WorldWideScience

Sample records for architecture as topic

  1. Distributed search engine architecture based on topic specific searches

    Science.gov (United States)

    Abudaqqa, Yousra; Patel, Ahmed

    2015-05-01

    Indisputably, search engines (SEs) abound. The monumental growth of users performing online searches on the Web is a contending issue in the contemporary world nowadays. For example, there are tens of billions of searches performed everyday, which typically offer the users many irrelevant results which are time consuming and costly to the user. Based on the afore-going problem it has become a herculean task for existing Web SEs to provide complete, relevant and up-to-date information response to users' search queries. To overcome this problem, we developed the Distributed Search Engine Architecture (DSEA), which is a new means of smart information query and retrieval of the World Wide Web (WWW). In DSEAs, multiple autonomous search engines, owned by different organizations or individuals, cooperate and act as a single search engine. This paper includes the work reported in this research focusing on development of DSEA, based on topic-specific specialised search engines. In DSEA, the results to specific queries could be provided by any of the participating search engines, for which the user is unaware of. The important design goal of using topic-specific search engines in the research is to build systems that can effectively be used by larger number of users simultaneously. Efficient and effective usage with good response is important, because it involves leveraging the vast amount of searched data from the World Wide Web, by categorising it into condensed focused topic -specific results that meet the user's queries. This design model and the development of the DSEA adopt a Service Directory (SD) to route queries towards topic-specific document hosting SEs. It displays the most acceptable performance which is consistent with the requirements of the users. The evaluation results of the model return a very high priority score which is associated with each frequency of a keyword.

  2. Topical peptides as cosmeceuticals

    Directory of Open Access Journals (Sweden)

    Varadraj Vasant Pai

    2017-01-01

    Full Text Available Peptides are known to have diverse biological roles, most prominently as signaling/regulatory molecules in a broad variety of physiological processes including defense, immunity, stress, growth, homeostasis and reproduction. These aspects have been used in the field of dermatology and cosmetology to produce short, stable and synthetic peptides for extracellular matrix synthesis, pigmentation, innate immunity and inflammation. The evolution of peptides over the century, which started with the discovery of penicillin, has now extended to their usage as cosmeceuticals in recent years. Cosmeceutical peptides may act as signal modulators of the extracellular matrix component, as structural peptides, carrier peptides and neurotransmitter function modulators. Transdermal delivery of peptides can be made more effective by penetration enhancers, chemical modification or encapsulation of peptides. The advantages of using peptides as cosmeceuticals include their involvement in many physiological functions of the skin, their selectivity, their lack of immunogenicity and absence of premarket regulatory requirements for their use. However, there are disadvantages: clinical evidence for efficacy is often weak, absorption may be poor due to low lipophilicity, high molecular weight and binding to other ingredients, and prices can be quite high.

  3. Architecture as Design Study.

    Science.gov (United States)

    Kauppinen, Heta

    1989-01-01

    Explores the use of analogies in architectural design, the importance of Gestalt theory and aesthetic cannons in understanding and being sensitive to architecture. Emphasizes the variation between public and professional appreciation of architecture. Notes that an understanding of architectural process enables students to improve the aesthetic…

  4. Architecture as liminal Space

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    Nilly Harag

    2015-11-01

    Full Text Available The point of departure of the architectural project has to stem from the combination of inner and outer journeys in between the real or imagined limits. The pressing challenge is to destabilize the neat division of architecture into separate bodies of knowledge and pose the architect’s mode of action on the threshold between the concrete and the universal. Architecture is a lens, an instrument one looks through to bring new perspectives into focus, enabling the transformation of experience from a magnified self-concentrated space to a wide horizon. Architecture narrates relations between spaces and examines its validity through signifying practices of design. Design for itself becomes the language of the current, of the immediate fashion. Architecture can fulfill peoples’ dreams and miraculously can provide them tools to invent new ones: Curiosity is the first motive to act.

  5. Architecture as Ars Combinatoria

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    Francesco Cacciatore

    2015-11-01

    Full Text Available Architecture today, no longer reflects the limits of experimentation and innovation. An extremely low-tech art whose field of possibilities consists of choosing and using that which has already been done in the past. It is because of this that the key skill a designer should have is the ability to recognize the complexity in forms around them: cities have the widest programming opportunities for architecture, in the two-way relationship that is established from the city that takes form in architecture and an architecture that finds its place in the contemporary city. Thus, architecture has its foundation in hospitality, an element that differentiates it significantly from the design.

  6. Architecture as Ars Combinatoria

    OpenAIRE

    Francesco Cacciatore

    2015-01-01

    Architecture today, no longer reflects the limits of experimentation and innovation. An extremely low-tech art whose field of possibilities consists of choosing and using that which has already been done in the past. It is because of this that the key skill a designer should have is the ability to recognize the complexity in forms around them: cities have the widest programming opportunities for architecture, in the two-way relationship that is established from the city that takes form in arc...

  7. On minimalism in architecture - space as experience

    Directory of Open Access Journals (Sweden)

    Vasilski Dragana

    2016-01-01

    Full Text Available Architecture has to be experienced to be understood. The complexity of the experience is seen through a better understanding of the relationship between objectivity (architecture and subjectivity (our life. Being physically, emotionally and psychologically aware of the space we occupy is an experience that could be described as being present, which is a sensation that is personal and difficult to explicitly describe. Research into experience through perception and emotion positions architecture within scientific fields, in particular psychological disciplines. Relying on the standpoints of Immanuel Kant, the paper considers the juxtaposition between (minimalism in architecture and philosophy on the topic of experience. Starting from the basic aspects of perception and representation of the world around us, a thesis is presented in which the notions of silence and light as experienced in minimalism (in architecture are considered as adequate counterparts to Kant’s factors of experience - the awareness of the objective order of events and the impossibility to perceive time itself. Through a case study we verify the starting hypothesis on minimalism (in architecture whereby space becomes an experience of how the world touches us.

  8. Architectural Practice as Research

    DEFF Research Database (Denmark)

    Hougaard, Anna Katrine

    2015-01-01

    , qualitative and quantitative, scientific and artistic methods pollinate each other, and an attempt to set up a span for ‘research by design’ to unfold in, rather than a rigid definition. In mutual exploitation architectural writing, drawing and potentially the construction of objects with properties embodied......The paper discusses a kind of research which lies between ‘research by design’ and ‘artistic research’. The term ‘research by design’ is reconstructed to include artistic ways of working, and the paper is an exemplification of a research practice, which seeks to let subjective and objective...... in them, is the very research. This approach is framed by Deleuze’s reading of Bergson’s intuitive method and Peirce’s concept abduction, both methods which concern creative processes, material production and organisation, and the breakthrough of novelty....

  9. Network architecture as internet governance

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    Francesca Musiani

    2013-10-01

    Full Text Available The architecture of a networked system is its underlying technical and logical structure, including transmission equipment, communication protocols, infrastructure, and connectivity between its components or nodes. This article introduces the idea of network architecture as internet governance, and more specifically, it outlines the dialectic between centralised and distributed architectures, institutions and practices, and how they mutually affect each other. The article argues that network architecture is internet governance in the sense that, by changing the design of the networks subtending internet-based services and the global internet itself, its politics are affected – the balance of rights between users and providers, the capacity of online communities to engage in open and direct interaction, the fair competition between actors of the internet market.

  10. Topical and peripheral ketamine as an analgesic.

    Science.gov (United States)

    Sawynok, Jana

    2014-07-01

    Ketamine, in subanesthetic doses, produces systemic analgesia in chronic pain settings, an action largely attributed to block of N-methyl-D-aspartate receptors in the spinal cord and inhibition of central sensitization processes. N-methyl-D-aspartate receptors also are located peripherally on sensory afferent nerve endings, and this provided the initial impetus for exploring peripheral applications of ketamine. Ketamine also produces several other pharmacological actions (block of ion channels and receptors, modulation of transporters, anti-inflammatory effects), and while these may require higher concentrations, after topical (e.g., as gels, creams) and peripheral application (e.g., localized injections), local tissue concentrations are higher than those after systemic administration and can engage lower affinity mechanisms. Peripheral administration of ketamine by localized injection produced some alterations in sensory thresholds in experimental trials in volunteers and in complex regional pain syndrome subjects in experimental settings, but many variables were unaltered. There are several case reports of analgesia after topical application of ketamine given alone in neuropathic pain, but controlled trials have not confirmed such effects. A combination of topical ketamine with several other agents produced pain relief in case, and case series, reports with response rates of 40% to 75% in retrospective analyses. In controlled trials of neuropathic pain with topical ketamine combinations, there were improvements in some outcomes, but optimal dosing and drug combinations were not clear. Given orally (as a gargle, throat swab, localized peritonsillar injections), ketamine produced significant oral/throat analgesia in controlled trials in postoperative settings. Topical analgesics are likely more effective in particular conditions (patient factors, disease factors), and future trials of topical ketamine should include a consideration of factors that could predispose

  11. Architecture of Institution & Home. Architecture as Cultural Medium

    NARCIS (Netherlands)

    Robinson, J.W.

    2004-01-01

    This dissertation addresses how architecture functions as a cultural medium. It does so by by investigating how the architecture of institution and home each construct and support different cultural practices. By studying the design of ordinary settings in terms of how qualitative differences in arc

  12. Education architecture as a sensorium

    DEFF Research Database (Denmark)

    Juelskjær, Malou

    , you may set up the condition for students to ‘desire’ learning, in order to aspire them make (ever increasing) efforts (Juelskjær and Staunæs 2014). School architecture has always been an organizer of education, teaching, learning (Foucault, 1995) and with the contemporary conditioned focus...... to current educational agendas of enhancing learning and producing 'successful citizens'....

  13. Deconstruction as concept of architectural practice

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    Maksimović Milan

    2013-01-01

    Full Text Available This paper inquires into the relationship between philosophical concept of deconstruction and its practical application in the interpretation of the concept of architectural creativity. Deconstruction is not only understood as a formal metaphor, but as a critical process that examines common approaches to architectural design and approach to the treatment of architectural space. Through a comparison with philosophy, this procedure highlights the architectural approach seen as a decomposition of normal and usual way of thinking about architecture and therefore associated treatment of the architectural concept in creative practice. By case study method, analyzed the formal concept of building 'Zepter Palace' in Belgrade, which is interpreted as a deconstruction of the concept of architectural practice. In this example, in comparison with the well-known interpretation of deconstruction on project of La Villette Park in Paris, derived a key contribution of the philosophical deconstruction to the concept of architectural practice - approach that establishes and promotes a method for creating and widening of architectural diversity, seen as a new space sensuality of aesthetic experience of space.

  14. Architecture as an emerging Agent of Change

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    Mason White

    2015-11-01

    Full Text Available The most pressing challenge to architecture today is to be more relevant as an agent of change. There is much work needed in making architecture socially and culturally relevant. The value of architecture needs to be better understood by a wider public. As the big city increasingly becomes the subject of interest for advancing architecture’s relevance, the mid-tier cities, countryside and even remote locales are overlooked. Today the term “Design” is often confused with Style. Understanding design as style skips the methods and processes of conceptualization while architecture offers a more complex understanding of design that expands beyond author’s will. For the discipline to be alive and evolve, it is necessary that there be agitation and scepticism cultivated in school.

  15. Software architecture as a set of architectural design decisions

    NARCIS (Netherlands)

    Jansen, Anton; Bosch, Jan; Nord, R; Medvidovic, N; Krikhaar, R; Khrhaar, R; Stafford, J; Bosch, J

    2006-01-01

    Software architectures have high costs for change, are complex, and erode during evolution. We believe these problems are partially due to knowledge vaporization. Currently, almost all the knowledge and information about the design decisions the architecture is based on are implicitly embedded in th

  16. CAAD as Computer-Activated Architectural Design

    DEFF Research Database (Denmark)

    Galle, Per

    1998-01-01

    In a brief sketch, drawing on a general philosophical conception of human interaction with the world, the architectural design process is analysed in terms of two kinds of human action: interpretation and production. Both of these are seen as establishing a link between mental and material entiti...

  17. Sustainable Architecture in the Context of Education: Reponses of Primary School Teachers on the Topical Subject

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    Cencič Majda

    2013-09-01

    Full Text Available The concept of sustainability and a sustainable and ecological development are common debate topics in today’s society. This paper discusses the concept of sustainability in green building with regard to schools. The research was conducted on a representative sample of primary school teachers, focusing on some of their opinions on green building. We asked them which aspect of building they favoured and how often they asked themselves certain questions about the school they taught in. Furthermore, we were interested to see whether we would find age-related differences. To this end, teachers were divided into two groups, namely, teachers of up to 35 years of age and teachers over 35. We were surprised to find that teachers over 35 had a more positive attitude towards green building in schools compared to their younger colleagues. Based on the results, we came to a conclusion that the topics pertaining to ecology and sustainable development are neglected in today’s education. However, making them part of school curriculum is not enough, as the opinions and attitudes of teachers on sustainable and ecological issues also have an important impact on the subject-matter itself.

  18. Pentyl Gallate Nanoemulsions as Potential Topical Treatment of Herpes Labialis.

    Science.gov (United States)

    Kelmann, Regina G; Colombo, Mariana; De Araújo Lopes, Sávia Caldeira; Nunes, Ricardo J; Pistore, Morgana; Dall Agnol, Daniele; Rigotto, Caroline; Silva, Izabella Thais; Roman, Silvane S; Teixeira, Helder F; Oliveira Simões, Cláudia M; Koester, Letícia S

    2016-07-01

    Previous studies have demonstrated the antiherpes activity of pentyl gallate (PG), suggesting that it could be a promising candidate for the topical treatment of human herpes labialis. PG low aqueous solubility represents a major drawback to its incorporation in topical dosage forms. Hence, the feasibility of incorporating PG into nanoemulsions, the ability to penetrate the skin, to inhibit herpes simplex virus (HSV)-1 replication, and to cause dermal sensitization or toxicity were evaluated. Oil/water nanoemulsions containing 0.5% PG were prepared by spontaneous emulsification. The in vitro PG distribution into porcine ear skin after topical application of nanoemulsions was assessed, and the in vitro antiviral activity against HSV-1 replication was evaluated. Acute dermal toxicity and risk of dermal sensitization were evaluated in rat model. Nanoemulsions presented nanometric particle size (from 124.8 to 143.7 nm), high zeta potential (from -50.1 to -66.1 mV), loading efficiency above 99%, and adequate stability during 12 months. All formulations presented anti-HSV-1 activity. PG was able to reach deeper into the dermis more efficiently from the nanoemulsion F4. This formulation as well as PG were considered safe for topical use. Nanoemulsions seem to be a safe and effective approach for topically delivering PG in the treatment of human herpes labialis infection.

  19. ETL as a Necessity for Business Architectures

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    Aurelian TITIRISCA

    2013-07-01

    Full Text Available Today, the new trend that companies are following is to digitalize all data they have in order to reduce costs with physical space and better handle data volume. The new era, the era of bundling data sources and huge volumes of data continues this decade also. In all industries, companies are starting to understand and appreciate the value of data, the value that these volumes of data can produce. Companies are collecting huge volumes of data but not always the actual solution for business intelligence (BI can handle these volumes. To obtain information, those volumes of data are analyzed with extract-transform-load (ETL software solutions. Companies, in the current economic context, are finding hard to invest in improvements of BI process including in ETL process. In this paper I will demonstrate why this kind of investment is necessary and also I will demonstrate that ETL process must be included in BI and big data architectures. In the following pages I will refer to business architectures as BI and big data architectures.

  20. Topical dexketoprofen as a cause of photocontact dermatitis.

    Science.gov (United States)

    López-Abad, R; Paniagua, Ma J; Botey, E; Gaig, P; Rodriguez, P; Richart, C

    2004-01-01

    We reported on the case of a patient who developed a cutaneous eruption in a photoexposed area 1 week after a continous topical treatment with dexketoprofen (Enangel). Photopatch tests were positive for dexketoprofen, ketoprofen and piketoprofen and patch test was positive for piketoprofen. Control photopatch testing with dexketoprofen in 15 healthy volunteers was negative. Dexketoprofen, ketoprofen and piketoprofen are non-steroidal anti-inflamatory drugs (arylpropionic acid derivatives) often used as topical anti-inflammatory agents. It appears that the benzophenone moiety of their chemical structure is the cause of their photosensitivity and cross-photoreaction.

  1. Topical tranexamic acid as a promising treatment for melasma

    Science.gov (United States)

    Ebrahimi, Bahareh; Naeini, Farahnaz Fatemi

    2014-01-01

    Background: In recent times, tranexamic acid (TA) is claimed to have whitening effects especially for ultraviolet-induced hyperpigmentation including melasma. The aim of our study was to evaluate the efficacy and safety of topical solution of TA and compare it with combined solution of hydroquinone and dexamethasone as the gold standard treatment of melasma in Iranian women. Materials and Methods: This was a double-blind split-face trial of 12 weeks which was conducted in Isfahan, Iran. Fifty Iranian melasma patients applied topical solution of 3% TA on one side of the face, and topical solution of 3% hydroquinone + 0.01% dexamethasone on the other side two times a day. The Melasma Area and Severity Index (MASI) and the side effects were evaluated at baseline and every 4 weeks before and after photographs to be compared by a dermatologist were taken. The patient satisfaction was documented at week 12. Results: A repeated measurement analysis was used to evaluate the changes in the MASI score before and after treatments. A significant decreasing trend was observed in the MASI score of both groups with no significant difference between them during the study (P < 0.05). No differences were seen in patients’ and investigator's satisfaction of melasma improvement between two groups (P < 0.05). However, the side effects of hydroquinone + dexamethasone were significantly prominent compared with TA (P = 0.01). Conclusion: This study's results introduce the topical TA as an effective and safe medication for the treatment of melasma. PMID:25422661

  2. Topical tranexamic acid as a promising treatment for melasma

    Directory of Open Access Journals (Sweden)

    Bahareh Ebrahimi

    2014-01-01

    Full Text Available Background: In recent times, tranexamic acid (TA is claimed to have whitening effects especially for ultraviolet-induced hyperpigmentation including melasma. The aim of our study was to evaluate the efficacy and safety of topical solution of TA and compare it with combined solution of hydroquinone and dexamethasone as the gold standard treatment of melasma in Iranian women. Materials and Methods: This was a double-blind split-face trial of 12 weeks which was conducted in Isfahan, Iran. Fifty Iranian melasma patients applied topical solution of 3% TA on one side of the face, and topical solution of 3% hydroquinone + 0.01% dexamethasone on the other side two times a day. The Melasma Area and Severity Index (MASI and the side effects were evaluated at baseline and every 4 weeks before and after photographs to be compared by a dermatologist were taken. The patient satisfaction was documented at week 12. Results: A repeated measurement analysis was used to evaluate the changes in the MASI score before and after treatments. A significant decreasing trend was observed in the MASI score of both groups with no significant difference between them during the study (P < 0.05. No differences were seen in patients′ and investigator′s satisfaction of melasma improvement between two groups (P < 0.05. However, the side effects of hydroquinone + dexamethasone were significantly prominent compared with TA (P = 0.01. Conclusion: This study′s results introduce the topical TA as an effective and safe medication for the treatment of melasma.

  3. Solar thermal energy as a topic in secondary mathematics classrooms

    Energy Technology Data Exchange (ETDEWEB)

    Brinkmann, A.; Brinkmann, K. [EnviPro Environmental Process Engineering Prof. Dr. Klaus Brinkmann, Iserlohn (Germany)

    2004-07-01

    One of the most effective methods to achieve a sustainable change of our momentary existing power supply system to a system mainly based on renewable energy conversion is the education of our children. For this purpose the compulsory school subject mathematics appears to be suitable. In order to promote renewable energy issues in mathematics classrooms, the authors have developed a special didactical concept to open this field for students, as well as for their teachers. The aim of this paper is to present firstly an overview of our concept and secondly examples of problems to the special topic of solar thermal energy, developed on the basis of our concept. (orig.)

  4. Topical fluoride as a cause of dental fluorosis in children

    OpenAIRE

    Wong, MCM; Lo, ECM; Glenny, AM; Tsang, BWK; Worthington, HV; Marinho, VCC

    2009-01-01

    BACKGROUND: For many years, topical use of fluorides has gained greater popularity than systemic use of fluorides. A possible adverse effect associated with the use of topical fluoride is the development of dental fluorosis due to the ingestion of excessive fluoride by young children with developing teeth. OBJECTIVES: To describe the relationship between the use of topical fluorides in young children and the risk of developing dental fluorosis. SEARCH STRATEGY: Electronic search of the Cochra...

  5. Towards reference architectures as an enabler for software ecosystems

    DEFF Research Database (Denmark)

    Knodel, Jens; Manikas, Konstantinos

    2016-01-01

    Software ecosystems - a topic with increasingly growing interest in academia and industry in the past decade - arguably revolutionized many aspects of industrial software engineering (business models, architectures, platforms, project executions, collaboration models, distribution of assets...... health. In this work, we identify a set of challenges and propose a research agenda for the further development of the field towards efficiently improving the existing means of ecosystem orchestration....

  6. [Environmental history as an anthropologic topic. Contribution to "chemical anthropology"].

    Science.gov (United States)

    Grupe, G

    1990-06-01

    Human population history is firmly connected with temporal and regional changes of the environment. Whether natural or anthropogene, alteration of environmental features lead to changes of human life-style and to the development of adaptive strategies. The demand of resources for his subsistence has led man to diverse impacts on his environment since ever. Thus, environmental history is a scientific topic for anthropologists. The research potential of trace element studies of excavated human skeletons for the reconstruction of natural and socio-cultural environments as well as for distribution patterns of hazardous substances is outlined for the European Middle Ages. The scientific value of unravelling past man/environment-interrelationships for both the historical and applied sciences and the place of any "chemical anthropology" within this context is discussed.

  7. TOPICAL IMMUNIZATION AND THE USE OF CHITOSAN AS CARRIER

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    Vengadesh prabhu K

    2011-02-01

    Full Text Available With the technological advances in biomedical sciences and the better understanding of how the immune system works, new immunisation strategies and vaccine delivery options, such sprays, patches, and edible formulations have been developed. Needle-free delivery of vaccines has become a global priority. Transcutaneous immunisation (TCI, topical application of vaccine antigens to the skin, can elicit systemic antibody and T-cell responses, suggesting that this new technique may provide a means for vaccination without needles. TCI requires the use of an adjuvant such as cholera toxin added to a vaccine antigen, such as diphtheria toxoid, to induce antibodies to diphtheria toxoid. The adjuvant and antigen are thought to target Langerhans cells, potent antigen-presenting cells found in the superficial layers of the skin. TCI appears to be a highly practical technique for delivery of vaccines that provides unique access to the immune system.

  8. Elastic vesicles as topical/transdermal drug delivery systems.

    Science.gov (United States)

    Choi, M J; Maibach, H I

    2005-08-01

    Skin acts a major target as well as a principle barrier for topical/transdermal drug delivery. Despite the many advantages of this system, the major obstacle is the low diffusion rate of drugs across the stratum corneum. Several methods have been assessed to increase the permeation rate of drugs temporarily. One simple and convenient approach is application of drugs in formulation with elastic vesicles or skin enhancers. Elastic vesicles are classified with phospholipid (Transfersomes((R)) and ethosomes) and detergent-based types. Elastic vesicles were more efficient at delivering a low and high molecular weight drug to the skin in terms of quantity and depth. Their effectiveness strongly depends on their physicochemical properties: composition, duration and application volume, and entrapment efficiency and application methods. This review focuses on the effect of elastic liposomes for enhancing the drug penetration and defines the action mechanism of penetration into deeper skin.

  9. From green architecture to architectural green

    DEFF Research Database (Denmark)

    Earon, Ofri

    2011-01-01

    they have overshadowed the architectural potential of green architecture. The paper questions how a green space should perform, look like and function. Two examples are chosen to demonstrate thorough integrations between green and space. The examples are public buildings categorized as pavilions. One....... Architectural green could signify green architecture with inclusive interrelations between green and space, built and unbuilt, inside and outside. The aim of the term is to reflect a new focus in green architecture – its architectural performance. Ecological issues are not underestimated or ignored, but so far......The paper investigates the topic of green architecture from an architectural point of view and not an energy point of view. The purpose of the paper is to establish a debate about the architectural language and spatial characteristics of green architecture. In this light, green becomes an adjective...

  10. Review of topical beta blockers as treatment for infantile hemangiomas.

    Science.gov (United States)

    Painter, Sally L; Hildebrand, Göran Darius

    2016-01-01

    The treatment of infantile hemangiomas changed from the use of oral corticosteroids to oral propranolol on the serendipitous discovery of propanolol's clinical effectiveness in 2008. Since then, clinicians have begun to use topical beta blockers--in particular, timolol maleate 0.5% gel forming solution--with good effect. Topical beta blockers are now used for lesions with both deep and superficial components and those that are amblyogenic. When initiated in the proliferative phase of the lesion, the effectiveness of the treatment can be seen within days. There is no consensus on dosing, treatment bioavailability, or clinical assessment of lesions, but these are topics for future research.

  11. Defining Generic Architecture for Cloud Infrastructure as a Service model

    NARCIS (Netherlands)

    Demchenko, Y.; de Laat, C.

    2011-01-01

    Infrastructure as a Service (IaaS) is one of the provisioning models for Clouds as defined in the NIST Clouds definition. Although widely used, current IaaS implementations and solutions doesn’t have common and well defined architecture model. The paper attempts to define a generic architecture for

  12. Traditional buildings of Iran as a sign of sustainable architecture

    Energy Technology Data Exchange (ETDEWEB)

    Rezaei, Davood; Zare, Mohamad [Faculty of engineering, Zanjan University (Iran, Islamic Republic of)], Email: d_rezaei@znu.ac.ir, email: zaremd@yahoo.com

    2011-07-01

    With the rising price of energy and increasing concerns over the environment, ways of creating sustainable architecture are getting more and more attention. Buildings in Iran are confronted with a variety of weather conditions and specific measures have been taken to adapt traditional architecture to the environment and minimize energy consumption. The aim of this paper is to present the different materials and solutions used in traditional Iranian architecture. This review showed that sustainable architecture in an arid climate can be realised by the use of soil as a building insulator. Other methods consist in orienting the building in such a way as to absorb sunlight, using wind towers and wind scope, dividing a yard in such a way that different areas are used, depending on the season, and building underground spaces to provide comfortable conditions. This paper highlighted several historical methods and materials which can be used to bring about sustainable architecture in an arid climate.

  13. On the Psychological Plausibility of "Topic" as a Construct in Research on Writing.

    Science.gov (United States)

    Nunan, David

    1994-01-01

    A study investigated the importance of sentence topic in written discourse. Training second language writers to identify sentence topics in drafts of their written work has been proposed as a central means of helping writers achieve greater coherence. The study explored the notion that "topic" is a psychological rather than linguistic concept, and…

  14. Complementary Therapies for Idiopathic Hirsutism: Topical Licorice as Promising Option

    Directory of Open Access Journals (Sweden)

    Gita Faghihi

    2015-01-01

    Full Text Available Hirsutism is one of the most prevalent health problems in women. The aim of the study was to compare the effect of 755 nm alexandrite hair removal laser with that of alexandrite laser plus topical licorice on the improvement of idiopathic hirsutism. A double-blind, randomized placebo-controlled study was performed on 90 female subjects. The patients were divided into two groups: alexandrite laser plus 15% licorice gel (group A and placebo (group B. Each subject received one of both products over one side of the face, twice daily for 24 weeks on the hirsute locations. Each group underwent five sessions of alexandrite laser at 6-week intervals. To minimize the effects of confounding variables, the test was performed on two separate zones of patients’ skin. The mean ± SD numbers of terminal hairs in group A were 7.05 ± 4.55 for zone 1 and 6.06 ± 3.70 for zone 2. In group B, they were 3.18 ± 1.75 for zone 1 and 2.49 ± 1.63 for zone 2. The difference in the mean number of terminal hairs was statistically significant between the two groups (p<0.001, and there were no serious adverse reactions. The treatment of idiopathic hirsutism with 755 nm alexandrite laser plus topical licorice is more effective than alexandrite laser only.

  15. Architectural Heritage Education: A Summary Report. Local Architecture as a Teaching Resource for High School Courses.

    Science.gov (United States)

    Hatch, Kathlyn; Engels, Nancy

    This report describes a 3-year project which used local architecture as a resource for teaching the arts and humanities at the secondary level. The project involved 24 Massachusetts high school teachers in art, social studies, industrial arts, and the language arts working with project staff. The teachers attended two week-long summer courses.…

  16. Minimalism in architecture: Materials as an instrument of perception

    Directory of Open Access Journals (Sweden)

    Vasilski Dragana

    2013-01-01

    Full Text Available Materials, as an instrument for author's report of his ideas and puts them into the space and time, is a recurring theme of architecture, from the time of Vitruvius triad (firmitas. In minimalism, materials shape space and express its essence, which is the irreducible minimum. The approach in this paper is methodologically defined by architecture domain that is art within it, therefore what the visual means are materials, with the aspiration to discover meaning in what we see. The principles of visual perception are primarily active in the field of law perceptions reached by the psychology of perception, specifically the theory called Gestalt. As the material contained in the tangible components, and sentient, such a relationship is required for duality of materialization, which is achieved by the use of their material expression of immateriality. This expression gives the truth of immateriality (natural materials, tactile value (structure and texture and the 'movement' of the material (the ability to transform. Author's access to the material as an instrument of expression immaterial, provided the concept of minimalist architecture at a higher artistic level (Peter Cumtor and causing severe emotional reaction when meeting also created architectural works (Tadao Ando. Transformations of materials are achieved through the exploration of new treatments and techniques (Kengo Kuma, and the development of technology to unimaginable limits changes the way of understanding reality (Herzog & de Meron. Researching of materials, in the way of its application, can be achieved understanding of minimalism in the architecture as an idea.

  17. Knit as bespoke material practice for architecture

    DEFF Research Database (Denmark)

    Ramsgaard Thomsen, Mette; Tamke, Martin; Karmon, Ayelet;

    2016-01-01

    This paper presents an inquiry into how to inform material systems that allow for a high degree of variation and gradation of their material composition. Presenting knit as a particular system of material fabrication, we discuss how new practices that integrate material design into the architectu...

  18. Architectural Renovations of Body-As-Temple.

    Science.gov (United States)

    Carroll, Timothy

    2016-07-01

    This paper addresses the Christian religious tradition of understanding the human body as the 'temple of the Holy Spirit' within the context of body modification in Eastern Orthodox Christianity. Drawing on ethnographic research in Jerusalem and Kansas City, interviews with artists and Orthodox Christians, and theological discourses on the body and art, this paper seeks to understand how the body is treated by Orthodox Christians and evaluates the ethical commitments and contestations around the human body and religious practice. The paper focuses specifically on tattooing practices, which, though typically prohibited in conservative forms of Christianity, are nonetheless practiced as a means of devotion in specific Eastern Orthodox Christian settings. These modifications to the body are taken in dialogue with ritual and practical concerns exhibited in Eastern Orthodox burial practice. The paper argues that while there are commonalities across Eastern Orthodox practice, the ethical implications of specific actions are highly contextualized and must be interpreted within local regimes of aesthetic behaviour.

  19. Vibrant architecture material realm as a codesigner of living spaces

    CERN Document Server

    Armstrong, Rachel

    2015-01-01

    This book sets out the conditions in which the need for a new approach to the production of architecture in the twenty-first century is established, where our homes and cities are facing increasing pressures from environmental challenges that are compromising our well being and our lives. Vibrant architecture embodies a new kind of architectural design practice that explores how lively materials, or ‘vibrant matter’ may be incorporated into our buildings to confer on them some of the properties of living things such as, movement, growth, sensitivity and self-repair. My research examines the theoretical and practical implications of how this may occur through the application of a new group of materials in the production of our living spaces, collectively referred to as ‘vibrant matter’.

  20. Staged Event-Driven Architecture As A Micro-Architecture Of Distributed And Pluginable Crawling Platform

    Directory of Open Access Journals (Sweden)

    Leszek Siwik

    2013-01-01

    Full Text Available There are many crawling systems available on the market but they are rather close systems dedicated for performing particular kind and class of tasks with predefined set of scope, strategy etc. In real life however there are meaningful groups of users (e.g. marketing, criminal or governmental analysts requiring not just a yet another crawling system dedicated for performing predefined tasks. They need rather easy-to-use, user friendly all-in-one studio for not only executing and running internet robots and crawlers, but also for (graphical (redefining and (recomposing crawlers according to dynamically changing requirements and use-cases. To realize the above-mentioned idea, Cassiopeia framework has been designed and developed. One has to remember, however, that enormous size and unimaginable structural complexity of WWW network are the reasons that, from a technical and architectural point of view, developing effective internet robots – and the more so developing a framework supporting graphical robots’ composition – becomes a really challenging task. The crucial aspect in the context of crawling efficiency and scalability is concurrency model applied. There are two the most typical concurrency management models i.e. classical concurrency based on the pool of threads and processes and event-driven concurrency. None of them are ideal approaches. That is why, research on alternative models is still conducted to propose efficient and convenient architecture for concurrent and distributed applications. One of promising models is staged event-driven architecture mixing to some extent both of above mentioned classical approaches and providing some additional benefits such as splitting application into separate stages connected by events queues – what is interesting taking requirements about crawler (recomposition into account. The goal of this paper is to present the idea and the PoC  implementation of Cassiopeia framework, with the special

  1. An update: choice architecture as a means to change eating behaviour in self-service settings

    DEFF Research Database (Denmark)

    Skov, Laurits Rohden; Perez-Cueto, Armando

    2014-01-01

    Objective: The primary objective of this review was to update the current evidence-base for the use of choice architecture as a means to change eating behaviour in self-service eating settings, hence potentially reducing energy intake. Methodology: 12 databases were searched systematically...... food choices. The majority of studies were of very weak quality and future research should emphasize a real-life setting and compare their results with the effect of other more well-established interventions on food behaviour in self-service eating settings. Key findings: An increasing interest...... in the topic of choice architecture and nudging has increased the scientific output since the last review. There is a clear limitation in the lack of a clear definitions and theoretical foundation....

  2. Expressionism as the radical creative tendency in architecture

    Directory of Open Access Journals (Sweden)

    Alfirević Đorđe

    2012-01-01

    Full Text Available The concepts of expression, expressiveness and expressionism present the key terms on which contemporary architectural and artistic works are based. Although these are essential esthetic categories, the explanations of these concepts are not clearly defined in scientific and theoretical texts. When the term expressionism is mentioned, it often implies the stylistic direction in architecture and the arts, which was created and lasted until the beginning of the XX century in northern Europe (especially in Germany and the Netherlands, and in which the artists have twisted the reality with exaggerated and energetic strokes to express their inner visions, ideas or emotions. However, contemporary theoretical discussions in the arts and architecture point to the manifestation of expressionism in other periods and contexts as well. The basic aim of the text is a critical discourse of interrelations among esthetic categories of expression, expressiveness and expressionism; reexamination of their positions and roles in the system of visual expression, as well as the examination of the starting hypothesis in research, according to which expressionism in architecture is a radical creative tendency with distinctive choleric-sanguine characteristics.

  3. Bupivacaine Lozenge Compared with Lidocaine Spray as Topical Pharyngeal Anesthetic before Unsedated Upper Gastrointestinal Endoscopy

    DEFF Research Database (Denmark)

    Salale, Nesrin; Treldal, Charlotte; Mogensen, Stine;

    2014-01-01

    Unsedated upper gastrointestinal endoscopy (UGE) can induce patient discomfort, mainly due to a strong gag reflex. The aim was to assess the effect of a bupivacaine lozenge as topical pharyngeal anesthetic compared with standard treatment with a lidocaine spray before UGE. Ninety-nine adult...... with a lidocaine spray proved to be a superior option as topical pharyngeal anesthetic before an UGE....

  4. Topics in effective field theory as applied to lattice QCD

    Science.gov (United States)

    Smigielski, Brian

    This thesis focuses on understanding aspects of hadronic physics using numerical and analytic computations which comprise the research fields of Lattice QCD and Effective Field Theories. Lattice QCD is a numerical approximation to QCD that is computed within a finite spacetime volume, a finite lattice spacing, and unphysically large values of the quark mass used to limit computational run time. Because Lattice QCD calculations are implemented with these constraints, it becomes necessary to understand how these constraints influence the physics if we are to extract physical observables. This requires the use and matching of an effective field theory for mesons and baryons which are the fundamental degrees of freedom of the effective field theory Lagrangian. We consider pion and nucleon interactions in Chapter 3 when computational demands force the use of small, spacetime lattices, and extract the axial charge of the nucleon. In Chapters 4 and 5 we examine systems of up to twelve particles of single species, pions or kaons, and mixed species systems of pions and kaons. From these systems we learn about the scattering lengths and three-body forces of these particles. These multi-particle systems also allow one to understand the behavior of finite density systems on the lattice. Lastly in Chapter 6, we examine parton distributions of the pion for a nonzero change in the pion's momentum. These are known as generalized parton distributions and reveal information regarding the valence quarks within a particular hadron. Before the advent of QCD, however, these particles were also known as partons.

  5. Random curds as mathematical models of fractal rhythm in architecture

    Directory of Open Access Journals (Sweden)

    Ćirović Ivana

    2014-01-01

    Full Text Available The author Carl Bovill has suggested and described a method for generating rhythm in architecture with the help of random curds, as they are the mathematical models of unpredictable and uneven groupings which he recognizes in natural shapes and in natural processes. He specified the rhythm generated in this way as the fractal rhythm. Random curds can be generated by a simple process of curdling, as suggested by B. Mandelbrot. This paper examines the way in which the choice of probability for every stage or level of the curdling process, and the number of stages in the procedure of curdling, affect the characteristics of the obtained fractal object as a potential mathematical model of rhythm in the design process. At the same time, this paper examines the characteristics of rhythm in architecture which determine whether the obtained fractal object will be accepted as an appropriate mathematical model of the observed rhythm.

  6. Solid effervescent formulations as new approach for topical minoxidil delivery.

    Science.gov (United States)

    Pereira, Maíra N; Schulte, Heidi L; Duarte, Natane; Lima, Eliana M; Sá-Barreto, Livia L; Gratieri, Tais; Gelfuso, Guilherme M; Cunha-Filho, Marcilio S S

    2017-01-01

    Currently marketed minoxidil formulations present inconveniences that range from a grease hard aspect they leave on the hair to more serious adverse reactions as scalp dryness and irritation. In this paper we propose a novel approach for minoxidil sulphate (MXS) delivery based on a solid effervescent formulation. The aim was to investigate whether the particle mechanical movement triggered by effervescence would lead to higher follicle accumulation. Preformulation studies using thermal, spectroscopic and morphological analysis demonstrated the compatibility between effervescent salts and the drug. The effervescent formulation demonstrated a 2.7-fold increase on MXS accumulation into hair follicles casts compared to the MXS solution (22.0±9.7μg/cm(2) versus 8.3±4.0μg/cm(2)) and a significant drug increase (around 4-fold) in remaining skin (97.1±29.2μg/cm(2)) compared to the drug solution (23.5±6.1μg/cm(2)). The effervescent formulations demonstrated a prominent increase of drug permeation highly dependent on the effervescent mixture concentration in the formulation, confirming the hypothesis of effervescent reaction favoring drug penetration. Clinically, therapy effectiveness could be improved, increasing the administration interval, hence, patient compliance. More studies to investigate the follicular targeting potential and safety of new formulations are needed.

  7. ADAPTIVE REUSE FOR NEW SOCIAL AND MUNICIPAL FUNCTIONS AS AN ACCEPTABLE APPROACH FOR CONSERVATION OF INDUSTRIAL HERITAGE ARCHITECTURE IN THE CZECH REPUBLIC

    Directory of Open Access Journals (Sweden)

    Oleg Fetisov

    2016-04-01

    Full Text Available The present paper deals with a problem of conservation and adaptive reuse of industrial heritage architecture. The relevance and topicality of the problem of adaptive reuse of industrial heritage architecture for new social and municipal functions as the conservation concept are defined. New insights on the typology of industrial architecture are reviewed (e. g. global changes in all European industry, new concepts and technologies in manufacturing, new features of industrial architecture and their construction and typology, first results of industrialization and changes in the typology of industrial architecture in post-industrial period. General goals and tasks of conservation in context of adaptive reuse of industrial heritage architecture are defined (e. g. historical, architectural and artistic, technical. Adaptive reuse as an acceptable approach for conservation and new use is proposed and reviewed. Moreover, the logical model of adaptive reuse of industrial heritage architecture as an acceptable approach for new use has been developed. Consequently, three general methods for the conservation of industrial heritage architecture by the adaptive reuse approach are developed: historical, architectural and artistic, technical. Relevant functional methods' concepts (social concepts are defined and classified. General beneficial effect of the adaptive reuse approach is given. On the basis of analysis results of experience in adaptive reuse of industrial architecture with new social functions general conclusions are developed.

  8. Urban Mining as a Driver for Teaching Architectural Design

    DEFF Research Database (Denmark)

    Vestergaard, Inge; Martin, Guillermo

    2016-01-01

    To teach sustainable architecture is an ongoing process of establishing a frame where the student’s creativity can be challenged by dealing with actual demands on the anthropogenic scene. To use Urban Mining as a driver has been one of the most challenging teaching approaches since many years...... of available materials, and components and as well as their upgrading versus downscaling. The design process explored ways of interconnecting the mined resources and to establish businesses based on this interconnections, producing economic value and social identity for the locals. Working on a site...... characterized by abandoned buildings was a challenge. Both human and environmental aspects were implemented in the project to meet the necessity of future responsible architecture. The discussion sums up the experiences done during a semester course at the graduate level and speculates how the material streams...

  9. Urban Mining as a Driver for Teaching Architectural Design

    DEFF Research Database (Denmark)

    Vestergaard, Inge; Martin Jiménez, Guillermo

    2016-01-01

    To teach sustainable architecture is an ongoing process of establishing a frame where the student’s creativity can be challenged by dealing with actual demands on the anthropogenic scene. To use Urban Mining as a driver has been one of the most challenging teaching approaches since many years...... characterized by abandoned buildings was a challenge. Both human and environmental aspects were implemented in the project to meet the necessity of future responsible architecture. The discussion sums up the experiences done during a semester course at the graduate level and speculates how the material streams...... of available materials, and components and as well as their upgrading versus downscaling. The design process explored ways of interconnecting the mined resources and to establish businesses based on this interconnections, producing economic value and social identity for the locals. Working on a site...

  10. Urban Mining as a Driver for Teaching Architectural Design

    DEFF Research Database (Denmark)

    Vestergaard, Inge; Martin, Guillermo

    2016-01-01

    To teach sustainable architecture is an ongoing process of establishing a frame where the student’s creativity can be challenged by dealing with actual demands on the anthropogenic scene. To use Urban Mining as a driver has been one of the most challenging teaching approaches since many years...... of available materials, and components and as well as their upgrading versus downscaling. The design process explored ways of interconnecting the mined resources and to establish businesses based on this interconnections, producing economic value and social identity for the locals. Working on a site...... could be utilized, if a better and easier access is established located at the urban areas. The conclusion argues that there is a need of critical studies and change of the waste industry and hereby give possibilities for new perspectives in architectural design....

  11. Grid Architecture 2

    Energy Technology Data Exchange (ETDEWEB)

    Taft, Jeffrey D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-01-01

    The report describes work done on Grid Architecture under the auspices of the Department of Electricity Office of Electricity Delivery and Reliability in 2015. As described in the first Grid Architecture report, the primary purpose of this work is to provide stakeholder insight about grid issues so as to enable superior decision making on their part. Doing this requires the creation of various work products, including oft-times complex diagrams, analyses, and explanations. This report provides architectural insights into several important grid topics and also describes work done to advance the science of Grid Architecture as well.

  12. The role of topical antibiotics used as prophylaxis in surgical site infection prevention.

    LENUS (Irish Health Repository)

    McHugh, S M

    2011-04-01

    Compared with systemic antibiotic therapy, the topical or local delivery of an antibiotic has many potential advantages. However, local antibiotics at the surgical site have received very limited approval in any of the surgical prophylaxis consensus guidelines that we are aware of. A review of the literature was carried out through searches of peer-reviewed publications in PubMed in the English language over a 30 year period between January 1980 and May 2010. Both retrospective and prospective studies were included, as well as meta-analyses. With regard to defining \\'topical\\' or \\'local\\' antibiotic application, the application of an antibiotic solution to the surgical site intraoperatively or immediately post-operatively was included. A number of surgical procedures have been shown to significantly benefit from perioperative topical prophylaxis, e.g. joint arthroplasty, cataract surgery and, possibly, breast augmentation. In obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. The selective use of topical antibiotics as surgical prophylaxis is justified for specific procedures, such as joint arthroplasty, cataract surgery and, possibly, breast augmentation. In selective cases, such as obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. Apart from these specific indications, the evidence for use of topical antibiotics in surgery is lacking in conclusive randomized controlled trials.

  13. The role of topical antibiotics used as prophylaxis in surgical site infection prevention.

    LENUS (Irish Health Repository)

    McHugh, S M

    2012-02-01

    Compared with systemic antibiotic therapy, the topical or local delivery of an antibiotic has many potential advantages. However, local antibiotics at the surgical site have received very limited approval in any of the surgical prophylaxis consensus guidelines that we are aware of. A review of the literature was carried out through searches of peer-reviewed publications in PubMed in the English language over a 30 year period between January 1980 and May 2010. Both retrospective and prospective studies were included, as well as meta-analyses. With regard to defining \\'topical\\' or \\'local\\' antibiotic application, the application of an antibiotic solution to the surgical site intraoperatively or immediately post-operatively was included. A number of surgical procedures have been shown to significantly benefit from perioperative topical prophylaxis, e.g. joint arthroplasty, cataract surgery and, possibly, breast augmentation. In obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. The selective use of topical antibiotics as surgical prophylaxis is justified for specific procedures, such as joint arthroplasty, cataract surgery and, possibly, breast augmentation. In selective cases, such as obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. Apart from these specific indications, the evidence for use of topical antibiotics in surgery is lacking in conclusive randomized controlled trials.

  14. Dynamic Neural Fields as a Step Towards Cognitive Neuromorphic Architectures

    Directory of Open Access Journals (Sweden)

    Yulia eSandamirskaya

    2014-01-01

    Full Text Available Dynamic Field Theory (DFT is an established framework for modelling embodied cognition. In DFT, elementary cognitive functions such as memory formation, formation of grounded representations, attentional processes, decision making, adaptation, and learning emerge from neuronal dynamics. The basic computational element of this framework is a Dynamic Neural Field (DNF. Under constraints on the time-scale of the dynamics, the DNF is computationally equivalent to a soft winner-take-all (WTA network, which is considered one of the basic computational units in neuronal processing. Recently, it has been shown how a WTA network may be implemented in neuromorphic hardware, such as analogue Very Large Scale Integration (VLSI device. This paper leverages the relationship between DFT and soft WTA networks to systematically revise and integrate established DFT mechanisms that have previously been spread among different architectures. In addition, I also identify some novel computational and architectural mechanisms of DFT which may be implemented in neuromorphic VLSI devices using WTA networks as an intermediate computational layer. These specific mechanisms include the stabilization of working memory, the coupling of sensory systems to motor dynamics, intentionality, and autonomous learning. I further demonstrate how all these elements may be integrated into a unified architecture to generate behavior and autonomous learning.

  15. Building Structure Design as an Integral Part of Architecture: A Teaching Model for Students of Architecture

    Science.gov (United States)

    Unay, Ali Ihsan; Ozmen, Cengiz

    2006-01-01

    This paper explores the place of structural design within undergraduate architectural education. The role and format of lecture-based structure courses within an education system, organized around the architectural design studio is discussed with its most prominent problems and proposed solutions. The fundamental concept of the current teaching…

  16. The start up as a phase of architectural design process.

    Science.gov (United States)

    Castro, Iara Sousa; Lima, Francisco de Paula Antunes; Duarte, Francisco José de Castro Moura

    2012-01-01

    Alterations made in the architectural design can be considered as a continuous process, from its conception to the moment a built environment is already in use. This article focuses on the "moving phase", which is the initial moment of the environment occupation and the start-up of services. It aims to show that the continuity of ergonomics interventions during the "moving phase" or start up may reveal the built environment inadequacies; clearly showing needs not met by the design and allowing making instant decisions to solve non-foreseen problems. The results have revealed some lessons experienced by users during a critical stage not usually included in the design process.

  17. New computer architectures as tools for ecological thought.

    Science.gov (United States)

    Villa, F

    1992-06-01

    Recent achievements of computer science provide unrivaled power for the advancement of ecology. This power is not merely computational: parallel computers, having hierarchical organization as their architectural principle, also provide metaphors for understanding complex systems. In this sense they might play for a science of ecological complexity a role like equilibrium-based metaphors had in the development of dynamic systems ecology. Parallel computers provide this opportunity through an informational view of ecological reality and multilevel modelling paradigms. Spatial and individual-oriented models allow application and full understanding of the new metaphors in the ecological context.

  18. Cutaneous penetration of the topically applied photosensitizer Pc 4 as detected by intravital 2-photon laser scanning microscopy.

    Science.gov (United States)

    Huang, Alex Y; Myers, Jay T; Barkauskas, Deborah; Howell, Scott J; Oleinick, Nancy L; McCormick, Thomas S; Cooper, Kevin D; Baron, Elma D; Lam, Minh

    2012-09-01

    The fundamental mechanism of photodynamic therapy (PDT)-induced cell death has been characterized, but early critical PDT events in vivo remain incompletely defined. With the recent development in advanced fluorescence imaging modalities, such as intravital 2-photon laser scanning microscopy (2P-LSM), researchers are now able to investigate and visualize biological processes with high resolution in real time. This powerful imaging technology allows deep tissue visualization with single-cell resolution, thus providing dynamic information on the 3-dimensional architectural makeup of the tissue. The main goal of this study was to determine the cutaneous penetration of a topically applied photosensitizer, the silicon phthalocyanine Pc 4, into the skin of live animals and to assess the effective absorption of Pc 4 through the skin barrier. Our 2P-LSM images indicate that Pc 4 penetrates to the epidermal/dermal junction of mouse skin. The data also indicate that the degree of Pc 4 absorption is dose dependent. These findings represent initial steps that may help in improving the clinical utilization of topical Pc 4-PDT.

  19. 75 FR 5637 - Culturally Significant Objects Imported for Exhibition Determinations: “Architecture as Icon...

    Science.gov (United States)

    2010-02-03

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Architecture as Icon: Perception and... Icon: Perception and Representation of Architecture in Byzantine Art,'' imported from abroad...

  20. Topical cyclosporin as an alternative treatment for vision threatening blepharokeratoconjunctivitis: a case report

    Directory of Open Access Journals (Sweden)

    Ismail AS

    2012-06-01

    Full Text Available Abdul-Salim Ismail,1,2 Rohana Taharin,2 Zunaina Embong11Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, 2Department of Ophthalmology, Hospital Pulau Pinang, Jalan Resindensi, Pulau Pinang, MalaysiaAbstract: Here, a case of vision threatening blepharokeratoconjunctivitis that responded well to topical cyclosporin is reported. A 9-year-old Malay girl with a history of bilateral blepharokeratoconjunctivitis was regularly treated with lid scrubbing using diluted baby shampoo, fusidic acid gel, and topical steroids as well as an intermittent course of oral doxycycline for the past year. She developed acute onset bilateral eye redness associated with poor vision in her right eye. Both eyes showed marked diffuse hyperemic conjunctiva with corneal vascularization. The presence of corneal vascularization obscured the visual axis in the right eye. The condition did not improve with regular intensive lid hygiene using diluted baby shampoo, fusidic acid gel, and topical steroids. She was started on topical cyclosporin A 0.5% every 6 hours. There was a dramatic regression of corneal vascularization after 3 days on topical cyclosporin, with marked improvement in visual acuity. This is a single case in which cyclosporin improved the status of the ocular surface. A large cohort study is required to justify its effectiveness in treating blepharokeratoconjunctivitis and to test its potential as an alternative immunosuppressive agent in comparison to conventional corticosteroids.Keywords: blepharokeratoconjunctivitis, cyclosporin

  1. Architecture of the Florida Power Grid as a Complex Network

    CERN Document Server

    Xu, Yan; Rikvold, Per Arne

    2013-01-01

    We study the Florida high-voltage power grid as a technological network embedded in space. Measurements of geographical lengths of transmission lines, the mixing of generators and loads, the weighted clustering coefficient, as well as the organization of edge conductance weights show a complex architecture quite different from random-graph models usually considered. In particular, we introduce a parametrized mixing matrix to characterize the mixing pattern of generators and loads in the Florida Grid, which is intermediate between the random mixing case and the semi-bipartite case where generator-generator transmission lines are forbidden. Our observations motivate an investigation of optimization (design) principles leading to the structural organization of power grids. We thus propose two network optimization models for the Florida Grid as a case study. Our results show that the Florida Grid is optimized not only by reducing the construction cost (measured by the total length of power lines), but also throug...

  2. Architectural Intention as the Mediator of Lean Housing Construction

    DEFF Research Database (Denmark)

    Frier, Marie; Kirkegaard, Poul Henning; Fisker, Anna Marie

    2008-01-01

    In recent years a number of companies have taken up the challenge of producing prefab houses using lean principles, hereby incorporating value driven production theory as the means to optimize construction processes. However, the value of home is dependent on architectural qualities and interior...... and prefab production as lean construction strategies hold obvious potentials in the development of an effective building envelope with regards to indoor climate, assembly etc. However, the discussion of lean construction, future working co operations and processes, often avoid an actual positioning...... spatial experiences difficult to operationalize as production objectives. As stated by Sven Bertelsen a home should be more than the sum of the parts; the home constitutes our physical and metaphysical being and there is deep feelings connected to this phenomenon (Bertelsen, 2005). Modularization...

  3. Mosque as a Model of Learning Principles of Sustainable Architecture

    Directory of Open Access Journals (Sweden)

    Swambodo Murdariatmo Adi

    2016-06-01

    Full Text Available The mosque is an integral part of the circuit-worship rituals of Islam. For Muslims in Indonesia, the role of the mosque as a place of worship, examines religion and some other activities occupy a strategic position not only as a religious symbol but more emphasis on the function of the space as a public building. Utilization of space in public buildings as well as space-ritual-social space will have meaning for the people in view of adaptation space used. Awareness of the importance of effective space utilization and management of water resources wisely in support of the ritual apply the principles of sustainable architecture will have a positive impact for the people to give directions as to how the principle of austerity-not wasteful in Islam can be applied. This paper will discuss about the process of continuous learning from the essence of understanding of the mosque as a model in implementing the process of life, taking into account the principles of simplicity, functional and wisdom, especially in the efficiency of utilization of local resources. The method used in this research is qualitative descriptive, which is explained the theory and based on literature and accompanied by case study that have implemented the principles. The output of this application of the principles of sustainable architecture in the planning and use of mosques as a place in the relationship with God and with fellow human relations can be a model for the faithful to deal with wisely challenge natural resource constraints, especially for future generations.

  4. Interior Design in Architectural Education

    Science.gov (United States)

    Gurel, Meltem O.; Potthoff, Joy K.

    2006-01-01

    The domain of interiors constitutes a point of tension between practicing architects and interior designers. Design of interior spaces is a significant part of architectural profession. Yet, to what extent does architectural education keep pace with changing demands in rendering topics that are identified as pertinent to the design of interiors?…

  5. Hierarchical Surface Architecture of Plants as an Inspiration for Biomimetic Fog Collectors.

    Science.gov (United States)

    Azad, M A K; Barthlott, W; Koch, K

    2015-12-01

    Fog collectors can enable us to alleviate the water crisis in certain arid regions of the world. A continuous fog-collection cycle consisting of a persistent capture of fog droplets and their fast transport to the target is a prerequisite for developing an efficient fog collector. In regard to this topic, a biological superior design has been found in the hierarchical surface architecture of barley (Hordeum vulgare) awns. We demonstrate here the highly wettable (advancing contact angle 16° ± 2.7 and receding contact angle 9° ± 2.6) barbed (barb = conical structure) awn as a model to develop optimized fog collectors with a high fog-capturing capability, an effective water transport, and above all an efficient fog collection. We compare the fog-collection efficiency of the model sample with other plant samples naturally grown in foggy habitats that are supposed to be very efficient fog collectors. The model sample, consisting of dry hydrophilized awns (DH awns), is found to be about twice as efficient (fog-collection rate 563.7 ± 23.2 μg/cm(2) over 10 min) as any other samples investigated under controlled experimental conditions. Finally, a design based on the hierarchical surface architecture of the model sample is proposed for the development of optimized biomimetic fog collectors.

