WorldWideScience

Sample records for arabidopsis case studies

  1. Sustainable funding for biocuration: The Arabidopsis Information Resource (TAIR) as a case study of a subscription-based funding model.

    Science.gov (United States)

    Reiser, Leonore; Berardini, Tanya Z; Li, Donghui; Muller, Robert; Strait, Emily M; Li, Qian; Mezheritsky, Yarik; Vetushko, Andrey; Huala, Eva

    2016-01-01

    Databases and data repositories provide essential functions for the research community by integrating, curating, archiving and otherwise packaging data to facilitate discovery and reuse. Despite their importance, funding for maintenance of these resources is increasingly hard to obtain. Fueled by a desire to find long term, sustainable solutions to database funding, staff from the Arabidopsis Information Resource (TAIR), founded the nonprofit organization, Phoenix Bioinformatics, using TAIR as a test case for user-based funding. Subscription-based funding has been proposed as an alternative to grant funding but its application has been very limited within the nonprofit sector. Our testing of this model indicates that it is a viable option, at least for some databases, and that it is possible to strike a balance that maximizes access while still incentivizing subscriptions. One year after transitioning to subscription support, TAIR is self-sustaining and Phoenix is poised to expand and support additional resources that wish to incorporate user-based funding strategies. Database URL: www.arabidopsis.org. PMID:26989150

  2. The potential of text mining in data integration and network biology for plant research: a case study on Arabidopsis

    OpenAIRE

    Van Landeghem, Sofie; De Bodt, Stefanie; Drebert, Zuzanna; Inzé, Dirk; Van de Peer, Yves

    2013-01-01

    Despite the availability of various data repositories for plant research, a wealth of information currently remains hidden within the biomolecular literature. Text mining provides the necessary means to retrieve these data through automated processing of texts. However, only recently has advanced text mining methodology been implemented with sufficient computational power to process texts at a large scale. In this study, we assess the potential of large-scale text mining for plant biology res...

  3. Complementarity of medium-throughput in situ RNA hybridization and tissue-specific transcriptomics: case study of Arabidopsis seed development kinetics.

    Science.gov (United States)

    Francoz, Edith; Ranocha, Philippe; Pernot, Clémentine; Ru, Aurélie Le; Pacquit, Valérie; Dunand, Christophe; Burlat, Vincent

    2016-01-01

    The rationale of this study is to compare and integrate two heterologous datasets intended to unravel the spatiotemporal specificities of gene expression in a rapidly growing and complex organ. We implemented medium-throughput RNA in situ hybridization (ISH) for 39 genes mainly corresponding to cell wall proteins for which we have particular interest, selected (i) on their sequence identity (24 class III peroxidase multigenic family members and 15 additional genes used as positive controls) and (ii) on their expression levels in a publicly available Arabidopsis thaliana seed tissue-specific transcriptomics study. The specificity of the hybridization signals was carefully studied, and ISH results obtained for the 39 selected genes were systematically compared with tissue-specific transcriptomics for 5 seed developmental stages. Integration of results illustrates the complementarity of both datasets. The tissue-specific transcriptomics provides high-throughput possibilities whereas ISH provides high spatial resolution. Moreover, depending on the tissues and the developmental stages considered, one or the other technique appears more sensitive than the other. For each tissue/developmental stage, we finally determined tissue-specific transcriptomic threshold values compatible with the spatiotemporally-specific detection limits of ISH for lists of hundreds to tens-of-thousands of genes. PMID:27095274

  4. [Arabidopsis thaliana accessions - a tool for biochemical and phylogentical studies].

    Science.gov (United States)

    Szymańska, Renata; Gabruk, Michał; Kruk, Jerzy

    2015-01-01

    Arabidopsis thaliana since a few decades is used as a model for biological and plant genetic research. Natural variation of this species is related to its geographical range which covers different climate zones and habitats. The ability to occupy such a wide area by Arabidopsis is possible due to its stress tolerance and adaptability. Arabidopsis accessions exhibit phenotypic and genotypic variation, which is a result of adaptation to local environmental conditions. During development, plants are subjected to various stress factors. Plants show a spectrum of reactions, processes and phenomena that determine their survival in these adverse conditions. The response of plants to stress involves signal detection and transmission. These reactions are different and depend on the stressor, its intensity, plant species and life strategy. It is assumed that the populations of the same species from different geographical regions acclimated to the stress conditions develop a set of alleles, which allow them to grow and reproduce. Therefore, the study of natural variation in response to abiotic stress among Arabidopsis thaliana accessions allows to find key genes or alleles, and thus the mechanisms by which plants cope with adverse physical and chemical conditions. This paper presents an overview of recent findings, tools and research directions used in the study of natural variation in Arabidopsis thaliana accessions. Additionally, we explain why accessions can be used in the phylogenetic analyses and to study demography and migration of Arabidopsis thaliana. PMID:26281359

  5. Phosphoproteomic studies in Arabidopsis and tobacco male gametophytes

    OpenAIRE

    Fíla, J. (Jan); Čapková, V. (Věra); Honys, D. (David)

    2014-01-01

    Mature pollen represents an extremely resistant quiescent structure surrounded by a tough cell wall. After its hydration on stigma papillary cells, pollen tube growth starts rapidly. Massive metabolic changes are likely to be accompanied by changes in protein phosphorylation. Protein phosphorylation belongs among the most rapid post-translational modifications. To date, only Arabidopsis thaliana and tobacco (Nicotiana tabacum) mature pollen have been subjected to phosphoproteomic studies in o...

  6. Case Studies

    International Nuclear Information System (INIS)

    Proven options available to Sri Lanka for large scale electricity generation in the future are coal-fired thermal, oil-fired thermal and Nuclear. Four case studies for groups participated are indicated. Case study for group 1 is comparison of the three options by taking into consideration the capital and recurrent expenditure involved. Environmental effects of the three options are also given. Case study for group 2 is economic comparison of three renewable energy based power generation system. Case study for group 3 is based on energy conservation, efficiency, improvement and demand management. Assuming that a continuous saving of 20 MW of demand from 1996 onwards is effective two projects are suggested to achieve this result. Case study for group 4 is a feasibility study for hydro power development of the Kukule Ganga (river) in Sri Lanka. Participants are required to evaluate one of the three optional development concepts which are technically feasible

  7. A proteomics study of auxin effects in Arabidopsis thaliana

    Institute of Scientific and Technical Information of China (English)

    Meiqing Xing; Hongwei Xue

    2012-01-01

    Many phytohormones regulate plant growth and development through modulating protein degradation.In this study,a proteome study based on multidimensional non-gel shotgun approach was performed to analyze the auxin-induced protein degradation via ubiquitinproteasome pathway of Arabidopsis thaliana,with the emphasis to study the overall protein changes after auxin treatment (1 nM or 1 μM indole-3-acetic acid for 6,12,or 24 h).More than a thousand proteins were detected by using label-free shotgun method,and 386 increased proteins and 370 decreased ones were identified after indole-3-acetic acid treatment.By using the auxin receptor-deficient mutant,tir1-1,as control,comparative analysis revealed that 69 and 79 proteins were significantly decreased and increased,respectively.Detailed analysis showed that among the altered proteins,some were previously reported to be associated with auxin regulation and others are potentially involved in mediating the auxin effects on specific cellular and physiological processes by regulating photosynthesis,chloroplast development,cytoskeleton,and intracellular signaling.Our results demonstrated that label-free shotgun proteomics is a powerful tool for large-scale protein identification and the analysis of the proteomic profiling of auxin-regulated biological processes will provide informative clues of underlying mechanisms of auxin effects.These results will help to expand the understanding of how auxin regulates plant growth and development via protein degradation.

  8. Molecular screening tools to study Arabidopsis transcription factors

    Directory of Open Access Journals (Sweden)

    Nora eWehner

    2011-11-01

    Full Text Available In the model plant Arabidopsis thaliana, more than 2000 genes are estimated to encode transcription factors (TFs, which clearly emphasizes the importance of transcriptional control. Although genomic approaches have generated large TF Open Reading Frame (ORF collections, only a limited number of these genes is functionally characterized, yet. This review evaluates strategies and methods to identify TF functions. In particular, we focus on two recently developed TF screening platforms, which make use of publi-cally available GATEWAY® compatible ORF collections. (1 The Arabidopsis thaliana TF ORF over-Expression (AtTORF-Ex library provides pooled collections of transgenic lines over-expressing HA-tagged TF genes, which are suited for screening approaches to define TF functions in stress defense and development. (2 A high-throughput microtiter plate based Protoplast Trans Activation (PTA system has been established to screen for TFs which are regulating a given promoter:Luciferase construct in planta.

  9. Phosphoproteomic studies in Arabidopsis and tobacco male gametophytes

    Czech Academy of Sciences Publication Activity Database

    Fíla, Jan; Čapková, Věra; Honys, David

    2014-01-01

    Roč. 42, č. 2 (2014), s. 383-387. ISSN 0300-5127 R&D Projects: GA ČR(CZ) GAP501/11/1462; GA ČR(CZ) GAP305/12/2611; GA ČR GA13-06943S; GA MŠk(CZ) LD13049 Institutional support: RVO:61389030 Keywords : Arabidopsis thaliana * male gametophyte * mature pollen Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.194, year: 2014

  10. Quantitative proteomics approaches to study leaf senescence in Arabidopsis thaliana

    OpenAIRE

    Hebeler, Romano

    2007-01-01

    Im Vergleich zu Arabidopsis thaliana Wildtyppflanzen zeigen onset of leaf death (old) Mutanten vorgezogene Blattseneszenz. Ziel der Arbeit war es, mittels relativ quantitativer Proteomics molekulare Prozesse der frühen Blattseneszenz zu analysieren. Zwei-dimensionale "difference gel electrophoresis" (DIGE) wurde eingesetzt, um Unterschiede in den Proteinkonzentrationen von A. thaliana mit normaler und veränderter Blattseneszenz zu bestimmen. Die regulierten Proteine wurden durc...

  11. Study of natural variation for Zn deficiency tolerance in Arabidopsis thaliana

    NARCIS (Netherlands)

    Campos, A.C.A.L.

    2015-01-01

    English summary Zinc is an important structural component and co-factor of proteins in all living organisms. The model plant species for genetic and molecular studies, Arabidopsis thaliana, expresses more than 2,000 proteins with one or more Zn binding domains. Low Zn availability i

  12. Case Study: Writing a Journal Case Study

    Science.gov (United States)

    Prud'homme-Genereux, Annie

    2016-01-01

    This column provides original articles on innovations in case study teaching, assessment of the method, as well as case studies with teaching notes. This month's issue describes incorporating a journal article into the classroom by first converting it into a case study.

  13. Case Study Teaching

    Science.gov (United States)

    Herreid, Clyde Freeman

    2011-01-01

    This chapter describes the history of case study teaching, types of cases, and experimental data supporting their effectiveness. It also describes a model for comparing the efficacy of the various case study methods. (Contains 1 figure.)

  14. Arabidopsis seedling flood-inoculation technique: a rapid and reliable assay for studying plant-bacterial interactions

    Directory of Open Access Journals (Sweden)

    Uppalapati Srinivasa R

    2011-10-01

    Full Text Available Abstract Background The Arabidopsis thaliana-Pseudomonas syringae model pathosystem is one of the most widely used systems to understand the mechanisms of microbial pathogenesis and plant innate immunity. Several inoculation methods have been used to study plant-pathogen interactions in this model system. However, none of the methods reported to date are similar to those occurring in nature and amicable to large-scale mutant screens. Results In this study, we developed a rapid and reliable seedling flood-inoculation method based on young Arabidopsis seedlings grown on MS medium. This method has several advantages over conventional soil-grown plant inoculation assays, including a shorter growth and incubation period, ease of inoculation and handling, uniform infection and disease development, requires less growth chamber space and is suitable for high-throughput screens. In this study we demonstrated the efficacy of the Arabidopsis seedling assay to study 1 the virulence factors of P. syringae pv. tomato DC3000, including type III protein secretion system (TTSS and phytotoxin coronatine (COR; 2 the effector-triggered immunity; and 3 Arabidopsis mutants affected in salicylic acid (SA- and pathogen-associated molecular pattern (PAMPs-mediated pathways. Furthermore, we applied this technique to study nonhost resistance (NHR responses in Arabidopsis using nonhost pathogens, such as P. syringae pv. tabaci, pv. glycinea and pv. tomato T1, and confirmed the functional role of FLAGELLIN-SENSING 2 (FLS2 in NHR. Conclusions The Arabidopsis seedling flood-inoculation assay provides a rapid, efficient and economical method for studying Arabidopsis-Pseudomonas interactions with minimal growth chamber space and time. This assay could also provide an excellent system for investigating the virulence mechanisms of P. syringae. Using this method, we demonstrated that FLS2 plays a critical role in conferring NHR against nonhost pathovars of P. syringae, but not to

  15. Project management case studies

    CERN Document Server

    Kerzner, Harold R

    2013-01-01

    A new edition of the most popular book of project management case studies, expanded to include more than 100 cases plus a ""super case"" on the Iridium Project Case studies are an important part of project management education and training. This Fourth Edition of Harold Kerzner''s Project Management Case Studies features a number of new cases covering value measurement in project management. Also included is the well-received ""super case,"" which covers all aspects of project management and may be used as a capstone for a course. This new edition:Contains 100-plus case studies drawn from re

  16. Sugars as hydroxyl radical scavengers: proof-of-concept by studying the fate of sucralose in Arabidopsis.

    Science.gov (United States)

    Matros, Andrea; Peshev, Darin; Peukert, Manuela; Mock, Hans-Peter; Van den Ende, Wim

    2015-06-01

    Substantial formation of reactive oxygen species (ROS) is inevitable in aerobic life forms. Due to their extremely high reactivity and short lifetime, hydroxyl radicals are a special case, because cells have not developed enzymes to detoxify these most dangerous ROS. Thus, scavenging of hydroxyl radicals may only occur by accumulation of higher levels of simple organic compounds. Previous studies have demonstrated that plant-derived sugars show hydroxyl radical scavenging capabilities during Fenton reactions with Fe(2+) and hydrogen peroxide in vitro, leading to formation of less detrimental sugar radicals that may be subject of regeneration to non-radical carbohydrates in vivo. Here, we provide further evidence for the occurrence of such radical reactions with sugars in planta, by following the fate of sucralose, an artificial analog of sucrose, in Arabidopsis tissues. The expected sucralose recombination and degradation products were detected in both normal and stressed plant tissues. Oxidation products of endogenous sugars were also assessed in planta for Arabidopsis and barley, and were shown to increase in abundance relative to the non-oxidized precursor during oxidative stress conditions. We concluded that such non-enzymatic reactions with hydroxyl radicals form an integral part of plant antioxidant mechanisms contributing to cellular ROS homeostasis, and may be more important than generally assumed. This is discussed in relation to the recently proposed roles for Fe(2+) and hydrogen peroxide in processes leading to the origin of metabolism and the origin of life. PMID:25891826

  17. A comparative study of salt tolerance parameters in 11 wild relatives of Arabidopsis thaliana

    KAUST Repository

    Orsini, Francesco

    2010-07-01

    Salinity is an abiotic stress that limits both yield and the expansion of agricultural crops to new areas. In the last 20 years our basic understanding of the mechanisms underlying plant tolerance and adaptation to saline environments has greatly improved owing to active development of advanced tools in molecular, genomics, and bioinformatics analyses. However, the full potential of investigative power has not been fully exploited, because the use of halophytes as model systems in plant salt tolerance research is largely neglected. The recent introduction of halophytic Arabidopsis-Relative Model Species (ARMS) has begun to compare and relate several unique genetic resources to the well-developed Arabidopsis model. In a search for candidates to begin to understand, through genetic analyses, the biological bases of salt tolerance, 11 wild relatives of Arabidopsis thaliana were compared: Barbarea verna, Capsella bursa-pastoris, Hirschfeldia incana, Lepidium densiflorum, Malcolmia triloba, Lepidium virginicum, Descurainia pinnata, Sisymbrium officinale, Thellungiella parvula, Thellungiella salsuginea (previously T. halophila), and Thlaspi arvense. Among these species, highly salt-tolerant (L. densiflorum and L. virginicum) and moderately salt-tolerant (M. triloba and H. incana) species were identified. Only T. parvula revealed a true halophytic habitus, comparable to the better studied Thellungiella salsuginea. Major differences in growth, water transport properties, and ion accumulation are observed and discussed to describe the distinctive traits and physiological responses that can now be studied genetically in salt stress research. 2010 The Author.

  18. Genetic and histological studies on the delayed systemic movement of Tobacco Mosaic Virus in Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Matus José

    2008-09-01

    Full Text Available Abstract Background Viral infections and their spread throughout a plant require numerous interactions between the host and the virus. While new functions of viral proteins involved in these processes have been revealed, current knowledge of host factors involved in the spread of a viral infection is still insufficient. In Arabidopsis thaliana, different ecotypes present varying susceptibilities to Tobacco mosaic virus strain U1 (TMV-U1. The rate of TMV-U1 systemic movement is delayed in ecotype Col-0 when compared with other 13 ecotypes. We followed viral movement through vascular tissue in Col-0 plants by electronic microscopy studies. In addition, the delay in systemic movement of TMV-U1 was genetically studied. Results TMV-U1 reaches apical leaves only after 18 days post rosette inoculation (dpi in Col-0, whereas it is detected at 9 dpi in the Uk-4 ecotype. Genetic crosses between Col-0 and Uk-4 ecotypes, followed by analysis of viral movement in F1 and F2 populations, revealed that this delayed movement correlates with a recessive, monogenic and nuclear locus. The use of selected polymorphic markers showed that this locus, denoted DSTM1 (Delayed Systemic Tobamovirus Movement 1, is positioned on the large arm of chromosome II. Electron microscopy studies following the virion's route in stems of Col-0 infected plants showed the presence of curved structures, instead of the typical rigid rods of TMV-U1. This was not observed in the case of TMV-U1 infection in Uk-4, where the observed virions have the typical rigid rod morphology. Conclusion The presence of defectively assembled virions observed by electron microscopy in vascular tissue of Col-0 infected plants correlates with a recessive delayed systemic movement trait of TMV-U1 in this ecotype.

  19. Real-Time Lineage Analysis to Study Cell Division Orientation in the Arabidopsis Shoot Meristem.

    Science.gov (United States)

    Tobin, Cory J; Meyerowitz, Elliot M

    2016-01-01

    Cells in the Arabidopsis shoot apical meristem are small and divide frequently throughout the life-time of the organism making them good candidates for studying the mechanisms of cell division in plants. But tracking these cell divisions requires multiple images to be taken of the same specimen over time which means the specimen must stay alive throughout the process. This chapter provides details on how to prepare plants for live imaging, keep them alive and growing through multiple time points, and how to process the data to extract cell boundary coordinates from three-dimensional images. PMID:26659961

  20. A Microarray Based Genomic Hybridization Method for Identification of New Genes in Plants: Case Analyses of Arabidopsis and Oryza

    Institute of Scientific and Technical Information of China (English)

    Chuanzhu Fan; Maria D. Vibranovski; Ying Chen; Manyuan Long

    2007-01-01

    To systematically estimate the gene duplication events in closely related species, we have to use comparative genomic approaches, either through genomic sequence comparison or comparative genomic hybridization (CGH). Given the scarcity of complete genomic sequences of plant species, in the present study we adopted an array based CGH to investigate gene duplications in the genus Arabidopsis. Fragment genomic DNA from four species, namely Arabidopsis thaliana, A. lyrata subsp. lyrata, A. lyrata subsp. petraea, and A. halleri, was hybridized to Affymetrix (Santa Clara, CA, USA) tiling arrays that are designed from the genomic sequences of A. thaliana. Pairwise comparisons of signal intensity were made to infer the potential duplicated candidates along each phylo-genetic branch. Ninety-four potential candidates of gene duplication along the genus were identified. Among them, the majority (69 of 94) were A. thaliana lineage specific. This result indicates that the array based CGH approach may be used to identify candidates of duplication in other plant genera containing closely related species, such as Oryza, particularly for the AA genome species. We compared the degree of gene duplication through retrotransposon between O. sativa and A. thaliana and found a strikingly higher number of chimera retroposed genes in rice. The higher rate of gene duplication through retroposition and other mechanisms may indicate that the grass species is able to adapt to more diverse environments.

  1. HYDROGEOLOGIC CASE STUDIES

    Science.gov (United States)

    Hydrogeology is the foundation of subsurface site characterization for evaluations of monitored natural attenuation (MNA). Three case studies are presented. Examples of the potentially detrimental effects of drilling additives on ground-water samples from monitoring wells are d...

  2. Objectivist case study research

    DEFF Research Database (Denmark)

    Ridder, Hanne Mette Ochsner; Fachner, Jörg

    2016-01-01

    In order to comprehend the impact of music therapy or music therapy processes, a researcher might look for an approach where the topic under investigation can be understood within a broader context. This calls for a rich inclusion of data and consequently a limited number of participants and may be...... achieved through the use of objectivist case study research. The strength of the case study design is that it allows for uncovering or suggesting causal relationships in real-life settings through an intensive and rich collection of data. According to Hilliard (1993), the opposite applies for extensive...... designs, in which a small amount of data is gathered on a large number of subjects. With the richness of data, the intensive design is ―the primary pragmatic reason for engaging in single-case or small N research‖ (p. 374) and for working from an idiographic rather than a nomothetic perspective....

  3. Nesidioblastosis: a case study.

    Science.gov (United States)

    Starbuck, A L

    1997-09-01

    Hypoglycemia is a common problem among neonates. Transient in nature, it usually resolves with an increase in glucose intake. However, as clinicians, we must recognize that prolonged hypoglycemia may be caused by increased insulin production. Nesidioblastosis is one cause of persistent hyperinsulinism of the newborn. This case study reviews fetal physiology, neonatal presentation, and treatment. PMID:9325879

  4. : Case studies: France

    OpenAIRE

    Bonerandi, Emmanuelle; Santamaria, Frédéric

    2005-01-01

    Case studies on territorial governance : urban region of Lyon (France) and the "Pays" policy (France) in the framework of the ESPON 2.3.2 project Études de cas sur la gouvernance territoriale : région urbaine de Lyon et politique des pays

  5. Rotordynamic Stability Case Studies

    OpenAIRE

    Choudhury Pranabesh

    2004-01-01

    In this article case studies are presented involving rotordynamic instability of modern high-speed turbomachinery relating the field data to analytical methods. The studies include oil seal related field problems, instability caused by aerodynamic cross-coupling in high-pressure, high-speed compressors, and hydrodynamic bearing instability resulting in subsynchronous vibration of a high-speed turbocharger. It has been shown that the analytical tools not only help in problem diagnostics, bu...

  6. Prague Case Study Report

    Czech Academy of Sciences Publication Activity Database

    Kostelecký, Tomáš; Patočková, Věra; Illner, Michal; Vobecká, Jana; Čermák, Daniel

    Aarau: Centre for Democracy Studies Aarau (ZDA), 2014 - (Widmer, C.; Kübler, D.), s. 131-177 ISBN 978-3-9524228-2-3 R&D Projects: GA AV ČR IAA700280802 Institutional support: RVO:68378025 Keywords : urban neighbourhods * regeneration * Prague Subject RIV: AD - Politology ; Political Sciences http://www.zdaarau.ch/dokumente/en/ZDA_Working-Papers/No3_RUN_case-studies_2014.pdf

  7. MIDAS case studies

    Energy Technology Data Exchange (ETDEWEB)

    Brusger, E.C.; Farber, M.A.; Sharpe Hayes, M.M.

    1989-07-01

    This series of three case studies illustrates the validity and usefulness of MIDAS, a microcomputer-based tool for integrated resource planning under uncertainty. The first, at Union Electric, serves to test and validate the model and to illustrate its use for demand/supply option evaluation. Focusing on nuclear plant life extension, the Virginia Power case demonstrates the model's extensive detail, particularly in the production cost and financial areas, as well as its flexibility in addressing approximately 70 uncertainty scenarios. Puget Sound Power Light, the third case, used MIDAS for the preparation of its integrated resource plan. A 108-endpoint decision tree illustrates the full power of the decision analysis capability.

  8. PageRank-based identification of signaling crosstalk from transcriptomics data: the case of Arabidopsis thaliana.

    Science.gov (United States)

    Omranian, Nooshin; Mueller-Roeber, Bernd; Nikoloski, Zoran

    2012-04-01

    The levels of cellular organization, from gene transcription to translation to protein-protein interaction and metabolism, operate via tightly regulated mutual interactions, facilitating organismal adaptability and various stress responses. Characterizing the mutual interactions between genes, transcription factors, and proteins involved in signaling, termed crosstalk, is therefore crucial for understanding and controlling cells' functionality. We aim at using high-throughput transcriptomics data to discover previously unknown links between signaling networks. We propose and analyze a novel method for crosstalk identification which relies on transcriptomics data and overcomes the lack of complete information for signaling pathways in Arabidopsis thaliana. Our method first employs a network-based transformation of the results from the statistical analysis of differential gene expression in given groups of experiments under different signal-inducing conditions. The stationary distribution of a random walk (similar to the PageRank algorithm) on the constructed network is then used to determine the putative transcripts interrelating different signaling pathways. With the help of the proposed method, we analyze a transcriptomics data set including experiments from four different stresses/signals: nitrate, sulfur, iron, and hormones. We identified promising gene candidates, downstream of the transcription factors (TFs), associated to signaling crosstalk, which were validated through literature mining. In addition, we conduct a comparative analysis with the only other available method in this field which used a biclustering-based approach. Surprisingly, the biclustering-based approach fails to robustly identify any candidate genes involved in the crosstalk of the analyzed signals. We demonstrate that our proposed method is more robust in identifying gene candidates involved downstream of the signaling crosstalk for species for which large transcriptomics data sets

  9. Use of Arabidopsis thaliana and Pseudomonas syringae in the Study of Plant Disease Resistance and Tolerance

    OpenAIRE

    Bent, Andrew F.; Kunkel, Barbara N.; Innes, Roger W.; Staskawicz, Brian J.

    1993-01-01

    The interaction between Arabidopsis thaliana and the bacterium Pseudomonas syringae is being developed as a model experimental system for plant pathology research. Race-specific ("gene-for-gene") resistance has been demonstrated for this interaction, and pathogen genes that determine avirulence have been isolated and characterized. Because certain lines of both Arabidopsis and soybean are resistant to bacteria carrying the avirulence genes avrRpt2 and avrB, extremely similar pathogen recognit...

  10. Corporate Governance. Case Studies

    OpenAIRE

    Manuel, Eduardo

    2007-01-01

    This paper pretends to do a theoretical approach of Corporate Governance, having as support some case studies about companies like Coca-Cola, Nokia, Microsoft, and Amazon.com. The methodology adopted for this work is based in information from these companies available in their websites and annual reports. I concluded that both companies show the corporate governance components according to their core business and their environmental business.

  11. Case study - Czechoslovakia

    International Nuclear Information System (INIS)

    In the lecture Case Study - Czechoslovakia with the sub-title 'Unified System of Personnel Preparation for Nuclear Programme in Czechoslovakia' the actual status and the current experience of NPP personnel training and preparation in Czechoslovakia are introduced. The above mentioned training system is presented and demonstrated by the story of a proxy person who is going to become shift engineer in a nuclear power plant in Czechoslovakia. (orig./HP)

  12. Case Studies - Cervical Cancer

    Centers for Disease Control (CDC) Podcasts

    2010-10-15

    Dr. Alan Waxman, a professor of obstetrics and gynecology at the University of New Mexico and chair of the American College of Obstetricians and Gynecologists (ACOG) committee for the underserved, talks about several case studies for cervical cancer screening and management.  Created: 10/15/2010 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Division of Cancer Prevention and Control (DCPC).   Date Released: 6/9/2010.

  13. Multigenerational versus single generation studies to estimate herbicide resistance fitness cost in Arabidopsis thaliana.

    Science.gov (United States)

    Roux, Fabrice; Camilleri, Christine; Bérard, Aurélie; Reboud, Xavier

    2005-10-01

    The evolution of resistance in response to pesticide selection is expected to be delayed if fitness costs are associated with resistance genes. The estimate of fitness costs usually involves comparing major growth traits of resistant versus susceptible individuals in the absence of pesticide. Ideally, a measure of changes in resistance allele frequency over several generations would allow the best estimate of the overall fitness cost of a resistance gene. In greenhouse conditions, we monitored the dynamics of the evolution of the frequencies of six herbicide-resistant mutations (acetolactate synthase, cellulose synthase, and auxin-induced target genes) in the model species Arabidopsis thaliana in a multigenerational study covering five to seven nonoverlapping generations. The microevolutionary dynamics in experimental populations indicated a mean fitness cost of 38%, 73%, and 94% for the ixr1-2, axr1-3, and axr2-1 resistances, respectively; no fitness cost for the csr1-1, and ixr2-1 resistances; and a transient advantage for the aux1-7 resistance. The result for the csr1-1 resistance contrasts with a cost of 37% based on total seed number in a previous study, demonstrating that single generation studies could have limitation for detecting cost. A positive frequency dependence for the fitness cost was also detected for the ixr1-2 resistance. The results are discussed in relation to the maintenance of polymorphism at resistance loci. PMID:16405169

  14. Sample Preparation of Arabidopsis thaliana Shoot Apices for Expression Studies of Photoperiod-Induced Genes.

    Science.gov (United States)

    Andrés, Fernando; Torti, Stefano; Vincent, Coral; Coupland, George

    2016-01-01

    Plants produce new organs from a population of pluripotent cells which are located in specific tissues called meristems. One of these meristems, the shoot apical meristem (SAM), gives rise to leaves during the vegetative phase and flowers during the reproductive phase. The transition from vegetative SAM to an inflorescence meristem (IM) is a dramatic developmental switch, which has been particularly well studied in the model species Arabidopsis thaliana. This developmental switch is controlled by multiple environmental signals such as day length (or photoperiod), and it is accompanied by changes in expression of hundreds of genes. A major interest in plant biology is to identify and characterize those genes which are regulated in the stem cells of the SAM in response to the photoperiodic signals. In this sense, techniques such as RNA in situ hybridization (RNA ISH) have been very successfully employed to detect the temporal and spatial expression patterns of genes in the SAM. This method can be specifically optimized for photoperiodic-flowering studies. In this chapter, we describe improved methods to generate plant material and histological samples to be combined with RNA ISH in flowering-related studies. PMID:26867617

  15. NOx trade. Case studies

    International Nuclear Information System (INIS)

    Some of the questions with respect to the trade of nitrogen oxides that businesses in the Netherlands have to deal with are dealt with: should a business buy or sell rights for NOx emission; which measures must be taken to reduce NOx emission; how much must be invested; and how to deal with uncertainties with regard to prices. Simulations were carried out with the MOSES model to find the answers to those questions. Results of some case studies are presented, focusing on the chemical sector in the Netherlands. Finally, the financial (dis)advantages of NOx trade and the related uncertainties for a single enterprise are discussed

  16. A Genome-wide Study of “Non-3UTR” Polyadenylation Sites in Arabidopsis thaliana

    Science.gov (United States)

    Guo, Cheng; Spinelli, Matthew; Liu, Man; Li, Qingshun Q.; Liang, Chun

    2016-01-01

    Alternative polyadenylation has been recognized as a key contributor of gene expression regulation by generating different transcript isoforms with altered 3′ ends. Although polyadenylation is well known for marking the end of a 3′ UTR, an increasing number of studies have reported previously less-addressed polyadenylation events located in other parts of genes in many eukaryotic organisms. These other locations include 5′ UTRs, introns and coding sequences (termed herein as non-3UTR), as well as antisense and intergenic polyadenlation. Focusing on the non-3UTR polyadenylation sites (n3PASs), we detected and characterized more than 11000 n3PAS clusters in the Arabidopsis genome using poly(A)-tag sequencing data (PAT-Seq). Further analyses suggested that the occurrence of these n3PASs were positively correlated with certain characteristics of their respective host genes, including the presence of spliced, diminutive or diverse beginning of 5′ UTRs, number of introns and whether introns have extreme lengths. The interaction of the host genes with surrounding genetic elements, like a convergently overlapped gene and associated transposable element, may contribute to the generation of a n3PAS as well. Collectively, these results provide a better understanding of n3PASs, and offer some new insights of the underlying mechanisms for non-3UTR polyadenylation and its regulation in plants. PMID:27301740

  17. The evolutionary response of plants to increased UV-B radiation: Field studies with Arabidopsis thaliana

    International Nuclear Information System (INIS)

    The response of a species to any environmental change is determined by both phenotypic and evolutionary adjustments. To date, the majority of research concerning the response of terrestrial plants to increased UV-B radiation has focused on phenotypic adjustments. Recently we have initiated field studies aimed at assessing genetic variation for UV-B sensitivity within a natural population of Arabidopsis thaliana. This population consists of at least eight discrete genotypes that have been confirmed by RAPD analysis. We used an incomplete block design to assess the impact of UV-B (ambient and ambient + 6 kJ) and PAR (low and high) on these genotypes. The high UV-B treatment caused a significant reduction in fruit number and plant height while the high PAR treatment caused a significant increase in these variables. In addition, there was a marginally significant (p=0.1) UV-B x PAR x maternal line interaction for fruit number, indicating that genetic variation for UV-B sensitivity within this population depends on the PAR environment. The combination of high UV-B and high PAR caused a change in fruit number (relative to the ambient UV-B/high PAR treatment) ranging from an increase of 24% to a decrease of 47%. This range was much smaller in the low PAR treatment. These results indicate the potential for increased UV-B radiation to act as an agent of natural selection within this population

  18. Polyol specificity of recombinant Arabidopsis thaliana sorbitol dehydrogenase studied by enzyme kinetics and in silico modeling

    Directory of Open Access Journals (Sweden)

    María Francisca eAguayo

    2015-02-01

    Full Text Available Polyols are enzymatically-produced plant compounds which can act as compatible solutes during periods of abiotic stress. NAD+-dependent SORBITOL DEHYDROGENASE (SDH, E.C. 1.1.1.14 from Arabidopsis thaliana L. (AtSDH is capable of oxidizing several polyols including sorbitol, ribitol and xylitol. In the present study, enzymatic assays using recombinant AtSDH demonstrated a higher specificity constant for xylitol compared to sorbitol and ribitol, all of which are C2 (S and C4 (R polyols. Enzyme activity was reduced by preincubation with ethylenediaminetetraacetic acid (EDTA, indicating a requirement for zinc ions. In humans, it has been proposed that sorbitol becomes part of a pentahedric coordination sphere of the catalytic zinc during the reaction mechanism. In order to determine the validity of this pentahedric coordination model in a plant SDH, homology modeling and Molecular Dynamics simulations of AtSDH ternary complexes with the three polyols were performed using crystal structures of human and Bemisia argentifolii (Genn. (Hemiptera: Aleyrodidae SDHs as scaffolds. The results indicate that the differences in interaction with structural water molecules correlate very well with the observed enzymatic parameters, validate the proposed pentahedric coordination of the catalytic zinc ion in a plant SDH, and provide an explanation for why AtSDH shows a preference for polyols with a chirality of C2 (S and C4 (R.

  19. Belowground neighbor perception in Arabidopsis thaliana studied by transcriptome analysis: roots of Hieracium pilosella cause biotic stress.

    Science.gov (United States)

    Schmid, Christoph; Bauer, Sibylle; Müller, Benedikt; Bartelheimer, Maik

    2013-01-01

    Root-root interactions are much more sophisticated than previously thought, yet the mechanisms of belowground neighbor perception remain largely obscure. Genome-wide transcriptome analyses allow detailed insight into plant reactions to environmental cues. A root interaction trial was set up to explore both morphological and whole genome transcriptional responses in roots of Arabidopsis thaliana in the presence or absence of an inferior competitor, Hieracium pilosella. Neighbor perception was indicated by Arabidopsis roots predominantly growing away from the neighbor (segregation), while solitary plants placed more roots toward the middle of the pot. Total biomass remained unaffected. Database comparisons in transcriptome analysis revealed considerable similarity between Arabidopsis root reactions to neighbors and reactions to pathogens. Detailed analyses of the functional category "biotic stress" using MapMan tools found the sub-category "pathogenesis-related proteins" highly significantly induced. A comparison to a study on intraspecific competition brought forward a core of genes consistently involved in reactions to neighbor roots. We conclude that beyond resource depletion roots perceive neighboring roots or their associated microorganisms by a relatively uniform mechanism that involves the strong induction of pathogenesis-related proteins. In an ecological context the findings reveal that belowground neighbor detection may occur independently of resource depletion, allowing for a time advantage for the root to prepare for potential interactions. PMID:23967000

  20. Vertebral Angiosarcoma. Case Study.

    Science.gov (United States)

    Guzik, Grzegorz

    2015-01-01

    Bone angiosarcomas, especially vertebral angiosarcomas, are very rare. There are no studies based on large clinical samples in the literature, and only a few single case reports can be found. The symptoms of the disease are not specific. It is usually detected incidentally or at a late stage when pathological vertebral fractures or neurological complications occur. Diagnostic imaging and history help to recognize the tumour behind the symptoms, but do not allow accurate clinical diagnosis. The basis for a diagnosis is the histopathological examination supported by immunohistochemistry (IHC) assays. The case of a 26-year-old woman with an angiosarcoma involving the eighth thoracic vertebra we report reflects diagnostic problems adversely affecting the efficacy and accuracy of treatment offered to patients. The patient underwent three surgeries of the spine, including two biopsies. A needle biopsy did not provide sufficient information for the diagnosis. An open excisional biopsy, which at the same time temporarily reduced neurological deficits in the patient, was the only chance to obtain an accurate diagnosis. The third surgery was posterior decompression of the spinal cord due to the rapidly escalating paraparesis. It was not until 8 weeks later that the final diagnosis was established. At that time, the patient could not be qualified for any supplementary treatment. The patient died in hospital 6 months after the onset of disease. PMID:26468177

  1. Goiania incident case study

    International Nuclear Information System (INIS)

    The reasons for wanting to document this case study and present the findings are simple. According to USDOE technical risk assessments (and our own initial work on the Hanford socioeconomic study), the likelihood of a major accident involving exposure to radioactive materials in the process of site characterization, construction, operation, and closure of a high-level waste repository is extremely remote. Most would agree, however, that there is a relatively high probability that a minor accident involving radiological contamination will occur sometime during the lifetime of the repository -- for example, during transport, at an MRS site or at the permanent site itself during repacking and deposition. Thus, one of the major concerns of the Yucca Mountain Socioeconomic Study is the potential impact of a relatively minor radiation-related accident. A large number of potential impact of a relatively minor radiation-related accident. A large number of potential accident scenarios have been under consideration (such as a transportation or other surface accident which results in a significant decline in tourism, the number of conventions, or the selection of Nevada as a retirement residence). The results of the work in Goiania make it clear, however, that such a significant shift in established social patterns and trends is not likely to occur as a direct outcome of a single nuclear-related accident (even, perhaps, a relatively major one), but rather, are likely to occur as a result of the enduring social interpretations of such an accident -- that is, as a result of the process of understanding, communicating, and socially sustaining a particular set of associations with respect to the initial incident

  2. Natural Learning Case Study Archives

    Science.gov (United States)

    Lawler, Robert W.

    2015-01-01

    Natural Learning Case Study Archives (NLCSA) is a research facility for those interested in using case study analysis to deepen their understanding of common sense knowledge and natural learning (how the mind interacts with everyday experiences to develop common sense knowledge). The database comprises three case study corpora based on experiences…

  3. FMCT verification: Case studies

    International Nuclear Information System (INIS)

    Full text: How to manage the trade-off between the need for transparency and the concern about the disclosure of sensitive information would be a key issue during the negotiations of FMCT verification provision. This paper will explore the general concerns on FMCT verification; and demonstrate what verification measures might be applied to those reprocessing and enrichment plants. A primary goal of an FMCT will be to have the five declared nuclear weapon states and the three that operate unsafeguarded nuclear facilities become parties. One focus in negotiating the FMCT will be verification. Appropriate verification measures should be applied in each case. Most importantly, FMCT verification would focus, in the first instance, on these states' fissile material production facilities. After the FMCT enters into force, all these facilities should be declared. Some would continue operating to produce civil nuclear power or to produce fissile material for non- explosive military uses. The verification measures necessary for these operating facilities would be essentially IAEA safeguards, as currently being applied to non-nuclear weapon states under the NPT. However, some production facilities would be declared and shut down. Thus, one important task of the FMCT verifications will be to confirm the status of these closed facilities. As case studies, this paper will focus on the verification of those shutdown facilities. The FMCT verification system for former military facilities would have to differ in some ways from traditional IAEA safeguards. For example, there could be concerns about the potential loss of sensitive information at these facilities or at collocated facilities. Eventually, some safeguards measures such as environmental sampling might be seen as too intrusive. Thus, effective but less intrusive verification measures may be needed. Some sensitive nuclear facilities would be subject for the first time to international inspections, which could raise concerns

  4. Termination: A Case Study.

    Science.gov (United States)

    Friedberg, Ahron L

    2015-12-01

    In this article I posit and examine certain criteria and qualities for ending an analysis. The case study describes the end phase of a four-year psychoanalysis in which the patient's decision to move to another area forced the end of his analysis. We continued to explore and work through his core neurotic conflicts that included issues of competitive rivalry, dominance and submission, control, and anxiety about birth and death. A shift in the transference from me as a negative father to me as a supportive but competitive older brother was also examined in the context of ending treatment as well as other aspects of the transference. In addition, we analyzed the meaning of his ending treatment based on an extra-analytic circumstance. In discussing this phase of treatment, the definition and history of the term "termination" and its connotations are reviewed. Various criteria for completing an analysis are examined, and technical observations about this phase of treatment are investigated. It was found that while a significant shift in the transference occurred in this phase of the patient's analysis, conflicts related to the transference were not "resolved" in the classical sense. Terminating treatment was considered as a practical matter in which the patient's autonomy and sense of choice were respected and analyzed. PMID:26583444

  5. Exploring valid reference genes for quantitative real - time rt - pce studies of hydrogenperoxide signaling in arabidopsis

    International Nuclear Information System (INIS)

    Hydrogen peroxide (H/sub 2/O/sub 2/ ) acts as a signaling molecule modulating the expression of various genes in plants. However, the reference gene(s) used for gene expression analysis of H/sub 2/O/sub 2/ signaling is still arbitrary. A reliable result obtained by quantitative real-time RT-PCR (RT-qPCR) highly depends on accurate transcript normalization using stably expressed reference genes, whereas the inaccurate normalization could easily lead to the false conclusions. In this report, by using geNorm and NormFinder algorithms, 12 candidate reference genes were evaluated and compared in root and shoot tissues of Arabidopsis upon different doses of H/sub 2/O/sub 2/. The results revealed that, in our experimental conditions, three novel reference genes (TIP41-like, UKN, and UBC21) were identified and validated as suitable reference genes for RT-qPCR normalization in both root and shoot tissues under oxidative stress. This conclusion was further confirmed by publicly available microarray data of methyl viologen and drought stress. In comparison with a single reference gene (EF-1a), the expression pattern of ZAT12 modulated by H/sub 2/O/sub 2/, when using TIP41-like, UKN, and UBC21 as multiple reference gene(s), was similar with the previous reports by using northern blotting. Thus, we proposed that these three reference genes might be good candidates for other researchers to include in their reference gene validation in gene expression studies under H/sub 2/O/sub 2/ related oxidative stress. (author)

  6. Teaching Pharmacology by Case Study.

    Science.gov (United States)

    Jordan, Sue

    1997-01-01

    Using pharmacology case studies with nursing students encourages theory-practice links and infuses real-life content. Cases provide rich qualitative data for evaluating curriculum. However, they are not a substitute for evidence-based practice. (SK)

  7. Global and targeted proteomics in Arabidopsis thaliana: A study of secondary metabolism and phytohormone signaling

    OpenAIRE

    Slade Jr, William O

    2013-01-01

    Proteomics is defined as a tool to explore how proteins control and regulate important molecular and physiological processes. Further, peptide-centric approaches, or bottom-up methods, provide more comprehensive coverage of a proteome compared to whole-protein approaches. This body of work assesses the technical feasibility of several bottom-up proteomics technologies applied to Arabidopsis thaliana, including gel-based methods, those that require peptide derivitization, and those that do n...

  8. A Preliminary Study on a Specifically Expressed Arabidopsis Promotor in Vascular Bundle

    Institute of Scientific and Technical Information of China (English)

    谷运红; 谢传晓; 吴丽芳; 余增亮; 秦广雍; 霍裕平

    2003-01-01

    From a population of about 3500 single plants in Arabidopsis promoter trapping bank, one plant whose GUS-gene had been specifically expressed in vascular bundle, was screened by the method of gus tissue staining. The T-DNA flanking sequence was amplified using TAILPCR. This band will be purified and connected to TA cloning vector. After sequencing and searching in the genebank, its function will be demonatrated through transformation.

  9. Chromosome landmarks as tools to study the genome of Arabidopsis thaliana

    Czech Academy of Sciences Publication Activity Database

    Široký, Jiří

    2008-01-01

    Roč. 120, 3-4 (2008), s. 202-209. ISSN 1424-8581 R&D Projects: GA ČR(CZ) GA522/06/0380; GA MŠk(CZ) LC06004 Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702 Keywords : Arabidopsis * chromosomes * FISH Subject RIV: BO - Biophysics Impact factor: 1.965, year: 2008

  10. Optimization of transient expression procedures in Catharanthus roseus and Arabidopsis thaliana for subcellular localization studies

    OpenAIRE

    Ribeiro, Diana Margarida da Costa

    2010-01-01

    Dissertação de mestrado em Biotecnologia e Bio-Empreendedorismo em Plantas Aromáticas e Medicinais Nowadays, the availability of much gene sequence information demands the development of tools for their fast characterization at the protein level, where function actually resides. Here, the interest in the characterization of certain of the known Arabidopsis class III peroxidase (Prx) genes, as well as the interest in the characterization of candidate genes implicated in the meta...

  11. Intercultural Communicative Case Study

    Institute of Scientific and Technical Information of China (English)

    吴冬梅

    2009-01-01

    The essay is mainly about the author's comprehension of cultural differences and intercultural communication after reading the book Communication Between Cultures.In addition,the author also analyses three cases with the theories and approaches mentioned in Communication Between Cultures.

  12. Case Study: Case Studies and the Flipped Classroom

    Science.gov (United States)

    Herreid, Clyde Freeman; Schiller, Nancy A.

    2013-01-01

    This column provides original articles on innovations in case study teaching, assessment of the method, as well as case studies with teaching notes. This month's issue discusses the positive and negative aspects of the "flipped classroom." In the flipped classroom model, what is normally done in class and what is normally done as…

  13. Customs Modernization Initiatives : Case Studies

    OpenAIRE

    De Wulf, Luc; José B. Sokol

    2004-01-01

    This volume presents case studies of customs modernization initiatives in eight developing countries: Bolivia, Ghana, Morocco, Mozambique, Peru, the Philippines, Turkey, and Uganda. The purpose of these case studies was to obtain a firsthand view of how these countries undertook customs reforms and to assess their success. The overall lessons learned from these studies are presented in cha...

  14. Theory Testing Using Case Studies

    DEFF Research Database (Denmark)

    Møller, Ann-Kristina Løkke; Dissing Sørensen, Pernille

    2014-01-01

    The appropriateness of case studies as a tool for theory testing is still a controversial issue, and discussions about the weaknesses of such research designs have previously taken precedence over those about its strengths. The purpose of the paper is to examine and revive the approach of theory...... testing using case studies, including the associated research goal, analysis, and generalisability. We argue that research designs for theory testing using case studies differ from theorybuilding case study research designs because different research projects serve different purposes and follow different...

  15. Theory testing using case studies

    DEFF Research Database (Denmark)

    Dissing Sørensen, Pernille; Løkke Nielsen, Ann-Kristina

    Case studies may have different research goals. One such goal is the testing of small-scale and middle-range theories. Theory testing refers to the critical examination, observation, and evaluation of the 'why' and 'how' of a specified phenomenon in a particular setting. In this paper, we focus on...... the strengths of theory-testing case studies. We specify research paths associated with theory testing in case studies and present a coherent argument for the logic of theoretical development and refinement using case studies. We emphasize different uses of rival explanations and their implications...... for research design. Finally, we discuss the epistemological logic, i.e., the value to larger research programmes, of such studies and, following Lakatos, conclude that the value of theory-testing case studies lies beyond naïve falsification and in their contribution to developing research programmes...

  16. Information flow during gene activation by signaling molecules: ethylene transduction in Arabidopsis cells as a study system

    Directory of Open Access Journals (Sweden)

    Díaz José

    2009-05-01

    Full Text Available Abstract Background We study root cells from the model plant Arabidopsis thaliana and the communication channel conformed by the ethylene signal transduction pathway. A basic equation taken from our previous work relates the probability of expression of the gene ERF1 to the concentration of ethylene. Results The above equation is used to compute the Shannon entropy (H or degree of uncertainty that the genetic machinery has during the decoding of the message encoded by the ethylene specific receptors embedded in the endoplasmic reticulum membrane and transmitted into the nucleus by the ethylene signaling pathway. We show that the amount of information associated with the expression of the master gene ERF1 (Ethylene Response Factor 1 can be computed. Then we examine the system response to sinusoidal input signals with varying frequencies to determine if the cell can distinguish between different regimes of information flow from the environment. Our results demonstrate that the amount of information managed by the root cell can be correlated with the frequency of the input signal. Conclusion The ethylene signaling pathway cuts off very low and very high frequencies, allowing a window of frequency response in which the nucleus reads the incoming message as a sinusoidal input. Out of this window the nucleus reads the input message as an approximately non-varying one. From this frequency response analysis we estimate: a the gain of the system during the synthesis of the protein ERF1 (~-5.6 dB; b the rate of information transfer (0.003 bits during the transport of each new ERF1 molecule into the nucleus and c the time of synthesis of each new ERF1 molecule (~21.3 s. Finally, we demonstrate that in the case of the system of a single master gene (ERF1 and a single slave gene (HLS1, the total Shannon entropy is completely determined by the uncertainty associated with the expression of the master gene. A second proposition shows that the Shannon entropy

  17. Case Studies on Sustainable Buildings

    OpenAIRE

    Hui, Sam CM

    2005-01-01

    This web site is developed with the aim to promote sustainable design and planning of buildings. A knowledge base of case studies and resources has been established to illustrate the sustainable design strategies and features in realistic building projects all over the world. The database of case studies can be searched by project names, locations, design strategies and design features.

