the Lost Creek Roadless Area, California. Sand and gravel have been mined from alluvial flood-plain deposits less than 1 mi outside the roadless area; these deposits are likely to extend into the roadless area beneath a Holocene basalt flow that may be as much as 40 ft thick. An oil and gas lease application which includes the eastern portion of the roadless area is pending. Abundant basalt in the area can be crushed and used as aggregate, but similar deposits of volcanic cinders or sand and gravel in more favorable locations are available outside the roadless area closer to major markets. No indication of coal or geothermal energy resources was identified.

  2. SYCAMORE CANYON PRIMITIVE AREA, ARIZONA.

    Science.gov (United States)

    Huff, Lyman C.; Raabe, R.C.

    1984-01-01

    The Sycamore Canyon Primitive Area, which occupies about 74 sq mi, lies about 24 mi southwest of Flagstaff, Arizona. To help evaluate the area for mineral resources, sediment samples were collected along Sycamore Creek and its tributaries. These were analyzed for traces of the ore metals without finding any local concentrations. In addition, a scintillometer was used to test rocks in the area without finding any abnormal radioactivity.

  3. Pollen- and seed-mediated transgene flow in commercial cotton seed production fields.

    Directory of Open Access Journals (Sweden)

    Shannon Heuberger

    Full Text Available BACKGROUND: Characterizing the spatial patterns of gene flow from transgenic crops is challenging, making it difficult to design containment strategies for markets that regulate the adventitious presence of transgenes. Insecticidal Bacillus thuringiensis (Bt cotton is planted on millions of hectares annually and is a potential source of transgene flow. METHODOLOGY/PRINCIPAL FINDINGS: Here we monitored 15 non-Bt cotton (Gossypium hirsutum, L. seed production fields (some transgenic for herbicide resistance, some not for gene flow of the Bt cotton cry1Ac transgene. We investigated seed-mediated gene flow, which yields adventitious Bt cotton plants, and pollen-mediated gene flow, which generates outcrossed seeds. A spatially-explicit statistical analysis was used to quantify the effects of nearby Bt and non-Bt cotton fields at various spatial scales, along with the effects of pollinator abundance and adventitious Bt plants in fields, on pollen-mediated gene flow. Adventitious Bt cotton plants, resulting from seed bags and planting error, comprised over 15% of plants sampled from the edges of three seed production fields. In contrast, pollen-mediated gene flow affected less than 1% of the seed sampled from field edges. Variation in outcrossing was better explained by the area of Bt cotton fields within 750 m of the seed production fields than by the area of Bt cotton within larger or smaller spatial scales. Variation in outcrossing was also positively associated with the abundance of honey bees. CONCLUSIONS/SIGNIFICANCE: A comparison of statistical methods showed that our spatially-explicit analysis was more powerful for understanding the effects of surrounding fields than customary models based on distance. Given the low rates of pollen-mediated gene flow observed in this study, we conclude that careful planting and screening of seeds could be more important than field spacing for limiting gene flow.

  4. GRANITE PEAK ROADLESS AREA, CALIFORNIA.

    Science.gov (United States)

    Huber, Donald F.; Thurber, Horace K.

    1984-01-01

    The Granite Peak Roadless Area occupies an area of about 5 sq mi in the southern part of the Trinity Alps of the Klamath Mountains, about 12 mi north-northeast of Weaverville, California. Rock and stream-sediment samples were analyzed. All streams draining the roadless area were sampled and representative samples of the rock types in the area were collected. Background values were established for each element and anomalous values were examined within their geologic settings and evaluated for their significance. On the basis of mineral surveys there seems little likelihood for the occurrence of mineral or energy resources.

  5. Small Engine & Accessory Test Area

    Data.gov (United States)

    Federal Laboratory Consortium — The Small Engine and Accessories Test Area (SEATA) facilitates testaircraft starting and auxiliary power systems, small engines and accessories. The SEATA consists...

  6. Experiences with peer mediation on selected primary schools

    OpenAIRE

    Rugelj, Darja

    2011-01-01

    Peer mediation, as an efficient way of confict resolution in primary school, is presented in this diploma paper. The theoretical part exposes the question of education, educational plan, mediation in general, peer mediation and serves as a ground to the empirical research. The purpose of this diploma paper is, first with with theoretical examination of the chosen subject and later with independent research, to determine the frequency of referencing of peer mediation as a proactive and prevent...

  7. Workplace Mediation in Ireland: Bridging the Research-Practice Gap

    OpenAIRE

    Curran, Deridre

    2015-01-01

    The purpose of this article is to present a case for the importance of research in informing mediation practice specifically in the context of the management of workplace conflict in Ireland. The position of mediation within the broader dispute-resolution framework is clarified at the outset and the core mediation process is described. The increasing use of mediation in Ireland and the changing institutional context within which it is conducted are discussed. The importance of research is str...

  8. Runoff estimation in residencial area

    Directory of Open Access Journals (Sweden)

    Meire Regina de Almeida Siqueira

    2013-12-01

    Full Text Available This study aimed to estimate the watershed runoff caused by extreme events that often result in the flooding of urban areas. The runoff of a residential area in the city of Guaratinguetá, São Paulo, Brazil was estimated using the Curve-Number method proposed by USDA-NRCS. The study also investigated current land use and land cover conditions, impermeable areas with pasture and indications of the reforestation of those areas. Maps and satellite images of Residential Riverside I Neighborhood were used to characterize the area. In addition to characterizing land use and land cover, the definition of the soil type infiltration capacity, the maximum local rainfall, and the type and quality of the drainage system were also investigated. The study showed that this neighborhood, developed in 1974, has an area of 792,700 m², a population of 1361 inhabitants, and a sloping area covered with degraded pasture (Guaratinguetá-Piagui Peak located in front of the residential area. The residential area is located in a flat area near the Paraiba do Sul River, and has a poor drainage system with concrete pipes, mostly 0.60 m in diameter, with several openings that capture water and sediments from the adjacent sloping area. The Low Impact Development (LID system appears to be a viable solution for this neighborhood drainage system. It can be concluded that the drainage system of the Guaratinguetá Riverside I Neighborhood has all of the conditions and characteristics that make it suitable for the implementation of a low impact urban drainage system. Reforestation of Guaratinguetá-Piagui Peak can reduce the basin’s runoff by 50% and minimize flooding problems in the Beira Rio neighborhood.

