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Sample records for architecture exploring tumor

  1. Avionics Architecture for Exploration Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Avionics Architectures for Exploration Project team will develop a system level environment and architecture that will accommodate equipment from multiple...

  2. Epigenetic remodeling of chromatin architecture: exploring tumor differentiation therapies in mesenchymal stem cells and sarcomas.

    Science.gov (United States)

    Siddiqi, Sara; Mills, Joslyn; Matushansky, Igor

    2010-03-01

    Sarcomas are the mesenchymal-derived malignant tumors of connective tissues (e.g., fat, bone, and cartilage) presumed to arise from aberrant development or differentiation of mesenchymal stem cells (MSCs). Appropriate control of stem cell maintenance versus differentiation allows for normal connective tissue development. Current theories suggest that loss of this control--through accumulation of genetic lesions in MSCs at various points in the differentiation process--leads to development of sarcomas, including undifferentiated, high grade sarcoma tumors. The initiation of stem cell differentiation is highly associated with alteration of gene expression, which depends on chromatin remodeling. Epigenetic chromatin modifying agents have been shown to induce cancer cell differentiation and are currently being used clinically to treat cancer. This review will focus on the importance of epigenetic chromatin remodeling in the context of mesenchymal stem cells, sarcoma tumorigenesis and differentiation therapy.

  3. Exploring Enterprise Architecture Evaluation Practices

    DEFF Research Database (Denmark)

    Andersen, Peter; Carugati, Andrea; Grue Sørensen, Morten

    2015-01-01

    using empirical and practical studies. This paper presents the findings from a case study exploring how enterprise architecture (EA) evaluation takes place in practice. The aim of the case study is to explore EA evaluation from the practical view of primarily enterprise architects and project managers......EA evaluation has received very little attention in academic publications on EA. While EA evaluation to some extent has been described in the literature, the different ways of evaluating architecture have mainly used a top-down approach deriving measures from theory rather than a bottom-up approach...

  4. On the exploration of the DRISC architecture

    NARCIS (Netherlands)

    Yang, Q.

    2014-01-01

    The Dynamically-scheduled Reduced Instruction Set Computer (DRISC) architecture has been used to explore how Instruction-Level Parallelism (ILP) can be traded off against and how multithreading could be provisioned with simpler circuits to break the roof imposed by hardware complexity and power diss

  5. Functional Interface Considerations within an Exploration Life Support System Architecture

    Science.gov (United States)

    Perry, Jay L.; Sargusingh, Miriam J.; Toomarian, Nikzad

    2016-01-01

    As notional life support system (LSS) architectures are developed and evaluated, myriad options must be considered pertaining to process technologies, components, and equipment assemblies. Each option must be evaluated relative to its impact on key functional interfaces within the LSS architecture. A leading notional architecture has been developed to guide the path toward realizing future crewed space exploration goals. This architecture includes atmosphere revitalization, water recovery and management, and environmental monitoring subsystems. Guiding requirements for developing this architecture are summarized and important interfaces within the architecture are discussed. The role of environmental monitoring within the architecture is described.

  6. Avionics Architectures for Exploration: Wireless Technologies and Human Spaceflight

    Science.gov (United States)

    Goforth, Montgomery B.; Ratliff, James E.; Barton, Richard J.; Wagner, Raymond S.; Lansdowne, Chatwin

    2014-01-01

    The authors describe ongoing efforts by the Avionics Architectures for Exploration (AAE) project chartered by NASA's Advanced Exploration Systems (AES) Program to evaluate new avionics architectures and technologies, provide objective comparisons of them, and mature selected technologies for flight and for use by other AES projects. The AAE project team includes members from most NASA centers and from industry. This paper provides an overview of recent AAE efforts, with particular emphasis on the wireless technologies being evaluated under AES to support human spaceflight.

  7. Operational Concepts for a Generic Space Exploration Communication Network Architecture

    Science.gov (United States)

    Ivancic, William D.; Vaden, Karl R.; Jones, Robert E.; Roberts, Anthony M.

    2015-01-01

    This document is one of three. It describes the Operational Concept (OpsCon) for a generic space exploration communication architecture. The purpose of this particular document is to identify communication flows and data types. Two other documents accompany this document, a security policy profile and a communication architecture document. The operational concepts should be read first followed by the security policy profile and then the architecture document. The overall goal is to design a generic space exploration communication network architecture that is affordable, deployable, maintainable, securable, evolvable, reliable, and adaptable. The architecture should also require limited reconfiguration throughout system development and deployment. System deployment includes: subsystem development in a factory setting, system integration in a laboratory setting, launch preparation, launch, and deployment and operation in space.

  8. Raexplore: Enabling Rapid, Automated Architecture Exploration for Full Applications

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yao [Argonne National Lab. (ANL), Argonne, IL (United States); Balaprakash, Prasanna [Argonne National Lab. (ANL), Argonne, IL (United States); Meng, Jiayuan [Argonne National Lab. (ANL), Argonne, IL (United States); Morozov, Vitali [Argonne National Lab. (ANL), Argonne, IL (United States); Parker, Scott [Argonne National Lab. (ANL), Argonne, IL (United States); Kumaran, Kalyan [Argonne National Lab. (ANL), Argonne, IL (United States)

    2014-12-01

    We present Raexplore, a performance modeling framework for architecture exploration. Raexplore enables rapid, automated, and systematic search of architecture design space by combining hardware counter-based performance characterization and analytical performance modeling. We demonstrate Raexplore for two recent manycore processors IBM Blue- Gene/Q compute chip and Intel Xeon Phi, targeting a set of scientific applications. Our framework is able to capture complex interactions between architectural components including instruction pipeline, cache, and memory, and to achieve a 3–22% error for same-architecture and cross-architecture performance predictions. Furthermore, we apply our framework to assess the two processors, and discover and evaluate a list of architectural scaling options for future processor designs.

  9. The Evolution of Mission Architectures for Human Lunar Exploration

    Science.gov (United States)

    Everett, S. F.

    1995-01-01

    Defining transportation architectures for the human exploration of the Moon is a complex task due to the multitude of mission scenarios available. The mission transportation architecture recently proposed for the First Lunar Outpost (FLO) was not designed from carefully predetermined mission requirements and goals, but evolved from an initial set of requirements, which were continually modified as studies revealed that some early assumptions were not optimal. This paper focuses on the mission architectures proposed for FLO and investigates how these transportation architectures evolved. A comparison of the strengths and weaknesses of the three distinct mission architectures are discussed, namely (1) Lunar Orbit Rendezvous, (2) staging from the Cislunar Libration Point, and (3) direct to the lunar surface. In addition, several new and revolutionary architectures are discussed.

  10. Communication System Architecture for Planetary Exploration

    Science.gov (United States)

    Braham, Stephen P.; Alena, Richard; Gilbaugh, Bruce; Glass, Brian; Norvig, Peter (Technical Monitor)

    2001-01-01

    Future human missions to Mars will require effective communications supporting exploration activities and scientific field data collection. Constraints on cost, size, weight and power consumption for all communications equipment make optimization of these systems very important. These information and communication systems connect people and systems together into coherent teams performing the difficult and hazardous tasks inherent in planetary exploration. The communication network supporting vehicle telemetry data, mission operations, and scientific collaboration must have excellent reliability, and flexibility.

  11. Exploring Socio-material Orderings in Ethnography of Architectural Design

    DEFF Research Database (Denmark)

    Lotz, Katrine; Stang Våland, Marianne

    2012-01-01

    construction. Interested in examining how the current requirements in the field are – and can be - handled in architectural production, we aim to contribute to the ongoing development of ethnography of Architectural Design (Yaneva 2008, 2009, 2012). In our research, we focus on recent requirements...... in contemporary architectural design. We attempt to follow the actors in detail through their socio-material involvements and ‘architectural inventions’ such as visualized motives of space, materials, atmospheres, buildingparts and -components, and to explore how relations continuously tie and untie as a means......How can the socio-material assemblages involved in contemporary ‘doings of architecture’ be identified and studied? The paper discusses recent transformations within architectural design practice and the extended network of local actors and technologies mobilized in contemporary building...

  12. Security Policy for a Generic Space Exploration Communication Network Architecture

    Science.gov (United States)

    Ivancic, William D.; Sheehe, Charles J.; Vaden, Karl R.

    2016-01-01

    This document is one of three. It describes various security mechanisms and a security policy profile for a generic space-based communication architecture. Two other documents accompany this document- an Operations Concept (OpsCon) and a communication architecture document. The OpsCon should be read first followed by the security policy profile described by this document and then the architecture document. The overall goal is to design a generic space exploration communication network architecture that is affordable, deployable, maintainable, securable, evolvable, reliable, and adaptable. The architecture should also require limited reconfiguration throughout system development and deployment. System deployment includes subsystem development in a factory setting, system integration in a laboratory setting, launch preparation, launch, and deployment and operation in space.

  13. Enabling Rapid Naval Architecture Design Space Exploration

    Science.gov (United States)

    Mueller, Michael A.; Dufresne, Stephane; Balestrini-Robinson, Santiago; Mavris, Dimitri

    2011-01-01

    Well accepted conceptual ship design tools can be used to explore a design space, but more precise results can be found using detailed models in full-feature computer aided design programs. However, defining a detailed model can be a time intensive task and hence there is an incentive for time sensitive projects to use conceptual design tools to explore the design space. In this project, the combination of advanced aerospace systems design methods and an accepted conceptual design tool facilitates the creation of a tool that enables the user to not only visualize ship geometry but also determine design feasibility and estimate the performance of a design.

  14. A method for concept and technology exploration of aerospace architectures

    Science.gov (United States)

    Villeneuve, Frederic

    This dissertation presents the development of a new concept and technology exploration methodology for aerospace architectures. The methodology is based on modeling the design space by a graph, and optimizing the graph using Ant Colony Optimization. The results show that the proposed design methodology can explore more efficiently the concept and technology space of a launch vehicle architecture than traditional optimization approaches such as Genetic Algorithm and Simulated Annealing. The purpose of the method is to introduce quantitative and simultaneous exploration of concept and technology alternatives during the early phases of conceptual design. To achieve this goal, technical challenges such as expanding the size of the design space, exploring more efficiently the design options, and simultaneously considering technologies and concepts are overcome. The total number of design alternatives grows factorially with the number of concepts in the design space. Under these circumstances, the design space is difficult to explore in its totality. Considering more alternatives has been the focus of several researchers, using Genetic Algorithms and Simulated Annealing. The large number of incompatibilities between alternatives, however, limits these optimization algorithms and reduces the number of concepts or technologies that can be considered. To address these problems, a concept and technology selection methodology is developed. The methodology proposes a way to automatically generate aerospace architectures, and to model concept and technology incompatibilities by means of a graph. In conjunction with this new modeling approach, a graph-based stochastic optimization algorithm is used to efficiently explore the design space. This design methodology is applied to the simultaneous concept and technology exploration of an expendable launch vehicle architecture. This study demonstrates that the consideration of more design alternatives can help design engineers to make

  15. Exploration Space Suit Architecture: Destination Environmental-Based Technology Development

    Science.gov (United States)

    Hill, Terry R.

    2010-01-01

    This paper picks up where EVA Space Suit Architecture: Low Earth Orbit Vs. Moon Vs. Mars (Hill, Johnson, IEEEAC paper #1209) left off in the development of a space suit architecture that is modular in design and interfaces and could be reconfigured to meet the mission or during any given mission depending on the tasks or destination. This paper will walk though the continued development of a space suit system architecture, and how it should evolve to meeting the future exploration EVA needs of the United States space program. In looking forward to future US space exploration and determining how the work performed to date in the CxP and how this would map to a future space suit architecture with maximum re-use of technology and functionality, a series of thought exercises and analysis have provided a strong indication that the CxP space suit architecture is well postured to provide a viable solution for future exploration missions. Through the destination environmental analysis that is presented in this paper, the modular architecture approach provides the lowest mass, lowest mission cost for the protection of the crew given any human mission outside of low Earth orbit. Some of the studies presented here provide a look and validation of the non-environmental design drivers that will become every-increasingly important the further away from Earth humans venture and the longer they are away. Additionally, the analysis demonstrates a logical clustering of design environments that allows a very focused approach to technology prioritization, development and design that will maximize the return on investment independent of any particular program and provide architecture and design solutions for space suit systems in time or ahead of being required for any particular manned flight program in the future. The new approach to space suit design and interface definition the discussion will show how the architecture is very adaptable to programmatic and funding changes with

  16. Human Exploration of Mars Design Reference Architecture 5.0

    Science.gov (United States)

    Drake, Bret G.

    2010-01-01

    This paper provides a summary of the Mars Design Reference Architecture 5.0 (DRA 5.0), which is the latest in a series of NASA Mars reference missions. It provides a vision of one potential approach to human Mars exploration. The reference architecture provides a common framework for future planning of systems concepts, technology development, and operational testing as well as Mars robotic missions, research that is conducted on the International Space Station, and future lunar exploration missions. This summary the Mars DRA 5.0 provides an overview of the overall mission approach, surface strategy and exploration goals, as well as the key systems and challenges for the first three human missions to Mars.

  17. Comparison of Human Exploration Architecture and Campaign Approaches

    Science.gov (United States)

    Goodliff, Kandyce; Cirillo, William; Mattfeld, Bryan; Stromgren, Chel; Shyface, Hilary

    2015-01-01

    As part of an overall focus on space exploration, National Aeronautics and Space Administration (NASA) continues to evaluate potential approaches for sending humans beyond low Earth orbit (LEO). In addition, various external organizations are studying options for beyond LEO exploration. Recent studies include NASA's Evolvable Mars Campaign and Design Reference Architecture (DRA) 5.0, JPL's Minimal Mars Architecture; the Inspiration Mars mission; the Mars One campaign; and the Global Exploration Roadmap (GER). Each of these potential exploration constructs applies unique methods, architectures, and philosophies for human exploration. It is beneficial to compare potential approaches in order to better understand the range of options available for exploration. Since most of these studies were conducted independently, the approaches, ground rules, and assumptions used to conduct the analysis differ. In addition, the outputs and metrics presented for each construct differ substantially. This paper will describe the results of an effort to compare and contrast the results of these different studies under a common set of metrics. The paper will first present a summary of each of the proposed constructs, including a description of the overall approach and philosophy for exploration. Utilizing a common set of metrics for comparison, the paper will present the results of an evaluation of the potential benefits, critical challenges, and uncertainties associated with each construct. The analysis framework will include a detailed evaluation of key characteristics of each construct. These will include but are not limited to: a description of the technology and capability developments required to enable the construct and the uncertainties associated with these developments; an analysis of significant operational and programmatic risks associated with that construct; and an evaluation of the extent to which exploration is enabled by the construct, including the destinations

  18. Human Exploration of Mars Design Reference Architecture 5.0

    Science.gov (United States)

    Drake, Bret G.

    2009-01-01

    This document reviews the Design Reference Architecture (DRA) for human exploration of Mars. The DRA represents the current best strategy for human missions. The DRA is not a formal plan, but provides a vision and context to tie current systems and technology developments to potential missions to Mars, and it also serves as a benchmark against which alternative architectures can be measured. The document also reviews the objectives and products of the 2007 study that was to update NASA's human Mars mission reference architecture, assess strategic linkages between lunar and Mars strategies, develop an understanding of methods for reducing cost/risk of human missions through investment in research, technology development and synergy with other exploration plans. There is also a review of the process by which the DRA will continue to be refined. The unique capacities of human exploration is reviewed. The possible goals and objectives of the first three human missions are presented, along with the recommendation that the mission involve a long stay visiting multiple sites.The deployment strategy is outlined and diagrammed including the pre-deployment of the many of the material requirements, and a six crew travel to Mars on a six month trajectory. The predeployment and the Orion crew vehicle are shown. The ground operations requirements are also explained. Also the use of resources found on the surface of Mars is postulated. The Mars surface exploration strategy is reviewed, including the planetary protection processes that are planned. Finally a listing of the key decisions and tenets is posed.

  19. Service-Oriented Architecture for Space Exploration Robotic Rover Systems

    CERN Document Server

    Bassil, Youssef

    2012-01-01

    Currently, industrial sectors are transforming their business processes into e-services and component-based architectures to build flexible, robust, and scalable systems, and reduce integration-related maintenance and development costs. Robotics is yet another promising and fast-growing industry that deals with the creation of machines that operate in an autonomous fashion and serve for various applications including space exploration, weaponry, laboratory research, and manufacturing. It is in space exploration that the most common type of robots is the planetary rover which moves across the surface of a planet and conducts a thorough geological study of the celestial surface. This type of rover system is still ad-hoc in that it incorporates its software into its core hardware making the whole system cohesive, tightly-coupled, more susceptible to shortcomings, less flexible, hard to be scaled and maintained, and impossible to be adapted to other purposes. This paper proposes a service-oriented architecture fo...

  20. Software Architecture of Sensor Data Distribution In Planetary Exploration

    Science.gov (United States)

    Lee, Charles; Alena, Richard; Stone, Thom; Ossenfort, John; Walker, Ed; Notario, Hugo

    2006-01-01

    Data from mobile and stationary sensors will be vital in planetary surface exploration. The distribution and collection of sensor data in an ad-hoc wireless network presents a challenge. Irregular terrain, mobile nodes, new associations with access points and repeaters with stronger signals as the network reconfigures to adapt to new conditions, signal fade and hardware failures can cause: a) Data errors; b) Out of sequence packets; c) Duplicate packets; and d) Drop out periods (when node is not connected). To mitigate the effects of these impairments, a robust and reliable software architecture must be implemented. This architecture must also be tolerant of communications outages. This paper describes such a robust and reliable software infrastructure that meets the challenges of a distributed ad hoc network in a difficult environment and presents the results of actual field experiments testing the principles and actual code developed.

  1. Innovations in mission architectures for exploration beyond low Earth orbit.

    Science.gov (United States)

    Cooke, D R; Joosten, B J; Lo, M W; Ford, K M; Hansen, R J

    2003-01-01

    Through the application of advanced technologies and mission concepts, architectures for missions beyond Earth orbit have been dramatically simplified. These concepts enable a stepping stone approach to science driven; technology enabled human and robotic exploration. Numbers and masses of vehicles required are greatly reduced, yet the pursuit of a broader range of science objectives is enabled. The scope of human missions considered range from the assembly and maintenance of large aperture telescopes for emplacement at the Sun-Earth libration point L2, to human missions to asteroids, the moon and Mars. The vehicle designs are developed for proof of concept, to validate mission approaches and understand the value of new technologies. The stepping stone approach employs an incremental buildup of capabilities, which allows for future decision points on exploration objectives. It enables testing of technologies to achieve greater reliability and understanding of costs for the next steps in exploration.

  2. Advanced Sensor Platform to Evaluate Manloads For Exploration Suit Architectures

    Science.gov (United States)

    McFarland, Shane; Pierce, Gregory

    2016-01-01

    Space suit manloads are defined as the outer bounds of force that the human occupant of a suit is able to exert onto the suit during motion. They are defined on a suit-component basis as a unit of maximum force that the suit component in question must withstand without failure. Existing legacy manloads requirements are specific to the suit architecture of the EMU and were developed in an iterative fashion; however, future exploration needs dictate a new suit architecture with bearings, load paths, and entry capability not previously used in any flight suit. No capability currently exists to easily evaluate manloads imparted by a suited occupant, which would be required to develop requirements for a flight-rated design. However, sensor technology has now progressed to the point where an easily-deployable, repeatable and flexible manloads measuring technique could be developed leveraging recent advances in sensor technology. INNOVATION: This development positively impacts schedule, cost and safety risk associated with new suit exploration architectures. For a final flight design, a comprehensive and accurate man loads requirements set must be communicated to the contractor; failing that, a suit design which does not meet necessary manloads limits is prone to failure during testing or worse, during an EVA, which could cause catastrophic failure of the pressure garment posing risk to the crew. This work facilitates a viable means of developing manloads requirements using a range of human sizes & strengths. OUTCOME / RESULTS: Performed sensor market research. Highlighted three viable options (primary, secondary, and flexible packaging option). Designed/fabricated custom bracket to evaluate primary option on a single suit axial. Manned suited manload testing completed and general approach verified.

  3. Exploration Clinical Decision Support System: Medical Data Architecture

    Science.gov (United States)

    Lindsey, Tony; Shetye, Sandeep; Shaw, Tianna (Editor)

    2016-01-01

    The Exploration Clinical Decision Support (ECDS) System project is intended to enhance the Exploration Medical Capability (ExMC) Element for extended duration, deep-space mission planning in HRP. A major development guideline is the Risk of "Adverse Health Outcomes & Decrements in Performance due to Limitations of In-flight Medical Conditions". ECDS attempts to mitigate that Risk by providing crew-specific health information, actionable insight, crew guidance and advice based on computational algorithmic analysis. The availability of inflight health diagnostic computational methods has been identified as an essential capability for human exploration missions. Inflight electronic health data sources are often heterogeneous, and thus may be isolated or not examined as an aggregate whole. The ECDS System objective provides both a data architecture that collects and manages disparate health data, and an active knowledge system that analyzes health evidence to deliver case-specific advice. A single, cohesive space-ready decision support capability that considers all exploration clinical measurements is not commercially available at present. Hence, this Task is a newly coordinated development effort by which ECDS and its supporting data infrastructure will demonstrate the feasibility of intelligent data mining and predictive modeling as a biomedical diagnostic support mechanism on manned exploration missions. The initial step towards ground and flight demonstrations has been the research and development of both image and clinical text-based computer-aided patient diagnosis. Human anatomical images displaying abnormal/pathological features have been annotated using controlled terminology templates, marked-up, and then stored in compliance with the AIM standard. These images have been filtered and disease characterized based on machine learning of semantic and quantitative feature vectors. The next phase will evaluate disease treatment response via quantitative linear

  4. Modular production line optimization: The exPLORE architecture

    Directory of Open Access Journals (Sweden)

    Spinellis Diomidis D.

    2000-01-01

    Full Text Available The general design problem in serial production lines concerns the allocation of resources such as the number of servers, their service rates, and buffers given production-specific constraints, associated costs, and revenue projections. We describe the design of exPLOre: a modular, object-oriented, production line optimization software architecture. An abstract optimization module can be instantiated using a variety of stochastic optimization methods such as simulated annealing and genetic algorithms. Its search space is constrained by a constraint checker while its search direction is guided by a cost analyser which combines the output of a throughput evaluator with the business model. The throughput evaluator can be instantiated using Markovian, generalised queueing network methods, a decomposition, or an expansion method algorithm.

  5. Modular production line optimization: The exPLORE architecture

    Directory of Open Access Journals (Sweden)

    Diomidis D. Spinellis

    2001-01-01

    Full Text Available The general design problem in serial production lines concerns the allocation of resources such as the number of servers, their service rates, and buffers given production-specific constraints, associated costs, and revenue projections. We describe the design of exPLOre: a modular, object-oriented, production line optimization software architecture. An abstract optimization module can be instantiated using a variety of stochastic optimization methods such as simulated annealing and genetic algorithms. Its search space is constrained by a constraint checker while its search direction is guided by a cost analyser which combines the output of a throughput evaluator with the business model. The throughput evaluator can be instantiated using Markovian, generalised queueing network methods, a decomposition, or an expansion method algorithm.

  6. Dual-Use Ballute-Based Robust Aerocapture, EDL, and Surface Exploration Architecture for Effective and Distributed Exploration of Mars

    Science.gov (United States)

    Saikia, S. J.; Longuski, J. M.

    2012-06-01

    An innovative and game-changing Mars exploration mission architecture by synergizing the advantages of Inflatable Aerodynamic Decelerators, and a network of miniature space-based, aerial, surface, & subsurface exploration elements.

  7. Avionics Architectures for Exploration: Ongoing Efforts in Human Spaceflight

    Science.gov (United States)

    Goforth, Montgomery B.; Ratliff, James E.; Hames, Kevin L.; Vitalpur, Sharada V.; Woodman, Keith L.

    2014-01-01

    The field of Avionics is advancing far more rapidly in terrestrial applications than in spaceflight applications. Spaceflight Avionics are not keeping pace with expectations set by terrestrial experience, nor are they keeping pace with the need for increasingly complex automation and crew interfaces as we move beyond Low Earth Orbit. NASA must take advantage of the strides being made by both space-related and terrestrial industries to drive our development and sustaining costs down. This paper describes ongoing efforts by the Avionics Architectures for Exploration (AAE) project chartered by NASA's Advanced Exploration Systems (AES) Program to evaluate new avionic architectures and technologies, provide objective comparisons of them, and mature selected technologies for flight and for use by other AES projects. The AAE project team includes members from most NASA centers, and from industry. It is our intent to develop a common core avionic system that has standard capabilities and interfaces, and contains the basic elements and functionality needed for any spacecraft. This common core will be scalable and tailored to specific missions. It will incorporate hardware and software from multiple vendors, and be upgradeable in order to infuse incremental capabilities and new technologies. It will maximize the use of reconfigurable open source software (e.g., Goddard Space Flight Center's (GSFC's) Core Flight Software (CFS)). Our long-term focus is on improving functionality, reliability, and autonomy, while reducing size, weight, and power. Where possible, we will leverage terrestrial commercial capabilities to drive down development and sustaining costs. We will select promising technologies for evaluation, compare them in an objective manner, and mature them to be available for future programs. The remainder of this paper describes our approach, technical areas of emphasis, integrated test experience and results as of mid-2014, and future plans. As a part of the AES

  8. Systems budgets architecture and development for the Maunakea Spectroscopic Explorer

    Science.gov (United States)

    Mignot, Shan; Flagey, Nicolas; Szeto, Kei; Murowinski, Rick; McConnachie, Alan

    2016-08-01

    The Maunakea Spectroscopic Explorer (MSE) project is an enterprise to upgrade the existing Canada-France- Hawaii observatory into a spectroscopic facility based on a 10 meter-class telescope. As such, the project relies on engineering requirements not limited only to its instruments (the low, medium and high resolution spectrographs) but for the whole observatory. The science requirements, the operations concept, the project management and the applicable regulations are the basis from which these requirements are initially derived, yet they do not form hierarchies as each may serve several purposes, that is, pertain to several budgets. Completeness and consistency are hence the main systems engineering challenges for such a large project as MSE. Special attention is devoted to ensuring the traceability of requirements via parametric models, derivation documents, simulations, and finally maintaining KAOS diagrams and a database under IBM Rational DOORS linking them together. This paper will present the architecture of the main budgets under development and the associated processes, expand to highlight those that are interrelated and how the system, as a whole, is then optimized by modelling and analysis of the pertinent system parameters.

  9. Hinge Dimension: An Exploration of Enaction in Architecture

    DEFF Research Database (Denmark)

    Franinovic, Karmen; Wilson, Alexander

    2007-01-01

    In this paper, we address issues of technologically mediated enactive experience with and within architectural contexts, and the ways in which it may affect our relationships to constructed surroundings. We present the conceptual ideas and design development of the Hinge Dimension project......, an interactive architecture which is activated and transformed though the actions of its inhabitants. Changing structural, sonic and luminous arrangements continuously produce different spatial experiences as visitors move though the architecture. We summarize the results that we gathered during the public...

  10. The Exploration of Green Architecture Design Integration Teaching Mode

    Science.gov (United States)

    Shuang, Liang; Yibin, Han

    2016-01-01

    With the deepening of the concept of green building design, the course of university education gradually exposed many problems in the teaching of architectural design theory; based on the existing mode of teaching and combined with the needs of architectural design practice it proposed the "integrated" method of green building design. It…

  11. Exploring Life Support Architectures for Evolution of Deep Space Human Exploration

    Science.gov (United States)

    Anderson, Molly S.; Stambaugh, Imelda C.

    2015-01-01

    Life support system architectures for long duration space missions are often explored analytically in the human spaceflight community to find optimum solutions for mass, performance, and reliability. But in reality, many other constraints can guide the design when the life support system is examined within the context of an overall vehicle, as well as specific programmatic goals and needs. Between the end of the Constellation program and the development of the "Evolvable Mars Campaign", NASA explored a broad range of mission possibilities. Most of these missions will never be implemented but the lessons learned during these concept development phases may color and guide future analytical studies and eventual life support system architectures. This paper discusses several iterations of design studies from the life support system perspective to examine which requirements and assumptions, programmatic needs, or interfaces drive design. When doing early concept studies, many assumptions have to be made about technology and operations. Data can be pulled from a variety of sources depending on the study needs, including parametric models, historical data, new technologies, and even predictive analysis. In the end, assumptions must be made in the face of uncertainty. Some of these may introduce more risk as to whether the solution for the conceptual design study will still work when designs mature and data becomes available.

  12. On the Modern History of Passive Solar Architecture: Exploring the Paradox of Nordic Environmental Design

    DEFF Research Database (Denmark)

    Marsh, Rob

    2017-01-01

    This article examines the paradox of passive solar architecture within the Nordic context of Denmark, Norway and Sweden. Regulative developments to reduce space heating demand since the 1970s oil crisis are explored, highlighting architectural responses and the rise in prom-inence of passive solar...

  13. Convolutional Architecture Exploration for Action Recognition and Image Classification

    Science.gov (United States)

    2015-01-01

    since some of the images contain more than one class. Example classes include: airplane, bird, car . II Recognition Architecture Our action recognition... Tesla 40k, which materially limited this investigation. Not only does training take longer, less meaningful experiments can be done in the allotted time

  14. Exploration and Planning in a Three-Level Cognitive Architecture

    DEFF Research Database (Denmark)

    Kraft, Dirk; Baseski, Emre; Popovic, Mila;

    2008-01-01

    We describe an embodied cognitive system based on a three-level architecture that includes a sensorimotor layer, a mid-level layer that stores and reasons about object-action episodes, and a high-level symbolic planner that creates abstract action plans to be realised and possibly further specifi...

  15. Architectural DNA: A genetic exploration of complex structures

    NARCIS (Netherlands)

    Van Embden Andres, M.V.; Turrin, M.; Von Buelow, P.

    2011-01-01

    The approach demonstrated in this paper uses Evolutionary Computation (EC) to enhance and modify structural form based on biological micro structures.The forms are modified to conform to new boundary conditions associated with architectural structures.The process is based on a Genetic Algorithm (GA)

  16. Exploration Architecture with Quantum Inertial Gravimetry and In Situ ChipSat Sensors Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This will study an exploration architecture combining remote survey with in situ sampling, with example missions to Europa and a Near Earth Object. In particular for...

  17. Development and application of explorative tools in the field of architectural geometry: L-systems

    Directory of Open Access Journals (Sweden)

    Petruševski Ljiljana

    2010-01-01

    Full Text Available The concept of L-Systems was created as base for axiomatic theory of biologic growth. L-systems are applied in computer graphics for fractal generation, as well as in models of biological structures and simulations of their growth. Within generic architecture, by applying L-systems, the natural growth mechanisms are used as generators of architectural geometry. After mathematical and logical explanations of the chosen generic concept of L-systems, this study examines its generic potential, which is the base for development of specific explorative tools in the field of architectural geometry. Within a wider research activity titled 'Generic Explorations', the original software parametric tools have been developed, allowing generation of a complex architectural geometry based on the concept of L-systems. Variation of parametric values facilitates creation and further exploration of generated spatial forms. The paper presents possibilities of developed explorative tools, their particularities, as well as an overview of their initial application results.

  18. Adnectin CT-322 inhibits tumor growth and affects microvascular architecture and function in Colo205 tumor xenografts.

    Science.gov (United States)

    Ackermann, Maximilian; Carvajal, Irvith M; Morse, Brent A; Moreta, Miguel; O'Neil, Steven; Kossodo, Sylvie; Peterson, Jeffrey D; Delventhal, Vera; Marsh, H Nicholas; Furfine, Eric S; Konerding, Moritz A

    2011-01-01

    Antiangiogenesis has become a promising pillar in modern cancer therapy. This study investigates the antiangiogenic effects of the PEGylated Adnectin™, CT-322, in a murine Colo-205 xenograft tumor model. CT-322 specifically binds to and blocks vascular endothelial growth factor receptor (VEGFR-2). Adnectins are a novel class of targeted biologics engineered from the 10th domain of human fibronectin. CT-322 treated tumors exhibited a significant reduction in tumor growth of 69%, a 2.8 times lower tumor surface area and fewer necrotic areas. Control tumors showed a 2.36-fold higher microvessel density (MVD) and a 2.42 times higher vessel volume in corrosion casts. The vascular architecture in CT-322-treated tumors was characterized by a strong normalization of vasculature. This was quantified in corrosion casts of CT-322 treated tumors in which the intervascular distance (a reciprocal parameter indicative of vessel density) and the distance between two consecutive branchings were assessed, with these distances being 2.21 times and 2.37 times greater than in controls, respectively. Fluorescence molecular tomography (FMT) equally affirmed the inhibitory effects of CT-322 on tumor vasculature as indicated by a 60% reduction of the vascular probe, AngioSense, accumulating in tumor tissue, as a measurement of vascular permeability. Moreover, AngioSense accumulation was reduced as early as 24 h after starting treatment. The sum of these effects on tumor vasculature illustrates the anti-angiogenic mechanism underlying the antitumor activity of CT-322 and provides support for further evaluation of this Adnectin in combinatorial strategies with standard of care therapies.

  19. Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar

    Directory of Open Access Journals (Sweden)

    Camilla Matassini

    2015-12-01

    Full Text Available The synthesis of new multivalent architectures based on a trihydroxypiperidine α-fucosidase inhibitor is reported herein. Tetravalent and nonavalent dendrimers were obtained by means of the click chemistry approach involving the copper azide-alkyne-catalyzed cycloaddition (CuAAC between suitable scaffolds bearing terminal alkyne moieties and an azido-functionalized piperidine as the bioactive moiety. A preliminary biological investigation is also reported towards commercially available and human glycosidases.

  20. A model to simulate the oxygen distribution in hypoxic tumors for different vascular architectures

    Energy Technology Data Exchange (ETDEWEB)

    Espinoza, Ignacio [Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany and Department of Physics, Pontificia Universidad Católica de Chile, Santiago 7820436 (Chile); Peschke, Peter [Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg 69120 (Germany); Karger, Christian P. [Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg 69120 (Germany)

    2013-08-15

    Purpose: As hypoxic cells are more resistant to photon radiation, it is desirable to obtain information about the oxygen distribution in tumors prior to the radiation treatment. Noninvasive techniques are currently not able to provide reliable oxygenation maps with sufficient spatial resolution; therefore mathematical models may help to simulate microvascular architectures and the resulting oxygen distributions in the surrounding tissue. Here, the authors present a new computer model, which uses the vascular fraction of tumor voxels, in principle measurable noninvasively in vivo, as input parameter for simulating realistic PO2 histograms in tumors, assuming certain 3D vascular architectures.Methods: Oxygen distributions were calculated by solving a reaction-diffusion equation in a reference volume using the particle strength exchange method. Different types of vessel architectures as well as different degrees of vascular heterogeneities are considered. Two types of acute hypoxia (ischemic and hypoxemic) occurring additionally to diffusion-limited (chronic) hypoxia were implemented as well.Results: No statistically significant differences were observed when comparing 2D- and 3D-vessel architectures (p > 0.79 in all cases) and highly heterogeneously distributed linear vessels show good agreement, when comparing with published experimental intervessel distance distributions and PO2 histograms. It could be shown that, if information about additional acute hypoxia is available, its contribution to the hypoxic fraction (HF) can be simulated as well. Increases of 128% and 168% in the HF were obtained when representative cases of ischemic and hypoxemic acute hypoxia, respectively, were considered in the simulations.Conclusions: The presented model is able to simulate realistic microscopic oxygen distributions in tumors assuming reasonable vessel architectures and using the vascular fraction as macroscopic input parameter. The model may be used to generate PO2 histograms

  1. Circulating tumor cells: exploring intratumor heterogeneity of colorectal cancer.

    Science.gov (United States)

    Raimondi, Cristina; Nicolazzo, Chiara; Gradilone, Angela; Giannini, Giuseppe; De Falco, Elena; Chimenti, Isotta; Varriale, Elisa; Hauch, Siegfried; Plappert, Linda; Cortesi, Enrico; Gazzaniga, Paola

    2014-05-01

    The hypothesis of the "liquid biopsy" using circulating tumor cells (CTCs) emerged as a minimally invasive alternative to traditional tissue biopsy to determine cancer therapy. Discordance for biomarkers expression between primary tumor tissue and circulating tumor cells (CTCs) has been widely reported, thus rendering the biological characterization of CTCs an attractive tool for biomarkers assessment and treatment selection. Studies performed in metastatic colorectal cancer (mCRC) patients using CellSearch, the only FDA-cleared test for CTCs assessment, demonstrated a much lower yield of CTCs in this tumor type compared with breast and prostate cancer, both at baseline and during the course of treatment. Thus, although attractive, the possibility to use CTCs as therapy-related biomarker for colorectal cancer patients is still limited by a number of technical issues mainly due to the low sensitivity of the CellSearch method. In the present study we found a significant discordance between CellSearch and AdnaTest in the detection of CTCs from mCRC patients. We then investigated KRAS pathway activating mutations in CTCs and determined the degree of heterogeneity for KRAS oncogenic mutations between CTCs and tumor tissues. Whether KRAS gene amplification may represent an alternative pathway responsible for KRAS activation was further explored. KRAS gene amplification emerged as a functionally equivalent and mutually exclusive mechanism of KRAS pathway activation in CTCs, possibly related to transcriptional activation. The serial assessment of CTCs may represent an early biomarker of treatment response, able to overcome the intrinsic limit of current molecular biomarkers represented by intratumor heterogeneity.

  2. Autonomous Underwater Vehicle Architecture Synthesis for Shipwreck Interior Exploration

    Science.gov (United States)

    2015-12-01

    a maximum operating depth of 1000 ft. and uses a carbon dioxide scrubber that can operate for 50 hours (Nuytco 2015). The atmospheric suit...as the deep hydrothermal vents and sub-glacial lakes in Antarctica (Stone Aerospace 2010). The vehicle was designed to explore these areas for the

  3. Rule-based graph theory to enable exploration of the space system architecture design space

    Science.gov (United States)

    Arney, Dale Curtis

    The primary goal of this research is to improve upon system architecture modeling in order to enable the exploration of design space options. A system architecture is the description of the functional and physical allocation of elements and the relationships, interactions, and interfaces between those elements necessary to satisfy a set of constraints and requirements. The functional allocation defines the functions that each system (element) performs, and the physical allocation defines the systems required to meet those functions. Trading the functionality between systems leads to the architecture-level design space that is available to the system architect. The research presents a methodology that enables the modeling of complex space system architectures using a mathematical framework. To accomplish the goal of improved architecture modeling, the framework meets five goals: technical credibility, adaptability, flexibility, intuitiveness, and exhaustiveness. The framework is technically credible, in that it produces an accurate and complete representation of the system architecture under consideration. The framework is adaptable, in that it provides the ability to create user-specified locations, steady states, and functions. The framework is flexible, in that it allows the user to model system architectures to multiple destinations without changing the underlying framework. The framework is intuitive for user input while still creating a comprehensive mathematical representation that maintains the necessary information to completely model complex system architectures. Finally, the framework is exhaustive, in that it provides the ability to explore the entire system architecture design space. After an extensive search of the literature, graph theory presents a valuable mechanism for representing the flow of information or vehicles within a simple mathematical framework. Graph theory has been used in developing mathematical models of many transportation and

  4. Architectural Design Space Exploration of an FPGA-based Compressed Sampling Engine

    DEFF Research Database (Denmark)

    El-Sayed, Mohammad; Koch, Peter; Le Moullec, Yannick

    2015-01-01

    We present the architectural design space exploration of a compressed sampling engine for use in a wireless heart-rate monitoring system. We show how parallelism affects execution time at the register transfer level. Furthermore, two example solutions (modified semi-parallel and full-parallel) se......We present the architectural design space exploration of a compressed sampling engine for use in a wireless heart-rate monitoring system. We show how parallelism affects execution time at the register transfer level. Furthermore, two example solutions (modified semi-parallel and full...

  5. Exploring Textiles in Architecture through Tangible Three-Dimensional Sketching Tools

    DEFF Research Database (Denmark)

    Heimdal, Elisabeth Jacobsen; Lenau, Torben Anker; O'Mahony, Marie

    This paper argues that tangible three dimensional sketching with textiles makes it more likely that these materials will be used when creating architectural spaces. Our research contributes to the more general idea that innovation in architecture and design can be stimulated by the exploration...... of new materials. With tangible three dimensional sketching, we mean an iterative process of physical model making. In two experiments with architectural students, all textile novices, spaces were modelled using a three dimensional sketching tool consisting of textiles, cardboard support and tools...... for giving form to and joining these materials. The chosen architectural task was how textiles could be used to regulate daylight by applying them to an exterior building skin or to interior spaces. Findings were that three different strategies were used: the tool was used to materialize, illustrate...

  6. A Low Cost Spacecraft Architecture for Robotic Lunar Exploration Projects

    Science.gov (United States)

    Lemke, Lawrence G.; Gonzales, Andrew A.

    2006-01-01

    A program of frequent, capable, but affordable lunar robotic missions prior to return of humans to the moon can contribute to the Vision for Space Exploration (VSE) NASA is tasked to execute. The Lunar Reconnaissance Orbiter (LRO) and its secondary payload are scheduled to orbit the moon, and impact it, respectively, in 2008. It is expected that the sequence of missions occurring for approximately the decade after 2008 will place an increasing emphasis on soft landed payloads. These missions are requited to explore intrinsic characteristics of the moon, such as hydrogen distribution in the regolith, and levitated dust, to demonstrate the ability to access and process in-situ resources, and to demonstrate functions critical to supporting human presence, such as automated precision navigation and landing. Additional factors governing the design of spacecraft to accomplish this diverse set of objectives are: operating within a relatively modest funding profile, the need tb visit multiple sites (both polar and equatorial) repeatedly, and to use the current generation of launch vehicles. In the US, this implies use of the Evolved Expendable Launch Vehicles, or EELVs, although this design philosophy may be extended to launch vehicles of other nations, as well. Many of these factors are seemingly inconsistent with each other. For example, the cost of a spacecraft usually increases with mass; therefore the desire to fly frequent, modestly priced spacecraft seems to imply small spacecraft (autonomous navigation and soft landing) also usually increases cost. A strategy for spacecraft design that meets these conflicting requirements is presented. Taken together, spacecraft structure and propulsion subsystems constitute the majority of spacecraft mass; saving development and integration cost on these elements is critical to controlling cost. Therefore, a low cost, modular design for spacecraft structure and propulsion subsystems is presented which may be easily scaled up or

  7. Explorations in Teaching Sustainable Design: A Studio Experience in Interior Design/Architecture

    Science.gov (United States)

    Gurel, Meltem O.

    2010-01-01

    This article argues that a design studio can be a dynamic medium to explore the creative potential of the complexity of sustainability from its technological to social ends. The study seeks to determine the impact of an interior design/architecture studio experience that was initiated to teach diverse meanings of sustainability and to engage the…

  8. The Potential of Subjective Semantic Methods in Exploring the Perception of Architecture

    Directory of Open Access Journals (Sweden)

    Vyrva A.U.,

    2016-01-01

    Full Text Available This research focuses on empirical explorations of psychological features and mechanisms of the percep¬tion of urban architecture and on the specifics of the perception of buildings of various architectural styles. The techniques employed included those of personality and architectural semantic differential and the Value Spectrum technique. Four factors were found to have a significant impact on an individual’s percep¬tion and understanding of architectural space: ‘passive-active’, ‘whole-split’, ‘open-closed’, and ‘expressive’. People tend to attribute more semantic features and values to listed buildings or buildings that bear witness of a certain historical period than to those buildings that look alike and represent a typical example of mass housing. No significant sex differences were found in the individuals’ evaluations of buildings. Consistent quantitative differences were revealed between the images of listed buildings and of mass housing. The paper describes the relevance of various research methods in explorations of architectural images.

  9. Primary malignant neuroectodermal tumor of the ileum with predominantly uncommon pseudopapillary architecture.

    Science.gov (United States)

    Zhao, Zhihua; Zhang, Dandan; Li, Wencai; Zhang, Lan; Li, Zhen; Zhou, Jun

    2014-01-01

    A malignant gastrointestinal neuroectodermal tumor (GNET), a distinctive entity covering the characteristics of clear cell sarcoma (CCS) of gastrointestinal tract described recently, arising primarily in the ileum of a 33-year-old woman is reported. Histologically, the neoplasm involved the full thickness of the intestinal wall. Tumor cells, mainly displayed epithelioid or polygonal appearance with oval or round nuclei, arranged in strand, nested, and solid pattern with prominent pseudopapillary architecture instead of the familiar histological image with multinucleated osteoclast-like giant cells. They were positive for vimentin, S-100, synaptophysin, CD56 and CD99 protein, but negative for AE1/AE3, EMA, CEA, LCA, Desmin, CK7, CK20, Villin, CgA, CD117, Dog-1, GFAP, Melan-A, HMB-45, CD34, CR, WT1, D2-40. Fluorescence in situ hybridization (FISH) showed the presence of chromosomal translocation involving EWSR. The patients lived through a calm period after a tumor resection and 4 cycles of chemotherapy combining ifosfamide and epirubicin. This case demonstrates that GNET is a rare tumor in gastrointestinal tract, and furthermore, various misleading histological characteristics should been taken into consideration in the diagnosis.

  10. Avionics Architectures for Exploration: Building a Better Approach for (Human) Spaceflight Avionics

    Science.gov (United States)

    Goforth, Montgomery B.; Ratliff, James E.; Hames, Kevin L.; Vitalpur, Sharada V.

    2014-01-01

    The field of Avionics is advancing far more rapidly in terrestrial applications than in space flight applications. Spaceflight Avionics are not keeping pace with expectations set by terrestrial experience, nor are they keeping pace with the need for increasingly complex automation and crew interfaces as we move beyond Low Earth Orbit. NASA must take advantage of the strides being made by both space-related and terrestrial industries to drive our development and sustaining costs down. This paper describes ongoing efforts by the Avionics Architectures for Exploration (AAE) project chartered by NASA's Advanced Exploration Systems (AES) Program to evaluate new avionic architectures and technologies, provide objective comparisons of them, and mature selected technologies for flight and for use by other AES projects. Results from the AAE project's FY13 efforts are discussed, along with the status of FY14 efforts and future plans.

  11. Destination Deimos: A Design Reference Architecture for Initial Human Exploration of the Mars System

    Science.gov (United States)

    Logan, James S.; Adamo, D. R.

    2011-01-01

    The two biggest challenges to successful human operations in interplanetary space are flight dynamics, constrained by the cold hard physics of the rocket equation, and bioastronautics, the psychophysiological realities of human adaptation, or lack thereof, to the deep space environment. Without substantial innovation in project/mission architecture and vehicle design, human exploration of the Mars system could be problematic for decades. Although a human landing on Mars is inevitable, humans-in-the-loop telerobotic exploration from the outer Martian moon Deimos is the best way to begin. Precursor robotic missions for reconnaissance and local site preparation will be required.

  12. Human Exploration of Mars Design Reference Architecture 5.0, Addendum #2

    Science.gov (United States)

    Drake, Bret G. (Editor); Watts Kevin D. (Editor)

    2014-01-01

    This report serves as the second Addendum to NASA-SP-2009-566, "Human Exploration of Mars Design Reference Architecture 5.0." The data and descriptions contained within this Addendum capture some of the key assessments and studies produced since publication of the original document, predominately covering those conducted from 2009 through 2012. The assessments and studies described herein are for the most part independent stand-alone contributions. Effort has not been made to assimilate the findings to provide an updated integrated strategy. That is a recognized future effort. This report should not be viewed as constituting a formal plan for the human exploration of Mars.

  13. Earth Orbiting Support Systems for commercial low Earth orbit data relay: Assessing architectures through tradespace exploration

    Science.gov (United States)

    Palermo, Gianluca; Golkar, Alessandro; Gaudenzi, Paolo

    2015-06-01

    As small satellites and Sun Synchronous Earth Observation systems are assuming an increased role in nowadays space activities, including commercial investments, it is of interest to assess how infrastructures could be developed to support the development of such systems and other spacecraft that could benefit from having a data relay service in Low Earth Orbit (LEO), as opposed to traditional Geostationary relays. This paper presents a tradespace exploration study of the architecture of such LEO commercial satellite data relay systems, here defined as Earth Orbiting Support Systems (EOSS). The paper proposes a methodology to formulate architectural decisions for EOSS constellations, and enumerate the corresponding tradespace of feasible architectures. Evaluation metrics are proposed to measure benefits and costs of architectures; lastly, a multicriteria Pareto criterion is used to downselect optimal architectures for subsequent analysis. The methodology is applied to two case studies for a set of 30 and 100 customer-spacecraft respectively, representing potential markets for LEO services in Exploration, Earth Observation, Science, and CubeSats. Pareto analysis shows how increased performance of the constellation is always achieved by an increased node size, as measured by the gain of the communications antenna mounted on EOSS spacecraft. On the other hand, nonlinear trends in optimal orbital altitude, number of satellites per plane, and number of orbital planes, are found in both cases. An upward trend in individual node memory capacity is found, although never exceeding 256 Gbits of onboard memory for both cases that have been considered, assuming the availability of a polar ground station for EOSS data downlink. System architects can use the proposed methodology to identify optimal EOSS constellations for a given service pricing strategy and customer target, thus identifying alternatives for selection by decision makers.

  14. The Nomad Explorer assembly assist vehicle: An architecture for rapid global extraterrestrial base infrastructure establishment

    Science.gov (United States)

    Thangavelu, Madhu

    1994-01-01

    Traditional concepts of lunar bases describe scenarios where components of the bases are landed on the lunar surface, one at a time, and then put together to form a complete stationary lunar habitat. Recently, some concepts have described the advantages of operating a mobile or 'roving' lunar base. Such a base vastly improves the exploration range from a primary lunar base. Roving bases would also allow the crew to first deploy, test, operationally certify, and then regularly maintain, service, and evolve long life-cycle facilities like observatories or other science payload platforms that are operated far apart from each other across the extraterrestrial surface. The Nomad Explorer is such a mobile lunar base. This paper describes the architectural program of the Nomad Explorer, its advantages over a stationary lunar base, and some of the embedded system concepts which help the roving base to speedily establish a global extraterrestrial infrastructure. A number of modular autonomous logistics landers will carry deployable or erectable payloads, service, and logistically resupply the Nomad Explorer at regular intercepts along the traverse. Starting with the deployment of science experiments and telecommunication networks, and the manned emplacement of a variety of remote outposts using a unique EVA Bell system that enhances manned EVA, the Nomad Explorer architecture suggests the capability for a rapid global development of the extraterrestrial body. The Moon and Mars are candidates for this 'mission oriented' strategy. The lunar case is emphasized in this paper.