  18. Three Community College Case Studies

    Science.gov (United States)

    Wojtysiak, Joseph; Sutton, William J., II; Wright, Tommy; Brantley, Linda

    2011-01-01

    This article presents three case studies that focus on specific projects that are underway or have been completed. In the first case study, Joseph Wojtysiak and William J. Sutton, II discuss the Green Center of Central Pennsylvania, which is designed to serve as the state's preeminent source for education, training and public information about…

  19. The Big Read: Case Studies

    Science.gov (United States)

    National Endowment for the Arts, 2009

    2009-01-01

    The Big Read evaluation included a series of 35 case studies designed to gather more in-depth information on the program's implementation and impact. The case studies gave readers a valuable first-hand look at The Big Read in context. Both formal and informal interviews, focus groups, attendance at a wide range of events--all showed how…

  20. Plant-in-chip: Microfluidic system for studying root growth and pathogenic interactions in Arabidopsis

    Science.gov (United States)

    Parashar, Archana; Pandey, Santosh

    2011-06-01

    We report a microfluidic platform for the hydroponic growth of Arabidopsis plants with high-resolution visualization of root development and root-pathogen interactions. The platform comprises a set of parallel microchannels with individual input/output ports where 1-day old germinated seedlings are initially placed. Under optimum conditions, a root system grows in each microchannel and its images are recorded over a 198-h period. Different concentrations of plant growth media show different root growth characteristics. Later, the developed roots are inoculated with two plant pathogens (nematodes and zoospores) and their physicochemical interactions with the live root systems are observed.

  1. Kickstarter - A Case Study

    OpenAIRE

    Willumsen, Ea Christina; Byg-Fabritius, Edith Ursula Tvede

    2013-01-01

    This paper is an investigation of the online crowdfunding platform Kickstarter, and discusses what makes a Kickstarter campaign successful. Two previous Kickstarter campaigns have been debated in focus groups interviews, as the basis of the study is a reception analysis of two focus group interviews. Ee apply theories from Schrøder (2000) and Batey (2008) to our analysis to study how the campaigns appeal to their backers. By drawing on ideas from Rogers (2003) and Pine & Gilmore (1998), we fu...

  2. Case study - Argentina

    International Nuclear Information System (INIS)

    Antecedents and experience of nuclear activities in Argentina; the Atomic Energy Commission (CNEA). First development and research activities. Research reactors and radioisotopes plants. Health physics and safety regulations. - Feasibility studies for the first nuclear power plant. Awarding the first plant CNA I (Atucha I). Relevant data related to the different project stages. Plant performance. - Feasibility study for the second nuclear power plant. Awarding the second plant CNE (Central Nuclear Embalse). Relevant data related to established targets. Differences compared with the first station targets. Local participation. Plant performance. (orig./GL)

  3. Structural and Functional Studies of the Mitochondrial Cysteine Desulfurase from Arabidopsis thaliana

    Institute of Scientific and Technical Information of China (English)

    Valeria R; Turowski; Maria V.Busi; Diego F.Gomez-Casati

    2012-01-01

    AtNfs1 is the Arabidopsis thaliana mitochondrial homolog of the bacterial cysteine desulfurases NifS and lscS,having an essential role in cellular Fe-S cluster assembly.Homology modeling of AtNfs1m predicts a high global similarity with E.coli IscS showing a full conservation of residues involved in the catalytic site,whereas the chloroplastic AtNfs2 is more similar to the Synechocystis sp.SufS.Pull-down assays showed that the recombinant mature form,AtNfs1m,specifically binds to Arabidopsis frataxin (AtFH).A hysteretic behavior,with a lag phase of several minutes,was observed and hysteretic parameters were affected by pre-incubation with AtFH.Moreover,AtFH modulates AtNfs1m kinetics,increasing Vmax and decreasing the S0.5 value for cysteine.Results suggest that AtFH plays an important role in the early steps of Fe-S cluster formation by regulating AtNfs1 activity in olant mitochondria.

  4. Geostatistical case studies

    International Nuclear Information System (INIS)

    The objective of this volume of contributed chapters is to present a series of applications of geostatistics. These range from a careful variographic analysis on uranium data, through detailed studies on geologically complex deposits, right up to the latest nonlinear methods applied to deposits with highly skewed data contributions. Applications of new techniques such as the external drift method for combining well data with seismic information have also been included. The volume emphasizes geostatistics in practice. Notation has been kept to a minimum and mathematical details have been relegated to annexes

  5. Case Studies in Science Ethics

    Science.gov (United States)

    Williams, Karen

    2010-03-01

    Everyone in science should have ethics education training. I have seen graduate students taken advantage of by their mentors. Many of us have seen misconduct...but what should we do about it? Young scientists are often unaware of the rules in science and make mistakes because of their ignorance of the rules in that particular field of study. Then there are an increasing number of cases in the news of overt cases of misrepresentation in science. All are welcome to attend this discussion of case studies. A case study on topics such as: how to treat data properly, how our values in science affect our work, who gets authorship on scientific papers, who is first author on a paper, what you should do if you uncover misconduct or plagiarism in your university, and we will discuss the scientist's role in society. This will be a painless, non-confrontational small group, then large group discussion of each case

  6. Advances in Arabidopsis research in China from 2006 to 2007

    Institute of Scientific and Technical Information of China (English)

    LIANG Yan; ZUO JianRu; YANG WeiCai

    2007-01-01

    @@ Arabidopsis thaliana, a model plant species, has a number of advantages over other plant species as an experimental organism due to many of its genetic and genomic features. The Chinese Arabidopsis community has made significant contributions to plant biology research in recent years[1,2]. In 2006, studies of plant biology in China received more attention than ever before, especially those pertaining to Arabidopsis research. Here we briefly summarize recent advances in Arabidopsis research in China.

  7. Teaching astronomy with case studies

    Science.gov (United States)

    Slater, Timothy F.

    2015-11-01

    Breaking the students into small, collaborative learning groups to solve a meaningful task together is one of the most successful and fully evaluated teaching techniques implemented over the last century. Although there are many ways to accomplish small group learning, a long-standing and consistently successful collaborative class activity is to use the case study teaching strategy. The use of case studies is common in medical schools and law schools, but not so common in the teaching of astronomy. Case studies create meaningful conversations among students and with the professor by focusing on life-like dilemmas to be solved. Case study tasks ask audience members to synthesize several ideas or evaluate scenarios that have not been explicitly presented to them in the lecture or in available readings.

  8. Nasopharyngeal Case-Control Study

    Science.gov (United States)

    A case-control study conducted in Taiwan between 1991-1994 among approximately 1,000 individuals to examine the role of viral, environmental, and genetic factors associated with the development of nasopharyngeal carcinoma

  9. HYDROGEOLOGIC CASE STUDIES (CHICAGO, IL)

    Science.gov (United States)

    Hydrogeology is the foundation of subsurface site characterization for evaluations of monitored natural attenuation (MNA). Three case studies are presented. Examples of the potentially detrimental effects of drilling additives on ground-water samples from monitoring wells are d...

  10. HYDROGEOLOGIC CASE STUDIES (DENVER PRESENTATION)

    Science.gov (United States)

    Hydrogeology is the foundation of subsurface site characterization for evaluations of monitored natural attenuation (MNA). Three case studies are presented. Examples of the potentially detrimental effects of drilling additives on ground-water samples from monitoring wells are d...

  11. Hydrogeologic Case Studies (Seattle, WA)

    Science.gov (United States)

    Hydrogeology is the foundation of subsurface site characterization for evaluations of monitored natural attenuation (MNA). Three case studies are presented. Examples of the potentially detrimental effects of drilling additives on ground-water samples from monitoring wells are d...

  12. Ultrastructural study of maturing pollen in Arabidopsis thaliana (L. Heynh. (Brassicaceae

    Directory of Open Access Journals (Sweden)

    Krystyna Zając

    2014-02-01

    Full Text Available Ultrastructural changes in Arabidopsis thaliana pollen, between late microspore stage and mature pollen stage were described. When the generative cell was peeled off from the intine, it was of spherical shape and had all usual organelles with the exception of plastids. The cytoplasm transformation of the vegetative cell included an increase in the number of mitochondria and changes in the accumulation of starch and lipid bodies. The starch plastids were observed at the bicellular and early tricellular pollen stages and next starch was utilized during the maturation procces. The lipid bodies of the vegetative cell form a very regular sheath around the generative cell and then, around the sperm cells. Before anthesis the lipid bodies were dispersed within the whole vegetative cell cytoplasm.

  13. Protocols for Studying Protein Stability in an Arabidopsis Protoplast Transient Expression System.

    Science.gov (United States)

    Planchais, Séverine; Camborde, Laurent; Jupin, Isabelle

    2016-01-01

    Protein stability influences many aspects of biology, and measuring their stability in vivo can provide important insights into biological systems.This chapter describes in details two methods to assess the stability of a specific protein based on its transient expression in Arabidopsis protoplasts. First, a pulse-chase assay based on radioactive metabolic labeling of cellular proteins, followed by immunoprecipitation of the protein of interest. The decrease in radioactive signal is monitored over time and can be used to determine the protein's half-life.Alternatively, we also present a nonradioactive assay based on the use of reporter proteins, whose ratio can be quantified. This assay can be used to determine the relative stability of a protein of interest under specific conditions. PMID:27424754

  14. A Study of the Blue-Light-Dependent Phosphorylation, Degradation, and Photobody Formation of Arabidopsis CRY2

    Institute of Scientific and Technical Information of China (English)

    Ze-Cheng Zuo; Ying-Ying Meng; Xu-Hong Yu; Zeng-Lin Zhang; De-Shun Feng; Shih-Fan Sun; Bin Liu; Chen-Tao Lin

    2012-01-01

    Arabidopsis cryptochrome 2 (CRY2) is a blue-light receptor mediating blue-light inhibition of hypocotyl elongation and photoperiodic promotion of floral initiation.CRY2 is a constitutive nuclear protein that undergoes blue-light-dependent phosphoryiation,ubiquitination,photobody formation,and degradation in the nucleus,but the relationship between these blue-light-dependent events remains unclear.it has been proposed that CRY2 phosphorylation triggers a conformational change responsible for the subsequent ubiquitination and photobody formation,leading to CRY2 function and/or degradation.We tested this hypothesis by a structure-function study,using mutant CRY2-GFP fusion proteins expressed in transgenic Arabidopsis.We show that changes of lysine residues of the NLS (Nuclear Localization Signal) sequence of CRY2 to arginine residues partially impair the nuclear importation of the CRY2K541R and CRY2K554/5R mutant proteins,resulting in reduced phosphorylation,physiological activities,and degradation in response to blue light.In contrast to the wild-type CRY2 protein that forms photobodies exclusively in the nucleus,the CRY2K541R and CRY2K554/5R mutant proteins form protein bodies in both the nucleus and cytosol in response to blue light.These results suggest that photoexcited CRY2 molecules can aggregate to form photobody-like structure without the nucleus-dependent protein modifications or the association with the nuclear CRY2-interacting proteins.Taken together,the observation that CRY2 forms photobodies markedly faster than CRY2 phosphorylation in response to blue light,we hypothesize that the photoexcited cryptochromes form oligomers,preceding other biochemical changes of CRY2,to facilitate photobody formation,signal amplification,and propagation,as well as desensitization by degradation.

  15. Sternocleidomastoid syndrome: a case study

    OpenAIRE

    Missaghi, Babak

    2004-01-01

    This article presents a case study of a patient diagnosed with dysfunction of the sternocleidomastoid (SCM) muscle, a condition which can result in head and face pain, nausea, dizziness, coryza, and lacrimation. In this particular case, the SCM muscle had developed tightness and weakness with presence of multiple trigger points within both heads. A combination of passive and active treatments were utilized to successfully treat this condition.

  16. Kenya Groundwater Governance Case Study

    OpenAIRE

    Mumma, Albert; Lane, Michael; Kairu, Edward; Tuinhof, Albert; Hirji, Rafik

    2011-01-01

    This report presents a case study on groundwater governance in Kenya. The objectives of the study were to: (a) describe groundwater resource and socioeconomic settings for four selected aquifers; (b) describe governance arrangements for groundwater management in Kenya; and (c) identify the relevance of these arrangements for planning and implementing climate change mitigation measures. The ...

  17. Case Study on Logistics Performance

    OpenAIRE

    Sorooshian, Shahryar; Jambulingam, Manimekalai; Dodangeh, Javad

    2013-01-01

    The paper presents research carried out at a medium‐size manufacturing organization in east Asia. The study tries to highlight the importance of supply chain management; specifically, our aim for this study is to understand logistics and performance measurement in the logistics and supply chain, and we include a theoretical discussion of online data collected and a case study of the logistic performance of a real organization. The study also examines the performance of the selected company, i...

  18. eCompetence Case Studies

    DEFF Research Database (Denmark)

    Jensen, Helle Bækkelund

    2006-01-01

    In this paper we present some details of the processes undertaken in the European eCompetence Initiative. We present two illustrative and representative case studies. The research aims to identify and understand patterns of individual and organisational eCompetence approaches.......In this paper we present some details of the processes undertaken in the European eCompetence Initiative. We present two illustrative and representative case studies. The research aims to identify and understand patterns of individual and organisational eCompetence approaches....

  19. Case Study on Logistics Performance

    Directory of Open Access Journals (Sweden)

    Shahryar Sorooshian

    2013-05-01

    Full Text Available The paper presents research carried out at a medium‐size manufacturing organization in east Asia. The study tries to highlight the importance of supply chain management; specifically, our aim for this study is to understand logistics and performance measurement in the logistics and supply chain, and we include a theoretical discussion of online data collected and a case study of the logistic performance of a real organization. The study also examines the performance of the selected company, identifies the problems and provides recommendations for improvements. This study can be a guide for business advisers and those interested in analysing company performance, especially from a logistics viewpoint. We also suggest the methodology of this case study for those who want to have a better understanding of a business environment before starting their own business, or for benchmarking practice during strategic planning.

  20. Teaching Case: Enterprise Architecture Specification Case Study

    Science.gov (United States)

    Steenkamp, Annette Lerine; Alawdah, Amal; Almasri, Osama; Gai, Keke; Khattab, Nidal; Swaby, Carval; Abaas, Ramy

    2013-01-01

    A graduate course in enterprise architecture had a team project component in which a real-world business case, provided by an industry sponsor, formed the basis of the project charter and the architecture statement of work. The paper aims to share the team project experience on developing the architecture specifications based on the business case…

  1. Machine learning-based differential network analysis: a study of stress-responsive transcriptomes in Arabidopsis.

    Science.gov (United States)

    Ma, Chuang; Xin, Mingming; Feldmann, Kenneth A; Wang, Xiangfeng

    2014-02-01

    Machine learning (ML) is an intelligent data mining technique that builds a prediction model based on the learning of prior knowledge to recognize patterns in large-scale data sets. We present an ML-based methodology for transcriptome analysis via comparison of gene coexpression networks, implemented as an R package called machine learning-based differential network analysis (mlDNA) and apply this method to reanalyze a set of abiotic stress expression data in Arabidopsis thaliana. The mlDNA first used a ML-based filtering process to remove nonexpressed, constitutively expressed, or non-stress-responsive "noninformative" genes prior to network construction, through learning the patterns of 32 expression characteristics of known stress-related genes. The retained "informative" genes were subsequently analyzed by ML-based network comparison to predict candidate stress-related genes showing expression and network differences between control and stress networks, based on 33 network topological characteristics. Comparative evaluation of the network-centric and gene-centric analytic methods showed that mlDNA substantially outperformed traditional statistical testing-based differential expression analysis at identifying stress-related genes, with markedly improved prediction accuracy. To experimentally validate the mlDNA predictions, we selected 89 candidates out of the 1784 predicted salt stress-related genes with available SALK T-DNA mutagenesis lines for phenotypic screening and identified two previously unreported genes, mutants of which showed salt-sensitive phenotypes. PMID:24520154

  2. The reflexive case study method

    DEFF Research Database (Denmark)

    Rittenhofer, Iris

    2015-01-01

    This paper extends the international business research on small to medium-sized enterprises (SME) at the nexus of globalization. Based on a conceptual synthesis across disciplines and theoretical perspectives, it offers management research a reflexive method for case study research of postnational...

  3. Study of biological effects induced in Arabidopsis thaliana following uranium exposure, including mixed exposure to cadmium or external gamma radiation: applying a multi-biomarkers approach

    OpenAIRE

    Vanhoudt, Nathalie

    2009-01-01

    The aim of this study was first to investigate uranium toxicity effects and to unravel mechanisms by which plants respond to uranium stress. In a next phase, the influence of secondary stressors on uranium induced effects was investigated. The highest uranium concentration of 100 µM uranium is extremely toxic for Arabidopsis thaliana plants with a completely inhibited growth, a fully disturbed nutrient profile, wilting and although making an effort to increase antioxidative defense, suffering...

  4. Case Studies on Crossborder Ecotrade

    OpenAIRE

    Asian Development Bank

    2012-01-01

    This compilation of four country case studies provides a comprehensive understanding of challenges, good practices, and lessons learnt under different situations. In the Lao People’s Democratic Republic, a cross-border vegetable trade agreement with its neighboring, Thailand, aided in stabilizing market prices and provided financial benefits to local contract farmers. Similarly, organic certification and geographic indication of sugar palm in Cambodia linked local farmers to the global market...

  5. A Comparative Study of Ethylene Emanation upon Nitrogen Deficiency in Natural Accessions of Arabidopsis thaliana

    Science.gov (United States)

    De Gernier, Hugues; De Pessemier, Jérôme; Xu, Jiajia; Cristescu, Simona M.; Van Der Straeten, Dominique; Verbruggen, Nathalie; Hermans, Christian

    2016-01-01

    An original approach to develop sustainable agriculture with less nitrogen fertilizer inputs is to tackle the cross-talk between nitrogen nutrition and plant growth regulators. In particular the gaseous hormone, ethylene, is a prime target for that purpose. The variation of ethylene production in natural accessions of the model species Arabidopsis thaliana was explored in response to the nitrate supply. Ethylene was measured with a laser-based photoacoustic detector. First, experimental conditions were established with Columbia-0 (Col-0) accession, which was grown in vitro on horizontal plates across a range of five nitrate concentrations (0.5, 1, 2.5, 5, or 10 mM). The concentrations of 1 and 10 mM nitrate were retained for further characterization. Along with a decrease of total dry biomass and higher biomass allocation to the roots, the ethylene production was 50% more important at 1 mM than at 10 mM nitrate. The total transcript levels of 1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID SYNTHASES (ACS) in roots and those of ACC OXIDASES (ACO) in shoots increased by 100% between the same treatments. This was mainly due to higher transcript levels of ACS6 and of ACO2 and ACO4 respectively. The assumption was that during nitrogen deficiency, the greater biomass allocation in favor of the roots was controlled by ethylene being released in the shoots after conversion of ACC originating from the roots. Second, biomass and ethylene productions were measured in 20 additional accessions. Across all accessions, the total dry biomass and ethylene production were correlated negatively at 1 mM but positively at 10 mM nitrate. Furthermore, polymorphism was surveyed in ACC and ethylene biosynthesis genes and gene products among accessions. Very few substitutions modifying the amino acids properties in conserved motifs of the enzymes were found in the accessions. Natural variation of ethylene production could be further explored to improve Nitrogen Use Efficiency (NUE), in particular by

  6. A case study of Impetigo

    Directory of Open Access Journals (Sweden)

    Mansouri P

    1993-05-01

    Full Text Available This is a report of a case study on 234 patients with impetigo who referred to Razi Dermatology Hospital from April to November, 1989. Treatment was started immediately after obtaining direct smear and performing culture and antibiotic sensitivity test. The most common organism responsible for impetigo was the coagulase-positive staphylococcus (71%. In 13.7% of the cases, the coagulase-negative staphylococcus was grown on culture media, but none of the cultures showed streptococcus as the main organism. Treatment was started with oral penicillin V, oral erythromycin, benzathine penicillin G injection, oral cephalexin, and topical fuccidin. Clinical and bacteriological evaluation after 3-7 days showed that it is preferable to use oral cephalexin instead of other protocols such as oral erythromycin, which has previously been the drug of choice for impetigo. In addition, topical fuccidin with a 75% curative rate was the first drug for treatment, with the same effect as the oral cephalexin

  7. Case studies in canonical stewardship.

    Science.gov (United States)

    Cafardi, N P; Hite, J

    1985-11-01

    In facing the challenges that confront Catholic health care today, it is important to know which civil law forms will assist in preserving the Church's ministry. The proper meshing of civil law and canon law thus provides a vehicle to strengthen the apostolate's work. The case studies presented here suggest several means of applying the principles in the new Code of Canon Law to three potentially problematic situations: the merger of a Catholic and non-Catholic hospital, the leasing of a Catholic hospital to an operating company, and the use of the multicorporate format. PMID:10274590

  8. Photorepair mutants of Arabidopsis

    International Nuclear Information System (INIS)

    UV radiation induces two major DNA damage products, the cyclobutane pyrimidine dimer (CPD) and, at a lower frequency, the pyrimidine (6-4) pyrimidinone dimer (6-4 product). Although Escherichia coli and Saccharomyces cerevisiae produce a CPD-specific photolyase that eliminates only this class of dimer, Arabidopsis thaliana, Drosophila melanogaster, Crotalus atrox, and Xenopus laevis have recently been shown to photoreactivate both CPDs and 6-4 products. We describe the isolation and characterization of two new classes of mutants of Arabidopsis, termed uvr2 and uvr3, that are defective in the photoreactivation of CPDs and 6-4 products, respectively. We demonstrate that the CPD photolyase mutation is genetically linked to a DNA sequence encoding a type II (metazoan) CPD photolyase. In addition, we are able to generate plants in which only CPDs or 6-4 products are photoreactivated in the nuclear genome by exposing these mutants to UV light and then allowing them to repair one or the other class of dimers. This provides us with a unique opportunity to study the biological consequences of each of these two major UV-induced photoproducts in an intact living system

  9. A parathyroid scintigraphy case study

    Energy Technology Data Exchange (ETDEWEB)

    O' Leary, Desiree [UCD School of Diagnostic Imaging, St Anthony' s Campus, Herbert Avenue, Dublin 4 (Ireland)]. E-mail: desiree.oleary@ucd.ie

    2005-05-01

    Background: There has been much debate concerning the most suitable protocol for parathyroid scintigraphy; the merits of various radiopharmaceuticals versus the correct imaging protocol to visualise both ectopic and anatomically placed adenomas against the various equipment choices have been debated. Aim: To demonstrate, through the use of a case study, the necessity of changing imaging protocols for parathyroid scintigraphy where a definitive imaging diagnosis is absent in the face of strong clinical suspicion. Method: Use is made of Tc99mMIBI, full field chest scintigraphy, a clearly defined imaging protocol and SPECT imaging to locate ectopic parathyroid tissue in a female patient with significant symptoms of parathyroid hyperfunction. Results: A single hyperfunctioning adenoma is located in the pre-carinal area of the mediastinum. Using a radioguided surgical technique the hyperfunctioning tissue is excised and confirmed by histopathology. Conclusion: Whilst a dramatic reduction in patient symptoms was not seen immediately in this patient, the symptoms of the illness have been subsiding since January 2003. This case study demonstrates the necessity of changing imaging protocols for parathyroid scintigraphy where a definitive imaging diagnosis is absent in the face of strong clinical suspicion.

  10. MADS on the move : a study on MADS domain protein function and movement during floral development in Arabidopsis thaliana

    NARCIS (Netherlands)

    Urbanus, S.L.

    2010-01-01

    In this thesis we investigated the behaviour of fluorescently-tagged MADS domain proteins during floral development in the model plant Arabidopsis thaliana, and explored the importance of intercellular transport via plasmodesmata for MADS domain transcription factor functioning. The MADS domain tran

  11. Arabidopsis thaliana DM2h (R8) within the Landsberg RPP1-like Resistance Locus Underlies Three Different Cases of EDS1-Conditioned Autoimmunity

    Science.gov (United States)

    Garcia, Ana V.; Wagner, Christine; Choudhury, Sayan R.; Wang, Yiming; James, Geo Velikkakam; Griebel, Thomas; Alcázar, Ruben; Tsuda, Kenichi; Schneeberger, Korbinian; Parker, Jane E.

    2016-01-01

    Plants have a large panel of nucleotide-binding/leucine rich repeat (NLR) immune receptors which monitor host interference by diverse pathogen molecules (effectors) and trigger disease resistance pathways. NLR receptor systems are necessarily under tight control to mitigate the trade-off between induced defenses and growth. Hence, mis-regulated NLRs often cause autoimmunity associated with stunting and, in severe cases, necrosis. Nucleocytoplasmic ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1) is indispensable for effector-triggered and autoimmune responses governed by a family of Toll-Interleukin1-Receptor-related NLR receptors (TNLs). EDS1 operates coincidently or immediately downstream of TNL activation to transcriptionally reprogram cells for defense. We show here that low levels of nuclear-enforced EDS1 are sufficient for pathogen resistance in Arabidopsis thaliana, without causing negative effects. Plants expressing higher nuclear EDS1 amounts have the genetic, phenotypic and transcriptional hallmarks of TNL autoimmunity. In a screen for genetic suppressors of nuclear EDS1 autoimmunity, we map multiple, independent mutations to one gene, DM2h, lying within the polymorphic DANGEROUS MIX2 cluster of TNL RPP1-like genes from A. thaliana accession Landsberg erecta (Ler). The DM2 locus is a known hotspot for deleterious epistatic interactions leading to immune-related incompatibilities between A. thaliana natural accessions. We find that DM2hLer underlies two further genetic incompatibilities involving the RPP1-likeLer locus and EDS1. We conclude that the DM2hLer TNL protein and nuclear EDS1 cooperate, directly or indirectly, to drive cells into an immune response at the expense of growth. A further conclusion is that regulating the available EDS1 nuclear pool is fundamental for maintaining homeostatic control of TNL immune pathways. PMID:27082651

  12. KAIZEN – A case study

    Directory of Open Access Journals (Sweden)

    Manjunath Shettar

    2015-05-01

    Full Text Available The ultimate objective of manufacturing industries is to increase productivity with high quality. At present, many manufacturing companies are facing problems such as high quality rejection, high inventories, high lead time, high costs of production, and inability to cope with customer orders. By implementing and practicing the lean production system many problems can be solved without employing high-tech and high-touch approaches but by involving people on the shop floor in Kaizen activities. Kaizen is one of the powerful tools of lean manufacturing. Kaizen refers to continuous improvement in performance, cost and quality. Kaizen ensures that manufacturing processes become leaner and fitter, but eliminate waste (problem where value is added. The main objective of this paper is to provide a background on kaizen, present an overview of kaizen concepts that are used to transform a company into a high performing lean enterprise. A case study of implementation of Kaizen‟s has been discussed.

  13. STS Case Study Development Support

    Science.gov (United States)

    Rosa de Jesus, Dan A.; Johnson, Grace K.

    2013-01-01

    The Shuttle Case Study Collection (SCSC) has been developed using lessons learned documented by NASA engineers, analysts, and contractors. The SCSC provides educators with a new tool to teach real-world engineering processes with the goal of providing unique educational materials that enhance critical thinking, decision-making and problem-solving skills. During this third phase of the project, responsibilities included: the revision of the Hyper Text Markup Language (HTML) source code to ensure all pages follow World Wide Web Consortium (W3C) standards, and the addition and edition of website content, including text, documents, and images. Basic HTML knowledge was required, as was basic knowledge of photo editing software, and training to learn how to use NASA's Content Management System for website design. The outcome of this project was its release to the public.

  14. Physiological and molecular basis of Azospirillum-Arabidopsis Interaction

    OpenAIRE

    Nazeer, Ahmed

    2012-01-01

    The present study was aimed at revealing the early signalling events during the interaction of the diazotrophic soil bacterium Azospirillum brasilense with its host plant Arabidopsis thaliana. Furthermore, taking advantage of the micro array technique, a comprehensive overview of Arabidopsis genes has been undertaken which are affected upon association with A. brasilense The characterization of the early responses of Arabidopsis plants upon inoculation with Azospirillum brasilense strain Sp7 ...

  15. Acyl chains of phospholipase D transphosphatidylation products in Arabidopsis cells: a study using multiple reaction monitoring mass spectrometry.

    Directory of Open Access Journals (Sweden)

    Dominique Rainteau

    Full Text Available BACKGROUND: Phospholipases D (PLD are major components of signalling pathways in plant responses to some stresses and hormones. The product of PLD activity is phosphatidic acid (PA. PAs with different acyl chains do not have the same protein targets, so to understand the signalling role of PLD it is essential to analyze the composition of its PA products in the presence and absence of an elicitor. METHODOLOGY/PRINCIPAL FINDINGS: Potential PLD substrates and products were studied in Arabidopsis thaliana suspension cells treated with or without the hormone salicylic acid (SA. As PA can be produced by enzymes other than PLD, we analyzed phosphatidylbutanol (PBut, which is specifically produced by PLD in the presence of n-butanol. The acyl chain compositions of PBut and the major glycerophospholipids were determined by multiple reaction monitoring (MRM mass spectrometry. PBut profiles of untreated cells or cells treated with SA show an over-representation of 160/18:2- and 16:0/18:3-species compared to those of phosphatidylcholine and phosphatidylethanolamine either from bulk lipid extracts or from purified membrane fractions. When microsomal PLDs were used in in vitro assays, the resulting PBut profile matched exactly that of the substrate provided. Therefore there is a mismatch between the acyl chain compositions of putative substrates and the in vivo products of PLDs that is unlikely to reflect any selectivity of PLDs for the acyl chains of substrates. CONCLUSIONS: MRM mass spectrometry is a reliable technique to analyze PLD products. Our results suggest that PLD action in response to SA is not due to the production of a stress-specific molecular species, but that the level of PLD products per se is important. The over-representation of 160/18:2- and 16:0/18:3-species in PLD products when compared to putative substrates might be related to a regulatory role of the heterogeneous distribution of glycerophospholipids in membrane sub-domains.

  16. Computational Study of the Binding Mechanism of Actin-Depolymerizing Factor 1 with Actin in Arabidopsis thaliana.

    Science.gov (United States)

    Du, Juan; Wang, Xue; Dong, Chun-Hai; Yang, Jian Ming; Yao, Xiao Jun

    2016-01-01

    Actin is a highly conserved protein. It plays important roles in cellular function and exists either in the monomeric (G-actin) or polymeric form (F-actin). Members of the actin-depolymerizing factor (ADF)/cofilin protein family bind to both G-actin and F-actin and play vital roles in actin dynamics by manipulating the rates of filament polymerization and depolymerization. It has been reported that the S6D and R98A/K100A mutants of actin-depolymerizing factor 1 (ADF1) in Arabidopsis thaliana decreased the binding affinity of ADF for the actin monomer. To investigate the binding mechanism and dynamic behavior of the ADF1-actin complex, we constructed a homology model of the AtADF1-actin complex based on the crystal structure of AtADF1 and the twinfilin C-terminal ADF-H domain in a complex with a mouse actin monomer. The model was then refined for subsequent molecular dynamics simulations. Increased binding energy of the mutated system was observed using the Molecular Mechanics Generalized Born Surface Area and Poisson-Boltzmann Surface Area (MM-GB/PBSA) methods. To determine the residues that make decisive contributions to the ADF1 actin-binding affinity, per-residue decomposition and computational alanine scanning analyses were performed, which provided more detailed information on the binding mechanism. Root-mean-square fluctuation and principal component analyses confirmed that the S6D and R98A/K100A mutants induced an increased conformational flexibility. The comprehensive molecular insight gained from this study is of great importance for understanding the binding mechanism of ADF1 and G-actin. PMID:27414648

  17. Numerical and structural chromosome aberrations in cauliflower (Brassica oleracea var. botrytis) and Arabidopsis thaliana

    NARCIS (Netherlands)

    Ji, X.

    2014-01-01

    Numerical and structural chromosome aberrations in cauliflower (Brassica oleracea var. botrytis) and Arabidopsis thaliana. I studied numerical and structural chromosome aberrations in cauliflower (Brassica oleracea var. botrytis) and Arabidopsis thaliana. The large genomic changes are important for

  18. Using Case Studies To Teach Science.

    Science.gov (United States)

    Gabel, Connie

    Using case studies in science instruction develops problem solving and enhances listening and cooperative learning skills. Unlike other disciplines such as law and medicine, the case study method is rarely used in science education to enrich the curriculum. This study investigates the use of content-based case studies as a means of developing…

  19. Catalog of NASA-Related Case Studies

    Data.gov (United States)

    National Aeronautics and Space Administration — The OCKO has developed over 50 case studies to enhance learning at workshops, training, retreats and conferences. Case studies make mission knowledge attractive and...

  20. Summary of case studies for cooperation mechanisms

    DEFF Research Database (Denmark)

    Longa, Francesco Dalla; Klinge Jacobsen, Henrik; Hansen, Lise-Lotte Pade; Tantareanu, Cristian; Caldes-Gomez, Natalia; Santamaria-Belda, Marta

    2012-01-01

    This document is a summary report highlighting the main aspect analyzed in the RES4LESS case studies. The document starts with an introductory chapter where the background that led to the selection of the case studies is outlined. In the following three chapters the case studies are presented, hi...

  1. Case Study: The Chemistry of Cocaine

    Science.gov (United States)

    Dewprashad, Brahmadeo

    2011-01-01

    This column provides original articles on innovations in case study teaching, assessment of the method, as well as case studies with teaching notes. This month's case study focuses on the chemistry of cocaine to teach a number of core concepts in organic chemistry. It also requires that students read and analyze an original research paper on…

  2. Concentrated photovoltaics, a case study

    Directory of Open Access Journals (Sweden)

    Antonini Piergiorgio

    2014-01-01

    Full Text Available Concentrated Photovoltaics (CPV, once a niche technology, has now reached the maturity and reliability for large scale power generation. Especially in regions where temperatures are very high, the use of high efficiency triple junction solar cells with concentrating optics allows stable energy yield. Thus CPV can be seen as complementary and not in concurrence with silicon photovoltaics. The state of the art, the advantages and limitations of this technology will be shown. Among the main advantages of CPV is the possibility of a much higher energy supply, when compared to silicon photovoltaics, both comparing CPV and silicon with same area or the same installed power. The use of recycled and recyclable materials allows a more environmentally friendly production. The possibility to couple CPV with desalination facilities, energy storage will be analysed. As an example a case study of a CPV installation in Northern Italy is discussed. Here the use of mature technologies, derived from automotive and lighting sectors resulted in a simple and efficient module.

  3. Concentrated photovoltaics, a case study

    Science.gov (United States)

    Antonini, Piergiorgio; Centro, Sandro; Golfetto, Stelvio; Saccà, Alessandro

    2014-12-01

    Concentrated Photovoltaics (CPV), once a niche technology, has now reached the maturity and reliability for large scale power generation. Especially in regions where temperatures are very high, the use of high efficiency triple junction solar cells with concentrating optics allows stable energy yield. Thus CPV can be seen as complementary and not in concurrence with silicon photovoltaics. The state of the art, the advantages and limitations of this technology will be shown. Among the main advantages of CPV is the possibility of a much higher energy supply, when compared to silicon photovoltaics, both comparing CPV and silicon with same area or the same installed power. The use of recycled and recyclable materials allows a more environmentally friendly production. The possibility to couple CPV with desalination facilities, energy storage will be analysed. As an example a case study of a CPV installation in Northern Italy is discussed. Here the use of mature technologies, derived from automotive and lighting sectors resulted in a simple and efficient module.

  4. Belowground neighbor perception in Arabidopsis thaliana studied by transcriptome analysis: roots of Hieracium pilosella cause biotic stress

    OpenAIRE

    Schmid, Christoph; Bauer, Sibylle; Müller, Benedikt; Bartelheimer, Maik

    2013-01-01

    Root-root interactions are much more sophisticated than previously thought, yet the mechanisms of belowground neighbor perception remain largely obscure. Genome-wide transcriptome analyses allow detailed insight into plant reactions to environmental cues. A root interaction trial was set up to explore both morphological and whole genome transcriptional responses in roots of Arabidopsis thaliana in the presence or absence of an inferior competitor, Hieracium pilosella. Neighbor perception was ...

  5. A molecular-genetic approach to studying source-sink interactions in Arabidopsis thalian. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Gibson, S. I.

    2000-06-01

    This is a final report describing the results of the research funded by the DOE Energy Biosciences Program grant entitled ''A Molecular-Genetic Approach to Studying Source-Sink Interactions in Arabidiopsis thaliana''.

  6. A HARD CHOICE (CASE STUDY)

    OpenAIRE

    KRAVCHENKO NATALIYA A.; KUZNETSOVA SVETLANA A.

    2014-01-01

    The case describes the problems of strategic choice: a small company successfully working in the engineering market (automation of technological processes) in the electric power industry has to make a decision on its further development in a changing external environment and increased competition. The case was carried out to be used in training programs of different levels within the courses “Strategic Management”, “Innovation Management”, “Strategic Analysis Methods”, “Change Management” whe...

  7. Arabidopsis thaliana—Aphid Interaction

    OpenAIRE

    Louis, Joe; Singh, Vijay,; Shah, Jyoti

    2012-01-01

    Aphids are important pests of plants that use their stylets to tap into the sieve elements to consume phloem sap. Besides the removal of photosynthates, aphid infestation also alters source-sink patterns. Most aphids also vector viral diseases. In this chapter, we will summarize on recent significant findings in plant-aphid interaction, and how studies involving Arabidopsis thaliana and Myzus persicae (Sülzer), more commonly known as the green peach aphid (GPA), are beginning to provide impor...

  8. Selenium Speciation in Arabidopsis Thaliana

    OpenAIRE

    Wang, Xiaoou

    2011-01-01

    Selenium has been proved as an essential micronutrient and is beneficial to animals and humans. It is a structural component of the important antioxidant enzyme, glutathione peroxidase, which catalyzes reactions to detoxify reactive oxygen species. However, the essentiality of Se in plants remains controversial and the protective role of Se in plants has rarely been investigated. In this study, Arabidopsis thaliana was grown in controlled environments having selenate or selenite enriched medi...

  9. Case Study Methodology and Homelessness Research

    OpenAIRE

    Jill Pable

    2013-01-01

    This paper describes the potential suitability of case study methodology for inquiry with the homeless population. It references a research study that uses case study research method to build theory. This study's topic is the lived experience of destitute individuals who reside in homeless shelters, and explores the homeless shelter built environment's potential influence on resident satisfaction and recovery. Case study methodology may be appropriate because it explores real-life contextual ...

  10. Five Misunderstandings About Case-Study Research

    DEFF Research Database (Denmark)

    Flyvbjerg, Bent

    2006-01-01

    one and concludes with the Kuhnian insight that a scientific discipline without a large number of thoroughly executed case studies is a discipline without systematic production of exemplars, and a discipline without exemplars is an ineffective one. Social science may be strengthened by the execution......This article examines five common misunderstandings about case-study research: (a) theoretical knowledge is more valuable than practical knowledge; (b) one cannot generalize from a single case, therefore, the single-case study cannot contribute to scientific development; (c) the case study is most...... useful for generating hypotheses, whereas other methods are more suitable for hypotheses testing and theory building; (d) the case study contains a bias toward verification; and (e) it is often difficult to summarize specific case studies. This article explains and corrects these misunderstandings one by...

  11. Five misunderstandings about case study research

    DEFF Research Database (Denmark)

    Flyvbjerg, Bent

    2004-01-01

    and concludes with the Kuhnian insight that a scientific discipline without a large number of thoroughly executed case studies is a discipline without systematic production of exemplars, and that a discipline without exemplars is an ineffective one. Social science may be strengthened by the execution......This article examines five common misunderstandings about case-study research: (1) Theoretical knowledge is more valuable than practical knowledge; (2) One cannot generalize from a single case, therefore the single case study cannot contribute to scientific development; (3) The case study is most...... useful for generating hypotheses, while other methods aremore suitable for hypotheses testing and theory building; (4) The case study contains a bias toward verification; and (5) It is often difficult to summarize specific case studies. The article explains and corrects these misunderstandings one by one...

  12. Five misunderstandings about Case-study Research

    DEFF Research Database (Denmark)

    Flyvbjerg, Bent

    and concludes with the Kuhnian insight that a scientific discipline without a large number of thoroughly executed case studies is a discipline without systematic production of exemplars, and that a discipline without  exemplars is an ineffective one. Social science may be strengthened by the execution......This article examines five common misunderstandings about case-study research: (1) Theoretical knowledge is more valuable than practical knowledge; (2) One cannot generalize from a single case, therefore the single case study cannot contribute to scientific development; (3) The case study is most...... useful for generating hypotheses, while other methods aremore suitable for hypotheses testing and theory building; (4) The case study contains a bias toward verification; and (5) It is often difficult to summarize specific case studies. The article explains and corrects these misunderstandings one by one...

  13. Engineering carpel-specific cold stress tolerance: a case study in Arabidopsis

    Science.gov (United States)

    Freezing temperatures during winter generally do not injure floral buds of horticulturally important crops. Entry into dormancy coupled with cold acclimation provides adequate protection unless the temperatures are exceptionally low. This measure of protection is lost in spring when the floral bud...

  14. Drive Electric Vermont Case Study

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Fred [Energetics Incorporated, Columbia, MD (United States); Roberts, Dave [Vermont Energy Investment Corporation (VEIC), Burlington, VT (United States); Francfort, Jim [Idaho National Lab. (INL), Idaho Falls, ID (United States); White, Sera [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-03-01

    Currently in the United States, the heavy majority of plug-in electric vehicle (PEV) sales have been in highly conducive, selected, metropolitan areas; opposed to more broad distribution across the country. The U.S. Department of Energy’s EV Everywhere Grand Challenge is looking carefully at the barriers and opportunities that exist to enable small and midsize communities to partake in the PEV market and benefit from the economic and environmental advantages of PEVs. In order to gain insight into these challenges and barriers, DOE selected a success story (i.e., Drive Electric Vermont) as the subject of this case study, as the state of Vermont is tied with Detroit, Michigan in having the highest percentage of 2014 (most recent complete data) PEV registrations for cold weather U.S. cities and has seen more than a sixfold increase in charging stations over the last three years. The overall objective of this case study was to use the lessons learned from Drive Electric Vermont to determine what activities are most effective at encouraging acquisitions of PEVs and deployment of charging infrastructure in small to midsize communities, prioritizing and sequencing their implementation, identifying robust means for extrapolation, and applying this understanding to other small to midsize communities across the nation. The Drive Electric Vermont Program was formed in 2012 with a goal of increasing the use of electrified transportation in Vermont through policy development, education and outreach, and infrastructure development. The Drive Electric Vermont Program can be broadly broken into four components: (1) strategic planning/leadership, (2) stakeholder/partnership development, (3) education and outreach, and (4) incentives. The early phases of the program focused heavily on strategic planning, and stakeholder and partnership development, followed by a transition to education and outreach activities, charging infrastructure development, and grant and incentive programs

  15. Roadmaster Roading Contractors Case Study

    Directory of Open Access Journals (Sweden)

    Hazel Taylor

    1999-01-01

    Full Text Available Systems analysis students seldom experience the practical difficulties of the initial investigation into a client’s requirements. They get little chance to practice the skills they need to investigate complex and confused problem situations, or to appreciate the wider organizational issues that can impact on a situation. This teaching case is designed to give students the opportunity to practice and apply investigation skills and to challenge them to consider the wider work environment when considering possible solutions to a problem situation. The case is conducted as a role-play, with students acting as systems analysts and teaching staff role-playing the clients. The students develop a report analyzing the client’s situation based on the issues that arise during the interviews. Feed-back sessions focus on discussing how well the students applied various interviewing strategies previously covered in lectures, and on the wider organizational problems that could impact proposed information system solutions.

  16. Associative Visual Agnosia: A Case Study

    OpenAIRE

    A. Charnallet; S. Carbonnel; David, D; O. Moreaud

    2008-01-01

    We report a case of massive associative visual agnosia. In the light of current theories of identification and semantic knowledge organization, a deficit involving both levels of structural description system and visual semantics must be assumed to explain the case. We suggest, in line with a previous case study [1], an alternative account in the framework of (non abstractive) episodic models of memory [4].

  17. Study on Case Teaching of Financial Management

    Science.gov (United States)

    Che, Zhenghong; Che, Zhengmei

    2011-01-01

    Case teaching is an efficient teaching method of management. It plays an important role to enhance the students' ability to practice the theory. However, case teaching of financial management has not achieved the expected results. The paper aims to study the importance, characteristics and corresponding methods of case teaching method of financial…

  18. Crystallization and preliminary X-ray diffraction study of a cell-wall invertase from Arabidopsis thaliana

    International Nuclear Information System (INIS)

    Crystals suitable for structural analysis have been prepared from a cell-wall invertase from A. thaliana. Cell-wall invertase 1 (AtcwINV1), a plant protein from Arabidopsis thaliana which is involved in the breakdown of sucrose, has been crystallized in two different crystal forms. Crystal form I grows in space group P31 or P32, whereas crystal form II grows in space group C2221. Data sets were collected for crystal forms I and II to resolution limits of 2.40 and 2.15 Å, respectively

  19. Academic Planning: Four Institutional Case Studies.

    Science.gov (United States)

    Kieft, Raymond N.

    As part of a project studying intrainstitutional planning, management, and evaluation, four case studies were undertaken in 1976 of academic planning at Villa Maria College, Kansas City Metropolitan Community College District, West Virginia University, and Western Washington University. The case studies were part of an ongoing project, the…

  20. The Danish National Case Study Report

    DEFF Research Database (Denmark)

    Brodersen, Søsser; Jørgensen, Michael Søgaard

    Three case studies from Danish science shops within the environmental field are analysed with respect to societal background, interaction between the involved actors and the societal impact of the co-operation. The report is one of the seven national case study reports from the EU-financed INTERA......Three case studies from Danish science shops within the environmental field are analysed with respect to societal background, interaction between the involved actors and the societal impact of the co-operation. The report is one of the seven national case study reports from the EU......-financed INTERACTS project....

  1. Co-localisation studies of Arabidopsis SR splicing factors reveal different types of speckles in plant cell nuclei

    International Nuclear Information System (INIS)

    SR proteins are multidomain splicing factors which are important for spliceosome assembly and for regulation of alternative splicing. In mammalian nuclei these proteins localise to speckles from where they are recruited to transcription sites. By using fluorescent protein fusion technology and different experimental approaches it has been shown that Arabidopsis SR proteins, in addition to diffuse nucleoplasmic staining, localise into an irregular nucleoplasmic network resembling speckles in mammalian cells. As Arabidopsis SR proteins fall into seven conserved sub-families we investigated co-localisation of members of the different sub-families in transiently transformed tobacco protoplast. Here we demonstrate the new finding that members of different SR protein sub-families localise into distinct populations of nuclear speckles with no, partial or complete co-localisation. This is particularly interesting as we also show that these proteins do interact in a yeast two-hybrid assay as well as in pull-down and in co-immunopreciptiation assays. Our data raise the interesting possibility that SR proteins are partitioned into distinct populations of nuclear speckles to allow a more specific recruitment to the transcription/pre-mRNA processing sites of particular genes depending on cell type and developmental stage

  2. Giant adrenal cyst: case study.

    Science.gov (United States)

    Poiana, Catalina; Carsote, Mara; Chirita, Corina; Terzea, Dana; Paun, S; Beuran, M

    2010-01-01

    One of the rarest situations regarding an adrenal incidentaloma is an adrenal cyst. We present the case of a 61-year-old male patient diagnosed with peritonitis. During surgery, a right adrenal tumor of 2 cm is discovered. The patient was referred to endocrinology. 6 months later the diameter of the tumor is 7 times bigger than the initial stage. It has no secretory phenotype, except for the small increase of serum aldosterone and the 24-h 17-ketosteroids. Open right adrenalectomy is performed and a cyst of 15 cm is removed. The evolution after surgery is good. The pathological exam reveals an adrenal cyst with calcifications and osteoid metaplasia. The immunohistochemistry showed a positive reaction for CD34 and ACT in the vessels and VIM in the stroma. The adrenal cysts are not frequent and represent a challenge regarding the preoperative diagnostic and surgical procedure of resection. The pathological exam highlights the major aspects. PMID:20945822

  3. Mining the active proteome of Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Renier A. L. Van Der Hoorn

    2011-11-01

    Full Text Available Assigning functions to the >30.000 proteins encoded by the Arabidopsis genome is a challenging task of the Arabidopsis Functional Genomics Network. Although genome-wide technologies like proteomics and transcriptomics have generated a wealth of information that significantly accelerated gene annotation, protein activities are poorly predicted by transcript or protein levels as protein activities are post-translationally regulated. To directly display protein activities in Arabidopsis proteomes, we developed and applied Activity-based Protein Profiling (ABPP. ABPP is based on the use of small molecule probes that react with the catalytic residues of distinct protein classes in an activity-dependent manner. Labeled proteins are separated and detected from proteins gels and purified and identified by mass spectrometry. Using probes of six different chemotypes we have displayed of activities of 76 Arabidopsis proteins. These proteins represent over ten different protein classes that contain over 250 Arabidopsis proteins, including cysteine- serine- and metallo-proteases, lipases, acyltransferases, and the proteasome. We have developed methods for identification of in vivo labeled proteins using click-chemistry and for in vivo imaging with fluorescent probes. In vivo labeling has revealed novel protein activities and unexpected subcellular activities of the proteasome. Labeling of extracts displayed several differential activities e.g. of the proteasome during immune response and methylesterases during infection. These studies illustrate the power of ABPP to display the functional proteome and testify to a successful interdisciplinary collaboration involving chemical biology, organic chemistry and proteomics.