  6. Arhitektuur avaliku arutluse teemana = Architecture as a Topic for Public Discussion / Maarja Lõhmus

    Index Scriptorium Estoniae

    Lõhmus, Maarja, 1960-

    2007-01-01

    Tartu Ülikooli ajakirjanduse ja kommunikatsiooni osakonna meediauuringute dotsent Maarja Lõhmus püüab kaardistada kujunenud meediavälja ja esitada neid indikaatoreid, millest praegu sõltub arhitektuuri käsitlemine avalikkuses

  7. DESIGN AS GENERATOR (DAG: AN ARCHITECTURAL APPROACH FOR EMPOWERING COMMUNITY

    Directory of Open Access Journals (Sweden)

    KATOPPO Martin

    2014-12-01

    Full Text Available Design as we imagine should act like a generator, to become light for others. This is the concept of Design as Generator (DAG. It main goal is for bring the essence of Architecture in which to enhance the quality of life not just for self but for others. For this purpose we create D-Apps (Dwelling Applications, D-PaD and A-PaD (Dwelling and Area Prototype Applicative Design that will explained by our experimental dwelling project 200 Rumah Besi and our future project taki (taman kita Community Sustainable Park. We also developed DAG particular empowering and participatory design methodology – inspired by PAR (Participatory Action Research and DT (Design Thinking through mixed methods research, the Sequential Embedded Experimental Model.

  8. Performance based parameters as generators in digital architecture

    DEFF Research Database (Denmark)

    Petersen, Mads Dines; Knudstrup, Mary-Ann

    2009-01-01

    because of the high energy use buildings have. It calls for a rethinking of our approach to architecture and for an implementation architectural and technical demands from the beginning of the design process. The term generating in relation to this article is focused on algorithms and parametric...

  9. Remote Control for Robotic Systems Using CORBA as Communication Architecture

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    This paper proposes a novel method to implement network connections among a client and remoterobotic systems using CORBA for developing telecare system to aid the aged or disabled. The proposed methodmakes system have low cost and wide availability, high scaling and inter-operating ability to allow the clients andserver objects, written in different languages, run in different operating system, and connected in different net-work to inter-operate. It also makes system easy to be extended and integrated with the other technologies andapplications distributed over the Internet. Using CORBA as a communication architecture, we developed hard-ware base, task-level robot arm control server, live image feedback server and mobile robot control server,which can provide some basic care services to aid the aged and disabled.

  10. Lipid nano/submicron emulsions as vehicles for topical flurbiprofen delivery.

    Science.gov (United States)

    Fang, Jia-You; Leu, Yann-Lii; Chang, Chia-Chun; Lin, Chia-Hsuan; Tsai, Yi-Hung

    2004-01-01

    The application of lipid nano/submicron emulsions as topical drug carrier systems for the percutaneous absorption of flurbiprofen was investigated. The lipid emulsions were made up of isopropyl myristate (IPM), soybean oil, or coconut oil as the oil phase, egg lecithin as the predominant emulsifier, and double-distilled water as the external phase. Stearylamine (SA) and deoxycholic acid (DA) also were used to produce positively and negatively charged emulsions. To evaluate the physicochemical properties of the lipid emulsions, particle size by laser light scattering, the image of atomic force microscopy, and relaxation time values by Nuclear Magnetic Resonance (NMR) were determined. The in vitro permeation data showed that incorporation of SA significantly reduced the topical delivery of flurbiprofen. On the other hand, incorporation of DA exhibited no or a negligible effect on drug permeation. Enhancement of drug absorption was observed when adding oleic acid as part of the oil phase. The in vivo topical application of flurbiprofen from selected lipid emulsions showed a similar trend to the in vitro status. Furthermore, the intersubject variability was considerably reduced by lipid emulsions than by aqueous suspensions in both the in vitro and in vivo experiments. The irritant profiles of lipid emulsions showed that IPM elicited higher irritation than soybean oil. The incorporation of oleic acid also produced skin disruption. The results in the present study suggest the feasibility of lipid emulsions for the topical delivery of flurbiprofen.

  11. Architecture of the Florida power grid as a complex network

    Science.gov (United States)

    Xu, Yan; Gurfinkel, Aleks Jacob; Rikvold, Per Arne

    2014-05-01

    We study the Florida high-voltage power grid as a technological network embedded in space. Measurements of geographical lengths of transmission lines, the mixing of generators and loads, the weighted clustering coefficient, as well as the organization of edge conductance weights show a complex architecture quite different from random-graph models usually considered. In particular, we introduce a parametrized mixing matrix to characterize the mixing pattern of generators and loads in the Florida Grid, which is intermediate between the random mixing case and the semi-bipartite case where generator-generator transmission lines are forbidden. Our observations motivate an investigation of optimization (design) principles leading to the structural organization of power grids. We thus propose two network optimization models for the Florida Grid as a case study. Our results show that the Florida Grid is optimized not only by reducing the construction cost (measured by the total length of power lines), but also through reducing the total pairwise edge resistance in the grid, which increases the robustness of power transmission between generators and loads against random line failures. We then embed our models in spatial areas of different aspect ratios and study how this geometric factor affects the network structure, as well as the box-counting fractal dimension of the grids generated by our models.

  12. Architecture on Architecture

    DEFF Research Database (Denmark)

    Olesen, Karen

    2016-01-01

    This paper will discuss the challenges faced by architectural education today. It takes as its starting point the double commitment of any school of architecture: on the one hand the task of preserving the particular knowledge that belongs to the discipline of architecture, and on the other hand...... that is not scientific or academic but is more like a latent body of data that we find embedded in existing works of architecture. This information, it is argued, is not limited by the historical context of the work. It can be thought of as a virtual capacity – a reservoir of spatial configurations that can...... the autonomy of architecture, not as an esoteric concept but as a valid source of information in a pragmatic design practice, may help us overcome the often-proclaimed dichotomy between formal autonomy and a societally committed architecture. It follows that in architectural education there can be a close...

  13. Coherent Architecture Development as a Basis for Technology Development

    DEFF Research Database (Denmark)

    Ravn, Poul Martin

    coherence. Despite the acceptance and results presented in multiple studies from the application of architectures, the research on architecture work in a technology development context is limited. Technologies are often developed and represented in the form of product sub-systems that are made available......The subject of this PhD thesis is architecture-centered design. It elaborates especially on two specific areas: the coherence in architectures in a technology development context and the identification of critical development areas via property-based reasoning, based on an understanding of cette...... for product developers. Technologies, which in their infancy indicate a 'jack of all trades, master of none', have a risk of being developed without a clearly defined need or identification of which products it can be used in. A common approach for developing such a technology includes exploration of what...

  14. Treatment of corneal squamous cell carcinoma using topical 1% 5-fluorouracil as monotherapy.

    Science.gov (United States)

    Dorbandt, Daniel M; Driskell, Elizabeth A; Hamor, Ralph E

    2016-05-01

    The purpose of this report is to discuss the use of topical 1% 5-fluorouracil as a sole therapy for canine corneal squamous cell carcinoma (SCC). A 12-year-old castrated male pug was evaluated for a well-demarcated, central, 3 mm in diameter, pale pink, raised, right corneal mass. An incisional biopsy was obtained using a #64 beaver blade after topical anesthesia and without sedation. A definitive diagnosis of corneal SCC was obtained after histopathologic evaluation of the biopsy. Topical 1% 5-fluorouracil ointment was applied to the right eye four times daily for 2 weeks followed by no treatment for 2 weeks, then treatment again twice daily for 2 weeks. The cornea remained free of recurrence 10 months after cessation of treatment. In dogs affected with corneal SCC, topical 1% 5-fluorouracil monotherapy may be a viable and cost-effective treatment option with minimal side effects. This chemotherapy agent may also have an effect on corneal pigmentation. Chronic cyclosporine therapy did not contribute to the pathogenesis of corneal SCC in the case described.

  15. Tutorial on architectural acoustics

    Science.gov (United States)

    Shaw, Neil; Talaske, Rick; Bistafa, Sylvio

    2002-11-01

    This tutorial is intended to provide an overview of current knowledge and practice in architectural acoustics. Topics covered will include basic concepts and history, acoustics of small rooms (small rooms for speech such as classrooms and meeting rooms, music studios, small critical listening spaces such as home theatres) and the acoustics of large rooms (larger assembly halls, auditoria, and performance halls).

  16. In vitro analysis of polyurethane foam as a topical hemostatic agent.

    Science.gov (United States)

    Broekema, Ferdinand I; van Oeveren, Wim; Zuidema, Johan; Visscher, Susan H; Bos, Rudolf R M

    2011-04-01

    Topical hemostatic agents can be used to treat problematic bleedings in patients who undergo surgery. Widely used are the collagen- and gelatin-based hemostats. This study aimed to develop a fully synthetic, biodegradable hemostatic agent to avoid exposure to animal antigens. In this in vitro study the suitability of different newly developed polyurethane-based foams as a hemostatic agent has been evaluated and compared to commonly used agents. An experimental in vitro test model was used in which human blood flowed through the test material. Different modified polyurethane foams were compared to collagen and gelatin. The best coagulation was achieved with collagen. The results of the polyurethane foam improved significantly by increasing the amount of polyethylene glycol. Therefore, the increase of the PEG concentration seems a promising approach. Additional in vivo studies will have to be implemented to assess the application of polyurethane foam as a topical hemostatic agent.

  17. Comparative study of liposomes, transfersomes and ethosomes as carriers for improving topical delivery of celecoxib.

    Science.gov (United States)

    Bragagni, Marco; Mennini, Natascia; Maestrelli, Francesca; Cirri, Marzia; Mura, Paola

    2012-01-01

    Topical administration of celecoxib proved to be an effective mean of preventing skin cancer development and improving anticancer drugs effectiveness in skin tumors treatment. The aim of this study was the development of an effective topical formulation of celecoxib, able to promote drug skin delivery, providing its in depth penetration through the skin layers. Three kinds of vesicular formulations have been investigated as drug carriers: liposomes containing a surfactant, or transfersomes and ethosomes, containing suitable edge activators. Firstly, the effect of membrane composition variations on the system performance has been evaluated for each vesicle type. Selected formulations were characterized for particle size, polydispersity index and encapsulation efficiency. The best formulations were subjected to ex vivo permeation studies through excised human skin. All vesicular formulations markedly (p ethosomes, respectively. In particular, ethosomes containing Tween 20 as edge activator not only showed the best vesicle dimensions and homogeneity, and the highest encapsulation efficacy (54.4%), but also enabled the highest increase in drug penetration through the skin, probably due to the simultaneous presence in their composition of ethanol and Tween 20, both acting as permeation enhancers. Therefore, among the various vesicular formulations examined in the study, Tween 20-ethosomes can be considered the most promising one as carrier for topical celecoxib applications aimed to prevent skin cancer development and increase the anticancer drugs effectiveness against skin tumors.

  18. Final Technical Report summarizing Purdue research activities as part of the DOE JET Topical Collaboration

    Energy Technology Data Exchange (ETDEWEB)

    Molnar, Denes [Purdue Univ., West Lafayette, IN (United States). Dept. of Physics and Astronomy

    2015-09-01

    This report summarizes research activities at Purdue University done as part of the DOE JET Topical Collaboration. These mainly involve calculation of covariant radiative energy loss in the (Djordjevic-)Gyulassy-Levai-Vitev ((D)GLV) framework for relativistic A+A reactions at RHIC and LHC energies using realistic bulk medium evolution with both transverse and longitudinal expansion. The single PDF file provided also includes a report from the entire JET Collaboration.

  19. [Medical topics of the Goethe period as reflected in the Goethe Dictionary].

    Science.gov (United States)

    Schlaps, Christiane

    2010-01-01

    This paper deals with some medical topics which were mentioned or discussed by Johann Wolfgang von Goethe and can thus be found in the dictionary which lists and explains all the words he used, the Goethe Dictionary. The author makes a case for the use of this primarily literary and linguistic work e. g. as source material for historians of medicine and shows some of its possible uses.

  20. Microemulsions as vehicles for topical administration of voriconazole: formulation and in vitro evaluation.

    Science.gov (United States)

    El-Hadidy, Gladious Naguib; Ibrahim, Howida Kamal; Mohamed, Magdi Ibrahim; El-Milligi, Mohamed Farid

    2012-01-01

    This work was undertaken to investigate microemulsion (ME) as a topical delivery system for the poorly water-soluble voriconazole. Different ME components were selected for the preparation of plain ME systems with suitable rheological properties for topical use. Two permeation enhancers were incorporated, namely sodium deoxycholate or oleic acid. Drug-loaded MEs were evaluated for their physical appearance, pH, rheological properties and in vitro permeation studies using guinea pig skin. MEs based on polyoxyethylene(10)oleyl ether (Brij 97) as the surfactant showed pseudoplastic flow with thixotropic behavior and were loaded with voriconazole. Jojoba oil-based MEs successfully prolonged voriconazole release up to 4 h. No significant changes in physical or rheological properties were recorded on storage for 12 months at ambient conditions. The presence of permeation enhancers favored transdermal rather than dermal delivery. Sodium deoxycholate was more effective than oleic acid for enhancing the voriconazole permeation. Voriconazole-loaded MEs, with and without enhancers, showed significantly better antifungal activity against Candida albicans than voriconazole supersaturated solution. In conclusion, the studied ME formulae could be promising vehicles for topical delivery of voriconazole.

  1. Resina Draconis as a topical treatment for pressure ulcers: A systematic review and meta-analysis.

    Science.gov (United States)

    Xu, Jiaqi; Xiong, Tian; Yang, Ying; Li, Jie; Mao, Jing

    2015-01-01

    In recent years, a number of studies have reported on Resina Draconis (RD) as a topical treatment for pressure ulcers. To evaluate these studies, we performed a systematic review and meta-analysis aimed to examine the efficacy of RD for pressure ulcers. We searched eight electronic databases to identify randomized controlled trials in which RD treatment was compared with other topical treatment of pressure ulcers from 1980 to 2014. Selection of studies, study appraisal, data extraction and analysis were undertaken using standard methods. Fourteen randomized controlled trials were included involving 618 patients. The results of the meta-analysis showed that, RD treatment was significantly associated with a higher healing rate for pressure ulcers (risk ratio 2.07, 95% confidence intervals 1.73-2.48, p < 0.001). The results of descriptive analysis showed that, compared with the control group, RD treatment shortened healing time. As for safety, adverse reactions had not been reported. These results suggest that RD can improve the healing rate for pressure ulcers and shorten the healing time, compared with other topical treatments. However, due to limited quality and quantity of the included studies, this conclusion needs to be proved by more high quality studies.

  2. Book history as a research topic in Croatian journals from 2001 to 2010

    Directory of Open Access Journals (Sweden)

    Jasna Tingle

    2013-02-01

    Full Text Available The aim of the paper is to determine the scope and content of Croatian research output in the field of book history, determine which Croatian journals publish papers on book history, the topics covered and the number of scholars who do research in this field. The research was conducted on the corpus of 177 papers published in 17 Croatian journals from 2001 to 2010. The data collected indicates that few journals regularly publish papers on book history, and only one journal explicitly states book history as its major area of interest. Furthermore, it is evident that very few scholars regularly or occasionally do research on book history. The topics covered in selected papers bear witness to a wide range of interests, but only few papers follow recent trends in world book history research. This paper, however, does not cover scholarly or trade monographs and conference proceedings published during the time under investigation, which is one of the limitations of the current research. Still, the output in scholarly and trade journals, which are the main channels of scholarly communication, provides a relevant sample for determining the incidence of book history as a research topic in Croatian science. These findings are the main research contribution of this paper.

  3. Model & scale as conceptual devices in architectural representation

    NARCIS (Netherlands)

    Stellingwerff, M.C.; Koorstra, P.A.

    2013-01-01

    This year we celebrate the tenth anniversary of our Computer Aided Manufacturing laboratory (CAMlab, http://www.camlab-bk.nl). From the start we provide laser cutting, CNC-milling and 3D-print facilities for the students and the researchers at the Faculty of Architecture in Delft. Over the past ten

  4. India's Vernacular Architecture as a Reflection of Culture.

    Science.gov (United States)

    Masalski, Kathleen Woods

    This paper contains the narrative for a slide presentation on the architecture of India. Through the narration, the geography and climate of the country and the social conditions of the Indian people are discussed. Roofs and windows are adapted for the hot, rainy climate, while the availability of building materials ranges from palm leaves to mud…

  5. The Linux kernel as flexible product-line architecture

    NARCIS (Netherlands)

    Jonge, M. de

    2002-01-01

    The Linux kernel source tree is huge ($>$ 125 MB) and inflexible (because it is difficult to add new kernel components). We propose to make this architecture more flexible by assembling kernel source trees dynamically from individual kernel components. Users then, can select what component they real

  6. TOPICAL REVIEW: Metallo-supramolecular modules as a paradigm for materials science

    Directory of Open Access Journals (Sweden)

    Dirk G Kurth

    2008-01-01

    Full Text Available Metal ion coordination in discrete or extended metallo-supramolecular assemblies offers ample opportunity to fabricate and study devices and materials that are equally important for fundamental research and new technologies. Metal ions embedded in a specific ligand field offer diverse thermodynamic, kinetic, chemical, physical and structural properties that make these systems promising candidates for active components in functional materials. A key challenge is to improve and develop methodologies for placing these active modules in suitable device architectures, such as thin films or mesophases. This review highlights recent developments in extended, polymeric metallo-supramolecular systems and discrete polyoxometalates with an emphasis on materials science.

  7. Treating umbilical granuloma with topical clobetasol propionate cream at home is as effective as treating it with topical silver nitrate in the clinic

    DEFF Research Database (Denmark)

    Brødsgaard, Anne; Nielsen, Tove; Mølgaard, Ulla

    2015-01-01

    AIM: There is a lack of evidence on the best treatment option for umbilical granuloma. The primary aim of this study was to compare three treatments for umbilical granuloma: standard treatment with topical silver nitrate, clobetasol propionate cream (0.05%) and ethanol wipes. The secondary aim......%) in the outpatient clinic, 30 infants had topical clobetasol propionate cream (0.05%) applied at home, and 34 infants received cleansing with ethanol wipes (82%) at home. RESULTS: Silver nitrate and clobetasol propionate cream (0.05%) were significantly superior to ethanol wipes, with shorter healing times...... and higher resolution rates (p = 0.0001). Healing time and resolution rates were identical for silver nitrate and clobetasol propionate cream (0.05%). Mild side effects were occasionally reported, all of which were self-limiting. CONCLUSION: Treating umbilical granuloma with topical clobetasol propionate...

  8. DFT algorithms for bit-serial GaAs array processor architectures

    Science.gov (United States)

    Mcmillan, Gary B.

    1988-01-01

    Systems and Processes Engineering Corporation (SPEC) has developed an innovative array processor architecture for computing Fourier transforms and other commonly used signal processing algorithms. This architecture is designed to extract the highest possible array performance from state-of-the-art GaAs technology. SPEC's architectural design includes a high performance RISC processor implemented in GaAs, along with a Floating Point Coprocessor and a unique Array Communications Coprocessor, also implemented in GaAs technology. Together, these data processors represent the latest in technology, both from an architectural and implementation viewpoint. SPEC has examined numerous algorithms and parallel processing architectures to determine the optimum array processor architecture. SPEC has developed an array processor architecture with integral communications ability to provide maximum node connectivity. The Array Communications Coprocessor embeds communications operations directly in the core of the processor architecture. A Floating Point Coprocessor architecture has been defined that utilizes Bit-Serial arithmetic units, operating at very high frequency, to perform floating point operations. These Bit-Serial devices reduce the device integration level and complexity to a level compatible with state-of-the-art GaAs device technology.

  9. An Introduction to Topic Modeling as an Unsupervised Machine Learning Way to Organize Text Information

    Science.gov (United States)

    Snyder, Robin M.

    2015-01-01

    The field of topic modeling has become increasingly important over the past few years. Topic modeling is an unsupervised machine learning way to organize text (or image or DNA, etc.) information such that related pieces of text can be identified. This paper/session will present/discuss the current state of topic modeling, why it is important, and…

  10. A Reference Architecture for a Cloud-Based Tools as a Service Workspace

    DEFF Research Database (Denmark)

    Chauhan, Aufeef; Babar, Muhammad Ali; Sheng, Quan Z.

    2015-01-01

    Software Architecture (SA) plays a critical role in developing and evolving cloud-based applications. We present a Reference Architecture (RA) for designing Cloud-based Tools as a service work SPACE (TSPACE) - a platform for provisioning chain of tools following the Software as a Service (SaaS) m...

  11. Landscape architecture as an entity of property development in Wilayah Persekutuan, Putrajaya

    Directory of Open Access Journals (Sweden)

    Ahmad Nasyution bin Abdul Razak

    2015-12-01

    Full Text Available This study explores the relationship between landscape architecture and property development. Landscape architecture emphasizes the nature of conservation, development of public parks, city parks, local parks, artificial forests, lakes, recreational areas, outdoor recreation centers, open space systems and other components of landscape architecture in providing opportunities and benefits for real estate development. Backed by ample literature review, this study reveals the significant relationship between land, real estate and landscape architecture. Landscape architecture which provides an open park and green space can be expanded to benefit the social, environment and economy through optimal used of space in property development project. Hence, this study discusses the objectives which are to determine significant factors in the development of landscape architecture, to identify the importance of landscape architecture in real estate development, and to assess the relationship between landscape architecture and property development land. This study involved 50 respondents from renowned developers; Putrajaya Holdings Sdn Bhd (PJH, Selangor State Development Corporation (PKNS, the local authority; Putrajaya Corporation (PPJ, Kajang Municipal Council (MPKj, relevant agencies; Valuation and Property Services Department-JPPH (Ministry of Finance, Department of Town and Country Planning (Peninsular Malaysia, developers registered with ReHDA and residents / property owners in the study area. To conclude, this study offers adequate benefits to policy makers, also relevant agencies such as the local authorities, landowners, property developers, the relevant professionals and communities on the positive effects and significant relationships between landscape architecture and property development.

  12. Basic design in architectural education in Turkey

    Directory of Open Access Journals (Sweden)

    Makaklı Elif Süyük

    2016-01-01

    Full Text Available Creative activity is one of the most significant parts of architectural education. In the architectural curriculum organisation ‘design studio’ is the unique and preeminent subject. Freshman students encounter ‘design’ first in basic design course, before they know what designing incorporates. The Basic Design is the starting point of initiating creativity in architecture education. It helps each student to understand architecture as a creative and innovative practice in the first year of education. This study analyzes the characteristics of basic design course, the topics of the course contents and its significance in the architectural curriculum in Turkey as well.

  13. Anti-inflammatory effects of eugenol nanoemulsion as a topical delivery system.

    Science.gov (United States)

    Esmaeili, Fariba; Rajabnejhad, Saeid; Partoazar, Ali Reza; Mehr, Shahram Ejtemaei; Faridi-Majidi, Reza; Sahebgharani, Mousa; Syedmoradi, Leila; Rajabnejhad, Mohammad Reza; Amani, Amir

    2016-11-01

    Eugenol is the main constituent of clove oil with anti-inflammatory properties. In this work, for the first time, O/W nanoemulsion of eugenol was designed for the evaluation of anti-inflammatory effects as a topical delivery system. Topical formulations containing 1%, 2% and 4% of eugenol as well as a nanoemulsion system containing 4% eugenol and 0.5% piroxicam were prepared. Further to physicochemical examinations, such as determination of particle size, polydispersity index, zeta potential and physical stability, anti-inflammatory activity was examined in carrageenan-induced paw edema in rats. The optimum formulation was found to contain 2% eugenol (oil phase), 14% Tween 20 (surfactant) and 14% isopropyl alcohol (co-surfactant) in water. Nanoemulsion with polydispersity index of 0.3 and median droplet diameter of 24.4 nm (d50) was obtained. Animal studies revealed that the nanoemulsions exhibited significantly improved anti-inflammatory activity after 1.5 h, compared with marketed piroxicam gel. Additionally, it was shown that increasing the concentration of eugenol did not show higher inhibition of inflammation. Also, the nanoemulsion having piroxicam showed less anti-inflammatory properties compared with the nanoemulsion without piroxicam.

  14. Topical Simvastatin as Host-Directed Therapy against Severity of Cutaneous Leishmaniasis in Mice

    Science.gov (United States)

    Parihar, Suraj P.; Hartley, Mary-Anne; Hurdayal, Ramona; Guler, Reto; Brombacher, Frank

    2016-01-01

    We recently demonstrated that statins mediate protection against intracellular pathogens, Mycobacterium tuberculosis and Listeria monocytogenes in mice. Here, we investigated the immunomodulatory potential of simvastatin as a topical or systemic host-directed drug therapy in controlling inflammatory responses in an experimental mouse model of cutaneous leishmaniasis caused by Leishmania major (LV39). In an ear infection model, topical application of simvastatin directly on established lesions significantly reduced severity of the disease reflected by ear lesion size and ulceration. The host protective effect was further accompanied by decreased parasite burden in the ear and draining lymph nodes in both BALB/c and C57BL/6 mice. Pre-treatment of these mice on a low-fat cholesterol diet and systemic simvastatin also reduced footpad swelling, as well as parasite burdens and ulceration/necrosis in the more robust footpad infection model, demonstrating the prophylactic potential of simvastatin for cutaneous leishmaniasis. Mechanistically, following L. major infection, simvastatin-treated primary macrophages responded with significantly reduced cholesterol levels and increased production of hydrogen peroxide. Furthermore, simvastatin-treated macrophages displayed enhanced phagosome maturation, as revealed by increased LAMP-3 expression in fluorescent microscopy and Western blot analysis. These findings demonstrate that simvastatin treatment enhances host protection against L. major by increasing macrophage phagosome maturation and killing effector functions. PMID:27632901

  15. Generic Architecture for Cloud Infrastructure as a Service (IaaS) Provisioning Model

    NARCIS (Netherlands)

    Demchenko, Y.; Ham, J. van der; Strijkers, R.J.; Ghijsen, M.; Ngo, C.; Cristea, M.

    2011-01-01

    This document provides information about the proposed architectural framework for Cloud Infrastructure as a Service (IaaS) provisioning model that includes the following components: the Composable Services Architecture (CSA) that intends to provide a conceptual and methodological framework for devel

  16. Learning about Teaching the Extracurricular Topic of Nanotechnology as a Vehicle for Achieving a Sustainable Change in Science Education

    Science.gov (United States)

    Blonder, Ron; Mamlok-Naaman, Rachel

    2016-01-01

    This study focused on teachers' transfer of a variety of teaching methods from a teaching module on nanotechnology, which is an example of a topic outside the science curriculum, to teaching topics that are part of the chemistry curriculum. Nanotechnology is outside the science curriculum, but it was used in this study as a means to carry out a…

  17. Architectural Prototyping

    DEFF Research Database (Denmark)

    Bardram, Jakob; Christensen, Henrik Bærbak; Hansen, Klaus Marius

    2004-01-01

    A major part of software architecture design is learning how specific architectural designs balance the concerns of stakeholders. We explore the notion of "architectural prototypes", correspondingly architectural prototyping, as a means of using executable prototypes to investigate stakeholders......' concerns with respect to a system under development. An architectural prototype is primarily a learning and communication vehicle used to explore and experiment with alternative architectural styles, features, and patterns in order to balance different architectural qualities. The use of architectural...... prototypes in the development process is discussed, and we argue that such prototypes can play a role throughout the entire process. The use of architectural prototypes is illustrated by three distinct cases of creating software systems. We argue that architectural prototyping can provide key insights...

  18. Architectural prototyping

    DEFF Research Database (Denmark)

    Bardram, Jakob Eyvind; Christensen, Henrik Bærbak; Hansen, Klaus Marius

    2004-01-01

    A major part of software architecture design is learning how specific architectural designs balance the concerns of stakeholders. We explore the notion of "architectural prototypes", correspondingly architectural prototyping, as a means of using executable prototypes to investigate stakeholders......' concerns with respect to a system under development. An architectural prototype is primarily a learning and communication vehicle used to explore and experiment with alternative architectural styles, features, and patterns in order to balance different architectural qualities. The use of architectural...... prototypes in the development process is discussed, and we argue that such prototypes can play a role throughout the entire process. The use of architectural prototypes is illustrated by three distinct cases of creating software systems. We argue that architectural prototyping can provide key insights...

  19. Evaluation of Topical Preparations Containing Curcuma, Acacia and Lupinus Extracts as an Anti-inflammatory Drugs

    Directory of Open Access Journals (Sweden)

    M M Hamzah

    2011-06-01

    Full Text Available Summary: This work was suggested on the basis of presence of curcuminoids in curcuma and the presence of flavonoidal constituent in acacia and lupinus. The aim of this study was to study their possible anti-inflammatory effect by separately formulation of the three extracts in a suitable gel formula for topical administration and comparison of the prepared gels with a standard gel in the market (diclosal Emulgel by using the carrageenan induced paw edema model in albino rats. The extracts were subjected to phytochemical screening tests using reported methods to determine the presence of various phytoconstituents. Gel formulation was prepared containing 8% of each extract separately in gel base, namely sodium carboxy methyl cellulose (NaCMC. The pharmacological screening revealed that percent reduction of edema produced by curcuma extract was 30.0%, by acacia extract was 4%, by ethanol fraction lupinus was 18% and by chloroform fraction lupinus was 11.3%, while diclofenac sodium topical gel produced 48% reduction of edema. Industrial relevance: Medicinal plants provide a host of chemical compounds, which have been optimized on the basis of their biological activities. Chemical compounds present in medicinal plants have shown great promise in the management of various inflammatory disorders and have continued to serve as alternative and complementary therapies. The present study will help the industry to produce herbal drug effective in the treatment of inflammation with less side effect and less costly when compared to the synthetic drugs.

  20. The Sonic Ambiance as a Transforms Operator of our Cities and our Architecture. The case of autistic children and elderly

    OpenAIRE

    Hussein, Faten; Layeb, Sana; Ghozi, Raja; Jaidane, Mériem

    2016-01-01

    Part of topic : Ambiantal experiences and experiments; International audience; Autistic children and presbycusis elderly are examples of ‘specific’ space users which altered perception of sonic ambiances in particular affects their relationship to the urban and architectural space. Our research is on crossroads of several disciplines. It focuses on analysis of stress levels for those particular populations in some daily situations in urban and architectural spaces, using Electro-Dermal Activi...

  1. International travel as medical research: architecture and the modern hospital.

    Science.gov (United States)

    Logan, Cameron; Willis, Julie

    2010-01-01

    The design and development of the modern hospital in Australia had a profound impact on medical practice and research at a variety of levels. Between the late 1920s and the 1950s hospital architects, administrators, and politicians travelled widely in order to review the latest international developments in the hospital field They were motivated by Australia's geographic isolation and a growing concern with how to govern the population at the level of physical health. While not 'medical research' in the conventional sense of the term, this travel was a powerful generator of medical thinking in Australia and has left a rich archival legacy. This paper draws on that archive to demonstrate the ways in which architectural research and international networks of hospital specialists profoundly shaped the provision of medical infrastructure in Australia.

  2. To Knit a Wall, knit as matrix for composite materials for architecture

    DEFF Research Database (Denmark)

    Ramsgaard Thomsen, Mette; Hicks, Toni

    2008-01-01

    ), para aramids(Kevlar) and carbon fibre, as well as the new industrialisedand computer controlled fabrication techniques, thispaper examines how advanced technical textiles couldoffer new architectural solutions. Discussing newcomputer aided design (CAD) solutions for developingcomplex surfaces...

  3. Assessment of topical versus oral ivermectin as a treatment for head lice.

    Science.gov (United States)

    Ahmad, Hesham M; Abdel-Azim, Eman S; Abdel-Aziz, Rasha T

    2014-01-01

    Many medications are available for treatment of pediculosis capitis including ivermectin. Our aim is to compare the efficacy and safety of topical versus oral ivermectin in treatment of pediculosis capitis. Sixty-two patients with proved head lice infestation were included and divided into group I (31 patients; received single topical application of 1% ivermectin) and group II (31 patients; received single dose of oral ivermectin). Treatment was repeated after 1 week for nonresponders. At 1 week after treatment, the eradication rates and improvement of pruritus were significantly higher among patients who received topical than oral ivermectin. When a second treatment, topical or oral, was given to nonresponders, the cure rates of infestation and pruritus was 100% and 97% among patients treated with topical and oral ivermectin, respectively with no significant difference between the two groups. This study suggests that both topical and oral ivermectin demonstrate high efficacy and tolerability in treatment of pediculosis capitis. However, a single treatment with topical ivermectin provides significantly higher cure of infestation and faster relief of pruritus than oral ivermectin. In addition, whether topical or oral ivermectin is used to treat head lice, a second dose is required in some cases to ensure complete eradication.

  4. An architecture and protocol for communications satellite constellations regarded as multi-agent systems

    Science.gov (United States)

    Lindley, Craig A.

    1995-01-01

    This paper presents an architecture for satellites regarded as intercommunicating agents. The architecture is based upon a postmodern paradigm of artificial intelligence in which represented knowledge is regarded as text, inference procedures are regarded as social discourse and decision making conventions and the semantics of representations are grounded in the situated behaviour and activity of agents. A particular protocol is described for agent participation in distributed search and retrieval operations conducted as joint activities.

  5. An architecture and protocol for communications satellite constellations regarded as multi-agent systems

    Science.gov (United States)

    Lindley, Craig A.

    1995-05-01

    This paper presents an architecture for satellites regarded as intercommunicating agents. The architecture is based upon a postmodern paradigm of artificial intelligence in which represented knowledge is regarded as text, inference procedures are regarded as social discourse and decision making conventions and the semantics of representations are grounded in the situated behaviour and activity of agents. A particular protocol is described for agent participation in distributed search and retrieval operations conducted as joint activities.

  6. Gaining trust as well as respect in communicating to motivated audiences about science topics.

    Science.gov (United States)

    Fiske, Susan T; Dupree, Cydney

    2014-09-16

    Expertise is a prerequisite for communicator credibility, entailing the knowledge and ability to be accurate. Trust also is essential to communicator credibility. Audiences view trustworthiness as the motivation to be truthful. Identifying whom to trust follows systematic principles. People decide quickly another's apparent intent: Who is friend or foe, on their side or not, or a cooperator or competitor. Those seemingly on their side are deemed warm (friendly, trustworthy). People then decide whether the other is competent to enact those intents. Perception of scientists, like other social perceptions, involves inferring both their apparent intent (warmth) and capability (competence). To illustrate, we polled adults online about typical American jobs, rated as American society views them, on warmth and competence dimensions, as well as relevant emotions. Ambivalently perceived high-competence but low-warmth, "envied" professions included lawyers, chief executive officers, engineers, accountants, scientists, and researchers. Being seen as competent but cold might not seem problematic until one recalls that communicator credibility requires not just status and expertise but also trustworthiness (warmth). Other research indicates the risk from being enviable. Turning to a case study of scientific communication, another online sample of adults described public attitudes toward climate scientists specifically. Although distrust is low, the apparent motive to gain research money is distrusted. The literature on climate science communicators agrees that the public trusts impartiality, not persuasive agendas. Overall, communicator credibility needs to address both expertise and trustworthiness. Scientists have earned audiences' respect, but not necessarily their trust. Discussing, teaching, and sharing information can earn trust to show scientists' trustworthy intentions.

  7. Biomimicry as an approach for sustainable architecture case of arid regions with hot and dry climate

    Science.gov (United States)

    Bouabdallah, Nabila; M'sellem, Houda; Alkama, Djamel

    2016-07-01

    This paper aims to study the problem of thermal comfort inside buildings located in hot and arid climates. The principal idea behind this research is using concepts based on the potential of nature as an instrument that helps creating appropriate facades with the environment "building skin". The biomimetic architecture imitates nature through the study of form, function, behaviour and ecosystems of biological organisms. This research aims to clarify the possibilities that can be offered by biomimicry architecture to develop architectural bio-inspired building's design that can help to enhance indoor thermal ambiance in buildings located in hot and dry climate which helps to achieve thermal comfort for users.

  8. Physical Carboxymethylscleroglucan/Calcium Ion Hydrogels as Modified Drug Delivery Systems in Topical Formulations

    Directory of Open Access Journals (Sweden)

    Maria Antonietta Casadei

    2009-07-01

    Full Text Available A carboxymethyl derivative of scleroglucan (Scl-CM with a 65±5% carboxylic group degree of derivatization (DD was recently synthesized and characterized. Aqueous solutions of the polymer underwent to a sharp transition toward a gel like behaviour in the presence of divalent ions such as Ca+2. Physical hydrogels with different Scl-CM/Ca+2 ratios were prepared and characterized for their rheological behaviour. Their potential as drug delivery systems was also evaluated. To this end three non steroidal anti-inflammatory drugs (NSAIDs were loaded into the hydrogels obtained with 2% w/v solution of Scl-CM and 0.05 and 0.1 M CaCl2. The release rate of the drugs was critically related to the salt concentration. By an appropriate combination of the hydrogels prepared using different amounts of salt, it was possible to obtain a system able to release diclofenac with zero-order kinetics. Primary skin irritation tests showed a good biocompatibility of the new polymer, as well as of its hydrogels. These results suggest a potential of the new hydrogels for the development of modified delivery systems in topical formulations.

  9. Topical issues of functioning a region as a social-economic system

    Directory of Open Access Journals (Sweden)

    Roman Andreyevich Timofeyev

    2015-09-01

    Full Text Available Objective to identify the topical issues of forming a region as a socialeconomic system. Methods systematic approach based on general scientific methods of empirical and theoretical research such as observation and comparison analysis and synthesis induction and deduction as well as comparativehistorical method statistical methods macroeconomic analysis. Results the major issues of applying a systematic approach to the analysis of the region as a socioeconomic system were explored and analyzed. The authors proved the most important features of the system considered different points of view on the content of the region as a system category analyzed the basic paradigm of the region functioning identified specific properties inherent to the region as a system conducted analysis of the modern Russian and foreign literature which showed that at present there is no consensus about the structural content of the region as an economic system at mesolevel suggested the authorsrsquo definition of the region category conclusions were made about the applicability of systematic approach to analyzing a region as a socioeconomic system. Scientific novelty the trends and problems of the region formation as an economic system were specifiedin the form of components of a single social and economic system the conceptual scheme for the region development as a socioeconomic system at mesolevel was proposed the author39s definition of the regionwas given. The suggested conceptual framework focuses on regional subsystems each of which is characterized by resources capacity the effective use of which is intended to ensure the sustainable and competitive territory development while increasing the quality of life of the population under federalism and globalization. Practical significance conclusions and suggestions can be used by public authorities in the strategic policy development for the effective management of the Russian regions. nbsp

  10. Architecture on Architecture

    DEFF Research Database (Denmark)

    Olesen, Karen

    2016-01-01

    that is not scientific or academic but is more like a latent body of data that we find embedded in existing works of architecture. This information, it is argued, is not limited by the historical context of the work. It can be thought of as a virtual capacity – a reservoir of spatial configurations that can...... the obligation to prepare students to perform in a profession that is largely defined by forces outside that discipline. It will be proposed that the autonomy of architecture can be understood as a unique kind of information: as architecture’s self-reliance or knowledge-about itself. A knowledge...... be transformed and reapplied endlessly through its confrontation with shifting information from outside the realms of architecture. A selection of architects’ statements on their own work will be used to demonstrate how in quite diverse contemporary practices the re-use of existing architectures is applied...

  11. Fractional brownian functions as mathematical models of natural rhythm in architecture.

    Science.gov (United States)

    Cirovic, Ivana M

    2014-10-01

    Carl Bovill suggested and described a method of generating rhythm in architecture with the help of fractional Brownian functions, as they are mathematical models of natural rhythm. A relationship established in the stated procedure between fractional Brownian functions as models of rhythm, and the observed group of architectural elements, is recognized as an analogical relationship, and the procedure of generating rhythm as a process of analogical transfer from the natural domain to the architectural domain. Since analogical transfer implies relational similarity of two domains, and the establishment of one-to-one correspondence, this paper is trying to determine under which conditions such correspondence could be established. For example, if the values of the observed visual feature of architectural elements are not similar to each other in a way in which they can form a monotonically increasing, or a monotonically decreasing bounded sequence, then the structural alignment and the one-to-one correspondence with a single fractional Brownian function cannot be established, hence, this function is deemed inappropriate as a model for the architectural rhythm. In this case we propose overlapping of two or more functions, so that each of them is an analog for one subset of mutually similar values of the visual feature of architectural elements.

  12. Mesoporous silica as a carrier for topical application: the Trolox case study.

    Science.gov (United States)

    Gastaldi, L; Ugazio, E; Sapino, S; Iliade, P; Miletto, I; Berlier, G

    2012-08-28

    As part of a recent research effort aimed at employing mesoporous materials for controlled drug delivery, this paper presents MCM-41 as a carrier for topical application, using Trolox as a model unstable guest molecule. The complexes between Trolox and MCM-41 were prepared by employing different inclusion procedures, varying solvent, method and pretreatment of the silica matrix. The objectives of this study were to determine Trolox loading, analyze its integrity and availability after immobilization on mesoporous silica, evaluate MCM-41 influence on Trolox photodegradation and establish whether the preparation method significantly influences complex properties. The characterization analyses (XRD, TGA, DSC and FTIR) confirmed the hydrogen-bonding interaction and Trolox structure preservation. Gas-volumetric analysis showed a consistent decrease in surface area and in pore volume and diameter with respect to bare MCM-41 indicating that Trolox was mainly located within mesopores. In vitro diffusion tests showed a slower release of Trolox after inclusion in the MCM-41 matrix; at the same time UV irradiation studies highlighted an increased photostability for the complex particularly in O/W emulsion. Moreover the radical scavenging activity of Trolox was maintained after immobilization. In all cases, differences were observed in all tested samples, suggesting that results could be optimized by modifying the inclusion procedure and by improving the guest loading.

  13. Asian Eocene monsoons as revealed by leaf architectural signatures

    Science.gov (United States)

    Spicer, Robert A.; Yang, Jian; Herman, Alexei B.; Kodrul, Tatiana; Maslova, Natalia; Spicer, Teresa E. V.; Aleksandrova, Galina; Jin, Jianhua

    2016-09-01

    The onset and development of the Asian monsoon systems is a topic that has attracted considerable research effort but proxy data limitations, coupled with a diversity of definitions and metrics characterizing monsoon phenomena, have generated much debate. Failure of geological proxies to yield metrics capable of distinguishing between rainfall seasonality induced by migrations of the Inter-tropical Convergence Zone (ITCZ) from that attributable to topographically modified seasonal pressure reversals has frustrated attempts to understand mechanisms underpinning monsoon development and dynamics. Here we circumvent the use of such single climate parameter metrics in favor of detecting directly the distinctive attributes of different monsoon regimes encoded in leaf fossils. Leaf form adapts to the prevailing climate, particularly under the extreme seasonal stresses imposed by monsoons, so it is likely that fossil leaves carry a unique signature of past monsoon regimes. Leaf form trait spectra obtained from fossils from Eocene basins in southern China were compared with those seen in modern leaves growing under known climate regimes. The fossil leaf trait spectra, including those derived from previously published fossil floras from northwestern India, were most similar to those found in vegetation exposed to the modern Indonesia-Australia Monsoon (I-AM), which is largely a product of seasonal migrations of the ITCZ. The presence of this distinctive leaf physiognomic signature suggests that although a monsoon climate existed in Eocene time across southern Asia the characteristics of the modern topographically-enhanced South Asia Monsoon had yet to develop. By the Eocene leaves in South Asia had become well adapted to an I-AM type regime across many taxa and points to the existence of a pervasive monsoon climate prior to the Eocene. No fossil trait spectra typical of exposure to the modern East Asia monsoon were seen, suggesting the effects of this system in southern

  14. Architecture as a technology of framing experience : camera obscura, camp, and the confessional

    OpenAIRE

    Uysal, V Şafak

    2009-01-01

    Ankara : The Department of Interior Architecture and Environmental Design and the Institute of Economics and Social Sciences of Bilkent University, 2009. Thesis (Ph.D.) -- Bilkent University, 2009. Includes bibliographical references leaves 149-163 Throughout architectural history, the problematic of experience is mostly addressed within the confines of either deterministic or phenomenological models. Bound as they are, however, to the transcendental coordinates of a founding s...

  15. Writing Gardens - Gardening Drawings: Fung, Brunier and Garening as a model of Landscape Architectural Practice

    Directory of Open Access Journals (Sweden)

    Julian Raxworthy

    2004-06-01

    Full Text Available Landscape architecture is different from other design discourses, notably architecture, because of its utilisation of' dynamic' construction media such as plant materials, soils and water, compared with the 'static' materials of architecture, colloquially described as bricks and mortar. This dynamism refers to the fact that landscape materials not only change, but get better over time. While this is a material difference, its implications extend to practice, which has been modelled, from architecture, to favour a static mode of representation: the drawing. While the drawing is important for the propositional nature of landscape architecture, it may be valuable to look at other disciplines, allied to landscape architecture, which might be seen as better able to engage with change. In this essay, the garden provides just such an example. In the writings of Stanislaus Fung on the Chinese garden text the Yuan vi, an argument is made about writing being a fundamental act in the endeavour of gardening that may offer a bridge across the 'ontological disparity' that exists between representation and the subject, the landscape. To speak of writing in this context suggests that writing about gardens is actually a type of gardening in itself. This argument is extended in the current essay quickly to see if it is also appropriate to consider drawings in this way. This essay also attempts to legitimate theoretically the real possibility of modifying landscape architectural practices to engage with change, by suggesting what might be learned from gardening. In further research by this author, this argument will be used as the theoretical basis for critiquing gardens in such a way that lessons learnt from garden designers can be valuably incorporated back into the discourse of landscape architecture.

  16. Topical anesthesia

    Directory of Open Access Journals (Sweden)

    Mritunjay Kumar

    2015-01-01

    Full Text Available Topical anesthetics are being widely used in numerous medical and surgical sub-specialties such as anesthesia, ophthalmology, otorhinolaryngology, dentistry, urology, and aesthetic surgery. They cause superficial loss of pain sensation after direct application. Their delivery and effectiveness can be enhanced by using free bases; by increasing the drug concentration, lowering the melting point; by using physical and chemical permeation enhancers and lipid delivery vesicles. Various topical anesthetic agents available for use are eutectic mixture of local anesthetics, ELA-max, lidocaine, epinephrine, tetracaine, bupivanor, 4% tetracaine, benzocaine, proparacaine, Betacaine-LA, topicaine, lidoderm, S-caine patch™ and local anesthetic peel. While using them, careful attention must be paid to their pharmacology, area and duration of application, age and weight of the patients and possible side-effects.

  17. Impacts of traditional architecture on the use of wood as an element of facade covering in Serbian contemporary architecture

    Directory of Open Access Journals (Sweden)

    Ivanović-Šekularac Jelena

    2011-01-01

    Full Text Available The world trend of re-use of wood and wood products as materials for construction and covering of architectural structures is present not only because of the need to meet the aesthetic, artistic and formal requirements or to seek inspiration in the return to the tradition and nature, but also because of its ecological, economic and energetic feasibility. Furthermore, the use of wood fits into contemporary trends of sustainable development and application of modern technical and technological solutions in the production of materials, in order to maintain a connection to nature, environment and tradition. In this study the author focuses on wood and wood products as an element of facade covering on buildings in our country, in order to extend knowledge about possibilities and limitations of their use and create a base for their greater and correct application. The subject of this research is to examine the application of wood and wood products as an element covering the exterior in combination with other materials applied in our traditional and contemporary homes with the emphasis on functional, representational art and the various possibilities of wood. In this study all the factors that affect the application of wood and wood products have been analyzed and the conclusions have been drawn about the manner of their implementation and the types of wood and wood products protection. The development of modern technological solutions in wood processing led to the production of composite materials based on wood that are highly resistant, stable and much longer lasting than wood. Those materials have maintained in an aesthetic sense all the characteristics of wood that make it unique and inimitable. This is why modern facade coating based on wood should be applied as a facade covering in the exterior of modern architectural buildings in Serbia, and the use wood reduced to a minimum.

  18. Working Capital Management as a routine: An action based access to the topic

    Directory of Open Access Journals (Sweden)

    Petra Kroflin

    2015-10-01

    Full Text Available In times of unstable capital markets on the one side and historically low interests on the other, working capital management must be discussed from different perspectives. Limited sources of liquidity, and the high refinancing risk of lending companies, make the reduction of current assets and liabilities an even more important management task than before. On the other hand, low interest rates raise the need for defining the optimum level for working capital. Little research and empirical evidence exists when it comes to lifting working capital targets to create value. The objective of the present paper is to give evidence on whether German companies adapt their behavior in terms of handling working capital in the actual economic environment and to describe which practices have been established to perform this adaptation. The given analysis is based on a qualitative study. The data used have been gathered in 2014 and 2015 during semi structured interviews with CFOs or financial executives of 15 German and Austrian industrial firms. Our study suggests that adaptation is realized rather by moderating management attention and focus to the topic of capital cost but not by adjusting the financial targets themselves. This is because working capital reduction as become a management routine.

  19. Topical treatment with propranolol gel as a supplement to the existing treatment of hemangiomas

    Institute of Scientific and Technical Information of China (English)

    Markus Schneider; Andreas Reimer; Hansjoerg Cremer; Peter Ruef

    2014-01-01

    Background: Systemic treatment with propranolol is proven to be effective for patients with hemangiomas with less side-effect. We used a propranolol gel for topical use on hemangiomas. Methods: In this retrospective study, we analyzed 148 patients who had been treated topically with propranolol gel for 12 weeks. We analyzed the data of patients and clinically gave each hemangioma a "hemangioma score" to determine the treatment success. Results: In 147 of the 148 patients, strong signs of resolution under treatment included lightening, paling, and less vascularization. The hemangioma score showed a signifi cant decrease during the treatment. Relevant serum levels of propranolol were not found. Adverse effects were rare and not related to propranolol. Conclusion: Topical treatment with propranolol gel is suitable for specific hemangiomas in addition to cryotherapy and systemic treatment with propranolol.

  20. Efficacy of 2% Lidocaine Injection as a Topical Agent in Cataract Surgery

    Institute of Scientific and Technical Information of China (English)

    Wenyong Huang; Bin Liu; Jiewei Liu; Jinxing Xu; Zhende Lin

    2003-01-01

    Purpose: To determine whether 2% Lidocaine injection is an effective topical anesthetic agent for non-phaco small incision cataract surgery.Setting: Charity eye clinic supported by Hellen Keller International.Methods:One hundred and twenty-five consecutive cataract surgery patients received topical anesthesia with 2% Lidocaine injection solution just 1 and 0.5 minutes prior to non-phaco small incision cataract extraction and intraocular lens implantation. Each patient was asked about pain or piessure sensation during the operation.Results: The surgeon felt ease in the operations. Many patients (93/125) were comfort during the whole surgery. Only 9 patients′ score was above level 3,mostly complained during the nucleus extraction; Among those whose score was level 1~2, 82.6%(19/23)claimed discomfort at middle of the operation (nucleus extraction) or the beginning (creating the conjunctival flap).Conclusion: Lidocaine injection solution(2%) was an effective topical anesthesia agent in cataract surgery.

  1. Nanostructured lipid carriers as robust systems for topical lidocaine-prilocaine release in dentistry.

    Science.gov (United States)

    Ribeiro, Lígia N M; Franz-Montan, Michelle; Breitkreitz, Márcia C; Alcântara, Ana C S; Castro, Simone R; Guilherme, Viviane A; Barbosa, Raquel M; de Paula, Eneida

    2016-10-10

    In dental practice, local anesthesia causes pain, fear, and stress, and is frequently the reason that patients abandon treatment. Topical anesthetics are applied in order to minimize the discomfort caused by needle insertion and injection, and to reduce the symptoms of superficial trauma at the oral mucosa, but there are still no efficient commercially available formulations. Factorial design is a multivariate data analysis procedure that can be used to optimize the manufacturing processes of lipid nanocarriers, providing valuable information and minimizing development time. This work describes the use of factorial design to optimize a process for the preparation of nanostructured lipid carriers (NLC) based on cetyl palmitate and capric/caprylic triglycerides as structural lipids and Pluronic 68 as the colloidal stabilizer, for delivery of the local anesthetics lidocaine and prilocaine (both at 2.5%). The factors selected were the excipient concentrations, and three different responses were followed: particle size, polydispersity index and zeta potential. The encapsulation efficiency of the most effective formulations (NLC 2, 4, and 6) was evaluated by the ultrafiltration/centrifugation method. The formulations that showed the highest levels of encapsulation were tested using in vitro release kinetics experiments with Franz diffusion cells. The NLC6 formulation exhibited the best sustained release profile, with 59% LDC and 66% PLC released after 20h. This formulation was then characterized using different techniques (IR-ATR, DSC, DRX, TEM, and NTA) to obtain information about its molecular organization and its physicochemical stability, followed during 14months of storage at 25°C. This thorough pre-formulation study represents an important advance towards the development of an efficient pre-anesthetic for use in dentistry.

  2. Bimatoprost Topical

    Science.gov (United States)

    Topical bimatoprost is used to treat hypotrichosis (less than the normal amount of hair) of the eyelashes by promoting ... growth of longer, thicker, and darker lashes. Topical bimatoprost is in a class of medications called prostaglandin ...

  3. Topical Pimecrolimus as a New Optional Treatment in Cutaneous Sarcoidosis of Lichenoid Type

    Directory of Open Access Journals (Sweden)

    Antonella Tammaro

    2014-01-01

    Full Text Available We report the case of cutaneous sarcoidosis of lichenoid type successfully treated with pimecrolimus. For the first time in the literature, we propose the use of this topical calcineurin inhibitor for the treatment of the cases refractory to common therapy regimens.

  4. In vitro analysis of polyurethane foam as a topical hemostatic agent

    NARCIS (Netherlands)

    Broekema, Ferdinand I.; van Oeveren, Wim; Zuidema, Johan; Visscher, Susan H.; Bos, Rudolf R. M.

    2011-01-01

    Topical hemostatic agents can be used to treat problematic bleedings in patients who undergo surgery. Widely used are the collagen- and gelatin-based hemostats. This study aimed to develop a fully synthetic, biodegradable hemostatic agent to avoid exposure to animal antigens. In this in vitro study

  5. Experiences of Teaching the Heat Energy Topic in English as a Second Language

    Science.gov (United States)

    Halim, Lilia; Dahlan, Fathiyah; Treagust, David F.; Chandrasegaran, A. L.

    2012-01-01

    In view of the current debate in Malaysia about the teaching of science and mathematics in English, a qualitative study was undertaken involving a purposeful sampling of three non-physics teachers to ascertain how well equipped they were with the necessary pedagogical content knowledge relating to the teaching of the topic of "heat…

  6. Oral Language Development as a Precursor to Literacy. ERIC Topical Bibliography and Commentary.

    Science.gov (United States)

    Smith, Carl B., Ed.

    Research suggests that oral language development is directly related to literacy, and is crucial for success in learning to be literate. This topical bibliography and commentary discusses language acquisition theories, components of language, phonology in literacy, and a first-grade classroom study that explored "literate talk" in the classroom…

  7. Development of terbinafine solid lipid nanoparticles as a topical delivery system

    Directory of Open Access Journals (Sweden)

    Chen Y-C

    2012-08-01

    was higher than that of Lamisil® OnceTM at 12 hours, and it was almost the same as that of Lamisil® OnceTM at 24 hours. It was concluded that the application of ACP1-GM1 for 12 hours might have an efficacy comparable to that of Lamisil® OnceTM for 24 hours, which would resolve the practical problem of the longer administration period that is necessary for Lamisil® OnceTM.Keywords: terbinafine, solid lipid nanoparticle, topical delivery system

  8. Foundations for Tools as a Service Workspace: A Reference Architecture

    DEFF Research Database (Denmark)

    Chauhan, Muhammad Aufeef

    2016-01-01

    Nowadays, on-demand provisioning of computing resources following a payper- use service model have enabled client organizations to have easy and on the fly access to the resources. The resources that are provisioned using the service model are generally characterized as resource as a Service (*aa......S). However, providing the resources corresponding to a domain following *aaS requires specific challenges associated with the domain to be addressed. Software as a Service (SaaS) model enables software vendors to offer their software solutions to end users following pay-per-use model. SaaS also enables end....... This dissertation presents an approach to provide Tools as a service workSPACE (TSPACE), which is characterized as provisioning of a bundled suite of Tools as a Service (TaaS) required to perform activities associated with a specific domain as part of a cloud-enabled workspace. The presented approach is focused...