  15. Exploring Heterogeneous NoC Design Space in Heterogeneous GPU-CPU Architectures

    Institute of Scientific and Technical Information of China (English)

    方娟; 姚治成; 冷镇宇; 隋秀峰; 刘思彤

    2015-01-01

    Computer architecture is transiting from the multicore era into the heterogeneous era in which heterogeneous architectures use on-chip networks to access shared resources and how a network is configured will likely have a significant impact on overall performance and power consumption. Recently, heterogeneous network on chip (NoC) has been proposed not only to achieve performance comparable to that of the NoCs with buffered routers but also to reduce buffer cost and energy consumption. However, heterogeneous NoC design for heterogeneous GPU-CPU architectures has not been studied in depth. This paper first evaluates the performance and power consumption of a variety of static hot-potato based heterogeneous NoCs with different buffered and bufferless router placements, which is helpful to explore the design space for heterogeneous GPU-CPU interconnection. Then it proposes Unidirectional Flow Control (UFC), a simple credit-based flow control mechanism for heterogeneous NoC in GPU-CPU architectures to control network congestion. UFC can guarantee that there are always unoccupied entries in buffered routers to receive flits coming from adjacent bufferless routers. Our evaluations show that when compared to hot-potato routing, UFC improves performance by an average of 14.1%with energy increased by an average of 5.3%only.

  16. Exploring simple assessment methods for lighting quality with architecture and design students

    DEFF Research Database (Denmark)

    Madsen, Merete

    2006-01-01

    Architecture and design students are frequently required to establish suitable lighting conditions for the buildings and spaces they design as part of their studio courses. While lighting design guidelines are avaiilable, students find out quickly, that lighting quality is a complex issue...... that cannot be assessed by simple equations or rules-of-thumb. Balancing the many an often contradictory aspects of energy efficiency and high quality lighting design is a complex undertaking not just for students. The work described in this paper is one result of an academic staff exchange between...... the Schools of Architecture in Copenhagen and Victoria University of Wellington (New Zealand). The authors explore two approaches to teaching students simple assessment methods that can contribute to making more informed decisions about the luminous environment and its quality. One approach deals...

  17. A Sustainable Architecture for Lunar Resource Prospecting from an EML-based Exploration Platform

    Science.gov (United States)

    Klaus, K.; Post, K.; Lawrence, S. J.

    2012-12-01

    Introduction - We present a point of departure architecture for prospecting for Lunar Resources from an Exploration Platform at the Earth - Moon Lagrange points. Included in our study are launch vehicle, cis-lunar transportation architecture, habitat requirements and utilization, lander/rover concepts and sample return. Different transfer design techniques can be explored by mission designers, testing various propulsive systems, maneuvers, rendezvous, and other in-space and surface operations. Understanding the availability of high and low energy trajectory transfer options opens up the possibility of exploring the human and logistics support mission design space and deriving solutions never before contemplated. For sample return missions from the lunar surface, low-energy transfers could be utilized between EML platform and the surface as well as return of samples to EML-based spacecraft. Human Habitation at the Exploration Platform - Telerobotic and telepresence capabilities are considered by the agency to be "grand challenges" for space technology. While human visits to the lunar surface provide optimal opportunities for field geologic exploration, on-orbit telerobotics may provide attractive early opportunities for geologic exploration, resource prospecting, and other precursor activities in advance of human exploration campaigns and ISRU processing. The Exploration Platform provides a perfect port for a small lander which could be refueled and used for multiple missions including sample return. The EVA and robotic capabilities of the EML Exploration Platform allow the lander to be serviced both internally and externally, based on operational requirements. The placement of the platform at an EML point allows the lander to access any site on the lunar surface, thus providing the global lunar surface access that is commonly understood to be required in order to enable a robust lunar exploration program. Designing the sample return lander for low

  18. Heterogeneous Sensor Data Exploration and Sustainable Declarative Monitoring Architecture: Application to Smart Building

    Science.gov (United States)

    Servigne, S.; Gripay, Y.; Pinarer, O.; Samuel, J.; Ozgovde, A.; Jay, J.

    2016-09-01

    Concerning energy consumption and monitoring architectures, our goal is to develop a sustainable declarative monitoring architecture for lower energy consumption taking into account the monitoring system itself. Our second is to develop theoretical and practical tools to model, explore and exploit heterogeneous data from various sources in order to understand a phenomenon like energy consumption of smart building vs inhabitants' social behaviours. We focus on a generic model for data acquisition campaigns based on the concept of generic sensor. The concept of generic sensor is centered on acquired data and on their inherent multi-dimensional structure, to support complex domain-specific or field-oriented analysis processes. We consider that a methodological breakthrough may pave the way to deep understanding of voluminous and heterogeneous scientific data sets. Our use case concerns energy efficiency of buildings to understand relationship between physical phenomena and user behaviors. The aim of this paper is to give a presentation of our methodology and results concerning architecture and user-centric tools.

  19. HETEROGENEOUS SENSOR DATA EXPLORATION AND SUSTAINABLE DECLARATIVE MONITORING ARCHITECTURE: APPLICATION TO SMART BUILDING

    Directory of Open Access Journals (Sweden)

    S. Servigne

    2016-09-01

    Full Text Available Concerning energy consumption and monitoring architectures, our goal is to develop a sustainable declarative monitoring architecture for lower energy consumption taking into account the monitoring system itself. Our second is to develop theoretical and practical tools to model, explore and exploit heterogeneous data from various sources in order to understand a phenomenon like energy consumption of smart building vs inhabitants' social behaviours. We focus on a generic model for data acquisition campaigns based on the concept of generic sensor. The concept of generic sensor is centered on acquired data and on their inherent multi-dimensional structure, to support complex domain-specific or field-oriented analysis processes. We consider that a methodological breakthrough may pave the way to deep understanding of voluminous and heterogeneous scientific data sets. Our use case concerns energy efficiency of buildings to understand relationship between physical phenomena and user behaviors. The aim of this paper is to give a presentation of our methodology and results concerning architecture and user-centric tools.

  20. Three-dimensional telomere architecture of esophageal squamous cell carcinoma: comparison of tumor and normal epithelial cells.

    Science.gov (United States)

    Sunpaweravong, S; Sunpaweravong, P; Sathitruangsak, C; Mai, S

    2016-05-01

    Telomeres are repetitive nucleotide sequences (TTAGGG)n located at the ends of chromosomes that function to preserve chromosomal integrity and prevent terminal end-to-end fusions. Telomere loss or dysfunction results in breakage-bridge-fusion cycles, aneuploidy, gene amplification and chromosomal rearrangements, which can lead to genomic instability and promote carcinogenesis. Evaluating the hypothesis that changes in telomeres contribute to the development of esophageal squamous cell carcinoma (ESCC) and to determine whether there are differences between young and old patients, we compared the three-dimensional (3D) nuclear telomere architecture in ESCC tumor cells with that of normal epithelial cells obtained from the same patient. Patients were equally divided by age into two groups, one comprising those less than 45 years of age and the other consisting of those over 80 years of age. Tumor and normal epithelial cells located at least 10 cm from the border of the tumor were biopsied in ESCC patients. Hematoxylin and eosin staining was performed for each sample to confirm and identify the cancer and normal epithelial cells. This study was based on quantitative 3D fluorescence in situ hybridization (Q-FISH), 3D imaging and 3D analysis of paraffin-embedded slides. The 3D telomere architecture data were computer analyzed using 100 nuclei per slide. The following were the main parameters compared: the number of signals (number of telomeres), signal intensity (telomere length), number of telomere aggregates, and nuclear volume. Tumor and normal epithelial samples from 16 patients were compared. The normal epithelial cells had more telomere signals and higher intensities than the tumor cells, with P-values of P architecture and found no statistically significant differences in any parameter tested between the young and old patients in either the tumor or epithelial cells. The 3D nuclear telomeric signature was able to detect differences in telomere architecture

  1. Requirements for Designing Life Support System Architectures for Crewed Exploration Missions Beyond Low-Earth Orbit

    Science.gov (United States)

    Howard, David; Perry,Jay; Sargusingh, Miriam; Toomarian, Nikzad

    2016-01-01

    NASA's technology development roadmaps provide guidance to focus technological development on areas that enable crewed exploration missions beyond low-Earth orbit. Specifically, the technology area roadmap on human health, life support and habitation systems describes the need for life support system (LSS) technologies that can improve reliability and in-situ maintainability within a minimally-sized package while enabling a high degree of mission autonomy. To address the needs outlined by the guiding technology area roadmap, NASA's Advanced Exploration Systems (AES) Program has commissioned the Life Support Systems (LSS) Project to lead technology development in the areas of water recovery and management, atmosphere revitalization, and environmental monitoring. A notional exploration LSS architecture derived from the International Space has been developed and serves as the developmental basis for these efforts. Functional requirements and key performance parameters that guide the exploration LSS technology development efforts are presented and discussed. Areas where LSS flight operations aboard the ISS afford lessons learned that are relevant to exploration missions are highlighted.

  2. Advanced Avionics and Processor Systems for a Flexible Space Exploration Architecture

    Science.gov (United States)

    Keys, Andrew S.; Adams, James H.; Smith, Leigh M.; Johnson, Michael A.; Cressler, John D.

    2010-01-01

    The Advanced Avionics and Processor Systems (AAPS) project, formerly known as the Radiation Hardened Electronics for Space Environments (RHESE) project, endeavors to develop advanced avionic and processor technologies anticipated to be used by NASA s currently evolving space exploration architectures. The AAPS project is a part of the Exploration Technology Development Program, which funds an entire suite of technologies that are aimed at enabling NASA s ability to explore beyond low earth orbit. NASA s Marshall Space Flight Center (MSFC) manages the AAPS project. AAPS uses a broad-scoped approach to developing avionic and processor systems. Investment areas include advanced electronic designs and technologies capable of providing environmental hardness, reconfigurable computing techniques, software tools for radiation effects assessment, and radiation environment modeling tools. Near-term emphasis within the multiple AAPS tasks focuses on developing prototype components using semiconductor processes and materials (such as Silicon-Germanium (SiGe)) to enhance a device s tolerance to radiation events and low temperature environments. As the SiGe technology will culminate in a delivered prototype this fiscal year, the project emphasis shifts its focus to developing low-power, high efficiency total processor hardening techniques. In addition to processor development, the project endeavors to demonstrate techniques applicable to reconfigurable computing and partially reconfigurable Field Programmable Gate Arrays (FPGAs). This capability enables avionic architectures the ability to develop FPGA-based, radiation tolerant processor boards that can serve in multiple physical locations throughout the spacecraft and perform multiple functions during the course of the mission. The individual tasks that comprise AAPS are diverse, yet united in the common endeavor to develop electronics capable of operating within the harsh environment of space. Specifically, the AAPS tasks for

  3. A Sustainable, Reliable Mission-Systems Architecture that Supports a System of Systems Approach to Space Exploration

    Science.gov (United States)

    Watson, Steve; Orr, Jim; O'Neil, Graham

    2004-01-01

    A mission-systems architecture based on a highly modular "systems of systems" infrastructure utilizing open-standards hardware and software interfaces as the enabling technology is absolutely essential for an affordable and sustainable space exploration program. This architecture requires (a) robust communication between heterogeneous systems, (b) high reliability, (c) minimal mission-to-mission reconfiguration, (d) affordable development, system integration, and verification of systems, and (e) minimum sustaining engineering. This paper proposes such an architecture. Lessons learned from the space shuttle program are applied to help define and refine the model.

  4. Architecture for the silver generation: exploring the meaning of appropriate space for ageing in a Swedish municipality.

    Science.gov (United States)

    Andersson, Jonas E

    2011-03-01

    This paper focuses on an architecture competition for the silver generation, namely those aged 65 years and older. Twenty-seven Swedish informants were interviewed using an interviewing guide that included a photographic survey. The informants emphasised aesthetic dimensions in architecture for the prolongation of ageing in place and independent living in a residential home. This study highlights the individual adjustment of space, and the integrated location in existing urban settings near nature. Based on the findings, a habitational model for exploring the appropriate space for ageing is formulated. It suggests that architecture through location and spatial features needs to generate positive associations with the users.

  5. Evolvable Mars Campaign Long Duration Habitation Strategies: Architectural Approaches to Enable Human Exploration Missions

    Science.gov (United States)

    Simon, Matthew A.; Toups, Larry; Howe, A. Scott; Wald, Samuel I.

    2015-01-01

    The Evolvable Mars Campaign (EMC) is the current NASA Mars mission planning effort which seeks to establish sustainable, realistic strategies to enable crewed Mars missions in the mid-2030s timeframe. The primary outcome of the Evolvable Mars Campaign is not to produce "The Plan" for sending humans to Mars, but instead its intent is to inform the Human Exploration and Operations Mission Directorate near-term key decisions and investment priorities to prepare for those types of missions. The FY'15 EMC effort focused upon analysis of integrated mission architectures to identify technically appealing transportation strategies, logistics build-up strategies, and vehicle designs for reaching and exploring Mars moons and Mars surface. As part of the development of this campaign, long duration habitats are required which are capable of supporting crew with limited resupply and crew abort during the Mars transit, Mars moons, and Mars surface segments of EMC missions. In particular, the EMC design team sought to design a single, affordable habitation system whose manufactured units could be outfitted uniquely for each of these missions and reused for multiple crewed missions. This habitat system must provide all of the functionality to safely support 4 crew for long durations while meeting mass and volume constraints for each of the mission segments set by the chosen transportation architecture and propulsion technologies. This paper describes several proposed long-duration habitation strategies to enable the Evolvable Mars Campaign through improvements in mass, cost, and reusability, and presents results of analysis to compare the options and identify promising solutions. The concepts investigated include several monolithic concepts: monolithic clean sheet designs, and concepts which leverage the co-manifested payload capability of NASA's Space Launch System (SLS) to deliver habitable elements within the Universal Payload Adaptor between the SLS upper stage and the Orion

  6. Tumorer

    DEFF Research Database (Denmark)

    Prause, J.U.; Heegaard, S.

    2005-01-01

    oftalmologi, øjenlågstumorer, conjunctivale tumorer, malignt melanom, retinoblastom, orbitale tumorer......oftalmologi, øjenlågstumorer, conjunctivale tumorer, malignt melanom, retinoblastom, orbitale tumorer...

  7. An Autonomy Architecture for Aerobot Exploration of the Saturnian Moon Titan

    Science.gov (United States)

    Elfes, Alberto; Hall, Jeffery L.; Kulczycki, Eric A.; Clouse, Daniel S.; Morfopoulos, Arin C.; Montgomery, James F.; Cameron, Jonathan M.; Ansar, Adnan; Machuzak, Richard J.

    2008-01-01

    The Huygens probe arrived at Saturn's moon Titan on January 14, 2005, unveiling a world that is radically different from any other in the Solar system. The data obtained, complemented by continuing observations from the Cassini spacecraft, show methane lakes, river channels and drainage basins, sand dunes, cryovolcanos and sierras. This has lead to an enormous scientific interest in a follow-up mission to Titan, using a robotic lighter-than-air vehicle (or aerobot). Aerobots have modest power requirements, can fly missions with extended durations, and have very long distance traverse capabilities. They can execute regional surveys, transport and deploy scientific instruments and in-situ laboratory facilities over vast distances, and also provide surface sampling at strategic science sites. This paper describes our progress in the development of the autonomy technologies that will be required for exploration of Titan. We provide an overview of the autonomy architecture and some of its key components. We also show results obtained from autonomous flight tests conducted in the Mojave desert.

  8. Functional Performance of an Enabling Atmosphere Revitalization Subsystem Architecture for Deep Space Exploration Missions

    Science.gov (United States)

    Perry, Jay L.; Abney, Morgan B.; Frederick, Kenneth R.; Greenwood, Zachary W.; Kayatin, Matthew J.; Newton, Robert L.; Parrish, Keith J.; Roman, Monsi C.; Takada, Kevin C.; Miller, Lee A.; Scott, Joseph P.; Stanley, Christine M.

    2013-01-01

    A subsystem architecture derived from the International Space Station's (ISS) Atmosphere Revitalization Subsystem (ARS) has been functionally demonstrated. This ISS-derived architecture features re-arranged unit operations for trace contaminant control and carbon dioxide removal functions, a methane purification component as a precursor to enhance resource recovery over ISS capability, operational modifications to a water electrolysis-based oxygen generation assembly, and an alternative major atmospheric constituent monitoring concept. Results from this functional demonstration are summarized and compared to the performance observed during ground-based testing conducted on an ISS-like subsystem architecture. Considerations for further subsystem architecture and process technology development are discussed.

  9. A method to evaluate utility for architectural comparisons for a campaign to explore the surface of Mars

    Science.gov (United States)

    Ward, Eric D.; Webb, Ryan R.; deWeck, Olivier L.

    2016-11-01

    There is a general consensus that Mars is the next high priority destination for human space exploration. There has been no lack of analysis and recommendations for human missions to Mars, including, for example, the NASA Design Reference Architectures and the Mars Direct proposal. These studies and others usually employ the traditional approach of selecting a baseline mission architecture and running individual trade studies. However, this can cause blind spots, as not all combinations are explored. An alternative approach is to holistically analyze the entire architectural trade-space such that all of the possible system interactions are identified and measured. In such a framework, an optimal design is sought by minimizing cost for maximal value. While cost is relatively easy to model for manned spaceflight, value is more difficult to define. In our efforts to develop a surface base architecture for the MIT Mars 2040 project, we explored several methods for quantifying value, including technology development benefits, challenge, and various metrics for measuring scientific return. We developed a science multi-score method that combines astrobiology and geologic research goals, which is weighted by the crew-member hours that can be used for scientific research rather than other activities.

  10. How toExplore Golden Ratio in Architecture and Designing City

    Directory of Open Access Journals (Sweden)

    Wezha Hawez Baiz

    2016-08-01

    Full Text Available In architecture, there are many different standards and rules to design buildings, urban and planning and principles and proportion are the clear limitations among the main standards. Golden ratio or golden section is considered as a clear proportion in the architecturaldesign. Severalacademic researches and studies can befound that talk about the golden ratio. This ratio also can be seen in natural division, arts, music and architecture. It is measured as a standard for the aesthetic and beauty of the architectural appearance. Thepresent paperdiscusses the golden ratio in general, its history that shows first use and understandingsand related to which ancient civilization. Furthermore, it explains the position of the golden ratio in architecture principles. Following that, this paper discoversa number of case studies that designed with this ratio existed around the world. Also, itdemonstratesthat,how it can be applicable in architecture field today? Then there isa summaryof the research inthe conclusion.

  11. Architectural Prototyping

    DEFF Research Database (Denmark)

    Bardram, Jakob; Christensen, Henrik Bærbak; Hansen, Klaus Marius

    2004-01-01

    A major part of software architecture design is learning how specific architectural designs balance the concerns of stakeholders. We explore the notion of "architectural prototypes", correspondingly architectural prototyping, as a means of using executable prototypes to investigate stakeholders......' concerns with respect to a system under development. An architectural prototype is primarily a learning and communication vehicle used to explore and experiment with alternative architectural styles, features, and patterns in order to balance different architectural qualities. The use of architectural...... prototypes in the development process is discussed, and we argue that such prototypes can play a role throughout the entire process. The use of architectural prototypes is illustrated by three distinct cases of creating software systems. We argue that architectural prototyping can provide key insights...

  12. Architectural prototyping

    DEFF Research Database (Denmark)

    Bardram, Jakob Eyvind; Christensen, Henrik Bærbak; Hansen, Klaus Marius

    2004-01-01

    A major part of software architecture design is learning how specific architectural designs balance the concerns of stakeholders. We explore the notion of "architectural prototypes", correspondingly architectural prototyping, as a means of using executable prototypes to investigate stakeholders......' concerns with respect to a system under development. An architectural prototype is primarily a learning and communication vehicle used to explore and experiment with alternative architectural styles, features, and patterns in order to balance different architectural qualities. The use of architectural...... prototypes in the development process is discussed, and we argue that such prototypes can play a role throughout the entire process. The use of architectural prototypes is illustrated by three distinct cases of creating software systems. We argue that architectural prototyping can provide key insights...

  13. Development of a Thermal Control Architecture for the Mars Exploration Rovers

    Science.gov (United States)

    Novak, Keith S.; Phillips, Charles J.; Birur, Gajanana C.; Sunada, Eric T.; Pauken, Michael T.

    2003-01-01

    In May and June of 2003, the National Aeronautics and Space Administration (NASA) will launch two roving science vehicles on their way to Mars. They will land on Mars in January and February of 2004 and carry out 90-Sol missions. This paper addresses the thermal design architecture of the Mars Exploration Rover (MER) developed for Mars surface operations. The surface atmosphere temperature on Mars can vary from 0°C in the heat of the day to -100°C in the early morning, prior to sunrise. Heater usage at night must be minimized in order to conserve battery energy. The desire to minimize nighttime heater energy led to a design in which all temperature sensitive electronics and the battery were placed inside a well-insulated (carbon-opacified aerogel lined) Warm Electronics Box (WEB). In addition, radioisotope heater units (RHU's, non-electric heat sources) were mounted on the battery and electronics inside the WEB. During the Martian day, the electronics inside the WEB dissipate a large amount of energy (over 710 W*hrs). This heat energy raises the internal temperatures inside the WEB. Hardware items that have similar temperature limits were conductively coupled together to share heat and concentrate thermal mass. Thermal mass helped to minimize temperature increases in the hot case (with maximum internal dissipation) and minimize temperature decreases in the cold case (with minimum internal dissipation). In order to prevent the battery from exceeding its maximum allowable flight temperature, wax-actuated passive thermal switches were placed between the battery and an external radiator. This paper discusses the design philosophies and system requirements that resulted in a successful Mars rover thermal design.

  14. Exploring multiple feature combination strategies with a recurrent neural network architecture for off-line handwriting recognition

    Science.gov (United States)

    Mioulet, L.; Bideault, G.; Chatelain, C.; Paquet, T.; Brunessaux, S.

    2015-01-01

    The BLSTM-CTC is a novel recurrent neural network architecture that has outperformed previous state of the art algorithms in tasks such as speech recognition or handwriting recognition. It has the ability to process long term dependencies in temporal signals in order to label unsegmented data. This paper describes different ways of combining features using a BLSTM-CTC architecture. Not only do we explore the low level combination (feature space combination) but we also explore high level combination (decoding combination) and mid-level (internal system representation combination). The results are compared on the RIMES word database. Our results show that the low level combination works best, thanks to the powerful data modeling of the LSTM neurons.

  15. Exploring the Applications of Bio-Eco Architecture for Sustainable Design and Construction process

    Directory of Open Access Journals (Sweden)

    M. M. Naguib

    2013-04-01

    Full Text Available It has been commonly noted that the main perception of nature influenced forms isbasically aesthetic while little concern is given to the importance of inspiring from naturein the construction and structural performance of buildings as well as in the naturalecological architectural solutions, thus, this paper will focus on bio-inspired architectureapproach which embraces the eco-friendly practices of sustainable construction, the useof natural materials and the energy conservation by mimicking the natural life.A number of bio-inspired architectural designs will be illustrated presenting acomprehensive analysis of bio-inspired role to be played in developing the concept ofecological sustainable design and construction in contemporary architecture.Building must teach the society with new ecological moral, thus, a better understanding ofbiological morphogenesis can usefully inspire architectural design to resolve challengesthat have already been resolved by nature that will not only help in creating a healthyenvironment but will also produce positive environmental impacts.Bio-Eco Architecture harnesses and replicates the principles found in nature in order tocreate built environment which benefit people and other living creatures as well as safe-guarding the biodiversity; thus, Biomimetics in architecture will help develop a culture ofactive environmental design.

  16. Changes in root architecture under elevated concentrations of CO₂ and nitrogen reflect alternate soil exploration strategies.

    Science.gov (United States)

    Beidler, Katilyn V; Taylor, Benton N; Strand, Allan E; Cooper, Emily R; Schönholz, Marcos; Pritchard, Seth G

    2015-02-01

    Predicting the response of fine roots to increased atmospheric CO₂ concentration has important implications for carbon (C) and nutrient cycling in forest ecosystems. Root architecture is known to play an important role in how trees acquire soil resources in changing environments. However, the effects of elevated CO₂ on the fine-root architecture of trees remain unclear. We investigated the architectural response of fine roots exposed to 14 yr of CO₂ enrichment and 6 yr of nitrogen (N) fertilization in a Pinus taeda (loblolly pine) forest. Root traits reflecting geometry, topology and uptake function were measured on intact fine-root branches removed from soil monoliths and the litter layer. CO₂ enrichment resulted in the development of a fine-root pool that was less dichotomous and more exploratory under N-limited conditions. The per cent mycorrhizal colonization did not differ among treatments, suggesting that root growth and acclimation to elevated CO₂ were quantitatively more important than increased mycorrhizal associations. Our findings emphasize the importance of architectural plasticity in response to environmental change and suggest that changes in root architecture may allow trees to effectively exploit larger volumes of soil, thereby pre-empting progressive nutrient limitations.

  17. Exploration of paclitaxel (Taxol) as a treatment for malignant tumors in cats: a descriptive case series.

    Science.gov (United States)

    Kim, Jennifer; Doerr, Mary; Kitchell, Barbara E

    2015-02-01

    Paclitaxel, an effective chemotherapeutic agent in human oncology, has received little evaluation in feline patients. The diluent used to solubilize paclitaxel, polyoxyethylated castor oil (Cremophor EL), causes anaphylactoid reactions in human and dogs, which limits enthusiasm for use of this agent in veterinary oncology. Nine feline patients with measurable malignant tumors were treated with paclitaxel at a dosage of 80 mg/m(2) intravenously every 21 days for up to two doses. Adverse effects, including evidence of toxicity and anaphylactoid reactions, were assessed. Tumor response, progression and patient time to progression (TTP) were also recorded. Adverse effects included grade III and IV thrombocytopenia, grade III gastrointestinal signs (vomiting and constipation) and hypersensitivity reactions, seen in a total of five patients. Anaphylactoid reactions resolved with appropriate management. Stable disease and partial response were observed in 56% of feline patients. Median TTP was 28 days (range 15-45 days). Intravenous paclitaxel is a safe treatment option for feline malignant tumor patients. Future investigation is warranted to explore the effectiveness and appropriate application of this agent for specific tumor types.

  18. Tumor vascular architecture and function evaluated by non-invasive susceptibility MRI methods and immunohistochemistry.

    NARCIS (Netherlands)

    Robinson, S.P.; Rijken, P.F.J.W.; Howe, F.A.; McSheehy, P.M.; Sanden, B.P.J. van den; Heerschap, A.; Stubbs, M.; Kogel, A.J. van der; Griffiths, J.R.

    2003-01-01

    PURPOSE: To investigate the physiological origins responsible for the varying blood oxygenation level dependent (BOLD) magnetic resonance imaging (MRI) responses to carbogen (95% O(2)/5% CO(2)) breathing observed with different tumor types. MATERIALS AND METHODS: Susceptibility contrast-enhanced MRI

  19. Exploring business model innovation in professional service firms: Insights from architecture

    NARCIS (Netherlands)

    Lieftink, B.; Bos-de Vos, M.; Lauche, K.; Smits, A.

    2014-01-01

    Business model innovation may be a significant source of competitive advantage and firm performance. New ways of doing business have become increasingly important in the professional service sector. This research specifically focuses on business model innovation by architecture firms, which are suff

  20. Exploring architectural history through the Petroleumscapes of the Randstad to imagine new fossil-free futures

    NARCIS (Netherlands)

    Hein, C.M.

    2015-01-01

    Architectural history in the 21st century is expanding beyond its traditional focus on specific styles, materials, or building typologies and on famous architects, iconic movements, or paradigmatic cities. Following other historical fields that have embraced more complex approaches and adopted new a

  1. Architecture-Level Exploration of Alternative Interconnection Schemes Targeting 3D FPGAs: A Software-Supported Methodology

    Directory of Open Access Journals (Sweden)

    Kostas Siozios

    2008-01-01

    Full Text Available In current reconfigurable architectures, the interconnection structures increasingly contribute more to the delay and power consumption. The demand for increased clock frequencies and logic density (smaller area footprint makes the problem even more important. Three-dimensional (3D architectures are able to alleviate this problem by accommodating a number of functional layers, each of which might be fabricated in different technology. However, the benefits of such integration technology have not been sufficiently explored yet. In this paper, we propose a software-supported methodology for exploring and evaluating alternative interconnection schemes for 3D FPGAs. In order to support the proposed methodology, three new CAD tools were developed (part of the 3D MEANDER Design Framework. During our exploration, we study the impact of vertical interconnection between functional layers in a number of design parameters. More specifically, the average gains in operation frequency, power consumption, and wirelength are 35%, 32%, and 13%, respectively, compared to existing 2D FPGAs with identical logic resources. Also, we achieve higher utilization ratio for the vertical interconnections compared to existing approaches by 8% for designing 3D FPGAs, leading to cheaper and more reliable devices.

  2. Exploration and Evaluation of Nanometer Low-power Multi-core VLSI Computer Architectures

    Science.gov (United States)

    2015-03-01

    reliable system that can be utilized for producing state-of-the- art computer architectures, especially for silicon implementations. The research...stitch elements together via placing each layout and routing wire between known pins. Early layout editors, such as the Magic Layout Editor, had...within the University of Berkeley mainly for a public domain VLSI tool called Magic [15]. The Tcl language is useful in that it has an easy-to- learn

  3. Exploring the Applications of Bio-Eco Architecture for Sustainable Design and Construction process

    OpenAIRE

    M. M. Naguib,M; A. M Hanafi

    2013-01-01

    It has been commonly noted that the main perception of nature influenced forms isbasically aesthetic while little concern is given to the importance of inspiring from naturein the construction and structural performance of buildings as well as in the naturalecological architectural solutions, thus, this paper will focus on bio-inspired architectureapproach which embraces the eco-friendly practices of sustainable construction, the useof natural materials and the energy conservation by mimickin...

  4. The Jupyter/IPython architecture: a unified view of computational research, from interactive exploration to communication and publication.

    Science.gov (United States)

    Ragan-Kelley, M.; Perez, F.; Granger, B.; Kluyver, T.; Ivanov, P.; Frederic, J.; Bussonnier, M.

    2014-12-01

    IPython has provided terminal-based tools for interactive computing in Python since 2001. The notebook document format and multi-process architecture introduced in 2011 have expanded the applicable scope of IPython into teaching, presenting, and sharing computational work, in addition to interactive exploration. The new architecture also allows users to work in any language, with implementations in Python, R, Julia, Haskell, and several other languages. The language agnostic parts of IPython have been renamed to Jupyter, to better capture the notion that a cross-language design can encapsulate commonalities present in computational research regardless of the programming language being used. This architecture offers components like the web-based Notebook interface, that supports rich documents that combine code and computational results with text narratives, mathematics, images, video and any media that a modern browser can display. This interface can be used not only in research, but also for publication and education, as notebooks can be converted to a variety of output formats, including HTML and PDF. Recent developments in the Jupyter project include a multi-user environment for hosting notebooks for a class or research group, a live collaboration notebook via Google Docs, and better support for languages other than Python.

  5. Guiding Requirements for Designing Life Support System Architectures for Crewed Exploration Missions Beyond Low-Earth Orbit

    Science.gov (United States)

    Perry, Jay L.; Sargusingh, Miriam J.; Toomarian, Nikzad

    2016-01-01

    The National Aeronautics and Space Administration's (NASA) technology development roadmaps provide guidance to focus technological development in areas that enable crewed exploration missions beyond low-Earth orbit. Specifically, the technology area roadmap on human health, life support and habitation systems describes the need for life support system (LSS) technologies that can improve reliability and in-flight maintainability within a minimally-sized package while enabling a high degree of mission autonomy. To address the needs outlined by the guiding technology area roadmap, NASA's Advanced Exploration Systems (AES) Program has commissioned the Life Support Systems (LSS) Project to lead technology development in the areas of water recovery and management, atmosphere revitalization, and environmental monitoring. A notional exploration LSS architecture derived from the International Space has been developed and serves as the developmental basis for these efforts. Functional requirements and key performance parameters that guide the exploration LSS technology development efforts are presented and discussed. Areas where LSS flight operations aboard the ISS afford lessons learned that are relevant to exploration missions are highlighted.

  6. Trade-Off Exploration for Target Tracking Application in a Customized Multiprocessor Architecture

    Directory of Open Access Journals (Sweden)

    Yassin El-Hillali

    2009-01-01

    Full Text Available This paper presents the design of an FPGA-based multiprocessor-system-on-chip (MPSoC architecture optimized for Multiple Target Tracking (MTT in automotive applications. An MTT system uses an automotive radar to track the speed and relative position of all the vehicles (targets within its field of view. As the number of targets increases, the computational needs of the MTT system also increase making it difficult for a single processor to handle it alone. Our implementation distributes the computational load among multiple soft processor cores optimized for executing specific computational tasks. The paper explains how we designed and profiled the MTT application to partition it among different processors. It also explains how we applied different optimizations to customize the individual processor cores to their assigned tasks and to assess their impact on performance and FPGA resource utilization. The result is a complete MTT application running on an optimized MPSoC architecture that fits in a contemporary medium-sized FPGA and that meets the application's real-time constraints.

  7. Trade-Off Exploration for Target Tracking Application in a Customized Multiprocessor Architecture

    Directory of Open Access Journals (Sweden)

    Saghir MazenAR

    2009-01-01

    Full Text Available Abstract This paper presents the design of an FPGA-based multiprocessor-system-on-chip (MPSoC architecture optimized for Multiple Target Tracking (MTT in automotive applications. An MTT system uses an automotive radar to track the speed and relative position of all the vehicles (targets within its field of view. As the number of targets increases, the computational needs of the MTT system also increase making it difficult for a single processor to handle it alone. Our implementation distributes the computational load among multiple soft processor cores optimized for executing specific computational tasks. The paper explains how we designed and profiled the MTT application to partition it among different processors. It also explains how we applied different optimizations to customize the individual processor cores to their assigned tasks and to assess their impact on performance and FPGA resource utilization. The result is a complete MTT application running on an optimized MPSoC architecture that fits in a contemporary medium-sized FPGA and that meets the application's real-time constraints.

  8. Roles of brca2 (fancd1 in oocyte nuclear architecture, gametogenesis, gonad tumors, and genome stability in zebrafish.

    Directory of Open Access Journals (Sweden)

    Adriana Rodríguez-Marí

    2011-03-01

    Full Text Available Mild mutations in BRCA2 (FANCD1 cause Fanconi anemia (FA when homozygous, while severe mutations cause common cancers including breast, ovarian, and prostate cancers when heterozygous. Here we report a zebrafish brca2 insertional mutant that shares phenotypes with human patients and identifies a novel brca2 function in oogenesis. Experiments showed that mutant embryos and mutant cells in culture experienced genome instability, as do cells in FA patients. In wild-type zebrafish, meiotic cells expressed brca2; and, unexpectedly, transcripts in oocytes localized asymmetrically to the animal pole. In juvenile brca2 mutants, oocytes failed to progress through meiosis, leading to female-to-male sex reversal. Adult mutants became sterile males due to the meiotic arrest of spermatocytes, which then died by apoptosis, followed by neoplastic proliferation of gonad somatic cells that was similar to neoplasia observed in ageing dead end (dnd-knockdown males, which lack germ cells. The construction of animals doubly mutant for brca2 and the apoptotic gene tp53 (p53 rescued brca2-dependent sex reversal. Double mutants developed oocytes and became sterile females that produced only aberrant embryos and showed elevated risk for invasive ovarian tumors. Oocytes in double-mutant females showed normal localization of brca2 and pou5f1 transcripts to the animal pole and vasa transcripts to the vegetal pole, but had a polarized rather than symmetrical nucleus with the distribution of nucleoli and chromosomes to opposite nuclear poles; this result revealed a novel role for Brca2 in establishing or maintaining oocyte nuclear architecture. Mutating tp53 did not rescue the infertility phenotype in brca2 mutant males, suggesting that brca2 plays an essential role in zebrafish spermatogenesis. Overall, this work verified zebrafish as a model for the role of Brca2 in human disease and uncovered a novel function of Brca2 in vertebrate oocyte nuclear architecture.

  9. Trade space evaluation of multi-mission architectures for the exploration of Europa

    Science.gov (United States)

    Alibay, F.; Strange, N. J.

    Recent cuts to NASA's planetary exploration budget have precipitated a debate in the community on whether large flagship missions to planetary bodies in the outer solar system or sequences of smaller missions as part of a long-term exploration program would be more beneficial. The work presented explores the trade between these two approaches as applied to the exploration of Europa and concentrates on identifying combinations of flyby, orbiter and/or lander missions that achieve high value at a lower cost than the Jupiter Europa Orbiter (JEO) flagship mission concept. The effects of the value attributed to the four main science objectives for Europa, which can be broadly classified as investigating the ocean, ice-shell, composition and geology, are demonstrated. The current approach proposed to complete the ocean exploration objective is shown to have conflicting requirements with the other three objectives. For missions that fully address all the science objectives, such as JEO, the ocean goal is therefore found to be the main cost driver. Instrument combinations for low-cost flyby missions are also presented, and simple lander designs able to achieve a wide range of objectives at a low additional cost are identified. Finally, the current designs for the Europa Habitability Mission (EHM) are compared to others in the trade space, based on the prioritization given to the science goals for the exploration of Europa. The current EHM flyby mission (Clipper) is found to be highly promising in terms of providing very high potential science value at a low cost.

  10. Exploration of the Adaptive Neuro - Fuzzy Inference System Architecture and its Applications

    Directory of Open Access Journals (Sweden)

    Okereke Eze Aru

    2016-09-01

    Full Text Available In this paper we exhibited an architecture and essential learning process basic in fuzzy inference system and adaptive neuro fuzzy inference system which is a hybrid network implemented in framework of adaptive network. In genuine figuring environment, soft computing techniques including neural network, fuzzy logic algorithms have been generally used to infer a real choice utilizing given input or output information traits, ANFIS can build mapping taking into account both human learning and hybrid algorithms. This study includes investigation of ANFIS methodology. ANFIS procedure is utilized to display nonlinear functions, to control a standout amongst the most essential parameters of the impelling machine and anticipate a turbulent time arrangement, all yielding more viable, quicker result.

  11. Hierarchical video surveillance architecture: a chassis for video big data analytics and exploration

    Science.gov (United States)

    Ajiboye, Sola O.; Birch, Philip; Chatwin, Christopher; Young, Rupert

    2015-03-01

    There is increasing reliance on video surveillance systems for systematic derivation, analysis and interpretation of the data needed for predicting, planning, evaluating and implementing public safety. This is evident from the massive number of surveillance cameras deployed across public locations. For example, in July 2013, the British Security Industry Association (BSIA) reported that over 4 million CCTV cameras had been installed in Britain alone. The BSIA also reveal that only 1.5% of these are state owned. In this paper, we propose a framework that allows access to data from privately owned cameras, with the aim of increasing the efficiency and accuracy of public safety planning, security activities, and decision support systems that are based on video integrated surveillance systems. The accuracy of results obtained from government-owned public safety infrastructure would improve greatly if privately owned surveillance systems `expose' relevant video-generated metadata events, such as triggered alerts and also permit query of a metadata repository. Subsequently, a police officer, for example, with an appropriate level of system permission can query unified video systems across a large geographical area such as a city or a country to predict the location of an interesting entity, such as a pedestrian or a vehicle. This becomes possible with our proposed novel hierarchical architecture, the Fused Video Surveillance Architecture (FVSA). At the high level, FVSA comprises of a hardware framework that is supported by a multi-layer abstraction software interface. It presents video surveillance systems as an adapted computational grid of intelligent services, which is integration-enabled to communicate with other compatible systems in the Internet of Things (IoT).

  12. An Energy and Performance Exploration of Network-on-Chip Architectures

    NARCIS (Netherlands)

    Banerjee, Arnab; Wolkotte, Pascal T.; Mullins, Robert D.; Moore, Simon W.; Smit, Gerard J.M.; Jha, N.K.

    2009-01-01

    In this paper, we explore the designs of a circuit-switched router, a wormhole router, a quality-of-service (QoS) supporting virtual channel router and a speculative virtual channel router and accurately evaluate the energy-performance tradeoffs they offer. Power results from the designs placed and

  13. An efficient FPGA implementation of MRI image filtering and tumor characterization using Xilinx system generator

    CERN Document Server

    Christe, S Allin; Kandaswamy, A

    2012-01-01

    This paper presents an efficient architecture for various image filtering algorithms and tumor characterization using Xilinx System Generator (XSG). This architecture offers an alternative through a graphical user interface that combines MATLAB, Simulink and XSG and explores important aspects concerned to hardware implementation. Performance of this architecture implemented in SPARTAN-3E Starter kit (XC3S500E-FG320) exceeds those of similar or greater resources architectures. The proposed architecture reduces the resources available on target device by 50%.

  14. Phenotypic and genotypic data integration and exploration through a web-service architecture

    Science.gov (United States)

    Nuzzo, Angelo; Riva, Alberto; Bellazzi, Riccardo

    2009-01-01

    Background Linking genotypic and phenotypic information is one of the greatest challenges of current genetics research. The definition of an Information Technology infrastructure to support this kind of studies, and in particular studies aimed at the analysis of complex traits, which require the definition of multifaceted phenotypes and the integration genotypic information to discover the most prevalent diseases, is a paradigmatic goal of Biomedical Informatics. This paper describes the use of Information Technology methods and tools to develop a system for the management, inspection and integration of phenotypic and genotypic data. Results We present the design and architecture of the Phenotype Miner, a software system able to flexibly manage phenotypic information, and its extended functionalities to retrieve genotype information from external repositories and to relate it to phenotypic data. For this purpose we developed a module to allow customized data upload by the user and a SOAP-based communications layer to retrieve data from existing biomedical knowledge management tools. In this paper we also demonstrate the system functionality by an example application of the system in which we analyze two related genomic datasets. Conclusion In this paper we show how a comprehensive, integrated and automated workbench for genotype and phenotype integration can facilitate and improve the hypothesis generation process underlying modern genetic studies. PMID:19828081

  15. Exploring Diverse Data Sets and Developing New Theories and Ideas With Project Integration Architecture

    Science.gov (United States)

    Benyo, Theresa L.; Jones, William H.

    2005-01-01

    The development of new ideas is the essence of scientific research. This is frequently done by developing models of physical processes and comparing model predictions with results from experiments. With models becoming ever more complex and data acquisition systems becoming more powerful, the researcher is burdened with wading through data ranging in volume up to a level of many terabytes and beyond. These data often come from multiple, heterogeneous sources and usually the methods for searching through it are at or near the manual level. In addition, current documentation methods are generally limited to researchers pen-and-paper style notebooks. Researchers may want to form constraint-based queries on a body of existing knowledge that is, itself, distributed over many different machines and environments and from the results of such queries then spawn additional queries, simulations, and data analyses in order to discover new insights into the problem being investigated. Currently, researchers are restricted to working within the boundaries of tools that are inefficient at probing current and legacy data to extend the knowledge of the problem at hand and reveal innovative and efficient solutions. A framework called the Project Integration Architecture is discussed that can address these desired functionalities.

  16. Project Ares: A Systems Engineering and Operations Architecture for the Exploration of Mars

    Science.gov (United States)

    1992-03-20

    spherical reception pattern (8:3-47). This pattern will be important in the event the satellite begins to tumble and ground controllers are attempting...via these antennas, while limited telemetry and data will be transmitted via the Ka-band antennia as mentioned above. If the mapper begins tumbling ...Aeronautics and Astronautics, 24-26 June 1991. 32. Dryer , Murray. "Solar Wind Disturbances Caused by Planets and Solar Flares." Exploration of the Outer Solar

  17. Exploring performance and energy tradeoffs for irregular applications: A case study on the Tilera many-core architecture

    Energy Technology Data Exchange (ETDEWEB)

    Panyala, Ajay; Chavarría-Miranda, Daniel; Manzano, Joseph B.; Tumeo, Antonino; Halappanavar, Mahantesh

    2017-06-01

    High performance, parallel applications with irregular data accesses are becoming a critical workload class for modern systems. In particular, the execution of such workloads on emerging many-core systems is expected to be a significant component of applications in data mining, machine learning, scientific computing and graph analytics. However, power and energy constraints limit the capabilities of individual cores, memory hierarchy and on-chip interconnect of such systems, thus leading to architectural and software trade-os that must be understood in the context of the intended application’s behavior. Irregular applications are notoriously hard to optimize given their data-dependent access patterns, lack of structured locality and complex data structures and code patterns. We have ported two irregular applications, graph community detection using the Louvain method (Grappolo) and high-performance conjugate gradient (HPCCG), to the Tilera many-core system and have conducted a detailed study of platform-independent and platform-specific optimizations that improve their performance as well as reduce their overall energy consumption. To conduct this study, we employ an auto-tuning based approach that explores the optimization design space along three dimensions - memory layout schemes, GCC compiler flag choices and OpenMP loop scheduling options. We leverage MIT’s OpenTuner auto-tuning framework to explore and recommend energy optimal choices for different combinations of parameters. We then conduct an in-depth architectural characterization to understand the memory behavior of the selected workloads. Finally, we perform a correlation study to demonstrate the interplay between the hardware behavior and application characteristics. Using auto-tuning, we demonstrate whole-node energy savings and performance improvements of up to 49:6% and 60% relative to a baseline instantiation, and up to 31% and 45:4% relative to manually optimized variants.

  18. Exploring architecture of xyloglucan cellulose nanocrystal complexes through enzyme susceptibility at different adsorption regimes.

    Science.gov (United States)

    Dammak, Abir; Quémener, Bernard; Bonnin, Estelle; Alvarado, Camille; Bouchet, Brigitte; Villares, Ana; Moreau, Céline; Cathala, Bernard

    2015-02-09

    Xyloglucan (XG) is believed to act as a cementing material that contributes to the cross-linking and mechanical properties of the cellulose framework in plant cell walls. XG can adsorb to the cellulose nanocrystal (CNC) surface in vitro in order to simulate this in vivo relationship. The target of our work was to investigate the sorption behavior of tamarind seed XG on CNC extracted from cotton linters at different XG/CNC concentration ratios, that is, different adsorption regimes regarding the XG-CNC complex organization and the enzymatic susceptibility of XG. First, we determined the adsorption isotherm. Second, XG-CNC complexes were enzymatically hydrolyzed using a xyloglucan-specific endoglucanase in order to quantify the different XG fractions involved in binding to CNC and to determine adsorption regimes, that is, presence of loops, tails, and trains. Finally, the architecture of the XG-CNC complex was investigated by transmission electron microscopy imaging of negatively stained XG-CNC suspensions and XG immunolabeled suspensions at different XG/CNC concentration ratios, both before and after xyloglucanase hydrolysis process. This study revealed that an increasing XG/CNC concentration ratio led to a change in the XG binding organization to CNC. At low XG/CNC concentration ratios, almost all XG chains were bound as trains to the CNC surface. In contrast, at increasing XG/CNC concentration ratios, the proportion of loops and tails increases. The organization change induces CNC aggregation to form a cellulose/XG network at low XG/CNC regimes, whereas CNC remains in the form of individual particles at higher XG/CNC regimes. Results are discussed both regarding the biological role of XG in plant cell walls and in the perspective of designing new biobased materials.

  19. 3D visualization tools to explore ancient architectures in South America

    Directory of Open Access Journals (Sweden)

    Roberto Pierdicca

    2016-11-01

    Full Text Available Chan Chan is a wide archaeological site located in Peru. Its knowledge is limited to the visit of Palacio Tschudi, the only restored up to now, whilst the majority of the site remains unknown to the visitors. The reasons are manifold. The site is very large and difficult to visit. Some well-conserved architectures, such as Huaca Arco Iris, are very far from the core centre. Furthermore, there are heavy factors of decay, mainly caused by illegal excavations, by marine salt and by the devastating phenomenon of El Niño. For these reasons, the majority of the decorative elements are protected by new mud brick walls. Finally, the vastness of the buildings makes difficult to understand their real value, even through a direct visit of the site. In order to overcome the aforesaid problems, we designed, developed and realized the museum exhibition presented in this paper. We named Esquina Multimedia an installation where every corner is aimed to solve a specific problem, providing the tourists with interactive and enjoyable applications.  The virtual tour allows reaching also the unreachable areas. An Augmented Reality (AR application has been developed in order to show ancient artefacts covered by the earth.  A web-browser has been specifically designed to show bas-reliefs, with HD visualization, anaglyph stereoscopic view and a 3D virtual model of both the structures and the bas-reliefs. At the same time, a wall-mounted panel representing a metric 3D reconstruction of the building helps the user to find the artefact position.  Descriptions of the hardware components and of the software details are presented, with particular focus regarding the implementation of the application, arguing how the digital approach could represent the only answer towards a full exploitation of archaeological sites. The paper also deals with the implementation of a web tool, specifically designed to display and browse 3D-Models.