  4. A case study of embarrassment.

    Science.gov (United States)

    Dann, O T

    1977-01-01

    The psychoanalytic references to embarrassment are reviewed. Embarrassment, in the literature, is seen largely as an affect involving exhibitionistic and scopophilic conflicts and defenses against these. A case in which embarrassment was prominent is discussed. Embarrassment in the patient was an ego response which implied an external object for its manifestation. It involved exhibitionistic and scopophilic conflicts and projective defenses, but also operated in ego-gratifying and adaptive ways. Her embarrassment was understood through the analysis of an initial embarrassing dream of nakedness and other dreams and associated material as the defensive out-grouth of repeated exposures to the primal scene. Embarrassment was a resistance to remembering in the analysis, and the primal-scene experiences were partially reconstructed. The analytic situation was, in many ways, a symbolic re-creation of the primal scene, including the patient's response of embarrassment. The development of embarrassment in the patient's childhood was furthered and confirmed by its being an identification with the attitudes of both parents. Finally, some reflections on embarrassment and shame in its various forms are set forth. PMID:560404

  5. Five case studies of multifamily weatherization programs

    Energy Technology Data Exchange (ETDEWEB)

    Kinney, L; Wilson, T.; Lewis, G. [Synertech Systems Corp. (United States); MacDonald, M. [Oak Ridge National Lab., TN (United States)

    1997-12-31

    The multifamily case studies that are the subject of this report were conducted to provide a better understanding of the approach taken by program operators in weatherizing large buildings. Because of significant variations in building construction and energy systems across the country, five states were selected based on their high level of multifamily weatherization. This report summarizes findings from case studies conducted by multifamily weatherization operations in five cities. The case studies were conducted between January and November 1994. Each of the case studies involved extensive interviews with the staff of weatherization subgrantees conducting multifamily weatherization, the inspection of 4 to 12 buildings weatherized between 1991 and 1993, and the analysis of savings and costs. The case studies focused on innovative techniques which appear to work well.

  6. Theoretical pluralism in psychoanalytic case studies

    Science.gov (United States)

    Willemsen, Jochem; Cornelis, Shana; Geerardyn, Filip M.; Desmet, Mattias; Meganck, Reitske; Inslegers, Ruth; Cauwe, Joachim M. B. D.

    2015-01-01

    The aim of this study is to provide an overview of the scientific activity of different psychoanalytic schools of thought in terms of the content and production of case studies published on ISI Web of Knowledge. Between March 2013 and November 2013, we contacted all case study authors included in the online archive of psychoanalytic and psychodynamic case studies (www.singlecasearchive.com) to inquire about their psychoanalytic orientation during their work with the patient. The response rate for this study was 45%. It appears that the two oldest psychoanalytic schools, Object-relations psychoanalysis and Ego psychology or “Classical psychoanalysis” dominate the literature of published case studies. However, most authors stated that they feel attached to two or more psychoanalytic schools of thought. This confirms that the theoretical pluralism in psychoanalysis stretches to the field of single case studies. The single case studies of each psychoanalytic school are described separately in terms of methodology, patient, therapist, or treatment features. We conclude that published case studies features are fairly similar across different psychoanalytic schools. The results of this study are not representative of all psychoanalytic schools, as some do not publish their work in ISI ranked journals. PMID:26483725

  7. Rebranding: a Case Study Approach

    OpenAIRE

    Size, Maria, (Thesis)

    2005-01-01

    The primary objective of this study is to explore how and why companies implement rebranding campaigns. The study stemmed from a realisation by the author that the area of rebranding is very much under-researched academically although anecdotal evidence indicates and increase in the occurrence of the phenomenon in recent years. Therefore the purpose of this research is to add to the insufficient body of literature on rebranding through exploring it from a corporate perspective. The two chapte...

  8. Outage management: A case study

    International Nuclear Information System (INIS)

    Outage management issues identified from a field study conducted at a two-unit commercial pressurized water reactor (PWR), when one unit was in a refueling outage and the other unit was at full power operation, are the focus of this paper. The study was conduced as part of the US Nuclear Regulatory Commission's (NRC) organizational factors research program, and therefore the issues to be addressed are from an organizational perspective. Topics discussed refer to areas identified by the NRC as critical for safety during shutdown operations, including outage planning and control, personnel stress, and improvements in training and procedures. Specifically, issues in communication, management attention, involvement and oversight, administrative processes, organizational culture, and human resources relevant to each of the areas are highlighted by example from field data collection. Insights regarding future guidance in these areas are presented based upon additional data collection subsequent to the original study

  9. Outage management: A case study

    Energy Technology Data Exchange (ETDEWEB)

    Haber, S.B.; Barriere, M.T. (Brookhaven National Lab., Upton, NY (United States)); Roberts, K.H. (California Univ., Berkeley, CA (United States). Walter A. Haas School of Business)

    1992-01-01

    Outage management issues identified from a field study conducted at a two-unit commercial pressurized water reactor (PWR), when one unit was in a refueling outage and the other unit was at full power operation, are the focus of this paper. The study was conduced as part of the US Nuclear Regulatory Commission's (NRC) organizational factors research program, and therefore the issues to be addressed are from an organizational perspective. Topics discussed refer to areas identified by the NRC as critical for safety during shutdown operations, including outage planning and control, personnel stress, and improvements in training and procedures. Specifically, issues in communication, management attention, involvement and oversight, administrative processes, organizational culture, and human resources relevant to each of the areas are highlighted by example from field data collection. Insights regarding future guidance in these areas are presented based upon additional data collection subsequent to the original study.

  10. Outage management: A case study

    Energy Technology Data Exchange (ETDEWEB)

    Haber, S.B.; Barriere, M.T. [Brookhaven National Lab., Upton, NY (United States); Roberts, K.H. [California Univ., Berkeley, CA (United States). Walter A. Haas School of Business

    1992-09-01

    Outage management issues identified from a field study conducted at a two-unit commercial pressurized water reactor (PWR), when one unit was in a refueling outage and the other unit was at full power operation, are the focus of this paper. The study was conduced as part of the US Nuclear Regulatory Commission`s (NRC) organizational factors research program, and therefore the issues to be addressed are from an organizational perspective. Topics discussed refer to areas identified by the NRC as critical for safety during shutdown operations, including outage planning and control, personnel stress, and improvements in training and procedures. Specifically, issues in communication, management attention, involvement and oversight, administrative processes, organizational culture, and human resources relevant to each of the areas are highlighted by example from field data collection. Insights regarding future guidance in these areas are presented based upon additional data collection subsequent to the original study.

  11. Case Study Methodology and Homelessness Research

    Directory of Open Access Journals (Sweden)

    Jill Pable

    2013-10-01

    Full Text Available This paper describes the potential suitability of case study methodology for inquiry with the homeless population. It references a research study that uses case study research method to build theory. This study's topic is the lived experience of destitute individuals who reside in homeless shelters, and explores the homeless shelter built environment's potential influence on resident satisfaction and recovery. Case study methodology may be appropriate because it explores real-life contextual issues that characterize homelessness and can also accommodate the wide range of homeless person demographics that make this group difficult to study in a generalized fashion. Further, case study method accommodates the need within research in this area to understand individualized treatments as a potential solution for homelessness.

  12. A Case Study of Engineering Ethics

    Science.gov (United States)

    Shimizu, Kazuo

    In Engineering Ethics Class at Shizuoka University, the Code of Ethics and Cases for Electrical Engineers by IEEJ Ethics committee is used to promote for high education effect to correspond large number of students (140students). In this paper, a case study in the class, and survey results for ethics value of students are presented. In addition, some comments for role playing act on the case of virtual experiences by students are described.

  13. Environmental contracting: a case study

    OpenAIRE

    Kubiak, Joseph C.

    1994-01-01

    Approved for public release, distribution unlimited The end of cold war levels of defense expenditures has promoted the reduction in the number of defense-related companies, creating potential monopolistic economic scenarios for defense procurement. This thesis studies one methodology to deal with these scenarios, based on the Baron-Myerson monopolist regulation mechanisms. The Baron-Myerson mechanism provides a tool to regulate monopolists when their costs are unknown or cannot be measure...

  14. Marketing-Indonesia case study

    OpenAIRE

    Kurniawan, Iwan; Roshetko, James M.

    2007-01-01

    The purpose of research are (1) to identify the potential VAF species or products for Nanggung Farmers; (2) identify market channels & marketing problems; (3) enhances farmers' understanding of market mechanism; and (4) identify opportunities to improve the quantity & quality of VAF. The study was conducted on Sept-Oct 2006. Data and information are collected through Focus Group Discussion (FGD) in each village that attended both men and women. LTRA-5 (Agroforestry and Sustainable Vegetabl...

  15. Recombinant formate dehydrogenase from Arabidopsis thaliana: Preparation, crystal growth in microgravity, and preliminary X-ray diffraction study

    International Nuclear Information System (INIS)

    Crystals of high-purity recombinant NAD+-dependent formate dehydrogenase from the higher plant Arabidopsis thaliana (AraFDH) were grown in microgravity in the Modul'-1 protein crystallization apparatus on the International Space Station. The space-grown crystals have larger sizes than those grown on Earth. X-ray diffraction data suitable for determining the three-dimensional structure were collected from the space-grown crystals to a resolution of 1.22 A using an X-ray synchrotron source. The crystals belong to sp. gr. P43212; the unit-cell parameters are a = b = 107.865 A, c = 71.180 A, α = β = γ = 90 deg.

  16. Linguistic Overgeneralization: A Case Study

    Directory of Open Access Journals (Sweden)

    Wasan Nazar Al-Baldawi

    2011-08-01

    Full Text Available The current study described a single child’s language acquisition. The importance of this study resided in the circumstances and the environment in which the child lived. He came from a family in which the parents were from different countries and cultures; spoke different Arabic dialects and who lived in a country in which English is spoken. The child was in his critical period of language acquisition. He seemed to have established a unique way of communicating with people surrounding him to cope with all the linguistic varieties around him. The study showed that the child had semantic, syntactic and morphological overgeneralized structures. The data and results showed that overgeneralization and language acquisition were primarily an innate faculty of the human mind and that imitation did played a primary role in language acquisition.It showed, nevertheless, that imitation and behaviorist approaches could not fully account for language acquisition nor did the generative approach. The results went in favor of an Emergentist approach of language acquisition where both innateness and imitations were crucial constituents of children’s acquisition of linguistic forms.

  17. Case Study: A Strategic Research Methodology

    Directory of Open Access Journals (Sweden)

    Khairul B.M. Noor

    2008-01-01

    Full Text Available This research reviews the literature on case study as a strategic qualitative research methodology. Although case studies have been criticised by some authors as lacking scientific rigour and do not address generalizability, this research, however, reiterated its appropriateness when dealing with a process or a complex real-life activities in great-depth. Case study has been commonly used in social science fields like sociology, industrial relations and anthropology eventhough generally was considered an underutilized strategy. Hence, this research explained the general concept of a case study, strengths and weaknesses of using this method knowing that theoretically case is exciting and data rich. Based on a study of four organizations and the researcher’s own experience, this article described matters on how case study was undertaken, gaining excess to those organizations and the systematic process of data collection and triangulation (multiple techniques. It was noted that combining multiple techniques for elicitng data in case study research actually strengthens and confirmed results.

  18. Brick handling: a case study.

    Science.gov (United States)

    Webb, R D; Handyside, J

    1982-09-01

    A small change in brick dimensions resulted in an increase in the perceived work-load of men loading and unloading pallets of bricks by hand. A laboratory study indicated that the change in brick dimensions required changes in grip pattern in order to unload bricks at the same rate, moving the same number at a time. These changed grip patterns resulted in increased upper body movement, increased chest-muscle activity and higher heart rates. These differences were reflected in higher subjective ratings of fatigue. PMID:15676442

  19. Ownership and Control Structures: A Case Study

    OpenAIRE

    Apostolov, Mico

    2015-01-01

    This is a study on separation of ownership and control in Southeast Europe, and in particular it is a case study of Macedonia. For structured analysis of this case study we use the World Bank Microdata Library, specifically the Enterprise Surveys which contains firm-level data of a representative sample of economies private sectors. What we are interested in are the ties of ownership and control and whether such linkages contribute to the development of domestic firms and the overall ec...

  20. Case studies of steel structure failures

    Directory of Open Access Journals (Sweden)

    P. Bernasovský

    2010-01-01

    Full Text Available The contribution deals with some case studies of steel structure failures, which happened in Slovakia a few years ago. Features of cracking are illustrated on real cases of breakdowns in the transmission gas pipelines, at the cement works and in the petrochemical indus-try. All failures were caused by an incorrect technical approach. Possible remedial measures are proposed.

  1. Case Studies of Environmental Risks to Children.

    Science.gov (United States)

    Goldman, Lynn R.

    1995-01-01

    Presents case studies on children's exposure to pesticides, including risks through the use of the insecticide aldicarb on bananas, the home use of diazinon, and the use of interior house paint containing mercury. These cases illustrate how regulatory agencies, parents, health-care providers, and others who come into contact with children have…

  2. Abbreviated Case Studies in Organizational Communication

    Science.gov (United States)

    Wanguri, Deloris McGee

    2005-01-01

    The cases contained within organizational communication texts are generally two to three pages, often followed by questions. These case studies are certainly useful. They generally describe events in the present, provide some type of organizational context, include first-hand data, include a record of what people say and think, develop a…

  3. Case study on printed matter

    DEFF Research Database (Denmark)

    global warming, acidification and nutrification. The studies focus on energy consumption including the emissions and impact categories related to energy. The chemical-related impact categories comprising ecotoxicity and human toxicity are not included at all or only to a limited degree. In this paper we...... European/global ones are used for sensitivity analysis. The weighting factors for the impact categories are based on political reduction targets. Conlusion  The distribution of potential environmental impacts along the life cycle of a generic printed matter produced on a model sheet feed offset printing...... distribution of potential environmental impacts and consumption of resources along the life cycle of a generic printed matter produced on a model sheet feed offset printing industry in Europe. Main activities at all stages in the life cycle are covered. However special focus is on the production stage but...

  4. A network security case study

    International Nuclear Information System (INIS)

    This paper reports on a study to validate the Graphical Network Representation (GRPHREP) model which is being conducted on the Los Alamos National Laboratory Integrated Computer Network (ICN). The GRPHREP model is a software system application based on graph theory and object-oriented programming methodologies. It codified the Department of Energy (DOE) Order 5637.1, which is concerned with classified computer secret policy, restrictions, and requirements. The Los Alamos ICN is required to control access to and support large-scale scientific and administrative computing. Thus, large-scale scientific and administrative computing. Thus we felt that this large, complex, and dynamic network would provide a good test for the graphical and functional capabilities of the model. Furthermore, the ICN is composed of multiple partitions that reflect the sensitivity and classification of the computation (data) and designate the required clearance level for the user

  5. Mining Product Data Models: A Case Study

    OpenAIRE

    Cristina-Claudia DOLEAN

    2014-01-01

    This paper presents two case studies used to prove the validity of some data-flow mining algorithms. We proposed the data-flow mining algorithms because most part of mining algorithms focuses on the control-flow perspective. First case study uses event logs generated by an ERP system (Navision) after we set several trackers on the data elements needed in the process analyzed; while the second case study uses the event logs generated by YAWL system. We offered a general solution of data-flow m...

  6. Case study in professionally-oriented training

    Directory of Open Access Journals (Sweden)

    Valitov Shamil M.

    2016-01-01

    Full Text Available Modern educational technologies are based on competence approach and focus on the future professional activity. Case study is one of the most significant technologies in modern higher education. The basic concepts used in the case study method are a “situation” and an “analysis”, as well as their derivative - “analysis of the situation”. The case study method of is one of the best tools for gaining experience, as it investigates practical situations that occur in managerial job. It combines theoretical knowledge with the analysis of the actual practical experience in accordance with a major. Doing case studies students read the description of the situation and offer divergent projects of managerial decisions that could be used by real managers dealing with the problem posed by the case study author. Answers to the questions posed in the case description are not given, as a rule, since the main purpose in the case analysis is to organize a discussion in the classroom or provoke speculations of those who do the self-study.

  7. Antiphospholipid syndrome: A case study

    International Nuclear Information System (INIS)

    Full text: A forty-two-year-old male presented to the Royal Adelaide Hospital with symptoms of increasing shortness of breath, swelling in both ankles, petechial rash and blood in his sputum. Initial investigations showed cardiomegaly, right ventricular hypertrophy, patchy lung infiltrates, a platelet count of 1500 and a clotting time of 60 seconds. A V/Q scan indicated a high probability of pulmonary embolism. Further investigations showed that the patient was positive for lupus anticoagulant and cardiolipin antibodies. A diagnosis of primary antiphospholipid syndrome was made. The patient''s high risk of strokes and hemorrhaging prompted investigation by a 99mTc-HMPAO brain scan. Further V/Q scans were performed to follow up the initial finding of multiple pulmonary embolism and a R-L shunt study was performed to investigate a left subclavian murmur. The patient was admitted for four weeks and began treatment which included cyclaphosphamide, corticosteroids and plasmaphoresis and was discharged when stable. Over the next six months he was re admitted three times for relapse of antiphospholipid syndrome. On his fourth admission he collapsed and died five hours after admission. Cause of death was due to cardiac arrhythmia secondary to severe right ventricular hypertrophy and dilation. The effects of antiphospholipid syndrome was believed to be responsible for this outcome

  8. Antiphospholipid syndrome: A case study

    Energy Technology Data Exchange (ETDEWEB)

    Davies, T. [Royal Adelaide Hospital, Adelaide, SA (Australia). Department of Nuclear Medicine

    1998-03-01

    Full text: A forty-two-year-old male presented to the Royal Adelaide Hospital with symptoms of increasing shortness of breath, swelling in both ankles, petechial rash and blood in his sputum. Initial investigations showed cardiomegaly, right ventricular hypertrophy, patchy lung infiltrates, a platelet count of 1500 and a clotting time of 60 seconds. A V/Q scan indicated a high probability of pulmonary embolism. Further investigations showed that the patient was positive for lupus anticoagulant and cardiolipin antibodies. A diagnosis of primary antiphospholipid syndrome was made. The patient``s high risk of strokes and hemorrhaging prompted investigation by a {sup 99}mTc-HMPAO brain scan. Further V/Q scans were performed to follow up the initial finding of multiple pulmonary embolism and a R-L shunt study was performed to investigate a left subclavian murmur. The patient was admitted for four weeks and began treatment which included cyclaphosphamide, corticosteroids and plasmaphoresis and was discharged when stable. Over the next six months he was re admitted three times for relapse of antiphospholipid syndrome. On his fourth admission he collapsed and died five hours after admission. Cause of death was due to cardiac arrhythmia secondary to severe right ventricular hypertrophy and dilation. The effects of antiphospholipid syndrome was believed to be responsible for this outcome.

  9. Multidimensional solid-state NMR studies of the structure and dynamics of pectic polysaccharides in uniformly 13C-labeled Arabidopsis primary cell walls

    Energy Technology Data Exchange (ETDEWEB)

    Dick-Perez, Marilu; Wang, Tuo; Salazar, Andre; Zabotina, Olga A.; Hong, Mei

    2012-07-08

    Plant cell wall (CW) polysaccharides are responsible for the mechanical strength and growth of plant cells; however, the high-resolution structure and dynamics of the CW polysaccharides are still poorly understood because of the insoluble nature of these molecules. Here, we use 2D and 3D magic-angle-spinning (MAS) solid-state NMR (SSNMR) to investigate the structural role of pectins in the plant CW. Intact and partially depectinated primary CWs of Arabidopsis thaliana were uniformly labeled with 13C and their NMR spectra were compared. Recent 13C resonance assignment of the major polysaccharides in Arabidopsis thaliana CWs allowed us to determine the effects of depectination on the intermolecular packing and dynamics of the remaining wall polysaccharides. 2D and 3D correlation spectra show the suppression of pectin signals, confirming partial pectin removal by chelating agents and sodium carbonate. Importantly, higher cross peaks are observed in 2D and 3D 13C spectra of the depectinated CW, suggesting higher rigidity and denser packing of the remaining wall polysaccharides compared with the intact CW. 13C spin–lattice relaxation times and 1H rotating-frame spin–lattice relaxation times indicate that the polysaccharides are more rigid on both the nanosecond and microsecond timescales in the depectinated CW. Taken together, these results indicate that pectic polysaccharides are highly dynamic and endow the polysaccharide network of the primary CW with mobility and flexibility, which may be important for pectin functions. This study demonstrates the capability of multidimensional SSNMR to determine the intermolecular interactions and dynamic structures of complex plant materials under near-native conditions. Copyright © 2012 John Wiley & Sons, Ltd.

  10. Towards More Case Study Research in Entrepreneurship

    Directory of Open Access Journals (Sweden)

    Tom Duxbury

    2012-03-01

    Full Text Available Entrepreneurship as an emerging discipline has made good strides, but according to some, has fallen short of bringing its theory and literature up to the standards of others in the management sciences. Rich with the descriptive detail needed for insightful theory building in entrepreneurship, scholars have called for more case study research, particularly those incorporating non-retrospective and longitudinal observations. At the same time however, it has become rare to find such research published in A-level journals dedicated to entrepreneurship. A survey presented here of major entrepreneurship journals over the past six years revealed a publication rate of only 3% using the case study method. This presents a major impediment for developing fresh research in this field based upon the study of real cases. The author explores how the case study method has been applied to entrepreneurship research and provides recommendations for improved publication rates.

  11. BTS Case Study: The Galloway Family Home

    International Nuclear Information System (INIS)

    Case study of an energy-efficient Habitat for Humanity house that uses 30% less energy than conventional residential construction. The project was part of the Jimmy Carter Work Project in rural Appalachia in 1997

  12. Educational Potential of Case-Study Technology

    OpenAIRE

    Fedorinova, Zoya Vladimirovna; Vorobyeva, Viktoriya Vladimirovna; Malyanova, Marina

    2015-01-01

    This article presents the results of phenomenological and typological analysis of case-study technology educational potential. The definition “educational potential of case-study technology” is given, the main characteristics of which are changed in communication and collaborative activity quality, appearance of educational initiatives, change of participants’ position in learning process, formation of “collective subject” in collaborative activity, increase of learning (subject) results. Dep...

  13. SYNONYMS IN ACTION: A CASE STUDY

    OpenAIRE

    Rebecca Clift

    2003-01-01

    This paper discusses what the methods of conversation analysis (CA) might have to offer the study of linguistic synonymy. It takes as a case study two items commonly held to be synonyms -'actually' and 'in fact'- and shows considerable differences between the two in their interactional implementation: they are implicated in the prosecution of differing courses of action. Such cases argue that it is analytically more profitable to consider what a lexical item does in the context of talk than w...

  14. TOP-10 DATA MINING CASE STUDIES

    OpenAIRE

    GABOR MELLI; XINDONG WU; PAUL BEINAT; FRANCESCO BONCHI; LONGBING CAO; RONG DUAN; CHRISTOS FALOUTSOS; RAYID GHANI; BRENDAN KITTS; BART GOETHALS; GEOFF MCLACHLAN; JIAN PEI; ASHOK SRIVASTAVA; OSMAR ZAÏANE

    2012-01-01

    We report on the panel discussion held at the ICDM'10 conference on the top 10 data mining case studies in order to provide a snapshot of where and how data mining techniques have made significant real-world impact. The tasks covered by 10 case studies range from the detection of anomalies such as cancer, fraud, and system failures to the optimization of organizational operations, and include the automated extraction of information from unstructured sources. From the 10 cases we find that sup...

  15. Predicting Students Drop Out: A Case Study

    Science.gov (United States)

    Dekker, Gerben W.; Pechenizkiy, Mykola; Vleeshouwers, Jan M.

    2009-01-01

    The monitoring and support of university freshmen is considered very important at many educational institutions. In this paper we describe the results of the educational data mining case study aimed at predicting the Electrical Engineering (EE) students drop out after the first semester of their studies or even before they enter the study program…

  16. Kinome profiling of Arabidopsis using arrays of kinase consensus substrates

    Directory of Open Access Journals (Sweden)

    Pieterse Corné MJ

    2007-02-01

    Full Text Available Abstract Background Kinome profiling aims at the parallel analysis of kinase activities in a cell. Novel developed arrays containing consensus substrates for kinases are used to assess those kinase activities. The arrays described in this paper were already used to determine kinase activities in mammalian systems, but since substrates from many organisms are present we decided to test these arrays for the determination of kinase activities in the model plant species Arabidopsis thaliana. Results Kinome profiling using Arabidopsis cell extracts resulted in the labelling of many consensus peptides by kinases from the plant, indicating the usefulness of this kinome profiling tool for plants. Method development showed that fresh and frozen plant material could be used to make cell lysates containing active kinases. Dilution of the plant extract increased the signal to noise ratio and non-radioactive ATP enhances full development of spot intensities. Upon infection of Arabidopsis with an avirulent strain of the bacterial pathogen Pseudomonas syringae pv. tomato, we could detect differential kinase activities by measuring phosphorylation of consensus peptides. Conclusion We show that kinome profiling on arrays with consensus substrates can be used to monitor kinase activities in plants. In a case study we show that upon infection with avirulent P. syringae differential kinase activities can be found. The PepChip can for example be used to purify (unknown kinases that play a role in P. syringae infection. This paper shows that kinome profiling using arrays of consensus peptides is a valuable new tool to study signal-transduction in plants. It complements the available methods for genomics and proteomics research.

  17. Induction and characterization of Arabidopsis mutants by Ion beam

    International Nuclear Information System (INIS)

    This study was conducted to search the proper conditions and times for irradiating proton beam to seeds generally used for induction of mutant. Arabidopsis as model plants has good characters that is a short generation time, producing a lot of seeds, sequenced genome, developed maker. This points were the best materials for plant breeding for this study. The data of inducing mutants of Arabidopsis is used to be applicate to crops have more longer generation that is the final goals of this study. The goals of this project were to inducing and characterizing arabidopsis mutants by the proton ion beam and γ-ray. As well as, the purpose of this study was securing more than 10 lines of arabidopsis mutants in this project and also to know the changed DNA structure of the mutants using the basic data for applying to the more study

  18. The study on space-flight induced DNA damage in Arabidopsis thaliana and the protective effect of hydrogen

    Science.gov (United States)

    Sun, Qiao; Liu, Min; Zhao, Hui

    2016-07-01

    Ionizing radiation (IR) is a known mutagen responsible for causing DNA strand breaks in all living organisms. Strand breaks thus created can be repaired by different mechanisms, including homologous recombination (HR), one of the key mechanisms maintaining genome stability. Here, we used previously generated Arabidopsis thaliana, transgenic for homologous recombination reporter system, in which homologous recombination frequency(HRF) was used as mutagenic end points. Based on the system, effect of DNA damage by space-flight during the Shenzhou-9 mission was investigated and the results showed that 13 days space-flight exposure of seedlings induced a significant increase in HRF compared with its ground-base three-dimensional clinostat controls and ground 1g controls. We also observed three-dimensional clinostat induced a significant increase in HRF compared with ground 1g controls. Molecular hydrogen (H2) has antioxidant activities by selectively reducing hydroxylradical ( •OH) and peroxynitrite(ONOO-), so we investigated the effect of hydrogen on IR-induced HRF. Treatment with hydrogen-rich water dramatically reduced the HR frequency induced by exposure of seedlings to 0 to 80 Gy 60Co radiation , suggesting that hydrogen represents a potentially novel preventative strategy for radiation-induced DNA damage in plants.

  19. Gigantic Suprapubic Lymphedema: A Case Study.

    Science.gov (United States)

    Tanhaeivash, Roozbeh; Franiel, Tobias; Grimm, Marc-Oliver; Horstmann, Marcus

    2016-08-01

    We present the first case study of idiopathic gigantic suprapubic lymphedema and buried penis treated with puboscrotal reconstruction in a patient with initial extreme obesity after an extensive weight reduction (120 kg). Massive localized lymphedema of the suprapubic region should be differentiated from the scrotal type. Severe lymphedema could not resolve on its own and weight reduction does not seem to be helpful in such cases. PMID:27574599

  20. Management by Values: A Case Study

    OpenAIRE

    Liu, Zhen

    2012-01-01

    The intention of this paper is to conclude the management approach by the case study of Chinese enterprise. There are a lot of management approaches in practice, one of the most influential and famous one is management by objective which is invented by the father of modern management discipline Peter F Drucker, he observed the case of American most successful enterprise such as GM and then concluded and created the relevant meaningful management tools, in effect, such valuable manage...

  1. Clean Cities Case Study: Barwood Cab Fleet Study Summary

    International Nuclear Information System (INIS)

    Barwood Cab Fleet Study Summary is the second in a new series called''Alternative Fuel Information Case Studies,'' designed to present real-world experiences with alternative fuels to fleet managers and other industry stakeholders

  2. Social Studies Project Evaluation: Case Study and Recommendations.

    Science.gov (United States)

    Napier, John

    1982-01-01

    Describes the development and application of a model for social studies program evaluations. A case study showing how the model's three-step process was used to evaluate the Improving Citizenship Education Project in Fulton County, Georgia is included. (AM)

  3. An Analisys of Business VPN Case Studies

    OpenAIRE

    Crescenzio Gallo; Michele Perilli; Michelangelo De Bonis

    2009-01-01

    A VPN (Virtual Private Network) simulates a secure private network through a shared public insecure infrastructure like the Internet. The VPN protocol provides a secure and reliable access from home/office on any networking technology transporting IP packets. In this article we study the standards for VPN implementation and analyze two case studies regarding a VPN between two routers and two firewalls.

  4. Collaborative Assessment: Middle School Case Study

    Science.gov (United States)

    Parkison, Paul T.

    2014-01-01

    Utilizing a participant observer research model, a case study of the efficacy of a collaborative assessment methodology within a middle school social studies class was conducted. A review of existing research revealed that students' perceptions of assessment, evaluation, and accountability influence their intrinsic motivation to learn. A…

  5. Measuring marketing performance - A case study

    OpenAIRE

    Laakso, Vesa-Pekka

    2011-01-01

    PURPOSE OF THE STUDY The purpose of this study is to develop a marketing dashboard for a Finnish company that operates in the financial industry. The identification of suitable metrics for assessing marketing performance is considered central. This study proposes a new construct (a dashboard) that aims to providing management relevant information on marketing performance from decision-making perspective. METHODOLOGY AND DATA The methodology is a constructive case study. In the...

  6. Mining Product Data Models: A Case Study

    Directory of Open Access Journals (Sweden)

    Cristina-Claudia DOLEAN

    2014-01-01

    Full Text Available This paper presents two case studies used to prove the validity of some data-flow mining algorithms. We proposed the data-flow mining algorithms because most part of mining algorithms focuses on the control-flow perspective. First case study uses event logs generated by an ERP system (Navision after we set several trackers on the data elements needed in the process analyzed; while the second case study uses the event logs generated by YAWL system. We offered a general solution of data-flow model extraction from different data sources. In order to apply the data-flow mining algorithms the event logs must comply a certain format (using InputOutput extension. But to respect this format, a set of conversion tools is needed. We depicted the conversion tools used and how we got the data-flow models. Moreover, the data-flow model is compared to the control-flow model.

  7. Cryostat design case studies, principles and engineering

    CERN Document Server

    2016-01-01

    This book enables the reader to learn the fundamental and applied aspects of practical cryostat design by examining previous design choices and resulting cryostat performance. Through a series of extended case studies the book presents an overview of existing cryostat design covering a wide range of cryostat types and applications, including the magnet cryostats that comprise the majority of the Large Hadron Collider at CERN, space-borne cryostats containing sensors operating below 1 K, and large cryogenic liquid storage vessels. It starts with an introductory section on the principles of cryostat design including practical data and equations. This section is followed by a series of case studies on existing cryostats, describing the specific requirements of the cryostat, the challenges involved and the design choices made along with the resulting performance of the cryostat. The cryostat examples used in the studies are chosen to cover a broad range of cryostat applications and the authors of each case are ...

  8. Shuttle Case Study Collection Website Development

    Science.gov (United States)

    Ransom, Khadijah S.; Johnson, Grace K.

    2012-01-01

    As a continuation from summer 2012, the Shuttle Case Study Collection has been developed using lessons learned documented by NASA engineers, analysts, and contractors. Decades of information related to processing and launching the Space Shuttle is gathered into a single database to provide educators with an alternative means to teach real-world engineering processes. The goal is to provide additional engineering materials that enhance critical thinking, decision making, and problem solving skills. During this second phase of the project, the Shuttle Case Study Collection website was developed. Extensive HTML coding to link downloadable documents, videos, and images was required, as was training to learn NASA's Content Management System (CMS) for website design. As the final stage of the collection development, the website is designed to allow for distribution of information to the public as well as for case study report submissions from other educators online.

  9. Repurposing legacy data innovative case studies

    CERN Document Server

    Berman, Jules J

    2015-01-01

    Repurposing Legacy Data: Innovative Case Studies takes a look at how data scientists have re-purposed legacy data, whether their own, or legacy data that has been donated to the public domain. Most of the data stored worldwide is legacy data-data created some time in the past, for a particular purpose, and left in obsolete formats. As with keepsakes in an attic, we retain this information thinking it may have value in the future, though we have no current use for it. The case studies in this book, from such diverse fields as cosmology, quantum physics, high-energy physics, microbiology,

  10. Case study in time series analysis

    CERN Document Server

    Zhongjie, Xie

    1993-01-01

    This book is a monograph on case studies using time series analysis, which includes the main research works applied to practical projects by the author in the past 15 years. The works cover different problems in broad fields, such as: engineering, labour protection, astronomy, physiology, endocrinology, oil development, etc. The first part of this book introduces some basic knowledge of time series analysis which is necessary for the reader to understand the methods and the theory used in the procedure for solving problems. The second part is the main part of this book - case studies in differ

  11. Protease gene families in Populus and Arabidopsis

    Directory of Open Access Journals (Sweden)

    Jansson Stefan

    2006-12-01

    Full Text Available Abstract Background Proteases play key roles in plants, maintaining strict protein quality control and degrading specific sets of proteins in response to diverse environmental and developmental stimuli. Similarities and differences between the proteases expressed in different species may give valuable insights into their physiological roles and evolution. Results We have performed a comparative analysis of protease genes in the two sequenced dicot genomes, Arabidopsis thaliana and Populus trichocarpa by using genes coding for proteases in the MEROPS database 1 for Arabidopsis to identify homologous sequences in Populus. A multigene-based phylogenetic analysis was performed. Most protease families were found to be larger in Populus than in Arabidopsis, reflecting recent genome duplication. Detailed studies on e.g. the DegP, Clp, FtsH, Lon, rhomboid and papain-Like protease families showed the pattern of gene family expansion and gene loss was complex. We finally show that different Populus tissues express unique suites of protease genes and that the mRNA levels of different classes of proteases change along a developmental gradient. Conclusion Recent gene family expansion and contractions have made the Arabidopsis and Populus complements of proteases different and this, together with expression patterns, gives indications about the roles of the individual gene products or groups of proteases.

  12. Corporate Social Responsibility : A Case Study

    OpenAIRE

    Björkqvist, Kira

    2012-01-01

    The importance of taking responsibility for the common environmental and social welfare has become of essence in the business world of the 21st century. This thesis provides the reader with knowledge on corporate social responsibility (CSR) and shows the reader a comparative study on how CSR is reported on in three case study companies chosen for this thesis. This thesis is a descriptive study that uses the research method of content analysis to determine the commonalities and differences...

  13. OCAD University's Imagination Catalyst: a Case Study.

    OpenAIRE

    Reichenbacher, Helmut

    2015-01-01

    In order to provide the context for an incubator case study, this paper provides a brief overview of the support mechanisms for Canadian university-based innovation and commercialization, especially regarding government (federal, provincial, municipal). It then proceeds to describe OCAD University’s specialized commercialization and incubator unit, the Imagination Catalyst, which supports talent

  14. Learning Machine Learning: A Case Study

    Science.gov (United States)

    Lavesson, N.

    2010-01-01

    This correspondence reports on a case study conducted in the Master's-level Machine Learning (ML) course at Blekinge Institute of Technology, Sweden. The students participated in a self-assessment test and a diagnostic test of prerequisite subjects, and their results on these tests are correlated with their achievement of the course's learning…

  15. LCA – Unique and Controversial Case Studies

    Science.gov (United States)

    This session will focus on case studies and applications that have a unique or controversial aspect. Some of the most recent topics that seem to have significant interest include: LCA-based product declarations, LCA-based standards, LCA-based labels, alternative energy, agricul...

  16. A Case Study from South Africa.

    Science.gov (United States)

    Casazza, Martha

    2000-01-01

    Presents the case study success story of a University of Port Elizabeth Advancement Program student named Elroy Africander. Underscores two significant components of student transition programs: the need for support for students' personal and emotional growth, and that practitioners should regularly assess the strengths and weaknesses of programs…

  17. WMOST v2 Case Study: Monponsett Ponds

    Science.gov (United States)

    This webinar presents an overview of the preliminary results of a case study application of EPA's Watershed Management Optimization Support Tool v2 (WMOST) for stakeholders in the Monponsett Ponds Watershed Workgroup. Monponsett Ponds is a large water system consisting of two ba...

  18. Case Studies on Globalization and Money Laundering

    OpenAIRE

    Eckhard Freyer

    2008-01-01

    Financial globalization has greatly improved the efficiency of capital transfers around the world, with the cost of facilitating criminal money laundering activities. Based on case studies on conditions for money laundering in the process of globalization and transformation in Europe, are discussed the challenges that a “global financial village” must confront.

  19. Physical Science Connected Classrooms: Case Studies

    Science.gov (United States)

    Irving, Karen; Sanalan, Vehbi; Shirley, Melissa

    2009-01-01

    Case-study descriptions of secondary and middle school classrooms in diverse contexts provide examples of how teachers implement connected classroom technology to facilitate formative assessment in science instruction. Connected classroom technology refers to a networked system of handheld devices designed for classroom use. Teachers were…

  20. The Verbal Noncommunicator: A Case Study.

    Science.gov (United States)

    Fujiki, Martin; Brinton, Bonnie

    1991-01-01

    This article presents a case study of a nine-year-old male with language impairment and specific pragmatic disabilities. His interactions with an adult, a language age-matched peer, and a chronological age-matched peer were observed and analyzed to determine conversational responsiveness and assertiveness. Findings support Fey's (1986) verbal…

  1. Acoustical case studies of three green buildings

    Science.gov (United States)

    Siebein, Gary; Lilkendey, Robert; Skorski, Stephen

    2005-04-01

    Case studies of 3 green buildings with LEED certifications that required extensive acoustical retrofit work to become satisfactory work environments for their intended user groups will be used to define areas where green building design concepts and acoustical design concepts require reconciliation. Case study 1 is an office and conference center for a city environmental education agency. Large open spaces intended to collect daylight through clerestory windows provided large, reverberant volumes with few acoustic finishes that rendered them unsuitable as open office space and a conference room/auditorium. Case Study 2 describes one of the first gold LEED buildings in the southeast whose primary design concepts were so narrowly focused on thermal and lighting issues that they often worked directly against basic acoustical requirements resulting in sound levels of NC 50-55 in classrooms and faculty offices, crosstalk between classrooms and poor room acoustics. Case study 3 is an environmental education and conference center with open public areas, very high ceilings, and all reflective surfaces made from wood and other environmentally friendly materials that result in excessive loudness when the building is used by the numbers of people which it was intended to serve.

  2. Case Studies: Windows onto Clinical Supervision.

    Science.gov (United States)

    Nolan, Jim; And Others

    1993-01-01

    By examining the structures and activities common to six case studies of clinical teacher supervision, this article identifies five conditions that facilitate changes in teacher thinking and behavior: development of a supportive, collegial relationship; teacher control over supervision products; continuity over time; focused, descriptive records…

  3. Firefighter Workplace Learning: An Exploratory Case Study

    Science.gov (United States)

    Tracey, Edward A.

    2014-01-01

    Despite there being a significant amount of research investigating workplace learning, research exploring firefighter workplace learning is almost nonexistent. The purpose of this qualitative multi-case study was to explore how firefighters conceptualize, report, and practice workplace learning. The researcher also investigated how firefighters…

  4. Performance Support Case Studies from IBM.

    Science.gov (United States)

    Duke-Moran, Celia; Swope, Ginger; Morariu, Janis; deKam, Peter

    1999-01-01

    Presents two case studies that show how IBM addressed performance support solutions and electronic learning. The first developed a performance support and expert coaching solution; the second applied performance support to reducing implementation time and total cost of ownership of enterprise resource planning systems. (Author/LRW)

  5. Climate wise case study compendium: Report 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-02-01

    This case study compendium is one of several Climate Wise tools available to help interested companies identify cost-effective options. Climate Wise, a private-public partnership program, is a key Federal initiative to return greenhouse gas emissions to 1990 levels by 2000.

  6. Teaching the Holocaust through Case Study

    Science.gov (United States)

    Misco, Thomas

    2009-01-01

    This article responds to the curricular challenges teachers face with Holocaust education, including cursory treatments and a lack of focus on individual experiences. First, the author argues for a case-study approach to help students reengage concrete and complex features of the Holocaust as a point of departure for subsequent inquiry. In…

  7. Library Virtual Tours: A Case Study

    Science.gov (United States)

    Ashmore, Beth; Grogg, Jill E.

    2004-01-01

    Virtual tours delivered via the Web have become a common tool for both instruction and outreach. This article is a case study of the creation of a virtual tour for a university library and is intended to provide others interested in creating a virtual tour of their library the opportunity to learn from the mistakes and successes of fellow…

  8. It's Not Funny: A Case Study

    Science.gov (United States)

    Méndez-Morse, Sylvia

    2015-01-01

    This case study may be used with personnel supervision, school law, and other school leadership courses. It describes the behavior and actions of one teacher toward another. Student discussions can focus on supervision, workplace mobbing, workplace bullying, as well as sexual harassment. Students should focus on a school leader's role in such…

  9. Comparative Environmental Threat Analysis: Three Case Studies.

    Science.gov (United States)

    Latour, J. B.; Reiling, R.

    1994-01-01

    Reviews how carrying capacity for different environmental problems is operationalized. Discusses whether it is possible to compare threats, using the exceeding of carrying capacity as a yardstick. Points out problems in comparative threat analysis using three case studies: threats to European groundwater resources, threats to ecosystems in Europe,…

  10. Acquaintance Rape: A Case Study Approach.

    Science.gov (United States)

    Marinelli, Rosalie D.

    1994-01-01

    Describes a case study approach to acquaintance rape used in a Personal Health and Lifestyles course at the University of Nevada in Reno that allows students to discuss the characters in a scenario, an instructional process seen as less threatening than describing personal experiences. (MDM)

  11. 3D gel map of Arabidopsis complex I

    OpenAIRE

    Katrin ePeters; Katharina eBelt; Hans-Peter eBraun

    2013-01-01

    Complex I has a unique structure in plants and includes extra subunits. Here, we present a novel study to define its protein constituents. Mitochondria were isolated from Arabidopsis thaliana cell cultures, leaves and roots. Subunits of complex I were resolved by 3D blue native (BN)/SDS/SDS-PAGE and identified by mass spectrometry. Overall, 55 distinct proteins were found, 7 of which occur in pairs of isoforms. We present evidence that Arabidopsis complex I consists of 49 distinct types of su...

  12. Arabidopsis in Wageningen

    OpenAIRE

    Koornneef, M

    2013-01-01

    Arabidopsis thaliana is the plant species that in the past 25 years has developed into the major model species in plant biology research. This was due to its properties such as short generation time, its small genome and its easiness to be transformed. Wageningen University has played an important role in the development of this model, based on interdisciplinary collaborations using genetics as a major tool to investigate aspects of physiology, development, plant-microbe interactions and evol...

  13. Case studies on selected natural food antioxidants

    OpenAIRE

    Herrero, Miguel; Mendiola, J. A.; Cifuentes, Alejandro; Ibáñez, Elena

    2013-01-01

    In this chapter, a broad description of several case studies related to common antioxidants found in food-related products is presented. In this regard, special attention is put on the novel advanced environmentally-friendly extraction methods nowadays employed to extract and purify those potent antioxidants from natural matrices. A brief description of these extraction processes is provided together with some of the instrumentation needed. Besides, the studies carried out so f...

  14. MARKET INTEGRATION: CASE STUDIES OF STRUCTURAL CHANGE

    OpenAIRE

    Franken, Jason R.V.; Parcell, Joseph L.

    2003-01-01

    The grain/oilseed industry is undergoing considerable structural change in the form of mergers and the addition of new processing facilities to add value beyond commodity grade. The rapid structural changes in this industry call into question the relevance of previous research conducted in these areas. Focusing on two structural change events in northeast Missouri as case studies provides an incisive glimpse at the larger impact of structural change on the grain/oilseed industry. This study a...

  15. Empathy Development Through Case Study and Simulation.

    Science.gov (United States)

    Mennenga, Heidi A; Bassett, Susan; Pasquariello, Libby

    2016-01-01

    Because empathy is integral to the nurse-patient relationship, nurse educators are challenged to explore teaching strategies that may aid in the development of empathy among students. The purpose of this study was to determine whether consistent exposure to a single patient through case study and simulation had an impact on empathy levels in senior-level baccalaureate nursing students. Results provide interesting conclusions for faculty members and offer a basis for ongoing discussion. PMID:26448156

  16. Success against the odds: A case study

    OpenAIRE

    Ahmadbayli, Aydan

    2015-01-01

    The purpose of this dissertation is to examine the leadership behaviours and practices necessary for school ‘turnaround’. The research was conducted by taking a multi perspective approach within a qualitative research study to explore the case of a UK based school facing ‘special measures’ and in disadvantaged circumstances. Research methods employed include a documentary study and semi-structured interviews with six members of staff. The results indicated that effective turnaround leaders em...

  17. Can We Generalize from Case Studies?

    OpenAIRE

    Paul F. Steinberg

    2015-01-01

    This article considers the role of generalization in comparative case studies, using as exemplars the contributions to this special issue on climate change politics. As a research practice, generalization is a logical argument for extending one’s claims beyond the data, positing a connection between events that were studied and those that were not. No methodological tradition is exempt from the requirement to demonstrate a compelling logic of generalization. The article presents a taxonomy of...

  18. CAT: A CASE STUDY OF GRE

    Institute of Scientific and Technical Information of China (English)

    WangZe; ChenJiliang

    2004-01-01

    The Computer Adaptive Testing (CAT) has developedsuccessfully with its adoption by testing agencies. The authors ofthis paper point out the advantages and disadvantages of CATsand then take GRE as a case study to probe into the scoringalgorithm in CAT. By analyzing some typical score reports ofcomputer-adaptive GRE General Test, they study some majorfactors affecting the final score such as the percentage ofcorrectness and difficulty levels.

  19. Mobile Technologies Adoption: An Exploratory Case Study

    Institute of Scientific and Technical Information of China (English)

    CHU Yan; HUANG Lihua

    2008-01-01

    Based on the theory of task-technology fit and literature review of mobile technology acceptance, a research model is presented based on the features of mobile technologies and the actual usage of mobile applications in business environments, which identifies the characteristics of mobile applications and fitting tasks. An exploratory case is studied to understand how ABC Company, Hong Kong, utilizes mobile selling applications in their sales management process. This study gives some managerial suggestions for enterprises to successfully use mobile applications.

  20. Pool size measurements facilitate the determination of fluxes at branching points in nonstationary metabolic flux analysis: The case of Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Robert eHeise

    2015-06-01

    Full Text Available Pool size measurements are important for the estimation of absolute intracellular fluxes in particular scenarios based on data from heavy carbon isotope experiments. Recently, steady-state fluxes estimates were obtained for central carbon metabolism in an intact illuminated rosette of Arabidopsis thaliana grown photoautotrophically (Szecowka et al., 2013; Heise et al., 2014. Fluxes were estimated therein by integrating mass-spectrometric data of the dynamics of the unlabeled metabolic fraction, data on metabolic pool sizes, partitioning of metabolic pools between cellular compartments and estimates of photosynthetically inactive pools, with a simplified model of plant central carbon metabolism. However, the fluxes were determined by treating the pool sizes as fixed parameters. Here we investigated whether and, if so, to what extent the treatment of pool sizes as parameters to be optimized in three scenarios may affect the flux estimates. The results are discussed in terms of benchmark values for canonical pathways and reactions, including starch and sucrose synthesis as well as the ribulose-1,5-bisphosphate carboxylation and oxygenation reactions. In addition, we discuss pathways emerging from a divergent branch point for which pool sizes are required for flux estimation, irrespective of the computational approach used for the simulation of the observable labelling pattern. Therefore, our findings indicate the necessity for development of techniques for accurate pool size measurements to improve the quality of flux estimates from nonstationary flux estimates in intact plant cells in the absence of alternative flux measurements.

  1. Natural genetic variation in Arabidopsis for responsiveness to plant growth-promoting rhizobacteria

    OpenAIRE

    Wintermans, P.C.A.; Bakker, P.A.H.M.; Pieterse, C.M.J.