  9. Organizational mediators siding with or against the powerful party?

    NARCIS (Netherlands)

    C.K.W. de Dreu; P. Laskewitz; E. van de Vliert

    1994-01-01

    Examined whether, instead of being impartial, a mediator may side with one party as a function of the disputants' power differences (power balancing theory), the mediator's legitimacy judgments (siding theory), or the disputants' capacity to sanction the mediator (siding theory). A questionnaire stu

  10. 75 FR 52054 - Assessment of Mediation and Arbitration Procedures

    Science.gov (United States)

    2010-08-24

    ... Surface Transportation Board Assessment of Mediation and Arbitration Procedures AGENCY: Surface... matters relating to the use of mediation and arbitration as effective means of resolving disputes that are... mediation and arbitration in the resolution of disputes. If so, the proposed changes or new rules would...

  11. Conflict Resolution and Peer Mediation: Pathways to Safer Schools.

    Science.gov (United States)

    Stomfay-Stitz, Aline M.

    1994-01-01

    Defines conflict resolution and peer mediation and reviews the theoretical base for conflict resolution research. Examines the goals and activities of several peer mediation programs, and discusses the benefits of such programs. Notes that conflict resolution and peer mediation offer feasible opportunities for an entire school community to create…

  12. 29 CFR 1202.2 - Interpretation of mediation agreements.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Interpretation of mediation agreements. 1202.2 Section 1202.2 Labor Regulations Relating to Labor (Continued) NATIONAL MEDIATION BOARD RULES OF PROCEDURE § 1202.2 Interpretation of mediation agreements. Under section 5, Second, of title I of the Railway...

  13. 40 CFR 7.180 - Mediation of age discrimination complaints.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Mediation of age discrimination... Discrimination Prohibited on the Basis of Age § 7.180 Mediation of age discrimination complaints. (a) The OCR will refer all accepted complaints alleging age discrimination to the Mediation Agency designated...

  14. 29 CFR 1203.3 - Interpretation of mediation agreements.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Interpretation of mediation agreements. 1203.3 Section 1203.3 Labor Regulations Relating to Labor (Continued) NATIONAL MEDIATION BOARD APPLICATIONS FOR SERVICE § 1203.3 Interpretation of mediation agreements. (a) Applications may be filed with the Board's Chief...

  15. The Use of Propensity Scores in Mediation Analysis

    Science.gov (United States)

    Jo, Booil; Stuart, Elizabeth A.; MacKinnon, David P.; Vinokur, Amiram D.

    2011-01-01

    Mediation analysis uses measures of hypothesized mediating variables to test theory for how a treatment achieves effects on outcomes and to improve subsequent treatments by identifying the most efficient treatment components. Most current mediation analysis methods rely on untested distributional and functional form assumptions for valid…

  16. 7 CFR 900.103 - Application for mediation.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Application for mediation. 900.103 Section 900.103 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... Application for mediation. An application for mediation by a cooperative, shall be in writing and...

  17. 45 CFR 400.83 - Mediation and fair hearings.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Mediation and fair hearings. 400.83 Section 400.83... Employment § 400.83 Mediation and fair hearings. (a) Mediation—(1) Public/private RCA program. The State must ensure that a mediation period prior to imposition of sanctions is provided to refugees by...

  18. 15 CFR 930.112 - Request for Secretarial mediation.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Request for Secretarial mediation. 930... RESOURCE MANAGEMENT FEDERAL CONSISTENCY WITH APPROVED COASTAL MANAGEMENT PROGRAMS Secretarial Mediation § 930.112 Request for Secretarial mediation. (a) The Secretary or other head of a Federal agency, or...

  19. 15 CFR 930.114 - Secretarial mediation efforts.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Secretarial mediation efforts. 930.114... MANAGEMENT FEDERAL CONSISTENCY WITH APPROVED COASTAL MANAGEMENT PROGRAMS Secretarial Mediation § 930.114 Secretarial mediation efforts. (a) Following the close of the hearing, the hearing officer shall transmit...

  20. Mediation: An Emerging Form of Dispute Resolution on College Campuses.

    Science.gov (United States)

    Hayes, James A.; Balogh, Cynthia P.

    1990-01-01

    Surveyed National Association of Student Personnel Administrators member institutions (N=704) to determine existence and characteristics of student affairs mediation programs. Found 29 campuses had established formal mediation programs. Argues that establishing formal mediation programs provides many institutional benefits. (Author/CM)

  1. A Modest Proposal: Mediating IDEA Disputes Without Splitting the Baby.

    Science.gov (United States)

    Beyer, Jonathan A.

    1999-01-01

    Recognizes the benefits of mediation for easing special education conflicts, but addresses the inconsistencies and ambiguities created by the 1997 amendments to the Individuals with Disabilities Education Act (IDEA). Recommends that state and local education agencies use mediators certified in sophisticated mediation techniques, schooled in…

  2. Mediation in civiele en bestuursrechtelijke zaken: Een internationaal literatuuronderzoek

    OpenAIRE

    Baas, N.

    2002-01-01

    Doel van dit onderzoek is een overzicht krijgen van vormen van mediation van civiel- en bestuursrechtelijke zaken in binnen- en buitenland, de effectiviteit en efficientie van mediation-projecten en de factoren die van invloed zijn op de effectiviteit en efficiency van mediation.