  20. Hyper-interspersed NANO/MEMS - Architecture design for new concepts in miniature robotics for space exploration

    Science.gov (United States)

    Santoli, Salvatore

    1999-05-01

    Launch weight and volume requirements are substantially decreased by reduction of probe size in exploration mission systems, as mass and volume both scale as the third power of system size. Accordingly, the already quite developed MEMS (Micro Electro Mechanical System) technology, that offers low cost, small, light weight, and increasingly reliable devices through durability and redundancy, is strongly attractive as a near-term technology for significantly reducing the cost to launch and operate space systems. It is shown that the final goal of MEMS technology, i.e. the merging through solid state microdcvices of the functions of sensing, computation, communication and actuation, can lead to a new, biomimetic kind of miniature robotics, particularly suitable for planetary exploration, through molecular mono- electronics/MEMS integration jointly with a hyper-interspersed architecture made up of autonomous units embodying sensors, information processors and actuators. The problem tackled here concerns the basic design of such miniature robots, from some μm to insect size, featuring finely structured intelligent autonomous parts as smart skins, sensory and manipulating members working on the analogue external reality and communicating with their inner molecular level nondiscrete pseudo-analogue information processing networks. The (mesoscopic network)/MEMS units are shown to embody a quantum mechanical/macroscopic world connection, in which the nondiscrete molecular devices allow the automaton parts to perform very complex, fast information processing operations as metaphores of bionic functions like learning, attention, and decision making under uncertain conditions, this last due to the stochasticity inherent in the quantum network. Flexible architectures instead of von Neumann type rigid architectures in addition to hyper-interspersion of autonomous units can be realized through such nano/MEMS devices, and the μm — cm size of the whole robots and their organs

  1. Tumor

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008479 Preliminary study of MR elastography in brain tumors. XU Lei(徐磊), et al.Neurosci Imaging Center, Beijing Tiantan Hosp, Capital Med Univ, Beijing 100050.Chin J Radiol 2008;42(6):605-608. Objective To investigate the potential values of magnetic resonance elastography (MRE) for evaluating the brain tumor consistency in vivo. Methods Fourteen patients with known solid brain tumor (5 male, 9 female; age range: 16-63 years)

  2. Galaxy Evolution Spectroscopic Explorer (GESE): Science Rationale, Optical Design, and Telescope Architecture

    Science.gov (United States)

    Heap, Sara R.; Gong, Qian; Hull, Tony; Purves, Lloyd

    2014-01-01

    One of the key goals of NASA’s astrophysics program is to answer the question: How did galaxies evolve into the spiral, elliptical, and irregular galaxies that we see today? We describe a space mission concept called Galaxy Evolution Spectroscopic Explorer (GESE) to help address this question by making a large ultraviolet spectroscopic survey of galaxies at a redshift, z approximately 1 (look-back time of approximately 8 billion years). GESE is a 1.5-m space telescope with an near-ultraviolet (NUV) multi-object slit spectrograph covering the spectral range, 0.2-0.4 micrometers (0.1-0.2 micrometers as emitted by galaxies at a redshift, z approximately 1) at a spectral resolution of delta lambda=6 A.

  3. Inter-organizational design: exploring the relationship between formal architecture and ICT investments

    Science.gov (United States)

    Iubatti, Daniela; Masciarelli, Francesca; Simboli, Alberto

    This chapter aims to explore how the information-processing capabilities that emerge from a network structure affect the diffusion of innovation in a multidivisional organization. In particular, this study analyzes the role of firm investments in ICT to facilitate communication and knowledge diffusion. Using a qualitative approach, we investigate the behavior of an Italian multinational firm, Engineering S.p.A., analyzing our data using a content analysis procedure. Our results show the limited role of ICT in favoring knowledge exchange both inside and outside the firm's divisions: traditional communication patterns are generally preferred over the use of technologies for information sharing. Additionally, we find that key individuals who play a central role in the firm's communication network are unable to use ICTs for knowledge transfer. We conclude that this is the result of a strategic decision to keep top management practically unchanged since the firm was established. Therefore, key individuals act as filters to knowledge flows. Knowledge, in particular tacit knowledge, is transferred from key individuals to other actors through face-to-face contacts, thereby creating a diseconomy for the organization.

  4. Conceptual Design and Architecture of Mars Exploration Rover (MER) for Seismic Experiments Over Martian Surfaces

    Science.gov (United States)

    Garg, Akshay; Singh, Amit

    2012-07-01

    Keywords: MER, Mars, Rover, Seismometer Mars has been a subject of human interest for exploration missions for quite some time now. Both rover as well as orbiter missions have been employed to suit mission objectives. Rovers have been preferentially deployed for close range reconnaissance and detailed experimentation with highest accuracy. However, it is essential to strike a balance between the chosen science objectives and the rover operations as a whole. The objective of this proposed mechanism is to design a vehicle (MER) to carry out seismic studies over Martian surface. The conceptual design consists of three units i.e. Mother Rover as a Surrogate (Carrier) and Baby Rovers (two) as seeders for several MEMS-based accelerometer / seismometer units (Nodes). Mother Rover can carry these Baby Rovers, having individual power supply with solar cells and with individual data transmission capabilities, to suitable sites such as Chasma associated with Valles Marineris, Craters or Sand Dunes. Mother rover deploys these rovers in two opposite direction and these rovers follow a triangulation pattern to study shock waves generated through firing tungsten carbide shells into the ground. Till the time of active experiments Mother Rover would act as a guiding unit to control spatial spread of detection instruments. After active shock experimentation, the babies can still act as passive seismometer units to study and record passive shocks from thermal quakes, impact cratering & landslides. Further other experiments / payloads (XPS / GAP / APXS) can also be carried by Mother Rover. Secondary power system consisting of batteries can also be utilized for carrying out further experiments over shallow valley surfaces. The whole arrangement is conceptually expected to increase the accuracy of measurements (through concurrent readings) and prolong life cycle of overall experimentation. The proposed rover can be customised according to the associated scientific objectives and further

  5. Exploring Venus with high-altitude balloons: Science objectives and mission architectures

    Science.gov (United States)

    Baines, Kevin; Limaye, Sanjay; Zahnle, Kevin; Atreya, Sushil K.

    Following the trailblazing flights of the 1985 twin Soviet VEGA balloons, missions to fly in the high atmosphere of Venus near 55 km altitude have been proposed to both NASA's Discovery Program and ESA's Cosmic Vision. Such missions would address a variety of fundamental science issues highlighted in a variety of high-level NASA-authorized science documents in recent years, including the Decadal Study, various NASA roadmaps, and recommendations coming out of the Venus Exploration Analysis Group (VEXAG). Such missions would in particular address key questions of Venus's origin, evolution, and current state, including detailed measurements of (1) trace gases associated with Venus's active photoand thermo-chemistry and (2) measurements of vertical motions and local temperature which characterize convective and wave processes. As an example of what can be done with a small mission (less than 500M US dollars), the Venus Aerostatic-Lift Observatories for in-situ Research (VALOR) Discovery mission will be discussed. This mission would fly twin balloon-borne aerostats over temperate and polar latitudes, sampling rare gases, chemicals and dynamics in two distinct latitude regions for several days. A variety of scenarios for the origin, formation, and evolution of Venus would be tested by sampling all the noble gases and their isotopes, especially the heaviest elements never reliably measured previously: xenon and krypton. Riding the gravity and planetary waves of Venus, the VALOR balloons would sample the chemistry, meteorology and dynamics of Venus's sulfur-cloud region. Tracked by an array of Earth-based telescopes, zonal, meridional, and vertical winds would be measured with unprecedented precision. Such measurements would help to develop a fundamental understanding of (1) the circulation of Venus, especially its enigmatic super-rotation, (2) the nature of Venus's sulfur cycle, key to Venus's current climate, and (3) how Venus formed and evolved over the aeons.

  6. The Escape of Cancer from T Cell-Mediated Immune Surveillance: HLA Class I Loss and Tumor Tissue Architecture

    Science.gov (United States)

    Garrido, Federico; Perea, Francisco; Bernal, Mónica; Sánchez-Palencia, Abel; Aptsiauri, Natalia; Ruiz-Cabello, Francisco

    2017-01-01

    Tumor immune escape is associated with the loss of tumor HLA class I (HLA-I) expression commonly found in malignant cells. Accumulating evidence suggests that the efficacy of immunotherapy depends on the expression levels of HLA class I molecules on tumors cells. It also depends on the molecular mechanism underlying the loss of HLA expression, which could be reversible/“soft” or irreversible/“hard” due to genetic alterations in HLA, β2-microglobulin or IFN genes. Immune selection of HLA-I negative tumor cells harboring structural/irreversible alterations has been demonstrated after immunotherapy in cancer patients and in experimental cancer models. Here, we summarize recent findings indicating that tumor HLA-I loss also correlates with a reduced intra-tumor T cell infiltration and with a specific reorganization of tumor tissue. T cell immune selection of HLA-I negative tumors results in a clear separation between the stroma and the tumor parenchyma with leucocytes, macrophages and other mononuclear cells restrained outside the tumor mass. Better understanding of the structural and functional changes taking place in the tumor microenvironment may help to overcome cancer immune escape and improve the efficacy of different immunotherapeutic strategies. We also underline the urgent need for designing strategies to enhance tumor HLA class I expression that could improve tumor rejection by cytotoxic T-lymphocytes (CTL). PMID:28264447

  7. The Escape of Cancer from T Cell-Mediated Immune Surveillance: HLA Class I Loss and Tumor Tissue Architecture

    Directory of Open Access Journals (Sweden)

    Federico Garrido

    2017-02-01

    Full Text Available Tumor immune escape is associated with the loss of tumor HLA class I (HLA-I expression commonly found in malignant cells. Accumulating evidence suggests that the efficacy of immunotherapy depends on the expression levels of HLA class I molecules on tumors cells. It also depends on the molecular mechanism underlying the loss of HLA expression, which could be reversible/“soft” or irreversible/“hard” due to genetic alterations in HLA, β2-microglobulin or IFN genes. Immune selection of HLA-I negative tumor cells harboring structural/irreversible alterations has been demonstrated after immunotherapy in cancer patients and in experimental cancer models. Here, we summarize recent findings indicating that tumor HLA-I loss also correlates with a reduced intra-tumor T cell infiltration and with a specific reorganization of tumor tissue. T cell immune selection of HLA-I negative tumors results in a clear separation between the stroma and the tumor parenchyma with leucocytes, macrophages and other mononuclear cells restrained outside the tumor mass. Better understanding of the structural and functional changes taking place in the tumor microenvironment may help to overcome cancer immune escape and improve the efficacy of different immunotherapeutic strategies. We also underline the urgent need for designing strategies to enhance tumor HLA class I expression that could improve tumor rejection by cytotoxic T-lymphocytes (CTL.

  8. Architectural Theatricality

    DEFF Research Database (Denmark)

    Tvedebrink, Tenna Doktor Olsen

    and well-being, as well as outline a set of basic design principles ‘predicting’ the future interior architectural qualities of patient eating environments. Methodologically the thesis is based on an explorative study employing an abductive approach and hermeneutic-interpretative strategy utilizing tactics......This PhD thesis is motived by a personal interest in the theoretical, practical and creative qualities of architecture. But also a wonder and curiosity about the cultural and social relations architecture represents through its occupation with both the sciences and the arts. Inspired by present...... initiatives in Aalborg Hospital to overcome patient undernutrition by refurbishing eating environments, this thesis engages in an investigation of the interior architectural qualities of patient eating environments. The relevance for this holistic perspective, synthesizing health, food and architecture...

  9. Architecture as Design Study.

    Science.gov (United States)

    Kauppinen, Heta

    1989-01-01

    Explores the use of analogies in architectural design, the importance of Gestalt theory and aesthetic cannons in understanding and being sensitive to architecture. Emphasizes the variation between public and professional appreciation of architecture. Notes that an understanding of architectural process enables students to improve the aesthetic…

  10. Humanizing Architecture

    DEFF Research Database (Denmark)

    Toft, Tanya Søndergaard

    2015-01-01

    The article proposes the urban digital gallery as an opportunity to explore the relationship between ‘human’ and ‘technology,’ through the programming of media architecture. It takes a curatorial perspective when proposing an ontological shift from considering media facades as visual spectacles...... agency and a sense of being by way of dematerializing architecture. This is achieved by way of programming the symbolic to provide new emotional realizations and situations of enlightenment in the public audience. This reflects a greater potential to humanize the digital in media architecture....

  11. Phenylboronic acid-sugar grafted polymer architecture as a dual stimuli-responsive gene carrier for targeted anti-angiogenic tumor therapy.

    Science.gov (United States)

    Kim, Jinhwan; Lee, Yeong Mi; Kim, Hyunwoo; Park, Dongsik; Kim, Jihoon; Kim, Won Jong

    2016-01-01

    We present a cationic polymer architecture composed of phenylboronic acid (PBA), sugar-installed polyethylenimine (PEI), and polyethylene glycol (PEG). The chemical bonding of PBA with the diol in the sugar enabled the crosslinking of low-molecular-weight (MW) PEI to form high-MW PEI, resulting in strong interaction with anionic DNA for gene delivery. Inside the cell, the binding of PBA and sugar was disrupted by either acidic endosomal pH or intracellular ATP, so gene payloads were released effectively. This dual stimuli-responsive gene release drove the polymer to deliver DNA for high transfection efficiency with low cytotoxicity. In addition, PBA moiety with PEGylation facilitated the binding of polymer/DNA polyplexes to sialylated glycoprotein which is overexpressed on the tumor cell membrane, and thus provided high tumor targeting ability. Therapeutic application of our polymer was demonstrated as an anti-angiogenic gene delivery agent for tumor growth inhibition. Our judicious designed polymer structure based on PBA provides enormous potential as a gene delivery agent for effective gene therapy by stimuli-responsiveness and tumor targeting.

  12. Exploring Drug Dosing Regimens In Vitro Using Real-Time 3D Spheroid Tumor Growth Assays.

    Science.gov (United States)

    Lal-Nag, Madhu; McGee, Lauren; Titus, Steven A; Brimacombe, Kyle; Michael, Sam; Sittampalam, Gurusingham; Ferrer, Marc

    2017-03-01

    Two-dimensional monolayer cell proliferation assays for cancer drug discovery have made the implementation of large-scale screens feasible but only seem to reflect a simplified view that oncogenes or tumor suppressor genes are the genetic drivers of cancer cell proliferation. However, there is now increased evidence that the cellular and physiological context in which these oncogenic events occur play a key role in how they drive tumor growth in vivo and, therefore, in how tumors respond to drug treatments. In vitro 3D spheroid tumor models are being developed to better mimic the physiology of tumors in vivo, in an attempt to improve the predictability and efficiency of drug discovery for the treatment of cancer. Here we describe the establishment of a real-time 3D spheroid growth, 384-well screening assay. The cells used in this study constitutively expressed green fluorescent protein (GFP), which enabled the real-time monitoring of spheroid formation and the effect of chemotherapeutic agents on spheroid size at different time points of sphere growth and drug treatment. This real-time 3D spheroid assay platform represents a first step toward the replication in vitro of drug dosing regimens being investigated in vivo. We hope that further development of this assay platform will allow the investigation of drug dosing regimens, efficacy, and resistance before preclinical and clinical studies.

  13. Exploring the Potential of (99m)Tc(CO)3-Labeled Triazolyl Peptides for Tumor Diagnosis.

    Science.gov (United States)

    Gaonkar, Raghuvir H; Ganguly, Soumya; Baishya, Rinku; Dewanjee, Saikat; Sinha, Samarendu; Gupta, Amit; Ganguly, Shantanu; Debnath, Mita C

    2016-04-01

    In recent years the authors have reported on (99m)Tc(CO)3-labeled peptides that serve as carriers for biomolecules or radiopharmaceuticals to the tumors. In continuation of that work they report the synthesis of a pentapeptide (Met-Phe-Phe-Gly-His; pep-1), a hexapeptide (Met-Phe-Phe-Asp-Gly-His; pep-2), and a tetrapeptide (Asp-Gly-Arg-His; pep-3) and the attachment of 3-amino-1,2,4-triazole to the β carboxylic function of the aspartic acid unit of pep-2 and pep-3. The pharmacophores were radiolabeled in high yields with [(99m)Tc(CO)3(H2O)3](+) metal aqua ion, characterized for their stability in serum and saline, as well as in His solution, and found to be substantially stable. B16F10 cell line binding studies showed favorable uptake and internalization. In vivo behavior of the radiolabeled triazolyl peptides was assessed in mice bearing induced tumor. The (99m)Tc(CO)3-triazolyl pep-3 demonstrated rapid urinary clearance and comparatively better tumor uptake. Imaging studies showed visualization of the tumor using (99m)Tc(CO)3-triazolyl pep-3, but due to high abdominal background, low delineation occurred. Based on the results further experiments will be carried out for targeting tumor with triazolyl peptides.

  14. Explorative study on the aftercare of pediatric brain tumor survivors: a parents' perspective

    NARCIS (Netherlands)

    Aukema, E.J.; Last, B.F.; Schouten-van Meeteren, A.Y.N.; Grootenhuis, M.A.

    2011-01-01

    Whilst the need for aftercare for long-term sequelae of brain tumor survivors is well known and evident, information from a parent's perspective is lacking on whether the need for aftercare is detected in time, and whether the aftercare is timely initiated and meets the needs for aftercare. A survey

  15. Exploration of preprocessing architectures for field-programmable gate array-based thermal-visual smart camera

    Science.gov (United States)

    Imran, Muhammad; Rinner, Bernhard; Zand, Sajjad Zandi; O'Nils, Mattias

    2016-07-01

    Embedded smart cameras are gaining in popularity for a number of real-time outdoor surveillance applications. However, there are still challenges, i.e., computational latency, variation in illumination, and occlusion. To solve these challenges, multimodal systems, integrating multiple imagers can be utilized. However, trade-off is more stringent requirements on processing and communication for embedded platforms. To meet these challenges, we investigated two low-complexity and high-performance preprocessing architectures for a multiple imagers' node on a field-programmable gate array (FPGA). In the proposed architectures, majority of the tasks are performed on the thermal images because of the lower spatial resolution. Analysis with different sets of images show that the system with proposed architectures offers better detection performance and can reduce output data from 1.7 to 99 times as compared with full-size images. The proposed architectures can achieve a frame rate of 53 fps, logics utilization from 2.1% to 4.1%, memory consumption 987 to 148 KB and power consumption in the range of 141 to 163 mW on Artix-7 FPGA. This concludes that the proposed architectures offer reduced design complexity and lower processing and communication requirements while retaining the configurability of the system.

  16. On exploration for architectural innovation of Paul Andreu%保罗·安德鲁建筑创意探讨

    Institute of Scientific and Technical Information of China (English)

    潘国柱

    2015-01-01

    通过对法国建筑师保罗·安德鲁近期在中国的建筑作品的阅读和参观,分析了广州新体育馆、上海东方艺术中心、北京国家大剧院的建筑特点,回顾了其创作的过程,探讨各建筑的创意,对现代建筑设计具有借鉴意义。%According to the reading and visiting the architectural works of Paul Andreu,French architect,in China,the paper analyzes the archi-tectural characteristic of New Stadium in Guangzhou,Shanghai Oriental Art Center,and National Grand Theater in Beijing,and reviews its inno-vation process,and explores the architectural innovation of these buildings,so it provides reference for modern architectural design.

  17. TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data

    Science.gov (United States)

    Roth, Andrew; Khattra, Jaswinder; Ho, Julie; Yap, Damian; Prentice, Leah M.; Melnyk, Nataliya; McPherson, Andrew; Bashashati, Ali; Laks, Emma; Biele, Justina; Ding, Jiarui; Le, Alan; Rosner, Jamie; Shumansky, Karey; Marra, Marco A.; Gilks, C. Blake; Huntsman, David G.; McAlpine, Jessica N.; Aparicio, Samuel

    2014-01-01

    The evolution of cancer genomes within a single tumor creates mixed cell populations with divergent somatic mutational landscapes. Inference of tumor subpopulations has been disproportionately focused on the assessment of somatic point mutations, whereas computational methods targeting evolutionary dynamics of copy number alterations (CNA) and loss of heterozygosity (LOH) in whole-genome sequencing data remain underdeveloped. We present a novel probabilistic model, TITAN, to infer CNA and LOH events while accounting for mixtures of cell populations, thereby estimating the proportion of cells harboring each event. We evaluate TITAN on idealized mixtures, simulating clonal populations from whole-genome sequences taken from genomically heterogeneous ovarian tumor sites collected from the same patient. In addition, we show in 23 whole genomes of breast tumors that the inference of CNA and LOH using TITAN critically informs population structure and the nature of the evolving cancer genome. Finally, we experimentally validated subclonal predictions using fluorescence in situ hybridization (FISH) and single-cell sequencing from an ovarian cancer patient sample, thereby recapitulating the key modeling assumptions of TITAN. PMID:25060187

  18. Preliminary Exploration of Next Generation Network Architecture%下一代网络体系结构初探

    Institute of Scientific and Technical Information of China (English)

    张炜; 陈晨

    2013-01-01

    This paper introduces the developement history and current situation of the Internet architecture. Then it makes a de scription and comparison of the research direction of the next internet architecture.At last it proposes a metheod based on net work service model to design the next internet architecture and also gives the model and the requirement. Re sult shows that Ipv6 maybe the core of the next internet architecture .%该文首先介绍了互联网体系结构的发展历程和现状,其次对下一代互联网体系结构的研究方向进行了阐述和比较.最后提出基于网络使用模型这一方式来进行互联网体系结构的设计,并给出了模型和要求,得出IPv6可能是下一代互联网体系结构的核心.

  19. Architectural Anthropology

    DEFF Research Database (Denmark)

    Stender, Marie

    Architecture and anthropology have always had a common focus on dwelling, housing, urban life and spatial organisation. Current developments in both disciplines make it even more relevant to explore their boundaries and overlaps. Architects are inspired by anthropological insights and methods......, while recent material and spatial turns in anthropology have also brought an increasing interest in design, architecture and the built environment. Understanding the relationship between the social and the physical is at the heart of both disciplines, and they can obviously benefit from further...... collaboration: How can qualitative anthropological approaches contribute to contemporary architecture? And just as importantly: What can anthropologists learn from architects’ understanding of spatial and material surroundings? Recent theoretical developments in anthropology stress the role of materials...

  20. PhyloPro2.0: a database for the dynamic exploration of phylogenetically conserved proteins and their domain architectures across the Eukarya.

    Science.gov (United States)

    Cromar, Graham L; Zhao, Anthony; Xiong, Xuejian; Swapna, Lakshmipuram S; Loughran, Noeleen; Song, Hongyan; Parkinson, John

    2016-01-01

    PhyloPro is a database and accompanying web-based application for the construction and exploration of phylogenetic profiles across the Eukarya. In this update article, we present six major new developments in PhyloPro: (i) integration of Pfam-A domain predictions for all proteins; (ii) new summary heatmaps and detailed level views of domain conservation; (iii) an interactive, network-based visualization tool for exploration of domain architectures and their conservation; (iv) ability to browse based on protein functional categories (GOSlim); (v) improvements to the web interface to enhance drill down capability from the heatmap view; and (vi) improved coverage including 164 eukaryotes and 12 reference species. In addition, we provide improved support for downloading data and images in a variety of formats. Among the existing tools available for phylogenetic profiles, PhyloPro provides several innovative domain-based features including a novel domain adjacency visualization tool. These are designed to allow the user to identify and compare proteins with similar domain architectures across species and thus develop hypotheses about the evolution of lineage-specific trajectories. Database URL: http://www.compsysbio.org/phylopro/.

  1. Architecture on Architecture

    DEFF Research Database (Denmark)

    Olesen, Karen

    2016-01-01

    This paper will discuss the challenges faced by architectural education today. It takes as its starting point the double commitment of any school of architecture: on the one hand the task of preserving the particular knowledge that belongs to the discipline of architecture, and on the other hand...... that is not scientific or academic but is more like a latent body of data that we find embedded in existing works of architecture. This information, it is argued, is not limited by the historical context of the work. It can be thought of as a virtual capacity – a reservoir of spatial configurations that can...... the autonomy of architecture, not as an esoteric concept but as a valid source of information in a pragmatic design practice, may help us overcome the often-proclaimed dichotomy between formal autonomy and a societally committed architecture. It follows that in architectural education there can be a close...

  2. Time · Space · Architecture

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    In the 20th century a Swiss writer wrote a book titled Time, Space and Architecture, in which he discussed the relationship between architecture and the times. Fifty years after that, this paper adopts the same title, hoping to deepen the understanding of the space-time structure in architecture and contribute to the new exploration of architectural forms.

  3. Exploration and practice of design based on Arnheim's architecture space ideas%阿恩海姆建筑空间观下的设计实践与探索

    Institute of Scientific and Technical Information of China (English)

    崔育新; 邱文明

    2013-01-01

    Arnheim' s architecture space idea focuses attention on the perception characters of architecture space, emphasizes on whole architecture space imagine, explains architecture space implication with visual dynamics. Based on visual dynamics, the thesis researches practice of design and explores art expression in regionalism of architecture.%阿恩海姆的建筑空间观关注建筑空间的视知觉属性,强调建筑的整体空间意象,用视知觉动力阐释建筑空间意蕴.本文以视觉动力学为基础进行设计实践研究,探索建筑地域性的艺术表现.

  4. In-Space Propulsion Engine Architecture Based on Sublimation of Planetary Resources: From Exploration Robots to NED Mitigation

    Science.gov (United States)

    Sibille, Laurent; Mantovani, James; Dominquez, Jesus

    2011-01-01

    The purpose of this NIAC study is to identify those volatile and mineral resources that are available on asteroids, comets, moons and planets in the solar system, and investigate methods to transform these resources into forms of power that will expand the capabilities of future robotic and human exploration missions to explore planetary bodies beyond the Moon and will mitigate hazards from NEOs. The sources of power used for deep space probe missions are usually derived from either solar panels for electrical energy, radioisotope thermal generators for thermal energy, or fuel cells and chemical reactions for chemical energy and propulsion.

  5. Exploring the Bone Proteome to Help Explain Altered Bone Remodeling and Preservation of Bone Architecture and Strength in Hibernating Marmots.

    Science.gov (United States)

    Doherty, Alison H; Roteliuk, Danielle M; Gookin, Sara E; McGrew, Ashley K; Broccardo, Carolyn J; Condon, Keith W; Prenni, Jessica E; Wojda, Samantha J; Florant, Gregory L; Donahue, Seth W

    2016-01-01

    Periods of physical inactivity increase bone resorption and cause bone loss and increased fracture risk. However, hibernating bears, marmots, and woodchucks maintain bone structure and strength, despite being physically inactive for prolonged periods annually. We tested the hypothesis that bone turnover rates would decrease and bone structural and mechanical properties would be preserved in hibernating marmots (Marmota flaviventris). Femurs and tibias were collected from marmots during hibernation and in the summer following hibernation. Bone remodeling was significantly altered in cortical and trabecular bone during hibernation with suppressed formation and no change in resorption, unlike the increased bone resorption that occurs during disuse in humans and other animals. Trabecular bone architecture and cortical bone geometrical and mechanical properties were not different between hibernating and active marmots, but bone marrow adiposity was significantly greater in hibernators. Of the 506 proteins identified in marmot bone, 40 were significantly different in abundance between active and hibernating marmots. Monoaglycerol lipase, which plays an important role in fatty acid metabolism and the endocannabinoid system, was 98-fold higher in hibernating marmots compared with summer marmots and may play a role in regulating the changes in bone and fat metabolism that occur during hibernation.

  6. A Subjective Assessment of Alternative Mission Architecture Operations Concepts for the Human Exploration of Mars at NASA Using a Three-Dimensional Multi-Criteria Decision Making Model

    Science.gov (United States)

    Tavana, Madjid

    2003-01-01

    The primary driver for developing missions to send humans to other planets is to generate significant scientific return. NASA plans human planetary explorations with an acceptable level of risk consistent with other manned operations. Space exploration risks can not be completely eliminated. Therefore, an acceptable level of cost, technical, safety, schedule, and political risks and benefits must be established for exploratory missions. This study uses a three-dimensional multi-criteria decision making model to identify the risks and benefits associated with three alternative mission architecture operations concepts for the human exploration of Mars identified by the Mission Operations Directorate at Johnson Space Center. The three alternatives considered in this study include split, combo lander, and dual scenarios. The model considers the seven phases of the mission including: 1) Earth Vicinity/Departure; 2) Mars Transfer; 3) Mars Arrival; 4) Planetary Surface; 5) Mars Vicinity/Departure; 6) Earth Transfer; and 7) Earth Arrival. Analytic Hierarchy Process (AHP) and subjective probability estimation are used to captures the experts belief concerning the risks and benefits of the three alternative scenarios through a series of sequential, rational, and analytical processes.

  7. Exploration of a capability-focused aerospace system of systems architecture alternative with bilayer design space, based on RST-SOM algorithmic methods.

    Science.gov (United States)

    Li, Zhifei; Qin, Dongliang; Yang, Feng

    2014-01-01

    In defense related programs, the use of capability-based analysis, design, and acquisition has been significant. In order to confront one of the most challenging features of a huge design space in capability based analysis (CBA), a literature review of design space exploration was first examined. Then, in the process of an aerospace system of systems design space exploration, a bilayer mapping method was put forward, based on the existing experimental and operating data. Finally, the feasibility of the foregoing approach was demonstrated with an illustrative example. With the data mining RST (rough sets theory) and SOM (self-organized mapping) techniques, the alternative to the aerospace system of systems architecture was mapping from P-space (performance space) to C-space (configuration space), and then from C-space to D-space (design space), respectively. Ultimately, the performance space was mapped to the design space, which completed the exploration and preliminary reduction of the entire design space. This method provides a computational analysis and implementation scheme for large-scale simulation.

  8. Exploration of the optimal diameter cut-off value in patients with nonfunctional adrenal tumor suitable for surgery

    Directory of Open Access Journals (Sweden)

    Dan-dan LIU

    2016-12-01

    Full Text Available Objective  To analyze the pathology of the patients with nonfunctional adrenal tumor (NFA, and explore the optimal diameter cut-off value. Methods  The clinical data of 243 patients with NFA, evaluated in the Department of Endocrinology and operated in the Department of Urology of General Hospital of Chinese PLA from Feb. 1996 to Jan. 2016, were collected. The patients were divided into two groups according to pathology: those in real demand of surgery were classified to the surgery-need group (n=57, while the others were categorized as the surgery-unwanted group (n=186. The general situation, pathological type and tumor diameter of the two groups and the factors affecting the surgery were analyzed, and the ROC curve was used to explore the optimal surgery cut-off value, which represents the maximum value of the sum of sensitivity and specificity. Results  Of the 57 patients in surgery-need group (27 males and 30 females, the lesions were on the right in 31 cases, on the left in 25 cases, and on bilateral sides in 1 case; the median of lesion diameter was 4.5cm, and the average age was 41.5±12.1 years old. Of the 186 patients in surgery-unwanted group (87 males and 99 females, the lesions were on the right in 99 cases, on the left in 86 cases, and on bilateral sides in 1 case; the median of lesion diameter was 3.0cm, and the average age was 50.6±10.9 years old. Logistic regression revealed that lesion diameter might be a risk factor (OR=1.340, 95%CI 1.266-1.418, P=0.000 and age be a protective factor (OR=0.942, 95%CI 0.929-0.955, P=0.000 for real demand of surgery. The area under the ROC curve (AUC of lesion diameter was 0.757(95%CI 0.681-0.833. The optimal cut-off value was 4.1cm (sensitivity 60.7% and specificity 83.0%. Conclusions  Younger patients with bigger lesion diameter may have greater possibility for surgery. The optimal surgery cut-off value of the lesion diameter is 4.1cm. DOI: 10.11855/j.issn.0577-7402.2016.11.11

  9. Brain tumor segmentation with Deep Neural Networks.

    Science.gov (United States)

    Havaei, Mohammad; Davy, Axel; Warde-Farley, David; Biard, Antoine; Courville, Aaron; Bengio, Yoshua; Pal, Chris; Jodoin, Pierre-Marc; Larochelle, Hugo

    2017-01-01

    In this paper, we present a fully automatic brain tumor segmentation method based on Deep Neural Networks (DNNs). The proposed networks are tailored to glioblastomas (both low and high grade) pictured in MR images. By their very nature, these tumors can appear anywhere in the brain and have almost any kind of shape, size, and contrast. These reasons motivate our exploration of a machine learning solution that exploits a flexible, high capacity DNN while being extremely efficient. Here, we give a description of different model choices that we've found to be necessary for obtaining competitive performance. We explore in particular different architectures based on Convolutional Neural Networks (CNN), i.e. DNNs specifically adapted to image data. We present a novel CNN architecture which differs from those traditionally used in computer vision. Our CNN exploits both local features as well as more global contextual features simultaneously. Also, different from most traditional uses of CNNs, our networks use a final layer that is a convolutional implementation of a fully connected layer which allows a 40 fold speed up. We also describe a 2-phase training procedure that allows us to tackle difficulties related to the imbalance of tumor labels. Finally, we explore a cascade architecture in which the output of a basic CNN is treated as an additional source of information for a subsequent CNN. Results reported on the 2013 BRATS test data-set reveal that our architecture improves over the currently published state-of-the-art while being over 30 times faster.

  10. Architecture on Architecture

    DEFF Research Database (Denmark)

    Olesen, Karen

    2016-01-01

    that is not scientific or academic but is more like a latent body of data that we find embedded in existing works of architecture. This information, it is argued, is not limited by the historical context of the work. It can be thought of as a virtual capacity – a reservoir of spatial configurations that can...... the obligation to prepare students to perform in a profession that is largely defined by forces outside that discipline. It will be proposed that the autonomy of architecture can be understood as a unique kind of information: as architecture’s self-reliance or knowledge-about itself. A knowledge...... be transformed and reapplied endlessly through its confrontation with shifting information from outside the realms of architecture. A selection of architects’ statements on their own work will be used to demonstrate how in quite diverse contemporary practices the re-use of existing architectures is applied...

  11. Aesthetics of sustainable architecture

    NARCIS (Netherlands)

    Lee, S.

    2011-01-01

    The purpose of this book is to reveal, explore and further the debate on the aesthetic potentials of sustainable architecture and its practice. This book opens a new area of scholarship and discourse in the design and production of sustainable architecture, one that is based in aesthetics. The chapt

  12. Towards a Media Architecture

    DEFF Research Database (Denmark)

    Ebsen, Tobias

    2010-01-01

    This text explores the concept of media architecture as a phenomenon of visual culture that describes the use of screen-technology in new spatial configurations in practices of architecture and art. I shall argue that this phenomenon is not necessarily a revolutionary new approach, but rather...... a result of conceptual changes in both modes visual representation and in expressions of architecture. These are changes the may be described as an evolution of ideas and consequent experiments that can be traced back to changes in the history of art and the various styles and ideologies of architecture....

  13. Elements of Architecture

    DEFF Research Database (Denmark)

    Elements of Architecture explores new ways of engaging architecture in archaeology. It conceives of architecture both as the physical evidence of past societies and as existing beyond the physical environment, considering how people in the past have not just dwelled in buildings but have existed...... and affective impacts, of these material remains. The contributions in this volume investigate the way time, performance and movement, both physically and emotionally, are central aspects of understanding architectural assemblages. It is a book about the constellations of people, places and things that emerge...

  14. Exploration of the inhibiting effect of Notch-1 blocker on tumor growth in osteosarcoma mouse models as well as related molecular mechanisms

    Institute of Scientific and Technical Information of China (English)

    Bin Zhou; Wei-Chun Guo

    2016-01-01

    Objective:To explore the inhibiting effect of Notch-1 blocker on tumor growth in osteosarcoma mouse models as well as related molecular mechanisms.Methods: SCID mice were selected as experimental subjects, and osteosarcoma mouse models were built through subcutaneous injection of osteosarcoma cells and divided into GSI group and PBS group who received GSI and PBS intervention respectively. 0 d, 5 d, 10 d, 15 d and 20 d after intervention, tumor tissue volume was detected; 20 d after intervention, the contents of pro-apoptosis, pro-proliferation and invasion-related molecules in tumor tissue were detected.Results: On the 0 d of intervention, tumor volume of GSI group was not significantly different from that of PBS group; 5 d, 10 d, 15 d and 20 d after intervention, tumor volume of GSI group was significantly lower than that of PBS group; 20 d after intervention, the contents of pro-proliferation molecules AEG-1, Orai1, STIM1, PAK5, RIPK4 andβ-catenin as well as invasion-promoting molecules Gab2, DLK1, Scr and B7-H3 in tumor tissue of GSI group were significantly lower than those of PBS group, and the contents of pro-apoptosis molecules RanBP9, PD-1, PD-L1 and PD-L2 as well as invasion-inhibiting molecules TIMP1 and TIMP2 were significantly higher than those of PBS group.Conclusion:Notch-1 blocker can inhibit tumor growth in osteosarcoma mouse models, and the molecular mechanisms involved in the process include reducing the generation of pro-proliferation molecules and invasion-promoting molecules and increasing the generation of pro-apoptosis and invasion-inhibiting molecules.

  15. Architectural slicing

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Hansen, Klaus Marius

    2013-01-01

    a system and a slicing criterion, architectural slicing produces an architectural prototype that contain the elements in the architecture that are dependent on the ele- ments in the slicing criterion. Furthermore, we present an initial design and implementation of an architectural slicer for Java.......Architectural prototyping is a widely used practice, con- cerned with taking architectural decisions through experiments with light- weight implementations. However, many architectural decisions are only taken when systems are already (partially) implemented. This is prob- lematic in the context...... of architectural prototyping since experiments with full systems are complex and expensive and thus architectural learn- ing is hindered. In this paper, we propose a novel technique for harvest- ing architectural prototypes from existing systems, \\architectural slic- ing", based on dynamic program slicing. Given...

  16. Exploration of two methods for quantitative Mitomycin C measurement in tumor tissue in vitro and in vivo

    DEFF Research Database (Denmark)

    Fischer, Lee MacKenzie; Vásquez, Juan Luis; Gehl, Julie

    2013-01-01

    be resolved using this technique in samples that do not strongly scatter light. A novel method for monitoring the Mitomycin C concentrations inside a tumor is developed, based on microdialysis and ultraviolet-visible spectroscopy. A pump is used to perfuse a microdialysis probe with Ringer’s solution, which...

  17. A MULTISTAGE BIOLOGICALLY BASED MATHEMATICAL MODEL FOR MOUSE LIVER TUMORS INDUCED BY DICHLOROACETIC ACID (DCA) - EXPLORATION OF THE MODEL

    Science.gov (United States)

    A biologically based mathematical model for the induction of liver tumors in mice by dichloroacetic acid (DCA) has been developed from histopathologic analysis of the livers of exposed mice. This analysis suggests that following chronic exposure to DCA, carcinomas can arise dire...

  18. Towards Adaptive Evolutionary Architecture

    DEFF Research Database (Denmark)

    Bak, Sebastian HOlt; Rask, Nina; Risi, Sebastian

    2016-01-01

    This paper presents first results from an interdisciplinary project, in which the fields of architecture, philosophy and artificial life are combined to explore possible futures of architecture. Through an interactive evolutionary installation, called EvoCurtain, we investigate aspects of how...... to the development of designs tailored to the individual preferences of inhabitants, changing the roles of architects and designers entirely. Architecture-as-it-could-be is a philosophical approach conducted through artistic methods to anticipate the technological futures of human-centered development within...

  19. 建筑动漫技术人才培养模式探索与研究%Exploration and Research on the Training Mode of the Architectural Animation Technology Talents

    Institute of Scientific and Technical Information of China (English)

    于沙; 周莉

    2014-01-01

    With the arrival of the modern digital age, the traditional architectural design and informatization technology are collided and integrated, which make the architectural design undergone fundamental changes. The traditional construction industry creates new architectural animation design technology in the modernization process. This technology has popularized to many fields and become the popular profession of comprehensive performance and artistic recreation in the architectural design. Therefore the architectural animation design technology will enter the level of social division of labor and become one of the technology industries with most powerful survival strength in the future. According to the requirements of the market, the specialty of architectural animation technology is established and the training mode of the professional talents are explored and researched.%当现代化数字时代到来时,传统的建筑设计与信息化技术得到碰撞和交融,使其发生了根本的改变。在现代化进程中传统的建筑行业催生出的新型建筑动漫设计技术,已推广至许多领域,成为一种建筑设计全方位表现和艺术性再创作的热门行业。因此,可以预计该技术领域的蓬勃发展趋势必将进入社会化分工层面,成为未来最具生存实力的技术行业之一,根据劳动市场需求,我们创办了建筑动漫技术专业,并对专业人才培养模式进行了探索与研究。

  20. Robotic Architectures

    Directory of Open Access Journals (Sweden)

    Mbali Mtshali

    2010-01-01

    Full Text Available In the development of mobile robotic systems, a robotic architecture plays a crucial role in interconnecting all the sub-systems and controlling the system. The design of robotic architectures for mobile autonomous robots is a challenging and complex task. With a number of existing architectures and tools to choose from, a review of the existing robotic architecture is essential. This paper surveys the different paradigms in robotic architectures. A classification of the existing robotic architectures and comparison of different proposals attributes and properties have been carried out. The paper also provides a view on the current state of designing robot architectures. It also proposes a conceptual model of a generalised robotic architecture for mobile autonomous robots.Defence Science Journal, 2010, 60(1, pp.15-22, DOI:http://dx.doi.org/10.14429/dsj.60.96

  1. Architecture & Environment

    Science.gov (United States)

    Erickson, Mary; Delahunt, Michael

    2010-01-01

    Most art teachers would agree that architecture is an important form of visual art, but they do not always include it in their curriculums. In this article, the authors share core ideas from "Architecture and Environment," a teaching resource that they developed out of a long-term interest in teaching architecture and their fascination with the…

  2. Exploration of the Landscape Architecture under Regional Culture Background%地域文化背景下的景观建筑学探讨

    Institute of Scientific and Technical Information of China (English)

    彭为清

    2014-01-01

    This article embarked from different geographical cultures, discussing the landscape architecture. The author bel-ieved that, in the current background, landscape architecture should pay at ention to its own cultural characteristics, which would be integrated into design, so landscape architectures having exuberant vitality with public identity and a sense of belonging can come into being.%本文从不同地域文化出发,探讨了景观建筑学。文章认为,在当前的大背景下,景观建筑学要注重各个地区自身的文化特色,将其融入到设计理念中,从而设计出让公众有认同感和归属感并且拥有旺盛生命力的景观建筑。

  3. Architectural freedom and industrialised architecture

    DEFF Research Database (Denmark)

    Vestergaard, Inge

    2012-01-01

    compares "best practice" in Denmark and "best practice" in Austria. The modern architects accepted the fact that industrialized architecture told the storey of repetition and monotonous as basic condition. This article aims to explain that architecture can be thought as a complex and diverse design through......Architectural freedom and industrialized architecture. Inge Vestergaard, Associate Professor, Cand. Arch. Aarhus School of Architecture, Denmark Noerreport 20, 8000 Aarhus C Telephone +45 89 36 0000 E-mai l inge.vestergaard@aarch.dk Based on the repetitive architecture from the "building boom" 1960...... to 1973 it is discussed how architects can handle these Danish element and montage buildings through the transformation to upgraded aesthetical, functional and energy efficient architecture. The method used is analysis of cases, parallels to literature studies and producer interviews. This analysis...

  4. DSP Architecture Design Essentials

    CERN Document Server

    Marković, Dejan

    2012-01-01

    In DSP Architecture Design Essentials, authors Dejan Marković and Robert W. Brodersen cover a key subject for the successful realization of DSP algorithms for communications, multimedia, and healthcare applications. The book addresses the need for DSP architecture design that maps advanced DSP algorithms to hardware in the most power- and area-efficient way. The key feature of this text is a design methodology based on a high-level design model that leads to hardware implementation with minimum power and area. The methodology includes algorithm-level considerations such as automated word-length reduction and intrinsic data properties that can be leveraged to reduce hardware complexity. From a high-level data-flow graph model, an architecture exploration methodology based on linear programming is used to create an array of architectural solutions tailored to the underlying hardware technology. The book is supplemented with online material: bibliography, design examples, CAD tutorials and custom software.

  5. Parallel Architectures and Bioinspired Algorithms

    CERN Document Server

    Pérez, José; Lanchares, Juan

    2012-01-01

    This monograph presents examples of best practices when combining bioinspired algorithms with parallel architectures. The book includes recent work by leading researchers in the field and offers a map with the main paths already explored and new ways towards the future. Parallel Architectures and Bioinspired Algorithms will be of value to both specialists in Bioinspired Algorithms, Parallel and Distributed Computing, as well as computer science students trying to understand the present and the future of Parallel Architectures and Bioinspired Algorithms.

  6. Towards an Architectural Anthropology

    DEFF Research Database (Denmark)

    Stender, Marie

    2016-01-01

    their overlaps and collaboration. However, there are also challenging differences to take into account regarding disciplinary traditions of, for example, communication, temporality, and normativity. This article explores the potentials and challenges of architectural anthropology as a distinct sub......Architecture and anthropology have always had overlapping interests regarding issues such as spatial organisation, forms of human dwellings, and the interplay between social life and physical surroundings. Recent developments in both disciplines make it even more relevant to explore and evolve......-discipline and outlines its possible theoretical, methodological, and applied contributions. It is proposed that the ambition to understand people in a different way than they understand themselves is key in both disciplines, and that architectural anthropology is consequently not only relevant in studies of vernacular...

  7. Towards an Architectural Anthropology

    DEFF Research Database (Denmark)

    Stender, Marie

    2016-01-01

    Architecture and anthropology have always had overlapping interests regarding issues such as spatial organisation, forms of human dwellings, and the interplay between social life and physical surroundings. Recent developments in both disciplines make it even more relevant to explore and evolve...... their overlaps and collaboration. However, there are also challenging differences to take into account regarding disciplinary traditions of, for example, communication, temporality, and normativity. This article explores the potentials and challenges of architectural anthropology as a distinct sub......-discipline and outlines its possible theoretical, methodological, and applied contributions. It is proposed that the ambition to understand people in a different way than they understand themselves is key in both disciplines, and that architectural anthropology is consequently not only relevant in studies of vernacular...

  8. Software architecture

    CERN Document Server

    Vogel, Oliver; Chughtai, Arif

    2011-01-01

    As a software architect you work in a wide-ranging and dynamic environment. You have to understand the needs of your customer, design architectures that satisfy both functional and non-functional requirements, and lead development teams in implementing the architecture. And it is an environment that is constantly changing: trends such as cloud computing, service orientation, and model-driven procedures open up new architectural possibilities. This book will help you to develop a holistic architectural awareness and knowledge base that extends beyond concrete methods, techniques, and technologi

  9. Green Architecture

    Science.gov (United States)

    Lee, Seung-Ho

    Today, the environment has become a main subject in lots of science disciplines and the industrial development due to the global warming. This paper presents the analysis of the tendency of Green Architecture in France on the threes axes: Regulations and Approach for the Sustainable Architecture (Certificate and Standard), Renewable Materials (Green Materials) and Strategies (Equipments) of Sustainable Technology. The definition of 'Green Architecture' will be cited in the introduction and the question of the interdisciplinary for the technological development in 'Green Architecture' will be raised up in the conclusion.

  10. Integrating the molecular background of targeted therapy and immunotherapy in lung cancer: a way to explore the impact of mutational landscape on tumor immunogenicity

    Science.gov (United States)

    Pilotto, Sara; Molina-Vila, Miguel Angel; Karachaliou, Niki; Carbognin, Luisa; Viteri, Santiago; González-Cao, Maria; Bria, Emilio; Tortora, Giampaolo

    2015-01-01

    The results of randomized clinical trials employing immune checkpoint inhibitors for pre-treated advanced non-small-cell lung cancer (NSCLC) have recently revolutionised the standard available option for this disease setting. Nevertheless, the validation of reliable predictive biomarkers, able to define that proportion of patients most likely to benefit from immunotherapy, represents a crucial and still unsolved issue. This intensive research aimed at selecting potentially predictive biomarkers for immunotherapy is developed together with a wide range of analyses investigating the molecular profiling of lung cancer, leading to the spontaneous question of how these two parallel aspects of the same disease may coexist and influence one another. The potential impact of the mutational landscape of lung cancer on tumor immunogenicity (in both oncogene-addicted and molecularly unselected disease) will be explored and discussed in this review in order to begin to answer the unsolved questions. PMID:26798581

  11. Transcriptional Network Architecture of Breast Cancer Molecular Subtypes

    Science.gov (United States)

    de Anda-Jáuregui, Guillermo; Velázquez-Caldelas, Tadeo E.; Espinal-Enríquez, Jesús; Hernández-Lemus, Enrique

    2016-01-01

    Breast cancer heterogeneity is evident at the clinical, histological and molecular level. High throughput technologies allowed the identification of intrinsic subtypes that capture transcriptional differences among tumors. A remaining question is whether said differences are associated to a particular transcriptional program which involves different connections between the same molecules. In other words, whether particular transcriptional network architectures can be linked to specific phenotypes. In this work we infer, construct and analyze transcriptional networks from whole-genome gene expression microarrays, by using an information theory approach. We use 493 samples of primary breast cancer tissue classified in four molecular subtypes: Luminal A, Luminal B, Basal and HER2-enriched. For comparison, a network for non-tumoral mammary tissue (61 samples) is also inferred and analyzed. Transcriptional networks present particular architectures in each breast cancer subtype as well as in the non-tumor breast tissue. We find substantial differences between the non-tumor network and those networks inferred from cancer samples, in both structure and gene composition. More importantly, we find specific network architectural features associated to each breast cancer subtype. Based on breast cancer networks' centrality, we identify genes previously associated to the disease, either, generally (i.e., CNR2) or to a particular subtype (such as LCK). Similarly, we identify LUZP4, a gene barely explored in breast cancer, playing a role in transcriptional networks with subtype-specific relevance. With this approach we observe architectural differences between cancer and non-cancer at network level, as well as differences between cancer subtype networks which might be associated with breast cancer heterogeneity. The centrality measures of these networks allow us to identify genes with potential biomedical implications to breast cancer. PMID:27920729

  12. Transcriptional Network Architecture of Breast Cancer Molecular Subtypes

    Directory of Open Access Journals (Sweden)

    Guillermo de Anda-Jáuregui

    2016-11-01

    Full Text Available Breast cancer heterogeneity is evident at the clinical, histological and molecular level. High throughput technologies allowed the identification of intrinsic subtypes that capture transcriptional differences among tumors. A remaining question is whether said differences are associated to a particular transcriptional program which involves different connections between the same molecules. In other words, whether particular transcriptional network architectures can be linked to specific phenotypes.In this work we infer, construct and analyze transcriptional networks from whole-genome gene expression microarrays, by using an information theory approach. We use 493 samples of primary breast cancer tissue classified in four molecular subtypes: Luminal A, Luminal B, Basal and HER2-enriched. For comparison, a network for non-tumoral mammary tissue (61 samples is also inferred and analyzed.Transcriptional networks present particular architectures in each breast cancer subtype as well as in the non-tumor breast tissue. We find substantial differences between the non-tumor network and those networks inferred from cancer samples, in both structure and gene composition. More importantly, we find specific network architectural features associated to each breast cancer subtype. Based on breast cancer networks' centrality, we identify genes previously associated to the disease, either, generally (i.e. CNR2 or to a particular subtype (such as LCK. Similarly, we identify LUZP4, a gene barely explored in breast cancer, playing a role in transcriptional networks with subtype-specific relevance.With this approach we observe architectural differences between cancer and non-cancer at network level, as well as differences between cancer subtype networks which might be associated with breast cancer heterogeneity. The centrality measures of these networks allow us to identify genes with potential biomedical implications to breast cancer.

