WorldWideScience

Sample records for arabidopsis case studies

  1. Sustainable funding for biocuration: The Arabidopsis Information Resource (TAIR) as a case study of a subscription-based funding model.

    Science.gov (United States)

    Reiser, Leonore; Berardini, Tanya Z; Li, Donghui; Muller, Robert; Strait, Emily M; Li, Qian; Mezheritsky, Yarik; Vetushko, Andrey; Huala, Eva

    2016-01-01

    Databases and data repositories provide essential functions for the research community by integrating, curating, archiving and otherwise packaging data to facilitate discovery and reuse. Despite their importance, funding for maintenance of these resources is increasingly hard to obtain. Fueled by a desire to find long term, sustainable solutions to database funding, staff from the Arabidopsis Information Resource (TAIR), founded the nonprofit organization, Phoenix Bioinformatics, using TAIR as a test case for user-based funding. Subscription-based funding has been proposed as an alternative to grant funding but its application has been very limited within the nonprofit sector. Our testing of this model indicates that it is a viable option, at least for some databases, and that it is possible to strike a balance that maximizes access while still incentivizing subscriptions. One year after transitioning to subscription support, TAIR is self-sustaining and Phoenix is poised to expand and support additional resources that wish to incorporate user-based funding strategies. Database URL: www.arabidopsis.org.

  2. Sustainable funding for biocuration: The Arabidopsis Information Resource (TAIR) as a case study of a subscription-based funding model.

    Science.gov (United States)

    Reiser, Leonore; Berardini, Tanya Z; Li, Donghui; Muller, Robert; Strait, Emily M; Li, Qian; Mezheritsky, Yarik; Vetushko, Andrey; Huala, Eva

    2016-01-01

    Databases and data repositories provide essential functions for the research community by integrating, curating, archiving and otherwise packaging data to facilitate discovery and reuse. Despite their importance, funding for maintenance of these resources is increasingly hard to obtain. Fueled by a desire to find long term, sustainable solutions to database funding, staff from the Arabidopsis Information Resource (TAIR), founded the nonprofit organization, Phoenix Bioinformatics, using TAIR as a test case for user-based funding. Subscription-based funding has been proposed as an alternative to grant funding but its application has been very limited within the nonprofit sector. Our testing of this model indicates that it is a viable option, at least for some databases, and that it is possible to strike a balance that maximizes access while still incentivizing subscriptions. One year after transitioning to subscription support, TAIR is self-sustaining and Phoenix is poised to expand and support additional resources that wish to incorporate user-based funding strategies. Database URL: www.arabidopsis.org. PMID:26989150

  3. The potential of text mining in data integration and network biology for plant research: a case study on Arabidopsis

    OpenAIRE

    Van Landeghem, Sofie; De Bodt, Stefanie; Drebert, Zuzanna; Inzé, Dirk; Van de Peer, Yves

    2013-01-01

    Despite the availability of various data repositories for plant research, a wealth of information currently remains hidden within the biomolecular literature. Text mining provides the necessary means to retrieve these data through automated processing of texts. However, only recently has advanced text mining methodology been implemented with sufficient computational power to process texts at a large scale. In this study, we assess the potential of large-scale text mining for plant biology res...

  4. Using Arabidopsis to study shoot branching in biomass willow.

    Science.gov (United States)

    Ward, Sally P; Salmon, Jemma; Hanley, Steven J; Karp, Angela; Leyser, Ottoline

    2013-06-01

    The success of the short-rotation coppice system in biomass willow (Salix spp.) relies on the activity of the shoot-producing meristems found on the coppice stool. However, the regulation of the activity of these meristems is poorly understood. In contrast, our knowledge of the mechanisms behind axillary meristem regulation in Arabidopsis (Arabidopsis thaliana) has grown rapidly in the past few years through the exploitation of integrated physiological, genetic, and molecular assays. Here, we demonstrate that these assays can be directly transferred to study the control of bud activation in biomass willow and to assess similarities with the known hormone regulatory system in Arabidopsis. Bud hormone response was found to be qualitatively remarkably similar in Salix spp. and Arabidopsis. These similarities led us to test whether Arabidopsis hormone mutants could be used to assess allelic variation in the cognate Salix spp. hormone genes. Allelic differences in Salix spp. strigolactone genes were observed using this approach. These results demonstrate that both knowledge and assays from Arabidopsis axillary meristem biology can be successfully applied to Salix spp. and can increase our understanding of a fundamental aspect of short-rotation coppice biomass production, allowing more targeted breeding.

  5. Roles of N-terminal fatty acid acylations in membrane compartment partitioning: Arabidopsis h-type thioredoxins as a case study.

    Science.gov (United States)

    Traverso, José A; Micalella, Chiara; Martinez, Aude; Brown, Spencer C; Satiat-Jeunemaître, Béatrice; Meinnel, Thierry; Giglione, Carmela

    2013-03-01

    N-terminal fatty acylations (N-myristoylation [MYR] and S-palmitoylation [PAL]) are crucial modifications affecting 2 to 4% of eukaryotic proteins. The role of these modifications is to target proteins to membranes. Predictive tools have revealed unexpected targets of these acylations in Arabidopsis thaliana and other plants. However, little is known about how N-terminal lipidation governs membrane compartmentalization of proteins in plants. We show here that h-type thioredoxins (h-TRXs) cluster in four evolutionary subgroups displaying strictly conserved N-terminal modifications. It was predicted that one subgroup undergoes only MYR and another undergoes both MYR and PAL. We used plant TRXs as a model protein family to explore the effect of MYR alone or MYR and PAL in the same family of proteins. We used a high-throughput biochemical strategy to assess MYR of specific TRXs. Moreover, various TRX-green fluorescent protein fusions revealed that MYR localized protein to the endomembrane system and that partitioning between this membrane compartment and the cytosol correlated with the catalytic efficiency of the N-myristoyltransferase acting at the N terminus of the TRXs. Generalization of these results was obtained using several randomly selected Arabidopsis proteins displaying a MYR site only. Finally, we demonstrated that a palmitoylatable Cys residue flanking the MYR site is crucial to localize proteins to micropatching zones of the plasma membrane.

  6. Roles of N-Terminal Fatty Acid Acylations in Membrane Compartment Partitioning: Arabidopsis h-Type Thioredoxins as a Case Study[C][W

    Science.gov (United States)

    Traverso, José A.; Micalella, Chiara; Martinez, Aude; Brown, Spencer C.; Satiat-Jeunemaître, Béatrice; Meinnel, Thierry; Giglione, Carmela

    2013-01-01

    N-terminal fatty acylations (N-myristoylation [MYR] and S-palmitoylation [PAL]) are crucial modifications affecting 2 to 4% of eukaryotic proteins. The role of these modifications is to target proteins to membranes. Predictive tools have revealed unexpected targets of these acylations in Arabidopsis thaliana and other plants. However, little is known about how N-terminal lipidation governs membrane compartmentalization of proteins in plants. We show here that h-type thioredoxins (h-TRXs) cluster in four evolutionary subgroups displaying strictly conserved N-terminal modifications. It was predicted that one subgroup undergoes only MYR and another undergoes both MYR and PAL. We used plant TRXs as a model protein family to explore the effect of MYR alone or MYR and PAL in the same family of proteins. We used a high-throughput biochemical strategy to assess MYR of specific TRXs. Moreover, various TRX–green fluorescent protein fusions revealed that MYR localized protein to the endomembrane system and that partitioning between this membrane compartment and the cytosol correlated with the catalytic efficiency of the N-myristoyltransferase acting at the N terminus of the TRXs. Generalization of these results was obtained using several randomly selected Arabidopsis proteins displaying a MYR site only. Finally, we demonstrated that a palmitoylatable Cys residue flanking the MYR site is crucial to localize proteins to micropatching zones of the plasma membrane. PMID:23543785

  7. Reproductive Toxicity and Life History Study of Silver Nanoparticle Effect, Uptake and Transport in Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Jane Geisler-Lee

    2014-04-01

    Full Text Available Concerns about nanotechnology have prompted studies on how the release of these engineered nanoparticles impact our environment. Herein, the impact of 20 nm silver nanoparticles (AgNPs on the life history traits of Arabidopsis thaliana was studied in both above- and below-ground parts, at macroscopic and microscopic scales. Both gross phenotypes (in contrast to microscopic phenotypes and routes of transport and accumulation were investigated from roots to shoots. Wild type Arabidopsis growing in soil, regularly irrigated with 75 μg/L of AgNPs, did not show any obvious morphological change. However, their vegetative development was prolonged by two to three days and their reproductive growth shortened by three to four days. In addition, the germination rates of offspring decreased drastically over three generations. These findings confirmed that AgNPs induce abiotic stress and cause reproductive toxicity in Arabidopsis. To trace transport of AgNPs, this study also included an Arabidopsis reporter line genetically transformed with a green fluorescent protein and grown in an optical transparent medium with 75 μg/L AgNPs. AgNPs followed three routes: (1 At seven days after planting (DAP at S1.0 (stages defined by Boyes et al. 2001 [41], AgNPs attached to the surface of primary roots and then entered their root tips; (2 At 14 DAP at S1.04, as primary roots grew longer, AgNPs gradually moved into roots and entered new lateral root primordia and root hairs; (3 At 17 DAP at S1.06 when the Arabidopsis root system had developed multiple lateral roots, AgNPs were present in vascular tissue and throughout the whole plant from root to shoot. In some cases, if cotyledons of the Arabidopsis seedlings were immersed in melted transparent medium, then AgNPs were taken up by and accumulated in stomatal guard cells. These findings in Arabidopsis are the first to document specific routes and rates of AgNP uptake in vivo and in situ.

  8. Case Studies

    International Nuclear Information System (INIS)

    Proven options available to Sri Lanka for large scale electricity generation in the future are coal-fired thermal, oil-fired thermal and Nuclear. Four case studies for groups participated are indicated. Case study for group 1 is comparison of the three options by taking into consideration the capital and recurrent expenditure involved. Environmental effects of the three options are also given. Case study for group 2 is economic comparison of three renewable energy based power generation system. Case study for group 3 is based on energy conservation, efficiency, improvement and demand management. Assuming that a continuous saving of 20 MW of demand from 1996 onwards is effective two projects are suggested to achieve this result. Case study for group 4 is a feasibility study for hydro power development of the Kukule Ganga (river) in Sri Lanka. Participants are required to evaluate one of the three optional development concepts which are technically feasible

  9. A proteomics study of auxin effects in Arabidopsis thaliana

    Institute of Scientific and Technical Information of China (English)

    Meiqing Xing; Hongwei Xue

    2012-01-01

    Many phytohormones regulate plant growth and development through modulating protein degradation.In this study,a proteome study based on multidimensional non-gel shotgun approach was performed to analyze the auxin-induced protein degradation via ubiquitinproteasome pathway of Arabidopsis thaliana,with the emphasis to study the overall protein changes after auxin treatment (1 nM or 1 μM indole-3-acetic acid for 6,12,or 24 h).More than a thousand proteins were detected by using label-free shotgun method,and 386 increased proteins and 370 decreased ones were identified after indole-3-acetic acid treatment.By using the auxin receptor-deficient mutant,tir1-1,as control,comparative analysis revealed that 69 and 79 proteins were significantly decreased and increased,respectively.Detailed analysis showed that among the altered proteins,some were previously reported to be associated with auxin regulation and others are potentially involved in mediating the auxin effects on specific cellular and physiological processes by regulating photosynthesis,chloroplast development,cytoskeleton,and intracellular signaling.Our results demonstrated that label-free shotgun proteomics is a powerful tool for large-scale protein identification and the analysis of the proteomic profiling of auxin-regulated biological processes will provide informative clues of underlying mechanisms of auxin effects.These results will help to expand the understanding of how auxin regulates plant growth and development via protein degradation.

  10. Molecular screening tools to study Arabidopsis transcription factors

    Directory of Open Access Journals (Sweden)

    Nora eWehner

    2011-11-01

    Full Text Available In the model plant Arabidopsis thaliana, more than 2000 genes are estimated to encode transcription factors (TFs, which clearly emphasizes the importance of transcriptional control. Although genomic approaches have generated large TF Open Reading Frame (ORF collections, only a limited number of these genes is functionally characterized, yet. This review evaluates strategies and methods to identify TF functions. In particular, we focus on two recently developed TF screening platforms, which make use of publi-cally available GATEWAY® compatible ORF collections. (1 The Arabidopsis thaliana TF ORF over-Expression (AtTORF-Ex library provides pooled collections of transgenic lines over-expressing HA-tagged TF genes, which are suited for screening approaches to define TF functions in stress defense and development. (2 A high-throughput microtiter plate based Protoplast Trans Activation (PTA system has been established to screen for TFs which are regulating a given promoter:Luciferase construct in planta.

  11. Case Study: Writing a Journal Case Study

    Science.gov (United States)

    Prud'homme-Genereux, Annie

    2016-01-01

    This column provides original articles on innovations in case study teaching, assessment of the method, as well as case studies with teaching notes. This month's issue describes incorporating a journal article into the classroom by first converting it into a case study.

  12. Study of natural variation for Zn deficiency tolerance in Arabidopsis thaliana

    NARCIS (Netherlands)

    Campos, A.C.A.L.

    2015-01-01

    English summary Zinc is an important structural component and co-factor of proteins in all living organisms. The model plant species for genetic and molecular studies, Arabidopsis thaliana, expresses more than 2,000 proteins with one or more Zn binding domains. Low Zn availability i

  13. Project management case studies

    CERN Document Server

    Kerzner, Harold R

    2013-01-01

    A new edition of the most popular book of project management case studies, expanded to include more than 100 cases plus a ""super case"" on the Iridium Project Case studies are an important part of project management education and training. This Fourth Edition of Harold Kerzner''s Project Management Case Studies features a number of new cases covering value measurement in project management. Also included is the well-received ""super case,"" which covers all aspects of project management and may be used as a capstone for a course. This new edition:Contains 100-plus case studies drawn from re

  14. Arabidopsis seedling flood-inoculation technique: a rapid and reliable assay for studying plant-bacterial interactions

    Directory of Open Access Journals (Sweden)

    Uppalapati Srinivasa R

    2011-10-01

    Full Text Available Abstract Background The Arabidopsis thaliana-Pseudomonas syringae model pathosystem is one of the most widely used systems to understand the mechanisms of microbial pathogenesis and plant innate immunity. Several inoculation methods have been used to study plant-pathogen interactions in this model system. However, none of the methods reported to date are similar to those occurring in nature and amicable to large-scale mutant screens. Results In this study, we developed a rapid and reliable seedling flood-inoculation method based on young Arabidopsis seedlings grown on MS medium. This method has several advantages over conventional soil-grown plant inoculation assays, including a shorter growth and incubation period, ease of inoculation and handling, uniform infection and disease development, requires less growth chamber space and is suitable for high-throughput screens. In this study we demonstrated the efficacy of the Arabidopsis seedling assay to study 1 the virulence factors of P. syringae pv. tomato DC3000, including type III protein secretion system (TTSS and phytotoxin coronatine (COR; 2 the effector-triggered immunity; and 3 Arabidopsis mutants affected in salicylic acid (SA- and pathogen-associated molecular pattern (PAMPs-mediated pathways. Furthermore, we applied this technique to study nonhost resistance (NHR responses in Arabidopsis using nonhost pathogens, such as P. syringae pv. tabaci, pv. glycinea and pv. tomato T1, and confirmed the functional role of FLAGELLIN-SENSING 2 (FLS2 in NHR. Conclusions The Arabidopsis seedling flood-inoculation assay provides a rapid, efficient and economical method for studying Arabidopsis-Pseudomonas interactions with minimal growth chamber space and time. This assay could also provide an excellent system for investigating the virulence mechanisms of P. syringae. Using this method, we demonstrated that FLS2 plays a critical role in conferring NHR against nonhost pathovars of P. syringae, but not to

  15. A comparative study of salt tolerance parameters in 11 wild relatives of Arabidopsis thaliana

    KAUST Repository

    Orsini, Francesco

    2010-07-01

    Salinity is an abiotic stress that limits both yield and the expansion of agricultural crops to new areas. In the last 20 years our basic understanding of the mechanisms underlying plant tolerance and adaptation to saline environments has greatly improved owing to active development of advanced tools in molecular, genomics, and bioinformatics analyses. However, the full potential of investigative power has not been fully exploited, because the use of halophytes as model systems in plant salt tolerance research is largely neglected. The recent introduction of halophytic Arabidopsis-Relative Model Species (ARMS) has begun to compare and relate several unique genetic resources to the well-developed Arabidopsis model. In a search for candidates to begin to understand, through genetic analyses, the biological bases of salt tolerance, 11 wild relatives of Arabidopsis thaliana were compared: Barbarea verna, Capsella bursa-pastoris, Hirschfeldia incana, Lepidium densiflorum, Malcolmia triloba, Lepidium virginicum, Descurainia pinnata, Sisymbrium officinale, Thellungiella parvula, Thellungiella salsuginea (previously T. halophila), and Thlaspi arvense. Among these species, highly salt-tolerant (L. densiflorum and L. virginicum) and moderately salt-tolerant (M. triloba and H. incana) species were identified. Only T. parvula revealed a true halophytic habitus, comparable to the better studied Thellungiella salsuginea. Major differences in growth, water transport properties, and ion accumulation are observed and discussed to describe the distinctive traits and physiological responses that can now be studied genetically in salt stress research. 2010 The Author.

  16. Genetic and histological studies on the delayed systemic movement of Tobacco Mosaic Virus in Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Matus José

    2008-09-01

    Full Text Available Abstract Background Viral infections and their spread throughout a plant require numerous interactions between the host and the virus. While new functions of viral proteins involved in these processes have been revealed, current knowledge of host factors involved in the spread of a viral infection is still insufficient. In Arabidopsis thaliana, different ecotypes present varying susceptibilities to Tobacco mosaic virus strain U1 (TMV-U1. The rate of TMV-U1 systemic movement is delayed in ecotype Col-0 when compared with other 13 ecotypes. We followed viral movement through vascular tissue in Col-0 plants by electronic microscopy studies. In addition, the delay in systemic movement of TMV-U1 was genetically studied. Results TMV-U1 reaches apical leaves only after 18 days post rosette inoculation (dpi in Col-0, whereas it is detected at 9 dpi in the Uk-4 ecotype. Genetic crosses between Col-0 and Uk-4 ecotypes, followed by analysis of viral movement in F1 and F2 populations, revealed that this delayed movement correlates with a recessive, monogenic and nuclear locus. The use of selected polymorphic markers showed that this locus, denoted DSTM1 (Delayed Systemic Tobamovirus Movement 1, is positioned on the large arm of chromosome II. Electron microscopy studies following the virion's route in stems of Col-0 infected plants showed the presence of curved structures, instead of the typical rigid rods of TMV-U1. This was not observed in the case of TMV-U1 infection in Uk-4, where the observed virions have the typical rigid rod morphology. Conclusion The presence of defectively assembled virions observed by electron microscopy in vascular tissue of Col-0 infected plants correlates with a recessive delayed systemic movement trait of TMV-U1 in this ecotype.

  17. A Microarray Based Genomic Hybridization Method for Identification of New Genes in Plants: Case Analyses of Arabidopsis and Oryza

    Institute of Scientific and Technical Information of China (English)

    Chuanzhu Fan; Maria D. Vibranovski; Ying Chen; Manyuan Long

    2007-01-01

    To systematically estimate the gene duplication events in closely related species, we have to use comparative genomic approaches, either through genomic sequence comparison or comparative genomic hybridization (CGH). Given the scarcity of complete genomic sequences of plant species, in the present study we adopted an array based CGH to investigate gene duplications in the genus Arabidopsis. Fragment genomic DNA from four species, namely Arabidopsis thaliana, A. lyrata subsp. lyrata, A. lyrata subsp. petraea, and A. halleri, was hybridized to Affymetrix (Santa Clara, CA, USA) tiling arrays that are designed from the genomic sequences of A. thaliana. Pairwise comparisons of signal intensity were made to infer the potential duplicated candidates along each phylo-genetic branch. Ninety-four potential candidates of gene duplication along the genus were identified. Among them, the majority (69 of 94) were A. thaliana lineage specific. This result indicates that the array based CGH approach may be used to identify candidates of duplication in other plant genera containing closely related species, such as Oryza, particularly for the AA genome species. We compared the degree of gene duplication through retrotransposon between O. sativa and A. thaliana and found a strikingly higher number of chimera retroposed genes in rice. The higher rate of gene duplication through retroposition and other mechanisms may indicate that the grass species is able to adapt to more diverse environments.

  18. Objectivist case study research

    DEFF Research Database (Denmark)

    Ridder, Hanne Mette Ochsner; Fachner, Jörg

    2016-01-01

    be achieved through the use of objectivist case study research. The strength of the case study design is that it allows for uncovering or suggesting causal relationships in real-life settings through an intensive and rich collection of data. According to Hilliard (1993), the opposite applies for extensive......In order to comprehend the impact of music therapy or music therapy processes, a researcher might look for an approach where the topic under investigation can be understood within a broader context. This calls for a rich inclusion of data and consequently a limited number of participants and may...... designs, in which a small amount of data is gathered on a large number of subjects. With the richness of data, the intensive design is ―the primary pragmatic reason for engaging in single-case or small N research‖ (p. 374) and for working from an idiographic rather than a nomothetic perspective....

  19. Case Studies in Biology.

    Science.gov (United States)

    Zeakes, Samuel J.

    1989-01-01

    A case study writing exercise used in a course on parasitology was found to be a powerful learning experience for students because it involved discipline-based technical writing and terminology, brought the students in as evaluators, applied current learning, caused interaction among all students, and simulated real professional activities. (MSE)

  20. : Case studies: France

    OpenAIRE

    Bonerandi, Emmanuelle; Santamaria, Frédéric

    2005-01-01

    Case studies on territorial governance : urban region of Lyon (France) and the "Pays" policy (France) in the framework of the ESPON 2.3.2 project Études de cas sur la gouvernance territoriale : région urbaine de Lyon et politique des pays

  1. Rotordynamic Stability Case Studies

    OpenAIRE

    Choudhury Pranabesh

    2004-01-01

    In this article case studies are presented involving rotordynamic instability of modern high-speed turbomachinery relating the field data to analytical methods. The studies include oil seal related field problems, instability caused by aerodynamic cross-coupling in high-pressure, high-speed compressors, and hydrodynamic bearing instability resulting in subsynchronous vibration of a high-speed turbocharger. It has been shown that the analytical tools not only help in problem diagnostics, bu...

  2. PageRank-based identification of signaling crosstalk from transcriptomics data: the case of Arabidopsis thaliana.

    Science.gov (United States)

    Omranian, Nooshin; Mueller-Roeber, Bernd; Nikoloski, Zoran

    2012-04-01

    The levels of cellular organization, from gene transcription to translation to protein-protein interaction and metabolism, operate via tightly regulated mutual interactions, facilitating organismal adaptability and various stress responses. Characterizing the mutual interactions between genes, transcription factors, and proteins involved in signaling, termed crosstalk, is therefore crucial for understanding and controlling cells' functionality. We aim at using high-throughput transcriptomics data to discover previously unknown links between signaling networks. We propose and analyze a novel method for crosstalk identification which relies on transcriptomics data and overcomes the lack of complete information for signaling pathways in Arabidopsis thaliana. Our method first employs a network-based transformation of the results from the statistical analysis of differential gene expression in given groups of experiments under different signal-inducing conditions. The stationary distribution of a random walk (similar to the PageRank algorithm) on the constructed network is then used to determine the putative transcripts interrelating different signaling pathways. With the help of the proposed method, we analyze a transcriptomics data set including experiments from four different stresses/signals: nitrate, sulfur, iron, and hormones. We identified promising gene candidates, downstream of the transcription factors (TFs), associated to signaling crosstalk, which were validated through literature mining. In addition, we conduct a comparative analysis with the only other available method in this field which used a biclustering-based approach. Surprisingly, the biclustering-based approach fails to robustly identify any candidate genes involved in the crosstalk of the analyzed signals. We demonstrate that our proposed method is more robust in identifying gene candidates involved downstream of the signaling crosstalk for species for which large transcriptomics data sets

  3. PageRank-based identification of signaling crosstalk from transcriptomics data: the case of Arabidopsis thaliana.

    Science.gov (United States)

    Omranian, Nooshin; Mueller-Roeber, Bernd; Nikoloski, Zoran

    2012-04-01

    The levels of cellular organization, from gene transcription to translation to protein-protein interaction and metabolism, operate via tightly regulated mutual interactions, facilitating organismal adaptability and various stress responses. Characterizing the mutual interactions between genes, transcription factors, and proteins involved in signaling, termed crosstalk, is therefore crucial for understanding and controlling cells' functionality. We aim at using high-throughput transcriptomics data to discover previously unknown links between signaling networks. We propose and analyze a novel method for crosstalk identification which relies on transcriptomics data and overcomes the lack of complete information for signaling pathways in Arabidopsis thaliana. Our method first employs a network-based transformation of the results from the statistical analysis of differential gene expression in given groups of experiments under different signal-inducing conditions. The stationary distribution of a random walk (similar to the PageRank algorithm) on the constructed network is then used to determine the putative transcripts interrelating different signaling pathways. With the help of the proposed method, we analyze a transcriptomics data set including experiments from four different stresses/signals: nitrate, sulfur, iron, and hormones. We identified promising gene candidates, downstream of the transcription factors (TFs), associated to signaling crosstalk, which were validated through literature mining. In addition, we conduct a comparative analysis with the only other available method in this field which used a biclustering-based approach. Surprisingly, the biclustering-based approach fails to robustly identify any candidate genes involved in the crosstalk of the analyzed signals. We demonstrate that our proposed method is more robust in identifying gene candidates involved downstream of the signaling crosstalk for species for which large transcriptomics data sets

  4. Corporate Governance. Case Studies

    OpenAIRE

    Manuel, Eduardo

    2007-01-01

    This paper pretends to do a theoretical approach of Corporate Governance, having as support some case studies about companies like Coca-Cola, Nokia, Microsoft, and Amazon.com. The methodology adopted for this work is based in information from these companies available in their websites and annual reports. I concluded that both companies show the corporate governance components according to their core business and their environmental business.

  5. Case study - Czechoslovakia

    International Nuclear Information System (INIS)

    In the lecture Case Study - Czechoslovakia with the sub-title 'Unified System of Personnel Preparation for Nuclear Programme in Czechoslovakia' the actual status and the current experience of NPP personnel training and preparation in Czechoslovakia are introduced. The above mentioned training system is presented and demonstrated by the story of a proxy person who is going to become shift engineer in a nuclear power plant in Czechoslovakia. (orig./HP)

  6. Case Studies - Cervical Cancer

    Centers for Disease Control (CDC) Podcasts

    2010-10-15

    Dr. Alan Waxman, a professor of obstetrics and gynecology at the University of New Mexico and chair of the American College of Obstetricians and Gynecologists (ACOG) committee for the underserved, talks about several case studies for cervical cancer screening and management.  Created: 10/15/2010 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Division of Cancer Prevention and Control (DCPC).   Date Released: 6/9/2010.

  7. Comparative molecular modeling study of Arabidopsis NADPH-dependent thioredoxin reductase and its hybrid protein.

    Directory of Open Access Journals (Sweden)

    Yuno Lee

    Full Text Available 2-Cys peroxiredoxins (Prxs play important roles in the protection of chloroplast proteins from oxidative damage. Arabidopsis NADPH-dependent thioredoxin reductase isotype C (AtNTRC was identified as efficient electron donor for chloroplastic 2-Cys Prx-A. There are three isotypes (A, B, and C of thioredoxin reductase (TrxR in Arabidopsis. AtNTRA contains only TrxR domain, but AtNTRC consists of N-terminal TrxR and C-terminal thioredoxin (Trx domains. AtNTRC has various oligomer structures, and Trx domain is important for chaperone activity. Our previous experimental study has reported that the hybrid protein (AtNTRA-(Trx-D, which was a fusion of AtNTRA and Trx domain from AtNTRC, has formed variety of structures and shown strong chaperone activity. But, electron transfer mechanism was not detected at all. To find out the reason of this problem with structural basis, we performed two different molecular dynamics (MD simulations on AtNTRC and AtNTRA-(Trx-D proteins with same cofactors such as NADPH and flavin adenine dinucleotide (FAD for 50 ns. Structural difference has found from superimposition of two structures that were taken relatively close to average structure. The main reason that AtNTRA-(Trx-D cannot transfer the electron from TrxR domain to Trx domain is due to the difference of key catalytic residues in active site. The long distance between TrxR C153 and disulfide bond of Trx C387-C390 has been observed in AtNTRA-(Trx-D because of following reasons: i unstable and unfavorable interaction of the linker region, ii shifted Trx domain, and iii different or weak interface interaction of Trx domains. This study is one of the good examples for understanding the relationship between structure formation and reaction activity in hybrid protein. In addition, this study would be helpful for further study on the mechanism of electron transfer reaction in NADPH-dependent thioredoxin reductase proteins.

  8. NOx trade. Case studies

    International Nuclear Information System (INIS)

    Some of the questions with respect to the trade of nitrogen oxides that businesses in the Netherlands have to deal with are dealt with: should a business buy or sell rights for NOx emission; which measures must be taken to reduce NOx emission; how much must be invested; and how to deal with uncertainties with regard to prices. Simulations were carried out with the MOSES model to find the answers to those questions. Results of some case studies are presented, focusing on the chemical sector in the Netherlands. Finally, the financial (dis)advantages of NOx trade and the related uncertainties for a single enterprise are discussed

  9. Multigenerational versus single generation studies to estimate herbicide resistance fitness cost in Arabidopsis thaliana.

    Science.gov (United States)

    Roux, Fabrice; Camilleri, Christine; Bérard, Aurélie; Reboud, Xavier

    2005-10-01

    The evolution of resistance in response to pesticide selection is expected to be delayed if fitness costs are associated with resistance genes. The estimate of fitness costs usually involves comparing major growth traits of resistant versus susceptible individuals in the absence of pesticide. Ideally, a measure of changes in resistance allele frequency over several generations would allow the best estimate of the overall fitness cost of a resistance gene. In greenhouse conditions, we monitored the dynamics of the evolution of the frequencies of six herbicide-resistant mutations (acetolactate synthase, cellulose synthase, and auxin-induced target genes) in the model species Arabidopsis thaliana in a multigenerational study covering five to seven nonoverlapping generations. The microevolutionary dynamics in experimental populations indicated a mean fitness cost of 38%, 73%, and 94% for the ixr1-2, axr1-3, and axr2-1 resistances, respectively; no fitness cost for the csr1-1, and ixr2-1 resistances; and a transient advantage for the aux1-7 resistance. The result for the csr1-1 resistance contrasts with a cost of 37% based on total seed number in a previous study, demonstrating that single generation studies could have limitation for detecting cost. A positive frequency dependence for the fitness cost was also detected for the ixr1-2 resistance. The results are discussed in relation to the maintenance of polymorphism at resistance loci. PMID:16405169

  10. Vertebral Angiosarcoma. Case Study.

    Science.gov (United States)

    Guzik, Grzegorz

    2015-01-01

    Bone angiosarcomas, especially vertebral angiosarcomas, are very rare. There are no studies based on large clinical samples in the literature, and only a few single case reports can be found. The symptoms of the disease are not specific. It is usually detected incidentally or at a late stage when pathological vertebral fractures or neurological complications occur. Diagnostic imaging and history help to recognize the tumour behind the symptoms, but do not allow accurate clinical diagnosis. The basis for a diagnosis is the histopathological examination supported by immunohistochemistry (IHC) assays. The case of a 26-year-old woman with an angiosarcoma involving the eighth thoracic vertebra we report reflects diagnostic problems adversely affecting the efficacy and accuracy of treatment offered to patients. The patient underwent three surgeries of the spine, including two biopsies. A needle biopsy did not provide sufficient information for the diagnosis. An open excisional biopsy, which at the same time temporarily reduced neurological deficits in the patient, was the only chance to obtain an accurate diagnosis. The third surgery was posterior decompression of the spinal cord due to the rapidly escalating paraparesis. It was not until 8 weeks later that the final diagnosis was established. At that time, the patient could not be qualified for any supplementary treatment. The patient died in hospital 6 months after the onset of disease. PMID:26468177

  11. Polyol specificity of recombinant Arabidopsis thaliana sorbitol dehydrogenase studied by enzyme kinetics and in silico modeling

    Directory of Open Access Journals (Sweden)

    María Francisca eAguayo

    2015-02-01

    Full Text Available Polyols are enzymatically-produced plant compounds which can act as compatible solutes during periods of abiotic stress. NAD+-dependent SORBITOL DEHYDROGENASE (SDH, E.C. 1.1.1.14 from Arabidopsis thaliana L. (AtSDH is capable of oxidizing several polyols including sorbitol, ribitol and xylitol. In the present study, enzymatic assays using recombinant AtSDH demonstrated a higher specificity constant for xylitol compared to sorbitol and ribitol, all of which are C2 (S and C4 (R polyols. Enzyme activity was reduced by preincubation with ethylenediaminetetraacetic acid (EDTA, indicating a requirement for zinc ions. In humans, it has been proposed that sorbitol becomes part of a pentahedric coordination sphere of the catalytic zinc during the reaction mechanism. In order to determine the validity of this pentahedric coordination model in a plant SDH, homology modeling and Molecular Dynamics simulations of AtSDH ternary complexes with the three polyols were performed using crystal structures of human and Bemisia argentifolii (Genn. (Hemiptera: Aleyrodidae SDHs as scaffolds. The results indicate that the differences in interaction with structural water molecules correlate very well with the observed enzymatic parameters, validate the proposed pentahedric coordination of the catalytic zinc ion in a plant SDH, and provide an explanation for why AtSDH shows a preference for polyols with a chirality of C2 (S and C4 (R.

  12. Examples and Case Studies

    NARCIS (Netherlands)

    Asbach, C.; Aguerre, O.; Bressot, C.; Brouwer, D.H.; Gommel, U.; Gorbunov, B.; Bihan, O. le; Jensen, K.A.; Kaminski, H.; Keller, M.; Koponen, I.K.; Kuhlbusch, T.A.J.; Lecloux, A.; Morgeneyer, M.; Muir, R.; Shandilya, N.; Stahlmecke, B.; Todea, A.M.

    2014-01-01

    Release of nanomaterials may occur during any stage of the life-cycle and can eventually lead to exposure to humans, the environment or products. Due to the large number of combinations of release processes and nanomaterials, release scenarios can currently only be tested on a case-by-case basis. Th

  13. Termination: A Case Study.

    Science.gov (United States)

    Friedberg, Ahron L

    2015-12-01

    In this article I posit and examine certain criteria and qualities for ending an analysis. The case study describes the end phase of a four-year psychoanalysis in which the patient's decision to move to another area forced the end of his analysis. We continued to explore and work through his core neurotic conflicts that included issues of competitive rivalry, dominance and submission, control, and anxiety about birth and death. A shift in the transference from me as a negative father to me as a supportive but competitive older brother was also examined in the context of ending treatment as well as other aspects of the transference. In addition, we analyzed the meaning of his ending treatment based on an extra-analytic circumstance. In discussing this phase of treatment, the definition and history of the term "termination" and its connotations are reviewed. Various criteria for completing an analysis are examined, and technical observations about this phase of treatment are investigated. It was found that while a significant shift in the transference occurred in this phase of the patient's analysis, conflicts related to the transference were not "resolved" in the classical sense. Terminating treatment was considered as a practical matter in which the patient's autonomy and sense of choice were respected and analyzed. PMID:26583444

  14. Exploring valid reference genes for quantitative real - time rt - pce studies of hydrogenperoxide signaling in arabidopsis

    International Nuclear Information System (INIS)

    Hydrogen peroxide (H/sub 2/O/sub 2/ ) acts as a signaling molecule modulating the expression of various genes in plants. However, the reference gene(s) used for gene expression analysis of H/sub 2/O/sub 2/ signaling is still arbitrary. A reliable result obtained by quantitative real-time RT-PCR (RT-qPCR) highly depends on accurate transcript normalization using stably expressed reference genes, whereas the inaccurate normalization could easily lead to the false conclusions. In this report, by using geNorm and NormFinder algorithms, 12 candidate reference genes were evaluated and compared in root and shoot tissues of Arabidopsis upon different doses of H/sub 2/O/sub 2/. The results revealed that, in our experimental conditions, three novel reference genes (TIP41-like, UKN, and UBC21) were identified and validated as suitable reference genes for RT-qPCR normalization in both root and shoot tissues under oxidative stress. This conclusion was further confirmed by publicly available microarray data of methyl viologen and drought stress. In comparison with a single reference gene (EF-1a), the expression pattern of ZAT12 modulated by H/sub 2/O/sub 2/, when using TIP41-like, UKN, and UBC21 as multiple reference gene(s), was similar with the previous reports by using northern blotting. Thus, we proposed that these three reference genes might be good candidates for other researchers to include in their reference gene validation in gene expression studies under H/sub 2/O/sub 2/ related oxidative stress. (author)

  15. Teaching Pharmacology by Case Study.

    Science.gov (United States)

    Jordan, Sue

    1997-01-01

    Using pharmacology case studies with nursing students encourages theory-practice links and infuses real-life content. Cases provide rich qualitative data for evaluating curriculum. However, they are not a substitute for evidence-based practice. (SK)

  16. Suppressor Screens in Arabidopsis.

    Science.gov (United States)

    Li, Xin; Zhang, Yuelin

    2016-01-01

    Genetic screens have proven to be a useful tool in the dissection of biological processes in plants. Specifically, suppressor screens have been widely used to study signal transduction pathways. Here we provide a detailed protocol for ethyl methanesulfonate (EMS) mutagenesis used in our suppressor screens in Arabidopsis and discuss the basic principles behind suppressor screen design and downstream analyses. PMID:26577776

  17. Intercultural Communicative Case Study

    Institute of Scientific and Technical Information of China (English)

    吴冬梅

    2009-01-01

    The essay is mainly about the author's comprehension of cultural differences and intercultural communication after reading the book Communication Between Cultures.In addition,the author also analyses three cases with the theories and approaches mentioned in Communication Between Cultures.