    2016-01-01

    The plant growth-promoting rhizobacterium (PGPR) Pseudomonas simiae WCS417r stimulates lateral root formation and increases shoot growth in Arabidopsis thaliana (Arabidopsis). These plant growth-stimulating effects are partly caused by volatile organic compounds (VOCs) produced by the bacterium. Here, we performed a genome-wide association (GWA) study on natural genetic variation in Arabidopsis for the ability to profit from rhizobacteria-mediated plant growth-promotion. To this end, 302 Arab...

  2. Chloride Channel Myotonia: Study of Five Cases

    Directory of Open Access Journals (Sweden)

    M Ghofrani

    2002-09-01

    Full Text Available Chloride channel Myotonia is a form of channelopathy, and Myotonia is its manifestation. Myotonia may be defined as delayed relaxation of skeletal muscle after its contraction. Decreased chloride conductance across the transverse tubular system, renders the muscle membrane hyper-excitable and leads to repetitive firing, creating Myotonia. Myotonia congenital is another name for chloride channel Myotonia. Myotonia congenital appears in autosomal dominant type called Thomson disease, autosomal recessive type called Becker disease, and a type with sporadic occurrence. Symptoms appear in the first or second decade of life. Repeated muscle contraction, the so called warm up, result in resolution of the Myotonia stiffness. Muscle stiffness and hypertrophy is another finding at physical examination. In this study we report on 5 patients, which had clinical and electrical signs of Myotonia. Muscle hypertrophy and warm up phenomena were present in all cases. CPK measurement of all cases were normal. 2 patients underwent muscle biopsy that showed only atrophy and increased central nuclei. In three cases autosomal recessive inheritance (Becker, in one case autosomal dominant inheritance (Thomsen and in one case sporadic occurrence was suggested. With respect to successful results of carbamazepine therapy in 4 patients, and being excellent in one of them, we suggest carbamazepine for the first choice of Myotonia treatment.

  3. Nucleotide Variation in the NCED3 Region of Arabidopsis thaliana and its Association Study with Abscisic Acid Content under Drought Stress

    Institute of Scientific and Technical Information of China (English)

    Gang-Ping Hao; Xiu-Hai Zhang; Yong-Qin Wang; Zhong-Yi Wu; Cong-Lin Huang

    2009-01-01

    Drought tolerance is a comprehensive quantitative trait that is being understood further at the molecular genetic level. Abscisic acid (ABA) is the main drought-induced hormone that regulates the expression of many genes related to drought responses. 9-cis-epoxycarotenoid dioxygenase (NCED3) is thought to be a key enzyme in ABA biosynthesis. In this paper, we measured the ABA content increase under drought stress, and sequenced and compared the sequence of AtNCED3 among 22 Arabidopsis thaliana accessions. The results showed that the fold of ABA content increase under drought stress was highly variable among these accessions. High density single nucleotide polymorphism (SNP) and insertion/deletion (indel) were found in the AtNCED3 region, on average one SNP per 87.4 bp and one indel per 502 bp. Nucleotide diversity was significantly lower in the coding region than that in non-coding regions. The results of an association study with ANOVA analysis suggested that the 274th site (P←→S) and the 327th site (P←→R) amino acid variations might be the cause of ABA content increase of 163av accession under drought stress.

  4. Cell patterns emerge from coupled chemical and physical fields with cell proliferation dynamics: the Arabidopsis thaliana root as a study system.

    Directory of Open Access Journals (Sweden)

    Rafael A Barrio

    Full Text Available A central issue in developmental biology is to uncover the mechanisms by which stem cells maintain their capacity to regenerate, yet at the same time produce daughter cells that differentiate and attain their ultimate fate as a functional part of a tissue or an organ. In this paper we propose that, during development, cells within growing organs obtain positional information from a macroscopic physical field that is produced in space while cells are proliferating. This dynamical interaction triggers and responds to chemical and genetic processes that are specific to each biological system. We chose the root apical meristem of Arabidopsis thaliana to develop our dynamical model because this system is well studied at the molecular, genetic and cellular levels and has the key traits of multicellular stem-cell niches. We built a dynamical model that couples fundamental molecular mechanisms of the cell cycle to a tension physical field and to auxin dynamics, both of which are known to play a role in root development. We perform extensive numerical calculations that allow for quantitative comparison with experimental measurements that consider the cellular patterns at the root tip. Our model recovers, as an emergent pattern, the transition from proliferative to transition and elongation domains, characteristic of stem-cell niches in multicellular organisms. In addition, we successfully predict altered cellular patterns that are expected under various applied auxin treatments or modified physical growth conditions. Our modeling platform may be extended to explicitly consider gene regulatory networks or to treat other developmental systems.

  5. Using case studies in management education: the student perspective.

    OpenAIRE

    BRENNAN, ROSS; Ahmad, S. Jaseem

    2005-01-01

    Case studies are widely used in management education. Most of the literature discussing the case study method has reflected the perspective of the teacher, implying a teacher-centred view of the case study as a learning strategy. Little is known about the student perspective on case studies. If we are to use the case study method as a component of a student-centred learning experience, then we must know how students perceive case studies, and understand the differences in attitude...

  6. Vitiligo: A study of 120 cases

    Directory of Open Access Journals (Sweden)

    Kar P

    2001-11-01

    Full Text Available Vitiligo is a common pignientary disorder and of major social and cosmetic concern in India. Purpose of the study was to find out age at onset and sex incidence in vitiligo, role of hereditary factors and associations with other diseases. 120 self reporting vitiligo patients attending out patient department of a service hospital were selected for the study and this data was analysed. In the present series out of 120 cases 62 (51.6% were males and 58(48.35%were females. There was practically no difference in sex incidence. The lowest age of onset was two years and the oldest was 65 years. In the majority of patients,52(43.2%, disease started before twenty years of age.8 (6.6% cases gave definite family history of vitiligo. Exposed areas of the body were commonly affected in majority (66.6% of cases. The legs were commonest site of involvement in 60(50% cases. Circunicript type of vitiligo (46.6% was heading the list. Majority of patients (56.6% had multiple lesions. Diabetes mellitus was found in 2 (2.6% patients. Cause of vitiligo is still idiopathic. Hereditary factors hardly play any role in manifestation of vitiligo

  7. Case studies of nurseries in Malawi

    DEFF Research Database (Denmark)

    Namoto, M.; Likoswe, M.G.

    This study of 42 case studies of nurseries was made as part of a major sample survey of 360 nurseries in 6 districts in Malawi. The purpose of the study was to let the small nurseries in the country explain in their own words how they source seed, how and for whom they produce seedlings, and to...... explain about their problems and opportunities in the nursery business. The assessment was made within the framework of Improved Seed Supply for Agroforestry in African Countries (ISSAAC), a Danida supported programme implemented in cooperation between Forest & Landscape Denmark and World Agroforestry...

  8. The Pendulum A Case Study in Physics

    CERN Document Server

    Baker, Gregory L

    2005-01-01

    The pendulum: a case study in physics is a unique book in several ways. Firstly, it is a comprehensive quantitative study of one physical system, the pendulum, from the viewpoint of elementary and more advanced classical physics, modern chaotic dynamics, and quantum mechanics. In addition, coupled pendulums and pendulum analogs of superconducting devices are also discussed. Secondly, this book treats the physics of the pendulum within a historical and cultural context,showing, for example, that the pendulum has been intimately connected with studies of the earth's density, the earth's motion,

  9. Management & Communication: Project Management Case Study

    CERN Multimedia

    Nathalie Dumeaux

    2004-01-01

    We are pleased to announce the recent launch of a new workshop on Project Management. This is designed for People with budgetary, scheduling and/or organizational responsibilities in a project or a sub-project. The objectives through a management case study specially suited to CERN are: to become familiar with modern management techniques in use for structuring, planning, scheduling, costing and progress monitoring of a project or a sub-project. to understand in-depth issues associated with Deliverable-oriented Project Management, Earned Value Management, Advanced Project Cost Engineering and Project Risk Management. The full description of this workshop can be found here. The next session will be held on 8 October 2004. If you are interested in this workshop, please contact Nathalie Dumeaux, email or 78144. Programme of Seminars October to December 2004 Situation : 21.09.2004 Séminaires bilingues Dates Jours Places disponibles Project Management Case study 8 October 1 oui Intr...

  10. Marketing and clinical trials: a case study

    Directory of Open Access Journals (Sweden)

    Entwistle Vikki A

    2007-11-01

    Full Text Available Abstract Background Publicly funded clinical trials require a substantial commitment of time and money. To ensure that sufficient numbers of patients are recruited it is essential that they address important questions in a rigorous manner and are managed well, adopting effective marketing strategies. Methods Using methods of analysis drawn from management studies, this paper presents a structured assessment framework or reference model, derived from a case analysis of the MRC's CRASH trial, of 12 factors that may affect the success of the marketing and sales activities associated with clinical trials. Results The case study demonstrates that trials need various categories of people to buy in – hence, to be successful, trialists must embrace marketing strategies to some extent. Conclusion The performance of future clinical trials could be enhanced if trialists routinely considered these factors.

  11. The Graduate Experience: Living and Studying Abroad (A Case Study

    Directory of Open Access Journals (Sweden)

    Rosario Hernández Castañeda

    2008-11-01

    Full Text Available This article is a qualitative case study describing the experience of Angélica an international graduate student from Latin America, who received her doctorate at the University of New Mexico in the United States. Her case demonstrated how administrators and faculty learn about the experience and struggles endured by international students, especially those who learned English a short time before admission to graduate studies. While a single case is understandably idiographic in nature and inevitably requires a larger sample, from the analysis of Angélica’s case and the analysis of the relevant literature common topics emerged persuading me to conclude that the issues that commonly impact the life of international students have to do with: 1 second language problems; 2 the quality of academic advisement received; 3 the availability of financial support; 4 the level of integration into their academic program; and 5 the level of cultural adjustment in their host country.

  12. BOOK REVIEW: Case Studies in Knowledge Management

    OpenAIRE

    Reviewed by Dr. Adnan BOYACI

    2005-01-01

    161Case Studies in Knowledge ManagementEdited by Murray JennexHersley: PA: Idea Group, 2005, pp. 372, ISBN 1-59140-352-9Reviewed by Dr. Adnan BOYACIAnadolu UniversityEskişehir-TurkeyKnowledge management (KM) as a structured system and the way to the effectiveness isrelatively new field for the contemporary organizations functioning in different andcompetitive domain of public and private sectors in terms of getting optimal effectivenessunderlined by the concepts such as quality, productivity…...

  13. Gamification in teaching music : case study

    OpenAIRE

    Gomes, Cristina; Figueiredo, Mauro; Bidarra, José

    2014-01-01

    The study presented here aims to assess the quality of learning that occurred by the introduction of an educational application in the teaching/learning process of music education – 2nd cycle of basic education. The investigation focused on the use of a set of multimedia materials designed to provide support for instrumental practice (recorder and guitar) and backing vocals, according to the technique of the sing along. The students had access to the materials in two ways: in the first case, ...

  14. Case Study on Inventory Management Improvement

    OpenAIRE

    Plinere Darya; Borisov Arkady

    2015-01-01

    Inventory management is a challenging problem area in supply chain management. Companies need to have inventories in warehouses in order to fulfil customer demand, meanwhile these inventories have holding costs and this is frozen fund that can be lost. Therefore, the task of inventory management is to find the quantity of inventories that will fulfil the demand, avoiding overstocks. This paper presents a case study for the assembling company on inventory management. It is proposed to use inve...

  15. Private power financing: a case study

    International Nuclear Information System (INIS)

    The Public Utility Regulatory Power Act (PURPA) in the USA and the UK's Electricity Act passed in 1989 are discussed and the first UK private power project is considered. A case study is presented, and covers the questions of when to approach the bank; banker versus investment bank; project fundamentals; the sponsor and the management team; the strength of the key project agreements; syndication of the project debt; and bank support during construction and operation. (author)

  16. Six Case Studies of Economically Successful Cities

    OpenAIRE

    Kulenovic, Z. Joe; Cech, Alexandra

    2015-01-01

    The objective of this paper is to synthesize the findings of six individual case studies (Bucaramanga, Colombia; Coimbatore, India; Kigali, Rwanda; Gaziantep, Turkey; Changsha, China; and Tangier, Morocco) by analyzing the similarities and dissimilarities among them and identifying common, cross-cutting themes. The intent is to highlight what institutions and strategies successful cities have relied on to spur economic development, under what conditions such success has occurred, and what ...

  17. Systemic Design: Two Canadian Case Studies

    OpenAIRE

    Alex Ryan; Mark Leung

    2014-01-01

    This paper introduces two novel applications of systemic design to facilitate a comparison of alternative methodologies that integrate systems thinking and design. In the first case study, systemic design helped the Procurement Department at the University of Toronto re-envision how public policy is implemented and how value is created in the broader university purchasing ecosystem. This resulted in an estimated $1.5 million in savings in the first year, and a rise in user retention rates fro...

  18. Customer Buying Behavior : Case Study: Algol Technics

    OpenAIRE

    Weckman, Nina

    2009-01-01

    The purpose of this study is to research the customer buying behavior in a specific market. This thesis is made for a subgroup of Algol Technics which specializes in the marketing of driver seats. The research areas included brand recognition, price and quality, as well as the communications channels. The theoretical framework presented consists of the marketing strategies, marketing mix, Porter’s five forces analysis, customer relationship marketing, and market analysis. The case compan...

  19. Six case studies of contents tourism

    OpenAIRE

    Seaton, Philip

    2015-01-01

    This short series of research notes brings together some of the case studies that have been researched by members of the project ‘International Comparative Research on the Spreading and Reception of Culture through Contents Tourism’. This research has been funded since April 2014 by a Japan Society for the Promotion of Science grant (Kiban A, grant number 26243007). However, the project had its roots in a small group research project started in the Research Faculty of Media and...

  20. Case Study for Holylight(HK)

    OpenAIRE

    Ha, Kong Ho

    2013-01-01

    In this thesis the case company – Holylight (HK) was thoroughly studied. The company structure, business strategic management and Marketing mix (4ps) were analyzed using SWOT analysis. It was found that Holylight (HK) had huge poten-tial in the business its stable supplies from the United States of America, Europe and Australia; Alliance partnership company ensure the steady sales channel in potential market – China that further development and expansion are highly feasible. However th...

  1. Hawaii Macadamia Nut Company- A Case Study

    OpenAIRE

    George H. (Jody) Tompson; Dan Verreault; Tompson, Holly B.

    2009-01-01

    Owners of the Hawaii Macadamia Nut Company (HMNC) are facing an expansion opportunity. A land owner has preperty available that would enable the HMNC to expand its acreage and revenue by about 20%. To fully consider this opportunity the owners must decide 1)whether the expansion is strategically and financially viable, 2)how to raise capital to finance the expansion, and 3)whether they have the skills to manage the company's growth during expansion. This is a case study describing a real comp...

  2. Telepractice for Pediatric Dysphagia: A Case Study

    OpenAIRE

    Malandraki, Georgia A.; Melissa Roth; Justine Joan Sheppard

    2014-01-01

    A closed-ended intensive pediatric swallowing telepractice program was developed and piloted in one pediatric patient with Opitz BBB/G and Asperger’s Syndromes, oropharyngeal dysphagia and aerophagia. The present study is a case report. Outcome variables included behavioral, swallowing and quality of life variables, and were assessed at baseline and at the end of the four-week program. Selective variables were also assessed at a follow-up family interview four weeks post program completion. O...

  3. Rumination Syndrome in Ethiopia: A Case Study

    OpenAIRE

    Bruni, Andrea

    2014-01-01

    Eating disorders are commonly believed to be rare or nonexistent in Africa. However, due to exposure to Western culture, a rise in eating disorders among African women is reported in the literature. This case study describes a 17-year-old Ethiopian girl who meets the DSM-IV-TR and DSM-5 diagnostic criteria for bulimia nervosa and the Rome III Diagnostic Criteria for Functional Gastrointestinal Disorders criteria for rumination syndrome. The article discusses the diagnostic delays, the difficu...

  4. Power and organisational change: a case study

    OpenAIRE

    João Pedro Oliveira

    2010-01-01

    This thesis reports the results of a case study conducted in a Portuguese manufacturing organization, a part of a large group, which endured profound organizational changes. The initial objective of the research was to explore, in a processual way, the long-term interactions between an Enterprise Resource Planning (ERP) system, the consultants that implemented it and management accounting and control, in this organization. However, during the fieldwork, the researcher was confronted with an a...

  5. Mobile phone surveys: the Slovenian case study

    OpenAIRE

    VEHOVAR Vasja; Belak, Eva; Batagelj, Zenel; Čikić, Sanja

    2014-01-01

    almost 10% of households are now available only over the mobile phone. With this, Slovenia positions itself as a typical EU country andcan serve as a case study for issues related to mobile phone interview surveys. The paper addresses the general context of mobile phone usage and thecalculations of mobile phone coverage rates. It also discusses the non-coverage problems related to mobile and mobile-only households. It is shown, that even with a relatively small non-coverage the corresponding ...

  6. Mobile phone surveys: the Slovenian case study:

    OpenAIRE

    Batagelj, Zenel; Belak, Eva; Čikić, Sanja; VEHOVAR Vasja

    2004-01-01

    In 2004, the number of mobile phone subscriptions in Slovenia reached the total number of inhabitants. Consequently, the fixed telephone coverage has started to decline; almost 10% of households are now available only over the mobile phone. With this, Slovenia positions itself as a typical EU country and can serve as a case study for issues related to mobile phone interview surveys. The paper addresses the general context of mobile phone usage and the calculations of mobile phone coverage rat...

  7. Case studies of soil in art

    Science.gov (United States)

    Feller, C.; Landa, E. R.; Toland, A.; Wessolek, G.

    2015-08-01

    The material and symbolic appropriations of soil in artworks are numerous and diverse, spanning many centuries and artistic traditions, from prehistoric painting and ceramics to early Renaissance works in Western literature, poetry, paintings, and sculpture, to recent developments in film, architecture, and contemporary art. Case studies focused on painting, installation, and film are presented with the view of encouraging further exploration of art about, in, and with soil as a contribution to raising soil awareness.

  8. Case study: Wireless Sensor Networks Technology

    OpenAIRE

    Naveen Jain; Pawan Shakdwipee; Sunil Sharma

    2013-01-01

    This paper present the history of research in sensor networks over the past decades, including two important programs of the Defense Advanced Research Projects Agency (DARPA), and the Distributed Sensor Networks (DSN) and the Sensor Information Technology (SensIT) programs. Technology trends that impact the development of sensor networks are reviewed, and new applications such as infrastructure security, habitat monitoring. The paper concludes by presenting some recent case studies results in...

  9. A Codesign Case Study in Computer Graphics

    OpenAIRE

    Brage, Jens P.; Madsen, Jan

    1994-01-01

    The paper describes a codesign case study where a computer graphics application is examined with the intention to speed up its execution. The application is specified as a C program, and is characterized by the lack of a simple compute-intensive kernel. The hardware/software partitioning is based on information obtained from software profiling and the resulting design is validated through cosimulation. A locally developed interface model, Merlin, is used as the basis for co-simulation. The ac...

  10. A warehouse design decision model: case study

    OpenAIRE

    Geraldes, Carla A. S.; Carvalho, Maria do Sameiro; Pereira, Guilherme

    2008-01-01

    Today’s competitive and volatile market requires flexibility, quality and efficiency from the logistics operations. In this context, warehouses are an important link of the logistic chain and warehouse management plays an important role over customer's service. Throughout this work we analyze a mathematical model aiming to support warehouse management decisions. A case study is used for that purpose and the model jointly identifies product allocation to the functional areas in the warehouse, ...

  11. Web Fuzzy Clustering and a Case Study

    Institute of Scientific and Technical Information of China (English)

    LIU Mao-fu; HE Jing; HE Yan-xiang; HU Hui-jun

    2004-01-01

    We combine the web usage mining and fuzzy clustering and give the concept of web fuzzy clustering, and then put forward the web fuzzy clustering processing model which is discussed in detail. Web fuzzy clustering can be used in the web users clustering and web pages clustering. In the end, a case study is given and the result has proved the feasibility of using web fuzzy clustering in web pages clustering.

  12. Marketing and clinical trials: a case study

    OpenAIRE

    Entwistle Vikki A; Snowdon Claire; Garcia Jo; Knight Rosemary C; Shakur Haleema; Elbourne Diana R; Roberts Ian; Francis David; McDonald Alison M; Grant Adrian M; Campbell Marion K

    2007-01-01

    Abstract Background Publicly funded clinical trials require a substantial commitment of time and money. To ensure that sufficient numbers of patients are recruited it is essential that they address important questions in a rigorous manner and are managed well, adopting effective marketing strategies. Methods Using methods of analysis drawn from management studies, this paper presents a structured assessment framework or reference model, derived from a case analysis of the MRC's CRASH trial, o...

  13. Shuttle Transportation System Case-Study Development

    Science.gov (United States)

    Ransom, Khadijah

    2012-01-01

    A case-study collection was developed for NASA's Space Shuttle Program. Using lessons learned and documented by NASA KSC engineers, analysts, and contractors, decades of information related to processing and launching the Space Shuttle was gathered into a single database. The goal was to provide educators with an alternative means to teach real-world engineering processes and to enhance critical thinking, decision making, and problem solving skills. Suggested formats were created to assist both external educators and internal NASA employees to develop and contribute their own case-study reports to share with other educators and students. Via group project, class discussion, or open-ended research format, students will be introduced to the unique decision making process related to Shuttle missions and development. Teaching notes, images, and related documents will be made accessible to the public for presentation of Space Shuttle reports. Lessons investigated included the engine cutoff (ECO) sensor anomaly which occurred during mission STS-114. Students will be presented with general mission infom1ation as well as an explanation of ECO sensors. The project will conclude with the design of a website that allows for distribution of information to the public as well as case-study report submissions from other educators online.

  14. Systemic Design: Two Canadian Case Studies

    Directory of Open Access Journals (Sweden)

    Alex Ryan

    2014-12-01

    Full Text Available This paper introduces two novel applications of systemic design to facilitate a comparison of alternative methodologies that integrate systems thinking and design. In the first case study, systemic design helped the Procurement Department at the University of Toronto re-envision how public policy is implemented and how value is created in the broader university purchasing ecosystem. This resulted in an estimated $1.5 million in savings in the first year, and a rise in user retention rates from 40% to 99%. In the second case study, systemic design helped the clean energy and natural resources group within the Government of Alberta to design a more efficient and effective resource management system and shift the way that natural resource departments work together. This resulted in the formation of a standing systemic design team and contributed to the creation of an integrated resource management system. A comparative analysis of the two projects identifies a shared set of core principles for systemic design as well as areas of differentiation that reveal potential for learning across methodologies. Together, these case studies demonstrate the complementarity of systems thinking and design thinking, and show how they may be integrated to guide positive change within complex sociotechnical systems.

  15. Studies on the role of heavy-metal transporting P-type ATPase family genes on zinc (Zn) transport and accumulation in Arabidopsis thaliana

    Energy Technology Data Exchange (ETDEWEB)

    Bagavathiannan, M.V. [Manitoba Univ., Winnipeg, MB (Canada). Dept. of Plant Science; Broadley, M.R.; Donnelly, S.J.; Smith, R.J.; Mills, V. [Nottingham Univ., Loughborough, Leicestershire (United Kingdom). School of Biosciences, Plant Sciences Division

    2006-07-01

    Although zinc (Zn) is an essential plant mineral nutrient for normal crop growth, excess amounts can cause environmental contamination problems. Higher amounts of Zn are added into soils every year through effluents from tanning industries and other sources such as sewage treatment plants, metal inputs from rivers and the atmosphere. Studies have shown that specific metal tolerances exist at the cellular level in plants, indicating that specific adaptations to metal ions occur in cells as well as in the whole plant. This paper described the mechanisms that plants develop in order to tolerate heavy metals and showed that transporter genes play a key role in uptake and sequestration of heavy metals in plant systems. Since metal ion transporting genes are also involved in transport and homeostasis of heavy metals in plants, this study examined the role of the metal ion transporting gene family members in Zn transport and tolerance in plant systems. Among the metal ion transporting gene families, P-type ATPase gene family members are considered to be efficient in metal transport in the model plant Arabidopsis thaliana. They form a diverse superfamily of transporters which carry a range of essential and potentially toxic metals across cellular membranes. Genetic-screening experiments were performed in which 3 SALK lines with known disruption in the target gene were studied physiologically and at the molecular level to determine their role in heavy-metal transportation and accumulation. The study showed that one of the family lines may have altered Zn tolerance and uptake characteristics. Ongoing research continues to examine the characteristics of this line. 27 refs., 1 tab., 8 figs.

  16. In Vitro Morphogenesis of Arabidopsis to Search for Novel Endophytic Fungi Modulating Plant Growth.

    Directory of Open Access Journals (Sweden)

    Francesco Dovana

    Full Text Available Fungal endophytes have shown to affect plant growth and to confer stress tolerance to the host; however, effects of endophytes isolated from water plants have been poorly investigated. In this study, fungi isolated from stems (stem-E and roots (root-E of Mentha aquatica L. (water mint were identified, and their morphogenetic properties analysed on in vitro cultured Arabidopsis (L. Heynh., 14 and 21 days after inoculation (DAI. Nineteen fungi were analysed and, based on ITS analysis, 17 isolates showed to be genetically distinct. The overall effect of water mint endophytes on Arabidopsis fresh (FW and dry weight (DW was neutral and positive, respectively, and the increased DW, mainly occurring 14 DAI, was possibly related to plant defence mechanism. Only three fungi increased both FW and DW of Arabidopsis at 14 and 21 DAI, thus behaving as plant growth promoting (PGP fungi. E-treatment caused a reduction of root depth and primary root length in most cases and inhibition-to-promotion of root area and lateral root length, from 14 DAI. Only Phoma macrostoma, among the water mint PGP fungi, increased both root area and depth, 21 DAI. Root depth and area 14 DAI were shown to influence DWs, indicating that the extension of the root system, and thus nutrient uptake, was an important determinant of plant dry biomass. Reduction of Arabidopsis root depth occurred to a great extent when plants where treated with stem-E while root area decreased or increased under the effects of stem-E and root-E, respectively, pointing to an influence of the endophyte origin on root extension. M. aquatica and many other perennial hydrophytes have growing worldwide application in water pollution remediation. The present study provided a model for directed screening of endophytes able to modulate plant growth in the perspective of future field applications of these fungi.

  17. Capturing Cultural Glossaries: Case-study II

    Directory of Open Access Journals (Sweden)

    Matete Madiba

    2011-10-01

    Full Text Available

    ABSTRACT: This case-study attempts to present a brief glossary of Northern Sotho medical terms. It is a follow-up of a similar case-study (Madiba, Mphahlele and Kganyago 2003, which was an attempt to capture and present Northern Sotho cooking terms. Case-study I consists of the names for utensils, ingredients and the processes involved in the preparation of cultural dishes. With both these case-studies, the intention has been to use the opportunities availing themselves for the pres-ervation and valorisation of Northern Sotho, including the extension of its corpora to support national dictionary-making processes. The case-study methodology has been very useful for the purposes of this project and the context within which it was undertaken. It aims to provide a model for the collection and presentation of authentic Northern Sotho terminology which otherwise would hardly have been accessible.

    Keywords: CULTURAL GLOSSARY, INDIGENOUS KNOWLEDGE SYSTEMS, CORPUS, OUTCOMES-BASED EDUCATION, ASSESSMENT CRITERIA, TRADITIONAL MEDICAL TERMS, COMMUNICATIVE APPROACH, STRUCTURAL APPROACH, METONYMY, HANDS-ON ACTIVITIES, TASK-BASED LEARNING

    *****

    OPSOMMING: Die totstandbrenging van kulturele woordversamelings: Ge-vallestudie II. Hierdie gevallestudie probeer om 'n beperkte woordelys van Noord-Sotho- mediese terme aan te bied. Dit is 'n voortsetting van 'n soortgelyke gevallestudie (Madiba, Mpha-hlele en Kganyago 2003 wat 'n poging was om Noord-Sothokookterme te versamel en aan te bied. Gevallestudie I bestaan uit die name van gereedskap, bestanddele, en die prosesse betrokke by die voorbereiding van kulturele geregte. Met altwee hierdie gevallestudies was die bedoeling om die geleenthede te gebruik wat hulleself aanbied vir die bewaring en bestendiging van Noord-Sotho, insluitende die uitbreiding van sy korpora om die nasionale woordeboeksamestellingsprosesse te ondersteun. Die gevallestudiemetodologie was baie nuttig vir die doeleindes van

  18. Case studies in atomic collision physics

    CERN Document Server

    McDaniel, E W

    2013-01-01

    Case Studies in Atomic Collision Physics II focuses on studies on the role of atomic collision processes in astrophysical plasmas, including ionic recombination, electron transport, and position scattering. The book first discusses three-body recombination of positive and negative ions, as well as introduction to ionic recombination, calculation of the recombination coefficient, ions recombining in their parent gas, and three-body recombination at moderate and high gas-densities. The manuscript also takes a look at precision measurements of electron transport coefficients and differential cr

  19. Using Case Studies to Teach About Global Issues, Bali: A Case Study

    Science.gov (United States)

    Oswald, James M.

    1974-01-01

    The South Pacific island of Bali is used as a case study of overpopulation and food shortage. A brief description of the resources, the typical lifestyle of the Balinese farmer, and possible teaching techniques are given. (DE)

  20. Using Case Study Analysis and Case Writing to Structure Clinical Experiences in a Teacher Education Program

    Science.gov (United States)

    Floyd, Deborah M.; Bodur, Yasar

    2005-01-01

    This study reports on the design and results of a two-semester study on the use of case study analysis and case writing in clinical experiences in an undergraduate teacher education program. Findings indicated that structured experiences with case studies and case writing increase preservice teachers' informed decision making on educational…

  1. The case study of biomaterials and biominerals

    Science.gov (United States)

    Del Hoyo Martínez, Carmen

    2013-04-01

    The teaching of biomaterials as case study by on-line platform , susceptible to develop both individually and in groups, got different objectives proposed by the European Higher Education System, among which include: participate actively in the teaching-learning process by students, interpreting situations, adapt processes and solutions. It also improves oral and written communication, analytical skills and synthesis and also the ability to think critically. Biomaterials have their origin in biominerals. These are solid inorganic compounds of defined structure, consisting of molecular control mechanisms that operate in biological systems. Its main functions are: structural support, a reservoir of essential elements, sensors, mechanical protection and storage of toxic elements. Following the demand of materials compatible with certain functional systems of our body, developed biomaterials. Always meet the condition of biocompatibility. Should be tolerated by the body and do not provoke rejection. This involves a comprehensive study of physiological conditions and the anatomy of the body where a biomaterial has to be implemented. The possibility of generating new materials from biominerals has a major impact in medicine and other fields could reach as geology, construction, crystallography, etc. While the study of these issues is in its infancy today, can be viewed as an impact on the art and future technology. Planning case study that students would prepare its report for discussion in subgroups. Occurs then the pooling of individual analysis, joint case discussion and adoption by the subgroup of a consensual solution to the problem. The teacher as facilitator and coordinator of the final case analysis, sharing leads to group-wide class and said the unanimous decision reached by the students and gives his opinion on the resolution of the case. REFERENCES D.P. Ausubel. Psicología Educativa. Un punto de vista cognoscitivo. Trillas. Ed. 1983. E.W. Eisner. Procesos

  2. The Danish National Case Study Report

    DEFF Research Database (Denmark)

    Brodersen, Søsser; Jørgensen, Michael Søgaard

    This report is the Danish case study report in the EU-financed project INTERACTS, which analyses experience and expectations to the interaction between NGOs, Science Shops and universities. The report analyses potentials and barriers to NGO’s and similar civil society groups’ use of research and...... pond. Each case is described and reflected separately. A cross-analysis analyses the interactions among the involved actor group (clients, students, researchers, and Science Shops) discussing how the knowledge in the projects were developed and how the knowledge were used by the actors to try to gain...... impact on either research development or societal discourses. When civil society groups request assistance through the Science Shops, their need for knowledge and research is based on a need for scientific documentation of a certain topic, a need for enhancement of new knowledge and/or a need for...

  3. An Arabidopsis callose synthase

    DEFF Research Database (Denmark)

    Ostergaard, Lars; Petersen, Morten; Mattsson, Ole;

    2002-01-01

    unclear whether callose synthases can also produce cellulose and whether plant cellulose synthases may also produce beta-1,3-glucans. We describe here an Arabidopsis gene, AtGsl5, encoding a plasma membrane-localized protein homologous to yeast beta-1,3-glucan synthase whose expression partially......Beta-1,3-glucan polymers are major structural components of fungal cell walls, while cellulosic beta-1,4-glucan is the predominant polysaccharide in plant cell walls. Plant beta-1,3-glucan, called callose, is produced in pollen and in response to pathogen attack and wounding, but it has been...

  4. Guidelines for Conducting Positivist Case Study Research in Information Systems

    OpenAIRE

    Graeme Shanks

    2002-01-01

    The case study research approach is widely used in a number of different ways within the information systems community. This paper focuses on positivist, deductive case study research in information systems. It provides clear definitions of important concepts in positivist case study research and illustrates these with an example research study. A critical analysis of the conduct and outcomes of two recently published positivist case studies is reported. One is a multiple case study that vali...

  5. Analyzing Synthetic Promoters Using Arabidopsis Protoplasts.

    Science.gov (United States)

    Stracke, Ralf; Thiedig, Katharina; Kuhlmann, Melanie; Weisshaar, Bernd

    2016-01-01

    This chapter describes a transient protoplast co-transfection method that can be used to quantitatively study in vivo the activity and function of promoters and promoter elements (reporters), and their induction or repression by transcription factors (effectors), stresses, hormones, or metabolites. A detailed protocol for carrying out transient co-transfection assays with Arabidopsis At7 protoplasts and calculating the promoter activity is provided. PMID:27557761

  6. Gene expression studies in kiwifruit and gene over-expression in Arabidopsis indicates that GDP-L-galactose guanyltransferase is a major control point of vitamin C biosynthesis

    Science.gov (United States)

    Bulley, Sean M.; Rassam, Maysoon; Hoser, Dana; Otto, Wolfgang; Schünemann, Nicole; Wright, Michele; MacRae, Elspeth; Gleave, Andrew; Laing, William

    2009-01-01

    Vitamin C (L-ascorbic acid, AsA) is an essential metabolite for plants and animals. Kiwifruit (Actinidia spp.) are a rich dietary source of AsA for humans. To understand AsA biosynthesis in kiwifruit, AsA levels and the relative expression of genes putatively involved in AsA biosynthesis, regeneration, and transport were correlated by quantitative polymerase chain reaction in leaves and during fruit development in four kiwifruit genotypes (three species; A. eriantha, A. chinensis, and A. deliciosa). During fruit development, fruit AsA concentration peaked between 4 and 6 weeks after anthesis with A. eriantha having 3–16-fold higher AsA than other genotypes. The rise in AsA concentration typically occurred close to the peak in expression of the L-galactose pathway biosynthetic genes, particularly the GDP-L-galactose guanyltransferase gene. The high concentration of AsA found in the fruit of A. eriantha is probably due to higher expression of the GDP-mannose-3′,5′-epimerase and GDP-L-galactose guanyltransferase genes. Over-expression of the kiwifruit GDP-L-galactose guanyltransferase gene in Arabidopsis resulted in up to a 4-fold increase in AsA, while up to a 7-fold increase in AsA was observed in transient expression studies where both GDP-L-galactose guanyltransferase and GDP-mannose-3′,5′-epimerase genes were co-expressed. These studies show the importance of GDP-L-galactose guanyltransferase as a rate-limiting step to AsA, and demonstrate how AsA can be significantly increased in plants. PMID:19129165

  7. Environmental qualification - facilities and case studies

    International Nuclear Information System (INIS)

    The term environmental qualification is used for assurance or guarantee for satisfactory performance of hardware under specified environmental conditions including normal, abnormal and accident conditions. To generate confidence about satisfactory performance in reasonable time, hardware must be tested under accelerated conditions. For testing and measuring performance parameters, it is essential to have adequate facilities and experienced and inquisitive staff so that qualified and reliable hardware can be manufactured by active participation of manufacturers, users and researchers. Top priority is given to the determination of characteristics, capabilities and limitations of hardware before really starting accelerated testing so that maximum information can be extracted before failure of hardware. This paper describes test and measurement facilities set up at the Bhabha Atomic Research Centre for environmental qualification and some case studies where it has been possible to make significant contributions towards reliability assessment, upgrading and indigenisation. Apart from climatic test facilities (thermal and humidity chambers), a Loss Of Coolant Accident (LOCA) environment simulator and synergistic simulator (combined environment test facility comprising temperature, humidity, gamma radiation and electrical stresses for studying interaction effects) have been set up. Notable case studies are :(1) Assessment of residual life-spans of cables and elastomeric components, (2) Reliability upgradation of indicating alarm meters and solenoid valves, (3) Assessment of survival capability of process instruments under LOCA environment, (4)Assessment of reusability of relays exposed to smoke and water spray in fire incident in a nuclear power station. (author)

  8. Case Study of the California Cement Industry

    OpenAIRE

    Coito, Fred; Powell, Frank; Worrell, Ernst; Price, Lynn; Friedmann, Rafael

    2005-01-01

    California is the largest cement producing state in the U.S., accounting for between 10 percent and 15 percent of U.S. cement production and cement industry employment. The cement industry in California consists of 31 sites that consume large amounts of energy, annually: 1,600 GWh of electricity, 22 million therms of natural gas, 2.3 million tons of coal, 0.25 tons of coke, and smaller amounts of waste materials, including tires. The case study summarized in this paper focused on providi...

  9. Metrology in Pharmaceutical Industry - A Case Study

    Science.gov (United States)

    Yuvamoto, Priscila D.; Fermam, Ricardo K. S.; Nascimento, Elizabeth S.

    2016-07-01

    Metrology is recognized by improving production process, increasing the productivity, giving more reliability to the measurements and consequently, it impacts in the economy of a country. Pharmaceutical area developed GMP (Good Manufacture Practice) requeriments, with no introduction of metrological concepts. However, due to Nanomedicines, it is expected this approach and the consequent positive results. The aim of this work is to verify the level of metrology implementation in a Brazilian pharmaceutical industry, using a case study. The purpose is a better mutual comprehension by both areas, acting together and governmental support to robustness of Brazilian pharmaceutical area.

  10. A Codesign Case Study in Computer Graphics

    DEFF Research Database (Denmark)

    Brage, Jens P.; Madsen, Jan

    1994-01-01

    The paper describes a codesign case study where a computer graphics application is examined with the intention to speed up its execution. The application is specified as a C program, and is characterized by the lack of a simple compute-intensive kernel. The hardware/software partitioning is based...... on information obtained from software profiling and the resulting design is validated through cosimulation. A locally developed interface model, Merlin, is used as the basis for co-simulation. The achieved speed-up is estimated based on an analysis of profile information....

  11. Russian Media Educators: Case Studies Portraits

    Directory of Open Access Journals (Sweden)

    Alexander Fedorov

    2013-01-01

    Full Text Available This article is devoted to case studies of the media education works of some well knowns Russian media educators. The analysis of media educational work of the famous Russian media educators leads us to the conclusion that media education in Russia is developing, building on the synthesis of the aesthetic, socio-cultural, and practical concepts, with a focus on the development of media competence of the audience, mainly school and youth. The enthusiasts of media education, even devoid of substantial public support for its innovative projects, achieve significant and meaningful results.

  12. Reinforcement learning: Solving two case studies

    Science.gov (United States)

    Duarte, Ana Filipa; Silva, Pedro; dos Santos, Cristina Peixoto

    2012-09-01

    Reinforcement Learning algorithms offer interesting features for the control of autonomous systems, such as the ability to learn from direct interaction with the environment, and the use of a simple reward signalas opposed to the input-outputs pairsused in classic supervised learning. The reward signal indicates the success of failure of the actions executed by the agent in the environment. In this work, are described RL algorithmsapplied to two case studies: the Crawler robot and the widely known inverted pendulum. We explore RL capabilities to autonomously learn a basic locomotion pattern in the Crawler, andapproach the balancing problem of biped locomotion using the inverted pendulum.

  13. Case study: Bioremediation in the Aleutian Islands

    International Nuclear Information System (INIS)

    This case study describes the design, construction, and operation of a bioremediation pile on Adak Island, which is located in the Aleutian Island chain. Approximately 1,900 m3 of petroleum-contaminated soil were placed in the bioremediation pile. The natural bioremediation process was enhanced by an oxygen and nutrient addition system to stimulate microbial activity. Despite the harsh weather on the island, after the first 6 months of operation, laboratory analyses of soil samples indicated a significant (80%) reduction in diesel concentrations

  14. Case studies in Bayesian microbial risk assessments

    Directory of Open Access Journals (Sweden)

    Turner Joanne

    2009-12-01

    Full Text Available Abstract Background The quantification of uncertainty and variability is a key component of quantitative risk analysis. Recent advances in Bayesian statistics make it ideal for integrating multiple sources of information, of different types and quality, and providing a realistic estimate of the combined uncertainty in the final risk estimates. Methods We present two case studies related to foodborne microbial risks. In the first, we combine models to describe the sequence of events resulting in illness from consumption of milk contaminated with VTEC O157. We used Monte Carlo simulation to propagate uncertainty in some of the inputs to computer models describing the farm and pasteurisation process. Resulting simulated contamination levels were then assigned to consumption events from a dietary survey. Finally we accounted for uncertainty in the dose-response relationship and uncertainty due to limited incidence data to derive uncertainty about yearly incidences of illness in young children. Options for altering the risk were considered by running the model with different hypothetical policy-driven exposure scenarios. In the second case study we illustrate an efficient Bayesian sensitivity analysis for identifying the most important parameters of a complex computer code that simulated VTEC O157 prevalence within a managed dairy herd. This was carried out in 2 stages, first to screen out the unimportant inputs, then to perform a more detailed analysis on the remaining inputs. The method works by building a Bayesian statistical approximation to the computer code using a number of known code input/output pairs (training runs. Results We estimated that the expected total number of children aged 1.5-4.5 who become ill due to VTEC O157 in milk is 8.6 per year, with 95% uncertainty interval (0,11.5. The most extreme policy we considered was banning on-farm pasteurisation of milk, which reduced the estimate to 6.4 with 95% interval (0,11. In the second

  15. Wind to Hydrogen in California: Case Study

    Energy Technology Data Exchange (ETDEWEB)

    Antonia, O.; Saur, G.

    2012-08-01

    This analysis presents a case study in California for a large scale, standalone wind electrolysis site. This is a techno-economic analysis of the 40,000 kg/day renewable production of hydrogen and subsequent delivery by truck to a fueling station in the Los Angeles area. This quantity of hydrogen represents about 1% vehicle market penetration for a city such as Los Angeles (assuming 0.62 kg/day/vehicle and 0.69 vehicles/person) [8]. A wind site near the Mojave Desert was selected for proximity to the LA area where hydrogen refueling stations are already built.

  16. Root gravitropism in maize and Arabidopsis

    Science.gov (United States)

    Evans, Michael L.

    1993-01-01

    Research during the period 1 March 1992 to 30 November 1993 focused on improvements in a video digitizer system designed to automate the recording of surface extension in plants responding to gravistimulation. The improvements included modification of software to allow detailed analysis of localized extension patterns in roots of Arabidopsis. We used the system to analyze the role of the postmitotic isodiametric growth zone (a region between the meristem and the elongation zone) in the response of maize roots to auxin, calcium, touch and gravity. We also used the system to analyze short-term auxin and gravitropic responses in mutants of Arabidopsis with reduced auxin sensitivity. In a related project, we studied the relationship between growth rate and surface electrical currents in roots by examining the effects of gravity and thigmostimulation on surface potentials in maize roots.

  17. Phosphorylation of plastoglobular proteins in Arabidopsis thaliana.

    Science.gov (United States)

    Lohscheider, Jens N; Friso, Giulia; van Wijk, Klaas J

    2016-06-01

    Plastoglobules (PGs) are plastid lipid-protein particles with a small specialized proteome and metabolome. Among the 30 core PG proteins are six proteins of the ancient ABC1 atypical kinase (ABC1K) family and their locations in an Arabidopsis mRNA-based co-expression network suggested central regulatory roles. To identify candidate ABC1K targets and a possible ABC1K hierarchical phosphorylation network within the chloroplast PG proteome, we searched Arabidopsis phosphoproteomics data from publicly available sources. Evaluation of underlying spectra and/or associated information was challenging for a variety of reasons, but supported pSer sites and a few pThr sites in nine PG proteins, including five FIBRILLINS. PG phosphorylation motifs are discussed in the context of possible responsible kinases. The challenges of collection and evaluation of published Arabidopsis phosphorylation data are discussed, illustrating the importance of deposition of all mass spectrometry data in well-organized repositories such as PRIDE and ProteomeXchange. This study provides a starting point for experimental testing of phosho-sites in PG proteins and also suggests that phosphoproteomics studies specifically designed toward the PG proteome and its ABC1K are needed to understand phosphorylation networks in these specialized particles. PMID:26962209

  18. The Effect of Using Case Studies in Business Statistics

    Science.gov (United States)

    Pariseau, Susan E.; Kezim, Boualem

    2007-01-01

    The authors evaluated the effect on learning of using case studies in business statistics courses. The authors divided students into 3 groups: a control group, a group that completed 1 case study, and a group that completed 3 case studies. Results evidenced that, on average, students whom the authors required to complete a case analysis received…

  19. Combining genetic association study designs: a GWAS case study

    OpenAIRE

    Estus, Janice L.; ,; Fardo, David W.

    2013-01-01

    Genome-wide association studies (GWAS) explore the relationship between genome variability and disease susceptibility with either population- or family-based data. Here, we have evaluated the utility of combining population- and family-based statistical association tests and have proposed a method for reducing the burden of multiple testing. Unrelated singleton and parent-offspring trio cases and controls from the Genetics of Kidneys in Diabetes (GoKinD) study were analyzed for genetic associ...

  20. Social Architecture: An Emergency Management Case Study

    Directory of Open Access Journals (Sweden)

    Asif Qumer Gill

    2015-03-01

    Full Text Available Emergency management agencies are progressively using social media for the sourcing and distribution of disaster information. Emergency management agencies are often unsure as to how to best identify and assess social media concerns (e.g. information security, trust which must be addressed to develop a social media-enabled disaster information management environment. This paper adopts the Social Architecture Viewpoint Assessment (SAVA framework for identifying and assessing social media concerns from four different viewpoints: IT, Value, Resource and Management. This paper demonstrates the use of the SAVA framework in the context of an in-depth empirical case study of an Australian emergency management agency. The results of this study indicate that the SAVA framework is useful for emergency information management managers in identifying and assessing social media concerns.

  1. Commercializing Emerging Renewable Energy: A Case Study

    Directory of Open Access Journals (Sweden)

    Matti Lehtovaara

    2012-12-01

    Full Text Available A broad scientific consensus exists that the global climate is changing. The Earth’s surface temperature could rise significantly over the next few decades, leading to us witnessing an entirely new and unknown planet. Improved energy efficiency, decreasing use of fossil fuels and wide diffusion of various renewable energy sources are among the focal measures to limit global warming to a sustainable level. The objective of this study is to analyse how renewable energy, such as wind power and bioenergy, could be efficiently commercialized. The evaluation is based on a case study and expert analyses exploiting lateral and parallel thinking methods, and group decision support systems tools. The results reveal that some of the generated ideas are ready for implementation to commercialize renewable energy, whereas others still require technical and commercial development and improvements before maturity.

  2. Numerical and structural chromosome aberrations in cauliflower (Brassica oleracea var. botrytis) and Arabidopsis thaliana

    OpenAIRE

    Ji, X.

    2014-01-01

    Numerical and structural chromosome aberrations in cauliflower (Brassica oleracea var. botrytis) and Arabidopsis thaliana. I studied numerical and structural chromosome aberrations in cauliflower (Brassica oleracea var. botrytis) and Arabidopsis thaliana. The large genomic changes are important for gene balance control, gene expression and regulation, and may affect the plant’s phenotype. Moreover, chromosome changes, in particular polyploidy, inversions and translocations play a signif...

  3. Transgenic Arabidopsis Gene Expression System

    Science.gov (United States)

    Ferl, Robert; Paul, Anna-Lisa

    2009-01-01

    The Transgenic Arabidopsis Gene Expression System (TAGES) investigation is one in a pair of investigations that use the Advanced Biological Research System (ABRS) facility. TAGES uses Arabidopsis thaliana, thale cress, with sensor promoter-reporter gene constructs that render the plants as biomonitors (an organism used to determine the quality of the surrounding environment) of their environment using real-time nondestructive Green Fluorescent Protein (GFP) imagery and traditional postflight analyses.

  4. Os Trigonum Syndrome: A Case Study

    Directory of Open Access Journals (Sweden)

    Yasemin Turan

    2013-05-01

    Full Text Available Os trigonum syndrome is one of the rare causes of posterior foot pain. Ostrigonum, which is placed at the posterior of talus, is an accessory bone. Ostrigonum syndrome causes back foot pain due to compression between talusand calcaneus. In this study, we present a case of os trigonum syndrome ,which is a rare disease and is generally missed. A 65-year-old female patientwith a complaint of left foot pain for the last 2 months persented to our outpatientclinic. In the physical examination, plantar flexion of the ankle andtoe was painful. Patient’s pain was evaluated by the visual analog scale andnoted as 8 cm. There was sensitivity at the posterior of talus during palpation.Os trigonum syndrome was diagnosed based on radiological examinationsand a physical therapy program consisting of transcutaneous electrical nervestimulation (TENS, cold pack, foot and ankle range of motion and strengtheningexercises was started. After the treatment, pain VAS decreased to 2cm,and then the patient was followed clinically. As in our case, os trigonum syndromeshould also be taken into consideration in patients complaining withposterior foot pain apart from other frequently encountered causes. In suchcases, physical therapy programs are very effective in pain management andin reducing the cost of treatment. Turk J Phys Med Rehab 2013;59:161-4.