  13. Transcriptional Network Architecture of Breast Cancer Molecular Subtypes.

    Science.gov (United States)

    de Anda-Jáuregui, Guillermo; Velázquez-Caldelas, Tadeo E; Espinal-Enríquez, Jesús; Hernández-Lemus, Enrique

    2016-01-01

    Breast cancer heterogeneity is evident at the clinical, histological and molecular level. High throughput technologies allowed the identification of intrinsic subtypes that capture transcriptional differences among tumors. A remaining question is whether said differences are associated to a particular transcriptional program which involves different connections between the same molecules. In other words, whether particular transcriptional network architectures can be linked to specific phenotypes. In this work we infer, construct and analyze transcriptional networks from whole-genome gene expression microarrays, by using an information theory approach. We use 493 samples of primary breast cancer tissue classified in four molecular subtypes: Luminal A, Luminal B, Basal and HER2-enriched. For comparison, a network for non-tumoral mammary tissue (61 samples) is also inferred and analyzed. Transcriptional networks present particular architectures in each breast cancer subtype as well as in the non-tumor breast tissue. We find substantial differences between the non-tumor network and those networks inferred from cancer samples, in both structure and gene composition. More importantly, we find specific network architectural features associated to each breast cancer subtype. Based on breast cancer networks' centrality, we identify genes previously associated to the disease, either, generally (i.e., CNR2) or to a particular subtype (such as LCK). Similarly, we identify LUZP4, a gene barely explored in breast cancer, playing a role in transcriptional networks with subtype-specific relevance. With this approach we observe architectural differences between cancer and non-cancer at network level, as well as differences between cancer subtype networks which might be associated with breast cancer heterogeneity. The centrality measures of these networks allow us to identify genes with potential biomedical implications to breast cancer.

  14. Local architecture

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Local architecture refers to structures built in the countryside,such as temples,memorial halls,residences, stores,pavilions, bridges,decorated archways, and wells. Because these structures were all built by focal craftsmen and villagers in the traditional local style, they are generally called local architecture.

  15. Architecture Sustainability

    NARCIS (Netherlands)

    Avgeriou, Paris; Stal, Michael; Hilliard, Rich

    2013-01-01

    Software architecture is the foundation of software system development, encompassing a system's architects' and stakeholders' strategic decisions. A special issue of IEEE Software is intended to raise awareness of architecture sustainability issues and increase interest and work in the area. The fir

  16. Architectural Contestation

    NARCIS (Netherlands)

    Merle, J.

    2012-01-01

    This dissertation addresses the reductive reading of Georges Bataille's work done within the field of architectural criticism and theory which tends to set aside the fundamental ‘broken’ totality of Bataille's oeuvre and also to narrowly interpret it as a mere critique of architectural form, consequ

  17. Architectural geometry

    NARCIS (Netherlands)

    Pottmann, Helmut; Eigensatz, Michael; Vaxman, A.; Wallner, Johannes

    2015-01-01

    Around 2005 it became apparent in the geometry processing community that freeform architecture contains many problems of a geometric nature to be solved, and many opportunities for optimization which however require geometric understanding. This area of research, which has been called architectural

  18. Architectural Narratives

    DEFF Research Database (Denmark)

    Kiib, Hans

    2010-01-01

    and architectural heritage; another group tries to embed new performative technologies in expressive architectural representation. Finally, this essay provides a theoretical framework for the analysis of the political rationales of these projects and for the architectural representation bridges the gap between......In this essay, I focus on the combination of programs and the architecture of cultural projects that have emerged within the last few years. These projects are characterized as “hybrid cultural projects,” because they intend to combine experience with entertainment, play, and learning. This essay...... identifies new rationales related to this development, and it argues that “cultural planning” has increasingly shifted its focus from a cultural institutional approach to a more market-oriented strategy that integrates art and business. The role of architecture has changed, too. It not only provides...

  19. Architectural Theatricality

    DEFF Research Database (Denmark)

    Tvedebrink, Tenna Doktor Olsen

    This PhD thesis is motived by a personal interest in the theoretical, practical and creative qualities of architecture. But also a wonder and curiosity about the cultural and social relations architecture represents through its occupation with both the sciences and the arts. Inspired by present...... initiatives in Aalborg Hospital to overcome patient undernutrition by refurbishing eating environments, this thesis engages in an investigation of the interior architectural qualities of patient eating environments. The relevance for this holistic perspective, synthesizing health, food and architecture...... environments and a knowledge gap therefore exists in present hospital designs. Consequently, the purpose of this thesis has been to investigate if any research-based knowledge exist supporting the hypothesis that the interior architectural qualities of eating environments influence patient food intake, health...

  20. 民用建筑中结构节能设计研究%Explore the Structure Energy Efficiency Design of Civil Architecture

    Institute of Scientific and Technical Information of China (English)

    谭宁希; 王成立

    2013-01-01

    能源资源的匮乏使节能成为了一个国家的基本政策,在民用建筑中采用节能结构设计,有助于保护环境,实现社会可持续发展目的。本文主要研究了民用建筑中的结构节能设计,可以缓解我国能源紧张问题,促进经济发展。%The scarcity of energy resources results in the ener-gy saving becomes the basic policy of country. In civil archit-ecture, adopting the energy-saving structural design can help to protect the environment and achieve the sustainable developm-ent of society. This article mainly studies the structure energy-saving design in civil architecture, which can ease the problem of energy shortage and promote the economic development.

  1. Architectural Prototyping in Industrial Practice

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Hansen, Klaus Marius

    2008-01-01

    Architectural prototyping is the process of using executable code to investigate stakeholders’ software architecture concerns with respect to a system under development. Previous work has established this as a useful and cost-effective way of exploration and learning of the design space of a system......, in addressing issues regarding quality attributes, in addressing architectural risks, and in addressing the problem of knowledge transfer and conformance. Little work has been reported so far on the actual industrial use of architectural prototyping. In this paper, we report from an ethnographical study...... prototypes include end-user or business related functionality rather than purely architectural functionality. Based on these observations we provide recommendations for effective industrial architectural prototyping....

  2. Architectural technology

    DEFF Research Database (Denmark)

    2005-01-01

    The booklet offers an overall introduction to the Institute of Architectural Technology and its projects and activities, and an invitation to the reader to contact the institute or the individual researcher for further information. The research, which takes place at the Institute of Architectural...... Technology at the Roayl Danish Academy of Fine Arts, School of Architecture, reflects a spread between strategic, goal-oriented pilot projects, commissioned by a ministry, a fund or a private company, and on the other hand projects which originate from strong personal interests and enthusiasm of individual...

  3. An architectural approach to level design

    CERN Document Server

    Totten, Christopher W

    2014-01-01

    Explore Level Design through the Lens of Architectural and Spatial Experience TheoryWritten by a game developer and professor trained in architecture, An Architectural Approach to Level Design is one of the first books to integrate architectural and spatial design theory with the field of level design. It explores the principles of level design through the context and history of architecture, providing information useful to both academics and game development professionals.Understand Spatial Design Principles for Game Levels in 2D, 3D, and Multiplayer ApplicationsThe book presents architectura

  4. Molecular rheology of branched polymers: Decoding and exploring the role of architectural dispersity through a synergy of anionic synthesis, interaction chromatography, rheometry and modeling

    KAUST Repository

    Van Ruymbeke, Evelyne

    2014-01-01

    An emerging challenge in polymer physics is the quantitative understanding of the influence of a macromolecular architecture (i.e., branching) on the rheological response of entangled complex polymers. Recent investigations of the rheology of well-defined architecturally complex polymers have determined the composition in the molecular structure and identified the role of side-products in the measured samples. The combination of different characterization techniques, experimental and/or theoretical, represents the current state-of-the-art. Here we review this interdisciplinary approach to molecular rheology of complex polymers, and show the importance of confronting these different tools for ensuring an accurate characterization of a given polymeric sample. We use statistical tools in order to relate the information available from the synthesis protocols of a sample and its experimental molar mass distribution (typically obtained from size exclusion chromatography), and hence obtain precise information about its structural composition, i.e. enhance the existing sensitivity limit. We critically discuss the use of linear rheology as a reliable quantitative characterization tool, along with the recently developed temperature gradient interaction chromatography. The latter, which has emerged as an indispensable characterization tool for branched architectures, offers unprecedented sensitivity in detecting the presence of different molecular structures in a sample. Combining these techniques is imperative in order to quantify the molecular composition of a polymer and its consequences on the macroscopic properties. We validate this approach by means of a new model asymmetric comb polymer which was synthesized anionically. It was thoroughly characterized and its rheology was carefully analyzed. The main result is that the rheological signal reveals fine molecular details, which must be taken into account to fully elucidate the viscoelastic response of entangled branched

  5. Architectural Engineers

    DEFF Research Database (Denmark)

    Petersen, Rikke Premer

    engineering is addresses from two perspectives – as an educational response and an occupational constellation. Architecture and engineering are two of the traditional design professions and they frequently meet in the occupational setting, but at educational institutions they remain largely estranged......The design professions have always been an amorphous phenomena difficult to merge under one label. New constellations continually emerge, questioning, stretching, and reconfiguring the understanding of design and the professional practices linked to it. In this paper the idea of architectural....... The paper builds on a multi-sited study of an architectural engineering program at the Technical University of Denmark and an architectural engineering team within an international engineering consultancy based on Denmark. They are both responding to new tendencies within the building industry where...

  6. Architectural Mealscapes

    DEFF Research Database (Denmark)

    Tvedebrink, Tenna Doktor Olsen; Fisker, Anna Marie; Kirkegaard, Poul Henning

    2012-01-01

    the German architect Gottfried Semper developed a theory on the “four elements of Architecture” tracing the origin of architecture back to the rise of the early human settlement and the creation of fire. With the notion ‘hearth’ as the first motive in architecture and the definition of three enclosing...... motives; mounding, enclosure and roof, Semper linked the cultural and social values of the primordial fireplace with the order and shape of architecture. He claimed that any building ever made was nothing but a variation of the first primitive shelters erected around the fireplace, and that the three...... enclosing motives existed only as defenders of the “sacred flame”. In that way Semper developed the idea that any architectural scenery can be described, analyzed and explained by understanding the contextual, symbolic and social values of how the four basic motives of hearth, mounding, enclosure, and roof...

  7. Systemic Architecture

    DEFF Research Database (Denmark)

    Poletto, Marco; Pasquero, Claudia

    2012-01-01

    design protocols developed to describe the city as a territory of self-organization. Collecting together nearly a decade of design experiments by the authors and their practice, ecoLogicStudio, the book discusses key disciplinary definitions such as ecologic urbanism, algorithmic architecture, bottom......-up or tactical design, behavioural space and the boundary of the natural and the artificial realms within the city and architecture. A new kind of "real-time world-city" is illustrated in the form of an operational design manual for the assemblage of proto-architectures, the incubation of proto......-gardens and the coding of proto-interfaces. These prototypes of machinic architecture materialize as synthetic hybrids embedded with biological life (proto-gardens), computational power, behavioural responsiveness (cyber-gardens), spatial articulation (coMachines and fibrous structures), remote sensing (FUNclouds...

  8. 地下室人防建筑设计要点探究%Explore the Design Points of Civil Air Defense Architectural of Basement

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    With the rapid development of the construction in-dustry, the function of basement has a strong comprehensiven-ess, in addition to air defense requirements, as wel as the need for normal use, such as parking, and equipment. In this article, the author gives a detailed and in-depth discussion of the rel-evant points of civil air defense architectural design of basem-ent.%  随着建筑行业的快速发展,地下室的功能有着较强的综合性。除了防空要求,还有平时使用的需要,如停车,设备等。本文就地下室人防建筑设计的相关要点进行了细致、深入的探讨。

  9. 汉画像折射出的宗教信仰探析%The Exploration of Religious Belief in Han Dynasty Architecture

    Institute of Scientific and Technical Information of China (English)

    刘芳

    2011-01-01

    During the East and West Hart Dynasty,the generation and decline of Hart Dynasty Architecture show the development of thinking, from Confucianism to Daoism to combination of Daoism and Buddhist.it reflects the religious belief at that time and expresses r%两汉时期,汉画像从产生到衰落,展示了汉代从原始的本元化思维——神化儒家思想——道教神仙思想——佛道共存的淡泊的思想的发展历程,从一个侧面反映了汉代民间的宗教信仰,传达出追求永生、向往自由的浪漫思想。

  10. A multidisciplinary study using in vivo tumor models and microfluidic cell-on-chip approach to explore the cross-talk between cancer and immune cells.

    Science.gov (United States)

    Mattei, Fabrizio; Schiavoni, Giovanna; De Ninno, Adele; Lucarini, Valeria; Sestili, Paola; Sistigu, Antonella; Fragale, Alessandra; Sanchez, Massimo; Spada, Massimo; Gerardino, Annamaria; Belardelli, Filippo; Businaro, Luca; Gabriele, Lucia

    2014-10-01

    A full elucidation of events occurring inside the cancer microenvironment is fundamental for the optimization of more effective therapies. In the present study, the cross-talk between cancer and immune cells was examined by employing mice deficient (KO) in interferon regulatory factor (IRF)-8, a transcription factor essential for induction of competent immune responses. The in vivo results showed that IRF-8 KO mice were highly permissive to B16.F10 melanoma growth and metastasis due to failure of their immune cells to exert proper immunosurveillance. These events were found to be dependent on soluble factors released by cells of the immune system capable of shaping the malignant phenotype of melanoma cells. An on-chip model was then generated to further explore the reciprocal interactions between the B16.F10 and immune cells. B16.F10 and immune cells were co-cultured in a microfluidic device composed of three culturing chambers suitably inter-connected by an array of microchannels; mutual interactions were then followed using time-lapse microscopy. It was observed that WT immune cells migrated through the microchannels towards the B16.F10 cells, establishing tight interactions that in turn limited tumor spread. In contrast, IRF-8 KO immune cells poorly interacted with the melanoma cells, resulting in a more invasive behavior of the B16.F10 cells. These results suggest that IRF-8 expression plays a key role in the cross-talk between melanoma and immune cells, and under-score the value of cell-on-chip approaches as useful in vitro tools to reconstruct complex in vivo microenvironments on a microscale level to explore cell interactions such as those occurring within a cancer immunoenvironment.

  11. 建环专业传热学教学体会与探讨%On teaching consideration for Heat Transfer Theory of architectural environment major and its exploration

    Institute of Scientific and Technical Information of China (English)

    刘其鑫

    2011-01-01

    传热学是建筑环境与设备工程专业十分重要的专业基础理论课程,基于讲授建环专业《传热学》课程的体会,总结了传热学课程的特点以及在教学过程中发现的问题,针对这些问题,就如何调动学生学习积极性、平时上课内容、教学实验课内容设置等方面进行了简单的探讨,以达到预期的教学效果。%The paper indicates Heat Transfer Theory can be the important course of professional basic theory for the major of architectural environment and equipment engineering, sums up the features for the courses of Heat Transfer Theory and problems in the teaching process based on the consideration in the teaching of the course of Heai Transfer Theory for the major of architectural environment, and explores the ways of how to arouse students learning initiatives, how to design lessons and to allocate the teaching and experiment lessons, so as to achieve expected teaching effect.

  12. Architectural geometry

    KAUST Repository

    Pottmann, Helmut

    2014-11-26

    Around 2005 it became apparent in the geometry processing community that freeform architecture contains many problems of a geometric nature to be solved, and many opportunities for optimization which however require geometric understanding. This area of research, which has been called architectural geometry, meanwhile contains a great wealth of individual contributions which are relevant in various fields. For mathematicians, the relation to discrete differential geometry is significant, in particular the integrable system viewpoint. Besides, new application contexts have become available for quite some old-established concepts. Regarding graphics and geometry processing, architectural geometry yields interesting new questions but also new objects, e.g. replacing meshes by other combinatorial arrangements. Numerical optimization plays a major role but in itself would be powerless without geometric understanding. Summing up, architectural geometry has become a rewarding field of study. We here survey the main directions which have been pursued, we show real projects where geometric considerations have played a role, and we outline open problems which we think are significant for the future development of both theory and practice of architectural geometry.

  13. Multithreading architecture

    CERN Document Server

    Nemirovsky, Mario

    2013-01-01

    Multithreaded architectures now appear across the entire range of computing devices, from the highest-performing general purpose devices to low-end embedded processors. Multithreading enables a processor core to more effectively utilize its computational resources, as a stall in one thread need not cause execution resources to be idle. This enables the computer architect to maximize performance within area constraints, power constraints, or energy constraints. However, the architectural options for the processor designer or architect looking to implement multithreading are quite extensive and

  14. Architectural Anthropology

    DEFF Research Database (Denmark)

    Stender, Marie

    and other spaces that architects are preoccupied with. On the other hand, the distinction between architecture and design is not merely one of scale. Design and architecture represent – at least in Denmark – also quite different disciplinary traditions and methods. Where designers develop prototypes......, architects tend to work with models and plans that are not easily understood by lay people. Further, many architects are themselves sceptical towards notions of user-involvement and collaborative design. They fear that the imagination of citizens and users is restricted to what they are already familiar with...

  15. Exploration and realization of campus architecture energy conservation supervision system%校园建筑节能监管系统的探索与实现

    Institute of Scientific and Technical Information of China (English)

    黄志国

    2011-01-01

    In order to construct a saving campus and improve the efficiency of energy and water utilization and scientific management level. This paper introduces the campus architecture energy conservation supervision system and analyses the feasibility of the system based on hardware and software by illustrating the construction of energy conservation supervision system of Ningxia University. The system realizes the supervision and management of water, electric, gas and heating utilization of important energy utilization organizations and public facilities by the remote data acquisition unit, which bases on college network and low-voltage power carrier remote meter reading technique. By analysing energy-saving performance, the paper concludes that the built system will effectively improve the management level of water and energy utilization, and save energy and money for the university.%为了创建节约型校园,提高学校用能、用水效率和科学管理的水平,以宁夏大学节能监管系统项目建设为例,对校园建筑节能监管系统进行介绍,从硬件和软件上分析了节能监管系统的可行性,其监管系统主要是利用校园网和低压载波远程抄表技术,通过远端数据采集实现对重点能耗单位及公共设施的水、电、暖、气等的监控和管理.通过节能效益分析可知,该系统的建成将有力提升学校用能用水的管理水平,并能为学校降低能耗、节约资金.

  16. CITAstudio: Computation in Architecture 2015

    DEFF Research Database (Denmark)

    Nicholas, Paul; Ayres, Phil

    2016-01-01

    CITAstudio yearbook. CITAstudio: Computation in Architecture is a two year International Master's Programme at The Royal Danish Academy of Fine Arts, School of Architecture. With a focus on digital design and material fabrication the programme questions how computation is changing our spatial......, representational and material cultures. Through hands-on experimentation and production the programme emphasises learning-through-doing as a principle method for exploring computation as a means to pursue speculative design, experimental fabrication, material actuation and complex modelling....

  17. Architectural Tops

    Science.gov (United States)

    Mahoney, Ellen

    2010-01-01

    The development of the skyscraper is an American story that combines architectural history, economic power, and technological achievement. Each city in the United States can be identified by the profile of its buildings. The design of the tops of skyscrapers was the inspiration for the students in the author's high-school ceramic class to develop…

  18. Religious Architecture

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The main religions of ancient China were Buddhism,Taoism and Islam, of which Buddhism was the most widespread. As a result, Buddhist temples and towers are found all over China, and have become important components of the country's ancient architecture.

  19. Architectural Illusion.

    Science.gov (United States)

    Doornek, Richard R.

    1990-01-01

    Presents a lesson plan developed around the work of architectural muralist Richard Haas. Discusses the significance of mural painting and gives key concepts for the lesson. Lists class activities for the elementary and secondary grades. Provides a photograph of the Haas mural on the Fountainbleau Hilton Hotel, 1986. (GG)

  20. Textile Architecture

    DEFF Research Database (Denmark)

    Heimdal, Elisabeth Jacobsen

    2010-01-01

    Textiles can be used as building skins, adding new aesthetic and functional qualities to architecture. Just like we as humans can put on a coat, buildings can also get dressed. Depending on our mood, or on the weather, we can change coat, and so can the building. But the idea of using textiles...

  1. MUF architecture /art London

    DEFF Research Database (Denmark)

    Svenningsen Kajita, Heidi

    2009-01-01

    Om MUF architecture samt interview med Liza Fior og Katherine Clarke, partnere i muf architecture/art......Om MUF architecture samt interview med Liza Fior og Katherine Clarke, partnere i muf architecture/art...

  2. Architectural Exploration and Design of Time-Interleaved SAR Arrays for Low-Power and High Speed A/D Converters

    Science.gov (United States)

    Saponara, Sergio; Nuzzo, Pierluigi; Nani, Claudio; van der Plas, Geert; Fanucci, Luca

    Time-interleaved (TI) analog-to-digital converters (ADCs) are frequently advocated as a power-efficient solution to realize the high sampling rates required in single-chip transceivers for the emerging communication schemes: ultra-wideband, fast serial links, cognitive-radio and software-defined radio. However, the combined effects of multiple distortion sources due to channel mismatches (bandwidth, offset, gain and timing) severely affect system performance and power consumption of a TI ADC and need to be accounted for since the earlier design phases. In this paper, system-level design of TI ADCs is addressed through a platform-based methodology, enabling effective investigation of different speed/resolution scenarios as well as the impact of parallelism on accuracy, yield, sampling-rate, area and power consumption. Design space exploration of a TI successive approximation ADC is performed top-down via Monte Carlo simulations, by exploiting behavioral models built bottom-up after characterizing feasible implementations of the main building blocks in a 90-nm 1-V CMOS process. As a result, two implementations of the TI ADC are proposed that are capable to provide an outstanding figure-of-merit below 0.15pJ/conversion-step.

  3. Kosmos = architecture

    Directory of Open Access Journals (Sweden)

    Tine Kurent

    1985-12-01

    Full Text Available The old Greek word "kosmos" means not only "cosmos", but also "the beautiful order", "the way of building", "building", "scenography", "mankind", and, in the time of the New Testament, also "pagans". The word "arhitekton", meaning first the "master of theatrical scenography", acquired the meaning of "builder", when the words "kosmos" and ~kosmetes" became pejorative. The fear that architecture was not considered one of the arts before Renaissance, since none of the Muses supervised the art of building, results from the misunderstanding of the word "kosmos". Urania was the Goddes of the activity implied in the verb "kosmein", meaning "to put in the beautiful order" - everything, from the universe to the man-made space, i. e. the architecture.

  4. Bone tumor

    Science.gov (United States)

    Tumor - bone; Bone cancer; Primary bone tumor; Secondary bone tumor; Bone tumor - benign ... The cause of bone tumors is unknown. They often occur in areas of the bone that grow rapidly. Possible causes include: Genetic defects ...

  5. Architectural Theatricality

    DEFF Research Database (Denmark)

    Tvedebrink, Tenna Doktor Olsen

    putting an emphasis on architecture as unified scenery guided by the four motives hearth, enclosure, dressing and context. This theoretical framework draws on the Gastronomic Analogy put forth by James Fergusson in 1862 and an interpretation of the writings of the 19th century architect Gottfried Semper...... with the material appearance of objects, but also the imaginary world of dreams and memories which are concealed with the communicative significance of intentions when designing the future super hospitals....

  6. Architectural Theatricality

    DEFF Research Database (Denmark)

    Tvedebrink, Tenna Doktor Olsen; Fisker, Anna Marie; Kirkegaard, Poul Henning

    2013-01-01

    is known for his writings on theatricality, understood as a holistic design approach emphasizing the contextual, cultural, ritual and social meanings rooted in architecture. Relative hereto, the International Food Design Society recently argued, in a similar holistic manner, that the methodology used......’ is an overlooked element in hospital eating environments today, and further point at how Semper’s discourse on theatricality can be used to add a more nuanced perspective to future hospitality studies....

  7. Performative Urban Architecture

    DEFF Research Database (Denmark)

    Thomsen, Bo Stjerne; Jensen, Ole B.

    The paper explores how performative urban architecture can enhance community-making and public domain using socio-technical systems and digital technologies to constitute an urban reality. Digital medias developed for the web are now increasingly occupying the urban realm as a tool for navigating...... the perspectives of using interactive technologies for performative objects, which are able to register the impulses of urban activity and reproduce the contexts of the city. In this way the performative environment is established as an event setting providing an embodied experience as a ‘quasi-object' that can...... couple relationships between architecture, humans and society. These performative relationships between digital and physical environments are seen as illustrative of the social production of space by performance and the creative production of identity. The paper reflects on the perspectives...

  8. Aerobot Autonomy Architecture

    Science.gov (United States)

    Elfes, Alberto; Hall, Jeffery L.; Kulczycki, Eric A.; Cameron, Jonathan M.; Morfopoulos, Arin C.; Clouse, Daniel S.; Montgomery, James F.; Ansar, Adnan I.; Machuzak, Richard J.

    2009-01-01

    An architecture for autonomous operation of an aerobot (i.e., a robotic blimp) to be used in scientific exploration of planets and moons in the Solar system with an atmosphere (such as Titan and Venus) is undergoing development. This architecture is also applicable to autonomous airships that could be flown in the terrestrial atmosphere for scientific exploration, military reconnaissance and surveillance, and as radio-communication relay stations in disaster areas. The architecture was conceived to satisfy requirements to perform the following functions: a) Vehicle safing, that is, ensuring the integrity of the aerobot during its entire mission, including during extended communication blackouts. b) Accurate and robust autonomous flight control during operation in diverse modes, including launch, deployment of scientific instruments, long traverses, hovering or station-keeping, and maneuvers for touch-and-go surface sampling. c) Mapping and self-localization in the absence of a global positioning system. d) Advanced recognition of hazards and targets in conjunction with tracking of, and visual servoing toward, targets, all to enable the aerobot to detect and avoid atmospheric and topographic hazards and to identify, home in on, and hover over predefined terrain features or other targets of scientific interest. The architecture is an integrated combination of systems for accurate and robust vehicle and flight trajectory control; estimation of the state of the aerobot; perception-based detection and avoidance of hazards; monitoring of the integrity and functionality ("health") of the aerobot; reflexive safing actions; multi-modal localization and mapping; autonomous planning and execution of scientific observations; and long-range planning and monitoring of the mission of the aerobot. The prototype JPL aerobot (see figure) has been tested extensively in various areas in the California Mojave desert.

  9. THE DYNAMICS OF THE FORM OF NUSANTARA MOSQUE: ARCHITECTURAL HOMOGENEITY VIS A VIS ARCHITECTURAL HYBRIDITY

    Directory of Open Access Journals (Sweden)

    Pudji Pratitis Wismantara

    2012-09-01

    Full Text Available There are two points of departure in the design of mosque architecture in Nusantara, namely architectural homogeneity and architectural hybridity. Each provides the legitimacy of the architecture of identity formation. This paper seeks to explore the comparative, the concept of homogeneity and hybridity architecture, with a critical theory approach. The  results of this search is, the concept of architectural homogeneity establishing assumption that certain architectural forms are supposed to represent "universal identity and modernity" of Muslim architecture. Meanwhile, the concept of architectural hybridity to show enrichment architecture identity because of the attempt to combine aspects of the universality of Islam with locality of Nusantara. Both these aspects can be positioned as the two subjects of mutual dialogue in a parallel position. As architecture strategy, the concept of hybridity reflects the effort or ijtihad in interpreting local and universal contextuality in the contemporary conditions that are constantly evolving and open.Keywords: Nusantara mosque, hybridity of architecture, homogeneity of architecture, architecture strategy

  10. Materials Driven Architectural Design and Representation

    DEFF Research Database (Denmark)

    Kruse Aagaard, Anders

    2015-01-01

    another role in relation to architectural production. It is, in this paper, the intention to point at material research as an active initiator in explorative approaches to architectural design methods and architectural representation. This paper will point at the inclusion of tangible and experimental......This paper aims to outline a framework for a deeper connection between experimentally obtained material knowledge and architectural design. While materials and architecture in the process of realisation are tightly connected, architectural design and representation are often distanced from...... the material domain in which the construction eventually will happen. In many cases, it can seem that materials play the role of a selection of building blocks from which a determined architectural vision or representation are tried to be build. Research in materials, materials behaviour and new materials...

  11. From green architecture to architectural green

    DEFF Research Database (Denmark)

    Earon, Ofri

    2011-01-01

    they have overshadowed the architectural potential of green architecture. The paper questions how a green space should perform, look like and function. Two examples are chosen to demonstrate thorough integrations between green and space. The examples are public buildings categorized as pavilions. One....... Architectural green could signify green architecture with inclusive interrelations between green and space, built and unbuilt, inside and outside. The aim of the term is to reflect a new focus in green architecture – its architectural performance. Ecological issues are not underestimated or ignored, but so far......The paper investigates the topic of green architecture from an architectural point of view and not an energy point of view. The purpose of the paper is to establish a debate about the architectural language and spatial characteristics of green architecture. In this light, green becomes an adjective...

  12. The solid-state signaling pathway from extracellular matrix to nuclear matrix: The critical role of three-dimensional architecture for functional differentiation

    Energy Technology Data Exchange (ETDEWEB)

    Lelievre, S.; Bissell, M.J. [Lawrence Berkeley National Lab., CA (United States)

    1997-02-01

    Breast cells are useful experimental subjects for cell biologists because the mammary gland is one of the few tissues that undergoes dramatic changes in form and function after adulthood. Recently, the study in our laboratory of a human breast tumor progression series has allowed for the analysis of changes in cellular architecture (including nuclear architecture) when phenotypically normal cells become tumorigenic. This research aims to participate in the battle against breast cancer by helping to understand tumor progression and to identify new therapeutic markers for cancer treatment. This article explores the advantages and challenges of using high resolution X-ray computed microtomography for the study of 3-dimensional organization of breast tissue architecture.

  13. Space and Architecture's Current Line of Research? A Lunar Architecture Workshop With An Architectural Agenda.

    Science.gov (United States)

    Solomon, D.; van Dijk, A.

    The "2002 ESA Lunar Architecture Workshop" (June 3-16) ESTEC, Noordwijk, NL and V2_Lab, Rotterdam, NL) is the first-of-its-kind workshop for exploring the design of extra-terrestrial (infra) structures for human exploration of the Moon and Earth-like planets introducing 'architecture's current line of research', and adopting an architec- tural criteria. The workshop intends to inspire, engage and challenge 30-40 European masters students from the fields of aerospace engineering, civil engineering, archi- tecture, and art to design, validate and build models of (infra) structures for Lunar exploration. The workshop also aims to open up new physical and conceptual terrain for an architectural agenda within the field of space exploration. A sound introduc- tion to the issues, conditions, resources, technologies, and architectural strategies will initiate the workshop participants into the context of lunar architecture scenarios. In my paper and presentation about the development of the ideology behind this work- shop, I will comment on the following questions: * Can the contemporary architectural agenda offer solutions that affect the scope of space exploration? It certainly has had an impression on urbanization and colonization of previously sparsely populated parts of Earth. * Does the current line of research in architecture offer any useful strategies for com- bining scientific interests, commercial opportunity, and public space? What can be learned from 'state of the art' architecture that blends commercial and public pro- grammes within one location? * Should commercial 'colonisation' projects in space be required to provide public space in a location where all humans present are likely to be there in a commercial context? Is the wave in Koolhaas' new Prada flagship store just a gesture to public space, or does this new concept in architecture and shopping evolve the public space? * What can we learn about designing (infra-) structures on the Moon or any other

  14. Interest of the PET with 18-F.D.G. in the exploration of cardiac tumors. About one case; Interet de la TEP au 18-FDG dans l'exploration des tumeurs cardiaques. A propos d'un cas

    Energy Technology Data Exchange (ETDEWEB)

    Lussato, D.; Songy, B.; Penaud, D.; Karila Cohen, D.; Vigoni, F. [Centre cardiologique du Nord, Saint-Denis, (France)

    2009-05-15

    The positron computed tomography (PET) with {sup 18}F.D.G. is today a key examination in oncology, but its use in the exploration of cardiac tumors is not actually established. The PET enlightened a hyper-metabolic injury of the left auricle, reaching to the right pulmonary veins, associated to numerous hyper-metabolic centres: hepatic, osseous and muscular ones. A muscular adjusted biopsy enlightened a metastatic fibrosarcoma. An adapted neoplastic treatment was established. This observation illustrates the potential interest of the PET with {sup 18}F.D.G. in the diagnosis of malignancy of cardiac tumor injuries and their eventual extension evaluation. (N.C.)

  15. Textile Architecture

    DEFF Research Database (Denmark)

    Heimdal, Elisabeth Jacobsen

    2010-01-01

    Textiles can be used as building skins, adding new aesthetic and functional qualities to architecture. Just like we as humans can put on a coat, buildings can also get dressed. Depending on our mood, or on the weather, we can change coat, and so can the building. But the idea of using textiles...... to create human habitation is not new. As Diether S. Hope phrases it, referring to tents: The history of development of humanity would be barely conceivable without free spanning textile membrane structures....

  16. Catalyst Architecture

    DEFF Research Database (Denmark)

    Kiib, Hans; Marling, Gitte; Hansen, Peter Mandal

    2014-01-01

    of programs, have a role in mediating positive social and/or cultural development. In this sense, we talk about architecture as a catalyst for: sustainable adaptation of the city’s infrastructure appropriate renovation of dilapidated urban districts strengthening of social cohesiveness in the city development...... meaningful for everyone. The exhibited works are designed by SANAA, Diller Scofidio + Renfro, James Corner Field Operation, JBMC Arquitetura e Urbanismo, Atelier Bow-Wow, Ateliers Jean Nouvel, COBE, Transform, BIG, Topotek1, Superflex, and by visual artist Jane Maria Petersen....

  17. Architectural dreaming

    Institute of Scientific and Technical Information of China (English)

    Mark Godfrey

    2004-01-01

    <正> For the first 800 years of its existence, Beijing retained essentially the same character: a walled palace city at its centre, organised on a strict north-south axis and contained within a sea of courtyard houses along lanes too narrow forcars. Today Beijing’s basic unit of architectural scale has become the skyscraper, erected a dozen at a time and facing massive highways. Ancient buildings are so small and unloved by comparison that they threaten to disappear from view. Fuelled by an economic boom, and propelled by banks flushed with mortgage cash, Beijing has embarked on the largest building campaign the world has ever seen.

  18. Etruscan Divination and Architecture

    Science.gov (United States)

    Magli, Giulio

    The Etruscan religion was characterized by divination methods, aimed at interpreting the will of the gods. These methods were revealed by the gods themselves and written in the books of the Etrusca Disciplina. The books are lost, but parts of them are preserved in the accounts of later Latin sources. According to such traditions divination was tightly connected with the Etruscan cosmovision of a Pantheon distributed in equally spaced, specific sectors of the celestial realm. We explore here the possible reflections of such issues in the Etruscan architectural remains.

  19. An empirical investigation of architectural prototyping

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Hansen, Klaus Marius

    2010-01-01

    Architectural prototyping is the process of using executable code to investigate stakeholders’ software architecture concerns with respect to a system under development. Previous work has established this as a useful and cost-effective way of exploration and learning of the design space of a syst...

  20. Assessment Methods and Tools for Architectural Curricula

    Science.gov (United States)

    Marriott, Christine A.

    2012-01-01

    This research explores the process of assessment within the arena of architectural education by questioning traditional assessment practices and probing into the conditions that necessitate change. As architectural educators we have opened our studios to digital technologies for the purposes of design and representation, but how do we measure and…

  1. Endolymphatic sac tumor : a rare cerebellopontine angle tumor.

    Directory of Open Access Journals (Sweden)

    Joseph B

    2002-10-01

    Full Text Available Endolymphatic sac tumors (ELST are rare papillary tumors of the temporal bone. Previously named as aggressive papillary middle ear tumors, they have recently been shown to arise from the endolymphatic sac. They are a rare in cerebello-pontine angle (CPA. We present a case of an ELST who presented as a CPA tumor with hydrocephalus. He underwent a ventriculo-peritoneal shunt initially. On exploration of the CP angle, the tumor was found to be extremely vascular. He was re-explored following embolization, and a subtotal excision of the tumor was done. Extensive petrous bone infiltration and vascularity of the tumor makes total excision almost impossible with high risk of cranial nerve deficits, excessive blood loss and CSF leak. This tumor should be considered in the differential diagnosis of vascular CPA tumors which erode the petrous temporal bone. The relevant literature is reviewed.

  2. Lab architecture

    Science.gov (United States)

    Crease, Robert P.

    2008-04-01

    There are few more dramatic illustrations of the vicissitudes of laboratory architecturethan the contrast between Building 20 at the Massachusetts Institute of Technology (MIT) and its replacement, the Ray and Maria Stata Center. Building 20 was built hurriedly in 1943 as temporary housing for MIT's famous Rad Lab, the site of wartime radar research, and it remained a productive laboratory space for over half a century. A decade ago it was demolished to make way for the Stata Center, an architecturally striking building designed by Frank Gehry to house MIT's computer science and artificial intelligence labs (above). But in 2004 - just two years after the Stata Center officially opened - the building was criticized for being unsuitable for research and became the subject of still ongoing lawsuits alleging design and construction failures.

  3. Multi-Robot Planetary Exploration Architectures Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Space policy direction is shifting, particularly with respect to human goals. Given the uncertainty of future missions to the moon, Mars, and other bodies, a tool...

  4. Exploration on Effect and Mechanism of Suiqing Pill (髓清丸) on Tumor Angiogenesis in Nude Mouse B16 Melanoma Model

    Institute of Scientific and Technical Information of China (English)

    杨振江; 赵霞; 邹映珍; 冯玉丽; 戴玲

    2004-01-01

    Objective: To study the effect of Suiqing Pill (SQP, 髓清丸), a TCM compound drug that can activate blood circulation and get rid of blood stasis, on angiogenesis in tumor and its possible mechanism.Method: BALB/c nude mice were inoculated with melanoma cell line R16 at right armpit subcutaneously to establish cancer spontaneous metastasis model. Levels of microvessel density (MVD), vascular endothelial growth factor (VEGF) and protein expression of matrix metalloproteinase-2 (MMP-2) in tumor tissues were observed and compared. Results: Strong expression of anti-Factor Ⅷ (FⅧ) related antigen and plentiful tumor angiogenesis were seen in model control animals, while in the high-dose and low-dose SQP treated model mice, MVD was inhibited by 33.5 % and 22.6 % respectively ( P<0.01, P<0.05). The strong positive protein expression of VEGF and MMP-2 in model control also reduced in the SQP treated groups. Conclusion: SQP could inhibit tumor angiogenesis, protein expression of VEGF and MMP-2 in nude mice B16 melanoma models.

  5. Decoding the architectural theory

    Institute of Scientific and Technical Information of China (English)

    Gu Mengchao

    2008-01-01

    Starting from the illustration of the definition and concept of the architectural theory, the author established his unique understanding about the framework of the architectural theory and the innovation of the architectural theory underlined by Chinese characteristics.

  6. SUSTAINABLE ARCHITECTURE : WHAT ARCHITECTURE STUDENTS THINK

    OpenAIRE

    SATWIKO, PRASASTO

    2013-01-01

    Sustainable architecture has become a hot issue lately as the impacts of climate change become more intense. Architecture educations have responded by integrating knowledge of sustainable design in their curriculum. However, in the real life, new buildings keep coming with designs that completely ignore sustainable principles. This paper discusses the results of two national competitions on sustainable architecture targeted for architecture students (conducted in 2012 and 2013). The results a...

  7. Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment

    Directory of Open Access Journals (Sweden)

    Jaehong Kim

    2016-01-01

    Full Text Available Distinct tumor microenvironment forms in each progression step of cancer and has diverse capacities to induce both adverse and beneficial consequences for tumorigenesis. It is now known that immune cells can be activated to favor tumor growth and progression, most probably influenced by the tumor microenvironment. Tumor-associated macrophages and tumor-associated neutrophils can exert protumoral functions, enhancing tumor cell invasion and metastasis, angiogenesis, and extracellular matrix remodeling, while inhibiting the antitumoral immune surveillance. Considering that neutrophils in inflammatory environments recruit macrophages and that recruited macrophages affect neutrophil functions, there may be various degrees of interaction between tumor-associated macrophages and tumor-associated neutrophils. Platelets also play an important role in the recruitment and regulation of monocytic and granulocytic cells in the tumor tissues, suggesting that platelet function may be essential for generation of tumor-associated macrophages and tumor-associated neutrophils. In this review, we will explore the biology of tumor-associated macrophages and tumor-associated neutrophils and their possible interactions in the tumor microenvironment. Special attention will be given to the recruitment and activation of these tumor-associated cells and to the roles they play in maintenance of the tumor microenvironment and progression of tumors.

  8. Modeling Architectural Patterns Using Architectural Primitives

    NARCIS (Netherlands)

    Zdun, Uwe; Avgeriou, Paris

    2005-01-01

    Architectural patterns are a key point in architectural documentation. Regrettably, there is poor support for modeling architectural patterns, because the pattern elements are not directly matched by elements in modeling languages, and, at the same time, patterns support an inherent variability that

  9. Lightweight enterprise architectures

    CERN Document Server

    Theuerkorn, Fenix

    2004-01-01

    STATE OF ARCHITECTUREArchitectural ChaosRelation of Technology and Architecture The Many Faces of Architecture The Scope of Enterprise Architecture The Need for Enterprise ArchitectureThe History of Architecture The Current Environment Standardization Barriers The Need for Lightweight Architecture in the EnterpriseThe Cost of TechnologyThe Benefits of Enterprise Architecture The Domains of Architecture The Gap between Business and ITWhere Does LEA Fit? LEA's FrameworkFrameworks, Methodologies, and Approaches The Framework of LEATypes of Methodologies Types of ApproachesActual System Environmen

  10. Software architecture 2

    CERN Document Server

    Oussalah, Mourad Chabanne

    2014-01-01

    Over the past 20 years, software architectures have significantly contributed to the development of complex and distributed systems. Nowadays, it is recognized that one of the critical problems in the design and development of any complex software system is its architecture, i.e. the organization of its architectural elements. Software Architecture presents the software architecture paradigms based on objects, components, services and models, as well as the various architectural techniques and methods, the analysis of architectural qualities, models of representation of architectural templa

  11. Software architecture 1

    CERN Document Server

    Oussalah , Mourad Chabane

    2014-01-01

    Over the past 20 years, software architectures have significantly contributed to the development of complex and distributed systems. Nowadays, it is recognized that one of the critical problems in the design and development of any complex software system is its architecture, i.e. the organization of its architectural elements. Software Architecture presents the software architecture paradigms based on objects, components, services and models, as well as the various architectural techniques and methods, the analysis of architectural qualities, models of representation of architectural template

  12. India emerging: New financial architecture

    Directory of Open Access Journals (Sweden)

    Sankarshan Basu

    2016-09-01

    Full Text Available The global financial crisis of 2007–2008 highlighted the need to re-evaluate several well established tenets in the world of finance. Questions have been raised the world over about the existing paradigm, leading to an acceptance that new financial architecture needed to be evolved and that new models need to emerge, keeping in mind the multiplicity of socio-economic realities that exist round the globe. In this context, the imperative for a new financial architecture in India is quite evident, and the ensuing panel discussion throws up some India-specific issues that need to be explored by the various stakeholders involved in this attempt.

  13. Computer organization, design, and architecture

    CERN Document Server

    Shiva, Sajjan G

    2007-01-01

    Suitable for a one- or two-semester undergraduate or beginning graduate course in computer science and computer engineering, Computer Organization, Design, and Architecture, Fourth Edition presents the operating principles, capabilities, and limitations of digital computers to enable development of complex yet efficient systems. With 40% updated material and four new chapters, this edition takes students through a solid, up-to-date exploration of single- and multiple-processor systems, embedded architectures, and performance evaluation. New to the Fourth Edition Additional material that cove

  14. The Practical Exploration of Multi-disciplinary Therapy System on Tumors%肿瘤多学科会诊制度的实践探讨

    Institute of Scientific and Technical Information of China (English)

    何毅刚; 孙延荣

    2014-01-01

    肿瘤的发病率在我国呈明显上升趋势,但在肿瘤治疗中还存在随意性、不规范性和重技术、轻服务,重数据、轻感受的现象。“多学科综合治疗”(MDT)已成为国外肿瘤治疗的主流趋势,在国内,也已经有少数医院开始尝试这样一种治疗模式,但要成功运转并不容易。国家卫生部开展的三级甲等医院评审中,将肿瘤多学科诊疗作为评审的核心指标,可见肿瘤规范性治疗的重要性和迫切性。因此,推行肿瘤多学科会诊制度,强化临床路径管理,规范肿瘤标准治疗具有重要意义。%The incidence of tumors in China increased significantly while, as to the treatment of tumor, it was arbitrariness, non-normative and focused on technology rather than service, focused on data rather than patients' feelings. Multidisciplinary therapy (MDT) has become a mainstream trend for cancer treatment abroad. In China, a few hospitals try to adopt MDT, but to operate successfully is not easy. During national hospital accreditation, the adoption of multi-disciplinary therapy was viewed as core indicators, which shows the importance and urgency of standardized treatment of tumors. Therefore, the implementation of the MDT, strengthening the clinical path management and standardizing cancer treatment is important to the treatment of tumor.

  15. Exploration architecturale pour la conception d'un système sur puce de vision robotique, adéquation algorithme-architecture d'un système embarqué temps-réel

    OpenAIRE

    Lefebvre, Thomas

    2012-01-01

    This Ph.D Thesis stands at the crossroads of three scientific domains : algorithm-architecture adequacy, bio-inspired vision systems in mobile robotics, and image processing.The goal is to make a robot autonomous in its visual perception, by the integration to the robot of this cognitive task, usually executed on remote processing servers.To achieve this goal, the design approach follows a path of algorithm architecture adequacy, where the different image processing steps of the vision system...

  16. Building Structure Design as an Integral Part of Architecture: A Teaching Model for Students of Architecture

    Science.gov (United States)

    Unay, Ali Ihsan; Ozmen, Cengiz

    2006-01-01

    This paper explores the place of structural design within undergraduate architectural education. The role and format of lecture-based structure courses within an education system, organized around the architectural design studio is discussed with its most prominent problems and proposed solutions. The fundamental concept of the current teaching…

  17. Can You Hear Architecture

    DEFF Research Database (Denmark)

    Ryhl, Camilla

    2016-01-01

    Taking an off set in the understanding of architectural quality being based on multisensory architecture, the paper aims to discuss the current acoustic discourse in inclusive design and its implications to the integration of inclusive design in architectural discourse and practice as well...... design and architectural quality for people with a hearing disability and a newly conducted qualitative evaluation research in Denmark as well as architectural theories on multisensory aspects of architectural experiences, the paper uses examples of existing Nordic building cases to discuss the role...... of acoustics in both inclusive design and multisensory architecture....

  18. To Explore the Cell Targeting Tumor Targeting Drug Carrier%探究肿瘤靶向物载体的细胞靶向性

    Institute of Scientific and Technical Information of China (English)

    胡俊

    2016-01-01

    Objective To investigate and analyze the cell targeting of tumor targeting vector. Methods Source selection to 293T cells and H460 cells as experimental samples, experimental sites were selected in the laboratory of our hospital for February 2016 to 2016 March, SP5 52, doxorubicin, the 4th generation of polyamide amine, ultra filtration centrifuge tube, fluorescence isothiocyanate fluorescein, and summarize and discuss the tumor target to drugs with cell targeting. Results U-under the conditions of conventional pharmaceutical formulations against tumor new drug target to support system develop-ment, and improve the drug in the carrier of metabolic dynamics characteristics, can make the drug to enriched to drug site of tumors and tumor cells aggregation, ensure curative effect to improve, toxic side effect decreases gradually, detection con-centration range cell survival rate of over 80%, which G4 - Ac toxicity is 90%, G4 - Ac - FITC as 87%, and G4 - Ac -FITC -SP5 52 cytotoxicity was 97%;the difference is statistically significant(P<0.05). Conclusion Under the influence of the continuous development of science and technology and progress, form of anticancer drugs work started towards the tar-get, efficient, intelligent direction, ideal of pharmaceutical dosage forms with controlled and sustained release, targeted de-velopment prospect is broad, it is in;clinical application of use and promotion.%目的:探讨和分析肿瘤靶向物载体的细胞靶向性。方法选择293T细胞和H460细胞作为实验标本,实验地点选择该院实验室,时间为2016年2—3月,选择合成的SP5-52、阿霉素、第4代聚酰胺—胺、超滤离心管、荧光分子异硫氰酸荧光素等,并总结和探讨肿瘤靶向性药物所具有的细胞靶向性。结果在常规药物制剂的条件下对抗肿瘤药物新型靶向载体系统进行发展,并且改善药物在载体内部的代谢动力学相关特征,能够让药物向富集到肿瘤药部位、

  19. Functional Biomimetic Architectures

    Science.gov (United States)

    Levine, Paul M.

    N-substituted glycine oligomers, or 'peptoids,' are a class of sequence--specific foldamers composed of tertiary amide linkages, engendering proteolytic stability and enhanced cellular permeability. Peptoids are notable for their facile synthesis, sequence diversity, and ability to fold into distinct secondary structures. In an effort to establish new functional peptoid architectures, we utilize the copper-catalyzed azide-alkyne [3+2] cycloaddition (CuAAC) reaction to generate peptidomimetic assemblies bearing bioactive ligands that specifically target and modulate Androgen Receptor (AR) activity, a major therapeutic target for prostate cancer. Additionally, we explore chemical ligation protocols to generate semi-synthetic hybrid biomacromolecules capable of exhibiting novel structures and functions not accessible to fully biosynthesized proteins.