  18. Characterization and pilot functional study of a rootspecific MYB transcription factor of Arabidopsis

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    An MYB transcription factor (AtMYB305) ofArabidopsis was structurally characterized. The biochemical activity of the protein was tested and its in vivo function was preliminarily analyzed. AtMYB305 contains two imperfect repeats (R2, R3) in its DNA binding domain. Gel mobility shift assay demonstrated that GST-AtMYB305 fusion protein bound specifically to the DNA fragment that included a consensus MYB recognition sequence (TAACTG). Overexpression of AtMYB305 in the fission yeast caused the formation of elongated cells with one condensed nucleus.Semi-quantitative RT-PCR analysis revealed that AtMYB305was expressed specifically in the roots of Arabidopsis.

  19. Case Study - "Marketing Christmas"

    Institute of Scientific and Technical Information of China (English)

    何青青

    2011-01-01

    @@ The following is based on a real case but the name of the company has been changed and the source will only be revealed after the submission deadline.It is June in Eastern China and temperatures are over 30 degrees Celsius.In Huang Yi-Ju's wholesale showroom, based in Yiwu, model Father Christmases line the shelves, fill the floors and scale the walls.

  20. Global and targeted proteomics in Arabidopsis thaliana: A study of secondary metabolism and phytohormone signaling

    OpenAIRE

    Slade Jr, William O

    2013-01-01

    Proteomics is defined as a tool to explore how proteins control and regulate important molecular and physiological processes. Further, peptide-centric approaches, or bottom-up methods, provide more comprehensive coverage of a proteome compared to whole-protein approaches. This body of work assesses the technical feasibility of several bottom-up proteomics technologies applied to Arabidopsis thaliana, including gel-based methods, those that require peptide derivitization, and those that do n...

  1. A Preliminary Study on a Specifically Expressed Arabidopsis Promotor in Vascular Bundle

    Institute of Scientific and Technical Information of China (English)

    谷运红; 谢传晓; 吴丽芳; 余增亮; 秦广雍; 霍裕平

    2003-01-01

    From a population of about 3500 single plants in Arabidopsis promoter trapping bank, one plant whose GUS-gene had been specifically expressed in vascular bundle, was screened by the method of gus tissue staining. The T-DNA flanking sequence was amplified using TAILPCR. This band will be purified and connected to TA cloning vector. After sequencing and searching in the genebank, its function will be demonatrated through transformation.

  2. Optimization of transient expression procedures in Catharanthus roseus and Arabidopsis thaliana for subcellular localization studies

    OpenAIRE

    Ribeiro, Diana Margarida da Costa

    2010-01-01

    Dissertação de mestrado em Biotecnologia e Bio-Empreendedorismo em Plantas Aromáticas e Medicinais Nowadays, the availability of much gene sequence information demands the development of tools for their fast characterization at the protein level, where function actually resides. Here, the interest in the characterization of certain of the known Arabidopsis class III peroxidase (Prx) genes, as well as the interest in the characterization of candidate genes implicated in the meta...

  3. Case Study: Case Studies and the Flipped Classroom

    Science.gov (United States)

    Herreid, Clyde Freeman; Schiller, Nancy A.

    2013-01-01

    This column provides original articles on innovations in case study teaching, assessment of the method, as well as case studies with teaching notes. This month's issue discusses the positive and negative aspects of the "flipped classroom." In the flipped classroom model, what is normally done in class and what is normally done as…

  4. Building theories from case study research: the progressive case study

    NARCIS (Netherlands)

    Steenhuis, Harm-Jan; Bruijn, de Erik J.

    2006-01-01

    Meredith (1998) argues for more case and field research studies in the field of operations management. Based on a literature review, we discuss several existing approaches to case studies and their characteristics. These approaches include; the Grounded Theory approach which proposes no prior litera

  5. Theory Testing Using Case Studies

    DEFF Research Database (Denmark)

    Møller, Ann-Kristina Løkke; Dissing Sørensen, Pernille

    2014-01-01

    testing using case studies, including the associated research goal, analysis, and generalisability. We argue that research designs for theory testing using case studies differ from theorybuilding case study research designs because different research projects serve different purposes and follow different......The appropriateness of case studies as a tool for theory testing is still a controversial issue, and discussions about the weaknesses of such research designs have previously taken precedence over those about its strengths. The purpose of the paper is to examine and revive the approach of theory...... research paths....

  6. Theory testing using case studies

    DEFF Research Database (Denmark)

    Dissing Sørensen, Pernille; Løkke Nielsen, Ann-Kristina

    Case studies may have different research goals. One such goal is the testing of small-scale and middle-range theories. Theory testing refers to the critical examination, observation, and evaluation of the 'why' and 'how' of a specified phenomenon in a particular setting. In this paper, we focus...... on the strengths of theory-testing case studies. We specify research paths associated with theory testing in case studies and present a coherent argument for the logic of theoretical development and refinement using case studies. We emphasize different uses of rival explanations and their implications for research...... design. Finally, we discuss the epistemological logic, i.e., the value to larger research programmes, of such studies and, following Lakatos, conclude that the value of theory-testing case studies lies beyond naïve falsification and in their contribution to developing research programmes in a progressive...

  7. Three Community College Case Studies

    Science.gov (United States)

    Wojtysiak, Joseph; Sutton, William J., II; Wright, Tommy; Brantley, Linda

    2011-01-01

    This article presents three case studies that focus on specific projects that are underway or have been completed. In the first case study, Joseph Wojtysiak and William J. Sutton, II discuss the Green Center of Central Pennsylvania, which is designed to serve as the state's preeminent source for education, training and public information about…

  8. Information flow during gene activation by signaling molecules: ethylene transduction in Arabidopsis cells as a study system

    Directory of Open Access Journals (Sweden)

    Díaz José

    2009-05-01

    Full Text Available Abstract Background We study root cells from the model plant Arabidopsis thaliana and the communication channel conformed by the ethylene signal transduction pathway. A basic equation taken from our previous work relates the probability of expression of the gene ERF1 to the concentration of ethylene. Results The above equation is used to compute the Shannon entropy (H or degree of uncertainty that the genetic machinery has during the decoding of the message encoded by the ethylene specific receptors embedded in the endoplasmic reticulum membrane and transmitted into the nucleus by the ethylene signaling pathway. We show that the amount of information associated with the expression of the master gene ERF1 (Ethylene Response Factor 1 can be computed. Then we examine the system response to sinusoidal input signals with varying frequencies to determine if the cell can distinguish between different regimes of information flow from the environment. Our results demonstrate that the amount of information managed by the root cell can be correlated with the frequency of the input signal. Conclusion The ethylene signaling pathway cuts off very low and very high frequencies, allowing a window of frequency response in which the nucleus reads the incoming message as a sinusoidal input. Out of this window the nucleus reads the input message as an approximately non-varying one. From this frequency response analysis we estimate: a the gain of the system during the synthesis of the protein ERF1 (~-5.6 dB; b the rate of information transfer (0.003 bits during the transport of each new ERF1 molecule into the nucleus and c the time of synthesis of each new ERF1 molecule (~21.3 s. Finally, we demonstrate that in the case of the system of a single master gene (ERF1 and a single slave gene (HLS1, the total Shannon entropy is completely determined by the uncertainty associated with the expression of the master gene. A second proposition shows that the Shannon entropy

  9. Case study - Argentina

    International Nuclear Information System (INIS)

    Antecedents and experience of nuclear activities in Argentina; the Atomic Energy Commission (CNEA). First development and research activities. Research reactors and radioisotopes plants. Health physics and safety regulations. - Feasibility studies for the first nuclear power plant. Awarding the first plant CNA I (Atucha I). Relevant data related to the different project stages. Plant performance. - Feasibility study for the second nuclear power plant. Awarding the second plant CNE (Central Nuclear Embalse). Relevant data related to established targets. Differences compared with the first station targets. Local participation. Plant performance. (orig./GL)

  10. Final report on case studies

    DEFF Research Database (Denmark)

    Ljungberg, Daniel; McKelvey, Maureen; Lassen, Astrid Heidemann

    2012-01-01

    Case study as a research design means investigating a single or multiple instance(s) or setting(s) (i.e. a case) and its entire context to explain a phenomenon and its processes. This is achieved through detailed understanding, usually comprised of multiple sources of information. In this way, ca...

  11. Structural and Functional Studies of the Mitochondrial Cysteine Desulfurase from Arabidopsis thaliana

    Institute of Scientific and Technical Information of China (English)

    Valeria R; Turowski; Maria V.Busi; Diego F.Gomez-Casati

    2012-01-01

    AtNfs1 is the Arabidopsis thaliana mitochondrial homolog of the bacterial cysteine desulfurases NifS and lscS,having an essential role in cellular Fe-S cluster assembly.Homology modeling of AtNfs1m predicts a high global similarity with E.coli IscS showing a full conservation of residues involved in the catalytic site,whereas the chloroplastic AtNfs2 is more similar to the Synechocystis sp.SufS.Pull-down assays showed that the recombinant mature form,AtNfs1m,specifically binds to Arabidopsis frataxin (AtFH).A hysteretic behavior,with a lag phase of several minutes,was observed and hysteretic parameters were affected by pre-incubation with AtFH.Moreover,AtFH modulates AtNfs1m kinetics,increasing Vmax and decreasing the S0.5 value for cysteine.Results suggest that AtFH plays an important role in the early steps of Fe-S cluster formation by regulating AtNfs1 activity in olant mitochondria.

  12. Case Study: del Amo Bioventing

    Science.gov (United States)

    The attached presentation discusses the fundamentals of bioventing in the vadose zone. The basics of bioventing are presented. The experience to date with the del Amo Superfund Site is presented as a case study.

  13. Nasopharyngeal Case-Control Study

    Science.gov (United States)

    A case-control study conducted in Taiwan between 1991-1994 among approximately 1,000 individuals to examine the role of viral, environmental, and genetic factors associated with the development of nasopharyngeal carcinoma

  14. Advances in Arabidopsis research in China from 2006 to 2007

    Institute of Scientific and Technical Information of China (English)

    LIANG Yan; ZUO JianRu; YANG WeiCai

    2007-01-01

    @@ Arabidopsis thaliana, a model plant species, has a number of advantages over other plant species as an experimental organism due to many of its genetic and genomic features. The Chinese Arabidopsis community has made significant contributions to plant biology research in recent years[1,2]. In 2006, studies of plant biology in China received more attention than ever before, especially those pertaining to Arabidopsis research. Here we briefly summarize recent advances in Arabidopsis research in China.

  15. Protocols for Studying Protein Stability in an Arabidopsis Protoplast Transient Expression System.

    Science.gov (United States)

    Planchais, Séverine; Camborde, Laurent; Jupin, Isabelle

    2016-01-01

    Protein stability influences many aspects of biology, and measuring their stability in vivo can provide important insights into biological systems.This chapter describes in details two methods to assess the stability of a specific protein based on its transient expression in Arabidopsis protoplasts. First, a pulse-chase assay based on radioactive metabolic labeling of cellular proteins, followed by immunoprecipitation of the protein of interest. The decrease in radioactive signal is monitored over time and can be used to determine the protein's half-life.Alternatively, we also present a nonradioactive assay based on the use of reporter proteins, whose ratio can be quantified. This assay can be used to determine the relative stability of a protein of interest under specific conditions. PMID:27424754

  16. Ultrastructural study of maturing pollen in Arabidopsis thaliana (L. Heynh. (Brassicaceae

    Directory of Open Access Journals (Sweden)

    Krystyna Zając

    2014-02-01

    Full Text Available Ultrastructural changes in Arabidopsis thaliana pollen, between late microspore stage and mature pollen stage were described. When the generative cell was peeled off from the intine, it was of spherical shape and had all usual organelles with the exception of plastids. The cytoplasm transformation of the vegetative cell included an increase in the number of mitochondria and changes in the accumulation of starch and lipid bodies. The starch plastids were observed at the bicellular and early tricellular pollen stages and next starch was utilized during the maturation procces. The lipid bodies of the vegetative cell form a very regular sheath around the generative cell and then, around the sperm cells. Before anthesis the lipid bodies were dispersed within the whole vegetative cell cytoplasm.

  17. Sternocleidomastoid syndrome: a case study

    OpenAIRE

    Missaghi, Babak

    2004-01-01

    This article presents a case study of a patient diagnosed with dysfunction of the sternocleidomastoid (SCM) muscle, a condition which can result in head and face pain, nausea, dizziness, coryza, and lacrimation. In this particular case, the SCM muscle had developed tightness and weakness with presence of multiple trigger points within both heads. A combination of passive and active treatments were utilized to successfully treat this condition.

  18. Kenya Groundwater Governance Case Study

    OpenAIRE

    Mumma, Albert; Lane, Michael; Kairu, Edward; Tuinhof, Albert; Hirji, Rafik

    2011-01-01

    This report presents a case study on groundwater governance in Kenya. The objectives of the study were to: (a) describe groundwater resource and socioeconomic settings for four selected aquifers; (b) describe governance arrangements for groundwater management in Kenya; and (c) identify the relevance of these arrangements for planning and implementing climate change mitigation measures. The ...

  19. Gene Networks Involved in Hormonal Control of Root Development in Arabidopsis thaliana: A Framework for Studying Its Disturbance by Metal Stress.

    Science.gov (United States)

    De Smet, Stefanie; Cuypers, Ann; Vangronsveld, Jaco; Remans, Tony

    2015-01-01

    Plant survival under abiotic stress conditions requires morphological and physiological adaptations. Adverse soil conditions directly affect root development, although the underlying mechanisms remain largely to be discovered. Plant hormones regulate normal root growth and mediate root morphological responses to abiotic stress. Hormone synthesis, signal transduction, perception and cross-talk create a complex network in which metal stress can interfere, resulting in root growth alterations. We focus on Arabidopsis thaliana, for which gene networks in root development have been intensively studied, and supply essential terminology of anatomy and growth of roots. Knowledge of gene networks, mechanisms and interactions related to the role of plant hormones is reviewed. Most knowledge has been generated for auxin, the best-studied hormone with a pronounced primary role in root development. Furthermore, cytokinins, gibberellins, abscisic acid, ethylene, jasmonic acid, strigolactones, brassinosteroids and salicylic acid are discussed. Interactions between hormones that are of potential importance for root growth are described. This creates a framework that can be used for investigating the impact of abiotic stress factors on molecular mechanisms related to plant hormones, with the limited knowledge of the effects of the metals cadmium, copper and zinc on plant hormones and root development included as case example.

  20. A Study of the Blue-Light-Dependent Phosphorylation, Degradation, and Photobody Formation of Arabidopsis CRY2

    Institute of Scientific and Technical Information of China (English)

    Ze-Cheng Zuo; Ying-Ying Meng; Xu-Hong Yu; Zeng-Lin Zhang; De-Shun Feng; Shih-Fan Sun; Bin Liu; Chen-Tao Lin

    2012-01-01

    Arabidopsis cryptochrome 2 (CRY2) is a blue-light receptor mediating blue-light inhibition of hypocotyl elongation and photoperiodic promotion of floral initiation.CRY2 is a constitutive nuclear protein that undergoes blue-light-dependent phosphoryiation,ubiquitination,photobody formation,and degradation in the nucleus,but the relationship between these blue-light-dependent events remains unclear.it has been proposed that CRY2 phosphorylation triggers a conformational change responsible for the subsequent ubiquitination and photobody formation,leading to CRY2 function and/or degradation.We tested this hypothesis by a structure-function study,using mutant CRY2-GFP fusion proteins expressed in transgenic Arabidopsis.We show that changes of lysine residues of the NLS (Nuclear Localization Signal) sequence of CRY2 to arginine residues partially impair the nuclear importation of the CRY2K541R and CRY2K554/5R mutant proteins,resulting in reduced phosphorylation,physiological activities,and degradation in response to blue light.In contrast to the wild-type CRY2 protein that forms photobodies exclusively in the nucleus,the CRY2K541R and CRY2K554/5R mutant proteins form protein bodies in both the nucleus and cytosol in response to blue light.These results suggest that photoexcited CRY2 molecules can aggregate to form photobody-like structure without the nucleus-dependent protein modifications or the association with the nuclear CRY2-interacting proteins.Taken together,the observation that CRY2 forms photobodies markedly faster than CRY2 phosphorylation in response to blue light,we hypothesize that the photoexcited cryptochromes form oligomers,preceding other biochemical changes of CRY2,to facilitate photobody formation,signal amplification,and propagation,as well as desensitization by degradation.

  1. eCompetence Case Studies

    DEFF Research Database (Denmark)

    Jensen, Helle Bækkelund

    2006-01-01

    In this paper we present some details of the processes undertaken in the European eCompetence Initiative. We present two illustrative and representative case studies. The research aims to identify and understand patterns of individual and organisational eCompetence approaches.......In this paper we present some details of the processes undertaken in the European eCompetence Initiative. We present two illustrative and representative case studies. The research aims to identify and understand patterns of individual and organisational eCompetence approaches....

  2. Case Study on Logistics Performance

    Directory of Open Access Journals (Sweden)

    Shahryar Sorooshian

    2013-05-01

    Full Text Available The paper presents research carried out at a medium‐size manufacturing organization in east Asia. The study tries to highlight the importance of supply chain management; specifically, our aim for this study is to understand logistics and performance measurement in the logistics and supply chain, and we include a theoretical discussion of online data collected and a case study of the logistic performance of a real organization. The study also examines the performance of the selected company, identifies the problems and provides recommendations for improvements. This study can be a guide for business advisers and those interested in analysing company performance, especially from a logistics viewpoint. We also suggest the methodology of this case study for those who want to have a better understanding of a business environment before starting their own business, or for benchmarking practice during strategic planning.

  3. Case Studies in Sports Nutrition.

    Science.gov (United States)

    Clark, Nancy

    1988-01-01

    This article presents case studies of two athletes who wanted to affect a change in their body weight in order to enhance athletic performance. Each athlete's problem and the nutrition approach used to solve it are discussed. Caloric values of fast foods are listed. (JL)

  4. The reflexive case study method

    DEFF Research Database (Denmark)

    Rittenhofer, Iris

    2015-01-01

    This paper extends the international business research on small to medium-sized enterprises (SME) at the nexus of globalization. Based on a conceptual synthesis across disciplines and theoretical perspectives, it offers management research a reflexive method for case study research of postnational...

  5. Machine learning-based differential network analysis: a study of stress-responsive transcriptomes in Arabidopsis.

    Science.gov (United States)

    Ma, Chuang; Xin, Mingming; Feldmann, Kenneth A; Wang, Xiangfeng

    2014-02-01

    Machine learning (ML) is an intelligent data mining technique that builds a prediction model based on the learning of prior knowledge to recognize patterns in large-scale data sets. We present an ML-based methodology for transcriptome analysis via comparison of gene coexpression networks, implemented as an R package called machine learning-based differential network analysis (mlDNA) and apply this method to reanalyze a set of abiotic stress expression data in Arabidopsis thaliana. The mlDNA first used a ML-based filtering process to remove nonexpressed, constitutively expressed, or non-stress-responsive "noninformative" genes prior to network construction, through learning the patterns of 32 expression characteristics of known stress-related genes. The retained "informative" genes were subsequently analyzed by ML-based network comparison to predict candidate stress-related genes showing expression and network differences between control and stress networks, based on 33 network topological characteristics. Comparative evaluation of the network-centric and gene-centric analytic methods showed that mlDNA substantially outperformed traditional statistical testing-based differential expression analysis at identifying stress-related genes, with markedly improved prediction accuracy. To experimentally validate the mlDNA predictions, we selected 89 candidates out of the 1784 predicted salt stress-related genes with available SALK T-DNA mutagenesis lines for phenotypic screening and identified two previously unreported genes, mutants of which showed salt-sensitive phenotypes. PMID:24520154

  6. Study of biological effects induced in Arabidopsis thaliana following uranium exposure, including mixed exposure to cadmium or external gamma radiation: applying a multi-biomarkers approach

    OpenAIRE

    Vanhoudt, Nathalie

    2009-01-01

    The aim of this study was first to investigate uranium toxicity effects and to unravel mechanisms by which plants respond to uranium stress. In a next phase, the influence of secondary stressors on uranium induced effects was investigated. The highest uranium concentration of 100 µM uranium is extremely toxic for Arabidopsis thaliana plants with a completely inhibited growth, a fully disturbed nutrient profile, wilting and although making an effort to increase antioxidative defense, suffering...

  7. A case study of Impetigo

    Directory of Open Access Journals (Sweden)

    Mansouri P

    1993-05-01

    Full Text Available This is a report of a case study on 234 patients with impetigo who referred to Razi Dermatology Hospital from April to November, 1989. Treatment was started immediately after obtaining direct smear and performing culture and antibiotic sensitivity test. The most common organism responsible for impetigo was the coagulase-positive staphylococcus (71%. In 13.7% of the cases, the coagulase-negative staphylococcus was grown on culture media, but none of the cultures showed streptococcus as the main organism. Treatment was started with oral penicillin V, oral erythromycin, benzathine penicillin G injection, oral cephalexin, and topical fuccidin. Clinical and bacteriological evaluation after 3-7 days showed that it is preferable to use oral cephalexin instead of other protocols such as oral erythromycin, which has previously been the drug of choice for impetigo. In addition, topical fuccidin with a 75% curative rate was the first drug for treatment, with the same effect as the oral cephalexin

  8. Gene Network Analysis and Functional Studies of Senescence-associated Genes Reveal Novel Regulators of Arabidopsis Leaf Senescence

    Institute of Scientific and Technical Information of China (English)

    Zhonghai Li; Jinying Peng; Xing Wen; Hongwei Guo

    2012-01-01

    Plant leaf senescence has been recognized as the last phase of plant development,a highly ordered process regulated by genes known as senescence associated genes (SAGs).However,the function of most of SAGs in regulating leaf senescence as well as regulators of those functionally known SAGs are still unclear.We have previously developed a curated database of genes potentially associated with leaf senescence,the Leaf Senescence Database (LSD).In this study,we built gene networks to identify common regulators of leaf senescence in Arabidopsis thaliana using promoting or delaying senescence genes in LSD.Our results demonstrated that plant hormones cytokinin,auxin,nitric oxide as well as small molecules,such as Ca2+,delay leaf senescence.By contrast,ethylene,ABA,SA and JA as well as small molecules,such as oxygen,promote leaf senescence,altogether supporting the idea that phytohormones play a critical role in regulating leaf senescence.Functional analysis of candidate SAGs in LSD revealed that a WRKY transcription factor WRKY75 and a Cys2/His2-type transcription factor AZF2 are positive regulators of leaf senescence and loss-of-function of WRKY75 or AZF2 delayed leaf senescence.We also found that silencing of a protein phosphatase,AtMKP2,promoted early senescence.Collectively,LSD can serve as a comprehensive resource for systematic study of the molecular mechanism of leaf senescence as well as offer candidate genes for functional analyses.

  9. TEACHER BELIEFS: A CASE STUDY

    Institute of Scientific and Technical Information of China (English)

    HuYijie

    2004-01-01

    In recent years ELT has stressed the role which teachers' beliefs play in shaping what they do in the classroom. But so far as teaching English in China is concerned, we lack empirical insight into the relationship between teachers' beliefs and their classroom practice. With specific reference to the use of English in intensive reading classes, by presenting and discussing data from a case study of a non-native college English teacher,this exploratory qualitative classroom research sheds light on the nature of teachers' beliefs held consciously or unconsciously.Their subsequent change and impact on the classroom will also be reported and discussed.

  10. Phenotypic and chemotypic studies using Arabidopsis and yeast reveal that GHB converts to SSA and induce toxicity.

    Science.gov (United States)

    Mekonnen, Dereje Worku; Ludewig, Frank

    2016-07-01

    γ-Hydroxybutyric acid (GHB) is a naturally occurring compound. It is detected in organisms such as yeasts, plants and mammals. GHB is produced from the reduction of succinic semialdehyde (SSA) by the activity of GHB dehydrogenase. Arabidopsis genome contains two GHB dehydrogenase encoding genes. The accumulation of GHB in ssadh mutants led to the speculation that GHB is the cause of aberrant phenotypes. Conversely, the accumulation of GHB in Arabidopsis plants subjected to abiotic stresses was described as a way of avoiding SSA induced damage. To resolve these contrasting views on GHB, we examined the effect of exogenous GHB and SSA on the growth of yeast and Arabidopsis plants. GHB concentrations up to 1.5 mM didn't affect shoots of Arabidopsis plants; however, root growth was inhibited. In contrast, 0.3 mM SSA has severely affected the growth of plants. Treatment of yeast wild-type strain with 10 mM SSA and 10 mM GHB didn't affect the growth. However, the growth of yeast uga2 mutant was greatly inhibited by the same concentration of SSA, but not GHB. Metabolic analysis and enzyme activity assay on native gel showed that Arabidopsis, but not yeast, possesses a GHB dehydrogenase activity that converts GHB back to SSA. The enzymatic assay has also indicated the existence of an additional GHB dehydrogenase encoding gene(s) in Arabidopsis genome. Taken together, we conclude that GHB is less toxic than SSA. Its accumulation in ssadh mutants and during abiotic stresses is a response to avoid the SSA induced damage. PMID:27037708

  11. Phenotypic and chemotypic studies using Arabidopsis and yeast reveal that GHB converts to SSA and induce toxicity.

    Science.gov (United States)

    Mekonnen, Dereje Worku; Ludewig, Frank

    2016-07-01

    γ-Hydroxybutyric acid (GHB) is a naturally occurring compound. It is detected in organisms such as yeasts, plants and mammals. GHB is produced from the reduction of succinic semialdehyde (SSA) by the activity of GHB dehydrogenase. Arabidopsis genome contains two GHB dehydrogenase encoding genes. The accumulation of GHB in ssadh mutants led to the speculation that GHB is the cause of aberrant phenotypes. Conversely, the accumulation of GHB in Arabidopsis plants subjected to abiotic stresses was described as a way of avoiding SSA induced damage. To resolve these contrasting views on GHB, we examined the effect of exogenous GHB and SSA on the growth of yeast and Arabidopsis plants. GHB concentrations up to 1.5 mM didn't affect shoots of Arabidopsis plants; however, root growth was inhibited. In contrast, 0.3 mM SSA has severely affected the growth of plants. Treatment of yeast wild-type strain with 10 mM SSA and 10 mM GHB didn't affect the growth. However, the growth of yeast uga2 mutant was greatly inhibited by the same concentration of SSA, but not GHB. Metabolic analysis and enzyme activity assay on native gel showed that Arabidopsis, but not yeast, possesses a GHB dehydrogenase activity that converts GHB back to SSA. The enzymatic assay has also indicated the existence of an additional GHB dehydrogenase encoding gene(s) in Arabidopsis genome. Taken together, we conclude that GHB is less toxic than SSA. Its accumulation in ssadh mutants and during abiotic stresses is a response to avoid the SSA induced damage.

  12. Using correspondence analysis in multiple case studies

    NARCIS (Netherlands)

    Kienstra, N.H.H.; van der Heijden, P.G.M.

    2015-01-01

    In qualitative research of multiple case studies, Miles and Huberman proposed to summarize the separate cases in a so-called meta-matrix that consists of cases by variables. Yin discusses cross-case synthesis to study this matrix. We propose correspondence analysis (CA) as a useful tool to study thi

  13. Using Correspondence Analysis in Multiple Case Studies

    NARCIS (Netherlands)

    Kienstra, Natascha; van der Heijden, Peter G.M.

    2015-01-01

    In qualitative research of multiple case studies, Miles and Huberman proposed to summarize the separate cases in a so-called meta-matrix that consists of cases by variables. Yin discusses cross-case synthesis to study this matrix. We propose correspondence analysis (CA) as a useful tool to study thi

  14. A parathyroid scintigraphy case study

    Energy Technology Data Exchange (ETDEWEB)

    O' Leary, Desiree [UCD School of Diagnostic Imaging, St Anthony' s Campus, Herbert Avenue, Dublin 4 (Ireland)]. E-mail: desiree.oleary@ucd.ie

    2005-05-01

    Background: There has been much debate concerning the most suitable protocol for parathyroid scintigraphy; the merits of various radiopharmaceuticals versus the correct imaging protocol to visualise both ectopic and anatomically placed adenomas against the various equipment choices have been debated. Aim: To demonstrate, through the use of a case study, the necessity of changing imaging protocols for parathyroid scintigraphy where a definitive imaging diagnosis is absent in the face of strong clinical suspicion. Method: Use is made of Tc99mMIBI, full field chest scintigraphy, a clearly defined imaging protocol and SPECT imaging to locate ectopic parathyroid tissue in a female patient with significant symptoms of parathyroid hyperfunction. Results: A single hyperfunctioning adenoma is located in the pre-carinal area of the mediastinum. Using a radioguided surgical technique the hyperfunctioning tissue is excised and confirmed by histopathology. Conclusion: Whilst a dramatic reduction in patient symptoms was not seen immediately in this patient, the symptoms of the illness have been subsiding since January 2003. This case study demonstrates the necessity of changing imaging protocols for parathyroid scintigraphy where a definitive imaging diagnosis is absent in the face of strong clinical suspicion.

  15. Case Study: A Picture Worth a Thousand Words? Making a Case for Video Case Studies

    Science.gov (United States)

    Pai, Aditi

    2014-01-01

    A picture, they say, is worth a thousand words. If a mere picture is worth a thousand words, how much more are "moving pictures" or videos worth? The author poses this not merely as a rhetorical question, but because she wishes to make a case for using videos in the traditional case study method. She recommends four main approaches of…

  16. STS Case Study Development Support

    Science.gov (United States)

    Rosa de Jesus, Dan A.; Johnson, Grace K.

    2013-01-01

    The Shuttle Case Study Collection (SCSC) has been developed using lessons learned documented by NASA engineers, analysts, and contractors. The SCSC provides educators with a new tool to teach real-world engineering processes with the goal of providing unique educational materials that enhance critical thinking, decision-making and problem-solving skills. During this third phase of the project, responsibilities included: the revision of the Hyper Text Markup Language (HTML) source code to ensure all pages follow World Wide Web Consortium (W3C) standards, and the addition and edition of website content, including text, documents, and images. Basic HTML knowledge was required, as was basic knowledge of photo editing software, and training to learn how to use NASA's Content Management System for website design. The outcome of this project was its release to the public.

  17. KAIZEN – A case study

    Directory of Open Access Journals (Sweden)

    Manjunath Shettar

    2015-05-01

    Full Text Available The ultimate objective of manufacturing industries is to increase productivity with high quality. At present, many manufacturing companies are facing problems such as high quality rejection, high inventories, high lead time, high costs of production, and inability to cope with customer orders. By implementing and practicing the lean production system many problems can be solved without employing high-tech and high-touch approaches but by involving people on the shop floor in Kaizen activities. Kaizen is one of the powerful tools of lean manufacturing. Kaizen refers to continuous improvement in performance, cost and quality. Kaizen ensures that manufacturing processes become leaner and fitter, but eliminate waste (problem where value is added. The main objective of this paper is to provide a background on kaizen, present an overview of kaizen concepts that are used to transform a company into a high performing lean enterprise. A case study of implementation of Kaizen‟s has been discussed.

  18. MADS on the move : a study on MADS domain protein function and movement during floral development in Arabidopsis thaliana

    NARCIS (Netherlands)

    Urbanus, S.L.

    2010-01-01

    In this thesis we investigated the behaviour of fluorescently-tagged MADS domain proteins during floral development in the model plant Arabidopsis thaliana, and explored the importance of intercellular transport via plasmodesmata for MADS domain transcription factor functioning. The MADS domain tran

  19. Using Case Studies To Teach Science.

    Science.gov (United States)

    Gabel, Connie

    Using case studies in science instruction develops problem solving and enhances listening and cooperative learning skills. Unlike other disciplines such as law and medicine, the case study method is rarely used in science education to enrich the curriculum. This study investigates the use of content-based case studies as a means of developing…

  20. Arabidopsis thaliana DM2h (R8) within the Landsberg RPP1-like Resistance Locus Underlies Three Different Cases of EDS1-Conditioned Autoimmunity

    Science.gov (United States)

    Garcia, Ana V.; Wagner, Christine; Choudhury, Sayan R.; Wang, Yiming; James, Geo Velikkakam; Griebel, Thomas; Alcázar, Ruben; Tsuda, Kenichi; Schneeberger, Korbinian; Parker, Jane E.

    2016-01-01

    Plants have a large panel of nucleotide-binding/leucine rich repeat (NLR) immune receptors which monitor host interference by diverse pathogen molecules (effectors) and trigger disease resistance pathways. NLR receptor systems are necessarily under tight control to mitigate the trade-off between induced defenses and growth. Hence, mis-regulated NLRs often cause autoimmunity associated with stunting and, in severe cases, necrosis. Nucleocytoplasmic ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1) is indispensable for effector-triggered and autoimmune responses governed by a family of Toll-Interleukin1-Receptor-related NLR receptors (TNLs). EDS1 operates coincidently or immediately downstream of TNL activation to transcriptionally reprogram cells for defense. We show here that low levels of nuclear-enforced EDS1 are sufficient for pathogen resistance in Arabidopsis thaliana, without causing negative effects. Plants expressing higher nuclear EDS1 amounts have the genetic, phenotypic and transcriptional hallmarks of TNL autoimmunity. In a screen for genetic suppressors of nuclear EDS1 autoimmunity, we map multiple, independent mutations to one gene, DM2h, lying within the polymorphic DANGEROUS MIX2 cluster of TNL RPP1-like genes from A. thaliana accession Landsberg erecta (Ler). The DM2 locus is a known hotspot for deleterious epistatic interactions leading to immune-related incompatibilities between A. thaliana natural accessions. We find that DM2hLer underlies two further genetic incompatibilities involving the RPP1-likeLer locus and EDS1. We conclude that the DM2hLer TNL protein and nuclear EDS1 cooperate, directly or indirectly, to drive cells into an immune response at the expense of growth. A further conclusion is that regulating the available EDS1 nuclear pool is fundamental for maintaining homeostatic control of TNL immune pathways. PMID:27082651

  1. Arabidopsis thaliana DM2h (R8) within the Landsberg RPP1-like Resistance Locus Underlies Three Different Cases of EDS1-Conditioned Autoimmunity.

    Science.gov (United States)

    Stuttmann, Johannes; Peine, Nora; Garcia, Ana V; Wagner, Christine; Choudhury, Sayan R; Wang, Yiming; James, Geo Velikkakam; Griebel, Thomas; Alcázar, Ruben; Tsuda, Kenichi; Schneeberger, Korbinian; Parker, Jane E

    2016-04-01

    Plants have a large panel of nucleotide-binding/leucine rich repeat (NLR) immune receptors which monitor host interference by diverse pathogen molecules (effectors) and trigger disease resistance pathways. NLR receptor systems are necessarily under tight control to mitigate the trade-off between induced defenses and growth. Hence, mis-regulated NLRs often cause autoimmunity associated with stunting and, in severe cases, necrosis. Nucleocytoplasmic ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1) is indispensable for effector-triggered and autoimmune responses governed by a family of Toll-Interleukin1-Receptor-related NLR receptors (TNLs). EDS1 operates coincidently or immediately downstream of TNL activation to transcriptionally reprogram cells for defense. We show here that low levels of nuclear-enforced EDS1 are sufficient for pathogen resistance in Arabidopsis thaliana, without causing negative effects. Plants expressing higher nuclear EDS1 amounts have the genetic, phenotypic and transcriptional hallmarks of TNL autoimmunity. In a screen for genetic suppressors of nuclear EDS1 autoimmunity, we map multiple, independent mutations to one gene, DM2h, lying within the polymorphic DANGEROUS MIX2 cluster of TNL RPP1-like genes from A. thaliana accession Landsberg erecta (Ler). The DM2 locus is a known hotspot for deleterious epistatic interactions leading to immune-related incompatibilities between A. thaliana natural accessions. We find that DM2hLer underlies two further genetic incompatibilities involving the RPP1-likeLer locus and EDS1. We conclude that the DM2hLer TNL protein and nuclear EDS1 cooperate, directly or indirectly, to drive cells into an immune response at the expense of growth. A further conclusion is that regulating the available EDS1 nuclear pool is fundamental for maintaining homeostatic control of TNL immune pathways.

  2. Arabidopsis thaliana DM2h (R8 within the Landsberg RPP1-like Resistance Locus Underlies Three Different Cases of EDS1-Conditioned Autoimmunity.

    Directory of Open Access Journals (Sweden)

    Johannes Stuttmann

    2016-04-01

    Full Text Available Plants have a large panel of nucleotide-binding/leucine rich repeat (NLR immune receptors which monitor host interference by diverse pathogen molecules (effectors and trigger disease resistance pathways. NLR receptor systems are necessarily under tight control to mitigate the trade-off between induced defenses and growth. Hence, mis-regulated NLRs often cause autoimmunity associated with stunting and, in severe cases, necrosis. Nucleocytoplasmic ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1 is indispensable for effector-triggered and autoimmune responses governed by a family of Toll-Interleukin1-Receptor-related NLR receptors (TNLs. EDS1 operates coincidently or immediately downstream of TNL activation to transcriptionally reprogram cells for defense. We show here that low levels of nuclear-enforced EDS1 are sufficient for pathogen resistance in Arabidopsis thaliana, without causing negative effects. Plants expressing higher nuclear EDS1 amounts have the genetic, phenotypic and transcriptional hallmarks of TNL autoimmunity. In a screen for genetic suppressors of nuclear EDS1 autoimmunity, we map multiple, independent mutations to one gene, DM2h, lying within the polymorphic DANGEROUS MIX2 cluster of TNL RPP1-like genes from A. thaliana accession Landsberg erecta (Ler. The DM2 locus is a known hotspot for deleterious epistatic interactions leading to immune-related incompatibilities between A. thaliana natural accessions. We find that DM2hLer underlies two further genetic incompatibilities involving the RPP1-likeLer locus and EDS1. We conclude that the DM2hLer TNL protein and nuclear EDS1 cooperate, directly or indirectly, to drive cells into an immune response at the expense of growth. A further conclusion is that regulating the available EDS1 nuclear pool is fundamental for maintaining homeostatic control of TNL immune pathways.