  9. Modelling of internal architecture of kinesin nanomotor as a machine language.

    Science.gov (United States)

    Khataee, H R; Ibrahim, M Y

    2012-09-01

    Kinesin is a protein-based natural nanomotor that transports molecular cargoes within cells by walking along microtubules. Kinesin nanomotor is considered as a bio-nanoagent which is able to sense the cell through its sensors (i.e. its heads and tail), make the decision internally and perform actions on the cell through its actuator (i.e. its motor domain). The study maps the agent-based architectural model of internal decision-making process of kinesin nanomotor to a machine language using an automata algorithm. The applied automata algorithm receives the internal agent-based architectural model of kinesin nanomotor as a deterministic finite automaton (DFA) model and generates a regular machine language. The generated regular machine language was acceptable by the architectural DFA model of the nanomotor and also in good agreement with its natural behaviour. The internal agent-based architectural model of kinesin nanomotor indicates the degree of autonomy and intelligence of the nanomotor interactions with its cell. Thus, our developed regular machine language can model the degree of autonomy and intelligence of kinesin nanomotor interactions with its cell as a language. Modelling of internal architectures of autonomous and intelligent bio-nanosystems as machine languages can lay the foundation towards the concept of bio-nanoswarms and next phases of the bio-nanorobotic systems development.

  10. Design studios as research: an emerging paradigm for landscape architecture

    Directory of Open Access Journals (Sweden)

    Helen Armstrong

    1999-10-01

    Full Text Available This paper explores the scholarship in creative works and design studios. It examines the particular research methods associated with scholarship in creative works, including reflective practice and hermeneutics. The methodological considerations include comparisons between triangulation and crystallisation as tests for rigour, and the essential role of peer review and publication. The paper concludes with a suite of new landscape design studios with research potential. They include studios as part of larger research projects, and studios which are creative works in their own right where metaphor, trope and a form of avant-gardism are deployed to bring about a form of new knowledge.

  11. The human heart and the circulatory system as an interesting interdisciplinary topic in lessons of physics and biology

    Science.gov (United States)

    Volná, M.; Látal, F.; Kubínek, R.; Richterek, L.

    2014-01-01

    Many topics which are closely related can be found in the national curriculum of the Czech Republic for physics and biology. One of them is the heart and the circulatory system in the human body. This topic was examined cross curriculum, a teaching module was created and the topic was chosen for our research. The task was to determine if the students of bachelor study are aware of connections between physics and biology within this topic and whether we can help them effectively to describe the corresponding physics phenomena in the human body connected, for example, with a heart attack or with the measurement of blood pressure. In this paper, the heart and the circulatory system are presented as suitable topics for an interdisciplinary teaching module which includes both theoretical and experimental parts. The module was evaluated by a group of first-year undergraduate students of physics at the Faculty of Science, Palacký University. The acquired knowledge was compared with another control group through a test. The highest efficiency of the module was evaluated on the basis of questions that covered the calculation problems.

  12. Advance Billing and Metering Architecture for Infrastructure as a Service

    Directory of Open Access Journals (Sweden)

    Sukhpal Singh

    2013-01-01

    Full Text Available Billing in Infrastructure as a Service (IaaS is a complex task that is often compromised due to lack of various interactions (Consumer, Provider, Budget Manager, Agent and Online Payment simultaneously along with necessary features like discount, tax, plan etc. Until Billing is considered as a last essential ability, appropriate framework cannot be provided to IaaS cloud consumers. In this paper, IaaS Online Billing System (IOBS has been proposed that describes transparency of consumption, billing and frequency of usage of services for a cloud based pay per use system. This system describes various interactions of network and user interface. The billing rules have been stored in a database. The model has been verified through UML that demonstrates that IOBS is effective in improving user interaction by reducing time and increasing customer satisfaction.

  13. Open Architecture as an Enabler for FORCEnet Cruise Missile Defense

    Science.gov (United States)

    2007-09-01

    battlespace via the FORCEnet information network. Current capability gaps include a lack of common configuration and Fire Control Quality ( FCQ ...connectivity among platforms that is needed to achieve and maintain a robust cruise missile defense. FCQ is defined as data obtained with the sufficient...platform, or a combination of the two. With Fire Control Quality ( FCQ ) threat data from a remote sensor, the remote unit can initiate a launch

  14. Architecture as a Tool for Branding in Rural Istrian Tourism Destination

    Directory of Open Access Journals (Sweden)

    Ivana Medica

    2010-06-01

    Full Text Available Natural and protected environments with authentic widespread traditional construction have become one of the fundamental touristic resources. Traditional architecture is a very crucial part of collective cultural heritage. Although it is ample and widespread, only since recent times it has been given its economical value as well as it has been included in tourism. According to the context above, authors have come up with a hypothesis stating that with implying branding of traditional architectural heritage, a positive influence on enrichment of touristic offerings of certain destination will be achieved. The authors defend and fulfill their hypothesis by analyzing different research on the example of rural destinations in Istria.

  15. Enterprise architecture as tool for managing operational complexity in organizations

    Directory of Open Access Journals (Sweden)

    Martín Dario Arango-Serna

    2014-01-01

    Full Text Available Diferentes tipos de empresas alrededor del mundo, sin importar su tamaño, ni su actividad económica, ni su naturaleza y el capital que manejan, entre otros aspectos, enfrentan en su día a día, retos de diferente índole que deben ser atendidos de manera ágil para poder competir de forma exitosa en un mundo globalizado y que opera bajo entornos altamente dinámicos. En este sentido, cada vez toma mayor relevancia el hecho de que, a nivel del funcionamiento interno, las organizaciones deben estar lo suficientemente preparadas para dar respuesta de forma eficiente, ágil e innovadora a los retos y necesidades que se presentan. Este artículo plantea la importancia que representan las tecnologías de información y el desarrollo de un modelo de arquitectura empresarial, como instrumentos que permiten a las empresas afrontar los retos asociados con la complejidad que se presenta en una organización en su entorno operativo.

  16. The emergence and institutional co-determination of sustainability as a teaching topic in interdisciplinary science teacher education

    DEFF Research Database (Denmark)

    Rasmussen, Klaus

    2016-01-01

    This paper takes an institutional perspective on the topic of sustainability in order to analyse how this ‘idea’ enters science teacher education through an interdisciplinary approach. It shows how the development and implementation of a course for Danish pre-service teachers was conditioned......, conceptualised through a new reference model that separates the analysis from the usual sustainability dimensions. The findings reveal how sustainability as a teaching topic can be a unifying idea in an interdisciplinary setting. Disciplinary differences evidently impact course planning and implementation...

  17. Architectural freedom and industrialised architecture

    DEFF Research Database (Denmark)

    Vestergaard, Inge

    2012-01-01

    compares "best practice" in Denmark and "best practice" in Austria. The modern architects accepted the fact that industrialized architecture told the storey of repetition and monotonous as basic condition. This article aims to explain that architecture can be thought as a complex and diverse design through......Architectural freedom and industrialized architecture. Inge Vestergaard, Associate Professor, Cand. Arch. Aarhus School of Architecture, Denmark Noerreport 20, 8000 Aarhus C Telephone +45 89 36 0000 E-mai l inge.vestergaard@aarch.dk Based on the repetitive architecture from the "building boom" 1960...... to 1973 it is discussed how architects can handle these Danish element and montage buildings through the transformation to upgraded aesthetical, functional and energy efficient architecture. The method used is analysis of cases, parallels to literature studies and producer interviews. This analysis...

  18. Supporting Undergraduate Computer Architecture Students Using a Visual MIPS64 CPU Simulator

    Science.gov (United States)

    Patti, D.; Spadaccini, A.; Palesi, M.; Fazzino, F.; Catania, V.

    2012-01-01

    The topics of computer architecture are always taught using an Assembly dialect as an example. The most commonly used textbooks in this field use the MIPS64 Instruction Set Architecture (ISA) to help students in learning the fundamentals of computer architecture because of its orthogonality and its suitability for real-world applications. This…

  19. Severe hyperkalemia as a complication of timolol, a topically applied beta-adrenergic antagonist

    Energy Technology Data Exchange (ETDEWEB)

    Swenson, E.R.

    1986-06-01

    Severe hyperkalemia occurred in a patient with radiation pneumonitis and glaucoma shortly after beginning prednisone therapy. There was no evidence of renal failure, diabetes, acidosis, increased potassium intake, or significant tissue trauma. Medications having adverse effects on potassium metabolism were considered, and the patient's use of timolol maleate eyedrops was discontinued. His serum potassium level normalized despite continuation of the prednisone therapy. He became hyperkalemic on rechallenge with timolol and normokalemic following its withdrawal. This case indicates that the potential for beta-blocker-induced hyperkalemia exists even with topical appreciation.

  20. Topical Drugs for Pain Relief

    Directory of Open Access Journals (Sweden)

    Anjali Srinivasan

    2015-03-01

    Full Text Available Topical therapy helps patients with oral and perioral pain problems such as ulcers, burning mouth syndrome, temporomandibular disorders, neuromas, neuropathies and neuralgias. Topical drugs used in the field of dentistry are topical anaesthetics, topical analgesics, topical antibiotics and topical corticosteroids. It provides symptomatic/curative effect. Topical drugs are easy to apply, avoids hepatic first pass metabolism and more sites specific. But it can only be used for medications that require low plasma concentrations to achieve a therapeutic effect.

  1. Topical Drugs for Pain Relief

    OpenAIRE

    Anjali Srinivasan; Prashanth Shenai; Laxmikanth Chatra; Veena KM; Prasanna Kumar Rao

    2015-01-01

    Topical therapy helps patients with oral and perioral pain problems such as ulcers, burning mouth syndrome, temporomandibular disorders, neuromas, neuropathies and neuralgias. Topical drugs used in the field of dentistry are topical anaesthetics, topical analgesics, topical antibiotics and topical corticosteroids. It provides symptomatic/curative effect. Topical drugs are easy to apply, avoids hepatic first pass metabolism and more sites specific. But it can only be used for medications that ...

  2. A Process Framework for Designing Software Reference Architectures for Providing Tools as a Service

    DEFF Research Database (Denmark)

    Chauhan, Muhammad Aufeef; Babar, Muhammad Ali; Probst, Christian W.

    2016-01-01

    Software Reference Architecture (SRA), which is a generic architecture solution for a specific type of software systems, provides foundation for the design of concrete architectures in terms of architecture design guidelines and architecture elements. The complexity and size of certain types of s...

  3. The Concept of the Interculture in Time: (Intercultural Topics in Textbooks of French as a Foreign Language

    Directory of Open Access Journals (Sweden)

    Meta Lah

    2012-12-01

    Full Text Available The article deals with the concept of interculturality as used in foreign language didactics. In accordance with the definition of interculturality given in the first part of the article, two categories are included in the analysis – two “levels” of culture, each of them bearing a different name in literature, namely high and popular culture. Various textbooks used for teaching French as a foreign language in Slovenia in both the past and present were chosen for the analysis of topics that cover a fairly long period of time – among them the textbooks by two Slovenian authors: Južnič (1938 and Grad (1954, as well as some generally-used French textbooks, such as Cours de langue et de civilisation françaises (1953, Le nouveau sans frontières (1988 and Nouveau rond point (2011. The article is based on the hypothesis that high culture is more likely to be present in the older textbooks, which are based on traditional methods, whereas in modern textbooks more popular, everyday topics can be found. It is also presumed that topics in modern textbooks are, compared to their more traditional counterparts, introduced in an intercultural manner which could encourage students to compare the culture of the foreign country with their own. Both hypotheses are partly confirmed. In Slovenian textbooks there are very few culture-based topics. On the other hand, they are present in all French textbooks, regardless of the methodology. It is true that Mauger introduces more high culture than the others and that the intercultural topics are presented only in the most recent textbook. In all the others, it is exclusively the culture of the target country that is introduced.

  4. An architecture to offer cloud-based radio access network as a service

    NARCIS (Netherlands)

    Studer Ferreira, Lucio; Pichon, Dominique; Hatefi, Atoosa; Gomes, Andre; Dimitrova, Desislava; Braun, Torsten; Karagiannis, Georgios; Karimzadeh, Morteza; Branco, Monica; Correia, Luis M.

    2014-01-01

    This paper addresses the novel notion of offering a radio access network as a service. Its components may be instantiated on general purpose platforms with pooled resources (both radio and hardware ones) dimensioned on-demand, elastically and following the pay-per-use principle. A novel architecture

  5. Globalization and Landscape Architecture

    Directory of Open Access Journals (Sweden)

    Robert R. Hewitt

    2014-02-01

    Full Text Available The literature review examines globalization and landscape architecture as discourse, samples its various meanings, and proposes methods to identify and contextualize its specific literature. Methodologically, the review surveys published articles and books by leading authors and within the WorldCat.org Database associated with landscape architecture and globalization, analyzing survey results for comprehensive conceptual and co-relational frameworks. Three “higher order” dimensions frame the review’s conceptual organization, facilitating the organization of subordinate/subtopical areas of interest useful for comparative analysis. Comparative analysis of the literature suggests an uneven clustering of discipline-related subject matter across the literature’s “higher order” dimensions, with a much smaller body of literature related to landscape architecture confined primarily to topics associated with the dispersion of global phenomena. A subcomponent of this smaller body of literature is associated with other fields of study, but inferentially related to landscape architecture. The review offers separate references and bibliographies for globalization literature in general and globalization and landscape architecture literature, specifically.

  6. Development and in vitro assessment of alginate bilayer films containing the olive compound hydroxytyrosol as an alternative for topical chemotherapy.

    Science.gov (United States)

    Ng, Shiow-Fern; Tan, Say-Lee

    2015-11-30

    Topical chemotherapy is the application of cancer drugs directly onto the skin, which has become a standard treatment for basal cell carcinoma. Due to the promising results in the treatment of skin cancer, topical chemotherapy has recently been applied to breast cancer patients because some breast cancer tissues are only superficial. Hydroxytyrosol, a phenolic compound from olives that is present in high amounts in Hidrox(®) olive extract, has been shown to have a protective effect on normal cells and selective antitumor activities on cancerous cells. The aims of the present study were to develop an alginate bilayer film containing Hidrox(®) and to investigate its potential use as a topical chemotherapeutic agent. Alginate films were characterized for swelling and for physical, thermal, rheological, and mechanical properties. Drug content uniformity and in vitro drug release tests were also investigated. The alginate bilayer films containing Hidrox(®), HB2, showed controlled release of hydroxytyrosol at a flux of 0.094±0.009 mg/cm(2)/h. The results of the cytotoxic assay showed that the HB2 films were dose-dependent and could significantly reduce the growth of breast cancer cells (MCF-7) at 150 μg/mL for a cell viability of 29.34±4.64%. In conclusion, an alginate bilayer film containing Hidrox(®) can be a potential alternative for topical chemotherapeutic agent for skin and breast cancer treatment.

  7. Nanoemulsion as a carrier to improve the topical anti-inflammatory activity of stem bark extract of Rapanea ferruginea

    Science.gov (United States)

    Dal Mas, Juarana; Zermiani, Tailyn; Thiesen, Liliani C; Silveira, Joana LM; da Silva, Kathryn ABS; de Souza, Márcia M; Malheiros, Angela; Bresolin, Tania MB; Lucinda-Silva, Ruth M

    2016-01-01

    The aim of this study was to develop nanoemulsion containing soft extract of stem bark of Rapanea ferruginea to improve the topical delivery and anti-inflammatory activity. The extract of R. ferruginea stem bark was incorporated into the oily phase of the nanoemulsion by the method of phase inversion at low energy. The developed nanoemulsion had an average droplet size of 47.88±8.20 nm and a polydispersibility index of 0.228. Uniformity of size, spherical shape of droplet, and absence of clusters were confirmed by transmission electronic microscopy. The zeta potential was −34.7±1.15 mV. The nanoemulsion showed a moderate degree of skin irritation in the agarose overlay assay in vitro. The content of the extract markers, myrsinoic acids A and B, was 54.10±0.08 and 53.03 μg/g in the formulation, respectively. The formulation demonstrated pseudoplastic and thixotropic rheological behavior. In vitro release of chemical markers was controlled by diffusion mechanism. An extract-loaded nanoemulsion showed a topical anti-inflammatory activity in a croton oil-induced edema ear model, with a decrease in tumor necrosis factor release and myeloperoxidase activity. The nanoemulsion was 160% more efficient than the conventional cream containing 0.13% of the extract. The nanoemulsion showed suitable properties as a carrier for topical use of R. ferruginea extract and the approach for improving the topical anti-inflammatory activity. PMID:27660442

  8. EVALUATION OF THE EFFECTIVENESS OF TOPICAL EMLA CREAM AS LOCAL ANAESTHETIC IN VENEPUNCTURE

    Directory of Open Access Journals (Sweden)

    Bodicherla Siva

    2016-05-01

    Full Text Available BACKGROUND AND OBJECTIVES The efficacy of a topical anaesthetic formulation, EMLA 5% cream (Eutectic Mixture of Local Anaesthetics in obtunding the pain produced by intravenous cannulation was determined in our study. This study aims at evaluating the eff icacy of EMLA cream in producing dermal analgesia for venous cannulation and the effect of timing of application of EMLA cream prior to cannulation. MATERIALS AND METHODS Amongst 60 patients, EMLA cream was applied for 60 minutes in 20 patients, 30 minutes in another 20 and in the remaining 20 no cream or placebo was applied. RESULTS Pain was assessed in all the groups by a 4-point rank score. It was found that patients with EMLA cream had lower pain scores and decreased haemodynamic stress response to venous cannulation when compared to the control group. INTERPRETATION AND CONCLUSION Maximum analgesia was observed in patients who had EMLA cream applied for 60 minutes. No significant side effects were seen with this formulation

  9. Effect of topical anti-glaucoma medications on late pupillary light reflex, as evaluated by pupillometry

    DEFF Research Database (Denmark)

    Ba-Ali, Shakoor; Sander, Birgit; Brøndsted, Adam Elias;

    2015-01-01

    PURPOSE: The late post-illumination pupillary response (PIPR 10-30s ) to blue light is reduced in glaucoma, suggesting that pupillometry can be used in clinical glaucoma evaluation. Since animal studies have indicated that common anti-glaucomatous agents affect the iris muscle, we investigated...... the short-term effect of the anti-glaucoma drugs on the pupillary light reflex and in particular on the PIPR10-30s. METHODS: In this randomized, double-masked, crossover trial, pupillometry was performed before and after topical administration of latanoprost, dorzolamide, and timolol in 20 healthy subjects...... reduced by all three drugs after 3.5 h (p glaucoma medications did not interfere with the blue light elicited PIPR. Dorzolamide reduced pupil size, while timolol reduced both pupil size and maximal contraction to red...

  10. Software architecture

    CERN Document Server

    Vogel, Oliver; Chughtai, Arif

    2011-01-01

    As a software architect you work in a wide-ranging and dynamic environment. You have to understand the needs of your customer, design architectures that satisfy both functional and non-functional requirements, and lead development teams in implementing the architecture. And it is an environment that is constantly changing: trends such as cloud computing, service orientation, and model-driven procedures open up new architectural possibilities. This book will help you to develop a holistic architectural awareness and knowledge base that extends beyond concrete methods, techniques, and technologi

  11. Architecture as spatial–textile storytelling: Metamorphosis of frieze as a narrative medium mediating the Panathenaia festival

    Directory of Open Access Journals (Sweden)

    Fangqing Lu

    2016-12-01

    The paper concludes that the significance of the religious Panathenaia festival is not merely depicted by the peplos identified on the central east Ionic frieze, but is also expressed in the entire representational scheme of the Ionic frieze, along with the overall spatial configuration of the Parthenon. Architecture, instantiated by the Parthenon, is regarded as spatial–textile storytelling to communicate meanings.

  12. MCM-41 as a useful vector for rutin topical formulations: synthesis, characterization and testing.

    Science.gov (United States)

    Berlier, Gloria; Gastaldi, Lucia; Sapino, Simona; Miletto, Ivana; Bottinelli, Emanuela; Chirio, Daniela; Ugazio, Elena

    2013-11-30

    Rutin, the glycoside of quercetin, could be used in topical preparations because of its antioxidant and radical scavenging properties, but its employ in cosmetic and pharmaceutical products is limited by poor physico-chemical stability. These issues were addressed by preparing, characterizing and testing rutin inclusion complexes with MCM-41 mesoporous silica. The effect of surface functionalization with aminopropyl groups (NH₂-MCM-41) on the molecules properties was studied. The organic/inorganic interaction was confirmed by many techniques. In particular, the high inclusion of rutin in the pores of NH₂-MCM-41 was assessed by XRD, TGA, gas-volumetric analysis (BET), while FTIR spectroscopy allowed to analyse with great detail the molecular interaction with the inorganic surface. Rutin was stabilized against UV degradation, mostly by its inclusion in NH₂-MCM-41. Ex vivo studies showed a greater accumulation in porcine skin in the case of rutin complexed with NH₂-MCM-41. Not only antioxidant properties of rutin were maintained after immobilization but, with aminopropyl silica, the metal-chelating activity increased noticeably. The immobilization of rutin in aminopropyl silica resulted in better performance in terms of activity and photostability, suggesting the importance of functionalization in stabilizing organic molecules within silica pores.

  13. Lavender-thymol as a new topical aromatherapy preparation for episiotomy: A randomised clinical trial.

    Science.gov (United States)

    Marzouk, T; Barakat, R; Ragab, A; Badria, F; Badawy, A

    2015-01-01

    The objective of this study was to evaluate the effectiveness of topical lavender-thymol in promoting episiotomy healing. This placebo-controlled, single-blinded, randomised clinical trial involved 60 primiparous women. REEDA score was used to evaluate the outcome of the trial. On the 7th post-partum day, women in Placebo-treated group had worse Redness, Edema, Ecchymosis, Discharge and Approximation (REEDA) score of 3.93 ± 3.65 compared with those in Lavender-thymol-treated group (2.03 ± 1.7) with significant difference (P = 0.013). Visual analogue Scale (VAS) score for pain at episiotomy in Lavender-thymol-treated group was 3.5 ± 1.9, whereas in Placebo-treated group it was 2.1 ± 2.2 (p = 0.011) for dyschezia, 3.8 ± 1.7 and 2.8 ± 1.6 in Placebo- and Lavender-thymol-treated women, respectively (p = 0.023). At 7th post-partum week, dyspareunia was more severe in Placebo-treated group compared with that in Lavender-thymol-treated group (5.3 ± 2.7 vs 2.7 ± 1.5 and p episiotomy wound care with little or no expected side effects compared with that using placebo.

  14. Misselling as a New Topic of Financial Education? A Didactic Analysis of Investment Advise after the Financial Crisis

    Directory of Open Access Journals (Sweden)

    Dirk Loerwald

    2010-07-01

    Full Text Available Personal financial investments are, as a matter of course, a topic of economic education because they are a life situation which is inherently economical. In contrast, faulty advising in banks which has become focussed upon due to the extent it has played a part in the recent financial crisis is mentioned neither in curricula nor in educational text books. Numerous private funds have been exposed as unprofitable investments. One reason for this problem is to be found in the marketing staff of the banks who did not invest their customer’s funds securely enough – and the customers did not notice it. What conclusions can be drawn from this for general financial education after the financial crisis? The economic education has failed to address the topic of “faulty advising in banks” as well. On the basis of categorical economic didactics the following contribution will analyse whether one has an exemplary case here upon which students can win generalized, transferable insights. In this context, the topic of personal financial investments will be classified in an efficient manner and the risk of opportunism in advising situations will be analysed with the help of the positive principal-agent theory. The results of this analysis of informational asymmetries within financial markets give direction to the development and revision of curricula in the didactics of economic education. With the following article a sustainable theoretical fundament will be created to underscore the obligatory inclusion of this topic in curricula as well as its realisation for target groups in school text books.

  15. Clindamycin Topical

    Science.gov (United States)

    ... topical clindamycin.you should know that abrasive or medicated soaps and skin products that contain alcohol may ... in, tightly closed, and out of reach of children. Store it at room temperature and away from ...

  16. Tretinoin Topical

    Science.gov (United States)

    ... lotions, astringents, and perfumes); they can sting your skin, especially when you first use tretinoin.Do not use any other topical medications, especially benzoyl peroxide, salicylic acid (wart remover), and dandruff shampoos containing sulfur or ...

  17. Syntacticized topics in Kurmuk

    DEFF Research Database (Denmark)

    Andersen, Torben

    2015-01-01

    This article argues that Kurmuk, a little-described Western Nilotic language, is characterized by a syntacticized topic whose grammatical relation is variable. In this language, declarative clauses have as topic an obligatory preverbal NP which is either a subject, an object or an adjunct....... The grammatical relation of the topic is expressed by a voice-like inflection of the verb, here called orientation. While subject-orientation is morphologically unmarked, object-oriented and adjunct-oriented verbs are marked by a subject suffix or by a suffix indicating that the topic is not subject, and adjunct......-orientation differs from object-orientation by a marked tone pattern. Topic choice largely reflects information structure by indicating topic continuity. The topic also plays a crucial role in relative clauses and in clauses with contrastive constituent focus, in that objects and adjuncts can only be relativized...

  18. Infill architecture: Design approaches for in-between buildings and 'bond' as integrative element

    Directory of Open Access Journals (Sweden)

    Alfirević Đorđe

    2015-01-01

    Full Text Available The aim of the paper is to draw attention to the view that the two key elements in achieving good quality of architecture infill in immediate, current surroundings, are the selection of optimal creative method of infill architecture and adequate application of 'the bond' as integrative element, The success of achievement and the quality of architectural infill mainly depend on the assessment of various circumstances, but also on the professionalism, creativity, sensibility, and finally innovativeness of the architect, In order for the infill procedure to be carried out adequately, it is necessary to carry out the assessment of quality of the current surroundings that the object will be integrated into, and then to choose the creative approach that will allow the object to establish an optimal dialogue with its surroundings, On a wider scale, both theory and the practice differentiate thee main creative approaches to infill objects: amimetic approach (mimesis, bassociative approach and ccontrasting approach, Which of the stated approaches will be chosen depends primarily on the fact whether the existing physical structure into which the object is being infilled is 'distinct', 'specific' or 'indistinct', but it also depends on the inclination of the designer, 'The bond' is a term which in architecture denotes an element or zone of one object, but in some instances it can refer to the whole object which has been articulated in a specific way, with an aim of reaching the solution for the visual conflict as is often the case in situations when there is a clash between the existing objects and the newly designed or reconstructed object, This paper provides in-depth analysis of different types of bonds, such as 'direction as bond', 'cornice as bond', 'structure as bond', 'texture as bond' and 'material as bond', which indicate complexity and multiple layers of the designing process of object interpolation.

  19. Double-layer-gate architecture for few-hole GaAs quantum dots

    Science.gov (United States)

    Wang, D. Q.; Hamilton, A. R.; Farrer, I.; Ritchie, D. A.; Klochan, O.

    2016-08-01

    We report the fabrication of single and double hole quantum dots using a double-layer-gate design on an undoped accumulation mode {{Al}}x{{Ga}}1-x{As}/GaAs heterostructure. Electrical transport measurements of a single quantum dot show varying addition energies and clear excited states. In addition, the two-level-gate architecture can also be configured into a double quantum dot with tunable inter-dot coupling.

  20. Safety, efficacy, and patient acceptability of lidocaine hydrochloride ophthalmic gel as a topical ocular anesthetic for use in ophthalmic procedures

    Directory of Open Access Journals (Sweden)

    Michael A Page

    2009-10-01

    Full Text Available Michael A Page, Frederick W FraunfelderDepartment of Ophthalmology (Casey Eye Institute, Oregon Health and Science University, Portland, OR, USAPurpose: To review the current literature on safety, efficacy, and measures of surgeon and patient satisfaction with lidocaine hydrochloride gel as a tool for ocular anesthesia.Methods: Pubmed search using keywords “lidocaine gel,” “ophthalmic,” and “surgery” and compiling cross-references. Twenty-six total references were reviewed, including 15 prospective randomized controlled trials (RCTs, total N = 933, average N = 62, 6 nonrandomized prospective studies (total N = 234, average N = 39, 2 animal studies, 1 microbiologic study, and 2 letters to the editor.Results: The RCTs and nonrandomized prospective studies evaluated a number of measures including timing of onset of anesthesia, duration of anesthesia, intraoperative and postoperative pain, need for additional anesthetic applications, intracameral lidocaine levels, and adverse effects. Control groups received topical drops, subconjunctival anesthetic, retrobulbar anesthetic, or sham gel. Lidocaine gel was shown to be at least as effective for pain control as alternative therapies in all studies, with longer duration of action than topical drops. Patient and surgeon satisfaction were high, and adverse effects were rare and comparable to those for anesthetic drop formulations. Surgical settings included cataract, pterygium, trabeculectomy, strabismus, intravitreal injection, vitrectomy, and penetrating keratoplasty.Conclusions: Lidocaine gel is a safe, effective, and potentially underutilized tool for ophthalmic surgery.Keywords: lidocaine, gel, topical, ophthalmic, ocular, anesthetic

  1. Islamic Architecture as a Field of Historical Enquiry, AD Architectural Design, 74(6, 2004 Reproduced by courtesy of the publishers John Wiley & Sons Ltd.

    Directory of Open Access Journals (Sweden)

    Nasser Rabbat

    2012-12-01

    Full Text Available Islamic architecture, a young field with a conservative scholarly lineage, has only recently begun to find its own theoretical bearings. After briefly reviewing the origins and formative stages of the field in the West, this article identifies a turning point brought about by the publication of Edward Saïd's seminal book Orientalism in 1978. It then introduces three critical notions, dynamic periodization, multiculturalism, and dialogue, which offer a framework for the study of Islamic architecture as a tradition with a solid historical selfconsciousness.

  2. Oak leaf extract as topical antioxidant: free radical scavenging and iron chelating activities and in vivo skin irritation potential.

    Science.gov (United States)

    Almeida, Isabel F; Valentão, Patrícia; Andrade, Paula B; Seabra, Rosa M; Pereira, Teresa M; Amaral, M Helena; Costa, Paulo C; Bahia, M Fernanda

    2008-01-01

    The topical application of antioxidants may be beneficial for the protection of the skin against UV damage. An extract of Quercus robur leaves was prepared and evaluated considering its putative application as topical antioxidant. The solvent and extractive method selection was monitored by 1,1-diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging activity and polyphenols extraction (measured by the Folin Ciocalteu assay). Iron chelating activity and the phenolic composition (HPLC/DAD) were assessed on the extract obtained under optimized conditions. Skin irritation potential was investigated by performing an in vivo patch test in 19 volunteers. The extraction solvent which resulted in the highest activity was ethanol:water (4:6) and thus it was selected for further preparation of this extract. The IC50s for the iron chelation and DPPH scavenging assays were 153.8 +/- 26.3 microg x mL-1 and 7.53 +/- 0.71 microg x mL-1 (mean +/- SD), respectively. The total phenolic content was found to be 346.3 +/- 6.7 mg gallic acid equivalents (GAE)/g extract (mean +/- SD). Three phenolic compounds were identified in the extract namely: ellagic acid, rutin and hyperoside. The major identified component was ellagic acid. The patch test carried out showed that the extract can be regarded as safe for topical application.

  3. Hijazi Architectural Object Library (haol)

    Science.gov (United States)

    Baik, A.; Boehm, J.

    2017-02-01

    As with many historical buildings around the world, building façades are of special interest; moreover, the details of such windows, stonework, and ornaments give each historic building its individual character. Each object of these buildings must be classified in an architectural object library. Recently, a number of researches have been focusing on this topic in Europe and Canada. From this standpoint, the Hijazi Architectural Objects Library (HAOL) has reproduced Hijazi elements as 3D computer models, which are modelled using a Revit Family (RFA). The HAOL will be dependent on the image survey and point cloud data. The Hijazi Object such as Roshan and Mashrabiyah, become as vocabulary of many Islamic cities in the Hijazi region such as Jeddah in Saudi Arabia, and even for a number of Islamic historic cities such as Istanbul and Cairo. These architectural vocabularies are the main cause of the beauty of these heritage. However, there is a big gap in both the Islamic architectural library and the Hijazi architectural library to provide these unique elements. Besides, both Islamic and Hijazi architecture contains a huge amount of information which has not yet been digitally classified according to period and styles. Due to this issue, this paper will be focusing on developing of Heritage BIM (HBIM) standards and the HAOL library to reduce the cost and the delivering time for heritage and new projects that involve in Hijazi architectural styles. Through this paper, the fundamentals of Hijazi architecture informatics will be provided via developing framework for HBIM models and standards. This framework will provide schema and critical information, for example, classifying the different shapes, models, and forms of structure, construction, and ornamentation of Hijazi architecture in order to digitalize parametric building identity.

  4. Local architecture

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Local architecture refers to structures built in the countryside,such as temples,memorial halls,residences, stores,pavilions, bridges,decorated archways, and wells. Because these structures were all built by focal craftsmen and villagers in the traditional local style, they are generally called local architecture.

  5. Architectural Contestation

    NARCIS (Netherlands)

    Merle, J.

    2012-01-01

    This dissertation addresses the reductive reading of Georges Bataille's work done within the field of architectural criticism and theory which tends to set aside the fundamental ‘broken’ totality of Bataille's oeuvre and also to narrowly interpret it as a mere critique of architectural form, consequ

  6. Architecture Governance: The Importance of Architecture Governance for Achieving Operationally Responsive Ground Systems

    Science.gov (United States)

    Kolar, Mike; Estefan, Jeff; Giovannoni, Brian; Barkley, Erik

    2011-01-01

    Topics covered (1) Why Governance and Why Now? (2) Characteristics of Architecture Governance (3) Strategic Elements (3a) Architectural Principles (3b) Architecture Board (3c) Architecture Compliance (4) Architecture Governance Infusion Process. Governance is concerned with decision making (i.e., setting directions, establishing standards and principles, and prioritizing investments). Architecture governance is the practice and orientation by which enterprise architectures and other architectures are managed and controlled at an enterprise-wide level

  7. A Summary of Information on the Behavior of the Yakima Fold Belt as a Structural Entity -- Topical Report

    Energy Technology Data Exchange (ETDEWEB)

    Last, George V.; Winsor, Kelsey; Unwin, Stephen D.

    2012-08-01

    This document is one in a series of topical reports compiled by the Pacific Northwest National Laboratory to summarize technical information on selected topics important to the performance of a probabilistic seismic hazard analysis (PSHA) of the Hanford Site. The purpose of this report is to summarize available data and analyses relevant to the Yakima Fold Belt (YFB) that may bear on the question of whether or not the YFB behaves as a single seismotectonic province in which activity along one fold structure is representative of behavior along all other fold structures. This topic has met with a fairly high level of contention in the expert community and has the potential to result in significant impacts on an evaluation of seismic hazard at the Hanford Site. This report defines the relevant alternative conceptual models relevant to this technical issue and the arguments and data that support those models. It provides a brief description of the technical issue and principal uncertainties; a general overview on the nature of the technical issue, along with alternative conceptual models, supporting arguments and information, and uncertainties; and finally, it suggests some possible approaches for reducing uncertainties regarding this issue.

  8. Choice architecture as a means to change eating behaviour in self-service settings

    DEFF Research Database (Denmark)

    Skov, Laurits Rohden; Lourenco, Sofia; Laub Hansen, Gitte

    2013-01-01

    food choice, whilst (ii) manipulating the plate and cutlery size has an inconclusive effect on consumption volume. Finally, (iii) assortment manipulation and (iv) payment option manipulation was associated with healthier food choices. The majority of studies were of very weak quality and future......Summary: The primary objective of this review was to investigate the current evidence-base for the use of choice architecture as a means to change eating behaviour in self-service eating settings, hence potentially reduce calorie intake. 12 databases were searched systematically for experimental...... studies with predefined choice architectural interventions in the period June 2011 – March 2012. The 12 included studies were grouped according to type of interventions and underwent a narrative synthesis. The evidence indicates that (i) health labelling at point-of-purchase is associated with healthier...

  9. Evaluation Research as a Mechanism for Critical Inquiry and Knowledge Construction in Architectural and Urban Education

    Directory of Open Access Journals (Sweden)

    Ashraf M. Salama

    2012-12-01

    Full Text Available This article responds to the misconceptions that continue to characterize the delivery of knowledge content in architectural courses. Based on reviewing the literature on pedagogy the paper explores the value and benefits of introducing evaluation research as a mechanism for critical inquiry and knowledge construction in theory courses in architecture and urbanism. A framework is developed and employed to demonstrate the way in which this type of learning can be incorporated.   The development and implementation of a series of in-class and off campus exercises in two different contexts reveal that structured actions and experiences help students to be in control over their learning while invigorating their understanding of the body of knowledge delivered in a typical lecture format. It firmly believed that this would offer students multiple learning opportunities while fostering their capabilities to shift from passive listeners to active learners and from knowledge consumers to knowledge producers.

  10. Architectural Theatricality

    DEFF Research Database (Denmark)

    Tvedebrink, Tenna Doktor Olsen

    and well-being, as well as outline a set of basic design principles ‘predicting’ the future interior architectural qualities of patient eating environments. Methodologically the thesis is based on an explorative study employing an abductive approach and hermeneutic-interpretative strategy utilizing tactics......This PhD thesis is motived by a personal interest in the theoretical, practical and creative qualities of architecture. But also a wonder and curiosity about the cultural and social relations architecture represents through its occupation with both the sciences and the arts. Inspired by present...... initiatives in Aalborg Hospital to overcome patient undernutrition by refurbishing eating environments, this thesis engages in an investigation of the interior architectural qualities of patient eating environments. The relevance for this holistic perspective, synthesizing health, food and architecture...

  11. [Topical therapy of rosacea].

    Science.gov (United States)

    Schöfer, H

    2013-07-01

    Metronidazole and azelaic acid are the only topical medications approved for rosacea. All other topical treatments for rosacea and its special forms are used off-label. Topical steroids are not indicated in rosacea, because of their side effects (induction of steroid rosacea, high risk of facial skin atrophy, and high risk of rebound after cessation of therapy). Topical as well as systemic steroids are allowed only as initial and short term therapy for acute forms of rosacea (e.g. rosacea fulminans). Papular and pustular rosacea is the major indication for topical therapy. Sebaceous gland and connective tissue hyperplasia in glandular-hypertrophic rosacea as well as erythema in erythematous rosacea do not respond well to topical measures. A new active substance, the alpha-2-adrenoreceptor agonist brimonidine, will be approved soon for the topical treatment of erythema in rosacea. All severe forms of rosacea should initially be treated with a combination of topical and systemic agents. After improvement of the clinical symptoms, topical treatment alone is usually adequate to maintain the control.

  12. Architectural Narratives

    DEFF Research Database (Denmark)

    Kiib, Hans

    2010-01-01

    and architectural heritage; another group tries to embed new performative technologies in expressive architectural representation. Finally, this essay provides a theoretical framework for the analysis of the political rationales of these projects and for the architectural representation bridges the gap between......In this essay, I focus on the combination of programs and the architecture of cultural projects that have emerged within the last few years. These projects are characterized as “hybrid cultural projects,” because they intend to combine experience with entertainment, play, and learning. This essay...... identifies new rationales related to this development, and it argues that “cultural planning” has increasingly shifted its focus from a cultural institutional approach to a more market-oriented strategy that integrates art and business. The role of architecture has changed, too. It not only provides...

  13. The Concept of the Interculture in Time: (Inter)cultural Topics in Textbooks of French as a Foreign Language

    OpenAIRE

    2012-01-01

    The article deals with the concept of interculturality as used in foreign language didactics. In accordance with the definition of interculturality given in the first part of the article, two categories are included in the analysis – two “levels” of culture, each of them bearing a different name in literature, namely high and popular culture. Various textbooks used for teaching French as a foreign language in Slovenia in both the past and present were chosen for the analysis of topics that co...

  14. Software architecture 2

    CERN Document Server

    Oussalah, Mourad Chabanne

    2014-01-01

    Over the past 20 years, software architectures have significantly contributed to the development of complex and distributed systems. Nowadays, it is recognized that one of the critical problems in the design and development of any complex software system is its architecture, i.e. the organization of its architectural elements. Software Architecture presents the software architecture paradigms based on objects, components, services and models, as well as the various architectural techniques and methods, the analysis of architectural qualities, models of representation of architectural templa

  15. Software architecture 1

    CERN Document Server

    Oussalah , Mourad Chabane

    2014-01-01

    Over the past 20 years, software architectures have significantly contributed to the development of complex and distributed systems. Nowadays, it is recognized that one of the critical problems in the design and development of any complex software system is its architecture, i.e. the organization of its architectural elements. Software Architecture presents the software architecture paradigms based on objects, components, services and models, as well as the various architectural techniques and methods, the analysis of architectural qualities, models of representation of architectural template

  16. Humanizing Architecture

    DEFF Research Database (Denmark)

    Toft, Tanya Søndergaard

    2015-01-01

    The article proposes the urban digital gallery as an opportunity to explore the relationship between ‘human’ and ‘technology,’ through the programming of media architecture. It takes a curatorial perspective when proposing an ontological shift from considering media facades as visual spectacles...... agency and a sense of being by way of dematerializing architecture. This is achieved by way of programming the symbolic to provide new emotional realizations and situations of enlightenment in the public audience. This reflects a greater potential to humanize the digital in media architecture....

  17. Absorption of Bupivacaine after Administration of a Lozenge as Topical Treatment for Pain from Oral Mucositis

    DEFF Research Database (Denmark)

    Mogensen, Stine; Sverrisdóttir, Eva; Sveinsdóttir, Kolbrún;

    2017-01-01

    , respectively, after administration. The plasma concentration-time profiles of bupivacaine were fitted to pharmacokinetic models using nonlinear mixed-effects modelling, evaluating demographics and health status as covariates. The population pharmacokinetics (PK) of bupivacaine lozenge was best described...

  18. Kinetic Digitally-Driven Architectural Structures as ‘Marginal’ Objects – a Conceptual Framework

    Directory of Open Access Journals (Sweden)

    Sokratis Yiannoudes

    2014-07-01

    Full Text Available Although the most important reasons for designing digitally-driven kinetic architectural structures seem to be practical ones, namely functional flexibility and adaptation to changing conditions and needs, this paper argues that there is possibly an additional socio-cultural aspect driving their design and construction. Through this argument, the paper attempts to debate their status and question their concepts and practices.Looking at the design explorations and discourses of real or visionary technologically-augmented architecture since the 1960s, one cannot fail to notice the use of biological metaphors and concepts to describe them – an attempt to ‘naturalise’ them which culminates today in the conception of kinetic structures and intelligent environments as literally ‘alive’. Examining these attitudes in contemporary examples, the paper demonstrates that digitally-driven kinetic structures can be conceived as artificial ‘living’ machines that undermine the boundary between the natural and the artificial. It argues that by ‘humanising’ these structures, attributing biological characteristics such as self-initiated motion, intelligence and reactivity, their designers are ‘trying’ to subvert and blur the human-machine (-architecture discontinuity.The argument is developed by building a conceptual framework which is based on evidence from the social studies of science and technology, in particular their critique in modern nature-culture and human-machine distinctions, as well as the history and theory of artificial life which discuss the cultural significance and sociology of ‘living’ objects. In particular, the paper looks into the techno-scientific discourses and practices which, since the 18th century, have been exploring the creation of ‘marginal’ objects, i.e. seemingly alive objects made to challenge the nature-artifice boundary.

  19. Evaluation of a polyherbal topical aerosol spray as a supportive therapy for clinical mastitis in dairy cows

    Directory of Open Access Journals (Sweden)

    Ramasamy Selvam

    2015-09-01

    Full Text Available The present study was designed to evaluate the polyherbal topical aerosol spray Wisprec and reg; Advanced (M/S. Natural Remedies Private Limited, India as a supportive therapy for clinical mastitis in dairy cows. A total of 41 dairy cows suffering from clinical mastitis were selected, and Wisprec and reg; Advanced was sprayed on mastitis affected quarters of udder two times a day along with a parenteral antibiotic till complete recovery. The rectal temperature, pain on palpation of udder, swelling of udder, consistency of milk, recovery period and product satisfaction score were assessed to evaluate the efficacy of Wisprec and reg; Spray. Topical application of Wisprec and reg; Advanced Spray have shown a significant improvement (p<0.001 in alleviation of rectal temperature, pain on palpation of udder and swelling of udder, and the consistency of milk was restored to normal after 3 to 4 days of treatment. The results demonstrate that the Wisprec and reg; Advanced spray could be considered as an alternative to non-steroidal anti-inflammatory drugs (NSAIDs as a supportive therapy for clinical mastitis of dairy cows. [J Adv Vet Anim Res 2015; 2(3.000: 285-290

  20. Balancing Constraints and the Sweet Spot as Coming Topics for Creativity Research

    DEFF Research Database (Denmark)

    Onarheim, Balder; Biskjaer, Michael Mose

    2015-01-01

    and creativity, with skillful and innovative handling of constraints seen as a prerequisite for apt creative performance. Based on a brief review of current disparate conceptualizations of constraints as both enablers and restrainers of creative activities, we begin by proposing the unifying concept ‘creativity......The aim of this chapter is the introduction of two new concepts, ‘balancing constraints’ and ‘the sweet spot of creativity’, as promising new paths for creativity research. This is motivated by the fact that creativity research shows a growing interest in the fundamental entwinement of constraints...... constraints’ to help establish common terminological ground. Since the presence of constraints change over time, we suggest the term ‘constrainedness’ to articulate this total constraint intensity at a given time. This allows us to introduce our main contribution, the concept ‘the sweet spot’, to address...

  1. Balancing Constraints and the Sweet Spot as Coming Topics for Creativity Research

    DEFF Research Database (Denmark)

    Onarheim, Balder; Biskjaer, Michael Mose

    2016-01-01

    and creativity, with skillful and innovative handling of constraints seen as a prerequisite for apt creative performance. Based on a brief review of current disparate conceptualizations of constraints as both enablers and restrainers of creative activities, we begin by proposing the unifying concept ‘creativity......The aim of this chapter is the introduction of two new concepts, ‘balancing constraints’ and ‘the sweet spot of creativity’, as promising new paths for creativity research. This is motivated by the fact that creativity research shows a growing interest in the fundamental entwinement of constraints...... constraints’ to help establish common terminological ground. Since the presence of constraints change over time, we suggest the term ‘constrainedness’ to articulate this total constraint intensity at a given time. This allows us to introduce our main contribution, the concept ‘the sweet spot’, to address...

  2. Advances in studies of phospholipids as carriers in skin topical application

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective:This article provides an overview of characteristics of phospholipids,the characteristics and influential factors of liposome and microemulsion as carriers for skin delivery of drugs,and the latest advances of the phospholipids carriers in transdermal delivery systems.The perspective is that phospholipids carriers may be capable of a wide range of applications in the transdermal defivery system.

  3. New lidocaine lozenge as topical anesthesia compared to lidocaine viscous oral solution before upper gastrointestinal endoscopy

    DEFF Research Database (Denmark)

    Mogensen, Stine; Treldal, Charlotte; Feldager, Erik

    2012-01-01

    To evaluate the effect and acceptance of a new lidocaine lozenge compared with a lidocaine viscous oral solution as a pharyngeal anesthetic before upper gastrointestinal endoscopy (UGE), a diagnostic procedure commonly performed worldwide during which many patients experience severe discomfort mo...

  4. Absorption of Bupivacaine after Administration of a Lozenge as Topical Treatment for Pain from Oral Mucositis.

    Science.gov (United States)

    Mogensen, Stine; Sverrisdóttir, Eva; Sveinsdóttir, Kolbrún; Treldal, Charlotte; Jensen, Kenneth; Jensen, Anders Bonde; Kristensen, Claus Andrup; Jacobsen, Jette; Kreilgaard, Mads; Petersen, Janne; Andersen, Ove

    2017-01-01

    The aim was to investigate systemic exposure after administration of a novel bupivacaine lozenge in healthy individuals with normal mucosa and in head and neck cancer (HNC) patients with oral mucositis. A lozenge containing 5, 10, 25 and 50 mg bupivacaine, respectively, was administered as single dose to 10 healthy individuals, and a lozenge containing 25 mg bupivacaine was administered as single dose to 10 HNC patients with oral mucositis and as multiple doses to five patients with HNC. Blood samples were collected for 6 hr from the healthy individuals and 3 hr from the patients with HNC, respectively, after administration. The plasma concentration-time profiles of bupivacaine were fitted to pharmacokinetic models using nonlinear mixed-effects modelling, evaluating demographics and health status as covariates. The population pharmacokinetics (PK) of bupivacaine lozenge was best described by a two-compartment distribution model with absorption transit compartments. All the observed plasma concentrations were well below the bupivacaine concentrations (2000-2250 ng/ml) which have caused toxic symptoms. The PK model suggested that relative bioavailability was two times higher in HNC patients with oral mucositis grade 1-2 and three times higher in HNC patients with oral mucositis grade 3-4 than in the healthy individuals. Simulations showed that the plasma concentrations would be below the toxic limit after repeated dosing every second hour with 25 mg bupivacaine for five days. The 25-mg bupivacaine lozenges were safe without systemic toxic levels of bupivacaine or risk of side effects. Based on PK simulations of repeated doses of 25 mg every two hours for 16 hr a day, the lozenges can be administered with minimum risk of exceeding the toxic limit.

  5. Time as a Key Topic in Health Professionals’ Perceptions of Clinical Handovers

    OpenAIRE

    Bernadette M. Watson; Liz Jones; Julia Cretchley

    2014-01-01

    Clinical handovers are an essential part of the daily care and treatment of hospital patients. We invoked a language and social psychology lens to investigate how different health professional groups discussed the communication problems and strengths they experienced in handovers. We conducted in-depth interviews with three different health professional groups within a large metropolitan hospital. We used Leximancer text analytics software as a tool to analyze the data. Results showed that ti...

  6. Nanoemulsion as a carrier to improve the topical anti-inflammatory activity of stem bark extract of Rapanea ferruginea

    Directory of Open Access Journals (Sweden)

    Dal Mas J

    2016-09-01

    Full Text Available Juarana Dal Mas,1 Tailyn Zermiani,1 Liliani C Thiesen,1 Joana LM Silveira,2 Kathryn ABS da Silva,1 Márcia M de Souza,1 Angela Malheiros,1 Tania MB Bresolin,1 Ruth M Lucinda-Silva1 1NIQFAR, Graduate Program in Pharmaceutical Sciences, University of Vale do Itajaí, Itajaí, Santa Catarina, Brazil; 2Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, Paraná, Brazil Abstract: The aim of this study was to develop nanoemulsion containing soft extract of stem bark of Rapanea ferruginea to improve the topical delivery and anti-inflammatory activity. The extract of R. ferruginea stem bark was incorporated into the oily phase of the nanoemulsion by the method of phase inversion at low energy. The developed nanoemulsion had an average droplet size of 47.88±8.20 nm and a polydispersibility index of 0.228. Uniformity of size, spherical shape of droplet, and absence of clusters were confirmed by transmission electronic microscopy. The zeta potential was -34.7±1.15 mV. The nanoemulsion showed a moderate degree of skin irritation in the agarose overlay assay in vitro. The content of the extract markers, myrsinoic acids A and B, was 54.10±0.08 and 53.03 µg/g in the formulation, respectively. The formulation demonstrated pseudoplastic and thixotropic rheological behavior. In vitro release of chemical markers was controlled by diffusion mechanism. An extract-loaded nanoemulsion showed a topical anti-inflammatory activity in a croton oil-induced edema ear model, with a decrease in tumor necrosis factor release and myeloperoxidase activity. The nanoemulsion was 160% more efficient than the conventional cream containing 0.13% of the extract. The nanoemulsion showed suitable properties as a carrier for topical use of R. ferruginea extract and the approach for improving the topical anti-inflammatory activity. Keywords: nanotechnology, nanoemulsion, Rapanea ferruginea, anti-inflammatory, phytomedicine

  7. HII mesophase as a drug delivery system for topical application of methyl salicylate.

    Science.gov (United States)

    Liang, Xin; Chen, Yu-Lin; Jiang, Xiao-Jing; Wang, Sheng-Mei; Zhang, Ji-Wen; Gui, Shuang-Ying

    2017-03-30

    The main objective of this study was to develop reversed hexagonal (HII) mesophase for transdermal delivery of methyl salicylate. The formulation was prepared, characterized and evaluated for its skin penetration in vitro and skin retention in vivo. Preliminary pharmacodynamics and skin irritation were also investigated. The formulation was identified as hexagonal structure. In vitro study exhibited that HII mesophase enhanced the skin permeation by delivering 2.61 times more methyl salicylate than the commercially available cream. Meanwhile, HII mesophase presented higher bioavailability as AUC(0-24) and AUC(0-∞) were 32.894μg·mL(-1) and 32.935μg·mL(-1) respectively, while the cream were 12.791μg·mL(-1) and 12.970μg·mL(-1). Preliminary pharmacodynamics studies demonstrated that HII mesophase possessed anti-inflammatory and analgesic effects for inhibiting paw edema, granuloma and pain. MeSa HII mesophase showed no skin irritation on the normal rat skin. Thus, HII mesophase was considered as an effective delivery system for MeSa.

  8. Formalin (0.25% as topical anti-microbial agent in burns.

    Directory of Open Access Journals (Sweden)

    Nair R

    1991-01-01

    Full Text Available In a prospective controlled trial, 0.25% formalin spray was compared with 2% silver sulfadiazine cream as the local treatment of burns. Formation and separation of eschar, infection and death rates were recorded. In the group receiving formalin, rates of formation and separation of eschar were significantly more (P less than 0.001 and P less than 0.05 resp. compared to other group. Infection rate and fatality due to infection were also reduced. Other advantages of formalin are ease of application and the low east.

  9. Topical report on sources and systems for aquatic plant biomass as an energy resource

    Energy Technology Data Exchange (ETDEWEB)

    Goldman, J.C.; Ryther, J.H.; Waaland, R.; Wilson, E.H.

    1977-10-21

    Background information is documented on the mass cultivation of aquatic plants and systems design that is available from the literature and through consultation with active research scientists and engineers. The biology of microalgae, macroalgae, and aquatic angiosperms is discussed in terms of morphology, life history, mode of existence, and ecological significance, as they relate to cultivation. The requirements for growth of these plants, which are outlined in the test, suggest that productivity rates are dependent primarily on the availability of light and nutrients. It is concluded that the systems should be run with an excess of nutrients and with light as the limiting factor. A historical review of the mass cultivation of aquatic plants describes the techniques used in commercial large-scale operations throughout the world and recent small-scale research efforts. This review presents information on the biomass yields that have been attained to date in various geographical locations with different plant species and culture conditions, emphasizing the contrast between high yields in small-scale operations and lower yields in large-scale operations.

  10. Rubus rosaefolius extract as a natural preservative candidate in topical formulations.

    Science.gov (United States)

    Ostrosky, Elissa Arantes; Marcondes, Elda Maria Cecilio; Nishikawa, Suzana de Oliveira; Lopes, Patricia Santos; Varca, Gustavo Henrique Costa; Pinto, Terezinha de Jesus Andreoli; Consiglieri, T Vladi Olga; Baby, Andre Rolim; Velasco, Maria Valéria Robles; Kaneko, Telma Mary

    2011-06-01

    Even though the synthetic preservatives may offer a high antimicrobial efficacy, they are commonly related to adverse reactions and regarded as having potentially harmful effects caused by chronic consumption. The development of natural preservatives provides a way of reducing the amount of synthetic preservatives normally used in pharmaceutical and cosmetic preparations. In addition, these agents have less toxic effects and represent a possible natural and safer alternative of the preservatives. The purpose of this research was to evaluate the Rubus rosaefolius Smith extract efficiency as a natural preservative in base formulations. Of the extract, 0.2% (w/w) was assayed for its effectiveness of antimicrobial protection in two different base formulations (emulsion and gel). The microbial challenge test was performed following the standard procedures proposed by The United States Pharmacopoeia 33nd, European Pharmacopoeia 6th, Japanese Pharmacopoeia 15th, and the Cosmetics, Toiletries, and Fragrance Association using standardized microorganisms. The results demonstrated that R. rosaefolius extract at the studied concentration reduced the bacterial inocula, satisfying the criterion in all formulations, even though it was not able to present an effective preservative behavior against fungi. Thus, the investigation of new natural substances with preservative properties that could be applied in pharmaceutical and cosmetic products is relevant due to the possibility of substituting or decreasing the concentration of synthetic preservatives, providing a way for the development of safer formulas for the use of consumers.