  3. Coagulation and Placenta-Mediated Complications

    Directory of Open Access Journals (Sweden)

    Anat Aharon

    2014-10-01

    Full Text Available Pregnancy is a physiological hypercoagulable state, preparing the mother for the hemostatic challenge of delivery. However, this is associated with an increased risk of venous thrombosis and placenta-mediated complications, which present major challenges for mother and fetus. Although these conditions are heterogeneous in their pathophysiology, hereditary and acquired thrombophilia has been associated with recurrent pregnancy loss and gestational vascular complications, such as early-onset pre-eclampsia and placental abruption. Prevention of such placenta-mediated complications, which collectively complicate up to 15% of pregnancies, is a major issue for women’s health. Prospective interventional studies stratified by current knowledge of pathophysiological mechanisms related to placental and systemic hemostatic alterations will impact on the management of pregnancies at risk of these complications.

  4. Mediated Trust in the Innovation Ecosystem

    DEFF Research Database (Denmark)

    Mogensen, Kirsten

    besides industry, state and academia. In this paper, the concept mediated trust refers to the process in which an independent institution produces a form of mass medium. As is the case with any message, the content of the mass media is coded so that it signals to what degree information and/or opinions......This paper introduces a framework for further studies in the role of mediated trust in the innovation ecosystems. Combining insight from scholars like Etzkowitz, Russel and Nordfors, the concept of innovation ecosystem is described as an extended Triple Helix where media is seen as a fourth strand...... should be considered trustworthy. When receiving the message, the audience will decode the signals. Trust is considered fundamental for mass media if these are to fulfill their normative functions in the innovation ecosystem. However, the concept of trust is not clearly defined in the literature and we...

  5. Supersymmetry Breaking, Gauge Mediation, and the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Shih, David [Rutgers Univ., New Brunswick, NJ (United States)

    2015-04-14

    Gauge mediated SUSY breaking (GMSB) is a promising class of supersymmetric models that automatically satisfies the precision constraints. Prior work of Meade, Seiberg and Shih in 2008 established the full, model-independent parameter space of GMSB, which they called "General Gauge Mediation" (GGM). During the first half of 2010-2015, Shih and his collaborators thoroughly explored the parameter space of GGM and established many well-motivated benchmark models for use by the experimentalists at the LHC. Through their work, the current constraints on GGM from LEP, the Tevatron and the LHC were fully elucidated, together with the possible collider signatures of GMSB at the LHC. This ensured that the full discovery potential for GGM could be completely realized at the LHC.

  6. The Maieutic Force of Mediating Instruments

    DEFF Research Database (Denmark)

    Revellino, Silvana; Mouritsen, Jan

    which leads multiple and dispersed actors to compromising on the investment project. In these compromising spaces, which enable questioning to emerge, disagreements and controversies are temporarily appeased even in the absence of an interest alignment. The mediating properties of the Chronoprogram...... transform actions in unexpected directions which reconfigure the capital budgeting complex investment project and also extend the motorway object. The paper thus further develops the notion of mediating instruments by highlighting their maieutic ability to address the dialectics between matters of fact......This paper investigates how compromising plays a role when framing, developing and appraising capital budgeting projects. Motivated by Miller & O’Leary’s (1997, 2005a, 2005b, 2007) call for further research on capital budgeting to include not only valuation practices but also practices for managing...

  7. General Gauge Mediation with Gauge Messengers

    CERN Document Server

    Intriligator, Kenneth

    2010-01-01

    We generalize the General Gauge Mediation formalism to allow for the possibility of gauge messengers. Gauge messengers occur when charged matter fields of the susy-breaking sector have non-zero F-terms, which leads to tree-level, susy-breaking mass splittings in the gauge fields. A classic example is that SU(5) / SU(3) x SU(2) x U(1) gauge fields could be gauge messengers. We give a completely general, model independent, current-algebra based analysis of gauge messenger mediation of susy-breaking to the visible sector. Characteristic aspects of gauge messengers include enhanced contributions to gaugino masses, (tachyonic) sfermion mass-squareds generated already at one loop, and also at two loops, and significant one-loop A-terms, already at the messenger scale.

  8. Supersymmetry Breaking, Gauge Mediation, and the LHC

    International Nuclear Information System (INIS)

    Gauge mediated SUSY breaking (GMSB) is a promising class of supersymmetric models that automatically satisfies the precision constraints. Prior work of Meade, Seiberg and Shih in 2008 established the full, model-independent parameter space of GMSB, which they called 'General Gauge Mediation' (GGM). During the first half of 2010-2015, Shih and his collaborators thoroughly explored the parameter space of GGM and established many well-motivated benchmark models for use by the experimentalists at the LHC. Through their work, the current constraints on GGM from LEP, the Tevatron and the LHC were fully elucidated, together with the possible collider signatures of GMSB at the LHC. This ensured that the full discovery potential for GGM could be completely realized at the LHC.

  9. Lignin biodegradation with laccase-mediator systems

    Directory of Open Access Journals (Sweden)

    Lew Paul Christopher

    2014-03-01

    Full Text Available Lignin has a significant and largely unrealized potential as a source for the sustainable production of fuels and bulk high-value chemicals. It can replace fossil-based oil as a renewable feedstock that would bring about socio-economic and environmental benefits in our transition to a biobased economy. The efficient utilization of lignin however requires its depolymerization to low molecular weight phenolics and aromatics that can then serve as the building blocks for chemical syntheses of high-value products. The ability of laccase to attack and degrade lignin in conjunction with laccase mediators is currently viewed as one of the potential breakthrough applications for lignin valorization. Here we review the recent progress in lignin biodegradation with laccase-mediator systems, and research needs that need to be addressed in this field.