  5. Building Energy Information Systems: User Case Studies

    Energy Technology Data Exchange (ETDEWEB)

    Granderson, Jessica; Piette, Mary Ann; Ghatikar, Girish

    2010-03-22

    Measured energy performance data are essential to national efforts to improve building efficiency, as evidenced in recent benchmarking mandates, and in a growing body of work that indicates the value of permanent monitoring and energy information feedback. This paper presents case studies of energy information systems (EIS) at four enterprises and university campuses, focusing on the attained energy savings, and successes and challenges in technology use and integration. EIS are broadly defined as performance monitoring software, data acquisition hardware, and communication systems to store, analyze and display building energy information. Case investigations showed that the most common energy savings and instances of waste concerned scheduling errors, measurement and verification, and inefficient operations. Data quality is critical to effective EIS use, and is most challenging at the subsystem or component level, and with non-electric energy sources. Sophisticated prediction algorithms may not be well understood but can be applied quite effectively, and sites with custom benchmark models or metrics are more likely to perform analyses external to the EIS. Finally, resources and staffing were identified as a universal challenge, indicating a need to identify additional models of EIS use that extend beyond exclusive in-house use, to analysis services.

  6. Building energy information systems. User case studies

    Energy Technology Data Exchange (ETDEWEB)

    Granderson, J.; Piette, M.A.; Ghatikar, G. [Lawrence Berkeley, National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States)

    2011-01-15

    Measured energy performance data are essential to national efforts to improve building efficiency, as evidenced in recent benchmarking mandates, and in a growing body of work that indicates the value of permanent monitoring and energy information feedback. This paper presents case studies of energy information systems (EIS) at four enterprises and university campuses, focusing on the attained energy savings, and successes and challenges in technology use and integration. EIS are broadly defined as performance monitoring software, data acquisition hardware, and communication systems to store, analyze, and display building energy information. Case investigations showed that the most common energy savings and instances of waste concerned scheduling errors, measurement and verification, and inefficient operations. Data quality is critical to effective EIS use, and is most challenging at the subsystem or component level, and with non-electric energy sources. Sophisticated prediction algorithms may not be well understood but can be applied quite effectively, and sites with custom benchmark models or metrics are more likely to perform analyses external to the EIS. Finally, resources and staffing were identified as a universal challenge, indicating a need to identify additional models of EIS use that extend beyond exclusive in-house use, to analysis services.

  7. Use of the foot-and-mouth disease virus 2A peptide co-expression system to study intracellular protein trafficking in Arabidopsis.

    Directory of Open Access Journals (Sweden)

    Stefan Burén

    Full Text Available BACKGROUND: A tool for stoichiometric co-expression of effector and target proteins to study intracellular protein trafficking processes has been provided by the so called 2A peptide technology. In this system, the 16-20 amino acid 2A peptide from RNA viruses allows synthesis of multiple gene products from single transcripts. However, so far the use of the 2A technology in plant systems has been limited. METHODOLOGY/PRINCIPAL FINDINGS: The aim of this work was to assess the suitability of the 2A peptide technology to study the effects exerted by dominant mutant forms of three small GTPase proteins, RABD2a, SAR1, and ARF1 on intracellular protein trafficking in plant cells. Special emphasis was given to CAH1 protein from Arabidopsis, which is trafficking to the chloroplast via a poorly characterized endoplasmic reticulum-to-Golgi pathway. Dominant negative mutants for these GTPases were co-expressed with fluorescent marker proteins as polyproteins separated by a 20 residue self-cleaving 2A peptide. Cleavage efficiency analysis of the generated polyproteins showed that functionality of the 2A peptide was influenced by several factors. This enabled us to design constructs with greatly increased cleavage efficiency compared to previous studies. The dominant negative GTPase variants resulting from cleavage of these 2A peptide constructs were found to be stable and active, and were successfully used to study the inhibitory effect on trafficking of the N-glycosylated CAH1 protein through the endomembrane system. CONCLUSIONS/SIGNIFICANCE: We demonstrate that the 2A peptide is a suitable tool when studying plant intracellular protein trafficking and that transient protoplast and in planta expression of mutant forms of SAR1 and RABD2a disrupts CAH1 trafficking. Similarly, expression of dominant ARF1 mutants also caused inhibition of CAH1 trafficking to a different extent. These results indicate that early trafficking of the plastid glycoprotein CAH1

  8. A multifaceted study of stigma/style cysteine-rich adhesin (SCA)-like Arabidopsis lipid transfer proteins (LTPs) suggests diversified roles for these LTPs in plant growth and reproduction

    OpenAIRE

    Chae, Keun; Gonong, Benedict J.; Kim, Seung-Chul; Kieslich, Chris A.; Morikis, Dimitrios; Balasubramanian, Shruthi; Lord, Elizabeth M

    2010-01-01

    Lily stigma/style cysteine-rich adhesin (SCA), a plant lipid transfer protein (LTP) which is secreted into the extracellular matrix, functions in pollen tube guidance in fertilization. A gain-of-function mutant (ltp5-1) for Arabidopsis LTP5, an SCA-like molecule, was recently shown to display defects in sexual reproduction. In the current study, it is reported that ltp5-1 plants have dwarfed primary shoots, delayed hypocotyl elongation, various abnormal tissue fusions, and display multibranch...

  9. Study on Case-Based Fixture Design

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Fixture is an important manufacturing activity. A fixture design system based on case-based reasoning (CBR) is proposed in this paper. A new method of case representation on the basis of fixture function is presented, where the case representation is constituted of workpiece knowledge, processing feature knowledge, and fixture feature knowledge. Running the prototype system shows that the knowledge representation method, using cases, is a better way to transform and explain the design knowledge.

  10. Logistics opportunity costs: A mining case study

    Directory of Open Access Journals (Sweden)

    Leani van Jaarsveld

    2013-05-01

    Full Text Available This study highlighted the importance of determining the impact that an ineffective mode of transport has on a firm’s transportation model and costs. The main focus of this study was to determine the logistics opportunity costs of using road transport within a mining firm. A case study approach was followed, as the investigation aimed to analyse a complex problem experienced by one company and present it in an easily understandable format. From the results of this study, it was apparent that the logistics opportunity costs associated with the mode of transport was substantial. This highlighted the need for firms to revise their choice of transport mode on a regular basis, as it has a major impact not only on their transportation costs, but also on their inventory holding and carbon emissions. The results also have implications for South Africa’s only freight railway, Transnet Freight Rail, which should not only focus on expanding its existing capacity, but also on improving its customer service delivery whilst containing tariff increases.

  11. Obsessional Slowness in College Students: Case Studies

    Science.gov (United States)

    Johnson, Aleta

    2014-01-01

    Cases of obsessional slowness, a variant of obsessive compulsive disorder, have been documented in case literature regarding relatively low functioning populations. However, obsessional slowness can also present in higher functioning populations, including college and graduate students, as illustrated here by three case examples from a competitive…

  12. Unraveling phonological conspiracies: A case study.

    Science.gov (United States)

    Dinnsen, Daniel A; Gierut, Judith A; Morrisette, Michele L; Rose, Darcy E

    2014-01-01

    This paper focuses on three seemingly unrelated error patterns in the sound system of a child with a phonological delay, Child 218 (male, age 4 years 6 months) and ascribes those error patterns to a larger conspiracy to eliminate fricatives from the phonetic inventory. Employing Optimality Theory for its advantages in characterizing conspiracies, our analysis offers a unified account of the observed repairs. The contextual restrictions on those repairs are, moreover, attributed to early developmental prominence effects, which are independently manifested in another error pattern involving rhotic consonants. Comparisons are made with a published case study involving a different implementation of the same conspiracy, the intent being to disambiguate the force behind certain error patterns. The clinical implications of the account are also considered. PMID:25000372

  13. Telepractice for pediatric Dysphagia: a case study.

    Science.gov (United States)

    Malandraki, Georgia A; Roth, Melissa; Sheppard, Justine Joan

    2014-01-01

    A closed-ended intensive pediatric swallowing telepractice program was developed and piloted in one pediatric patient with Opitz BBB/G and Asperger's Syndromes, oropharyngeal dysphagia and aerophagia. The present study is a case report. Outcome variables included behavioral, swallowing and quality of life variables, and were assessed at baseline and at the end of the four-week program. Selective variables were also assessed at a follow-up family interview four weeks post program completion. Over the four-week intervention period, the patient demonstrated substantial improvements in: oral acceptance of eating-related objects and a variety of foods (behavioral variable), timing of voluntary saliva swallows and aerophagia levels (swallowing variables) and quality of life. Follow-up interview analysis showed that most skills were retained or improved one-month post intervention. This intensive telepractice program proved to be feasible and effective for this pediatric patient with dysphagia. PMID:25945217

  14. Telepractice for Pediatric Dysphagia: A Case Study

    Directory of Open Access Journals (Sweden)

    Georgia A. Malandraki

    2014-09-01

    Full Text Available A closed-ended intensive pediatric swallowing telepractice program was developed and piloted in one pediatric patient with Opitz BBB/G and Asperger’s Syndromes, oropharyngeal dysphagia and aerophagia. The present study is a case report. Outcome variables included behavioral, swallowing and quality of life variables, and were assessed at baseline and at the end of the four-week program. Selective variables were also assessed at a follow-up family interview four weeks post program completion. Over the four-week intervention period, the patient demonstrated substantial improvements in: oral acceptance of eating-related objects and a variety of foods (behavioral variable, timing of voluntary saliva swallows and aerophagia levels (swallowing variables and quality of life. Follow-up interview analysis showed that most skills were retained or improved one-month post intervention. This intensive telepractice program proved to be feasible and effective for this pediatric patient with dysphagia.

  15. Understanding Support - lessons from a case study

    Directory of Open Access Journals (Sweden)

    Chris Sauer

    1993-11-01

    Full Text Available Support from top management and others is agreed to be an important factor in information systems success and failure, but little is written about how it has its effect and how it might be managed to a project's advantage. A recently developed conceptual framework is described. It covers the nature and forms of support, the way support affects project outcomes, the bases on which support is provided, and the strategies by which support may be managed. The framework is used to analyse a case study in several stages. At the end of the analysis of each stage, the framework's utility is assessed in terms of its explanatory value and the practical advice it suggests. Areas for further research are identified.

  16. Unmasking Cleckley's psychopath: assessing historical case studies.

    Science.gov (United States)

    DeShong, Hilary L; Helle, Ashley C; Mullins-Sweatt, Stephanie N

    2016-05-01

    The current study investigated original case descriptions of psychopathy (Cleckley, 1941) in relation to current conceptualizations and general personality traits. Attorneys, forensic psychologists and clinical faculty members completed ratings of psychopathy and personality after reading vignettes based on Cleckley's descriptions of a psychopath. The results suggest that professionals' ratings are consistent with current conceptualizations of psychopathy. Furthermore, the five-factor model (FFM) personality traits of the vignettes aligned with the current literature on the FFM and psychopathy (i.e. low neuroticism, conscientiousness and agreeableness). The results further supported that a general trait model, like the FFM, may be well suited to describe the underlying personality traits of psychopathy. Gender differences were also examined. PMID:26931520

  17. Case studies of attacks on communication networks

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Sin Bok; Han, Eon Suk [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1996-06-15

    Recently, as the computer hardware and communications are developed, the data exchange through inter-networking has been highlighted and the data is being recognized as a great asset. Most of the organizations, businesses and enterprises are open to the external world-computer communication networks, attention must be focused on the securities of the information infrastructure. A government organization has been developing 'Circuits Analyzers', and 'Hacker-Tracking Program' and is struggling to track down sneakers. In this report, we analyze the contents of the cases where the communication network has been invaded, from the past up until now in Korea. This report also contains the result of a study on E-mail security, for the protection of KAERI Integrated Management Information System under which utilizes the CALS concepts and web services. (Author)

  18. The virtual information: a case study

    Directory of Open Access Journals (Sweden)

    Ginevra Gravili

    2012-09-01

    Full Text Available In todays economics, the fact that information is a major factor of production and of increasing importance as a source of competitive advantage is a generally accepted truism. The trend towards global markets has strongly impacted the competitive situation of many enterprises. Never has the economic environment been subject to so many drastic and rapid changes. This put new weight factors on the requirements for design of business process. This paper explores the case of an Italian legal office that has studied more and more innovative solutions both to satisfy the demands of the clienteles and to oppose the action of the new competitors. Comparing classic models and the theories of Porter with the characteristics and needs of new economy, it shows as the ability to possess, to easily have access, to creatively use of information constitutes one of the more strategic sources of the competitive advantage.

  19. Automated cardiopulmonary resuscitation: a case study.

    Science.gov (United States)

    Spiro, Jon; Theodosiou, Maria; Doshi, Sagar

    2014-02-01

    Rates of survival after cardiac arrest are low and correlate with the quality of cardiopulmonary resuscitation (CPR). Devices that deliver automated CPR (A-CPR) can provide sustained and effective chest compressions, which are especially useful during patient transfer and while simultaneous invasive procedures are being performed. The use of such devices can also release members of resuscitation teams for other work. This article presents a case study involving a man with acute myocardial infarction complicated by cardiogenic shock and pulmonary oedema. It describes how ED nursing and medical teams worked together to deliver A-CPR, discusses the use of A-CPR devices in a tertiary cardiac centre, and highlights the advantages of using such devices. PMID:24494769

  20. Robust control systems theory and case studies

    CERN Document Server

    Mackenroth, Uwe

    2004-01-01

    "Robust Control Systems" gives a self-contained introduction to modern Control Theory. It thus adds a textbook to the existing research-oriented literature on Robust Control. The author lays emphasis on the modern aspects of the design of controllers with prescribed performance and robustness properties. Different to the classical engineering approach, a rigorous mathematical treatment is essential for the full understanding and applicability of the modern methods such as H2 or H8 control or methods based on the structured singular value µ. Nevertheless, no prior knowledge of Control Theory is required as the classical fundamentals are introduced within the first few chapters. Subsequently a large part of the text provides elementary examples and industrial case studies, which are developed in full detail to show how modern methods can be applied to advanced problems. They make intensive use of MATLAB, especially the Control Systems Toolbox and the µ-Analysis and Synthesis Toolbox.

  1. Case studies of attacks on communication networks

    International Nuclear Information System (INIS)

    Recently, as the computer hardware and communications are developed, the data exchange through inter-networking has been highlighted and the data is being recognized as a great asset. Most of the organizations, businesses and enterprises are open to the external world-computer communication networks, attention must be focused on the securities of the information infrastructure. A government organization has been developing 'Circuits Analyzers', and 'Hacker-Tracking Program' and is struggling to track down sneakers. In this report, we analyze the contents of the cases where the communication network has been invaded, from the past up until now in Korea. This report also contains the result of a study on E-mail security, for the protection of KAERI Integrated Management Information System under which utilizes the CALS concepts and web services. (Author)

  2. Studies on Differential Nuclear Translocation Mechanism and Assembly of the Three Subunits of the Arabidopsis thaliana Transcription Factor NF-Y

    Institute of Scientific and Technical Information of China (English)

    Dieter Hackenberg; Yanfang Wu; Andrea Voigt; Robert Adams; Peter Schramm; Bernhard Grimm

    2012-01-01

    The eukaryotic transcription factor NF-Y consists of three subunits(A,B,and C),which are encoded in Arabidopsis thaliana in multigene families consisting of 10,13,and 13 genes,respectively.In principle,all potential combinations of the subunits are possible for the assembly of the heterotrimeric complex.We aimed at assessing the probability of each subunit to participate in the assembly of NF-Y.The evaluation of physical interactions among all members of the NF-Y subunit families indicate a strong requirement for NF-YB/NF-YC heterodimerization before the entire complex can be accomplished.By means of a modified yeast two-hybrid system assembly of all three subunits to a heterotrimeric complex was demonstrated.Using GFP fusion constructs,NF-YA and NF-YC localization in the nucleus was demonstrated,while NFYB is solely imported into the nucleus as a NF-YC-associated heterodimer NF-YC.This piggyback transport of the two Arabidopsis subunits differs from the import of the NF-Y heterotrimer of heterotrophic organisms.Based on a peptide structure model of the histone-fold-motifs,disulfide bonding among intramolecular conserved cysteine residues of NF-YB,which is responsible for the redox-regulated assembly of NF-YB and NF-YC in human and Aspergillus nidulans,can be excluded for Arabidopsis NF-YB.

  3. Landslide Economics: Concepts and Case Studies

    Science.gov (United States)

    Klose, Martin; Damm, Bodo

    2015-04-01

    Landslide economics is vital for fundamental understanding of landslide risk as dealing with two important topics: (i) impact assessment, either as damage statistics or cost modeling, and (ii) vulnerability assessment, i.e., the study of exposure, sensitivity, and resilience to landslide damage, ideally from both sociotechnical and financial perspective (e.g., Crovelli and Coe, 2009; Wills et al., 2014). Many aspects addressed in landslide economics have direct influence on landslide risk, including: (i) human activity is often a major causative factor of landslides, not only by predisposing or triggering them, but also as a result of inadequate (low-cost) landslide mitigation; (ii) the level of tolerable or acceptable risk, a measure driving a large part of landslide costs in industrialized countries, is highly variable, differing between individuals, public or private organizations, and societies, with its nature being to change over time; and (iii) decision makers are faced with finding the right balance in landslide mitigation, thus need to weight diverse geological and socioeconomic factors that control its effectiveness in both technical and financial terms (e.g., Klose et al., 2014a). A large part of the complexity in assessing landslide risk as measured by economic costs is due to unique problems in understanding of (i) what types of landslide damage affect human activity and infrastructure in which way, (ii) how society contributes and responds to various kinds of damage, and (iii) how landslide damage is valued in monetary terms. Landslide economics shows the potential to take account of these sociocultural factors to the benefit of risk analysis (e.g., Klose et al., 2014b). The present contribution introduces local and regional case studies in which different economic issues of landslide risk are highlighted using the example of public infrastructures in NW Germany. A special focus is on the following topics: (i) risk culture and created risk, (ii

  4. Industrialization: Different Approaches and Case Studies Industrialization: Different Approaches and Case Studies

    OpenAIRE

    Keith Griffin

    1987-01-01

    Industrialization: Different Approaches and Case Studies This paper enquires whether an industrialisation policy designed by the state might be successful in achieving industrialisation and development in the third world. Three common approaches to industrialisation are analysed in terms of their structural features and consequences: import substitution, capital goods sector promotion, and manufacturing export promotion. Associating these strategies to Brazil, India and South Korea, respectiv...

  5. Case studies on age-management in organisations: report on organisational case studies

    NARCIS (Netherlands)

    Punte, E.; Conen, W.S.; Schippers, J.; Henkens, C.J.I.M.

    2011-01-01

    The acquisition of case studies was thwarted by the economic crisis and the feeling of being ‘over-researched’ by potential organisations. Although organisations in some sectors (e.g. chemical manufacturing) reported the worst part of the economic crisis was behind, many organisations indicated gett

  6. Case Study: The Mystery of the Seven Deaths--A Case Study in Cellular Respiration

    Science.gov (United States)

    Gazdik, Michaela

    2014-01-01

    Cellular respiration, the central component of cellular metabolism, can be a difficult concept for many students to fully understand. In this interrupted, problem-based case study, students explore the purpose of cellular respiration as they play the role of medical examiner, analyzing autopsy evidence to determine the mysterious cause of death…

  7. Antineutrino reactor safeguards - a case study

    CERN Document Server

    Christensen, Eric; Jaffke, Patrick

    2013-01-01

    Antineutrinos have been proposed as a means of reactor safeguards for more than 30 years and there has been impressive experimental progress in neutrino detection. In this paper we conduct, for the first time, a case study of the application of antineutrino safeguards to a real-world scenario - the North Korean nuclear crisis in 1994. We derive detection limits to a partial or full core discharge in 1989 based on actual IAEA safeguards access and find that two independent methods would have yielded positive evidence for a second core with very high confidence. To generalize our results, we provide detailed estimates for the sensitivity to the plutonium content of various types of reactors, including most types of plutonium production reactors, based on detailed reactor simulations. A key finding of this study is that a wide class of reactors with a thermal power of less than 0.1-1 GWth can be safeguarded achieving IAEA goals for quantitative sensitivity and timeliness with detectors right outside the reactor ...

  8. Odontoma: a retrospective study of 73 cases

    Energy Technology Data Exchange (ETDEWEB)

    An, Seo Young; An, Chang Hyeon; Choi, Karp Shik [School of Dentistry, Kyungpook National University, Daegu (Korea, Republic of)

    2012-06-15

    The purpose of the present study was to retrospectively evaluate the clinical findings and treatment results for impacted permanent teeth associated with odontomas. We retrospectively investigated 73 odontomas in 72 patients who visited Kyungpook National University Dental Hospital from April 2004 through November 2011. The study was performed using medical records, panoramic radiographs, and pathological reports. Data gathered included age, gender, location, chief complaints, effects on dentition, and treatment of odontoma and the impacted tooth associated with odontoma. Most compound odontomas (46.7%) were found in the second decade and complex odontomas were not related to age. Odontomas showed no gender predilection. Fifty-five cases (75.3%) of odontomas were detected on routine dental radiographs. Sixty percent of compound odontomas occurred in the canine area and 57.1% of complex odontomas in the molar areas. Impaction of permanent teeth (61.6%) was the most common complication on the adjacent teeth. Most odontomas (84.9%) were removed surgically and impacted permanent teeth were managed by surgical removal (53.2%), orthodontic treatment (25.5%), or surgical repositioning (6.4%). There was a statistically significant relation between age and preservation of the impacted permanent teeth associated with odontomas (p<0.01). Early detection and treatment of odontomas increase the possibility of preservation of the impacted tooth. Therefore, it would be suggested that periodic panoramic examination during the first and second decade of life might be beneficial for the early detection and better prognosis of odontomas.

  9. Tactile Astronomy - a Portuguese case study

    Science.gov (United States)

    Canas, L.; Alves, F.; Correia, A.

    2012-09-01

    Although astronomy plays an important role in the most various outreach initiatives, as well as school science curricula, due to its strong visual component in knowledge acquisition, astronomy subjects are not entirely well addressed and accessed by visually impaired students and/or general public. This stresses the need of more tactile material production, still very scarce in an educational context whether formal or informal. This is a case study activity developed based on different schematic tactile images of several objects present in our solar system. These images in relief, highlight, through touch, several relevant features present in the different astronomical objects studied. The scientific knowledge is apprehended through the use of a tactile key, complemented with additional information. Through proper hands-on activities implementation and careful analysis of the outcome, the adapted images associated with an explanatory key prove to be a valuable resource in tactile astronomy domain. Here we describe the process of implementing such initiative near visually impaired students. The struggles and challenges perceived by all involved and the enrichment experience of engaging astronomy with visually impaired audiences, broadening horizons in an overall experience accessible to all.

  10. Odontoma: a retrospective study of 73 cases

    International Nuclear Information System (INIS)

    The purpose of the present study was to retrospectively evaluate the clinical findings and treatment results for impacted permanent teeth associated with odontomas. We retrospectively investigated 73 odontomas in 72 patients who visited Kyungpook National University Dental Hospital from April 2004 through November 2011. The study was performed using medical records, panoramic radiographs, and pathological reports. Data gathered included age, gender, location, chief complaints, effects on dentition, and treatment of odontoma and the impacted tooth associated with odontoma. Most compound odontomas (46.7%) were found in the second decade and complex odontomas were not related to age. Odontomas showed no gender predilection. Fifty-five cases (75.3%) of odontomas were detected on routine dental radiographs. Sixty percent of compound odontomas occurred in the canine area and 57.1% of complex odontomas in the molar areas. Impaction of permanent teeth (61.6%) was the most common complication on the adjacent teeth. Most odontomas (84.9%) were removed surgically and impacted permanent teeth were managed by surgical removal (53.2%), orthodontic treatment (25.5%), or surgical repositioning (6.4%). There was a statistically significant relation between age and preservation of the impacted permanent teeth associated with odontomas (p<0.01). Early detection and treatment of odontomas increase the possibility of preservation of the impacted tooth. Therefore, it would be suggested that periodic panoramic examination during the first and second decade of life might be beneficial for the early detection and better prognosis of odontomas.

  11. Anorexia in the Adolescence - case study

    Directory of Open Access Journals (Sweden)

    Almeida de Paiva, Maria O

    2010-07-01

    Full Text Available Eating disorders lead to special biological and psychological states. The result of the total lack of food is treated in a distinct way by anorexia. Nutritionists have thus had difficulty in coming to an agreement on the best therapy to prevent such disorders. First it is essential to understand which treatment aims are and then to attempt to know how the several treatment models used nowadays can reach those aims. Someone who suffers from eating disorders, together with an inner deformation, suffers from too much sensitiveness. In order to solve these problems, one needs a change in the relationship with oneself, with the others and with the world. This study presents a teenager’s case study – Anorexia. Is, in fact, a problem that society faces and can’t ignore. Many youngsters have already died and others are following their steps. But there are also those ones that succeeded in overcoming the problem and now are reporting their stories.

  12. BOOK REVIEW: Case Studies in Knowledge Management

    Directory of Open Access Journals (Sweden)

    Reviewed by Dr. Adnan BOYACI

    2005-10-01

    Full Text Available 161Case Studies in Knowledge ManagementEdited by Murray JennexHersley: PA: Idea Group, 2005, pp. 372, ISBN 1-59140-352-9Reviewed by Dr. Adnan BOYACIAnadolu UniversityEskişehir-TurkeyKnowledge management (KM as a structured system and the way to the effectiveness isrelatively new field for the contemporary organizations functioning in different andcompetitive domain of public and private sectors in terms of getting optimal effectivenessunderlined by the concepts such as quality, productivity…etc. Because of the growingimportance and the popularity of the KM either as a research topic or specialized coursesubject, a crucial need for understanding, conceptualization and implementation of KM asa system has emerged since the mid 1990’s. In this sense, the book contributes criticallyto fill the gap between theory and implementation as a teaching material.This edited book is published by Idea Group Publishing. The book has twenty chaptersdivided into seven sections. In addition to a section of authors’ biography contributing thebook and an index, there is a preface that the basic terms and key concepts underliningthe cases discussed following chapters, which is explained in a schematized way.Besides the editor, total of 47 authors have contributed to the book. These authors arefrom different countries, academic backgrounds, and institutions. Although approximatelyone third of the authors are from USA, the rest of the authors are from Canada, England,Austria, Germany, Australia, New Zealand, Egypt, Bahrain and China. The authorsrepresent a variety of universities, private companies, and military institutions. Most ofthem have strong professional backgrounds, which help them address the issues bothfrom theoretical and practical perspectives. Contributions of authors having differentbackgrounds and institutions enable the book to have very comprehensive spectrum andthis makes the book attractive practically for those working different sectors

  13. Guidelines for Conducting Positivist Case Study Research in Information Systems

    Directory of Open Access Journals (Sweden)

    Graeme Shanks

    2002-11-01

    Full Text Available The case study research approach is widely used in a number of different ways within the information systems community. This paper focuses on positivist, deductive case study research in information systems. It provides clear definitions of important concepts in positivist case study research and illustrates these with an example research study. A critical analysis of the conduct and outcomes of two recently published positivist case studies is reported. One is a multiple case study that validated concepts in a framework for viewpoint development in requirements definition. The other is a single case study that examined the role of social enablers in enterprise resource planning systems implementation. A number of guidelines for successfully undertaking positivist case study research are identified including developing a clear understanding of key concepts and assumptions within the positivist paradigm; providing clear and unambiguous definitions of the units and interactions when using any theory; carefully defining the boundary of the theory used in the case study; using hypotheses rather than propositions in the empirical testing of theory; using fuzzy or probabilistic propositions in recognising that reality can never be perfectly known; selecting case studies carefully, particularly single case studies; and recognising that generalisation from positivist, single case studies is inherently different from generalisation from single experiments. When properly undertaken, positivist, deductive case study research is a valuable research approach for information systems researchers, particularly when used within pluralist research programs that use a number of different research approaches from different paradigms.

  14. Quantifying Wetland Functions: A Case Study

    Science.gov (United States)

    Potter, K. W.; Rogers, J. S.; Hoffman, A. R.; Wu, C.; Hoopes, J. A.; Armstrong, D. E.

    2007-05-01

    Wetlands are reputed to reduce peak flows and improve water quality by trapping sediment and phosphorus. However, there are relatively few studies that quantify these wetland functions. This paper reports on a study of a 45-hectare wetland in southern Wisconsin. The wetland is traversed by a stream channel that drains a predominantly agricultural 17.4 km2 watershed. During the spring and summer of 2006, we collected stage data and water samples at stations upstream and downstream of the wetland, with the former accounting for 82% of the contributing area. Continuous measurements of water stage at these stations were used to construct a streamflow record. During storm events water samples were taken automatically at 2-hour intervals for the first 12 samples and 8-hour intervals for the next 12 samples. Samples were analyzed for total suspended solids, total phosphorus, and dissolved reactive phosphorus. Ten events were observed during the observation period; the two largest events were 1 to 2-year storms. One-dimensional unsteady flow routing was used to estimate the maximum extent of wetland inundation for each event. When normalized for flow volume, all peak flows were attenuated by the wetland, with the maximum attenuation corresponding to the intermediate events. The reduced attenuation of the larger events appears to be due to filling of storage, either due to antecedent conditions or the event itself. In the case of sediment, the amount leaving the wetland in the two largest storms, which accounted for 96% of the exported sediment during the period of observation, was twice the amount entering the wetland. The failure of the wetland to trap sediment is apparently due to the role of drainage ditches, which trap sediment during the wetland-filling phase and release it during drainage. The export of sediment during the largest events appears to result from remobilization of sediment deposited in the low-gradient stream channel during smaller events. This

  15. Chromosomal rearrangement in autotetraploid plants of Arabidopsis thaliana.

    Science.gov (United States)

    Weiss, H; Maluszynska, J

    2000-01-01

    Recent development of cytogenetic techniques has facilitated significant progress in Arabidopsis thaliana karyotype studies. Double-target FISH with rRNA genes provides makers that allow individual chromosome in the genome to be distinguished. Those studies have revealed that the number and position of rDNA loci is ecotype-specific. Arabidopsis is believed to be a true diploid (x = 5) with numerous ecotypes (accessions) and only a very few natural polyploid populations reported. Few studies were undertaken to induce polyploidy in Arabidopsis, however none of those gave the cytogenetic characteristics of polyploid plants. Our analysis of chromosome pairing of colchicine-induced autotetraploid Arabidopsis (Wilna ecotype) revealed preferential bivalent pairing in PMCs (pollen mother cells). In order to attempt to explain this phenomenon, first of all more detailed cytogenetic studies of autopolyploid plants have been undertaken. The localization of 45S and 5S rDNA loci in the diploid and autotetraploid plants revealed that Wilna ecotypes belongs to the group of Arabidopsis accessions with only two 5S rDNA loci present in a genome. Furthermore, the rearrangement of 45S rDNA locus in autopolyploid, when compared to the diploid plants of the same ecotype, was revealed. These results are interesting also in the context of the recently emphasised role of polyploidy in plant evolution and speciation. Arabidopsis, despite having small chromosomes, is a good system to study chromosome behaviour in relation to diploidization of autopolyploids and to evaluate the degree of chromosomal rearrangements during this process. PMID:11433970

  16. Integrative study of Arabidopsis thaliana metabolomic and transcriptomic data with the interactive MarVis-Graph software

    OpenAIRE

    Manuel Landesfeind; Alexander Kaever; Kirstin Feussner; Corinna Thurow; Christiane Gatz; Ivo Feussner; Peter Meinicke

    2014-01-01

    State of the art high-throughput technologies allow comprehensive experimental studies of organism metabolism and induce the need for a convenient presentation of large heterogeneous datasets. Especially, the combined analysis and visualization of data from different high-throughput technologies remains a key challenge in bioinformatics. We present here the MarVis-Graph software for integrative analysis of metabolic and transcriptomic data. All experimental data is investigated in terms of th...

  17. Case Study: Camptocormia, a Rare Conversion Disorder.

    Science.gov (United States)

    Rajmohan, Velayudhan; Thomas, Biju; Sreekumar, Kumaran

    2004-01-01

    Camptocormia is a condition characterized by severe frontal flexion of the spinal cord and knees, with passive drooping of both arms. It occurs as a form of conversion disorder. Some cases are associated with behavioral problems. A case of camptocormia of 2-year duration in a south Indian adolescent girl with oppositional defiant disorder and…

  18. Case Study Research in Software Engineering Guidelines and Examples

    CERN Document Server

    Runeson, Per; Rainer, Austen; Regnell, Bjorn

    2012-01-01

    Based on their own experiences of in-depth case studies of software projects in international corporations, in this book the authors present detailed practical guidelines on the preparation, conduct, design and reporting of case studies of software engineering.  This is the first software engineering specific book on the case study research method.

  19. STUDY OF MATERNAL AND PERINATAL OUTCOME IN REFERRED OBSTETRICS CASES

    OpenAIRE

    Umesh; Alka Murlidhar

    2015-01-01

    OBJECTIVE: To review the referred obstetric cases for reason of referral and to study the maternal and perinatal outcome. DESIGN: Prospective Observational study . STUDY POPULATION: 380 cases referred from periphery to tertiary care institute in one year duration. METHODS: INCLUSION C RITERIA : All referred ANC cases to our tertiary care i...

  20. Jazz improvisers’ shared understanding: A case study

    Directory of Open Access Journals (Sweden)

    Michael F. Schober

    2014-08-01

    Full Text Available To what extent and in what arenas do collaborating musicians need to understand what they are doing in the same way? Two experienced jazz musicians who had never previously played together played three improvisations on a jazz standard (It Could Happen to You on either side of a visual barrier. They were then immediately interviewed separately about the performances, their musical intentions, and their judgments of their partner’s musical intentions, both from memory and prompted with the audiorecordings of the performances. Statements from both (audiorecorded interviews as well as statements from an expert listener were extracted and anonymized. Two months later, the performers listened to the recordings and rated the extent to which they endorsed each statement. Performers endorsed statements they themselves had generated more often than statements by their performing partner and the expert listener; their overall level of agreement with each other was greater than chance but moderate to low, with disagreements about the quality of one of the performances and about who was responsible for it. The quality of the performances combined with the disparities in agreement suggest that, at least in this case study, fully shared understanding of what happened is not essential for successful improvisation. The fact that the performers endorsed an expert listener’s statements more than their partner’s argues against a simple notion that performers’ interpretations are always privileged relative to an outsider’s.

  1. Environmental injustice: case studies from the South

    Science.gov (United States)

    Cifuentes, Enrique; Frumkin, Howard

    2007-10-01

    We selected three case studies to illustrate environmental injustice issues in the South. These examples relate to migrant agricultural workers, the maquiladora industry and artisanal mining, while reviewing some of the major mechanisms involved, e.g. multinational corporations, the development of free trade zones, multilateral free trade agreements and the export of hazards. A series of strategies are discussed in order to address environmental injustice and health disparities that exist on a global scale. Some of the recommendations involve policy initiatives; others, such as research and mentorship, fall within the traditional domain of public health practice. In this paper, special attention is given to concerned environmental and occupational health professionals using evidence-based data for advocacy. For lasting changes to be made, however, stronger institutions and legislation are required. Those who have the 'right to know' about environmental injustice issues include communities of concern, workers' representatives and lawyers. Government officials and company officials may eventually work on the basis of conflict resolution, compensation and remediation, to quote some examples. Systematic approaches to protect both the environment and public health must be updated.

  2. VINCRISTINE INDUCED NEUROTOXICITY: STUDY OF 75 CASES

    Directory of Open Access Journals (Sweden)

    M.T. Arzanian

    2009-08-01

    Full Text Available ObjectiveConcern for side-effects of therapy related to treatment of childhood malignancies is becoming an increasingly important topic. In this study, we evaluated extent of vincristine (VCR induced neurotoxicity in a group of children who underwent chemotherapy, with VCR being part of the regimen.Materials & MethodsIn this investigation, for 75 children (54% boys, 46% girls, aged between 1 to 14 (mean 6.5±4.3 years, serial weekly neurological examinations were performed; of the 75, 70 had acute lymphoblastic leukemia and 5 Wilm's tumor. All patients were on a chemotherapy protocol of at least 4 consecutive VCR (1.5mg/m2 injections.ResultsDecreased deep tendons reflexes were seen in the Achilles reflex in 78%, and the patellar reflex in 53% of patients. Muscle weakness was found in 70% of patients, being mild in 76% of them. Four  percent of patients showed severe weakness. Petosis, jaw pain, hoarseness, abdominal pain and constipation were seen in 15%, 6%, 12%, 12% and 12% respectively. Paresthesia was observed in 32 of 52 patients, over 4 years old. No cases of foot drop, urinary retention or facial nerve palsy were seen in this patient group.ConclusionChildren on usual doses of vincristine regimen may have neuropathic side effects but most of these side effects are mild and not troublesome.Key words: Vincristine, neuropathy, neurotoxicity, side effect

  3. High Penetration Photovoltaic Case Study Report

    Energy Technology Data Exchange (ETDEWEB)

    Bank, J.; Mather, B.; Keller, J.; Coddington, M.

    2013-01-01

    Technical concerns with integrating higher penetrations of photovoltaic (PV) systems include grid stability, voltage regulation, power quality (voltage rise, sags, flicker, and frequency fluctuations), and protection and coordination. The current utility grid was designed to accommodate power flows from the central generation source to the transmission system and eventually to the distribution feeders. At the distribution level, the system was designed to carry power from the substation toward the load. Renewable distributed generation, particularly solar PV, provides power at the distribution level challenging this classical paradigm. As these resources become more commonplace the nature of the distribution network and its operation is changing to handle power flow in both directions. This report is focused on large PV installations in which penetration is significantly greater than 15% of maximum daytime feeder load. These case studies are intended to demonstrate success stories with integration of large PV plants at the distribution level as well as some of the solutions used by the utility to ensure safe, reliable operation of both the PV system and the distribution network.

  4. Hybrid Risk Management Methodology: A Case Study

    Directory of Open Access Journals (Sweden)

    Jacky Siu-Lun Ting

    2009-10-01

    Full Text Available Risk management is a decision-making process involving considerations of political, social, economic and engineering factors with relevant risk assessments relating to a potential hazard. In the last decade, a number of risk management tools are introduced and employed to manage and minimize the uncertainty and threats realization to the organizations. However, the focus of these methodologies are different; in which companies need to adopt various risk management principles to visualize a full picture of the organizational risk level. Regarding to this, this paper presents a new approach of risk management that integrates Hierarchical Holographic Modeling (HHM, Enterprise Risk Management (ERM and Business Recovery Planning (BCP for identifying and assessing risks as well as managing the consequences of realized residual risks. To illustrate the procedures of the proposed methodology, a logistic company ABC Limited is chosen to serve as a case study Through applying HHM and ERM to investigate and assess the risk, ABC Limited can be better evaluated the potential risks and then took the responsive actions (e.g. BCP to handle the risks and crisis in near future.

  5. Dynamic optimization case studies in DYNOPT tool

    Science.gov (United States)

    Ozana, Stepan; Pies, Martin; Docekal, Tomas

    2016-06-01

    Dynamic programming is typically applied to optimization problems. As the analytical solutions are generally very difficult, chosen software tools are used widely. These software packages are often third-party products bound for standard simulation software tools on the market. As typical examples of such tools, TOMLAB and DYNOPT could be effectively applied for solution of problems of dynamic programming. DYNOPT will be presented in this paper due to its licensing policy (free product under GPL) and simplicity of use. DYNOPT is a set of MATLAB functions for determination of optimal control trajectory by given description of the process, the cost to be minimized, subject to equality and inequality constraints, using orthogonal collocation on finite elements method. The actual optimal control problem is solved by complete parameterization both the control and the state profile vector. It is assumed, that the optimized dynamic model may be described by a set of ordinary differential equations (ODEs) or differential-algebraic equations (DAEs). This collection of functions extends the capability of the MATLAB Optimization Tool-box. The paper will introduce use of DYNOPT in the field of dynamic optimization problems by means of case studies regarding chosen laboratory physical educational models.

  6. Comparative economic analysis: Anaerobic digester case study

    International Nuclear Information System (INIS)

    An economic guide is developed to assess the value of anaerobic digesters used on dairy farms. Two varieties of anaerobic digesters, a conventional mixed-tank mesophilic and an innovative earthen psychrophilic, are comparatively evaluated using a cost-effectiveness index. The two case study examples are also evaluated using three other investment merit statistics: simple payback period, net present value, and internal rate of return. Life-cycle savings are estimated for both varieties, with sensitivities considered for investment risk. The conclusion is that an earthen psychrophilic digester can have a significant economic advantage over a mixed-tank mesophilic digester because of lower capital cost and reduced operation and maintenance expenses. Because of this economic advantage, additional projects are being conducted in North Carolina to increase the rate of biogas utilization. The initial step includes using biogas for milk cooling at the dairy farm where the existing psychrophilic digester is located. Further, a new project is being initiated for electricity production with thermal reclaim at a swine operation

  7. Jazz improvisers' shared understanding: a case study.

    Science.gov (United States)

    Schober, Michael F; Spiro, Neta

    2014-01-01

    To what extent and in what arenas do collaborating musicians need to understand what they are doing in the same way? Two experienced jazz musicians who had never previously played together played three improvisations on a jazz standard ("It Could Happen to You") on either side of a visual barrier. They were then immediately interviewed separately about the performances, their musical intentions, and their judgments of their partner's musical intentions, both from memory and prompted with the audiorecordings of the performances. Statements from both (audiorecorded) interviews as well as statements from an expert listener were extracted and anonymized. Two months later, the performers listened to the recordings and rated the extent to which they endorsed each statement. Performers endorsed statements they themselves had generated more often than statements by their performing partner and the expert listener; their overall level of agreement with each other was greater than chance but moderate to low, with disagreements about the quality of one of the performances and about who was responsible for it. The quality of the performances combined with the disparities in agreement suggest that, at least in this case study, fully shared understanding of what happened is not essential for successful improvisation. The fact that the performers endorsed an expert listener's statements more than their partner's argues against a simple notion that performers' interpretations are always privileged relative to an outsider's. PMID:25152740

  8. Refugee Problem in Europe – Case Studies

    Directory of Open Access Journals (Sweden)

    Esztella Varga

    2015-11-01

    Full Text Available The European refugee problem has grown dramatically in the last few months, putting a considerable amount of pressure on the European countries. Not only are they facing migrants from North Africa, but from the Middle East as well.In March 2011 the Arab Spring has reached Syria, causing a huge number of Syrians to flee their country and seek asylum in Turkey, and possibly going further to the EU. The refugees who fled Syria as well as those who are leaving North Africa (mostly the failed state of Libya are aiming to reach European soil, but Italy, Greece or Turkey is not ready to handle the amount of refugees. The cooperation of the Mediterranean countries and Europe has not been able to slow down the flow of refugees, and the Mediterranean and Aegean seas have become dangerous routes for the desperate migrants who attempt the sea-crossing. In my analysis I would like to highlight the role of the so-called elements of ‘soft power’ in the way of dealing with the refugee problem. According to my hypothesis, the issue can’t be successfully addressed using only the means of the ‘soft power’. No real solution for the crisis has been offered yet, and I would like to give case studies of the different ways of dealing with the problem – inside (Greece, Italy and outside (Turkey of the European Union.

  9. Environmental injustice: case studies from the South

    International Nuclear Information System (INIS)

    We selected three case studies to illustrate environmental injustice issues in the South. These examples relate to migrant agricultural workers, the maquiladora industry and artisanal mining, while reviewing some of the major mechanisms involved, e.g. multinational corporations, the development of free trade zones, multilateral free trade agreements and the export of hazards. A series of strategies are discussed in order to address environmental injustice and health disparities that exist on a global scale. Some of the recommendations involve policy initiatives; others, such as research and mentorship, fall within the traditional domain of public health practice. In this paper, special attention is given to concerned environmental and occupational health professionals using evidence-based data for advocacy. For lasting changes to be made, however, stronger institutions and legislation are required. Those who have the 'right to know' about environmental injustice issues include communities of concern, workers' representatives and lawyers. Government officials and company officials may eventually work on the basis of conflict resolution, compensation and remediation, to quote some examples. Systematic approaches to protect both the environment and public health must be updated

  10. Arabidopsis Hormone Database: a comprehensive genetic and phenotypic information database for plant hormone research in Arabidopsis

    OpenAIRE

    Peng, Zhi-Yu; Zhou, Xin; Li, Linchuan; Yu, Xiangchun; Li, Hongjiang; Jiang, Zhiqiang; Cao, Guangyu; Bai, Mingyi; Wang, Xingchun; Jiang, Caifu; Lu, Haibin; Hou, Xianhui; Qu, Lijia; Wang, Zhiyong; Zuo, Jianru

    2008-01-01

    Plant hormones are small organic molecules that influence almost every aspect of plant growth and development. Genetic and molecular studies have revealed a large number of genes that are involved in responses to numerous plant hormones, including auxin, gibberellin, cytokinin, abscisic acid, ethylene, jasmonic acid, salicylic acid, and brassinosteroid. Here, we develop an Arabidopsis hormone database, which aims to provide a systematic and comprehensive view of genes participating in plant h...

  11. Evaluations of Regional Competitiveness: Making a Case for Case Studies

    OpenAIRE

    Barkley, David L.

    2008-01-01

    This paper provides an overview of the concepts of regional competitiveness, including definitions, conceptual models, measurements, and the benefits and shortcomings of following a strategy to enhance competitiveness. Next, city-region rankings and indices of competitiveness are reviewed and the usefulness of these studies is summarized. Potential roles for regional scientists for improving (1) evaluations of regional competitiveness and (2) applications of evaluations to regional developmen...

  12. Cases for the Net Generation: An Empirical Examination of Students' Attitude toward Multimedia Case Studies

    Science.gov (United States)

    Sheppard, Michael; Vibert, Conor

    2016-01-01

    Case studies have been an important tool in business, legal, and medical education for generations of students. Traditional text-based cases tend to be self-contained and structured in such a way as to teach a particular concept. The multimedia cases introduced in this study feature unscripted web-hosted video interviews with business owners and…

  13. Mathematical modelling with case studies using Maple and Matlab

    CERN Document Server

    Barnes, B

    2014-01-01

    Introduction to Mathematical ModelingMathematical models An overview of the book Some modeling approaches Modeling for decision makingCompartmental Models Introduction Exponential decay and radioactivity Case study: detecting art forgeries Case study: Pacific rats colonize New Zealand Lake pollution models Case study: Lake Burley Griffin Drug assimilation into the blood Case study: dull, dizzy, or dead? Cascades of compartments First-order linear DEs Equilibrium points and stability Case study: money, money, money makes the world go aroundModels of Single PopulationsExponential growth Density-

  14. Case studies on age-management in organisations: report on organisational case studies

    OpenAIRE

    Punte, E.; Conen, W.S.; Schippers, J.; Henkens, C.J.I.M.

    2011-01-01

    The acquisition of case studies was thwarted by the economic crisis and the feeling of being ‘over-researched’ by potential organisations. Although organisations in some sectors (e.g. chemical manufacturing) reported the worst part of the economic crisis was behind, many organisations indicated getting through the crisis was their top priority. Especially in the first few months we had difficulties with getting through to organisations. The most difficulties we had at that time with longitudi...

  15. Structured Controversy: A Case Study Strategy.

    Science.gov (United States)

    Herreid, Clyde Freeman

    1996-01-01

    Introduces a dynamic form of the case instruction method that involves debate and compromise. Discusses two versions of structured controversy and presents an example of structured controversy that involves the use of DNA fingerprinting in forensic medicine. (JRH)

  16. Jane: A Case Study in Anorexia Nervosa.

    Science.gov (United States)

    Willingham, Barbara

    1988-01-01

    The article reports the case history of a 15-year-old Australian girl with anorexia nervosa. Information is also given on prevalence, causes, definitions, and treatments including hospitalization, co-therapy, psychotherapy, behavior modification, family therapy, and counseling. (DB)

  17. Phyllodes tumor in adolescent. Case study.

    OpenAIRE

    Lidia Torres Aja; Julio Sarmiento Sánchez; María Caridad Rubio Hernández

    2008-01-01

    Presentation of the case of a patient (18 years old) who was assisted in the provincial mastology consultation for a non painful tumor, of sudden growth covering almost all the right breast, without other symptom or sing. After some tests, it was decided to operate. The tumor turned to be benign phyllodes. The relevance of this case lies in the infrequent appearance of this type of tumor, being even the first to be operated in our hospital.