  11. Studies on rheology and microbiological evaluation of hydrotropically gelled starch as topical vehicle for terbinafine hydrochloride

    Directory of Open Access Journals (Sweden)

    Rao Kovur

    2008-01-01

    Full Text Available The present study was aimed for the development and evaluation of hydrotropic starch gels of terbinafine hydrochloride which is an allylamine derivative of antifungal agent was formulated by using corn starch and sodium salicylate as hydrotropic salt. The gels were prepared in presence and absence of propylene glycol. The prepared gels were evaluated for in vitro drug release, rheological behavior and microbial studies. The degree of increase in the drug diffusion was found to be in order corn starch gel with propylene glycol was greater than corn starch gel without propylene glycol. The microbial studies were carried out in soya bean casein digest medium with Candida albicans as test organisms and were found to be 22.86 ± 0.58 and 20.22 ± 0.65 mm for TCSG (IV and TCS (III, respectively. All the gels exhibited shear thinning. The rheogram indicated that the gel systems are pseudoplastic and exhibited thixotropy. The added propylene glycol has not appreciably altered the apparent viscosity values.

  12. Time as a Key Topic in Health Professionals’ Perceptions of Clinical Handovers

    Directory of Open Access Journals (Sweden)

    Bernadette M. Watson

    2014-10-01

    Full Text Available Clinical handovers are an essential part of the daily care and treatment of hospital patients. We invoked a language and social psychology lens to investigate how different health professional groups discussed the communication problems and strengths they experienced in handovers. We conducted in-depth interviews with three different health professional groups within a large metropolitan hospital. We used Leximancer text analytics software as a tool to analyze the data. Results showed that time was of concern to all groups in both similar and diverse ways. All professionals discussed time management, time pressures, and the difficulties of coordinating different handovers. Each professional group had its own unique perceptions and priorities about handovers. Our findings indicated that health professionals understood what was required for handover improvement but did not have the extra capacity to alter their current environment. Hospital management, with clinicians, need to implement handover schedule processes that prioritize interprofessional representation.

  13. Propylene glycol liposomes as a topical delivery system for miconazole nitrate: comparison with conventional liposomes.

    Science.gov (United States)

    Elmoslemany, Riham M; Abdallah, Ossama Y; El-Khordagui, Labiba K; Khalafallah, Nawal M

    2012-06-01

    Propylene glycol (PG)-phospholipid vesicles have been advocated as flexible lipid vesicles for enhanced skin delivery of drugs. To further characterize the performance of these vesicles and to address some relevant pharmaceutical issues, miconazole nitrate(MN)-loaded PG nanoliposomes were prepared and characterized for vesicle size, entrapment efficiency, in vitro release, and vesicle stability. An issue of pharmaceutical importance is the time-dependent, dilution-driven diffusion of propylene glycol out of the vesicles. This was addressed by assessing propylene glycol using gas chromatography in the separated vesicles and monitoring its buildup in the medium after repeated dispersion of separated vesicles in fresh medium. Further, the antifungal activity of liposomal formulations under study was assessed using Candida albicans, and their in vitro skin permeation and retention were studied using human skin. At all instances, blank and drug-loaded conventional liposomes were included for comparison. The results provided evidence of controlled MN delivery, constant percent PG uptake in the vesicles (≈45.5%) in the PG concentration range 2.5 to 10%, improved vesicle stability, and enhanced skin deposition of MN with minimum skin permeation. These are key issues for different formulation and performance aspects of propylene glycol-phospholipid vesicles.

  14. Ethosomes and liposomes as topical vehicles for azelaic acid: a preformulation study.

    Science.gov (United States)

    Esposito, Elisabetta; Menegatti, Enea; Cortesi, Rita

    2004-01-01

    The basic properties and the in vitro release rate kinetics of azelaic acid (AA), alternatively vehiculated in different phospholipid-based vesicles such as ethosomes or liposomes, were investigated. Ethosomes were produced by a simple method based on addition of an aqueous phase to an ethanol solution (comprised between 20\\% and 45%, v/v) of soy phosphatidyl choline (5%, w/w) and AA (0.2%, w/w) under mechanical stirring. Liposomes were obtained by the same composition in the absence of ethanol with the reverse-phase evaporation method. Vesicle size was measured by photon correlation spectroscopy (PCS), evidencing smaller mean diameters and narrower dimensional distributions in the case of ethosomes with respect to liposomes. In order to obtain homogeneously sized vesicles, both ethosomal and liposomal dispersions were extruded through polycarbonate membranes with pores of calibrated diameter (400 nm and 200 nm). Vesicle morphology was characterized by freeze-fracture scanning electron microscopy (SEM) showing the presence of unilamellar vesicles both in liposome- and in ethosome-based dispersions. Free energy measurements of the vesicle bilayers were conducted by differential scanning calorimetry (DSC). AA diffusion from ethosomal or liposomal dispersions and from ethosomes and liposomes incorporated in a viscous gel was investigated by a Franz cell assembled with synthetic membranes. The release rate was more rapid from ethosomal systems than from liposomal systems. In particular, ethosomes produced by the highest ethanol concentration released AA more rapidly, and the same trend was found using viscous forms.

  15. Infra-Free® (IF) Architecture System as the Method for Post-Disaster Shelter Model

    Science.gov (United States)

    Chang, Huai-Chien; Anilir, Serkan

    Currently, International Space Station (ISS) is capable to support 3 to 4 astronauts onboard for at least 6 months using an integrated life support system to support the need of crew onboard. Waste from daily life of the crew members are collected by waste recycle systems, electricity consumption depends on collecting solar energy, etc. though it likes the infrastructure we use on Earth, ISS can be comprehended nearly a self-reliant integrated architecture so far, this could be given an important hint for current architecture which is based on urban centralized infrastructure to support our daily lives but could be vulnerable in case of nature disasters. Comparatively, more and more economic activities and communications rely on the enormous urban central infrastructure to support our daily lives. Therefore, when in case of natural disasters, it may cut-out the infrastructure system temporarily or permanent. In order to solve this problem, we propose to design a temporary shelter, which is capable to work without depending on any existing infrastructure. We propose to use some closed-life-cycle or integrated technologies inspired by the possibilities of space and other emerging technologies into current daily architecture by using Infra-free® design framework; which proposes to integrate various life supporting infrastructural elements into one-closed system. We try to work on a scenario for post-disaster management housing as the method for solving the lifeline problems such as solid and liquid waste, energy, and water and hygiene solution into one system. And trying to establish an Infra-free® model of shelter for disaster area. The ultimate objective is to design a Temp Infra-free® model dealing with the sanitation and environment preservation concerns for disaster area.

  16. Topics in quantum foundations: Ontological models, and distinguishability as a resource

    Science.gov (United States)

    Morris, Ryan

    This thesis covers research in two disjoint research areas: The ontological model program (formerly hidden-variables program) for quantum theory has a long and noble tradition in the quantum foundations literature. By postulating a physical reality beyond the quantum state, we gain intuition on quantum phenomena and also come to understand constraints on realist interpretations of quantum theory. Bell's theorem tells us that such an underlying reality must be non-local, while the Kochen-Specker contextuality theorem abuses the classical notion that measurement should simply reveal pre-existing properties of reality. Recent research programs suggest that it is beneficial to view the quantum state as representing purely information. We show that the only current model which does this in a satisfactory manner is unable to reproduce all the statistics of quantum measurements. A recent generalization of the notion of contextuality has allowed for proofs of contextuality which differ from the original Kochen-Specker notion. We add a new result which shows that measurements in a model where the quantum state represents information must be contextual. Additionally, we refine the generalized notion of contextuality into strong and weak forms in order to parse the relationship between new and old results. Entanglement resource theory is a highly successful investigation of the usefulness of entanglement for information processing tasks. In this thesis we apply the ideas from entanglement resource theory to another resource: state distinguishability. We show analogies between distinguishability resource theory and entanglement resource theory. In particular, the analogy includes: measures which are monotonic under a class of transformations; units of a resource; and bounds on measures in terms of the amount of the unit resource needed to form states and the amount of unit resource that can be extracted from states. We show that the pairs of states which can be reversibly

  17. Systemic Architecture

    DEFF Research Database (Denmark)

    Poletto, Marco; Pasquero, Claudia

    2012-01-01

    design protocols developed to describe the city as a territory of self-organization. Collecting together nearly a decade of design experiments by the authors and their practice, ecoLogicStudio, the book discusses key disciplinary definitions such as ecologic urbanism, algorithmic architecture, bottom......-up or tactical design, behavioural space and the boundary of the natural and the artificial realms within the city and architecture. A new kind of "real-time world-city" is illustrated in the form of an operational design manual for the assemblage of proto-architectures, the incubation of proto......-gardens and the coding of proto-interfaces. These prototypes of machinic architecture materialize as synthetic hybrids embedded with biological life (proto-gardens), computational power, behavioural responsiveness (cyber-gardens), spatial articulation (coMachines and fibrous structures), remote sensing (FUNclouds...

  18. TXA497 as a topical antibacterial agent: comparative antistaphylococcal, skin deposition, and skin permeation studies with mupirocin.

    Science.gov (United States)

    Dorrani, Mania; Kaul, Malvika; Parhi, Ajit; LaVoie, Edmond J; Pilch, Daniel S; Michniak-Kohn, Bozena

    2014-12-10

    TXA497 is representative of a new class of guanidinomethyl biaryl compounds that exhibit potent bactericidal behavior against methicillin-resistant Staphylococcus aureus (MRSA). In this study, we compared the anti-staphylococcal, skin deposition, and skin permeation properties of TXA497 and the topical anti-MRSA antibiotic mupirocin. The results of minimum inhibitory concentration (MIC) assays revealed that TXA497 retains potent activity against MRSA that is highly resistant to mupirocin. Using Franz diffusion cells, compound deposition into human cadaver skin was evaluated, and the results showed the skin deposition of TXA497 to be significantly greater than that of mupirocin. Moreover, unlike mupirocin, TXA497 does not pass through the entire skin layer, suggesting a minimal potential for the systemic absorption of the compound upon topical administration. Additionally, antibacterial concentrations of TXA497 showed no significant toxicity to primary human keratinocytes. Given the rising levels of mupirocin resistance among MRSA populations, our results are significant in that they highlight TXA497 as a potentially useful alternative therapy for treating MRSA skin infections that are resistant to mupirocin.

  19. Exploring the Abyss. The Financial Crisis of 2008 ff. as a Central Topic of Problem-Centered Social Science Education

    Directory of Open Access Journals (Sweden)

    Thorsten Hippe

    2010-07-01

    Full Text Available The financial crisis of 2008 ff. and financial crises in general should be a central topic of social science education because these crises are a recurrent and therefore structural feature of modern capitalism which has severe consequences for citizens’ quality of life. Hence, the citizenry should know how to prevent such developments which endanger its well-being in a massive way. Therefore, learners should understand the relationship between the quality of people’s everyday lives and those economic institutions and political decisions which have led to the current mess. They should be enabled to critically evaluate the current misregulation of the financial sector and the economy in order to identify possible policy measures to prevent or at least to mitigate future crises. By educating (young citizens in this way, the (future general public can – as a necessary counterweight to the lobbyism of the finance industry – exert more prudent political pressure which gives politicians a greater incentive to regulate the financial sector and the economy in a manner which is beneficial for the vast majority of the people instead of for a small elite. Two core concepts of the social sciences can be used to make the roots of the seemingly complex topic more understandable for learners: liability and inequality.

  20. Thermosensitive chitosan-based hydrogel as a topical ocular drug delivery system of latanoprost for glaucoma treatment.

    Science.gov (United States)

    Cheng, Yung-Hsin; Tsai, Tung-Hu; Jhan, Yong-Yu; Chiu, Allen Wen-hsiang; Tsai, Kun-Ling; Chien, Chian-Shiu; Chiou, Shih-Hwa; Liu, Catherine Jui-lin

    2016-06-25

    Ocular hypertension is a major risk factor for the development and progression of glaucoma. Frequent and long-term application of latanoprost often causes undesirable local side effects, which are a major cause of therapeutic failure due to loss of persistence in using this glaucoma medical therapy. In the present study, we developed a thermosensitive chitosan-based hydrogel as a topical eye drop formulation for the sustained release of latanoprost to control ocular hypertension. The developed formulation without preservatives may improve compliance and possibly even efficacy. The results of this study support its biocompatibility and sustained-release profile both in vitro and in vivo. After topical application of latanoprost-loaded hydrogel, triamcinolone acetonide-induced elevated intraocular pressure was significantly decreased within 7 days and remained at a normal level for the following 21 days in rabbit eyes. This newly developed chitosan-based hydrogel may provide a non-invasive alternative to traditional anti-glaucoma eye drops for glaucoma treatment.

  1. The Emergence of Agent-Based Technology as an Architectural Component of Serious Games

    Science.gov (United States)

    Phillips, Mark; Scolaro, Jackie; Scolaro, Daniel

    2010-01-01

    The evolution of games as an alternative to traditional simulations in the military context has been gathering momentum over the past five years, even though the exploration of their use in the serious sense has been ongoing since the mid-nineties. Much of the focus has been on the aesthetics of the visuals provided by the core game engine as well as the artistry provided by talented development teams to produce not only breathtaking artwork, but highly immersive game play. Consideration of game technology is now so much a part of the modeling and simulation landscape that it is becoming difficult to distinguish traditional simulation solutions from game-based approaches. But games have yet to provide the much needed interactive free play that has been the domain of semi-autonomous forces (SAF). The component-based middleware architecture that game engines provide promises a great deal in terms of options for the integration of agent solutions to support the development of non-player characters that engage the human player without the deterministic nature of scripted behaviors. However, there are a number of hard-learned lessons on the modeling and simulation side of the equation that game developers have yet to learn, such as: correlation of heterogeneous systems, scalability of both terrain and numbers of non-player entities, and the bi-directional nature of simulation to game interaction provided by Distributed Interactive Simulation (DIS) and High Level Architecture (HLA).

  2. Architecture as animate landscape: circular shrines in the ancient Maya lowlands.

    Science.gov (United States)

    Harrison-Buck, Eleanor

    2012-01-01

    In this study, I develop a theory of landscape archaeology that incorporates the concept of “animism” as a cognitive approach. Current trends in anthropology are placing greater emphasis on indigenous perspectives, and in recent decades animism has seen a resurgence in anthropological theory. As a means of relating in (not to) one's world, animism is a mode of thought that has direct bearing on landscape archaeology. Yet, Americanist archaeologists have been slow to incorporate this concept as a component of landscape theory. I consider animism and Nurit Bird-David's (1999) theory of “relatedness” and how such perspectives might be expressed archaeologically in Mesoamerica. I examine the distribution of marine shells and cave formations that appear incorporated as architectural elements on ancient Maya circular shrine architecture. More than just “symbols” of sacred geography, I suggest these materials represent living entities that animate shrines through their ongoing relationships with human and other-than-human agents in the world.

  3. Architectural Mealscapes

    DEFF Research Database (Denmark)

    Tvedebrink, Tenna Doktor Olsen; Fisker, Anna Marie; Kirkegaard, Poul Henning

    2012-01-01

    the German architect Gottfried Semper developed a theory on the “four elements of Architecture” tracing the origin of architecture back to the rise of the early human settlement and the creation of fire. With the notion ‘hearth’ as the first motive in architecture and the definition of three enclosing...... motives; mounding, enclosure and roof, Semper linked the cultural and social values of the primordial fireplace with the order and shape of architecture. He claimed that any building ever made was nothing but a variation of the first primitive shelters erected around the fireplace, and that the three...... enclosing motives existed only as defenders of the “sacred flame”. In that way Semper developed the idea that any architectural scenery can be described, analyzed and explained by understanding the contextual, symbolic and social values of how the four basic motives of hearth, mounding, enclosure, and roof...

  4. Superficial keratectomy and topical mitomycin C as therapy for a corneal squamous cell carcinoma in a dog.

    Science.gov (United States)

    Karasawa, K; Matsuda, H; Tanaka, A

    2008-04-01

    A 10-year-old female West Highland white terrier was presented with refractory hyperplastic keratitis of the left cornea of one month's duration. At this time, a vascularised and rough lesion 5 mm in diameter was observed on the left cornea. No other abnormality was recognised on the affected eye. The corneal neoplasm was surgically removed and histologically diagnosed as a squamous cell carcinoma. For two months after the surgery, 0.04 percent mitomycin C (MMC) eye drops were applied as adjuvant chemotherapy. Primary corneal squamous cell carcinoma with no history of keratoconjunctivitis sicca is rare in dogs. In the present report, surgical removal of the neoplasm was combined with the topical administration of the anticancer drug mitomycin C and a good prognosis was obtained. The result indicates that the combination treatment used in this case may be an appropriate therapeutic choice for corneal squamous cell carcinoma in dogs.

  5. Multi-Sensor As-Built Models of Complex Industrial Architectures

    Directory of Open Access Journals (Sweden)

    Jean-François Hullo

    2015-12-01

    Full Text Available In the context of increased maintenance operations and generational renewal work, a nuclear owner and operator, like Electricité de France (EDF, is invested in the scaling-up of tools and methods of “as-built virtual reality” for whole buildings and large audiences. In this paper, we first present the state of the art of scanning tools and methods used to represent a very complex architecture. Then, we propose a methodology and assess it in a large experiment carried out on the most complex building of a 1300-megawatt power plant, an 11-floor reactor building. We also present several developments that made possible the acquisition, processing and georeferencing of multiple data sources (1000+ 3D laser scans and RGB panoramic, total-station surveying, 2D floor plans and the 3D reconstruction of CAD as-built models. In addition, we introduce new concepts for user interaction with complex architecture, elaborated during the development of an application that allows a painless exploration of the whole dataset by professionals, unfamiliar with such data types. Finally, we discuss the main feedback items from this large experiment, the remaining issues for the generalization of such large-scale surveys and the future technical and scientific challenges in the field of industrial “virtual reality”.

  6. The Wall as a Spatial Work: the Reliefs of Jorge Oteiza in Architecture (1951-58

    Directory of Open Access Journals (Sweden)

    Emma López Bahut

    2014-03-01

    Full Text Available This paper analyses the mural projects of Basque sculptor Jorge Oteiza on façades and internal walls between the years 1951-58. At first, he dealt with walls as ground planes on which to execute his sculptures, finally viewing them as an empty plane with spatial possibilities, defined by the minimum forms and the action of natural light. Based on original, previously unpublished material, we explore the evolution of this work with the aim of establishing to what extent this process was marked by the architecture on which his work was executed, by the architects with whom he collaborated, or the stage of his sculptural experimentation with which they are associated. We show that apart from the presence of an architect, there is a correlation between the way in which the reliefs were applied to the wall and the work carried out on the space where the project was created: the larger the spatial work on the wall, the greater the relationship with the space within which it was inserted, at every scale, from the interior of the architecture to the urban space.

  7. Can You Hear Architecture

    DEFF Research Database (Denmark)

    Ryhl, Camilla

    2016-01-01

    Taking an off set in the understanding of architectural quality being based on multisensory architecture, the paper aims to discuss the current acoustic discourse in inclusive design and its implications to the integration of inclusive design in architectural discourse and practice as well...... design and architectural quality for people with a hearing disability and a newly conducted qualitative evaluation research in Denmark as well as architectural theories on multisensory aspects of architectural experiences, the paper uses examples of existing Nordic building cases to discuss the role...... of acoustics in both inclusive design and multisensory architecture....

  8. A Reference Architecture for Provisioning of Tools as a Service: Meta-Model, Ontologies and Design Elements

    DEFF Research Database (Denmark)

    Chauhan, Muhammad Aufeef; Babar, Muhammad Ali; Sheng, Quan Z.

    2016-01-01

    Software Architecture (SA) plays a critical role in designing, developing and evolving cloud-based platforms that can be used to provision different types of services to consumers on demand. In this paper, we present a Reference Architecture (RA) for designing cloud-based Tools as a service SPACE...... (TSPACE) for provisioning a bundled suite of tools by following the Software as a Service (SaaS) model. The reference architecture has been designed by leveraging information structuring approaches and by using well-known architecture design principles and patterns. The RA has been documented using view......-based approach and has been presented in terms of its context, goals, the RA meta-model, information structuring and relationship models using ontologies and components of the RA. We have demonstrated the feasibility and applicability of the RA with the help of a prototype and have used the prototype...

  9. Architectural Engineers

    DEFF Research Database (Denmark)

    Petersen, Rikke Premer

    engineering is addresses from two perspectives – as an educational response and an occupational constellation. Architecture and engineering are two of the traditional design professions and they frequently meet in the occupational setting, but at educational institutions they remain largely estranged......The design professions have always been an amorphous phenomena difficult to merge under one label. New constellations continually emerge, questioning, stretching, and reconfiguring the understanding of design and the professional practices linked to it. In this paper the idea of architectural....... The paper builds on a multi-sited study of an architectural engineering program at the Technical University of Denmark and an architectural engineering team within an international engineering consultancy based on Denmark. They are both responding to new tendencies within the building industry where...

  10. Art as behaviour--an ethological approach to visual and verbal art, music and architecture.

    Science.gov (United States)

    Sütterlin, Christa; Schiefenhövel, Wulf; Lehmann, Christian; Forster, Johanna; Apfelauer, Gerhard

    2014-01-01

    In recent years, the fine arts, architecture, music and literature have increasingly been examined from the vantage point of human ethology and evolutionary psychology. In 2011 the authors formed the research group 'Ethology of the Arts' concentrating on the evolution and biology of perception and behaviour. These novel approaches aim at a better understanding of the various facets represented by the arts by taking into focus possible phylogenetic adaptations, which have shaped the artistic capacities of our ancestors. Rather than culture specificity, which is stressed e.g. by cultural anthropology and numerous other disciplines, universal human tendencies to perceive, feel, think and behave are postulated. Artistic expressive behaviour is understood as an integral part of the human condition, whether expressed in ritual, visual, verbal or musical art. The Ethology of the Arts-group's research focuses on visual and verbal art, music and built environment/architecture and is designed to contribute to the incipient interdisciplinarity in the field of evolutionary art research.

  11. Choice Architecture as a Way to Encourage a Whole Systems Design Perspective for More Sustainable Infrastructure

    Directory of Open Access Journals (Sweden)

    Nora Harris

    2016-12-01

    Full Text Available Across fields, more sustainable and resilient outcomes are being realized through a whole systems design perspective, which guides decision-makers to consider the entire system affected including interdependent physical and social networks. Although infrastructure is extremely interdependent, consisting of diverse stakeholders and networks, the infrastructure design and construction process is often fragmented. This fragmentation can result in unnecessary tradeoffs, leading to poor outcomes for certain stakeholders and the surrounding environment. A whole systems design perspective would help connect this fragmented industry and lead to more sustainable outcomes. For example, a whole systems design approach to relieve traffic on a highway might see beyond the obvious, but often ineffective, response of adding a new vehicle lane to encourage a solution such as repurposing existing road lanes from automobiles to above-ground “subway” systems. This paper discusses influences to whole systems design and how intentional choice architecture, meaning the way decisions are posed, can nudge decision-makers to employ whole systems design and result in more sustainable infrastructure. By uncovering these influences and organizing them by the social, organizational, and individual levels of the infrastructure design process, this paper provides the needed foundation for interdisciplinary research to help harness these influences through choice architecture and whole systems design for the infrastructure industry.

  12. Affective Architecture. Film as a Sensory Transference Tool and an Intimacy Projection Environment

    DEFF Research Database (Denmark)

    Petersen, Rikke Munck; Farsø, Mads

    2016-01-01

    This paper elucidates how film may offer itself as a tool for both the representation and conception of space that can strengthen an alternative, phenomenological and transcendental position in architecture. The paper underscores that the film camera can work as a kind of amplifier of how we......, with our bodies, perceive space and project space. Through an analysis of two films, it points to the medium of film as both a tool and an environment, based on Gernot Böhme’s ‘Raum leiblicher Anwesenheit (Böhme 2006). These films illustrate how the film’s picture frame becomes almost like a skin...... and through its surface and sound projects both a site and a near-sensual experience simultaneously. The medium of film as both tool and an environment thereby supports an extended sensory-intimate reflection on outer experiences and inner sensations that – in its audio-visual and time...

  13. Histatin 5-spermidine conjugates have enhanced fungicidal activity and efficacy as a topical therapeutic for oral candidiasis.

    Science.gov (United States)

    Tati, Swetha; Li, Rui; Puri, Sumant; Kumar, Rohitashw; Davidow, Peter; Edgerton, Mira

    2014-01-01

    Oropharyngeal candidiasis (OPC) is caused by the opportunistic fungi Candida albicans and is prevalent in immunocompromised patients, individuals with dry mouth, or patients with prolonged antibiotic therapies that reduce oral commensal bacteria. Human salivary histatins, including histatin 5 (Hst 5), are small cationic proteins that are the major source of fungicidal activity of saliva. However, Hsts are rapidly degraded in vivo, limiting their usefulness as therapeutic agents despite their lack of toxicity. We constructed a conjugate peptide using spermidine (Spd) linked to the active fragment of Hst 5 (Hst 54-15), based upon our findings that C. albicans spermidine transporters are required for Hst 5 uptake and fungicidal activity. We found that Hst 54-15-Spd was significantly more effective in killing C. albicans and Candida glabrata than Hst 5 alone in both planktonic and biofilm growth and that Hst 54-15-Spd retained high activity in both serum and saliva. Hst 54-15-Spd was not bactericidal against streptococcal oral commensal bacteria and had no hemolytic activity. We tested the effectiveness of Hst 54-15-Spd in vivo by topical application to tongue surfaces of immunocompromised mice with OPC. Mice treated with Hst 54-15-Spd had significant clearance of candidal tongue lesions macroscopically, which was confirmed by a 3- to 5-log fold reduction of C. albicans colonies recovered from tongue tissues. Hst 54-15-Spd conjugates are a new class of peptide-based drugs with high selectivity for fungi and potential as topical therapeutic agents for oral candidiasis.

  14. The architecture of the four-īwān building tradition as a representation of paradise and dynastic power aspirations

    NARCIS (Netherlands)

    Paskaleva, Elena Georgieva

    2010-01-01

    The dissertation analyses how architecture represents sacred realities. The main focus is on Tīmūrid architecture as an instrument to legitimize extreme and universal power. The four-īwān plan is examined as a dynastic architectural tool marking the centre of the world, from which power spreads alon

  15. Carbon nanotube-ZnO nanowire hybrid architectures as multifunctional devices

    Directory of Open Access Journals (Sweden)

    L. T. Singh

    2013-08-01

    Full Text Available We report on multifunctional devices based on CNT arrays-ZnO nanowires hybrid architectures. The hybrid structure exhibit excellent high current Schottky like behavior with ZnO as p-type and an ideality factor close to the ideal value. Further the CNT-ZnO hybrid structures can be used as high current p-type field effect transistors that can deliver currents of the order of milliamperes and also can be used as ultraviolet detectors with controllable current on-off ratio and response time. The p-type nature of ZnO and possible mechanism for the rectifying characteristics of CNT-ZnO has been presented.

  16. Synthetic Ni3S2/Ni hybrid architectures as potential contrast agents in MRI

    Science.gov (United States)

    Ma, J.; Chen, K.

    2016-04-01

    Traditional magnetic resonance imaging (MRI) contrast agents mainly include superparamagnetic (SPM) iron oxide nanoparticle as T 2 contrast agent for liver and paramagnetic Gd (III)-chelate as T 1 contrast agent for all organs. In this work, weak ferromagnetic kale-like and SPM cabbage-like Ni3S2@Ni hybrid architectures were synthesized and evaluated as potential T 1 MRI contrast agents. Their relatively small r 2/r 1 ratios of 2.59 and 2.38, and high r 1 values of 11.27 and 4.89 mmol-1 L s-1 (for the kale-like and cabbage-like Ni3S2@Ni, respectively) will shed some light on the development of new-type MRI contrast agents.

  17. MOSQUE ARCHITECTURE AS A SUSTAINABLE BUILDING IN URBAN (Case Study: Al Markas Al Islamic Mosque Makassar

    Directory of Open Access Journals (Sweden)

    Imriyanti Imriyanti

    2014-02-01

    Full Text Available Abstract Mosque Architecture is a part of Islamic architecture. Mosque should be fused with elements of nature because its function as a place to pray to God who created the universe. Al Markas Al Islamic Makassar mosque is used as a center of Islamic aspirations of the people and the government to accommodate all the activities of moslems in Makassar. Through this function, the provision of Al Markas Al Islamic mosque began from the desire of Islamic societies in Makassar, which wants the Islamic center to be equipped with facilities and infrastructure as well as architectural, monumental buildings and structures that can be last for hundreds of years (continuous, blend with the environment, and also can be used by the public. Having regard to the function of a mosque especially at the Al Markas Al Islamic Makassar mosque, then the problem that arise is how the Al Markas Al Islamic mosque can be survived/sustainable  in order  to function  as a place  of worship  and  as a center  of Islam.  This research  is a descriptive qualitative research that is trying to generate data in the form of systematic and accurate picture of the object of study. The sustaiprophetlity  of Al Markas AL Islamic mosque can be known through the concept of Islam  in accordance with the view of Islam as well as the sustaiprophetlity of the buildings that seen in the spatial pattern of the mosque, appearance, natural lighting, natural ventilation, and user behavior of the mosque. Keywords: mosque architecture, sustaiprophetlity, view of Islam     Abstrak Arsitektur masjid merupakan bagian dari arsitektur Islam. Bangunan masjid sebaiknya dapat menyatu dengan unsur alam karena masjid difungsikan sebagai wadah dalam bersujud/sembahyang  kepada Allah SWT yang menciptakan alam semesta ini. Masjid Al Markas Al Islamic Makassar merupakan kompleks kegiatan Islam yang digunakan sebagai pusat aspirasi masyarakat  dan pemerintahan  yang dapat menampung

  18. Cellular Automata as a learning process in Architecture and Urban design

    DEFF Research Database (Denmark)

    Jensen, Mads Brath; Foged, Isak Worre

    2014-01-01

    . An architectural methodological response to this situation is presented through the development of a conceptual computational design system that allows these dynamics to unfold and to be observed for architectural design decision taking. Reflecting on the development and implementation of a cellular automata based...

  19. Urban Architecture as Connective-Collective Intelligence. Which Spaces of Interaction?

    Directory of Open Access Journals (Sweden)

    Marco Simonetti

    2013-07-01

    Full Text Available During the twentieth century, with the advent of industrial society and globalization, the language of planning changed according to the shifts in construction and use of physical space. By borrowing terms and spatial forms from biology and cybernetics, industrial society and globalization increased the original semantic connotations. Moving from cognitive sciences, this paper outlines the definition of architecture as connective-collective intelligence and presents its implication in urban design. Spontaneous and commercial initiatives are redefining the communication form of urban life, affecting the procedures of the transmission of traditional knowledge. This approach to building environment is moving towards a complex multichannel interaction, involving both the individual and the collective experiences of space and technology. In describing some signs of that process, the authors outline new features that are changing the concept of sustainability in urban design.

  20. SUSTAINABLE ARCHITECTURE : WHAT ARCHITECTURE STUDENTS THINK

    OpenAIRE

    SATWIKO, PRASASTO

    2013-01-01

    Sustainable architecture has become a hot issue lately as the impacts of climate change become more intense. Architecture educations have responded by integrating knowledge of sustainable design in their curriculum. However, in the real life, new buildings keep coming with designs that completely ignore sustainable principles. This paper discusses the results of two national competitions on sustainable architecture targeted for architecture students (conducted in 2012 and 2013). The results a...

  1. Water-filtered infrared-A (wIRA) can act as a penetration enhancer for topically applied substances

    OpenAIRE

    Sterry, Wolfram; Ackermann, Hanns; Hoffmann, Gerd; Schanzer, Sabine; Meyer, Lars; Grone, Diego; Otberg, Nina; Lademann, Jürgen

    2008-01-01

    Background: Water-filtered infrared-A (wIRA) irradiation has been shown to enhance penetration of clinically used topically applied substances in humans through investigation of functional effects of penetrated substances like vasoconstriction by cortisone. Aim of the study: Investigation of the influence of wIRA irradiation on the dermatopharmacokinetics of topically applied substances by use of optical methods, especially to localize penetrating substances, in a prospective randomised contr...

  2. Migrating EO/IR sensors to cloud-based infrastructure as service architectures

    Science.gov (United States)

    Berglie, Stephen T.; Webster, Steven; May, Christopher M.

    2014-06-01

    The Night Vision Image Generator (NVIG), a product of US Army RDECOM CERDEC NVESD, is a visualization tool used widely throughout Army simulation environments to provide fully attributed synthesized, full motion video using physics-based sensor and environmental effects. The NVIG relies heavily on contemporary hardware-based acceleration and GPU processing techniques, which push the envelope of both enterprise and commodity-level hypervisor support for providing virtual machines with direct access to hardware resources. The NVIG has successfully been integrated into fully virtual environments where system architectures leverage cloudbased technologies to various extents in order to streamline infrastructure and service management. This paper details the challenges presented to engineers seeking to migrate GPU-bound processes, such as the NVIG, to virtual machines and, ultimately, Cloud-Based IAS architectures. In addition, it presents the path that led to success for the NVIG. A brief overview of Cloud-Based infrastructure management tool sets is provided, and several virtual desktop solutions are outlined. A discrimination is made between general purpose virtual desktop technologies compared to technologies that expose GPU-specific capabilities, including direct rendering and hard ware-based video encoding. Candidate hypervisor/virtual machine configurations that nominally satisfy the virtualized hardware-level GPU requirements of the NVIG are presented , and each is subsequently reviewed in light of its implications on higher-level Cloud management techniques. Implementation details are included from the hardware level, through the operating system, to the 3D graphics APls required by the NVIG and similar GPU-bound tools.

  3. Architectural and morphological assessment of rat abdominal wall muscles: comparison for use as a human model.

    Science.gov (United States)

    Brown, Stephen H M; Banuelos, Karina; Ward, Samuel R; Lieber, Richard L

    2010-09-01

    The abdominal wall is a composite of muscles that are important for the mechanical stability of the spine and pelvis. Tremendous clinical attention is given to these muscles, yet little is known about how they function in isolation or how they interact with one another. Given the morphological, vascular, and innervation complexities associated with these muscles and their proximity to the internal organs, an appropriate animal model is important for understanding their physiological and mechanical significance during function. To determine the extent to which the rat abdominal wall resembles that of human, 10 adult male Sprague-Dawley rats were killed and formalin-fixed for architectural and morphological analyses of the four abdominal wall muscles (rectus abdominis, external oblique, internal oblique, and transversus abdominis). Physiological cross-sectional areas and optimal fascicle lengths demonstrated a pattern that was similar to human abdominal wall muscles. In addition, sarcomere lengths measured in the neutral spine posture were similar to human in their relation to optimal sarcomere length. These data indicate that the force-generating and length change capabilities of these muscles, relative to one another, are similar in rat and human. Finally, the fiber lines of action of each abdominal muscle were similar to human over most of the abdominal wall. The main exception was in the lower abdominal region (inferior to the pelvic crest), where the external oblique becomes aponeurotic in human but continues as muscle fibers into its pelvic insertion in the rat. We conclude that, based on the morphology and architecture of the abdominal wall muscles, the adult male Sprague-Dawley rat is a good candidate for a model representation of human, particularly in the middle and upper abdominal wall regions.

  4. Water-filtered infrared-A (wIRA can act as a penetration enhancer for topically applied substances

    Directory of Open Access Journals (Sweden)

    Sterry, Wolfram

    2008-07-01

    increased penetration depth compared to the non-irradiated skin (mode A: The ratio of the amount of the dye in the deeper (second 10% of the stratum corneum to the amount of the dye in the upper 10% of the stratum corneum showed medians and interquartile ranges for mode A of 0.017 (0.007/0.050, for mode B of 0.084 (0.021/0.106, for mode C of 0.104 (0.069/0.192 (difference between modes: p=0.0112, significant; comparison mode A with mode C: p<0.01, significant. In contrast to fluorescein, the lipophilic curcumin showed no differences in the penetration kinetics, in reference to whether the skin was irradiated with wIRA or not. These effects were confirmed by laser scanning microscopy. Water-filtered infrared-A irradiation increased the hydration of the stratum corneum: transepidermal water loss rose from approximately 8.8 g m-2 h-1 before wIRA irradiation to 14.2 g m-2 h-1 after wIRA irradiation and skin hydration rose from 67 to 87 relative units. Skin surface temperature increased from 32.8°C before wIRA to 36.4°C after wIRA irradiation. Discussion: The better penetration of the hydrophilic dye fluorescein after or during skin irradiation (modes B and C can be explained by increased hydration of the stratum corneum by irradiation with wIRA. Conclusions: As most topically applied substances for the treatment of patients are mainly hydrophilic, wIRA can be used to improve the penetration of substances before or after application of substances – in the first case even of thermolabile substances – with a broad clinical relevance as a contact free alternative to an occlusive dressing.

  5. A case of topical opioid-induced delirium mistaken as behavioural and psychological symptoms of dementia in demented state.

    Science.gov (United States)

    Ito, Go; Kanemoto, Kousuke

    2013-06-01

    In Japan, indications for opioid analgesics, once exclusively used as pain killers for patients suffering from malignant cancer, have been expanded for a wide range of pain. Herein we report a patient with opioid-induced delirium associated with the administration of buprenorphine patches that was well below the indicated therapeutic range limit. An 82-year-old woman was referred to us from an orthopaedic practitioner for uncontrollable behavioural problems apparently caused by the beginning of dementia; the patient had gradually developed disorientation, visual hallucinations, and delusions. Laboratory and imaging findings excluded common causes of delirium including Alzheimer's disease and diffuse Lewy body disease. Detailed questioning revealed that the patient's confused state appeared following a buprenorphine patch dose increase and subsequently disappeared after administration was stopped. Delirium has not been reported as a side-effect in clinical trials of buprenorphine patches. However, our findings in this case show that even topical opioids can precipitate the development of a delirious state in elderly patients.

  6. Preoperative subconjunctival injection of mitomycin C versus intraoperative topical application as an adjunctive treatment for surgical removal of primary pterygium

    Directory of Open Access Journals (Sweden)

    Ehab M Ghoneim

    2011-01-01

    Materials and Methods : Seventy eyes of 70 patients with primary pterygia were randomly allocated to two groups. The first group (Group A, 35 eyes received 0.1 ml of 0.15 mg/ml of subconjunctival MMC injected into the head of the pterygium 24 h before surgical excision with the bare sclera technique. The second group (Group B 35 eyes underwent surgical removal with the bare sclera technique with intraoperative application of MMC (0.15 mg/ml over bare sclera for 3 min. The study was performed between March 2007 and December 2008, and follow up was performed for 1 year postoperatively. Differences between frequencies in both groups were compared by the Chi-square test or Fisher exact test. Differences between means in both groups were compared by Student′s t-test. P 0.05. Postoperatively, scleral thinning occurred in one eye in each group that resolved by 5 months postoperatively. No serious postoperative complications occurred in either group. Conclusion : Preoperative local injection of 0.15 mg/ml MMC is as effective as intraoperative topical application of 0.15 mg/ml MMC for preventing pterygium recurrence after surgical removal.

  7. Place-Based Education in the Architectural Design Studio: Agrarian Landscape as a Resource for Sustainable Urban Lifestyle

    Directory of Open Access Journals (Sweden)

    Ana Nikezić

    2015-07-01

    Full Text Available This article highlights how “place-based education” can be used to raise awareness about sustainability and potentially influence design process decisions that have environmental and cultural implications. “Place-based education” is a term used to describe an educational worldview based on development of curriculum centered on the local, social, economic, and ecological resources of a community. The study shows results of Masters Students’ research on situating a housing complex in the context of the agrarian landscape of Vojvodina, Serbia, considering it as a resource for a new sustainable urban lifestyle. During the first year of Masters Studies at the Faculty of Architecture, Belgrade University, an architectural design studio with 15 students had the task of exploring the potential of expanding the city of Belgrade across the agrarian landscape, as to affirm the role of place in contemporary everyday life. Students were expected to explore the possibilities and limitations of the relationship between man and agrarian landscape via architecture, re-thinking how various architectural design approaches could balance and harmonize the impact of the built environment on the agrarian landscape. The paper shows that “place-based education” possesses elements necessary for the inclusion of a wider spatial-cultural context in the process of architectural design and prioritization of environmental literacy and responsibility, as one of the main components of sustainable development.

  8. Flowscapes: Infrastructure as landscape, landscape as infrastructure. Graduation Lab Landscape Architecture 2012/2013

    NARCIS (Netherlands)

    Nijhuis, S.; Jauslin, D.; De Vries, C.

    2012-01-01

    Flowscapes explores infrastructure as a type of landscape and landscape as a type of infrastructure, and is focused on landscape architectonic design of transportation-, green- and water infrastructures. These landscape infrastructures are considered armatures for urban and rural development. With m

  9. BOLU, SEBEN DISTRICT, DEDELER VILLAGE CUMA MOSQUE CONSERVATION PROBLEMS AS A CASE OF RURAL ARCHITECTURE

    OpenAIRE

    Aksulu, B.Isık; Esen, Senem Ozbek

    2015-01-01

    Bolu, Dedeler Cuma Mosque is one of the rural religious architectural buildings reached to present day is located in Dedeler Village in Seben district. In order to determine the conservation problems of the mosque the studies have been conducted to document the current condition of the building, to assess the mosques which are similar to this mosque in terms of building type system plan layout and elements, to determine the demolished, changed and destroyed architectural elements of the build...

  10. Architecture, energy and climate

    DEFF Research Database (Denmark)

    Lauring, Michael

    2010-01-01

    Architecture has always had to relate to climatic conditions while providing shelter from the sun, the rain, the winds or the cold. This is a main purpose of buildings: To establish an indoor climate different from the outdoor. In the Nordic countries fuels for heating buildings has been a vital...... necessity almost as basic as food and water, and lack of wood has caused illness and migration - scarcity of energy is not a new topic either [Kjærgaard]. The new aspects are that human civilization is in danger of causing severe global climate changes, secondly that we can foresee using up the global non......-renewable reserves of oil, gas and uranium, both aspects capable of pulling the carpet under human civilization itself as we know it. The huge energy consumption especially in the northern hemisphere is closely linked to industrialization, and the response from those aware of energy and climate problems has in some...

  11. The fractal globule as a model of chromatin architecture in the cell.

    Science.gov (United States)

    Mirny, Leonid A

    2011-01-01

    The fractal globule is a compact polymer state that emerges during polymer condensation as a result of topological constraints which prevent one region of the chain from passing across another one. This long-lived intermediate state was introduced in 1988 (Grosberg et al. 1988) and has not been observed in experiments or simulations until recently (Lieberman-Aiden et al. 2009). Recent characterization of human chromatin using a novel chromosome conformational capture technique brought the fractal globule into the spotlight as a structural model of human chromosome on the scale of up to 10 Mb (Lieberman-Aiden et al. 2009). Here, we present the concept of the fractal globule, comparing it to other states of a polymer and focusing on its properties relevant for the biophysics of chromatin. We then discuss properties of the fractal globule that make it an attractive model for chromatin organization inside a cell. Next, we connect the fractal globule to recent studies that emphasize topological constraints as a primary factor driving formation of chromosomal territories. We discuss how theoretical predictions, made on the basis of the fractal globule model, can be tested experimentally. Finally, we discuss whether fractal globule architecture can be relevant for chromatin packing in other organisms such as yeast and bacteria.

  12. Colloidal Nanocrystalline Semiconductor Materials as Photocatalysts for Environmental Protection of Architectural Stone

    Directory of Open Access Journals (Sweden)

    Francesca Petronella

    2017-01-01

    Full Text Available Rod-shaped TiO2 nanocrystals (TiO2 NRs, capped by oleic acid molecules (OLEA, were synthesized with controlled size, shape and surface chemistry by using colloidal routes. They were investigated for application as coating materials for preserving architectural stone of monumental and archaeological interest, in consideration of their self-cleaning and protection properties. For this purpose, two different deposition techniques, namely casting and dipping, were tested for the application of a nanocrystal dispersion on a defined stone type, as a relevant example of porous calcarenites, namely the Pietra Leccese, a building stone widely used in monuments and buildings of cultural and historic interest of the Apulia region (Italy. The physical properties of the stone surface were investigated before and after the treatment with the prepared nanostructured materials. In particular, colour, wettability, water transfer properties and stability of the coating were monitored as a function of time and of the application method. The self-cleaning properties of the TiO2 NRs coated surfaces were tested under simulated and real solar irradiation. The obtained results were discussed in the light of the specific surface chemistry and morphology of TiO2 NRs, demonstrating the effectiveness of TiO2 NRs as an active component in formulations for stone protection.

  13. Textile Architecture

    DEFF Research Database (Denmark)

    Heimdal, Elisabeth Jacobsen

    2010-01-01

    Textiles can be used as building skins, adding new aesthetic and functional qualities to architecture. Just like we as humans can put on a coat, buildings can also get dressed. Depending on our mood, or on the weather, we can change coat, and so can the building. But the idea of using textiles...

  14. Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC).

    Science.gov (United States)

    Fang, Jia-You; Fang, Chia-Lang; Liu, Chi-Hsien; Su, Yu-Han

    2008-10-01

    Solid lipid nanoparticles (SLN) were developed by using Precirol ATO 5 as the solid core of the particles for topical psoralen delivery. Nanostructured lipid carriers (NLC) consisting of Precirol and squalene, a liquid lipid, were also prepared for comparison. SLN and NLC showed respective mean particle sizes of approximately 300 and 200nm, respectively. Viscosity, polarity, and differential scanning calorimetry (DSC) studies were performed to characterize the physicochemical properties of the SLN and NLC. The viscosity of all nanoparticulate systems exhibited Newtonian behavior except the NLC with Tween 80 and soybean phospholipids as the emulsifiers (NLC-Tw). According to the DSC thermograms, the melting peak of Precirol shifted from 58 to 55 degrees C after incorporating squalene into the solid lipid cores (of NLC), which suggests defects in the crystalline lattice of the lipid cores and smaller particle sizes. Three psoralen derivatives for psoriasis treatments were loaded in SLN and NLC to examine their ability to permeate skin. The permeability of psoralens increased in the order of 8-methoxypsoralen (8-MOP)>5-methoxypsoralen (5-MOP)>4,5,8-trimethylpsoralen (TMP). Enhanced permeation and controlled release of psoralen delivery were both achieved using the NLC. The in vitro permeation results showed that NLC-Tw increased the 8-MOP flux 2.8 times over that of a conventional emulsion. Hyperproliferative or psoriasis-like skin produced by repeated strippings in the dorsal skin of nude mouse was also used as a permeation barrier. The results showed that the entrapment of 8-MOP in nanoparticulate systems could minimize the permeation differentiation between normal and hyperproliferative skin compared to the free drug in an aqueous control.

  15. Architectural Anthropology

    DEFF Research Database (Denmark)

    Stender, Marie

    Architecture and anthropology have always had a common focus on dwelling, housing, urban life and spatial organisation. Current developments in both disciplines make it even more relevant to explore their boundaries and overlaps. Architects are inspired by anthropological insights and methods......, while recent material and spatial turns in anthropology have also brought an increasing interest in design, architecture and the built environment. Understanding the relationship between the social and the physical is at the heart of both disciplines, and they can obviously benefit from further...... collaboration: How can qualitative anthropological approaches contribute to contemporary architecture? And just as importantly: What can anthropologists learn from architects’ understanding of spatial and material surroundings? Recent theoretical developments in anthropology stress the role of materials...

  16. 作为观念的艺术与建筑%Art And Architecture--As A Kind Of Concept

    Institute of Scientific and Technical Information of China (English)

    张滨; 孔宇航

    2013-01-01

    西方近现代社会的变化和飞速发展是西方现当代建筑与艺术得以纷繁复杂变化的客观基础,社会形态的变化同样改变着建筑师和艺术家的观念,建筑师与艺术家在不断变化的时代中推动着自身观念的演变并将其转换成具体的实践,从这种意义来说,西方现当代建筑和艺术是一种观念的建筑和观念的艺术。作为观念的艺术与作为观念的建筑始终在相互影响和作用中呈现出崭新的局面。本文通过文艺复兴的人文主义思想观念下的建筑与艺术的并行同构到工业革命以来的技术理性观念支配下的文化破碎再到20世纪50年代后文化研究的崭新回归从艺术和建筑两方面展开讨论,探讨了观念的推演是艺术和建筑不断发展的核心的动力。%The objective foundation of numerous and complicated develop of western modern and contemporary architecture and art is changes in society and the rapid development. The changes on social formation also affect the concept of architects and artists.Architects and artists is sensitive to the changes of the times. In changing times, they continue to drive the evolution of their own concept and convert it into concrete practice.In this sense, the western modern and contemporary architecture and art is a conceptual architecture and art. Change in human concept promote the development of modern and contemporary architecture and art, present us a new look.Conceptual architecture and art influence and interaction each other reached a new phase.In this thesis, under a review of several stages:the Renaissance humanist ideas effect the paral el isomorphic of art and architecture ,concept of technical rationality bring the broken of culture since the industrial revolution and the new regression of cultural studies from the 1950s to present. Then open up the discussion from art and architecture two aspects and explore the topic: the deduction of the concept is

  17. Multithreading architecture

    CERN Document Server

    Nemirovsky, Mario

    2013-01-01

    Multithreaded architectures now appear across the entire range of computing devices, from the highest-performing general purpose devices to low-end embedded processors. Multithreading enables a processor core to more effectively utilize its computational resources, as a stall in one thread need not cause execution resources to be idle. This enables the computer architect to maximize performance within area constraints, power constraints, or energy constraints. However, the architectural options for the processor designer or architect looking to implement multithreading are quite extensive and

  18. A novel sputtered Pd mesh architecture as an advanced electrocatalyst for highly efficient hydrogen production

    Science.gov (United States)

    de Lucas-Consuegra, Antonio; de la Osa, Ana R.; Calcerrada, Ana B.; Linares, José J.; Horwat, David

    2016-07-01

    This study reports the preparation, characterization and testing of a sputtered Pd mesh-like anode as an advanced electrocatalyst for H2 production from alkaline ethanol solutions in an Alkaline Membrane Electrolyzer (AEM). Pd anodic catalyst is prepared by magnetron sputtering technique onto a microfiber carbon paper support. Scanning Electron Microscopy images reveal that the used preparation technique enables to cover the surface of the carbon microfibers exposed to the Pd target, leading to a continuous network that also maintains part of the original carbon paper macroporosity. Such novel anodic architecture (organic binder free) presents an excellent electro-chemical performance, with a maximum current density of 700 mA cm-2 at 1.3 V, and, concomitantly, a large H2 production rate with low energy requirement compared to water electrolysis. Potassium hydroxide emerges as the best electrolyte, whereas temperature exerts the expected promotional effect up to 90 °C. On the other hand, a 1 mol L-1 ethanol solution is enough to guarantee an efficient fuel supply without any mass transfer limitation. The proposed system also demonstrates to remain stable over 150 h of operation along five consecutives cycles, producing highly pure H2 (99.999%) at the cathode and potassium acetate as the main anodic product.

  19. A Reference Architecture for Providing Tools as a Service to Support Global Software Development

    DEFF Research Database (Denmark)

    Chauhan, Aufeef

    2014-01-01

    Global Software Development (GSD) teams encounter challenges that are associated with distribution of software development activities across multiple geographic regions. The limited support for performing collaborative development and engineering activities and lack of sufficient support for main......Global Software Development (GSD) teams encounter challenges that are associated with distribution of software development activities across multiple geographic regions. The limited support for performing collaborative development and engineering activities and lack of sufficient support...... specific constraints regarding availability and deployments of the tools. The artifacts and data produced or consumed by the tools need to be governed according to the constraints and corresponding quality of service (QoS) parameters. In this paper, we present the research agenda to leverage cloud......-computing paradigm for addressing above-mentioned issues by providing a framework to select appropriate tools as well as associated services and reference architecture of the cloud-enabled middleware platform that allows on demand provisioning of software engineering Tools as a Service (TaaS) with focus...

  20. On Detailing in Contemporary Architecture

    DEFF Research Database (Denmark)

    Kristensen, Claus; Kirkegaard, Poul Henning

    2010-01-01

    / tactility can blur the meaning of the architecture and turn it into an empty statement. The present paper will outline detailing in contemporary architecture and discuss the issue with respect to architectural quality. Architectural cases considered as sublime piece of architecture will be presented...

  1. The Modernization Concept as an Integrative Framework for the Methodology of Studying Topical Issues in Russian History

    Directory of Open Access Journals (Sweden)

    Yuri N. Smirnov

    2016-10-01

    Full Text Available The article is devoted to a number of methodological and concrete historical questions raised in the monograph by Boris Mironov, “The Russian Empire: From Tradition to Modernity.” The monograph is based on the modernization concept. The variety of methods and techniques borrowed by the author from different scientific disciplines and schools, but which demonstrate their usefulness, provide a reason to call his approach “integrative.” Smirnov shares Mironov’s perspective on the possibility of determining the laws of Russia’s historical path, and on the positive prospects for Russia’s movement upon it. Particular attention is paid to how Mironov examines and interprets the course of Russian colonization, its influence on the internal processes in society in general, and on the fate of specific regions and the ethnic groups. In Mironov’s opinion, the inclusion of new lands in Russia has had generally beneficial effects for the country as a whole and for the people who inhabit it. Smirnov engages in a thought experiment in order to assess in how far Mironov’s conclusions are applicable to the southeast of Russia. The results prove the validity of the conclusions and their applicability to research of other colonized territories. The reviewer recognizes as valid the opinion that the economic reserves of serfdom had not been exhausted by the middle of the 19th century. The liberation of the peasants was caused by many factors, among which moral and cultural reasons were not in the last place. The imperial “Enlightened” bureaucracy became the leader of peasant and other reforms. The article expressed disagreement that the strengthening of the position of the nobility and their power over the peasants in the 18th century was determined by the decisive role of the guard in palace coups. Mironov’s book will stimulate new research and discussions on topical issues of Russian history.

  2. Irritantcy potential and sub acute dermal toxicity study of Pistacia lentiscus fatty oil as a topical traditional remedy.

    Science.gov (United States)

    Djerrou, Zouhir; Djaalab, Hdria; Riachi, Foulla; Serakta, Mennouba; Chettoum, Aziez; Maameri, Zineb; Boutobza, Badaoui; Hamdi-Pacha, Youcef

    2013-01-01

    The current study was undertaken to assess safety of Pistacia lentiscus fruits fatty oil (PLFO) as a topical traditional remedy. A primary skin and eye irritation tests were conducted with New Zealand white rabbits to determine the potential for PLFO to produce irritation from a single application. In addition, a sub acute dermal toxicity study was performed on 18 NZW rabbits to evaluate possible adverse effect following application of PLFO for 28 days. Based on the results of the current study, PLFO is classified as slightly irritating to the skin and the eye of rabbits (Primary Irritation Index (P.I.I.) = 1.037; Ocular Irritation Index (O.I.I.) = 5.33 at 1 h). In the sub-acute toxicity test, PLFO produced neither mortality nor significant differences in the body and organ weights between control group and treated rabbits. However, a reversible irritant contact dermatitis was observed in the treated areas from the end of the second week of application until the end of experiment. This local phenomenon was accompanied by a significant skin thickening (P≤0.01) since the 12(th) day (ANOVA, F = 11, 07143, P = 0, 00765) which is confirmed with an inflammatory granuloma in histological study. Haematological analysis and blood chemistry values of the 2 groups showed no significant differences in any of the parameters examined. In summary, PLFO is minimally irritating to the eye and skin after a single exposure, but it may cause irritant contact dermatitis and a reversible thickening of skin after prolonged use.

  3. ARCHITECTURE OF PEROXISOMAL ALCOHOL OXIDASE CRYSTALS FROM THE METHYLOTROPHIC YEAST HANSENULA-POLYMORPHA AS DEDUCED BY ELECTRON-MICROSCOPY

    NARCIS (Netherlands)

    VONCK, J; VANBRUGGEN, EFJ

    1992-01-01

    The architecture of alcohol oxidase crystalloids occurring in vivo in the peroxisomes of methylotrophic yeasts was deduced from electron micrographs of similar crystals of the Hansenula polymorpha enzyme grown in vitro. Three characteristic views of the crystal are observed, as well as single layers

  4. Usefulness as a key parameter in the evaluation of accessibility and usability issues in architecture and the built environments

    DEFF Research Database (Denmark)

    Andersson, Jonas E

    In the Danish building code, the twin concept of accessibility and usability has an open interpretation on a comprehensive level of thinking, whereas the notions generate specific physical requirements on a detailed level when it comes to architecture and built environments. This study has been...... executed as a case study among 34 experienced professionals, active in the implementation of the twin concept in the built environments in order to facilitate for people with a cognitive or functional impairment. The research material has been assembled by the use of mini-questionnaires that have been...... synthesized with the informants’ recommendations of exemplary models of appropriately accessible and usable architecture and built environments. The aim of the present study is to position the twin concept of accessibility and usability with regard to their implementation in various types of architecture...