  3. Catalog of NASA-Related Case Studies

    Data.gov (United States)

    National Aeronautics and Space Administration — The OCKO has developed over 50 case studies to enhance learning at workshops, training, retreats and conferences. Case studies make mission knowledge attractive and...

  4. Computational Study of the Binding Mechanism of Actin-Depolymerizing Factor 1 with Actin in Arabidopsis thaliana.

    Science.gov (United States)

    Du, Juan; Wang, Xue; Dong, Chun-Hai; Yang, Jian Ming; Yao, Xiao Jun

    2016-01-01

    Actin is a highly conserved protein. It plays important roles in cellular function and exists either in the monomeric (G-actin) or polymeric form (F-actin). Members of the actin-depolymerizing factor (ADF)/cofilin protein family bind to both G-actin and F-actin and play vital roles in actin dynamics by manipulating the rates of filament polymerization and depolymerization. It has been reported that the S6D and R98A/K100A mutants of actin-depolymerizing factor 1 (ADF1) in Arabidopsis thaliana decreased the binding affinity of ADF for the actin monomer. To investigate the binding mechanism and dynamic behavior of the ADF1-actin complex, we constructed a homology model of the AtADF1-actin complex based on the crystal structure of AtADF1 and the twinfilin C-terminal ADF-H domain in a complex with a mouse actin monomer. The model was then refined for subsequent molecular dynamics simulations. Increased binding energy of the mutated system was observed using the Molecular Mechanics Generalized Born Surface Area and Poisson-Boltzmann Surface Area (MM-GB/PBSA) methods. To determine the residues that make decisive contributions to the ADF1 actin-binding affinity, per-residue decomposition and computational alanine scanning analyses were performed, which provided more detailed information on the binding mechanism. Root-mean-square fluctuation and principal component analyses confirmed that the S6D and R98A/K100A mutants induced an increased conformational flexibility. The comprehensive molecular insight gained from this study is of great importance for understanding the binding mechanism of ADF1 and G-actin. PMID:27414648

  5. Acyl chains of phospholipase D transphosphatidylation products in Arabidopsis cells: a study using multiple reaction monitoring mass spectrometry.

    Directory of Open Access Journals (Sweden)

    Dominique Rainteau

    Full Text Available BACKGROUND: Phospholipases D (PLD are major components of signalling pathways in plant responses to some stresses and hormones. The product of PLD activity is phosphatidic acid (PA. PAs with different acyl chains do not have the same protein targets, so to understand the signalling role of PLD it is essential to analyze the composition of its PA products in the presence and absence of an elicitor. METHODOLOGY/PRINCIPAL FINDINGS: Potential PLD substrates and products were studied in Arabidopsis thaliana suspension cells treated with or without the hormone salicylic acid (SA. As PA can be produced by enzymes other than PLD, we analyzed phosphatidylbutanol (PBut, which is specifically produced by PLD in the presence of n-butanol. The acyl chain compositions of PBut and the major glycerophospholipids were determined by multiple reaction monitoring (MRM mass spectrometry. PBut profiles of untreated cells or cells treated with SA show an over-representation of 160/18:2- and 16:0/18:3-species compared to those of phosphatidylcholine and phosphatidylethanolamine either from bulk lipid extracts or from purified membrane fractions. When microsomal PLDs were used in in vitro assays, the resulting PBut profile matched exactly that of the substrate provided. Therefore there is a mismatch between the acyl chain compositions of putative substrates and the in vivo products of PLDs that is unlikely to reflect any selectivity of PLDs for the acyl chains of substrates. CONCLUSIONS: MRM mass spectrometry is a reliable technique to analyze PLD products. Our results suggest that PLD action in response to SA is not due to the production of a stress-specific molecular species, but that the level of PLD products per se is important. The over-representation of 160/18:2- and 16:0/18:3-species in PLD products when compared to putative substrates might be related to a regulatory role of the heterogeneous distribution of glycerophospholipids in membrane sub-domains.

  6. Concentrated photovoltaics, a case study

    Directory of Open Access Journals (Sweden)

    Antonini Piergiorgio

    2014-01-01

    Full Text Available Concentrated Photovoltaics (CPV, once a niche technology, has now reached the maturity and reliability for large scale power generation. Especially in regions where temperatures are very high, the use of high efficiency triple junction solar cells with concentrating optics allows stable energy yield. Thus CPV can be seen as complementary and not in concurrence with silicon photovoltaics. The state of the art, the advantages and limitations of this technology will be shown. Among the main advantages of CPV is the possibility of a much higher energy supply, when compared to silicon photovoltaics, both comparing CPV and silicon with same area or the same installed power. The use of recycled and recyclable materials allows a more environmentally friendly production. The possibility to couple CPV with desalination facilities, energy storage will be analysed. As an example a case study of a CPV installation in Northern Italy is discussed. Here the use of mature technologies, derived from automotive and lighting sectors resulted in a simple and efficient module.

  7. Numerical and structural chromosome aberrations in cauliflower (Brassica oleracea var. botrytis) and Arabidopsis thaliana

    NARCIS (Netherlands)

    Ji, X.

    2014-01-01

    Numerical and structural chromosome aberrations in cauliflower (Brassica oleracea var. botrytis) and Arabidopsis thaliana. I studied numerical and structural chromosome aberrations in cauliflower (Brassica oleracea var. botrytis) and Arabidopsis thaliana. The large genomic changes are important for

  8. A HARD CHOICE (CASE STUDY)

    OpenAIRE

    KRAVCHENKO NATALIYA A.; KUZNETSOVA SVETLANA A.

    2014-01-01

    The case describes the problems of strategic choice: a small company successfully working in the engineering market (automation of technological processes) in the electric power industry has to make a decision on its further development in a changing external environment and increased competition. The case was carried out to be used in training programs of different levels within the courses “Strategic Management”, “Innovation Management”, “Strategic Analysis Methods”, “Change Management” whe...

  9. A rapid and efficient method to study the function of crop plant transporters in Arabidopsis

    Science.gov (United States)

    Iron (Fe) is an essential micronutrient for humans. Fe deficiency disease is wide-spread and has lead to extensive studies on the mechanisms of Fe uptake and storage, especially in staple food crops such as rice. However, studies of functionally related genes in rice and other crops are often time a...

  10. Five misunderstandings about case study research

    DEFF Research Database (Denmark)

    Flyvbjerg, Bent

    2004-01-01

    This article examines five common misunderstandings about case-study research: (1) Theoretical knowledge is more valuable than practical knowledge; (2) One cannot generalize from a single case, therefore the single case study cannot contribute to scientific development; (3) The case study is most...... useful for generating hypotheses, while other methods aremore suitable for hypotheses testing and theory building; (4) The case study contains a bias toward verification; and (5) It is often difficult to summarize specific case studies. The article explains and corrects these misunderstandings one by one...... and concludes with the Kuhnian insight that a scientific discipline without a large number of thoroughly executed case studies is a discipline without systematic production of exemplars, and that a discipline without exemplars is an ineffective one. Social science may be strengthened by the execution of more...

  11. Five misunderstandings about Case-study Research

    DEFF Research Database (Denmark)

    Flyvbjerg, Bent

    This article examines five common misunderstandings about case-study research: (1) Theoretical knowledge is more valuable than practical knowledge; (2) One cannot generalize from a single case, therefore the single case study cannot contribute to scientific development; (3) The case study is most...... useful for generating hypotheses, while other methods aremore suitable for hypotheses testing and theory building; (4) The case study contains a bias toward verification; and (5) It is often difficult to summarize specific case studies. The article explains and corrects these misunderstandings one by one...... and concludes with the Kuhnian insight that a scientific discipline without a large number of thoroughly executed case studies is a discipline without systematic production of exemplars, and that a discipline without  exemplars is an ineffective one. Social science may be strengthened by the execution of more...

  12. Five Misunderstandings About Case-Study Research

    DEFF Research Database (Denmark)

    Flyvbjerg, Bent

    2006-01-01

    This article examines five common misunderstandings about case-study research: (a) theoretical knowledge is more valuable than practical knowledge; (b) one cannot generalize from a single case, therefore, the single-case study cannot contribute to scientific development; (c) the case study is most...... useful for generating hypotheses, whereas other methods are more suitable for hypotheses testing and theory building; (d) the case study contains a bias toward verification; and (e) it is often difficult to summarize specific case studies. This article explains and corrects these misunderstandings one...... by one and concludes with the Kuhnian insight that a scientific discipline without a large number of thoroughly executed case studies is a discipline without systematic production of exemplars, and a discipline without exemplars is an ineffective one. Social science may be strengthened by the execution...

  13. Transanal rectopexy - twelve case studies

    Directory of Open Access Journals (Sweden)

    Rubens Henrique Oleques Fernandes

    2012-06-01

    Full Text Available OBJECTIVES: This study analyzed the results of transanal rectopexy and showed the benefits of this surgical technique. METHOD: Twelve patients were submitted to rectopexy between 1997 and 2011. The surgical technique used was transanal rectopexy, where the mesorectum was fixed to the sacrum with nonabsorbable suture. Three patients had been submitted to previous surgery, two by the Delorme technique and one by the Thiersch technique. RESULTS: Postoperative hospital stay ranged from 1 to 4 days. One patient (8.3% had intraoperative hematoma, which was treated with local compression and antibiotics. One patient (8.3% had residual mucosal prolapse, which was resected. Prolapse recurrence was seen in one case (8.3%. Improved incontinence occurred in 75% of patients and one patient reported obstructed evacuation in the first month after surgery. No death occurred. CONCLUSION: Transanal rectopexy is a simple, low cost technique, which has shown good efficacy in rectal prolapse control.OBJETIVO: O presente estudo analisou os resultados da retopexia pela via transanal e expôs os benefícios desta técnica cirúrgica. MÉTODO: Doze pacientes com prolapso foram operados no período de 1997 a 2011. A técnica cirúrgica usada foi a retopexia transanal, onde o mesorreto foi fixado ao sacro com fio inabsorvível. Três pacientes tinham cirurgia prévia, dois pela técnica de Delorme e um pela técnica de Thiersch. RESULTADOS: A permanência hospitalar pós-operatória variou de 1- 4 dias. Uma paciente (8,3% apresentou hematoma transoperatório que foi tratado com compressão local e antibioticoterapia. Um paciente apresentou prolapso mucoso residual (8,3%, que foi ressecado. Houve recidiva da procidência em um caso (8,3%. A melhora da incontinência ocorreu em 75% dos pacientes e uma paciente apresentou bloqueio evacuatório no primeiro mês após a cirurgia. Não houve mortalidade entre os pacientes operados. CONCLUSÃO: A retopexia transanal é uma t

  14. Arabidopsis thaliana—Aphid Interaction

    OpenAIRE

    Louis, Joe; Singh, Vijay,; Shah, Jyoti

    2012-01-01

    Aphids are important pests of plants that use their stylets to tap into the sieve elements to consume phloem sap. Besides the removal of photosynthates, aphid infestation also alters source-sink patterns. Most aphids also vector viral diseases. In this chapter, we will summarize on recent significant findings in plant-aphid interaction, and how studies involving Arabidopsis thaliana and Myzus persicae (Sülzer), more commonly known as the green peach aphid (GPA), are beginning to provide impor...

  15. Drive Electric Vermont Case Study

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Fred [Energetics Incorporated, Columbia, MD (United States); Roberts, Dave [Vermont Energy Investment Corporation (VEIC), Burlington, VT (United States); Francfort, Jim [Idaho National Lab. (INL), Idaho Falls, ID (United States); White, Sera [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-03-01

    Currently in the United States, the heavy majority of plug-in electric vehicle (PEV) sales have been in highly conducive, selected, metropolitan areas; opposed to more broad distribution across the country. The U.S. Department of Energy’s EV Everywhere Grand Challenge is looking carefully at the barriers and opportunities that exist to enable small and midsize communities to partake in the PEV market and benefit from the economic and environmental advantages of PEVs. In order to gain insight into these challenges and barriers, DOE selected a success story (i.e., Drive Electric Vermont) as the subject of this case study, as the state of Vermont is tied with Detroit, Michigan in having the highest percentage of 2014 (most recent complete data) PEV registrations for cold weather U.S. cities and has seen more than a sixfold increase in charging stations over the last three years. The overall objective of this case study was to use the lessons learned from Drive Electric Vermont to determine what activities are most effective at encouraging acquisitions of PEVs and deployment of charging infrastructure in small to midsize communities, prioritizing and sequencing their implementation, identifying robust means for extrapolation, and applying this understanding to other small to midsize communities across the nation. The Drive Electric Vermont Program was formed in 2012 with a goal of increasing the use of electrified transportation in Vermont through policy development, education and outreach, and infrastructure development. The Drive Electric Vermont Program can be broadly broken into four components: (1) strategic planning/leadership, (2) stakeholder/partnership development, (3) education and outreach, and (4) incentives. The early phases of the program focused heavily on strategic planning, and stakeholder and partnership development, followed by a transition to education and outreach activities, charging infrastructure development, and grant and incentive programs

  16. Drive Electric Vermont Case Study

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Fred [Energetics Incorporated, Columbia, MD (United States); Roberts, Dave [Vermont Energy Investment Corporation (VEIC), Burlington, VT (United States); Francfort, Jim [Idaho National Lab. (INL), Idaho Falls, ID (United States); White, Sera [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-03-01

    Currently in the United States, the heavy majority of plug-in electric vehicle (PEV) sales have been in highly conducive, selected, metropolitan areas; opposed to more broad distribution across the country. The U.S. Department of Energy’s EV Everywhere Grand Challenge is looking carefully at the barriers and opportunities that exist to enable small and midsize communities to partake in the PEV market and benefit from the economic and environmental advantages of PEVs. In order to gain insight into these challenges and barriers, DOE selected a success story (i.e., Drive Electric Vermont) as the subject of this case study, as the state of Vermont is tied with Detroit, Michigan in having the highest percentage of 2014 (most recent complete data) PEV registrations for cold weather U.S. cities and has seen more than a sixfold increase in charging stations over the last three years. The overall objective of this case study was to use the lessons learned from Drive Electric Vermont to determine what activities are most effective at encouraging acquisitions of PEVs and deployment of charging infrastructure in small to midsize communities, prioritizing and sequencing their implementation, identifying robust means for extrapolation, and applying this understanding to other small to midsize communities across the nation. The Drive Electric Vermont Program was formed in 2012 with a goal of increasing the use of electrified transportation in Vermont through policy development, education and outreach, and infrastructure development. The Drive Electric Vermont Program can be broadly broken into four components: (1) strategic planning/leadership, (2) stakeholder/partnership development, (3) education and outreach, and (4) incentives. The early phases of the program focused heavily on strategic planning, and stakeholder and partnership development, followed by a transition to education and outreach activities, charging infrastructure development, and grant and incentive programs

  17. Engineering carpel-specific cold stress tolerance: a case study in Arabidopsis

    Science.gov (United States)

    Freezing temperatures during winter generally do not injure floral buds of horticulturally important crops. Entry into dormancy coupled with cold acclimation provides adequate protection unless the temperatures are exceptionally low. This measure of protection is lost in spring when the floral bud...

  18. Roadmaster Roading Contractors Case Study

    Directory of Open Access Journals (Sweden)

    Hazel Taylor

    1999-01-01

    Full Text Available Systems analysis students seldom experience the practical difficulties of the initial investigation into a client’s requirements. They get little chance to practice the skills they need to investigate complex and confused problem situations, or to appreciate the wider organizational issues that can impact on a situation. This teaching case is designed to give students the opportunity to practice and apply investigation skills and to challenge them to consider the wider work environment when considering possible solutions to a problem situation. The case is conducted as a role-play, with students acting as systems analysts and teaching staff role-playing the clients. The students develop a report analyzing the client’s situation based on the issues that arise during the interviews. Feed-back sessions focus on discussing how well the students applied various interviewing strategies previously covered in lectures, and on the wider organizational problems that could impact proposed information system solutions.

  19. Study on Case Teaching of Financial Management

    Science.gov (United States)

    Che, Zhenghong; Che, Zhengmei

    2011-01-01

    Case teaching is an efficient teaching method of management. It plays an important role to enhance the students' ability to practice the theory. However, case teaching of financial management has not achieved the expected results. The paper aims to study the importance, characteristics and corresponding methods of case teaching method of financial…

  20. Associative visual agnosia: a case study.

    Science.gov (United States)

    Charnallet, A; Carbonnel, S; David, D; Moreaud, O

    2008-01-01

    We report a case of massive associative visual agnosia. In the light of current theories of identification and semantic knowledge organization, a deficit involving both levels of structural description system and visual semantics must be assumed to explain the case. We suggest, in line with a previous case study, an alternative account in the framework of (non abstractive) episodic models of memory.

  1. Asparagine Metabolic Pathways in Arabidopsis.

    Science.gov (United States)

    Gaufichon, Laure; Rothstein, Steven J; Suzuki, Akira

    2016-04-01

    Inorganic nitrogen in the form of ammonium is assimilated into asparagine via multiple steps involving glutamine synthetase (GS), glutamate synthase (GOGAT), aspartate aminotransferase (AspAT) and asparagine synthetase (AS) in Arabidopsis. The asparagine amide group is liberated by the reaction catalyzed by asparaginase (ASPG) and also the amino group of asparagine is released by asparagine aminotransferase (AsnAT) for use in the biosynthesis of amino acids. Asparagine plays a primary role in nitrogen recycling, storage and transport in developing and germinating seeds, as well as in vegetative and senescence organs. A small multigene family encodes isoenzymes of each step of asparagine metabolism in Arabidopsis, except for asparagine aminotransferase encoded by a single gene. The aim of this study is to highlight the structure of the genes and encoded enzyme proteins involved in asparagine metabolic pathways; the regulation and role of different isogenes; and kinetic and physiological properties of encoded enzymes in different tissues and developmental stages. PMID:26628609

  2. Academic Planning: Four Institutional Case Studies.

    Science.gov (United States)

    Kieft, Raymond N.

    As part of a project studying intrainstitutional planning, management, and evaluation, four case studies were undertaken in 1976 of academic planning at Villa Maria College, Kansas City Metropolitan Community College District, West Virginia University, and Western Washington University. The case studies were part of an ongoing project, the…

  3. Liverpool Telecare Pilot: case studies

    Directory of Open Access Journals (Sweden)

    Nigel Barnes

    2006-09-01

    Full Text Available Telecare services use information and communications technology (ICT to support the provision of care to people in their own homes. This paper describes a pilot telecare service employed by Liverpool (UK City Council to support a sample of their frail and elderly social services users. The pilot has been running for over two years and has been deployed for 21 individuals in Liverpool. In this paper we present the pilot system and provide real example cases which help to illustrate the benefits of such a system.

  4. Co-localisation studies of Arabidopsis SR splicing factors reveal different types of speckles in plant cell nuclei

    International Nuclear Information System (INIS)

    SR proteins are multidomain splicing factors which are important for spliceosome assembly and for regulation of alternative splicing. In mammalian nuclei these proteins localise to speckles from where they are recruited to transcription sites. By using fluorescent protein fusion technology and different experimental approaches it has been shown that Arabidopsis SR proteins, in addition to diffuse nucleoplasmic staining, localise into an irregular nucleoplasmic network resembling speckles in mammalian cells. As Arabidopsis SR proteins fall into seven conserved sub-families we investigated co-localisation of members of the different sub-families in transiently transformed tobacco protoplast. Here we demonstrate the new finding that members of different SR protein sub-families localise into distinct populations of nuclear speckles with no, partial or complete co-localisation. This is particularly interesting as we also show that these proteins do interact in a yeast two-hybrid assay as well as in pull-down and in co-immunopreciptiation assays. Our data raise the interesting possibility that SR proteins are partitioned into distinct populations of nuclear speckles to allow a more specific recruitment to the transcription/pre-mRNA processing sites of particular genes depending on cell type and developmental stage

  5. Five case studies of multifamily weatherization programs

    Energy Technology Data Exchange (ETDEWEB)

    Kinney, L; Wilson, T.; Lewis, G. [Synertech Systems Corp. (United States); MacDonald, M. [Oak Ridge National Lab., TN (United States)

    1997-12-31

    The multifamily case studies that are the subject of this report were conducted to provide a better understanding of the approach taken by program operators in weatherizing large buildings. Because of significant variations in building construction and energy systems across the country, five states were selected based on their high level of multifamily weatherization. This report summarizes findings from case studies conducted by multifamily weatherization operations in five cities. The case studies were conducted between January and November 1994. Each of the case studies involved extensive interviews with the staff of weatherization subgrantees conducting multifamily weatherization, the inspection of 4 to 12 buildings weatherized between 1991 and 1993, and the analysis of savings and costs. The case studies focused on innovative techniques which appear to work well.

  6. Summary of case studies for cooperation mechanisms

    DEFF Research Database (Denmark)

    Longa, Francesco Dalla; Klinge Jacobsen, Henrik; Hansen, Lise-Lotte Pade;

    2012-01-01

    This document is a summary report highlighting the main aspect analyzed in the RES4LESS case studies. The document starts with an introductory chapter where the background that led to the selection of the case studies is outlined. In the following three chapters the case studies are presented......, highlighting the most relevant results. A brief chapter concludes the document, giving an outlook on the follow-up activities of the RES4LESS project. This summary is intended not only as an introduction to the RES4LESS cases studies, but also as a guideline to read and interpret the in-depth analysis carried...... out in the final documents that describe the case studies in detail. These documents will be published in September 2012 on the RES4LESS website, www.res4less.eu....

  7. Regional case studies--Africa.

    Science.gov (United States)

    Prentice, Andrew M

    2009-01-01

    Africa is the final continent to be affected by the nutrition transition and, as elsewhere, is characterized by the paradoxical coexistence of malnutrition and obesity. Several features of the obesity epidemic in Africa mirror those in other emerging nations: it penetrates the richer nations and urban areas first with a strong urban- rural gradient; initially it affects the wealthy, but later there is a demographic switch as obesity becomes a condition more associated with poverty, and it shares many of the same drivers related to the increasing affordability of highly refined oils and carbohydrates, and a move away from subsistence farm work and towards sedentary lifestyles. Africa also has some characteristics of the obesity epidemic that stand out from other regions such as: (1) excepting some areas of the Pacific, Africa is probably the only region in which obesity (especially among women) is viewed culturally as a positive and desirable trait, leading to major gender differences in obesity rates in many countries; (2) most of Africa has very low rates of obesity in children, and to date African obesity is mostly an adult syndrome; (3) Africans seem genetically prone to higher rates of diabetes and hypertension in association with obesity than Caucasians, but seem to be relatively protected from dislipidemias; (4) the case-specific deaths and disabilities from diabetes and hypertension in Africa are very high due to the paucity of health services and the strain that the 'double burden' of disease places on health systems.

  8. Leishmaniasis in dogs: Case study

    Directory of Open Access Journals (Sweden)

    Aleksić Jelena

    2009-01-01

    Full Text Available The paper presents a case of leishmaniasis in a 2.5-month-old dog imported from France. The clinical examination established a generally poor state of health, expressed cachexia, atrophy of the temporal musculature, weakness of movement, as well as abnormally long and brittle nails. There was also hyperkeratosis of the nose tip and paws. A histological examination of biopsy sections of the altered skin parts showed inflammatory changes in the area of the dermis, together with infiltration of macrophages and a smaller number of lymphocytes, plasmocytes and neutrophil granulocytes in the area around the sebaceous glands and hair follicles. The determined changes correspond to superficial dermatitis. Edema followed by partial degeneration of connective-tissue fibers is observed in connective tissue. A smaller number of intracellular parasitic forms was established in mononuclear cells. A smaller number of oval amastigotes with round dark red nucleis were observed in sections stained using the Gimza method in the cytoplasm of macrophages located in the dermis, but also extracellularly. It was concluded that the dog was diseased with leishmaniasis on the grounds of the clinical picture and the microscopic findings.

  9. Rebranding: a Case Study Approach

    OpenAIRE

    Size, Maria, (Thesis)

    2005-01-01

    The primary objective of this study is to explore how and why companies implement rebranding campaigns. The study stemmed from a realisation by the author that the area of rebranding is very much under-researched academically although anecdotal evidence indicates and increase in the occurrence of the phenomenon in recent years. Therefore the purpose of this research is to add to the insufficient body of literature on rebranding through exploring it from a corporate perspective. The two chapte...

  10. Outage management: A case study

    International Nuclear Information System (INIS)

    Outage management issues identified from a field study conducted at a two-unit commercial pressurized water reactor (PWR), when one unit was in a refueling outage and the other unit was at full power operation, are the focus of this paper. The study was conduced as part of the US Nuclear Regulatory Commission's (NRC) organizational factors research program, and therefore the issues to be addressed are from an organizational perspective. Topics discussed refer to areas identified by the NRC as critical for safety during shutdown operations, including outage planning and control, personnel stress, and improvements in training and procedures. Specifically, issues in communication, management attention, involvement and oversight, administrative processes, organizational culture, and human resources relevant to each of the areas are highlighted by example from field data collection. Insights regarding future guidance in these areas are presented based upon additional data collection subsequent to the original study

  11. Outage management: A case study

    Energy Technology Data Exchange (ETDEWEB)

    Haber, S.B.; Barriere, M.T. (Brookhaven National Lab., Upton, NY (United States)); Roberts, K.H. (California Univ., Berkeley, CA (United States). Walter A. Haas School of Business)

    1992-01-01

    Outage management issues identified from a field study conducted at a two-unit commercial pressurized water reactor (PWR), when one unit was in a refueling outage and the other unit was at full power operation, are the focus of this paper. The study was conduced as part of the US Nuclear Regulatory Commission's (NRC) organizational factors research program, and therefore the issues to be addressed are from an organizational perspective. Topics discussed refer to areas identified by the NRC as critical for safety during shutdown operations, including outage planning and control, personnel stress, and improvements in training and procedures. Specifically, issues in communication, management attention, involvement and oversight, administrative processes, organizational culture, and human resources relevant to each of the areas are highlighted by example from field data collection. Insights regarding future guidance in these areas are presented based upon additional data collection subsequent to the original study.

  12. Outage management: A case study

    Energy Technology Data Exchange (ETDEWEB)

    Haber, S.B.; Barriere, M.T. [Brookhaven National Lab., Upton, NY (United States); Roberts, K.H. [California Univ., Berkeley, CA (United States). Walter A. Haas School of Business

    1992-09-01

    Outage management issues identified from a field study conducted at a two-unit commercial pressurized water reactor (PWR), when one unit was in a refueling outage and the other unit was at full power operation, are the focus of this paper. The study was conduced as part of the US Nuclear Regulatory Commission`s (NRC) organizational factors research program, and therefore the issues to be addressed are from an organizational perspective. Topics discussed refer to areas identified by the NRC as critical for safety during shutdown operations, including outage planning and control, personnel stress, and improvements in training and procedures. Specifically, issues in communication, management attention, involvement and oversight, administrative processes, organizational culture, and human resources relevant to each of the areas are highlighted by example from field data collection. Insights regarding future guidance in these areas are presented based upon additional data collection subsequent to the original study.

  13. Case Study Methodology and Homelessness Research

    Directory of Open Access Journals (Sweden)

    Jill Pable

    2013-10-01

    Full Text Available This paper describes the potential suitability of case study methodology for inquiry with the homeless population. It references a research study that uses case study research method to build theory. This study's topic is the lived experience of destitute individuals who reside in homeless shelters, and explores the homeless shelter built environment's potential influence on resident satisfaction and recovery. Case study methodology may be appropriate because it explores real-life contextual issues that characterize homelessness and can also accommodate the wide range of homeless person demographics that make this group difficult to study in a generalized fashion. Further, case study method accommodates the need within research in this area to understand individualized treatments as a potential solution for homelessness.

  14. Case Study on Quality Education

    Science.gov (United States)

    Habib, Zahida

    2011-01-01

    Quality of Education, especially at Primary level, is an important issue to be discussed at the International Forum. This study highlights the quality of primary education through a comparison of the quality of Community Model Schools and Govt. Girls Primary Schools in Pakistan. Community Model Schools were established under Girls Primary…

  15. A Case Study of Engineering Ethics

    Science.gov (United States)

    Shimizu, Kazuo

    In Engineering Ethics Class at Shizuoka University, the Code of Ethics and Cases for Electrical Engineers by IEEJ Ethics committee is used to promote for high education effect to correspond large number of students (140students). In this paper, a case study in the class, and survey results for ethics value of students are presented. In addition, some comments for role playing act on the case of virtual experiences by students are described.

  16. Associative Visual Agnosia: A Case Study

    Directory of Open Access Journals (Sweden)

    A. Charnallet

    2008-01-01

    Full Text Available We report a case of massive associative visual agnosia. In the light of current theories of identification and semantic knowledge organization, a deficit involving both levels of structural description system and visual semantics must be assumed to explain the case. We suggest, in line with a previous case study [1], an alternative account in the framework of (non abstractive episodic models of memory [4].

  17. Marketing-Indonesia case study

    OpenAIRE

    Kurniawan, Iwan; Roshetko, James M.

    2007-01-01

    The purpose of research are (1) to identify the potential VAF species or products for Nanggung Farmers; (2) identify market channels & marketing problems; (3) enhances farmers' understanding of market mechanism; and (4) identify opportunities to improve the quantity & quality of VAF. The study was conducted on Sept-Oct 2006. Data and information are collected through Focus Group Discussion (FGD) in each village that attended both men and women. LTRA-5 (Agroforestry and Sustainable Vegetabl...

  18. Environmental contracting: a case study

    OpenAIRE

    Kubiak, Joseph C.

    1994-01-01

    Approved for public release, distribution unlimited The end of cold war levels of defense expenditures has promoted the reduction in the number of defense-related companies, creating potential monopolistic economic scenarios for defense procurement. This thesis studies one methodology to deal with these scenarios, based on the Baron-Myerson monopolist regulation mechanisms. The Baron-Myerson mechanism provides a tool to regulate monopolists when their costs are unknown or cannot be measure...

  19. Linguistic Overgeneralization: A Case Study

    Directory of Open Access Journals (Sweden)

    Wasan Nazar Al-Baldawi

    2011-08-01

    Full Text Available The current study described a single child’s language acquisition. The importance of this study resided in the circumstances and the environment in which the child lived. He came from a family in which the parents were from different countries and cultures; spoke different Arabic dialects and who lived in a country in which English is spoken. The child was in his critical period of language acquisition. He seemed to have established a unique way of communicating with people surrounding him to cope with all the linguistic varieties around him. The study showed that the child had semantic, syntactic and morphological overgeneralized structures. The data and results showed that overgeneralization and language acquisition were primarily an innate faculty of the human mind and that imitation did played a primary role in language acquisition.It showed, nevertheless, that imitation and behaviorist approaches could not fully account for language acquisition nor did the generative approach. The results went in favor of an Emergentist approach of language acquisition where both innateness and imitations were crucial constituents of children’s acquisition of linguistic forms.

  20. Mining the active proteome of Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Renier A. L. Van Der Hoorn

    2011-11-01

    Full Text Available Assigning functions to the >30.000 proteins encoded by the Arabidopsis genome is a challenging task of the Arabidopsis Functional Genomics Network. Although genome-wide technologies like proteomics and transcriptomics have generated a wealth of information that significantly accelerated gene annotation, protein activities are poorly predicted by transcript or protein levels as protein activities are post-translationally regulated. To directly display protein activities in Arabidopsis proteomes, we developed and applied Activity-based Protein Profiling (ABPP. ABPP is based on the use of small molecule probes that react with the catalytic residues of distinct protein classes in an activity-dependent manner. Labeled proteins are separated and detected from proteins gels and purified and identified by mass spectrometry. Using probes of six different chemotypes we have displayed of activities of 76 Arabidopsis proteins. These proteins represent over ten different protein classes that contain over 250 Arabidopsis proteins, including cysteine- serine- and metallo-proteases, lipases, acyltransferases, and the proteasome. We have developed methods for identification of in vivo labeled proteins using click-chemistry and for in vivo imaging with fluorescent probes. In vivo labeling has revealed novel protein activities and unexpected subcellular activities of the proteasome. Labeling of extracts displayed several differential activities e.g. of the proteasome during immune response and methylesterases during infection. These studies illustrate the power of ABPP to display the functional proteome and testify to a successful interdisciplinary collaboration involving chemical biology, organic chemistry and proteomics.

  1. Radiative damping: a case study

    CERN Document Server

    Spohn, Herbert

    2011-01-01

    We are interested in the motion of a classical charge coupled to the Maxwell self-field and subject to a uniform external magnetic field, B. This is a physically relevant, but difficult dynamical problem, to which contributions range over more than one hundred years. Specifically, we will study the Sommerfeld-Page approximation which assumes an extended charge distribution at small velocities. The memory equation is then linear and many details become available. We discuss how the friction equation arises in the limit of "small" B and contrast this result with the standard Taylor expansion resulting in a second order equation for the velocity of the charge.

  2. Brick handling: a case study.

    Science.gov (United States)

    Webb, R D; Handyside, J

    1982-09-01

    A small change in brick dimensions resulted in an increase in the perceived work-load of men loading and unloading pallets of bricks by hand. A laboratory study indicated that the change in brick dimensions required changes in grip pattern in order to unload bricks at the same rate, moving the same number at a time. These changed grip patterns resulted in increased upper body movement, increased chest-muscle activity and higher heart rates. These differences were reflected in higher subjective ratings of fatigue. PMID:15676442

  3. Ownership and Control Structures: A Case Study

    OpenAIRE

    Apostolov, Mico

    2015-01-01

    This is a study on separation of ownership and control in Southeast Europe, and in particular it is a case study of Macedonia. For structured analysis of this case study we use the World Bank Microdata Library, specifically the Enterprise Surveys which contains firm-level data of a representative sample of economies private sectors. What we are interested in are the ties of ownership and control and whether such linkages contribute to the development of domestic firms and the overall ec...

  4. Music in context : Four case studies

    NARCIS (Netherlands)

    Randwijck, R.J.C. van

    2008-01-01

    In his thesis entitled “Music in Context. Four Case Studies”, R.J.C. van Randwijck investigates the context in which music has been created. It is a search in Four Case Studies, approaching four pieces of music from the context in which they were written in order to understand their meaning. The inv

  5. Case studies of steel structure failures

    Directory of Open Access Journals (Sweden)

    P. Bernasovský

    2010-01-01

    Full Text Available The contribution deals with some case studies of steel structure failures, which happened in Slovakia a few years ago. Features of cracking are illustrated on real cases of breakdowns in the transmission gas pipelines, at the cement works and in the petrochemical indus-try. All failures were caused by an incorrect technical approach. Possible remedial measures are proposed.

  6. Abbreviated Case Studies in Organizational Communication

    Science.gov (United States)

    Wanguri, Deloris McGee

    2005-01-01

    The cases contained within organizational communication texts are generally two to three pages, often followed by questions. These case studies are certainly useful. They generally describe events in the present, provide some type of organizational context, include first-hand data, include a record of what people say and think, develop a…

  7. Mining Product Data Models: A Case Study

    OpenAIRE

    Cristina-Claudia DOLEAN

    2014-01-01

    This paper presents two case studies used to prove the validity of some data-flow mining algorithms. We proposed the data-flow mining algorithms because most part of mining algorithms focuses on the control-flow perspective. First case study uses event logs generated by an ERP system (Navision) after we set several trackers on the data elements needed in the process analyzed; while the second case study uses the event logs generated by YAWL system. We offered a general solution of data-flow m...

  8. Case study on printed matter

    DEFF Research Database (Denmark)

    Introduction Existing product Life Cycle Assessments (LCA’s) on offset printed matter all point at paper as the overall dominating contributor to the impacts from the life-cycle of this category of products. This dominating role of paper is primarily founded in the energy-related impact categories...... global warming, acidification and nutrification. The studies focus on energy consumption including the emissions and impact categories related to energy. The chemical-related impact categories comprising ecotoxicity and human toxicity are not included at all or only to a limited degree. In this paper we...... include these chemical-related impact categories by making use of some of the newest knowledge about emissions from the production at the printing industry combined with knowledge about the composition of the printing materials used during the production of offset printed matter. This paper is based...

  9. Case study in professionally-oriented training

    Directory of Open Access Journals (Sweden)

    Valitov Shamil M.

    2016-01-01

    Full Text Available Modern educational technologies are based on competence approach and focus on the future professional activity. Case study is one of the most significant technologies in modern higher education. The basic concepts used in the case study method are a “situation” and an “analysis”, as well as their derivative - “analysis of the situation”. The case study method of is one of the best tools for gaining experience, as it investigates practical situations that occur in managerial job. It combines theoretical knowledge with the analysis of the actual practical experience in accordance with a major. Doing case studies students read the description of the situation and offer divergent projects of managerial decisions that could be used by real managers dealing with the problem posed by the case study author. Answers to the questions posed in the case description are not given, as a rule, since the main purpose in the case analysis is to organize a discussion in the classroom or provoke speculations of those who do the self-study.

  10. Recombinant formate dehydrogenase from Arabidopsis thaliana: Preparation, crystal growth in microgravity, and preliminary X-ray diffraction study

    Energy Technology Data Exchange (ETDEWEB)

    Shabalin, I. G., E-mail: inna@ns.crys.ras.ru [Russian Academy of Sciences, Shubnikov Institute of Crystallography (Russian Federation); Serov, A. E.; Skirgello, O. E. [Moscow State University, Faculty of Chemistry (Russian Federation); Timofeev, V. I.; Samygina, V. R. [Russian Academy of Sciences, Shubnikov Institute of Crystallography (Russian Federation); Popov, V. O. [Russian Academy of Sciences, Bach Institute of Biochemistry (Russian Federation); Tishkov, V. I. [Moscow State University, Faculty of Chemistry (Russian Federation); Kuranova, I. P. [Russian Academy of Sciences, Shubnikov Institute of Crystallography (Russian Federation)

    2010-09-15

    Crystals of high-purity recombinant NAD{sup +}-dependent formate dehydrogenase from the higher plant Arabidopsis thaliana (AraFDH) were grown in microgravity in the Modul'-1 protein crystallization apparatus on the International Space Station. The space-grown crystals have larger sizes than those grown on Earth. X-ray diffraction data suitable for determining the three-dimensional structure were collected from the space-grown crystals to a resolution of 1.22 A using an X-ray synchrotron source. The crystals belong to sp. gr. P4{sub 3}2{sub 1}2; the unit-cell parameters are a = b = 107.865 A, c = 71.180 A, {alpha} = {beta} = {gamma} = 90 deg.