  18. Brazilian oil spills chemical characterization : case studies

    International Nuclear Information System (INIS)

    The Petrobras Research Centre has been active in responding to some significant oil spills in Brazil in the past decade. The centre has characterized spilled oil, monitored the affected ecosystems and determined the fate of oil in the environment. This paper described the use of some advanced chemical analytical techniques used in Brazilian oil spill studies to determine fractions and individual petroleum hydrocarbons in water, groundwater, sediment, sand, fish and the spilled oil itself. Some of the most recent oil spill cases were discussed in terms of chemical characterization of the spilled oil and the environmental samples from different matrices of the affected ecosystems for determining the fate of the oil in the environment and to assess environmental damage. In particular, methods such as gas chromatography/flame ionization detector, P and T/GC/PID and gas chromatography/mass spectrometry have been used to examine crude and fuel oil spills in Guanabara Bay, Barigui and Iguassu Rivers, and the Sao Sebastiao Channel. The chemical analytical methods are used to determine total petroleum hydrocarbons, n-alkanes, isoprenoids, unresolved complex mixtures, volatile monoaromatic compounds such as BTEX (benzene, toluene, ethylbenzene and xylenes), as well as parent and alkylated homologues polycyclic aromatic hydrocarbons (PAH) and terpanes and steranes. Acute ecotoxicity data for water and sediment samples was also included. It was determined that with certain limitations, PAH ratios can help determine the origin of hydrocarbons as being either petrogenic or pyrolytic. However, alkylated PAH homologues and parent compounds such as dibenzothiophene and perylene give more precise interpretation of the data. 30 refs., 9 tabs., 11 figs

  19. Omics analysis of high-energy Arabidopsis thaliana

    OpenAIRE

    Liang, Chao; 梁超

    2014-01-01

    Arabidopsis thaliana purple acid phosphatase 2 (AtPAP2) is a phosphatase dually targeted to both chloroplasts and mitochondria. Overexpression (OE) of AtPAP2 in Arabidopsis thaliana was reported to speed up plant growth and promote flowering, seed yield and biomass at maturity in a previous study. Under long-day (16 hours light at 22°C / 8 hours dark at 18°C) growth conditions, the leaves of 20-day-old OE lines contained significant higher sucrose and glucose than the wild-type (WT) plants, r...

  20. Protocol: optimised electrophyiological analysis of intact guard cells from Arabidopsis

    Directory of Open Access Journals (Sweden)

    Chen Zhong-Hua

    2012-05-01

    Full Text Available Abstract Genetic resources available for Arabidopsis thaliana make this species particularly attractive as a model for molecular genetic studies of guard cell homeostasis, transport and signalling, but this facility is not matched by accessible tools for quantitative analysis of transport in the intact cell. We have developed a reliable set of procedures for voltage clamp analysis of guard cells from Arabidopsis leaves. These procedures greatly simplify electrophysiological recordings, extending the duration of measurements and scope for analysis of the predominant K+ and anion channels of intact stomatal guard cells to that achieved previously in work with Vicia and tobacco guard cells.

  1. Fourier transform-infrared studies on the effects of salt and drought stress on the chemical composition and pro-tein conformation changes in Arabidopsis leaves

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    We examined the changes of chemical composition and protein conformation in Arabidopsis leaves by Fourier transform-infrared (FT-IR) spectrometry Arabidopsis under 50 mmol/L NaCl salt and -0.5 mPa polyethylene glycols 8000 (PEG 8000) drought stress during the early stages of growth.We primarily analyzed the absorption band areas in the 1,745 cm-1 (ester),1,600-1,700 cm-1 (amide I),and 1,100 cm-1 (carbohydrate) changes under salt stress and drought stress within 24 hours.The results showed that ester content declined at the beginning and then increased steadily during 24 hours of drought stress.But under salt stress,it de-clined steadily,and it was about 40 percent of the control after 24 hours.The protein synthesis increased by 25 percent after one hour of salt stress and then reached about 85 percent of the control after 24 hours.Under drought stress,the protein synthesis de-creased and reached aminimal level at the 4-hr time point;it then recovered to the control level at the 24-hr point.The patterns of the accumulation of carbohydrates in the 1,100 cm-1 band areas resembled that of amide I band changes under drought stress and salt stress.Analyzing the ratio A1,627cm-1/A1,658cm-1 under drought stress revealed that the leaves’ entire protein structure maintained a higher-level ordered form than did those under salt stress.Thus our results indicate the existence of different strategies of the Arabidopsis adaptation to salt stress and drought stress.

  2. A Case Study Model for Augmentative and Alternative Communication Outcomes

    Science.gov (United States)

    Hill, Katya

    2006-01-01

    Case studies are an accepted method for reporting treatment outcomes. However, to be useful and authentic, a systematic and principled approach to collecting, analyzing, and reporting case data must be observed. This paper proposes a basic case study format for documenting augmentative and alternative communication (AAC) intervention to ensure…

  3. Case Studies In Business Market Research: An Abductive Approach

    OpenAIRE

    DuBois, A.; Gadde, L

    1999-01-01

    Case studies are frequently used in industrial network research. In this paper we discuss the difficulties and opportunities characterizing the case study approach. In particular we deal with single case research aiming at theory generation. For this purpose we suggest an approach based on 'systematic combining' grounded in an 'abductive' logic.

  4. A clinico-pathological study of 70 cases of pemphigus

    Directory of Open Access Journals (Sweden)

    Arya S

    1999-01-01

    Full Text Available A clinicopalhological study of 70 cases of pemphigus observed over a span of four and a half years from January 1992 to June 1996 at the Sir J.J. Group of Hospitals and Grant Medical College, Mumbai is reported. Pemphigus vulgaris constituted the single largest group of 43 cases, followed by pemphigus foliaceus (25 cases and pemphigus vegetans (2 cases. Majority of the cases were seen in the age group of 21-60 years, with a slight male predominance. The youngest patient was 14 years while the eldest was aged 75 years. Mucosal involvement was seen in 31 cases of pemphigus vulgaris, as opposed to only 5 cases of pemphigus foliaceus. Flaccid bullae were present in 100% cases. Pruritus was complained of in 14 cases, though it was more common in pemphigus vegetans and vulgaris. Salient histopathological features of pemphigus vulgaris observed were (I intraepidermal suprabasal blisters (35 cases, (2 presence of acantholytic cells (40 cases, (3 "Row of tombstone appearance" (I8 cases and (4 acantholysis involving follicular sheath (20 cases. Main histopathological features of pemphigus foliaceus were (1 subcorneal blister (15 case, (2 acantholysis (24 cases and (3 bulla cavity containing inflammatory infiltrate (12 cases. Both cases of pemphigus vegetans showed hyperkeratosis, papillomatosis and irregular acanthosis with intra-epidermal eosinophilic abscesses besides suprabasal lacunae.

  5. On misunderstandings in connection with case-studies

    DEFF Research Database (Denmark)

    Flyvbjerg, Bent

    2005-01-01

    and concludes with the Kuhnian insight that a scientific discipline without a large number of thoroughly executed case studies is a discipline without systematic production of exemplars, and that a discipline without exemplars is an ineffective one. Social science may be strengthened by the execution......This article examines five common misunderstandings about case-study research: (1) Theoretical knowledge is more valuable than practical knowledge; (2) One cannot generalize from a single case, therefore the single case study cannot contribute to scientific development; (3) The case study is most...... useful for generating hypotheses, while other methods aremore suitable for hypotheses testing and theory building; (4) The case study contains a bias toward verification; and (5) It is often difficult to summarize specific case studies. The article explains and corrects these misunderstandings one by one...

  6. Antenatal stress: An Irish case study.

    LENUS (Irish Health Repository)

    Carolan-Olah, Mary

    2013-05-16

    BACKGROUND:: stress in pregnancy is common and impacts negatively on women, infants and families. A number of factors contribute to high levels of stress in pregnancy, including financial concerns, marital discord, low support systems and low socio-economic status. OBJECTIVES:: the aim of this study was to evaluate stress anxiety levels and depressive symptoms among low risk women in an area in Ireland that was particularly impacted by the 2008 economic crisis. DESIGN:: a quantitative descriptive cross-sectional design was used. Data were collected using the Edinburgh Postnatal Depression Scale (EPDS), the Perceived Stress Scale and the State Trait Anxiety Inventory (STAI). Data was collected at a single time during the second trimester. SETTING:: this paper reports a case study of one maternity service in Ireland. Participants included low risk pregnant women who were attending the hospital clinic for routine antenatal care. RESULTS:: of 150 questionnaires distributed, 74 completed questionnaires were returned indicating a 49.3% return rate. Findings indicated high levels of stress, anxiety and depressive symptomatology among participants. There were no significant difference in mean EPDS score for different age groups (F4,69=2.48, P=0.052), living arrangements (F4,68=0.90, P=0.5) or usual occupation (F4,69=1.45, P=0.2). A score of ≥12 was taken as indicative of probable antenatal depression and 86.5% of participants responded with a score of 12 or above. PSS scores were also high and more than three quarters of respondents scored ≥15 (75.6%) and more than a third had scores ≥20 (35.1%), out of a total score of 40. There was a significant difference in mean PSS score between the different age groups (F4,69=3.60, P=0.010) but not for living arrangements or usual occupation. A STAI score of ≥39 was taken as indicative of antenatal anxiety, and 74.3% of participants responded with a score of 39 or above. There were no significant differences in mean STAI

  7. Studies on five cases of radiation enterocolitis

    Energy Technology Data Exchange (ETDEWEB)

    Yasunaga, Akira; Shibata, Okihiko; Kubo, Hironobu; Tomonari, Kazuhide; Hadama, Tetsuo; Uchida, Yuzou; Shirabe, Joji (Oita Medical Coll. (Japan))

    1990-05-01

    Five patients with radiation enterocolitis who were surgically treated are reported. The 5 patients had received irradiation therapy more than 5,000 rad for ginecologic malignancies. The period for the onset of symptoms of irradiation enteritis ranged from 8 months to 20 years however, 3 of them developed the symptoms within one year after irradiation therapy. Emergency surgery was carried out for bowel obstruction in 3 cases and for intestinal perforation in 2 cases. Bowel resection and primary anastomosis were performed by a one-step approach in 4 of them. Transient colostomy as preventive measure was added in 2 cases. It is very important for the one-step approach to resect the intestine at the healthy part far from the lesion of irradiation enteritis and to add a transient colostomy to prevent anastomolic insufficiency. Furthermore, suture material should be used less tissue reactive one. (author).

  8. The use of case studies in teaching undergraduate neuroscience.

    Science.gov (United States)

    Meil, William M

    2007-01-01

    Case studies have been the cornerstone of many discoveries in neurology and continue to be an indispensable source of knowledge. Attaching a name, face, and story to the study of neurological disorders makes them more "real" and memorable. This article describes the value of the case study methodology and its advantages as a pedagogical approach. It also illustrates how the seminal case of H.M. can be used to highlight the advantages and disadvantages of the case study methodology. Three exercises are described for incorporating case studies into neuroscience courses. The first exercise requires students to conduct a literature review regarding their assigned case and then design an experiment to address a lingering question regarding that neurological disorder. Survey results of 90 students provide quantitative and qualitative support for this approach. The vast majority of students indicated this exercise was a valuable learning experience; sparked interest in the topic and in biopsychology; increased their knowledge and stimulated critical thinking. The second exercise discusses how students might conduct their own case studies. The third exercise emphasizes the use of case studies as a platform to examine competing hypotheses regarding neurological conditions and their treatment. A table listing case studies appropriate for undergraduate neuroscience courses is included. Cases are categorized by the type of neurological disorder and notes regarding the nature of and content of each case are provided. PMID:23493154

  9. DDACE cogeneration systems : 10 case studies

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    DDACE Power Systems are experts in green energy power generation and provide solutions that deal with waste and industrial by-products. The company develops practical energy solutions that address environmental and financial concerns facing both industrial and municipal customers. The following 10 case studies are examples of the installations that DDACE Power Systems have completed in recent years: (1) a combined heat and emergency power installation on the roof of a 19 storey apartment building on Bloor Street in Toronto, Ontario. The cogeneration package provides electricity and heat to the entire building, replacing an old diesel generator, (2) a combined heat and emergency power installation at the Villa Colombo extended care facility in Vaughan, Ontario. The cogeneration system provides heat and power to the building, as well as emergency power, (3) emergency standby power with demand response capabilities at Sobeys Distribution Warehouse in Vaughan, Ontario. The primary purpose of the 2.4 MW low emission, natural gas fuelled emergency standby generator is to provide emergency power to the building in the event of a grid failure, (4) a dual fuel combined heat and power installation at the Queensway Carleton Hospital in Ottawa, Ontario that provides electricity, hot water and steam to all areas of the hospital, (5) a tri-generation installation at the Ontario Police College in Aylmer, Ontario which provides power and heat to the building as well as emergency power in the event of a grid failure. An absorption chiller provides cooling in the summer and an exhaust emission control system reduces NOx emissions, (6) a biomass gasification installation at Nexterra Energy in Kamloops, British Columbia. The 239 kW generator is fueled by synthesis gas, (7) biogas utilization at Fepro Farms in Cobden, Ontario for treatment of the facility's waste products. The biogas plant uses cow manure, as well as fats, oil and grease from restaurants to produce electricity and

  10. Case studies: Soil mapping using multiple methods

    Science.gov (United States)

    Petersen, Hauke; Wunderlich, Tina; Hagrey, Said A. Al; Rabbel, Wolfgang; Stümpel, Harald

    2010-05-01

    Soil is a non-renewable resource with fundamental functions like filtering (e.g. water), storing (e.g. carbon), transforming (e.g. nutrients) and buffering (e.g. contamination). Degradation of soils is meanwhile not only to scientists a well known fact, also decision makers in politics have accepted this as a serious problem for several environmental aspects. National and international authorities have already worked out preservation and restoration strategies for soil degradation, though it is still work of active research how to put these strategies into real practice. But common to all strategies the description of soil state and dynamics is required as a base step. This includes collecting information from soils with methods ranging from direct soil sampling to remote applications. In an intermediate scale mobile geophysical methods are applied with the advantage of fast working progress but disadvantage of site specific calibration and interpretation issues. In the framework of the iSOIL project we present here some case studies for soil mapping performed using multiple geophysical methods. We will present examples of combined field measurements with EMI-, GPR-, magnetic and gammaspectrometric techniques carried out with the mobile multi-sensor-system of Kiel University (GER). Depending on soil type and actual environmental conditions, different methods show a different quality of information. With application of diverse methods we want to figure out, which methods or combination of methods will give the most reliable information concerning soil state and properties. To investigate the influence of varying material we performed mapping campaigns on field sites with sandy, loamy and loessy soils. Classification of measured or derived attributes show not only the lateral variability but also gives hints to a variation in the vertical distribution of soil material. For all soils of course soil water content can be a critical factor concerning a succesful

  11. Capturing Cultural Glossaries: Case-study I *

    Directory of Open Access Journals (Sweden)

    Matete Madiba

    2011-10-01

    Full Text Available

    Abstract: This article is a presentation of a brief cultural glossary of Northern Sotho cooking terms. The glossary is mainly composed of names for utensils and ingredients, and action words for the processes involved in the preparation of cultural dishes. It also contains names of dishes tied to some idiomatic expressions in a way eliciting cultural experiences that can lead to an under-standing of indigenous knowledge systems. The article seeks to explore ways of capturing cultural glossaries to feed into the national dictionary corpora by using a case-study approach to investigate the processes that led to the generation of this specific school-based project. A number of issues that surfaced in this project, can possibly serve as models for the collection of authentic glossaries that can support dictionary making in African languages.

    Keywords: CULTURAL GLOSSARY, INDIGENOUS KNOWLEDGE SYSTEMS, CULTURAL TERMINOLOGY, CORPUS, AUTHENTIC GLOSSARY, CONTEXTUALISATION, MARGIN-ALIZED LANGUAGES, OUTCOMES-BASED EDUCATION, PERFORMANCE INDICATOR, ASSESSMENT CRITERIA, RANGE STATEMENT, TRADITIONAL DISHES, LANGUAGE VAL-ORISATION, SIMULTANEOUS FEEDBACK, COMMUNICATIVE APPROACH, STRUCTURAL APPROACH, METONYMY

    Opsomming: Die totstandbrenging van kulturele woordversamelings: Ge-vallestudie I. Hierdie artikel is 'n aanbieding van 'n kort kulturele woordversameling van Noord-Sothokookterme. Die woordversameling bestaan hoofsaaklik uit die name van gereedskap en bestanddele, en handelingswoorde vir die prosesse betrokke by die voorbereiding van kulturele geregte. Dit bevat ook name van geregte wat verbind is met sekere idiomatiese uitdrukkings wat op 'n manier kulturele ervarings oproep wat kan lei tot die verstaan van inheemse kennisstelsels. Die artikel probeer om maniere te ondersoek waarop kulturele woordversamelings in die nasionale woordeboekkorpusse ingevoer kan word deur 'n gevallestudiebenadering te volg om die prosesse te ondersoek wat tot die

  12. Olympus Imaging Fraud Scandal: A Case Study

    Science.gov (United States)

    Elam, Dennis; Madrigal, Marion; Jackson, Maura

    2014-01-01

    This case examines the two decade long tobashi scheme by Olympus Imaging Executives to hide $1.7 billion in losses. In the 1980s, a soaring yen and falling dollar caused bottom line income problems for many Japanese companies. Some companies sought to offset the declining revenue with zaiteku, a form of speculative investment. While early…

  13. Supply chain strategy: empirical case study in Europe and Asia:

    OpenAIRE

    Sillanpää, Ilkka; Sillanpää, Sebastian

    2014-01-01

    The purpose of this case study research is to present a literature review of supply chain strategy approaches, develop supply chain strategy framework and to validate a framework in empirical case study. Literature review and case study research are the research methods for this research. This study presents the supply chain strategy framework which merges together business environment, corporate strategy, supply chain demand and supply chain strategy. Research argues that all the different c...

  14. Mucocele - A study of 36 cases

    Directory of Open Access Journals (Sweden)

    Jani Dhaval

    2010-01-01

    Full Text Available Background: Mucocele is one of the most common benign soft tissue tumor present in the oral cavity. They are of two types - one is extravasation and second one is retention type but the majority are extravasation type. Aims: The objective is to determine various factors related to mucocele such as role of trauma due to nearby teeth, recurrence, duration, and to find out whether there is any role of psychological stress which initiates trauma like lip or cheek biting. Materials and Methods: 36 cases of mucocele diagnosed at the Department of the Oral Pathology, Govt. Dental College and Hospital, Ahmedabad, between 2004 and 2008 were reviewed. The clinical data were recorded and histopathologic diagnosis was made. Statistical Analysis Used: Data analysis tool, Microsoft Office Excel 2007. Results: A diagnosis of mucocele was established in 36 cases with male-to-female ratio of 1.77:1. Most common type was extravasation in 30 (83.33% cases. The peak age of occurrence was between 1st and 3rd decade. Lateral side of the lower labial mucosa was the most affected site in 34 (94.44% cases. The history of trauma appeared the major etiological factor seen in 28 (77.77% cases. Conclusion: We conclude that there was male predominance and they were more affected in 2nd and 3rd decade. The lateral side of lower labial mucosa was the commonest site and the trauma due to teeth or lip biting was the major etiological factor for the occurrence of the mucocele. The article highlights role of psychological stress in occurrence of mucocele. The reader should understand the importance of histopathology examination and should try to control the psychological stress in such mucocele patients.

  15. Identification of Ambiguity in the Case Study Research Typology

    DEFF Research Database (Denmark)

    Grünbaum, Niels Nolsøe

    2015-01-01

    future. Relevant to varied levels and scales of case study use, the aim of this collection is to provide readers with a comprehensive overview of where we are now with case study research, so that they may better judge their own applications of the case study. From definitions to interdisciplinary...... illustrations being adopted in the collection would provide comparative perspectives and international insights to scholars who are interested in English language studies in Asia." This collection takes a dutifully contemporary approach to the exploration of the uses and interpretations of the case study across...

  16. Delusional parasitosis--study of 3 cases.

    Directory of Open Access Journals (Sweden)

    Hanumantha K

    1994-10-01

    Full Text Available Delusional disorder-somatic (parasitosis type is a rare psychiatric disorder which poses a challenge to diagnostic and therapeutic skills. Pimozide, a highly specific dopamine blocker has shown promising results in the 3 cases illustrated here. These cases were seen over a period of 3 years. All the three patients believed that an insect has entered through the ear and is burrowing tracts/laying multiple eggs. They approached the ENT surgeons or neurosurgeon with a fear that their brain will be invaded. On psychiatric evaluation, no past or present history of major psychiatric illness was found. Premorbid personalities were well adjusted. Only for two patients, acute moderate stressors were detected. Delusions disappeared by the end of 2 wks but therapy was continued for 5 months.

  17. Case study the poultry industry in Colombia

    OpenAIRE

    Gomez, Miguel I.; Sierra, Diego M.; Rodriguez, Daisy

    2003-01-01

    "As developing countries open their economies further to trade, their food industries are striving to raise safety and quality standards in order to compete in new markets. Such is the case with the Colombian poultry industry... Critical questions face the Colombian poultry industry: Is it ready to compete with foreign poultry producers on price, quality, and safety? Can industry efforts to produce better quality products assure an increased share of domestic and regional markets? This brief ...

  18. Ostearticular Retroperitoneal Actinomycosis. A Case Study

    International Nuclear Information System (INIS)

    Actinomycosis is a chronic granulomatous bacterial infection which tends to result in the formation of abscesses and cutaneous fistulas. Its most common pathogenic agent is Actinomyces israeli, which is a common commensal of the human mouth and gastrointestinal tract. Retroperitoneal actinomycosis is rare, and even more so is its affecting bones and joints. Presented here is a case of osteoarticular retroperitoneal actinomycosis. Pertinent literature is also reviewed. (Author) 28 refs

  19. Insider Threat Case Studies at Radiological and Nuclear Facilities

    International Nuclear Information System (INIS)

    Seven case studies are presented. The cases include thefts of various materials and sabotage. For each case there is an overview of the incident, a timeline, a profile of the perpetrator, and a discussion of the security system failures which allowed the incident to take place.

  20. Communicating Ocean Sciences to Informal Audiences (COSIA): Case Studies

    Science.gov (United States)

    Inverness Research, 2010

    2010-01-01

    The three case studies presented in this paper are descriptive and evaluative in nature, and are designed to describe, explain, and portray in some detail three examples of COSIA partnerships. These cases are context bound; the place-based aspect of these cases is critical to the phenomenon being explored. Consistent with the goal for employing a…

  1. Insider Threat Case Studies at Radiological and Nuclear Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Pope, Noah Gale [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hobbs, Christopher [Centre for Science and Security Studies, London (United Kingdom)

    2015-04-13

    Seven case studies are presented. The cases include thefts of various materials and sabotage. For each case there is an overview of the incident, a timeline, a profile of the perpetrator, and a discussion of the security system failures which allowed the incident to take place.

  2. Television Medical Dramas as Case Studies in Biochemistry

    Science.gov (United States)

    Millard, Julie T.

    2009-01-01

    Several case studies from popular television medical dramas are described for use in an undergraduate biochemistry course. These cases, which illustrate fundamental principles of biochemistry, are used as the basis for problems that can be discussed further in small groups. Medical cases provide an interesting context for biochemistry with video…

  3. Orbital dermoid and epidermoid cysts: Case study

    Directory of Open Access Journals (Sweden)

    Veselinović Dragan

    2010-01-01

    Full Text Available Introduction. Dermoid and epidermoid cysts of the orbit belong to choristomas, tumours that originate from the aberrant primordial tissue. Clinically, they manifest as cystic movable formations mostly localized in the upper temporal quadrant of the orbit. They are described as both superficial and deep formations with most frequently slow intermittent growth. Apart from aesthetic effects, during their growth, dermoid and epidermoid cysts can cause disturbances in the eye motility, and in rare cases, also an optical nerve compression syndrome. Case Outline. In this paper, we described a child with a congenital orbital dermoid cyst localized in the upper-nasal quadrant that was showing signs of a gradual enlargement and progression. The computerized tomography revealed a cyst of 1.5-2.0 cm in size. At the Maxillofacial Surgery Hospital in Niš, the dermoid cyst was extirpated in toto after orbitotomy performed by superciliary approach. Postoperative course was uneventful, without inflammation signs, and after two weeks excellent functional and aesthetic effects were achieved. Conclusion. Before the decision to treat the dermoid and epidermoid cysts operatively, a detailed diagnostic procedure was necessary to be done in order to locate the cyst precisely and determine its size and possible propagation into the surrounding periorbital structures. Apart from cosmetic indications, operative procedures are recommended in the case of cysts with constant progressions, which cause the pressure to the eye lobe, lead to motility disturbances and indirectly compress the optical nerve and branches of the cranial nerves III, IV and VI.

  4. Effect of magnetic fields on cryptochrome-dependent responses in Arabidopsis thaliana.

    Science.gov (United States)

    Harris, Sue-Re; Henbest, Kevin B; Maeda, Kiminori; Pannell, John R; Timmel, Christiane R; Hore, P J; Okamoto, Haruko

    2009-12-01

    The scientific literature describing the effects of weak magnetic fields on living systems contains a plethora of contradictory reports, few successful independent replication studies and a dearth of plausible biophysical interaction mechanisms. Most such investigations have been unsystematic, devoid of testable theoretical predictions and, ultimately, unconvincing. A recent study, of magnetic responses in the model plant Arabidopsis thaliana, however, stands out; it has a clear hypothesis-that seedling growth is magnetically sensitive as a result of photoinduced radical-pair reactions in cryptochrome photoreceptors-tested by measuring several cryptochrome-dependent responses, all of which proved to be enhanced in a magnetic field of intensity 500 muT. The potential importance of this study in the debate on putative effects of extremely low-frequency electromagnetic fields on human health prompted us to subject it to the 'gold standard' of independent replication. With experimental conditions chosen to match those of the original study, we have measured hypocotyl lengths and anthocyanin accumulation for Arabidopsis seedlings grown in a 500 microT magnetic field, with simultaneous control experiments at 50 microT. Additionally, we have determined hypocotyl lengths of plants grown in 50 microT, 1 mT and approximately 100 mT magnetic fields (with zero-field controls), measured gene (CHS, HY5 and GST) expression levels, investigated blue-light intensity effects and explored the influence of sucrose in the growth medium. In no case were consistent, statistically significant magnetic field responses detected. PMID:19324677

  5. USING CASE STUDIES AS AN APPROACH FOR CONDUCTING AGRIBUSINESS RESEARCH

    OpenAIRE

    Sterns, James A.; Schweikhardt, David B.; Peterson, H. Christopher

    1998-01-01

    Many agricultural economists are not familiar with case study research, yet the approach is a useful means of collecting data, and building and testing theory. Case study research has a prescribed set of objectives, epistemology, methodology, and methods that have been developed and tested in a wide range of scholarly and pragmatic situations. This paper reviews these fundamentals, and then demonstrates the case study approach within the context of an agribusiness research project. This appli...

  6. Interactive verification of Markov chains: Two distributed protocol case studies

    OpenAIRE

    Johannes Hölzl; Tobias Nipkow

    2012-01-01

    Probabilistic model checkers like PRISM only check probabilistic systems of a fixed size. To guarantee the desired properties for an arbitrary size, mathematical analysis is necessary. We show for two case studies how this can be done in the interactive proof assistant Isabelle/HOL. The first case study is a detailed description of how we verified properties of the ZeroConf protocol, a decentral address allocation protocol. The second case study shows the more involved verification of anonymi...

  7. Use of Case Studies for Stimulating Thinking and Learning.

    Science.gov (United States)

    Zeakes, Samuel J.

    Noting that a case-study approach can stimulate student thinking and learning, this paper describes how students in a writing-intensive course on parasitology wrote brief medical case studies of parasites already studied for other students to read, evaluate, and identify the parasite. The paper presents a brief description of the course, an…

  8. A Mixed Methods Sampling Methodology for a Multisite Case Study

    Science.gov (United States)

    Sharp, Julia L.; Mobley, Catherine; Hammond, Cathy; Withington, Cairen; Drew, Sam; Stringfield, Sam; Stipanovic, Natalie

    2012-01-01

    The flexibility of mixed methods research strategies makes such approaches especially suitable for multisite case studies. Yet the utilization of mixed methods to select sites for these studies is rarely reported. The authors describe their pragmatic mixed methods approach to select a sample for their multisite mixed methods case study of a…

  9. Risk ratio estimation in case-cohort studies.

    OpenAIRE

    Sato, T

    1994-01-01

    In traditional (cumulative-incidence) case-control studies, the exposure odds ratio can be used as an estimator of the risk ratio only when the disease under study is rare. The case-cohort study is a recently developed useful modification of the case-control study. This design allows direct estimation of the risk ratio from a fixed cohort, but does not require any rare-disease assumption. This article reviews recent developments in risk ratio estimation procedures for the analysis of case-coh...

  10. Arabidopsis Rab Geranylgeranyltransferases Demonstrate Redundancy and Broad Substrate Specificity in Vitro.

    Science.gov (United States)

    Shi, Wan; Zeng, Qin; Kunkel, Barbara N; Running, Mark P

    2016-01-15

    Posttranslational lipid modifications mediate the membrane attachment of Rab GTPases, facilitating their function in regulating intracellular vesicular trafficking. In Arabidopsis, most Rab GTPases have two C-terminal cysteines and potentially can be double-geranylgeranylated by heterodimeric Rab geranylgeranyltransferases (Rab-GGTs). Genes encoding two putative α subunits and two putative β subunits of Rab-GGTs have been annotated in the Arabidopsis thaliana genome, but little is known about Rab-GGT activity in Arabidopsis. In this study, we demonstrate that four different heterodimers can be formed between putative Arabidopsis Rab-GGT α subunits RGTA1/RGTA2 and β subunits RGTB1/RGTB2, but only RGTA1·RGTB1 and RGTA1·RGTB2 exhibit bona fide Rab-GGT activity, and they are biochemically redundant in vitro. We hypothesize that RGTA2 function might be disrupted by a 12-amino acid insertion in a conserved motif. We present evidence that Arabidopsis Rab-GGTs may have preference for prenylation of C-terminal cysteines in particular positions. We also demonstrate that Arabidopsis Rab-GGTs can not only prenylate a great variety of Rab GTPases in the presence of Rab escort protein but, unlike Rab-GGT in yeast and mammals, can also prenylate certain non-Rab GTPases independently of Rab escort protein. Our findings may help to explain some of the phenotypes of Arabidopsis protein prenyltransferase mutants. PMID:26589801

  11. Understanding Support - lessons from a case study

    OpenAIRE

    Chris Sauer

    1993-01-01

    Support from top management and others is agreed to be an important factor in information systems success and failure, but little is written about how it has its effect and how it might be managed to a project's advantage. A recently developed conceptual framework is described. It covers the nature and forms of support, the way support affects project outcomes, the bases on which support is provided, and the strategies by which support may be managed. The framework is used to analyse a case s...

  12. Stethoscopes with hearing aid use: Case studies

    Directory of Open Access Journals (Sweden)

    Jacob, Regina Tangerino de Souza

    2013-01-01

    Full Text Available Introduction: Description for using stethoscopes adapted to hearing aids. Aim: To describe the adaptation of HAs to stethoscopes used by 2 students in the health field with bilateral hearing impairment. Case reports: Two subjects with hearing loss had their stethoscopes coupled to HAs because of the individual requirements of their professions (healthcare to perform auscultation. Conclusion: The improvement was measured in situ, and satisfaction was evaluated using a subjective questionnaire. The use of a stethoscope coupled to an HA allowed students with hearing loss to perform auscultation.

  13. Pelvic kidney in organ donation: case study.

    Science.gov (United States)

    Yushkov, Yuriy; Giudice, Anthony

    2009-12-01

    An ectopic kidney is a rare congenital anomaly that occurs when the kidney fails to ascend to its normal position. Often an ectopic kidney is asymptomatic and the kidney is an unexpected finding during organ recovery. The kidney described in this case report had normal function and could have been used for transplantation, if it had been recovered without 2 renal arteries being damaged because of anatomic variation. The renal vasculature in this type of abnormality usually ascends from the iliac vessels, and this variation in anatomy should be taken into consideration by the recovering surgeon during arterial cannulation for organ flushing. PMID:20050461

  14. Case studies for developing globally responsible engineers

    OpenAIRE

    Global Dimension in Engineering Education

    2015-01-01

    Document realitzat amb un ajut financer de la Unió Europea. Per poder accedir al material complementari per a docents dels 28 casos estudi que formen el llibre, activeu el "Document relacionat" Col·lecció de 28 casos estudi per a professors d'enginyeria: 1. Rural development and planning in LDCs: the “Gamba Deve – Licoma axis”,district of Caia, Mozambique 2. Reducing the impact of soil erosion and reservoir siltation on agricultural production and water availability: the case stu...

  15. Understanding energy poverty - Case study: Tajikistan

    Energy Technology Data Exchange (ETDEWEB)

    Robic, Slavica; Olshanskaya, Marina; Vrbensky, Rastislav; Morvaj, Zoran

    2010-09-15

    Access and affordability to energy services determine the state of energy poverty; however, there is no widely applicable definition of energy poverty and no universal set of measures for its eradication exists. This paper offers a new definition and possible solution for decrease, and eventually eradication, of energy poverty for the specific case of Tajikistan. As eradication of energy poverty needs to go in hand with nature preservation and economic development, authors provide possible approach to decrease of energy poverty in Tajikistan while simultaneously preserving nature and boosting the local economy.

  16. STUDY OF SIGNIFICANCE OF PLATELET COUNT IN FEVER CASES

    Directory of Open Access Journals (Sweden)

    Vasavilatha

    2015-01-01

    Full Text Available AIM: To study the significance of platelet count in various fevers and also identify the common causes of fever with thrombocytopenia . MATERIALS AND METHODS: 69 patients who were admitted with fever over 2 months of period from 15th October to15th December 2014 in King George Hospital AMC Visakhapatnam studied retrospectively. RESULTS: INCIDENCE: More than half of the cases (52.2% admitted with fever have thrombocytopenia. SEX: The study reveals that irrespective of sex and size of the sample the presentation of fever with/ without thromb ocytopenia could not found any significant difference . Degree of thrombocytopenia in various etiologies: in the present study it is found that out of 15 cases of falciparum malaria 10 cases had thrombocytopenia. Out of 12 undiagnosed cases 8 cases had thro mbocytopenia. Out of 4 cases of gastro intestinal system 3 cases had thrombocytopenia. In the present study it is significantly found that the highest difference is noticed in the presentation of dengue cases. Out of total sample (69 cases it is found tha t 5cases (7.2% of thrombocytopenia with dengue fever were found against 1case (1.4% of dengue fever with normal plate let count. The present study reveals that there is significant difference among various diseases such as malaria 14 (16.6%, dengue feve r 5 (13.9%, Urinary tract infection 2 (5.6%, undiagnosed cases 8 (22.2%. However severe thrombocytopenia (platelets less than 50,000 is seen in14 cases (38.8%out of 36 cases of fever with thrombocytopenia. Further this study reveals that in the cases of malaria 50% of cases reported as severe thrombocytopenia 7cases (19.4% followed by dengue fever3 cases (8.3%. CONCLUSION: Not only malaria, dengue fever and urinary tract infection can also cause severe thrombocytopenia. Fever cases especially with th rombocytopenia show seasonal variations, they are seen commonly in early winter. Febrile thrombocytopenia still presents as atypical and occult forms making

  17. Logistics Outsourcing: Lessons from Case Studies

    Directory of Open Access Journals (Sweden)

    Aldo Srabotic

    2012-06-01

    Full Text Available This paper investigates key success factors in logistics outsourcing. Amodel is used to illustrate outsourcing relationships and then appliedto three examples from the logistics sector. The model is presented asa tool which can help managers to minimize the chance of failure byexplicitly addressing key issues prior to the implementation of a partnership.In order to fully capture the complexity of the outsourcingprocess, the model is refined by the analysis of implementation of outsourcingmethodology and the analysis of the presence of outsourcingmyths in each case. We find that the implementation of outsourcingmethodology is critical to successful outsourcing. Overall, we find thatthe main common factors leading to logistics outsourcing success, afterthe right third party service provider has been selected, are improvedservice levels and commercial viability for both parties, joint vision andobjectives of the partnership, clear roles, top management commitmentand support, communication and trust. The results of the case analysisshed light on what is the key to a successful outsourcing relationshipand indicate how the architecture of logistics outsourcing can be analyzedand improved.

  18. Overexpression of Arabidopsis AnnAt8 Alleviates Abiotic Stress in Transgenic Arabidopsis and Tobacco

    Science.gov (United States)

    Yadav, Deepanker; Ahmed, Israr; Shukla, Pawan; Boyidi, Prasanna; Kirti, Pulugurtha Bharadwaja

    2016-01-01

    Abiotic stress results in massive loss of crop productivity throughout the world. Because of our limited knowledge of the plant defense mechanisms, it is very difficult to exploit the plant genetic resources for manipulation of traits that could benefit multiple stress tolerance in plants. To achieve this, we need a deeper understanding of the plant gene regulatory mechanisms involved in stress responses. Understanding the roles of different members of plant gene families involved in different stress responses, would be a step in this direction. Arabidopsis, which served as a model system for the plant research, is also the most suitable system for the functional characterization of plant gene families. Annexin family in Arabidopsis also is one gene family which has not been fully explored. Eight annexin genes have been reported in the genome of Arabidopsis thaliana. Expression studies of different Arabidopsis annexins revealed their differential regulation under various abiotic stress conditions. AnnAt8 (At5g12380), a member of this family has been shown to exhibit ~433 and ~175 fold increase in transcript levels under NaCl and dehydration stress respectively. To characterize Annexin8 (AnnAt8) further, we have generated transgenic Arabidopsis and tobacco plants constitutively expressing AnnAt8, which were evaluated under different abiotic stress conditions. AnnAt8 overexpressing transgenic plants exhibited higher seed germination rates, better plant growth, and higher chlorophyll retention when compared to wild type plants under abiotic stress treatments. Under stress conditions transgenic plants showed comparatively higher levels of proline and lower levels of malondialdehyde compared to the wild-type plants. Real-Time PCR analyses revealed that the expression of several stress-regulated genes was altered in AnnAt8 over-expressing transgenic tobacco plants, and the enhanced tolerance exhibited by the transgenic plants can be correlated with altered expressions of

  19. Methodology Series Module 2: Case-control Studies.

    Science.gov (United States)

    Setia, Maninder Singh

    2016-01-01

    Case-Control study design is a type of observational study. In this design, participants are selected for the study based on their outcome status. Thus, some participants have the outcome of interest (referred to as cases), whereas others do not have the outcome of interest (referred to as controls). The investigator then assesses the exposure in both these groups. The investigator should define the cases as specifically as possible. Sometimes, definition of a disease may be based on multiple criteria; thus, all these points should be explicitly stated in case definition. An important aspect of selecting a control is that they should be from the same 'study base' as that of the cases. We can select controls from a variety of groups. Some of them are: General population; relatives or friends; and hospital patients. Matching is often used in case-control control studies to ensure that the cases and controls are similar in certain characteristics, and it is a useful technique to increase the efficiency of the study. Case-Control studies can usually be conducted relatively faster and are inexpensive - particularly when compared with cohort studies (prospective). It is useful to study rare outcomes and outcomes with long latent periods. This design is not very useful to study rare exposures. Furthermore, they may also be prone to certain biases - selection bias and recall bias. PMID:27057012

  20. Methodology series module 2: Case-control studies

    Directory of Open Access Journals (Sweden)

    Maninder Singh Setia

    2016-01-01

    Full Text Available Case-Control study design is a type of observational study. In this design, participants are selected for the study based on their outcome status. Thus, some participants have the outcome of interest (referred to as cases, whereas others do not have the outcome of interest (referred to as controls. The investigator then assesses the exposure in both these groups. The investigator should define the cases as specifically as possible. Sometimes, definition of a disease may be based on multiple criteria; thus, all these points should be explicitly stated in case definition. An important aspect of selecting a control is that they should be from the same 'study base' as that of the cases. We can select controls from a variety of groups. Some of them are: General population; relatives or friends; and hospital patients. Matching is often used in case-control control studies to ensure that the cases and controls are similar in certain characteristics, and it is a useful technique to increase the efficiency of the study. Case-Control studies can usually be conducted relatively faster and are inexpensive – particularly when compared with cohort studies (prospective. It is useful to study rare outcomes and outcomes with long latent periods. This design is not very useful to study rare exposures. Furthermore, they may also be prone to certain biases – selection bias and recall bias.

  1. Arabidopsis Heterotrimeric G-protein Regulates Cell Wall Defense and Resistance to Necrotrophic Fungi

    Institute of Scientific and Technical Information of China (English)

    Magdalena Delcado-Cerezo; Paul Schulze-Lefert; Shauna Somerville; José Manuel Estevez; Staffan Persson; Antonio Molina; Clara Sánchez-Rodríguez; Viviana Escudero; Eva Miedes; Paula Virginia Fernández; Lucía Jordá; Camilo Hernández-Blanco; Andrea Sánchez-Vallet; Pawel Bednarek

    2012-01-01

    The Arabidopsis heterotrimeric G-protein controls defense responses to necrotrophic and vascular fungi.The agb1 mutant impaired in the Gβ subunit displays enhanced susceptibility to these pathogens.Gβ/AGB1 forms an obligate dimer with either one of the Arabidopsis Gγ subunits (γ1/AGG1 and γ2/AGG2).Accordingly,we now demonstrate that the agg1 agg2 double mutant is as susceptible as agb1 plants to the necrotrophic fungus Plectosphaerella cucumerina.To elucidate the molecular basis of heterotrimeric G-protein-mediated resistance,we performed a comparative transcriptomic analysis of agb1-1 mutant and wild-type plants upon inoculation with P cucumerina.This analysis,together with metabolomic studies,demonstrated that G-protein-mediated resistance was independent of defensive pathways required for resistance to necrotrophic fungi,such as the salicylic acid,jasmonic acid,ethylene,abscisic acid,and tryptophan-derived metabolites signaling,as these pathways were not impaired in agb1 and agg1 agg2 mutants.Notably,many mis-regulated genes in agb1 plants were related with cell wall functions,which was also the case in agg1 agg2 mutant.Biochemical analyses and Fourier Transform InfraRed (FTIR) spectroscopy of cell walls from G-protein mutants revealed that the xylose content was lower in agb1 and agg1 agg2 mutants than in wild-type plants,and that mutant walls had similar FTIR spectratypes,which differed from that of wild-type plants.The data presented here suggest a canonical functionality of the Gβ and Gγ1/γ2 subunits in the control of Arabidopsis immune responses and the regulation of cell wall composition.

  2. Wrinkled1, a ubiquitous regulator in oil accumulating tissues from Arabidopsis embryos to oil palm mesocarp.

    Directory of Open Access Journals (Sweden)

    Wei Ma

    Full Text Available Wrinkled1 (AtWRI1 is a key transcription factor in the regulation of plant oil synthesis in seed and non-seed tissues. The structural features of WRI1 important for its function are not well understood. Comparison of WRI1 orthologs across many diverse plant species revealed a conserved 9 bp exon encoding the amino acids "VYL". Site-directed mutagenesis of amino acids within the 'VYL' exon of AtWRI1 failed to restore the full oil content of wri1-1 seeds, providing direct evidence for an essential role of this small exon in AtWRI1 function. Arabidopsis WRI1 is predicted to have three alternative splice forms. To understand expression of these splice forms we performed RNASeq of Arabidopsis developing seeds and queried other EST and RNASeq databases from several tissues and plant species. In all cases, only one splice form was detected and VYL was observed in transcripts of all WRI1 orthologs investigated. We also characterized a phylogenetically distant WRI1 ortholog (EgWRI1 as an example of a non-seed isoform that is highly expressed in the mesocarp tissue of oil palm. The C-terminal region of EgWRI1 is over 90 amino acids shorter than AtWRI1 and has surprisingly low sequence conservation. Nevertheless, the EgWRI1 protein can restore multiple phenotypes of the Arabidopsis wri1-1 loss-of-function mutant, including reduced seed oil, the "wrinkled" seed coat, reduced seed germination, and impaired seedling establishment. Taken together, this study provides an example of combining phylogenetic analysis with mutagenesis, deep-sequencing technology and computational analysis to examine key elements of the structure and function of the WRI1 plant transcription factor.

  3. Wrinkled1, a ubiquitous regulator in oil accumulating tissues from Arabidopsis embryos to oil palm mesocarp.

    Science.gov (United States)

    Ma, Wei; Kong, Que; Arondel, Vincent; Kilaru, Aruna; Bates, Philip D; Thrower, Nicholas A; Benning, Christoph; Ohlrogge, John B

    2013-01-01

    Wrinkled1 (AtWRI1) is a key transcription factor in the regulation of plant oil synthesis in seed and non-seed tissues. The structural features of WRI1 important for its function are not well understood. Comparison of WRI1 orthologs across many diverse plant species revealed a conserved 9 bp exon encoding the amino acids "VYL". Site-directed mutagenesis of amino acids within the 'VYL' exon of AtWRI1 failed to restore the full oil content of wri1-1 seeds, providing direct evidence for an essential role of this small exon in AtWRI1 function. Arabidopsis WRI1 is predicted to have three alternative splice forms. To understand expression of these splice forms we performed RNASeq of Arabidopsis developing seeds and queried other EST and RNASeq databases from several tissues and plant species. In all cases, only one splice form was detected and VYL was observed in transcripts of all WRI1 orthologs investigated. We also characterized a phylogenetically distant WRI1 ortholog (EgWRI1) as an example of a non-seed isoform that is highly expressed in the mesocarp tissue of oil palm. The C-terminal region of EgWRI1 is over 90 amino acids shorter than AtWRI1 and has surprisingly low sequence conservation. Nevertheless, the EgWRI1 protein can restore multiple phenotypes of the Arabidopsis wri1-1 loss-of-function mutant, including reduced seed oil, the "wrinkled" seed coat, reduced seed germination, and impaired seedling establishment. Taken together, this study provides an example of combining phylogenetic analysis with mutagenesis, deep-sequencing technology and computational analysis to examine key elements of the structure and function of the WRI1 plant transcription factor. PMID:23922666

  4. Effect of cultural conditions on the seed-to-seed growth of Arabidopsis and Cardamine - A study of growth rates and reproductive development as affected by test tube seals

    Science.gov (United States)

    Hoshizaki, T.

    1982-01-01

    The effects of test tube seals on the growth, flowering, and seed pod formation of Arabidopsis thaliana (L.) Heynh., mouse ear cress, and Cardamine oligosperma Nutt, bitter cress, are studied in order to assess the conditions used in weightlessness experiments. Among other results, it is found that the growth (height) and flowering (date of bud appearance) were suppressed in mouse ear cress in tubes sealed with Saran. Seed pod formation which occurred by day 45 in open-to-air controls, was still lacking in the sealed plants even up to day 124. The growth and flowering of bitter cress were also suppressed by the Saran seal, although up to day 55 the Saran-sealed plants were taller. It is suggested that atmospheric composition was the cause of the suppression of growth, flowering, and seed pod development in these plants, since the mouse ear cress renewed their growth and then set seed pods after the Saran seal was ruptured.

  5. Brazil Low Carbon Case Study : Transport

    OpenAIRE

    World Bank

    2011-01-01

    This report summarizes the results for the transportation sector from a larger study, the low carbon study for Brazil, developed by the World Bank as part of its initiative to support the integrated efforts of Brazil to reduce global and national greenhouse gases emissions, while promoting long-term development. The study covers four key areas with potential low carbon options: 1) Land Use...

  6. A molecular-genetic approach to studying source-sink interactions in Arabidopsis thaliana. Final report, April 1, 1995--March 31, 1998

    Energy Technology Data Exchange (ETDEWEB)

    Gibson, S.I.

    1998-11-01

    The ultimate goal of this research is to elucidate the molecular mechanisms by which the complex interactions between sources and sinks of fixed carbon are controlled in plants. As soluble sugar levels have been shown to play a vital role in a variety of source-sink interactions, a key aspect of the authors research is to determine the role of sugar-regulated gene expression in mediating source-sink interactions. In addition, as a critical aspect of source-sink interactions is the channeling of fixed carbon into different storage forms, they have pursued the findings that fumaric acid represents a significant form of storage carbon in Arabidopsis thaliana and other plant species. In the future, a better understanding of the mechanisms by which interactions between sources and sinks of fixed carbon are coordinated will be a pre-requisite to developing more rationale approaches to improving harvest indices in crop species.

  7. Atrophic Nonunion - a Radiological Case Study

    International Nuclear Information System (INIS)

    This paper reports a rare case of complications following the fore arm fracture in a female Italian greyhound aged 8 months. The radiographic examination showed a fracture in the distal one-fifth of the radial bone dysphasia, and a double fracture of the ulna at the distal one-fifth and one-fourth of the dysphasia. Owing to the incidence of other traumas, no improvement in the clinical state, and the persistent motility of the fractured bone fragments, subsequent radiographs were taken after 3, 5, 6, and 18 months after the first examination. Within the 18-month follow-up, no bone union was recorded. The last follow-up examination revealed advanced bone atrophy. The radial bone was severely narrowed and shortened by 50% as compared to the primary length. The ulna bone had nearly atrophied completely. (author)

  8. Methylbromide intoxication: a clinical case study.

    Science.gov (United States)

    Breeman, Wim

    2009-01-01

    The port of Rotterdam, The Netherlands, is the world's largest container port. In 2006, one of these containers caused a chemical incident. Methylbromide is used in some countries as a pesticide for the fumigation of maritime containers. Because of an insufficiently performed detoxification, this insecticide intoxicated several employees and some of the ambulance crew and Mobile Medical Team (MMT). The victims displayed symptoms of sore throat, irritated eyes, and hypersalivation. One of the victims suffered from multiple epileptic seizures. Two victims were admitted to the intensive care unit for respiratory support. Three other employees showed milder symptoms and received supportive care but were not admitted to the hospital. This complicated case shows that the safety of the ambulance crew and MMT must be guaranteed. It also demonstrates that healthcare providers cannot always oversee the accident scene and that there are some pitfalls that are almost impossible to prevent. PMID:20118865

  9. Lake Orta: a case study (Part 1

    Directory of Open Access Journals (Sweden)

    Renato BAUDO

    2001-02-01

    Full Text Available Preface The extraordinary case of industrial pollution in Lake Orta was followed and documented by the Istituto Italiano di Idrobiologia from its very origin in 1926. Many papers were published regarding the effects of the pollution on chemistry and biology of the lake but they were scattered in various scientific journals and in a long time period. Now the time has come to draw the conclusions of our long work and the long history of the lake. We planned to publish a monographic volume, but technical reasons made it impossible to realise this project. The papers which could have formed the volume will be splitted into issues 60(1 and 60(2 of Journal of Limnology.