  5. CMOS nanoelectronics innovative devices, architectures, and applications

    CERN Document Server

    Collaert, Nadine

    2012-01-01

    This book covers one of the most important device architectures that have been widely researched to extend the transistor scaling: FinFET. Starting with theory, the book discusses the advantages and the integration challenges of this device architecture. It addresses in detail the topics such as high-density fin patterning, gate stack design, and source/drain engineering, which have been considered challenges for the integration of FinFETs. The book also addresses circuit-related aspects, including the impact of variability on SRAM design, ESD design, and high-T operation. It discusses a new d

  6. Development of water-soluble polyanionic carbosilane dendrimers as novel and highly potent topical anti-HIV-2 microbicides

    Science.gov (United States)

    Briz, Verónica; Sepúlveda-Crespo, Daniel; Diniz, Ana Rita; Borrego, Pedro; Rodes, Berta; de La Mata, Francisco Javier; Gómez, Rafael; Taveira, Nuno; Muñoz-Fernández, Mª Ángeles

    2015-08-01

    The development of topical microbicide formulations for vaginal delivery to prevent HIV-2 sexual transmission is urgently needed. Second- and third-generation polyanionic carbosilane dendrimers with a silicon atom core and 16 sulfonate (G2-S16), napthylsulfonate (G2-NS16) and sulphate (G3-Sh16) end-groups have shown potent and broad-spectrum anti-HIV-1 activity. However, their antiviral activity against HIV-2 and mode of action have not been probed. Cytotoxicity, anti-HIV-2, anti-sperm and antimicrobial activities of dendrimers were determined. Analysis of combined effects of triple combinations with tenofovir and raltegravir was performed by using CalcuSyn software. We also assessed the mode of antiviral action on the inhibition of HIV-2 infection through a panel of different in vitro antiviral assays: attachment, internalization in PBMCs, inactivation and cell-based fusion. Vaginal irritation and histological analysis in female BALB/c mice were evaluated. Our results suggest that G2-S16, G2-NS16 and G3-Sh16 exert anti-HIV-2 activity at an early stage of viral replication inactivating the virus, inhibiting cell-to-cell HIV-2 transmission, and blocking the binding of gp120 to CD4, and the HIV-2 entry. Triple combinations with tenofovir and raltegravir increased the anti-HIV-2 activity, consistent with synergistic interactions (CIwt: 0.33-0.66). No vaginal irritation was detected in BALB/c mice after two consecutive applications for 2 days with 3% G2-S16. Our results have clearly shown that G2-S16, G2-NS16 and G3-Sh16 have high potency against HIV-2 infection. The modes of action confirm their multifactorial and non-specific ability, suggesting that these dendrimers deserve further studies as potential candidate microbicides to prevent vaginal/rectal HIV-1/HIV-2 transmission in humans.

  7. Topical polyethylene glycol as a novel chemopreventive agent for oral cancer via targeting of epidermal growth factor response.

    Directory of Open Access Journals (Sweden)

    Ramesh K Wali

    Full Text Available Head and neck squamous cell carcinoma (HNSCC is a major cause of morbidity and mortality underscoring the need for safe and effective chemopreventive strategies. Targeting epidermal growth factor receptor (EGFR is attractive in that it is an early critical event in HNSCC pathogenesis. However, current agents lack efficacy or have unacceptable toxicity. Several groups have demonstrated that the over-the-counter medication, polyethylene glycol (PEG has remarkable chemopreventive efficacy against colon carcinogenesis. Importantly, we reported that this effect is mediated through EGFR internalization/degradation. In the current study, we investigated the chemopreventive efficacy of this agent against HNSCC, using both the well validated animal model 4-NQO (4-nitroquinoline 1-oxide rat model and cell culture with the human HNSCC cell line SCC-25. We demonstrated that daily topical application of 10% PEG-8000 in the oral cavity (tongue and cavity wall post 4NQO initiation resulted in a significant reduction in tumor burden (both, tumor size and tumors/tumor bearing rat without any evidence of toxicity. Immunohistochemical studies depicted decreased proliferation (number of Ki67-positive cells and reduced expression of EGFR and its downstream effectors cyclin D1 in the tongue mucosa of 4NQO-rats treated with PEG. We showed that EGFR was also markedly downregulated in SCC-25 cells by PEG-8000 with a concomitant induction of G1-S phase cell-cycle arrest, which was potentially mediated through upregulated p21(cip1/waf1. In conclusion, we demonstrate, for the first time, that PEG has promising efficacy and safety as a chemopreventive efficacy against oral carcinogenesis.

  8. Religious Architecture

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The main religions of ancient China were Buddhism,Taoism and Islam, of which Buddhism was the most widespread. As a result, Buddhist temples and towers are found all over China, and have become important components of the country's ancient architecture.

  9. Proteins with complex architecture as potential targets for drug design: a case study of Mycobacterium tuberculosis.

    Directory of Open Access Journals (Sweden)

    Bálint Mészáros

    2011-07-01

    Full Text Available Lengthy co-evolution of Homo sapiens and Mycobacterium tuberculosis, the main causative agent of tuberculosis, resulted in a dramatically successful pathogen species that presents considerable challenge for modern medicine. The continuous and ever increasing appearance of multi-drug resistant mycobacteria necessitates the identification of novel drug targets and drugs with new mechanisms of action. However, further insights are needed to establish automated protocols for target selection based on the available complete genome sequences. In the present study, we perform complete proteome level comparisons between M. tuberculosis, mycobacteria, other prokaryotes and available eukaryotes based on protein domains, local sequence similarities and protein disorder. We show that the enrichment of certain domains in the genome can indicate an important function specific to M. tuberculosis. We identified two families, termed pkn and PE/PPE that stand out in this respect. The common property of these two protein families is a complex domain organization that combines species-specific regions, commonly occurring domains and disordered segments. Besides highlighting promising novel drug target candidates in M. tuberculosis, the presented analysis can also be viewed as a general protocol to identify proteins involved in species-specific functions in a given organism. We conclude that target selection protocols should be extended to include proteins with complex domain architectures instead of focusing on sequentially unique and essential proteins only.

  10. Exporting Humanist Architecture

    DEFF Research Database (Denmark)

    Nielsen, Tom

    2016-01-01

    values and ethical stands involved in the export of Danish Architecture. Abstract: Danish architecture has, in a sense, been driven by an unwritten contract between the architects and the democratic state and its institutions. This contract may be viewed as an ethos – an architectural tradition...... with inherent aesthetic and moral values. Today, however, Danish architecture is also an export commodity. That raises questions, which should be debated as openly as possible. What does it mean for architecture and architects to practice in cultures and under political systems that do not use architecture...... as a way of generating humanism, freedom or equality? The essay outlines the background story, identifies a number of positions in relation to architecture exports and discusses some of the dilemmas that arise when Danish architecture is seen in an export perspective....

  11. Polymer-nanocomposite brush-like architectures as an all-solid electrolyte matrix.

    Science.gov (United States)

    Gowneni, Soujanya; Ramanjaneyulu, Kota; Basak, Pratyay

    2014-11-25

    Herein, we report on polymer-nanocomposites with brush-like architectures and evaluate their feasibility as an all-solid electrolyte matrix supporting Li(+)-ion conduction. Showcased as a first example in the domain of electrolyte research, the study probes several key factors, such as (i) core morphology, (ii) surface modifiers/functionality, (iii) grafting length, and (iv) density of the brushes, and determines their role on the overall electrochemical properties of these nanostructured organic-inorganic hybrids. Nanostructured titania was synthesized via wet-chemical approaches using either controlled hydrolysis or hydrothermal methods. Exercising suitable control on reaction parameters led to well-defined morphologies/phases, such as nanoparticles, nanospindles, nanourchins, nanorods or nanotubes, in either anatase, rutile or mixed forms. Covalent anchoring on titania nanostructures was achieved using dopamine, gallic acid and glycerol as small organic moieties. A one-pot process of priming the available surface functional groups postmodification with isocyanate chemistry was followed by grafting polyethylene glycol monomethyl ethers of desired chain lengths. Finally, complexation with lithium salt yielded electrolyte compositions where the ethylene oxide (EO) fractions aid in ion-solvation with ease. The synthesized materials were characterized in detail employing XRD, TEM, DRS-UV, FTIR, micro-Raman, TG-DTA and DSC at each stage to confirm the products and ascertain the physicochemical properties. Comprehensive evaluation using temperature-step electrochemical impedance spectroscopy (EIS) of these brush-like nanocomposites provided crucial leads toward establishing a plausible physical model for the system and understanding the mechanism of ion transport in these all-solid matrices. The preliminary results on ionic conductivity (σ) obtained for some of the compositions are estimated to be within the range of ∼10(-4) to 10(-5) S cm(-1) in the temperature

  12. Characters and Topical Diversity

    DEFF Research Database (Denmark)

    Eriksson, Rune

    2014-01-01

    The purpose of this article is to contribute to our understanding of the difference between the bestseller and the non-bestseller in nonfiction. It is noticed that many bestsellers in nonfiction belongs to the sub-genre of creative nonfiction, but also that the topics in this kind of literature...... is largely ignored by the critics. Thus, the article tests how topics may work in creative nonfiction. Two Danish bestsellers belonging to the genre, Frank’s Mit smukke genom ( My Beautiful Genome), about genomics, and Buk-Swienty’s Slagtebænk Dybbøl ( ‘Slaughter-bench Dybbøl’), a history book, are chosen...... as cases and analysed using a slightly modified motif model by Johansen. The result is that in both books the main topic is treated from a double perspective, but also that six out of seven secondary topics, or motifs, are treated as well. It is concluded that also in a topical sense creative nonfiction...

  13. ACCESS Mars: A Mission Architecture for an initial settlement on Mars; using caves as habitation

    Science.gov (United States)

    Perez-Poch, Antoni; Gallardo, Beatriz; Laufer, Ren; Zavaleta, Jhony; Davila, Alfonso; de Carufel, Guy; Antonakopoulos, Konstantinos; Husseini, A. Al; Alvarez Sánchez, L.; Antonakopoulos, K.; Apeldoorn, J.; Ashford, K., Jr.; Atabay, D.; Barrios, I.; Baydaroglu, Y.; Bennell, K. M.; Chen, J.; Chen, X.; Cormier, D.; Crowley, P.; de Carufel, G.; Deper, B.; Drube, L.; Duffy, P.; Edwards, P.; Gutiérrez Fernandez, E.; Haider, O.; Kumar, G.; Henselowsky, C.; Hirano, D.; Hirmer, T.; Hogan, B.; Albalat, A. Jaime; Jens, E.; Jivenescu, I.; Jojaghaian, A.; Kerrigan, M.; Kodachi, Y.; Langston, S.; Macintosh, R.; Miguélez, X.; Panek, N.; Pegg, C.; Peldszus, R.; Peng, X.; Perez-Poch, A.; Perron, A.; Qiu, J.; Renten, P.; Ricardo, J.; Saraceno, T.; Sauceda, F.; Shaghaghi Varzeghani, A.; Shimmin, R.; Solaz, R.; Solé, A.; Suresh, E. R.; Mar Vaquero Escribano, T.; Vargas Muñoz, M.; Vaujour, P. D.; Zeile, D. Veilette, Y. Winetraub, O.

    This paper summarizes a team project report produced during the Summer Space Program of the International Space University, held at Nasa-Ames Research Center (CA, USA) by 56 students from 15 countries. Chair of the team project was Rene Laufer. Facilitators were Alfonso Davila and Jhonny Zavaleta, and teacher associate supporting the team was Beatriz Gallardo. The human race has evolved, grown and expanded through the exploration of Earth. After initial steps on the Moon, our next challenge is to explore the solar system. Mars shows potential for both scientific discovery and future human settlement, and therefore represents a prime candidate for the next leap of human exploration. Such a bold endeavor will be a driver for an unprecedented worldwide cooperative effort and the catalyst for a new era of international, intercultural and interdisciplinary human relations. Scientific and technological progress will also accelerate as mankind is ushered into a new era of space exploration. Currently proposed Mars missions have identified a number of challenges such as high levels of radiation, harsh climate and limited launch windows. Recently discovered lava tubes on Mars present potential solutions to some of these issues, but raise a variety of intriguing new challenges. This paper reviews existing reference missions and identifies areas of further research essential for adapting mission architectures to utilize caves. Different mission scenarios are proposed and analyzed, with a number of different recommendations given. An analysis of the feasibility of using Martian lava tubes as habitation is given in another paper by the same authors at COSPAR 2010 F34 Technical Session. Literature suggests a low radiation environment within Martian caves, allowing for extended duration missions. The ACCESS Mars Team concludes that the use of lava tubes as human habitats will be more beneficial for human Mars exploration than currently proposed surface solutions.

  14. Concept mapping as a method to teach an evidence-based educated medical topic: a comparative study in medical students

    OpenAIRE

    Saeidifard, Farzane; Heidari, Kazem; Foroughi, Moein; Soltani, Akbar

    2014-01-01

    Background The objective of this study was to compare concept mapping with lecture-based method in teaching of evidence based educated topic to medical students. Methods This randomized controlled trial was carried out on medical students during sixth year of 7-year MD curriculum clerkship phase. Cluster randomization was used to divide students into intervention and control groups. Both groups, at the beginning, were taught “Diabetic Ketoacidosis” (DKA) using evidence-based tool named Critic...

  15. Metronidazole Topical

    Science.gov (United States)

    ... anticoagulants ('blood thinners') such as warfarin (Coumadin) and vitamins.tell your doctor if you have or have ever had a central nervous system disease, liver or blood disease, or Crohn's disease.tell your doctor if you are pregnant, ...

  16. Solid Lipid Nanoparticles Loaded with Retinoic Acid and Lauric Acid as an Alternative for Topical Treatment of Acne Vulgaris.

    Science.gov (United States)

    Silva, Elton Luiz; Carneiro, Guilherme; De Araújo, Lidiane Advíncula; Trindade, Mariana de Jesus Vaz; Yoshida, Maria Irene; Oréfice, Rodrigo Lambert; Farias, Luis de Macêdo; De Carvalho, Maria Auxiliadora Roque; Dos Santos, Simone Gonçalves; Goulart, Gisele Assis Castro; Alves, Ricardo José; Ferreira, Lucas Antônio Miranda

    2015-01-01

    Topical therapy is the first choice for the treatment of mild to moderate acne and all-trans retinoic acid is one of the most used drugs. The combination of retinoids and antimicrobials is an innovative approach for acne therapy. Recently, lauric acid, a saturated fatty acid, has shown strong antimicrobial activity against Propionibacterium acnes. However, topical application of retinoic acid is followed by high incidence of side-effects, including erythema and irritation. Solid lipid nanoparticles represent an alternative to overcome these side-effects. This work aims to develop solid lipid nanoparticles loaded with retinoic acid and lauric acid and evaluate their antibacterial activity. The influence of lipophilic stearylamine on the characteristics of solid lipid nanoparticles was investigated. Solid lipid nanoparticles were characterized for size, zeta potential, encapsulation efficiency, differential scanning calorimetry and X-ray diffraction. The in vitro inhibitory activity of retinoic acid-lauric acid-loaded solid lipid nanoparticles was evaluated against Propionibacterium acnes, Staphylococcus aureus and Staphylococcus epidermidis. High encapsulation efficiency was obtained at initial time (94 ± 7% and 100 ± 4% for retinoic acid and lauric acid, respectively) and it was demonstrated that lauric acid-loaded-solid lipid nanoparticles provided the incorporation of retinoic acid. However, the presence of stearylamine is necessary to ensure stability of encapsulation. Moreover, retinoic acid-lauric acid-loaded solid lipid nanoparticles showed growth inhibitory activity against Staphylococcus epidermidis, Propionibacterium acnes and Staphylococcus aureus, representing an interesting alternative for the topical therapy of acne vulgaris.

  17. EVALUATING AND REFINING THE ‘ENTERPRISE ARCHITECTURE AS STRATEGY’ APPROACH AND ARTEFACTS

    Directory of Open Access Journals (Sweden)

    M. De Vries

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: Enterprise Architecture (EA is a new discipline that has emerged from the need to create a holistic view of an enterprise, and thereby to discover business/IT integration and alignment opportunities across enterprise structures. Previous EA value propositions that merely focus on IT cost reductions will no longer convince management to invest in EA. Today, EA should enable business strategy in the organisation to create value. This resides in the ability to do enterprise optimisation through process standardisation and integration. In order to do this, a new approach is required to integrate EA into the strategy planning process of the organisation.
    This article explores the use of three key artefacts – operating models, core diagrams, and an operating maturity assessment as defined by Ross, Weill & Robertson [1] – as the basis of this new approach. Action research is applied to a research group to obtain qualitative feedback on the practicality of the artefacts.

    AFRIKAANSE OPSOMMING: Ondernemingsargitektuur (OA is ’n nuwe dissipline wat ontstaan het uit die behoefte om ’n holistiese perspektief van ’n onderneming te skep om sodoende besigheid/IT-integrasie en - belyningsgeleenthede regoor ondernemingstrukture te ontdek. Vorige OA waardeaanbiedings wat hoofsaaklik gefokus het op IT kostebesparings sal bestuur nie meer kan oorreed om in OA te belê nie. Vandag behoort OA bevoegdheid te gee aan ondernemingstrategie om werklik waarde te skep. Hierdie bevoegdheid lê gesetel in ondernemingsoptimering deur middel van prosesstandaardisasie en -integrasie. ’n Nuwe benadering word benodig ten einde OA te integreer met die strategiese beplanningsproses van die organisasie.
    Hierdie artikel ondersoek die gebruik van drie artefakte – operasionele modelle, kerndiagramme, en operasionele volwassenheidsassessering soos gedefinieer deur Ross, Weill & Robertson [1] – as die basis van hierdie nuwe benadering

  18. PERCEPTION AND STYLISTIC EXPRESSION OF ANITKABIR AS AN ARCHITECTURAL OBJECT BY PRIMARY SCHOOL CHILDREN

    Directory of Open Access Journals (Sweden)

    Fadimana SELVİ

    2012-08-01

    Full Text Available This study was shaped and developed regarding the existence of a relationship between spatial perception and lines as observed in primary school children. Perception, receiving a variety of approaches from different disciplines, is assessed in our study through a model based on what portion of the things remembered by thechild is spatial and what are the remembered parts or features of a familiar space. The study investigates Anıtkabir as a well-known architectural object which carries very distinct structures in terms of linear expression. The study aims at determining to what extent the formal expression of the space remembered by the child aftervisual perception through drawing matches the artistic development stages; schematic, dawning realism and pseudorealism. A literature review was carried out in order to constitute a basis for the fieldwork encompassing children from schematic, dawning realism and pseudorealism stages. The second step has been providing theoretical information concerning Anıtkabir to the student groups from Başyayla Primary Education School attending to 4th (schematic, 6th (dawningrealism and 8th (pseudorealism grades using various common methods (visits, media, teaching tools, etc. during 2009-2010 Education Year Fall Semester. Later the students were asked to put their perceptions in practice and the results were interpreted within the target parameters. This study asserts that the formation of space in memory as a result of visual perception are coded in view of the phaseoccupied by the child, personal differences, different styles of perception and spatial experiences and the drawings support the features of the phase occupied by the child.

  19. Automatic Labelling of Topics with Neural Embeddings

    OpenAIRE

    Bhatia, Shraey; Lau, Jey Han; Baldwin, Timothy

    2016-01-01

    Topics generated by topic models are typically represented as list of terms. To reduce the cognitive overhead of interpreting these topics for end-users, we propose labelling a topic with a succinct phrase that summarises its theme or idea. Using Wikipedia document titles as label candidates, we compute neural embeddings for documents and words to select the most relevant labels for topics. Compared to a state-of-the-art topic labelling system, our methodology is simpler, more efficient, and ...

  20. Theories of minimalism in architecture: When prologue becomes palimpsest

    Directory of Open Access Journals (Sweden)

    Stevanović Vladimir

    2014-01-01

    Full Text Available This paper examines the modus and conditions of constituting and establishing architectural discourse on minimalism. One of the key topics in this discourse are historical line of development and the analysis of theoretical influences, which comprise connections of recent minimalism with the theorizations of various minimal, architectural and artistic, forms and concepts from the past. The paper shall particularly discuss those theoretical relations which, in a unitary way, link minimalism in architecture with its artistic nominal counterpart - minimal art. These are the relations founded on the basis of interpretative models on self-referentiality, phenomenological experience and contextualism, which are superficialy observed, common to both, artistic and architectural, minimalist discourses. It seems that in this constellation certain relations on the historical line of minimalism in architecture are questionable, while some other are overlooked. Precisely, posmodern fundamentalism is the architectural direction: 1 in which these three interpretations also existed; 2 from which architectural theorists retroactively appropriated many architects proclaiming them minimalists; 3 which establish identical relations with modern and postmodern theoretical and socio-historical contexts, as well as it will be done in minimalism. In spite of this, theoretical field of postmodern fundamentalism is surprisingly neglected in the discourse of minimalism in architecture. Instead of understanding postmodern fundamentalism as a kind of prologue to minimalism in architecture, it becomes an erased palimpsest over whom the different history of minimalism is rewriting, the history in which minimal art which occupies a central place.

  1. International collaboration and partnering in the supply chain as business opportunities for architectural firms

    NARCIS (Netherlands)

    Bos-de Vos, M.; Lieftink, B.; Volker, L.; Wamelink, J.W.F.

    2014-01-01

    Due to a shift towards market driven concepts, a risk allocation from the demand side to the supply side and the increasing competition with other skilled actors in the value chain, architectural firms have to adapt quickly to stay competitive. They need to innovate not only their products and servi

  2. Architectural slicing

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Hansen, Klaus Marius

    2013-01-01

    a system and a slicing criterion, architectural slicing produces an architectural prototype that contain the elements in the architecture that are dependent on the ele- ments in the slicing criterion. Furthermore, we present an initial design and implementation of an architectural slicer for Java.......Architectural prototyping is a widely used practice, con- cerned with taking architectural decisions through experiments with light- weight implementations. However, many architectural decisions are only taken when systems are already (partially) implemented. This is prob- lematic in the context...... of architectural prototyping since experiments with full systems are complex and expensive and thus architectural learn- ing is hindered. In this paper, we propose a novel technique for harvest- ing architectural prototypes from existing systems, \\architectural slic- ing", based on dynamic program slicing. Given...

  3. Topical ketoprofen patch.

    Science.gov (United States)

    Mazières, Bernard

    2005-01-01

    Although oral nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in the treatment of a variety of acute and chronic pain conditions, their use may be associated with serious systemic adverse effects, particularly gastrointestinal disorders. In order to minimise the incidence of systemic events related to such agents, topical NSAIDs have been developed. Topical NSAIDs, applied as gels, creams or sprays, penetrate the skin, subcutaneous fatty tissue and muscle in amounts that are sufficient to exert a therapeutic effect on peripheral and central mechanisms in the absence of high plasma concentrations. Data indicate that topical NSAIDs are effective at relieving pain in a number of acute and chronic pain indications. This review article discusses the pharmacokinetics, efficacy and tolerability of a new formulation of ketoprofen available as a topical patch. The topical patch containing ketoprofen 100mg as the active principle has been developed using a novel delivery system that dispenses therapeutic doses of the drug directly to the site of injury. Pharmacokinetic data indicate that although plasma levels of ketoprofen are higher when the drug is administered as a patch versus a gel, the total systemic bioavailability of ketoprofen 100 mg administered via a patch is no more than 10% of that reported for ketoprofen 100 mg administered orally. Because the patch facilitates ketoprofen delivery over a 24-hour period, the drug remains continually present in the tissue subjacent to the site of application. High tissue but low plasma ketoprofen concentrations mean that while tissue concentrations are high enough to exert a therapeutic effect, plasma concentrations remain low enough to not result in systemic adverse events caused by elevated serum NSAID levels. Phase III clinical trials in patients with non-articular rheumatism and traumatic painful soft tissue injuries showed that the topical ketoprofen patch was significantly more effective than placebo at

  4. Data-Centric Enterprise Architecture

    OpenAIRE

    Zeinab Rajabi; Maryam Nooraei Abade

    2012-01-01

    Enterprises choose Enterprise Architecture (EA) solution, in order to overcome dynamic business challenges and in coordinate various enterprise elements. In this article, a solution is suggested for the Enterprise Architecture development. The solution focuses on architecture data in the Enterprise Architecture development process. Data-centric architecture approach is preferred product-centric architecture approach. We suggest using Enterprise Ontology (EO) as context for collecting architec...

  5. Land use and cover change as an overarching topic in the Dutch National Research Programme on Global Air Pollution and Climate Change : issues for implementation

    NARCIS (Netherlands)

    Fresco, L.O.; Berg, van den M.M.; Zeijl-Rozema, van A.E.

    1996-01-01

    The integration study 'Land Use and Cover Change as an overarching topic in the Dutch National Research Programme on Global Air Pollution and Climate Change (NRP)' aims at identifying research fields in which the NRP can contribute most effectively to the international scientific know-how

  6. Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products - part 1: Achillea millefolium-Curcuma longa.

    Science.gov (United States)

    Calapai, Gioacchino; Miroddi, Marco; Minciullo, Paola L; Caputi, Achille P; Gangemi, Sebastiano; Schmidt, Richard J

    2014-07-01

    This review focuses on contact dermatitis as an adverse effect of a selection of topically used herbal medicinal products for which the European Medicines Agency has completed an evaluation up to the end of November 2013 and for which a Community herbal monograph has been produced. Part 1: Achillea millefolium L.-Curcuma longa L.

  7. Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products - part 2: Echinacea purpurea-Lavandula angustifolia.

    Science.gov (United States)

    Gangemi, Sebastiano; Minciullo, Paola L; Miroddi, Marco; Chinou, Ioanna; Calapai, Gioacchino; Schmidt, Richard J

    2015-04-01

    This review focuses on contact dermatitis as an adverse effect of a selection of topically used herbal medicinal products for which the European Medicines Agency has completed an evaluation up to the end of November 2013 and for which a Community herbal monograph has been produced. Part 2: Echinacea purpurea Moench-Lavandula angustifolia Mill.

  8. Selected topics in magnetism

    CERN Document Server

    Gupta, L C

    1993-01-01

    Part of the ""Frontiers in Solid State Sciences"" series, this volume presents essays on such topics as spin fluctuations in Heisenberg magnets, quenching of spin fluctuations by high magnetic fields, and kondo effect and heavy fermions in rare earths amongst others.

  9. Transportation: Topic Paper E.

    Science.gov (United States)

    National Council on the Handicapped, Washington, DC.

    As one of a series of topic papers assessing federal laws and programs affecting persons with disabilities, this paper reviews the issue of transportation services. In the area of urban mass transit, four relevant pieces of legislation and public transportation accessibility regulations are cited, and cost issues are explored. Paratransit systems,…

  10. A prospective comparison of topical feracrylum citrate versus adrenaline as haemostatic agent in hypospadias surgery in children

    Directory of Open Access Journals (Sweden)

    Ashok Kumar Laddha

    2014-01-01

    Full Text Available Background: A comparative study of topical feracrylum citrate versus adrenaline to minimise haemorrhage-related complications in paediatric hypospadiac patients. Patients and Methods: A total of 108 consecutive paediatric hypospadiac patients (48 in the study group and 60 control - random allocation were studied. In the study group, 1% feracrylum citrate solution was used and adrenaline (1:100,000 in controls. Results: Among the study group, average number of blood-soaked gauge pieces were 2.95/patient, correlating with average intraoperative blood loss of 14.74 ml. In controls, average blood-soaked gauge pieces were 4.83/patient corresponding to an average blood loss of 24.13 ml. The average amount of blood loss during surgery in the <5 years was 13.70 ml/patient in the feracrylum group, while the same in the adrenaline group was 23.45 ml. Average duration of surgery was 79 min in the study group, while the same in controls was 94 min/patient. Average number of cauterisations was 0.255/patient in the study group and 0.583/patient among controls. Postoperative haematoma was seen in 8% study group compared with 18% controls. Wound oedema appeared in 4.17% study group and 11.67% controls. Postoperative complications were higher among controls. Conclusions: Feracrylum is more efficient and safer topical haemostatic agent than adrenaline. It reduced the frequency of cauterisation and tissue damage, intraoperative blood loss, and postoperative complications.

  11. Discovering health topics in social media using topic models.

    Directory of Open Access Journals (Sweden)

    Michael J Paul

    Full Text Available By aggregating self-reported health statuses across millions of users, we seek to characterize the variety of health information discussed in Twitter. We describe a topic modeling framework for discovering health topics in Twitter, a social media website. This is an exploratory approach with the goal of understanding what health topics are commonly discussed in social media. This paper describes in detail a statistical topic model created for this purpose, the Ailment Topic Aspect Model (ATAM, as well as our system for filtering general Twitter data based on health keywords and supervised classification. We show how ATAM and other topic models can automatically infer health topics in 144 million Twitter messages from 2011 to 2013. ATAM discovered 13 coherent clusters of Twitter messages, some of which correlate with seasonal influenza (r = 0.689 and allergies (r = 0.810 temporal surveillance data, as well as exercise (r =  .534 and obesity (r =  -.631 related geographic survey data in the United States. These results demonstrate that it is possible to automatically discover topics that attain statistically significant correlations with ground truth data, despite using minimal human supervision and no historical data to train the model, in contrast to prior work. Additionally, these results demonstrate that a single general-purpose model can identify many different health topics in social media.

  12. For a choral architecture, as a contamination between disciplines and cultures

    Directory of Open Access Journals (Sweden)

    Edoardo Narne

    2015-11-01

    Full Text Available The profession of the architect today should redefined where it loses the image of the anachronistic artist-architect capable of solving the complex problems of contemporary multiethnic societies that manifest mostly in suburbs by using “their genius”. It will become increasingly more important that collective design, and not individual approaches, embrace not only professionals but also expand to new disciplines: architecture and design, fine arts and sculpture. Obviously, architecture is not an object to be observed, but a field of energy and relationships within which to learn to move. The privileged nature of the designer will be the readiness to learn to from other discipline and cultures, in a world where distances contract and everything seems to be only a step away.

  13. Building services cabinets as teaching material in a degree in architecture

    Science.gov (United States)

    Martín-Gómez, César; Zapata, Omayra; Zuazua, Amaia; Villanueva, Sonia; Olaizola, Paula

    2014-03-01

    The aim of this innovative educational project is to encourage students' interest in one of the most underrated fields of architecture: building services. With this material students interact with real elements and thereby understand the relationship between facilities and the building. A set of three small technical cabinets is planned. They allow for comfortable use and movement inside the building, need minimum maintenance and are easily stored. The result is an alternative concept of a mobile laboratory called a 'technical cabinet', made up of three mobile units for fire safety, electricity and the heating/cooling system. The design, content and learning systems of the cabinets confirmed the validity of the initial concept during the first year of use. A protocol has also been developed for each of the technical cabinets so that the teaching experience may be of use in other Schools of Architecture.

  14. Theories of minimalism in architecture: Post scriptum

    Directory of Open Access Journals (Sweden)

    Stevanović Vladimir

    2012-01-01

    Full Text Available Owing to the period of intensive development in the last decade of XX century, architectural phenomenon called Minimalism in Architecture was remembered as the Style of the Nineties, which is characterized, morphologically speaking, by simplicity and formal reduction. Simultaneously with its development in practice, on a theoretical level several dominant interpretative models were able to establish themselves. The new millennium and time distance bring new problems; therefore this paper represents a discussion on specific theorization related to Minimalism in Architecture that can bear the designation of post scriptum, because their development starts after the constitutional period of architectural minimalist discourse. In XXI century theories, the problem of definition of minimalism remains important topic, approached by theorists through resolving on the axis: Modernism - Minimal Art - Postmodernism - Minimalism in Architecture. With regard to this, analyzed texts can be categorized in two groups: 1 texts of affirmative nature and historical-associative approach in which minimalism is identified with anything that is simple and reduced, in an idealizing manner, relied mostly on the existing hypotheses; 2 critically oriented texts, in which authors reconsider adequacy of the very term 'minimalism' in the context of architecture and take a metacritical attitude towards previous texts.

  15. Sculpture Versus Architecture?

    Directory of Open Access Journals (Sweden)

    Alexander Rappaport

    2007-07-01

    Full Text Available Many critics consider Richard Serra the leading sculptor of the 20th century. He is famous not only for inventing something new in sculpture (abstract sculpture compositions existed before him, having been opened by constructivist vanguard of the beginning of the 20th century. Material selections by Vladimir Tatlin and sculptures by Osip Tsadkin, as well as compositions by Henry Moor appeared before Serra. Serra is famous for transferring his works' accent from the works as they are, which could be installed in any place, to their environment. That is he saw in the sculpture a key to understanding the urban space. His crude metal sheets and profiles, rectangular and curvilinear, exceeding regular scale of sculpture, come closer to architecture. Richard Serra places them near architectural constructions as checkpoints of intermediate scale category of space located between so-called «street furniture» – lamp posts, stalls, fountains and benches – and buildings, especially huge modern ones.But the matter is not only in the scale. Serra's sculptures are not only abstract compositions that harmoniously add to the space with their spacious scale. They have some mystery, some implicit sense appearing before a pedestrian as an enigma. Their mystique opposes both street furniture and architecture. But first of all it opposes the historical sculpture with its enigma always overshadowed by historical or biographical topic. Krylov's sculpture in the Summer Garden or Minin and Pozharsky's monument on the Red Square do not strike us, because we know that those monuments are erected IN COMMEMORATION of prominent people, as fellow citizens' tribute to their great contribution to the national history. But the crude metal sheets welded at different angles – what are they for? Who needs them?As an art critic, Edward Goldman, said, fame came to Richard Serra in 1989, when the sculpture composition Tilted Arc erected eight years before it was demolished by

  16. Architectural Theatricality

    DEFF Research Database (Denmark)

    Tvedebrink, Tenna Doktor Olsen

    putting an emphasis on architecture as unified scenery guided by the four motives hearth, enclosure, dressing and context. This theoretical framework draws on the Gastronomic Analogy put forth by James Fergusson in 1862 and an interpretation of the writings of the 19th century architect Gottfried Semper...... with the material appearance of objects, but also the imaginary world of dreams and memories which are concealed with the communicative significance of intentions when designing the future super hospitals....

  17. Architectural Theatricality

    DEFF Research Database (Denmark)

    Tvedebrink, Tenna Doktor Olsen; Fisker, Anna Marie; Kirkegaard, Poul Henning

    2013-01-01

    is known for his writings on theatricality, understood as a holistic design approach emphasizing the contextual, cultural, ritual and social meanings rooted in architecture. Relative hereto, the International Food Design Society recently argued, in a similar holistic manner, that the methodology used......’ is an overlooked element in hospital eating environments today, and further point at how Semper’s discourse on theatricality can be used to add a more nuanced perspective to future hospitality studies....

  18. Facile fabrication of superhydrophobic flower-like polyaniline architectures by using valine as a dopant in polymerization

    Science.gov (United States)

    Sun, Jun; Bi, Hong

    2012-03-01

    A facile method was developed to fabricate superhydrophobic, flower-like polyanline (PANI) architectures with hierarchical nanostructures by adding valine in polymerization as a dopant. The water contact angle of the prepared PANI film was measured to be 155.3°, and the hydrophobic surface of the PANI architectures can be tuned easily by varying the polymerization time as well as valine doping quantity. It is believed that valine plays an important role in not only growth of the hierarchical PANI structures but also formation of the superhydrophobic surface, for it provides functional groups such as sbnd COOH, sbnd NH2 and a hydrophobic terminal group which may further increase intra-/inter-molecular interactions including hydrogen bonding, π-π stacking and hydrophobic properties. Similar flower-like PANI architectures have been prepared successfully by employing other amino acids such as threonine, proline and arginine. This method makes it possible for widespread applications of superhydrophobic PANI film due to its simplicity and practicability.

  19. THE DESIGN OF MOSQUES AS COMMUNITY DEVELOPMENT CENTERS FROM THE PERSPECTIVE OF THE SUNNA AND WRIGHT’S ORGANIC ARCHITECTURE

    Directory of Open Access Journals (Sweden)

    Mohamad Tajuddin Mohamad Rasdi, Nangkula Utaberta

    2012-03-01

    Full Text Available The main purpose of this paper is to present an alternative approach to mosque design with particular reference to the context of Malaysia and the Malay World or the Nusantara. The paper contains four main parts. The first part examines the problem of mosque architectural interpretation from the perspective of Western architectural historiography. The main problems highlighted are those which pertain to the idea of ‘architecture’, ‘religious architecture’, relevance of the body of knowledge known as the ‘Hadith’ and lastly the specific historical-political agenda of some traditional mosques. The second part of the paper expounds briefly a reinterpretation of the hadith in arguing that the mosque approaches more as a community development complex than that as a mere house of rituals. The third part of the paper examines Wright’s Organic Architecture with specific reference to the design of the Unity Church and a few other buildings as containing some important lessons of mosque designs from the perspective of the Sunnah. The final part of the paper uses the principles discussed to criticize the Putra Mosque and the Masjid Negara.  

  20. The Spanish Modernity as the Narration of the Peripheral. Architectural Laboratory and Urban Visions in the Distant Iberian South

    OpenAIRE

    2014-01-01

    The evaluation and dissemination of Spanish Modern architecture has been conditioned by its peripheral condition that, similarto all those works external to the central European phenomenon, has marked the definition of its production. In the light of thecultural crisis that the Western World has been experiencing since the Sixties, critics such as Ignasi de Solà-Morales considerthat this interpretation of the architectonic panorama of a dominating centre and a dominated periphery has been ove...

  1. Lunar architecture and urbanism

    Science.gov (United States)

    Sherwood, Brent

    1992-01-01

    Human civilization and architecture have defined each other for over 5000 years on Earth. Even in the novel environment of space, persistent issues of human urbanism will eclipse, within a historically short time, the technical challenges of space settlement that dominate our current view. By adding modern topics in space engineering, planetology, life support, human factors, material invention, and conservation to their already renaissance array of expertise, urban designers can responsibly apply ancient, proven standards to the exciting new opportunities afforded by space. Inescapable facts about the Moon set real boundaries within which tenable lunar urbanism and its component architecture must eventually develop.

  2. Three-dimensional spider-web architecture assembled from Na₂Ti₃O₇ nanotubes as a high performance anode for a sodium-ion battery.

    Science.gov (United States)

    Zhang, Yuping; Guo, Lin; Yang, Shihe

    2014-11-21

    A Na2Ti3O7 nanotube-assembled three-dimensional spider-web architecture is synthesized using a hydrothermal method. The self-similar network architecture exhibits an excellent performance as an anode for a room temperature sodium ion battery without any additives (e.g. binder, conducting agent) for the first time.

  3. Architectural Trend of the Epoch: Architect Chernyshev as a bright representative of the Siberian Modern

    Directory of Open Access Journals (Sweden)

    Olga Uspenskaya

    2016-10-01

    Full Text Available The article is about a bright representative of the Siberian Modern, Leonid Alexandrovich Chernyshev, who made a great contribution to the development of Krasnoyarsk city architecture. On the initiative of the Board of the Krasnoyarsk regional organization of the Union of Architects of Russia the year 2015 in Krasnoyarsk was announced the Year of the Architect Chernyshev to commemorate his 140th anniversary. During the anniversary year several important events will be held to demonstrate the architect’s creative heritage both to architects and citizens.

  4. The relationship between nanoscale architecture and function in photovoltaic multichromophoric arrays as visualized by Kelvin probe force microscopy.

    Science.gov (United States)

    Palermo, Vincenzo; Otten, Matthijs B J; Liscio, Andrea; Schwartz, Erik; de Witte, Pieter A J; Castriciano, Maria Angela; Wienk, Martijn M; Nolde, Fabian; De Luca, Giovanna; Cornelissen, Jeroen J L M; Janssen, René A J; Müllen, Klaus; Rowan, Alan E; Nolte, Roeland J M; Samorì, Paolo

    2008-11-05

    The physicochemical properties of organic (multi)component films for optoelectronic applications depend on both the mesoscopic and nanoscale architectures within the semiconducting material. Two main classes of semiconducting materials are commonly used: polymers and (liquid) crystals of small aromatic molecules. Whereas polymers (e.g., polyphenylenevinylenes and polythiophenes) are easy to process in solution in thin and uniform layers, small molecules can form highly defined (liquid) crystals featuring high charge mobilities. Herein, we combine the two material types by employing structurally well-defined polyisocyanopeptide polymers as scaffolds to precisely arrange thousands of electron-accepting molecules, namely, perylenebis(dicarboximides) (PDIs), in defined chromophoric wires with lengths of hundreds of nanometers. The polymer backbone enforces high control over the spatial location of PDI dyes, favoring both enhanced exciton and charge transfer. When blended with an electron-donor system such as regioregular poly(3-hexylthiophene), this polymeric PDI shows a relative improvement in charge generation and diffusion with respect to monomeric, aggregated PDI. In order to correlate this enhanced behavior with respect to the architecture, atomic force microscopy investigations on the mixtures were carried out. These studies revealed that the two polymers form interpenetrated bundles having a nanophase-segregated character and featuring a high density of contact points between the two different phases. In order to visualize the relationship between the architecture and the photovoltaic efficiency, Kelvin probe force microscopy measurements were carried out on submonolayer-thick films. This technique allowed for the first time the direct visualization of the photovoltaic activity occurring in such a nanoscale phase-segregated ultrathin film with true nanoscale spatial resolution, thus making possible a study of the correlation between function and architecture

  5. Detail in architecture: Between arts

    Directory of Open Access Journals (Sweden)

    Dulencin Juraj

    2016-06-01

    Full Text Available Architectural detail represents an important part of architecture. Not only can it be used as an identifier of a specific building but at the same time enhances the experience of the realized project. Within it lie the signs of a great architect and clues to understanding his or her way of thinking. It is therefore the central topic of a seminar offered to architecture students at the Brno University of Technology. During the course of the semester-long class the students acquaint themselves with atypical architectural details of domestic and international architects by learning to read them, understand them and subsequently draw them by creating architectural blueprints. In other words, by general analysis of a detail the students learn theoretical thinking of its architect who, depending on the nature of the design, had to incorporate a variety of techniques and crafts. Students apply this analytical part to their own architectural detail design. The methodology of the seminar consists of experiential learning by project management and is complemented by a series of lectures discussing a diversity of details as well as materials and technologies required to implement it. The architectural detail design is also part of students’ bachelors thesis, therefore, the realistic nature of their blueprints can be verified in the production process of its physical counterpart. Based on their own documentation the students choose the most suitable manufacturing process whether it is supplied by a specific technology or a craftsman. Students actively participate in the production and correct their design proposals in real scale with the actual material. A student, as a future architect, stands somewhere between a client and an artisan, materializes his or her idea and adjusts the manufacturing process so that the final detail fulfills aesthetic consistency and is in harmony with its initial concept. One of the very important aspects of the design is its

  6. N-pyridinyl-indole-3-(alkyl)carboxamides and derivatives as potential systemic and topical inflammation inhibitors.

    Science.gov (United States)

    Duflos, M; Nourrisson, M R; Brelet, J; Courant, J; LeBaut, G; Grimaud, N; Petit, J Y

    2001-06-01

    N-substituted-(indol-3-yl)carboxamides 10-15 and alkanamides 16-18 were prepared starting from the corresponding acids and submitted to screening for evaluation of their anti-inflammatory activity. None of the considered carboxamides exhibited significant inhibitory effect in the carrageenin-induced rat paw oedema after oral administration of 0.1 mM x kg(-1); nevertheless introduction of an alkyl chain, leading to alkanamides 16-18, induced moderate to high activity: 46-95% inhibition. The efficacy of these compounds in the inhibition of topical inflammation was confirmed by measuring reduction of ear thickness in the acute tetradecanoyl phorbol acetate (TPA)-induced mouse ear swelling assay. Preliminary pharmacomodulation brought to the fore that toxic effects induced, at 0.4 mM x kg(-1), by N-(pyridin-4-yl)(indol-3-yl)propanamide (17) could be attenuated or suppressed by 5-fluorination or introduction of a methoxycarbonylborane moiety, leading to 18 and 21.

  7. Formulation and in vitro evaluation of clotrimazole gel containing almond oil and tween 80 as penetration enhancer for topical application.

    Science.gov (United States)

    Nawaz, Asif; Jan, Syed Umer; Khan, Nauman Rahim; Hussain, Abid; Khan, Gul Majid

    2013-05-01

    Achieving a desirable percutaneous absorption of drug molecule is a major concern in formulating dermal and transdermal products. The use of penetration enhancers could provide a successful mean for this purpose. The aim of this study was to develop Clotrimazole gel and to evaluate the effect of almond oil and tween 80 (in different concentrations), on the permeation of drug through rabbit skin in vitro. In order to investigate the effect of penetration enhancers used in this study on the permeation of Clotrimazole through sections of excised rabbit skin, Franz diffusion cell was employed. Sample solution was withdrawn at specific time interval up to 24 h. Significant difference in permeation among the eight formulations was seen in the study. The permeation profile of various formulations also showed that the added enhancers in individual batches affected the permeation of the drug. Drug permeation increased with increased concentration of Tween 80 and decreased concentration of almond oil. Furthermore, almond oil combined with tween 80 showed synergistic effect. The clotrimazole gels were successfully formulated and could be beneficial for topical use.

  8. Alkyl polyglucoside-stabilized emulsion as a prospective vehicle for Usnea barbata CO2-supercritical extract: Assessing stability, safety and efficiency of a topical formulation

    Directory of Open Access Journals (Sweden)

    Žugić Ana R.

    2015-01-01

    Full Text Available Antimicrobial activity of Usnea barbata especially against bacteria involved in pathogenesis of various skin conditions has been well documented in literature. Nevertheless, there are no papers dealing with formulation of its isolates into topical preparations for treatment of skin infections. In present study, alkyl polyglucoside (APG - based vehicle was developed as carrier of U. barbata CO2-supercritical extract (U-SE that demonstrated the best antimicrobial potential in preliminary screening. For comparison, chosen extract in the same concentration and using the same procedure was incorporated into a pharmacopoeial vehicle. Comparative evaluation of physicochemical stability, efficiency and safety proved APG-based vehicle to possess certain preferential features as carrier of U-SE compared to the reference one, composing a topical formulation with potential clinical relevance in treatment of skin infections. [Projekat Ministarstva nauke Republike Srbije, br. III45017 i br. TR34031

  9. Textile Architecture

    DEFF Research Database (Denmark)

    Heimdal, Elisabeth Jacobsen

    2010-01-01

    Textiles can be used as building skins, adding new aesthetic and functional qualities to architecture. Just like we as humans can put on a coat, buildings can also get dressed. Depending on our mood, or on the weather, we can change coat, and so can the building. But the idea of using textiles...... to create human habitation is not new. As Diether S. Hope phrases it, referring to tents: The history of development of humanity would be barely conceivable without free spanning textile membrane structures....

  10. Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products - Part 3: Mentha × piperita - Solanum dulcamara.

    Science.gov (United States)

    Calapai, Gioacchino; Minciullo, Paola L; Miroddi, Marco; Chinou, Ioanna; Gangemi, Sebastiano; Schmidt, Richard J

    2016-03-01

    This review focuses on contact dermatitis as an adverse effect of a selection of topically used herbal medicinal products for which the European Medicines Agency has completed an evaluation up to the end of November 2013 and for which a Community herbal monograph - now (since 2015)(†) called a European Union herbal monograph - has been produced. Part 3: Mentha × piperita L.-Solanum dulcamara L.

  11. Robotic Architectures

    Directory of Open Access Journals (Sweden)

    Mbali Mtshali

    2010-01-01

    Full Text Available In the development of mobile robotic systems, a robotic architecture plays a crucial role in interconnecting all the sub-systems and controlling the system. The design of robotic architectures for mobile autonomous robots is a challenging and complex task. With a number of existing architectures and tools to choose from, a review of the existing robotic architecture is essential. This paper surveys the different paradigms in robotic architectures. A classification of the existing robotic architectures and comparison of different proposals attributes and properties have been carried out. The paper also provides a view on the current state of designing robot architectures. It also proposes a conceptual model of a generalised robotic architecture for mobile autonomous robots.Defence Science Journal, 2010, 60(1, pp.15-22, DOI:http://dx.doi.org/10.14429/dsj.60.96

  12. Topical report review status

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-08-01

    This report provides industry with procedures for submitting topical reports, guidance on how the U.S. Nuclear Regulatory Commission (NRC) processes and responds to topical report submittals, and an accounting, with review schedules, of all topical reports currently accepted for review schedules, of all topical reports currently accepted for review by the NRC. This report will be published annually. Each sponsoring organization with one or more topical reports accepted for review copies.

  13. Using the C4ISR Architecture Framework as a Tool to Facilitate VV&A for Simulation Systems within the Military Application Domain

    CERN Document Server

    Tolk, Andreas

    2010-01-01

    To harmonize the individual architectures of the different commands, services, and agencies dealing with the development and procurement of Command, Control, Communications, Computing, Surveillance, Reconnaissance, and Intelligence (C4ISR) systems, the C4ISR Architecture Framework was developed based on existing and matured modeling techniques and methods. Within a short period, NATO adapted this method family as the NATO Consultation, Command, and Control (C3) System Architecture Framework to harmonize the efforts of the different nations. Based on these products, for every system to be fielded to be used in the US Armed Forces, a C4I Support Plan (C4ISP) has to be developed enabling the integration of the special system into the integrated C4I Architecture. The tool set proposed by these architecture frameworks connects operational views of the military user, system views of the developers, and the technical views for standards and integration methods needed to make the network centric system of systems wor...

  14. Use of abnormal and health psychology as topics in a classroom format to reduce alcohol and other drug abuse among college students at risk.

    Science.gov (United States)

    Miley, W M

    2001-12-01

    This study was done to assess whether classes containing topics derived from two college courses, Abnormal Psychology and Health Psychology, could be used in a class room format to reduce alcohol and other drug abuse among at-risk college students. Topics covered included stress and stress management, alcohol and other drug use and abuse, chronic illnesses and psychological disorders that develop from an unhealthy lifestyle, and factors that play a role in good health and well-being. Students were enrolled in a semester-long course for college credit as an alternative to punitive sanctions for on-campus alcohol violations and other drug violations. The Midwest Institute on Drug Use Survey and the CORE Alcohol and Drug Survey were administered on the first and last days of class. Analysis indicated a significant self-reported reduction in drug use and associated negative symptoms and behavioral effects. Women were more likely to report reductions in drug use than men.

  15. Architecture & Environment

    Science.gov (United States)

    Erickson, Mary; Delahunt, Michael

    2010-01-01

    Most art teachers would agree that architecture is an important form of visual art, but they do not always include it in their curriculums. In this article, the authors share core ideas from "Architecture and Environment," a teaching resource that they developed out of a long-term interest in teaching architecture and their fascination with the…

  16. Evaluation of RU58841 as an anti-androgen in prostate PC3 cells and a topical anti-alopecia agent in the bald scalp of stumptailed macaques.

    Science.gov (United States)

    Pan, H J; Wilding, G; Uno, H; Inui, S; Goldsmith, L; Messing, E; Chang, C

    1998-08-01

    The effect of androgen receptor transcriptional activation by RU58841, a nonsteroidal anti-androgen, was studied in the human prostate cancer PC3 cell line by cotransfection with wild-type androgen receptor (wt AR) and an androgen-responsive reporter (MMTV-ARE-CAT) construct. Anti-and rogens, hydroxyflutamide, and Casodex, and the antiestrogen, genistein, were studied in parallel for comparison with RU58841. The wt AR was activated only by the androgen dihydrotestosterone (DHT). Neither the anti-androgens nor antiestrogen can enhance AR transcriptional activity at 10(-11)-10(-7)M in PC3 cells. Hydroxyflutamide, RU58841, and Casodex, but not genistein, displayed competitively suppressive effects on DHT activation of wt AR. The potency of RU58841 was comparable to that of hydroxyflutamide. From this result, topical application of RU58841, which is considered to be a potential therapy for skin diseases, may induce systemic side effects. However, RU58841, on topical application, revealed a potent increase in density, thickening, and length of hair in the macaque model of androgenetic alopecia, whereas no systemic effects were detected. Together our results suggest that RU58841 may have potent antagonism to the wt AR and could be considered as a topically applied active anti-androgen for the treatment of androgen-dependent skin disorders, such as acne, androgenetic alopecia, and hirsutism.

  17. Unrealized Architectural Projects in Lithuania: Historical Development

    Directory of Open Access Journals (Sweden)

    Indrė Gudelytė

    2012-05-01

    Full Text Available The “unrealized architectural projects” are the building projects, carried out under the specific design task and intended to be built in a particular place (site, though, for certain reasons and circumstances, have never been constructed. However, up to the present day, the topic of the “unbuilt” has been analyzed just episodically in literature and sources. The article touches upon the historical development of unrealized architectural works, as well as their artistic value and role within various historical periods of Lithuanian architecture. One of the chapters briefly reviews the relevance and development of unrealized projects during the period since Czarist Russian occupation (1795 to the restoration of Lithuanian independence (1990. Furthermore, the deeper analysis of the Soviet period (1940–1990 “dead” architecture is presented. While exploring “the unrealized”, attention has been also paid to what was actu ally built, therefore the prevailing architectural styles, tendencies and examples of the corresponding decade (in Lithuania and worldwide have been studied.Article in Lithuanian

  18. 2 PROBLEM OF PRESERVATION OF ARCHITECTURAL MONUMENTS OF OLD MOSCOW AS VIEWED BY ITS RESIDENTS

    Directory of Open Access Journals (Sweden)

    Savitskaya Anastasiya Valer'evna

    2015-01-01

    Full Text Available The authors consider one of the most relevant issues of the present-day urban planning, the issue of preservation of the historic environment, the architectural and urban planning space of the megalopolis in the context of the accelerated pace of urbanization, expansion of the capital in the course of its implementation. The authors argue that the problem considered in the paper is not easy to tackle. The point is that the need to preserve historic built-up areas is hardly reconcilable with the need to upgrade the urban infrastructure. A social conflict is inevitable in this context. The authors track development of this social conflict from the sixties of the 20ieth century and through the present time and provide their resolutions to this contradiction.

  19. Garden as 1:1: Between Paper Thinking and Earth Moving in Landscape Architectural Learning

    Directory of Open Access Journals (Sweden)

    Fiona Harrisson

    2016-09-01

    Full Text Available Decisions about design are invariably decisions about materials (Temple, 2011,p 50.Design education seeks to mimic the design process in landscape architectural practice. Yet the educational process is fundamentally different because design ideas are rarely tested through building. Student learning, therefore, remains in the realm of abstraction: the representation of a design idea without translation into the actual material these ideas are intended to shape. Thinking through ideas at full scale off ers an alternative way to explore design learning so students understand the spatial, social and material consequences of their ideas. Working at the 1:1 scale gives them an insight into the implications of their design decisions and experience in working directly with the materials of their concern. It also off ers an opportunity to work one to one with each other and clients.

  20. An Idiotypic Immune Network as a Short Term Learning Architecture for Mobile Robots

    CERN Document Server

    Whitbrook, Amanda; Garibaldi, Jonathan M

    2009-01-01

    A combined Short-Term Learning (STL) and Long-Term Learning (LTL) approach to solving mobile robot navigation problems is presented and tested in both real and simulated environments. The LTL consists of rapid simulations that use a Genetic Algorithm to derive diverse sets of behaviours. These sets are then transferred to an idiotypic Artificial Immune System (AIS), which forms the STL phase, and the system is said to be seeded. The combined LTL-STL approach is compared with using STL only, and with using a handdesigned controller. In addition, the STL phase is tested when the idiotypic mechanism is turned off. The results provide substantial evidence that the best option is the seeded idiotypic system, i.e. the architecture that merges LTL with an idiotypic AIS for the STL. They also show that structurally different environments can be used for the two phases without compromising transferability

  1. Discrete geometric structures for architecture

    KAUST Repository

    Pottmann, Helmut

    2010-06-13

    topic is closely related to the classical geometry of webs. There are numerous open problems in the geometry of webs, in particular when one asks for webs formed by special types of curves, as preferred in applications such as architecture.

  2. Canine tarsal architecture as revealed by high-resolution computed tomography.

    Science.gov (United States)

    Galateanu, G; Apelt, D; Aizenberg, I; Saragusty, J; Hildebrandt, T B

    2013-06-01

    Central tarsal bone (CTB) fractures are well documented and are a subject of increasing importance in human, equine and canine athletes although the mechanism of these fractures in dogs is not fully understood and an extrapolation from human medicine may not be accurate. This study reports the use of high-resolution computed tomography (CT) of 91 tarsal joints from 47 dogs to generate a more detailed in situ anatomical description of the CTB architecture in order to obtain a better understanding of the pathogenesis of CTB fractures in this species. The dogs studied represented a wide range of ages, breeds and levels of habitual physical activity and the angles of the tarsal joints studied ranged between maximal flexion (16.4°) and maximal extension (159.1°). Regardless of tarsal angle, the CTB articulated with the calcaneus exclusively at the level of its plantar process (PPCTB) in all dogs. The PPCTB presented two distinct parts in all dogs, a head and a neck. The calcaneus tended to rely on the PPCTB neck during flexion and on the PPCTB head during extension. This study describes new tarsal elements for the first time, including the calcaneal articular process, the fourth tarsal bone plantar articular process and the talar plantar prominence of the CTB. Based on calcaneo-PPCTB architecture, it is postulated that the PPCTB is a keystone structure and that at least some of CTB fractures in dogs could either commence at or are induced at this level due to the impingement forces exercised by the calcaneus.