  10. CEACAM1-Mediated Inhibition of Virus Production.

    Science.gov (United States)

    Vitenshtein, Alon; Weisblum, Yiska; Hauka, Sebastian; Halenius, Anne; Oiknine-Djian, Esther; Tsukerman, Pinchas; Bauman, Yoav; Bar-On, Yotam; Stern-Ginossar, Noam; Enk, Jonatan; Ortenberg, Rona; Tai, Julie; Markel, Gal; Blumberg, Richard S; Hengel, Hartmut; Jonjic, Stipan; Wolf, Dana G; Adler, Heiko; Kammerer, Robert; Mandelboim, Ofer

    2016-06-14

    Cells in our body can induce hundreds of antiviral genes following virus sensing, many of which remain largely uncharacterized. CEACAM1 has been previously shown to be induced by various innate systems; however, the reason for such tight integration to innate sensing systems was not apparent. Here, we show that CEACAM1 is induced following detection of HCMV and influenza viruses by their respective DNA and RNA innate sensors, IFI16 and RIG-I. This induction is mediated by IRF3, which bound to an ISRE element present in the human, but not mouse, CEACAM1 promoter. Furthermore, we demonstrate that, upon induction, CEACAM1 suppresses both HCMV and influenza viruses in an SHP2-dependent process and achieves this broad antiviral efficacy by suppressing mTOR-mediated protein biosynthesis. Finally, we show that CEACAM1 also inhibits viral spread in ex vivo human decidua organ culture. PMID:27264178

  11. CEACAM1-Mediated Inhibition of Virus Production

    Directory of Open Access Journals (Sweden)

    Alon Vitenshtein

    2016-06-01

    Full Text Available Cells in our body can induce hundreds of antiviral genes following virus sensing, many of which remain largely uncharacterized. CEACAM1 has been previously shown to be induced by various innate systems; however, the reason for such tight integration to innate sensing systems was not apparent. Here, we show that CEACAM1 is induced following detection of HCMV and influenza viruses by their respective DNA and RNA innate sensors, IFI16 and RIG-I. This induction is mediated by IRF3, which bound to an ISRE element present in the human, but not mouse, CEACAM1 promoter. Furthermore, we demonstrate that, upon induction, CEACAM1 suppresses both HCMV and influenza viruses in an SHP2-dependent process and achieves this broad antiviral efficacy by suppressing mTOR-mediated protein biosynthesis. Finally, we show that CEACAM1 also inhibits viral spread in ex vivo human decidua organ culture.

  12. Seminatural Gauge Mediation from Product Group Unification

    CERN Document Server

    Fukuda, Hajime; Yanagida, Tsutomu T; Yokozaki, Norimi

    2015-01-01

    We propose a focus point gauge mediation model based on the product group unification (PGU), which solves the double-triplet splitting problem of the Higgs multiplets. In the focus point gauge mediation, the electroweak symmetry breaking scale can be naturally explained even for multi-TeV stops. It is known that the focus point behavior appears if a ratio of the number of SU(2) doublet messengers to that of SU(3) triplet messengers is close to 2.5. Importantly, this ratio (effectively) appears in our scenario based on the PGU, if the messenger field is an adjoint representation of SU(5) gauge group. Therefore, our focus point scenario is very predictive. It is also pointed out the gravitino can be dark matter without spoiling the success of the thermal leptogenesis.

  13. On messengers and metastability in gauge mediation

    International Nuclear Information System (INIS)

    One notoriously difficult problem in perturbative gauge mediation of supersymmetry breaking via messenger fields is the generic presence of a phenomenologically unacceptable vacuum with messenger vevs, with a lower energy than the desired ('MSSM') vacuum. We investigate the possibility that quantum corrections promote the latter to the ground state of the theory, and find that this is indeed feasible. For this to happen, the couplings of the messengers to the goldstino superfield must be small, and this implies an additional suppression of the MSSM soft terms with respect to the supersymmetry breaking scale. This in turn sets a lower limit on the masses of the messengers and of the supersymmetry breaking fields, which makes both sectors inaccessible at colliders. Contrary to other scenarios like direct gauge mediation, gaugino masses are unsuppressed with respect to scalar masses.

  14. Naturalness from runaways in direct mediation

    International Nuclear Information System (INIS)

    Postulating that the nonminimal supersymmetric standard model singlet is a meson of a microscopic confining theory opens up new model-building possibilities. Based on this, we construct calculable models of direct mediation that solve the μ/Bμ problem and simultaneously lead to realistic phenomenology. The singlet that couples to the Higgs fields develops a runaway produced by soft interactions and then stabilized by a small superpotential perturbation. The mechanism is first realized in an O'Raifeartaigh model of direct gauge mediation with metastable supersymmetry breaking. Focusing then on the microscopic theory, we argue that super QCD with massless and massive flavors in the free magnetic phase gives rise to this dynamics in the infrared. A deformation of the super QCD superpotential leads to large spontaneous R-symmetry breaking, gaugino masses naturally at the scale of the Higgs mass parameters, and the absence of CP violating phases.

  15. Gaseous mediators in resolution of inflammation.

    Science.gov (United States)

    Wallace, John L; Ianaro, Angela; Flannigan, Kyle L; Cirino, Giuseppe

    2015-05-01

    There are numerous gaseous substances that can act as signaling molecules, but the best characterized of these are nitric oxide, hydrogen sulfide and carbon monoxide. Each has been shown to play important roles in many physiological and pathophysiological processes. This article is focused on the effects of these gasotransmitters in the context of inflammation. There is considerable overlap in the actions of nitric oxide, hydrogen sulfide and carbon monoxide with respect to inflammation, and these mediators appear to act primarily as anti-inflammatory substances, promoting resolution of inflammatory processes. They also have protective and pro-healing effects in some tissues, such as the gastrointestinal tract and lung. Over the past two decades, significant progress has been made in the development of novel anti-inflammatory and cytoprotective drugs that release of one or more of these gaseous mediators.

  16. Tech Area II: A history

    Energy Technology Data Exchange (ETDEWEB)

    Ullrich, R. [Ktech Corp., Albuquerque, NM (United States)

    1998-07-01

    This report documents the history of the major buildings in Sandia National Laboratories` Technical Area II. It was prepared in support of the Department of Energy`s compliance with Section 106 of the National Historic Preservation Act. Technical Area II was designed and constructed in 1948 specifically for the final assembly of the non-nuclear components of nuclear weapons, and was the primary site conducting such assembly until 1952. Both the architecture and location of the oldest buildings in the area reflect their original purpose. Assembly activities continued in Area II from 1952 to 1957, but the major responsibility for this work shifted to other sites in the Atomic Energy Commission`s integrated contractor complex. Gradually, additional buildings were constructed and the original buildings were modified. After 1960, the Area`s primary purpose was the research and testing of high-explosive components for nuclear weapons. In 1994, Sandia constructed new facilities for work on high-explosive components outside of the original Area II diamond-shaped parcel. Most of the buildings in the area are vacant and Sandia has no plans to use them. They are proposed for decontamination and demolition as funding becomes available.