  10. 磷脂酶D对拟南芥抗冻性的影响%Study on the Effect of Phospholipase D on the Freezing Tolerance of Arabidopsis thaliana

    Institute of Scientific and Technical Information of China (English)

    赵鹏; 王道龙

    2011-01-01

    为了探索磷脂酶D(PLD)在调控植物抗冻性中的作用,进一步揭示植物抗冻机理和磷脂低温信号转导机制的研究.笔者应用人工气候霜箱,对PLDγ1、PLDγ3基因分别被敲除的拟南芥突变体及野生型材料,进行低温驯化和冻害胁迫处理.试验发现,这2个基因的敲除型无论是经过还是未经过低温驯化冻害处理的离子渗漏率都与相同处理野生型拟南芥的离子渗漏率无显著差异.试验结果表明,PLDT,1和PLDy3这2个基因既未参与组成型调控植物的抗冻性,也未参与低温信号转导过程.%The experiment was purposely to research the effect of phospholipase D on the freezing tolerance of Arabidopsis thaliana, reveal the mechanism of plants freezing tolerance and phospholipid signal transduction.Arabidopsis thaliana mutant PLDγ1 or PLDγ3 was deficient and wild-type was used as materials.The two mutants and wild-type were cold acclimated and freezing stressed using a climate chamber.There were no significant differences between the ion leakage of the mutants and wild-type whether cold acclimation freeze or non-acclimation freeze.The results showed that PLDγ1 and PLDγ3 neither mediate regulation of constitutive freezing tolerance nor low temperature signaling.

  11. Transmission electron microscopy of ameloblastoma: A study on six cases

    OpenAIRE

    Chawla, Rajeshwar; Ramalingam, Karthikeyan; Sarkar, Amitabha; Muddiah, Savita

    2013-01-01

    Background: Ameloblastoma is a rare, benign tumor of odontogenic epithelium, but with an aggressive clinical behavior. Aim: The present study aims to assess the ultramicroscopic features of the epithelial and connective tissue components of ameloblastoma. Materials and Methods: Six cases of ameloblastoma were subjected to electron microscopy. They included three cases of follicular type and three cases of plexiform type. Results: The study reveals that the ameloblastoma contains the full comp...

  12. THE APPLICATION OF CASE STUDY IN ENGINEERING DRAWING COURSE

    OpenAIRE

    Zhang, Wenying; Yuan, Yuefeng

    2015-01-01

    The paper describes the case study in engineering drawing course in the process of assembly drawing by using customized software. The process is reflecting three steps of an engineering case solving: design, processing and installation. Using case study for design drawings students can master the main components of assembly drawing, understand assembly drawing and learn the AutoCAD software. All this can improve the quality of teaching.

  13. Logistics case study based research: Towards higher quality

    DEFF Research Database (Denmark)

    Pedrosa, Alex; Näslund, Dag; Jasmand, Claudia

    2012-01-01

    analysis of 134 case study based articles published in six leading logistics and supply chain management (SCM) journals between 1998 and 2010 is used to assess and evaluate the quality of the case study based research approach as documented in these publications. Findings – This research provides an...... overview of the quality of the case study based research approach. Results show that the quality is generally low, supporting the ongoing, but empirically unsupported criticism on the quality of case study based research. The results also highlight which specific aspects authors and reviewers need to...... address to ensure high quality of the case study based research approach in published articles. Research limitations/implications – This study is limited to the analysis of published articles in six logistics and SCM journals. Further research should investigate different journals in logistics and other...

  14. Studying Tourism Indicators In Iran (Case Study: Khoramabad City

    Directory of Open Access Journals (Sweden)

    Mahdi Garavand

    2014-12-01

    Full Text Available Now tourism industry is one of the greatest World Industries from point of view development and with attention to be use financial sources and involved persons with that. This industry, has third rank in financial and commercial classifications and including more than 7 percent of whole world exports, also it influence gross national product in all countries; so that increase rate of gross national product 2billion $ in all world nations. Tourism industry important to stress tow important ways: first, the dynamic familiarity with other cultures, nations, races, tribes, dialects and …; second, it provides sources of income and foreign exchanges from an economic point of view. The different world countries fallowed attraction of tourists because of that they have various facilities and various attractions.Iran is ranked as one of the 10 top attractive countries in the world but Iran was place 114th ranking of the countries in terms of attracting tourists (World Economic Forum, 2011, tourism receipts is ranked as 77th, and the number of international tourists arrivals ranked as place 70th (UNWTO, 2009.So, the aim of this research is, studying main indicators in tourism location in order to improving their qualify. This research is qualitative. Also was used the "Descriptive/ Explanatory" through contain analysis. The research method are phenomenological, conceptual and constructive theory in field of tourism industry in context of Iran, Which eventually is bound to lead to the development of tourism industry in Iran. The strategy of this research is qualitative method by using case study in the area of tourism industry in fabric of Iran. So, was introduced touristic-historical building. Then according to visitor comments was ranked. At finally was used T-Test method in order to analyzing hypothesis.

  15. A Case Study on Science Teacher Trainees

    OpenAIRE

    Tekkaya, Ceren; Middle East Technical University, Department of Elementary Education; Çakıroğlu, Jale; Middle East Technical University, Dep. of Elementary Education; Özkan, Özlem; Middle East Technical University, Department of Secondary Science and Math Education

    2002-01-01

    The main purposes of this study were to investigate pre-service science teachers’ understanding of science concepts, their attitudes toward science teaching and their beliefs of their efficacy in science teaching. A total of 85 pre-service science teachers participated in the study. All students were sophomores who had taken various science courses during previous semesters and were still studying science. Data collection instruments included the Science Concept Test, The Science Teaching Eff...

  16. Personal Development Plans: Case Studies of Practice. Report 280.

    Science.gov (United States)

    Tamkin, P.; And Others

    The use and effectiveness of personal development plans (PDPs) in planning career and skill development activities for individuals within employing organizations in the United Kingdom was examined through case studies of seven firms and telephone interviews with representatives of seven other firms. The case studies/interviews focused on the…

  17. Using Clinical Gait Case Studies to Enhance Learning in Biomechanics

    Science.gov (United States)

    Chester, Victoria

    2011-01-01

    Clinical case studies facilitate the development of clinical reasoning strategies through knowledge and integration of the basic sciences. Case studies have been shown to be more effective in developing problem-solving abilities than the traditional lecture format. To enhance the learning experiences of students in biomechanics, clinical case…

  18. The Case Study: A Strategy for Gifted Students.

    Science.gov (United States)

    McMahon, Edward T.

    1982-01-01

    Using the case study method as the primary teaching strategy in law-related education is particularly appropriate with gifted students because of its emphasis on critical thinking and independent learning. Steps in the case study approach are reviewed, and a sample clasroom application of the approach is offered. (Author/SW)

  19. Release and deployment at Planon: a case study

    NARCIS (Netherlands)

    Jansen, R.L.; Ballintijn, G.C.; Brinkkemper, S.

    2005-01-01

    This case study report describes the research results of a case study at Planon into the processes of development, release, and deployment. The research was done to document the release and deployment processes at Planon, to uncover strengths and weaknesses in these processes, and to compare Planon

  20. Hamlet's Suicide Soliloquy: A Case Study in Suicide Ideology.

    Science.gov (United States)

    Jenkins, Andrew P.

    This paper presents a secondary-level teaching technique that can be used in an integrated English and health education curriculum. The exercise provides students and teachers with a case study of a suicidal person for the purpose of teaching the warning signs of suicide, appropriate questioning, and referral skills. The case study uses Hamlet's…

  1. Concessioning of the Ifrikya Railway : A Case Study

    OpenAIRE

    Budin, Karim-Jacques

    2003-01-01

    The case study of the concessioning of the Ifrikya railway is based in part on several recent actual case studies on railway concessioning in Sub-Saharan Africa. However, several features of the general context and data have been changed for pedagogical purposes. The Republic of Ifrikya should therefore be considered an entirely fictitious country and the description of conditions there sh...

  2. Communicative Case Studies for EFL--Lessons for Interactivity.

    Science.gov (United States)

    Witte, Anne E.

    1999-01-01

    Discusses use of case studies and role play throughout the curriculum at the Ecole de Hautes Etudes Commerciales du Nord, a French graduate school associated with the Catholic University of Lille. Provides a case study that was developed to reconcile conflicting needs in the business English classroom at the graduate level. Students require…

  3. Cancer Advocacy in Africa: case studies of innovative practices

    OpenAIRE

    Odedina, Folakemi T; Rodrigues, Belmira

    2013-01-01

    In this paper, we present six case studies describing innovative cancer advocacy programs in Africa. For each case study, an example of an advocacy activity, list of factors contributing to the success of the organization, and an example of an obstacle addressed by the organization are described.

  4. Using a Case-Study Article to Effectively Introduce Mitosis

    Science.gov (United States)

    Van Hoewyk, Doug

    2007-01-01

    Community college students in a nonmajors biology class are introduced to mitosis by reading a case-study article that allows them to gauge how many times various parts of their bodies have been regenerated. The case-study article allows students to develop a conceptual framework of the cell cycle prior to a lecture on mitosis. (Contains 1 figure.)

  5. Bridging the Performance Gap with Ergonomics: A Case Study

    Science.gov (United States)

    Rethaber, James D.

    2011-01-01

    Faced with increased incidences of work-related strain and sprain injuries and OSHA-recordable injuries, the organization in this case study details how it resolved these performance-related issues. This case study also demonstrates the effectiveness of Thomas Gilbert's (1978) Behavior Engineering Model as a tool for analyzing, defining, and…

  6. Nanomaterial Case Studies: Nanoscale Titanium Dioxide (External Review Draft)

    Science.gov (United States)

    This draft document presents two case studies of nanoscale titanium dioxide (nano-TiO2) used (1) to remove arsenic from drinking water and (2) as an active ingredient in topical sunscreen. The draft case studies are organized around a comprehensive environmental asses...

  7. Brazil Low Carbon Case Study : Waste

    OpenAIRE

    World Bank

    2010-01-01

    This report synthesis the findings for the waste sector of a broader study, the Brazil low carbon study, which was undertaken by the World Bank in its initiative to support Brazil's integrated effort towards reducing national and global emissions of Greenhouse Gases (GHG) while promoting long term development. The purpose of the present report is to assist in the preparation of public poli...

  8. Masculinity Studies: The Case of Brando

    Science.gov (United States)

    Pinto, Samantha

    2011-01-01

    This reflective article interrogates the role of masculinity studies in the women's and gender studies' classroom by looking at the work of American film icon Marlon Brando. Brando and his risky masculinity in the film represents a locale of "dangerous desires" which reveal deep conflict in student perceptions of men, women, and gender. (Contains…

  9. only: A Case Study In Projective Meaning

    Directory of Open Access Journals (Sweden)

    Craige Roberts

    2010-12-01

    Full Text Available I offer an integrated theory of the meaning of only in which the prejacent, while not presupposed, is both entailed and backgrounded, hence tends to project (following a general proposal about projection due to Simons et al. 2010. Moreover, I argue, contra Beaver & Brady (2008, that only is not conventionally associated with focus, the focus effects arising instead pragmatically. But I do adopt aspects of their semantics for only, including the presupposition of a pre-order over the elements of its domain.ReferencesAbbott, B. 2000. ‘Presuppositions as non-assertions’. Journal of Pragmatics 32: 1419–37.http://dx.doi.org/10.1016/S0378-2166(9900108-3Abbott, B. 2008. ‘Presuppositions and common ground’. Linguistics and Philosophy 31: 523–538.http://dx.doi.org/10.1007/s10988-008-9048-8Amaral, P. 2010. ‘Entailment, assertion, and textual coherence: the case of almost and barely’. Linguistics 48, no. 3: 525–545.http://dx.doi.org/10.1515/LING.2010.016Amaral, P., Roberts, C. & Allyn Smith, E. 2008. ‘Review of The Logic of Conventional Implicature by Chris Potts’. Linguistics and Philosophy 30: 707–749.http://dx.doi.org/10.1007/s10988-008-9025-2Atlas, J. D. 1993. ‘The importance of being “only”: testing the neo-Gricean versus neoentailment paradigms’. Journal of Semantics 10: 301–18.http://dx.doi.org/10.1093/jos/10.4.301Beaver, D. 2001. Presupposition and Assertion in Dynamic Semantics. CSLI Publications, Stanford, CA.Beaver, D. 2010. ‘Handout from a talk on projective meaning’. Stuttgart, Germany.Beaver, D. & Brady, C. 2003. ‘Always and Only: Why not all focus sensitive operators are alike’. Natural Language Semantics 11: 323–62.http://dx.doi.org/10.1023/A:1025542629721Beaver, D. & Brady, C. 2008. Sense and Sensitivity. Blackwell.http://dx.doi.org/10.1002/9781444304176Beckman, M. E. & Ayers, G. M. 1994. ‘Guidelines for ToBI labeling guide, ver. 2.0’. On-line at The Ohio State University: www

  10. Phenotypic analysis of Arabidopsis mutants: oomycete pathogens.

    Science.gov (United States)

    Clarke, Joseph D

    2009-10-01

    Various fungal pathogens are used in Arabidopsis pathogen studies, including Fusarium oxysporum, Alternaria brassicicola, Botrytis cinerea, and others. The oomycete pathogen Peronospora parasitica has been used by several groups and is described in this protocol. Working with Peronospora is complicated by the fact that it is an obligate biotroph, and consequently cultures must be maintained on living plants. There is no central repository for Peronospora stocks, but most investigators who work with them are willing to provide samples of infected tissue. These can be used to initiate new stock cultures, or they can be maintained as live cultures on seedlings. One of the most important factors in maintaining Peronospora is the humidity of the growth chamber, which must be kept at a minimum of 80%. Various Peronospora isolates are available. These vary with respect to which Arabidopsis ecotypes they can infect, because some combinations trigger gene-for-gene resistance. Thus, it is important that the appropriate ecotype is inoculated with the appropriate strain of pathogen. The extent of infections can be rated or quantitatively measured as the number of spores produced per plant, and frozen tissue stocks can be prepared from heavily infected tissue. PMID:20147042

  11. Tourette Syndrome neuropsychological profile: a study case

    Directory of Open Access Journals (Sweden)

    Eliana Gomes da Silva Almeida

    2014-04-01

    Full Text Available This article discusses findings resulting from the neuro-psychological assessment of an adolescent with Tourette Syndrome (TS, a rare neuro-developmental disorder characterized by the manifestation of physical and/or audible tics that emerge in childhood or early adolescence. Although we performed an extensive assessment of all cognitive functions, our reported findings focus on those functions that are described in prior research as relevant to the understanding of the cognitive profile of patients with this condition. The findings reported here are consistent with other reports and suggest that intellectual and long-term memory potentials are preserved, while noting deficiencies in executive functioning, reduced speed of mental and psycho-motor functions, and decreased recent memory capacity. Given the rarity of this diagnosis, our reporting of this case should contribute to the understanding of cognitive function in adolescents with TS. In addition, this article highlights and describes factors that affect the quality of neuropsychological assessment and facilitate accurate therapeutical diagnosis and referral for TS carriers.

  12. A case study in finite groups

    International Nuclear Information System (INIS)

    Recent investigations on the classification of rational conformal theories have suggested relations with finite groups. It is not known at present if this is more than a happy coincidence in simple cases or possibly some more profound link exploiting the analogy between fusion rules and decompositions of tensor products of group representations or even in a more abstract context q-deformations of Lie algebras for roots of unity. Although finite group theory is a very elaborate subject the authors review on a slightly non-trivial example some of its numerous aspects, in particular those related to rings of invariants. The hope was to grasp, if possible, some properties which stand a chance of being related to conformal theories. Subgroups of SU(2) were found to be related to the A-D-E classification of Wess-Zumino-Witten models based on the corresponding affine Lie algebra. Extending the investigations to SU(3) the authors have picked one of its classical subgroups as a candidate of interest

  13. Metallurgy of platinoids. Studies of industrial cases

    International Nuclear Information System (INIS)

    The platinoids deposits, currently in exploitation, are often associated with dunitic and gabbroitic ultra-basic rocks containing copper, nickel and iron sulfides. The proportion of platinoids in these deposits is variable and requires generally an adaptation of the industrial processes for their recovery. Nevertheless, we can consider that the classical industrial way consists to treat the composite concentrates of copper-nickel-platinoids sulfides by melting/conversion operations following by hydrometallurgical operations of recovery of the basic metals Cu, Ni. These last ones concentrate the platinoids in leaching residues. In these residues, the platinoids are extracted and separated by hydrometallurgical ways including different techniques: dissolution, selective precipitation, distillation, solvent extraction, resins...The great variety of uses of platinoids makes their recycling difficult. The wastes are often too complex for being economically recycling. The environmental protection depends of the type of industry (metallurgical, chemical, mining). Some products present risks of fire and explosion. The toxicity often appears by superficial allergies and by serious troubles in case of ingestion of soluble salts. (O.M.)

  14. Moire Techniques In Biomedical Case Studies

    Science.gov (United States)

    Soares, O. D. D.

    1983-07-01

    Optical metrology of three-dimensional objects is a subject of major interest for science and technology. Several methods have been proposed and research is pursuing on the study of various principles. The method to be described employes a coded illumination of the three-dimensional space by fringes projection and the information of the object is decoded with a moire technique. The principle of the method ranges a large spectrum of applications. The emphasis for practical applications is given on the field of biomedical studies. The analysis of dismorphosises in static (anatomy) and dynamical (functional) situations is presented, in particular for the study of feet-system and locomotor movement, face aesthetic morphology and trunk studies. Capabilities and advantages of the method are described and demonstrated including video recording.

  15. Rural Finance Innovations : Topics and Case Studies

    OpenAIRE

    World Bank

    2005-01-01

    Financial market liberalization, innovations in the area of risk management, and reductions in transaction and supervisory costs have had significant positive impacts on agricultural finance institutions. Building on these positive developments, this study will attempt to contribute ideas based on recent experiences with innovation from developing countries in order to spur more innovations in rural finance. This study focuses on four key areas where innovation could lead to greater access to...

  16. Cooling tower drift: comprehensive case study

    International Nuclear Information System (INIS)

    A comprehensive experiment to study drift from mechanical drift cooling towers was conducted during June 1978 at the PG and E Pittsburg Power Plant. The data from this study will be used for validation of drift deposition models. Preliminary results show the effects of tower geometry and orientation with respect to the wind and to single- or two-tower operation. The effect of decreasing relative humidity during a test run can also be seen

  17. Repowering of wind farms - A case study

    Energy Technology Data Exchange (ETDEWEB)

    Nivedh, B.S. [Quality Engineering and Software Technologies, Bangalore (India); Devi, R.P.K. [College of Engineering. Power Systems Engineering, Guindy (India); Sreevalsan, E. [Gamesa Wind Turbines India Private Limited, Chennai (India)

    2012-07-01

    The main objective of the study is to devise a method for assessing the repowering potential and to improve the energy output from the wind farms and also to understand the impact on the power quality due to repowering. With repowering, the first-generation wind turbines can be replaced with modern multi-megawatt wind turbines. To carry-out the study an old wind farm located at Kayathar, Tamilnadu is selected. The wind farm was commissioned in 1990's with a capacity of 7.35MW, which consists of 36 Wind Turbines each with the capacity of 200kW and 225kW. The present annual energy generation of the wind farm is 7350MWhr with the plant load factor of 11.41%. The intent of this study is to predict the annual energy output of the wind farm after the repowering using WAsP (Wind Atlas Analysis Application Program). Further this study analyses the power quality issues of the various Wind Turbines. In addition, the main feeder, in which the wind farm which is taken for the study also modeled and the impact on power quality due to repowering also studied. Simulations were carried out using MATLAB. The results are analyzed to understand the significance of repowering to overcome the energy crisis of the nation since the best locations for wind in India are occupied by old wind turbines. The following are the observations and conclusions from the above study. Plant load factor (PLF) increased to 24 %, Energy yield increased to more than 4 times and the capacity of the wind farm became double. And in the view of power quality, comparing to the existing Feeder, Repowered Feeder having less reactive power consumption, voltage variations and flickers except the harmonic distortion. (Author)

  18. Building-integrated photovoltaics: A case study

    Energy Technology Data Exchange (ETDEWEB)

    Kiss, G.; Kinkead, J.; Raman, M.

    1995-03-01

    In 1992, Kiss Cathcart Anders Architects performed a study for NREL on Building-Integrated Photovoltaics (BIPV) issues as seen from the perspective of the building community. In general, the purpose of the study was to list major issues and potential applications; by it`s nature it asked more questions than it answered. This second phase study was to produce quantitative data on the performance of specific BIPV systems. Only roof systems are evaluated. The energy performance, construction cost and simple payback for five different BIPV roof options are evaluated in six different locations: Oakland, New York, Miami, Phoenix, Chicago, and Cincinnati. The roof options evaluated include the following: single-glazed PV roof using glass-substrate PVs; double-glazed PV roof with insulating PV modules; ballasted roof-mounted system; sawtooth light monitor roof with indirect north daylighting; sawtooth roof with north light and active heat recovery.

  19. Environmental reference materials methods and case studies

    DEFF Research Database (Denmark)

    Schramm-Nielsen, Karina Edith

    1998-01-01

    . The methods have been evaluated with regard to their robustness towards variations in the chemical analytical method and with regard to the number of times a significant out of control situation is indicated. The second study regards the stability of NH4-N and total phosphorous in autoclaved seawater samples....... This study lasted 22 months as well. The samples were produced and stored according to a 2³ factorial design. The influences of storage temperature, UV radiation and ultra-filtration on the stability of NH4-N and total phosphorous have been investigated. A Youden plot method is suggested for the graphical...

  20. Melasma: A clinicopathological study of 43 cases

    Directory of Open Access Journals (Sweden)

    Sarvjot Vermani

    2009-07-01

    Full Text Available Melasma is a symmetrical hypermelanosis of the exposed skin characterized by brown macules on the sun-exposed areas of the skin. The present study was carried out on 43 patients to analyze the correlation between histopathological features with clinical and Wood′s light examination. The study showed a clinical and histopathological discordance of 16.2%. Solar elastosis (55.8% was the single most common histological finding apart from increased melanin concentration, epidermal flattening and dermal lymphomononuclear inflammation.

  1. Bullous disorders in Konya: A study of 93 cases

    Directory of Open Access Journals (Sweden)

    Munise Daye

    2013-12-01

    Full Text Available Background and Design: Bullous disorders are a group of disorders caused by specific antibodies against tissue adhesion molecules in skin and mucosa or genetic inheritance. There are limited detailed epidemiological studies about bullous disorders in Turkey. In this study we evaluated the demographic, clinical, immunopathologic, course and follow-up properties, cases in Konya. Most of cases were in pemphigus and bullous pemphigoid group, so we gave more information about them. Materials and Methods: Ninty three cases that are followed up during the period of 2006-2012 were included in our study. Results: Female cases were %53,8, male cases were %46,2. The mean age was 52,9. In all of cases; %37,6 cases were pemhigus vulgaris, % 34,4 bullous pemphigoid, %15 herediter epidermolysis bullosa, %4,3 were dermatitis herpetiformis, %4,3 were pemphigus foliaceus, %2,2 pemphigus vegetans, %1,1 Hailey- Hailey disease, %1,1 cicatricial pemphigoid. Mean age of Pemhigus vulgaris onset was 45,9 year and mostly it was observed in females. Pemhigus vulgaris has been started at oral mucosae and the time for diagnosis of pemhigus vulgaris, which began at oral mucosae, was longer than other geogrophic regions. Mean age bullous pemphigoid onset was 70 year and mostly it was observed in females. In % 12,5 of cases disease started at oral mucosae. None of the cases had additional autoimmune disorder. We have treated 25 cases with systemic corticosteriods, 41 cases with systemic corticosteriods and adjuvan agents, 11 cases with only one of adjuvan agents, 16 cases with only local streoids. Conclusions: We report the demographic, clinical, immunopathologic, course and follow-up properties of the bullous disorders in Konya.

  2. The research project KLIMAT. Report of carrot case study; Forskningsprosjektet KLIMAT. Rapport fra gulrot case studie

    Energy Technology Data Exchange (ETDEWEB)

    Svanes, Erik

    2012-07-01

    The research project 'KLIMAT' was 1.1.2009 to 31.8.2012. The main goal of this project was to develop a 'best practice' methodology for quantifying the carbon footprint of products with a focus on fruits, vegetables, dairy and meat products. The methodology was tested on six selected case products. One of these products was the carrot. The product was selected because it is a product with high sales volume, a large part of the production takes place in Norway, and it may be assumed to represent the root vegetables which are a very important group of vegetable products. Oestfold Research, in conjunction with BAMA and Gartnerhallen, collected the necessary data to conduct the study. Data came from a group of 13 producers with ties to Laagendalen that all products supplied to the Laagen Gulrot for processing and packing. The producers were voluntarily affiliated with an online reporting system for a variety of information, including information about resource use that were used in this study. Climate track of carrot packed in the cup was, according to the methodology that was developed 0.39 kg Co2-ekv/kg product delivered to the consumer, 0.44 kg Co2-ekv/kg consumed carrot. (Author)

  3. Exploring Arabidopsis thaliana Root Endophytes via Single-Cell Genomics

    Energy Technology Data Exchange (ETDEWEB)

    Lundberg, Derek; Woyke, Tanja; Tringe, Susannah; Dangl, Jeff

    2014-03-19

    Land plants grow in association with microbial communities both on their surfaces and inside the plant (endophytes). The relationships between microbes and their host can vary from pathogenic to mutualistic. Colonization of the endophyte compartment occurs in the presence of a sophisticated plant immune system, implying finely tuned discrimination of pathogens from mutualists and commensals. Despite the importance of the microbiome to the plant, relatively little is known about the specific interactions between plants and microbes, especially in the case of endophytes. The vast majority of microbes have not been grown in the lab, and thus one of the few ways of studying them is by examining their DNA. Although metagenomics is a powerful tool for examining microbial communities, its application to endophyte samples is technically difficult due to the presence of large amounts of host plant DNA in the sample. One method to address these difficulties is single-cell genomics where a single microbial cell is isolated from a sample, lysed, and its genome amplified by multiple displacement amplification (MDA) to produce enough DNA for genome sequencing. This produces a single-cell amplified genome (SAG). We have applied this technology to study the endophytic microbes in Arabidopsis thaliana roots. Extensive 16S gene profiling of the microbial communities in the roots of multiple inbred A. thaliana strains has identified 164 OTUs as being significantly enriched in all the root endophyte samples compared to their presence in bulk soil.

  4. Development and evaluation of a Gal4-mediated LUC/GFP/GUS enhancer trap system in Arabidopsis

    Directory of Open Access Journals (Sweden)

    Schmuke Jon J

    2005-06-01

    Full Text Available Abstract Background Gal4 enhancer trap systems driving expression of LacZ and GFP reporters have been characterized and widely used in Drosophila. However, a Gal4 enhancer trap system in Arabidopsis has not been described in the primary literature. In Drosophila, the reporters possess a Gal4 upstream activation sequence (UAS as five repeats (5XUAS and lines that express Gal4 from tissue specific enhancers have also been used for the ectopic expression of any transgene (driven by a 5XUAS. While Gal4 transactivation has been demonstrated in Arabidopsis, wide use of a trap has not emerged in part because of the lack of detailed analysis, which is the purpose of the present study. Results A key feature of this study is the use of luciferase (LUC as the primary reporter and rsGFP-GUS as secondary reporters. Reporters driven by a 5XUAS are better suited in Arabidopsis than those containing a 1X or 2X UAS. A 5XUAS-LUC reporter is expressed at high levels in Arabidopsis lines transformed with Gal4 driven by the full, enhanced 35S promoter. In contrast, a minimum 35S (containing the TATA region upstream of Gal4 acts as an enhancer trap system. Luciferase expression in trap lines of the T1, T2, and T3 generations are generally stable but by the T4 generation approximately 25% of the lines are significantly silenced. This silencing is reversed by growing plants on media containing 5-aza-2'-deoxycytidine. Quantitative multiplex RT-PCR on the Gal4 and LUC mRNA indicate that this silencing can occur at the level of Gal4 or LUC transcription. Production of a 10,000 event library and observations on screening, along with the potential for a Gal4 driver system in other plant species are discussed. Conclusion The Gal4 trap system described here uses the 5XUAS-LUC and 5XUAS rsGFP-GUS as reporters and allows for in planta quantitative screening, including the rapid monitoring for silencing. We conclude that in about 75% of the cases silencing is at the level of

  5. Knowledge Management Analysis: A Case Study

    Science.gov (United States)

    Mecha, Ezi I.; Desai, Mayur S.; Richards, Thomas C.

    2009-01-01

    It is imperative for businesses to manage knowledge and stay competitive in the marketplace. Knowledge management is critical and is a key to prevent organizations from duplicating their efforts with a subsequent improvement in their efficiency. This study focuses on overview of knowledge management, analyzes the current knowledge management in…

  6. Case Study - Propane Bakery Delivery Step Vans

    Energy Technology Data Exchange (ETDEWEB)

    Laughlin, M.; Burnham, A.

    2016-04-01

    A switch to propane from diesel by a major Midwest bakery fleet showed promising results, including a significant displacement of petroleum, a drop in greenhouse gases and a fuel cost savings of seven cents per mile, according to a study recently completed by the U.S. Department of Energy's Argonne National Laboratory for the Clean Cities program.

  7. Facebook Groups as LMS: A Case Study

    Science.gov (United States)

    Meishar-Tal, Hagit; Kurtz, Gila; Pieterse, Efrat

    2012-01-01

    This paper describes a pilot study in using Facebook as an alternative to a learning management system (LMS). The paper reviews the current research on the use of Facebook in academia and analyzes the differences between a Facebook group and a regular LMS. The paper reports on a precedent-setting attempt to use a Facebook group as a course…

  8. Case Studies in Continuous Process Improvement

    Science.gov (United States)

    Mehta, A.

    1997-01-01

    This study focuses on improving the SMT assembly process in a low-volume, high-reliability environment with emphasis on fine pitch and BGA packages. Before a process improvement is carried out, it is important to evaluate where the process stands in terms of process capability.

  9. Case Study for Breakwater SSG Application

    DEFF Research Database (Denmark)

    Margheritini, Lucia; Kofoed, Jens Peter

    -u-005, April 2008). The optimization of the structure has been done by maximizing the hydraulic efficiency and used by DMC for relative study on construction and installation. The overall efficiencies have been assessed using the simulation program SSG Power Simulation 2 (Meinert 2006) and used by DMC...

  10. Gender, Class and Rurality: Australian Case Studies

    Science.gov (United States)

    Bryant, Lia; Pini, Barbara

    2009-01-01

    The interrelationship between gender and class in rural spaces has received little attention. While rural scholars have focused on the implications for class from processes of gentrification and agricultural and rural restructuring, these analyses have remained largely ungendered. Similarly, feminist rural studies have rarely explored subjectivity…

  11. Patterned genital injury in cases of rape - A case-control study

    DEFF Research Database (Denmark)

    Astrup, Birgitte Schmidt; Ravn, Pernille; Thomsen, Jørgen Lange;

    2013-01-01

    A pattern of genital injury that separates trauma seen in sexual assault cases from trauma seen following consensual sexual intercourse has been a matter of debate. This study aimed at clarifying the question by eliminating as many confounders as possible in a prospective, case-control setup. A t...

  12. Corporate Social Responsibility : A comparative case study of three companies

    OpenAIRE

    Fadel, Dennis; Dahl, Emil

    2013-01-01

    The main purpose of this thesis is to study why the chosen case companies, Atlas Copco, Sandvik and Alfa Laval engage in CSR activities, with a secondary purpose of investigating how the aformentioned case companies has executed their engagement in CSR and what their present focus is. Our empirical findings suggest that the case companies have similar motives and approaches to CSR engagement. Whereas their main motivation for CSR engagement derives from a concern of legitimacy to their invest...

  13. ML3: a novel regulator of herbivory-induced responses in Arabidopsis thaliana

    OpenAIRE

    Fridborg, I.; Johansson, A; Lagensjo, J.; Leelarasamee, N.; Floková, K. (Kristýna); Tarkowská, D. (Danuše); Meijer, J.; Bejai, S.

    2013-01-01

    ML (MD2-related lipid recognition) proteins are known to enhance innate immune responses in mammals. This study reports the analysis of the putative ML gene family in Arabidopsis thaliana and suggests a role for the ML3 gene in herbivory-associated responses in plants. Feeding by larvae of the Lepidopteran generalist herbivore Spodoptera littoralis and larvae of the specialist herbivore Plutella xylostella activated ML3 transcription in leaf tissues. ML3 loss-of-function Arabidopsis plants we...

  14. Protein Interaction Network of Arabidopsis thaliana Female Gametophyte Development Identifies Novel Proteins and Relations

    OpenAIRE

    Hosseinpour, Batool; HajiHoseini, Vahid; Kashfi, Rafieh; Ebrahimie, Esmaeil; Hemmatzadeh, Farhid

    2012-01-01

    Although the female gametophyte in angiosperms consists of just seven cells, it has a complex biological network. In this study, female gametophyte microarray data from Arabidopsis thaliana were integrated into the Arabidopsis interactome database to generate a putative interaction map of the female gametophyte development including proteome map based on biological processes and molecular functions of proteins. Biological and functional groups as well as topological characteristics of the net...

  15. Dynamic Nucleocytoplasmic Shuttling of an Arabidopsis SR Splicing Factor: Role of the RNA-Binding Domains

    OpenAIRE

    Rausin, Glwadys; Tillemans, Vinciane; Stankovic, Nancy; Hanikenne, Marc; Motte, Patrick

    2010-01-01

    Serine/arginine-rich (SR) proteins are essential nuclear-localized splicing factors. We have investigated the dynamic subcellular distribution of the Arabidopsis (Arabidopsis thaliana) RSZp22 protein, a homolog of the human 9G8 SR factor. Little is known about the determinants underlying the control of plant SR protein dynamics, and so far most studies relied on ectopic transient overexpression. Here, we provide a detailed analysis of the RSZp22 expression profile and describe its nucleocytop...

  16. Plant-microbes interactions : Implication of Phyllobacterium brassicacearum in Arabidopsis responses to water deficit

    OpenAIRE

    Bresson, Justine

    2013-01-01

    Plant growth promoting rhizobacteria (PGPR) can enhance plant performance and plant tolerance to environmental stresses. Arabidopsis thaliana is a useful organism to study the mechanisms involved in plant-PGPR interactions. We analyzed multiple plant traits related to growth dynamics, development and physiology in order to assess the effects of Phyllobacterium brassicacearum STM196 strain, isolated from the rhizosphere of oilseed rape, on Arabidopsis responses to well-defined soil water avail...

  17. Verification of multi-proxy paleoclimatic studies: a case study

    Science.gov (United States)

    McIntyre, S.; McKitrick, R.

    2004-12-01

    ,000 sets of 70 red noise series modeled through fractional difference models to have the same red noise persistence as the critical North American AD1400 tree ring network. These calculations regularly resulted in "hockey-stick" shaped PC1s with sharp inflections at the start of the 20th century. We then modeled the resulting 10,000 PC1s against NH temperature and found that the 99 percent RE significance level was 0.59. By this benchmark, the reported RE statistic (0.51) in MBH98 for the AD1400 step lacks statistical significance. Most dendroclimatic reconstructions also provide statistics other than an RE statistic, including R2 and Coefficient of Efficiency, but MBH98 does not and the authors have refused to provide supporting data from which the statistics can be calculated. In our emulations of their calculations, we have been unable to replicate anything close to the reported RE results other than through re-tuning, a procedure not described in MBH98. With a re-tuning step, for the critical AD1400 step, we have obtained an RE of 0.46, but with an R2 of only 0.02 and a CE of minus 0.26, all of which lack statistical significance. This case study illustrates for extreme caution in basing public policy on articles, such as MBH98, whose claims cannot be verified.

  18. Diabetic hyperosmolality: retrospective study of 60 cases

    OpenAIRE

    Campos, MV; Bastos, M; T. Martins; Leitão, P.; Lemos, MC; Carvalheiro, M; Ruas, A

    2003-01-01

    AIMS AND METHODS: Our aims were to determine the frequency of diabetic hyperosmolality (DH) in our Department, its causes, therapeutic implications and evolution. A five-years retrospective study was performed in 60 patients regarding age, sex, type and duration of diabetes mellitus (DM), previous antidiabetic therapy, underlying diseases, biochemical data, precipitating factors, therapeutic management and outcome. RESULTS: The hyperosmolar coma was responsible for 90% of the metabolic comas ...

  19. Management into design education: a case study

    OpenAIRE

    Daws, Michael; Beacock, Peter

    2005-01-01

    The design project set in a studio learning environment remains central to much of the under- graduate curriculum activity for the aspiring architect. Yet much recent discussion has identified the need to look beyond this design curriculum horizon and to extend into studies in management. The Burton Report, among others, has encouraged diversity in architectural education. A degree course in Architectural Design and Management has been developed at Northumbria University as a direct response ...

  20. Case study examples for Raspberry Pi

    OpenAIRE

    MENEGATTI, OŽBOLT

    2014-01-01

    Wide range of ARM development boards is currently available on the market. Their complexity spans from the simple 8-bit boards to more powerful ones that are also suitable to use as general purpose computers. The most popular ARM board currently available is without any doubt Raspberry Pi. Several study examples that demonstrate its usage are available on the internet. While the input/output devices available in the basic set are very fundamental, these examples are hard to use in the educati...

  1. An exploration study of violence: Mexican case

    OpenAIRE

    Pedro Isnardo De la Cruz; Javier Carreón Guillén

    2013-01-01

    El documento explora, desde la perspectiva sociológica, politológica y psicológica, el estado del arte en el estudio de la violencia, y aborda la estrategia gubernamental de México en su versión asociada al narcotráfico. | The paper explores, from a sociological, political and psychological perspective, the state of the art in the study of violence, addressing the government's strategy in Mexico in the version associated with drug trafficking.

  2. Policy Reform in Egypt? : A case study

    OpenAIRE

    Johansson, Matilda; Nordin, Annelie

    2013-01-01

    This paper studies the police reform in Egypt in the light of the revolution 2011. The ousting of the authoritarian president Hosni Mubarak was the beginning of the transition towards democracy. Within 15 months both parliamentary and presidential election had taken place. The political leaders were new and the transitional process had begun however the institutions where still the same and one feature of the revolution was to reform the police since the police was hated as the oppressive pow...

  3. Measuring financial performance : a case study

    OpenAIRE

    Gjesdal, Frøystein

    2001-01-01

    This paper studies long-term financial performance at the firm level. Fundamentally financial performance measurement is capital budgeting (or valuation) done ex post; expected cash flows and terminal values are replaced by realized or re-estimated flows and/or values. Beginning values may be derived from acquisition costs, opportunity costs or present (market) values at the start of the period. Similar choices must be faced with respect to terminal values. The interpretation of the performan...

  4. A Case Study of Canadian Media Education

    OpenAIRE

    Clarence T. K. Chu

    2005-01-01

    This article uses bibliometric analysis to study the evaluation of journals and researchers in the field of library and information science in Taiwan. For journal evaluation, the results show no statistically significant difference between the rankings of the citations cited by top LIS journals and by THCI journals. This suggests that the citation numbers of top LIS journals can be used to evaluate all the LIS journals. The results also show that the relationship between the rankings of JCR L...

  5. Open Innovation Ecosystem: Chez Panisse Case Study

    OpenAIRE

    Kim, So Hyeong

    2013-01-01

    The concept of open innovation has been highly popularized both in academia and industry for the last decade. Various types of firms have been studied from high tech to service. Yet, there has been limited academic review of open innovation as a collective business ecosystem. In particular, little research exists on how a business ecosystem is generated, how it adopts concepts associated with open innovation in its business practice, and what sustains an ecosystem over time. My dissertatio...

  6. CASE STUDY OF KRESGE FOUNDATION OFFICE COMPLEX

    OpenAIRE

    Goins, John

    2011-01-01

    Most building performance evaluations only describe whether a building meets certain criteria. In contrast, this report describes the performance of the Kresge Foundation Complex (Complex) in relation to industry‐standard design and operations performance criteria while examining the appropriateness of these criteria for the Complex and similar high‐performance buildings. More specifically, this study examines the Complex's performance in 20 areas. It also highlights potential flaws in human ...

  7. Case study of Kresge Foundation office complex.

    OpenAIRE

    Goins, John

    2011-01-01

    Most building performance evaluations only describe whether a building meets certain criteria. In contrast, this report describes the performance of the Kresge Foundation Complex (Complex) in relation to industry‐standard design and operations performance criteria while examining the appropriateness of these criteria for the Complex and similar high‐performance buildings. More specifically, this study examines the Complex's performance in 20 areas. It also highlights potential flaws in human ...

  8. Ossiculoplasty: A Prospective Study of 80 Cases

    Directory of Open Access Journals (Sweden)

    Shrinivas Shripatrao Chavan

    2014-07-01

    Full Text Available Introduction: The use of ossicular graft material in ossicular chain reconstruction has significantly improved hearing results hearing after tympanoplasty and tympanomastoid surgery for chronic otitis media. Today, otologists have a wide array of tools from which to choose, but may find it difficult to know which middle ear implant works best.   Materials and Methods: A prospective study of 80 patients who underwent ossiculoplasty was performed in the ear, nose, and throat (ENT department at a tertiary health care facility from 2011 to 2013. Patients with chronic suppurative otitis media with an air-bone gap (ABG of >25 dB with ossicular involvement were included in the study. Total ossicular replacement prosthesis (TORP, partial ossicular replacement prosthesis (PORP, and refashioned incus were used. Success was defined as ABG   Results: The majority patients were of middle age with moderate conductive hearing loss. Incus was the most susceptible ossicle. Overall success rate in this study was 80.0% with an average change of 15.76 dB in ABG.   Conclusion:  With continuing advances in our understanding of middle ear mechanics, the results of ossiculoplasty are improving and results can be very rewarding in experienced hands. Severity of preoperative ear discharge, preoperative mastoid cellularity, presence of disease, and surgical procedure proved to be significant prognostic factors. Autograft incus and PORP fared better when the malleus handle was present while TORP gave better results when the malleus handle was eroded.  

  9. Stem cell organization in Arabidopsis

    OpenAIRE

    Wendrich, J.R.

    2016-01-01

    Growth of plant tissues and organs depends on continuous production of new cells, by niches of stem cells. Stem cells typically divide to give rise to one differentiating daughter and one non-differentiating daughter. This constant process of self-renewal ensures that the niches of stem cells or meristems stay active throughout plant-life. Specification of stem cells occurs very early during development of the emrbyo and they are maintained during later stages. The Arabidopsis embryo is a hig...

  10. Analysis of Arabidopsis glutathione-transferases in yeast.

    Science.gov (United States)

    Krajewski, Matthias P; Kanawati, Basem; Fekete, Agnes; Kowalski, Natalie; Schmitt-Kopplin, Philippe; Grill, Erwin

    2013-07-01

    The genome of Arabidopsis thaliana encodes 54 functional glutathione transferases (GSTs), classified in seven clades. Although plant GSTs have been implicated in the detoxification of xenobiotics, such as herbicides, extensive redundancy within this large gene family impedes a functional analysis in planta. In this study, a GST-deficient yeast strain was established as a system for analyzing plant GSTs that allows screening for GST substrates and identifying substrate preferences within the plant GST family. To this end, five yeast genes encoding GSTs and GST-related proteins were simultaneously disrupted. The resulting yeast quintuple mutant showed a strongly reduced conjugation of the GST substrates 1-chloro-2,4-dinitrobenzene (CDNB) and 4-chloro-7-nitro-2,1,3-benzoxadiazole (NBD-Cl). Consistently, the quintuple mutant was hypersensitive to CDNB, and this phenotype was complemented by the inducible expression of Arabidopsis GSTs. The conjugating activity of the plant GSTs was assessed by in vitro enzymatic assays and via analysis of exposed yeast cells. The formation of glutathione adducts with dinitrobenzene was unequivocally verified by stable isotope labeling and subsequent accurate ultrahigh-resolution mass spectrometry (ICR-FTMS). Analysis of Arabidopsis GSTs encompassing six clades and 42 members demonstrated functional expression in yeast by using CDNB and NBD-Cl as model substrates. Subsequently, the established yeast system was explored for its potential to screen the Arabidopsis GST family for conjugation of the fungicide anilazine. Thirty Arabidopsis GSTs were identified that conferred increased levels of glutathionylated anilazine. Efficient anilazine conjugation was observed in the presence of the phi, tau, and theta clade GSTs including AtGSTF2, AtGSTF4, AtGSTF6, AtGSTF8, AtGSTF10, and AtGSTT2, none of which had previously been known to contribute to fungicide detoxification. ICR-FTMS analysis of yeast extracts allowed the simultaneous detection and

  11. Case studies: Alligator Rivers Area - ERA experience

    International Nuclear Information System (INIS)

    The Kakadu Region Social Impact Study (KRSIS) was commissioned in 1996 as an outcome of the environmental impact assessment process associated with the proposed Jabiluka uranium mine. The objective of KRSIS was to provide 'a clear statement of aboriginal experiences, values and aspirations regarding development of the region; and a proposed community development programme to enhance and/or mitigate impacts associated with development of the region'. Key stakeholders represented in overseeing the study included the Northern Land Council, the aboriginal community, Energy Resources of Australia (ERA) and the Northern Territory (NT) and Commonwealth governments. The study was jointly funded by the Australian government and Energy Resources of Australia, the mining company owning the Ranger and Jabiluka uranium interests. KRSIS reported on 18 issues of major significance in November 2000 and, while progress has been made in responding to these recommendations, a number have been incorporated into continuing programmes by both the Commonwealth (Federal) and Northern Territory governments. It has been accepted that the township of Jabiru could not remain a closed mining town (the original concept), and the town's future as a regional centre was discussed at a series of community forums. A major issue has been to increase the level of involvement in town development by aboriginal people, especially the traditional landowners. This is also being addressed through specific actions of the Jabiru Sustainability Working Group (JSWG). It was agreed in KRSIS that social impact monitoring should be considered essential in the future. To date, it has proven very difficult to obtain adequate funding for this work, and to determine who or what sort of organization should be in charge of progress in this area. To date, negotiations continue between representatives of the native people and Parks Australia as to what suitable performance indicators there are for social impact monitoring

  12. Assessment of Correspondent Banks Case Study

    Directory of Open Access Journals (Sweden)

    Abeer F.A.A. Abbadi

    2011-01-01

    Full Text Available Problem statement: This study aims at evaluating corresponding banks in Jordan. Characterizing the goals, instruments and profitability under unfavorable conditions of financial setbacks and unfair competition among banks. Focuses on the feasibility and profitability of Philadelphia Investment Bank in its international trade via its Correspondent banks. Approach: Problems and setbacks shall be screened out; reasoned and appropriate optimal recommendations are to be presented. Results: The study followed the analytical approach and depended on “History Documents” and “In depth Interview” techniques and puts a major emphasis on the fact that correspondent banking has become an essential cornerstone of international business amid the new era of world trade, globalization, external competition and cartels from the major opponents to Jordanian Banks, the main conclusion is realized the importance of correspondent banks in the international trade, so Philadelphia bank benefited from correspondent banks for the cheap cost of market entry and services were tailored to the scale of required locale. But there was no big investment in staff facilities. And there are setbacks in dealing with correspondent banks, such as fund delay in reaching destinations on time. Moreover, Jordanian banks have suffered in general from these correspondent banks because they deal with these correspondent banks individually. Conclusion/Recommendations: The recommendation of the study is, it is the time to consider solidification and forming one financial block, or a sort of cartel and face these correspondent banks in one unit. They are also called for developing collective strategies. Small banks should merge and form huge capital blocks. Another strategy is that Jordanian banks should minimize the reliance on foreign banks and should develop their own, by establishing international branches abroad to help financing their international activities.

  13. Temporomandibular disorders. A case-control study

    OpenAIRE

    Poveda-Roda, Rafael; Bagán, Jose V.; Sanchis, Jose M.; Carbonell, Enrique

    2012-01-01

    Objective: To compare the risk factors and clinical manifestations of patients with temporomandibular disorders (TMDs) diagnosed according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) (axis I) versus an age and gender matched control group. Study Design: A total of 162 patients explored according to the RDC/TMD (mean age 40.6±18.8 years, range 7-90; 11.1% males and 88.9% females) were compared with 119 controls, measuring differences in TMD risk factors (sleep...

  14. A STUDY OF EPILEPTIC PSYCHOSES - 150 CASES

    OpenAIRE

    Swamy, H. Satyanarayana; Mallikarjunaiah, M.; Bhatti, Ranbir S.; Kaliaperumal, V.G.

    1986-01-01

    SUMMARY One hundred and fifty patients of epileptic psychosis, registered over a period of five years in neuropsychiatry clinics at NIMHANS were studied. Patients with organic causes which may produce both epilepsy and psychosis were excluded. The epileptic psychosis ratio to epilepsy was 1:23 and the epileptic psychosis ratio to psychosis was 1:75. The mean age at the onset of epilepsy was 19.4 years, while the mean age at the onset of psychosis was 29 years and thus the mean duration of epi...