  11. Recombinant formate dehydrogenase from Arabidopsis thaliana: Preparation, crystal growth in microgravity, and preliminary X-ray diffraction study

    International Nuclear Information System (INIS)

    Crystals of high-purity recombinant NAD+-dependent formate dehydrogenase from the higher plant Arabidopsis thaliana (AraFDH) were grown in microgravity in the Modul'-1 protein crystallization apparatus on the International Space Station. The space-grown crystals have larger sizes than those grown on Earth. X-ray diffraction data suitable for determining the three-dimensional structure were collected from the space-grown crystals to a resolution of 1.22 A using an X-ray synchrotron source. The crystals belong to sp. gr. P43212; the unit-cell parameters are a = b = 107.865 A, c = 71.180 A, α = β = γ = 90 deg.

  12. Energy Audit: A Case Study

    Directory of Open Access Journals (Sweden)

    Sanjay Kumar

    2013-06-01

    Full Text Available This India is the Fifth largest producer of Electricalenergy in the world. Despite such achievements the gapbetween demand and supply of electrical energy is increasingevery year and power sector is highly capital – intensive. Thusthe deficit in installed capacity was nearly 10000MWper year.So the gap between demand and supply is continuouslyincreasing day by day. An energy audit is a study of a plant orfacility to determine how and where energy is used and toidentify methods for energy savings. The opportunities lie inthe use of existing renewable energy technologies, greaterefforts at energy efficiency and the dissemination of thesetechnologies and options. This thesis provides an overview of ageneral energy conservation measures (ECMs that can becommonly recommended for NIT Hamirpur. It should be notedthat the Energy auidut presented in this paper does not pretendto be exhaustive nor comprehensive. It provides merely toindicate some of the options that energy auditor can considerwhen performing an analysis of this institute. Energyconservation and exploration of new energy avenues are thewell accepted solution to fulfil the demand in future. The totalcost of energy plays a vital role in determining the product costof a commodity. Therefore the identification of potential energysavings and implementation for a given institutional facility isunimportant to ensure its competitive advantage over otherinstitute. This paper work presents such energy saving methodsin a methodological approach, experienced during a detailedenergy audit of NIT Hamirpur.

  13. Antiphospholipid syndrome: A case study

    Energy Technology Data Exchange (ETDEWEB)

    Davies, T. [Royal Adelaide Hospital, Adelaide, SA (Australia). Department of Nuclear Medicine

    1998-03-01

    Full text: A forty-two-year-old male presented to the Royal Adelaide Hospital with symptoms of increasing shortness of breath, swelling in both ankles, petechial rash and blood in his sputum. Initial investigations showed cardiomegaly, right ventricular hypertrophy, patchy lung infiltrates, a platelet count of 1500 and a clotting time of 60 seconds. A V/Q scan indicated a high probability of pulmonary embolism. Further investigations showed that the patient was positive for lupus anticoagulant and cardiolipin antibodies. A diagnosis of primary antiphospholipid syndrome was made. The patient``s high risk of strokes and hemorrhaging prompted investigation by a {sup 99}mTc-HMPAO brain scan. Further V/Q scans were performed to follow up the initial finding of multiple pulmonary embolism and a R-L shunt study was performed to investigate a left subclavian murmur. The patient was admitted for four weeks and began treatment which included cyclaphosphamide, corticosteroids and plasmaphoresis and was discharged when stable. Over the next six months he was re admitted three times for relapse of antiphospholipid syndrome. On his fourth admission he collapsed and died five hours after admission. Cause of death was due to cardiac arrhythmia secondary to severe right ventricular hypertrophy and dilation. The effects of antiphospholipid syndrome was believed to be responsible for this outcome.

  14. Blue light-dependent changes in loosely bound calcium in Arabidopsis mesophyll cells: an X-ray microanalysis study.

    Science.gov (United States)

    Łabuz, Justyna; Samardakiewicz, Sławomir; Hermanowicz, Paweł; Wyroba, Elżbieta; Pilarska, Maria; Gabryś, Halina

    2016-06-01

    Calcium is involved in the signal transduction pathway from phototropins, the blue light photoreceptor kinases which mediate chloroplast movements. The chloroplast accumulation response in low light is controlled by both phot1 and phot2, while only phot2 is involved in avoidance movement induced by strong light. Phototropins elevate cytosolic Ca(2+) after activation by blue light. In higher plants, both types of chloroplast responses depend on Ca(2+), and internal calcium stores seem to be crucial for these processes. Yet, the calcium signatures generated after the perception of blue light by phototropins are not well understood. To characterize the localization of calcium in Arabidopsis mesophyll cells, loosely bound (exchangeable) Ca(2+) was precipitated with potassium pyroantimonate and analyzed by transmission electron microscopy followed by energy-dispersive X-ray microanalysis. In dark-adapted wild-type Arabidopsis leaves, calcium precipitates were observed at the cell wall, where they formed spherical structures. After strong blue light irradiation, calcium at the apoplast prevailed, and bigger, multilayer precipitates were found. Spherical calcium precipitates were also detected at the tonoplast. After red light treatment as a control, the precipitates at the cell wall were smaller and less numerous. In the phot2 and phot1phot2 mutants, calcium patterns were different from those of wild-type plants. In both mutants, no elevation of calcium after blue light treatment was observed at the cell periphery (including the cell wall and a fragment of cytoplasm). This result confirms the involvement of phototropin2 in the regulation of Ca(2+) homeostasis in mesophyll cells.

  15. Towards More Case Study Research in Entrepreneurship

    Directory of Open Access Journals (Sweden)

    Tom Duxbury

    2012-03-01

    Full Text Available Entrepreneurship as an emerging discipline has made good strides, but according to some, has fallen short of bringing its theory and literature up to the standards of others in the management sciences. Rich with the descriptive detail needed for insightful theory building in entrepreneurship, scholars have called for more case study research, particularly those incorporating non-retrospective and longitudinal observations. At the same time however, it has become rare to find such research published in A-level journals dedicated to entrepreneurship. A survey presented here of major entrepreneurship journals over the past six years revealed a publication rate of only 3% using the case study method. This presents a major impediment for developing fresh research in this field based upon the study of real cases. The author explores how the case study method has been applied to entrepreneurship research and provides recommendations for improved publication rates.

  16. Educational Potential of Case-Study Technology

    OpenAIRE

    Fedorinova, Zoya Vladimirovna; Vorobyeva, Viktoriya Vladimirovna; Malyanova, Marina

    2015-01-01

    This article presents the results of phenomenological and typological analysis of case-study technology educational potential. The definition “educational potential of case-study technology” is given, the main characteristics of which are changed in communication and collaborative activity quality, appearance of educational initiatives, change of participants’ position in learning process, formation of “collective subject” in collaborative activity, increase of learning (subject) results. Dep...

  17. TOP-10 DATA MINING CASE STUDIES

    OpenAIRE

    GABOR MELLI; XINDONG WU; PAUL BEINAT; FRANCESCO BONCHI; LONGBING CAO; RONG DUAN; CHRISTOS FALOUTSOS; RAYID GHANI; BRENDAN KITTS; BART GOETHALS; GEOFF MCLACHLAN; JIAN PEI; ASHOK SRIVASTAVA; OSMAR ZAÏANE

    2012-01-01

    We report on the panel discussion held at the ICDM'10 conference on the top 10 data mining case studies in order to provide a snapshot of where and how data mining techniques have made significant real-world impact. The tasks covered by 10 case studies range from the detection of anomalies such as cancer, fraud, and system failures to the optimization of organizational operations, and include the automated extraction of information from unstructured sources. From the 10 cases we find that sup...

  18. Multidimensional solid-state NMR studies of the structure and dynamics of pectic polysaccharides in uniformly 13C-labeled Arabidopsis primary cell walls

    Energy Technology Data Exchange (ETDEWEB)

    Dick-Perez, Marilu; Wang, Tuo; Salazar, Andre; Zabotina, Olga A.; Hong, Mei

    2012-07-08

    Plant cell wall (CW) polysaccharides are responsible for the mechanical strength and growth of plant cells; however, the high-resolution structure and dynamics of the CW polysaccharides are still poorly understood because of the insoluble nature of these molecules. Here, we use 2D and 3D magic-angle-spinning (MAS) solid-state NMR (SSNMR) to investigate the structural role of pectins in the plant CW. Intact and partially depectinated primary CWs of Arabidopsis thaliana were uniformly labeled with 13C and their NMR spectra were compared. Recent 13C resonance assignment of the major polysaccharides in Arabidopsis thaliana CWs allowed us to determine the effects of depectination on the intermolecular packing and dynamics of the remaining wall polysaccharides. 2D and 3D correlation spectra show the suppression of pectin signals, confirming partial pectin removal by chelating agents and sodium carbonate. Importantly, higher cross peaks are observed in 2D and 3D 13C spectra of the depectinated CW, suggesting higher rigidity and denser packing of the remaining wall polysaccharides compared with the intact CW. 13C spin–lattice relaxation times and 1H rotating-frame spin–lattice relaxation times indicate that the polysaccharides are more rigid on both the nanosecond and microsecond timescales in the depectinated CW. Taken together, these results indicate that pectic polysaccharides are highly dynamic and endow the polysaccharide network of the primary CW with mobility and flexibility, which may be important for pectin functions. This study demonstrates the capability of multidimensional SSNMR to determine the intermolecular interactions and dynamic structures of complex plant materials under near-native conditions. Copyright © 2012 John Wiley & Sons, Ltd.

  19. Predicting Students Drop Out: A Case Study

    Science.gov (United States)

    Dekker, Gerben W.; Pechenizkiy, Mykola; Vleeshouwers, Jan M.

    2009-01-01

    The monitoring and support of university freshmen is considered very important at many educational institutions. In this paper we describe the results of the educational data mining case study aimed at predicting the Electrical Engineering (EE) students drop out after the first semester of their studies or even before they enter the study program…

  20. Case Study Report about Gender Impact Assessment

    DEFF Research Database (Denmark)

    Faber, Stine Thidemann; Agustin, Lise Rolandsen

    2013-01-01

    The aim of this national case study report is to take a closer look at the use of Gender Impact Assessments in Denmark in order to describe the Danish implementation of this specific Gender Mainstreaming method. By way of analyzing two selected cases (two law proposals put forward by The Danish...... Ministry of Employment and the Danish Ministry of Transport, respectively) the aim is to assess the transformative potential of GIA as it is performed in Denmark....

  1. Gigantic Suprapubic Lymphedema: A Case Study.

    Science.gov (United States)

    Tanhaeivash, Roozbeh; Franiel, Tobias; Grimm, Marc-Oliver; Horstmann, Marcus

    2016-08-01

    We present the first case study of idiopathic gigantic suprapubic lymphedema and buried penis treated with puboscrotal reconstruction in a patient with initial extreme obesity after an extensive weight reduction (120 kg). Massive localized lymphedema of the suprapubic region should be differentiated from the scrotal type. Severe lymphedema could not resolve on its own and weight reduction does not seem to be helpful in such cases. PMID:27574599

  2. Case Study Research Methodology in Nursing Research.

    Science.gov (United States)

    Cope, Diane G

    2015-11-01

    Through data collection methods using a holistic approach that focuses on variables in a natural setting, qualitative research methods seek to understand participants' perceptions and interpretations. Common qualitative research methods include ethnography, phenomenology, grounded theory, and historic research. Another type of methodology that has a similar qualitative approach is case study research, which seeks to understand a phenomenon or case from multiple perspectives within a given real-world context.

  3. Gigantic Suprapubic Lymphedema: A Case Study

    Science.gov (United States)

    Tanhaeivash, Roozbeh; Franiel, Tobias; Grimm, Marc-Oliver

    2016-01-01

    We present the first case study of idiopathic gigantic suprapubic lymphedema and buried penis treated with puboscrotal reconstruction in a patient with initial extreme obesity after an extensive weight reduction (120 kg). Massive localized lymphedema of the suprapubic region should be differentiated from the scrotal type. Severe lymphedema could not resolve on its own and weight reduction does not seem to be helpful in such cases. PMID:27574599

  4. Tape-Arabidopsis Sandwich - a simpler Arabidopsis protoplast isolation method

    Directory of Open Access Journals (Sweden)

    Lee Shu-Hong

    2009-11-01

    Full Text Available Abstract Background Protoplasts isolated from leaves are useful materials in plant research. One application, the transient expression of recombinant genes using Arabidopsis mesophyll protoplasts (TEAMP, is currently commonly used for studies of subcellular protein localization, promoter activity, and in vivo protein-protein interactions. This method requires cutting leaves into very thin slivers to collect mesophyll cell protoplasts, a procedure that often causes cell damage, may yield only a few good protoplasts, and is time consuming. In addition, this protoplast isolation method normally requires a large number of leaves derived from plants grown specifically under low-light conditions, which may be a concern when material availability is limited such as with mutant plants, or in large scale experiments. Results In this report, we present a new procedure that we call the Tape-Arabidopsis Sandwich. This is a simple and fast mesophyll protoplast isolation method. Two kinds of tape (Time tape adhered to the upper epidermis and 3 M Magic tape to the lower epidermis are used to make a "Tape-Arabidopsis Sandwich". The Time tape supports the top side of the leaf during manipulation, while tearing off the 3 M Magic tape allows easy removal of the lower epidermal layer and exposes mesophyll cells to cell wall digesting enzymes when the leaf is later incubated in an enzyme solution. The protoplasts released into solution are collected and washed for further use. For TEAMP, plasmids carrying a gene expression cassette for a fluorescent protein can be successfully delivered into protoplasts isolated from mature leaves grown under optimal conditions. Alternatively, these protoplasts may be used for bimolecular fluorescence complementation (BiFC to investigate protein-protein interactions in vivo, or for Western blot analysis. A significant advantage of this protocol over the current method is that it allows the generation of protoplasts in less than 1 hr

  5. Clean Cities Case Study: Barwood Cab Fleet Study Summary

    International Nuclear Information System (INIS)

    Barwood Cab Fleet Study Summary is the second in a new series called''Alternative Fuel Information Case Studies,'' designed to present real-world experiences with alternative fuels to fleet managers and other industry stakeholders

  6. Social Studies Project Evaluation: Case Study and Recommendations.

    Science.gov (United States)

    Napier, John

    1982-01-01

    Describes the development and application of a model for social studies program evaluations. A case study showing how the model's three-step process was used to evaluate the Improving Citizenship Education Project in Fulton County, Georgia is included. (AM)

  7. Connecting Reading and Writing: A Case Study

    Science.gov (United States)

    Li, Zhanfang

    2015-01-01

    Connecting reading and writing, proposed by many scholars, is realized in this case study. The 30 participants in this study are the English majors of the third year in one School of Foreign Languages in Beijing. They are encouraged to write journals every week, based on the source text materials in their Intensive Reading class, with the final…

  8. Collaborative Assessment: Middle School Case Study

    Science.gov (United States)

    Parkison, Paul T.

    2014-01-01

    Utilizing a participant observer research model, a case study of the efficacy of a collaborative assessment methodology within a middle school social studies class was conducted. A review of existing research revealed that students' perceptions of assessment, evaluation, and accountability influence their intrinsic motivation to learn. A…

  9. A Multiple Case Study of Innovation

    Science.gov (United States)

    Zheng, Wei; Khoury, Anne E.

    2008-01-01

    This study aims to explore how leadership and contextual factors influence innovation in R&D teams in national laboratories, using the approach of multiple case studies. This paper provides some preliminary findings from two highly innovative teams residing in two national laboratories in the US. The preliminary results suggested several common…

  10. Measuring marketing performance - A case study

    OpenAIRE

    Laakso, Vesa-Pekka

    2011-01-01

    PURPOSE OF THE STUDY The purpose of this study is to develop a marketing dashboard for a Finnish company that operates in the financial industry. The identification of suitable metrics for assessing marketing performance is considered central. This study proposes a new construct (a dashboard) that aims to providing management relevant information on marketing performance from decision-making perspective. METHODOLOGY AND DATA The methodology is a constructive case study. In the...

  11. Kinome profiling of Arabidopsis using arrays of kinase consensus substrates

    Directory of Open Access Journals (Sweden)

    Pieterse Corné MJ

    2007-02-01

    Full Text Available Abstract Background Kinome profiling aims at the parallel analysis of kinase activities in a cell. Novel developed arrays containing consensus substrates for kinases are used to assess those kinase activities. The arrays described in this paper were already used to determine kinase activities in mammalian systems, but since substrates from many organisms are present we decided to test these arrays for the determination of kinase activities in the model plant species Arabidopsis thaliana. Results Kinome profiling using Arabidopsis cell extracts resulted in the labelling of many consensus peptides by kinases from the plant, indicating the usefulness of this kinome profiling tool for plants. Method development showed that fresh and frozen plant material could be used to make cell lysates containing active kinases. Dilution of the plant extract increased the signal to noise ratio and non-radioactive ATP enhances full development of spot intensities. Upon infection of Arabidopsis with an avirulent strain of the bacterial pathogen Pseudomonas syringae pv. tomato, we could detect differential kinase activities by measuring phosphorylation of consensus peptides. Conclusion We show that kinome profiling on arrays with consensus substrates can be used to monitor kinase activities in plants. In a case study we show that upon infection with avirulent P. syringae differential kinase activities can be found. The PepChip can for example be used to purify (unknown kinases that play a role in P. syringae infection. This paper shows that kinome profiling using arrays of consensus peptides is a valuable new tool to study signal-transduction in plants. It complements the available methods for genomics and proteomics research.

  12. The study on space-flight induced DNA damage in Arabidopsis thaliana and the protective effect of hydrogen

    Science.gov (United States)

    Sun, Qiao; Liu, Min; Zhao, Hui

    2016-07-01

    Ionizing radiation (IR) is a known mutagen responsible for causing DNA strand breaks in all living organisms. Strand breaks thus created can be repaired by different mechanisms, including homologous recombination (HR), one of the key mechanisms maintaining genome stability. Here, we used previously generated Arabidopsis thaliana, transgenic for homologous recombination reporter system, in which homologous recombination frequency(HRF) was used as mutagenic end points. Based on the system, effect of DNA damage by space-flight during the Shenzhou-9 mission was investigated and the results showed that 13 days space-flight exposure of seedlings induced a significant increase in HRF compared with its ground-base three-dimensional clinostat controls and ground 1g controls. We also observed three-dimensional clinostat induced a significant increase in HRF compared with ground 1g controls. Molecular hydrogen (H2) has antioxidant activities by selectively reducing hydroxylradical ( •OH) and peroxynitrite(ONOO-), so we investigated the effect of hydrogen on IR-induced HRF. Treatment with hydrogen-rich water dramatically reduced the HR frequency induced by exposure of seedlings to 0 to 80 Gy 60Co radiation , suggesting that hydrogen represents a potentially novel preventative strategy for radiation-induced DNA damage in plants.

  13. Mining Product Data Models: A Case Study

    Directory of Open Access Journals (Sweden)

    Cristina-Claudia DOLEAN

    2014-01-01

    Full Text Available This paper presents two case studies used to prove the validity of some data-flow mining algorithms. We proposed the data-flow mining algorithms because most part of mining algorithms focuses on the control-flow perspective. First case study uses event logs generated by an ERP system (Navision after we set several trackers on the data elements needed in the process analyzed; while the second case study uses the event logs generated by YAWL system. We offered a general solution of data-flow model extraction from different data sources. In order to apply the data-flow mining algorithms the event logs must comply a certain format (using InputOutput extension. But to respect this format, a set of conversion tools is needed. We depicted the conversion tools used and how we got the data-flow models. Moreover, the data-flow model is compared to the control-flow model.

  14. Integrating Ethics into Case Study Assignments

    Directory of Open Access Journals (Sweden)

    Pamela A. Marshall

    2014-08-01

    Full Text Available I teach an upper-level writing course, Genes, Race, Gender, and Society, designed for Life Science majors, in which I utilize a case study to expose students to ethical ways of thinking.  Students first work through the topical case study and then are challenged to rethink their responses through the lenses of ethics, taking into account different ethical frameworks.  Students then develop their own case study, integrating ethical components.  I want to expose my students to this way of thinking because I see technology being driven by the Jurassic Park phenomenon, "Your scientists were so preoccupied with whether or not they could, they didn't stop to think if they should." and want future physicians grounded in a sense of how their actions relate to the greater good.

  15. Cryostat design case studies, principles and engineering

    CERN Document Server

    2016-01-01

    This book enables the reader to learn the fundamental and applied aspects of practical cryostat design by examining previous design choices and resulting cryostat performance. Through a series of extended case studies the book presents an overview of existing cryostat design covering a wide range of cryostat types and applications, including the magnet cryostats that comprise the majority of the Large Hadron Collider at CERN, space-borne cryostats containing sensors operating below 1 K, and large cryogenic liquid storage vessels. It starts with an introductory section on the principles of cryostat design including practical data and equations. This section is followed by a series of case studies on existing cryostats, describing the specific requirements of the cryostat, the challenges involved and the design choices made along with the resulting performance of the cryostat. The cryostat examples used in the studies are chosen to cover a broad range of cryostat applications and the authors of each case are ...

  16. Shuttle Case Study Collection Website Development

    Science.gov (United States)

    Ransom, Khadijah S.; Johnson, Grace K.

    2012-01-01

    As a continuation from summer 2012, the Shuttle Case Study Collection has been developed using lessons learned documented by NASA engineers, analysts, and contractors. Decades of information related to processing and launching the Space Shuttle is gathered into a single database to provide educators with an alternative means to teach real-world engineering processes. The goal is to provide additional engineering materials that enhance critical thinking, decision making, and problem solving skills. During this second phase of the project, the Shuttle Case Study Collection website was developed. Extensive HTML coding to link downloadable documents, videos, and images was required, as was training to learn NASA's Content Management System (CMS) for website design. As the final stage of the collection development, the website is designed to allow for distribution of information to the public as well as for case study report submissions from other educators online.

  17. Induction and characterization of Arabidopsis mutants by Ion beam

    International Nuclear Information System (INIS)

    This study was conducted to search the proper conditions and times for irradiating proton beam to seeds generally used for induction of mutant. Arabidopsis as model plants has good characters that is a short generation time, producing a lot of seeds, sequenced genome, developed maker. This points were the best materials for plant breeding for this study. The data of inducing mutants of Arabidopsis is used to be applicate to crops have more longer generation that is the final goals of this study. The goals of this project were to inducing and characterizing arabidopsis mutants by the proton ion beam and γ-ray. As well as, the purpose of this study was securing more than 10 lines of arabidopsis mutants in this project and also to know the changed DNA structure of the mutants using the basic data for applying to the more study

  18. SYNONYMS IN ACTION: A CASE STUDY

    Directory of Open Access Journals (Sweden)

    Rebecca Clift

    2003-05-01

    Full Text Available This paper discusses what the methods of conversation analysis (CA might have to offer the study of linguistic synonymy. It takes as a case study two items commonly held to be synonyms -'actually' and 'in fact'- and shows considerable differences between the two in their interactional implementation: they are implicated in the prosecution of differing courses of action. Such cases argue that it is analytically more profitable to consider what a lexical item does in the context of talk than what it means.

  19. Repurposing legacy data innovative case studies

    CERN Document Server

    Berman, Jules J

    2015-01-01

    Repurposing Legacy Data: Innovative Case Studies takes a look at how data scientists have re-purposed legacy data, whether their own, or legacy data that has been donated to the public domain. Most of the data stored worldwide is legacy data-data created some time in the past, for a particular purpose, and left in obsolete formats. As with keepsakes in an attic, we retain this information thinking it may have value in the future, though we have no current use for it. The case studies in this book, from such diverse fields as cosmology, quantum physics, high-energy physics, microbiology,

  20. Corporate Social Responsibility : A Case Study

    OpenAIRE

    Björkqvist, Kira

    2012-01-01

    The importance of taking responsibility for the common environmental and social welfare has become of essence in the business world of the 21st century. This thesis provides the reader with knowledge on corporate social responsibility (CSR) and shows the reader a comparative study on how CSR is reported on in three case study companies chosen for this thesis. This thesis is a descriptive study that uses the research method of content analysis to determine the commonalities and differences...

  1. Collagenous ileitis: a study of 13 cases.

    Science.gov (United States)

    O'Brien, Blake Hugh; McClymont, Kelly; Brown, Ian

    2011-08-01

    Collagenous ileitis (CI), characterized by subepithelial collagen deposition in the terminal ileum, is an uncommon condition. The few cases reported to date have been associated with collagenous colitis (CC) or lymphocytic colitis. Thirteen cases of CI retrieved over a 9-year period were retrospectively studied. There were 7 female and 6 male patients, with an age range of 39 to 72 years (mean, 64 y). Two groups were identified: (1) CI associated with collagenous or lymphocytic disease elsewhere in the gastrointestinal tract and (2) CI as an isolated process. Diarrhea was the presenting symptom in 11 cases. Most patients had no regular medication use. Subepithelial collagen thickness ranged from 15 to 100 μm (mean, 32 μm) and involved 5% to 80% of the subepithelial region of the submitted biopsies. Six cases had >25 intraepithelial lymphocytes (IELs)/100 epithelial cells, and villous blunting was observed in 11 cases. Chronic inflammation of the lamina propria was present in 9 cases, and focal neutrophil infiltration was identified in 3 cases. In biopsies taken from other sites, 7 of 13 colonic biopsies showed CC, 4 of 9 gastric biopsies showed collagenous gastritis, and 2 of 10 duodenal biopsies were abnormal with collagenous sprue (n=1) and partial villous atrophy and increased IELs (n=1) (both celiac disease related). Resolution of the subepithelial collagen deposition was found in the 1 case in which follow-up of terminal ileal biopsies were taken. There was partial or complete resolution of symptoms in 6 of 9 patients for whom follow-up information was available. PMID:21716082

  2. Microbial study of meningitis and encephalitis cases.

    Science.gov (United States)

    Selim, Heba S; El-Barrawy, Mohamed A; Rakha, Magda E; Yingst, Samuel L; Baskharoun, Magda F

    2007-01-01

    Meningitis and/or encephalitis can pose a serious public health problem especially during outbreaks. A rapid and accurate diagnosis is important for effective earlier treatment. This study aimed to identify the possible microbial causes of meningitis and/or encephalitis cases. CSF and serum samples were collected from 322 patients who had signs and symptoms suggestive of meningitis and/or encephalitis. Out of 250 cases with confirmed clinical diagnosis, 83 (33.2%) were definitely diagnosed as bacterial meningitis and/or encephalitis cases (by using CSF culture, biochemical tests, latex agglutination test, and CSF stain), 17 (6.8%) were definitely diagnosed as having viral causes ( by viral isolation on tissue culture, PCR and ELISA), and one (0.4%) was diagnosed as fungal meningitis case (by India ink stain, culture, and biochemical tests). Also, there was one encephalitis case with positive serum ELISA IgM antibodies against Sandfly scilian virus. N. meningitidis, S. pneumonia and M. tuberculosis were the most frequently detected bacterial agents, while Enteroviruses, herpes simplex viruses and varicella zoster viruses were the most common viral agents encountered. Further studies are needed to assess the role of different microbial agents in CNS infections and their effective methods of diagnosis.

  3. WMOST v2 Case Study: Monponsett Ponds

    Science.gov (United States)

    This webinar presents an overview of the preliminary results of a case study application of EPA's Watershed Management Optimization Support Tool v2 (WMOST) for stakeholders in the Monponsett Ponds Watershed Workgroup. Monponsett Ponds is a large water system consisting of two ba...

  4. Recurrent perinatal loss: a case study.

    Science.gov (United States)

    Kavanaugh, K; Robertson, P A

    1999-01-01

    To date, investigators have not demonstrated a clear relationship between a parent's history of prior perinatal losses and intensity of grief response following a subsequent perinatal loss. Examining this relationship for low-income, African-American parents is important because they are a vulnerable population due to the high incidence of perinatal mortality in Blacks and their other life stressors that can impact on grief response and caring needs. The purpose of this case study was to examine the impact of recurrent perinatal loss on a low-income African-American parent. The research design for this study was case report, using interview data collected from a mother who had recently experienced her fourth perinatal loss, which occurred at twenty-five weeks of gestation. Transcripts from two open-ended interviews were analyzed. The theoretical framework used to guide analysis of this case study was Lazarus and Folkman's stress and coping theory. Results demonstrated that the prior perinatal losses did not appear as critical components of the way the mother responded to her most recent loss. Instead, perception of the care she received from healthcare providers and how that care related to her experiences with her one living child who was born at the same gestational age was an important determinant in how she responded to her loss. The results of this case study demonstrate the importance assessing a person's perception of their experience and those factors which contribute to the way they respond.

  5. Teaching the Holocaust through Case Study

    Science.gov (United States)

    Misco, Thomas

    2009-01-01

    This article responds to the curricular challenges teachers face with Holocaust education, including cursory treatments and a lack of focus on individual experiences. First, the author argues for a case-study approach to help students reengage concrete and complex features of the Holocaust as a point of departure for subsequent inquiry. In…

  6. Lifelong Learning in SMEs: A Case Study.

    Science.gov (United States)

    Holden, Rick; Smith, Vikki; Devins, Dave

    2002-01-01

    Learning centers using information-communications technologies were established in three British industrial estates. A case study of one organization shows the center contributed to lifelong learning and enhanced information technology training and employee confidence. Transfer of training and productivity improvements were not as clear. (Contains…

  7. It's Not Funny: A Case Study

    Science.gov (United States)

    Méndez-Morse, Sylvia

    2015-01-01

    This case study may be used with personnel supervision, school law, and other school leadership courses. It describes the behavior and actions of one teacher toward another. Student discussions can focus on supervision, workplace mobbing, workplace bullying, as well as sexual harassment. Students should focus on a school leader's role in such…

  8. Physical Science Connected Classrooms: Case Studies

    Science.gov (United States)

    Irving, Karen; Sanalan, Vehbi; Shirley, Melissa

    2009-01-01

    Case-study descriptions of secondary and middle school classrooms in diverse contexts provide examples of how teachers implement connected classroom technology to facilitate formative assessment in science instruction. Connected classroom technology refers to a networked system of handheld devices designed for classroom use. Teachers were…

  9. The Verbal Noncommunicator: A Case Study.

    Science.gov (United States)

    Fujiki, Martin; Brinton, Bonnie

    1991-01-01

    This article presents a case study of a nine-year-old male with language impairment and specific pragmatic disabilities. His interactions with an adult, a language age-matched peer, and a chronological age-matched peer were observed and analyzed to determine conversational responsiveness and assertiveness. Findings support Fey's (1986) verbal…

  10. Acoustical case studies of three green buildings

    Science.gov (United States)

    Siebein, Gary; Lilkendey, Robert; Skorski, Stephen

    2005-04-01

    Case studies of 3 green buildings with LEED certifications that required extensive acoustical retrofit work to become satisfactory work environments for their intended user groups will be used to define areas where green building design concepts and acoustical design concepts require reconciliation. Case study 1 is an office and conference center for a city environmental education agency. Large open spaces intended to collect daylight through clerestory windows provided large, reverberant volumes with few acoustic finishes that rendered them unsuitable as open office space and a conference room/auditorium. Case Study 2 describes one of the first gold LEED buildings in the southeast whose primary design concepts were so narrowly focused on thermal and lighting issues that they often worked directly against basic acoustical requirements resulting in sound levels of NC 50-55 in classrooms and faculty offices, crosstalk between classrooms and poor room acoustics. Case study 3 is an environmental education and conference center with open public areas, very high ceilings, and all reflective surfaces made from wood and other environmentally friendly materials that result in excessive loudness when the building is used by the numbers of people which it was intended to serve.

  11. Performance-Related Pay: A Case Study.

    Science.gov (United States)

    Swabe, A. I. R.

    1989-01-01

    Discusses performance-related pay and why the system was introduced, how it was negotiated, and how it has operated. The case study illustrated is in a British financial services company where the system was negotiated in 1986 and began in 1987. (JOW)

  12. Acquaintance Rape: A Case Study Approach.

    Science.gov (United States)

    Marinelli, Rosalie D.

    1994-01-01

    Describes a case study approach to acquaintance rape used in a Personal Health and Lifestyles course at the University of Nevada in Reno that allows students to discuss the characters in a scenario, an instructional process seen as less threatening than describing personal experiences. (MDM)

  13. A Case Study on Distributed Antenna Systems

    DEFF Research Database (Denmark)

    Sørensen, Troels Bundgaard

    2007-01-01

    to changing interference and traffic conditions are less common, despite their potential for increased capacity in comparison with traditional (pico)cellular based concepts. This chapter explores a case study of one indoor environment where the site-specific propagation characteristics are taken into account...

  14. Case Studies on Globalization and Money Laundering

    OpenAIRE

    Eckhard Freyer

    2008-01-01

    Financial globalization has greatly improved the efficiency of capital transfers around the world, with the cost of facilitating criminal money laundering activities. Based on case studies on conditions for money laundering in the process of globalization and transformation in Europe, are discussed the challenges that a “global financial village” must confront.

  15. A CASE STUDY OF ENVIRONMENTAL DATA MANAGEMENT

    Science.gov (United States)

    In order to support our ongoing research in watershed ecology and global climate change, we gather and analyze environmental data from several government agencies. This case study demonstrates a researcher’s approach to accessing, organizing, and using intersectoral data. T...

  16. Comparative Environmental Threat Analysis: Three Case Studies.

    Science.gov (United States)

    Latour, J. B.; Reiling, R.

    1994-01-01

    Reviews how carrying capacity for different environmental problems is operationalized. Discusses whether it is possible to compare threats, using the exceeding of carrying capacity as a yardstick. Points out problems in comparative threat analysis using three case studies: threats to European groundwater resources, threats to ecosystems in Europe,…

  17. Learning Machine Learning: A Case Study

    Science.gov (United States)

    Lavesson, N.

    2010-01-01

    This correspondence reports on a case study conducted in the Master's-level Machine Learning (ML) course at Blekinge Institute of Technology, Sweden. The students participated in a self-assessment test and a diagnostic test of prerequisite subjects, and their results on these tests are correlated with their achievement of the course's learning…

  18. Firefighter Workplace Learning: An Exploratory Case Study

    Science.gov (United States)

    Tracey, Edward A.

    2014-01-01

    Despite there being a significant amount of research investigating workplace learning, research exploring firefighter workplace learning is almost nonexistent. The purpose of this qualitative multi-case study was to explore how firefighters conceptualize, report, and practice workplace learning. The researcher also investigated how firefighters…

  19. Climate wise case study compendium: Report 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-02-01

    This case study compendium is one of several Climate Wise tools available to help interested companies identify cost-effective options. Climate Wise, a private-public partnership program, is a key Federal initiative to return greenhouse gas emissions to 1990 levels by 2000.

  20. Fraternization in Accounting Firms: A Case Study

    Science.gov (United States)

    Heinze, Tim; Kizirian, Tim; Leese, Wallace

    2004-01-01

    This case study sheds light on how to avoid risks caused by manager-subordinate dating relationships (fraternization) such as employee misunderstandings, retaliation charges, favoritism complaints, wrongful termination lawsuits, and sexual harassment lawsuits, as well as associated ethical risks. Risk avoidance can be accomplished through a better…

  1. ESL and Digital Video Integration: Case Studies

    Science.gov (United States)

    Li, J., Ed.; Gromik, N., Ed.; Edwards, N., Ed.

    2013-01-01

    It should come as no surprise that digital video technology is of particular interest to English language learners; students are drawn to its visual appeal and vibrant creative potential. The seven original case studies in this book demonstrate how video can be an effective and powerful tool to create fluid, fun, interactive, and collaborative…

  2. Protease gene families in Populus and Arabidopsis

    Directory of Open Access Journals (Sweden)

    Jansson Stefan

    2006-12-01

    Full Text Available Abstract Background Proteases play key roles in plants, maintaining strict protein quality control and degrading specific sets of proteins in response to diverse environmental and developmental stimuli. Similarities and differences between the proteases expressed in different species may give valuable insights into their physiological roles and evolution. Results We have performed a comparative analysis of protease genes in the two sequenced dicot genomes, Arabidopsis thaliana and Populus trichocarpa by using genes coding for proteases in the MEROPS database 1 for Arabidopsis to identify homologous sequences in Populus. A multigene-based phylogenetic analysis was performed. Most protease families were found to be larger in Populus than in Arabidopsis, reflecting recent genome duplication. Detailed studies on e.g. the DegP, Clp, FtsH, Lon, rhomboid and papain-Like protease families showed the pattern of gene family expansion and gene loss was complex. We finally show that different Populus tissues express unique suites of protease genes and that the mRNA levels of different classes of proteases change along a developmental gradient. Conclusion Recent gene family expansion and contractions have made the Arabidopsis and Populus complements of proteases different and this, together with expression patterns, gives indications about the roles of the individual gene products or groups of proteases.

  3. Empathy Development Through Case Study and Simulation.

    Science.gov (United States)

    Mennenga, Heidi A; Bassett, Susan; Pasquariello, Libby

    2016-01-01

    Because empathy is integral to the nurse-patient relationship, nurse educators are challenged to explore teaching strategies that may aid in the development of empathy among students. The purpose of this study was to determine whether consistent exposure to a single patient through case study and simulation had an impact on empathy levels in senior-level baccalaureate nursing students. Results provide interesting conclusions for faculty members and offer a basis for ongoing discussion.

  4. Mobile Technologies Adoption: An Exploratory Case Study

    Institute of Scientific and Technical Information of China (English)

    CHU Yan; HUANG Lihua

    2008-01-01

    Based on the theory of task-technology fit and literature review of mobile technology acceptance, a research model is presented based on the features of mobile technologies and the actual usage of mobile applications in business environments, which identifies the characteristics of mobile applications and fitting tasks. An exploratory case is studied to understand how ABC Company, Hong Kong, utilizes mobile selling applications in their sales management process. This study gives some managerial suggestions for enterprises to successfully use mobile applications.