  3. Challenges and Weaknesses of Agile Method in Enterprise Architecture

    Directory of Open Access Journals (Sweden)

    Zahra Askarinejad Amiri

    2013-01-01

    Full Text Available As Information Technologies (IT grow in complexity and scope, the need for a coherent approach toenterprise wide modelling becomes paramount. Changing is one of the most important challenges thatorganisation encounter. The topic of enterprise architecture has been gaining significant attention fromboth academia and industry due to the inefficiencies of current IT architecture to cope with rapid changesin business environment. Apart from that, Agile is new concept that present in EA recently. It tries to beadaptive with frequently changes which occurred in organisation. There are some agile methodology andmethod with maintain agile manifesto. Briefly they use agile practices in their development such as XP,Scrum and service oriented architecture. Each of them follows some challenges that lead to less usabilityof them in EA. This research intends to identify these challenges and proposed method to improve theusability of agility in enterprise architecture.

  4. Asignifying Semiotics as Proto-Theory of Singularity: Drawing is Not Writing and Architecture does Not Speak

    Directory of Open Access Journals (Sweden)

    Andrej Radman

    2014-05-01

    Full Text Available We have recently witnessed a confession of a fellow architect with which we fully identify. We, too, belong to the generation educated under the semiotic regime, which – as we will argue in our introduction – has run its course. We also believe that the idea of ‘architecture as language’ might have been useful as an analytical tool but never as a design mechanism. After all, creativity comes first and routinisation follows. As the title of Footprint 14 suggests, this is a general plea to have done with the hegemony of the linguistic signifier. Signifying semiotics is but a fraction of a much broader asignifying semiotics. We propose to approach the issue qua Spinozist practice of ethology, defined as the study of capacities, or – as we would like to think of it – a proto-theory of singularity. This is as much an ethical or political problem as it is an aesthetic one. It concerns what the cultural critic Steven Shaviro recently qualified as a primordial form of sentience that is non-intentional, non-correlational, and anoetic. The Affective Turn will be measured against the unavoidable Digital Turn. We will conclude by reversing the famous Wittgensteinian dictum whereby what we cannot speak about we must not pass over in silence. A brief summary of contributions, which are by no means limited to architecture, is concluded with a politically charged epilogue. The very last paragraph of the epilogue reveals the pink-on-pink reference.

  5. Persian architecture and mathematics

    CERN Document Server

    2012-01-01

    This volulme features eight original papers dedicated to the theme “Persian Architecture and Mathematics,” guest edited by Reza Sarhangi. All papers were approved through a rigorous process of blind peer review and edited by an interdisciplinary scientific editorial committee. Topics range from symmetry in ancient Persian architecture to the elaborate geometric patterns and complex three-dimensional structures of standing monuments of historical periods, from the expression of mathematical ideas to architectonic structures, and from decorative ornament to the representation of modern group theory and quasi-crystalline patterns. The articles discuss unique monuments Persia, including domed structures and two-dimensional patterns, which have received significant scholarly attention in recent years. This book is a unique contribution to studies of Persian architecture in relation to mathematics.

  6. Catalyst Architecture

    DEFF Research Database (Denmark)

    Kiib, Hans; Marling, Gitte; Hansen, Peter Mandal

    2014-01-01

    of programs, have a role in mediating positive social and/or cultural development. In this sense, we talk about architecture as a catalyst for: sustainable adaptation of the city’s infrastructure appropriate renovation of dilapidated urban districts strengthening of social cohesiveness in the city development...... meaningful for everyone. The exhibited works are designed by SANAA, Diller Scofidio + Renfro, James Corner Field Operation, JBMC Arquitetura e Urbanismo, Atelier Bow-Wow, Ateliers Jean Nouvel, COBE, Transform, BIG, Topotek1, Superflex, and by visual artist Jane Maria Petersen....

  7. Towards a Media Architecture

    DEFF Research Database (Denmark)

    Ebsen, Tobias

    2010-01-01

    This text explores the concept of media architecture as a phenomenon of visual culture that describes the use of screen-technology in new spatial configurations in practices of architecture and art. I shall argue that this phenomenon is not necessarily a revolutionary new approach, but rather...... a result of conceptual changes in both modes visual representation and in expressions of architecture. These are changes the may be described as an evolution of ideas and consequent experiments that can be traced back to changes in the history of art and the various styles and ideologies of architecture....

  8. Elements of Architecture

    DEFF Research Database (Denmark)

    Elements of Architecture explores new ways of engaging architecture in archaeology. It conceives of architecture both as the physical evidence of past societies and as existing beyond the physical environment, considering how people in the past have not just dwelled in buildings but have existed...... and affective impacts, of these material remains. The contributions in this volume investigate the way time, performance and movement, both physically and emotionally, are central aspects of understanding architectural assemblages. It is a book about the constellations of people, places and things that emerge...

  9. A Phobos-Deimos Mission as an Element of the NASA Mars Design Reference Architecture 5.0

    Science.gov (United States)

    Hoffman, Stephen J.

    2011-01-01

    NASA has conducted a series of mission studies over the past 25 years examining the eventual exploration of the surface of Mars by humans. The latest version of this evolutionary series of design reference missions/architectures - Design Reference Architecture 5 or DRA-5 - was completed in 2007. This paper examines the implications of including a human mission to explore the moons of Mars and teleoperate robots in various locations, but not to land the human crews on Mars, as an element of this reference architecture. Such a mission has been proposed several times during this same 25 year evolution leading up to the completion of DRA-5 primarily as a mission of testing the in-space vehicles and operations while surface vehicles and landers are under development. But such a precursor or test mission has never been explicitly included as an element of this Architecture. This paper will first summarize the key features of the DRA-5 to provide context for the remainder of the assessment. This will include a description of the in-space vehicles that would be the subject of a shakedown test during the Mars orbital mission. A decision tree will be used to illustrate the factors that will be analyzed, and the sequence in which they will be addressed, for this assessment. The factors that will be analyzed include the type of interplanetary transfer orbit (opposition class versus conjunction class), the type of parking orbit (circular versus elliptical), and the type of propulsion technology (high thrust chemical versus nuclear thermal rocket). The manner in which each of these factors impacts an individual mission will be described. In addition to the direct impact of these factors, additional considerations impacting crew health and overall programmatic outcomes will be discussed. Numerical results for each of the factors in the decision tree will be grouped with derived qualitative impacts from crew health and programmatic consideration. These quantitative and qualitative

  10. The Use of MIVES as a Sustainability Assessment MCDM Method for Architecture and Civil Engineering Applications

    Directory of Open Access Journals (Sweden)

    Oriol Pons

    2016-05-01

    Full Text Available Environmental and sustainability assessment tools have an important role in moving towards a better world, bringing knowledge and raising awareness. In the architecture and civil engineering sector, these assessment tools help in moving forward to constructions that have less economic, environmental and social impacts. At present, there are numerous assessment tools and methods with different approaches and scopes that have been analyzed in numerous technical reviews. However, there is no agreement about which method should be used for each evaluation case. This research paper synthetically analyzes the main sustainability assessment methods for the construction sector, comparing their strengths and weaknesses in order to present the challenges of the Spanish Integrated Value Model for Sustainability Assessment (MIVES. MIVES is a Multi-Criteria Decision Making method based on the value function concept and the Seminars of experts. Then, this article analyzes MIVES advantages and weak points by going through its methodology and two representative applications. At the end, the area of application of MIVES is described in detail along with the general application cases of the main types of assessment tools and methods.

  11. A Flexible LDPC code decoder with a Network on Chip as underlying interconnect architecture

    CERN Document Server

    Condo, Carlo

    2011-01-01

    LDPC (Low Density Parity Check) codes are among the most powerful and widely adopted modern error correcting codes. The iterative decoding algorithms required for these codes involve high computational complexity and high processing throughput is achieved by allocating a sufficient number of processing elements (PEs). Supporting multiple heterogeneous LDPC codes on a parallel decoder poses serious problems in the design of the interconnect structure for such PEs. The aim of this work is to explore the feasibility of NoC (Network on Chip) based decoders, where full flexibility in terms of supported LDPC codes is obtained resorting to an NoC to connect PEs. NoC based LDPC decoders have been previously considered unfeasible because of the cost overhead associated to packet management and routing. On the contrary, the designed NoC adopts a low complexity routing, which introduces a very limited cost overhead with respect to architectures dedicated to specific classes of codes. Moreover the paper proposes an effic...

  12. REQUIREMENT PLANNING IN MATERIAL RESOURCES AS THE PART OF THE OPTIMUM ENTERPRISE ARCHITECTURE

    Directory of Open Access Journals (Sweden)

    Shavaleeva, D.N.

    2017-01-01

    Full Text Available In the conditions of market economy there is urgent an enhancement of the organization of enterprise management and, first of all, a production process, effective use of financial, material resources, material inventories, etc. Now it is necessary to arm financial managers with purposeful system of methods and algorithms of reasons for the most effective management decisions on separate aspects of financial activities, to implement modern mechanisms of financial management in practice of managing of the entities. Effective management of material resources raises profit and provides necessary investments. For maintenance of high profitability and liquidity the significant role is played by management of the current activities of the entities, in particular management of material inventories. Business process "Requirement planning in material resources" is a part of an enterprise architecture and determines a planning order on the basis of the approved consumption rates and an inventory of material resources taking into account involvement in turnover of materials from unused and above-standard inventories of a current period that allows to create a composite planned balance of deliveries, including in the directions of use of material resources.

  13. Diclofenac Topical (osteoarthritis pain)

    Science.gov (United States)

    Diclofenac topical gel (Voltaren) is used to relieve pain from osteoarthritis (arthritis caused by a breakdown of the ... the knees, ankles, feet, elbows, wrists, and hands. Diclofenac topical liquid (Pennsaid) is used to relieve osteoarthritis pain ...

  14. Topics in Operator Theory

    CERN Document Server

    Ball, Joseph A; Helton, JWilliam; Rodman, Leiba; Spitkovsky, Iiya

    2010-01-01

    This is the first volume of a collection of original and review articles on recent advances and new directions in a multifaceted and interconnected area of mathematics and its applications. It encompasses many topics in theoretical developments in operator theory and its diverse applications in applied mathematics, physics, engineering, and other disciplines. The purpose is to bring in one volume many important original results of cutting edge research as well as authoritative review of recent achievements, challenges, and future directions in the area of operator theory and its applications.

  15. Topics in field theory

    CERN Document Server

    Karpilovsky, G

    1989-01-01

    This monograph gives a systematic account of certain important topics pertaining to field theory, including the central ideas, basic results and fundamental methods.Avoiding excessive technical detail, the book is intended for the student who has completed the equivalent of a standard first-year graduate algebra course. Thus it is assumed that the reader is familiar with basic ring-theoretic and group-theoretic concepts. A chapter on algebraic preliminaries is included, as well as a fairly large bibliography of works which are either directly relevant to the text or offer supplementary material of interest.

  16. Software architecture as a freedom for 3D content providers and users along with independency on purposes and used devices

    Science.gov (United States)

    Sultana, Razia; Christ, Andreas; Meyrueis, Patrick

    2014-05-01

    The improvements in the hardware and software of communication devices have allowed running Virtual Reality (VR) and Augmented Reality (AR) applications on those. Nowadays, it is possible to overlay synthetic information on real images, or even to play 3D on-line games on smart phones or some other mobile devices. Hence the use of 3D data for business and specially for education purposes is ubiquitous. Due to always available at hand and always ready to use properties of mobile phones, those are considered as most potential communication devices. The total numbers of mobile phone users are increasing all over the world every day and that makes mobile phones the most suitable device to reach a huge number of end clients either for education or for business purposes. There are different standards, protocols and specifications to establish the communication among different communication devices but there is no initiative taken so far to make it sure that the send data through this communication process will be understood and used by the destination device. Since all the devices are not able to deal with all kind of 3D data formats and it is also not realistic to have different version of the same data to make it compatible with the destination device, it is necessary to have a prevalent solution. The proposed architecture in this paper describes a device and purpose independent 3D data visibility any time anywhere to the right person in suitable format. There is no solution without limitation. The architecture is implemented in a prototype to make an experimental validation of the architecture which also shows the difference between theory and practice.

  17. Reflection on Full Life Cycle Green Architectural Design of Passive Priority---Taking the Award Design of China Merchants Property 2013 Green Architectural Design Competition as an Example

    Institute of Scientific and Technical Information of China (English)

    ZhenHe Fan; Yan Qiao

    2014-01-01

    In the China merchants property 2013 green architectural design competition, feature of this award-winning program is the design method based on the principles of passive priority and comprehensive utilization of full life cycle. The passive priority can be achieved by building form derived from the simulation and analysis of wind environment, improvement of the building envelope insulation and the dehumidification of fresh air, the use of solar energy. The full life cycle utilization can be accomplished by the combination of exhibition and residents’ leisure activities, and the integration with local cultural tradition, thereby improving energy efficiency and the utilization of the building.

  18. Dual-Stack Single-Radio Communication Architecture for UAV Acting As a Mobile Node to Collect Data in WSNs

    Directory of Open Access Journals (Sweden)

    Ali Sayyed

    2015-09-01

    Full Text Available The use of mobile nodes to collect data in a Wireless Sensor Network (WSN has gained special attention over the last years. Some researchers explore the use of Unmanned Aerial Vehicles (UAVs as mobile node for such data-collection purposes. Analyzing these works, it is apparent that mobile nodes used in such scenarios are typically equipped with at least two different radio interfaces. The present work presents a Dual-Stack Single-Radio Communication Architecture (DSSRCA, which allows a UAV to communicate in a bidirectional manner with a WSN and a Sink node. The proposed architecture was specifically designed to support different network QoS requirements, such as best-effort and more reliable communications, attending both UAV-to-WSN and UAV-to-Sink communications needs. DSSRCA was implemented and tested on a real UAV, as detailed in this paper. This paper also includes a simulation analysis that addresses bandwidth consumption in an environmental monitoring application scenario. It includes an analysis of the data gathering rate that can be achieved considering different UAV flight speeds. Obtained results show the viability of using a single radio transmitter for collecting data from the WSN and forwarding such data to the Sink node.

  19. Dual-Stack Single-Radio Communication Architecture for UAV Acting As a Mobile Node to Collect Data in WSNs

    Science.gov (United States)

    Sayyed, Ali; Medeiros de Araújo, Gustavo; Bodanese, João Paulo; Buss Becker, Leandro

    2015-01-01

    The use of mobile nodes to collect data in a Wireless Sensor Network (WSN) has gained special attention over the last years. Some researchers explore the use of Unmanned Aerial Vehicles (UAVs) as mobile node for such data-collection purposes. Analyzing these works, it is apparent that mobile nodes used in such scenarios are typically equipped with at least two different radio interfaces. The present work presents a Dual-Stack Single-Radio Communication Architecture (DSSRCA), which allows a UAV to communicate in a bidirectional manner with a WSN and a Sink node. The proposed architecture was specifically designed to support different network QoS requirements, such as best-effort and more reliable communications, attending both UAV-to-WSN and UAV-to-Sink communications needs. DSSRCA was implemented and tested on a real UAV, as detailed in this paper. This paper also includes a simulation analysis that addresses bandwidth consumption in an environmental monitoring application scenario. It includes an analysis of the data gathering rate that can be achieved considering different UAV flight speeds. Obtained results show the viability of using a single radio transmitter for collecting data from the WSN and forwarding such data to the Sink node. PMID:26389911

  20. Dual-Stack Single-Radio Communication Architecture for UAV Acting As a Mobile Node to Collect Data in WSNs.

    Science.gov (United States)

    Sayyed, Ali; de Araújo, Gustavo Medeiros; Bodanese, João Paulo; Becker, Leandro Buss

    2015-09-16

    The use of mobile nodes to collect data in a Wireless Sensor Network (WSN) has gained special attention over the last years. Some researchers explore the use of Unmanned Aerial Vehicles (UAVs) as mobile node for such data-collection purposes. Analyzing these works, it is apparent that mobile nodes used in such scenarios are typically equipped with at least two different radio interfaces. The present work presents a Dual-Stack Single-Radio Communication Architecture (DSSRCA), which allows a UAV to communicate in a bidirectional manner with a WSN and a Sink node. The proposed architecture was specifically designed to support different network QoS requirements, such as best-effort and more reliable communications, attending both UAV-to-WSN and UAV-to-Sink communications needs. DSSRCA was implemented and tested on a real UAV, as detailed in this paper. This paper also includes a simulation analysis that addresses bandwidth consumption in an environmental monitoring application scenario. It includes an analysis of the data gathering rate that can be achieved considering different UAV flight speeds. Obtained results show the viability of using a single radio transmitter for collecting data from the WSN and forwarding such data to the Sink node.

  1. Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket.

    Science.gov (United States)

    Krull, Sandra; Thyberg, Johan; Björkroth, Birgitta; Rackwitz, Hans-Richard; Cordes, Volker C

    2004-09-01

    The vertebrate nuclear pore complex (NPC) is a macromolecular assembly of protein subcomplexes forming a structure of eightfold radial symmetry. The NPC core consists of globular subunits sandwiched between two coaxial ring-like structures of which the ring facing the nuclear interior is capped by a fibrous structure called the nuclear basket. By postembedding immunoelectron microscopy, we have mapped the positions of several human NPC proteins relative to the NPC core and its associated basket, including Nup93, Nup96, Nup98, Nup107, Nup153, Nup205, and the coiled coil-dominated 267-kDa protein Tpr. To further assess their contributions to NPC and basket architecture, the genes encoding Nup93, Nup96, Nup107, and Nup205 were posttranscriptionally silenced by RNA interference (RNAi) in HeLa cells, complementing recent RNAi experiments on Nup153 and Tpr. We show that Nup96 and Nup107 are core elements of the NPC proper that are essential for NPC assembly and docking of Nup153 and Tpr to the NPC. Nup93 and Nup205 are other NPC core elements that are important for long-term maintenance of NPCs but initially dispensable for the anchoring of Nup153 and Tpr. Immunogold-labeling for Nup98 also results in preferential labeling of NPC core regions, whereas Nup153 is shown to bind via its amino-terminal domain to the nuclear coaxial ring linking the NPC core structures and Tpr. The position of Tpr in turn is shown to coincide with that of the nuclear basket, with different Tpr protein domains corresponding to distinct basket segments. We propose a model in which Tpr constitutes the central architectural element that forms the scaffold of the nuclear basket.

  2. Linguistic Extensions of Topic Models

    Science.gov (United States)

    2010-09-01

    class of corpora and would help monolingual users to explore and understand multilingual corpora. In this chapter, we develop multilingual LDAWN, an... Multilingual Priors As in the case of a monolingual walk over the concept hierarchy, we want to provide guidance to the multilingual model as to which parts...topic models for new datasets, such as unaligned multilingual corpora, and combine topic models with other sources of information about documents’ context

  3. Information architecture. Volume 3: Guidance

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-04-01

    The purpose of this document, as presented in Volume 1, The Foundations, is to assist the Department of Energy (DOE) in developing and promulgating information architecture guidance. This guidance is aimed at increasing the development of information architecture as a Departmentwide management best practice. This document describes departmental information architecture principles and minimum design characteristics for systems and infrastructures within the DOE Information Architecture Conceptual Model, and establishes a Departmentwide standards-based architecture program. The publication of this document fulfills the commitment to address guiding principles, promote standard architectural practices, and provide technical guidance. This document guides the transition from the baseline or defacto Departmental architecture through approved information management program plans and budgets to the future vision architecture. This document also represents another major step toward establishing a well-organized, logical foundation for the DOE information architecture.

  4. Architecture and Stages

    DEFF Research Database (Denmark)

    Kiib, Hans

    2009-01-01

    as "experiencescape" - a space between tourism, culture, learning and economy. Strategies related to these challenges involve new architectural concepts and art as ‘engines' for a change. New expressive architecture and old industrial buildings are often combined into hybrid narratives, linking the past...

  5. Topical rapamycin as a treatment for fibrofolliculomas in Birt-Hogg-Dube syndrome: a double-blind placebo-controlled randomized split-face trial.

    Directory of Open Access Journals (Sweden)

    Lieke M C Gijezen

    Full Text Available BACKGROUND: Birt-Hogg-Dubé syndrome (BHD is a rare autosomal dominant disorder characterised by the occurrence of benign, mostly facial, skin tumours called fibrofolliculomas, multiple lung cysts, spontaneous pneumothorax and an increased renal cancer risk. Current treatments for fibrofolliculomas have high rates of recurrence and carry a risk of complications. It would be desirable to have a treatment that could prevent fibrofolliculomas from growing. Animal models of BHD have previously shown deregulation of mammalian target of rapamycin (mTOR. Topical use of the mTOR inhibitor rapamycin is an effective treatment for the skin tumours (angiofibromas in tuberous sclerosis complex, which is also characterised by mTOR deregulation. In this study we aimed to determine if topical rapamycin is also an effective treatment for fibrofolliculomas in BHD. METHODS: We performed a double blinded, randomised, facial left-right controlled trial of topical rapamycin 0.1% versus placebo in 19 BHD patients. Trial duration was 6 months. The primary outcome was cosmetic improvement as measured by doctors and patients. Changes in fibrofolliculoma number and size were also measured, as was occurrence of side effects. RESULTS: No change in cosmetic status of fibrofolliculomas was reported in the majority of cases for the rapamycin treated (79% by doctors, 53% by patients as well as the placebo treated facial sides (both 74%. No significant differences between rapamycin and placebo treated facial halves were observed (p = 1.000 for doctors opinion, p = 0.344 for patients opinion. No significant difference in fibrofolliculoma number or change in size of the fibrofolliculomas was seen after 6 months. Side effects occurred more often after rapamycin treatment (68% of patients than after placebo (58% of patients; p = 0.625. A burning sensation, erythema, itching and dryness were most frequently reported. CONCLUSIONS: This study provides no evidence that

  6. Critical Analysis of Criteria-Based Assessment and Grading in Architecture Education (Universiti Kebangsaan Malaysia as Case Study

    Directory of Open Access Journals (Sweden)

    Badiossadat Hassanpour

    2012-07-01

    Full Text Available Education is a contiguous and consecutive process. Thereby learning skills and knowledge in any context, requires strong and powerful academic basis. To reach this target, evaluation as a means to recognize student’s learning level and making decisions for further educating steps seems essential. All the Educational systems have sort of official examination, assessment or grading policy to measure student’s learning stage. In the typical policy, students are told clearly about the proposed assessment program and the relative weightings of the various components and they are given timely and helpful feedback after each assessment stage. Internationally, in these decades, universities and educators have become increasingly committed to making assessment and grading more effective in promoting student learning. Appraisal methods and grading systems in studio based educating systems, such as architecture, more than other majors and fields needs attention and scrutiny. Because transmitting the success amount of solving ill-defined problems in design studios to grading symbols are more difficult than multiple choice tests and even open ended questions. The primary interest of this study is in grading methods that claim to be criteria-based. This study tries to hybrid the criteria based models to introduce a new appraisal method in evaluating architectural projects in universities, based on a review of the most common grading policies.

  7. The school textbook as a research topic in the history of education: notes to the geography text

    OpenAIRE

    Jorge Alejandro Aguirre Rueda

    2015-01-01

    The school textbook as memory space, ideological and pedagogical tool vector has emerged as a new piece of research for historians. Undervalued for a long time, today it brings critical information to understand the initial processes of socialization that took place within schools. One of them, indeed, has been the textbook of geography, which is shown as vehicle tool for many national messages about the territory and the population. It was evident that in Spain, Mexico, Guatemala, Colombia, ...

  8. Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, S.; Pathak, M.A.; Fitzpatrick, T.B. [Massachusetts General Hospital, Harvard Medical School, Dept. of Dermatology, Boston, MA (United States); Cuevas, J. [Hospital Universitario de Guadalajara, Dept. of Pathology, Guadalajara (Spain); Villarrubia, V.G. [I.F. Cantabria SA, Medical Dept., Immunology Sect., Madrid (Spain)

    1997-12-31

    Sunburn, immune suppression, photo-aging, and skin cancers result from uncontrolled overexposure of human skin to solar ultraviolet radiation (UVR). Preventive measures, including photo-protection, are helpful and can be achieved by topical sun-screening agents. Polypodium leucotomos (PL) has been used for the treatment of inflammatory diseases and has shown some in vitro and in vivo immunomodulating properties. Its beneficial photo-protective effects in the treatment of vitiligo and its antioxidant properties encouraged us to evaluate in vivo the potentially useful photo-protective property of natural extract of PL after topical application or oral ingestion. Twenty-one healthy volunteers [either untreated or treated with oral psoralens (8-MOP or 5-MOP)] were enrolled in this study and exposed to solar radiation for evaluation of the following clinical parameters: immediate pigment darkening (IPD), minimal erythema dose (MED), minimal melanogenic dose (MMD), and minimal phototoxic dose (MPD) before and after topical or oral administration of PL. Immunohistochemical assessment of CD1a-expressing epidermal cells were also performed. PL was found to be photo-protective after topical application as well as oral administration. PL increased UV dose required for IPD (P<0.01), MED (P<0.001) and MPD (P<0.001). After oral administration of PL, MED increased 2.,8{+-}0.59 times and MPD increased 2.75{+-}0.5 and 6.8{+-}1.3 times depending upon the type of psoralen used. Immunohistochemical study revealed photo-protection of Langherhans cells by oral as well as topical PL. The observed photo-protective activities of oral or topical PL reveal a new avenue in examining the potentially useful field of systemic photo-protection and suggests that PL can be used as adjunct treatment and can make photochemotherapy and phototherapy possibly safe and effective when the control of cutaneous phototoxicity to PUVA or UVB is a limiting factor in such photo-therapies. (au). 50 refs.

  9. Green Architecture

    Science.gov (United States)

    Lee, Seung-Ho

    Today, the environment has become a main subject in lots of science disciplines and the industrial development due to the global warming. This paper presents the analysis of the tendency of Green Architecture in France on the threes axes: Regulations and Approach for the Sustainable Architecture (Certificate and Standard), Renewable Materials (Green Materials) and Strategies (Equipments) of Sustainable Technology. The definition of 'Green Architecture' will be cited in the introduction and the question of the interdisciplinary for the technological development in 'Green Architecture' will be raised up in the conclusion.

  10. Asignifying Semiotics as Proto-Theory of Singularity: Drawing is Not Writing and Architecture does Not Speak

    Directory of Open Access Journals (Sweden)

    Deborah Hauptmann

    2014-10-01

    Full Text Available We have recently witnessed a confession of a fellow architect with which we fully identify. We, too, belong to the generation educated under the semiotic regime, which – as we will argue in our introduction – has run its course. We also believe that the idea of ‘architecture as language’ might have been useful as an analytical tool but never as a design mechanism. After all, creativity comes first and routinisation follows. As the title of Footprint 14 suggests, this is a general plea to have done with the hegemony of the linguistic signifier. Signifying semiotics is but a fraction of a much broader asignifying semiotics. We propose to approach the issue qua Spinozist practice of ethology, defined as the study of capacities, or – as we would like to think of it – a proto-theory of singularity. This is as much an ethical or political problem as it is an aesthetic one. It concerns what the cultural critic Steven Shaviro recently qualified as a primordial form of sentience that is non-intentional, non-correlational, and anoetic. The Affective Turn will be measured against the unavoidable Digital Turn. We will conclude by reversing the famous Wittgensteinian dictum whereby what we cannot speak about we must not pass over in silence. A brief summary of contributions, which are by no means limited to architecture, is concluded with a politically charged epilogue. The very last paragraph of the epilogue reveals the pink-on-pink reference

  11. Topical erythropoietin as a novel preventive and therapeutic agent in bisphosphonate-related osteonecrosis of the jaw

    Directory of Open Access Journals (Sweden)

    Pantea Nazeman

    2016-01-01

    Full Text Available Introduction: One of the most common side effects of bisphosphonate intake is osteonecrosis of the jaw (ONJ which may develop following dentoalveolar interventions. Despite the vast available protocols, there is no clear guideline in the management of this condition. In osteonecrosis, the number and proliferation of bone-forming cells as well as vascularity are disturbed. Erythropoietin (EPO is a hematopoietic hormone with angiogenic, osteogenic, and antiapoptotic properties. The Hypothesis: It is suggested to utilize poly lactic-co-glycolic acid hydrogel containing 1500-3000 IU/kg EPO following dentoalveolar surgery in samples receiving bisphosphonates as a preventive or therapeutic agent. Evaluation of the Hypothesis: Considering the pathophysiology of ONJ and therapeutic properties of EPO, it is assumed that EPO may be effective in treatment of ONJ. Furthermore, as a preventive measure, utilizing EPO following dentoalveolar surgery may be beneficial in the patients at risk of ONJ.

  12. The school textbook as a research topic in the history of education: notes to the geography text

    Directory of Open Access Journals (Sweden)

    Jorge Alejandro Aguirre Rueda

    2015-01-01

    Full Text Available The school textbook as memory space, ideological and pedagogical tool vector has emerged as a new piece of research for historians. Undervalued for a long time, today it brings critical information to understand the initial processes of socialization that took place within schools. One of them, indeed, has been the textbook of geography, which is shown as vehicle tool for many national messages about the territory and the population. It was evident that in Spain, Mexico, Guatemala, Colombia, Ecuador, Chile and Argentina such themes and uses were recurrent and provided similar services. However, it was found that the vast majority of historical studies are still overestimating the role of the textbook, as already denounced Alain Choppin.

  13. Synergistic Combination of Chitosan Acetate with Nanoparticle Silver as a Topical Antimicrobial: Efficacy against Bacterial Burn Infections ▿

    OpenAIRE

    Huang, Liyi; Dai, Tianhong; Xuan, Yi; Tegos, George P.; Michael R. Hamblin

    2011-01-01

    Chitosan and nanoparticle silver are both materials with demonstrated antimicrobial properties and have been proposed singly or in combination as constituents of antimicrobial burn dressings. Here, we show that they combine synergistically to inhibit the in vitro growth of Gram-positive methicillin-resistant Staphylococcus aureus (MRSA) and Gram-negative bacteria (Pseudomonas aeruginosa, Proteus mirabilis, and Acinetobacter baumannii), as judged by bioluminescence monitoring and isobolographi...

  14. Mental Mechanisms for Topics Identification

    Directory of Open Access Journals (Sweden)

    Louis Massey

    2014-01-01

    Full Text Available Topics identification (TI is the process that consists in determining the main themes present in natural language documents. The current TI modeling paradigm aims at acquiring semantic information from statistic properties of large text datasets. We investigate the mental mechanisms responsible for the identification of topics in a single document given existing knowledge. Our main hypothesis is that topics are the result of accumulated neural activation of loosely organized information stored in long-term memory (LTM. We experimentally tested our hypothesis with a computational model that simulates LTM activation. The model assumes activation decay as an unavoidable phenomenon originating from the bioelectric nature of neural systems. Since decay should negatively affect the quality of topics, the model predicts the presence of short-term memory (STM to keep the focus of attention on a few words, with the expected outcome of restoring quality to a baseline level. Our experiments measured topics quality of over 300 documents with various decay rates and STM capacity. Our results showed that accumulated activation of loosely organized information was an effective mental computational commodity to identify topics. It was furthermore confirmed that rapid decay is detrimental to topics quality but that limited capacity STM restores quality to a baseline level, even exceeding it slightly.

  15. Clinical application of oral form of ANGIPARSTM and in combination with topical form as a new treatment for diabetic foot ulcers: A randomized clinical trial

    Directory of Open Access Journals (Sweden)

    Bahrami A

    2008-04-01

    Full Text Available ANGIPARSTM is a new herbal extract which has been produced in oral, topical, and intravenous forms. The present article contains preliminary results of the study which was planned to evaluate the efficacy and safety of orally applied ANGIPARSTM and to compare it with the combination of oral and topical forms and also with conventional therapy in patients with diabetic ulcers of the lower extremities."nTwenty one patients with diabetic foot ulcers were divided into 3 groups. The first group received 100 mg of oral ANGIPARSTM twice a day for 6 weeks in addition to conventional therapies. In the second group, ANGIPARSTM gel 3% was added to the oral form of the same product besides the conventional therapies for the same period of time. Finally, in the third group which was considered as control, only conventional therapies were performed. The patients were followed for 6 weeks. Parameters such as granulation tissue formation, skin epithelization, and wound surface areas changes were analyzed to determine the effectiveness of the compound in wounds healing. Furthermore, drug safety was assessed by monitoring adverse events and by clinical and laboratory evaluations."nThe study data showed significant differences between the intervention and control groups with respect to efficacy and tolerability. In each intervention group, primary wound healings occurred following 2 weeks. Complete wound healing which was greater than 70% improvement in wounds surface areas was achieved in 83% and 100% of group 1 and group 2 participants, respectively after 6 weeks. On the other hand, at the same period of time, only 22.2% of patients in control group revealed complete healing. Therefore, ANGIPARSTM had significant positive effect in increasing the incidence of complete wound closure compared with control group (p = 0.042. However, our evaluations indicated that adding topical treatment with 3% gel once a day to the oral therapy with the same product did not make

  16. The Genetic Architecture of Flowering Time and Photoperiod Sensitivity in Maize as Revealed by QTL Review and Meta Analysis

    Institute of Scientific and Technical Information of China (English)

    Jie Xu; Tingzhao Rong; Yaxi Liu; Jian Liu; Moju Cao; Jing Wang; Hai Lan; Yunbi Xu; Yanli Lu; Guangtang Pan

    2012-01-01

    The control of flowering is not only important for reproduction,but also plays a key role in the processes of domestication and adaptation.To reveal the genetic architecture for flowering time and photoperiod sensitivity,a comprehensive evaluation of the relevant literature was performed and followed by meta analysis.A total of 25 synthetic consensus quantitative trait loci (QTL) and four hot-spot genomic regions were identified for photoperiod sensitivity including 11 genes related to photoperiod response or flower morphogenesis and development.Besides,a comparative analysis of the QTL for flowering time and photoperiod sensitivity highlighted the regions containing shared and unique QTL for the two traits.Candidate genes associated with maize flowering were identified through integrated analysis of the homologous genes for flowering time in plants and the consensus QTL regions for photoperiod sensitivity in maize (Zea mays L.).Our results suggest that the combination of literature review,meta-analysis and homologous blast is an efficient approach to identify new candidate genes and create a global view of the genetic architecture for maize photoperiodic flowering.Sequences of candidate genes can be used to develop molecular markers for various models of marker-assisted selection,such as marker-assisted recurrent selection and genomic selection that can contribute significantly to crop environmental adaptation.

  17. CLOUD COMPUTING ARCHITECTURE FOR HIGHER EDUCATION IN THE THIRD WORLD COUNTRIES (REPUBLIC OF THE SUDAN AS MODEL

    Directory of Open Access Journals (Sweden)

    Mohmed Sirelkhtem Adrees

    2015-06-01

    Full Text Available The exponential growth in the volume of data and information lead to problems in management, controlling effective and high costs of storage operation, where organizations are having problems: data retrieval and preparation and backups, and other acts of data. Therefore seeking companies and business organizations at the present time to achieve the highest return on their investments in technology through the planning and implementation of virtualization technologies and cloud computing, in order to protect data and manage more effectively and efficiently. We find that the government funding for higher education is decreasing continuously in third world countries, and the education management stand for a set of challenges. Cloud computing can help to provide solutions for these challenges, they bring multiple solutions cannot be applied to regular IT models. This paper aims to discuss and analyzing: concepts of cloud computing, cloud computing models, cloud computing services, cloud computing Architecture and the main objective of this paper is to how to use and applied cloud computing Architecture in higher education, in third world countries, the republic of Sudan as a model.

  18. [Urban habitants' attitudes toward nature-approximating landscape architecture: taking Hongshan District of Wuhan City, China as a case].

    Science.gov (United States)

    Yang, Yu-ping; Zhou, Zhi-xiang; Cai, Shao-ping; Gao, Kai; Jia, Ruo

    2011-07-01

    Nature-approximating landscape architecture (NALA) is a concept of sustainable development as applied to landscape architecture, while the urban habitants' awareness and acceptance of NALA idea is the key for the successful application of NALA. Through semi-structured interview, this paper explored the attitudes of the habitants in Hongshan District of Wuhan City toward the NALA design and management, and the influence of the social-economic characteristics of the responders on their attitudes toward the NALA. A fairly low percentage of the responders approved of the NALA design (10.3% - 46.9%) and management (7.4% - 34.9%). The attitudes towards NALA design were mainly affected by the responders' age, and the attitudes toward NALA management were significantly correlated with the responders' age, educational level, and profession. The efficient cause why a large number of responders did not support the NALA was that these responders attached importance to the aesthetic effect of green space, and preferred cleanliness and order. The lack of related ecological knowledge and environmental awareness was the root cause of the lesser support towards NALA. To establish NALA demonstration bases and to intensify the publicity and education of NALA idea and related ecological knowledge could promote an increasing number of urban habitants actively participating in NALA construction.

  19. Integrierter Sprach- und Sachunterricht im Spanischkurs fuer Fortgeschrittene am Beispiel des Themas "La Emigracion actual" (Integrated Instruction in Language and Realia in the Advanced Spanish Course, with, as an Example, the Topic "The Present Emigration")

    Science.gov (United States)

    Christ, Ingeborg

    1975-01-01

    Advanced-level Spanish courses often lead outside everyday situations. Text, topic, language content and skill orientation form a complex of conditions for advanced learning. Consequences of significance for the learning process are discussed, with the topic "la emigracion actual" ("the present emigration") as a base. (Text is in German.) (IFS/WGA)

  20. Architecture Sustainability

    NARCIS (Netherlands)

    Avgeriou, Paris; Stal, Michael; Hilliard, Rich

    2013-01-01

    Software architecture is the foundation of software system development, encompassing a system's architects' and stakeholders' strategic decisions. A special issue of IEEE Software is intended to raise awareness of architecture sustainability issues and increase interest and work in the area. The fir

  1. Architectural geometry

    NARCIS (Netherlands)

    Pottmann, Helmut; Eigensatz, Michael; Vaxman, A.; Wallner, Johannes

    2015-01-01

    Around 2005 it became apparent in the geometry processing community that freeform architecture contains many problems of a geometric nature to be solved, and many opportunities for optimization which however require geometric understanding. This area of research, which has been called architectural

  2. 3D scanning and 3D printing as innovative technologies for fabricating personalized topical drug delivery systems.

    Science.gov (United States)

    Goyanes, Alvaro; Det-Amornrat, Usanee; Wang, Jie; Basit, Abdul W; Gaisford, Simon

    2016-07-28

    Acne is a multifactorial inflammatory skin disease with high prevalence. In this work, the potential of 3D printing to produce flexible personalised-shape anti-acne drug (salicylic acid) loaded devices was demonstrated by two different 3D printing (3DP) technologies: Fused Deposition Modelling (FDM) and stereolithography (SLA). 3D scanning technology was used to obtain a 3D model of a nose adapted to the morphology of an individual. In FDM 3DP, commercially produced Flex EcoPLA™ (FPLA) and polycaprolactone (PCL) filaments were loaded with salicylic acid by hot melt extrusion (HME) (theoretical drug loading - 2% w/w) and used as feedstock material for 3D printing. Drug loading in the FPLA-salicylic acid and PCL-salicylic acid 3D printed patches was 0.4% w/w and 1.2% w/w respectively, indicating significant thermal degradation of drug during HME and 3D printing. Diffusion testing in Franz cells using a synthetic membrane revealed that the drug loaded printed samples released printed as a nose-shape mask by FDM 3DP, but the PCL-salicylic acid filament was not. In the SLA printing process, the drug was dissolved in different mixtures of poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) (PEG) that were solidified by the action of a laser beam. SLA printing led to 3D printed devices (nose-shape) with higher resolution and higher drug loading (1.9% w/w) than FDM, with no drug degradation. The results of drug diffusion tests revealed that drug diffusion was faster than with the FDM devices, 229 and 291μg/cm(2) within 3h for the two formulations evaluated. In this study, SLA printing was the more appropriate 3D printing technology to manufacture anti-acne devices with salicylic acid. The combination of 3D scanning and 3D printing has the potential to offer solutions to produce personalised drug loaded devices, adapted in shape and size to individual patients.

  3. Human-competitive automatic topic indexing

    CERN Document Server

    Medelyan, Olena

    2009-01-01

    Topic indexing is the task of identifying the main topics covered by a document. These are useful for many purposes: as subject headings in libraries, as keywords in academic publications and as tags on the web. Knowing a document’s topics helps people judge its relevance quickly. However, assigning topics manually is labor intensive. This thesis shows how to generate them automatically in a way that competes with human performance. Three kinds of indexing are investigated: term assignment, a task commonly performed by librarians, who select topics from a controlled vocabulary; tagging, a popular activity of web users, who choose topics freely; and a new method of keyphrase extraction, where topics are equated to Wikipedia article names. A general two-stage algorithm is introduced that first selects candidate topics and then ranks them by significance based on their properties. These properties draw on statistical, semantic, domain-specific and encyclopedic knowledge. They are combined using a machine learn...

  4. Pinhão starch and coat extract as new natural cosmetic ingredients: Topical formulation stability and sensory analysis.

    Science.gov (United States)

    Daudt, Renata Moschini; Back, Patrícia Inês; Cardozo, Nilo Sérgio Medeiros; Marczak, Ligia Damasceno Ferreira; Külkamp-Guerreiro, Irene Clemes

    2015-12-10

    The objective of this study was to use pinhão derivatives, starch and coat extract, as new natural ingredients to develop cosmetic formulations. Two types of formulation, gel and emulgel, and their controls were developed. The formulations were characterized by stability studies using thermal stress. The parameters analyzed were resistance to centrifugation, pH, spreadability, rheology, content of phenolic compounds and antioxidant activity. Sensory analysis was also performed to verify the acceptability of the ingredients to potential consumers. The pH was kept the same after heating/freezing cycles for all formulations, and the formulations showed stability by resistance to centrifugation. The formulations did not induce any skin irritation or cutaneous pH alteration. The pinhão starch addition improved spreadability stability and increased viscosity when compared with control formulations. The pinhão coat extract used in these formulations is a good source of phenolic compounds and antioxidant activity. Moreover, sensory analysis indicates that the emulgel formulation is the best vehicle for adding pinhão starch and pinhão coat extract.

  5. Architectural Theatricality

    DEFF Research Database (Denmark)

    Tvedebrink, Tenna Doktor Olsen

    This PhD thesis is motived by a personal interest in the theoretical, practical and creative qualities of architecture. But also a wonder and curiosity about the cultural and social relations architecture represents through its occupation with both the sciences and the arts. Inspired by present...... initiatives in Aalborg Hospital to overcome patient undernutrition by refurbishing eating environments, this thesis engages in an investigation of the interior architectural qualities of patient eating environments. The relevance for this holistic perspective, synthesizing health, food and architecture...... environments and a knowledge gap therefore exists in present hospital designs. Consequently, the purpose of this thesis has been to investigate if any research-based knowledge exist supporting the hypothesis that the interior architectural qualities of eating environments influence patient food intake, health...

  6. Lab architecture

    Science.gov (United States)

    Crease, Robert P.

    2008-04-01

    There are few more dramatic illustrations of the vicissitudes of laboratory architecturethan the contrast between Building 20 at the Massachusetts Institute of Technology (MIT) and its replacement, the Ray and Maria Stata Center. Building 20 was built hurriedly in 1943 as temporary housing for MIT's famous Rad Lab, the site of wartime radar research, and it remained a productive laboratory space for over half a century. A decade ago it was demolished to make way for the Stata Center, an architecturally striking building designed by Frank Gehry to house MIT's computer science and artificial intelligence labs (above). But in 2004 - just two years after the Stata Center officially opened - the building was criticized for being unsuitable for research and became the subject of still ongoing lawsuits alleging design and construction failures.

  7. Digitally-Driven Architecture

    Directory of Open Access Journals (Sweden)

    Henriette Bier

    2014-07-01

    Full Text Available The shift from mechanical to digital forces architects to reposition themselves: Architects generate digital information, which can be used not only in designing and fabricating building components but also in embedding behaviours into buildings. This implies that, similar to the way that industrial design and fabrication with its concepts of standardisation and serial production influenced modernist architecture, digital design and fabrication influences contemporary architecture. While standardisation focused on processes of rationalisation of form, mass-customisation as a new paradigm that replaces mass-production, addresses non-standard, complex, and flexible designs. Furthermore, knowledge about the designed object can be encoded in digital data pertaining not just to the geometry of a design but also to its physical or other behaviours within an environment. Digitally-driven architecture implies, therefore, not only digitally-designed and fabricated architecture, it also implies architecture – built form – that can be controlled, actuated, and animated by digital means.In this context, this sixth Footprint issue examines the influence of digital means as pragmatic and conceptual instruments for actuating architecture. The focus is not so much on computer-based systems for the development of architectural designs, but on architecture incorporating digital control, sens­ing, actuating, or other mechanisms that enable buildings to inter­act with their users and surroundings in real time in the real world through physical or sensory change and variation.

  8. Using an Analogical Thinking Model as an Instructional Tool to Improve Student Cognitive Ability in Architecture Design Learning Process

    Science.gov (United States)

    Wu, Yun-Wu; Weng, Kuo-Hua

    2013-01-01

    Lack of creativity is a problem often plaguing students from design-related departments. Therefore, this study is intended to incorporate analogical thinking in the education of architecture design to enhance students' learning and their future career performance. First, this study explores the three aspects of architecture design curricula,…

  9. Information Systems for Enterprise Architecture

    Directory of Open Access Journals (Sweden)

    Oswaldo Moscoso Zea

    2014-03-01

    Full Text Available (Received: 2014/02/14 - Accepted: 2014/03/25Enterprise Architecture (EA has emerged as one of the most important topics to consider in Information System studies and has grown to become an essential business management activity to visualize and evaluate the future direction of a company. Nowadays in the market there are several software tools that support Enterprise Architects to work with EA. In order to decrease the risk of purchasing software tools that do not fulfill stakeholder´s needs is important to assess the software before making an investment. In this paper a literature review of the state of the art of EA will be done. Furthermore evaluation initiatives and existing information systems are analyzed which can support decision makers in the appropriate software tools for their companies.

  10. Women's Health Topics

    Science.gov (United States)

    ... Health Diabetes Healthy Aging Heart Health Mammograms Caregiving Menopause Pregnancy Safe Medication Use Other Topics like cosmetics and nutrition Other Resources womenshealth.gov Federal Citizen Information Center ...

  11. Advances in network systems architectures, security, and applications

    CERN Document Server

    Awad, Ali; Furtak, Janusz; Legierski, Jarosław

    2017-01-01

    This book provides the reader with a comprehensive selection of cutting–edge algorithms, technologies, and applications. The volume offers new insights into a range of fundamentally important topics in network architectures, network security, and network applications. It serves as a reference for researchers and practitioners by featuring research contributions exemplifying research done in the field of network systems. In addition, the book highlights several key topics in both theoretical and practical aspects of networking. These include wireless sensor networks, performance of TCP connections in mobile networks, photonic data transport networks, security policies, credentials management, data encryption for network transmission, risk management, live TV services, and multicore energy harvesting in distributed systems. .

  12. Method for producing components with internal architectures, such as micro-channel reactors, via diffusion bonding sheets

    Science.gov (United States)

    Alman, David E.; Wilson, Rick D.; Davis, Daniel L.

    2011-03-08

    This invention relates to a method for producing components with internal architectures, and more particularly, this invention relates to a method for producing structures with microchannels via the use of diffusion bonding of stacked laminates. Specifically, the method involves weakly bonding a stack of laminates forming internal voids and channels with a first generally low uniaxial pressure and first temperature such that bonding at least between the asperites of opposing laminates occurs and pores are isolated in interfacial contact areas, followed by a second generally higher isostatic pressure and second temperature for final bonding. The method thereby allows fabrication of micro-channel devices such as heat exchangers, recuperators, heat-pumps, chemical separators, chemical reactors, fuel processing units, and combustors without limitation on the fin aspect ratio.

  13. Designable architectures on nanoparticle surfaces: zirconium phosphate nanoplatelets as a platform for tetravalent metal and phosphonic acid assemblies.

    Science.gov (United States)

    Mosby, Brian M; Goloby, Mark; Díaz, Agustín; Bakhmutov, Vladimir; Clearfield, Abraham

    2014-03-11

    Surface-functionalized zirconium phosphate (ZrP) nanoparticles were synthesized using a combination of ion exchange and self-assembly techniques. The surface of ZrP was used as a platform to deposit tetravalent metal ions by direct ion exchange with the protons of the surface phosphate groups. Subsequently, phosphonic acids were attached to the metal ion layer, effectively functionalizing the ZrP nanoparticles. Use of axially oriented bisphosphonic acids led to the ability to build layer-by-layer assemblies from the nanoparticle surface. Varying the metal ion and ligand used allowed designable architectures to be synthesized on the nanoparticle surface. X-ray powder diffraction, XPS, electron microprobe, solid-state NMR, FTIR, and TGA were used to characterize the synthesized materials.

  14. Product Architecture Modularity Strategies

    DEFF Research Database (Denmark)

    Mikkola, Juliana Hsuan

    2003-01-01

    The focus of this paper is to integrate various perspectives on product architecture modularity into a general framework, and also to propose a way to measure the degree of modularization embedded in product architectures. Various trade-offs between modular and integral product architectures...... and how components and interfaces influence the degree of modularization are considered. In order to gain a better understanding of product architecture modularity as a strategy, a theoretical framework and propositions are drawn from various academic literature sources. Based on the literature review......, the following key elements of product architecture are identified: components (standard and new-to-the-firm), interfaces (standardization and specification), degree of coupling, and substitutability. A mathematical function, termed modularization function, is introduced to measure the degree of modularization...

  15. Topics in atomic physics

    CERN Document Server

    Burkhardt, Charles E

    2006-01-01

    The study of atomic physics propelled us into the quantum age in the early twentieth century and carried us into the twenty-first century with a wealth of new and, in some cases, unexplained phenomena. Topics in Atomic Physics provides a foundation for students to begin research in modern atomic physics. It can also serve as a reference because it contains material that is not easily located in other sources. A distinguishing feature is the thorough exposition of the quantum mechanical hydrogen atom using both the traditional formulation and an alternative treatment not usually found in textbooks. The alternative treatment exploits the preeminent nature of the pure Coulomb potential and places the Lenz vector operator on an equal footing with other operators corresponding to classically conserved quantities. A number of difficult to find proofs and derivations are included as is development of operator formalism that permits facile solution of the Stark effect in hydrogen. Discussion of the classical hydrogen...

  16. ARCHITECTURAL LARGE CONSTRUCTED ENVIRONMENT. MODELING AND INTERACTION USING DYNAMIC SIMULATIONS

    Directory of Open Access Journals (Sweden)

    P. Fiamma

    2012-09-01

    Full Text Available How to use for the architectural design, the simulation coming from a large size data model? The topic is related to the phase coming usually after the acquisition of the data, during the construction of the model and especially after, when designers must have an interaction with the simulation, in order to develop and verify their idea. In the case of study, the concept of interaction includes the concept of real time "flows". The work develops contents and results that can be part of the large debate about the current connection between "architecture" and "movement". The focus of the work, is to realize a collaborative and participative virtual environment on which different specialist actors, client and final users can share knowledge, targets and constraints to better gain the aimed result. The goal is to have used a dynamic micro simulation digital resource that allows all the actors to explore the model in powerful and realistic way and to have a new type of interaction in a complex architectural scenario. On the one hand, the work represents a base of knowledge that can be implemented more and more; on the other hand the work represents a dealt to understand the large constructed architecture simulation as a way of life, a way of being in time and space. The architectural design before, and the architectural fact after, both happen in a sort of "Spatial Analysis System". The way is open to offer to this "system", knowledge and theories, that can support architectural design work for every application and scale. We think that the presented work represents a dealt to understand the large constructed architecture simulation as a way of life, a way of being in time and space. Architecture like a spatial configuration, that can be reconfigurable too through designing.

  17. Architectural technology

    DEFF Research Database (Denmark)

    2005-01-01

    The booklet offers an overall introduction to the Institute of Architectural Technology and its projects and activities, and an invitation to the reader to contact the institute or the individual researcher for further information. The research, which takes place at the Institute of Architectural...... Technology at the Roayl Danish Academy of Fine Arts, School of Architecture, reflects a spread between strategic, goal-oriented pilot projects, commissioned by a ministry, a fund or a private company, and on the other hand projects which originate from strong personal interests and enthusiasm of individual...

  18. Architecture and Bureaucracy: The Quirinal as an Expression of Papal Absolutism

    NARCIS (Netherlands)

    Witte, A.

    2014-01-01

    The Quirinal Palace, nowadays mostly regarded as the seat of Italy’s republican government, was built between the late sixteenth and late eighteenth century as the new seat of papal power. It started out as a summer retreat, but soon was provided with all the necessary spaces for official receptions

  19. Meet French Architecture in China

    Institute of Scientific and Technical Information of China (English)

    Susan

    2005-01-01

    On April 5, a French architectural exhibition entitled ""French Visions: City, Architecture and Sustainable Development"" was unveiled in Beijing Urban Planning Center. As a key exhibition within the framework of French Year in China, the exhibition will also be displayed in Shanghai and Chongqing. The largest exhibition of its kind ever held in China, French Visions extensively showed accomplishments of contemporary French architectural design.

  20. Enterprise Architecture as a Way of Synchronizing Enterprise Resource Planning Systems and Business Processes

    DEFF Research Database (Denmark)

    Johansson, Björn; Holst, Philip; Henningsson, Stefan

    2009-01-01

    A major question for contemporary organizations is how to support business processes with ICT. One way to do so is by the adoption of a standardized software package such as enterprise resource planning (ERP) systems. However, this demands that either the system is adjusted to existing business...... processes or that the business processes are adjusted to the system’s inherited processes, often described as an alignment problem. This paper suggests that instead of alignment, organization-technology synchronization would be better, since an organization’s business processes as well as the technology...

  1. Topic Identification in Discourse

    CERN Document Server

    Chen, K

    1995-01-01

    This paper proposes a corpus-based language model for topic identification. We analyze the association of noun-noun and noun-verb pairs in LOB Corpus. The word association norms are based on three factors: 1) word importance, 2) pair co-occurrence, and 3) distance. They are trained on the paragraph and sentence levels for noun-noun and noun-verb pairs, respectively. Under the topic coherence postulation, the nouns that have the strongest connectivities with the other nouns and verbs in the discourse form the preferred topic set. The collocational semantics then is used to identify the topics from paragraphs and to discuss the topic shift phenomenon among paragraphs.

  2. An SDN-based architecture for Network-as-a-Service

    NARCIS (Netherlands)

    Manthena, M.P.V. van; Adrichem, N.L.M.; Broek, C. van den; Kuipers, F.

    2015-01-01

    Network-as-a-Service (NaaS) is a cloud-based service model that offers on-demand network connectivity and the provisioning and management of network services. However, the actual orchestration of dynamically allocating underlying resources to customer requirements is not trivial. In this paper, we p

  3. PREFACE: CEWQO Topical Issue CEWQO Topical Issue

    Science.gov (United States)

    Bozic, Mirjana; Man'ko, Margarita

    2009-09-01

    This topical issue of Physica Scripta collects selected peer-reviewed contributions based on invited and contributed talks and posters presented at the 15th Central European Workshop on Quantum Optics (CEWQO) which took place in Belgrade 29 May-3 June 2008 (http://cewqo08.phy.bg.ac.yu). On behalf of the whole community took place in Belgrade 29 May-3 June 2008 (http://cewqo08.phy.bg.ac.yu, cewqo08.phy.bg.ac.yu). On behalf of the whole community of the workshop, we thank the referees for their careful reading and useful suggestions which helped to improve all of the submitted papers. A brief description of CEWQO The Central European Workshop on Quantum Optics is a series of conferences started informally in Budapest in 1992. Sometimes small events transform into important conferences, as in the case of CEWQO. Professor Jozsef Janszky, from the Research Institute of Solid State Physics and Optics, is the founder of this series. Margarita Man'ko obtained the following information from Jozsef Janszky during her visit to Budapest, within the framework of cooperation between the Russian and Hungarian Academies of Sciences in 2005. He organized a small workshop on quantum optics in Budapest in 1992 with John Klauder as a main speaker. Then, bearing in mind that a year before Janszky himself was invited by Vladimir Buzek to give a seminar on the same topic in Bratislava, he decided to assign the name 'Central European Workshop on Quantum Optics', considering the seminar in Bratislava to be the first workshop and the one in Budapest the second. The third formal workshop took place in Bratislava in 1993 organized by Vladimir Buzek, then in 1994 (Budapest, by Jozsef Janszky), 1995 and 1996 (Budmerice, Slovakia, by Vladimir Buzek), 1997 (Prague, by Igor Jex), 1999 (Olomouc, Czech Republic, by Zdenek Hradil), 2000 (Balatonfüred, Hungary, by Jozsef Janszky ), 2001 (Prague, by Igor Jex), 2002 (Szeged, Hungary, by Mihaly Benedict), 2003 (Rostock,Germany, by Werner Vogel and

  4. The fractal globule as a model of chromatin architecture in the cell

    OpenAIRE

    Mirny, Leonid A.