  20. Naval open systems architecture

    Science.gov (United States)

    Guertin, Nick; Womble, Brian; Haskell, Virginia

    2013-05-01

    For the past 8 years, the Navy has been working on transforming the acquisition practices of the Navy and Marine Corps toward Open Systems Architectures to open up our business, gain competitive advantage, improve warfighter performance, speed innovation to the fleet and deliver superior capability to the warfighter within a shrinking budget1. Why should Industry care? They should care because we in Government want the best Industry has to offer. Industry is in the business of pushing technology to greater and greater capabilities through innovation. Examples of innovations are on full display at this conference, such as exploring the impact of difficult environmental conditions on technical performance. Industry is creating the tools which will continue to give the Navy and Marine Corps important tactical advantages over our adversaries.

  1. Application of combined laparoscopic peritoneal exploration and tumor markers in diagnosis of unknown origin aseites%腹腔镜联合肿瘤标记物检测在诊治疑难性腹水中的应用

    Institute of Scientific and Technical Information of China (English)

    孙敏; 李恒; 黄东

    2013-01-01

    Objective;To assess the value of combined laparoscopic peritoneal exploration and tumor markers in diagnosing unknown origin ascites. Methods: Retrospective analysis of ihe etiological factor of 86 cases were identified by laparoscopic abdomimal exploration and biopsy from May 2006 to September 2011. Diagnose accordance rate of different routine examinations, tumor marker in ascites between tuberculous peritonitis and abdominal extensive meta-slatic carcinoma, the serum tumor markers concentrations of the first test and after 6 months treatment, were compared. Results; The etiological factor of 82 cases were identified by laparoscopic exploration and biopsy,there were 35 cases of tuberculous peritonitis and 30 cases of metastatic carcinoma. There was no difference in diagnosis rate among different routine conventional in aging examinations ( P >0. 05). There was no significant difference of ascitic CEA, CA199,CA242 concentrations between tuberculous peritonitis and abdominal extensive metastatic carcinoma ( P > 0. 05 ) . The ascitic CA125 of abdominal extensive metastatic carcinoma was more than of tuberculous peritonitis ( P < 0. 05 ) . There was significant difference of serums marker CA125 between the patients with tuberculous peritonitis after 6 months treatment and their first serum test on admission(P <0.05). Conclusion; Combined laparoscopic peritoneal exploration and tumor markers in diagnosing unknown origin ascites was efficient. The ascitic CA125 of abdominal extensive metastatic carcinoma was more than of tuberculous peritonitis. Serum tumor marker CA125 can be used as performance monitor in the patients with tuberculous peritonitis and indicator of therapeutic effect.%目的:探讨腹腔镜联合肿瘤标记物检测用于诊治疑难性腹水的价值.方法:回顾性分析2006年5月至2011年9月86例疑难性腹水患者行腹腔镜探查活检术和肿瘤标记物的临床资料.就常规检查的诊断符合率和腹水肿瘤标记物在结核

  2. Building Strategic Capabilities for Sustained Lunar Exploration

    Science.gov (United States)

    Landgraf, M.; Hufenbach, B.; Houdou, B.

    2016-11-01

    We discuss a lunar exploration architecture that addresses the strategic objective of providing access to the lunar surface. This access enables the most exciting part of the lunar exploration: building a sustained infrastructure on the lunar surface.

  3. Sustainable, Reliable Mission-Systems Architecture

    Science.gov (United States)

    O'Neil, Graham; Orr, James K.; Watson, Steve

    2007-01-01

    A mission-systems architecture, based on a highly modular infrastructure utilizing: open-standards hardware and software interfaces as the enabling technology is essential for affordable and sustainable space exploration programs. This mission-systems architecture requires (a) robust communication between heterogeneous system, (b) high reliability, (c) minimal mission-to-mission reconfiguration, (d) affordable development, system integration, and verification of systems, and (e) minimal sustaining engineering. This paper proposes such an architecture. Lessons learned from the Space Shuttle program and Earthbound complex engineered system are applied to define the model. Technology projections reaching out 5 years are mde to refine model details.

  4. 镜下冷冻术治疗气道肿瘤护理工作探讨%To Explore the Nursing of Airway Tumor Cryotherapy Treatment Under Microscope

    Institute of Scientific and Technical Information of China (English)

    林婉萍

    2015-01-01

    无论是位于气管还是支气管处的肿瘤都是比较难以处理的,但是随着科学的发展,人们研究出了使用电子支气管镜下冷冻治疗的方法用来治疗气道肿瘤.治疗过程固然重要,但是是否能够康复痊愈关键还要看对患者的护理水平.不论是术前、术中还是术后的护理都是至关重要的.通过对近几年来的36例气道肿瘤患者在镜下(包括电刀和氩气刀)治疗的护理措施,探讨在不同情境下的护理,以使得患者在治疗后减轻呼吸困难的症状,提高生存质量.%Whether in trachea or bronchus tumors are more difficult to deal with, but with the development of science, people have developed a method using electronic bronchoscopic cryotherapy for treatment of airway tumor. The treatment process is important, but whether it can recover the key depends on the level of rehabilitation nursing of patients. Whether the nursing before operation, during operation and after operation is very important. According to the recent years 36 cases of patients with airway tumor under the microscope (including electric knife and argon knife) nursing treatment, to explore the nursing in different situations, to enable patients to reduce the symptoms of dyspnea after treatment, improve the quality of life.

  5. 大数据时代风景园林专业教学实践探索研究%Landscape Architecture Specialty Teaching Practice Exploration And Research In The Big Data Era

    Institute of Scientific and Technical Information of China (English)

    邬秀杰; 周曦

    2016-01-01

    Aiming at the existing problems at present about teaching of landscape architecture and the new requirements for the landscape architecture talents because of the big data era, based on personalized training, innovative thinking and angle of expanding the field, to discuss the teaching practice of strain path for landscape architecture discipline in the big data era. Explaining the level of integration between the landscape architecture discipline and big data, proposed innovations in curriculum setting, equipped with teachers, the method of teaching in the era of big data of reform measures.%针对当前风景园林专业教学中存在的问题以及大数据时代对风景园林人才培养提出的新要求,基于个性化能力培养和创新思维的角度,探讨大数据时代风景园林学科教学实践的应变路径。阐述了风景园林学科与大数据之间的融合程度,提出在创新课程设置、师资队伍配备、教学方法等方面在大数据时代的改革措施。

  6. 在当前中国城市建筑乱象下探索真正“建筑意”的表达%To Explore The Expression Of "Architectural Conception" In Today's China City Building Under The Mess

    Institute of Scientific and Technical Information of China (English)

    巩玉发; 曹志昌

    2016-01-01

    There are many of today's China city can not be overlooked chaos in the field of architectural design elaborated .So as a starting point of the problem,Fusion of modern western philosophy of architecture and construction techniques (Le Corbusier's machine aesthetics were represented) were researched and analyzed.In order to excavate some accordant "Architectural Conception" expressions which can realy mitigate these phenomena in modern Chinese architectural design.%对当前中国城市存在着的许多不容小视的建筑设计领域的乱象进行了深刻的阐述,并以此为问题的出发点,融合现代西方的建筑哲学和建筑技艺(以勒·柯布西耶的机器美学为代表)并对其进行了学习和思考,探索出几点符合现代中国建筑设计中能真正缓解这些乱象的“建筑意”的表达。

  7. Exporting Humanist Architecture

    DEFF Research Database (Denmark)

    Nielsen, Tom

    2016-01-01

    values and ethical stands involved in the export of Danish Architecture. Abstract: Danish architecture has, in a sense, been driven by an unwritten contract between the architects and the democratic state and its institutions. This contract may be viewed as an ethos – an architectural tradition...... with inherent aesthetic and moral values. Today, however, Danish architecture is also an export commodity. That raises questions, which should be debated as openly as possible. What does it mean for architecture and architects to practice in cultures and under political systems that do not use architecture...... as a way of generating humanism, freedom or equality? The essay outlines the background story, identifies a number of positions in relation to architecture exports and discusses some of the dilemmas that arise when Danish architecture is seen in an export perspective....

  8. Religious architecture: anthropological perspectives

    NARCIS (Netherlands)

    O. Verkaaik

    2013-01-01

    Religious Architecture: Anthropological Perspectives develops an anthropological perspective on modern religious architecture, including mosques, churches and synagogues. Borrowing from a range of theoretical perspectives on space-making and material religion, this volume looks at how religious buil

  9. Rhein-Ruhr architecture

    DEFF Research Database (Denmark)

    2002-01-01

    katalog til udstillingen 'Rhein - Ruhr architecture' Meldahls smedie, 15. marts - 28. april 2002. 99 sider......katalog til udstillingen 'Rhein - Ruhr architecture' Meldahls smedie, 15. marts - 28. april 2002. 99 sider...

  10. Planetary cubesats - mission architectures

    Science.gov (United States)

    Bousquet, Pierre W.; Ulamec, Stephan; Jaumann, Ralf; Vane, Gregg; Baker, John; Clark, Pamela; Komarek, Tomas; Lebreton, Jean-Pierre; Yano, Hajime

    2016-07-01

    Miniaturisation of technologies over the last decade has made cubesats a valid solution for deep space missions. For example, a spectacular set 13 cubesats will be delivered in 2018 to a high lunar orbit within the frame of SLS' first flight, referred to as Exploration Mission-1 (EM-1). Each of them will perform autonomously valuable scientific or technological investigations. Other situations are encountered, such as the auxiliary landers / rovers and autonomous camera that will be carried in 2018 to asteroid 1993 JU3 by JAXA's Hayabusas 2 probe, and will provide complementary scientific return to their mothership. In this case, cubesats depend on a larger spacecraft for deployment and other resources, such as telecommunication relay or propulsion. For both situations, we will describe in this paper how cubesats can be used as remote observatories (such as NEO detection missions), as technology demonstrators, and how they can perform or contribute to all steps in the Deep Space exploration sequence: Measurements during Deep Space cruise, Body Fly-bies, Body Orbiters, Atmospheric probes (Jupiter probe, Venus atmospheric probes, ..), Static Landers, Mobile landers (such as balloons, wheeled rovers, small body rovers, drones, penetrators, floating devices, …), Sample Return. We will elaborate on mission architectures for the most promising concepts where cubesat size devices offer an advantage in terms of affordability, feasibility, and increase of scientific return.

  11. Architectural Knitted Surfaces

    DEFF Research Database (Denmark)

    Mossé, Aurélie

    2010-01-01

    WGSN reports from the Architectural Knitted Surfaces workshop recently held at ShenkarCollege of Engineering and Design, Tel Aviv, which offered a cutting-edge insight into interactive knitted surfaces. With the increasing role of smart textiles in architecture, the Architectural Knitted Surfaces...

  12. Sustainable architecture (green architecture and its role in urban sustainable development (architecture

    Directory of Open Access Journals (Sweden)

    Yousefi, Mohammad

    2016-03-01

    Full Text Available "Sustainable development" proposed for dealing with problems of development after world war which was merely economic. Regard to the future generations, environment and conservation of the global environment, idealism in new methods and reducing the losses arising from constructions in the cities and consequently achieving a sustainable designing pattern have been the main focus of all sustainable development definitions. In fact, sustainable development is an ecologic concept that unlike the economic views which know the nature as a self-centered set which satisfies the humans, needs, sees nature a set of an ecosystem that human is also a part of it. The studies indicate that if in architectural constructions of a city, the sustainable architecture principles are observed correctly, it will be a big step for the sustainability of the city. In other words, green architecture is arising from urban sustainable development which is also arising from today' s human need in confronting with unpleasant consequences of industrial and consumptive world of current era. Obviously, achieving sustainable cities needs infrastructures which are scrutinized and explained in green development approach. This article with descriptive method in order to explore the green consumptions and its benefits in improving the life quality of human and constructive role of green architecture in the route of urban sustainable development according to the mentioned studies and evidences concludes about achieving the principles of urban sustainable development.

  13. Explore the Similarity of Mies Van Der Rohe and Chinese Traditional Architecture%探寻密斯•凡•德罗与中国传统建筑之同

    Institute of Scientific and Technical Information of China (English)

    鲍丽丽

    2013-01-01

      本文从建筑理念、空间、布局、结构与材料等方面去探讨密斯的建筑作品与中国传统建筑的相似性。对如何通过改变建造体系、使中国传统建筑适应现代功能需求,提供借鉴参考。%This article is to compare Meis van der Rohe’ wor-ks with Chinese traditional architecture. With the comparative study of idea,space,plan,structure and material,it is aimed at finding the connecting link between them and thinking how to make Chinese traditional architecture fit modern life by cha-nging its construction system.

  14. The Exploration on the Feng Shuey Philosophy of Parametric Architectural Design%探究参数化建筑设计中所蕴藏的风水哲理

    Institute of Scientific and Technical Information of China (English)

    张硕; 王丽

    2014-01-01

    Author studies on feng shuey philosophy of para-metric architectural design, taking galaxy SOHO and CCTV new building as examples to il ustrate that the feng shuey cu-lture which has been passed down for thousand years must have it’s value of spread and that parametric architectural also wil be dif icult to get the inheritance of history out of the feng shuey philosophy.%笔者就参数化建筑中所蕴藏的风水哲理进行探讨,以银河SOHO和央视新大楼为例意在阐明在中国流传了千年之久的风水文化必有其传播价值,并且脱离了风水的参数化建筑也将很难得到历史的传承。

  15. Hypothalamic tumor

    Science.gov (United States)

    Complications of brain surgery may include: Bleeding Brain damage Death (rarely) Infection Seizures can result from the tumor or from any surgical procedure on the brain. Hydrocephalus can occur with some tumors and ...

  16. Wilms Tumor

    Science.gov (United States)

    ... Wilms tumor is 1 pound at diagnosis. Some children also may have nausea, stomach pain, high blood pressure (hypertension), blood in the urine, loss of appetite, or fever. Even though Wilms tumors often are ...

  17. “两院一体化”模式下建筑学研究生培养探索%Exploration of postgraduate cultivation in architectural discipline under the mode of “integration of school and institute”

    Institute of Scientific and Technical Information of China (English)

    孙澄; 邢凯; 陆诗亮

    2016-01-01

    There are some problems on the unbalance between attaching importance to theoretical study and neglecting specialty practice in postgraduate training of professional degree in architecture. This paper introduces the reform of graduate cultivating mode of architecture under the mode of “integration of school and institute” in School of Architecture, Harbin Institute of Technology. That is starting with innovation of the cultivating mode, which adds courses such as open design and special subject of architecture to curriculum, improves practice part with joint design studio, joint scientific and other works. Meanwhile, it also solves the problems including sluggish nurturing aim, weak curriculum setting, formalized practice process and etc.%目前,建筑学专业学位研究生培养中还存在偏重理论学习而忽视专业实践的问题。文章介绍了哈尔滨工业大学建筑学院“两院一体化”办学模式下的建筑学专业研究生培养模式,即从培养模式的创新入手,通过在课程体系中增设建筑设计专题与开放设计等课程,在实践环节上采取联合设计与联合科研等措施,解决校企联合培养中培养目标滞后,课程设置指向性不强,以及实践环节流于形式等问题。

  18. Exploration architecturale pour la conception d'un système sur puce de vision robotique, adéquation algorithme-architecture d'un système embarqué temps-réel

    OpenAIRE

    Lefebvre, Thomas

    2012-01-01

    This Ph.D Thesis stands at the crossroads of three scientific domains : algorithmarchitecture adequacy, bio-inspired vision systems in mobile robotics, and image processing. The goal is to make a robot autonomous in its visual perception, by the integration to the robot of this cognitive task, usually executed on remote processing servers. To achieve this goal, the design approach follows a path of algorithm architecture adequacy, where the different image processing steps of the vision syste...

  19. Software architecture evolution

    DEFF Research Database (Denmark)

    Barais, Olivier; Le Meur, Anne-Francoise; Duchien, Laurence

    2008-01-01

    Software architectures must frequently evolve to cope with changing requirements, and this evolution often implies integrating new concerns. Unfortunately, when the new concerns are crosscutting, existing architecture description languages provide little or no support for this kind of evolution....... The software architect must modify multiple elements of the architecture manually, which risks introducing inconsistencies. This chapter provides an overview, comparison and detailed treatment of the various state-of-the-art approaches to describing and evolving software architectures. Furthermore, we discuss...... one particular framework named Tran SAT, which addresses the above problems of software architecture evolution. Tran SAT provides a new element in the software architecture descriptions language, called an architectural aspect, for describing new concerns and their integration into an existing...

  20. Breathing architecture: Conceptual architectural design based on the investigation into the natural ventilation of buildings

    Directory of Open Access Journals (Sweden)

    Anastasia D. Stavridou

    2015-06-01

    Full Text Available This study explores architectural design by examining air, fluid mechanics, and the natural ventilation of buildings. In this context, this research introduces a new way of dealing with the process of architectural synthesis. The proposed way can be used either to create new architectural projects or to rethink existing ones. This study is supported by previous investigation into the natural ventilation of buildings via computational and laboratory simulation (Stavridou, 2011; Stavridou and Prinos, 2013. The investigation into the natural ventilation of buildings provides information and data that affect architectural design through various parameters. The parameters of architectural synthesis that are influenced and discussed in this paper are the following: (i inspiration and analogical transfer, (ii initial conception of the main idea using computational fluid dynamics (digital design, (iii development of the main idea through an investigatory process toward building form optimization, and (iv form configuration, shape investigation, and other morphogenetic prospects. This study illustrates the effect of natural ventilation research on architectural design and thus produces a new approach to the architectural design process. This approach leads to an innovative kind of architecture called “breathing architecture.”

  1. Exploration and Practice of Architectural Charting and Drawing Recognition Materials Development%建筑制图与识图教材开发的探索与实践

    Institute of Scientific and Technical Information of China (English)

    霍瑛

    2014-01-01

    From the perspective of course arrangement of construction industry college students, the Architectural Charting and Drawing Recognition course reform is imperative. As the basic professional technical courses of architecture major and project cost major, nowadays, if we still follow the current method of teaching, talent training will be affected. For actual posts competency-based training, this paper objectively describes the importance and necessity of the method reform of architectural charting and drawing recognition course teaching, and investigates the specific implementation programs and checks its feasibility by practices.%从现代的建筑行业大学生课程安排来看,对《建筑制图与识图》课程改革势在必行。作为建筑专业和工程造价专业的基础专业技术课,现如今如果还是沿用目前的方法进行教学,将会影响到建筑人才的培养,为此本文以培养实际上岗能力为主,客观叙述建筑制图和识图课程教学的方式改革的重要性与必然性,探讨相关具体的实施方案,并以实践以检查其可行性。

  2. Collaborative Micro Aerial Vehicle Exploration of Outdoor Environments

    Science.gov (United States)

    2010-02-01

    51 3.5.4 Perceived First Order Control . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53 3.6 Architecture ...Communication architecture between Micro Aerial Vehicle Exploration of an Unknown Environment (MAV-VUE), MAVServer, and MAV...66 MVC Model-Viewer-Controller

  3. Mapping the Intangible: On Adaptivity and Relational Prototyping in Architectural Design

    DEFF Research Database (Denmark)

    Bolbroe, Cameline

    2016-01-01

    an investigation into contemporary architectural discourse supported by examples from practice, I frame a shift in attention from the architectural object alone to the act of inhabitation. Further, I argue that the act of inhabitation is a process of negotiation and exchange between the architectural object...... to construct a full-scale prototyping genre, which equips and capacitates the architectural professional with a means to explore and operationalize adaptive qualities of architecture such as temporality, memory, learning and emergence....

  4. Urogenital tumors

    Energy Technology Data Exchange (ETDEWEB)

    Weller, R.E.

    1994-03-01

    An overview is provided for veterinary care of urogenital tumors in companion animals, especially the dog. Neoplasms discussed include tumors of the kidney, urinary bladder, prostate, testis, ovary, vagina, vulva and the canine transmissible venereal tumor. Topics addressed include description, diagnosis and treatment.

  5. Brain Tumors

    Science.gov (United States)

    A brain tumor is a growth of abnormal cells in the tissues of the brain. Brain tumors can be benign, with no cancer cells, ... cancer cells that grow quickly. Some are primary brain tumors, which start in the brain. Others are ...

  6. Architecture for the silvering society

    DEFF Research Database (Denmark)

    Andersson, Jonas E; Rönn, Magnus

    Abstract In the context of the universal ageing process that is currently taking place in western society, the organization of architecture competitions that deals with space for dependent ageing comes of relevance. Based on the welfare regime theory, it could be argued that this type of architec......Abstract In the context of the universal ageing process that is currently taking place in western society, the organization of architecture competitions that deals with space for dependent ageing comes of relevance. Based on the welfare regime theory, it could be argued that this type......, since a spatial innovation is juxtaposed with sociopolitical reform work of the welfare regime. The present study is an explorative study of programming competition documents and winning entries that were part of the Swedish governmental initiative of 2010,” Growing older, Living well,” to innovate...

  7. Chip architecture - A revolution brewing

    Science.gov (United States)

    Guterl, F.

    1983-07-01

    Techniques being explored by microchip designers and manufacturers to both speed up memory access and instruction execution while protecting memory are discussed. Attention is given to hardwiring control logic, pipelining for parallel processing, devising orthogonal instruction sets for interchangeable instruction fields, and the development of hardware for implementation of virtual memory and multiuser systems to provide memory management and protection. The inclusion of microcode in mainframes eliminated logic circuits that control timing and gating of the CPU. However, improvements in memory architecture have reduced access time to below that needed for instruction execution. Hardwiring the functions as a virtual memory enhances memory protection. Parallelism involves a redundant architecture, which allows identical operations to be performed simultaneously, and can be directed with microcode to avoid abortion of intermediate instructions once on set of instructions has been completed.

  8. An Embodied Architecture

    Directory of Open Access Journals (Sweden)

    Frances Downing

    2012-10-01

    Full Text Available An architecture of the body is emerging out of theories of biology, complexity, and systems through the use of an evolving organism as its metaphor. Autopoiesis is the term used by biologists to describe the realm of existence for a living organism as it slides between the interchange of structure and information. Incoming information is filtered through the organism for its usefulness in the art of staying alive. Structural or organizational changes evolve as the organism adjusts to new information. To remain a viable organism—to survive—means that an entity must keep evolving without surrendering identity. Humans must maintain an embodied identity, often referred to as an organized self (Maturana & Varela, 1980, 1987, while viably exchanging information with other entities and the environment. This operation creates a topological boundary across which the communication takes place. Cognitive theorists and researchers have proposed that the animal condition is one of Embodied Realism; that is, animals such as we humans, are embodied, using our bodies to create basic metaphors, and, that we do this in a“real” world. The role of cognition in this equation is to allow humans the use of embodiment to explore abstract ideas through metaphor—such as “grasping an idea” (Lakoff &Johnson, 2003. In doing so, it allows the invention of an evolving language that refers to things “outside” our skin,like other entities and places. Autopoiesis describes the activities at the “edge” or boundary of an organism. The linguistic act can, therefore, be identified as fundamental medium for communication in the edge, between inside and outside, that assures the autopoiesis of place.In our own bodies, flesh is the biological manifest of the edge or boundary condition. Our understanding of flesh is that it is another of our organs; and at the same time, all organs are also bounded by flesh. It serves as a porous filter, delicate and complicated

  9. Relationship between Meaning and Expression in Architecture Design

    Institute of Scientific and Technical Information of China (English)

    LiKun

    2002-01-01

    During the evolvement of architecture,the research on architectural form and structure as well as different ways to express and realize architectural thoughts is constantly the focus of many architects,This paper illustrates the mutual influence of the ways of expression and design of architecture to people's understanding of the meaning of architecture throughout the history of their efforts and exploration.the paper also discusses the extensive usage of virtual-realith approach through computer technology,It points out that the traditional architectural standpoint will undergo breakthrough by the emergence of new expression and design method.In this way,people's understanding of architecture will be more profound and lasting.

  10. The role of material evidence in architectural research

    DEFF Research Database (Denmark)

    2011-01-01

    of knowledges that inform architectural thinking. Architectural reflection is allied with it media. It is through the drawing, the model and the built that architecture is conceived and developed. In practice based research working through design means reflecting through the production of material evidence......The following texts explore the production of knowledge in architectural research. Focussing on a wide definition of practice led research, the aim for these texts is to discuss how the practices of architectural design; drawing, modelling, prototyping and building embody a particular set...... are deliberately wide apart. Spanning between the highly speculative and the pragmatic, our aim is to suggest that practice based methods are used across all forms of architectural thinking. Where the structure of the book suggests a divide between the conceiving and the realisation of architecture, what we hope...

  11. Generation of non-overlapping fiber architecture

    DEFF Research Database (Denmark)

    Chapelle, Lucie; Lévesque, M.; Brøndsted, Povl;

    2015-01-01

    Numerical models generating actual fiber architecture by including parameters such as the fiber geometry and arrangement are a powerful tool to explore the relation between the fiber architecture and mechanical properties. The generation of virtual architectures of fibrous materials is the first...... step toward the computation of their physical properties. In this work, a realistic 3D model is developed to describe the architecture of a complex fiber structure. The domain of application of the model could include natural fibers composites, wood fibers materials, papers, mineral and steel wools...... and polymer networks. The model takes into account the complex geometry of the fiber arrangement in which a fiber can be modeled with a certain degree of bending while keeping a main fiber orientation. The model is built in two steps. First, fibers are generated as a chain of overlapping spheres or as a chain...

  12. Multiple-Morphs Adaptive Stream Architecture

    Institute of Scientific and Technical Information of China (English)

    Mei Wen; Nan Wu; Hai-Yan Li; Chun-Yuan Zhang

    2005-01-01

    In modern VLSI technology, hundreds of thousands of arithmetic units fit on a 1cm2 chip. The challenge is supplying them with instructions and data. Stream architecture is able to solve the problem well. However, the applications suited for typical stream architecture are limited. This paper presents the definition of regular stream and irregular stream,and then describes MASA (Multiple-morphs Adaptive Stream Architecture) prototype system which supports different execution models according to applications' stream characteristics. This paper first discusses MASA architecture and stream model, and then explores the features and advantages of MASA through mapping stream applications to hardware.Finally MASA is evaluated by ten benchmarks. The result is encouraging.

  13. A Network Software Architecture Suitable for Service Customization

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    This paper explores the service customization in the view of network software architectures. The authors first abstract a network system into a framework that consists of several layered basic systems and then propose a component-based network software architecture for one basic system of network software, which is suitable for service customization. The network software architecture is formalized with the theory of Communicating Sequential Process and show its possible applications in areas of personal service environment and service customization.

  14. The Mothership Mission Architecture

    Science.gov (United States)

    Ernst, S. M.; DiCorcia, J. D.; Bonin, G.; Gump, D.; Lewis, J. S.; Foulds, C.; Faber, D.

    2015-12-01

    The Mothership is considered to be a dedicated deep space carrier spacecraft. It is currently being developed by Deep Space Industries (DSI) as a mission concept that enables a broad participation in the scientific exploration of small bodies - the Mothership mission architecture. A Mothership shall deliver third-party nano-sats, experiments and instruments to Near Earth Asteroids (NEOs), comets or moons. The Mothership service includes delivery of nano-sats, communication to Earth and visuals of the asteroid surface and surrounding area. The Mothership is designed to carry about 10 nano-sats, based upon a variation of the Cubesat standard, with some flexibility on the specific geometry. The Deep Space Nano-Sat reference design is a 14.5 cm cube, which accommodates the same volume as a traditional 3U CubeSat. To reduce cost, Mothership is designed as a secondary payload aboard launches to GTO. DSI is offering slots for nano-sats to individual customers. This enables organizations with relatively low operating budgets to closely examine an asteroid with highly specialized sensors of their own choosing and carry out experiments in the proximity of or on the surface of an asteroid, while the nano-sats can be built or commissioned by a variety of smaller institutions, companies, or agencies. While the overall Mothership mission will have a financial volume somewhere between a European Space Agencies' (ESA) S- and M-class mission for instance, it can be funded through a number of small and individual funding sources and programs, hence avoiding the processes associated with traditional space exploration missions. DSI has been able to identify a significant interest in the planetary science and nano-satellite communities.

  15. Architecture humanitarian emergencies

    DEFF Research Database (Denmark)

    Gomez-Guillamon, Maria; Eskemose Andersen, Jørgen; Contreras, Jorge Lobos

    2013-01-01

    Introduced by scientific articles conserning architecture and human rights in light of cultures, emergencies, social equality and sustainability, democracy, economy, artistic development and science into architecture. Concluding in definition of needs for new roles, processes and education of arc......, Architettura di Alghero in Italy, Architecture and Design of Kocaeli University in Turkey, University of Aguascalientes in Mexico, Architectura y Urbanismo of University of Chile and Escuela de Architectura of Universidad Austral in Chile....

  16. IT Architecture For Dummies

    CERN Document Server

    Hausman, Kalani Kirk

    2010-01-01

    A solid introduction to the practices, plans, and skills required for developing a smart system architecture. Information architecture combines IT skills with business skills in order to align the IT structure of an organization with the mission, goals, and objectives of its business. This friendly introduction to IT architecture walks you through the myriad issues and complex decisions that many organizations face when setting up IT systems to work in sync with business procedures. Veteran IT professional and author Kirk Hausman explains the business value behind IT architecture and provides

  17. Grid Architecture 2

    Energy Technology Data Exchange (ETDEWEB)

    Taft, Jeffrey D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-01-01

    The report describes work done on Grid Architecture under the auspices of the Department of Electricity Office of Electricity Delivery and Reliability in 2015. As described in the first Grid Architecture report, the primary purpose of this work is to provide stakeholder insight about grid issues so as to enable superior decision making on their part. Doing this requires the creation of various work products, including oft-times complex diagrams, analyses, and explanations. This report provides architectural insights into several important grid topics and also describes work done to advance the science of Grid Architecture as well.

  18. Socialisation in Architectural Education: A View from East Africa

    Science.gov (United States)

    Olweny, Mark

    2017-01-01

    Purpose: Concern for the state of architectural education in East Africa was a catalyst for this exploration of socialisation, which sought to understand socialisation and its influence on educational outcomes in the region. Socialisation within architectural education has long been known to influence how students acquire important aspects of the…

  19. Transformation of Minarets in Contemporary Mosque Architecture in Turkey

    OpenAIRE

    Özgür Ürey

    2013-01-01

    This study aims to explore the usage, the formal and functional transformation of minarets in contemporary mosque architecture in Turkey, through a survey of the selected cases. The selected cases are the outstanding examples of Turkish contemporary mosque architecture. Their architects are innovative in their design decisions and displayed their own design approach and interpretation outside the main stream contemporary mosque design in T...

  20. Measures for Project Compliance with Enterprise Architecture

    DEFF Research Database (Denmark)

    Andersen, Peter; Carugati, Andrea; Svejvig, Per

    This paper presents the findings from a recent pilot study exploring how project compliance with enterprise architecture (EA) can be measured. This is a research area which has received very little attention in academic publications on EA. While some ways of measuring EA exist within the literature...

  1. Digital architecture, wearable computers and providing affinity

    DEFF Research Database (Denmark)

    Guglielmi, Michel; Johannesen, Hanne Louise

    2005-01-01

    will, through research, a workshop and participation in a cumulus competition, focus on the exploration of boundaries between digital architecture, performative space and wearable computers. Our design method in general focuses on the interplay between the performing body and the environment – between...

  2. Software Architecture : Framing Stakeholders' Concerns introduction

    NARCIS (Netherlands)

    Lago, Patricia; Avgeriou, Paris; Hilliard, Rich

    2010-01-01

    As noted earlier, some stakeholder concerns are well-served today by available architecture viewpoints, frameworks, or ADLs, while others aren't expressible with available, off-the-shelf approaches. Hence the theme of this special issue: exploring the space of architecting in the face of multiple st

  3. On Detailing in Contemporary Architecture

    DEFF Research Database (Denmark)

    Kristensen, Claus; Kirkegaard, Poul Henning

    2010-01-01

    / tactility can blur the meaning of the architecture and turn it into an empty statement. The present paper will outline detailing in contemporary architecture and discuss the issue with respect to architectural quality. Architectural cases considered as sublime piece of architecture will be presented...

  4. Exploration Laboratory Analysis - ARC

    Science.gov (United States)

    Krihak, Michael K.; Fung, Paul P.

    2012-01-01

    The Exploration Laboratory Analysis (ELA) project supports the Exploration Medical Capability (ExMC) risk, Risk of Inability to Adequately Treat an Ill or Injured Crew Member, and ExMC Gap 4.05: Lack of minimally invasive in-flight laboratory capabilities with limited consumables required for diagnosing identified Exploration Medical Conditions. To mitigate this risk, the availability of inflight laboratory analysis instrumentation has been identified as an essential capability in future exploration missions. Mission architecture poses constraints on equipment and procedures that will be available to treat evidence-based medical conditions according to the Space Medicine Exploration Medical Conditions List (SMEMCL). The SMEMCL provided diagnosis and treatment for the evidence-based medical conditions and hence, a basis for developing ELA functional requirements.

  5. Architecture Framework for Fault Management Assessment And Design (AFFMAD) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Architecture Framework for Fault Management Assessment And Design (AFFMAD) is a constraint-checking system for FM trade space exploration that provides rigorous...

  6. Workflow automation architecture standard

    Energy Technology Data Exchange (ETDEWEB)

    Moshofsky, R.P.; Rohen, W.T. [Boeing Computer Services Co., Richland, WA (United States)

    1994-11-14

    This document presents an architectural standard for application of workflow automation technology. The standard includes a functional architecture, process for developing an automated workflow system for a work group, functional and collateral specifications for workflow automation, and results of a proof of concept prototype.

  7. Architecture and Stages

    DEFF Research Database (Denmark)

    Kiib, Hans

    2009-01-01

    as "experiencescape" - a space between tourism, culture, learning and economy. Strategies related to these challenges involve new architectural concepts and art as ‘engines' for a change. New expressive architecture and old industrial buildings are often combined into hybrid narratives, linking the past...

  8. SMRF architecture concepts

    NARCIS (Netherlands)

    Rossum, W.L. van; Wit, J.J.M. de; Otten, M.P.G.; Huizing, A.G.

    2011-01-01

    This presents three valuable applications of scalable multifunction RF (SMRF) systems. These systems allow radar, ESM, and communication functionality using a single front-end architecture. With the use of a novel system design tool, concepts for SMRF architectures for airborne, ground-based and nav

  9. Architecture and energy

    DEFF Research Database (Denmark)

    Marsh, Rob; Lauring, Michael

    2011-01-01

    Traditional low-energy architecture has not necessarily led to reduced energy consumption. A paradigm shift is proposed promoting pluralistic energy-saving strategies.......Traditional low-energy architecture has not necessarily led to reduced energy consumption. A paradigm shift is proposed promoting pluralistic energy-saving strategies....

  10. Digitally-Driven Architecture

    Directory of Open Access Journals (Sweden)

    Henriette Bier

    2014-07-01

    Full Text Available The shift from mechanical to digital forces architects to reposition themselves: Architects generate digital information, which can be used not only in designing and fabricating building components but also in embedding behaviours into buildings. This implies that, similar to the way that industrial design and fabrication with its concepts of standardisation and serial production influenced modernist architecture, digital design and fabrication influences contemporary architecture. While standardisation focused on processes of rationalisation of form, mass-customisation as a new paradigm that replaces mass-production, addresses non-standard, complex, and flexible designs. Furthermore, knowledge about the designed object can be encoded in digital data pertaining not just to the geometry of a design but also to its physical or other behaviours within an environment. Digitally-driven architecture implies, therefore, not only digitally-designed and fabricated architecture, it also implies architecture – built form – that can be controlled, actuated, and animated by digital means.In this context, this sixth Footprint issue examines the influence of digital means as pragmatic and conceptual instruments for actuating architecture. The focus is not so much on computer-based systems for the development of architectural designs, but on architecture incorporating digital control, sens­ing, actuating, or other mechanisms that enable buildings to inter­act with their users and surroundings in real time in the real world through physical or sensory change and variation.

  11. Teaching American Indian Architecture.

    Science.gov (United States)

    Winchell, Dick

    1991-01-01

    Reviews "Native American Architecture," by Nabokov and Easton, an encyclopedic work that examines technology, climate, social structure, economics, religion, and history in relation to house design and the "meaning" of space among tribes of nine regions. Describes this book's use in a college course on Native American architecture. (SV)

  12. Software Architecture Evolution

    Science.gov (United States)

    Barnes, Jeffrey M.

    2013-01-01

    Many software systems eventually undergo changes to their basic architectural structure. Such changes may be prompted by new feature requests, new quality attribute requirements, changing technology, or other reasons. Whatever the causes, architecture evolution is commonplace in real-world software projects. Today's software architects, however,…

  13. Applying neuroscience to architecture.

    Science.gov (United States)

    Eberhard, John P

    2009-06-25

    Architectural practice and neuroscience research use our brains and minds in much the same way. However, the link between neuroscience knowledge and architectural design--with rare exceptions--has yet to be made. The concept of linking these two fields is a challenge worth considering.

  14. Architecture as liminal Space

    Directory of Open Access Journals (Sweden)

    Nilly Harag

    2015-11-01

    Full Text Available The point of departure of the architectural project has to stem from the combination of inner and outer journeys in between the real or imagined limits. The pressing challenge is to destabilize the neat division of architecture into separate bodies of knowledge and pose the architect’s mode of action on the threshold between the concrete and the universal. Architecture is a lens, an instrument one looks through to bring new perspectives into focus, enabling the transformation of experience from a magnified self-concentrated space to a wide horizon. Architecture narrates relations between spaces and examines its validity through signifying practices of design. Design for itself becomes the language of the current, of the immediate fashion. Architecture can fulfill peoples’ dreams and miraculously can provide them tools to invent new ones: Curiosity is the first motive to act.

  15. Can architecture be barbaric?

    Science.gov (United States)

    Hürol, Yonca

    2009-06-01

    The title of this article is adapted from Theodor W. Adorno's famous dictum: 'To write poetry after Auschwitz is barbaric.' After the catastrophic earthquake in Kocaeli, Turkey on the 17th of August 1999, in which more than 40,000 people died or were lost, Necdet Teymur, who was then the dean of the Faculty of Architecture of the Middle East Technical University, referred to Adorno in one of his 'earthquake poems' and asked: 'Is architecture possible after 17th of August?' The main objective of this article is to interpret Teymur's question in respect of its connection to Adorno's philosophy with a view to make a contribution to the politics and ethics of architecture in Turkey. Teymur's question helps in providing a new interpretation of a critical approach to architecture and architectural technology through Adorno's philosophy. The paper also presents a discussion of Adorno's dictum, which serves for a better understanding of its universality/particularity.

  16. Product Architecture Modularity Strategies

    DEFF Research Database (Denmark)

    Mikkola, Juliana Hsuan

    2003-01-01

    The focus of this paper is to integrate various perspectives on product architecture modularity into a general framework, and also to propose a way to measure the degree of modularization embedded in product architectures. Various trade-offs between modular and integral product architectures...... and how components and interfaces influence the degree of modularization are considered. In order to gain a better understanding of product architecture modularity as a strategy, a theoretical framework and propositions are drawn from various academic literature sources. Based on the literature review......, the following key elements of product architecture are identified: components (standard and new-to-the-firm), interfaces (standardization and specification), degree of coupling, and substitutability. A mathematical function, termed modularization function, is introduced to measure the degree of modularization...

  17. Architecture as Ars Combinatoria

    Directory of Open Access Journals (Sweden)

    Francesco Cacciatore

    2015-11-01

    Full Text Available Architecture today, no longer reflects the limits of experimentation and innovation. An extremely low-tech art whose field of possibilities consists of choosing and using that which has already been done in the past. It is because of this that the key skill a designer should have is the ability to recognize the complexity in forms around them: cities have the widest programming opportunities for architecture, in the two-way relationship that is established from the city that takes form in architecture and an architecture that finds its place in the contemporary city. Thus, architecture has its foundation in hospitality, an element that differentiates it significantly from the design.

  18. Conceptual service architecture for adaptive mobile location services

    DEFF Research Database (Denmark)

    Schou, Saowanee

    2008-01-01

    This paper presents a conceptual service architecture for adaptive mobile location services designed to be used on the next generation wireless network. The developed service architecture consists of a set of concepts, principles, rules and guidelines for constructing, deploying, and operating...... the mobile location services. The service architecture identifies the components required to build the mobile location services and describes how these components are combined and how they should interact. As a means of exploring the developed conceptual service architecture, an illustrative case study...

  19. Comparative Study of Bio-implantable Acoustic Generator Architectures

    Science.gov (United States)

    Christensen, D.; Roundy, S.

    2013-12-01

    This paper is a comparative study of the design spaces of two bio-implantable acoustically excited generator architectures: the thickness-stretch-mode circular piezoelectric plate and the bending-mode unimorph piezoelectric diaphragm. The generators are part of an acoustic power transfer system for implanted sensors and medical devices such as glucose monitors, metabolic monitors, drug delivery systems, etc. Our studies indicate that at small sizes the diaphragm architecture outperforms the plate architecture. This paper will present the results of simulation studies and initial experiments that explore the characteristics of the two architectures and compare their performance.

  20. Modular Architecture for the Measurement of Space Radiation

    Science.gov (United States)

    Delaune, Paul; Turner, Kathryn; Holland, S. Douglas; Carson, William R.; Riman, Fadi

    2007-01-01

    A modular architecture has been conceived for the design of radiation-monitoring instruments used aboard spacecraft and in planetary-exploration settings. This architecture reflects lessons learned from experience with prior radiation-monitoring instruments. A prototype instrument that embodies the architecture has been developed as part of the Mars Advanced Radiation Acquisition (MARA) project. The architecture is also applicable on Earth for radiation-monitoring instruments in research of energetic electrically charged particles and instruments monitoring radiation for purposes of safety, military defense, and detection of hidden nuclear devices and materials.

  1. Minimalism in architecture: Abstract conceptualization of architecture

    Directory of Open Access Journals (Sweden)

    Vasilski Dragana

    2015-01-01

    Full Text Available Minimalism in architecture contains the idea of the minimum as a leading creative tend to be considered and interpreted in working through phenomena of empathy and abstraction. In the Western culture, the root of this idea is found in empathy of Wilhelm Worringer and abstraction of Kasimir Malevich. In his dissertation, 'Abstraction and Empathy' Worringer presented his thesis on the psychology of style through which he explained the two opposing basic forms: abstraction and empathy. His conclusion on empathy as a psychological basis of observation expression is significant due to the verbal congruence with contemporary minimalist expression. His intuition was enhenced furthermore by figure of Malevich. Abstraction, as an expression of inner unfettered inspiration, has played a crucial role in the development of modern art and architecture of the twentieth century. Abstraction, which is one of the basic methods of learning in psychology (separating relevant from irrelevant features, Carl Jung is used to discover ideas. Minimalism in architecture emphasizes the level of abstraction to which the individual functions are reduced. Different types of abstraction are present: in the form as well as function of the basic elements: walls and windows. The case study is an example of Sou Fujimoto who is unequivocal in its commitment to the autonomy of abstract conceptualization of architecture.

  2. Pindborg tumor

    Science.gov (United States)

    Caliaperoumal, Santhosh Kumar; Gowri, S.; Dinakar, J.

    2016-01-01

    Calcifying epithelial odontogenic tumor (CEOT), also known as Pindborg tumor, is a rare odontogenic epithelial neoplasm. So far, nearly 200 cases have been reported in the literature. We are reporting a case of CEOT in a 42-year-old male patient with painless bony swelling in the mandible. The clinical, radiographic, and histopathologic features are discussed with relevant references. PMID:27041911

  3. Pindborg tumor

    Directory of Open Access Journals (Sweden)

    Santhosh Kumar Caliaperoumal

    2016-01-01

    Full Text Available Calcifying epithelial odontogenic tumor (CEOT, also known as Pindborg tumor, is a rare odontogenic epithelial neoplasm. So far, nearly 200 cases have been reported in the literature. We are reporting a case of CEOT in a 42-year-old male patient with painless bony swelling in the mandible. The clinical, radiographic, and histopathologic features are discussed with relevant references.

  4. Enterprise Architecture in the Company Management Framework

    Directory of Open Access Journals (Sweden)

    Bojinov Bojidar Violinov

    2016-11-01

    Full Text Available The study aims to explore the role and importance of the concept of enterprise architecture in modern company management. For this purpose it clarifies the nature, scope, components of the enterprise architecture and relationships within it using the Zachman model. Based on the critical analysis of works by leading scientists, there presented a definition of enterprise architecture as a general description of all elements of strategic management of the company combined with description of its organizational, functional and operational structure, including the relationship between all tangible and intangible resources essential for its normal functioning and development. This in turn enables IT enterprise architecture to be defined as a set of corporate IT resources (hardware, software and technology, their interconnection and integration within the overall architecture of the company, as well as their formal description, methods and tools for their modeling and management in order to achieve strategic business goals of the organization. In conclusion the article summarizes the significance and role of enterprise architecture for strategic management of the company in today’s digital economy. The study underlines the importance of an integrated multidisciplinary approach to the work of a contemporary company, and the need for adequate matching and alignment of IT with business priorities and objectives of the company.

  5. Non-Toxic Ionic Liquid Fuels for Exploration Applications Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Challenges arise in the propulsion systems for the new exploration architecture. The currently operational and proven storable hypergolic systems raise toxicity...

  6. The Architectural Practice of Regeneration

    Directory of Open Access Journals (Sweden)

    Tom Van Malderen

    2013-09-01

    Full Text Available In form and in content, cities are the epitome of diversity. This state is the result of the accumulation of layers of history, of construction, of demolition and reconstruction cycles. These tensions are the catalyst for the emergence of new urban forms and participate in the construction of heritage. As such they should be encouraged. As important as the existing fabric of the city is, its evolution to accommodate the ever-changing needs and fashions of its inhabitants is paramount. For regeneration to be successful it must inscribe itself in this process and it must be driven by an understanding of the environment where it occurs. This paper explores, through the lens of an architectural practice, some design processes and architectural proposals that have been generated by working on the Valletta harbours. It also discusses the necessary dynamics required to accommodate stakeholder engagement and planning policy while ensuring design quality and the perpetuation of the creative process inherent to the city. Finally, the paper introduces, as a possible future, the experiments and studies of the practice on the wider Valletta, putting into perspective the benefits of theoretical research combined with formal and aesthetic explorations of the harbour region.

  7. Data-Centric Enterprise Architecture

    OpenAIRE

    Zeinab Rajabi; Maryam Nooraei Abade

    2012-01-01

    Enterprises choose Enterprise Architecture (EA) solution, in order to overcome dynamic business challenges and in coordinate various enterprise elements. In this article, a solution is suggested for the Enterprise Architecture development. The solution focuses on architecture data in the Enterprise Architecture development process. Data-centric architecture approach is preferred product-centric architecture approach. We suggest using Enterprise Ontology (EO) as context for collecting architec...

  8. Hybrid architecture: object, landscape, infrastructure

    OpenAIRE

    Pinto de Freitas, Rita

    2011-01-01

    The concept of "hybrid architecture" developed in this study considers hybrid all architecture that is at once object, landscape and infrastructure. Hybrid architecture, pushed by the fact that it concentrates in a single architectural intervention a triple object-, landscape- and infrastructure-related nature, generates architectural answers with very specific features, and its study achieves following goals: 1: Clarify the term hybrid related to architectural intervention; 2: Tran...

  9. Theory and ideology of Catalan postmodern architecture

    Directory of Open Access Journals (Sweden)

    Stevanović Vladimir

    2015-01-01

    Full Text Available This paper aims to review and examine the theoretical and ideological models by means of which the discourse on Catalan postmodern architecture was constructed. The focus is on the analysis of the texts produced by Catalan theorist de Solà- Morales, who as of the second half of the eighties was the one most engaged in presenting Catalan architecture as a specific way of architectural practice, which is as such distinguished from the other postmodern tendencies. Given that he was well versed in the concept of weak thought (il pensiero debole - developed by his peer, Italian philosopher of hermeneutic-nihilistic provenance Vattimo - de Solà-Morales continuously implemented and introduced the ideas of the weak thought in the framework of his own architectural theorizations. In this manner, Catalan architecture acquired the status of being an architectural derivate of the weak thought, from which de Solà-Morales will soon develop the well known concept of weak architecture. The aim of this paper is to explore the possible ideological motifs of de Solà-Morales's orientation towards the weak thought as a theoretical model. In this sense, Catalan architecture can be placed in the center of the dynamic relation on whose one end sits the appropriation of a philosophical-theoretical view, and on the other an aspiration to insistence on the Catalan national identity. Reduction and instrumentalization of a theory in favor of ideological implications lead to a situation in which the main motifs of the weak thought have been let down.

  10. Fractal Geometry of Architecture

    Science.gov (United States)

    Lorenz, Wolfgang E.

    In Fractals smaller parts and the whole are linked together. Fractals are self-similar, as those parts are, at least approximately, scaled-down copies of the rough whole. In architecture, such a concept has also been known for a long time. Not only architects of the twentieth century called for an overall idea that is mirrored in every single detail, but also Gothic cathedrals and Indian temples offer self-similarity. This study mainly focuses upon the question whether this concept of self-similarity makes architecture with fractal properties more diverse and interesting than Euclidean Modern architecture. The first part gives an introduction and explains Fractal properties in various natural and architectural objects, presenting the underlying structure by computer programmed renderings. In this connection, differences between the fractal, architectural concept and true, mathematical Fractals are worked out to become aware of limits. This is the basis for dealing with the problem whether fractal-like architecture, particularly facades, can be measured so that different designs can be compared with each other under the aspect of fractal properties. Finally the usability of the Box-Counting Method, an easy-to-use measurement method of Fractal Dimension is analyzed with regard to architecture.