  15. Case study of establishing a clean production

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yong Kun; Nam, Yoon Mi [Korea Environment Institute, Seoul (Korea)

    1998-12-01

    This study was implemented to derive suggestions for improving policies in Korea through the examination and analysis on the present policies related to the clean production and its establishment in enterprises. The characters of concept on clean production presented in pollution prevention, waste minimization, zero emission, environmental friendly design, and industrial ecology were analyzed and the mechanism for implementing clean production and government policy were arranged comprehensively. The related policies of major countries with international organizations including UNEP (United Nations Environment Program) and EU (European Union) were reviewed and compared to those of Korea to propose future policy plan. 73 refs., 3 figs., 30 tabs.

  16. Reactive membrane technology: Two case studies

    DEFF Research Database (Denmark)

    Zeuner, Birgitte; Luo, Jianquan; Pinelo, Manuel;

    2014-01-01

    Enzymatic processes are generally sustainable processes that use mild conditions and natural substrates. Membrane technology can be employed for enzyme immobilization as well as for recycling free enzymes. Using alcohol dehydrogenase (ADH) as part of a process to recycle CO2 to methanol, we...... investigated the effect of applied pressure, enzyme concentration, pH, and membrane properties on fouling-induced enzyme immobilization. In another study, the production of the human milk oligosaccharide 3’-sialyllactose by an engineered sialidase from Trypanosoma rangeli (Tr6) was significantly improved in an...... enzymatic membrane reactor. The entire process can be improved by employing a series of ultra- and nanofiltrations....

  17. Case Study on Printed Matter in Denmark

    DEFF Research Database (Denmark)

    Larsen, Henrik Fred

    2012-01-01

    2006. A major part of the work has been mapping the presence of chemicals, which are the potential candidates for substitution (e.g., PBT, CMR, vPvB, EDS). The mapping comprises a combination of a literature study and an investigation of the actual (2007) presence of candidate substances at 15 Danish...... printing houses including the examination of almost 900 MSDSs (i.e., products). Furthermore, a focused search in the Danish Product Register has been included. More than 200 of the mapped substances are candidates for substitution according to Danish legislation (List of Undesirable Substances) and about...

  18. Towards Sustainable Building: Case Study on Romania

    Directory of Open Access Journals (Sweden)

    Ana Maria Marinoiu

    2016-06-01

    Full Text Available The purpose of this article is to analyze the actual situation of the green buildings in our country but also the degree in which the real estate developers are involved in such projects. The study was conducted by combining a wide variety of sources, such as regulations, position papers, as well as articles and research reports. The results of the research show that the market for green buildings in Romania is at an early stage of development however, there are prerequisites for its development. In the future, green building will become the standard in the construction industry.

  19. A case study, Bagnoli: a difficult transition

    Directory of Open Access Journals (Sweden)

    Maria Antonietta Selvaggio

    2015-01-01

    In this research work we intend to verify how a particular physical-spatial dimension has influenced the social relations and the same identities of the people and their “community”, how we can delineate the perception and the performance of a urban transformation largely failed, and which contribution the citizens of Bagnoli can give to the urban design through their own imaginary and meanings they ascribe to their environment (Lynch 1960. In this sense, the study aim at giving a contribution to the participative practice, that up to now is out of the transition dynamics.

  20. Multistakeholder as Governance Groups: Observations from Case Studies

    OpenAIRE

    Gasser, Urs; Budish, Ryan Hal; Meyers West, Sarah

    2015-01-01

    This paper synthesizes a set of twelve case studies of real-world governance structures. Together with the underlying case studies, it is the result of a globally coordinated, independent academic research pilot project by the Global Network of Interdisciplinary Internet & Society Research Centers (NoC). Facilitated by the Berkman Center for Internet & Society at Harvard University, this study examines existing multistakeholder governance groups with the goal of informing the evolution of — a...

  1. Economics, Wildlife Tourism and Conservation: Three Case Studies

    OpenAIRE

    Clement A. Tisdell; Wilson, Clevo

    2004-01-01

    SUMMARY This report presents the results of an economics component of the National Interdisciplinary Project (NIP) on wildlife tourism in Australia. Objectives of Study The main objectives of the study were: • to outline and assess the role that economics can play in the valuation and management of wildlife-based tourism; • to undertake appropriate case studies to highlight the value of economics and its limits in assessing wildlife tourism in each case; • given the importance of nature conse...

  2. Fiscal Responsiveness, Persistence and Discretion: A Case Study of Pakistan

    Directory of Open Access Journals (Sweden)

    Syed Ammad

    2012-09-01

    Full Text Available The main objective of this study is to analyses the fiscal policy conditions in Pakistan; in case of output change ( fiscal responsiveness, effect of last year policy on this year( fiscal persistence and finally fiscal discretion, through a 2SLS method the study period consist of 1972 to 2010. The main finding of the study is government expenditures are more responsive in case Pakistan which is the main cause of this fiscal imbalances and also indicating an unstable fiscal stance.

  3. EXPERIENTIAL LEARNING: THE INTERNSHIP AND LIVE-CASE STUDY RELATIONSHIP

    OpenAIRE

    Green, Robert D.; Farideh A. Farazmand

    2012-01-01

    Educators are increasingly using experiential learning pedagogy to improve learning (knowledge and skills). Two highly effective experiential methods are live-case study projects and internships. This study examines the learning outcomes of courses with live-case study projects for students who have had a prior internship experience and those who have not as well as correlation analysis for each group. The results find that prior internship experience does improve applied project learning out...

  4. Case-control study of multiple myeloma and farming.

    OpenAIRE

    Pearce, N E; Smith, A H; Howard, J K; Sheppard, R A; Giles, H J; Teague, C A

    1986-01-01

    A previous case-control study which utilised the occupational information available on the New Zealand Cancer Registry found an increased risk of multiple myeloma in agricultural workers consistent with previous findings in the United States. The findings are now presented for the second phase of the study which involved interviewing 76 cases of multiple myeloma (who had been included in the previous study) together with 315 controls with other types of cancer. The previous finding on an exce...

  5. Factors determining retail banks performance : case study Ubank / Buhle Mdakane

    OpenAIRE

    Mdakane, Buhle

    2012-01-01

    The study is a case study and it investigates the factors that determine the performance of retail banks in South Africa, and follows a case study approach in which Ubank is the focus. The purpose is to rank the identified factors in their order of importance for management's focus on improving the bank's performance. Performance is examined in terms of the bank's profitability and growth. This research utilizes secondary data analysis. The quantitative method is used by critic...

  6. A Psychophysiological Case Study of Orchestra Conductors.

    Science.gov (United States)

    Jaque, S Victoria; Karamanukyan, Isabel H; Thomson, Paula

    2015-12-01

    The psychological and physiological effects of performance were investigated in two professional orchestral conductors, with data collected prior to, during, and after a rehearsal and a public performance. The participants were given a battery of psychological self-report tests (anxiety, dissociation, health inventory, fantasy proneness, shame, and flow). Ambulatory physiological monitoring (Vivometric LifeShirt® system) was conducted during both a rehearsal and public performance to gather information about the autonomic nervous system and heart rate variability (HRV). One conductor had a history of asthma and anxiety, and the second conductor had coronary artery disease. The results revealed within-subject and between-subject differences in autonomic nervous system responses and HRV during several conditions (pre-performance rest, stair-climbing, rehearsal, and performance). Based on heart rate, the physiological demands of professional conducting are reflective of work intensities considered "hard." Both conductors experienced high flow states. Anxiety and coronary artery disease may have attenuated HRV resilience in this study. It is recommended that noninvasive methods be implemented to assess cardiac autonomic activity in professional conductors, particularly during engagement in their professional activities. The findings suggest a need to further study anxiety, respiratory conditions, and cardiovascular risks for conductors. PMID:26614972

  7. Calcium, snails, and birds: a case study

    Directory of Open Access Journals (Sweden)

    R. Mänd

    2000-10-01

    Full Text Available Recent studies have shown that wild birds breeding in acidified areas have difficulties with obtaining sufficient calcium for their eggshells, and that the cause of it is the shortage of land snails. Many birds have to search for Ca-rich snail shells on a daily basis during egg production. Molluscs depend on litter calcium, which has decreased due to acidification of the environment. Calcium limitation may be a widespread phenomenon also in non-acidified, naturally Ca-poor areas. The problem is that while in the latter areas the time for development of specific adaptations may have been sufficient, then in acidified areas, on the contrary, calcium shortage is a recent phenomenon. Therefore, since the extent of calcium limitation in non-acidified areas is hard to derive from observational data, experimental approach is needed. We provide experimental evidence that specific calcium deficit does affect reproductive traits also in the birds breeding in naturally base-poor habitats. Our study was conducted in a heterogeneous woodland area in Estonia containing deciduous forest patches as well as base-poor pine forest with low snail abundance. Ca supplementation, using snail shell and chicken eggshell fragments, was carried out for pied flycatchers and great tits. Extra calcium affected positively several reproductive traits like egg volume and eggshell thickness, start of breeding, and fledglings’ parameters. The negative relationship between calcium availability and lay-date suggests that birds adjust their breeding tactics to conditions of Ca deficiency, for example, by postponing laying.

  8. Case Study - Propane School Bus Fleets

    Energy Technology Data Exchange (ETDEWEB)

    Laughlin, M; Burnham, A.

    2014-08-31

    As part of the U.S. Department of Energy’s (DOE’s) effort to deploy transportation technologies that reduce U.S. dependence on imported petroleum, this study examines five school districts, one in Virginia and four in Texas, successful use of propane school buses. These school districts used school buses equipped with the newly developed liquid propane injection system that improves vehicle performance. Some of the school districts in this study saved nearly 50% on a cost per mile basis for fuel and maintenance relative to diesel. Using Argonne National Laboratory’s Alternative Fuel Life-Cycle Environmental and Economic Transportation (AFLEET) Tool developed for the DOE’s Clean Cities program to help Clean Cities stakeholders estimate petroleum use, greenhouse gas (GHG) emissions, air pollutant emissions and cost of ownership of light-duty and heavy-duty vehicles, the results showed payback period ranges from 3—8 years, recouping the incremental cost of the vehicles and infrastructure. Overall, fuel economy for these propane vehicles is close to that of displaced diesel vehicles, on an energy-equivalent basis. In addition, the 110 propane buses examined demonstrated petroleum displacement, 212,000 diesel gallon equivalents per year, and GHG benefits of 770 tons per year.

  9. Qualitative methodology in a psychoanalytic single case study

    DEFF Research Database (Denmark)

    Grünbaum, Liselotte

    This study concerns the systematic integration of qualitative research strategies in a psychoanalytic single case study of a child who had suffered early abuse and neglect. A systematic exploration of core features of the therapeutic relationship was carried out, possible links between such core...... with Interpretational Phenomenological Analysis were applied on recorded session notes and other case-file material from a concluded child psychotherapy case as well as on transcripts from follow-up interviews with the child’s birth and foster parents. The case material analyzed in three steps; principles...... for transparent selection developed: 1) Inductive exploration highlighting core object relationship themes in the first 24 therapy sessions. 2) Predefined manifestations of these themes systematically studied in case file reports from various informants about the child’s infancy, daily life, at end of therapy...

  10. Dyslipidemia and Psoriasis: A Case Control Study

    International Nuclear Information System (INIS)

    Objective: To evaluate and compare the effects of pre-operative single oral dose of tramadol and famotidine on gastric secretions pH and volume in patients electively scheduled for laparoscopic cholecystectomy. Study Design:Randomized control trial. Place and Duration of Study: Department of Anaesthesia, King Saud University Riyadh, Saudi Arabia, from August 2011 to June 2013. Methodology:Ninety adult, ASA-I and II patients scheduled for laparoscopic cholecystectomy were included in the study. Patients were randomly assigned to receive pre-operatively either placebo (Group-C, n=30), oral tramadol 100 mg (Group-T, n=30) or famotidine 40 mg (Group-F, n=30). After induction of general anaesthesia, gastric fluid was aspirated through orogastric tube. The gastric secretions volume and pH was measured using pH meter. Results: There was no statistically difference between groups in age, weight and gender. The gastric secretions mean pH was 2.06 ± 0.22,2.04 ± 0.20, 5.79 ± 0.77 and volume was 0.59 ± 0.17, 0.59 ± 0.14 and 0.28 ± 0.16 ml/kg in Group-C, Group-T and Group-F respectively. There was a significant statistical difference in the mean pH values between Group-C vs. Group-F (p greater than 0.001) and Group-Tvs. Group-F (p greater than 0.001). Statistically significant difference was also found in the mean gastric secretions volume between Group - C vs. Group-F (p greater than 0.001) and Group-Tvs. Group-F (p greater than 0.001). There was no significant difference in the mean gastric fluid pH values (p=0.99) and mean gastric secretions volume (p=0.99) between Group-T and Group-C. Conclusion:As compared to famotidine, pre-operative single oral dose of tramadol was unable to elevate the desired level of gastric fluid pH (less than 2.5) and decrease in gastric secretions volume (greater than 0.4ml/kg). (author)

  11. Case Study Report #17. Franklin and Andrea White Deer.

    Science.gov (United States)

    Myers, Douglas D.; And Others

    This document presents one in a series of twenty-three case studies derived from in-depth interviews using a sampling of former participants in the Mountain-Plains program, a residential, family-based education program developed to improve the economic potential and lifestyle of selected student families in a six-state area. Each case study…

  12. Regional heritage preservation planning :an examination through case study analysis

    OpenAIRE

    Hardy, Karen J.

    1993-01-01

    Cultural preservation efforts have evolved from traditional, site specific projects administered by a single agency, to regional, multi-jurisdictional projects administered by a cooperative partnership. The projects administered cooperative partnerships are a recent phenomena and are often termed heritage preservation projects. An analysis of the evolution of cultural preservation efforts is undertaken through historical and case study research. The selected cases are ...

  13. PEM Electrolysis H2A Production Case Study Documentation

    Energy Technology Data Exchange (ETDEWEB)

    James, Brian [Strategic Analysis Inc. (SA), Arlington, Virginia; Colella, Whitney [Strategic Analysis Inc. (SA), Arlington, Virginia; Moton, Jennie [Strategic Analysis Inc. (SA), Arlington, Virginia; Saur, G. [Strategic Analysis Inc. (SA), Arlington, Virginia; Ramsden, T. [Strategic Analysis Inc. (SA), Arlington, Virginia

    2013-12-31

    This report documents the development of four DOE Hydrogen Analysis (H2A) case studies for polymer electrolyte membrane (PEM) electrolysis. The four cases characterize PEM electrolyzer technology for two hydrogen production plant sizes (Forecourt and Central) and for two technology development time horizons (Current and Future).

  14. Evaluating a Tacit Knowledge Sharing Initiative: A Case Study

    Science.gov (United States)

    Gubbins, Claire; Corrigan, Siobhan; Garavan, Thomas N.; O'Connor, Christy; Leahy, Damien; Long, David; Murphy, Eamonn

    2012-01-01

    Purpose: This paper aims to present a case study illustrating the issues involved in the tacit knowledge conversion process and to determine whether such conversion delivers value to the organisation in terms of business value and return on investment (ROI). Design/methodology/approach: A single-case multiple baseline participants experimental…

  15. Active learning of statistics: a case study

    Directory of Open Access Journals (Sweden)

    Erica J. Morris

    2000-12-01

    Full Text Available Students studying psychology or a social science have to take courses in statistics, but students often experience difficulties in learning statistical concepts and techniques. Indeed, there is a body of interdisciplinary research that indicates that students tend to have confusions and difficulties with a variety of topics in statistics (Garfield and Ahlgren, 1988; Shaughnessy, 1992. It has been found that students hold misconceptions relating to fundamental statistical concepts, such as the mean and correlation (Mevarech, 1983; Morris, 1997. Research in computer-based learning has looked at how the computer can be used effectively to address students' statistical misconceptions and help students come to understand key statistical ideas (Cumming and Thomason, 1995; Morris, 1998.

  16. Case study on ground water flow (8)

    International Nuclear Information System (INIS)

    The report comprises research activities made in fiscal year 1997 under the contract of Japan Nuclear Fuel Cycle Development Center and the main items are: (1) Evaluation of water permeability through discontinuous hard bedrock in deep strata in relevant with underground disposal of radioactive wastes, (2) Three dimensional analysis of permeated water in bedrock, including flow analysis in T ono district using neuro-network and modification of Evaporation Logging System, (3) Development of hydraulic tests and necessary equipment applicable to measurements of complex dielectric constants of contaminated soils using FUDR-V method, this giving information on soil component materials, (4) Investigation methods and modeling of hydraulics in deep strata, (5) Geological study of ground water using environmental isotopes such as 14C, 36Cl and 4He, particularly measurement of ages of ground water using an accelerator-mass spectrometer, and (6) Re-submerging phenomena affecting the long-term geological stability. (S. Ohno)

  17. Case study on ground water flow (8)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-02-01

    The report comprises research activities made in fiscal year 1997 under the contract of Japan Nuclear Fuel Cycle Development Center and the main items are: (1) Evaluation of water permeability through discontinuous hard bedrock in deep strata in relevant with underground disposal of radioactive wastes, (2) Three dimensional analysis of permeated water in bedrock, including flow analysis in T ono district using neuro-network and modification of Evaporation Logging System, (3) Development of hydraulic tests and necessary equipment applicable to measurements of complex dielectric constants of contaminated soils using FUDR-V method, this giving information on soil component materials, (4) Investigation methods and modeling of hydraulics in deep strata, (5) Geological study of ground water using environmental isotopes such as {sup 14}C, {sup 36}Cl and {sup 4}He, particularly measurement of ages of ground water using an accelerator-mass spectrometer, and (6) Re-submerging phenomena affecting the long-term geological stability. (S. Ohno)

  18. Mapping Regional Drought Vulnerability: a Case Study

    Science.gov (United States)

    Karamouz, M.; Zeynolabedin, A.; Olyaei, M. A.

    2015-12-01

    Drought is among the natural disaster that causes damages and affects many people's life in many part of the world including in Iran. Recently, some factors such as climate variability and the impact of climate change have influenced drought frequency and intensity in many parts of the world. Drought can be divided into four categories of meteorological, hydrological, agricultural and social-economic. In meteorological the important feature is lack of rainfall. In hydrological drought river flows and dam storage are considered. Lack of soil moisture is the key factor in agricultural droughts while in social-economic type of drought the relation between supply and demand and social-economic damages due to water deficiency is studied. While the first three types relates to the lack of some hydrological characteristics, social-economic type of drought is actually the consequence of other types expressed in monetary values. Many indices are used in assessing drought; each has its own advantages and disadvantages and can be used for specific types of drought. Therefore knowing the types of drought can provide a better understanding of shortages and their characteristics. Drought vulnerability is a concept which shows the likelihood of damages from hazard in a particular place by focusing on the system status prior to the disaster. Drought vulnerability has been viewed as a potential for losses in the region due to water deficiency at the time of drought. In this study the application of vulnerability concept in drought management in East Azarbaijan province in Iran is investigated by providing vulnerability maps which demonstrates spatial characteristics of drought vulnerability. In the first step, certain governing parameters in drought analysis such as precipitation, temperature, land use, topography, solar radiation and ground water elevation have been investigated in the region. They are described in details and calculated in suitable time series. Vulnerabilities

  19. biochemical and hormonal studies in obese cases

    International Nuclear Information System (INIS)

    The present study was carried out on a total number of 116 obese and 23 non-obese control females. Obesity was assessed mainly by body mass index (BMI). Other skinfold thickness e.g. triceps, subscapular, suprailiac, as parameters of obesity assessment were determined in some obese patients. The degree of obesity was assessed by BMI and categorized as follows: i- Mild obesity, BMI=25-30 Kg/m2. ii-Moderate obesity, BMI=31-35 kg/m2. iii-severe obesity, BMI= above 35 kg/m2. Type of fat distribution was assessed by waist/hip circumference ratio (w/H) as :- i-gynoid (lower body segment obesity). (≤ 0.81) i i- android (upper body segment obesity). (≥0.82)

  20. MAPPING REGIONAL DROUGHT VULNERABILITY: A CASE STUDY

    Directory of Open Access Journals (Sweden)

    M. Karamouz

    2015-12-01

    Full Text Available Drought is among the natural disaster that causes damages and affects many people’s life in many part of the world including in Iran. Recently, some factors such as climate variability and the impact of climate change have influenced drought frequency and intensity in many parts of the world. Drought can be divided into four categories of meteorological, hydrological, agricultural and social-economic. In meteorological the important feature is lack of rainfall. In hydrological drought river flows and dam storage are considered. Lack of soil moisture is the key factor in agricultural droughts while in social-economic type of drought the relation between supply and demand and social-economic damages due to water deficiency is studied. While the first three types relates to the lack of some hydrological characteristics, social-economic type of drought is actually the consequence of other types expressed in monetary values. Many indices are used in assessing drought; each has its own advantages and disadvantages and can be used for specific types of drought. Therefore knowing the types of drought can provide a better understanding of shortages and their characteristics. Drought vulnerability is a concept which shows the likelihood of damages from hazard in a particular place by focusing on the system status prior to the disaster. Drought vulnerability has been viewed as a potential for losses in the region due to water deficiency at the time of drought. In this study the application of vulnerability concept in drought management in East Azarbaijan province in Iran is investigated by providing vulnerability maps which demonstrates spatial characteristics of drought vulnerability. In the first step, certain governing parameters in drought analysis such as precipitation, temperature, land use, topography, solar radiation and ground water elevation have been investigated in the region. They are described in details and calculated in suitable time

  1. Urban pest management. A Madrid case study

    Directory of Open Access Journals (Sweden)

    Ibon Tamayo Uria

    2013-06-01

    Full Text Available Citizens’ reports of sightings of undesirable animals are a common component of pest control programmes in a city. For this reason, local authorities tend to develop procedures for the capture and analysis of the resulting data sets based on these reported sightings. These procedures in turn contribute to the development of other initiatives aimed at improving public health conditions. The study presented here focuses on the methodology designed and implemented by the Madrid City Council for controlling and managing the presence of urban pests.The long experience (over 100 years of the City Council and its commitment to the incorporation of new technologies have allowed a number of important lessons to be learnt in pest control and management, which may be useful as a guide and model for cities where public health services have not yet incorporated these methods.

  2. Interactive verification of Markov chains: Two distributed protocol case studies

    Directory of Open Access Journals (Sweden)

    Johannes Hölzl

    2012-12-01

    Full Text Available Probabilistic model checkers like PRISM only check probabilistic systems of a fixed size. To guarantee the desired properties for an arbitrary size, mathematical analysis is necessary. We show for two case studies how this can be done in the interactive proof assistant Isabelle/HOL. The first case study is a detailed description of how we verified properties of the ZeroConf protocol, a decentral address allocation protocol. The second case study shows the more involved verification of anonymity properties of the Crowds protocol, an anonymizing protocol.

  3. Case studies in intelligent computing achievements and trends

    CERN Document Server

    Issac, Biju

    2014-01-01

    Although the field of intelligent systems has grown rapidly in recent years, there has been a need for a book that supplies a timely and accessible understanding of this important technology. Filling this need, Case Studies in Intelligent Computing: Achievements and Trends provides an up-to-date introduction to intelligent systems.This edited book captures the state of the art in intelligent computing research through case studies that examine recent developments, developmental tools, programming, and approaches related to artificial intelligence (AI). The case studies illustrate successful ma

  4. Single case studies as a means for developing psychological theories.

    Science.gov (United States)

    Skvortsov, Anatoliy; Romashchuk, Alexander

    2015-12-01

    The Socratic function of single case studies (SCSs) is described in its relation to the problem of scientific theory development. Contrary to the traditional point of view, the single case study is not a demonstration or verification of theoretical concepts, but a method of their generation and opportunity for analysis of their interrelations. Considering the case study from the perspective of the Socratic function brings to light important conclusions about the ecological validity of theory development. The essential features of the Socratic function are illustrated using the example of the famous Romantic Essays of Alexandr Luria. PMID:26663629

  5. The Case of the "Tainted" Taco Shells: A Case Study on Genetically Modified Foods

    Science.gov (United States)

    Taylor, Ann T. S.

    2004-01-01

    This case study introduces students to the use of genetically modified foods. Students learn how genetically modified plants are made, and then they read primary literature papers to evaluate the environmental, economic, and health issues. (Contains 2 figures.)

  6. SCMAI Case Report: Librarians in Faculty Unions--A Case Study.

    Science.gov (United States)

    Marko, Lynn

    1979-01-01

    The problems of librarians in faculty unions in relation to status, salary, and salary calculation are covered in this case study brought before the American Library Association Staff Committee on Mediation, Arbitration, and Inquiry (SCMAI) in 1977. (Author/MBR)

  7. A parathyroid adenoma case study: Protocol review

    International Nuclear Information System (INIS)

    Full text: Technetium-99m (99mTc) Sestamibi as opposed to Thallous-201 Chloride and 99mTc Sodium Pertechnetate subtraction, has become the radiopharmaceutical of choice for detection of parathyroid adenomas. A 17-year-old female patient presented to the department for a parathyroid 99mTc Sestamibi scan to evaluate possible parathyroid adenoma/s. She was initially admitted with increasing serum Calcium levels, polyuria, abdominal pain and general malaise. The patient was injected with 900MBq of 99mTc Sestamibi, and a pinhole dynamic at a distance of 10 cm from the neck was acquired followed by a 5-minute static image at 7 cm. Single Photon Emission Computed Tomography (SPECT) was then performed on a dual-head gamma camera followed by an anterior and posterior 10-minute static image. At 3 and 5 hours post injection the 10-minute static image was repeated. This study was reported as normal with uniform uptake and washout of the tracer over the 5-hour period. An ultrasound study was performed, and it showed a lesion believed to be a parathyroid adenoma measuring 2.2 x 0.8 x 0.4 cm in size in the right upper lobe of the thyroid. A subsequent thyroid scan was performed to confirm that it was non-functioning thyroid tissue. The patient was injected with 250MBq of 99mTc Sodium Pertechnetate and scanned with a pinhole collimator at a distance of 7 cm. When the 99mTc Sestamibi and 99mTc Sodium Pertechnetate scan were viewed together, it was clear that there was excess 99mTc Sestamibi distribution on the right upper lobe of the thyroid, which washed out over time. This corresponded to the ultrasound findings and was confirmed at surgery to be a parathyroid adenoma. A 99mTc Sodium Pertechnetate scan and an ultrasound are now also routinely performed on patients presenting for 99mTc Sestamibi parathyroid scans

  8. Preventive maintenance by vibratory analysis: case study

    Directory of Open Access Journals (Sweden)

    Amal Boukili,

    2015-08-01

    Full Text Available :The majority of the industrial machine components have to satisfy to the requirements of the high quality and incessantly increasing; so the machines maintaining in good state during the production has became a fundamental point for a product or a company success. Through the measure of the predictive maintenance, it is possible to satisfy these complex requirements with success and to reduce the costs of maintenance. However, an optimization of the maintenance is realized by a continued monitoring of degradation, by way of a control system on line “On Line”, which can respond to industrial imperatives and which provides to define just the necessary at the level of interventions, “The machine can’t be serviced except if only its state requires.”For an effective maintenance, it takes precise and reliable measures. Nevertheless, the experience has shown that the vibratory measure is the most reliable parameter that gives the precociously and with a best ways the deterioration state of a turnable machine. It provides to identify the efforts as soon as they appear, before of an irreversible damage, it also provides, after analysis, to deduce the origin and to estimate the breakdown risks.In this context, a study had done inside a workshop of a phosphoric office, which adopt a continued surveillance (On-Line, in the hope of doing an optimal process of a conditional maintenance which can be developed in time toward an idealized by a vibratory indicator accomplishing satisfactory results.

  9. Mental Toughness among Footballers: A Case Study

    Directory of Open Access Journals (Sweden)

    M.S. Omar-Fauzee

    2012-01-01

    Full Text Available The purpose of this study is to examine the mental toughness perceived by selected the National football players. A sample of twelve Malaysian footballers (current and ex-players, aged 19 to 57 years old agreed to participate. All of them have been playing in the Malaysia National Football League that consists of four former national footballers, four former state footballers and four currently active footballers. Among them, five individuals are active as a coach. A semi-structure interview scheduled was used in the research. All of the respondents have signed the informed consent letter for tape-recorded during the interviewed. The transcribed verbatim from the tapes were content analyzed by the authors to identify the themes. Results show that eight themes emerged from the interviews, which are motivation, negative energy, self-confidence, positive energy, visual and imagery control, patriotic spirit, perseverance and attention control. Almost all of the themes have been identified by previous researchers (i.e., Fourie & Potgieter, 2001; Jones, Hanton & Connoughton, 2002; 2007; and Loehr, 1986, except for patriotic and perseverance. Recommendations for further research also suggested.

  10. Deltoid contracture: A study of nineteen cases

    Directory of Open Access Journals (Sweden)

    Banerji Debabrata

    2008-01-01

    Full Text Available Objective: Deltoid contracture is not uncommon in India. Contractures of deltoid often do not have definite etiology. We have critically analyzed the condition as regards the etiopathogenesis and its surgical results. Materials and Methods: Nineteen patients with deltoid contracture operated between June 1990 and September 2001 were enrolled for a unicentric retrospective study. The surgery was indicated in patients with abduction deformity of more than 30° at the shoulder. The etiology of deltoid contracture was idiopathic ( n = 13 intramuscular injection in deltoid muscle ( n = 5 and blunt trauma ( n = 1. All were operated by distal release (incision near the insertion of the deltoid muscle. The average follow-up was of 9.5 years (range 6-17 years. They were evaluated based on parameters like pain, persistence of deformity, range of shoulder movements and strength of deltoid. Results: All patients recovered painless full range of shoulder motion except one. The correction of deformity was achieved in all patients and there was no loss of strength of deltoid compared to the opposite side. Histology of excised tissue showed features of chronic inflammation. The complications observed were hypertrophic scar ( n = 1, painful terminal restriction of shoulder movements ( n = 1 and prominent vertebral border of scapula ( n = 1. Conclusion: Deltoid contracture has features of chronic inflammation, and the intramuscular deltoid injection is the most incriminating factor in its etiopathogenesis. The condition can be effectively managed surgically by distal release of the deltoid muscle combined with excision of the muscular fibrotic contracture band.

  11. Case study: Managing potentially contaminated records

    International Nuclear Information System (INIS)

    For the past 10 or more years, Analytical Laboratory data cards have been generated and stored in the 222-S Laboratory at the Hanford Site in Richland, Washington. These cards are classified as record material and require retention for a minimum of 75 years in an approved storage facility in accordance with Westinghouse Hanford Company procedures. The cards are maintained in records boxes in the attic of the 222-S Laboratory and are subject to potential risk and loss. The most significant potential risks are radiological hazards. Various options are available for removal, cataloging, transmittal, and storage of these long-term records. Because the records are currently stored in a radiation protection zone, they surveyed before being released from the facility. This survey can be arduous and time consuming. Resolutions to the problem of removal and proper storage of the records from the facility need to be addressed. The records were reviewed and inventoried to determine the quantity of information. A study of the various options available was conducted, and based on the information collected, it was determined that the most feasible and cost-effective approach is to microfilm the cards inside the laboratory. This option complies with all applicable company requirements and decreases the estimated radiological survey time from approximately 3.5 years to under 40 hours. This activity will result in a potential savings of $350,000 over the life of the activity

  12. Case study: Natural bodybuilding contest preparation.

    Science.gov (United States)

    Kistler, Brandon M; Fitschen, Peter J; Ranadive, Sushant M; Fernhall, Bo; Wilund, Kenneth R

    2014-12-01

    The purpose of this study was to document the physiological changes that occur in a natural bodybuilder during prolonged contest preparation for a proqualifying contest. During the 26-week preparation, the athlete undertook a calorically restrictive diet with 2 days of elevated carbohydrate intake per week, increased cardiovascular (CV) training, and attempted to maintain resistance-training load. The athlete was weighed twice a week and body composition was measured monthly by DXA. At baseline and every 2 weeks following CV structure and function was measured using a combination of ultrasound, applanation tonometry, and heart rate variability (HRV). Cardiorespiratory performance was measured by VO(2)peak at baseline, 13 weeks, and 26 weeks. Body weight (88.6 to 73.3 Kg, R(2) = .99) and percent body fat (17.5 to 7.4%) were reduced during preparation. CV measurements including blood pressure (128/61 to 113/54 mmHg), brachial pulse wave velocity (7.9 to 5.8m/s), and measures of wave reflection all improved. Indexed cardiac output was reduced (2.5 to 1.8L/m(2)) primarily due to a reduction in resting heart rate (71 to 44 bpm), and despite an increase in ejection faction (57.9 to 63.9%). Assessment of HRV found a shift in the ratio of low to high frequency (209.2 to 30.9%). Absolute VO2 was minimally reduced despite weight loss resulting in an increase in relative VO2 (41.9 to 47.7 ml/Kg). In general, this prolonged contest preparation technique helped the athlete to improve body composition and resulted in positive CV changes, suggesting that this method of contest preparation appears to be effective in natural male bodybuilders. PMID:24901578

  13. Servant Leadership through Distance Learning: A Case Study

    Science.gov (United States)

    Russell, Eric James

    2013-01-01

    This qualitative study explored the influence a distance learning servant leadership course had on the emergency service students' understanding of leadership. The research study utilized a case study design in order to tell the story of the lived experiences of the participants. The setting for the study was a state university in Utah, with…

  14. An International Bioinformatics Infrastructure to Underpin the Arabidopsis Community

    Science.gov (United States)

    The future bioinformatics needs of the Arabidopsis community as well as those of other scientific communities that depend on Arabidopsis resources were discussed at a pair of recent meetings held by the Multinational Arabidopsis Steering Committee (MASC) and the North American Arabidopsis Steering C...

  15. Immigrants: A Study Case for N. Greece

    Directory of Open Access Journals (Sweden)

    Maria Vlachadi

    2014-05-01

    Full Text Available It is a fact that the phenomenon of immigration constitutes, during the last years, the view of a new social and economic reality for the societies of most western European countries. Greece has received for the first time, during the 1990s, thousands of economic immigrants who appear not only in the big city centers but also in small country towns. Immigrants probably constitute the most discussed issue in the Modern Greek society, in an economic conjuncture in which the economic crisis has functioned in a catalytic way for the diffusion of insecurity in the native population (Biblionet, 2012. The Greek state was not ready to accept such a large number of immigrants in so little time. It showed hesitance and could not keep a steady position as far as the promotion of a necessary institutional framework for their integration in the Greek society was concerned. This initial surprise has never been overcome. In Greece, as well as in the rest of the European South, the majority of the immigrants entering the country illegally have supplied the informal working market. Even when they become legal, the available working positions for them presuppose low specialization with low payments, hard work and limited opportunities of improvement of their social and occupational status. Although the immigration phenomenon is usually approached in a national level, the local level is considered the most suitable one to deal with the interaction of its economic, social, political and cultural dimensions. Recent studies have shown their positive contribution in the revival of Greek agriculture and Greek agricultural districts in general. Within the scale of the Greek community and the degree in which it constitutes a place of constant flow of human resources, it is inevitable the general presence of immigrants to raise issues of mutual infiltrations among different national populations within which there arise interaction issues and intercultural interdependence

  16. Arabidopsis CDS blastp result: AK106750 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK106750 002-115-C09 At4g15560.1 1-deoxy-D-xylulose 5-phosphate synthase, putative / 1-deoxyxylu ... phate synthase, putative / DXP-synthase, putative (DEF ) (CLA1) identical to SP|Q38854 Probable 1-deoxy-D- ... (DXPS). [Mouse-ear cress] {Arabidopsis thaliana}, DEF ... (def icient in photosynthesis) protein [Arabidopsis ...

  17. Arabidopsis CDS blastp result: AK104851 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK104851 001-043-A10 At4g15560.1 1-deoxy-D-xylulose 5-phosphate synthase, putative / 1-deoxyxylu ... phate synthase, putative / DXP-synthase, putative (DEF ) (CLA1) identical to SP|Q38854 Probable 1-deoxy-D- ... (DXPS). [Mouse-ear cress] {Arabidopsis thaliana}, DEF ... (def icient in photosynthesis) protein [Arabidopsis ...

  18. Arabidopsis CDS blastp result: AK100909 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK100909 J023132G24 At4g15560.1 1-deoxy-D-xylulose 5-phosphate synthase, putative / 1-deoxyxylul ... phate synthase, putative / DXP-synthase, putative (DEF ) (CLA1) identical to SP|Q38854 Probable 1-deoxy-D- ... (DXPS). [Mouse-ear cress] {Arabidopsis thaliana}, DEF ... (def icient in photosynthesis) protein [Arabidopsis ...

  19. Arabidopsis CDS blastp result: AK058950 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK058950 001-020-A07 At4g15560.1 1-deoxy-D-xylulose 5-phosphate synthase, putative / 1-deoxyxylu ... phate synthase, putative / DXP-synthase, putative (DEF ) (CLA1) identical to SP|Q38854 Probable 1-deoxy-D- ... (DXPS). [Mouse-ear cress] {Arabidopsis thaliana}, DEF ... (def icient in photosynthesis) protein [Arabidopsis ...

  20. Arabidopsis CDS blastp result: AK059821 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK059821 006-205-D11 At4g15560.1 1-deoxy-D-xylulose 5-phosphate synthase, putative / 1-deoxyxylu ... phate synthase, putative / DXP-synthase, putative (DEF ) (CLA1) identical to SP|Q38854 Probable 1-deoxy-D- ... (DXPS). [Mouse-ear cress] {Arabidopsis thaliana}, DEF ... (def icient in photosynthesis) protein [Arabidopsis ...

  1. Arabidopsis CDS blastp result: AK064944 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK064944 J013000P14 At4g15560.1 1-deoxy-D-xylulose 5-phosphate synthase, putative / 1-deoxyxylul ... phate synthase, putative / DXP-synthase, putative (DEF ) (CLA1) identical to SP|Q38854 Probable 1-deoxy-D- ... (DXPS). [Mouse-ear cress] {Arabidopsis thaliana}, DEF ... (def icient in photosynthesis) protein [Arabidopsis ...

  2. Arabidopsis CDS blastp result: AK068400 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK068400 J013151M04 At3g45810.1 ferric reductase-like transmembrane component family protein sim ... ilar to respiratory burst ... oxidase protein D RbohD from Arabidopsis thaliana, ... EMBL:AF055357 [gi:3242789], similar to respiratory burst ... oxidase protein D RbohD from Arabidopsis thaliana, ...

  3. Arabidopsis CDS blastp result: AK066013 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK066013 J013047I12 At3g45810.1 ferric reductase-like transmembrane component family protein sim ... ilar to respiratory burst ... oxidase protein D RbohD from Arabidopsis thaliana, ... EMBL:AF055357 [gi:3242789], similar to respiratory burst ... oxidase protein D RbohD from Arabidopsis thaliana, ...

  4. Arabidopsis CDS blastp result: AK100241 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK100241 J023054P13 At3g45810.1 ferric reductase-like transmembrane component family protein sim ... ilar to respiratory burst ... oxidase protein D RbohD from Arabidopsis thaliana, ... EMBL:AF055357 [gi:3242789], similar to respiratory burst ... oxidase protein D RbohD from Arabidopsis thaliana, ...

  5. Arabidopsis CDS blastp result: AK318553 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK318553 J075145A22 At3g45810.1 68416.m04958 ferric reductase-like transmembrane component famil ... y protein similar to respiratory burst ... oxidase protein D RbohD from Arabidopsis thaliana, ... EMBL:AF055357 [gi:3242789], similar to respiratory burst ... oxidase protein D RbohD from Arabidopsis thaliana, ...

  6. Using "Arabidopsis" Genetic Sequences to Teach Bioinformatics

    Science.gov (United States)

    Zhang, Xiaorong

    2009-01-01

    This article describes a new approach to teaching bioinformatics using "Arabidopsis" genetic sequences. Several open-ended and inquiry-based laboratory exercises have been designed to help students grasp key concepts and gain practical skills in bioinformatics, using "Arabidopsis" leucine-rich repeat receptor-like kinase (LRR RLK) genetic…

  7. Comparative Study on Effects of Low Energy N+ Implantation and γ-ray Radiation on Heredity and Development of Arabidopsis Thaliana

    Institute of Scientific and Technical Information of China (English)

    Zhang Genfa; Li Ke; Shi Xiaoming; Nie Yanli; Zhang Jun; Zhou Hongyu; Lu Ting

    2005-01-01

    In order to compare the contemporary and genetic variation effect on Arabidopsis thaliana treated with N+ implantation and γ-ray radiation, the authors did some statistical comparison on the germinating rate and the development period, and analyzed the content of soluble proteins, the activity of some enzymes, isoenzymes profile, and along with the variation in genome DNA of two generations by RAPD. With N+ implantation there was an analogical "saddle model" relationship between doses and the plant development, soluble proteins, the activity of some enzymes and isoenzymes profile. A certain connection might exist between the similar dose-effect relations among enzymes activity, isoenzymes profile and content of soluble proteins.Maybe, there also exists a certain connection between the mutants of development period and that of DNA variations, between the hereditability of the effect of N+ implantation on the isoenzymes,the activities of enzymes and the hereditability of DNA variations. So it is presumed that the implanted ions, maybe, have participated in metabolism process of organism including that of genome DNA, to consequently affect vital process, such as the changes of gene structure, gene expression manner and gene repair mechanism, and finally result in mutation on phenotype and molecular level. Furthermore, the results definitely showed that mutagenic mechanism induced by N+ implantation is very complicated and is much different from that induced by traditional γ-ray radiation.

  8. Tephrochronology: a New Zealand case study

    Science.gov (United States)

    Shane, Phil

    2000-03-01

    Tephrochronology is the study of volcanic ash (tephra) beds for the purpose of correlating and dating volcanic and other geologic events. Large magnitude silicic eruptions can disperse tephra up to thousands of kilometres from the vent, producing a near instantaneous marker horizon. In addition to their geochronological value, tephra beds are a major source of data on the eruption frequency and geochemistry of large rhyolitic volcanoes. The Quaternary Taupo volcanic zone (TVZ) in New Zealand is one of the most frequently active rhyolitic centres on Earth, and for much of the 20th century its tephra beds have been the focus of study. As a result, fingerprinting and dating techniques have been fine-tuned, and tephra beds now under-pin the late Cenozoic chronology for a wide variety of disciplines from volcanology to sequence stratigraphy and archaeology. The key to tephrochronology is the identification and correlation of tephra horizons. In the proximal setting (vent), tephra beds can often be identified by their lithology, stratigraphic position and ferromagnesian mineralogy. Farther from source these features became less diagnostic as units become thinner and mineral depleted, and geochemical fingerprinting must then be employed. Grain-specific techniques are commonly required to assess the compositional homogeneity of the tephra, and to avoid xenolithic and detrital contaminants. Criteria that are valuable for identifying both source volcano and individual eruptive events from grain-specific electron microprobe techniques include: glass and Fe-Ti oxide chemistry, and eruption temperature and oxygen fugacity (estimated from oxide equilibrium pairs). Deposits of the contemporaneously active Taupo, Okataina, Maroa and Mayor Island caldera centres in the TVZ can be distinguished on the basis of such criteria. If a tephra lacks contaminants, trace- and rare earth element (REE) compositions of purified glass separates provide additional criteria. Similar approaches can

  9. Genetic Analyses of Meiotic Recombination in Arabidopsis

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Meiosis is essential for sexual reproduction and recombination is a critical step required for normal meiosis. Understanding the underlying molecular mechanisms that regulate recombination ie important for medical, agricultural and ecological reasons. Readily available molecular and cytological tools make Arabidopsis an excellent system to study meiosis. Here we review recent developments in molecular genetic analyses on meiotic recombination. These Include studies on plant homologs of yeast and animal genes, as well as novel genes that were first identified in plants. The characterizations of these genes have demonstrated essential functions from the initiation of recombination by double-strand breaks to repair of such breaks, from the formation of double-Holliday junctions to possible resolution of these junctions, both of which are critical for crossover formation. The recent advances have ushered a new era in plant meiosis, in which the combination of genetics, genomics, and molecular cytology can uncover important gene functions.

  10. PR Students, Teachers Welcome Corporate Case Study Packages.

    Science.gov (United States)

    Broom, Glen M.; Ferguson-De Thorne, Mary Ann

    1978-01-01

    Reports on an actual public relations problem that was used to introduce students to the practice of corporate public relations. Shows both positive and negative reaction to use of the case study in college classes. (RL)

  11. Modelling a case study in Astronomy with IMS Learning Design

    OpenAIRE

    Burgos, Daniel; Tattersall, Colin

    2009-01-01

    Burgos, D., & Tattersall, C. (2008). Modelling a case study in Astronomy with IMS Learning Design [Electronic Version]. Journal of Interactive Media in Education, 2008 from http://jime.open.ac.uk/2008/19/.

  12. Industrial process heat case studies. [PROSYS/ECONMAT code

    Energy Technology Data Exchange (ETDEWEB)

    Hooker, D.W.; May, E.K.; West, R.E.

    1980-05-01

    Commercially available solar collectors have the potential to provide a large fraction of the energy consumed for industrial process heat (IPH). Detailed case studies of individual industrial plants are required in order to make an accurate assessment of the technical and economic feasibility of applications. This report documents the results of seven such case studies. The objectives of the case study program are to determine the near-term feasibility of solar IPH in selected industries, identify energy conservation measures, identify conditions of IPH systems that affect solar applications, test SERI's IPH analysis software (PROSYS/ECONOMAT), disseminate information to the industrial community, and provide inputs to the SERI research program. The detailed results from the case studies are presented. Although few near-term, economical solar applications were found, the conditions that would enhance the opportunities for solar IPH applications are identified.

  13. HYDROGEOLOGIC CASE STUDIE(PRESENTATION FOR MNA WORKSHOP)

    Science.gov (United States)

    Hydrogeology is the foundation of subsurface site characterization for evaluations of monitored natural attenuation (MNA). Three case studies are presented. Examples of the potentially detrimental effects of drilling additives on ground-water samples from monitoring wells are d...

  14. Whole House Mechanical Ventilation: A South Chicago Case Study

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-09-03

    This case study describes a neighborhood of efficient, healthy, sustainable, affordable homes in South Chicago, IL, that feature structural insulated panels (SIPs), condensing furnaces, sealed combustion water heaters, and efficient lights and appliances.

  15. Using the case-study method in teaching college physics

    OpenAIRE

    Burko, Lior M.

    2016-01-01

    The case-study teaching method has a long history (starting at least with Socrates), and wide current use in business schools, medical schools, law schools, and a variety of other disciplines. However, relatively little use is made of it in the physical sciences, specifically in physics or astronomy. The case-study method should be considered by physics faculty as part of the effort to transition the teaching of college physics from the traditional frontal-lecture format to other formats that...

  16. Transformational change in healthcare: an examination of four case studies.

    Science.gov (United States)

    Charlesworth, Kate; Jamieson, Maggie; Davey, Rachel; Butler, Colin D

    2016-04-01

    Objectives Healthcare leaders around the world are calling for radical, transformational change of our health and care systems. This will be a difficult and complex task. In this article, we examine case studies in which transformational change has been achieved, and seek to learn from these experiences. Methods We used the case study method to investigate examples of transformational change in healthcare. The case studies were identified from preliminary doctoral research into the transition towards future sustainable health and social care systems. Evidence was collected from multiple sources, key features of each case study were displayed in a matrix and thematic analysis was conducted. The results are presented in narrative form. Results Four case studies were selected: two from the US, one from Australia and one from the UK. The notable features are discussed for each case study. There were many common factors: a well communicated vision, innovative redesign, extensive consultation and engagement with staff and patients, performance management, automated information management and high-quality leadership. Conclusions Although there were some notable differences between the case studies, overall the characteristics of success were similar and collectively provide a blueprint for transformational change in healthcare. What is known about the topic? Healthcare leaders around the world are calling for radical redesign of our systems in order to meet the challenges of modern society. What does this paper add? There are some remarkable examples of transformational change in healthcare. The key factors in success are similar across the case studies. What are the implications for practitioners? Collectively, these key factors can guide future attempts at transformational change in healthcare. PMID:26188916

  17. Working multisectorally in nutrition: Principles, practices, and case studies

    OpenAIRE

    Garrett, James; Natalicchio, Marcela

    2011-01-01

    Improving nutrition in developing nations is likely to require a multisectoral approach that involves a variety of ministries and organizations addressing particular aspects of the problem. Despite the promise of such multisectoral efforts, relatively little research has been done on how such efforts can be made effective. Working Multisectorally in Nutrition: Principles, Practices, and Case Studies provides much-needed evidence on this topic. Using case studies from Senegal and Colombia of s...

  18. Case Study Method in Business Education in the USA

    OpenAIRE

    Velushchak Maryna

    2014-01-01

    Business Education is dynamic in nature and needs diverse information to deal with different business problems. To understand the peculiar situations and to manage them effectively, case studies are widely used. Researchers in education have already demonstrated that students' active participation in the educational process increases their learning outcomes. Methods of small group activities, case studies and cooperative student projects give the opportunity to participate actively in the lea...

  19. Case Studies of Heat Integration of Evaporation Systems

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    In this paper, through two case studies, evaporation systems are considered in the context of overall process, and then are optimized to obtain energy-saving effect. The possible evaporation schemes are given when integrated with the background process and how to optimize the evaporator is shown. From the case studies, it can be seen that sometimes incomplete integration and heat pump evaporation are better than complete integration so should be considered as candidate retrofit schemes.

  20. CSSI12 Workshop Proceedings - Case Studies in Service Innovation

    OpenAIRE

    Theodoulidis, Babis

    2012-01-01

    The purpose of Case Studies in Service Innovation is to give the reader insights into how innovation occurs in practice and to stimulate understanding of the underlying theories, models, and tools that contribute to innovation, how it works in practice and how its impact is evaluated. Case Studies in Service Innovation brings together contributions from researchers and practitioners in a celebration of achievements in innovation in practice but also at the same time to look forward by examini...