  17. Planning approaches for rurban areas

    DEFF Research Database (Denmark)

    Busck, Anne Gravsholt; Hidding, Marjan; Kristensen, Søren Bech Pilgaard;

    2009-01-01

    Urban growth and sprawl have long put pressure on rural areas, leading to a growing zone of ‘rurban areas' where a multitude of functions, urban or rural, compete for land. The development is acknowledged in European spatial planning documents, which also recommend common solutions. E.g. the spat......Urban growth and sprawl have long put pressure on rural areas, leading to a growing zone of ‘rurban areas' where a multitude of functions, urban or rural, compete for land. The development is acknowledged in European spatial planning documents, which also recommend common solutions. E.......g. the spatial policy discussed and recommended in the European Spatial Development Perspective (ESDP) emphasises the compact city concept, rural-urban linkages and conservation of nature and cultural heritage. This paper compares planning practice for rurban areas in three cases: Roskilde municipality (Denmark......), Staffanstorp municipality (Sweden) and Werv-area (the Netherlands). All three areas belong to the rurban zone and are selected to exemplify pro-active planning. The analysis focuses on how the concept of compact city is perceived and implemented, how rurban areas are managed in order to avoid further urban...

  18. Endopeptidase-Mediated Beta Lactam Tolerance

    OpenAIRE

    Dörr, Tobias; Davis, Brigid M.; Waldor, Matthew K.

    2015-01-01

    In many bacteria, inhibition of cell wall synthesis leads to cell death and lysis. The pathways and enzymes that mediate cell lysis after exposure to cell wall-acting antibiotics (e.g. beta lactams) are incompletely understood, but the activities of enzymes that degrade the cell wall (‘autolysins’) are thought to be critical. Here, we report that Vibrio cholerae, the cholera pathogen, is tolerant to antibiotics targeting cell wall synthesis. In response to a wide variety of cell wall- acting ...

  19. Green oxidations with laccase-mediator systems.

    Science.gov (United States)

    Wells, A; Teria, M; Eve, T

    2006-04-01

    Laccases are oxidase enzymes produced by 'white rot' fungi as part of a complex armoury of redox enzymes used to break down lignin--part of the carbon cycle of nature. Laccases alone or in combination with redox co-catalysts have been shown to oxidize xenobiotic compounds under conditions that can be described as 'green'. This paper describes some novel oxidations using the laccase-mediator method and some current limitations to the use of this technology. PMID:16545100

  20. Openings in technology-mediated business meetings

    OpenAIRE

    Oittinen, Tuire; Piirainen-Marsh, Arja

    2015-01-01

    The prerequisites for opening a meeting, or beginning any kind of interaction for that matter, are participants’ presence and shared orientation towards the situation at hand. This paper analyses how the initial moments of technology-mediated business meetings involving distributed work groups are organized sequentially and multimodally. Drawing on video-recorded meetings in an international company, it documents the multimodal practices used in the process of establishing co-orientation to t...

  1. Mediators of heightened pressor responses to phenylephrine

    OpenAIRE

    Thomas, KaMala S.

    2007-01-01

    This study examined whether individual and neighborhood socioeconomic status (SES) relate to vascular reactivity to phenylephrine (PE) in 105 African-Americans and 106 Caucasian-Americans. Aim 1 examined whether SES mediates the relationship between ethnicity and pressor responsiveness to PE. Aim 2 examined how neighborhood SES and individual SES relate to pressor responsiveness to PE using multilevel modeling. Aim 3 tested the hypothesis that SES moderates the relationship between perceived ...

  2. Flavour Violation in Anomaly Mediated Supersymmetry Breaking

    OpenAIRE

    Allanach, B. C.; Hiller, G; Jones, D. R. T.; Slavich, P.(LPTHE, UPMC Univ. Paris 06, Sorbonne Universités, 4 Place Jussieu, 75252, Paris, France)

    2009-01-01

    32 pages, 8 figures International audience We study squark flavour violation in the anomaly mediated supersymmetry broken (AMSB) minimal supersymmetric standard model. Analytical expressions for the three-generational squark mass matrices are derived. We show that the anomaly-induced soft breaking terms have a decreasing amount of squark flavour violation when running from the GUT to the weak scale. Taking into account inter-generational squark mixing, we work out non-trivial constraint...

  3. Behaviorally Mediated Larval Transport in Upwelling Systems

    OpenAIRE

    Morgan, Steven G.

    2014-01-01

    Highly advective upwelling systems along the western margins of continents are widely believed to transport larvae far offshore in surface currents resulting in larval wastage, limited recruitment, and increased population connectivity. However, suites of larval behaviors effectively mediate interspecific differences in the extent of cross-shelf migrations between nearshore adult habitats and offshore larval habitats. Interspecific differences in behavior determining whether larvae complete d...

  4. Cytokine-mediated reversal of multidrug resistance

    OpenAIRE

    Stein, Ulrike; Walther, Wolfgang

    1998-01-01

    The occurrence of the multidrug resistance phenotype still represents a limiting factor for successful cancer chemotherapy. Numerous efforts have been made to develop strategies for reversal and/or modulation of this major therapy obstacle through targeting at different levels of intervention. The phenomenon of MDR is often associated with overexpression of resistance-associated genes. Since the classical type of MDR in human cancers is mainly mediated by the P-glycoprotein encoded by the mul...

  5. USE OF THE PICNIC AREA

    CERN Multimedia

    Relations with the Host States Service

    2001-01-01

    On the Prévessin site CERN has provided a picnic area which is available for use by persons working on its site subject to prior reservation. The person in charge of this picnic area is Mr Yves CHEVRET ST/TFM. Following a fresh outbreak of incidents (damage to CERN equipment and to trees and plants, privately owned sheep killed or maimed by dogs belonging to users of the picnic area, etc.),   The following measures have been taken: a report on the state of the picnic area will be drawn up before and after use, the cost of any damage noted will be borne by the person making the reservation, dogs and other domestic animals are strictly forbidden in the picnic area.