  5. Case studies on selected natural food antioxidants

    OpenAIRE

    Herrero, Miguel; Mendiola, J. A.; Cifuentes, Alejandro; Ibáñez, Elena

    2013-01-01

    In this chapter, a broad description of several case studies related to common antioxidants found in food-related products is presented. In this regard, special attention is put on the novel advanced environmentally-friendly extraction methods nowadays employed to extract and purify those potent antioxidants from natural matrices. A brief description of these extraction processes is provided together with some of the instrumentation needed. Besides, the studies carried out so f...

  6. MARKET INTEGRATION: CASE STUDIES OF STRUCTURAL CHANGE

    OpenAIRE

    Franken, Jason R.V.; Parcell, Joseph L.

    2003-01-01

    The grain/oilseed industry is undergoing considerable structural change in the form of mergers and the addition of new processing facilities to add value beyond commodity grade. The rapid structural changes in this industry call into question the relevance of previous research conducted in these areas. Focusing on two structural change events in northeast Missouri as case studies provides an incisive glimpse at the larger impact of structural change on the grain/oilseed industry. This study a...

  7. Success against the odds: A case study

    OpenAIRE

    Ahmadbayli, Aydan

    2015-01-01

    The purpose of this dissertation is to examine the leadership behaviours and practices necessary for school ‘turnaround’. The research was conducted by taking a multi perspective approach within a qualitative research study to explore the case of a UK based school facing ‘special measures’ and in disadvantaged circumstances. Research methods employed include a documentary study and semi-structured interviews with six members of staff. The results indicated that effective turnaround leaders em...

  8. Can We Generalize from Case Studies?

    OpenAIRE

    Paul F. Steinberg

    2015-01-01

    This article considers the role of generalization in comparative case studies, using as exemplars the contributions to this special issue on climate change politics. As a research practice, generalization is a logical argument for extending one’s claims beyond the data, positing a connection between events that were studied and those that were not. No methodological tradition is exempt from the requirement to demonstrate a compelling logic of generalization. The article presents a taxonomy of...

  9. CAT: A CASE STUDY OF GRE

    Institute of Scientific and Technical Information of China (English)

    WangZe; ChenJiliang

    2004-01-01

    The Computer Adaptive Testing (CAT) has developedsuccessfully with its adoption by testing agencies. The authors ofthis paper point out the advantages and disadvantages of CATsand then take GRE as a case study to probe into the scoringalgorithm in CAT. By analyzing some typical score reports ofcomputer-adaptive GRE General Test, they study some majorfactors affecting the final score such as the percentage ofcorrectness and difficulty levels.

  10. Using case studies in management education: the student perspective.

    OpenAIRE

    BRENNAN, ROSS; Ahmad, S. Jaseem

    2005-01-01

    Case studies are widely used in management education. Most of the literature discussing the case study method has reflected the perspective of the teacher, implying a teacher-centred view of the case study as a learning strategy. Little is known about the student perspective on case studies. If we are to use the case study method as a component of a student-centred learning experience, then we must know how students perceive case studies, and understand the differences in attitude...

  11. Arabidopsis in Wageningen

    OpenAIRE

    Koornneef, M

    2013-01-01

    Arabidopsis thaliana is the plant species that in the past 25 years has developed into the major model species in plant biology research. This was due to its properties such as short generation time, its small genome and its easiness to be transformed. Wageningen University has played an important role in the development of this model, based on interdisciplinary collaborations using genetics as a major tool to investigate aspects of physiology, development, plant-microbe interactions and evol...

  12. Where Does Literary Study Happen? Two Case Studies

    Science.gov (United States)

    Billington, Josie; Sperlinger, Tom

    2011-01-01

    This article explores the question of where literary study happens through reflection on two case studies. The article examines projects within two UK English departments, which were designed to allow students of literature to engage with local communities as part of their studies. The implications of this work are considered for curriculum…

  13. Pool size measurements facilitate the determination of fluxes at branching points in nonstationary metabolic flux analysis: The case of Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Robert eHeise

    2015-06-01

    Full Text Available Pool size measurements are important for the estimation of absolute intracellular fluxes in particular scenarios based on data from heavy carbon isotope experiments. Recently, steady-state fluxes estimates were obtained for central carbon metabolism in an intact illuminated rosette of Arabidopsis thaliana grown photoautotrophically (Szecowka et al., 2013; Heise et al., 2014. Fluxes were estimated therein by integrating mass-spectrometric data of the dynamics of the unlabeled metabolic fraction, data on metabolic pool sizes, partitioning of metabolic pools between cellular compartments and estimates of photosynthetically inactive pools, with a simplified model of plant central carbon metabolism. However, the fluxes were determined by treating the pool sizes as fixed parameters. Here we investigated whether and, if so, to what extent the treatment of pool sizes as parameters to be optimized in three scenarios may affect the flux estimates. The results are discussed in terms of benchmark values for canonical pathways and reactions, including starch and sucrose synthesis as well as the ribulose-1,5-bisphosphate carboxylation and oxygenation reactions. In addition, we discuss pathways emerging from a divergent branch point for which pool sizes are required for flux estimation, irrespective of the computational approach used for the simulation of the observable labelling pattern. Therefore, our findings indicate the necessity for development of techniques for accurate pool size measurements to improve the quality of flux estimates from nonstationary flux estimates in intact plant cells in the absence of alternative flux measurements.

  14. Dieulafoy's lesion: A case series study

    Institute of Scientific and Technical Information of China (English)

    RS Walmsley; Yuk-Tong Lee; Joseph JY Sung

    2005-01-01

    AIM: Dieulafoy's lesion (DL) accounts for 1-5.8% of cases of acute upper gastrointestinal bleeding (GIB). Its mortality is high, approaching 20%, despite recent advances in endoscopic therapy. We aimed to report our experience in the treatment of DL.METHODS: A retrospective case study of all patients with DL between January 1993 and January 2003 was done. Characteristics, treatment methods, success rates and 30-d mortality of the patients were analyzed. RESULTS: Thirty-six patients were noted to have DL in the study period. Thirty-three records were available for assessment in which 35 DL were identified. The median age of the patients was 67 years with male to female ratio of 5.6:1. Significant comorbidities existed in 69% of the patients. Eighty-nine percent of the DL was found at first endoscopy, three DL at laparotomy. Significant coexistent endoscopic findings existed in 23%. Hemostasis was achieved in 88% by using adrenaline injection, or in combination with heater probe application at first endoscopy. Four cases had re-bleeding, all were successfully treated endoscopically. The 30-d mortality rate was 23%.CONCLUSION: Successful endoscopic hemostasis could be achieved in 100% of cases of DL. The overall mortality may still remain high, mainly due to the comorbidities and age of these patients.

  15. Vitiligo: A study of 120 cases

    Directory of Open Access Journals (Sweden)

    Kar P

    2001-11-01

    Full Text Available Vitiligo is a common pignientary disorder and of major social and cosmetic concern in India. Purpose of the study was to find out age at onset and sex incidence in vitiligo, role of hereditary factors and associations with other diseases. 120 self reporting vitiligo patients attending out patient department of a service hospital were selected for the study and this data was analysed. In the present series out of 120 cases 62 (51.6% were males and 58(48.35%were females. There was practically no difference in sex incidence. The lowest age of onset was two years and the oldest was 65 years. In the majority of patients,52(43.2%, disease started before twenty years of age.8 (6.6% cases gave definite family history of vitiligo. Exposed areas of the body were commonly affected in majority (66.6% of cases. The legs were commonest site of involvement in 60(50% cases. Circunicript type of vitiligo (46.6% was heading the list. Majority of patients (56.6% had multiple lesions. Diabetes mellitus was found in 2 (2.6% patients. Cause of vitiligo is still idiopathic. Hereditary factors hardly play any role in manifestation of vitiligo

  16. 3D gel map of Arabidopsis complex I

    OpenAIRE

    Katrin ePeters; Katharina eBelt; Hans-Peter eBraun

    2013-01-01

    Complex I has a unique structure in plants and includes extra subunits. Here, we present a novel study to define its protein constituents. Mitochondria were isolated from Arabidopsis thaliana cell cultures, leaves and roots. Subunits of complex I were resolved by 3D blue native (BN)/SDS/SDS-PAGE and identified by mass spectrometry. Overall, 55 distinct proteins were found, 7 of which occur in pairs of isoforms. We present evidence that Arabidopsis complex I consists of 49 distinct types of su...

  17. The Pendulum A Case Study in Physics

    CERN Document Server

    Baker, Gregory L

    2005-01-01

    The pendulum: a case study in physics is a unique book in several ways. Firstly, it is a comprehensive quantitative study of one physical system, the pendulum, from the viewpoint of elementary and more advanced classical physics, modern chaotic dynamics, and quantum mechanics. In addition, coupled pendulums and pendulum analogs of superconducting devices are also discussed. Secondly, this book treats the physics of the pendulum within a historical and cultural context,showing, for example, that the pendulum has been intimately connected with studies of the earth's density, the earth's motion,

  18. Management & Communication: Project Management Case Study

    CERN Multimedia

    Nathalie Dumeaux

    2004-01-01

    We are pleased to announce the recent launch of a new workshop on Project Management. This is designed for People with budgetary, scheduling and/or organizational responsibilities in a project or a sub-project. The objectives through a management case study specially suited to CERN are: to become familiar with modern management techniques in use for structuring, planning, scheduling, costing and progress monitoring of a project or a sub-project. to understand in-depth issues associated with Deliverable-oriented Project Management, Earned Value Management, Advanced Project Cost Engineering and Project Risk Management. The full description of this workshop can be found here. The next session will be held on 8 October 2004. If you are interested in this workshop, please contact Nathalie Dumeaux, email or 78144. Programme of Seminars October to December 2004 Situation : 21.09.2004 Séminaires bilingues Dates Jours Places disponibles Project Management Case study 8 October 1 oui Intr...

  19. Marketing and clinical trials: a case study

    Directory of Open Access Journals (Sweden)

    Entwistle Vikki A

    2007-11-01

    Full Text Available Abstract Background Publicly funded clinical trials require a substantial commitment of time and money. To ensure that sufficient numbers of patients are recruited it is essential that they address important questions in a rigorous manner and are managed well, adopting effective marketing strategies. Methods Using methods of analysis drawn from management studies, this paper presents a structured assessment framework or reference model, derived from a case analysis of the MRC's CRASH trial, of 12 factors that may affect the success of the marketing and sales activities associated with clinical trials. Results The case study demonstrates that trials need various categories of people to buy in – hence, to be successful, trialists must embrace marketing strategies to some extent. Conclusion The performance of future clinical trials could be enhanced if trialists routinely considered these factors.

  20. The Graduate Experience: Living and Studying Abroad (A Case Study

    Directory of Open Access Journals (Sweden)

    Rosario Hernández Castañeda

    2008-11-01

    Full Text Available This article is a qualitative case study describing the experience of Angélica an international graduate student from Latin America, who received her doctorate at the University of New Mexico in the United States. Her case demonstrated how administrators and faculty learn about the experience and struggles endured by international students, especially those who learned English a short time before admission to graduate studies. While a single case is understandably idiographic in nature and inevitably requires a larger sample, from the analysis of Angélica’s case and the analysis of the relevant literature common topics emerged persuading me to conclude that the issues that commonly impact the life of international students have to do with: 1 second language problems; 2 the quality of academic advisement received; 3 the availability of financial support; 4 the level of integration into their academic program; and 5 the level of cultural adjustment in their host country.

  1. Gamification in teaching music : case study

    OpenAIRE

    Gomes, Cristina; Figueiredo, Mauro; Bidarra, José

    2014-01-01

    The study presented here aims to assess the quality of learning that occurred by the introduction of an educational application in the teaching/learning process of music education – 2nd cycle of basic education. The investigation focused on the use of a set of multimedia materials designed to provide support for instrumental practice (recorder and guitar) and backing vocals, according to the technique of the sing along. The students had access to the materials in two ways: in the first case, ...

  2. Case Study on Inventory Management Improvement

    OpenAIRE

    Plinere Darya; Borisov Arkady

    2015-01-01

    Inventory management is a challenging problem area in supply chain management. Companies need to have inventories in warehouses in order to fulfil customer demand, meanwhile these inventories have holding costs and this is frozen fund that can be lost. Therefore, the task of inventory management is to find the quantity of inventories that will fulfil the demand, avoiding overstocks. This paper presents a case study for the assembling company on inventory management. It is proposed to use inve...

  3. BOOK REVIEW: Case Studies in Knowledge Management

    OpenAIRE

    BOYACI, Reviewed By Dr. Adnan

    2005-01-01

    161Case Studies in Knowledge ManagementEdited by Murray JennexHersley: PA: Idea Group, 2005, pp. 372, ISBN 1-59140-352-9Reviewed by Dr. Adnan BOYACIAnadolu UniversityEskişehir-TurkeyKnowledge management (KM) as a structured system and the way to the effectiveness isrelatively new field for the contemporary organizations functioning in different andcompetitive domain of public and private sectors in terms of getting optimal effectivenessunderlined by the concepts such as quality, productivity…...

  4. A Codesign Case Study in Computer Graphics

    OpenAIRE

    Brage, Jens P.; Madsen, Jan

    1994-01-01

    The paper describes a codesign case study where a computer graphics application is examined with the intention to speed up its execution. The application is specified as a C program, and is characterized by the lack of a simple compute-intensive kernel. The hardware/software partitioning is based on information obtained from software profiling and the resulting design is validated through cosimulation. A locally developed interface model, Merlin, is used as the basis for co-simulation. The ac...

  5. Six case studies of contents tourism

    OpenAIRE

    Seaton, Philip

    2015-01-01

    This short series of research notes brings together some of the case studies that have been researched by members of the project ‘International Comparative Research on the Spreading and Reception of Culture through Contents Tourism’. This research has been funded since April 2014 by a Japan Society for the Promotion of Science grant (Kiban A, grant number 26243007). However, the project had its roots in a small group research project started in the Research Faculty of Media and...

  6. Case Study for Holylight(HK)

    OpenAIRE

    Ha, Kong Ho

    2013-01-01

    In this thesis the case company – Holylight (HK) was thoroughly studied. The company structure, business strategic management and Marketing mix (4ps) were analyzed using SWOT analysis. It was found that Holylight (HK) had huge poten-tial in the business its stable supplies from the United States of America, Europe and Australia; Alliance partnership company ensure the steady sales channel in potential market – China that further development and expansion are highly feasible. However th...

  7. Telepractice for Pediatric Dysphagia: A Case Study

    OpenAIRE

    Malandraki, Georgia A.; Melissa Roth; Justine Joan Sheppard

    2014-01-01

    A closed-ended intensive pediatric swallowing telepractice program was developed and piloted in one pediatric patient with Opitz BBB/G and Asperger’s Syndromes, oropharyngeal dysphagia and aerophagia. The present study is a case report. Outcome variables included behavioral, swallowing and quality of life variables, and were assessed at baseline and at the end of the four-week program. Selective variables were also assessed at a follow-up family interview four weeks post program completion. O...

  8. Hawaii Macadamia Nut Company- A Case Study

    OpenAIRE

    George H. (Jody) Tompson; Dan Verreault; Tompson, Holly B.

    2009-01-01

    Owners of the Hawaii Macadamia Nut Company (HMNC) are facing an expansion opportunity. A land owner has preperty available that would enable the HMNC to expand its acreage and revenue by about 20%. To fully consider this opportunity the owners must decide 1)whether the expansion is strategically and financially viable, 2)how to raise capital to finance the expansion, and 3)whether they have the skills to manage the company's growth during expansion. This is a case study describing a real comp...

  9. Web Fuzzy Clustering and a Case Study

    Institute of Scientific and Technical Information of China (English)

    LIU Mao-fu; HE Jing; HE Yan-xiang; HU Hui-jun

    2004-01-01

    We combine the web usage mining and fuzzy clustering and give the concept of web fuzzy clustering, and then put forward the web fuzzy clustering processing model which is discussed in detail. Web fuzzy clustering can be used in the web users clustering and web pages clustering. In the end, a case study is given and the result has proved the feasibility of using web fuzzy clustering in web pages clustering.

  10. Systemic Design: Two Canadian Case Studies

    OpenAIRE

    Alex Ryan; Mark Leung

    2014-01-01

    This paper introduces two novel applications of systemic design to facilitate a comparison of alternative methodologies that integrate systems thinking and design. In the first case study, systemic design helped the Procurement Department at the University of Toronto re-envision how public policy is implemented and how value is created in the broader university purchasing ecosystem. This resulted in an estimated $1.5 million in savings in the first year, and a rise in user retention rates fro...

  11. Private power financing: a case study

    International Nuclear Information System (INIS)

    The Public Utility Regulatory Power Act (PURPA) in the USA and the UK's Electricity Act passed in 1989 are discussed and the first UK private power project is considered. A case study is presented, and covers the questions of when to approach the bank; banker versus investment bank; project fundamentals; the sponsor and the management team; the strength of the key project agreements; syndication of the project debt; and bank support during construction and operation. (author)

  12. Neuropathology of supercentenarians - four autopsy case studies.

    Science.gov (United States)

    Takao, Masaki; Hirose, Nobuyoshi; Arai, Yasumichi; Mihara, Ban; Mimura, Masaru

    2016-01-01

    Supercentenarians (aged 110 years old or more) are extremely rare in the world population (the number of living supercentenarians is estimated as 47 in the world), and details about their neuropathological information are limited. Based on previous studies, centenarians (aged 100-109 years old) exhibit several types of neuropathological changes, such as Alzheimer's disease and Lewy body disease pathology, primary age-related tauopathy, TDP-43 pathology, and hippocampal sclerosis. In the present study, we provide results from neuropathological analyses of four supercentenarian autopsy cases using conventional and immunohistochemical analysis for neurodegenerative disorders. In particular, we focused on the pathology of Alzheimer's disease and Lewy body disease, as well as the status of hippocampal sclerosis, TDP-43 pathology, aging-related tau astrogliopathy, and cerebrovascular diseases. Three cases were characterized as an "intermediate" level of Alzheimer's disease changes (NIA-AA guideline) and one was characterized as primary age-related tauopathy. TDP-43 deposits were present in the hippocampus in two cases. Neither Lewy body pathology nor hippocampal sclerosis was observed. Aging-related tau astrogliopathy was consistently observed, particularly in the basal forebrain. Small vessel diseases were also present, but they were relatively mild for cerebral amyloid-beta angiopathy and arteriolosclerosis. Although our study involved a small number of cases, the results provide a better understanding about human longevity. Neuropathological alterations associated with aging were mild to moderate in the supercentenarian brain, suggesting that these individuals might have some neuroprotective factors against aging. Future prospective studies and extensive molecular analyses are needed to determine the mechanisms of human longevity. PMID:27590044

  13. Customer Buying Behavior : Case Study: Algol Technics

    OpenAIRE

    Weckman, Nina

    2009-01-01

    The purpose of this study is to research the customer buying behavior in a specific market. This thesis is made for a subgroup of Algol Technics which specializes in the marketing of driver seats. The research areas included brand recognition, price and quality, as well as the communications channels. The theoretical framework presented consists of the marketing strategies, marketing mix, Porter’s five forces analysis, customer relationship marketing, and market analysis. The case compan...

  14. Marketing and clinical trials: a case study

    OpenAIRE

    Entwistle Vikki A; Snowdon Claire; Garcia Jo; Knight Rosemary C; Shakur Haleema; Elbourne Diana R; Roberts Ian; Francis David; McDonald Alison M; Grant Adrian M; Campbell Marion K

    2007-01-01

    Abstract Background Publicly funded clinical trials require a substantial commitment of time and money. To ensure that sufficient numbers of patients are recruited it is essential that they address important questions in a rigorous manner and are managed well, adopting effective marketing strategies. Methods Using methods of analysis drawn from management studies, this paper presents a structured assessment framework or reference model, derived from a case analysis of the MRC's CRASH trial, o...

  15. Case studies of soil in art

    Science.gov (United States)

    Feller, C.; Landa, E. R.; Toland, A.; Wessolek, G.

    2015-08-01

    The material and symbolic appropriations of soil in artworks are numerous and diverse, spanning many centuries and artistic traditions, from prehistoric painting and ceramics to early Renaissance works in Western literature, poetry, paintings, and sculpture, to recent developments in film, architecture, and contemporary art. Case studies focused on painting, installation, and film are presented with the view of encouraging further exploration of art about, in, and with soil as a contribution to raising soil awareness.

  16. Concentrated Photo Voltaics (CPV: a case study

    Directory of Open Access Journals (Sweden)

    Centro S.

    2015-01-01

    Full Text Available Concentrated PhotoVoltaic (CPV, among green energy solutions, nowadays has the ambition to reach grid-parity without subside. CPV substitutes large areas of expensive semiconductor solar cells, with concentrating optics made of cheap materials. Moreover the cells that are suitable for CPV exhibits an unprecedented efficiency and their technology is progressing every year. A case study project, TwinFocus®, will be presented in detail.

  17. Nucleotide Variation in the NCED3 Region of Arabidopsis thaliana and its Association Study with Abscisic Acid Content under Drought Stress

    Institute of Scientific and Technical Information of China (English)

    Gang-Ping Hao; Xiu-Hai Zhang; Yong-Qin Wang; Zhong-Yi Wu; Cong-Lin Huang

    2009-01-01

    Drought tolerance is a comprehensive quantitative trait that is being understood further at the molecular genetic level. Abscisic acid (ABA) is the main drought-induced hormone that regulates the expression of many genes related to drought responses. 9-cis-epoxycarotenoid dioxygenase (NCED3) is thought to be a key enzyme in ABA biosynthesis. In this paper, we measured the ABA content increase under drought stress, and sequenced and compared the sequence of AtNCED3 among 22 Arabidopsis thaliana accessions. The results showed that the fold of ABA content increase under drought stress was highly variable among these accessions. High density single nucleotide polymorphism (SNP) and insertion/deletion (indel) were found in the AtNCED3 region, on average one SNP per 87.4 bp and one indel per 502 bp. Nucleotide diversity was significantly lower in the coding region than that in non-coding regions. The results of an association study with ANOVA analysis suggested that the 274th site (P←→S) and the 327th site (P←→R) amino acid variations might be the cause of ABA content increase of 163av accession under drought stress.

  18. Genome-Wide Association Study in Arabidopsis thaliana of Natural Variation in Seed Oil Melting Point: A Widespread Adaptive Trait in Plants.

    Science.gov (United States)

    Branham, Sandra E; Wright, Sara J; Reba, Aaron; Morrison, Ginnie D; Linder, C Randal

    2016-05-01

    Seed oil melting point is an adaptive, quantitative trait determined by the relative proportions of the fatty acids that compose the oil. Micro- and macro-evolutionary evidence suggests selection has changed the melting point of seed oils to covary with germination temperatures because of a trade-off between total energy stores and the rate of energy acquisition during germination under competition. The seed oil compositions of 391 natural accessions of Arabidopsis thaliana, grown under common-garden conditions, were used to assess whether seed oil melting point within a species varied with germination temperature. In support of the adaptive explanation, long-term monthly spring and fall field temperatures of the accession collection sites significantly predicted their seed oil melting points. In addition, a genome-wide association study (GWAS) was performed to determine which genes were most likely responsible for the natural variation in seed oil melting point. The GWAS found a single highly significant association within the coding region of FAD2, which encodes a fatty acid desaturase central to the oil biosynthesis pathway. In a separate analysis of 15 a priori oil synthesis candidate genes, 2 (FAD2 and FATB) were located near significant SNPs associated with seed oil melting point. These results comport with others' molecular work showing that lines with alterations in these genes affect seed oil melting point as expected. Our results suggest natural selection has acted on a small number of loci to alter a quantitative trait in response to local environmental conditions. PMID:26865732

  19. Systemic Design: Two Canadian Case Studies

    Directory of Open Access Journals (Sweden)

    Alex Ryan

    2014-12-01

    Full Text Available This paper introduces two novel applications of systemic design to facilitate a comparison of alternative methodologies that integrate systems thinking and design. In the first case study, systemic design helped the Procurement Department at the University of Toronto re-envision how public policy is implemented and how value is created in the broader university purchasing ecosystem. This resulted in an estimated $1.5 million in savings in the first year, and a rise in user retention rates from 40% to 99%. In the second case study, systemic design helped the clean energy and natural resources group within the Government of Alberta to design a more efficient and effective resource management system and shift the way that natural resource departments work together. This resulted in the formation of a standing systemic design team and contributed to the creation of an integrated resource management system. A comparative analysis of the two projects identifies a shared set of core principles for systemic design as well as areas of differentiation that reveal potential for learning across methodologies. Together, these case studies demonstrate the complementarity of systems thinking and design thinking, and show how they may be integrated to guide positive change within complex sociotechnical systems.

  20. Shuttle Transportation System Case-Study Development

    Science.gov (United States)

    Ransom, Khadijah

    2012-01-01

    A case-study collection was developed for NASA's Space Shuttle Program. Using lessons learned and documented by NASA KSC engineers, analysts, and contractors, decades of information related to processing and launching the Space Shuttle was gathered into a single database. The goal was to provide educators with an alternative means to teach real-world engineering processes and to enhance critical thinking, decision making, and problem solving skills. Suggested formats were created to assist both external educators and internal NASA employees to develop and contribute their own case-study reports to share with other educators and students. Via group project, class discussion, or open-ended research format, students will be introduced to the unique decision making process related to Shuttle missions and development. Teaching notes, images, and related documents will be made accessible to the public for presentation of Space Shuttle reports. Lessons investigated included the engine cutoff (ECO) sensor anomaly which occurred during mission STS-114. Students will be presented with general mission infom1ation as well as an explanation of ECO sensors. The project will conclude with the design of a website that allows for distribution of information to the public as well as case-study report submissions from other educators online.

  1. Natural genetic variation in Arabidopsis for responsiveness to plant growth-promoting rhizobacteria

    OpenAIRE

    Wintermans, P.C.A.; Bakker, P.A.H.M.; Pieterse, C.M.J.

    2016-01-01

    The plant growth-promoting rhizobacterium (PGPR) Pseudomonas simiae WCS417r stimulates lateral root formation and increases shoot growth in Arabidopsis thaliana (Arabidopsis). These plant growth-stimulating effects are partly caused by volatile organic compounds (VOCs) produced by the bacterium. Here, we performed a genome-wide association (GWA) study on natural genetic variation in Arabidopsis for the ability to profit from rhizobacteria-mediated plant growth-promotion. To this end, 302 Arab...

  2. Capturing Cultural Glossaries: Case-study II

    Directory of Open Access Journals (Sweden)

    Matete Madiba

    2011-10-01

    Full Text Available

    ABSTRACT: This case-study attempts to present a brief glossary of Northern Sotho medical terms. It is a follow-up of a similar case-study (Madiba, Mphahlele and Kganyago 2003, which was an attempt to capture and present Northern Sotho cooking terms. Case-study I consists of the names for utensils, ingredients and the processes involved in the preparation of cultural dishes. With both these case-studies, the intention has been to use the opportunities availing themselves for the pres-ervation and valorisation of Northern Sotho, including the extension of its corpora to support national dictionary-making processes. The case-study methodology has been very useful for the purposes of this project and the context within which it was undertaken. It aims to provide a model for the collection and presentation of authentic Northern Sotho terminology which otherwise would hardly have been accessible.

    Keywords: CULTURAL GLOSSARY, INDIGENOUS KNOWLEDGE SYSTEMS, CORPUS, OUTCOMES-BASED EDUCATION, ASSESSMENT CRITERIA, TRADITIONAL MEDICAL TERMS, COMMUNICATIVE APPROACH, STRUCTURAL APPROACH, METONYMY, HANDS-ON ACTIVITIES, TASK-BASED LEARNING

    *****

    OPSOMMING: Die totstandbrenging van kulturele woordversamelings: Ge-vallestudie II. Hierdie gevallestudie probeer om 'n beperkte woordelys van Noord-Sotho- mediese terme aan te bied. Dit is 'n voortsetting van 'n soortgelyke gevallestudie (Madiba, Mpha-hlele en Kganyago 2003 wat 'n poging was om Noord-Sothokookterme te versamel en aan te bied. Gevallestudie I bestaan uit die name van gereedskap, bestanddele, en die prosesse betrokke by die voorbereiding van kulturele geregte. Met altwee hierdie gevallestudies was die bedoeling om die geleenthede te gebruik wat hulleself aanbied vir die bewaring en bestendiging van Noord-Sotho, insluitende die uitbreiding van sy korpora om die nasionale woordeboeksamestellingsprosesse te ondersteun. Die gevallestudiemetodologie was baie nuttig vir die doeleindes van

  3. Case studies in atomic collision physics

    CERN Document Server

    McDaniel, E W

    2013-01-01

    Case Studies in Atomic Collision Physics II focuses on studies on the role of atomic collision processes in astrophysical plasmas, including ionic recombination, electron transport, and position scattering. The book first discusses three-body recombination of positive and negative ions, as well as introduction to ionic recombination, calculation of the recombination coefficient, ions recombining in their parent gas, and three-body recombination at moderate and high gas-densities. The manuscript also takes a look at precision measurements of electron transport coefficients and differential cr

  4. A CASE STUDY ON MEASUREMENT EFFECTIVENESS

    Directory of Open Access Journals (Sweden)

    Vladimír Modrák

    2007-03-01

    Full Text Available Ensuring the measurement effectiveness of Cost of Quality (COQ implementations presents steadily a practical managerial problem. Even though there are many approaches to measurement COQ optimal methods for this purpose in real conditions often depend on confrontation and evaluation of different calculation models. The paper based on a case study describes a procedure for comparison between so called controllable costs and incurred cost of poor quality. Presented study confirms assumption of a propitious influence of preventive costs on an overall COQ and a change of structure of separate cost of quality items.

  5. Case study of isosurface extraction algorithm performance

    Energy Technology Data Exchange (ETDEWEB)

    Sutton, P M; Hansen, C D; Shen, H; Schikore, D

    1999-12-14

    Isosurface extraction is an important and useful visualization method. Over the past ten years, the field has seen numerous isosurface techniques published leaving the user in a quandary about which one should be used. Some papers have published complexity analysis of the techniques yet empirical evidence comparing different methods is lacking. This case study presents a comparative study of several representative isosurface extraction algorithms. It reports and analyzes empirical measurements of execution times and memory behavior for each algorithm. The results show that asymptotically optimal techniques may not be the best choice when implemented on modern computer architectures.

  6. Using Case Studies to Teach About Global Issues, Bali: A Case Study

    Science.gov (United States)

    Oswald, James M.

    1974-01-01

    The South Pacific island of Bali is used as a case study of overpopulation and food shortage. A brief description of the resources, the typical lifestyle of the Balinese farmer, and possible teaching techniques are given. (DE)

  7. Phototropism and gravitropism in lateral roots of Arabidopsis.

    Science.gov (United States)

    Kiss, John Z; Miller, Kelley M; Ogden, Lisa A; Roth, Kelly K

    2002-01-01

    Gravitropism and, to a lesser extent, phototropism have been characterized in primary roots, but little is known about structural/functional aspects of these tropisms in lateral roots. Therefore, in this study, we report on tropistic responses in lateral roots of Arabidopsis thaliana. Lateral roots initially are plagiogravitropic, but when they reach a length of approximately 10 mm, these roots grow downward and exhibit positive orthogravitropism. Light and electron microscopic studies demonstrate a correlation between positive gravitropism and development of columella cells with large, sedimented amyloplasts in wild-type plants. Lateral roots display negative phototropism in response to white and blue light and positive phototropism in response to red light. As is the case with primary roots, the photoresponse is weak relative to the graviresponse, but phototropism is readily apparent in starchless mutant plants, which are impaired in gravitropism. To our knowledge, this is the first report of phototropism of lateral roots in any plant species.

  8. The case study of biomaterials and biominerals

    Science.gov (United States)

    Del Hoyo Martínez, Carmen

    2013-04-01

    The teaching of biomaterials as case study by on-line platform , susceptible to develop both individually and in groups, got different objectives proposed by the European Higher Education System, among which include: participate actively in the teaching-learning process by students, interpreting situations, adapt processes and solutions. It also improves oral and written communication, analytical skills and synthesis and also the ability to think critically. Biomaterials have their origin in biominerals. These are solid inorganic compounds of defined structure, consisting of molecular control mechanisms that operate in biological systems. Its main functions are: structural support, a reservoir of essential elements, sensors, mechanical protection and storage of toxic elements. Following the demand of materials compatible with certain functional systems of our body, developed biomaterials. Always meet the condition of biocompatibility. Should be tolerated by the body and do not provoke rejection. This involves a comprehensive study of physiological conditions and the anatomy of the body where a biomaterial has to be implemented. The possibility of generating new materials from biominerals has a major impact in medicine and other fields could reach as geology, construction, crystallography, etc. While the study of these issues is in its infancy today, can be viewed as an impact on the art and future technology. Planning case study that students would prepare its report for discussion in subgroups. Occurs then the pooling of individual analysis, joint case discussion and adoption by the subgroup of a consensual solution to the problem. The teacher as facilitator and coordinator of the final case analysis, sharing leads to group-wide class and said the unanimous decision reached by the students and gives his opinion on the resolution of the case. REFERENCES D.P. Ausubel. Psicología Educativa. Un punto de vista cognoscitivo. Trillas. Ed. 1983. E.W. Eisner. Procesos

  9. Studies on the role of heavy-metal transporting P-type ATPase family genes on zinc (Zn) transport and accumulation in Arabidopsis thaliana

    Energy Technology Data Exchange (ETDEWEB)

    Bagavathiannan, M.V. [Manitoba Univ., Winnipeg, MB (Canada). Dept. of Plant Science; Broadley, M.R.; Donnelly, S.J.; Smith, R.J.; Mills, V. [Nottingham Univ., Loughborough, Leicestershire (United Kingdom). School of Biosciences, Plant Sciences Division

    2006-07-01

    Although zinc (Zn) is an essential plant mineral nutrient for normal crop growth, excess amounts can cause environmental contamination problems. Higher amounts of Zn are added into soils every year through effluents from tanning industries and other sources such as sewage treatment plants, metal inputs from rivers and the atmosphere. Studies have shown that specific metal tolerances exist at the cellular level in plants, indicating that specific adaptations to metal ions occur in cells as well as in the whole plant. This paper described the mechanisms that plants develop in order to tolerate heavy metals and showed that transporter genes play a key role in uptake and sequestration of heavy metals in plant systems. Since metal ion transporting genes are also involved in transport and homeostasis of heavy metals in plants, this study examined the role of the metal ion transporting gene family members in Zn transport and tolerance in plant systems. Among the metal ion transporting gene families, P-type ATPase gene family members are considered to be efficient in metal transport in the model plant Arabidopsis thaliana. They form a diverse superfamily of transporters which carry a range of essential and potentially toxic metals across cellular membranes. Genetic-screening experiments were performed in which 3 SALK lines with known disruption in the target gene were studied physiologically and at the molecular level to determine their role in heavy-metal transportation and accumulation. The study showed that one of the family lines may have altered Zn tolerance and uptake characteristics. Ongoing research continues to examine the characteristics of this line. 27 refs., 1 tab., 8 figs.

  10. Forecast Master Program case studies: Final report

    Energy Technology Data Exchange (ETDEWEB)

    Engle, R.; Granger, C.; Ramanathan, R. (ed.)

    1987-04-01

    This report presents a number of case studies using the computer software package FORECAST MASTER (FM). The series studied and forecast are, aggregate monthly California Electricity Sales, system energy demand data from Ontario Hydro, peak demand data for the residential and commercial customers of Georgia Power Company, Massachusetts Electric commercial sales, Narragansett Electric commercial sales, average and peak demand using Georgia Power Company data. A variety of methods have been studied by each of the contributing authors; trend line fitting, exponential smoothing, Box-Jenkins univariate forecasting, vector autoregression, state space modeling, dynamic econometric models including time-varying parameters and general order serial correlation corrections. Thus both the data sets and the modeling/forecasting methodologies are varied. A number of conclusions emerge from these case studies: FM provides a powerful set of tools to aid a utility forecaster, a great deal of caution should be exercised in pre-processing the data; it can have unintended side effects, diagnostic tests are very useful in econometric models, the Akaike Information Criterion is a useful measure for selecting the best state space model, and state space and econometric approaches both need equal amounts of care in model analysis and presentation.

  11. In Vitro Morphogenesis of Arabidopsis to Search for Novel Endophytic Fungi Modulating Plant Growth.

    Directory of Open Access Journals (Sweden)

    Francesco Dovana

    Full Text Available Fungal endophytes have shown to affect plant growth and to confer stress tolerance to the host; however, effects of endophytes isolated from water plants have been poorly investigated. In this study, fungi isolated from stems (stem-E and roots (root-E of Mentha aquatica L. (water mint were identified, and their morphogenetic properties analysed on in vitro cultured Arabidopsis (L. Heynh., 14 and 21 days after inoculation (DAI. Nineteen fungi were analysed and, based on ITS analysis, 17 isolates showed to be genetically distinct. The overall effect of water mint endophytes on Arabidopsis fresh (FW and dry weight (DW was neutral and positive, respectively, and the increased DW, mainly occurring 14 DAI, was possibly related to plant defence mechanism. Only three fungi increased both FW and DW of Arabidopsis at 14 and 21 DAI, thus behaving as plant growth promoting (PGP fungi. E-treatment caused a reduction of root depth and primary root length in most cases and inhibition-to-promotion of root area and lateral root length, from 14 DAI. Only Phoma macrostoma, among the water mint PGP fungi, increased both root area and depth, 21 DAI. Root depth and area 14 DAI were shown to influence DWs, indicating that the extension of the root system, and thus nutrient uptake, was an important determinant of plant dry biomass. Reduction of Arabidopsis root depth occurred to a great extent when plants where treated with stem-E while root area decreased or increased under the effects of stem-E and root-E, respectively, pointing to an influence of the endophyte origin on root extension. M. aquatica and many other perennial hydrophytes have growing worldwide application in water pollution remediation. The present study provided a model for directed screening of endophytes able to modulate plant growth in the perspective of future field applications of these fungi.

  12. Wind to Hydrogen in California: Case Study

    Energy Technology Data Exchange (ETDEWEB)

    Antonia, O.; Saur, G.