  11. Plastic Super Models: aesthetics, architecture and the model of emergence

    Directory of Open Access Journals (Sweden)

    Pia Ednie-Brown

    2008-01-01

    Full Text Available Modelling is at the core of what architects do, rendering the discipline especially fragile and sensitive to shifts in the nature of models and modelling. A digitally-based, explorative architectural milieu has been actively modelling in tune with a socio-cultural paradigm related to the concept of emergence, presenting numerous challenges to a range of assumptions about the activity of architectural design. This paper explores how this milieu has acted to unsettle the cool containments of architectural composure by bringing affective activity emphatically to the foreground.

  12. Laminations: defining the role of architecture in the context of narrative, tectonic and time

    OpenAIRE

    Kingston, Jennifer

    2013-01-01

    non-peer-reviewed This thesis paper calls for an architecture that returns to the realm of the human, the phenomenological. Through explorations of perception and the role of narrative in building and genesis of architectural thought, it aims to develop a mode of understanding architecture that places the human experience at its centre.

  13. Integrated Data Assimilation Architecture Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Integrated Data Assimilation Architecture (IDAA) is a middleware architecture that facilitates the incorporation of heterogeneous sensing and control devices...

  14. RECONSTRUCTING DECONSTRUCTION IN ARCHITECTURE

    Directory of Open Access Journals (Sweden)

    IDHAM Noor Cholis

    2013-12-01

    Full Text Available This paper examines deconstruction in architecture and forms used, which triggered by dispute of form and its scientification claimed by deconstructivists. Deconstruction terminologyis studied in the first part related to architecture field as a base knowledge. Some sample works of known deconstructionist architects are assessed in order to understand how their building is deconstructed and what forms they used. Discussion about form and its relation to other fields is then pursued by discussing the involvement of terminology of science, aesthetic pattern, and human life. The results of this discussion give clear understanding how form related to deconstruction in architecture are used.

  15. ARCHITECTURE INFORMS HISTORY

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Clusters of ancient architecture in central China have recently been entered on the world heritage list A group of ancient architecture in Dengfeng,central China’s Henan Province,was added to the world heritage list at the 34th session of the World Heritage Committee in Brazil on August 1 this year.The architectural collection is China’s 39th property inscribed on the list,and the third world heritage site in the province after the Longmen Grottoes and Yinxu in Anyang,site of the capital of the late Shang Dynasty(1600-1046 B.C.).

  16. Adaptive Architectural Envelope

    DEFF Research Database (Denmark)

    Foged, Isak Worre; Kirkegaard, Poul Henning

    2010-01-01

    . The general scopes of this paper are to develop a new adaptive kinetic architectural structure, particularly a reconfigurable architectural structure which can transform body shape from planar geometries to hyper-surfaces using different control strategies, i.e. a transformation into more than one or two...... different shape alternatives. The adaptive structure is a proposal for a responsive building envelope which is an idea of a first level operational framework for present and future investigations towards performance based responsive architectures through a set of responsive typologies. A mock- up concept...

  17. Computer architecture technology trends

    CERN Document Server

    1991-01-01

    Please note this is a Short Discount publication. This year's edition of Computer Architecture Technology Trends analyses the trends which are taking place in the architecture of computing systems today. Due to the sheer number of different applications to which computers are being applied, there seems no end to the different adoptions which proliferate. There are, however, some underlying trends which appear. Decision makers should be aware of these trends when specifying architectures, particularly for future applications. This report is fully revised and updated and provides insight in

  18. The Exploration and Research Relating to Landscape Architecture Specialty Development in Traditional Normal Colleges of Anhui Province%安徽省传统师范类院校园林专业发展前景的探索与研究

    Institute of Scientific and Technical Information of China (English)

    王敉敉; 姜双林

    2012-01-01

    随着近几年园林专业的火爆,安徽省部分师范院校也逐渐开办了园林专业,作为师范院校的新专业,办学模式不同于老牌的农林院校,也不同于工科和艺术类高校,在发展过程中有误区,也存在机遇,本文就专业发展前景,探索师范院校园林专业改革和创新的新思路。%In recent years , along with the hot major Landscape Architecture , some normal colleges in anhui province gradually have establised the new major--landscape architecture. As the new major, the school--running mode in normal colle- ges is not only different from the renowned agricultural colleges, but also different from the engineering and science college, the university of arts. In the process of development, the new major have some difficulties and opportunities. With regard to the de- velopment prospects,this thesis tends to explore the new method of reform and innovation in accordance with the landscape ar- chitecture of normal colleges

  19. Architectures of prototypes and architectural prototyping

    DEFF Research Database (Denmark)

    Hansen, Klaus Marius; Christensen, Michael; Sandvad, Elmer;

    1998-01-01

    together as a team, but developed a prototype that more than fulfilled the expectations of the shipping company. The prototype should: - complete the first major phase within 10 weeks, - be highly vertical illustrating future work practice, - continuously live up to new requirements from prototyping...... sessions with users, - evolve over a long period of time to contain more functionality - allow for 6-7 developers working intensively in parallel. Explicit focus on the software architecture and letting the architecture evolve with the prototype played a major role in resolving these conflicting......This paper reports from experience obtained through development of a prototype of a global customer service system in a project involving a large shipping company and a university research group. The research group had no previous knowledge of the complex business of shipping and had never worked...

  20. 论知识管理和信息构建%On Knowledge Management & Information Architecture

    Institute of Scientific and Technical Information of China (English)

    张新民; 梁战平

    2003-01-01

    The paper outlines the concept and implementation process of knowledge management, introduces a new domain of study in information science, that is, the concept, composition and process of information architecture, and explores the relationship between knowledge aumagement and information architecture.

  1. Analysis of Architecture Pattern Usage in Legacy System Architecture Documentation

    NARCIS (Netherlands)

    Harrison, Neil B.; Avgeriou, Paris

    2008-01-01

    Architecture patterns are an important tool in architectural design. However, while many architecture patterns have been identified, there is little in-depth understanding of their actual use in software architectures. For instance, there is no overview of how many patterns are used per system or wh

  2. Robot Electronics Architecture

    Science.gov (United States)

    Garrett, Michael; Magnone, Lee; Aghazarian, Hrand; Baumgartner, Eric; Kennedy, Brett

    2008-01-01

    An electronics architecture has been developed to enable the rapid construction and testing of prototypes of robotic systems. This architecture is designed to be a research vehicle of great stability, reliability, and versatility. A system according to this architecture can easily be reconfigured (including expanded or contracted) to satisfy a variety of needs with respect to input, output, processing of data, sensing, actuation, and power. The architecture affords a variety of expandable input/output options that enable ready integration of instruments, actuators, sensors, and other devices as independent modular units. The separation of different electrical functions onto independent circuit boards facilitates the development of corresponding simple and modular software interfaces. As a result, both hardware and software can be made to expand or contract in modular fashion while expending a minimum of time and effort.

  3. Architecture for the senses

    DEFF Research Database (Denmark)

    Ryhl, Camilla

    2009-01-01

    findings from the PhD thesis 'A House for the Senses' by the author, a study of architectural requirements in housing design implied by a sensory impairment. The empirical research project is based on qualitative interviews and 1:1 testing in existing housing with participants who were either blind, deaf......Accommodating sensory disabilities in architectural design requires specific design considerations. These are different from the ones included by the existing design concept 'accessibility', which primarily accommodates physical disabilites. Hence a new design concept 'sensory accessbility......' is presented as a parallel and complementary concept to the existing one. Sensory accessiblity accommodates sensory disabilities and describes architectural design requirements needed to ensure access to to the sensory experiences and architectural quality of a given space. The article is based on research...

  4. Analyzing architecture articles

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    In the present study, we express the quality, function, and characteristics of architecture to help people comprehensively understand what architecture is. We also reveal the problems and conflict found in population, land, water resources, pollution, energy, and the organization systems in construction. China’s economy is transforming. We should focus on the cities, architectural environment, energy conservation, emission-reduction, and low-carbon output that will result in successful green development. We should macroscopically and microscopically analyze the development, from the natural environment to the artificial environment; from the relationship between human beings and nature to the combination of social ecology in cities, and farmlands. We must learn to develop and control them harmoniously and scientifically to provide a foundation for the methods used in architecture research.

  5. Ancient Chinese Architecture

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    CHINESE people have accu-mulated a great deal ofexperience in architecture,constantly improving building ma-terials and thus creating uniquebuilding styles.The history of ancient Chinesearchitechtural development can be

  6. Pituitary Tumors

    Science.gov (United States)

    ... impairment, and behavioral changes. Tumors can also either produce excessive amounts of hormone or limit how much hormone is produced. The hormones most commonly affected include: growth hormone (regulates body height and structure), prolactin (controls ...

  7. Ear Tumors

    Science.gov (United States)

    ... Japanese Espaniol Find information on medical topics, symptoms, drugs, procedures, news and more, written in everyday language. * This is ... the Ears, Nose, and Throat Additional Content Medical News Ear Tumors ... NOTE: This is the Consumer Version. DOCTORS: Click ...

  8. Tumor Grade

    Science.gov (United States)

    ... Other Funding Find NCI funding for small business innovation, technology transfer, and contracts Training Cancer Training at ... much of the tumor tissue has normal breast (milk) duct structures Nuclear grade : an evaluation of the ...

  9. Pituitary tumor

    Science.gov (United States)

    ... enough of its hormones. This condition is called hypopituitarism . The causes of pituitary tumors are unknown. Some ... Cyst Endocrine glands Gigantism Growth hormone test Hyperthyroidism Hypopituitarism Multiple endocrine neoplasia (MEN) I Prolactin blood test ...

  10. Wilms' Tumor

    Science.gov (United States)

    ... team and have training in child development, recreation, psychology or social work. If your child must remain ... conditions/wilms-tumor/basics/definition/CON-20043492 . Mayo Clinic Footer Legal Conditions and Terms Any use of ...

  11. What is a pediatric tumor?

    Directory of Open Access Journals (Sweden)

    Mora J

    2012-11-01

    Full Text Available Jaume Mora1,21Department of Oncology, 2Developmental Tumor Biology Laboratory, Hospital Sant Joan de Deu, Fundacio Sant Joan de Deu, Barcelona, SpainAbstract: Working together with medical oncologists, the question of whether a Ewing sarcoma in a 25-year-old is a pediatric tumor comes up repeatedly. Like Ewing's, some tumors present characteristically at ages that cross over what has been set as the definition of pediatrics (15 years, 18 years, or 21 years?. Pediatric oncology textbooks, surprisingly, do not address the subject of defining a pediatric tumor. They all begin with an epidemiology chapter defining the types of tumors appearing at distinct stages of childhood, adolescence, and young adulthood. Describing the epidemiology of tumors in relation to age, it becomes clear that the disease is related to the phenomenon of aging. The question, however, remains: is there a biological definition of what pediatric age is? And if so, will tumors occurring during this period of life have anything to do with such biological definition? With the aim of finding an objective definition, the fundamental concepts of what defines "pediatrics" was reviewed and then the major features of tumors arising during development were analyzed. The tumors were explored from the perspective of a host immersed in the normal process of growth and development. This physiological process, from pluripotential and undifferentiated cells, makes possible the differentiation, maturation, organization, and function of tissues, organs, and apparatus. A biological definition of pediatric tumors and the infancy–childhood–puberty classification of developmental tumors according to the infancy–childhood–puberty model of normal human development are proposed.Keywords: growth and development, pediatric tumor, infant, childhood and adolescence, pubertal tumors

  12. ARCHITECTURE INFORMS HISTORY

    Institute of Scientific and Technical Information of China (English)

    ZAN JIFANG

    2010-01-01

    @@ Agroup of ancient architecture in Dengfeng, central China's Henan Province, was added to the world heritage list at the 34th session of the World Heritage Committee in Brazil on August 1 this year. The architectural col-lection is China's 39th property inscribed on the list, and the third world heritage site in the province after the Longmen Grottoes and Yinxu in Anyang, site of the capital of the late Shang Dynasty (1600-1046 B.C.).

  13. BioArchitecture

    OpenAIRE

    Gunning, Peter

    2012-01-01

    Volume 1 has defined the scope of BioArchitecture. From the outset we have strived to ensure that BioArchitecture is not limited to the three major polymer systems of the cytoplasm. I am happy to say that a cursory glance at the contents of volume 1 makes it clear that we are interested in all aspects of bioarchitecture from molecules to polymers to cells to tissue to the organism.

  14. Essential software architecture

    CERN Document Server

    Gorton, Ian

    2011-01-01

    Job titles like ""Technical Architect"" and ""Chief Architect"" nowadays abound in software industry, yet many people suspect that ""architecture"" is one of the most overused and least understood terms in professional software development. Gorton's book tries to resolve this dilemma. It concisely describes the essential elements of knowledge and key skills required to be a software architect. The explanations encompass the essentials of architecture thinking, practices, and supporting technologies. They range from a general understanding of structure and quality attributes through technical i

  15. Artificial cognition architectures

    CERN Document Server

    Crowder, James A; Friess, Shelli A

    2013-01-01

    The goal of this book is to establish the foundation, principles, theory, and concepts that are the backbone of real, autonomous Artificial Intelligence. Presented here are some basic human intelligence concepts framed for Artificial Intelligence systems. These include concepts like Metacognition and Metamemory, along with architectural constructs for Artificial Intelligence versions of human brain functions like the prefrontal cortex. Also presented are possible hardware and software architectures that lend themselves to learning, reasoning, and self-evolution

  16. Climate and architecture

    DEFF Research Database (Denmark)

    Tind Kristensen, Eva; Friis Møller, Winnie; Rotne, Georg

    2010-01-01

    Climate and Architecture analyserer klimaets rolle i arkitekturen. Intentionen med bogen er at pege på nogle af de mange muligheder for bygningers klimaregulering, som et mere detaljeret studie af de lokale klimatiske forhold og den stedlige byggeskik tilbyder.......Climate and Architecture analyserer klimaets rolle i arkitekturen. Intentionen med bogen er at pege på nogle af de mange muligheder for bygningers klimaregulering, som et mere detaljeret studie af de lokale klimatiske forhold og den stedlige byggeskik tilbyder....

  17. Greek architecture now

    DEFF Research Database (Denmark)

    Skousbøll, Karin Merete

    2006-01-01

    With the author's Scandinavian viewpoint the aim of this book has been an investigation into contemporary Greek architecture and at the same time providing an understanding for its essential characteristics based on the historic, cultural heritage of Hellas.......With the author's Scandinavian viewpoint the aim of this book has been an investigation into contemporary Greek architecture and at the same time providing an understanding for its essential characteristics based on the historic, cultural heritage of Hellas....

  18. Ependymal tumors.

    Science.gov (United States)

    Moynihan, Timothy J

    2003-12-01

    Ependymal tumors are rare malignancies that arise from the cells that line the ventricles and central canal of the spinal cord. Although they are more common in children, adults may also be effected by ependymal tumors. Prognosis is dependent on tumor location, histology, especially for myxopapillary tumors that tend to occur in the lumbar spine, extent of surgical resection, and stage of disease. Standard therapy consists of complete resection when feasible. The exact role of adjuvant radiotherapy in patients with radiographically confirmed complete resection is poorly defined. Patients with known residual disease may benefit from local radiation therapy, but the extent of radiation field and total dose are controversial. Even in patients treated with involved field radiotherapy, most relapses occur within the original tumor bed, thus local control remains the biggest obstacle to effective therapy. Chemotherapy has little impact against this tumor and has no role in the adjuvant setting, outside of a well designed clinical trial, with the possible exception of children younger than 5 years in an effort to delay radiation. A minority of patients may respond to one of several chemotherapy regimens at the time of recurrence, but the impact of this therapy is limited. Newer treatment strategies are needed.

  19. Advanced connection systems for architectural glazing

    CERN Document Server

    Afghani Khoraskani, Roham

    2015-01-01

    This book presents the findings of a detailed study to explore the behavior of architectural glazing systems during and after an earthquake and to develop design proposals that will mitigate or even eliminate the damage inflicted on these systems. The seismic behavior of common types of architectural glazing systems are investigated and causes of damage to each system, identified. Furthermore, depending on the geometrical and structural characteristics, the ultimate horizontal load capacity of glass curtain wall systems is defined based on the stability of the glass components. Detailed attention is devoted to the incorporation of advanced connection devices between the structure of the building and the building envelope system in order to minimize the damage to glazed components. An innovative new connection device is introduced that results in a delicate and functional system easily incorporated into different architectural glazing systems, including those demanding maximum transparency.

  20. Towards infrastructural architecture and urban planning

    Directory of Open Access Journals (Sweden)

    Irene Pérez López

    2016-01-01

    Full Text Available This article conceptually explores notions of architecture, urban planning and infrastructure in order to discover structures that are able to integrate these three dimensions. Within this framework, and based on Stan Allen ́s text Urbanismo Infraestructural (Infrastructural Urban Planning, three categories of study are established. First, Flow Systems, reviews concepts and case studies from the perspective of flow systems, movement networks and architectures that use them as project material. Field Conditions, studies two cases, Berlin Haupstadt and PotteriesThinkbelt, as settings for a new way to build the place itself, supported by infrastructural systems, to generate solutions that leave the system open to new developments and possibilities. Lastly, Infrastructural Architecture and Urban Planning takes as a case study Japanese stations and associated malls, as they are settings where certain conditions are concentrated and expand, thus creating new types and new spatial and programmatic possibilities.

  1. The climatic performance of Indonesian traditional architecture: A comparison of Madurese and Javanese architecture

    Energy Technology Data Exchange (ETDEWEB)

    Setiadarma, E.; Schiler, M.; Koeing, P. [Univ. of Southern California, Los Angeles, CA (United States). School of Architecture

    1995-11-01

    This study explores and compares the climatic performance of both Madurese and Javanese architecture in terms of daylighting and ventilation, on wind behavior in the open spaces. The research begins with library research and proceeds to model testing using a wind tunnel. Various building layouts are tested to see their effects on outdoor air streams in the open spaces.

  2. New Energy Architecture. Myanmar

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-06-15

    A global transition towards a new energy architecture is under way, driven by countries' need to respond to the changing dynamics of economic growth, environmental sustainability and energy security. The World Economic Forum, in collaboration with Accenture, has created the New Energy Architecture Initiative to address and accelerate this transition. The Initiative supports the development of national strategies and policy frameworks as countries seek to achieve the combined goals of energy security and access, sustainability, and economic growth and development. The World Economic Forum has formed a partnership with the Ministry of Energy of Myanmar to help apply the Initiative's approach to this developing and resource-rich nation. The Asian Development Bank and the World Economic Forum's Project Adviser, Accenture, have collaborated with the Forum on this consultation process, and have been supported by relevant government, industry and civil society stakeholders. The consultation process aims to understand the nation's current energy architecture challenges and provide an overview of a path to a New Energy Architecture through a series of insights. These insights could form the basis for a long-term multistakeholder roadmap to build Myanmar's energy sector in a way that is secure and sustainable, and promotes economic growth as the country makes its democratic transition. While not all recommendations can be implemented in the near term, they do provide options for creating a prioritized roadmap for Myanmar's energy transition. This report is the culmination of a nine-month multistakeholder process investigating Myanmar's energy architecture. Over the course of many visits to the country, the team has conducted numerous interviews, multistakeholder workshops, and learning and data-gathering exercises to ensure a comprehensive range of information and views. The team has also engaged with a variety of stakeholders to better

  3. Tumor Types: Understanding Brain Tumors

    Science.gov (United States)

    ... Classification of Tumors of the Central Nervous System Purchase WHO Blue Book NBTS Official Statement Questions and ... Privacy Copyright Site Search Search term Submit Submit Facebook Twitter YouTube Flickr

  4. Exploration and Practice of Green Architecture: Design for the Sci-tech Archives Building of Tianjin Architecture Design Institute%绿色建筑的探究与实践——天津市建筑设计院科技档案楼设计

    Institute of Scientific and Technical Information of China (English)

    张津奕; 刘军; 刘祖玲; 曹宇

    2011-01-01

    The Design for Sci-tech Archives Building of Tianjin Architecture Design Institute fully embodies the design thinking of energy saving and emission reduotion It gives adequate consideration to effective use and practice on energy resource plants water environment wind environment, luminous environment and acoustic environment It chooses eco tech and facilities for solar collector system pnotovoltaic generatmg system and ground source heat pump system%介绍了天津市建筑设计院科技档案楼设计过程中充分考虑建筑在能源、植物、水环境、风环境、光环境、声环境等方面有效利用的做法;以及选用的太阳能热水系统、光伏发电系统、地源热泵供冷供热系统等生态技术及设备.

  5. Unrealized Architectural Projects in Lithuania: Historical Development

    Directory of Open Access Journals (Sweden)

    Indrė Gudelytė

    2012-05-01

    Full Text Available The “unrealized architectural projects” are the building projects, carried out under the specific design task and intended to be built in a particular place (site, though, for certain reasons and circumstances, have never been constructed. However, up to the present day, the topic of the “unbuilt” has been analyzed just episodically in literature and sources. The article touches upon the historical development of unrealized architectural works, as well as their artistic value and role within various historical periods of Lithuanian architecture. One of the chapters briefly reviews the relevance and development of unrealized projects during the period since Czarist Russian occupation (1795 to the restoration of Lithuanian independence (1990. Furthermore, the deeper analysis of the Soviet period (1940–1990 “dead” architecture is presented. While exploring “the unrealized”, attention has been also paid to what was actu ally built, therefore the prevailing architectural styles, tendencies and examples of the corresponding decade (in Lithuania and worldwide have been studied.Article in Lithuanian

  6. Space Architecture: The Role, Work and Aptitude

    Science.gov (United States)

    Griffin, Brand

    2014-01-01

    Space architecture has been an emerging discipline for at least 40 years. Has it arrived? Is space architecture a legitimate vocation or an avocation? If it leads to a job, what do employers want? In 2002, NASA Headquarters created a management position for a space architect whose job was to "lead the development of strategic architectures and identify high level requirements for systems that will accomplish the Nation's space exploration vision." This is a good job description with responsibility at the right level in NASA, but unfortunately, the office was discontinued two years later. Even though there is no accredited academic program or professional licensing for space architecture, there is a community of practitioners. They are civil servants, contractors and academicians supporting International Space Station and space exploration programs. In various ways, space architects currently contribute to human spaceflight, but there is a way for the discipline to be more effective in developing solutions to large scale complex problems. This paper organizes contributions from engineers, architects and psychologists into recommendations on the role of space architects in the organization, the process of creating and selecting options, and intrinsic personality traits including why they must have a high tolerance for ambiguity.

  7. A biologically inspired MANET architecture

    Science.gov (United States)

    Kershenbaum, Aaron; Pappas, Vasileios; Lee, Kang-Won; Lio, Pietro; Sadler, Brian; Verma, Dinesh

    2008-04-01

    Mobile Ad-Hoc Networks (MANETs), that do not rely on pre-existing infrastructure and that can adapt rapidly to changes in their environment, are coming into increasingly wide use in military applications. At the same time, the large computing power and memory available today even for small, mobile devices, allows us to build extremely large, sophisticated and complex networks. Such networks, however, and the software controlling them are potentially vulnerable to catastrophic failures because of their size and complexity. Biological networks have many of these same characteristics and are potentially subject to the same problems. But in successful organisms, these biological networks do in fact function well so that the organism can survive. In this paper, we present a MANET architecture developed based on a feature, called homeostasis, widely observed in biological networks but not ordinarily seen in computer networks. This feature allows the network to switch to an alternate mode of operation under stress or attack and then return to the original mode of operation after the problem has been resolved. We explore the potential benefits such an architecture has, principally in terms of the ability to survive radical changes in its environment using an illustrative example.

  8. Exploration Blueprint: Data Book

    Science.gov (United States)

    Drake, Bret G. (Editor)

    2007-01-01

    The material contained in this report was compiled to capture the work performed by the National Aeronautics and Space Administration's (NASA's) Exploration study team in the late 2002 timeframe. The "Exploration Blueprint Data Book" documents the analyses and findings of the 90-day Agency-wide study conducted from September - November 2002. During the summer of 2002, the NASA Deputy Administrator requested that a study be performed with the following objectives: (1) Develop the rationale for exploration beyond low-Earth orbit (2) Develop roadmaps for how to accomplish the first steps through humans to Mars (3) Develop design reference missions as a basis for the roadmaps 4) Make recommendations on what can be done now to effect this future This planning team, termed the Exploration Blueprint, performed architecture analyses to develop roadmaps for how to accomplish the first steps beyond LEO through the human exploration of Mars. The previous NASA Exploration Team activities laid the foundation and framework for development of NASA's Integrated Space Plan. The reference missions resulting from the analysis performed by the Exploration Blueprint team formed the basis for requirement definition, systems development, technology roadmapping, and risk assessments for future human exploration beyond low-Earth orbit. Emphasis was placed on developing recommendations on what could be done now to effect future exploration activities. The Exploration Blueprint team embraced the "Stepping Stone" approach to exploration where human and robotic activities are conducted through progressive expansion outward beyond low-Earth orbit. Results from this study produced a long-term strategy for exploration with near-term implementation plans, program recommendations, and technology investments. Specific results included the development of a common exploration crew vehicle concept, a unified space nuclear strategy, focused bioastronautics research objectives, and an integrated human

  9. Integrated Network Architecture for NASA's Orion Missions

    Science.gov (United States)

    Bhasin, Kul B.; Hayden, Jeffrey L.; Sartwell, Thomas; Miller, Ronald A.; Hudiburg, John J.

    2008-01-01

    NASA is planning a series of short and long duration human and robotic missions to explore the Moon and then Mars. The series of missions will begin with a new crew exploration vehicle (called Orion) that will initially provide crew exchange and cargo supply support to the International Space Station (ISS) and then become a human conveyance for travel to the Moon. The Orion vehicle will be mounted atop the Ares I launch vehicle for a series of pre-launch tests and then launched and inserted into low Earth orbit (LEO) for crew exchange missions to the ISS. The Orion and Ares I comprise the initial vehicles in the Constellation system of systems that later includes Ares V, Earth departure stage, lunar lander, and other lunar surface systems for the lunar exploration missions. These key systems will enable the lunar surface exploration missions to be initiated in 2018. The complexity of the Constellation system of systems and missions will require a communication and navigation infrastructure to provide low and high rate forward and return communication services, tracking services, and ground network services. The infrastructure must provide robust, reliable, safe, sustainable, and autonomous operations at minimum cost while maximizing the exploration capabilities and science return. The infrastructure will be based on a network of networks architecture that will integrate NASA legacy communication, modified elements, and navigation systems. New networks will be added to extend communication, navigation, and timing services for the Moon missions. Internet protocol (IP) and network management systems within the networks will enable interoperability throughout the Constellation system of systems. An integrated network architecture has developed based on the emerging Constellation requirements for Orion missions. The architecture, as presented in this paper, addresses the early Orion missions to the ISS with communication, navigation, and network services over five

  10. Globalization and Landscape Architecture

    Directory of Open Access Journals (Sweden)

    Robert R. Hewitt

    2014-02-01

    Full Text Available The literature review examines globalization and landscape architecture as discourse, samples its various meanings, and proposes methods to identify and contextualize its specific literature. Methodologically, the review surveys published articles and books by leading authors and within the WorldCat.org Database associated with landscape architecture and globalization, analyzing survey results for comprehensive conceptual and co-relational frameworks. Three “higher order” dimensions frame the review’s conceptual organization, facilitating the organization of subordinate/subtopical areas of interest useful for comparative analysis. Comparative analysis of the literature suggests an uneven clustering of discipline-related subject matter across the literature’s “higher order” dimensions, with a much smaller body of literature related to landscape architecture confined primarily to topics associated with the dispersion of global phenomena. A subcomponent of this smaller body of literature is associated with other fields of study, but inferentially related to landscape architecture. The review offers separate references and bibliographies for globalization literature in general and globalization and landscape architecture literature, specifically.

  11. 基于生态伦理的湿地建筑设计理念及方法探究%EXPLORATION OF ARCHITECTURAL DESIGN CONCEPT AND METHOD OF WETLANDS BASED ON ECOLOGICAL ETHICS

    Institute of Scientific and Technical Information of China (English)

    郝赤彪; 杨凯

    2016-01-01

    Taking ecological ethics value orientation as the core and regarding the dynamic evolution process of the relation between man and nature as the theoretical research clues, shape it was moulded the ecological ethics moral values for the mediation of human with nature, man and society, to form new ecological ethics view of nature and the cognition of natural wetland.On this basis to explore the construction properties, comprehensive benefit and feasibility of wetland buildings were explored and it was proposed the design priciples of wetland buildings based on ecological ethics values, which were verified by the engineering practice of the Weishan Lake Wetland water quality observatory station of south-to-north water transfer project.%以生态伦理学价值观取向为核心,以人与自然关系的动态演进过程作为理论研究线索,塑造以自然为中介的人与人、人与社会的生态伦理道德观,从而形成全新的生态伦理自然观和对自然湿地的认知;在此基础上探讨湿地建筑的营建属性、综合效益、可行性,初步构建以生态伦理学价值观引导的湿地建筑营造的设计原则;并结合南水北调微山湖湿地水质观测站项目的工程实践来加以佐证。

  12. Testicular tumors

    Directory of Open Access Journals (Sweden)

    Giovanni Rosti

    2011-12-01

    Full Text Available Germ cell tumors of the testes represent a unique paradigm of diseases which can be cured even in extremely advanced phase. Unfortunately, this makes them unique among adult solid tumors. Seminoma and non seminoma are relatively rare with approximatively 25,000 patients in Europe per year, but numbers are increasing world wide. Different strategies are needed depending on stage and prognostic scores. Seminoma is extremely sensitive to radiation therapy and chemotherapy, while all germ cell tumors show a very good response to chemotherapy. Clinical stage I seminoma is currently treated with radiation, single course carboplatin or surveillance policy. Clinical stage I non seminoma can also be approached with different strategies such as retroperitoneal lymph node dissection, observation or one-two courses of standard chemotherapy. Stage II seminoma may be treated with either radiation or chemotherapy, while for all advanced stages chemotherapy is mandatory. Since the mid-eighties PEB (Cisplatin, Etoposide and Bleomycin is the regimen of choice and no other schedule has proved superior in terms of efficacy. Surgery on the residual disease is crucial to the whole strategy and should be performed or attempted in all cases. Consequently, the correct treatment strategy for these tumors does not depend only on the ability of a single physician, but on a skilled team specialized in this particular tumor. Second line therapies (VeIP, PEI, TIP can cure 25%–40% of patients, but improved strategies for resistant tumors are desperately needed. High-dose chemotherapy has shown very good results in some studies while being less impressive in others. In any case, it should remain an option for relapsing patients and could be used in some cases of upfront chemotherapy in patients with slow marker decline, but this should only be considered in referring centers.

  13. Persian architecture and mathematics

    CERN Document Server

    2012-01-01

    This volulme features eight original papers dedicated to the theme “Persian Architecture and Mathematics,” guest edited by Reza Sarhangi. All papers were approved through a rigorous process of blind peer review and edited by an interdisciplinary scientific editorial committee. Topics range from symmetry in ancient Persian architecture to the elaborate geometric patterns and complex three-dimensional structures of standing monuments of historical periods, from the expression of mathematical ideas to architectonic structures, and from decorative ornament to the representation of modern group theory and quasi-crystalline patterns. The articles discuss unique monuments Persia, including domed structures and two-dimensional patterns, which have received significant scholarly attention in recent years. This book is a unique contribution to studies of Persian architecture in relation to mathematics.

  14. Agent Architectures for Compliance

    Science.gov (United States)

    Burgemeestre, Brigitte; Hulstijn, Joris; Tan, Yao-Hua

    A Normative Multi-Agent System consists of autonomous agents who must comply with social norms. Different kinds of norms make different assumptions about the cognitive architecture of the agents. For example, a principle-based norm assumes that agents can reflect upon the consequences of their actions; a rule-based formulation only assumes that agents can avoid violations. In this paper we present several cognitive agent architectures for self-monitoring and compliance. We show how different assumptions about the cognitive architecture lead to different information needs when assessing compliance. The approach is validated with a case study of horizontal monitoring, an approach to corporate tax auditing recently introduced by the Dutch Customs and Tax Authority.

  15. Ancient Chinese Landscape Architecture

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    IN the past decade,the worldhas suddenly discovered thewonders of Chinese landscapegardening and garden architecture,and places like New York,Singaporeand London have all built Chinese-style gardens.The architectural stylespecial to Chinese gardens has,infact,developed·a“school”of itsown.In China,the landscaped gardenhas long been a part of culture,andliterature,painting,philosophy,cal-ligraphy and folk customs have alldealt with it at one time or another.Two categories of garden architec-ture exist:the imperial garden andthe private garden.The former is,ofcourse,grand and palatial and occu-pies large tracts of land,while the

  16. Architecture of Environmental Engineering

    DEFF Research Database (Denmark)

    Wenzel, Henrik; Alting, Leo

    2006-01-01

    An architecture of Environmental Engineering has been developed comprising the various disciplines and tools involved. It identifies industry as the major actor and target group, and it builds on the concept of Eco-efficiency. To improve Eco-efficiency, there is a limited number of intervention......-efficiency is the aim of Environmental Engineering, the discipline of synthesis – design and creation of solutions – will form a core pillar of the architecture. Other disciplines of Environmental Engineering exist forming the necessary background and frame for the synthesis. Environmental Engineering, thus, in essence...... comprise the disciplines of: management, system description & inventory, analysis & assessment, prioritisation, synthesis, and communication, each existing at all levels of intervention. The developed architecture of Environmental Engineering, thus, consists of thirty individual disciplines, within each...

  17. Architecture of Environmental Engineering

    DEFF Research Database (Denmark)

    Wenzel, Henrik; Alting, Leo

    2004-01-01

    An architecture of Environmental Engineering has been developed comprising the various disciplines and tools involved. It identifies industry as the major actor and target group, and it builds on the concept of Eco-efficiency. To improve Eco-efficiency, there is a limited number of intervention...... of Eco-efficiency is the aim of Environmental Engineering, the discipline of synthesis – design and creation of solutions – will form a core pillar of the architecture. Other disciplines of Environmental Engineering exist forming the necessary background and frame for the synthesis. Environmental...... Engineering, thus, in essence comprise the disciplines of: management, system description & inventory, analysis & assessment, prioritisation, synthesis, and communication, each existing at all levels of intervention. The developed architecture of Environmental Engineering, thus, consists of thirty individual...

  18. Superior sulcus tumors (Pancoast tumors).

    Science.gov (United States)

    Marulli, Giuseppe; Battistella, Lucia; Mammana, Marco; Calabrese, Francesca; Rea, Federico

    2016-06-01

    Superior Sulcus Tumors, frequently termed as Pancoast tumors, are a wide range of tumors invading the apical chest wall. Due to its localization in the apex of the lung, with the potential invasion of the lower part of the brachial plexus, first ribs, vertebrae, subclavian vessels or stellate ganglion, the superior sulcus tumors cause characteristic symptoms, like arm or shoulder pain or Horner's syndrome. The management of superior sulcus tumors has dramatically evolved over the past 50 years. Originally deemed universally fatal, in 1956, Shaw and Paulson introduced a new treatment paradigm with combined radiotherapy and surgery ensuring 5-year survival of approximately 30%. During the 1990s, following the need to improve systemic as well as local control, a trimodality approach including induction concurrent chemoradiotherapy followed by surgical resection was introduced, reaching 5-year survival rates up to 44% and becoming the standard of care. Many efforts have been persecuted, also, to obtain higher complete resection rates using appropriate surgical approaches and involving multidisciplinary team including spine surgeon or vascular surgeon. Other potential treatment options are under consideration like prophylactic cranial irradiation or the addition of other chemotherapy agents or biologic agents to the trimodality approach.

  19. Information architecture. Volume 3: Guidance

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-04-01

    The purpose of this document, as presented in Volume 1, The Foundations, is to assist the Department of Energy (DOE) in developing and promulgating information architecture guidance. This guidance is aimed at increasing the development of information architecture as a Departmentwide management best practice. This document describes departmental information architecture principles and minimum design characteristics for systems and infrastructures within the DOE Information Architecture Conceptual Model, and establishes a Departmentwide standards-based architecture program. The publication of this document fulfills the commitment to address guiding principles, promote standard architectural practices, and provide technical guidance. This document guides the transition from the baseline or defacto Departmental architecture through approved information management program plans and budgets to the future vision architecture. This document also represents another major step toward establishing a well-organized, logical foundation for the DOE information architecture.

  20. Near-Infrared Emission CuInS/ZnS Quantum Dots: All-in-One Theranostic Nanomedicines with Intrinsic Fluorescence/Photoacoustic Imaging for Tumor Phototherapy.

    Science.gov (United States)

    Lv, Guoxian; Guo, Weisheng; Zhang, Wei; Zhang, Tingbin; Li, Shuyi; Chen, Shizhu; Eltahan, Ahmed Shaker; Wang, Dongliang; Wang, Yuqing; Zhang, Jinchao; Wang, Paul C; Chang, Jin; Liang, Xing-Jie

    2016-09-20

    Many theranostic nanomedicines (NMs) have been fabricated by packaging imaging and therapeutic moieties together. However, concerns about their potential architecture instability and pharmacokinetic complexity remain major obstacles to their clinical translation. Herein, we demonstrated the use of CuInS/ZnS quantum dots (ZCIS QDs) as "all-in-one" theranostic nanomedicines that possess intrinsic imaging and therapeutic capabilities within a well-defined nanostructure. ZCIS QDs were exploited for multispectral optical tomography (MSOT) imaging and synergistic PTT/PDT therapy. Due to the intrinsic fluorescence/MSOT imaging ability of the ZCIS QDs, their size-dependent distribution profiles were successfully visualized at tumor sites in vivo. Our results showed that the smaller nanomedicines (ZCIS NMs-25) have longer tumor retention times, higher tumor uptake, and deeper tumor penetration than the larger nanomedicines (ZCIS NMs-80). The ability of ZCIS QDs to mediate photoinduced tumor ablation was also explored. Our results verified that under a single 660 nm laser irradiation, the ZCIS NMs had simultaneous inherent photothermal and photodynamic effects, resulting in high therapy efficacy against tumors. In summary, the ZCIS QDs as "all-in-one" versatile nanomedicines allow high therapeutic efficacy as well as noninvasively monitoring tumor site localization profiles by imaging techniques and thus hold great potential as precision theranostic nanomedicines.

  1. NASA's Lunar Robotic Architecture Study

    Science.gov (United States)

    Mulville, Daniel R.

    2006-07-01

    This report documents the findings and analysis of a 60-day agency-wide Lunar Robotic Architecture Study (LRAS) conducted by the National Aeronautics and Space Administration (NASA). Work on this study began in January 2006. Its purpose was to: Define a lunar robotics architecture by addressing the following issues: 1) Do we need robotic missions at all? If so, why and under what conditions? 2) How would they be accomplished and at what cost? Are they within budget? 3) What are the minimum requirements? What is the minimum mission set? 4) Integrate these elements together to show a viable robotic architecture. 5) Establish a strategic framework for a lunar robotics program. The LRAS Final Report presents analysis and recommendations concerning potential approaches related to NASA s implementation of the President's Vision for Space Exploration. Project and contract requirements will likely be derived in part from the LRAS analysis and recommendations contained herein, but these do not represent a set of project or contract requirements and are not binding on the U.S. Government unless and until they are formally and expressly adopted as such. Details of any recommendations offered by the LRAS Final Report will be translated into implementation requirements. Moreover, the report represents the assessments and projects of the report s authors at the time it was prepared; it is anticipated that the concepts in this report will be analyzed further and refined. By the time some of the activities addressed in this report are implemented, certain assumptions on which the report s conclusions are based will likely evolve as a result of this analysis. Accordingly, NASA, and any entity under contract with NASA, should not use the information in this report for final project direction. Since the conclusion of this study, there have been various changes to the Agency's current portfolio of lunar robotic precursor activities. First, the Robotic Lunar Exploration Program (RLEP

  2. Reframing information architecture

    CERN Document Server

    Resmini, Andrea

    2014-01-01

    Information architecture has changed dramatically since the mid-1990s and earlier conceptions of the world and the internet being different and separate have given way to a much more complex scenario in the present day. In the post-digital world that we now inhabit the digital and the physical blend easily and our activities and usage of information takes place through multiple contexts and via multiple devices and unstable, emergent choreographies. Information architecture now is steadily growing into a channel- or medium-specific multi-disciplinary framework, with contributions coming from a

  3. Architecture as Ars Combinatoria

    OpenAIRE

    Francesco Cacciatore

    2015-01-01

    Architecture today, no longer reflects the limits of experimentation and innovation. An extremely low-tech art whose field of possibilities consists of choosing and using that which has already been done in the past. It is because of this that the key skill a designer should have is the ability to recognize the complexity in forms around them: cities have the widest programming opportunities for architecture, in the two-way relationship that is established from the city that takes form in arc...

  4. IT Service Management Architectures

    DEFF Research Database (Denmark)

    Tambo, Torben; Filtenborg, Jacob

    2017-01-01

    IT service providers tend to view their services as quasi-embedded in the client organisations infrastructure. Therefore, IT service providers lack a full picture of being an organisation with its own enterprise archicture. By systematically developing an enterprise architecture using the unifica......IT service providers tend to view their services as quasi-embedded in the client organisations infrastructure. Therefore, IT service providers lack a full picture of being an organisation with its own enterprise archicture. By systematically developing an enterprise architecture using...

  5. Lunar architecture and urbanism

    Science.gov (United States)

    Sherwood, Brent

    1992-01-01

    Human civilization and architecture have defined each other for over 5000 years on Earth. Even in the novel environment of space, persistent issues of human urbanism will eclipse, within a historically short time, the technical challenges of space settlement that dominate our current view. By adding modern topics in space engineering, planetology, life support, human factors, material invention, and conservation to their already renaissance array of expertise, urban designers can responsibly apply ancient, proven standards to the exciting new opportunities afforded by space. Inescapable facts about the Moon set real boundaries within which tenable lunar urbanism and its component architecture must eventually develop.

  6. Virtual Prototyping and Performance Analysis of Two Memory Architectures

    Directory of Open Access Journals (Sweden)

    Huda S. Muhammad

    2009-01-01

    Full Text Available The gap between CPU and memory speed has always been a critical concern that motivated researchers to study and analyze the performance of memory hierarchical architectures. In the early stages of the design cycle, performance evaluation methodologies can be used to leverage exploration at the architectural level and assist in making early design tradeoffs. In this paper, we use simulation platforms developed using the VisualSim tool to compare the performance of two memory architectures, namely, the Direct Connect architecture of the Opteron, and the Shared Bus of the Xeon multicore processors. Key variations exist between the two memory architectures and both design approaches provide rich platforms that call for the early use of virtual system prototyping and simulation techniques to assess performance at an early stage in the design cycle.

  7. Scalable Multi-core Architectures Design Methodologies and Tools

    CERN Document Server

    Jantsch, Axel

    2012-01-01

    As Moore’s law continues to unfold, two important trends have recently emerged. First, the growth of chip capacity is translated into a corresponding increase of number of cores. Second, the parallalization of the computation and 3D integration technologies lead to distributed memory architectures. This book provides a current snapshot of industrial and academic research, conducted as part of the European FP7 MOSART project, addressing urgent challenges in many-core architectures and application mapping.  It addresses the architectural design of many core chips, memory and data management, power management, design and programming methodologies. It also describes how new techniques have been applied in various industrial case studies. Describes trends towards distributed memory architectures and distributed power management; Integrates Network on Chip with distributed, shared memory architectures; Demonstrates novel design methodologies and frameworks for multi-core design space exploration; Shows how midll...

  8. American School & University Architectural Portfolio 2000 Awards: Landscape Architecture.

    Science.gov (United States)

    American School & University, 2000

    2000-01-01

    Presents photographs and basic information on architectural design, costs, square footage, and principle designers of the award winning school landscaping projects that competed in the American School & University Architectural Portfolio 2000. (GR)

  9. The Architectural Information Map: Semantic modeling in conceptual architectural design

    NARCIS (Netherlands)

    Tunçer, E.B.

    2009-01-01

    This research focuses on the acquisition, representation, sharing and reuse of design information and knowledge in the conceptual phase of architectural design, and targets the creation of situated digital environments where communities of architectural practice communicate and collaborate using thi

  10. Discrete optimization in architecture architectural & urban layout

    CERN Document Server

    Zawidzki, Machi

    2016-01-01

    This book presents three projects that demonstrate the fundamental problems of architectural design and urban composition – the layout design, evaluation and optimization. Part I describes the functional layout design of a residential building, and an evaluation of the quality of a town square (plaza). The algorithm for the functional layout design is based on backtracking using a constraint satisfaction approach combined with coarse grid discretization. The algorithm for the town square evaluation is based on geometrical properties derived directly from its plan. Part II introduces a crowd-simulation application for the analysis of escape routes on floor plans, and optimization of a floor plan for smooth crowd flow. The algorithms presented employ agent-based modeling and cellular automata.

  11. Medical Data Architecture Project Status

    Science.gov (United States)

    Krihak, M.; Middour, C.; Lindsey, A.; Marker, N.; Wolfe, S.; Winther, S.; Ronzano, K.; Bolles, D.; Toscano, W.; Shaw, T.

    2017-01-01

    The Medical Data Architecture (MDA) project supports the Exploration Medical Capability (ExMC) risk to minimize or reduce the risk of adverse health outcomes and decrements in performance due to in-flight medical capabilities on human exploration missions. To mitigate this risk, the ExMC MDA project addresses the technical limitations identified in ExMC Gap Med 07: We do not have the capability to comprehensively process medically-relevant information to support medical operations during exploration missions. This gap identifies that the current International Space Station (ISS) medical data management includes a combination of data collection and distribution methods that are minimally integrated with on-board medical devices and systems. Furthermore, there are variety of data sources and methods of data collection. For an exploration mission, the seamless management of such data will enable an increasingly autonomous crew than the current ISS paradigm. The MDA will develop capabilities that support automated data collection, and the necessary functionality and challenges in executing a self-contained medical system that approaches crew health care delivery without assistance from ground support. To attain this goal, the first year of the MDA project focused on reducing technical risk, developing documentation and instituting iterative development processes that established the basis for the first version of MDA software (or Test Bed 1). Test Bed 1 is based on a nominal operations scenario authored by the ExMC Element Scientist. This narrative was decomposed into a Concept of Operations that formed the basis for Test Bed 1 requirements. These requirements were successfully vetted through the MDA Test Bed 1 System Requirements Review, which permitted the MDA project to begin software code development and component integration. This paper highlights the MDA objectives, development processes, and accomplishments, and identifies the fiscal year 2017 milestones and

  12. AES Water Architecture Study Interim Results

    Science.gov (United States)

    Sarguisingh, Miriam J.

    2012-01-01

    The mission of the Advanced Exploration System (AES) Water Recovery Project (WRP) is to develop advanced water recovery systems in order to enable NASA human exploration missions beyond low earth orbit (LEO). The primary objective of the AES WRP is to develop water recovery technologies critical to near term missions beyond LEO. The secondary objective is to continue to advance mid-readiness level technologies to support future NASA missions. An effort is being undertaken to establish the architecture for the AES Water Recovery System (WRS) that meets both near and long term objectives. The resultant architecture will be used to guide future technical planning, establish a baseline development roadmap for technology infusion, and establish baseline assumptions for integrated ground and on-orbit environmental control and life support systems (ECLSS) definition. This study is being performed in three phases. Phase I of this study established the scope of the study through definition of the mission requirements and constraints, as well as indentifying all possible WRS configurations that meet the mission requirements. Phase II of this study focused on the near term space exploration objectives by establishing an ISS-derived reference schematic for long-duration (>180 day) in-space habitation. Phase III will focus on the long term space exploration objectives, trading the viable WRS configurations identified in Phase I to identify the ideal exploration WRS. The results of Phases I and II are discussed in this paper.

  13. Transformation of Minarets in Contemporary Mosque Architecture in Turkey

    OpenAIRE

    Urey, Ozgur

    2014-01-01

    This study aims to explore the usage, the formal and functional transformation of minarets in contemporary mosque architecture in Turkey, through a survey of the selected cases. The selected cases are the outstanding examples of Turkish contemporary mosque architecture. Their architects are innovative in their design decisions and displayed their own design approach and interpretation outside the main stream contemporary mosque design in Turkey. In this study, six mosques for every decade beg...

  14. Transformation of Minarets in Contemporary Mosque Architecture in Turkey

    OpenAIRE

    Urey, Ozgur

    2013-01-01

    This study aims to explore the usage, the formal and functional transformation of minarets in contemporary mosque architecture in Turkey, through a survey of the selected cases. The selected cases are the outstanding examples of Turkish contemporary mosque architecture. Their architects are innovative in their design decisions and displayed their own design approach and interpretation outside the main stream contemporary mosque design in Turkey. In this study, six mosques for every decade beg...

  15. Cartography of Architectural Controversies

    DEFF Research Database (Denmark)

    Lotz, Katrine

    2010-01-01

    or the office. The paper consists of investigations into such a stance. It is based on empiric studies, readings in architectural theory and applied actor-network theory. Furthermore the paper draws on recent examples of teaching practices pursuing this theme at the Royal Academy of Fine Arts, School...

  16. Cartography of architectural controversies

    DEFF Research Database (Denmark)

    Lotz, Katrine

    2009-01-01

    that employing the visualising methods of the recent development of Actor-Network-Theory called ‘Cartography of Controversies' might contribute to trans-disciplinary efforts to develop analytic understanding of the conflicting human purposes and power-struggles at stake in the be-coming of architecture....

  17. Principles of landscape architecture

    NARCIS (Netherlands)

    Nijhuis, S.

    2013-01-01

    The Department of Urbanism at the Faculty of Architecture and Built Environment, TU Delft considers urbanism as a planning and design oriented activity towards urban and rural landscapes. It aims to enhance, restore or create landscapes from a perspective of sustainable development, so as to guide,

  18. IT Service Management Architectures

    DEFF Research Database (Denmark)

    Tambo, Torben; Filtenborg, Jacob

    2017-01-01

    IT service providers tend to view their services as quasi-embedded in the client organisations infrastructure. Therefore, IT service providers lack a full picture of being an organisation with its own enterprise archicture. By systematically developing an enterprise architecture using...