  6. Geometry of Area Without Length

    CERN Document Server

    Ho, Pei-Ming

    2015-01-01

    To define a free string by the Nambu-Goto action, all we need is the notion of area, and mathematically the area can be defined directly in the absence of a metric. Motivated by the possibility that string theory admits backgrounds where the notion of length is not well defined but a definition of area is given, we study space-time geometries based on the generalization of metric to area metric. In analogy with Riemannian geometry, we define the analogues of connections, curvatures and Einstein tensor. We propose a formulation generalizing Einstein's theory that will be useful if at a certain stage or a certain scale the metric is ill-defined and the space-time is better characterized by the notion of area. Static spherical solutions are found for the generalized Einstein equation in vacuum, including the Schwarzschild solution as a special case.

  7. Geometry of area without length

    Science.gov (United States)

    Ho, Pei-Ming; Inami, Takeo

    2016-01-01

    To define a free string by the Nambu-Goto action, all we need is the notion of area, and mathematically the area can be defined directly in the absence of a metric. Motivated by the possibility that string theory admits backgrounds where the notion of length is not well defined but a definition of area is given, we study space-time geometries based on the generalization of a metric to an area metric. In analogy with Riemannian geometry, we define the analogues of connections, curvatures, and Einstein tensor. We propose a formulation generalizing Einstein's theory that will be useful if at a certain stage or a certain scale the metric is ill defined and the space-time is better characterized by the notion of area. Static spherical solutions are found for the generalized Einstein equation in vacuum, including the Schwarzschild solution as a special case.

  8. Model analysis of fomite mediated influenza transmission.

    Directory of Open Access Journals (Sweden)

    Jijun Zhao

    Full Text Available Fomites involved in influenza transmission are either hand- or droplet-contaminated. We evaluated the interactions of fomite characteristics and human behaviors affecting these routes using an Environmental Infection Transmission System (EITS model by comparing the basic reproduction numbers (R(0 for different fomite mediated transmission pathways. Fomites classified as large versus small surface sizes (reflecting high versus low droplet contamination levels and high versus low touching frequency have important differences. For example, 1 the highly touched large surface fomite (public tables has the highest transmission potential and generally strongest control measure effects; 2 transmission from droplet-contaminated routes exceed those from hand-contaminated routes except for highly touched small surface fomites such as door knob handles; and 3 covering a cough using the upper arm or using tissues effectively removes virus from the system and thus decreases total fomite transmission. Because covering a cough by hands diverts pathogens from the droplet-fomite route to the hand-fomite route, this has the potential to increase total fomite transmission for highly touched small surface fomites. An improved understanding and more refined data related to fomite mediated transmission routes will help inform intervention strategies for influenza and other pathogens that are mediated through the environment.

  9. Model analysis of fomite mediated influenza transmission.

    Science.gov (United States)

    Zhao, Jijun; Eisenberg, Joseph E; Spicknall, Ian H; Li, Sheng; Koopman, James S

    2012-01-01

    Fomites involved in influenza transmission are either hand- or droplet-contaminated. We evaluated the interactions of fomite characteristics and human behaviors affecting these routes using an Environmental Infection Transmission System (EITS) model by comparing the basic reproduction numbers (R(0)) for different fomite mediated transmission pathways. Fomites classified as large versus small surface sizes (reflecting high versus low droplet contamination levels) and high versus low touching frequency have important differences. For example, 1) the highly touched large surface fomite (public tables) has the highest transmission potential and generally strongest control measure effects; 2) transmission from droplet-contaminated routes exceed those from hand-contaminated routes except for highly touched small surface fomites such as door knob handles; and 3) covering a cough using the upper arm or using tissues effectively removes virus from the system and thus decreases total fomite transmission. Because covering a cough by hands diverts pathogens from the droplet-fomite route to the hand-fomite route, this has the potential to increase total fomite transmission for highly touched small surface fomites. An improved understanding and more refined data related to fomite mediated transmission routes will help inform intervention strategies for influenza and other pathogens that are mediated through the environment.

  10. Viable Gravity-Mediated Supersymmetry Breaking

    CERN Document Server

    Kribs, Graham D; Roy, Tuhin S

    2010-01-01

    We present a complete, viable model of gravity-mediated supersymmetry breaking that is safe from all flavor constraints. The central new idea is to employ a supersymmetry breaking sector without singlets, but with D-terms comparable to F-terms, causing supersymmetry breaking to be dominantly communicated through U(1)_R-symmetric operators. We construct a visible sector that is an extension of the MSSM where an \\emph{accidental} U(1)_R symmetry emerges naturally. Gauginos acquire Dirac masses from gravity-mediated D-terms, and tiny Majorana masses from anomaly-mediated contributions. Contributions to soft breaking scalar (mass)^2 arise from flavor-arbitrary gravity-induced F-terms plus one-loop finite flavor-blind contributions from Dirac gaugino masses. Renormalization group evolution of the gluino causes it to naturally increase nearly an order of magnitude larger than the squark masses. This hierarchy, combined with an accidentially U(1)_R-symmetric visible sector, nearly eliminates all flavor violation con...

  11. Lithium-mediated protection against ethanol neurotoxicity

    Directory of Open Access Journals (Sweden)

    Jia Luo

    2010-06-01

    Full Text Available Lithium has long been used as a mood stabilizer in the treatment of manic-depressive (bipolar disorder. Recent studies suggest that lithium has neuroprotective properties and may be useful in the treatment of acute brain injuries such as ischemia and chronic neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis. One of the most important neuroprotective properties of lithium is its anti-apoptotic action. Ethanol is a neuroteratogen and fetal alcohol spectrum disorders (FASD are caused by maternal ethanol exposure during pregnancy. FASD is the leading cause of mental retardation. Ethanol exposure causes neuroapoptosis in the developing brain. Ethanol-induced loss of neurons in the central nervous system underlies many of the behavioral deficits observed in FASD. Excessive alcohol consumption is also associated with Wernicke–Korsakoff syndrome and neurodegeneration in the adult brain. Recent in vivo and in vitro studies indicate that lithium is able to ameliorate ethanol-induced neuroapoptosis. Lithium is an inhibitor of glycogen synthase kinase 3 (GSK3 which has recently been identified as a mediator of ethanol neurotoxicity. Lithium’s neuroprotection may be mediated by its inhibition of GSK3. In addition, lithium also affects many other signaling proteins and pathways that regulate neuronal survival and differentiation. This review discusses the recent evidence of lithium-mediated protection against ethanol neurotoxicity and potential underlying mechanisms.