    2011-01-01

    The fractal globule is a compact polymer state that emerges during polymer condensation as a result of topological constraints which prevent one region of the chain from passing across another one. This long-lived intermediate state was introduced in 1988 (Grosberg et al. 1988) and has not been observed in experiments or simulations until recently (Lieberman-Aiden et al. 2009). Recent characterization of human chromatin using a novel chromosome conformational capture technique brought the fra...

  5. A Survey of Topic Modeling in Text Mining

    Directory of Open Access Journals (Sweden)

    Rubayyi Alghamdi

    2015-01-01

    Full Text Available Topic models provide a convenient way to analyze large of unclassified text. A topic contains a cluster of words that frequently occur together. A topic modeling can connect words with similar meanings and distinguish between uses of words with multiple meanings. This paper provides two categories that can be under the field of topic modeling. First one discusses the area of methods of topic modeling, which has four methods that can be considerable under this category. These methods are Latent semantic analysis (LSA, Probabilistic latent semantic analysis (PLSA, Latent Dirichlet allocation (LDA, and Correlated topic model (CTM. The second category is called topic evolution models, which model topics by considering an important factor time. In the second category, different models are discussed, such as topic over time (TOT, dynamic topic models (DTM, multiscale topic tomography, dynamic topic correlation detection, detecting topic evolution in scientific literature, etc.

  6. Universal Design as a Booster for Housing Quality and Architectural Practice.

    Science.gov (United States)

    Denizou, Karine

    2016-01-01

    Norwegian central government has for the last decade increasingly focused on universal design. Fundamental changes in the Norwegian building code and corresponding regulations in 2010 give an apparently clear framework for the implementation of accessibility and universal design. However, it seems that neither increased awareness of accessibility requirements and universal design, nor compliance with the building code guarantees improvement of housing quality and usability. The Norwegian regulations have gone further in the direction of performance requirements than most other countries. This applies to all types of requirements, including requirements for usability, functionality and accessibility. Hardly any specifications are to be found in the regulations. Ideally, this lack of specifications should give designers the opportunity to develop innovative answers and hence to respond to different contexts and needs. Still, many architects and builders ask for clear specifications, in order to simplify and speed up design processes and make control of solutions easier. Many architects understand guidelines as minimum requirements, and are thus reproducing the identical solutions without considering the context and the needs of the users. They see accessibility as another regulatory pressure and requirements as restrictions rather than positive incentives. However, there are examples of designers who have internalised the regulatory framework and thus are able to create and integrate inclusive design in their daily work. Based on recent research conducted by SINTEF Building and Infrastructure and financed by the Norwegian State Housing Bank, this paper presents examples of practice where dwellings have been developed within a framework of universal design. Focus of the research has been on the approach of the design team and their understanding and use of the regulatory framework in order to create better homes in dialogue with the building authorities. Main

  7. Art and architecture as experience: an alternative approach to bridging art history and the neurosciences.

    Science.gov (United States)

    Zschocke, Nina

    2012-08-01

    In 1972, Michael Baxandal characterizes the processes responsible for the cultural relativism of art experience as highly complex and unknown in their physiological detail. While art history still shows considerable interest in the brain sciences forty years later, most cross-disciplinary studies today are referring to the neurosciences in an attempt to seek scientific legitimization of variations of a generalized and largely deterministic model of perception, reducing interaction between a work of art and its observers to a set of biological automatisms. I will challenge such an approach and take up art theory's interest in the historico-cultural and situational dimensions of art experience. Looking at two examples of large-scale installation and sculptural post-war American art, I will explore instable perceptions of depth and changing experiences of space that indicate complex interactions between perceptual and higher cognitive processes. The argument will draw on recent theories describing neuronal processes underlying multistable phenomena, eye movement, visual attention and decision-making. As I will show a large number of neuroscientific studies provide theoretical models that help us analyse not the anthropological constants but the influence of cultural, individual and situational variables on aesthetic experience.

  8. A Systematic Mapping Study of Software Architectures for Cloud Based Systems

    DEFF Research Database (Denmark)

    Chauhan, Muhammad Aufeef; Babar, Muhammad Ali

    2014-01-01

    Context: Cloud computing has gained significant attention of researchers and practitioners. This emerging paradigm is being used to provide solutions in multiple domains without huge upfront investment because of its on demand recourse-provisioning model. However, the information about how software...... of this study is to systematically identify and analyze the currently published research on the topics related to software architectures for cloud-based systems in order to identify architecture solutions for achieving quality requirements. Method: We decided to carry out a systematic mapping study to find...... as much peer-reviewed literature on the topics related to software architectures for cloud-based systems as possible. This study has been carried out by following the guidelines for conducting systematic literature reviews and systematic mapping studies as reported in the literature. Based on our paper...

  9. Modification of leaf morphology and anatomy as a consequence of columnar architecture in domestic apple (Malus x domestica Borkh.) trees

    DEFF Research Database (Denmark)

    Talwara, Susheela; Grout, Brian William Wilson; Toldam-Andersen, Torben Bo

    2013-01-01

    A quantitative study has been made of the modifications to leaf morphology and anatomy evident in columnar apples trees when compared to standard ones, using the original cultivar and the first columnar mutant derived from it, as well as other closely and more distantly related cultivars. Signifi......A quantitative study has been made of the modifications to leaf morphology and anatomy evident in columnar apples trees when compared to standard ones, using the original cultivar and the first columnar mutant derived from it, as well as other closely and more distantly related cultivars....... Significant increases in leaf number, area, weight per unit area, thickness and midrib angle, together with altered shape, have been recorded consistently for the leaves subtending the developing fruits of the columnar cultivars. Additionally, significant increases in leaf rolling, epicuticular wax, stomatal...... of leaf characteristics is considered in terms of the very open architectural phenotype of columnar trees and the impact this may have on the canopy microclimate that influences leaf development....

  10. An Empirical Study on Ncomputing as an Architecture That Changes the Green Equation.

    Directory of Open Access Journals (Sweden)

    Sadaqat Husain Ansari

    2014-05-01

    Full Text Available As we know very well that in present days, computer is the basic need of every common man and they have to use it for time saving and to minimize human labour, rather than they also need to aware about its harmful impacts on the environment. In this research paper we take various factors related to the awareness of green computing. Present desktop computers gives extremely powerful performance since they are equipped with blazing 2 GHz dual-core or core to duo processors and high-performance memory. However, mostly users rarely need the capacity of operation more than 5 percent of available computing capacity – the rest is wasted. It would be possible to achieve significant environment and cost savings by sharing this excess or waste power by many users simultaneously. NComputing seized on this idea by which minimize the power consumption. Power consumption by the computers is the major issue in current industries and data centres.

  11. Amphibians as Model Organisms for Studying the Dynamics of Eukaryote Genetic Material Architecture

    Directory of Open Access Journals (Sweden)

    Burlibaşa, L.

    2005-06-01

    Full Text Available Amphibians have played a key role in the elucidation of the mechanisms of early development over the last century. Much of our knowledge about the mechanisms of vertebrate early development comes from studies using Xenopus laevis. Xenopus sp. is a major contributor to our understanding of cell biological and biochemical processes, including: (1 chromosome replication; (2 chromatin, cytoskeleton and nuclear assembly; (3 cell cycle progression and (4 intracellular signaling. Amphibian embryos remained the embryos of choice for experimental embryology for many decades. European embryologists used predominantly urodele embryos (such as Triturus and embryos of the frog Rana temporaria, which is related to the North American species Rana pipiens. Using light, fluorescence, transmission electron microscopy (TEM and molecular investigations, some peculiar aspects of chromatin and chromosome organization and evolution in oogenesis and spermatogenesis of amphibians were investigated. We have focused our investigations on dynamics of the chromatin structure in different stages of development.

  12. Design of Decorated Self-Assembling Peptide Hydrogels as Architecture for Mesenchymal Stem Cells

    Directory of Open Access Journals (Sweden)

    Annj Zamuner

    2016-08-01

    Full Text Available Hydrogels from self-assembling ionic complementary peptides have been receiving a lot of interest from the scientific community as mimetic of the extracellular matrix that can offer three-dimensional supports for cell growth or can become vehicles for the delivery of stem cells, drugs or bioactive proteins. In order to develop a 3D “architecture” for mesenchymal stem cells, we propose the introduction in the hydrogel of conjugates obtained by chemoselective ligation between a ionic-complementary self-assembling peptide (called EAK and three different bioactive molecules: an adhesive sequence with 4 Glycine-Arginine-Glycine-Aspartic Acid-Serine-Proline (GRGDSP motifs per chain, an adhesive peptide mapped on h-Vitronectin and the growth factor Insulin-like Growth Factor-1 (IGF-1. The mesenchymal stem cell adhesion assays showed a significant increase in adhesion and proliferation for the hydrogels decorated with each of the synthesized conjugates; moreover, such functionalized 3D hydrogels support cell spreading and elongation, validating the use of this class of self-assembly peptides-based material as very promising 3D model scaffolds for cell cultures, at variance of the less realistic 2D ones. Furthermore, small amplitude oscillatory shear tests showed that the presence of IGF-1-conjugate did not alter significantly the viscoelastic properties of the hydrogels even though differences were observed in the nanoscale structure of the scaffolds obtained by changing their composition, ranging from long, well-defined fibers for conjugates with adhesion sequences to the compact and dense film for the IGF-1-conjugate.

  13. RECONSTRUCTING DECONSTRUCTION IN ARCHITECTURE

    Directory of Open Access Journals (Sweden)

    IDHAM Noor Cholis

    2013-12-01

    Full Text Available This paper examines deconstruction in architecture and forms used, which triggered by dispute of form and its scientification claimed by deconstructivists. Deconstruction terminologyis studied in the first part related to architecture field as a base knowledge. Some sample works of known deconstructionist architects are assessed in order to understand how their building is deconstructed and what forms they used. Discussion about form and its relation to other fields is then pursued by discussing the involvement of terminology of science, aesthetic pattern, and human life. The results of this discussion give clear understanding how form related to deconstruction in architecture are used.

  14. Towards Adaptive Evolutionary Architecture

    DEFF Research Database (Denmark)

    Bak, Sebastian HOlt; Rask, Nina; Risi, Sebastian

    2016-01-01

    This paper presents first results from an interdisciplinary project, in which the fields of architecture, philosophy and artificial life are combined to explore possible futures of architecture. Through an interactive evolutionary installation, called EvoCurtain, we investigate aspects of how...... to the development of designs tailored to the individual preferences of inhabitants, changing the roles of architects and designers entirely. Architecture-as-it-could-be is a philosophical approach conducted through artistic methods to anticipate the technological futures of human-centered development within...

  15. Fractal Geometry of Architecture

    Science.gov (United States)

    Lorenz, Wolfgang E.

    In Fractals smaller parts and the whole are linked together. Fractals are self-similar, as those parts are, at least approximately, scaled-down copies of the rough whole. In architecture, such a concept has also been known for a long time. Not only architects of the twentieth century called for an overall idea that is mirrored in every single detail, but also Gothic cathedrals and Indian temples offer self-similarity. This study mainly focuses upon the question whether this concept of self-similarity makes architecture with fractal properties more diverse and interesting than Euclidean Modern architecture. The first part gives an introduction and explains Fractal properties in various natural and architectural objects, presenting the underlying structure by computer programmed renderings. In this connection, differences between the fractal, architectural concept and true, mathematical Fractals are worked out to become aware of limits. This is the basis for dealing with the problem whether fractal-like architecture, particularly facades, can be measured so that different designs can be compared with each other under the aspect of fractal properties. Finally the usability of the Box-Counting Method, an easy-to-use measurement method of Fractal Dimension is analyzed with regard to architecture.

  16. Transformation as a Design Process and Runtime Architecture for High Integrity Software

    Energy Technology Data Exchange (ETDEWEB)

    Bespalko, S.J.; Winter, V.L.

    1999-04-05

    We have discussed two aspects of creating high integrity software that greatly benefit from the availability of transformation technology, which in this case is manifest by the requirement for a sophisticated backtracking parser. First, because of the potential for correctly manipulating programs via small changes, an automated non-procedural transformation system can be a valuable tool for constructing high assurance software. Second, modeling the processing of translating data into information as a, perhaps, context-dependent grammar leads to an efficient, compact implementation. From a practical perspective, the transformation process should begin in the domain language in which a problem is initially expressed. Thus in order for a transformation system to be practical it must be flexible with respect to domain-specific languages. We have argued that transformation applied to specification results in a highly reliable system. We also attempted to briefly demonstrate that transformation technology applied to the runtime environment will result in a safe and secure system. We thus believe that the sophisticated multi-lookahead backtracking parsing technology is central to the task of being in a position to demonstrate the existence of HIS.

  17. Peripheral Female Genital Arousal as Assessed by Thermography Following Topical Genital Application of Alprostadil vs Placebo Arousal Gel: A Proof-of-Principle Study Without Visual Sexual Stimulation

    Directory of Open Access Journals (Sweden)

    Sue W. Goldstein, BA, CCRC, IF

    2016-09-01

    Conclusion: Topical alprostadil administered to healthy premenopausal women induced statistically significant, sustained increases in genital temperatures of the vestibule, clitoris, and vulva within 20 minutes compared with OTC lubricant.

  18. Topics in current aerosol research

    CERN Document Server

    Hidy, G M

    1971-01-01

    Topics in Current Aerosol Research deals with the fundamental aspects of aerosol science, with emphasis on experiment and theory describing highly dispersed aerosols (HDAs) as well as the dynamics of charged suspensions. Topics covered range from the basic properties of HDAs to their formation and methods of generation; sources of electric charges; interactions between fluid and aerosol particles; and one-dimensional motion of charged cloud of particles. This volume is comprised of 13 chapters and begins with an introduction to the basic properties of HDAs, followed by a discussion on the form

  19. Topics in millimeter wave technology

    CERN Document Server

    Button, Kenneth

    1988-01-01

    Topics in Millimeter Wave Technology, Volume 1 presents topics related to millimeter wave technology, including fin-lines and passive components realized in fin-lines, suspended striplines, suspended substrate microstrips, and modal power exchange in multimode fibers. A miniaturized monopulse assembly constructed in planar waveguide with multimode scalar horn feeds is also described. This volume is comprised of five chapters; the first of which deals with the analysis and synthesis techniques for fin-lines as well as the various passive components realized in fin-line. Tapers, discontinuities,

  20. Identifying Topics in Microblogs Using Wikipedia.

    Science.gov (United States)

    Yıldırım, Ahmet; Üsküdarlı, Suzan; Özgür, Arzucan

    2016-01-01

    Twitter is an extremely high volume platform for user generated contributions regarding any topic. The wealth of content created at real-time in massive quantities calls for automated approaches to identify the topics of the contributions. Such topics can be utilized in numerous ways, such as public opinion mining, marketing, entertainment, and disaster management. Towards this end, approaches to relate single or partial posts to knowledge base items have been proposed. However, in microblogging systems like Twitter, topics emerge from the culmination of a large number of contributions. Therefore, identifying topics based on collections of posts, where individual posts contribute to some aspect of the greater topic is necessary. Models, such as Latent Dirichlet Allocation (LDA), propose algorithms for relating collections of posts to sets of keywords that represent underlying topics. In these approaches, figuring out what the specific topic(s) the keyword sets represent remains as a separate task. Another issue in topic detection is the scope, which is often limited to specific domain, such as health. This work proposes an approach for identifying domain-independent specific topics related to sets of posts. In this approach, individual posts are processed and then aggregated to identify key tokens, which are then mapped to specific topics. Wikipedia article titles are selected to represent topics, since they are up to date, user-generated, sophisticated articles that span topics of human interest. This paper describes the proposed approach, a prototype implementation, and a case study based on data gathered during the heavily contributed periods corresponding to the four US election debates in 2012. The manually evaluated results (0.96 precision) and other observations from the study are discussed in detail.

  1. Software architecture for time-constrained machine vision applications

    Science.gov (United States)

    Usamentiaga, Rubén; Molleda, Julio; García, Daniel F.; Bulnes, Francisco G.

    2013-01-01

    Real-time image and video processing applications require skilled architects, and recent trends in the hardware platform make the design and implementation of these applications increasingly complex. Many frameworks and libraries have been proposed or commercialized to simplify the design and tuning of real-time image processing applications. However, they tend to lack flexibility, because they are normally oriented toward particular types of applications, or they impose specific data processing models such as the pipeline. Other issues include large memory footprints, difficulty for reuse, and inefficient execution on multicore processors. We present a novel software architecture for time-constrained machine vision applications that addresses these issues. The architecture is divided into three layers. The platform abstraction layer provides a high-level application programming interface for the rest of the architecture. The messaging layer provides a message-passing interface based on a dynamic publish/subscribe pattern. A topic-based filtering in which messages are published to topics is used to route the messages from the publishers to the subscribers interested in a particular type of message. The application layer provides a repository for reusable application modules designed for machine vision applications. These modules, which include acquisition, visualization, communication, user interface, and data processing, take advantage of the power of well-known libraries such as OpenCV, Intel IPP, or CUDA. Finally, the proposed architecture is applied to a real machine vision application: a jam detector for steel pickling lines.

  2. Architectural geometry

    KAUST Repository

    Pottmann, Helmut

    2014-11-26

    Around 2005 it became apparent in the geometry processing community that freeform architecture contains many problems of a geometric nature to be solved, and many opportunities for optimization which however require geometric understanding. This area of research, which has been called architectural geometry, meanwhile contains a great wealth of individual contributions which are relevant in various fields. For mathematicians, the relation to discrete differential geometry is significant, in particular the integrable system viewpoint. Besides, new application contexts have become available for quite some old-established concepts. Regarding graphics and geometry processing, architectural geometry yields interesting new questions but also new objects, e.g. replacing meshes by other combinatorial arrangements. Numerical optimization plays a major role but in itself would be powerless without geometric understanding. Summing up, architectural geometry has become a rewarding field of study. We here survey the main directions which have been pursued, we show real projects where geometric considerations have played a role, and we outline open problems which we think are significant for the future development of both theory and practice of architectural geometry.

  3. Advanced Topics in Aerodynamics

    DEFF Research Database (Denmark)

    Filippone, Antonino

    1999-01-01

    "Advanced Topics in Aerodynamics" is a comprehensive electronic guide to aerodynamics,computational fluid dynamics, aeronautics, aerospace propulsion systems, design and relatedtechnology. We report data, tables, graphics, sketches,examples, results, photos, technical andscientific literature...

  4. Supplemental topics on voids

    Energy Technology Data Exchange (ETDEWEB)

    Rood, H.J.

    1988-09-01

    Several topics concerning voids are presented, supplementing the report of Rood (1988). The discovery of the Coma supercluster and void and the recognition of the cosmological significance of superclusters and voids are reviewed. Galaxy redshift surveys and redshift surveys for the Abell clusters and very distant objects are discussed. Solar system and extragalactic dynamics are examined. Also, topics for future observational research on voids are recommended. 50 references.

  5. Parent's alcoholism severity and family topic avoidance about alcohol as predictors of perceived stigma among adult children of alcoholics: Implications for emotional and psychological resilience.

    Science.gov (United States)

    Haverfield, Marie C; Theiss, Jennifer A

    2016-01-01

    Alcoholism is a highly stigmatized condition, with both alcohol-dependent individuals and family members of the afflicted experiencing stigmatization. This study examined the severity of a parent's alcoholism and family topic avoidance about alcohol as two factors that are associated with family members' perceptions of stigma. Three dimensions of stigma were considered: discrimination stigma, disclosure stigma, and positive aspect stigma. In addition, this study assessed associations between perceived stigmatization and individuals' experiences of depressive symptoms, self-esteem, and resilience. Adult children of alcoholics (N = 622) were surveyed about family conditions, perceived stigma, and their emotional and psychological well-being. Regression analyses revealed that the severity of a parent's alcoholism predicted all three types of stigma for females, but not for males. In addition, family topic avoidance about alcohol predicted all types of stigma for males and discrimination stigma and positive aspect stigma for females. With few exceptions, the three types of stigma predicted depressive symptoms, self-esteem, and resilience for both male and female adult children of alcoholics. The results are discussed in terms of their implications for promoting a family environment that mitigates stigma and encourages emotional and psychological well-being. In 2012, approximately 3.3 million deaths worldwide were due to the harmful use of alcohol (World Health Organization [WHO], 2014). Individuals who abuse alcohol are susceptible to a variety of negative health outcomes (Rehm et al., 2009) and display inappropriate social behaviors (Klingemann, 2001; Schomerus et al., 2011a). General societal perceptions tend to characterize alcohol-dependent individuals as irresponsible and lacking in self-control (Schomerus et al., 2011b). Research in the United Kingdom found that 54% of the population believes alcohol-dependent individuals are personally to blame for their own

  6. Cellular architecture of Treponema pallidum: novel flagellum, periplasmic cone, and cell envelope as revealed by cryo electron tomography.

    Science.gov (United States)

    Liu, Jun; Howell, Jerrilyn K; Bradley, Sherille D; Zheng, Yesha; Zhou, Z Hong; Norris, Steven J

    2010-11-01

    High-resolution cryo electron tomography (cryo-ET) was utilized to visualize Treponema pallidum, the causative agent of syphilis, at the molecular level. Three-dimensional (3D) reconstructions from 304 infectious organisms revealed unprecedented cellular structures of this unusual member of the spirochetal family. High-resolution cryo-ET reconstructions provided detailed structures of the cell envelope, which is significantly different from that of Gram-negative bacteria. The 4-nm lipid bilayer of both outer membrane and cytoplasmic membrane resolved in 3D reconstructions, providing an important marker for interpreting membrane-associated structures. Abundant lipoproteins cover the outer leaflet of the cytoplasmic membrane, in contrast to the rare outer membrane proteins visible by scanning probe microscopy. High-resolution cryo-ET images also provided the first observation of T. pallidum chemoreceptor arrays, as well as structural details of the periplasmically located cone-shaped structure at both ends of the bacterium. Furthermore, 3D subvolume averages of periplasmic flagellar motors and flagellar filaments from living organisms revealed the novel flagellar architectures that may facilitate their rotation within the confining periplasmic space. Our findings provide the most detailed structural understanding of periplasmic flagella and the surrounding cell envelope, which enable this enigmatic bacterium to efficiently penetrate tissue and to escape host immune responses.

  7. Rapid changes in shape and cell architecture of isolated fragments of amphibian embryonic tissues as an experimental model of morphogenesis.

    Science.gov (United States)

    Belousov, L V; Dorfman, Y G; Cherdantsev, V G

    1975-07-01

    Changes in the shape and cell architecture of pieces of epithelial and neural ectoderm, mesoderm, neural tube, and combined ectomesodermal fragments from embryos of Rana temporaria 0-60 min after isolation were studied. The fragments were capable of changing their shape quickly (actually during separation) or after a latent period of several minutes. Rapid deformations were not prevented by cooling or by moderate doses of cyanide; as a rule they were connected with contraction of the surface area of the cells of the fragment and they can be regarded as relaxation to forms with lower mechanical energy. The direction of the deformation usually coincides with the subsequent normal morphogenesis of the particular anlage. Deformations with a latent period are suppressed by cooling and by the addition of cyanide, which lead to an increase in the surface area of individual cells, but they reduce the total surface area of the fragment. The shape of the fragments becomes more complex: they become irregularly twisted, they form folds, and they separate into spherical regions with stretched surfaces ("drops"). These processes are connected with the performance of positive mechanical work by the intracellular contractile systems. The reasons why the fragments become more complex in shape are discussed.

  8. THE EMERGENCE AND EVOLUTION OF ARABESQUE AS A MULTICULTURAL STYLISTIC FUSION IN ISLAMIC ART: THE CASE OF TURKISH ARCHITECTURE

    Directory of Open Access Journals (Sweden)

    Murat Cetin, M. Arif Kamal

    2012-04-01

    Full Text Available This paper elucidates the emergence and evolution of arabesque with specific reference to  the case of arabesque in Turkish art and architecture. It is argued here that arabesque is a fusion of styles rather than a pure and homogenous style. Furthermore, the paper aims to show that although the arabesque style appears to be a fanciful and freely organized manner of artistic treatment it is based on a very complex mathematical logic which is expressed through abstractionism. In this context, the grammar of geometry is elaborately used in the  implementation  of abstraction. Here, general characteristics as well as different modes or  types  of arabesque are discussed. Starting with the etymological roots of the term, the  history of its use in the literature  is  explored  through  the  paper. After  the  inquiry  of  its  material  and  pragmatic  aspects,  the development of the arabesque style is evaluated with regard to its transformations that took place along with its injection to Anatolia and mixing with Turkish culture. Finally, the morphological character of this fusion is put forward.   Keyword: Morphological character, geometry, fusion of styles, arabesque

  9. Topical treatment of melasma

    Directory of Open Access Journals (Sweden)

    Bandyopadhyay Debabrata

    2009-01-01

    Full Text Available Melasma is a common hypermelanotic disorder affecting the face that is associated with considerable psychological impacts. The management of melasma is challenging and requires a long-term treatment plan. In addition to avoidance of aggravating factors like oral pills and ultraviolet exposure, topical therapy has remained the mainstay of treatment. Multiple options for topical treatment are available, of which hydroquinone (HQ is the most commonly prescribed agent. Besides HQ, other topical agents for which varying degrees of evidence for clinical efficacy exist include azelaic acid, kojic acid, retinoids, topical steroids, glycolic acid, mequinol, and arbutin. Topical medications modify various stages of melanogenesis, the most common mode of action being inhibition of the enzyme, tyrosinase. Combination therapy is the preferred mode of treatment for the synergism and reduction of untoward effects. The most popular combination consists of HQ, a topical steroid, and retinoic acid. Prolonged HQ usage may lead to untoward effects like depigmentation and exogenous ochronosis. The search for safer alternatives has given rise to the development of many newer agents, several of them from natural sources. Well-designed controlled clinical trials are needed to clarify their role in the routine management of melasma.

  10. TOPICAL TREATMENT OF MELASMA

    Science.gov (United States)

    Bandyopadhyay, Debabrata

    2009-01-01

    Melasma is a common hypermelanotic disorder affecting the face that is associated with considerable psychological impacts. The management of melasma is challenging and requires a long-term treatment plan. In addition to avoidance of aggravating factors like oral pills and ultraviolet exposure, topical therapy has remained the mainstay of treatment. Multiple options for topical treatment are available, of which hydroquinone (HQ) is the most commonly prescribed agent. Besides HQ, other topical agents for which varying degrees of evidence for clinical efficacy exist include azelaic acid, kojic acid, retinoids, topical steroids, glycolic acid, mequinol, and arbutin. Topical medications modify various stages of melanogenesis, the most common mode of action being inhibition of the enzyme, tyrosinase. Combination therapy is the preferred mode of treatment for the synergism and reduction of untoward effects. The most popular combination consists of HQ, a topical steroid, and retinoic acid. Prolonged HQ usage may lead to untoward effects like depigmentation and exogenous ochronosis. The search for safer alternatives has given rise to the development of many newer agents, several of them from natural sources. Well-designed controlled clinical trials are needed to clarify their role in the routine management of melasma. PMID:20101327

  11. Maps on the basis of the Arts & Humanities Citation Index: The journals Leonardo and Art Journal versus "Digital Humanities" as a topic

    CERN Document Server

    Leydesdorff, Loet

    2009-01-01

    The possibilities of using the Arts & Humanities Citation Index (A&HCI) for journal mapping have not been sufficiently recognized because of the absence of a Journal Citations Report (JCR) for this database. A quasi-JCR for the A&HCI (2008) was constructed from the data contained in the Web-of-Science and is used for the evaluation of two journals as examples: Leonardo and Art Journal. The maps on the basis of the aggregated journal-journal citations within this domain can be compared with maps including references to journals in the Science Citation Index and Social Science Citation Index. Art journals are cited by (social) science journals more than by other art journals, but these journals draw upon one another in terms of their own references. This cultural impact in terms of being cited is not found when documents with a topic such as "digital humanities" are analyzed. This community of practice functions more as an intellectual organizer than a journal.

  12. Towards an Operational Framework for Architectural Prototyping

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak

    2005-01-01

    We use a case study in architectural prototyping as input for presenting a first, tentative, framework describing key concepts and their relationships in architectural prototyping processes.......We use a case study in architectural prototyping as input for presenting a first, tentative, framework describing key concepts and their relationships in architectural prototyping processes....

  13. Architecture Descriptions. A Contribution to Modeling of Production System Architecture

    DEFF Research Database (Denmark)

    Jepsen, Allan Dam; Hvam, Lars

    on the underlying principles of a production system’s design; and despite the existence of established architecture and platform theories and practices within product design, there is still a need for a better understanding of the architecture phenomenon itself, and certainly how it applies within production system....... The viewpoints provide a set of model kinds to frame select architecture related concerns relating to the production capability and the design of the technical system. With the contribution to architecture description there follows a need to support exchange and processing of architecture information within......The subject of this PhD dissertation is architecture-centric design and the description of production system architecture. Companies are facing demands for the development and production of new products at an ever increasing rate, as the market life of products decreases and the rate at which...

  14. Robot Electronics Architecture

    Science.gov (United States)

    Garrett, Michael; Magnone, Lee; Aghazarian, Hrand; Baumgartner, Eric; Kennedy, Brett

    2008-01-01

    An electronics architecture has been developed to enable the rapid construction and testing of prototypes of robotic systems. This architecture is designed to be a research vehicle of great stability, reliability, and versatility. A system according to this architecture can easily be reconfigured (including expanded or contracted) to satisfy a variety of needs with respect to input, output, processing of data, sensing, actuation, and power. The architecture affords a variety of expandable input/output options that enable ready integration of instruments, actuators, sensors, and other devices as independent modular units. The separation of different electrical functions onto independent circuit boards facilitates the development of corresponding simple and modular software interfaces. As a result, both hardware and software can be made to expand or contract in modular fashion while expending a minimum of time and effort.

  15. Cloud computing for enterprise architectures

    CERN Document Server

    Mahmood, Zaigham

    2011-01-01

    This important text provides a single point of reference for state-of-the-art cloud computing design and implementation techniques. The book examines cloud computing from the perspective of enterprise architecture, asking the question; how do we realize new business potential with our existing enterprises? Its topics and features are: with a Foreword by Thomas Erl; contains contributions from an international selection of preeminent experts; presents the state-of-the-art in enterprise architecture approaches with respect to cloud computing models, frameworks, technologies, and applications; di

  16. Some Terminological and Typological Features of Unrealized Architecture

    Directory of Open Access Journals (Sweden)

    Indrė Gudelytė-Račienė

    2015-12-01

    Full Text Available The article analyzes the topic of unrealized architecture in both linguistic and typological perspective. The author raises hitherto rarely discussed terminological issues, analyzes the most commonly used notions and terms in conjuction with their suitability in architectural discourse. The article suggests the general typological model of unrealized architecture. Furthermore, the paper reveals the change of the concept of some unrealized architectural projects’ types (specifically “utopian” and “visionary” throughout history.

  17. Topical therapies in hyperhidrosis care.

    Science.gov (United States)

    Pariser, David M; Ballard, Angela

    2014-10-01

    Primary focal hyperhidrosis affects 3% of the US population; about the same number as psoriasis. More than half of these patients have primary focal axillary hyperhidrosis: sweating that is beyond what is anticipated or necessary for thermoregulation. Most topical therapies are based on aluminum salts, which work by a chemical reaction that forms plugs in the eccrine sweat ducts. Topical anticholinergics may also be used. Instruction on proper methods and timing of antiperspirants enhances effect and may be effective alone or in combination with other treatments in patients with hyperhidrosis.

  18. Architectural Anthropology

    DEFF Research Database (Denmark)

    Stender, Marie

    and other spaces that architects are preoccupied with. On the other hand, the distinction between architecture and design is not merely one of scale. Design and architecture represent – at least in Denmark – also quite different disciplinary traditions and methods. Where designers develop prototypes......, architects tend to work with models and plans that are not easily understood by lay people. Further, many architects are themselves sceptical towards notions of user-involvement and collaborative design. They fear that the imagination of citizens and users is restricted to what they are already familiar with...

  19. Implicit stage topics

    Directory of Open Access Journals (Sweden)

    Karen Lahousse

    2008-04-01

    Full Text Available Il a souvent été proposé que les éléments spatio-temporels en position initiale de phrase spécifient le cadre de l’événement dénoté par la proposition et ont une interprétation thématique ou topicale. Alors que les topiques spatio-temporels explicites ont souvent été étudiés, Erteschik-Schir (1997, 1999 propose l’idée que les topiques spatio-temporels, ou topiques scéniques (stage topics peuvent aussi être implicites.Dans cet article, nous offrons des arguments en faveur de la notion de topique scénique implicite. Nous montrons qu’un certain nombre de cas d’inversion nominale en français, une configuration syntaxique qui est favorisée par la présence d’un topique scénique explicite, s’expliquent par la présence d’un topique scénique implicite. Le fait que les topiques scéniques implicites interagissent avec la structure syntaxique de la même façon que les topiques scéniques explicites constitue un argument empirique en faveur de leur existence.It has often been proposed that sentence-initial spatio-temporal elements specify the frame in which the whole proposition takes place and are topical (i.e. thematic. Whereas considerable attention has been paid to explicit spatio-temporal topics, Erteschik-Shir (1997, 1999 argues that spatio-temporal topics, or stage topics, can also be implicit.In this article we provide evidence in favour of the notion of implicit stage topic. We show that a certain number of nominal inversion cases in French, a syntactic configuration which is triggered by the presence of an explicit stage topic, are explained by the presence of an implicit stage topic. The fact that implicit stage topics interact with syntactic structure the same way explicit stage topics do constitutes a strong empirical argument in favour of their existence.

  20. Experimental study of impact-cratering damage on brittle cylindrical column model as a fundamental component of space architecture

    Science.gov (United States)

    Fujiwara, Akira; Onose, Naomi; Setoh, Masato; Nakamura, Akiko M.; Hiraoka, Kensuke; Hasegawa, Sunao; Okudaira, Kyoko

    2014-10-01

    The cylindrical column of brittle material processed from soil and rock is a fundamental component of architectures on the surface of solid bodies in the solar system. One of the most hazardous events for the structure is damaging by hypervelocity impacts by meteoroids and debris. In such a background, cylindrical columns made of plaster of Paris and glass-bead-sintered ceramic were impacted by spherical projectiles of nylon, glass, and steel at velocity of about 1-4.5 km/s. Measured crater radii, depth, and excavated mass expressed by a function of the cylinder radius are similar irrespective of the target material, if those parameters are normalized by appropriate parameters of the crater produced on the flat-surface target. The empirical scaling relations of the normalized crater radii and depth are provided. Using them, crater dimensions and excavated mass of crater on cylindrical surface of any radius can be predicted from the existing knowledge of those for flat surface. Recommendation for the minimum diameter of a cylinder so as to resist against a given impact is provided.

  1. Architecture of Kepler's multi-transiting systems. II. New investigations with twice as many candidates

    Energy Technology Data Exchange (ETDEWEB)

    Fabrycky, Daniel C. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Lissauer, Jack J.; Rowe, Jason F.; Barclay, Thomas; Batalha, Natalie; Borucki, William; Jenkins, Jon M.; Li, Jie; Morris, Robert L.; Smith, Jeffrey C. [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Ragozzine, Darin; Geary, John C.; Holman, Matthew J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Steffen, Jason H. [Fermilab Center for Particle Astrophysics, P.O. Box 500, MS 127, Batavia, IL 60510 (United States); Agol, Eric [Department of Astronomy, University of Washington, P.O. Box 351580, Seattle, WA 98195 (United States); Ciardi, David R. [NASA Exoplanet Science Institute/Caltech, 770 South Wilson Avenue, MC 100-2, Pasadena, CA 91125 (United States); Ford, Eric B.; Morehead, Robert C. [Center for Exoplanets and Habitable Worlds, 525 Davey Laboratory, The Pennsylvania State University, University Park, PA 16802 (United States); Gautier, Thomas N.; Shporer, Avi, E-mail: fabrycky@uchicago.edu [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); and others

    2014-08-01

    We report on the orbital architectures of Kepler systems having multiple-planet candidates identified in the analysis of data from the first six quarters of Kepler data and reported by Batalha et al. (2013). These data show 899 transiting planet candidates in 365 multiple-planet systems and provide a powerful means to study the statistical properties of planetary systems. Using a generic mass-radius relationship, we find that only two pairs of planets in these candidate systems (out of 761 pairs total) appear to be on Hill-unstable orbits, indicating ∼96% of the candidate planetary systems are correctly interpreted as true systems. We find that planet pairs show little statistical preference to be near mean-motion resonances. We identify an asymmetry in the distribution of period ratios near first-order resonances (e.g., 2:1, 3:2), with an excess of planet pairs lying wide of resonance and relatively few lying narrow of resonance. Finally, based upon the transit duration ratios of adjacent planets in each system, we find that the interior planet tends to have a smaller transit impact parameter than the exterior planet does. This finding suggests that the mode of the mutual inclinations of planetary orbital planes is in the range 1.°0-2.°2, for the packed systems of small planets probed by these observations.

  2. Sensponsive architecture as a tool to stimulate the senses and alleviate the psychological disorders of an individual.

    Science.gov (United States)

    Liapi, Marianthi; Linaraki, Despoina; Voradaki, Georgia

    2012-08-01

    The paper presents an ongoing research project that aims to help individuals with mild psychological disorders, like depression, to reduce the use of medication and escape a possible addiction to drugs by transforming their immediate or broader living space into a sensponsive environment. It is an innovative, multidisciplinary, non-invasive approach through the domains of architecture, computer science, psychology and endocrinology. Initially, the paper presents the connections between space and human behavior, and specifically, the ways in which the spatial qualities of the surrounding environment affect the human senses and consequently the hormonal changes and the production of the corresponding emotions and actions. As a next step, the paper outlines the creation of sensponsive environments that are programmed to sense human discomfort by monitoring changes in facial expression and body movement and respond to them accordingly by transforming their spatial elements in order to make people feel better. The proposed sensponsive spaces are equipped with biomedical monitoring systems, smart materials and sensor-actuator assemblies with programmed re-actions (haptic, olfactory, chromatic and so on) that help people refine their feeling of the surrounding space, guiding its smooth transition to a comfortable--for the body and the mind-place. The paper concludes with the next step of this research initiative, the sensponsive suit, a personalized wearable assembly enhanced with technology to positively affect the psychological health of the wearer.

  3. A new architecture as transparent electrodes for solar and IR applications based on photonic structures via soft lithography

    Energy Technology Data Exchange (ETDEWEB)

    Kuang, Ping [Iowa State Univ., Ames, IA (United States)

    2011-01-01

    Transparent conducting electrodes with the combination of high optical transmission and good electrical conductivity are essential for solar energy harvesting and electric lighting devices. Currently, indium tin oxide (ITO) is used because ITO offers relatively high transparency (>80%) to visible light and low sheet resistance (Rs = 10 ohms/square (Ω /2)) for electrical conduction. However, ITO is costly due to limited indium reserves, and it is brittle. These disadvantages have motivated the search for other conducting electrodes with similar or better properties. There has been research on a variety of electrode structures involving carbon nanotube networks, graphene films, nanowire and nanopatterned meshes and grids. Due to their novel characteristics in light manipulation and collection, photonic crystal structures show promise for further improvement. Here, we report on a new architecture consisting of nanoscale high aspect ratio metallic photonic structures as transparent electrodes fabricated via a combination of processes. For (Au) and silver (Ag) structures, the visible light transmission can reach as high as 80%, and the sheet resistance of the structure can be as low as 3.2Ω /2. The optical transparency of the high aspect ratio metal structures at visible wavelength range is comparable to that of ITO glass, while their sheet resistance is more than 3 times lower, which indicates a much higher electrical conductivity of the metal structures. Furthermore, the high aspect ratio metal structures have very high infrared (IR) reflection (90%) for the transverse magnetic (TM) mode, which can lead to the development of fabrication of metallic structures as IR filters for heat control applications. Investigations of interdigitated structures based on the high aspect ratio metal electrodes are ongoing to study the feasibility in smart window applications in light transmission modulation.

  4. Orientalist Orientals: re-conceptualizing Ottoman architecture in the late Empire

    Directory of Open Access Journals (Sweden)

    Sibel Bozdogan

    2015-12-01

    Full Text Available Review of Ahmet Ersoy, Architecture and the Late Ottoman Historical Imaginary: Reconfiguring the Architectural Past in a Modernizing Empire: Late Ottoman Empire’s concerted effort to forge a modern imperial identity to better position itself within the emerging world system was accompanied by a proto-nationalist desire for an authentic cultural past. In the field of art and architecture, the result was a new interest and patriotic pride in the Islamic artistic and architectural heritage of the Empire, along with an intense period of creative engagement with European artistic and scholarly discourses. The book offers a meticulously historicized account of what emerged as a major intellectual effort to construct a genealogy for Ottoman architecture, to make it intelligible in terms of Western architectural theory and above all, to recast it as a historically evolving style capable of revival in the modern world. In doing so, it critically engages with recent scholarly debates on modernity, historicism, romanticism, orientalism, nationalism, revivalism, cosmopolitanism, authenticity, eclecticism and hybridity among other topics. Taking issue with both the received “westernization paradigm” and its companion, the notorious “decline thesis” in terms of which the architecture of Ottoman Tanzimat has long been written, it gives us a more complex, more nuanced, more cosmopolitan and more ambivalent picture. As such, it makes a major contribution to Ottoman/ Turkish studies, to the historiography of Islamic architecture and to cross-cultural studies in general.

  5. Recent Advances In Topical Therapy In Dermatology

    Directory of Open Access Journals (Sweden)

    Mohan Thappa Devinder

    2003-01-01

    Full Text Available With changing times various newer topical agents are introduced in the field of dermatology. Tacrolimus and pimecrolimus are immunisuppressants, which are effective topically and are tried in the management of atopic dermatitis as well as other disorders including allergic contact dermatitis, atrophic lichen planus, pyoderma gangrenosum. Imiquimod, an immune response modifier, is presently in use for genital warts but has potentials as anti- tumour agent and in various other dermatological conditions when used topically. Tazarotene is a newer addition to the list of topical reginoids, which is effective in psoriasis and has better effect in combination with calcipotriene, phototherapy and topical costicosteroids. Tazarotene and adapelene are also effective in inflammatory acne. Calcipotriol, a vitamin D analogue has been introduced as a topical agent in the treatment of psoriasis. Steroid components are also developed recently which will be devoid of the side effects but having adequate anti-inflammatory effect. Topical photodynamic therapy has also a wide range of use in dermatology. Newer topical agents including cidofovir, capsaicin, topical sensitizers, topical antifungal agents for onychomycosis are also of use in clinical practice. Other promising developments include skin substitutes and growth factors for wound care.

  6. Topical therapy of molluscum contagiosum as a comparative therapeutic study using 15% phenol in lactic acid, 5% tincture iodine and pricking alone

    Directory of Open Access Journals (Sweden)

    Khalifa E. Sharquie

    2016-07-01

    dermatitis, allergic bronchitis were found in 17 (22.7% patients. After 3 weeks of treatment, the response rates were as follows: Group 1: 23/25 (92% patients cured completely, 2 (8% patients failed to achieve complete clearing, p-value was highly significant 0.05. Scars were not reported in any group. Conclusion: Pricking molluscum contagiosum lesions by orange stick alone is safe, cost effective, highly effective and stimulating mode of therapy. Still topical 15% phenol in lactic acid and 5% tincture iodine are new and effective modes of treatment.

  7. Topics in statistical mechanics

    Energy Technology Data Exchange (ETDEWEB)

    Elser, V.

    1984-05-01

    This thesis deals with four independent topics in statistical mechanics: (1) the dimer problem is solved exactly for a hexagonal lattice with general boundary using a known generating function from the theory of partitions. It is shown that the leading term in the entropy depends on the shape of the boundary; (2) continuum models of percolation and self-avoiding walks are introduced with the property that their series expansions are sums over linear graphs with intrinsic combinatorial weights and explicit dimension dependence; (3) a constrained SOS model is used to describe the edge of a simple cubic crystal. Low and high temperature results are derived as well as the detailed behavior near the crystal facet; (4) the microscopic model of the lambda-transition involving atomic permutation cycles is reexamined. In particular, a new derivation of the two-component field theory model of the critical behavior is presented. Results for a lattice model originally proposed by Kikuchi are extended with a high temperature series expansion and Monte Carlo simulation. 30 references.

  8. Superconcentration and related topics

    CERN Document Server

    Chatterjee, Sourav

    2014-01-01

    A certain curious feature of random objects, introduced by the author as “super concentration,” and two related topics, “chaos” and “multiple valleys,” are highlighted in this book. Although super concentration has established itself as a recognized feature in a number of areas of probability theory in the last twenty years (under a variety of names), the author was the first to discover and explore its connections with chaos and multiple valleys. He achieves a substantial degree of simplification and clarity in the presentation of these findings by using the spectral approach. Understanding the fluctuations of random objects is one of the major goals of probability theory and a whole subfield of probability and analysis, called concentration of measure, is devoted to understanding these fluctuations. This subfield offers a range of tools for computing upper bounds on the orders of fluctuations of very complicated random variables. Usually, concentration of measure is useful when more direct prob...

  9. A Review of Architecture and Climate: An Environmental History of British Architecture, 1600–2000

    Directory of Open Access Journals (Sweden)

    Manolo Guerci

    2013-01-01

    Full Text Available Chronologically arranged in eight essays dealing each with a topical chapter of British architectural history, ranging from the Smythson of Hardwick Hall fame to his twentieth century namesakes, Alison and Peter, the book’s aim is to trace a common line of architecture’s adaptation to the British climate throughout the period examined. The central argument is that factors such as location, light and orientation played a fundamental part in the planning of all the examples selected for discussion.

  10. Architecture for the senses

    DEFF Research Database (Denmark)

    Ryhl, Camilla

    2009-01-01

    findings from the PhD thesis 'A House for the Senses' by the author, a study of architectural requirements in housing design implied by a sensory impairment. The empirical research project is based on qualitative interviews and 1:1 testing in existing housing with participants who were either blind, deaf......Accommodating sensory disabilities in architectural design requires specific design considerations. These are different from the ones included by the existing design concept 'accessibility', which primarily accommodates physical disabilites. Hence a new design concept 'sensory accessbility......' is presented as a parallel and complementary concept to the existing one. Sensory accessiblity accommodates sensory disabilities and describes architectural design requirements needed to ensure access to to the sensory experiences and architectural quality of a given space. The article is based on research...

  11. DSP Architecture Design Essentials

    CERN Document Server

    Marković, Dejan

    2012-01-01

    In DSP Architecture Design Essentials, authors Dejan Marković and Robert W. Brodersen cover a key subject for the successful realization of DSP algorithms for communications, multimedia, and healthcare applications. The book addresses the need for DSP architecture design that maps advanced DSP algorithms to hardware in the most power- and area-efficient way. The key feature of this text is a design methodology based on a high-level design model that leads to hardware implementation with minimum power and area. The methodology includes algorithm-level considerations such as automated word-length reduction and intrinsic data properties that can be leveraged to reduce hardware complexity. From a high-level data-flow graph model, an architecture exploration methodology based on linear programming is used to create an array of architectural solutions tailored to the underlying hardware technology. The book is supplemented with online material: bibliography, design examples, CAD tutorials and custom software.

  12. Minimalism in architecture: Abstract conceptualization of architecture

    Directory of Open Access Journals (Sweden)

    Vasilski Dragana

    2015-01-01

    Full Text Available Minimalism in architecture contains the idea of the minimum as a leading creative tend to be considered and interpreted in working through phenomena of empathy and abstraction. In the Western culture, the root of this idea is found in empathy of Wilhelm Worringer and abstraction of Kasimir Malevich. In his dissertation, 'Abstraction and Empathy' Worringer presented his thesis on the psychology of style through which he explained the two opposing basic forms: abstraction and empathy. His conclusion on empathy as a psychological basis of observation expression is significant due to the verbal congruence with contemporary minimalist expression. His intuition was enhenced furthermore by figure of Malevich. Abstraction, as an expression of inner unfettered inspiration, has played a crucial role in the development of modern art and architecture of the twentieth century. Abstraction, which is one of the basic methods of learning in psychology (separating relevant from irrelevant features, Carl Jung is used to discover ideas. Minimalism in architecture emphasizes the level of abstraction to which the individual functions are reduced. Different types of abstraction are present: in the form as well as function of the basic elements: walls and windows. The case study is an example of Sou Fujimoto who is unequivocal in its commitment to the autonomy of abstract conceptualization of architecture.

  13. Detail in architecture: Between arts & crafts

    Science.gov (United States)

    Dulencin, Juraj

    2016-06-01

    Architectural detail represents an important part of architecture. Not only can it be used as an identifier of a specific building but at the same time enhances the experience of the realized project. Within it lie the signs of a great architect and clues to understanding his or her way of thinking. It is therefore the central topic of a seminar offered to architecture students at the Brno University of Technology. During the course of the semester-long class the students acquaint themselves with atypical architectural details of domestic and international architects by learning to read them, understand them and subsequently draw them by creating architectural blueprints. In other words, by general analysis of a detail the students learn theoretical thinking of its architect who, depending on the nature of the design, had to incorporate a variety of techniques and crafts. Students apply this analytical part to their own architectural detail design. The methodology of the seminar consists of experiential learning by project management and is complemented by a series of lectures discussing a diversity of details as well as materials and technologies required to implement it. The architectural detail design is also part of students' bachelors thesis, therefore, the realistic nature of their blueprints can be verified in the production process of its physical counterpart. Based on their own documentation the students choose the most suitable manufacturing process whether it is supplied by a specific technology or a craftsman. Students actively participate in the production and correct their design proposals in real scale with the actual material. A student, as a future architect, stands somewhere between a client and an artisan, materializes his or her idea and adjusts the manufacturing process so that the final detail fulfills aesthetic consistency and is in harmony with its initial concept. One of the very important aspects of the design is its economic cost, an

  14. The Health Curriculum: 500 Topics.

    Science.gov (United States)

    Byrd, Oliver E.

    2001-01-01

    This 1958 paper divides 500 health topics into 20 categories: health as a social accomplishment/social problem; nutrition; physical fitness; mental health and disease; heredity/eugenics; infection/immunity; chronic and degenerative disease; substance abuse; skin care; vision, hearing, and speech; dental health; safety; physical environment; health…

  15. Bipolarity and Ambivalence in Landscape Architecture

    NARCIS (Netherlands)

    Koh, J.

    2010-01-01

    Our discipline of landscape architecture contains bipolarity, not only in terms of landscape and architecture but also because the idea of landscape is both aesthetic and scientific. Furthermore, within landscape architecture there is a gap between design (as implied by architecture) and planning (i

  16. Architectural Tops

    Science.gov (United States)

    Mahoney, Ellen

    2010-01-01

    The development of the skyscraper is an American story that combines architectural history, economic power, and technological achievement. Each city in the United States can be identified by the profile of its buildings. The design of the tops of skyscrapers was the inspiration for the students in the author's high-school ceramic class to develop…

  17. Architectural Illusion.

    Science.gov (United States)

    Doornek, Richard R.

    1990-01-01

    Presents a lesson plan developed around the work of architectural muralist Richard Haas. Discusses the significance of mural painting and gives key concepts for the lesson. Lists class activities for the elementary and secondary grades. Provides a photograph of the Haas mural on the Fountainbleau Hilton Hotel, 1986. (GG)

  18. Researching Distressing Topics

    Directory of Open Access Journals (Sweden)

    Sharon Jackson

    2013-05-01

    Full Text Available Qualitative researchers who explore sensitive topics may expose themselves to emotional distress. Consequently, researchers are often faced with the challenge of maintaining emotional equilibrium during the research process. However, discussion on the management of difficult emotions has occupied a peripheral place within accounts of research practice. With rare exceptions, the focus of published accounts is concentrated on the analysis of the emotional phenomena that emerge during the collection of primary research data. Hence, there is a comparative absence of a dialogue around the emotional dimensions of working with secondary data sources. This article highlights some of the complex ways in which emotions enter the research process during secondary analysis, and the ways in which we engaged with and managed emotional states such as anger, sadness, and horror. The concepts of emotional labor and emotional reflexivity are used to consider the ways in which we “worked with” and “worked on” emotion. In doing so, we draw on our collective experiences of working on two collaborative projects with ChildLine Scotland in which a secondary analysis was conducted on children’s narratives of distress, worry, abuse, and neglect.

  19. High-level language computer architecture

    CERN Document Server

    Chu, Yaohan

    1975-01-01

    High-Level Language Computer Architecture offers a tutorial on high-level language computer architecture, including von Neumann architecture and syntax-oriented architecture as well as direct and indirect execution architecture. Design concepts of Japanese-language data processing systems are discussed, along with the architecture of stack machines and the SYMBOL computer system. The conceptual design of a direct high-level language processor is also described.Comprised of seven chapters, this book first presents a classification of high-level language computer architecture according to the pr

  20. Internet Naming and Discovery Architecture and Economics

    CERN Document Server

    Khoury, Joud S

    2013-01-01

    Naming is an integral building block within data networks and systems and is becoming ever more important as complex data-centric usage models emerge. Internet Naming and Discovery is timely in developing a unified model for studying the topic of naming and discovery. It details the architectural and economic tools needed for designing naming and discovery schemes within the broader context of internetwork architecture.   Readers will find in this book a historic overview of the Internet and a comprehensive survey of the literature, followed by and an in-depth examination of naming and discovery. Specific topics covered include: ·         formal definitions of name, address, identifier, locator, binding, routing, discovery, mapping, and resolution; ·         a discussion of the properties of names and bindings, along with illustrative case studies; ·         taxonomy that helps in organizing the solution space, and more importantly in identifying new avenues for contributing to the...

  1. Architectural communication: Intra and extra activity of architecture

    Directory of Open Access Journals (Sweden)

    Stamatović-Vučković Slavica

    2013-01-01

    Full Text Available Apart from a brief overview of architectural communication viewed from the standpoint of theory of information and semiotics, this paper contains two forms of dualistically viewed architectural communication. The duality denotation/connotation (”primary” and ”secondary” architectural communication is one of semiotic postulates taken from Umberto Eco who viewed architectural communication as a semiotic phenomenon. In addition, architectural communication can be viewed as an intra and an extra activity of architecture where the overall activity of the edifice performed through its spatial manifestation may be understood as an act of communication. In that respect, the activity may be perceived as the ”behavior of architecture”, which corresponds to Lefebvre’s production of space.

  2. A New Perspective On Architectural Sustainability

    DEFF Research Database (Denmark)

    Hermund, Anders; Klint, Lars; Schipull Kauschen, Jan

    2013-01-01

    The research presented in this paper intends to establish a new perspective on architectural sustainability as an effect of good architectural quality. The intention is to show the importance of an actual architectural mindset in the design phase, and whether the conscious architectural material...... selection based on a balanced cost and aesthetics decision making will prove more sustainable and ensure better maintenance, as a result of architectural appeal, than cheaper standard houses....

  3. Venite & Videte : art and architecture in Brussels as agents of change during the Counter Reformation, c. 1609-1659

    NARCIS (Netherlands)

    Nagelsmit, Eelco Diederik

    2014-01-01

    In the Counter Reformation, art and architecture are often attributed a central role in such a process of persuasion. Recent historical studies, however, have emphasized the intense fear of God that held Early Modern society in its grip, leading to a revision of the traditional view of the Counter R

  4. A new generation of previously unrealizable photonic devices as enabled by a unique electro-optic waveguide architecture

    Science.gov (United States)

    Davis, Scott R.; Rommel, Scott D.; Farca, George; Anderson, Michael H.