  19. Robustness via Diffractal Architectures

    CERN Document Server

    Moocarme, Matthew

    2015-01-01

    When plane waves diffract through fractal-patterned apertures, the resulting far-field profiles or diffractals also exhibit iterated, self-similar features. Here we show that this specific architecture enables robust signal processing and spatial multiplexing: arbitrary parts of a diffractal contain sufficient information to recreate the entire original sparse signal.

  20. Architecture and Nature

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Chinese-American architect Maya Lin has become renowned by people in China recently because of her latest work-"What is Missing?" The multi-site project aims to raise public awareness of the current crisis surrounding biodiversity and habitat loss. Lin recently talked about the project’s background and her understanding of the relation between architecture and nature with Beijing Review.

  1. Enriching software architecture documentation

    NARCIS (Netherlands)

    Jansen, Anton; Avgeriou, Paris; Ven, Jan Salvador van der

    2009-01-01

    The effective documentation of Architectural Knowledge (AK) is one of the key factors in leveraging the paradigm shift toward sharing and reusing AK. However, current documentation approaches have severe shortcomings in capturing the knowledge of large and complex systems and subsequently facilitati

  2. Paper relief architecture

    NARCIS (Netherlands)

    Latka, J.F.

    2014-01-01

    The article presents two contemporary projects of paper structures relief architecture designed and built by Shigeru Ban Architects and Voluntary Architect Network. Author of the article took part in design and construction process of one of the projects. The project of Yaan Nursery School, which wa

  3. Evolution Through Architectural Reconciliation

    NARCIS (Netherlands)

    Avgeriou, Paris; Guelfi, Nicolas; Perrouin, Gilles

    2005-01-01

    One of the possible scenarios in a system evolution cycle, is to translate an emergent set of new requirements into software architecture design and subsequently to update the system implementation. In this paper, we argue that this form of forward engineering, even though addresses the new system r

  4. The toolbus coordination architecture

    NARCIS (Netherlands)

    Bergstra, J.A.; Klint, P.

    1996-01-01

    Building large, heterogeneous, distributed software systems poses serious problems for the software engineer; achieving interoperability of software systems is still a major challenge. We describe an experiment in designing a generic software architecture for solving these problems. To get control o

  5. Architectural Creation of Light

    DEFF Research Database (Denmark)

    Bülow, Katja

    2015-01-01

    Bidraget "Architectural Creation of Light" indgår sammen med 108 andre bidrag i bogen "You Say Light, I Think Shadow". Bogens indhold undersøger: "Hvad er lys". I dette bidrag besvares spørgsmålet gennem iagttagelser af arkitektstuderendes undersøgelser af lyset i deres arbejdsmodeller i...

  6. Interactive Architecture #1

    NARCIS (Netherlands)

    Oosterhuis, K.; Xia, X.

    2007-01-01

    The iA bookzine series will consist of twelve issues, bi-annually published over a period of six years under the supervision of Prof. ir. Kas Oosterhuis, director of the Hperbody at the Delft University of Technology. Interactive Architecture - from here on abbreviated as iA - is NOT simply archite

  7. Architectural Guide of Jordan

    DEFF Research Database (Denmark)

    Hilberth, Thomas Roger

    2016-01-01

    Architectural and cultural guidebook for Jordan that also includes a view on the Syrian refugee situation, especially in the large UNHCR camp of Zaatari. The guide book is a preparatory study for a field trip our master studio undertook to the Hashemite Kingdom of Jordan in Fall 2016....

  8. Smart Grid Architectures

    DEFF Research Database (Denmark)

    Dondossola, Giovanna; Terruggia, Roberta; Bessler, Sandford

    2014-01-01

    The scope of this paper is to address the evolution of distribution grid architectures following the widespread introduction of renewable energy sources. The increasing connection of distributed resources has a strong impact on the topology and the control functionality of the current distributio...

  9. Future Network Architectures

    DEFF Research Database (Denmark)

    Wessing, Henrik; Bozorgebrahimi, Kurosh; Belter, Bartosz;

    2015-01-01

    This study identifies key requirements for NRENs towards future network architectures that become apparent as users become more mobile and have increased expectations in terms of availability of data. In addition, cost saving requirements call for federated use of, in particular, the optical spec...

  10. Tutorial on architectural acoustics

    Science.gov (United States)

    Shaw, Neil; Talaske, Rick; Bistafa, Sylvio

    2002-11-01

    This tutorial is intended to provide an overview of current knowledge and practice in architectural acoustics. Topics covered will include basic concepts and history, acoustics of small rooms (small rooms for speech such as classrooms and meeting rooms, music studios, small critical listening spaces such as home theatres) and the acoustics of large rooms (larger assembly halls, auditoria, and performance halls).

  11. [Architecture and movement].

    Science.gov (United States)

    Rivallan, Armel

    2012-01-01

    Leading an architectural project means accompanying the movement which it induces within the teams. Between questioning, uncertainty and fear, the organisational changes inherent to the new facility must be subject to constructive and ongoing exchanges. Ethics, safety and training are revised and the unit projects are sometimes modified.

  12. [Architecture, budget and dignity].

    Science.gov (United States)

    Morel, Etienne

    2012-01-01

    Drawing on its dynamic strengths, a psychiatric unit develops various projects and care techniques. In this framework, the institute director must make a number of choices with regard to architecture. Why renovate the psychiatry building? What financial investments are required? What criteria should be followed? What if the major argument was based on the respect of the patient's dignity?

  13. Enterprise Architecture Evaluation

    DEFF Research Database (Denmark)

    Andersen, Peter; Carugati, Andrea

    2014-01-01

    By being holistically preoccupied with coherency among organizational elements such as organizational strategy, business needs and the IT functions role in supporting the business, enterprise architecture (EA) has grown to become a core competitive advantage. Though EA is a maturing research area...

  14. EMI Security Architecture

    CERN Document Server

    White, J.; Schuller, B.; Qiang, W.; Groep, D.; Koeroo, O.; Salle, M.; Sustr, Z.; Kouril, D.; Millar, P.; Benedyczak, K.; Ceccanti, A.; Leinen, S.; Tschopp, V.; Fuhrmann, P.; Heyman, E.; Konstantinov, A.

    2013-01-01

    This document describes the various architectures of the three middlewares that comprise the EMI software stack. It also outlines the common efforts in the security area that allow interoperability between these middlewares. The assessment of the EMI Security presented in this document was performed internally by members of the Security Area of the EMI project.

  15. Terra Harvest software architecture

    Science.gov (United States)

    Humeniuk, Dave; Klawon, Kevin

    2012-06-01

    Under the Terra Harvest Program, the DIA has the objective of developing a universal Controller for the Unattended Ground Sensor (UGS) community. The mission is to define, implement, and thoroughly document an open architecture that universally supports UGS missions, integrating disparate systems, peripherals, etc. The Controller's inherent interoperability with numerous systems enables the integration of both legacy and future UGS System (UGSS) components, while the design's open architecture supports rapid third-party development to ensure operational readiness. The successful accomplishment of these objectives by the program's Phase 3b contractors is demonstrated via integration of the companies' respective plug-'n'-play contributions that include controllers, various peripherals, such as sensors, cameras, etc., and their associated software drivers. In order to independently validate the Terra Harvest architecture, L-3 Nova Engineering, along with its partner, the University of Dayton Research Institute, is developing the Terra Harvest Open Source Environment (THOSE), a Java Virtual Machine (JVM) running on an embedded Linux Operating System. The Use Cases on which the software is developed support the full range of UGS operational scenarios such as remote sensor triggering, image capture, and data exfiltration. The Team is additionally developing an ARM microprocessor-based evaluation platform that is both energy-efficient and operationally flexible. The paper describes the overall THOSE architecture, as well as the design decisions for some of the key software components. Development process for THOSE is discussed as well.

  16. Effect of Ceramic Scaffold Architectural Parameters on Biological Response

    Directory of Open Access Journals (Sweden)

    Maria Isabella eGariboldi

    2015-10-01

    Full Text Available Numerous studies have focused on the optimization of ceramic architectures to fulfill a variety of scaffold functional requirements and improve biological response. Conventional fabrication techniques, however, do not allow for the production of geometrically controlled, reproducible structures and often fail to allow the independent variation of individual geometric parameters. Current developments in additive manufacturing technologies suggest that 3D printing will allow a more controlled and systematic exploration of scaffold architectures. This more direct translation of design into structure requires a pipeline for design-driven optimization. A theoretical framework for systematic design and evaluation of architectural parameters on biological response is presented. Four levels of architecture are considered, namely (1 surface topography, (2 pore size and geometry, (3 porous networks and (4 macroscopic pore arrangement, including the potential for spatially varied architectures. Studies exploring the effect of various parameters within these levels are reviewed. This framework will hopefully allow uncovering of new relationships between architecture and biological response in a more systematic way, as well as inform future refinement of fabrication techniques to fulfill architectural necessities with a consideration of biological implications.

  17. Effect of Ceramic Scaffold Architectural Parameters on Biological Response.

    Science.gov (United States)

    Gariboldi, Maria Isabella; Best, Serena M

    2015-01-01

    Numerous studies have focused on the optimization of ceramic architectures to fulfill a variety of scaffold functional requirements and improve biological response. Conventional fabrication techniques, however, do not allow for the production of geometrically controlled, reproducible structures and often fail to allow the independent variation of individual geometric parameters. Current developments in additive manufacturing technologies suggest that 3D printing will allow a more controlled and systematic exploration of scaffold architectures. This more direct translation of design into structure requires a pipeline for design-driven optimization. A theoretical framework for systematic design and evaluation of architectural parameters on biological response is presented. Four levels of architecture are considered, namely (1) surface topography, (2) pore size and geometry, (3) porous networks, and (4) macroscopic pore arrangement, including the potential for spatially varied architectures. Studies exploring the effect of various parameters within these levels are reviewed. This framework will hopefully allow uncovering of new relationships between architecture and biological response in a more systematic way as well as inform future refinement of fabrication techniques to fulfill architectural necessities with a consideration of biological implications.

  18. Space Mobile Network: A Near Earth Communication and Navigation Architecture

    Science.gov (United States)

    Israel, Dave J.; Heckler, Greg; Menrad, Robert J.

    2016-01-01

    This paper describes a Space Mobile Network architecture, the result of a recently completed NASA study exploring architectural concepts to produce a vision for the future Near Earth communications and navigation systems. The Space Mobile Network (SMN) incorporates technologies, such as Disruption Tolerant Networking (DTN) and optical communications, and new operations concepts, such as User Initiated Services, to provide user services analogous to a terrestrial smartphone user. The paper will describe the SMN Architecture, envisioned future operations concepts, opportunities for industry and international collaboration and interoperability, and technology development areas and goals.

  19. An Experiment in Architectural Instruction.

    Science.gov (United States)

    Dvorak, Robert W.

    1978-01-01

    Discusses the application of the PLATO IV computer-based educational system to a one-semester basic drawing course for freshman architecture, landscape architecture, and interior design students and relates student reactions to the experience. (RAO)

  20. Evolutionary design assistants for architecture

    Directory of Open Access Journals (Sweden)

    N. Onur Sönmez

    2015-04-01

    Full Text Available In its parallel pursuit of an increased competitivity for design offices and more pleasurable and easier workflows for designers, artificial design intelligence is a technical, intellectual, and political challenge. While human-machine cooperation has become commonplace through Computer Aided Design (CAD tools, a more improved collaboration and better support appear possible only through an endeavor into a kind of artificial design intelligence, which is more sensitive to the human perception of affairs.Considered as part of the broader Computational Design studies, the research program of this quest can be called Artificial / Autonomous / Automated Design (AD. The current available level of Artificial Intelligence (AI for design is limited and a viable aim for current AD would be to develop design assistants that are capable of producing drafts for various design tasks. Thus, the overall aim of this thesis is the development of approaches, techniques, and tools towards artificial design assistants that offer a capability for generating drafts for sub-tasks within design processes. The main technology explored for this aim is Evolutionary Computation (EC, and the target design domain is architecture. The two connected research questions of the study concern, first, the investigation of the ways to develop an architectural design assistant, and secondly, the utilization of EC for the development of such assistants.While developing approaches, techniques, and computational tools for such an assistant, the study also carries out a broad theoretical investigation into the main problems, challenges, and requirements towards such assistants on a rather overall level. Therefore, the research is shaped as a parallel investigation of three main threads interwoven along several levels, moving from a more general level to specific applications. The three research threads comprise, first, theoretical discussions and speculations with regard to both existing

  1. Tumor thrombus

    DEFF Research Database (Denmark)

    Ravina, Mudalsha; Hess, Søren; Chauhan, Mahesh Singh;

    2014-01-01

    PURPOSE: Thrombosis in cancer may manifest itself as venous thromboembolic disease or tumor thrombosis (TT). We present our experience with incidentally detected TT on FDG PET/CT in 21 oncologic patients. PATIENTS AND METHODS: We retrospectively reviewed all FDG PET/CT examinations during a 5-year......-one patients were included; the most common malignancies were renal cell carcinoma (n=6), hepatocellular carcinoma (n=3), and lung cancer (n=3). Indication for the scan was initial staging (n=15) and suspected recurrence (n=6). Several vessels were affected, the most common was the inferior vena cava (n=14......), but most other major branches of the venous vasculature was represented, and some patients had thrombi in several vessels. FDG uptake was linear in 7 patients, linear with a dilated vessel in 6 patients, and focal in 7 patients. The mean SUVmax of the primary tumors was 10.3 (range, 2.6-31.2; median, 6...

  2. Islamic Values in Spatial Function of Javanese Traditional Architecture

    Directory of Open Access Journals (Sweden)

    Supriyanta Supriyanta

    2016-01-01

    Full Text Available Learn from the past is important thing as based for the next step. Learn past architecture to gain positive values can be used as guidelines to design better architectural works. Javanese traditional architecture is one of local architecture from the past which has positive values, even if it is done deeper study; it has Islamic values which can be used as principles in the process of Islamic architectural design. To achieve Islamic values in spatial pattern Javanese traditional architecture can be done through exploration and reviewing Javanese traditional architectural space afterward it is associated with Islamic values which are relevant with Al Qur’an and sunnah prophet. In fact is the spatial pattern in Javanese traditional architecture arrayed with beauty and also has Islamic valuable function. Those Islamic values are 1 high esteem guest (pendopo through providing wide and comfortable living room; 2 create divider (pringgitan which separate between living room and main room so that the privation can be kept; 3 separation the bed room (gandok kiwo and gandok tengen between parents and their children who are going mature and also between boys and girls; 4 provide praying room (senthong tengah to pray as family education and also as a place to pray to the God.

  3. Enterprise architecture for business success

    CERN Document Server

    Wijegunaratne, Inji; Evans-Greenwood, Peter

    2014-01-01

    Enterprise Architecture (EA) has evolved to become a prominent presence in today's information systems and technology landscape. The EA discipline is rich in frameworks, methodologies, and the like. However, the question of 'value' for business ;professionals remains largely unanswered - that is, how best can Enterprise Architecture and Enterprise Architects deliver value to the enterprise? Enterprise Architecture for Business Success answers this question. Enterprise Architecture for Business Success is primarily intended for IT professionals working in the area of Enterprise Architectu

  4. Economics-driven software architecture

    CERN Document Server

    Mistrik, Ivan; Kazman, Rick; Zhang, Yuanyuan

    2014-01-01

    Economics-driven Software Architecture presents a guide for engineers and architects who need to understand the economic impact of architecture design decisions: the long term and strategic viability, cost-effectiveness, and sustainability of applications and systems. Economics-driven software development can increase quality, productivity, and profitability, but comprehensive knowledge is needed to understand the architectural challenges involved in dealing with the development of large, architecturally challenging systems in an economic way. This book covers how to apply economic consider

  5. Architectural Design Activities for JAS

    CERN Document Server

    Khaled, Lena

    2009-01-01

    The critical part for building any software system is its architecture. Architectural design is a design at a higher level of abstraction. A good architecture ensures that software will satisfy its requirement. This paper defines the most important activities of architectural design that used through building any software; also it applies these activities on one type of Electronic Commerce (EC) applications that is Job Agency System(JAS) to show how these activities can work through these types of applications.

  6. Architectural engineering of FRP bridges

    OpenAIRE

    Smits, J.E.P.

    2014-01-01

    This paper deals with the use of Fibre Reinforced Polymers (FRP's) in architectural and structural bridge design. The challenges and opportunities that come with this relatively new material are discussed. An inventory is made of recent engineers' solutions in FRP, followed by a discussion on architectural application of FRP's derived from the authors architectural practice.

  7. Synthesis - Based Software Architecture Design

    NARCIS (Netherlands)

    Tekinerdogan, Bedir; Aksit, Mehmet; Akşit, Mehmet

    2001-01-01

    During the last decade several architecture design approaches have been introduced. These approaches however have to cope with several obstacles and software architecture design remains a difficult problem. To cope with these obstacles this chapter introduces a novel architecture design approach. Th

  8. Meet French Architecture in China

    Institute of Scientific and Technical Information of China (English)

    Susan

    2005-01-01

    On April 5, a French architectural exhibition entitled ""French Visions: City, Architecture and Sustainable Development"" was unveiled in Beijing Urban Planning Center. As a key exhibition within the framework of French Year in China, the exhibition will also be displayed in Shanghai and Chongqing. The largest exhibition of its kind ever held in China, French Visions extensively showed accomplishments of contemporary French architectural design.

  9. Software Architecture Description and UML

    NARCIS (Netherlands)

    Avgeriou, Paris; Guelfi, Nicolas; Medvidovic, Nenad

    2005-01-01

    The description of software architectures has always been concerned with the definition of the appropriate languages for designing the various architectural artifacts. Over the past ten years, formal or less formal Architecture Description Languages (ADLs) and supporting methods and tools have been

  10. Microvascular changes in AT17-tumors of mouse during radiotherapy

    CERN Document Server

    Seidl, S

    2000-01-01

    responsible for rising permeability, which contradicts the former hypothesis of leaky vessels caused by apoptosis. Large radiation doses damage tumor cells and blood vessels and cause growth reduction and regression. Tumors exceeding in size 1-2 mm require nutrition by blood vessels for tumor survival. We aimed to record changes in architecture, structure and function of tumor vascularisation after radiation. 12 AT17-mammary-adenocarcinomas of mouse were examined before and immediately after fractionated radiotherapy total dose 42 or 78 Gray. Double intravital perfusion (20 min interval) with fluorochrome-conjugated lectin (HPA-TRITC, HPA-FITC) was used to mark all perfused vessels. Cryostat sections of the tumors were viewed by a laser-scanning-microscope and 2-channel-images shown as mismatch-mosaics. Due to this technique, with labeling lasting 4 hours, it was possible to confirm intermittent perfusion, describe complete microvessel architecture and make statements about endothelial cell function. After 42...

  11. Brain tumor - children

    Science.gov (United States)

    ... children; Neuroglioma - children; Oligodendroglioma - children; Meningioma - children; Cancer - brain tumor (children) ... The cause of primary brain tumors is unknown. Primary brain tumors may ... (spread to nearby areas) Cancerous (malignant) Brain tumors ...

  12. Adrenal Gland Tumors: Statistics

    Science.gov (United States)

    ... Gland Tumor: Statistics Request Permissions Adrenal Gland Tumor: Statistics Approved by the Cancer.Net Editorial Board , 03/ ... primary adrenal gland tumor is very uncommon. Exact statistics are not available for this type of tumor ...

  13. Understanding Brain Tumors

    Science.gov (United States)

    ... to Know About Brain Tumors . What is a Brain Tumor? A brain tumor is an abnormal growth
 ... Tumors” from Frankly Speaking Frankly Speaking About Cancer: Brain Tumors Download the full book Questions to ask ...

  14. Brain tumor - primary - adults

    Science.gov (United States)

    ... Vestibular schwannoma (acoustic neuroma) - adults; Meningioma - adults; Cancer - brain tumor (adults) ... Primary brain tumors include any tumor that starts in the brain. Primary brain tumors can start from brain cells, ...

  15. Architecture Descriptions. A Contribution to Modeling of Production System Architecture

    DEFF Research Database (Denmark)

    Jepsen, Allan Dam; Hvam, Lars

    on the underlying principles of a production system’s design; and despite the existence of established architecture and platform theories and practices within product design, there is still a need for a better understanding of the architecture phenomenon itself, and certainly how it applies within production system....... The viewpoints provide a set of model kinds to frame select architecture related concerns relating to the production capability and the design of the technical system. With the contribution to architecture description there follows a need to support exchange and processing of architecture information within......The subject of this PhD dissertation is architecture-centric design and the description of production system architecture. Companies are facing demands for the development and production of new products at an ever increasing rate, as the market life of products decreases and the rate at which...

  16. Exploration Geophysics

    Science.gov (United States)

    Savit, Carl H.

    1978-01-01

    Expansion of activity and confirmation of new technological directions characterized several fields of exploration geophysics in 1977. Advances in seismic-reflection exploration have been especially important. (Author/MA)

  17. Exploration Review

    Science.gov (United States)

    Wilburn, D.R.; Stanley, K.A.

    2013-01-01

    This summary of international mineral exploration activities for 2012 draws upon information from industry sources, published literature and U.S. Geological Survey (USGS) specialists. The summary provides data on exploration budgets by region and mineral commodity, identifies significant mineral discoveries and areas of mineral exploration, discusses government programs affecting the mineral exploration industry and presents analyses of exploration activities performed by the mineral industry. Three sources of information are reported and analyzed in this annual review of international exploration for 2012: 1) budgetary statistics expressed in U.S. nominal dollars provided by SNL Metals Economics Group (MEG) of Halifax, Nova Scotia; 2) regional and site-specific exploration activities that took place in 2012 as compiled by the USGS and 3) regional events including economic, social and political conditions that affected exploration activities, which were derived from published sources and unpublished discussions with USGS and industry specialists.

  18. Exploration technology

    Energy Technology Data Exchange (ETDEWEB)

    Roennevik, H.C. [Saga Petroleum A/S, Forus (Norway)

    1996-12-31

    The paper evaluates exploration technology. Topics discussed are: Visions; the subsurface challenge; the creative tension; the exploration process; seismic; geology; organic geochemistry; seismic resolution; integration; drilling; value creation. 4 refs., 22 figs.

  19. Pediatric brain tumors

    Energy Technology Data Exchange (ETDEWEB)

    Poussaint, Tina Y. [Department of Radiology, Boston, MA (United States); Panigrahy, Ashok [Children' s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Department of Radiology, Pittsburgh, PA (United States); Huisman, Thierry A.G.M. [Charlotte R. Bloomberg Children' s Center, Johns Hopkins Hospital, Division of Pediatric Radiology and Pediatric Neuroradiology, Baltimore, MD (United States)

    2015-09-15

    Among all causes of death in children from solid tumors, pediatric brain tumors are the most common. This article includes an overview of a subset of infratentorial and supratentorial tumors with a focus on tumor imaging features and molecular advances and treatments of these tumors. Key to understanding the imaging features of brain tumors is a firm grasp of other disease processes that can mimic tumor on imaging. We also review imaging features of a common subset of tumor mimics. (orig.)

  20. Geometric Rationalization for Freeform Architecture

    KAUST Repository

    Jiang, Caigui

    2016-06-20

    The emergence of freeform architecture provides interesting geometric challenges with regards to the design and manufacturing of large-scale structures. To design these architectural structures, we have to consider two types of constraints. First, aesthetic constraints are important because the buildings have to be visually impressive. Sec- ond, functional constraints are important for the performance of a building and its e cient construction. This thesis contributes to the area of architectural geometry. Specifically, we are interested in the geometric rationalization of freeform architec- ture with the goal of combining aesthetic and functional constraints and construction requirements. Aesthetic requirements typically come from designers and architects. To obtain visually pleasing structures, they favor smoothness of the building shape, but also smoothness of the visible patterns on the surface. Functional requirements typically come from the engineers involved in the construction process. For exam- ple, covering freeform structures using planar panels is much cheaper than using non-planar ones. Further, constructed buildings have to be stable and should not collapse. In this thesis, we explore the geometric rationalization of freeform archi- tecture using four specific example problems inspired by real life applications. We achieve our results by developing optimization algorithms and a theoretical study of the underlying geometrical structure of the problems. The four example problems are the following: (1) The design of shading and lighting systems which are torsion-free structures with planar beams based on quad meshes. They satisfy the functionality requirements of preventing light from going inside a building as shad- ing systems or reflecting light into a building as lighting systems. (2) The Design of freeform honeycomb structures that are constructed based on hex-dominant meshes with a planar beam mounted along each edge. The beams intersect without

  1. CisLunar Habitat Internal Architecture Design Criteria

    Science.gov (United States)

    Jones, R.; Kennedy, K.; Howard, R.; Whitmore, M.; Martin, C.; Garate, J.

    2017-01-01

    BACKGROUND: In preparation for human exploration to Mars, there is a need to define the development and test program that will validate deep space operations and systems. In that context, a Proving Grounds CisLunar habitat spacecraft is being defined as the next step towards this goal. This spacecraft will operate differently from the ISS or other spacecraft in human history. The performance envelope of this spacecraft (mass, volume, power, specifications, etc.) is being defined by the Future Capabilities Study Team. This team has recognized the need for a human-centered approach for the internal architecture of this spacecraft and has commissioned a CisLunar Phase-1 Habitat Internal Architecture Study Team to develop a NASA reference configuration, providing the Agency with a "smart buyer" approach for future acquisition. THE CISLUNAR HABITAT INTERNAL ARCHITECTURE STUDY: Overall, the CisLunar Habitat Internal Architecture study will address the most significant questions and risks in the current CisLunar architecture, habitation, and operations concept development. This effort is achieved through definition of design criteria, evaluation criteria and process, design of the CisLunar Habitat Phase-1 internal architecture, and the development and fabrication of internal architecture concepts combined with rigorous and methodical Human-in-the-Loop (HITL) evaluations and testing of the conceptual innovations in a controlled test environment. The vision of the CisLunar Habitat Internal Architecture Study is to design, build, and test a CisLunar Phase-1 Habitat Internal Architecture that will be used for habitation (e.g. habitability and human factors) evaluations. The evaluations will mature CisLunar habitat evaluation tools, guidelines, and standards, and will interface with other projects such as the Advanced Exploration Systems (AES) Program integrated Power, Avionics, Software (iPAS), and Logistics for integrated human-in-the-loop testing. The mission of the Cis

  2. Architecture and communication

    Directory of Open Access Journals (Sweden)

    Špela Hudnik

    2003-01-01

    Full Text Available The article presents effects of technology, science and capital strategies on changes in traditional forms and definitions of space, architecture and bodies. It confronts us with new processes of thinking and living that are constantly being transformed into new dynamic time and spatial contexts. Space is becoming the information filter, communication network. A cross-section of three landscapes: landscape of megastructures, nomadic landscapes and psychedelic landscapes, theory contributes to understanding of media and space-age technology, information technology and electronical language. It offers designs of various megastructures, media surfaces and envelopes of contemporary information society: the anthropological module, hyper- and infra-bodies, bio-electronical bodies and population genetics bodies. It presents the architecture of communication.

  3. Visual expression in architecture

    Directory of Open Access Journals (Sweden)

    Alfirević Đorđe

    2011-01-01

    Full Text Available Relaying on standpoints of the renowned art critic Herbert Read, according to which realism, idealism and expressionism are not separate art movements, but represent permanent basic factors in all arts, this paper considers the possibility of existence of elementary creative orientation in architecture as well. Starting from basic aspects of perception and representation of the world around us, and through a comparative analysis and examples from other fields, a thesis is presented according to which notions of mimesis (mimicry, associativity and expression in architecture are adequate counterparts to Read's basic factors of art - realism, idealism and expressionism. Depending on sociopolitical, cultural and historical, as well as other circumstances, from time to time some of these factors come to the surface, wrapped up in time, and emerge in some new or old form which we can recognize as an art movement or style.

  4. Art and Architectural Space

    DEFF Research Database (Denmark)

    Unterrainer, Walter

    2014-01-01

    art and architectural space museums and other exhibition spaces or how artists learn to love architects Over the last two decades, innumerable new museums, art galleries and other exhibition spaces have been built and opened all over the globe. The most extreme growth happened in China, where...... historically considered even the mother of all arts) - but more relevant: what are appropriate architectural spaces for presenting, exhibiting, contemplating, reflecting, meditating, discussing, enjoying, dissenting, debating creations of art. Simplified, this is a question about the relation between package...... and its content. The urban and spatial question goes far beyond museums and other buildings for art: how in democratic societies should public spaces be supported by art and how can public art support ´cityness´ and meaning versus spaces of consumerism. Famous but egocentric buildings with the main...

  5. Heterogeneous network architectures

    DEFF Research Database (Denmark)

    Christiansen, Henrik Lehrmann

    2006-01-01

    Future networks will be heterogeneous! Due to the sheer size of networks (e.g., the Internet) upgrades cannot be instantaneous and thus heterogeneity appears. This means that instead of trying to find the olution, networks hould be designed as being heterogeneous. One of the key equirements here...... is flexibility. This thesis investigates such heterogeneous network architectures and how to make them flexible. A survey of algorithms for network design is presented, and it is described how using heuristics can increase the speed. A hierarchical, MPLS based network architecture is described...... and it is discussed that it is advantageous to heterogeneous networks and illustrated by a number of examples. Modeling and simulation is a well-known way of doing performance evaluation. An approach to event-driven simulation of communication networks is presented and mixed complexity modeling, which can simplify...

  6. Consistent model driven architecture

    Science.gov (United States)

    Niepostyn, Stanisław J.

    2015-09-01

    The goal of the MDA is to produce software systems from abstract models in a way where human interaction is restricted to a minimum. These abstract models are based on the UML language. However, the semantics of UML models is defined in a natural language. Subsequently the verification of consistency of these diagrams is needed in order to identify errors in requirements at the early stage of the development process. The verification of consistency is difficult due to a semi-formal nature of UML diagrams. We propose automatic verification of consistency of the series of UML diagrams originating from abstract models implemented with our consistency rules. This Consistent Model Driven Architecture approach enables us to generate automatically complete workflow applications from consistent and complete models developed from abstract models (e.g. Business Context Diagram). Therefore, our method can be used to check practicability (feasibility) of software architecture models.

  7. Architecture and Energy

    DEFF Research Database (Denmark)

    Lauring, Michael; Marsh, Rob

    2009-01-01

    Architecture and Energy. Strategies for a Changing Climate. By Michael Lauring and Rob Marsh INTENT AND PURPOSE. The paper aims to further integrated design of low energy buildings with high architectural quality. A precondition for qualified integrated design is a holistic approach...... that on the technical side covers all sorts of energy used to construct, run and use modern buildings, and on the humane side includes functional, social and aesthetic aspects of modern living. The paper shows how qualified integrated design up till now has not been achieved. It shows how a narrow focus on the solution...... of sub-problems may result in big problems elsewhere in the complex system of designing buildings. The paper concludes that future ambitious low energy building strategies cannot focus only on heat consumption but must include a stronger focus on the use of electricity for non-heating purposes...

  8. Generic robot architecture

    Science.gov (United States)

    Bruemmer, David J [Idaho Falls, ID; Few, Douglas A [Idaho Falls, ID

    2010-09-21

    The present invention provides methods, computer readable media, and apparatuses for a generic robot architecture providing a framework that is easily portable to a variety of robot platforms and is configured to provide hardware abstractions, abstractions for generic robot attributes, environment abstractions, and robot behaviors. The generic robot architecture includes a hardware abstraction level and a robot abstraction level. The hardware abstraction level is configured for developing hardware abstractions that define, monitor, and control hardware modules available on a robot platform. The robot abstraction level is configured for defining robot attributes and provides a software framework for building robot behaviors from the robot attributes. Each of the robot attributes includes hardware information from at least one hardware abstraction. In addition, each robot attribute is configured to substantially isolate the robot behaviors from the at least one hardware abstraction.

  9. Exploring Urban Screens

    Directory of Open Access Journals (Sweden)

    Zlatan Krajina

    2009-12-01

    Full Text Available There is a tautological tendency in the widespread claims that urban space is 'me-diated'. Never before has the citizen, it is argued, been confronted with such an unprecedented array of signage. I depart from the rhetoric of 'biggest-ever-saturation' as not necessarily untrue, but as insufficient in exploring the diverse spatial operations of urban screens. I examine some contemporary cases of ani-mated architectural surfaces, informational panels, and advertising billboards, with reference to much longer standing cultural practices of spatial management in modern cities, such as illumination, to suggest that the contemporary display media do not mediate the city anew but re-invent urban space as a field of ubiqui-tous mediation. From that standpoint I suggest exploring urban screens as a both singular visual agents and indivisible items in plural structural assemblages, b complementary forces of public illumination, and c complex perceptual platforms in visual play of scale and distance.

  10. Sustainable Enterprise Architecture

    CERN Document Server

    Hausman, Kirk

    2011-01-01

    Providing guidance that can be applied to an enterprise of any scale, this book supplies IT practitioners with the tools needed to present enterprise architecture concepts to non-technical stakeholders. Rather than focusing on a single governance framework, the text explains how to develop successful and sustainable enterprise deployments in any setting. Coverage includes general security practices, common threats, storage mechanisms, and the impact of virtualization. The author presents functional considerations for developing and maintaining extended enterprise networks using practices teste

  11. Architecture of Trusted PC

    Institute of Scientific and Technical Information of China (English)

    WU Shuhua; ZHU Yuefei

    2006-01-01

    This paper, focusing on the trusted computing group's standards, explained the key concept of trusted computing and provided the architecture of trusted PC. It built trust bottom-up by starting with trusted hardware and adding layers of trusted software. It is a system-level solution available to all applications running on the member platforms. This solution reduces the security burden on applications and thus simplifies application programming.

  12. Avionics Architecture Modelling Language

    Science.gov (United States)

    Alana, Elena; Naranjo, Hector; Valencia, Raul; Medina, Alberto; Honvault, Christophe; Rugina, Ana; Panunzia, Marco; Dellandrea, Brice; Garcia, Gerald

    2014-08-01

    This paper presents the ESA AAML (Avionics Architecture Modelling Language) study, which aimed at advancing the avionics engineering practices towards a model-based approach by (i) identifying and prioritising the avionics-relevant analyses, (ii) specifying the modelling language features necessary to support the identified analyses, and (iii) recommending/prototyping software tooling to demonstrate the automation of the selected analyses based on a modelling language and compliant with the defined specification.

  13. Urban architecture in urban renewal

    DEFF Research Database (Denmark)

    Holmgren, Steen; Svensson, Ole

    2001-01-01

    and without obvious architectural value. These issues raise pertinent questions: what urban architectural problems and qualities exist in the complex, inner suburbs? What differences exist between professionals' and residents' perceptions and assessments of urban architecture? How can a shared language...... of urban architecture be developed? This research project attempts to answer these questions through a discourse on theories and methods and the development of "dialogue methods" by which professionals can learn about residents' perception of the urban architecture of their area, thus achieving a better...

  14. Paneling architectural freeform surfaces

    KAUST Repository

    Eigensatz, Michael

    2010-07-25

    The emergence of large-scale freeform shapes in architecture poses big challenges to the fabrication of such structures. A key problem is the approximation of the design surface by a union of patches, so-called panels, that can be manufactured with a selected technology at reasonable cost, while meeting the design intent and achieving the desired aesthetic quality of panel layout and surface smoothness. The production of curved panels is mostly based on molds. Since the cost of mold fabrication often dominates the panel cost, there is strong incentive to use the same mold for multiple panels. We cast the major practical requirements for architectural surface paneling, including mold reuse, into a global optimization framework that interleaves discrete and continuous optimization steps to minimize production cost while meeting user-specified quality constraints. The search space for optimization is mainly generated through controlled deviation from the design surface and tolerances on positional and normal continuity between neighboring panels. A novel 6-dimensional metric space allows us to quickly compute approximate inter-panel distances, which dramatically improves the performance of the optimization and enables the handling of complex arrangements with thousands of panels. The practical relevance of our system is demonstrated by paneling solutions for real, cutting-edge architectural freeform design projects.

  15. Quantifying loopy network architectures.

    Directory of Open Access Journals (Sweden)

    Eleni Katifori

    Full Text Available Biology presents many examples of planar distribution and structural networks having dense sets of closed loops. An archetype of this form of network organization is the vasculature of dicotyledonous leaves, which showcases a hierarchically-nested architecture containing closed loops at many different levels. Although a number of approaches have been proposed to measure aspects of the structure of such networks, a robust metric to quantify their hierarchical organization is still lacking. We present an algorithmic framework, the hierarchical loop decomposition, that allows mapping loopy networks to binary trees, preserving in the connectivity of the trees the architecture of the original graph. We apply this framework to investigate computer generated graphs, such as artificial models and optimal distribution networks, as well as natural graphs extracted from digitized images of dicotyledonous leaves and vasculature of rat cerebral neocortex. We calculate various metrics based on the asymmetry, the cumulative size distribution and the Strahler bifurcation ratios of the corresponding trees and discuss the relationship of these quantities to the architectural organization of the original graphs. This algorithmic framework decouples the geometric information (exact location of edges and nodes from the metric topology (connectivity and edge weight and it ultimately allows us to perform a quantitative statistical comparison between predictions of theoretical models and naturally occurring loopy graphs.

  16. The TDAQ Baseline Architecture

    CERN Multimedia

    Wickens, F J

    The Trigger-DAQ community is currently busy preparing material for the DAQ, HLT and DCS TDR. Over the last few weeks a very important step has been a series of meetings to complete agreement on the baseline architecture. An overview of the architecture indicating some of the main parameters is shown in figure 1. As reported at the ATLAS Plenary during the February ATLAS week, the main area where the baseline had not yet been agreed was around the Read-Out System (ROS) and details in the DataFlow. The agreed architecture has: Read-Out Links (ROLs) from the RODs using S-Link; Read-Out Buffers (ROB) sited near the RODs, mounted in a chassis - today assumed to be a PC, using PCI bus at least for configuration, control and monitoring. The baseline assumes data aggregation, in the ROB and/or at the output (which could either be over a bus or in the network). Optimization of the data aggregation will be made in the coming months, but the current model has each ROB card receiving input from 4 ROLs, and 3 such c...

  17. Paneling architectural freeform surfaces

    KAUST Repository

    Eigensatz, Michael

    2010-07-26

    The emergence of large-scale freeform shapes in architecture poses big challenges to the fabrication of such structures. A key problem is the approximation of the design surface by a union of patches, socalled panels, that can be manufactured with a selected technology at reasonable cost, while meeting the design intent and achieving the desired aesthetic quality of panel layout and surface smoothness. The production of curved panels is mostly based on molds. Since the cost of mold fabrication often dominates the panel cost, there is strong incentive to use the same mold for multiple panels. We cast the major practical requirements for architectural surface paneling, including mold reuse, into a global optimization framework that interleaves discrete and continuous optimization steps to minimize production cost while meeting user-specified quality constraints. The search space for optimization is mainly generated through controlled deviation from the design surface and tolerances on positional and normal continuity between neighboring panels. A novel 6-dimensional metric space allows us to quickly compute approximate inter-panel distances, which dramatically improves the performance of the optimization and enables the handling of complex arrangements with thousands of panels. The practical relevance of our system is demonstrated by paneling solutions for real, cutting-edge architectural freeform design projects. © 2010 ACM.

  18. Conflict, Space and Architecture

    Directory of Open Access Journals (Sweden)

    Marc Schoonderbeek

    2017-02-01

    Full Text Available Footprint 19 focuses on the more recent roles of architecture in the contemporary spaces of conflict. Departing from a spatial understanding of geopolitical, climatological and economical conflicts, the various contributions highlight the large scale and phenomenal transitions in the physical world and in society by extrapolating, through examples, the abundance of relations that can be traced between conflict, territory and architecture. Conflict areas often prove to be fertile grounds for innovation and for the emergence of new spatial forms. The issue reports on the state of perpetual global unrest in architecture through a series of articles and case studies that highlight the consequences of conflicts in the places and spaces that we inhabit. In the introduction, these are discussed as an interlinked global reality rather than as isolated incidents. In doing so, the contemporary spaces of conflict are positioned in the context of emerging global trends, conditions, and discourses in the attempt to address their indicative symptoms while reflecting on their underlying causes.

  19. The influence of modern Chinese architectural landscape landscape painting aesthetics

    Institute of Scientific and Technical Information of China (English)

    杨永伟

    2016-01-01

    the modern architecture to the spread of Chinese localization were style of architecture, this article is based on the research on localization urban landscape to explore traditional Chinese landscape painting aesthetics and the cognitive way of Chinese garden aesthetics art, through the Chinese traditional aesthetics to explore the modern people and the nature harmonious living environment, the traditional aesthetic concept of “landscape” for the development of Chinese modern city landscape, qian xuesen proposed the concept of “landscape city” and the development, purpose is to find the environment concept of Chinese national culture characteristics.

  20. Teratoid Wilms′ tumor - A rare renal tumor

    Directory of Open Access Journals (Sweden)

    Biswanath Mukhopadhyay

    2011-01-01

    Full Text Available Teratoid Wilms′ tumor is an extremely rare renal tumor. We report a case of unilateral teratoid Wilms′ tumor in a 4-year-old girl. The patient was admitted with a right-sided abdominal mass. The mass was arising from the right kidney. Radical nephrectomy was done and the patient had an uneventful recovery. Histopathology report showed teratoid Wilms′ tumor.

  1. Optimization of Highly Architectured Stereolithographic Microtrusses

    Science.gov (United States)

    Bird, Adam Gregory

    Stereolithography allows architectural freedom which can be used to fabricate optimal architectures with the potential for significant enhancements in structural efficiency. In this study, buckling behaviour of compressive struts is explored. Experimental failure stress values for stereolithographic polymer tubes are found to agree with existing predictive models for Euler and local shell buckling, validating the methodology. Experimental testing on a space frame compressive strut design proposed in literature reveals end constraints between fixed and free, and stereolithographic design freedom is considered to reduce over-engineered features, improving performance. Finally, a novel sandwich wall tubular strut design is introduced: experimental results show successful inhibition of local shell buckling while also enhancing Euler buckling performance (improvements of 45% and 30% in failure strength when compared to equal-mass simple tubes, respectively). A new failure mode termed "wall splitting" is identified, and a preliminary model is developed to predict the increases in failure stress.

  2. The Impact of Basic Architectural Design

    DEFF Research Database (Denmark)

    Naboni, Emanuele; Malcangi, Antonio

    2015-01-01

    The research explores the impact of the shape, construction type, materials and components of buildings and users' scenarios – on buildings' key energy loads (heating, cooling and lighting) in Copenhagen's climate. Applying a genetic algorithm, a search space consisting of over 408,000 simulated...... by proper basic design choices based on energy simulation coupled with genetic optimization. The Impact of Basic Architectural Design. Thinking beyond BR10 and Passivhaus Standard Prescriptions with the Use of Genetic Optimization (PDF Download Available). Available from: https......://www.researchgate.net/publication/287994281_The_Impact_of_Basic_Architectural_Design_Thinking_beyond_BR10_and_Passivhaus_Standard_Prescriptions_with_the_Use_of_Genetic_Optimization [accessed Jan 21, 2016]....

  3. Sculpture Versus Architecture?

    Directory of Open Access Journals (Sweden)

    Alexander Rappaport

    2007-07-01

    Full Text Available Many critics consider Richard Serra the leading sculptor of the 20th century. He is famous not only for inventing something new in sculpture (abstract sculpture compositions existed before him, having been opened by constructivist vanguard of the beginning of the 20th century. Material selections by Vladimir Tatlin and sculptures by Osip Tsadkin, as well as compositions by Henry Moor appeared before Serra. Serra is famous for transferring his works' accent from the works as they are, which could be installed in any place, to their environment. That is he saw in the sculpture a key to understanding the urban space. His crude metal sheets and profiles, rectangular and curvilinear, exceeding regular scale of sculpture, come closer to architecture. Richard Serra places them near architectural constructions as checkpoints of intermediate scale category of space located between so-called «street furniture» – lamp posts, stalls, fountains and benches – and buildings, especially huge modern ones.But the matter is not only in the scale. Serra's sculptures are not only abstract compositions that harmoniously add to the space with their spacious scale. They have some mystery, some implicit sense appearing before a pedestrian as an enigma. Their mystique opposes both street furniture and architecture. But first of all it opposes the historical sculpture with its enigma always overshadowed by historical or biographical topic. Krylov's sculpture in the Summer Garden or Minin and Pozharsky's monument on the Red Square do not strike us, because we know that those monuments are erected IN COMMEMORATION of prominent people, as fellow citizens' tribute to their great contribution to the national history. But the crude metal sheets welded at different angles – what are they for? Who needs them?As an art critic, Edward Goldman, said, fame came to Richard Serra in 1989, when the sculpture composition Tilted Arc erected eight years before it was demolished by

  4. Human Organotypic Lung Tumor Models: Suitable For Preclinical 18F-FDG PET-Imaging

    OpenAIRE

    Fecher, David; Hofmann, Elisabeth; Buck, Andreas; BUNDSCHUH, RALPH; Nietzer, Sarah; Dandekar, Gudrun; Walles, Thorsten; Walles, Heike; Lückerath, Katharina; Steinke, Maria

    2016-01-01

    Development of predictable in vitro tumor models is a challenging task due to the enormous complexity of tumors in vivo. The closer the resemblance of these models to human tumor characteristics, the more suitable they are for drug-development and –testing. In the present study, we generated a complex 3D lung tumor test system based on acellular rat lungs. A decellularization protocol was established preserving the architecture, important ECM components and the basement membrane of the lung. ...

  5. 调理亚健康与肿瘤防治策略的初步探讨%The Preliminary Exploration into Regulating Sub-health as Preventive and Therapeutic Strategies for Tumor

    Institute of Scientific and Technical Information of China (English)

    林举择; 王昌俊

    2012-01-01

    The definition of sub-health was studied from the angle of tumor dormancy again. We believe it is necessary to further supplement the present definition, diagnosis criteria, and assessment means. The definition of sub-disease and the division of a disease into four development stages (health→sub-health→sub-disease→ disease) were also brought up. Furthermore, we believe that application of regulating sub-health as preventive and therapeutic strategies for tumor is an anti-cancer method with Chinese features, which enriches the modern theories of tumor prevention and therapy.%本文拟从肿瘤休眠角度重新探讨亚健康的定义,认为目前亚健康的定义、诊断标准和评价手段还需进一步完善,并提出亚疾病的概念和健康→亚健康→亚疾病→疾病4个发展阶段的见解,进而从目前肿瘤防治的现状和难点出发,认为中医调理亚健康应用于肿瘤防治,是具有中国特色的中西医结合防癌手段,这一见解和手段丰富了现代肿瘤防治学的理论.

  6. Exploration Medical System Technical Development

    Science.gov (United States)

    McGuire, K.; Middour, C.; Cerro, J.; Burba, T.; Hanson, A.; Reilly, J.; Mindock, J.

    2017-01-01

    The Exploration Medical Capability (ExMC) Element systems engineering goals include defining the technical system needed to implement exploration medical capabilities for Mars. This past year, scenarios captured in the medical system concept of operations laid the foundation for systems engineering technical development work. The systems engineering team analyzed scenario content to identify interactions between the medical system, crewmembers, the exploration vehicle, and the ground system. This enabled the definition of functions the medical system must provide and interfaces to crewmembers and other systems. These analyses additionally lead to the development of a conceptual medical system architecture. The work supports the ExMC community-wide understanding of the functional exploration needs to be met by the medical system, the subsequent development of medical system requirements, and the system verification and validation approach utilizing terrestrial analogs and precursor exploration missions.

  7. Architectural communication: Intra and extra activity of architecture

    Directory of Open Access Journals (Sweden)

    Stamatović-Vučković Slavica

    2013-01-01

    Full Text Available Apart from a brief overview of architectural communication viewed from the standpoint of theory of information and semiotics, this paper contains two forms of dualistically viewed architectural communication. The duality denotation/connotation (”primary” and ”secondary” architectural communication is one of semiotic postulates taken from Umberto Eco who viewed architectural communication as a semiotic phenomenon. In addition, architectural communication can be viewed as an intra and an extra activity of architecture where the overall activity of the edifice performed through its spatial manifestation may be understood as an act of communication. In that respect, the activity may be perceived as the ”behavior of architecture”, which corresponds to Lefebvre’s production of space.

  8. Exploring Enterprise, System of Systems, and System and Software Architectures

    Science.gov (United States)

    2016-06-13

    might. • For example, software architects often lament the lateness with which they are brought into system engineering projects. • All of these...Enterprise architects compose holistic solutions that address the business challenges of the enterprise and support the governance needed to...network. • Today, Army systems are connected to inter-agency networks, and change management is even more critical. • Army enterprise architects must

  9. Exploring Architectural Details Through a Wearable Egocentric Vision Device

    Directory of Open Access Journals (Sweden)

    Stefano Alletto

    2016-02-01

    Full Text Available Augmented user experiences in the cultural heritage domain are in increasing demand by the new digital native tourists of 21st century. In this paper, we propose a novel solution that aims at assisting the visitor during an outdoor tour of a cultural site using the unique first person perspective of wearable cameras. In particular, the approach exploits computer vision techniques to retrieve the details by proposing a robust descriptor based on the covariance of local features. Using a lightweight wearable board, the solution can localize the user with respect to the 3D point cloud of the historical landmark and provide him with information about the details at which he is currently looking. Experimental results validate the method both in terms of accuracy and computational effort. Furthermore, user evaluation based on real-world experiments shows that the proposal is deemed effective in enriching a cultural experience.

  10. Exploring Alternative Topologies for Network-on-Chip Architectures

    Directory of Open Access Journals (Sweden)

    Shafi Patel

    2011-01-01

    Full Text Available With increase in integration density and complexity of the system-on-Chip (SOC, the conventional interconnects are not suitable to fulfill the demands. The application of traditional network technologies in the form of Network-on-Chip is a potential solution. NoC design space has many variables. Selection of a better topology results in lesser complexities and better power-efficiency. In the proposed work, key research area in Network-on-chip design targeting communication infrastructure specially focusing on optimized topology design is worked upon. The simulation is modeled using a conventional network simulator tool packet tracer 5.3, in which by selecting proposed Topology 35.7 % reduction in traversing the longest path is observed.