  12. ATP as a peripheral mediator of pain.

    Science.gov (United States)

    Hamilton, S G; McMahon, S B

    2000-07-01

    This article reviews the extent to which recent studies substantiate the hypothesis that ATP functions as a peripheral pain mediator. The discovery of the P2X family of ion channels (for which ATP is a ligand) and, in particular, the highly selective distribution of the P2X(3) receptor within the rat nociceptive system has inspired a variety of approaches to elucidate the potential role of ATP as a pain mediator. ATP elicits excitatory inward currents in small diameter sensory ganglion cells. These currents resemble those elicited by ATP on recombinantly expressed heteromeric P2X(2/3) channels as well as homomultimers consisting of P2X(2) and P2X(3). In vivo behavioural models have characterised the algogenic properties of ATP in normal conditions and in models of peripheral sensitisation. In humans, iontophoresis of ATP induces modest pain. In rats and humans the response is dependent on capsaicin sensitive neurons and is augmented in the presence of inflammatory mediators. Since ATP can be released in the vicinity of peripheral nociceptive terminals under a variety of conditions, there exists a purinergic chain of biological processes linking tissue damage to pain perception. The challenge remains to prove a physiological role for endogenous ATP in activating this chain of events.

  13. Endocytic pathways mediating oligomeric Aβ42 neurotoxicity

    Directory of Open Access Journals (Sweden)

    Laxton Kevin

    2010-05-01

    Full Text Available Abstract Background One pathological hallmark of Alzheimer's disease (AD is amyloid plaques, composed primarily of amyloid-β peptide (Aβ. Over-production or diminished clearance of the 42 amino acid form of Aβ (Aβ42 in the brain leads to accumulation of soluble Aβ and plaque formation. Soluble oligomeric Aβ (oAβ has recently emerged to be as a likely proximal cause of AD. Results Here we demonstrate that endocytosis is critical in mediating oAβ42-induced neurotoxicity and intraneuronal accumulation of Aβ. Inhibition of clathrin function either with a pharmacological inhibitor, knock-down of clathrin heavy chain expression, or expression of the dominant-negative mutant of clathrin-assembly protein AP180 did not block oAβ42-induced neurotoxicity or intraneuronal accumulation of Aβ. However, inhibition of dynamin and RhoA by expression of dominant negative mutants reduced neurotoxicity and intraneuronal Aβ accumulation. Pharmacologic inhibition of the dynamin-mediated endocytic pathway by genistein also reduced neurotoxicity. Conclusions These data suggest that dynamin-mediated and RhoA-regulated endocytosis are integral steps for oligomeric Aβ42-induced neurotoxicity and intraneuronal Aβ accumulation.

  14. Educational attainment, time preference, and health-related behaviors: A mediation analysis from the J-SHINE survey.

    Science.gov (United States)

    Takagi, Daisuke; Kondo, Naoki; Takada, Misato; Hashimoto, Hideki

    2016-03-01

    Evidence consistently shows that low education is associated with unhealthy behaviors. A recent study in behavioral economics argued that high time preferences - the tendency to prefer immediate gain to later reward - explain the limited self-control of individuals in making preventive health-related choices. The aim of this study was to examine the mediating effect of time preference on the associations between education and smoking, binge drinking and overweight in young and middle-aged adults living in a Japanese metropolitan area, using a quantitatively measured time discount rate. A population-based probabilistic sample of residents of 25-50 years of age living in four municipalities within Japanese metropolitan areas where economic disparity is relatively large was obtained from the Japanese Study on Stratification, Health, Income, and Neighborhood (J-SHINE). Respondents answered the questionnaire items using a computer-aided personal instrument (CAPI). Data from 3457 respondents were used in this study. Time preferences measured as categorical responses were converted into a continuous number of time discount rates by using the maximum likelihood method. Smoking habit, binge drinking, and body mass index were regressed on educational attainment with demographics and other confounders. The mediating effects of the time discount rate were examined with the bootstrapping method. Results showed that the time discount rate did not mediate the association between education and binge drinking and BMI. Even for smoking, the mediating effect of time discount rate was quite limited, indicating that the proportion of total effect of education mediated was only 4.3% for men and 3.0% for women. The results suggest that modifying time preferences through educational intervention has only limited efficacy in closing disparities in health-related behaviors, and that other mediators fostered by schooling, such as knowledge/skills, group norms and supportive peers

  15. Systematic Construction of the Mediation Mechanism of Social Contradictions in Social Transformation Period--a Case Study of Xuzhou area in the Eleventh Five-Year Plan period%社会转型期社会矛盾调处机制的系统建构--以“十一五”期间江苏徐州地区为研究场域

    Institute of Scientific and Technical Information of China (English)

    李绍伟

    2013-01-01

    “十一五”期间,江苏徐州地区经济呈跨越式发展,社会处于急剧转型时期,以经济利益矛盾为主要形态的社会矛盾显著增多,各类社会纠纷数量持续高位运行。这在全国具有一定的典型代表性。针对社会转型时期社会矛盾的主要特征,调处社会矛盾必须坚持以人为本与社会公平、利益均衡与利益共享、民主法治与安定有序、政府主导与社会合作的基本原则,建立健全社会矛盾调处的责任分担机制、源头治理机制、多元化解机制和工作运行机制,推动经济社会的和谐发展与共同进步。%During the Eleventh Five-Year Plan period ,the economic development in Xuzhou of Jiangsu shows a great-leap-forward pace ,and the society lies in the period of a sharp transformation .Social contradictions ,with the economic benefits contradiction as the main form ,are increasing significantly , and the number of various social disputes continues to run high ,w hich is the typical representative to some extent in China .With respect to the main characteristics of contradictions in social transformation , mediating the social contradictions should insist on the basic principles as follow s :people-oriented and social equity , interest balance and benefit sharing , democracy and law , stability and order , and government leading and social cooperation .T he mechanisms need to be established and improved are the mechanism of liability apportionment ,the source control mechanism ,the multiple solutions mechanism and the operating mechanism ,which will promote the harmonious development and common progress of economy and society .