    2012-08-01

    This analysis presents a case study in California for a large scale, standalone wind electrolysis site. This is a techno-economic analysis of the 40,000 kg/day renewable production of hydrogen and subsequent delivery by truck to a fueling station in the Los Angeles area. This quantity of hydrogen represents about 1% vehicle market penetration for a city such as Los Angeles (assuming 0.62 kg/day/vehicle and 0.69 vehicles/person) [8]. A wind site near the Mojave Desert was selected for proximity to the LA area where hydrogen refueling stations are already built.

  13. Case Study of the California Cement Industry

    OpenAIRE

    Coito, Fred; Powell, Frank; Worrell, Ernst; Price, Lynn; Friedmann, Rafael

    2005-01-01

    California is the largest cement producing state in the U.S., accounting for between 10 percent and 15 percent of U.S. cement production and cement industry employment. The cement industry in California consists of 31 sites that consume large amounts of energy, annually: 1,600 GWh of electricity, 22 million therms of natural gas, 2.3 million tons of coal, 0.25 tons of coke, and smaller amounts of waste materials, including tires. The case study summarized in this paper focused on providi...

  14. Russian Media Educators: Case Studies Portraits

    Directory of Open Access Journals (Sweden)

    Alexander Fedorov

    2013-01-01

    Full Text Available This article is devoted to case studies of the media education works of some well knowns Russian media educators. The analysis of media educational work of the famous Russian media educators leads us to the conclusion that media education in Russia is developing, building on the synthesis of the aesthetic, socio-cultural, and practical concepts, with a focus on the development of media competence of the audience, mainly school and youth. The enthusiasts of media education, even devoid of substantial public support for its innovative projects, achieve significant and meaningful results.

  15. A Codesign Case Study in Computer Graphics

    DEFF Research Database (Denmark)

    Brage, Jens P.; Madsen, Jan

    1994-01-01

    The paper describes a codesign case study where a computer graphics application is examined with the intention to speed up its execution. The application is specified as a C program, and is characterized by the lack of a simple compute-intensive kernel. The hardware/software partitioning is based...... on information obtained from software profiling and the resulting design is validated through cosimulation. A locally developed interface model, Merlin, is used as the basis for co-simulation. The achieved speed-up is estimated based on an analysis of profile information....

  16. Centralized vs. Distributed Databases. Case Study

    Directory of Open Access Journals (Sweden)

    Nicoleta Magdalena Iacob

    2015-12-01

    Full Text Available Currently, in information technology domain and implicit in databases domain can be noticed two apparently contradictory approaches: centralization and distribution respectively. Although both aim to produce some benefits, it is a known fact that for any advantage a price must be paid. In addition, in this paper we have presented a case study, e-learning portal performance optimization by using distributed databases technology. In the stage of development in which institutions have branches distributed over a wide geographic area, distributed database systems become more appropriate to use, because they offer a higher degree of flexibility and adaptability then centralized ones.

  17. Case studies in Bayesian microbial risk assessments

    Directory of Open Access Journals (Sweden)

    Turner Joanne

    2009-12-01

    Full Text Available Abstract Background The quantification of uncertainty and variability is a key component of quantitative risk analysis. Recent advances in Bayesian statistics make it ideal for integrating multiple sources of information, of different types and quality, and providing a realistic estimate of the combined uncertainty in the final risk estimates. Methods We present two case studies related to foodborne microbial risks. In the first, we combine models to describe the sequence of events resulting in illness from consumption of milk contaminated with VTEC O157. We used Monte Carlo simulation to propagate uncertainty in some of the inputs to computer models describing the farm and pasteurisation process. Resulting simulated contamination levels were then assigned to consumption events from a dietary survey. Finally we accounted for uncertainty in the dose-response relationship and uncertainty due to limited incidence data to derive uncertainty about yearly incidences of illness in young children. Options for altering the risk were considered by running the model with different hypothetical policy-driven exposure scenarios. In the second case study we illustrate an efficient Bayesian sensitivity analysis for identifying the most important parameters of a complex computer code that simulated VTEC O157 prevalence within a managed dairy herd. This was carried out in 2 stages, first to screen out the unimportant inputs, then to perform a more detailed analysis on the remaining inputs. The method works by building a Bayesian statistical approximation to the computer code using a number of known code input/output pairs (training runs. Results We estimated that the expected total number of children aged 1.5-4.5 who become ill due to VTEC O157 in milk is 8.6 per year, with 95% uncertainty interval (0,11.5. The most extreme policy we considered was banning on-farm pasteurisation of milk, which reduced the estimate to 6.4 with 95% interval (0,11. In the second

  18. Metrology in Pharmaceutical Industry - A Case Study

    Science.gov (United States)

    Yuvamoto, Priscila D.; Fermam, Ricardo K. S.; Nascimento, Elizabeth S.

    2016-07-01

    Metrology is recognized by improving production process, increasing the productivity, giving more reliability to the measurements and consequently, it impacts in the economy of a country. Pharmaceutical area developed GMP (Good Manufacture Practice) requeriments, with no introduction of metrological concepts. However, due to Nanomedicines, it is expected this approach and the consequent positive results. The aim of this work is to verify the level of metrology implementation in a Brazilian pharmaceutical industry, using a case study. The purpose is a better mutual comprehension by both areas, acting together and governmental support to robustness of Brazilian pharmaceutical area.

  19. An Arabidopsis callose synthase

    DEFF Research Database (Denmark)

    Ostergaard, Lars; Petersen, Morten; Mattsson, Ole;

    2002-01-01

    in the Arabidopsis mpk4 mutant which exhibits systemic acquired resistance (SAR), elevated beta-1,3-glucan synthase activity, and increased callose levels. In addition, AtGsl5 is a likely target of salicylic acid (SA)-dependent SAR, since AtGsl5 mRNA accumulation is induced by SA in wild-type plants, while...... expression of the nahG salicylate hydroxylase reduces AtGsl5 mRNA levels in the mpk4 mutant. These results indicate that AtGsl5 is likely involved in callose synthesis in flowering tissues and in the mpk4 mutant....

  20. An investigation into the involvement of defense signaling pathways in components of the nonhost resistance of Arabidopsis thaliana to rust fungi also reveals a model system for studying rust fungal compatibility.

    Science.gov (United States)

    Mellersh, Denny G; Heath, Michèle C

    2003-05-01

    further fungal growth. The U. vignae-Arabidopsis combination could allow the application of the powerful genetic capabilities of this model plant to the study of compatibility as well as nonhost resistance to rust fungi.

  1. Comparative genomics of Gossypium and Arabidopsis: Unraveling the consequences of both ancient and recent polyploidy

    Science.gov (United States)

    Rong, Junkang; Bowers, John E.; Schulze, Stefan R.; Waghmare, Vijay N.; Rogers, Carl J.; Pierce, Gary J.; Zhang, Hua; Estill, James C.; Paterson, Andrew H.

    2005-01-01

    Both ancient and recent polyploidy, together with post-polyploidization loss of many duplicated gene copies, complicates angiosperm comparative genomics. To explore an approach by which these challenges might be mitigated, genetic maps of extant diploid and tetraploid cottons (Gossypium spp.) were used to infer the approximate order of 3016 loci along the chromosomes of their hypothetical common ancestor. The inferred Gossypium gene order corresponded more closely than the original maps did to a similarly inferred ancestral gene order predating an independent paleopolyploidization (α) in Arabidopsis. At least 59% of the cotton map and 53% of the Arabidopsis transcriptome showed correspondence in multilocus gene arrangements based on one or both of two software packages (CrimeStatII, FISH). Genomic regions in which chromosome structural rearrangement has been rapid (obscuring gene order correspondence) have also been subject to greater divergence of individual gene sequences. About 26%-44% of corresponding regions involved multiple Arabidopsis or cotton chromosomes, in some cases consistent with known, more ancient, duplications. The genomic distributions of multiple-locus probes provided early insight into the consequences for chromosome structure of an ancient large-scale duplication in cotton. Inferences that mitigate the consequences of ancient duplications improve leveraging of genomic information for model organisms in the study of more complex genomes. PMID:16109973

  2. Gravitropism in leaves of Arabidopsis thaliana (L.) Heynh.

    Science.gov (United States)

    Mano, Eriko; Horiguchi, Gorou; Tsukaya, Hirokazu

    2006-02-01

    In higher plants, stems and roots show negative and positive gravitropism, respectively. However, current knowledge on the graviresponse of leaves is lacking. In this study, we analyzed the positioning and movement of rosette leaves of Arabidopsis thaliana under light and dark conditions. We found that the radial positioning of rosette leaves was not affected by the direction of gravity under continuous white light. In contrast, when plants were shifted to darkness, the leaves moved upwards, suggesting negative gravitropism. Analysis of the phosphoglucomutase and shoot gravitropism 2-1 mutants revealed that the sedimenting amyloplasts in the leaf petiole are important for gravity perception, as is the case in stems and roots. In addition, our detailed physiological analyses revealed a unique feature of leaf movement after the shift to darkness, i.e. movement could be divided into negative gravitropism and nastic movement. The orientation of rosette leaves is ascribed to a combination of these movements.

  3. Genome-wide comparative analysis of type-A Arabidopsis response regulator genes by overexpression studies re-veals their diverse roles and regulatory mechanisms in cytokinin signaling

    Institute of Scientific and Technical Information of China (English)

    Bo Ren; Yan Liang; Yan Deng; Qingguo Chen; Jian Zhang; Xiaohui Yang; Jianru Zuo

    2009-01-01

    Cytokinin is a critical growth regulator for various aspects of plant growth and development. In Arabidopsis, cyto-kinin signaling is mediated by a two-component system-based phosphorelay that transmits a signal from the recep-tors, through histidine phosphotransfer proteins, to the downstream response regulators (ARRs). Of these ARRs, type-A ARR genes, whose transcription can be rapidly induced by cytokinin, act as negative regulators of cytokinin signaling. However, because of functional redundancy, the function of type-A ARR genes in plant growth and de-velopment is not well understood by analyzing loss-of-function mutants. In this study, we performed a comparative functional study on all ten type-A ARR genes by analyzing transgenic plants overexpressing these ARR genes fused to a MYC epitope tag. Overexpression of ARR genes results in a variety of cytokinin-associated phenotypes. Notably, overexpression of different ARR transgenes causes diverse phenotypes, even between phylogenetically closely-related gene pairs, such as within the ARR3-ARR4 and ARRS-ARR6 pairs. We found that the accumulation of a subset of ARR proteins (ARR3, ARR5, ARR7, ARR16 and ARR17; possibly ARR8 and ARR15) is increased by MGI32, a spe-cific proteasomal inhibitor, indicating that stability of these proteins is regulated by proteasomal degradation. More-over, similar to that of previously characterized ARR5, ARR6 and ARR7, stability of ARR16 and ARR17, possibly including ARR8 and ARRI5, is regulated by cytokinin. These results suggest that type-A ARR proteins are regulated by a combinatorial mechanism involving both the cytokinin and proteasome pathways, thereby executing distinctive functions in plant growth and development.

  4. The Effect of Using Case Studies in Business Statistics

    Science.gov (United States)

    Pariseau, Susan E.; Kezim, Boualem

    2007-01-01

    The authors evaluated the effect on learning of using case studies in business statistics courses. The authors divided students into 3 groups: a control group, a group that completed 1 case study, and a group that completed 3 case studies. Results evidenced that, on average, students whom the authors required to complete a case analysis received…

  5. Analyzing Synthetic Promoters Using Arabidopsis Protoplasts.

    Science.gov (United States)

    Stracke, Ralf; Thiedig, Katharina; Kuhlmann, Melanie; Weisshaar, Bernd

    2016-01-01

    This chapter describes a transient protoplast co-transfection method that can be used to quantitatively study in vivo the activity and function of promoters and promoter elements (reporters), and their induction or repression by transcription factors (effectors), stresses, hormones, or metabolites. A detailed protocol for carrying out transient co-transfection assays with Arabidopsis At7 protoplasts and calculating the promoter activity is provided. PMID:27557761

  6. Prehospital airway management: A prospective case study.

    Science.gov (United States)

    Wilbers, N E R; Hamaekers, A E W; Jansen, J; Wijering, S C; Thomas, O; Wilbers-van Rens, R; van Zundert, A A J

    2011-01-01

    We conducted a one-year prospective study involving a prehospital Emergency Medical Service in the Netherlands to investigate the incidence of failed or difficult prehospital endotracheal intubation. During the study period the paramedics were asked to fill in a registration questionnaire after every endotracheal intubation. Of the 26,271 patient contacts, 256 endotracheal intubations were performed by paramedics in one year. Endotracheal intubation failed in 12 patients (4.8%). In 12.0% of 249 patients, a Cormack and Lehane grade III laryngoscopy was reported and a grade IV laryngoscopy was reported in 10.4%. The average number of endotracheal intubations per paramedic in one year was 4.2 and varied from zero to a maximum of 12. The median time between arrival on the scene and a positive capnograph was 7 min.38 s in the case of a Cormack and Lehane grade I laryngoscopy and 14 min.58 s in the case of a Cormack and Lehane grade 4 laryngoscopy. The incidence of endotracheal intubations performed by Dutch paramedics in one year was low, but endotracheal intubation was successful in 95.2%, which is comparable with findings in international literature. Early capnography should be used consistently in prehospital airway management. PMID:21612142

  7. Case Study of the California Cement Industry

    Energy Technology Data Exchange (ETDEWEB)

    Coito, Fred; Powell, Frank; Worrell, Ernst; Price, Lynn; Friedmann, Rafael

    2005-05-01

    California is the largest cement producing state in theU.S., accounting for between 10 percent and 15 percent of U.S. cementproduction and cement industry employment. The cement industry inCalifornia consists of 31 sites that consume large amounts of energy,annually: 1,600 GWh of electricity, 22 million therms of natural gas, 2.3million tons of coal, 0.25 tons of coke, and smaller amounts of wastematerials, including tires. The case study summarized in this paperfocused on providing background information, an assessment ofenergy-efficiency opportunities and barriers, and program recommendationsthat can be used by program planners to better target products to thecement industry. The primary approach to this case study involvedwalk-through surveys of customer facilities and in depth interviews withcustomer decision makers and subsequent analysis of collected data. Inaddition, a basic review of the cement production process was developed,and summary cement industry energy and economic data were collected, andanalyzed. The analysis of secondary data provides background informationon the cement industry and identification of potential energy-efficiencyopportunities. The interviews provide some understanding of the customerperspective about implementation of energy-efficiencyprojects.

  8. Scheduling job shop - A case study

    Science.gov (United States)

    Abas, M.; Abbas, A.; Khan, W. A.

    2016-08-01

    The scheduling in job shop is important for efficient utilization of machines in the manufacturing industry. There are number of algorithms available for scheduling of jobs which depend on machines tools, indirect consumables and jobs which are to be processed. In this paper a case study is presented for scheduling of jobs when parts are treated on available machines. Through time and motion study setup time and operation time are measured as total processing time for variety of products having different manufacturing processes. Based on due dates different level of priority are assigned to the jobs and the jobs are scheduled on the basis of priority. In view of the measured processing time, the times for processing of some new jobs are estimated and for efficient utilization of the machines available an algorithm is proposed and validated.

  9. Nightmares and psychotic decompensation: a case study.

    Science.gov (United States)

    Levin, R; Daly, R S

    1998-01-01

    There have been numerous reports in the literature on the descriptive similarities between a severe nightmare and an acute psychotic episode. Nightmares may be a prelude to psychotic decompensation, and it has been suggested that frequent lifelong nightmares may even be diagnostic of an underlying vulnerability to psychosis. In this report, we present a case study of a 40-year old female experiencing chronic paranoid schizophrenia, whose two witnessed psychotic relapses in the hospital were immediately preceded by intense and vivid nightmare attacks. Significantly, the content of these nocturnal dreams was thematically consistent with her waking hallucinations, suggesting a direct continuity between these experiences. We propose that further systematic study of the dreams and nightmares of individuals diagnosed with schizophrenia may be particularly useful in understanding their phenomenological experience.

  10. Social Architecture: An Emergency Management Case Study

    Directory of Open Access Journals (Sweden)

    Asif Qumer Gill

    2015-03-01

    Full Text Available Emergency management agencies are progressively using social media for the sourcing and distribution of disaster information. Emergency management agencies are often unsure as to how to best identify and assess social media concerns (e.g. information security, trust which must be addressed to develop a social media-enabled disaster information management environment. This paper adopts the Social Architecture Viewpoint Assessment (SAVA framework for identifying and assessing social media concerns from four different viewpoints: IT, Value, Resource and Management. This paper demonstrates the use of the SAVA framework in the context of an in-depth empirical case study of an Australian emergency management agency. The results of this study indicate that the SAVA framework is useful for emergency information management managers in identifying and assessing social media concerns.

  11. Commercializing Emerging Renewable Energy: A Case Study

    Directory of Open Access Journals (Sweden)

    Matti Lehtovaara

    2012-12-01

    Full Text Available A broad scientific consensus exists that the global climate is changing. The Earth’s surface temperature could rise significantly over the next few decades, leading to us witnessing an entirely new and unknown planet. Improved energy efficiency, decreasing use of fossil fuels and wide diffusion of various renewable energy sources are among the focal measures to limit global warming to a sustainable level. The objective of this study is to analyse how renewable energy, such as wind power and bioenergy, could be efficiently commercialized. The evaluation is based on a case study and expert analyses exploiting lateral and parallel thinking methods, and group decision support systems tools. The results reveal that some of the generated ideas are ready for implementation to commercialize renewable energy, whereas others still require technical and commercial development and improvements before maturity.

  12. BOOK REVIEW: Case Studies in Knowledge Management

    Directory of Open Access Journals (Sweden)

    Reviewed by Dr. Adnan BOYACI

    2005-10-01

    Full Text Available 161Case Studies in Knowledge ManagementEdited by Murray JennexHersley: PA: Idea Group, 2005, pp. 372, ISBN 1-59140-352-9Reviewed by Dr. Adnan BOYACIAnadolu UniversityEskişehir-TurkeyKnowledge management (KM as a structured system and the way to the effectiveness isrelatively new field for the contemporary organizations functioning in different andcompetitive domain of public and private sectors in terms of getting optimal effectivenessunderlined by the concepts such as quality, productivity…etc. Because of the growingimportance and the popularity of the KM either as a research topic or specialized coursesubject, a crucial need for understanding, conceptualization and implementation of KM asa system has emerged since the mid 1990’s. In this sense, the book contributes criticallyto fill the gap between theory and implementation as a teaching material.This edited book is published by Idea Group Publishing. The book has twenty chaptersdivided into seven sections. In addition to a section of authors’ biography contributing thebook and an index, there is a preface that the basic terms and key concepts underliningthe cases discussed following chapters, which is explained in a schematized way.Besides the editor, total of 47 authors have contributed to the book. These authors arefrom different countries, academic backgrounds, and institutions. Although approximatelyone third of the authors are from USA, the rest of the authors are from Canada, England,Austria, Germany, Australia, New Zealand, Egypt, Bahrain and China. The authorsrepresent a variety of universities, private companies, and military institutions. Most ofthem have strong professional backgrounds, which help them address the issues bothfrom theoretical and practical perspectives. Contributions of authors having differentbackgrounds and institutions enable the book to have very comprehensive spectrum andthis makes the book attractive practically for those working different sectors

  13. STAKEHOLDERS AND APART HOTELS: MULTIPLE CASE STUDY

    Directory of Open Access Journals (Sweden)

    Patrícia Freire Ferreira Oliveira

    2012-09-01

    Full Text Available Means of accommodation involve a wide range of social actors and agents, as well as different business models. Management strategies in this sector have been increasingly important for long-term sustainability and competitiveness of business organizations. This study aims to analyze the interactions between apart-hotels and their stakeholders to foster an improvement of services provided, aligning the interface of strategic management from the point of view of managers and their key stakeholders. It is an exploratory study, with qualitative chacter, along with multiple case studies of the following establishments: Travel Inn, Hotels Slaviero and Etoile george v. Brazilian enterprises, which manage lodging facilities with apart-hotel concepts, combining features that enable comparative analysis of the study. For conceptual understanding, this study was based on literature about stakeholders, taking the work of Freeman (1984 and Freeman et al (2010 as main references. The research was conducted through semi-structured interviews with managers of lodging facilities and their key stakeholders and through direct observation and documentation. We found that not all groups of influence are considered in the planning of service flats. However, the organizations surveyed indicated that the market has realized the importance of the groups that exert influence and are influenced by their goals, and are therefore increasingly alert for integration of such groups in their strategic planning.

  14. Study on Case-Based Fixture Design

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Fixture is an important manufacturing activity. A fixture design system based on case-based reasoning (CBR) is proposed in this paper. A new method of case representation on the basis of fixture function is presented, where the case representation is constituted of workpiece knowledge, processing feature knowledge, and fixture feature knowledge. Running the prototype system shows that the knowledge representation method, using cases, is a better way to transform and explain the design knowledge.

  15. Phosphorylation of plastoglobular proteins in Arabidopsis thaliana.

    Science.gov (United States)

    Lohscheider, Jens N; Friso, Giulia; van Wijk, Klaas J

    2016-06-01

    Plastoglobules (PGs) are plastid lipid-protein particles with a small specialized proteome and metabolome. Among the 30 core PG proteins are six proteins of the ancient ABC1 atypical kinase (ABC1K) family and their locations in an Arabidopsis mRNA-based co-expression network suggested central regulatory roles. To identify candidate ABC1K targets and a possible ABC1K hierarchical phosphorylation network within the chloroplast PG proteome, we searched Arabidopsis phosphoproteomics data from publicly available sources. Evaluation of underlying spectra and/or associated information was challenging for a variety of reasons, but supported pSer sites and a few pThr sites in nine PG proteins, including five FIBRILLINS. PG phosphorylation motifs are discussed in the context of possible responsible kinases. The challenges of collection and evaluation of published Arabidopsis phosphorylation data are discussed, illustrating the importance of deposition of all mass spectrometry data in well-organized repositories such as PRIDE and ProteomeXchange. This study provides a starting point for experimental testing of phosho-sites in PG proteins and also suggests that phosphoproteomics studies specifically designed toward the PG proteome and its ABC1K are needed to understand phosphorylation networks in these specialized particles. PMID:26962209

  16. Logistics opportunity costs: A mining case study

    Directory of Open Access Journals (Sweden)

    Leani van Jaarsveld

    2013-05-01

    Full Text Available This study highlighted the importance of determining the impact that an ineffective mode of transport has on a firm’s transportation model and costs. The main focus of this study was to determine the logistics opportunity costs of using road transport within a mining firm. A case study approach was followed, as the investigation aimed to analyse a complex problem experienced by one company and present it in an easily understandable format. From the results of this study, it was apparent that the logistics opportunity costs associated with the mode of transport was substantial. This highlighted the need for firms to revise their choice of transport mode on a regular basis, as it has a major impact not only on their transportation costs, but also on their inventory holding and carbon emissions. The results also have implications for South Africa’s only freight railway, Transnet Freight Rail, which should not only focus on expanding its existing capacity, but also on improving its customer service delivery whilst containing tariff increases.

  17. Obsessional Slowness in College Students: Case Studies

    Science.gov (United States)

    Johnson, Aleta

    2014-01-01

    Cases of obsessional slowness, a variant of obsessive compulsive disorder, have been documented in case literature regarding relatively low functioning populations. However, obsessional slowness can also present in higher functioning populations, including college and graduate students, as illustrated here by three case examples from a competitive…

  18. The virtual information: a case study

    Directory of Open Access Journals (Sweden)

    Ginevra Gravili

    2012-09-01

    Full Text Available In todays economics, the fact that information is a major factor of production and of increasing importance as a source of competitive advantage is a generally accepted truism. The trend towards global markets has strongly impacted the competitive situation of many enterprises. Never has the economic environment been subject to so many drastic and rapid changes. This put new weight factors on the requirements for design of business process. This paper explores the case of an Italian legal office that has studied more and more innovative solutions both to satisfy the demands of the clienteles and to oppose the action of the new competitors. Comparing classic models and the theories of Porter with the characteristics and needs of new economy, it shows as the ability to possess, to easily have access, to creatively use of information constitutes one of the more strategic sources of the competitive advantage.

  19. Telepractice for pediatric Dysphagia: a case study.

    Science.gov (United States)

    Malandraki, Georgia A; Roth, Melissa; Sheppard, Justine Joan

    2014-01-01

    A closed-ended intensive pediatric swallowing telepractice program was developed and piloted in one pediatric patient with Opitz BBB/G and Asperger's Syndromes, oropharyngeal dysphagia and aerophagia. The present study is a case report. Outcome variables included behavioral, swallowing and quality of life variables, and were assessed at baseline and at the end of the four-week program. Selective variables were also assessed at a follow-up family interview four weeks post program completion. Over the four-week intervention period, the patient demonstrated substantial improvements in: oral acceptance of eating-related objects and a variety of foods (behavioral variable), timing of voluntary saliva swallows and aerophagia levels (swallowing variables) and quality of life. Follow-up interview analysis showed that most skills were retained or improved one-month post intervention. This intensive telepractice program proved to be feasible and effective for this pediatric patient with dysphagia. PMID:25945217

  20. Telepractice for Pediatric Dysphagia: A Case Study

    Directory of Open Access Journals (Sweden)

    Georgia A. Malandraki

    2014-09-01

    Full Text Available A closed-ended intensive pediatric swallowing telepractice program was developed and piloted in one pediatric patient with Opitz BBB/G and Asperger’s Syndromes, oropharyngeal dysphagia and aerophagia. The present study is a case report. Outcome variables included behavioral, swallowing and quality of life variables, and were assessed at baseline and at the end of the four-week program. Selective variables were also assessed at a follow-up family interview four weeks post program completion. Over the four-week intervention period, the patient demonstrated substantial improvements in: oral acceptance of eating-related objects and a variety of foods (behavioral variable, timing of voluntary saliva swallows and aerophagia levels (swallowing variables and quality of life. Follow-up interview analysis showed that most skills were retained or improved one-month post intervention. This intensive telepractice program proved to be feasible and effective for this pediatric patient with dysphagia.

  1. Understanding Support - lessons from a case study

    Directory of Open Access Journals (Sweden)

    Chris Sauer

    1993-11-01

    Full Text Available Support from top management and others is agreed to be an important factor in information systems success and failure, but little is written about how it has its effect and how it might be managed to a project's advantage. A recently developed conceptual framework is described. It covers the nature and forms of support, the way support affects project outcomes, the bases on which support is provided, and the strategies by which support may be managed. The framework is used to analyse a case study in several stages. At the end of the analysis of each stage, the framework's utility is assessed in terms of its explanatory value and the practical advice it suggests. Areas for further research are identified.

  2. Unmasking Cleckley's psychopath: assessing historical case studies.

    Science.gov (United States)

    DeShong, Hilary L; Helle, Ashley C; Mullins-Sweatt, Stephanie N

    2016-05-01

    The current study investigated original case descriptions of psychopathy (Cleckley, 1941) in relation to current conceptualizations and general personality traits. Attorneys, forensic psychologists and clinical faculty members completed ratings of psychopathy and personality after reading vignettes based on Cleckley's descriptions of a psychopath. The results suggest that professionals' ratings are consistent with current conceptualizations of psychopathy. Furthermore, the five-factor model (FFM) personality traits of the vignettes aligned with the current literature on the FFM and psychopathy (i.e. low neuroticism, conscientiousness and agreeableness). The results further supported that a general trait model, like the FFM, may be well suited to describe the underlying personality traits of psychopathy. Gender differences were also examined. PMID:26931520

  3. Case studies of attacks on communication networks

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Sin Bok; Han, Eon Suk [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1996-06-15

    Recently, as the computer hardware and communications are developed, the data exchange through inter-networking has been highlighted and the data is being recognized as a great asset. Most of the organizations, businesses and enterprises are open to the external world-computer communication networks, attention must be focused on the securities of the information infrastructure. A government organization has been developing 'Circuits Analyzers', and 'Hacker-Tracking Program' and is struggling to track down sneakers. In this report, we analyze the contents of the cases where the communication network has been invaded, from the past up until now in Korea. This report also contains the result of a study on E-mail security, for the protection of KAERI Integrated Management Information System under which utilizes the CALS concepts and web services. (Author)

  4. Case studies in outcome-based education.

    Science.gov (United States)

    Davis, Margery H; Amin, Zubair; Grande, Joseph P; O'Neill, Angela E; Pawlina, Wojciech; Viggiano, Thomas R; Zuberi, Rukhsana

    2007-09-01

    Outcome-based education is one of the most significant global developments in medical education in recent years. This paper presents four case studies of outcome-based education from medical schools in different parts of the world; Scotland; USA; Pakistan; and Singapore. The outcome-based curricula have either been in place for some time, are evolving or are at the planning proposal stage. The outcomes, change process and implementation of the outcome-based approach are described. Variation in the extent to which each medical school has implemented outcome-based education is discussed and key points for successful implementation are highlighted. This paper is based on the pre-conference symposium "outcome-based curricula: global perspectives" presented by the authors at the 4th Asia Pacific Medical Education Conference (APMEC) in Singapore, 8-11 February, 2007. PMID:18236260

  5. Robust control systems theory and case studies

    CERN Document Server

    Mackenroth, Uwe

    2004-01-01

    "Robust Control Systems" gives a self-contained introduction to modern Control Theory. It thus adds a textbook to the existing research-oriented literature on Robust Control. The author lays emphasis on the modern aspects of the design of controllers with prescribed performance and robustness properties. Different to the classical engineering approach, a rigorous mathematical treatment is essential for the full understanding and applicability of the modern methods such as H2 or H8 control or methods based on the structured singular value µ. Nevertheless, no prior knowledge of Control Theory is required as the classical fundamentals are introduced within the first few chapters. Subsequently a large part of the text provides elementary examples and industrial case studies, which are developed in full detail to show how modern methods can be applied to advanced problems. They make intensive use of MATLAB, especially the Control Systems Toolbox and the µ-Analysis and Synthesis Toolbox.

  6. Automated cardiopulmonary resuscitation: a case study.

    Science.gov (United States)

    Spiro, Jon; Theodosiou, Maria; Doshi, Sagar

    2014-02-01

    Rates of survival after cardiac arrest are low and correlate with the quality of cardiopulmonary resuscitation (CPR). Devices that deliver automated CPR (A-CPR) can provide sustained and effective chest compressions, which are especially useful during patient transfer and while simultaneous invasive procedures are being performed. The use of such devices can also release members of resuscitation teams for other work. This article presents a case study involving a man with acute myocardial infarction complicated by cardiogenic shock and pulmonary oedema. It describes how ED nursing and medical teams worked together to deliver A-CPR, discusses the use of A-CPR devices in a tertiary cardiac centre, and highlights the advantages of using such devices.

  7. Unraveling phonological conspiracies: A case study.

    Science.gov (United States)

    Dinnsen, Daniel A; Gierut, Judith A; Morrisette, Michele L; Rose, Darcy E

    2014-01-01

    This paper focuses on three seemingly unrelated error patterns in the sound system of a child with a phonological delay, Child 218 (male, age 4 years 6 months) and ascribes those error patterns to a larger conspiracy to eliminate fricatives from the phonetic inventory. Employing Optimality Theory for its advantages in characterizing conspiracies, our analysis offers a unified account of the observed repairs. The contextual restrictions on those repairs are, moreover, attributed to early developmental prominence effects, which are independently manifested in another error pattern involving rhotic consonants. Comparisons are made with a published case study involving a different implementation of the same conspiracy, the intent being to disambiguate the force behind certain error patterns. The clinical implications of the account are also considered. PMID:25000372

  8. A case study in pathway knowledgebase verification

    Directory of Open Access Journals (Sweden)

    Shah Nigam H

    2006-04-01

    Full Text Available Abstract Background Biological databases and pathway knowledgebases are proliferating rapidly. We are developing software tools for computer-aided hypothesis design and evaluation, and we would like our tools to take advantage of the information stored in these repositories. But before we can reliably use a pathway knowledgebase as a data source, we need to proofread it to ensure that it can fully support computer-aided information integration and inference. Results We design a series of logical tests to detect potential problems we might encounter using a particular knowledgebase, the Reactome database, with a particular computer-aided hypothesis evaluation tool, HyBrow. We develop an explicit formal language from the language implicit in the Reactome data format and specify a logic to evaluate models expressed using this language. We use the formalism of finite model theory in this work. We then use this logic to formulate tests for desirable properties (such as completeness, consistency, and well-formedness for pathways stored in Reactome. We apply these tests to the publicly available Reactome releases (releases 10 through 14 and compare the results, which highlight Reactome's steady improvement in terms of decreasing inconsistencies. We also investigate and discuss Reactome's potential for supporting computer-aided inference tools. Conclusion The case study described in this work demonstrates that it is possible to use our model theory based approach to identify problems one might encounter using a knowledgebase to support hypothesis evaluation tools. The methodology we use is general and is in no way restricted to the specific knowledgebase employed in this case study. Future application of this methodology will enable us to compare pathway resources with respect to the generic properties such resources will need to possess if they are to support automated reasoning.

  9. Use of the foot-and-mouth disease virus 2A peptide co-expression system to study intracellular protein trafficking in Arabidopsis.

    Directory of Open Access Journals (Sweden)

    Stefan Burén

    Full Text Available BACKGROUND: A tool for stoichiometric co-expression of effector and target proteins to study intracellular protein trafficking processes has been provided by the so called 2A peptide technology. In this system, the 16-20 amino acid 2A peptide from RNA viruses allows synthesis of multiple gene products from single transcripts. However, so far the use of the 2A technology in plant systems has been limited. METHODOLOGY/PRINCIPAL FINDINGS: The aim of this work was to assess the suitability of the 2A peptide technology to study the effects exerted by dominant mutant forms of three small GTPase proteins, RABD2a, SAR1, and ARF1 on intracellular protein trafficking in plant cells. Special emphasis was given to CAH1 protein from Arabidopsis, which is trafficking to the chloroplast via a poorly characterized endoplasmic reticulum-to-Golgi pathway. Dominant negative mutants for these GTPases were co-expressed with fluorescent marker proteins as polyproteins separated by a 20 residue self-cleaving 2A peptide. Cleavage efficiency analysis of the generated polyproteins showed that functionality of the 2A peptide was influenced by several factors. This enabled us to design constructs with greatly increased cleavage efficiency compared to previous studies. The dominant negative GTPase variants resulting from cleavage of these 2A peptide constructs were found to be stable and active, and were successfully used to study the inhibitory effect on trafficking of the N-glycosylated CAH1 protein through the endomembrane system. CONCLUSIONS/SIGNIFICANCE: We demonstrate that the 2A peptide is a suitable tool when studying plant intracellular protein trafficking and that transient protoplast and in planta expression of mutant forms of SAR1 and RABD2a disrupts CAH1 trafficking. Similarly, expression of dominant ARF1 mutants also caused inhibition of CAH1 trafficking to a different extent. These results indicate that early trafficking of the plastid glycoprotein CAH1

  10. Numerical and structural chromosome aberrations in cauliflower (Brassica oleracea var. botrytis) and Arabidopsis thaliana

    OpenAIRE

    Ji, X.

    2014-01-01

    Numerical and structural chromosome aberrations in cauliflower (Brassica oleracea var. botrytis) and Arabidopsis thaliana. I studied numerical and structural chromosome aberrations in cauliflower (Brassica oleracea var. botrytis) and Arabidopsis thaliana. The large genomic changes are important for gene balance control, gene expression and regulation, and may affect the plant’s phenotype. Moreover, chromosome changes, in particular polyploidy, inversions and translocations play a signif...

  11. Transgenic Arabidopsis Gene Expression System

    Science.gov (United States)

    Ferl, Robert; Paul, Anna-Lisa

    2009-01-01

    The Transgenic Arabidopsis Gene Expression System (TAGES) investigation is one in a pair of investigations that use the Advanced Biological Research System (ABRS) facility. TAGES uses Arabidopsis thaliana, thale cress, with sensor promoter-reporter gene constructs that render the plants as biomonitors (an organism used to determine the quality of the surrounding environment) of their environment using real-time nondestructive Green Fluorescent Protein (GFP) imagery and traditional postflight analyses.

  12. Industrialization: Different Approaches and Case Studies Industrialization: Different Approaches and Case Studies

    OpenAIRE

    Keith Griffin

    1987-01-01

    Industrialization: Different Approaches and Case Studies This paper enquires whether an industrialisation policy designed by the state might be successful in achieving industrialisation and development in the third world. Three common approaches to industrialisation are analysed in terms of their structural features and consequences: import substitution, capital goods sector promotion, and manufacturing export promotion. Associating these strategies to Brazil, India and South Korea, respectiv...

  13. Case studies on age-management in organisations: report on organisational case studies

    NARCIS (Netherlands)

    Punte, E.; Conen, W.S.; Schippers, J.; Henkens, C.J.I.M.

    2011-01-01

    The acquisition of case studies was thwarted by the economic crisis and the feeling of being ‘over-researched’ by potential organisations. Although organisations in some sectors (e.g. chemical manufacturing) reported the worst part of the economic crisis was behind, many organisations indicated gett

  14. Case Study: The Mystery of the Seven Deaths--A Case Study in Cellular Respiration

    Science.gov (United States)

    Gazdik, Michaela

    2014-01-01

    Cellular respiration, the central component of cellular metabolism, can be a difficult concept for many students to fully understand. In this interrupted, problem-based case study, students explore the purpose of cellular respiration as they play the role of medical examiner, analyzing autopsy evidence to determine the mysterious cause of death…

  15. A multifaceted study of stigma/style cysteine-rich adhesin (SCA)-like Arabidopsis lipid transfer proteins (LTPs) suggests diversified roles for these LTPs in plant growth and reproduction

    OpenAIRE

    Chae, Keun; Gonong, Benedict J.; Kim, Seung-Chul; Kieslich, Chris A.; Morikis, Dimitrios; Balasubramanian, Shruthi; Lord, Elizabeth M

    2010-01-01

    Lily stigma/style cysteine-rich adhesin (SCA), a plant lipid transfer protein (LTP) which is secreted into the extracellular matrix, functions in pollen tube guidance in fertilization. A gain-of-function mutant (ltp5-1) for Arabidopsis LTP5, an SCA-like molecule, was recently shown to display defects in sexual reproduction. In the current study, it is reported that ltp5-1 plants have dwarfed primary shoots, delayed hypocotyl elongation, various abnormal tissue fusions, and display multibranch...