    2008-08-01

    A new electro-optic waveguide platform, which provides unprecedented electro-optical phase delays (> 1mm), with very low loss (integrated photonic architecture has applications in a wide array of commercial and defense markets including: remote sensing, micro-LADAR, OCT, laser illumination, phased array radar, optical communications, etc. Performance attributes of several example devices are presented.

  5. Creating comfortable climatic cities : comfort and climate as instruments for healthy interior, architectural & urban (re)design

    NARCIS (Netherlands)

    Doepel, Duzan

    2012-01-01

    After decades of being deemed the idealistic hobby of a niche group of fanatics, Green has finally entered the mainstream of the architectural service industry. However, most architects and urban planners are not yet adequately equipped to translate the challenges of climate change and resource and

  6. Vernacular Architecture as Self-Determination: Venturi, Scott Brown and the Controversy over Philadelphia's Crosstown Expressway, 1967-1973

    Directory of Open Access Journals (Sweden)

    Sebastian Haumann

    2014-07-01

    Full Text Available Between 1967 and 1972 Robert Venturi and Denise Scott Brown worked on two projects simultaneously. One culminated in Learning from Las Vegas, their renowned contribution to architectural theory; the other reflected their political engagement in the so-called Crosstown Controversy. In this project, Venturi and Scott Brown spoke on behalf of a citizens’ initiative opposing a proposed inner-city expressway in the South Street area of Philadelphia. The aesthetic criticism exemplified in their study of Las Vegas found parallels in the political critique embodied by the alternative scheme they developed for the Philadelphia citizen group. This scheme proposed to revalorise the vernacular architecture of the existing neighbourhood, against the wholesale demolition implied in the official plans for the Crosstown Expressway.This article investigates the connections between aesthetic ideals and social concern in the work of Venturi and Scott Brown. Embedding the discussion on architectural theory in the concrete context of urban history reveals important links between intellectual discourse and political action. Venturi and Scott Brown’s repeated reference to social aspects of architecture can only be understood, so this article demonstrates, if we analyse the concrete engagements in which they developed their projects. The South Street project offers a concrete occasion wherein the architects were forced to adopt a political position.

  7. Usage-Oriented Topic Maps Building Approach

    Science.gov (United States)

    Ellouze, Nebrasse; Lammari, Nadira; Métais, Elisabeth; Ben Ahmed, Mohamed

    In this paper, we present a collaborative and incremental construction approach of multilingual Topic Maps based on enrichment and merging techniques. In recent years, several Topic Map building approaches have been proposed endowed with different characteristics. Generally, they are dedicated to particular data types like text, semi-structured data, relational data, etc. We note also that most of these approaches take as input monolingual documents to build the Topic Map. The problem is that the large majority of resources available today are written in various languages, and these resources could be relevant even to non-native speakers. Thus, our work is driven towards a collaborative and incremental method for Topic Map construction from textual documents available in different languages. To enrich the Topic Map, we take as input a domain thesaurus and we propose also to explore the Topic Map usage which means available potential questions related to the source documents.

  8. Effects of co-inoculation with arbuscular mycorrhizal fungi and rhizobia on soybean growth as related to root architecture and availability of N and P.

    Science.gov (United States)

    Wang, Xiurong; Pan, Qiang; Chen, Fengxian; Yan, Xiaolong; Liao, Hong

    2011-04-01

    Soybean plants can form tripartite symbiotic associations with rhizobia and arbuscular mycorrhizal (AM) fungi, but little is known about effects of co-inoculation with rhizobia and AM fungi on plant growth, or their relationships to root architecture as well as nitrogen (N) and phosphorus (P) availability. In the present study, two soybean genotypes contrasting in root architecture were grown in a field experiment to evaluate relationships among soybean root architecture, AMF colonization, and nodulation under natural conditions. Additionally, a soil pot experiment in greenhouse was conducted to investigate the effects of co-inoculation with rhizobia and AM fungi on soybean growth, and uptake of N and P. Our results indicated that there was a complementary relationship between root architecture and AMF colonization in the field. The deep root soybean genotype had greater AMF colonization at low P, but better nodulation with high P supply than the shallow root genotype. A synergistic relationship dependent on N and P status exists between rhizobia and AM fungi on soybean growth. Co-inoculation with rhizobia and AM fungi significantly increased soybean growth under low P and/or low N conditions as indicated by increased shoot dry weight, along with plant N and P content. There were no significant effects of inoculation under adequate N and P conditions. Furthermore, the effects of co-inoculation were related to root architecture. The deep root genotype, HN112, benefited more from co-inoculation than the shallow root genotype, HN89. Our results elucidate new insights into the relationship between rhizobia, AM fungi, and plant growth under limitation of multiple nutrients, and thereby provides a theoretical basis for application of co-inoculation in field-grown soybean.

  9. Computational methods for predicting the response of critical as-built infrastructure to dynamic loads (architectural surety)

    Energy Technology Data Exchange (ETDEWEB)

    Preece, D.S.; Weatherby, J.R.; Attaway, S.W.; Swegle, J.W.; Matalucci, R.V.

    1998-06-01

    Coupled blast-structural computational simulations using supercomputer capabilities will significantly advance the understanding of how complex structures respond under dynamic loads caused by explosives and earthquakes, an understanding with application to the surety of both federal and nonfederal buildings. Simulation of the effects of explosives on structures is a challenge because the explosive response can best be simulated using Eulerian computational techniques and structural behavior is best modeled using Lagrangian methods. Due to the different methodologies of the two computational techniques and code architecture requirements, they are usually implemented in different computer programs. Explosive and structure modeling in two different codes make it difficult or next to impossible to do coupled explosive/structure interaction simulations. Sandia National Laboratories has developed two techniques for solving this problem. The first is called Smoothed Particle Hydrodynamics (SPH), a relatively new gridless method comparable to Eulerian, that is especially suited for treating liquids and gases such as those produced by an explosive. The SPH capability has been fully implemented into the transient dynamics finite element (Lagrangian) codes PRONTO-2D and -3D. A PRONTO-3D/SPH simulation of the effect of a blast on a protective-wall barrier is presented in this paper. The second technique employed at Sandia National Laboratories uses a relatively new code called ALEGRA which is an ALE (Arbitrary Lagrangian-Eulerian) wave code with specific emphasis on large deformation and shock propagation. ALEGRA is capable of solving many shock-wave physics problems but it is especially suited for modeling problems involving the interaction of decoupled explosives with structures.

  10. Endoscopic Resection and Topical 5-Fluorouracil as an Alternative Treatment to Craniofacial Resection for the Management of Primary Intestinal-Type Sinonasal Adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Simon Mackie

    2010-01-01

    Conclusion. Trans-nasal endoscopic resection and topical 5-Fluorouracil could potentially offer an acceptable alternative treatment to the standard of cranio-facial resection. This should be investigated in trials with a longer followup period than this paper in order to directly compare the two treatment modalities.

  11. Severe photosensitivity reaction induced by topical diclofenac

    OpenAIRE

    Akat, Pramod B.

    2013-01-01

    Albeit uncommon, photosensitivity reaction induced by diclofenac can be an unfortunate adverse reaction complicating its use as a topical analgesic. We here present a case of a patient who suffered such a reaction as a result of exposure to diclofenac, employed as a topical analgesic for low backache. The lesions healed with conservative management without extensive scarring or other complications.

  12. Severe photosensitivity reaction induced by topical diclofenac

    Directory of Open Access Journals (Sweden)

    Pramod B Akat

    2013-01-01

    Full Text Available Albeit uncommon, photosensitivity reaction induced by diclofenac can be an unfortunate adverse reaction complicating its use as a topical analgesic. We here present a case of a patient who suffered such a reaction as a result of exposure to diclofenac, employed as a topical analgesic for low backache. The lesions healed with conservative management without extensive scarring or other complications.

  13. Tracking topic birth and death in LDA.

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Andrew T.; Robinson, David Gerald

    2011-09-01

    Most topic modeling algorithms that address the evolution of documents over time use the same number of topics at all times. This obscures the common occurrence in the data where new subjects arise and old ones diminish or disappear entirely. We propose an algorithm to model the birth and death of topics within an LDA-like framework. The user selects an initial number of topics, after which new topics are created and retired without further supervision. Our approach also accommodates many of the acceleration and parallelization schemes developed in recent years for standard LDA. In recent years, topic modeling algorithms such as latent semantic analysis (LSA)[17], latent Dirichlet allocation (LDA)[10] and their descendants have offered a powerful way to explore and interrogate corpora far too large for any human to grasp without assistance. Using such algorithms we are able to search for similar documents, model and track the volume of topics over time, search for correlated topics or model them with a hierarchy. Most of these algorithms are intended for use with static corpora where the number of documents and the size of the vocabulary are known in advance. Moreover, almost all current topic modeling algorithms fix the number of topics as one of the input parameters and keep it fixed across the entire corpus. While this is appropriate for static corpora, it becomes a serious handicap when analyzing time-varying data sets where topics come and go as a matter of course. This is doubly true for online algorithms that may not have the option of revising earlier results in light of new data. To be sure, these algorithms will account for changing data one way or another, but without the ability to adapt to structural changes such as entirely new topics they may do so in counterintuitive ways.

  14. New Energy Architecture. Myanmar

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-06-15

    A global transition towards a new energy architecture is under way, driven by countries' need to respond to the changing dynamics of economic growth, environmental sustainability and energy security. The World Economic Forum, in collaboration with Accenture, has created the New Energy Architecture Initiative to address and accelerate this transition. The Initiative supports the development of national strategies and policy frameworks as countries seek to achieve the combined goals of energy security and access, sustainability, and economic growth and development. The World Economic Forum has formed a partnership with the Ministry of Energy of Myanmar to help apply the Initiative's approach to this developing and resource-rich nation. The Asian Development Bank and the World Economic Forum's Project Adviser, Accenture, have collaborated with the Forum on this consultation process, and have been supported by relevant government, industry and civil society stakeholders. The consultation process aims to understand the nation's current energy architecture challenges and provide an overview of a path to a New Energy Architecture through a series of insights. These insights could form the basis for a long-term multistakeholder roadmap to build Myanmar's energy sector in a way that is secure and sustainable, and promotes economic growth as the country makes its democratic transition. While not all recommendations can be implemented in the near term, they do provide options for creating a prioritized roadmap for Myanmar's energy transition. This report is the culmination of a nine-month multistakeholder process investigating Myanmar's energy architecture. Over the course of many visits to the country, the team has conducted numerous interviews, multistakeholder workshops, and learning and data-gathering exercises to ensure a comprehensive range of information and views. The team has also engaged with a variety of stakeholders to better

  15. MUF architecture /art London

    DEFF Research Database (Denmark)

    Svenningsen Kajita, Heidi

    2009-01-01

    Om MUF architecture samt interview med Liza Fior og Katherine Clarke, partnere i muf architecture/art......Om MUF architecture samt interview med Liza Fior og Katherine Clarke, partnere i muf architecture/art...

  16. Characters and Topical Diversity

    DEFF Research Database (Denmark)

    Eriksson, Rune

    2014-01-01

    The purpose of this article is to contribute to our understanding of the difference between the bestseller and the non-bestseller in nonfiction. It is noticed that many bestsellers in nonfiction belongs to the sub-genre of creative nonfiction, but also that the topics in this kind of literature i...

  17. Contrastive topics decomposed

    Directory of Open Access Journals (Sweden)

    Michael Wagner

    2012-12-01

    Full Text Available The analysis of contrastive topics introduced in Büring 1997b and further developed in Büring 2003 relies on distinguishing two types of constituents that introduce alternatives: the sentence focus, which is marked by a FOC feature, and the contrastive topic, which is marked by a CT feature. A non-compositional rule of interpretation that refers to these features is used to derive a topic semantic value, a nested set of sets of propositions. This paper presents evidence for a correlation between the restrictive syntax of nested focus operators and the syntax of contrastive topics, a correlation which is unexpected under this analysis. A compositional analysis is proposed that only makes use of the flatter focus semantic values introduced by focus operators. The analysis aims at integrating insights from the original analysis while at the same time capturing the observed syntactic restrictions. http://dx.doi.org/10.3765/sp.5.8 BibTeX info

  18. Topics in Nonlinear Dynamics

    DEFF Research Database (Denmark)

    Mosekilde, Erik

    Through a significant number of detailed and realistic examples this book illustrates how the insights gained over the past couple of decades in the fields of nonlinear dynamics and chaos theory can be applied in practice. Aomng the topics considered are microbiological reaction systems, ecological...

  19. Topics for Mathematics Clubs.

    Science.gov (United States)

    Dalton, LeRoy C., Ed.; Snyder, Henry D., Ed.

    The ten chapters in this booklet cover topics not ordinarily discussed in the classroom: Fibonacci sequences, projective geometry, groups, infinity and transfinite numbers, Pascal's Triangle, topology, experiments with natural numbers, non-Euclidean geometries, Boolean algebras, and the imaginary and the infinite in geometry. Each chapter is…

  20. The University of Arizona College of Architecture and Landscape Architecture,Tucson,Arizona%亚和桑那大学的建筑和景观设计

    Institute of Scientific and Technical Information of China (English)

    布拉得利·韦勒

    2008-01-01

    @@ A textbook illustration of modern, sustainable, site specific and symbolically iconographic architecture stands as an addition to the renowned University of Arizona College of Architecture and Landscape Architecture.

  1. BUILDING SUSTAINABLE ARCHITECTURAL DESIGN: A RENOVATION PROJECT

    OpenAIRE

    Hakan ÜNALAN,; TOKMAN, Leyla Y.

    2011-01-01

    Today, the conservation of energy and respect for the natural environment appears to be the most important phenomena in all areas. In this regard, "sustainability" concept emerged and the architectural platform "Sustainable Architecture" is composed of a research subject to the new and permanent. Architecture underlying the "design" as including also the new concept of "sustainable architectural design" has revealed that field. Sustainable architecture "building in-house", "building envelop...

  2. BUILDING SUSTAINABLE ARCHITECTURAL DESIGN: A RENOVATION PROJECT

    OpenAIRE

    ÜNALAN, Hakan; TOKMAN, Leyla Yekdane

    2011-01-01

    Today, the conservation of energy and respect for the natural environment appears to be the most important phenomena in all areas. In this regard, "sustainability" concept emerged and the architectural platform "Sustainable Architecture" is composed of a research subject to the new and permanent. Architecture underlying the "design" as including also the new concept of "sustainable architectural design" has revealed that field.    Sustainable architecture "building in-house", "...

  3. Parallel Architectures and Bioinspired Algorithms

    CERN Document Server

    Pérez, José; Lanchares, Juan

    2012-01-01

    This monograph presents examples of best practices when combining bioinspired algorithms with parallel architectures. The book includes recent work by leading researchers in the field and offers a map with the main paths already explored and new ways towards the future. Parallel Architectures and Bioinspired Algorithms will be of value to both specialists in Bioinspired Algorithms, Parallel and Distributed Computing, as well as computer science students trying to understand the present and the future of Parallel Architectures and Bioinspired Algorithms.

  4. Kosmos = architecture

    Directory of Open Access Journals (Sweden)

    Tine Kurent

    1985-12-01

    Full Text Available The old Greek word "kosmos" means not only "cosmos", but also "the beautiful order", "the way of building", "building", "scenography", "mankind", and, in the time of the New Testament, also "pagans". The word "arhitekton", meaning first the "master of theatrical scenography", acquired the meaning of "builder", when the words "kosmos" and ~kosmetes" became pejorative. The fear that architecture was not considered one of the arts before Renaissance, since none of the Muses supervised the art of building, results from the misunderstanding of the word "kosmos". Urania was the Goddes of the activity implied in the verb "kosmein", meaning "to put in the beautiful order" - everything, from the universe to the man-made space, i. e. the architecture.

  5. Design and Evaluation of Topical Diclofenac Sodium Gel Using Hot Melt Extrusion Technology as a Continuous Manufacturing Process with Kolliphor® P407.

    Science.gov (United States)

    Pawar, Jaywant; Narkhede, Rajkiran; Amin, Purnima; Tawde, Vaishali

    2017-01-20

    The aim of the present context was to develop and evaluate a Kolliphor® P407-based transdermal gel formulation of diclofenac sodium by hot melt extrusion (HME) technology; central composite design was used to optimize the formulation process. In this study, we have explored first time ever HME as an industrially feasible and continuous manufacturing technology for the manufacturing of gel formulation using Kolliphor® P407 and Kollisolv® PEG400 as a gel base. Diclofenac sodium was used as a model drug. The HME parameters such as feeding rate, screw speed, and barrel temperature were crucial for the semisolid product development, and were optimized after preliminary trials. For the processing of the gel formulation by HME, a modified screw design was used to obtain a uniform product. The obtained product was evaluated for physicochemical characterization such as differential scanning calorimetry (DSC), X-ray diffraction (XRD), pH measurement, rheology, surface tension, and texture profile analysis. Moreover, it was analyzed for general appearance, spreadibility, surface morphology, and drug content. The optimized gel formulation showed homogeneity and transparent film when applied on a glass slide under microscope, pH was 7.02 and uniform drug content of 100.04 ± 2.74 (SD = 3). The DSC and XRD analysis of the HME gel formulation showed complete melting of crystalline API into an amorphous form. The Kolliphor® P407 and Kollisolv® PEG400 formed excellent gel formulation using HME with consistent viscoelastic properties of the product. An improved drug release was found for the HME gel, which showed a 100% drug release than that of a marketed product which showed only 88% of drug release at the end of 12 h. The Flux value of the HME gel was 106 than that of a marketed formulation, which showed only about 60 value, inferring a significant difference (P < 0.05) at the end of 1 h. This study demonstrates a novel application of the hot melt extrusion

  6. Modelling the effect of wheat canopy architecture as affected by sowing density on Septoria tritici epidemics using a coupled epidemic–virtual plant model

    Science.gov (United States)

    Baccar, Rim; Fournier, Christian; Dornbusch, Tino; Andrieu, Bruno; Gouache, David; Robert, Corinne

    2011-01-01

    Background and Aims The relationship between Septoria tritici, a splash-dispersed disease, and its host is complex because of the interactions between the dynamic plant architecture and the vertical progress of the disease. The aim of this study was to test the capacity of a coupled virtual wheat–Septoria tritici epidemic model (Septo3D) to simulate disease progress on the different leaf layers for contrasted sowing density treatments. Methods A field experiment was performed with winter wheat ‘Soissons’ grown at three contrasted densities. Plant architecture was characterized to parameterize the wheat model, and disease dynamic was monitored to compare with simulations. Three simulation scenarios, differing in the degree of detail with which plant variability of development was represented, were defined. Key Results Despite architectural differences between density treatments, few differences were found in disease progress; only the lower-density treatment resulted in a slightly higher rate of lesion development. Model predictions were consistent with field measurements but did not reproduce the higher rate of lesion progress in the low density. The canopy reconstruction scenario in which inter-plant variability was taken into account yielded the best agreement between measured and simulated epidemics. Simulations performed with the canopy represented by a population of the same average plant deviated strongly from the observations. Conclusions It was possible to compare the predicted and measured epidemics on detailed variables, supporting the hypothesis that the approach is able to provide new insights into the processes and plant traits that contribute to the epidemics. On the other hand, the complex and dynamic responses to sowing density made it difficult to test the model precisely and to disentangle the various aspects involved. This could be overcome by comparing more contrasted and/or simpler canopy architectures such as those resulting from quasi

  7. The pharmacology of topical analgesics.

    Science.gov (United States)

    Barkin, Robert L

    2013-07-01

    systemic circulation, topically applied analgesics are associated with application-site reactions in patients, such as dryness, erythema, burning, and discoloration. Furthermore, some adverse events that have been observed in patients may be suggestive of some degree of systemic exposure. This article reviews the mechanisms of action, pharmacokinetics, and tolerability of topical treatments for the management of patient pain.

  8. The treatment of rosacea with topical ivermectin.

    Science.gov (United States)

    Ali, S T; Alinia, H; Feldman, S R

    2015-04-01

    The treatment of rosacea is challenging because several pathophysiologic processes may be involved, including neurovascular dysregulation and alterations in innate immune status. Demodex mites may play a role in the latter mechanism. Topical ivermectin is a new therapeutic modality which demonstrates antiparasitic and anti-inflammatory properties. This article reviews published evidence related to the efficacy and safety of topical ivermectin. PubMed was utilized to search for key words "topical ivermectin", "ivermectin cream" and "rosacea". Three clinical trials were found that studied topical ivermectin as a treatment option for rosacea. Ivermectin was effective, safe and well tolerated.

  9. Algorithms, architectures and information systems security

    CERN Document Server

    Sur-Kolay, Susmita; Nandy, Subhas C; Bagchi, Aditya

    2008-01-01

    This volume contains articles written by leading researchers in the fields of algorithms, architectures, and information systems security. The first five chapters address several challenging geometric problems and related algorithms. These topics have major applications in pattern recognition, image analysis, digital geometry, surface reconstruction, computer vision and in robotics. The next five chapters focus on various optimization issues in VLSI design and test architectures, and in wireless networks. The last six chapters comprise scholarly articles on information systems security coverin

  10. Fibrin network architectures in pure platelet-rich plasma as characterized by fiber radius and correlated with clotting time.

    Science.gov (United States)

    Perez, Amanda G M; Rodrigues, Ana A; Luzo, Angela C M; Lana, José F S D; Belangero, William D; Santana, Maria H A

    2014-08-01

    Fibrin networks are obtained through activation of platelet-rich plasma (PRP) for use in tissue regeneration. The importance of fibrin networks relies on mediation of release of growth factors, proliferation of tissue cells and rheological properties of the fibrin gels. Activation of PRP usually involves the decomposition of fibrinogen by agonists, in a wide range of concentrations. Therefore fibrin networks with a large structural diversity are formed, making comparative evaluations difficult. In order to standardize the fibrin networks, we used the statistical techniques central composite rotatable design and response-surface analysis, to correlate the radius of the fibers with the ratios between the agonists (autologous serum/calcium chloride) and agonist/PRP. From an individual and interactive analysis of the variables, architectures characterized by thick, medium and thin fibers were delineated on the response-surface. Furthermore, the architectures were correlated with coagulation time. This approach is valuable for standardizing the PRP preparation for clinical applications.

  11. Probabilistic analysis and related topics

    CERN Document Server

    Bharucha-Reid, A T

    1979-01-01

    Probabilistic Analysis and Related Topics, Volume 2 focuses on the integrability, continuity, and differentiability of random functions, as well as functional analysis, measure theory, operator theory, and numerical analysis.The selection first offers information on the optimal control of stochastic systems and Gleason measures. Discussions focus on convergence of Gleason measures, random Gleason measures, orthogonally scattered Gleason measures, existence of optimal controls without feedback, random necessary conditions, and Gleason measures in tensor products. The text then elaborates on an

  12. Architectural Theory: A Construction Site

    Directory of Open Access Journals (Sweden)

    Ákos Moravánszky

    2014-07-01

    Full Text Available Around 1968 we saw the birth of a new architectural theory as the conjunction of architectural history and politically engaged architectural criticism. Not the aesthetics of architecture, but architecture itself in its structural relations with social life became the focus of attention. As a result of this development, it is no longer possible to study architectural history without a critical reflection on the method of the study itself and without a grade of interdisciplinarity. Traditional methods of historiography and iconography have been replaced by new approaches configured by psychoanalysis, deconstruction, cultural studies etc. Appropriation has become the proof of criticality both in architectural theory and in design; however, the understanding of the concepts and methods of other disciplines is basically metaphorical. The problem for a school of architecture lies not in the ‘criticality’ of the kind of architectural theory we described as emerging from the spirit of 1968, but in its discursive nature. The disciplinary specificity of architecture resists a discursive approach, and architectural students frequently question the usefulness of theory which undermines the notion of the ‘project’, without articulating a constructive proposal. Projectivity does not seem to provide an answer; its claim of performativity lacks the program to regain its organising power over contributions from other specialised disciplines and practices. Theory should focus on the terms of our discipline, which are so close to our ‘core beliefs’ regarding architecture that we usually take their meaning for granted. It would be wrong to see this focus of theory as a withdrawal into the realm of language. Indeed, after a period of theory alienating architects and the general public, it could now create a rhetoric to influence our understanding of our environment, which is itself organised on the level of language. The requirement that theory should

  13. Contemporary earthen architecture in Mexico

    OpenAIRE

    Aguilar Prieto, Berenice

    2009-01-01

    The purpose of this study is to put forward an appraisal of current remarkable works of earthen architecture in Mexico, where raw earth architecture, particularly in adobe, has been built since ancient times, but has nevertheless, been substituted by industrial materials that bring poor living conditions for the inhabitants both in urban as in rural areas. Recently, rather than vernacular architecture built by its users, it is within architectonic design that a kind of revival ...

  14. Church Attendance as a Predictor of Number of Sexual Health Topics Discussed Among High-Risk HIV-Negative Black Women.

    Science.gov (United States)

    Williams, Terrinieka T; Pichon, Latrice C; Davey-Rothwell, Melissa; Latkin, Carl A

    2016-02-01

    Research suggests that sexual health communication is associated with safer sex practices. In this study, we examined the relationship between church attendance and sexual health topics discussed with both friends and sexual partners among a sample of urban Black women. Participants were 434 HIV-negative Black women who were at high risk for contracting HIV through heterosexual sex. They were recruited from Baltimore, Maryland using a network-based sampling approach. Data were collected through face-to-face interviews and Audio-Computer-Assisted Self-Interviews. Fifty-four percent of the participants attended church once a month or more (regular attendees). Multivariate logistic regression analyses revealed that regular church attendance among high-risk HIV-negative Black women was a significant predictor of the number of sexual health topics discussed with both friends (AOR = 1.85, p = .003) and sexual partners (AOR = 1.68, p = .014). Future efforts to reduce HIV incidence among high-risk Black women may benefit from partnerships with churches that equip faith leaders and congregants with the tools to discuss sexual health topics with both their sexual partners and friends.

  15. Architectural Prototyping in Industrial Practice

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Hansen, Klaus Marius

    2008-01-01

    Architectural prototyping is the process of using executable code to investigate stakeholders’ software architecture concerns with respect to a system under development. Previous work has established this as a useful and cost-effective way of exploration and learning of the design space of a system......, in addressing issues regarding quality attributes, in addressing architectural risks, and in addressing the problem of knowledge transfer and conformance. Little work has been reported so far on the actual industrial use of architectural prototyping. In this paper, we report from an ethnographical study...... prototypes include end-user or business related functionality rather than purely architectural functionality. Based on these observations we provide recommendations for effective industrial architectural prototyping....

  16. Novel Topic Authorship Attribution

    Science.gov (United States)

    2011-03-01

    cross-validation, genre shift, vector projection, singular value decomposition, principal component analysis Unclassified Unclassified Unclassified...by eight students. Each student wrote a total of 24 documents in three different genres about three different topics. They found that compensating for...Baayen, H. Halteren, A. Neijt, and F. Tweedie, “Outside the cave of shadows: Using syntactic annotation to enhance authorship attribution,” Literary

  17. Enterprise architecture evaluation using architecture framework and UML stereotypes

    Directory of Open Access Journals (Sweden)

    Narges Shahi

    2014-08-01

    Full Text Available There is an increasing need for enterprise architecture in numerous organizations with complicated systems with various processes. Support for information technology, organizational units whose elements maintain complex relationships increases. Enterprise architecture is so effective that its non-use in organizations is regarded as their institutional inability in efficient information technology management. The enterprise architecture process generally consists of three phases including strategic programing of information technology, enterprise architecture programing and enterprise architecture implementation. Each phase must be implemented sequentially and one single flaw in each phase may result in a flaw in the whole architecture and, consequently, in extra costs and time. If a model is mapped for the issue and then it is evaluated before enterprise architecture implementation in the second phase, the possible flaws in implementation process are prevented. In this study, the processes of enterprise architecture are illustrated through UML diagrams, and the architecture is evaluated in programming phase through transforming the UML diagrams to Petri nets. The results indicate that the high costs of the implementation phase will be reduced.

  18. Architectural dreaming

    Institute of Scientific and Technical Information of China (English)

    Mark Godfrey

    2004-01-01

    <正> For the first 800 years of its existence, Beijing retained essentially the same character: a walled palace city at its centre, organised on a strict north-south axis and contained within a sea of courtyard houses along lanes too narrow forcars. Today Beijing’s basic unit of architectural scale has become the skyscraper, erected a dozen at a time and facing massive highways. Ancient buildings are so small and unloved by comparison that they threaten to disappear from view. Fuelled by an economic boom, and propelled by banks flushed with mortgage cash, Beijing has embarked on the largest building campaign the world has ever seen.

  19. Prioritizing dermatoses: rationally selecting guideline topics

    NARCIS (Netherlands)

    Borgonjen, R.J.; Everdingen, J.J. van; Kerkhof, P.C.M. van de; Spuls, P.I.

    2015-01-01

    BACKGROUND: Clinical practice guideline (CPG) development starts with selecting appropriate topics, as resources to develop a guideline are limited. However, a standardized method for topic selection is commonly missing and the way different criteria are used to prioritize is not clear. OBJECTIVES:

  20. Psoriasis: improving adherence to topical therapy.

    NARCIS (Netherlands)

    Feldman, S.R.; Horn, E.J.; Balkrishnan, R.; Basra, M.K.; Finlay, A.Y.; McCoy, D.; Menter, A.; Kerkhof, P.C.M. van de

    2008-01-01

    Topical therapy has an important role in psoriasis treatment. It is efficacious and has a favorable safety profile as demonstrated in clinical trials. However, poor treatment outcomes from topical therapy regimens likely result from poor adherence and ineffective use of the medication. The Internati

  1. Towards an Architectural Anthropology

    DEFF Research Database (Denmark)

    Stender, Marie

    2016-01-01

    their overlaps and collaboration. However, there are also challenging differences to take into account regarding disciplinary traditions of, for example, communication, temporality, and normativity. This article explores the potentials and challenges of architectural anthropology as a distinct sub......Architecture and anthropology have always had overlapping interests regarding issues such as spatial organisation, forms of human dwellings, and the interplay between social life and physical surroundings. Recent developments in both disciplines make it even more relevant to explore and evolve......-discipline and outlines its possible theoretical, methodological, and applied contributions. It is proposed that the ambition to understand people in a different way than they understand themselves is key in both disciplines, and that architectural anthropology is consequently not only relevant in studies of vernacular...

  2. Towards an Architectural Anthropology

    DEFF Research Database (Denmark)

    Stender, Marie

    2016-01-01

    Architecture and anthropology have always had overlapping interests regarding issues such as spatial organisation, forms of human dwellings, and the interplay between social life and physical surroundings. Recent developments in both disciplines make it even more relevant to explore and evolve...... their overlaps and collaboration. However, there are also challenging differences to take into account regarding disciplinary traditions of, for example, communication, temporality, and normativity. This article explores the potentials and challenges of architectural anthropology as a distinct sub......-discipline and outlines its possible theoretical, methodological, and applied contributions. It is proposed that the ambition to understand people in a different way than they understand themselves is key in both disciplines, and that architectural anthropology is consequently not only relevant in studies of vernacular...

  3. IT Service Management Architectures

    DEFF Research Database (Denmark)

    Tambo, Torben; Filtenborg, Jacob

    2017-01-01

    IT service providers tend to view their services as quasi-embedded in the client organisations infrastructure. Therefore, IT service providers lack a full picture of being an organisation with its own enterprise archicture. By systematically developing an enterprise architecture using the unifica......IT service providers tend to view their services as quasi-embedded in the client organisations infrastructure. Therefore, IT service providers lack a full picture of being an organisation with its own enterprise archicture. By systematically developing an enterprise architecture using...

  4. An Indoor Monitoring System for Ambient Assisted Living Based on Internet of Things Architecture

    OpenAIRE

    Gonçalo Marques; Rui Pitarma

    2016-01-01

    The study of systems and architectures for ambient assisted living (AAL) is undoubtedly a topic of great relevance given the aging of the world population. The AAL technologies are designed to meet the needs of the aging population in order to maintain their independence as long as possible. As people typically spend more than 90% of their time in indoor environments, indoor air quality (iAQ) is perceived as an imperative variable to be controlled for the inhabitants’ wellbeing and comfort. A...

  5. Hot topics in functional neuroradiology.

    Science.gov (United States)

    Faro, S H; Mohamed, F B; Helpern, J A; Jensen, J H; Thulborn, K R; Atkinson, I C; Sair, H I; Mikulis, D J

    2013-12-01

    Functional neuroradiology represents a relatively new and ever-growing subspecialty in the field of neuroradiology. Neuroradiology has evolved beyond anatomy and basic tissue signal characteristics and strives to understand the underlying physiologic processes of central nervous system disease. The American Society of Functional Neuroradiology sponsors a yearly educational and scientific meeting, and the educational committee was asked to suggest a few cutting-edge functional neuroradiology techniques (hot topics). The following is a review of several of these topics and includes "Diffusion Tensor Imaging of the Pediatric Spinal Cord"; "Diffusional Kurtosis Imaging"; "From Standardization to Quantification: Beyond Biomarkers toward Bioscales as Neuro MR Imaging Surrogates of Clinical End Points"; Resting-State Functional MR Imaging"; and "Current Use of Cerebrovascular Reserve Imaging."

  6. Systems of Vegetal Façade and Green Roofs used as a Sustainable Option in Architecture

    OpenAIRE

    Chanampa, Mariana; Vidal Rivas, Pilar; Alonso Ojembarrena, Javier; Olivieri, Francesca

    2010-01-01

    Green architecture contributes not only in reducing the building’s thermal loads but also in reducing the effects of the urban heat island in densely built-up areas in a hardly natural environment. The current green systems are built in situ/on site and are very expensive, hence the need to create industrialized prevegetated systems which improve the buildings’ energy savings and reduce the times of construction works. The present paper describes three green systems for façades (gabion façade...

  7. Principles of landscape architecture

    NARCIS (Netherlands)

    Nijhuis, S.

    2013-01-01

    The Department of Urbanism at the Faculty of Architecture and Built Environment, TU Delft considers urbanism as a planning and design oriented activity towards urban and rural landscapes. It aims to enhance, restore or create landscapes from a perspective of sustainable development, so as to guide,

  8. Correlated Topic Model for Web Services Ranking

    Directory of Open Access Journals (Sweden)

    Mustapha AZNAG

    2013-07-01

    Full Text Available With the increasing number of published Web services providing similar functionalities, it’s very tedious for a service consumer to make decision to select the appropriate one according to her/his needs. In this paper, we explore several probabilistic topic models: Probabilistic Latent Semantic Analysis (PLSA, Latent Dirichlet Allocation (LDA and Correlated Topic Model (CTM to extract latent factors from web service descriptions. In our approach, topic models are used as efficient dimension reduction techniques, which are able to capture semantic relationships between word-topic and topic-service interpreted in terms of probability distributions. To address the limitation of keywords-based queries, we represent web service description as a vector space and we introduce a new approach for discovering and ranking web services using latent factors. In our experiment, we evaluated our Service Discovery and Ranking approach by calculating the precision (P@n and normalized discounted cumulative gain (NDCGn.

  9. Architecture of Environmental Engineering

    DEFF Research Database (Denmark)

    Wenzel, Henrik; Alting, Leo

    2006-01-01

    An architecture of Environmental Engineering has been developed comprising the various disciplines and tools involved. It identifies industry as the major actor and target group, and it builds on the concept of Eco-efficiency. To improve Eco-efficiency, there is a limited number of intervention......-efficiency is the aim of Environmental Engineering, the discipline of synthesis – design and creation of solutions – will form a core pillar of the architecture. Other disciplines of Environmental Engineering exist forming the necessary background and frame for the synthesis. Environmental Engineering, thus, in essence...... comprise the disciplines of: management, system description & inventory, analysis & assessment, prioritisation, synthesis, and communication, each existing at all levels of intervention. The developed architecture of Environmental Engineering, thus, consists of thirty individual disciplines, within each...

  10. Architecture of Environmental Engineering

    DEFF Research Database (Denmark)

    Wenzel, Henrik; Alting, Leo

    2004-01-01

    An architecture of Environmental Engineering has been developed comprising the various disciplines and tools involved. It identifies industry as the major actor and target group, and it builds on the concept of Eco-efficiency. To improve Eco-efficiency, there is a limited number of intervention...... of Eco-efficiency is the aim of Environmental Engineering, the discipline of synthesis – design and creation of solutions – will form a core pillar of the architecture. Other disciplines of Environmental Engineering exist forming the necessary background and frame for the synthesis. Environmental...... Engineering, thus, in essence comprise the disciplines of: management, system description & inventory, analysis & assessment, prioritisation, synthesis, and communication, each existing at all levels of intervention. The developed architecture of Environmental Engineering, thus, consists of thirty individual...

  11. Architectures of prototypes and architectural prototyping

    DEFF Research Database (Denmark)

    Hansen, Klaus Marius; Christensen, Michael; Sandvad, Elmer;

    1998-01-01

    together as a team, but developed a prototype that more than fulfilled the expectations of the shipping company. The prototype should: - complete the first major phase within 10 weeks, - be highly vertical illustrating future work practice, - continuously live up to new requirements from prototyping...... sessions with users, - evolve over a long period of time to contain more functionality - allow for 6-7 developers working intensively in parallel. Explicit focus on the software architecture and letting the architecture evolve with the prototype played a major role in resolving these conflicting......This paper reports from experience obtained through development of a prototype of a global customer service system in a project involving a large shipping company and a university research group. The research group had no previous knowledge of the complex business of shipping and had never worked...

  12. Architecture Knowledge Management: Challenges, Approaches, and Tools

    Energy Technology Data Exchange (ETDEWEB)

    Babar, Muhammad A.; Gorton, Ian

    2007-08-01

    Capturing the technical knowledge, contextual information, and rationale surrounding the design decisions underpinning system architectures can greatly improve the software development process. If not managed, this critical knowledge is implicitly embedded in the architecture, becoming tacit knowledge which erodes as personnel on the project change. Moreover, the unavailability of architecture knowledge precludes organizations from growing their architectural capabilities. In this tutorial, we highlight the benefits and challenges in managing software architecture knowledge. We discuss various approaches to characterize architecture knowledge based on the requirements of a particular domain. We describe various concepts and approaches to manage the architecture knowledge from both management and technical perspectives. We also demonstrate the utility of captured knowledge to support software architecture activities with a case study covering the use of architecture knowledge management techniques and tools in an industrial project.

  13. Architectural Engineering to Super-Light Structures

    DEFF Research Database (Denmark)

    Castberg, Niels Andreas

    with architectural engineering as a starting point. The thesis is based on a two stringed hypothesis: Architectural engineering gives rise to better architecture and Super-Light Structures support and enables a static, challenging architecture. The aim of the thesis is to clarify architectural engineering's impact...... on the work process between architects and engineers in the design development. Using architectural engineering, Super-Light Structures are examined in an architectural context, and it is explained how digital tools can support architectural engineering and design of Super-Light Structures. The experiences...... to be subjects of examination for this thesis. The research results show that architectural engineering has a significant impact on a design process. The projects illustrate that simple explanations, underpinned by visualisations of the challenges between shape versus structure, often creates a shared...

  14. Minimizing the Risk of Architectural Decay by using Architecture-Centric Evolution Process

    CERN Document Server

    Farid, Humaira; Iqbal, M Aqeel

    2011-01-01

    Software systems endure many noteworthy changes throughout their life-cycle in order to follow the evolution of the problem domains. Generally, the software system architecture cannot follow the rapid evolution of a problem domain which results in the discrepancies between the implemented and designed architecture. Software architecture illustrates a system's structure and global properties and consequently determines not only how the system should be constructed but also leads its evolution. Architecture plays an important role to ensure that a system satisfies its business and mission goals during implementation and evolution. However, the capabilities of the designed architecture may possibly be lost when the implementation does not conform to the designed architecture. Such a loss of consistency causes the risk of architectural decay. The architectural decay can be avoided if architectural changes are made as early as possible. The paper presents the Process Model for Architecture-Centric Evolution which ...

  15. Large scale topic modeling made practical

    DEFF Research Database (Denmark)

    Wahlgreen, Bjarne Ørum; Hansen, Lars Kai

    2011-01-01

    Topic models are of broad interest. They can be used for query expansion and result structuring in information retrieval and as an important component in services such as recommender systems and user adaptive advertising. In large scale applications both the size of the database (number of docume......Topic models are of broad interest. They can be used for query expansion and result structuring in information retrieval and as an important component in services such as recommender systems and user adaptive advertising. In large scale applications both the size of the database (number...... topics at par with a much larger case specific vocabulary....

  16. Topical diclofenac does not affect the antiplatelet properties of aspirin as compared to the intermediate effects of oral diclofenac: A prospective, randomized, complete crossover study.

    Science.gov (United States)

    Rowcliffe, M; Nezami, B; Westphal, E S; Rainka, M; Janda, M; Bates, V; Gengo, F

    2016-04-01

    Nonsteroidal anti-inflammatory drugs (NSAIDs) adversely interact with aspirin, diminishing its antiplatelet effect and potentially placing patients at an increased risk for recurrent thrombotic events. This crossover study aimed to determine whether the topical NSAID diclofenac epolamine 1.3% patch or oral diclofenac 50 mg interfered with the antiplatelet effects of aspirin 325 mg. Twelve healthy men and women aged 18-50 were included. Participants were randomized into 5 treatment arms: aspirin, diclofenac potassium 50 mg, diclofenac patch, diclofenac potassium plus ASA 325 mg, and diclofenac patch plus aspirin. Platelet responsiveness was determined using whole-blood impedance aggregation (WBA) to collagen 1 μg/mL and arachidonic acid (AA) 0.5 mM and was sampled every 2 hours. No significant difference in platelet function was observed following the diclofenac patch and aspirin vs aspirin alone. Oral diclofenac produced a mixed effect with significant reduction in platelet inhibition at hour 2 and hour 8 following aspirin administration. Topical diclofenac does not significantly interfere with the antiplatelet effects of aspirin and may be a safer alternative to the oral formulation.

  17. Architecture Design & Network Application of Cloud Computing

    Directory of Open Access Journals (Sweden)

    Mehzabul Hoque Nahid

    2015-08-01

    Full Text Available “Cloud” computing a comparatively term, stands on decades of research & analysis in virtualization, analytical distributed computing, utility computing, and more recently computer networking, web technology and software services. Cloud computing represents a shift away from computing as a product that is purchased, to computing as a service that is delivered to consumers over the internet from large-scale data centers – or “clouds”. Whilst cloud computing is obtaining growing popularity in the IT industry, academic appeared to be lagging behind the developments in this field. It also implies a service oriented designed architecture, reduced information technology overhead for the end-user, good flexibility, reduced total cost of private ownership, on-demand services and many other things. This paper discusses the concept of “cloud” computing, some of the issues it tries to address, related research topics, and a “cloud” implementation available today

  18. Terra Harvest software architecture

    Science.gov (United States)

    Humeniuk, Dave; Klawon, Kevin

    2012-06-01

    Under the Terra Harvest Program, the DIA has the objective of developing a universal Controller for the Unattended Ground Sensor (UGS) community. The mission is to define, implement, and thoroughly document an open architecture that universally supports UGS missions, integrating disparate systems, peripherals, etc. The Controller's inherent interoperability with numerous systems enables the integration of both legacy and future UGS System (UGSS) components, while the design's open architecture supports rapid third-party development to ensure operational readiness. The successful accomplishment of these objectives by the program's Phase 3b contractors is demonstrated via integration of the companies' respective plug-'n'-play contributions that include controllers, various peripherals, such as sensors, cameras, etc., and their associated software drivers. In order to independently validate the Terra Harvest architecture, L-3 Nova Engineering, along with its partner, the University of Dayton Research Institute, is developing the Terra Harvest Open Source Environment (THOSE), a Java Virtual Machine (JVM) running on an embedded Linux Operating System. The Use Cases on which the software is developed support the full range of UGS operational scenarios such as remote sensor triggering, image capture, and data exfiltration. The Team is additionally developing an ARM microprocessor-based evaluation platform that is both energy-efficient and operationally flexible. The paper describes the overall THOSE architecture, as well as the design decisions for some of the key software components. Development process for THOSE is discussed as well.

  19. Corporate Architecture and Limited Liability

    NARCIS (Netherlands)

    Couwenberg, Oscar

    2007-01-01

    Abstract This paper studies the effect of limited liability on corporate architecture. Corporate architecture refers to the use of governance instruments within the firm to control the behavior of employees. Four general instruments are defined that form the basis of the firm as a governance arrange

  20. THE SCENE OF ARCHITECTURAL SPACE IN THE CONTEX PRESSIVE BEING OF ARCHITECTURAL SPACE

    Directory of Open Access Journals (Sweden)

    Elena E. BIRYUKOVA

    2015-01-01

    Full Text Available The aesthetic aspects of the existence of architectural space is closely related to its scene. The scene of architectural objects and all the architectural space allow enables the existence and active external expression of its non-use component, abstract spiritual meanings, ideas and images. The purpose of this study is the aesthetic and philosophical analysis of the shape of architectural space. The research problem is the search for the relationship between the scene of the architectural space and its existence as the outer presentation of spiritual meanings. Under the scene of architectural space we mean to its expressive exterior shell that is available to the perception of the senses. Architectural space is a certain visibility. This space by which can act spiritual aspects of the human content of architecture. The architectural scene is not only the look of the architectural object or element of architectural space, but and architectural appearance (face of the people. The architectural scene is built in accordance with the needs of the inner world of man and contains the image of the person in the material form. It is also the external scene of the architectural environment for human been and appearance of the individual life. Therefore, the scene of architecture is concrete space. National, social, cultural identity finds expression through the scene of its architectural space. 

  1. Architectural Drawing - an Animate Field

    DEFF Research Database (Denmark)

    Hougaard, Anna Katrine

    2015-01-01

    important affordance of architectural drawing as a ¬hybrid between the openness of hand-sketching and the rule-based-ness of diagramming, an affordance which might be useful in the migrational zone of current architectural drawing where traditional hand drawing techniques and computer drawing techniques......Architectural drawing is changing because architects today draw with computers. Due to this change digital diagrams employed by computational architectural practices are often emphasized as powerful structures of control and organisation in the design process. But there are also diagrams, which do...... ways of directing behaviour of artefacts and living things without controlling this behaviour completely. I analyse a musical composition by John Cage as an example of a sketch diagram, and then hypothesize that orthogonal, architectural drawing can work in similar ways. Thereby I hope to point out...

  2. Ontology-driven health information systems architectures.

    Science.gov (United States)

    Blobel, Bernd; Oemig, Frank

    2009-01-01

    Following an architecture vision such as the Generic Component Model (GCM) architecture framework, health information systems for supporting personalized care have to be based on a component-oriented architecture. Representing concepts and their interrelations, the GCM perspectives system architecture, domains, and development process can be described by the domains' ontologies. The paper introduces ontology principles, ontology references to the GCM as well as some practical aspects of ontology-driven approaches to semantically interoperable and sustainable health information systems.

  3. Architecture Analysis of an FPGA-Based Hopfield Neural Network

    Directory of Open Access Journals (Sweden)

    Miguel Angelo de Abreu de Sousa

    2014-01-01

    Full Text Available Interconnections between electronic circuits and neural computation have been a strongly researched topic in the machine learning field in order to approach several practical requirements, including decreasing training and operation times in high performance applications and reducing cost, size, and energy consumption for autonomous or embedded developments. Field programmable gate array (FPGA hardware shows some inherent features typically associated with neural networks, such as, parallel processing, modular executions, and dynamic adaptation, and works on different types of FPGA-based neural networks were presented in recent years. This paper aims to address different aspects of architectural characteristics analysis on a Hopfield Neural Network implemented in FPGA, such as maximum operating frequency and chip-area occupancy according to the network capacity. Also, the FPGA implementation methodology, which does not employ multipliers in the architecture developed for the Hopfield neural model, is presented, in detail.

  4. IT Service Management Architectures

    DEFF Research Database (Denmark)

    Tambo, Torben; Filtenborg, Jacob

    2017-01-01

    IT service providers tend to view their services as quasi-embedded in the client organisations infrastructure. Therefore, IT service providers lack a full picture of being an organisation with its own enterprise archicture. By systematically developing an enterprise architecture using...

  5. Interactive Architecture #1

    NARCIS (Netherlands)

    Oosterhuis, K.; Xia, X.

    2007-01-01

    The iA bookzine series will consist of twelve issues, bi-annually published over a period of six years under the supervision of Prof. ir. Kas Oosterhuis, director of the Hperbody at the Delft University of Technology. Interactive Architecture - from here on abbreviated as iA - is NOT simply archite

  6. Future Network Architectures

    DEFF Research Database (Denmark)

    Wessing, Henrik; Bozorgebrahimi, Kurosh; Belter, Bartosz;

    2015-01-01

    This study identifies key requirements for NRENs towards future network architectures that become apparent as users become more mobile and have increased expectations in terms of availability of data. In addition, cost saving requirements call for federated use of, in particular, the optical spec...

  7. Enterprise Architecture Evaluation

    DEFF Research Database (Denmark)

    Andersen, Peter; Carugati, Andrea

    2014-01-01

    By being holistically preoccupied with coherency among organizational elements such as organizational strategy, business needs and the IT functions role in supporting the business, enterprise architecture (EA) has grown to become a core competitive advantage. Though EA is a maturing research area...

  8. Hot topics for leadership development.

    Science.gov (United States)

    Bleich, Michael R

    2015-02-01

    Three areas stand out from a health systems perspective that should be on the development agenda for all leaders. These topics include population health, predictive analytics, and supply chain management. Together, these topics address access, quality, and cost management.

  9. Soap-stone in architecture of North European cities. A nomination as a candidate for a Global Heritage Stones Resource

    Science.gov (United States)

    Bulakh, Andrey

    2016-04-01

    Soap stone represents soft Proterozoic rock type from the deposit Nunnalahti situated on the western shore of the big Lake Pielinen in Eastern Finland. It consists of talc (40 - 50 %), magnesite MgCO3 (40 - 50 %), chlorite (5 - 8 %), dolomite, calcite, etc. The colour of the stone is very spectacular and varies from yellow and brownish-yellow to grey, greenish grey. The soft stone is a highly workable material for a sculptor's chisel. It was one of the most popular ornamental rocks used architecture of the Modern style in St Petersburg, Helsinki, Turku, Tampere and other North European cities lately in the XIX-th centuries. Examples are given and discussed. References: Bulakh, A.G., Abakumova, N.B., and Romanovsky, J.V. St Petersburg: a History in Stone. 2010. Print House of St Petersburg State University. 173 p. (In English).

  10. Decoding the architectural theory

    Institute of Scientific and Technical Information of China (English)

    Gu Mengchao

    2008-01-01

    Starting from the illustration of the definition and concept of the architectural theory, the author established his unique understanding about the framework of the architectural theory and the innovation of the architectural theory underlined by Chinese characteristics.

  11. Topics in orbit equivalence

    CERN Document Server

    Kechris, Alexander S

    2004-01-01

    This volume provides a self-contained introduction to some topics in orbit equivalence theory, a branch of ergodic theory. The first two chapters focus on hyperfiniteness and amenability. Included here are proofs of Dye's theorem that probability measure-preserving, ergodic actions of the integers are orbit equivalent and of the theorem of Connes-Feldman-Weiss identifying amenability and hyperfiniteness for non-singular equivalence relations. The presentation here is often influenced by descriptive set theory, and Borel and generic analogs of various results are discussed. The final chapter is a detailed account of Gaboriau's recent results on the theory of costs for equivalence relations and groups and its applications to proving rigidity theorems for actions of free groups.

  12. Drawing Architecture Theory on the City

    NARCIS (Netherlands)

    Altürk, E.

    2009-01-01

    This study is about architectural drawings. I especially address how drawings operate in architecture theory, and stress a particular role that they play in facilitating critique and speculation as theoretical activities. In this sense, I dwell on the capacity of architectural drawing not only as re

  13. Architecture Studio Archive: A Case Study in the Comprehensive Digital Capture and Repository of Student Design Work as an Aid to Teaching, Research, and Accreditation

    Science.gov (United States)

    Anderson, Ross; Arndell, Michael; Christensen, Sten

    2009-01-01

    The "Architecture Studio Archive" pilot sought to form a comprehensive digital archive of the diverse student work conducted in the first year of the Bachelor of Design in Architecture Degree at the University of Sydney. The design studio is the primary vehicle for teaching architectural design. It is a locus for creative activity, with students…

  14. Architecture Studio Archive: A Case Study in the Comprehensive Digital Capture and Repository of Student Design Work as an Aid to Teaching, Research, and Accreditation

    Science.gov (United States)

    Anderson, Ross; Arndell, Michael; Christensen, Sten

    2009-01-01

    The "Architecture Studio Archive" pilot sought to form a comprehensive digital archive of the diverse student work conducted in the first year of the Bachelor of Design in Architecture Degree at the University of Sydney. The design studio is the primary vehicle for teaching architectural design. It is a locus for creative activity, with…

  15. Natural energy and vernacular architecture

    Energy Technology Data Exchange (ETDEWEB)

    Fathy, H.

    1986-01-01

    This volume presents insights into the indigenous architectural forms in hot arid climates. The author presents his extensive research on climate control, particularly in the Middle East, to demonstrate the advantages of many locally available building materials and traditional building methods. He suggests improved uses of natural energy that can bridge the gap between traditional achievements and modern needs. He argues that various architectural forms in these climates have evolved intuitively from scientifically valid concepts. Such forms combine comfort and beauty, social and physical functionality. He discusses that in substituting modern materials, architects sometimes have ignored the environmental context of traditional architecture. As a result, individuals may find themselves physically and psychologically uncomfortable in modern structures. His approach, informed by a sensitive humanism, demonstrates the ways in which traditional architectural forms can be of use in solving problems facing contemporary architecture, in particular the critical housing situation in the Third World.

  16. Architecture in the Experience City

    DEFF Research Database (Denmark)

    Kiib, Hans

    2009-01-01

    . The article identifies new rationales related to this development, and it argues that ‘cultural planning' has increasingly shifted its focus from a cultural institutional approach to a more market-oriented strategy that combines art and business in a close relationship. The role of architecture has changed......This article focuses on the combination of programs and the architecture of cultural projects that have emerged within the last few years. These projects are characterized in the article as ‘hybrid cultural projects', because they intend to combine experience with entertainment, play and learning...... narratives related to historical buildings and architectural heritage; another group tries to embed new performative technologies in expressive architectural representation. The article provides a theoretical framework for the analysis of the political rationales of these projects and for the architectural...

  17. Modeling Architectural Patterns Using Architectural Primitives

    NARCIS (Netherlands)

    Zdun, Uwe; Avgeriou, Paris

    2005-01-01

    Architectural patterns are a key point in architectural documentation. Regrettably, there is poor support for modeling architectural patterns, because the pattern elements are not directly matched by elements in modeling languages, and, at the same time, patterns support an inherent variability that

  18. Lightweight enterprise architectures

    CERN Document Server

    Theuerkorn, Fenix

    2004-01-01

    STATE OF ARCHITECTUREArchitectural ChaosRelation of Technology and Architecture The Many Faces of Architecture The Scope of Enterprise Architecture The Need for Enterprise ArchitectureThe History of Architecture The Current Environment Standardization Barriers The Need for Lightweight Architecture in the EnterpriseThe Cost of TechnologyThe Benefits of Enterprise Architecture The Domains of Architecture The Gap between Business and ITWhere Does LEA Fit? LEA's FrameworkFrameworks, Methodologies, and Approaches The Framework of LEATypes of Methodologies Types of ApproachesActual System Environmen

  19. Potential theory—selected topics

    CERN Document Server

    Aikawwa, Hiroaki

    1996-01-01

    The first part of these lecture notes is an introduction to potential theory to prepare the reader for later parts, which can be used as the basis for a series of advanced lectures/seminars on potential theory/harmonic analysis. Topics covered in the book include minimal thinness, quasiadditivity of capacity, applications of singular integrals to potential theory, L(p)-capacity theory, fine limits of the Nagel-Stein boundary limit theorem and integrability of superharmonic functions. The notes are written for an audience familiar with the theory of integration, distributions and basic functional analysis.

  20. Digital Social Network Mining for Topic Discovery

    Science.gov (United States)

    Moradianzadeh, Pooya; Mohi, Maryam; Sadighi Moshkenani, Mohsen

    Networked computers are expanding more and more around the world, and digital social networks becoming of great importance for many people's work and leisure. This paper mainly focused on discovering the topic of exchanging information in digital social network. In brief, our method is to use a hierarchical dictionary of related topics and words that mapped to a graph. Then, with comparing the extracted keywords from the context of social network with graph nodes, probability of relation between context and desired topics will be computed. This model can be used in many applications such as advertising, viral marketing and high-risk group detection.