  11. Shared Memory Architecture and Explored Alternatives for Interoperability

    Science.gov (United States)

    2007-12-01

    S Services orchestration choreography Service Provider / BrokerRequestor Discovery publish seek interact Svc (programming in-the-large) (programming...Threat CAS Urban CAS Time Sensitive Strike Orchestration of Analytical Activities Choreography of Agent Interactions Orchestration of Analytical...Activities Choreography of Agent Interactions ACETEF Stimulators JIMM I/F I/F MFS EOIR ACETEF Interface Library Linked Base Class Threat Generator

  12. Architecture exploration of FPGA based accelerators for bioinformatics applications

    CERN Document Server

    Varma, B Sharat Chandra; Balakrishnan, M

    2016-01-01

    This book presents an evaluation methodology to design future FPGA fabrics incorporating hard embedded blocks (HEBs) to accelerate applications. This methodology will be useful for selection of blocks to be embedded into the fabric and for evaluating the performance gain that can be achieved by such an embedding. The authors illustrate the use of their methodology by studying the impact of HEBs on two important bioinformatics applications: protein docking and genome assembly. The book also explains how the respective HEBs are designed and how hardware implementation of the application is done using these HEBs. It shows that significant speedups can be achieved over pure software implementations by using such FPGA-based accelerators. The methodology presented in this book may also be used for designing HEBs for accelerating software implementations in other domains besides bioinformatics. This book will prove useful to students, researchers, and practicing engineers alike.

  13. EXPLORATION GEOCHEMISTRY

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    <正>20072782 Dong Sheng(East China Academy of Metallurgical Geological Exploration,Hefei 230022,China)Regional Geochemical Characteristics of Guichi Area in Anhui Province and Their Ore-Prospecting Significance(Geophysical and Geochemical Exploration,ISSN1000-8918,CN11-1906/P,30(3),2006,p.215-219,223,3 illus.,7 refs.)Key words:polymetallic deposits,regional geological exploration,Anhui Province Controlled by unique geological conditions,

  14. PROSPECTING EXPLORATION

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>20082879 Chen Yaoyu(No.3 Geology and Mineral Exploration Team,Gansu Provincial Bureau of Geology and Mineral Exploration and Development,Lanzhou 730050,China); Gong Quansheng Discussion on the Division of Deposit Scale and the Index of Ore Prospecting(Gansu Geology,ISSN 1004—4116,CN62—1191/P,16(3),2007,p.6—11,4 tables,6 refs.) Key words:prospecting and exploration of mineral

  15. GEOCHEMICAL EXPLORATION

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    <正>20122626 Li Dongfeng ( Liaoning Institute of Mineral Resources Exploration,Shenyang 110032,China ) Application of Comprehensive Geophysical-Geochemical Method in Toudao-yingzi Gold Field ( Journal of Liaoning Technical University ( Natural Sciences ), ISSN1008-0562,CN21-1379 / N,30 ( 6 ), 2011,p.849-852,1illus.,2tables,10refs. ) Key words:gold ores,geophysical exploration,geochemical exploration,Liaoning Province

  16. Creative Exploration

    OpenAIRE

    2016-01-01

    Children are naturally curious and explore in order to make sense of the world; play and exploration are vital to their learning and development. Space and support for children to think, ask questions, make predictions, experiment, look for explanations and draw conclusions is essential in primary science. This ‘children’s science’ emerges naturally as they seek to learn about the world around them (Johnston 2008) and develop creative explanations of natural phenomena. Adopting such an explor...

  17. Resilience Theory and Praxis: a Critical Framework for Architecture

    Directory of Open Access Journals (Sweden)

    Michelle Laboy

    2016-12-01

    Full Text Available The growing use of resilience as a goal of architectural practice presents a new challenge in architects’ responsibility to health, safety, welfare and poetic expression of human-building interaction. With roots in disaster response, resilience in the building industry emphasizes the preservation and rapid restoration of the physical environment’s normal function in the face of shocks and disturbances of limited duration. The focus on maintaining function, and/or rapidly returning to the status quo ante necessarily affords a narrow understanding of architecture and a limited view of the concept of resilience. While useful at certain scales of time and inquiry, this so-called engineering resilience approach is only one among many within the broad discourse across diverse disciplines such as psychology, economics, and ecology.  Drawing on the academic and professional literature of resilience outside the discipline, this paper explores the multiple competing frameworks represented, considers their influences and implications for architecture and the built environment at multiple scales, and examines the overlaps with existing discourse on change, architecture and time. The analysis of alternative concepts enables a critical perspective to move beyond the circumscribed, functionalist approach afforded by engineering resilience currently guiding architecture practice, towards a framework of social- ecological resilience that can fully embrace the richness of architecture, and results in a necessary and clear theoretical basis for the resilience of architecture over time in a climate of increasing uncertainty.

  18. Cholecystokinin expression in tumors

    DEFF Research Database (Denmark)

    Rehfeld, Jens F

    2016-01-01

    in different neuroendocrine tumors; cerebral gliomas and astrocytomas and specific pediatric tumors. Tumor hypersecretion of CCK was recently reported in a patient with a metastatic islet cell tumor and hypercholecystokininemia resulting in a novel tumor syndrome, the cholecystokininoma syndrome. This review...... presents an overview of the cell-specific biogenesis of CCK peptides, and a description of the CCK expression in tumors and of the cholecystokininoma syndrome. Finally, assays for the diagnosis of CCK-producing tumors are reviewed....

  19. On the Architectural Engineering Competences in Architectural Design

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning

    2007-01-01

    In 1997 a new education in Architecture & Design at Department of Architecture and Design, Aalborg University was started with 50 students. During the recent years this number has increased to approximately 100 new students each year, i.e. approximately 500 students are following the 3 years bach...... competences related to the specialization in Architectural Design. A detailed presentation can be found at the homepage: www.aod.aau.dk....

  20. ARQUITECTURAS INVISIBLES / Invisible Architecture

    Directory of Open Access Journals (Sweden)

    Francisco Javier Montero Fernández

    2012-11-01

    questions that go beyond quality. Political or commercial interests tend to confuse the opportunity for promotion with the merit of the project. It would be possible to number many competitions which have supposed a significant advance in architecture in the last century; a certain nostalgia for those times of debate which, together with other similar formulas such as entries in biennials, triennials or exhibitions, were capable of making empirical research from direct practice. On the contrary, today the policy framework of the architectural project is often defined in a manner foreign to real architecture, administratively dominated by a process that prioritizes legal and technical compliance over the quality of the project itself, confusing the means with the end. Criticism always aims at the author; it forgets the notable procedures which armed a jury gratuitously exonerated of responsibility or that legal framework that asphyxiates both architecture and the spirit of inquiry which should always prevail.This issue of the journal considers the assimilation of the competition into a research process parallel to an architecture united with quality and progress, an advanced architecture.

  1. The EPOS ICT Architecture

    Science.gov (United States)

    Jeffery, Keith; Harrison, Matt; Bailo, Daniele

    2016-04-01

    The EPOS-PP Project 2010-2014 proposed an architecture and demonstrated feasibility with a prototype. Requirements based on use cases were collected and an inventory of assets (e.g. datasets, software, users, computing resources, equipment/detectors, laboratory services) (RIDE) was developed. The architecture evolved through three stages of refinement with much consultation both with the EPOS community representing EPOS users and participants in geoscience and with the overall ICT community especially those working on research such as the RDA (Research Data Alliance) community. The architecture consists of a central ICS (Integrated Core Services) consisting of a portal and catalog, the latter providing to end-users a 'map' of all EPOS resources (datasets, software, users, computing, equipment/detectors etc.). ICS is extended to ICS-d (distributed ICS) for certain services (such as visualisation software services or Cloud computing resources) and CES (Computational Earth Science) for specific simulation or analytical processing. ICS also communicates with TCS (Thematic Core Services) which represent European-wide portals to national and local assets, resources and services in the various specific domains (e.g. seismology, volcanology, geodesy) of EPOS. The EPOS-IP project 2015-2019 started October 2015. Two work-packages cover the ICT aspects; WP6 involves interaction with the TCS while WP7 concentrates on ICS including interoperation with ICS-d and CES offerings: in short the ICT architecture. Based on the experience and results of EPOS-PP the ICT team held a pre-meeting in July 2015 and set out a project plan. The first major activity involved requirements (re-)collection with use cases and also updating the inventory of assets held by the various TCS in EPOS. The RIDE database of assets is currently being converted to CERIF (Common European Research Information Format - an EU Recommendation to Member States) to provide the basis for the EPOS-IP ICS Catalog. In

  2. The Salman Mosque: Achmad Noe’man’s Critique of Indonesian Conventional Mosque Architecture

    Science.gov (United States)

    Holik, A. A. R.; Aryanti, T.

    2017-03-01

    The Salman Mosque, designed by Achmad Noe’man, was a striking Islamic architectural design in the 1960s when it was built. Unlike the conventional mosques, particularly in Indonesia, it has no dome. Instead, the roof was made of prestressed concrete and resembles a canoe. Using data drawn from field observations, this paper explores the architectural characteristics of the Salman Mosque as a product of Modern architecture. It argues that the domeless mosque, the simple minaret, the wooden wall panels and floor, the women’s balcony, and the roof demonstrate architectural modernism, as opposed to the conventional mosque typology that flourished in Indonesia at the time. This paper further argues that the Salman Mosque is Noe’man’s critique of the Indonesian conventional mosque architecture. It concludes that the architectural features of the Salman Mosque reflects Noe’man’s modern vision of Islam and Islamic architecture.

  3. Coherent Architecture Development as a Basis for Technology Development

    DEFF Research Database (Denmark)

    Ravn, Poul Martin

    coherence. Despite the acceptance and results presented in multiple studies from the application of architectures, the research on architecture work in a technology development context is limited. Technologies are often developed and represented in the form of product sub-systems that are made available......The subject of this PhD thesis is architecture-centered design. It elaborates especially on two specific areas: the coherence in architectures in a technology development context and the identification of critical development areas via property-based reasoning, based on an understanding of cette...... for product developers. Technologies, which in their infancy indicate a 'jack of all trades, master of none', have a risk of being developed without a clearly defined need or identification of which products it can be used in. A common approach for developing such a technology includes exploration of what...

  4. Art of Film – A Way of Architectural Communication

    Directory of Open Access Journals (Sweden)

    Liliana Petrovici

    2009-01-01

    Full Text Available The art of film, the most popular art of the 20th century, can represent for architecture a means of teaching and promoting its specific values, an inspirational source and a good example of efficient and accessible cultural communication. The architecture presents many resemblances with the world of film regarding the concept and space exploring for communicating some ideas or concepts. Both film and architecture have narrative qualities, work with the world of illusions and representations and compose various elements in order to carry on certain significances. The film makers are making available the suggestive and semantic potential of architecture to render states and attitudes, to outline certain meanings or to emit opinions and comments on political, psychological and social issues.

  5. Disruptive Logic Architectures and Technologies From Device to System Level

    CERN Document Server

    Gaillardon, Pierre-Emmanuel; Clermidy, Fabien

    2012-01-01

    This book discusses the opportunities offered by disruptive technologies to overcome the economical and physical limits currently faced by the electronics industry. It provides a new methodology for the fast evaluation of an emerging technology from an architectural perspective and discusses the implications from simple circuits to complex architectures. Several technologies are discussed, ranging from 3-D integration of devices (Phase Change Memories, Monolithic 3-D, Vertical NanoWires-based transistors) to dense 2-D arrangements (Double-Gate Carbon Nanotubes, Sublithographic Nanowires, Lithographic Crossbar arrangements). Novel architectural organizations, as well as the associated tools, are presented in order to explore this freshly opened design space. Describes a novel architectural organization for future reconfigurable systems; Includes a complete benchmarking toolflow for emerging technologies; Generalizes the description of reconfigurable circuits in terms of hierarchical levels; Assesses disruptive...

  6. Geometrical objects architecture and the mathematical sciences 1400-1800

    CERN Document Server

    2014-01-01

    This volume explores the mathematical character of architectural practice in diverse pre- and early modern contexts. It takes an explicitly interdisciplinary approach, which unites scholarship in early modern architecture with recent work in the history of science, in particular, on the role of practice in the scientific revolution. As a contribution to architectural history, the volume contextualizes design and construction in terms of contemporary mathematical knowledge, attendant forms of mathematical practice, and relevant social distinctions between the mathematical professions. As a contribution to the history of science, the volume presents a series of micro-historical studies that highlight issues of process, materiality, and knowledge production in specific, situated, practical contexts. Our approach sees the designer’s studio, the stone-yard, the drawing floor, and construction site not merely as places where the architectural object takes shape, but where mathematical knowledge itself is depl...

  7. AUGMENTED REALITY BROWSERS: A PROPOSAL FOR ARCHITECTURAL STANDARDIZATION

    Directory of Open Access Journals (Sweden)

    Fernando Sambinelli

    2015-01-01

    Full Text Available The technology evolution of smartphones, systems and the growing of telecommunications, allow the use of Augmented Reality in the exploration of geo-referenced information, complementing the real environment of the users with various types of content displayed on robust mobile cameras through applications called augmented reality browsers. Although this type of application is being in development and growing use by society, the technology, and especially its software architecture do not have any kind of standardization. This work presents concepts about augmented reality browsers for mobile devices. It shows the main aspects and applications of those types of reality. Besides that, the specific features of those types of architecture are discussed and compared, and new architecture, whose most relevant feature is the interoperability of applications in various platforms for mobile devices, are presented. This work has the objective to develop an architectural framework for the development of these browsers.

  8. An event-based architecture for solving constraint satisfaction problems

    Science.gov (United States)

    Mostafa, Hesham; Müller, Lorenz K.; Indiveri, Giacomo

    2015-12-01

    Constraint satisfaction problems are ubiquitous in many domains. They are typically solved using conventional digital computing architectures that do not reflect the distributed nature of many of these problems, and are thus ill-suited for solving them. Here we present a parallel analogue/digital hardware architecture specifically designed to solve such problems. We cast constraint satisfaction problems as networks of stereotyped nodes that communicate using digital pulses, or events. Each node contains an oscillator implemented using analogue circuits. The non-repeating phase relations among the oscillators drive the exploration of the solution space. We show that this hardware architecture can yield state-of-the-art performance on random SAT problems under reasonable assumptions on the implementation. We present measurements from a prototype electronic chip to demonstrate that a physical implementation of the proposed architecture is robust to practical non-idealities and to validate the theory proposed.

  9. Enterprise architecture evaluation using architecture framework and UML stereotypes

    Directory of Open Access Journals (Sweden)

    Narges Shahi

    2014-08-01

    Full Text Available There is an increasing need for enterprise architecture in numerous organizations with complicated systems with various processes. Support for information technology, organizational units whose elements maintain complex relationships increases. Enterprise architecture is so effective that its non-use in organizations is regarded as their institutional inability in efficient information technology management. The enterprise architecture process generally consists of three phases including strategic programing of information technology, enterprise architecture programing and enterprise architecture implementation. Each phase must be implemented sequentially and one single flaw in each phase may result in a flaw in the whole architecture and, consequently, in extra costs and time. If a model is mapped for the issue and then it is evaluated before enterprise architecture implementation in the second phase, the possible flaws in implementation process are prevented. In this study, the processes of enterprise architecture are illustrated through UML diagrams, and the architecture is evaluated in programming phase through transforming the UML diagrams to Petri nets. The results indicate that the high costs of the implementation phase will be reduced.

  10. ARCHITECTURAL CONCEPTS IN THE RUSSIAN IDEAS IN THE BEGINNING OF THE 19TH CENTURY

    Directory of Open Access Journals (Sweden)

    Labanov Sergey Sergeevich

    2014-12-01

    Full Text Available The given paper for the first time explores the ideas of architecture expressed by Russian thinkers of the first half of the 19th century: K.N. Batyushkov, N.M. Karamzin, Lyubomudry, A.S. Pushkin, A.S. Griboyedov, A.S. Khomyakov, I.V. Kireyevsky, representatives of the theory of official nationality, N.V. Kukolnik, P.Ya. Chaadayev, their evaluation of architectural styles of the ancient, Byzantine architecture, Gothic style, Romantic period.

  11. Convolutional neural network architectures for predicting DNA–protein binding

    Science.gov (United States)

    Zeng, Haoyang; Edwards, Matthew D.; Liu, Ge; Gifford, David K.

    2016-01-01

    Motivation: Convolutional neural networks (CNN) have outperformed conventional methods in modeling the sequence specificity of DNA–protein binding. Yet inappropriate CNN architectures can yield poorer performance than simpler models. Thus an in-depth understanding of how to match CNN architecture to a given task is needed to fully harness the power of CNNs for computational biology applications. Results: We present a systematic exploration of CNN architectures for predicting DNA sequence binding using a large compendium of transcription factor datasets. We identify the best-performing architectures by varying CNN width, depth and pooling designs. We find that adding convolutional kernels to a network is important for motif-based tasks. We show the benefits of CNNs in learning rich higher-order sequence features, such as secondary motifs and local sequence context, by comparing network performance on multiple modeling tasks ranging in difficulty. We also demonstrate how careful construction of sequence benchmark datasets, using approaches that control potentially confounding effects like positional or motif strength bias, is critical in making fair comparisons between competing methods. We explore how to establish the sufficiency of training data for these learning tasks, and we have created a flexible cloud-based framework that permits the rapid exploration of alternative neural network architectures for problems in computational biology. Availability and Implementation: All the models analyzed are available at http://cnn.csail.mit.edu. Contact: gifford@mit.edu Supplementary information: Supplementary data are available at Bioinformatics online. PMID:27307608

  12. Chipless RFID reader architecture

    CERN Document Server

    Karmakar, Nemai Chandra; Kalansuriya, Prasanna

    2013-01-01

    In the era of information communication technology (ICT), radio frequency identification (RFID) has been going through tremendous development. RFID technology has the potential of replacing barcodes due to its large information carrying capacity, flexibility in operations, and applications. The deployment of RFID has been hindered by its cost. However, with the advent of low powered ICs, energy scavenging techniques, and low-cost chipless tags, RFID technology has achieved significant development. This book addresses the new reader architecture, presents fundamentals of chipless RFID systems,

  13. Die-stacking architecture

    CERN Document Server

    Xie, Yuan

    2015-01-01

    The emerging three-dimensional (3D) chip architectures, with their intrinsic capability of reducing the wire length, promise attractive solutions to reduce the delay of interconnects in future microprocessors. 3D memory stacking enables much higher memory bandwidth for future chip-multiprocessor design, mitigating the ""memory wall"" problem. In addition, heterogenous integration enabled by 3D technology can also result in innovative designs for future microprocessors. This book first provides a brief introduction to this emerging technology, and then presents a variety of approaches to design

  14. Game engine architecture

    CERN Document Server

    Gregory, Jason

    2014-01-01

    ""… this book is the best of its kind, and you're lucky to have found it. It covers the huge field of game engine architecture in a succinct, clear way, and expertly balances the breadth and depth of its coverage, offering enough detail that even a beginner can easily understand the concepts it presents. The author, Jason Gregory, is not only a world expert in his field; he's a working programmer with production-quality knowledge and many shipped game projects under his belt. … Jason is also an experienced educator who has taught in the top-ranked university game program in North America. …

  15. Architecture Building Sustainability

    Institute of Scientific and Technical Information of China (English)

    DAVID HENDRICKSON

    2006-01-01

    @@ Leading architectural design and engineering firm, Skidmore,Owings, & Merrill (SOM), is renowned for pushing the envelope, masterminding some of the world's most cutting edge and enduring structural masterpieces - America's tallest building, the Sears Tower,in the firm's home city of Chicago, the 88-story Jinmao Tower in Shanghai, and the Freedom Tower in New York City, successor to the fallen World Trade Center complex,are among the well known projects in its building portfolio. SOM's next high profile assignment, the Pearl River Tower, in Guangzhou is one no less worthy of this tradition.

  16. Mobile networks architecture

    CERN Document Server

    Perez, Andre

    2013-01-01

    This book explains the evolutions of architecture for mobiles and summarizes the different technologies:- 2G: the GSM (Global System for Mobile) network, the GPRS (General Packet Radio Service) network and the EDGE (Enhanced Data for Global Evolution) evolution;- 3G: the UMTS (Universal Mobile Telecommunications System) network and the HSPA (High Speed Packet Access) evolutions:- HSDPA (High Speed Downlink Packet Access),- HSUPA (High Speed Uplink Packet Access),- HSPA+;- 4G: the EPS (Evolved Packet System) network.The telephone service and data transmission are the

  17. Microgrids architectures and control

    CERN Document Server

    Hatziargyriou, Nikos

    2014-01-01

    Microgrids are the most innovative area in the electric power industry today. Future microgrids could exist as energy-balanced cells within existing power distribution grids or stand-alone power networks within small communities. A definitive presentation on all aspects of microgrids, this text examines the operation of microgrids - their control concepts and advanced architectures including multi-microgrids. It takes a logical approach to overview the purpose and the technical aspects of microgrids, discussing the social, economic and environmental benefits to power system operation. The bo

  18. Advanced router architectures

    CERN Document Server

    Kloth, Axel K

    2005-01-01

    Routers, switches, and transmission equipment form the backbone of the Internet, yet many users and service technicians do not understand how these nodes really work.Advanced Router Architectures addresses how components of advanced routers work together and how they are integrated with each other. This book provides the background behind why these building blocks perform certain functions, and how the function is implemented in general use. It offers an introduction to the subject matter that is intended to trigger deeper interest from the reader. The book explains, for example, why traffic m

  19. Light Rhythms in Architecture

    DEFF Research Database (Denmark)

    Bülow, Katja

    2013-01-01

    On one hand, urban lighting expresses itself in a complex visual environment made by the interplay by between many separate lighting schemes, as street lighting, shop lighting, luminous commercials etc. On the other, a noticeable order of patterns occurs, when lighting is observed as luminous...... formation and rhythm. When integrated into an architectural concept, electrical lighting non-intended for poetic composition has the ability to contribute to place, time, and function-telling aspects of places in urban contexts. Urban environments are information wise challenging to pre-historic human...... instincts, but they can be met by careful selection and adjustment of existing light situations....

  20. Between Organisation and Architecture

    DEFF Research Database (Denmark)

    Stang Våland, Marianne

    2011-01-01

    . In this process, the open-office layout was introduced as a premediated design condition, a format that the users initially resisted. The paper discusses how end-user participation as a method and spatial design as a perspective may inform change in organisations. Although the users' resistance toward the open......This paper contributes to our sparse knowledge on the relationship between organisational and architectural design. It is based on an ethnographic study of the process of designing a municipality town hall, in which end-user participation constituted an integrated part of the design process...

  1. Future of information architecture

    CERN Document Server

    Baofu, Peter

    2008-01-01

    The Future of Information Architecture examines issues surrounding why information is processed, stored and applied in the way that it has, since time immemorial. Contrary to the conventional wisdom held by many scholars in human history, the recurrent debate on the explanation of the most basic categories of information (eg space, time causation, quality, quantity) has been misconstrued, to the effect that there exists some deeper categories and principles behind these categories of information - with enormous implications for our understanding of reality in general. To understand this, the b

  2. EXPLORATION ENGINEERING

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>20142564Chen Mingxing(Beijing Research Institute of Survey and Design,China Hydropower Engineering Consulting Group Co.,Beijing 100024,China);Chen Baoguo Application of Drilling Deviation Correcting and Deflecting Techniques in Geological Exploration at Songta Hydropower Station(Exploration Engineering,ISSN1672-7428,CN11-5063/TD,

  3. Architectural Theory: A Construction Site

    Directory of Open Access Journals (Sweden)

    Ákos Moravánszky

    2014-07-01

    Full Text Available Around 1968 we saw the birth of a new architectural theory as the conjunction of architectural history and politically engaged architectural criticism. Not the aesthetics of architecture, but architecture itself in its structural relations with social life became the focus of attention. As a result of this development, it is no longer possible to study architectural history without a critical reflection on the method of the study itself and without a grade of interdisciplinarity. Traditional methods of historiography and iconography have been replaced by new approaches configured by psychoanalysis, deconstruction, cultural studies etc. Appropriation has become the proof of criticality both in architectural theory and in design; however, the understanding of the concepts and methods of other disciplines is basically metaphorical. The problem for a school of architecture lies not in the ‘criticality’ of the kind of architectural theory we described as emerging from the spirit of 1968, but in its discursive nature. The disciplinary specificity of architecture resists a discursive approach, and architectural students frequently question the usefulness of theory which undermines the notion of the ‘project’, without articulating a constructive proposal. Projectivity does not seem to provide an answer; its claim of performativity lacks the program to regain its organising power over contributions from other specialised disciplines and practices. Theory should focus on the terms of our discipline, which are so close to our ‘core beliefs’ regarding architecture that we usually take their meaning for granted. It would be wrong to see this focus of theory as a withdrawal into the realm of language. Indeed, after a period of theory alienating architects and the general public, it could now create a rhetoric to influence our understanding of our environment, which is itself organised on the level of language. The requirement that theory should

  4. Architecture in the network society

    DEFF Research Database (Denmark)

    2004-01-01

    Under the theme Architecture in the Network Society, participants were invited to focus on the dialog and sharing of knowledge between architects and other disciplines and to reflect on, and propose, new methods in the design process, to enhance and improve the impact of information technology...... on architecture. This conference and the past history of eCAADe is an example on establishing a social network for the sharing of knowledge regarding the use of computers in architectural education and research....

  5. Contemporary earthen architecture in Mexico

    OpenAIRE

    Aguilar Prieto, Berenice

    2009-01-01

    The purpose of this study is to put forward an appraisal of current remarkable works of earthen architecture in Mexico, where raw earth architecture, particularly in adobe, has been built since ancient times, but has nevertheless, been substituted by industrial materials that bring poor living conditions for the inhabitants both in urban as in rural areas. Recently, rather than vernacular architecture built by its users, it is within architectonic design that a kind of revival ...

  6. Towards a networkArchitecture

    DEFF Research Database (Denmark)

    Rüdiger, Bjarne; Tournay, Bruno

    2001-01-01

    Planche, bidrag til DAL-konkurrencen. Hvor industrien har været inspirationen for udviklingen af den moderne arkitektur, er IT det tekniske og æstetiske grundlag for den spirende NetworkArchitecture. Computeren og netværker af computerne er således mere end en metafor for NetworkArchitecture....... NetworkArchitecture består af intelligente byggekomponenter forbundet med hinanden i et netværk og i interaktion med omgivelser....

  7. A Dual Launch Robotic and Human Lunar Mission Architecture

    Science.gov (United States)

    Jones, David L.; Mulqueen, Jack; Percy, Tom; Griffin, Brand; Smitherman, David

    2010-01-01

    This paper describes a comprehensive lunar exploration architecture developed by Marshall Space Flight Center's Advanced Concepts Office that features a science-based surface exploration strategy and a transportation architecture that uses two launches of a heavy lift launch vehicle to deliver human and robotic mission systems to the moon. The principal advantage of the dual launch lunar mission strategy is the reduced cost and risk resulting from the development of just one launch vehicle system. The dual launch lunar mission architecture may also enhance opportunities for commercial and international partnerships by using expendable launch vehicle services for robotic missions or development of surface exploration elements. Furthermore, this architecture is particularly suited to the integration of robotic and human exploration to maximize science return. For surface operations, an innovative dual-mode rover is presented that is capable of performing robotic science exploration as well as transporting human crew conducting surface exploration. The dual-mode rover can be deployed to the lunar surface to perform precursor science activities, collect samples, scout potential crew landing sites, and meet the crew at a designated landing site. With this approach, the crew is able to evaluate the robotically collected samples to select the best samples for return to Earth to maximize the scientific value. The rovers can continue robotic exploration after the crew leaves the lunar surface. The transportation system for the dual launch mission architecture uses a lunar-orbit-rendezvous strategy. Two heavy lift launch vehicles depart from Earth within a six hour period to transport the lunar lander and crew elements separately to lunar orbit. In lunar orbit, the crew transfer vehicle docks with the lander and the crew boards the lander for descent to the surface. After the surface mission, the crew returns to the orbiting transfer vehicle for the return to the Earth. This

  8. The ALMA software architecture

    Science.gov (United States)

    Schwarz, Joseph; Farris, Allen; Sommer, Heiko

    2004-09-01

    The software for the Atacama Large Millimeter Array (ALMA) is being developed by many institutes on two continents. The software itself will function in a distributed environment, from the 0.5-14 kmbaselines that separate antennas to the larger distances that separate the array site at the Llano de Chajnantor in Chile from the operations and user support facilities in Chile, North America and Europe. Distributed development demands 1) interfaces that allow separated groups to work with minimal dependence on their counterparts at other locations; and 2) a common architecture to minimize duplication and ensure that developers can always perform similar tasks in a similar way. The Container/Component model provides a blueprint for the separation of functional from technical concerns: application developers concentrate on implementing functionality in Components, which depend on Containers to provide them with services such as access to remote resources, transparent serialization of entity objects to XML, logging, error handling and security. Early system integrations have verified that this architecture is sound and that developers can successfully exploit its features. The Containers and their services are provided by a system-orienteddevelopment team as part of the ALMA Common Software (ACS), middleware that is based on CORBA.

  9. The role Sustainable Architecture in Iranian Traditional Architecture

    Directory of Open Access Journals (Sweden)

    Shabnam Azadi

    2016-12-01

    Full Text Available Using local and continental materials, Sustainable architecture aims to design sustainable buildings, decrease its damages to the environment, sources of energy and nature. A deeper thought on the principles of traditional architecture indicates that the idea of constancy has its origins back in ancient human norms. On the one hand, solving the environmental, cultural-social and economic problems, and the intense integrity of such issues, direct us toward traditional architecture and constancy in comparison and evaluation in order to extract the required lessons for today’s architectural design. On the other hand, the historical architectural and urbanization evidence reveals that in the past, architecture and urbanization have taken place in line with the environment, traditional architecture with a tendency to environmental and social constancy and with respect to natural resources and preserving them for the future generations. Nowadays, unlimited destruction of the environment which is due to the malicious attitude toward nature in the recent centuries, threatens human life. The sudden stop in the creative process of past architecture, and the faster and easier solutions by modern architects have made forget the methods which were appropriate with the environment. In this article, traditional Iranian houses were studied in this sense in order to have looked at the traditional architecture with open eyes and to use its intellectual background in today’s architecture and building techniques. Finally, in this research the reasons for constancy of Iranian traditional houses were investigated with a descriptiveanalytic approach and strategies are suggested with respect to new technology with the purpose of preserving traditional local architecture which causes sustainable development of the houses.

  10. Sustainability and the Architectural History

    Directory of Open Access Journals (Sweden)

    Vandana Baweja

    2014-12-01

    Full Text Available In this paper, I will address the challenges of incorporating the discourse of Sustainability into the architectural history curriculum and how Sustainability in the survey can be related to the Sustainability education the design studio. I argue that the inclusion of Sustainability into the architectural survey will necessitate the production of revisionist architectural histories that are written through an environmental paradigm and are able to establish a dialogue with Sustainability education in the design studio. These revisionist histories will occupy the disciplinary territory that is produced at the intersection of architectural and environmental histories

  11. Integrated Data Assimilation Architecture Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Integrated Data Assimilation Architecture (IDAA) addresses the fundamental problem of command, control, and communications systems interoperability....

  12. Mapping a classification system to architectural education

    DEFF Research Database (Denmark)

    Hermund, Anders; Klint, Lars; Rostrup, Nicolai

    2015-01-01

    This paper examines to what extent a new classification system, Cuneco Classification System, CCS, proves useful in the education of architects, and to what degree the aim of an architectural education, rather based on an arts and crafts approach than a polytechnic approach, benefits from...... the distinct terminology of the classification system. The method used to examine the relationship between education, practice and the CCS bifurcates in a quantitative and a qualitative exploration: Quantitative comparison of the curriculum with the students’ own descriptions of their studies through...

  13. Dendronized Polymer Architectures for Fuel Cell Membranes

    DEFF Research Database (Denmark)

    Nielsen, Mads Møller; Dimitrov, Ivaylo; Takamuku, S.

    2013-01-01

    Multi‐step synthetic pathways to low‐ion exchange capacity (IEC) polysulfone (PSU) with sulfonic acid functionalized aliphatic dendrons and sulfonated comb‐type PSU structures are developed and investigated in a comparative study as non‐fluorinated proton exchange membrane (PEM) candidates. In each...... evaluated as PEMs for use in fuel cells by proton conductivity measurements, and in the case of dendronized architectures: thermal stability. The proposed synthetic strategy facilitates exploration of a non‐fluorous system with various flexible side chains where IEC is tunable by the degree of substitution....

  14. Reframing textiles into architectural systems: Construction of a membrane shell by patchwork

    NARCIS (Netherlands)

    Vrouwe, I.; Feijen, M.; Houtnam, R.; Borgart, A.

    2011-01-01

    In this paper different qualities of architectural textile techniques and tectonics are explored. By using a reframing strategy micro techniques and tectonics as used in fashion and textile design are evolved into an architectural scale. To reveal the quality of this reframing procedure a case scena

  15. Applying the V Model and Axiomatic Design in the Domain of IT Architecture Practice

    NARCIS (Netherlands)

    Tarenskeen, Debbie; Bakker, René; Joosten, Stef

    2015-01-01

    This paper applies and discusses the principles of Axiomatic Design for changing IT architecture in health care. It presents three case studies positioned in the field of Enterprise architecture that explore how IT architects, as professionals, manage change and re-design the structure of the IT sys

  16. A reconfigurable function array architecture for 3G and 4G wireless terminals

    NARCIS (Netherlands)

    Heysters, Paul M.; Bouma, Henri; Smit, Jaap; Smit, Gerard J.M.

    2002-01-01

    Advance in low-power hand-held multimedia systems requires exploration of novel system architectures. In conventional computer architectures, an increase in processing power also implies an increase in energy consumption. In a mobile system this results in a shorter operating-time. Limiting the gene

  17. ARCHITECTURAL LARGE CONSTRUCTED ENVIRONMENT. MODELING AND INTERACTION USING DYNAMIC SIMULATIONS

    Directory of Open Access Journals (Sweden)

    P. Fiamma

    2012-09-01

    Full Text Available How to use for the architectural design, the simulation coming from a large size data model? The topic is related to the phase coming usually after the acquisition of the data, during the construction of the model and especially after, when designers must have an interaction with the simulation, in order to develop and verify their idea. In the case of study, the concept of interaction includes the concept of real time "flows". The work develops contents and results that can be part of the large debate about the current connection between "architecture" and "movement". The focus of the work, is to realize a collaborative and participative virtual environment on which different specialist actors, client and final users can share knowledge, targets and constraints to better gain the aimed result. The goal is to have used a dynamic micro simulation digital resource that allows all the actors to explore the model in powerful and realistic way and to have a new type of interaction in a complex architectural scenario. On the one hand, the work represents a base of knowledge that can be implemented more and more; on the other hand the work represents a dealt to understand the large constructed architecture simulation as a way of life, a way of being in time and space. The architectural design before, and the architectural fact after, both happen in a sort of "Spatial Analysis System". The way is open to offer to this "system", knowledge and theories, that can support architectural design work for every application and scale. We think that the presented work represents a dealt to understand the large constructed architecture simulation as a way of life, a way of being in time and space. Architecture like a spatial configuration, that can be reconfigurable too through designing.

  18. Architecture of Institution & Home. Architecture as Cultural Medium

    NARCIS (Netherlands)

    Robinson, J.W.

    2004-01-01

    This dissertation addresses how architecture functions as a cultural medium. It does so by by investigating how the architecture of institution and home each construct and support different cultural practices. By studying the design of ordinary settings in terms of how qualitative differences in arc

  19. Software architecture as a set of architectural design decisions

    NARCIS (Netherlands)

    Jansen, Anton; Bosch, Jan; Nord, R; Medvidovic, N; Krikhaar, R; Khrhaar, R; Stafford, J; Bosch, J

    2006-01-01

    Software architectures have high costs for change, are complex, and erode during evolution. We believe these problems are partially due to knowledge vaporization. Currently, almost all the knowledge and information about the design decisions the architecture is based on are implicitly embedded in th

  20. Architectures Toward Reusable Science Data Systems

    Science.gov (United States)

    Moses, J. F.

    2014-12-01

    Science Data Systems (SDS) comprise an important class of data processing systems that support product generation from remote sensors and in-situ observations. These systems enable research into new science data products, replication of experiments and verification of results. NASA has been building ground systems for satellite data processing since the first Earth observing satellites launched and is continuing development of systems to support NASA science research, NOAA's weather satellites and USGS's Earth observing satellite operations. The basic data processing workflows and scenarios continue to be valid for remote sensor observations research as well as for the complex multi-instrument operational satellite data systems being built today. System functions such as ingest, product generation and distribution need to be configured and performed in a consistent and repeatable way with an emphasis on scalability. This paper will examine the key architectural elements of several NASA satellite data processing systems currently in operation and under development that make them suitable for scaling and reuse. Examples of architectural elements that have become attractive include virtual machine environments, standard data product formats, metadata content and file naming, workflow and job management frameworks, data acquisition, search, and distribution protocols. By highlighting key elements and implementation experience the goal is to recognize architectures that will outlast their original application and be readily adaptable for new applications. Concepts and principles are explored that lead to sound guidance for SDS developers and strategists.

  1. Conveying Architectural Form and Space with Virtual Reality

    DEFF Research Database (Denmark)

    Kreutzberg, Anette

    2015-01-01

    The purpose of this study was to explore the user experience of non-specialists viewing and navigating in an architectural native (Revit) BIM model in Virtual Reality (VR) with a head mounted display (HMD). The perceived sense of presence as well as the quality of vision and total VR experience...

  2. First Workshop on Sharing and Reusing Architectural Knowledge

    NARCIS (Netherlands)

    Lago, Patricia; Avgeriou, Paris

    2006-01-01

    The first SHARK (SHAring and Reusing architectural Knowledge) workshop, attempted to explore the state of the art as well as the state of the practice in this emerging field. This workshop report presents the themes of the workshop, it summarizes the results of the discussions held about various top

  3. Long-term Behavior of Serous Borderline Tumors Subdivided Into Atypical Proliferative Tumors and Noninvasive Low-grade Carcinomas

    DEFF Research Database (Denmark)

    Vang, Russell; Hannibal, Charlotte Gerd; Junge, Jette

    2017-01-01

    Ovarian serous borderline tumors (SBTs) have been the subject of considerable controversy, particularly with regard to terminology and behavior. It has been proposed that they constitute a heterogenous group of tumors composed, for the most part, of typical SBTs that are benign and designated...... "atypical proliferative serous tumor (APST)" and a small subset of SBTs with micropapillary architecture that have a poor outcome and are designated "noninvasive low-grade serous carcinoma (niLGSC)". It also has been argued that the difference in behavior between the 2 groups is not due to the subtype...... of the primary tumor but rather the presence of extraovarian disease, specifically invasive implants. According to the terminology of the 2014 WHO Classification, typical SBTs are equivalent to APSTs and SBTs displaying micropapillary architecture are synonymous with niLGSC. In addition, "invasive implants" were...

  4. The Architecture of Exoplanets

    Science.gov (United States)

    Hatzes, Artie P.

    2016-05-01

    Prior to the discovery of exoplanets our expectations of their architecture were largely driven by the properties of our solar system. We expected giant planets to lie in the outer regions and rocky planets in the inner regions. Planets should probably only occupy orbital distances 0.3-30 AU from the star. Planetary orbits should be circular, prograde and in the same plane. The reality of exoplanets have shattered these expectations. Jupiter-mass, Neptune-mass, Superearths, and even Earth-mass planets can orbit within 0.05 AU of the stars, sometimes with orbital periods of less than one day. Exoplanetary orbits can be eccentric, misaligned, and even in retrograde orbits. Radial velocity surveys gave the first hints that the occurrence rate increases with decreasing mass. This was put on a firm statistical basis with the Kepler mission that clearly demonstrated that there were more Neptune- and Superearth-sized planets than Jupiter-sized planets. These are often in multiple, densely packed systems where the planets all orbit within 0.3 AU of the star, a result also suggested by radial velocity surveys. Exoplanets also exhibit diversity along the main sequence. Massive stars tend to have a higher frequency of planets ( ≈ 20-25 %) that tend to be more massive ( M≈ 5-10 M_{Jup}). Giant planets around low mass stars are rare, but these stars show an abundance of small (Neptune and Superearth) planets in multiple systems. Planet formation is also not restricted to single stars as the Kepler mission has discovered several circumbinary planets. Although we have learned much about the architecture of planets over the past 20 years, we know little about the census of small planets at relatively large ( a>1 AU) orbital distances. We have yet to find a planetary system that is analogous to our own solar system. The question of how unique are the properties of our own solar system remains unanswered. Advancements in the detection methods of small planets over a wide range

  5. The Architecture of Exoplanets

    Science.gov (United States)

    Hatzes, Artie P.

    2016-12-01

    Prior to the discovery of exoplanets our expectations of their architecture were largely driven by the properties of our solar system. We expected giant planets to lie in the outer regions and rocky planets in the inner regions. Planets should probably only occupy orbital distances 0.3-30 AU from the star. Planetary orbits should be circular, prograde and in the same plane. The reality of exoplanets have shattered these expectations. Jupiter-mass, Neptune-mass, Superearths, and even Earth-mass planets can orbit within 0.05 AU of the stars, sometimes with orbital periods of less than one day. Exoplanetary orbits can be eccentric, misaligned, and even in retrograde orbits. Radial velocity surveys gave the first hints that the occurrence rate increases with decreasing mass. This was put on a firm statistical basis with the Kepler mission that clearly demonstrated that there were more Neptune- and Superearth-sized planets than Jupiter-sized planets. These are often in multiple, densely packed systems where the planets all orbit within 0.3 AU of the star, a result also suggested by radial velocity surveys. Exoplanets also exhibit diversity along the main sequence. Massive stars tend to have a higher frequency of planets (≈ 20-25 %) that tend to be more massive (M≈ 5-10 M_{Jup}). Giant planets around low mass stars are rare, but these stars show an abundance of small (Neptune and Superearth) planets in multiple systems. Planet formation is also not restricted to single stars as the Kepler mission has discovered several circumbinary planets. Although we have learned much about the architecture of planets over the past 20 years, we know little about the census of small planets at relatively large (a>1 AU) orbital distances. We have yet to find a planetary system that is analogous to our own solar system. The question of how unique are the properties of our own solar system remains unanswered. Advancements in the detection methods of small planets over a wide range of

  6. Lung Carcinoid Tumor: Surgery

    Science.gov (United States)

    ... Disease Lung Carcinoid Tumor Treating Lung Carcinoid Tumors Surgery to Treat Lung Carcinoid Tumors Surgery is the ... be cured by surgery alone. Types of lung surgery Different operations can be used to treat (and ...

  7. Tumors and Pregnancy

    Science.gov (United States)

    Tumors during pregnancy are rare, but they can happen. Tumors can be either benign or malignant. Benign tumors aren't cancer. Malignant ones are. The most common cancers in pregnancy are breast cancer, cervical cancer, lymphoma, and melanoma. ...

  8. Neuroendocrine Tumor: Statistics

    Science.gov (United States)

    ... Tumor > Neuroendocrine Tumor: Statistics Request Permissions Neuroendocrine Tumor: Statistics Approved by the Cancer.Net Editorial Board , 11/ ... the body. It is important to remember that statistics on how many people survive this type of ...

  9. Brain Tumors (For Parents)

    Science.gov (United States)

    ... Old Feeding Your 1- to 2-Year-Old Brain Tumors KidsHealth > For Parents > Brain Tumors Print A ... radiation therapy or chemotherapy, or both. Types of Brain Tumors There are many different types of brain ...

  10. Childhood Brain Tumors

    Science.gov (United States)

    Brain tumors are abnormal growths inside the skull. They are among the most common types of childhood ... still be serious. Malignant tumors are cancerous. Childhood brain and spinal cord tumors can cause headaches and ...

  11. Renal Tumor

    Directory of Open Access Journals (Sweden)

    Yarisdey Corrales Hernández

    2016-02-01

    Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;}

  12. GEOPHYSICAL EXPLORATION

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>20141074Bao Xijie(Research Institute of Exploration and Development,Daqing Oilfield Company,PetroChina,Daqing 163712,China)Gather Optimal Processing and Application Effect of Prestack AVA Instantaneous Inversion

  13. High-Tech Architecture

    Directory of Open Access Journals (Sweden)

    Özlem Eşsiz

    1999-05-01

    Full Text Available The technological development in building and construction area, bring with the new construction systems and the new products. The aim of this study is to define the High Tech concept, and set the common and basic characteristics of High Tech applications. During 1970’s High Tech was born and developed in Britain. Especially British Architects Richard Rogers, Michael Hopkins, Norman Foster, Nicholas Grimshaw and Ian Ritchie are the leaders of this style. Their architecture show the machine aesthetic and use of industrial revoluation materials such as glass and steel. The reasons for wide usage of this technology in building constructions are; the ease of renewing the structural and installation systems by the changing technology and giving monumentality to the prestige buildings. High Tech building which we have many examples of give their occupants a lot of opportunities and also they can adapt itself to the time.

  14. Architecture for Teraflop Visualization

    Energy Technology Data Exchange (ETDEWEB)

    Breckenridge, A.R.; Haynes, R.A.

    1999-04-09

    Sandia Laboratories' computational scientists are addressing a very important question: How do we get insight from the human combined with the computer-generated information? The answer inevitably leads to using scientific visualization. Going one technology leap further is teraflop visualization, where the computing model and interactive graphics are an integral whole to provide computing for insight. In order to implement our teraflop visualization architecture, all hardware installed or software coded will be based on open modules and dynamic extensibility principles. We will illustrate these concepts with examples in our three main research areas: (1) authoring content (the computer), (2) enhancing precision and resolution (the human), and (3) adding behaviors (the physics).

  15. Thermal Space in Architecture

    DEFF Research Database (Denmark)

    Petersen, Mads Dines

    buildings. However at the bottom of this lies an understanding of how we inhabit the space in our buildings and how we historically have adapted to the changing conditions of the seasons in our buildings. Through an increased understanding of this adaptability of and to our buildings, our work with spaces...... and understanding of spaces in buildings can change significantly and instead of the creation of frozen geometrical spaces, thermal spaces can be created as it is suggested in meteorological architecture where functions are distributed in relation to temperature gradients. This creates an interesting contrast...... to the current discussions about passive houses that today is starting to set the standards in a Scandinavian context, where the highly controlled indoor environment is in focus relying on mechanical ventilation, creating spaces with a narrow margin for comfort. One can raise the question if re...

  16. Mobile Remote Control Architecture

    Directory of Open Access Journals (Sweden)

    George Stefan Bogdan

    2012-03-01

    Full Text Available When mobile device become more and more popular the need to have a software bridge between them and the old fashioned computers became evident. Many different solutions have appeared to fill the void but few offer more than file sinking or remote SSH (secure shell connections. For computer professionals and other alike a tool that can do more regarding this connectivity and control gap became necessary. With this paper it is described an architecture and an implementation for creating such a system, underlining the difficulties, challenges and the many choices regarding overall system design, security and implementation that need to be made in order to provide the user with a secure, reliable and professional solution.

  17. Architectural Practice as Research

    DEFF Research Database (Denmark)

    Hougaard, Anna Katrine

    2015-01-01

    , qualitative and quantitative, scientific and artistic methods pollinate each other, and an attempt to set up a span for ‘research by design’ to unfold in, rather than a rigid definition. In mutual exploitation architectural writing, drawing and potentially the construction of objects with properties embodied......The paper discusses a kind of research which lies between ‘research by design’ and ‘artistic research’. The term ‘research by design’ is reconstructed to include artistic ways of working, and the paper is an exemplification of a research practice, which seeks to let subjective and objective...... in them, is the very research. This approach is framed by Deleuze’s reading of Bergson’s intuitive method and Peirce’s concept abduction, both methods which concern creative processes, material production and organisation, and the breakthrough of novelty....

  18. Architectural Competition and BIM

    DEFF Research Database (Denmark)

    Sørensen, Nils Lykke; Frandsen, Anne Kathrine; Øien, Turid Borgestrand

    2015-01-01

    put under pressure. Thus, the two central actors involved inarchitectural competitions, architects and building clients, are continually influenced by such developments, interpreting and adaptingto changes according to their interests and horizons. During a project reviewing Nordic research literature...... on architecturalcompetitions, a series of interviews was conducted with building clients as well as architects, focusing on the impact of the above-mentioned changes within the building sector on architectural competitions as an institution. In the interviews, ICT and notleast BIM was a recurring theme that both parties saw...... as having a positive impact on competitions. But when looking closely into the answers, these revealed diverse understandings of how and why the impact of BIM on competitions could be said to be positive. The paper sheds light on the interaction between the actors (building clients, architects and client...

  19. Architecture, energy and climate

    DEFF Research Database (Denmark)

    Lauring, Michael

    2010-01-01

    Architecture has always had to relate to climatic conditions while providing shelter from the sun, the rain, the winds or the cold. This is a main purpose of buildings: To establish an indoor climate different from the outdoor. In the Nordic countries fuels for heating buildings has been a vital...... necessity almost as basic as food and water, and lack of wood has caused illness and migration - scarcity of energy is not a new topic either [Kjærgaard]. The new aspects are that human civilization is in danger of causing severe global climate changes, secondly that we can foresee using up the global non......-renewable reserves of oil, gas and uranium, both aspects capable of pulling the carpet under human civilization itself as we know it. The huge energy consumption especially in the northern hemisphere is closely linked to industrialization, and the response from those aware of energy and climate problems has in some...

  20. Multimedia communications: architectural alternatives

    Science.gov (United States)

    McGarty, Terrence P.; Treves, S. T.

    1992-03-01

    Multimedia communications systems are a combination of human interfaces and end users interacting with multimedia data bases and highly disparate but interconnected communications networks. This paper discusses several architectural alternatives and system requirements that will assist in the design and development of MMCS in actual environments. The approaches taken in this paper are based upon the development of such systems in both medical and printing and publishing environments. This paper develops several key concepts as how best to define and structure data in a multimedia environment, how best to integrate the communications elements, and how best to permit the maximum flexibility to the end user to utilize the system's capabilities in the context of a fully conversational environment.