  16. Trichoderma volatiles effecting Arabidopsis

    DEFF Research Database (Denmark)

    Ramadan, Metwaly; Gigolashvili, Tamara; Grosskinsky, Dominik Kilian;

    2015-01-01

    Trichoderma species are present in many ecosystems and some strains have the ability to reduce the severity of plant diseases by activating various defense pathways via specific biologically active signaling molecules. Hence we investigated the effects of low molecular weight volatile compounds...... of Trichoderma asperellum IsmT5 on Arabidopsis thaliana. During co-cultivation of T. asperellum IsmT5 without physical contact to A. thaliana we observed smaller but vital and robust plants. The exposed plants exhibit increased trichome numbers, accumulation of defense-related compounds such as H2O2, anthocyanin......, camalexin, and increased expression of defense-related genes. We conclude that A. thaliana perceives the Trichoderma volatiles as stress compounds and subsequently initiates multilayered adaptations including activation of signaling cascades to withstand this environmental influence. The prominent headspace...

  17. Anorexia in the Adolescence - case study

    Directory of Open Access Journals (Sweden)

    Almeida de Paiva, Maria O

    2010-07-01

    Full Text Available Eating disorders lead to special biological and psychological states. The result of the total lack of food is treated in a distinct way by anorexia. Nutritionists have thus had difficulty in coming to an agreement on the best therapy to prevent such disorders. First it is essential to understand which treatment aims are and then to attempt to know how the several treatment models used nowadays can reach those aims. Someone who suffers from eating disorders, together with an inner deformation, suffers from too much sensitiveness. In order to solve these problems, one needs a change in the relationship with oneself, with the others and with the world. This study presents a teenager’s case study – Anorexia. Is, in fact, a problem that society faces and can’t ignore. Many youngsters have already died and others are following their steps. But there are also those ones that succeeded in overcoming the problem and now are reporting their stories.

  18. Odontoma: a retrospective study of 73 cases

    Energy Technology Data Exchange (ETDEWEB)

    An, Seo Young; An, Chang Hyeon; Choi, Karp Shik [School of Dentistry, Kyungpook National University, Daegu (Korea, Republic of)

    2012-06-15

    The purpose of the present study was to retrospectively evaluate the clinical findings and treatment results for impacted permanent teeth associated with odontomas. We retrospectively investigated 73 odontomas in 72 patients who visited Kyungpook National University Dental Hospital from April 2004 through November 2011. The study was performed using medical records, panoramic radiographs, and pathological reports. Data gathered included age, gender, location, chief complaints, effects on dentition, and treatment of odontoma and the impacted tooth associated with odontoma. Most compound odontomas (46.7%) were found in the second decade and complex odontomas were not related to age. Odontomas showed no gender predilection. Fifty-five cases (75.3%) of odontomas were detected on routine dental radiographs. Sixty percent of compound odontomas occurred in the canine area and 57.1% of complex odontomas in the molar areas. Impaction of permanent teeth (61.6%) was the most common complication on the adjacent teeth. Most odontomas (84.9%) were removed surgically and impacted permanent teeth were managed by surgical removal (53.2%), orthodontic treatment (25.5%), or surgical repositioning (6.4%). There was a statistically significant relation between age and preservation of the impacted permanent teeth associated with odontomas (p<0.01). Early detection and treatment of odontomas increase the possibility of preservation of the impacted tooth. Therefore, it would be suggested that periodic panoramic examination during the first and second decade of life might be beneficial for the early detection and better prognosis of odontomas.

  19. Tactile Astronomy - a Portuguese case study

    Science.gov (United States)

    Canas, L.; Alves, F.; Correia, A.

    2012-09-01

    Although astronomy plays an important role in the most various outreach initiatives, as well as school science curricula, due to its strong visual component in knowledge acquisition, astronomy subjects are not entirely well addressed and accessed by visually impaired students and/or general public. This stresses the need of more tactile material production, still very scarce in an educational context whether formal or informal. This is a case study activity developed based on different schematic tactile images of several objects present in our solar system. These images in relief, highlight, through touch, several relevant features present in the different astronomical objects studied. The scientific knowledge is apprehended through the use of a tactile key, complemented with additional information. Through proper hands-on activities implementation and careful analysis of the outcome, the adapted images associated with an explanatory key prove to be a valuable resource in tactile astronomy domain. Here we describe the process of implementing such initiative near visually impaired students. The struggles and challenges perceived by all involved and the enrichment experience of engaging astronomy with visually impaired audiences, broadening horizons in an overall experience accessible to all.

  20. Go with the flow: A case study

    Energy Technology Data Exchange (ETDEWEB)

    Moran, J.A. [Alfred Hospital, Prahran, VIC (Australia)

    1998-03-01

    Full text: A 55-year-old female presented to the Alfred Emergency Department semi-conscious with frank rectal bleeding requiring blood volume replacement. Labelled red blood cell (RBC) scintigraphy was requested in order to locate the site of bleeding. In vitro labelling of 3 mL of patient``s blood was performed (PYP as a diluted tinning agent and 1 GBq of freshly eluted {sup 99}mTc) and suspended red cells were injected. Using a GE Starcam system with high resolution collimation, images were acquired for 30 seconds (2 s per frame) and thereafter continuously for 1. 5 hours (30 s per frame). During imaging, patient history became available revealing portal hypertension, oesophageal and anal varices due to myelofibrosis and previous cholecystectomy. Initial flow images showed bizarre abdominal collateral vessels. Accumulation of labelled RBC over 1.5 hours in the right upper quadrant indicated the hepatic flexure as the site of bleeding. The initial flow study showing major porto-systemic collateral vessels indicated that therapeutic embolisation via angiography would be life threatening. The patient underwent emergency hemicolectomy and has been bleed-free to date. In this case, delayed RBC scintigraphy accurately located the haemorrhage site. However, the initial flow study demonstrating major vessel collateral flow was crucial in contraindicating angiographic embolisation. Surgery was then the only therapeutic option.

  1. Antineutrino reactor safeguards - a case study

    CERN Document Server

    Christensen, Eric; Jaffke, Patrick

    2013-01-01

    Antineutrinos have been proposed as a means of reactor safeguards for more than 30 years and there has been impressive experimental progress in neutrino detection. In this paper we conduct, for the first time, a case study of the application of antineutrino safeguards to a real-world scenario - the North Korean nuclear crisis in 1994. We derive detection limits to a partial or full core discharge in 1989 based on actual IAEA safeguards access and find that two independent methods would have yielded positive evidence for a second core with very high confidence. To generalize our results, we provide detailed estimates for the sensitivity to the plutonium content of various types of reactors, including most types of plutonium production reactors, based on detailed reactor simulations. A key finding of this study is that a wide class of reactors with a thermal power of less than 0.1-1 GWth can be safeguarded achieving IAEA goals for quantitative sensitivity and timeliness with detectors right outside the reactor ...

  2. Studies on Differential Nuclear Translocation Mechanism and Assembly of the Three Subunits of the Arabidopsis thaliana Transcription Factor NF-Y

    Institute of Scientific and Technical Information of China (English)

    Dieter Hackenberg; Yanfang Wu; Andrea Voigt; Robert Adams; Peter Schramm; Bernhard Grimm

    2012-01-01

    The eukaryotic transcription factor NF-Y consists of three subunits(A,B,and C),which are encoded in Arabidopsis thaliana in multigene families consisting of 10,13,and 13 genes,respectively.In principle,all potential combinations of the subunits are possible for the assembly of the heterotrimeric complex.We aimed at assessing the probability of each subunit to participate in the assembly of NF-Y.The evaluation of physical interactions among all members of the NF-Y subunit families indicate a strong requirement for NF-YB/NF-YC heterodimerization before the entire complex can be accomplished.By means of a modified yeast two-hybrid system assembly of all three subunits to a heterotrimeric complex was demonstrated.Using GFP fusion constructs,NF-YA and NF-YC localization in the nucleus was demonstrated,while NFYB is solely imported into the nucleus as a NF-YC-associated heterodimer NF-YC.This piggyback transport of the two Arabidopsis subunits differs from the import of the NF-Y heterotrimer of heterotrophic organisms.Based on a peptide structure model of the histone-fold-motifs,disulfide bonding among intramolecular conserved cysteine residues of NF-YB,which is responsible for the redox-regulated assembly of NF-YB and NF-YC in human and Aspergillus nidulans,can be excluded for Arabidopsis NF-YB.

  3. Guidelines for Conducting Positivist Case Study Research in Information Systems

    Directory of Open Access Journals (Sweden)

    Graeme Shanks

    2002-11-01

    Full Text Available The case study research approach is widely used in a number of different ways within the information systems community. This paper focuses on positivist, deductive case study research in information systems. It provides clear definitions of important concepts in positivist case study research and illustrates these with an example research study. A critical analysis of the conduct and outcomes of two recently published positivist case studies is reported. One is a multiple case study that validated concepts in a framework for viewpoint development in requirements definition. The other is a single case study that examined the role of social enablers in enterprise resource planning systems implementation. A number of guidelines for successfully undertaking positivist case study research are identified including developing a clear understanding of key concepts and assumptions within the positivist paradigm; providing clear and unambiguous definitions of the units and interactions when using any theory; carefully defining the boundary of the theory used in the case study; using hypotheses rather than propositions in the empirical testing of theory; using fuzzy or probabilistic propositions in recognising that reality can never be perfectly known; selecting case studies carefully, particularly single case studies; and recognising that generalisation from positivist, single case studies is inherently different from generalisation from single experiments. When properly undertaken, positivist, deductive case study research is a valuable research approach for information systems researchers, particularly when used within pluralist research programs that use a number of different research approaches from different paradigms.

  4. Teaching microbiological food safety through case studies

    Directory of Open Access Journals (Sweden)

    Florence Dubois-Brissonnet

    2015-10-01

    Full Text Available Higher education students usually ask for more training based on case studies. This was addressed by designing a specific food safety module (24 hours in which students were shown how to predict microbiological risks in food products i.e. they were asked to determine product shelf-life according to product formulation, preservation methods and consumption habits using predictive microbiology tools. Working groups of four students first identified the main microbiological hazards associated with a specific product. To perform this task, they were given several documents including guides for good hygiene practices, reviews on microbiological hazards in the food sector, flow sheets, etc…  After three-hours of work, the working groups prepared and gave an oral presentation in front of their classmates and professors. This raised comments and discussion that allowed students to adjust their conclusions before beginning the next step of their work. This second step consisted in the evaluation of the safety risk associated with the two major microbiological hazards of the product studied, using predictive microbiology. Students then attended a general lecture on the different tools of predictive microbiology and tutorials (6 hours that made them familiar with the modelling of bacterial growth or inactivation. They applied these tools (9 hours to predict the shelf-life of the studied product according to various scenarios of preservation (refrigeration, water activity, concentration of salt or acid, modified atmosphere, etc… and/or consumption procedures (cooking. The module was concluded by oral presentations of each working group and included student evaluation (3 hours.

  5. Case Study Research in Software Engineering Guidelines and Examples

    CERN Document Server

    Runeson, Per; Rainer, Austen; Regnell, Bjorn

    2012-01-01

    Based on their own experiences of in-depth case studies of software projects in international corporations, in this book the authors present detailed practical guidelines on the preparation, conduct, design and reporting of case studies of software engineering.  This is the first software engineering specific book on the case study research method.

  6. STUDY OF MATERNAL AND PERINATAL OUTCOME IN REFERRED OBSTETRICS CASES

    OpenAIRE

    Umesh; Alka Murlidhar

    2015-01-01

    OBJECTIVE: To review the referred obstetric cases for reason of referral and to study the maternal and perinatal outcome. DESIGN: Prospective Observational study . STUDY POPULATION: 380 cases referred from periphery to tertiary care institute in one year duration. METHODS: INCLUSION C RITERIA : All referred ANC cases to our tertiary care i...

  7. The Undergraduate Case Research Study Model

    Science.gov (United States)

    Vega, Gina

    2010-01-01

    Student-written cases are powerful pedagogical tools that can lead to improved understanding of business situations, more informed analysis, emphasis on reflection, and clearer expository writing, all of which are critical skills for business students. Cases provide an opportunity for students to enjoy an active learning experience and derive the…

  8. Case Study: Camptocormia, a Rare Conversion Disorder.

    Science.gov (United States)

    Rajmohan, Velayudhan; Thomas, Biju; Sreekumar, Kumaran

    2004-01-01

    Camptocormia is a condition characterized by severe frontal flexion of the spinal cord and knees, with passive drooping of both arms. It occurs as a form of conversion disorder. Some cases are associated with behavioral problems. A case of camptocormia of 2-year duration in a south Indian adolescent girl with oppositional defiant disorder and…

  9. Jazz improvisers' shared understanding: a case study.

    Science.gov (United States)

    Schober, Michael F; Spiro, Neta

    2014-01-01

    To what extent and in what arenas do collaborating musicians need to understand what they are doing in the same way? Two experienced jazz musicians who had never previously played together played three improvisations on a jazz standard ("It Could Happen to You") on either side of a visual barrier. They were then immediately interviewed separately about the performances, their musical intentions, and their judgments of their partner's musical intentions, both from memory and prompted with the audiorecordings of the performances. Statements from both (audiorecorded) interviews as well as statements from an expert listener were extracted and anonymized. Two months later, the performers listened to the recordings and rated the extent to which they endorsed each statement. Performers endorsed statements they themselves had generated more often than statements by their performing partner and the expert listener; their overall level of agreement with each other was greater than chance but moderate to low, with disagreements about the quality of one of the performances and about who was responsible for it. The quality of the performances combined with the disparities in agreement suggest that, at least in this case study, fully shared understanding of what happened is not essential for successful improvisation. The fact that the performers endorsed an expert listener's statements more than their partner's argues against a simple notion that performers' interpretations are always privileged relative to an outsider's.

  10. Jazz improvisers’ shared understanding: A case study

    Directory of Open Access Journals (Sweden)

    Michael F. Schober

    2014-08-01

    Full Text Available To what extent and in what arenas do collaborating musicians need to understand what they are doing in the same way? Two experienced jazz musicians who had never previously played together played three improvisations on a jazz standard (It Could Happen to You on either side of a visual barrier. They were then immediately interviewed separately about the performances, their musical intentions, and their judgments of their partner’s musical intentions, both from memory and prompted with the audiorecordings of the performances. Statements from both (audiorecorded interviews as well as statements from an expert listener were extracted and anonymized. Two months later, the performers listened to the recordings and rated the extent to which they endorsed each statement. Performers endorsed statements they themselves had generated more often than statements by their performing partner and the expert listener; their overall level of agreement with each other was greater than chance but moderate to low, with disagreements about the quality of one of the performances and about who was responsible for it. The quality of the performances combined with the disparities in agreement suggest that, at least in this case study, fully shared understanding of what happened is not essential for successful improvisation. The fact that the performers endorsed an expert listener’s statements more than their partner’s argues against a simple notion that performers’ interpretations are always privileged relative to an outsider’s.

  11. High Penetration Photovoltaic Case Study Report

    Energy Technology Data Exchange (ETDEWEB)

    Bank, J.; Mather, B.; Keller, J.; Coddington, M.

    2013-01-01

    Technical concerns with integrating higher penetrations of photovoltaic (PV) systems include grid stability, voltage regulation, power quality (voltage rise, sags, flicker, and frequency fluctuations), and protection and coordination. The current utility grid was designed to accommodate power flows from the central generation source to the transmission system and eventually to the distribution feeders. At the distribution level, the system was designed to carry power from the substation toward the load. Renewable distributed generation, particularly solar PV, provides power at the distribution level challenging this classical paradigm. As these resources become more commonplace the nature of the distribution network and its operation is changing to handle power flow in both directions. This report is focused on large PV installations in which penetration is significantly greater than 15% of maximum daytime feeder load. These case studies are intended to demonstrate success stories with integration of large PV plants at the distribution level as well as some of the solutions used by the utility to ensure safe, reliable operation of both the PV system and the distribution network.

  12. Hybrid Risk Management Methodology: A Case Study

    Directory of Open Access Journals (Sweden)

    Jacky Siu-Lun Ting

    2009-10-01

    Full Text Available Risk management is a decision-making process involving considerations of political, social, economic and engineering factors with relevant risk assessments relating to a potential hazard. In the last decade, a number of risk management tools are introduced and employed to manage and minimize the uncertainty and threats realization to the organizations. However, the focus of these methodologies are different; in which companies need to adopt various risk management principles to visualize a full picture of the organizational risk level. Regarding to this, this paper presents a new approach of risk management that integrates Hierarchical Holographic Modeling (HHM, Enterprise Risk Management (ERM and Business Recovery Planning (BCP for identifying and assessing risks as well as managing the consequences of realized residual risks. To illustrate the procedures of the proposed methodology, a logistic company ABC Limited is chosen to serve as a case study Through applying HHM and ERM to investigate and assess the risk, ABC Limited can be better evaluated the potential risks and then took the responsive actions (e.g. BCP to handle the risks and crisis in near future.

  13. VINCRISTINE INDUCED NEUROTOXICITY: STUDY OF 75 CASES

    Directory of Open Access Journals (Sweden)

    M.T. Arzanian

    2009-08-01

    Full Text Available ObjectiveConcern for side-effects of therapy related to treatment of childhood malignancies is becoming an increasingly important topic. In this study, we evaluated extent of vincristine (VCR induced neurotoxicity in a group of children who underwent chemotherapy, with VCR being part of the regimen.Materials & MethodsIn this investigation, for 75 children (54% boys, 46% girls, aged between 1 to 14 (mean 6.5±4.3 years, serial weekly neurological examinations were performed; of the 75, 70 had acute lymphoblastic leukemia and 5 Wilm's tumor. All patients were on a chemotherapy protocol of at least 4 consecutive VCR (1.5mg/m2 injections.ResultsDecreased deep tendons reflexes were seen in the Achilles reflex in 78%, and the patellar reflex in 53% of patients. Muscle weakness was found in 70% of patients, being mild in 76% of them. Four  percent of patients showed severe weakness. Petosis, jaw pain, hoarseness, abdominal pain and constipation were seen in 15%, 6%, 12%, 12% and 12% respectively. Paresthesia was observed in 32 of 52 patients, over 4 years old. No cases of foot drop, urinary retention or facial nerve palsy were seen in this patient group.ConclusionChildren on usual doses of vincristine regimen may have neuropathic side effects but most of these side effects are mild and not troublesome.Key words: Vincristine, neuropathy, neurotoxicity, side effect

  14. Refugee Problem in Europe – Case Studies

    Directory of Open Access Journals (Sweden)

    Esztella Varga

    2015-11-01

    Full Text Available The European refugee problem has grown dramatically in the last few months, putting a considerable amount of pressure on the European countries. Not only are they facing migrants from North Africa, but from the Middle East as well.In March 2011 the Arab Spring has reached Syria, causing a huge number of Syrians to flee their country and seek asylum in Turkey, and possibly going further to the EU. The refugees who fled Syria as well as those who are leaving North Africa (mostly the failed state of Libya are aiming to reach European soil, but Italy, Greece or Turkey is not ready to handle the amount of refugees. The cooperation of the Mediterranean countries and Europe has not been able to slow down the flow of refugees, and the Mediterranean and Aegean seas have become dangerous routes for the desperate migrants who attempt the sea-crossing. In my analysis I would like to highlight the role of the so-called elements of ‘soft power’ in the way of dealing with the refugee problem. According to my hypothesis, the issue can’t be successfully addressed using only the means of the ‘soft power’. No real solution for the crisis has been offered yet, and I would like to give case studies of the different ways of dealing with the problem – inside (Greece, Italy and outside (Turkey of the European Union.

  15. Case study for a vaccine against leishmaniasis.

    Science.gov (United States)

    Alvar, Jorge; Croft, Simon L; Kaye, Paul; Khamesipour, Ali; Sundar, Shyam; Reed, Steven G

    2013-04-18

    Leishmaniasis in many ways offers a unique vaccine case study. Two reasons for this are that leishmaniasis is a disease complex caused by several different species of parasite that are highly related, thus raising the possibility of developing a single vaccine to protect against multiple diseases. Another reason is the demonstration that a leishmaniasis vaccine may be used therapeutically as well as prophylactically. Although there is no registered human leishmaniasis vaccine today, immunization approaches using live or killed organisms, as well as defined vaccine candidates, have demonstrated at least some degree of efficacy in humans to prevent and to treat some forms of leishmaniasis, and there is a vigorous pipeline of candidates in development. Current approaches include using individual or combined antigens of the parasite or of salivary gland extract of the parasites' insect vector, administered with or without formulation in adjuvant. Animal data obtained with several vaccine candidates are promising and some have been or will be entered into clinical testing in the near future. There is sufficient scientific and epidemiological justification to continue to invest in the development of vaccines against leishmaniasis.

  16. Dynamic optimization case studies in DYNOPT tool

    Science.gov (United States)

    Ozana, Stepan; Pies, Martin; Docekal, Tomas

    2016-06-01

    Dynamic programming is typically applied to optimization problems. As the analytical solutions are generally very difficult, chosen software tools are used widely. These software packages are often third-party products bound for standard simulation software tools on the market. As typical examples of such tools, TOMLAB and DYNOPT could be effectively applied for solution of problems of dynamic programming. DYNOPT will be presented in this paper due to its licensing policy (free product under GPL) and simplicity of use. DYNOPT is a set of MATLAB functions for determination of optimal control trajectory by given description of the process, the cost to be minimized, subject to equality and inequality constraints, using orthogonal collocation on finite elements method. The actual optimal control problem is solved by complete parameterization both the control and the state profile vector. It is assumed, that the optimized dynamic model may be described by a set of ordinary differential equations (ODEs) or differential-algebraic equations (DAEs). This collection of functions extends the capability of the MATLAB Optimization Tool-box. The paper will introduce use of DYNOPT in the field of dynamic optimization problems by means of case studies regarding chosen laboratory physical educational models.

  17. Comparative economic analysis: Anaerobic digester case study

    International Nuclear Information System (INIS)

    An economic guide is developed to assess the value of anaerobic digesters used on dairy farms. Two varieties of anaerobic digesters, a conventional mixed-tank mesophilic and an innovative earthen psychrophilic, are comparatively evaluated using a cost-effectiveness index. The two case study examples are also evaluated using three other investment merit statistics: simple payback period, net present value, and internal rate of return. Life-cycle savings are estimated for both varieties, with sensitivities considered for investment risk. The conclusion is that an earthen psychrophilic digester can have a significant economic advantage over a mixed-tank mesophilic digester because of lower capital cost and reduced operation and maintenance expenses. Because of this economic advantage, additional projects are being conducted in North Carolina to increase the rate of biogas utilization. The initial step includes using biogas for milk cooling at the dairy farm where the existing psychrophilic digester is located. Further, a new project is being initiated for electricity production with thermal reclaim at a swine operation

  18. Integrative study of Arabidopsis thaliana metabolomic and transcriptomic data with the interactive MarVis-Graph software

    OpenAIRE

    Manuel Landesfeind; Alexander Kaever; Kirstin Feussner; Corinna Thurow; Christiane Gatz; Ivo Feussner; Peter Meinicke

    2014-01-01

    State of the art high-throughput technologies allow comprehensive experimental studies of organism metabolism and induce the need for a convenient presentation of large heterogeneous datasets. Especially, the combined analysis and visualization of data from different high-throughput technologies remains a key challenge in bioinformatics. We present here the MarVis-Graph software for integrative analysis of metabolic and transcriptomic data. All experimental data is investigated in terms of th...

  19. Evaluations of Regional Competitiveness: Making a Case for Case Studies

    OpenAIRE

    Barkley, David L.

    2008-01-01

    This paper provides an overview of the concepts of regional competitiveness, including definitions, conceptual models, measurements, and the benefits and shortcomings of following a strategy to enhance competitiveness. Next, city-region rankings and indices of competitiveness are reviewed and the usefulness of these studies is summarized. Potential roles for regional scientists for improving (1) evaluations of regional competitiveness and (2) applications of evaluations to regional developmen...

  20. Cases for the Net Generation: An Empirical Examination of Students' Attitude toward Multimedia Case Studies

    Science.gov (United States)

    Sheppard, Michael; Vibert, Conor

    2016-01-01

    Case studies have been an important tool in business, legal, and medical education for generations of students. Traditional text-based cases tend to be self-contained and structured in such a way as to teach a particular concept. The multimedia cases introduced in this study feature unscripted web-hosted video interviews with business owners and…

  1. Case Study: What Makes a Good Case, Revisited: The Survey Monkey Tells All

    Science.gov (United States)

    Herried, Clyde Freeman; Prud'homme-Genereux, Annie; Schiller, Nancy A.; Herreid, Ky F.; Wright, Carolyn

    2016-01-01

    This column provides original articles on innovations in case study teaching, assessment of the method, as well as case studies with teaching notes. In this month's issue the authors provide a more definitive answer to the "What Makes a Good Case?" question based on a just-completed Survey Monkey survey given to NCCSTS teachers.

  2. Bilingual education in Slovakia: A Case Study

    Directory of Open Access Journals (Sweden)

    Silvia Pokrivčáková

    2013-06-01

    Full Text Available Bilingual education is one of the areas in contemporary education that brings out some important controversies (philosophical, conceptual, sociological, political, economical, etc. and thus calls for extensive and intensive debate. Bilingual education in Europe (and here the European Union countries are meant has gained a very different status, due to the general European policy of developing language diversity and promoting “European plurilingualism and multilingualism”. In Slovakia, one of the younger members of the EU, bilingual education became an extraordinarily popular instrument for the fulfilment of this task.  Since the specifically defined topic of bilingual education and its current status in Slovakia has not been studied and systematically reviewed yet, the research presented in this paper was designed as a single-phenomenon revelatory case study investigating seven research areas: reflection of bilingual education in school legislation and state pedagogical documents, purposes of bilingual education in Slovakia, its organization (levels and types of schools, foreign languages incorporated, teachers, structure of bilingual schools curricula, types of bilingual education applied at Slovak bilingual schools, and how bilingual education is both reflected in and saturated by the latest research findings. The conclusions presented in the paper were collected from multiple sources: state curriculum, statistical data published by the Slovak Ministry of Education or its partner institutions, international treaties on establishing and supporting bilingual sections of schools, bilingual schools curricula, interviews with school directors, teachers, and learners, direct observations at bilingual schools, research studies and research reports, etc. In the conclusion, bilingual education in Slovakia is identified as a unique, dynamically developing system which is both significantly shaped by the foreign language education policy promoted by

  3. Mathematical modelling with case studies using Maple and Matlab

    CERN Document Server

    Barnes, B

    2014-01-01

    Introduction to Mathematical ModelingMathematical models An overview of the book Some modeling approaches Modeling for decision makingCompartmental Models Introduction Exponential decay and radioactivity Case study: detecting art forgeries Case study: Pacific rats colonize New Zealand Lake pollution models Case study: Lake Burley Griffin Drug assimilation into the blood Case study: dull, dizzy, or dead? Cascades of compartments First-order linear DEs Equilibrium points and stability Case study: money, money, money makes the world go aroundModels of Single PopulationsExponential growth Density-

  4. Structured Controversy: A Case Study Strategy.

    Science.gov (United States)

    Herreid, Clyde Freeman

    1996-01-01

    Introduces a dynamic form of the case instruction method that involves debate and compromise. Discusses two versions of structured controversy and presents an example of structured controversy that involves the use of DNA fingerprinting in forensic medicine. (JRH)

  5. Sensitive detection and measurement of oligogalacturonides in Arabidopsis

    Directory of Open Access Journals (Sweden)

    Daniela ePontiggia

    2015-04-01

    Full Text Available Oligogalacturonides (OGs are pectin fragments derived from the partial hydrolysis of the plant cell wall pectin; they are elicitors of various defense responses. While their activity is well documented, the detection of OGs produced in planta is still a challenging task.A protocol has been developed for the extraction and analysis of OGs from small samples of Arabidopsis tissues by using fluorescent labelled OGs, which allowed to monitor the efficiency of extraction. An efficient recovery was obtained by using a combination of calcium chelating agents at acidic pH. Off-line coupling of HPAEC with MALDI-TOF-MS or nanoESI-Orbitrap-MS/MS was used for the identification and characterization of oligosaccharides. The protocol was successfully applied to detect OGs by using low amounts (50 mg of Arabidopsis leaves and very low amounts (30 mg of senescent leaves. The protocol was also successfully used to detect OGs in Arabidopsis cell wall material digested with pectinases.The proposed extraction protocol followed by sensitive and high-resolution analysis methods allowed detection of OGs released from the cell wall in Arabidopsis tissues by using minimal sample material. The protocol may be useful to study OG-triggered plant immunity and cell wall remodeling during Arabidopsis growth and development.

  6. TIMWE : Born Global Firm : case study

    OpenAIRE

    Marques, Frederico José Castro Reis

    2013-01-01

    TIMWE is the Portuguese based company chosen to illustrate and serve as background to support the creation of a teaching case in Strategy, exploring the internationalization of a real company and the challenges undertaken by the process of being a born global firm, followed by a Teaching Note that can be used as a tool to help solving the case. TIMWE is a Portuguese owned company, founded in 2002, that offers mobile monetization solutions and services (entertainment, marketing and money) t...

  7. Phyllodes tumor in adolescent. Case study.

    OpenAIRE

    Lidia Torres Aja; Julio Sarmiento Sánchez; María Caridad Rubio Hernández

    2008-01-01

    Presentation of the case of a patient (18 years old) who was assisted in the provincial mastology consultation for a non painful tumor, of sudden growth covering almost all the right breast, without other symptom or sing. After some tests, it was decided to operate. The tumor turned to be benign phyllodes. The relevance of this case lies in the infrequent appearance of this type of tumor, being even the first to be operated in our hospital.

  8. Chromosomal rearrangement in autotetraploid plants of Arabidopsis thaliana.

    Science.gov (United States)

    Weiss, H; Maluszynska, J

    2000-01-01

    Recent development of cytogenetic techniques has facilitated significant progress in Arabidopsis thaliana karyotype studies. Double-target FISH with rRNA genes provides makers that allow individual chromosome in the genome to be distinguished. Those studies have revealed that the number and position of rDNA loci is ecotype-specific. Arabidopsis is believed to be a true diploid (x = 5) with numerous ecotypes (accessions) and only a very few natural polyploid populations reported. Few studies were undertaken to induce polyploidy in Arabidopsis, however none of those gave the cytogenetic characteristics of polyploid plants. Our analysis of chromosome pairing of colchicine-induced autotetraploid Arabidopsis (Wilna ecotype) revealed preferential bivalent pairing in PMCs (pollen mother cells). In order to attempt to explain this phenomenon, first of all more detailed cytogenetic studies of autopolyploid plants have been undertaken. The localization of 45S and 5S rDNA loci in the diploid and autotetraploid plants revealed that Wilna ecotypes belongs to the group of Arabidopsis accessions with only two 5S rDNA loci present in a genome. Furthermore, the rearrangement of 45S rDNA locus in autopolyploid, when compared to the diploid plants of the same ecotype, was revealed. These results are interesting also in the context of the recently emphasised role of polyploidy in plant evolution and speciation. Arabidopsis, despite having small chromosomes, is a good system to study chromosome behaviour in relation to diploidization of autopolyploids and to evaluate the degree of chromosomal rearrangements during this process. PMID:11433970

  9. Superior cross-species reference genes: a blueberry case study.

    Science.gov (United States)

    Die, Jose V; Rowland, Lisa J

    2013-01-01

    The advent of affordable Next Generation Sequencing technologies has had major impact on studies of many crop species, where access to genomic technologies and genome-scale data sets has been extremely limited until now. The recent development of genomic resources in blueberry will enable the application of high throughput gene expression approaches that should relatively quickly increase our understanding of blueberry physiology. These studies, however, require a highly accurate and robust workflow and make necessary the identification of reference genes with high expression stability for correct target gene normalization. To create a set of superior reference genes for blueberry expression analyses, we mined a publicly available transcriptome data set from blueberry for orthologs to a set of Arabidopsis genes that showed the most stable expression in a developmental series. In total, the expression stability of 13 putative reference genes was evaluated by qPCR and a set of new references with high stability values across a developmental series in fruits and floral buds of blueberry were identified. We also demonstrated the need to use at least two, preferably three, reference genes to avoid inconsistencies in results, even when superior reference genes are used. The new references identified here provide a valuable resource for accurate normalization of gene expression in Vaccinium spp. and may be useful for other members of the Ericaceae family as well.

  10. Case Studies In Business Market Research: An Abductive Approach

    OpenAIRE

    DuBois, A.; Gadde, L

    1999-01-01

    Case studies are frequently used in industrial network research. In this paper we discuss the difficulties and opportunities characterizing the case study approach. In particular we deal with single case research aiming at theory generation. For this purpose we suggest an approach based on 'systematic combining' grounded in an 'abductive' logic.

  11. Arabidopsis Hormone Database: a comprehensive genetic and phenotypic information database for plant hormone research in Arabidopsis

    OpenAIRE

    Peng, Zhi-Yu; Zhou, Xin; Li, Linchuan; Yu, Xiangchun; Li, Hongjiang; Jiang, Zhiqiang; Cao, Guangyu; Bai, Mingyi; Wang, Xingchun; Jiang, Caifu; Lu, Haibin; Hou, Xianhui; Qu, Lijia; Wang, Zhiyong; Zuo, Jianru

    2008-01-01

    Plant hormones are small organic molecules that influence almost every aspect of plant growth and development. Genetic and molecular studies have revealed a large number of genes that are involved in responses to numerous plant hormones, including auxin, gibberellin, cytokinin, abscisic acid, ethylene, jasmonic acid, salicylic acid, and brassinosteroid. Here, we develop an Arabidopsis hormone database, which aims to provide a systematic and comprehensive view of genes participating in plant h...

  12. On misunderstandings in connection with case-studies

    DEFF Research Database (Denmark)

    Flyvbjerg, Bent

    2005-01-01

    and concludes with the Kuhnian insight that a scientific discipline without a large number of thoroughly executed case studies is a discipline without systematic production of exemplars, and that a discipline without exemplars is an ineffective one. Social science may be strengthened by the execution......This article examines five common misunderstandings about case-study research: (1) Theoretical knowledge is more valuable than practical knowledge; (2) One cannot generalize from a single case, therefore the single case study cannot contribute to scientific development; (3) The case study is most...... useful for generating hypotheses, while other methods aremore suitable for hypotheses testing and theory building; (4) The case study contains a bias toward verification; and (5) It is often difficult to summarize specific case studies. The article explains and corrects these misunderstandings one by one...

  13. Antenatal stress: An Irish case study.

    LENUS (Irish Health Repository)

    Carolan-Olah, Mary

    2013-05-16

    BACKGROUND:: stress in pregnancy is common and impacts negatively on women, infants and families. A number of factors contribute to high levels of stress in pregnancy, including financial concerns, marital discord, low support systems and low socio-economic status. OBJECTIVES:: the aim of this study was to evaluate stress anxiety levels and depressive symptoms among low risk women in an area in Ireland that was particularly impacted by the 2008 economic crisis. DESIGN:: a quantitative descriptive cross-sectional design was used. Data were collected using the Edinburgh Postnatal Depression Scale (EPDS), the Perceived Stress Scale and the State Trait Anxiety Inventory (STAI). Data was collected at a single time during the second trimester. SETTING:: this paper reports a case study of one maternity service in Ireland. Participants included low risk pregnant women who were attending the hospital clinic for routine antenatal care. RESULTS:: of 150 questionnaires distributed, 74 completed questionnaires were returned indicating a 49.3% return rate. Findings indicated high levels of stress, anxiety and depressive symptomatology among participants. There were no significant difference in mean EPDS score for different age groups (F4,69=2.48, P=0.052), living arrangements (F4,68=0.90, P=0.5) or usual occupation (F4,69=1.45, P=0.2). A score of ≥12 was taken as indicative of probable antenatal depression and 86.5% of participants responded with a score of 12 or above. PSS scores were also high and more than three quarters of respondents scored ≥15 (75.6%) and more than a third had scores ≥20 (35.1%), out of a total score of 40. There was a significant difference in mean PSS score between the different age groups (F4,69=3.60, P=0.010) but not for living arrangements or usual occupation. A STAI score of ≥39 was taken as indicative of antenatal anxiety, and 74.3% of participants responded with a score of 39 or above. There were no significant differences in mean STAI

  14. Studies on five cases of radiation enterocolitis

    Energy Technology Data Exchange (ETDEWEB)

    Yasunaga, Akira; Shibata, Okihiko; Kubo, Hironobu; Tomonari, Kazuhide; Hadama, Tetsuo; Uchida, Yuzou; Shirabe, Joji (Oita Medical Coll. (Japan))

    1990-05-01

    Five patients with radiation enterocolitis who were surgically treated are reported. The 5 patients had received irradiation therapy more than 5,000 rad for ginecologic malignancies. The period for the onset of symptoms of irradiation enteritis ranged from 8 months to 20 years however, 3 of them developed the symptoms within one year after irradiation therapy. Emergency surgery was carried out for bowel obstruction in 3 cases and for intestinal perforation in 2 cases. Bowel resection and primary anastomosis were performed by a one-step approach in 4 of them. Transient colostomy as preventive measure was added in 2 cases. It is very important for the one-step approach to resect the intestine at the healthy part far from the lesion of irradiation enteritis and to add a transient colostomy to prevent anastomolic insufficiency. Furthermore, suture material should be used less tissue reactive one. (author).