  16. Are behavioral effects of early experience mediated by oxytocin?

    Directory of Open Access Journals (Sweden)

    Karen Lisa Bales

    2011-05-01

    Full Text Available Early experiences can alter adaptive emotional responses necessary for social behavior as well as physiological reactivity in the face of challenge. In the highly social prairie vole (Microtus ochrogaster, manipulations in early life or hormonal treatments specifically targeted at the neuropeptides oxytocin (OT and arginine vasopressin (AVP, have long-lasting, often sexually-dimorphic, consequences for social behavior. Here we examine the hypothesis that behavioral changes associated with differential early experience, in this case handling the family during the first week of life, may be mediated by changes in OT or AVP or their brain receptors. Four early treatment groups were used, differing only in the amount of manipulation received during the first week of life. MAN1 animals were handled once on post-natal day 1; MAN1 treatment produces a pattern of behavior usually considered typical of this species, against which other groups were compared. MAN 1-7 animals were handled once a day for post-natal days 1-7, MAN 7 animals were handled once on post-natal day 7, and MAN0 animals received no handling during the first week of life. When tested following weaning, males in groups that had received manipulation during the first few days of life (MAN1 and MAN1-7 displayed higher alloparenting than other groups. Neuroendocrine measures, including OT receptor binding and OT and AVP immunoreactivity, varied by early treatment. In brain areas including the nucleus accumbens, bed nucleus of stria terminalis and lateral septum, MAN0 females showed increased OT receptor binding. MAN1 animals also displayed higher numbers of immunoreactive OT cell bodies in the supraoptic nucleus. Taken together these findings support the broader hypothesis that experiences in the first few days of life, mediated in part by sexually-dimorphic changes in neuropeptides, especially in the receptor for OT, may have adaptive consequences for sociality and emotion regulation.

  17. Bias in Cross-Sectional Analyses of Longitudinal Mediation: Partial and Complete Mediation under an Autoregressive Model

    Science.gov (United States)

    Maxwell, Scott E.; Cole, David A.; Mitchell, Melissa A.

    2011-01-01

    Maxwell and Cole (2007) showed that cross-sectional approaches to mediation typically generate substantially biased estimates of longitudinal parameters in the special case of complete mediation. However, their results did not apply to the more typical case of partial mediation. We extend their previous work by showing that substantial bias can…

  18. Central mediators involved in the febrile response: effects of antipyretic drugs.

    Science.gov (United States)

    Zampronio, Aleksander R; Soares, Denis M; Souza, Glória E P

    2015-01-01

    Fever is a complex signal of inflammatory and infectious diseases. It is generally initiated when peripherally produced endogenous pyrogens reach areas that surround the hypothalamus. These peripheral endogenous pyrogens are cytokines that are produced by leukocytes and other cells, the most known of which are interleukin-1β, tumor necrosis factor-α, and interleukin-6. Because of the capacity of these molecules to induce their own synthesis and the synthesis of other cytokines, they can also be synthesized in the central nervous system. However, these pyrogens are not the final mediators of the febrile response. These cytokines can induce the synthesis of cyclooxygenase-2, which produces prostaglandins. These prostanoids alter hypothalamic temperature control, leading to an increase in heat production, the conservation of heat, and ultimately fever. The effect of antipyretics is based on blocking prostaglandin synthesis. In this review, we discuss recent data on the importance of prostaglandins in the febrile response, and we show that some endogenous mediators can still induce the febrile response even when known antipyretics reduce the levels of prostaglandins in the central nervous system. These studies suggest that centrally produced mediators other than prostaglandins participate in the genesis of fever. Among the most studied central mediators of fever are corticotropin-releasing factor, endothelins, chemokines, endogenous opioids, and substance P, which are discussed herein. Additionally, recent evidence suggests that these different pathways of fever induction may be activated during different pathological conditions. PMID:27227071

  19. Mediator and moderator effects in developmental and behavioral pediatric research.

    Science.gov (United States)

    Rose, Brigid M; Holmbeck, Grayson N; Coakley, Rachael Millstein; Franks, Elizabeth A

    2004-02-01

    The terms mediation and moderation are defined and clarified with particular emphasis on the role of mediational and moderational analyses in developmental and behavioral pediatric research. The article highlights the applicability of mediational and moderational analyses to longitudinal, intervention, and risk and protective factor research, and it provides basic information about how these analyses might be conducted. Also included is a discussion of various ways that both mediator and moderator variables can be incorporated into a single model. The article concludes with extended examples of both types of analyses using a longitudinal pediatric study for illustration. The article provides recommendations for applying mediational and moderational research in clinical practice.

  20. Plant Mediator complex and its critical functions in transcription regulation.

    Science.gov (United States)

    Yang, Yan; Li, Ling; Qu, Li-Jia

    2016-02-01

    The Mediator complex is an important component of the eukaryotic transcriptional machinery. As an essential link between transcription factors and RNA polymerase II, the Mediator complex transduces diverse signals to genes involved in different pathways. The plant Mediator complex was recently purified and comprises conserved and specific subunits. It functions in concert with transcription factors to modulate various responses. In this review, we summarize the recent advances in understanding the plant Mediator complex and its diverse roles in plant growth, development, defense, non-coding RNA production, response to abiotic stresses, flowering, genomic stability and metabolic homeostasis. In addition, the transcription factors interacting with the Mediator complex are also highlighted.