  15. Fourier transform-infrared studies on the effects of salt and drought stress on the chemical composition and pro-tein conformation changes in Arabidopsis leaves

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    We examined the changes of chemical composition and protein conformation in Arabidopsis leaves by Fourier transform-infrared (FT-IR) spectrometry Arabidopsis under 50 mmol/L NaCl salt and -0.5 mPa polyethylene glycols 8000 (PEG 8000) drought stress during the early stages of growth.We primarily analyzed the absorption band areas in the 1,745 cm-1 (ester),1,600-1,700 cm-1 (amide I),and 1,100 cm-1 (carbohydrate) changes under salt stress and drought stress within 24 hours.The results showed that ester content declined at the beginning and then increased steadily during 24 hours of drought stress.But under salt stress,it de-clined steadily,and it was about 40 percent of the control after 24 hours.The protein synthesis increased by 25 percent after one hour of salt stress and then reached about 85 percent of the control after 24 hours.Under drought stress,the protein synthesis de-creased and reached aminimal level at the 4-hr time point;it then recovered to the control level at the 24-hr point.The patterns of the accumulation of carbohydrates in the 1,100 cm-1 band areas resembled that of amide I band changes under drought stress and salt stress.Analyzing the ratio A1,627cm-1/A1,658cm-1 under drought stress revealed that the leaves’ entire protein structure maintained a higher-level ordered form than did those under salt stress.Thus our results indicate the existence of different strategies of the Arabidopsis adaptation to salt stress and drought stress.

  16. The use of case studies in teaching undergraduate neuroscience.

    Science.gov (United States)

    Meil, William M

    2007-01-01

    Case studies have been the cornerstone of many discoveries in neurology and continue to be an indispensable source of knowledge. Attaching a name, face, and story to the study of neurological disorders makes them more "real" and memorable. This article describes the value of the case study methodology and its advantages as a pedagogical approach. It also illustrates how the seminal case of H.M. can be used to highlight the advantages and disadvantages of the case study methodology. Three exercises are described for incorporating case studies into neuroscience courses. The first exercise requires students to conduct a literature review regarding their assigned case and then design an experiment to address a lingering question regarding that neurological disorder. Survey results of 90 students provide quantitative and qualitative support for this approach. The vast majority of students indicated this exercise was a valuable learning experience; sparked interest in the topic and in biopsychology; increased their knowledge and stimulated critical thinking. The second exercise discusses how students might conduct their own case studies. The third exercise emphasizes the use of case studies as a platform to examine competing hypotheses regarding neurological conditions and their treatment. A table listing case studies appropriate for undergraduate neuroscience courses is included. Cases are categorized by the type of neurological disorder and notes regarding the nature of and content of each case are provided. PMID:23493154

  17. Capturing Cultural Glossaries: Case-study I *

    Directory of Open Access Journals (Sweden)

    Matete Madiba

    2011-10-01

    Full Text Available

    Abstract: This article is a presentation of a brief cultural glossary of Northern Sotho cooking terms. The glossary is mainly composed of names for utensils and ingredients, and action words for the processes involved in the preparation of cultural dishes. It also contains names of dishes tied to some idiomatic expressions in a way eliciting cultural experiences that can lead to an under-standing of indigenous knowledge systems. The article seeks to explore ways of capturing cultural glossaries to feed into the national dictionary corpora by using a case-study approach to investigate the processes that led to the generation of this specific school-based project. A number of issues that surfaced in this project, can possibly serve as models for the collection of authentic glossaries that can support dictionary making in African languages.

    Keywords: CULTURAL GLOSSARY, INDIGENOUS KNOWLEDGE SYSTEMS, CULTURAL TERMINOLOGY, CORPUS, AUTHENTIC GLOSSARY, CONTEXTUALISATION, MARGIN-ALIZED LANGUAGES, OUTCOMES-BASED EDUCATION, PERFORMANCE INDICATOR, ASSESSMENT CRITERIA, RANGE STATEMENT, TRADITIONAL DISHES, LANGUAGE VAL-ORISATION, SIMULTANEOUS FEEDBACK, COMMUNICATIVE APPROACH, STRUCTURAL APPROACH, METONYMY

    Opsomming: Die totstandbrenging van kulturele woordversamelings: Ge-vallestudie I. Hierdie artikel is 'n aanbieding van 'n kort kulturele woordversameling van Noord-Sothokookterme. Die woordversameling bestaan hoofsaaklik uit die name van gereedskap en bestanddele, en handelingswoorde vir die prosesse betrokke by die voorbereiding van kulturele geregte. Dit bevat ook name van geregte wat verbind is met sekere idiomatiese uitdrukkings wat op 'n manier kulturele ervarings oproep wat kan lei tot die verstaan van inheemse kennisstelsels. Die artikel probeer om maniere te ondersoek waarop kulturele woordversamelings in die nasionale woordeboekkorpusse ingevoer kan word deur 'n gevallestudiebenadering te volg om die prosesse te ondersoek wat tot die

  18. Case studies: Soil mapping using multiple methods

    Science.gov (United States)

    Petersen, Hauke; Wunderlich, Tina; Hagrey, Said A. Al; Rabbel, Wolfgang; Stümpel, Harald

    2010-05-01

    Soil is a non-renewable resource with fundamental functions like filtering (e.g. water), storing (e.g. carbon), transforming (e.g. nutrients) and buffering (e.g. contamination). Degradation of soils is meanwhile not only to scientists a well known fact, also decision makers in politics have accepted this as a serious problem for several environmental aspects. National and international authorities have already worked out preservation and restoration strategies for soil degradation, though it is still work of active research how to put these strategies into real practice. But common to all strategies the description of soil state and dynamics is required as a base step. This includes collecting information from soils with methods ranging from direct soil sampling to remote applications. In an intermediate scale mobile geophysical methods are applied with the advantage of fast working progress but disadvantage of site specific calibration and interpretation issues. In the framework of the iSOIL project we present here some case studies for soil mapping performed using multiple geophysical methods. We will present examples of combined field measurements with EMI-, GPR-, magnetic and gammaspectrometric techniques carried out with the mobile multi-sensor-system of Kiel University (GER). Depending on soil type and actual environmental conditions, different methods show a different quality of information. With application of diverse methods we want to figure out, which methods or combination of methods will give the most reliable information concerning soil state and properties. To investigate the influence of varying material we performed mapping campaigns on field sites with sandy, loamy and loessy soils. Classification of measured or derived attributes show not only the lateral variability but also gives hints to a variation in the vertical distribution of soil material. For all soils of course soil water content can be a critical factor concerning a succesful

  19. DDACE cogeneration systems : 10 case studies

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    DDACE Power Systems are experts in green energy power generation and provide solutions that deal with waste and industrial by-products. The company develops practical energy solutions that address environmental and financial concerns facing both industrial and municipal customers. The following 10 case studies are examples of the installations that DDACE Power Systems have completed in recent years: (1) a combined heat and emergency power installation on the roof of a 19 storey apartment building on Bloor Street in Toronto, Ontario. The cogeneration package provides electricity and heat to the entire building, replacing an old diesel generator, (2) a combined heat and emergency power installation at the Villa Colombo extended care facility in Vaughan, Ontario. The cogeneration system provides heat and power to the building, as well as emergency power, (3) emergency standby power with demand response capabilities at Sobeys Distribution Warehouse in Vaughan, Ontario. The primary purpose of the 2.4 MW low emission, natural gas fuelled emergency standby generator is to provide emergency power to the building in the event of a grid failure, (4) a dual fuel combined heat and power installation at the Queensway Carleton Hospital in Ottawa, Ontario that provides electricity, hot water and steam to all areas of the hospital, (5) a tri-generation installation at the Ontario Police College in Aylmer, Ontario which provides power and heat to the building as well as emergency power in the event of a grid failure. An absorption chiller provides cooling in the summer and an exhaust emission control system reduces NOx emissions, (6) a biomass gasification installation at Nexterra Energy in Kamloops, British Columbia. The 239 kW generator is fueled by synthesis gas, (7) biogas utilization at Fepro Farms in Cobden, Ontario for treatment of the facility's waste products. The biogas plant uses cow manure, as well as fats, oil and grease from restaurants to produce electricity and

  20. Arabidopsis thaliana peroxidase N

    DEFF Research Database (Denmark)

    Mirza, Osman Asghar; Henriksen, A; Ostergaard, L;

    2000-01-01

    The structure of the neutral peroxidase from Arabidopsis thaliana (ATP N) has been determined to a resolution of 1.9 A and a free R value of 20.5%. ATP N has the expected characteristic fold of the class III peroxidases, with a C(alpha) r.m.s.d. of 0.82 A when compared with horseradish peroxidase C...... (HRP C). HRP C is 54% identical to ATP N in sequence. When the structures of four class III plant peroxidases are superimposed, the regions with structural differences are non-randomly distributed; all are located in one half of the molecule. The architecture of the haem pocket of ATP N is very similar...... to that of HRP C, in agreement with the low small-molecule substrate specificity of all class III peroxidases. The structure of ATP N suggests that the pH dependence of the substrate turnover will differ from that of HRP C owing to differences in polarity of the residues in the substrate-access channel. Since...

  1. Olympus Imaging Fraud Scandal: A Case Study

    Science.gov (United States)

    Elam, Dennis; Madrigal, Marion; Jackson, Maura

    2014-01-01

    This case examines the two decade long tobashi scheme by Olympus Imaging Executives to hide $1.7 billion in losses. In the 1980s, a soaring yen and falling dollar caused bottom line income problems for many Japanese companies. Some companies sought to offset the declining revenue with zaiteku, a form of speculative investment. While early…

  2. Tuberculosis of breast (study of 7 cases.

    Directory of Open Access Journals (Sweden)

    Sharma P

    1991-01-01

    Full Text Available Seven cases of tuberculosis of breast are presented. The clinical features were multiple discharging sinuses, lump, ulcer and recurring abscess of breast. Diagnosis relied on histological appearance. Acid fast bacilli being present in only one specimen and positive culture obtained in one patient. Successful treatment combines antituberculous drug therapy with removal of infected breast tissue.

  3. Child Survivor of War: A Case Study

    Science.gov (United States)

    Roysircar, Gargi

    2004-01-01

    This article examines the history of a Bosnian survivor of war living in the U.S. using the extended case method. Clinical issues related to acculturative stress, posttraumatic stress disorder, and identity are analyzed. Suggested treatment includes existential therapy and its cognitive--behavioral applications, didactic education on trauma,…

  4. Supply chain strategy: empirical case study in Europe and Asia:

    OpenAIRE

    Sillanpää, Ilkka; Sillanpää, Sebastian

    2014-01-01

    The purpose of this case study research is to present a literature review of supply chain strategy approaches, develop supply chain strategy framework and to validate a framework in empirical case study. Literature review and case study research are the research methods for this research. This study presents the supply chain strategy framework which merges together business environment, corporate strategy, supply chain demand and supply chain strategy. Research argues that all the different c...

  5. Mucocele - A study of 36 cases

    Directory of Open Access Journals (Sweden)

    Jani Dhaval

    2010-01-01

    Full Text Available Background: Mucocele is one of the most common benign soft tissue tumor present in the oral cavity. They are of two types - one is extravasation and second one is retention type but the majority are extravasation type. Aims: The objective is to determine various factors related to mucocele such as role of trauma due to nearby teeth, recurrence, duration, and to find out whether there is any role of psychological stress which initiates trauma like lip or cheek biting. Materials and Methods: 36 cases of mucocele diagnosed at the Department of the Oral Pathology, Govt. Dental College and Hospital, Ahmedabad, between 2004 and 2008 were reviewed. The clinical data were recorded and histopathologic diagnosis was made. Statistical Analysis Used: Data analysis tool, Microsoft Office Excel 2007. Results: A diagnosis of mucocele was established in 36 cases with male-to-female ratio of 1.77:1. Most common type was extravasation in 30 (83.33% cases. The peak age of occurrence was between 1st and 3rd decade. Lateral side of the lower labial mucosa was the most affected site in 34 (94.44% cases. The history of trauma appeared the major etiological factor seen in 28 (77.77% cases. Conclusion: We conclude that there was male predominance and they were more affected in 2nd and 3rd decade. The lateral side of lower labial mucosa was the commonest site and the trauma due to teeth or lip biting was the major etiological factor for the occurrence of the mucocele. The article highlights role of psychological stress in occurrence of mucocele. The reader should understand the importance of histopathology examination and should try to control the psychological stress in such mucocele patients.

  6. Omics analysis of high-energy Arabidopsis thaliana

    OpenAIRE

    Liang, Chao; 梁超

    2014-01-01

    Arabidopsis thaliana purple acid phosphatase 2 (AtPAP2) is a phosphatase dually targeted to both chloroplasts and mitochondria. Overexpression (OE) of AtPAP2 in Arabidopsis thaliana was reported to speed up plant growth and promote flowering, seed yield and biomass at maturity in a previous study. Under long-day (16 hours light at 22°C / 8 hours dark at 18°C) growth conditions, the leaves of 20-day-old OE lines contained significant higher sucrose and glucose than the wild-type (WT) plants, r...

  7. Delusional parasitosis--study of 3 cases.

    Directory of Open Access Journals (Sweden)

    Hanumantha K

    1994-10-01

    Full Text Available Delusional disorder-somatic (parasitosis type is a rare psychiatric disorder which poses a challenge to diagnostic and therapeutic skills. Pimozide, a highly specific dopamine blocker has shown promising results in the 3 cases illustrated here. These cases were seen over a period of 3 years. All the three patients believed that an insect has entered through the ear and is burrowing tracts/laying multiple eggs. They approached the ENT surgeons or neurosurgeon with a fear that their brain will be invaded. On psychiatric evaluation, no past or present history of major psychiatric illness was found. Premorbid personalities were well adjusted. Only for two patients, acute moderate stressors were detected. Delusions disappeared by the end of 2 wks but therapy was continued for 5 months.

  8. Insider Threat Case Studies at Radiological and Nuclear Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Pope, Noah Gale [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hobbs, Christopher [Centre for Science and Security Studies, London (United Kingdom)

    2015-04-13

    Seven case studies are presented. The cases include thefts of various materials and sabotage. For each case there is an overview of the incident, a timeline, a profile of the perpetrator, and a discussion of the security system failures which allowed the incident to take place.

  9. Communicating Ocean Sciences to Informal Audiences (COSIA): Case Studies

    Science.gov (United States)

    Inverness Research, 2010

    2010-01-01

    The three case studies presented in this paper are descriptive and evaluative in nature, and are designed to describe, explain, and portray in some detail three examples of COSIA partnerships. These cases are context bound; the place-based aspect of these cases is critical to the phenomenon being explored. Consistent with the goal for employing a…

  10. Television Medical Dramas as Case Studies in Biochemistry

    Science.gov (United States)

    Millard, Julie T.

    2009-01-01

    Several case studies from popular television medical dramas are described for use in an undergraduate biochemistry course. These cases, which illustrate fundamental principles of biochemistry, are used as the basis for problems that can be discussed further in small groups. Medical cases provide an interesting context for biochemistry with video…

  11. Case study the poultry industry in Colombia

    OpenAIRE

    Gomez, Miguel I.; Sierra, Diego M.; Rodriguez, Daisy

    2003-01-01

    "As developing countries open their economies further to trade, their food industries are striving to raise safety and quality standards in order to compete in new markets. Such is the case with the Colombian poultry industry... Critical questions face the Colombian poultry industry: Is it ready to compete with foreign poultry producers on price, quality, and safety? Can industry efforts to produce better quality products assure an increased share of domestic and regional markets? This brief ...

  12. Orbital dermoid and epidermoid cysts: Case study

    Directory of Open Access Journals (Sweden)

    Veselinović Dragan

    2010-01-01

    Full Text Available Introduction. Dermoid and epidermoid cysts of the orbit belong to choristomas, tumours that originate from the aberrant primordial tissue. Clinically, they manifest as cystic movable formations mostly localized in the upper temporal quadrant of the orbit. They are described as both superficial and deep formations with most frequently slow intermittent growth. Apart from aesthetic effects, during their growth, dermoid and epidermoid cysts can cause disturbances in the eye motility, and in rare cases, also an optical nerve compression syndrome. Case Outline. In this paper, we described a child with a congenital orbital dermoid cyst localized in the upper-nasal quadrant that was showing signs of a gradual enlargement and progression. The computerized tomography revealed a cyst of 1.5-2.0 cm in size. At the Maxillofacial Surgery Hospital in Niš, the dermoid cyst was extirpated in toto after orbitotomy performed by superciliary approach. Postoperative course was uneventful, without inflammation signs, and after two weeks excellent functional and aesthetic effects were achieved. Conclusion. Before the decision to treat the dermoid and epidermoid cysts operatively, a detailed diagnostic procedure was necessary to be done in order to locate the cyst precisely and determine its size and possible propagation into the surrounding periorbital structures. Apart from cosmetic indications, operative procedures are recommended in the case of cysts with constant progressions, which cause the pressure to the eye lobe, lead to motility disturbances and indirectly compress the optical nerve and branches of the cranial nerves III, IV and VI.

  13. Collodion baby: a follow-up study of 17 cases.

    Science.gov (United States)

    Van Gysel, D; Lijnen, R L P; Moekti, S S; de Laat, P C J; Oranje, A P

    2002-09-01

    Seventeen cases of collodion baby are reported. Clinical aspects, complications, treatment, final outcome and family history were studied. We did not observe any clinical features in the collodion baby that could serve as a clue in predicting the final diagnosis. Infections were observed in nine, hypothermia in five and hypernatraemic dehydration in four cases. Skin infection mainly occurred in babies treated with emollients (petrolatum, lanolin and cetomacrogolis cream were used). We therefore recommend treating the collodion baby in a humidified incubator, if necessary with intravenous rehydration, but not to use emollients. The final outcome of these study patients was erythrodermic autosomal recessive lamellar ichthyosis in seven cases (41%), non-erythrodermic autosomal recessive lamellar ichthyosis in three cases (18%), Sjögren-Larsson in one case (6%), epidermolytic hyperkeratosis in one case (6%), acute neonatal variant of Gaucher disease in one case (6%) and normal skin in four cases (24%).

  14. USING CASE STUDIES AS AN APPROACH FOR CONDUCTING AGRIBUSINESS RESEARCH

    OpenAIRE

    Sterns, James A.; Schweikhardt, David B.; Peterson, H. Christopher

    1998-01-01

    Many agricultural economists are not familiar with case study research, yet the approach is a useful means of collecting data, and building and testing theory. Case study research has a prescribed set of objectives, epistemology, methodology, and methods that have been developed and tested in a wide range of scholarly and pragmatic situations. This paper reviews these fundamentals, and then demonstrates the case study approach within the context of an agribusiness research project. This appli...

  15. Use of Case Studies for Stimulating Thinking and Learning.

    Science.gov (United States)

    Zeakes, Samuel J.

    Noting that a case-study approach can stimulate student thinking and learning, this paper describes how students in a writing-intensive course on parasitology wrote brief medical case studies of parasites already studied for other students to read, evaluate, and identify the parasite. The paper presents a brief description of the course, an…

  16. Pityriasis amiantacea: a study of seven cases*

    Science.gov (United States)

    Amorim, Gustavo Moreira; Fernandes, Nurimar Conceição

    2016-01-01

    Pityriasis amiantacea was first described in 1832. The disease may be secondary to any skin condition that primarily affects the scalp, including seborrheic dermatitis. Its pathogenesis remains uncertain. We aim to analyze the epidemiological and clinical profiles of patients with pityriasis amiantacea to better understand treatment responses. We identified seven cases of pityriasis amiantacea and a female predominance in a sample of 63 pediatric patients with seborrheic dermatitis followed for an average of 20.4 months. We reported a mean age of 5.9 years. Five patients were female, with a mean age of 9 years. All patients were successfully treated with topic ketoconazole.

  17. Understanding Support - lessons from a case study

    OpenAIRE

    Chris Sauer

    1993-01-01

    Support from top management and others is agreed to be an important factor in information systems success and failure, but little is written about how it has its effect and how it might be managed to a project's advantage. A recently developed conceptual framework is described. It covers the nature and forms of support, the way support affects project outcomes, the bases on which support is provided, and the strategies by which support may be managed. The framework is used to analyse a case s...

  18. Pelvic kidney in organ donation: case study.

    Science.gov (United States)

    Yushkov, Yuriy; Giudice, Anthony

    2009-12-01

    An ectopic kidney is a rare congenital anomaly that occurs when the kidney fails to ascend to its normal position. Often an ectopic kidney is asymptomatic and the kidney is an unexpected finding during organ recovery. The kidney described in this case report had normal function and could have been used for transplantation, if it had been recovered without 2 renal arteries being damaged because of anatomic variation. The renal vasculature in this type of abnormality usually ascends from the iliac vessels, and this variation in anatomy should be taken into consideration by the recovering surgeon during arterial cannulation for organ flushing. PMID:20050461

  19. Case studies for developing globally responsible engineers

    OpenAIRE

    Global Dimension in Engineering Education

    2015-01-01

    Document realitzat amb un ajut financer de la Unió Europea. Per poder accedir al material complementari per a docents dels 28 casos estudi que formen el llibre, activeu el "Document relacionat" Col·lecció de 28 casos estudi per a professors d'enginyeria: 1. Rural development and planning in LDCs: the “Gamba Deve – Licoma axis”,district of Caia, Mozambique 2. Reducing the impact of soil erosion and reservoir siltation on agricultural production and water availability: the case stu...

  20. Understanding energy poverty - Case study: Tajikistan

    Energy Technology Data Exchange (ETDEWEB)

    Robic, Slavica; Olshanskaya, Marina; Vrbensky, Rastislav; Morvaj, Zoran

    2010-09-15

    Access and affordability to energy services determine the state of energy poverty; however, there is no widely applicable definition of energy poverty and no universal set of measures for its eradication exists. This paper offers a new definition and possible solution for decrease, and eventually eradication, of energy poverty for the specific case of Tajikistan. As eradication of energy poverty needs to go in hand with nature preservation and economic development, authors provide possible approach to decrease of energy poverty in Tajikistan while simultaneously preserving nature and boosting the local economy.

  1. STUDY OF SIGNIFICANCE OF PLATELET COUNT IN FEVER CASES

    Directory of Open Access Journals (Sweden)

    Vasavilatha

    2015-01-01

    Full Text Available AIM: To study the significance of platelet count in various fevers and also identify the common causes of fever with thrombocytopenia . MATERIALS AND METHODS: 69 patients who were admitted with fever over 2 months of period from 15th October to15th December 2014 in King George Hospital AMC Visakhapatnam studied retrospectively. RESULTS: INCIDENCE: More than half of the cases (52.2% admitted with fever have thrombocytopenia. SEX: The study reveals that irrespective of sex and size of the sample the presentation of fever with/ without thromb ocytopenia could not found any significant difference . Degree of thrombocytopenia in various etiologies: in the present study it is found that out of 15 cases of falciparum malaria 10 cases had thrombocytopenia. Out of 12 undiagnosed cases 8 cases had thro mbocytopenia. Out of 4 cases of gastro intestinal system 3 cases had thrombocytopenia. In the present study it is significantly found that the highest difference is noticed in the presentation of dengue cases. Out of total sample (69 cases it is found tha t 5cases (7.2% of thrombocytopenia with dengue fever were found against 1case (1.4% of dengue fever with normal plate let count. The present study reveals that there is significant difference among various diseases such as malaria 14 (16.6%, dengue feve r 5 (13.9%, Urinary tract infection 2 (5.6%, undiagnosed cases 8 (22.2%. However severe thrombocytopenia (platelets less than 50,000 is seen in14 cases (38.8%out of 36 cases of fever with thrombocytopenia. Further this study reveals that in the cases of malaria 50% of cases reported as severe thrombocytopenia 7cases (19.4% followed by dengue fever3 cases (8.3%. CONCLUSION: Not only malaria, dengue fever and urinary tract infection can also cause severe thrombocytopenia. Fever cases especially with th rombocytopenia show seasonal variations, they are seen commonly in early winter. Febrile thrombocytopenia still presents as atypical and occult forms making

  2. Exploiting Natural Variation in Arabidopsis

    NARCIS (Netherlands)

    Molenaar, J.A.; Keurentjes, J.J.B.

    2014-01-01

    Natural variation for many traits is present within the species Arabidopsis thaliana . This chapter describes the use of natural variation to elucidate genes underlying the regulation of quantitative traits. It deals with the development and use of mapping populations, the detection and handling of

  3. Exploiting natural variation in Arabidopsis

    NARCIS (Netherlands)

    J.A. Molenaar; J.J.B. Keurentjes

    2014-01-01

    Natural variation for many traits is present within the species Arabidopsis thaliana. This chapter describes the use of natural variation to elucidate genes underlying the regulation of quantitative traits. It deals with the development and use of mapping populations, the detection and handling of g

  4. Does Pregnancy-Associated Breast Cancer Imply a Worse Prognosis? A Matched Case-Case Study

    Science.gov (United States)

    Dimitrakakis, Constantine; Zagouri, Flora; Tsigginou, Alexandra; Marinopoulos, Spyros; Sergentanis, Theodoros N.; Keramopoulos, Antonis; Zografos, George C.; Ampela, Konstantina; Mpaltas, Dimosthenis; Papadimitriou, Christos; Dimopoulos, Meletios-Athanassios; Antsaklis, Aris

    2013-01-01

    Summary Background Significant controversy exists in the literature regarding the role of pregnancy in the prognosis of breast cancer. We designed a matched case-case study, matching pregnancy-associated breast cancer (PABC) cases with breast cancer cases for stage, age, and year of diagnosis. Patients and Methods 39 consecutive cases of PABC were matched with 39 premenopausal cases of breast cancer. Univariate and multivariate survival analyses followed by adjustment for stage, grade, estrogen receptor status, and age at diagnosis, were performed. Results Regarding overall survival (OS), univariate analysis pointed to longer OS in non-PABC cases vs. PABC cases. Accordingly, a more advanced stage predicted shorter survival. In the multivariate analysis, the independent aggravating effect mediated by pregnancy persisted. Interestingly, a post hoc nested analysis within PABC cases indicated that the 3rd trimester pointed to shorter OS. The aforementioned results on OS were also replicated during the examination of relapse-free survival. Conclusion Implementing a matched case-case design, the present study points to pregnancy as a poor prognostic factor for breast cancer. PMID:24415971

  5. Transmission electron microscopy of ameloblastoma: A study on six cases

    OpenAIRE

    Chawla, Rajeshwar; Ramalingam, Karthikeyan; Sarkar, Amitabha; Muddiah, Savita

    2013-01-01

    Background: Ameloblastoma is a rare, benign tumor of odontogenic epithelium, but with an aggressive clinical behavior. Aim: The present study aims to assess the ultramicroscopic features of the epithelial and connective tissue components of ameloblastoma. Materials and Methods: Six cases of ameloblastoma were subjected to electron microscopy. They included three cases of follicular type and three cases of plexiform type. Results: The study reveals that the ameloblastoma contains the full comp...

  6. THE APPLICATION OF CASE STUDY IN ENGINEERING DRAWING COURSE

    OpenAIRE

    Zhang, Wenying; Yuan, Yuefeng

    2015-01-01

    The paper describes the case study in engineering drawing course in the process of assembly drawing by using customized software. The process is reflecting three steps of an engineering case solving: design, processing and installation. Using case study for design drawings students can master the main components of assembly drawing, understand assembly drawing and learn the AutoCAD software. All this can improve the quality of teaching.

  7. Studying Tourism Indicators In Iran (Case Study: Khoramabad City

    Directory of Open Access Journals (Sweden)

    Mahdi Garavand

    2014-12-01

    Full Text Available Now tourism industry is one of the greatest World Industries from point of view development and with attention to be use financial sources and involved persons with that. This industry, has third rank in financial and commercial classifications and including more than 7 percent of whole world exports, also it influence gross national product in all countries; so that increase rate of gross national product 2billion $ in all world nations. Tourism industry important to stress tow important ways: first, the dynamic familiarity with other cultures, nations, races, tribes, dialects and …; second, it provides sources of income and foreign exchanges from an economic point of view. The different world countries fallowed attraction of tourists because of that they have various facilities and various attractions.Iran is ranked as one of the 10 top attractive countries in the world but Iran was place 114th ranking of the countries in terms of attracting tourists (World Economic Forum, 2011, tourism receipts is ranked as 77th, and the number of international tourists arrivals ranked as place 70th (UNWTO, 2009.So, the aim of this research is, studying main indicators in tourism location in order to improving their qualify. This research is qualitative. Also was used the "Descriptive/ Explanatory" through contain analysis. The research method are phenomenological, conceptual and constructive theory in field of tourism industry in context of Iran, Which eventually is bound to lead to the development of tourism industry in Iran. The strategy of this research is qualitative method by using case study in the area of tourism industry in fabric of Iran. So, was introduced touristic-historical building. Then according to visitor comments was ranked. At finally was used T-Test method in order to analyzing hypothesis.

  8. Complexity, Representation and Practice: Case Study as Method and Methodology

    Science.gov (United States)

    Miles, Rebecca

    2015-01-01

    While case study is considered a common approach to examining specific and particular examples in research disciplines such as law, medicine and psychology, in the social sciences case study is often treated as a lesser, flawed or undemanding methodology which is less valid, reliable or theoretically rigorous than other methodologies. Building on…

  9. Using Clinical Gait Case Studies to Enhance Learning in Biomechanics

    Science.gov (United States)

    Chester, Victoria

    2011-01-01

    Clinical case studies facilitate the development of clinical reasoning strategies through knowledge and integration of the basic sciences. Case studies have been shown to be more effective in developing problem-solving abilities than the traditional lecture format. To enhance the learning experiences of students in biomechanics, clinical case…

  10. A Case Study on Special Education in the Philippines.

    Science.gov (United States)

    Pascual, Dolores M.; Gregorio, Julieta A.

    This case study, undertaken as part of a Unesco survey of its member states, documents facilities and services for the education of disabled persons in the Philippines. The case study reports that Philippine children and youth with special needs are provided with access to educational opportunities that develop their potential and enable them to…

  11. Using a Case-Study Article to Effectively Introduce Mitosis

    Science.gov (United States)

    Van Hoewyk, Doug

    2007-01-01

    Community college students in a nonmajors biology class are introduced to mitosis by reading a case-study article that allows them to gauge how many times various parts of their bodies have been regenerated. The case-study article allows students to develop a conceptual framework of the cell cycle prior to a lecture on mitosis. (Contains 1 figure.)

  12. Case Study: Student-Produced Videos for the Flipped Classroom

    Science.gov (United States)

    Prud'homme-Genereux, Annie

    2016-01-01

    This column provides original articles on innovations in case study teaching, assessment of the method, as well as case studies with teaching notes. This month's issue describes a way of building a library of student-produced videos to use in the flipped classroom.

  13. Hamlet's Suicide Soliloquy: A Case Study in Suicide Ideology.

    Science.gov (United States)

    Jenkins, Andrew P.

    This paper presents a secondary-level teaching technique that can be used in an integrated English and health education curriculum. The exercise provides students and teachers with a case study of a suicidal person for the purpose of teaching the warning signs of suicide, appropriate questioning, and referral skills. The case study uses Hamlet's…

  14. A Case Study in Elementary Statistics: The Florida Panther Population

    Science.gov (United States)

    Lazowski, Andrew; Stopper, Geffrey

    2013-01-01

    We describe a case study that was created to intertwine the fields of biology and mathematics. This project is given in an elementary probability and statistics course for non-math majors. Some goals of this case study include: to expose students to biology in a math course, to apply probability to real-life situations, and to display how far a…

  15. Release and deployment at Planon: a case study

    NARCIS (Netherlands)

    Jansen, R.L.; Ballintijn, G.C.; Brinkkemper, S.

    2005-01-01

    This case study report describes the research results of a case study at Planon into the processes of development, release, and deployment. The research was done to document the release and deployment processes at Planon, to uncover strengths and weaknesses in these processes, and to compare Planon

  16. Bridging the Performance Gap with Ergonomics: A Case Study

    Science.gov (United States)

    Rethaber, James D.

    2011-01-01

    Faced with increased incidences of work-related strain and sprain injuries and OSHA-recordable injuries, the organization in this case study details how it resolved these performance-related issues. This case study also demonstrates the effectiveness of Thomas Gilbert's (1978) Behavior Engineering Model as a tool for analyzing, defining, and…

  17. Using the Case Study Method in Teaching College Physics

    Science.gov (United States)

    Burko, Lior M.

    2016-01-01

    The case study teaching method has a long history (starting at least with Socrates) and wide current use in business schools, medical schools, law schools, and a variety of other disciplines. However, relatively little use is made of it in the physical sciences, specifically in physics or astronomy. The case study method should be considered by…

  18. Cancer Advocacy in Africa: case studies of innovative practices

    OpenAIRE

    Odedina, Folakemi T; Rodrigues, Belmira

    2013-01-01

    In this paper, we present six case studies describing innovative cancer advocacy programs in Africa. For each case study, an example of an advocacy activity, list of factors contributing to the success of the organization, and an example of an obstacle addressed by the organization are described.

  19. The Case Study: A Strategy for Gifted Students.

    Science.gov (United States)

    McMahon, Edward T.

    1982-01-01

    Using the case study method as the primary teaching strategy in law-related education is particularly appropriate with gifted students because of its emphasis on critical thinking and independent learning. Steps in the case study approach are reviewed, and a sample clasroom application of the approach is offered. (Author/SW)

  20. Nanomaterial Case Studies: Nanoscale Titanium Dioxide (External Review Draft)

    Science.gov (United States)

    This draft document presents two case studies of nanoscale titanium dioxide (nano-TiO2) used (1) to remove arsenic from drinking water and (2) as an active ingredient in topical sunscreen. The draft case studies are organized around a comprehensive environmental asses...

  1. A Case Study of Three EFL Learners

    Institute of Scientific and Technical Information of China (English)

    朱思亲

    2014-01-01

    This study is a sample to reflect the current learning situations of senior high school students on learning English. Through interviewing three level students, this study reveals that interests, acquisition and learning, and anxiety are the factors that influence students’ EFL attainment.

  2. Brazil Low Carbon Case Study : Waste

    OpenAIRE

    World Bank

    2010-01-01

    This report synthesis the findings for the waste sector of a broader study, the Brazil low carbon study, which was undertaken by the World Bank in its initiative to support Brazil's integrated effort towards reducing national and global emissions of Greenhouse Gases (GHG) while promoting long term development. The purpose of the present report is to assist in the preparation of public poli...

  3. Masculinity Studies: The Case of Brando

    Science.gov (United States)

    Pinto, Samantha

    2011-01-01

    This reflective article interrogates the role of masculinity studies in the women's and gender studies' classroom by looking at the work of American film icon Marlon Brando. Brando and his risky masculinity in the film represents a locale of "dangerous desires" which reveal deep conflict in student perceptions of men, women, and gender. (Contains…

  4. A molecular-genetic approach to studying source-sink interactions in Arabidopsis thaliana. Final report, April 1, 1995--March 31, 1998

    Energy Technology Data Exchange (ETDEWEB)

    Gibson, S.I.

    1998-11-01

    The ultimate goal of this research is to elucidate the molecular mechanisms by which the complex interactions between sources and sinks of fixed carbon are controlled in plants. As soluble sugar levels have been shown to play a vital role in a variety of source-sink interactions, a key aspect of the authors research is to determine the role of sugar-regulated gene expression in mediating source-sink interactions. In addition, as a critical aspect of source-sink interactions is the channeling of fixed carbon into different storage forms, they have pursued the findings that fumaric acid represents a significant form of storage carbon in Arabidopsis thaliana and other plant species. In the future, a better understanding of the mechanisms by which interactions between sources and sinks of fixed carbon are coordinated will be a pre-requisite to developing more rationale approaches to improving harvest indices in crop species.

  5. Arabidopsis Rab Geranylgeranyltransferases Demonstrate Redundancy and Broad Substrate Specificity in Vitro.

    Science.gov (United States)

    Shi, Wan; Zeng, Qin; Kunkel, Barbara N; Running, Mark P

    2016-01-15

    Posttranslational lipid modifications mediate the membrane attachment of Rab GTPases, facilitating their function in regulating intracellular vesicular trafficking. In Arabidopsis, most Rab GTPases have two C-terminal cysteines and potentially can be double-geranylgeranylated by heterodimeric Rab geranylgeranyltransferases (Rab-GGTs). Genes encoding two putative α subunits and two putative β subunits of Rab-GGTs have been annotated in the Arabidopsis thaliana genome, but little is known about Rab-GGT activity in Arabidopsis. In this study, we demonstrate that four different heterodimers can be formed between putative Arabidopsis Rab-GGT α subunits RGTA1/RGTA2 and β subunits RGTB1/RGTB2, but only RGTA1·RGTB1 and RGTA1·RGTB2 exhibit bona fide Rab-GGT activity, and they are biochemically redundant in vitro. We hypothesize that RGTA2 function might be disrupted by a 12-amino acid insertion in a conserved motif. We present evidence that Arabidopsis Rab-GGTs may have preference for prenylation of C-terminal cysteines in particular positions. We also demonstrate that Arabidopsis Rab-GGTs can not only prenylate a great variety of Rab GTPases in the presence of Rab escort protein but, unlike Rab-GGT in yeast and mammals, can also prenylate certain non-Rab GTPases independently of Rab escort protein. Our findings may help to explain some of the phenotypes of Arabidopsis protein prenyltransferase mutants. PMID:26589801

  6. Cytological and molecular characterization of non-host resistance in Arabidopsis thaliana against wheat stripe rust.

    Science.gov (United States)

    Cheng, Yulin; Zhang, Hongchang; Yao, Juanni; Han, Qingmei; Wang, Xiaojie; Huang, Lili; Kang, Zhensheng

    2013-01-01

    Wheat stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is one of the most destructive diseases of wheat worldwide. We report the use of the non-host plant Arabidopsis thaliana to identify the basis of resistance to Pst at the cytological and molecular levels. No visible symptoms were observed on Arabidopsis leaves inoculated with Pst. Microscopic observations showed that significantly reduced numbers of Pst urediospores had successfully achieved penetration in Arabidopsis compared with those in wheat. There were significant differences in the frequency of stomatal penetration but not in fungal growth among different Pst races in Arabidopsis. The fungus failed to successfully form haustoria in Arabidopsis and attempted infection induced an active response including accumulation of phenolic compounds and callose deposition in plant cells. A set of defence-related genes were also up regulated during the Pst infection. Compared with wild type plants, increased fungal growth was observed in an npr1-1 mutant and in NahG transformed plants, which both are insensitive to salicylic acid. However, treatment of Arabidopsis plants with cytochalasin B, an inhibitor of actin microfilament polymerization, did not increase susceptibility to Pst. Our results demonstrate that Arabidopsis can be used to study mechanisms of non-host resistance to wheat stripe rust, and highlight the significance of participation of salicylic acid in non-host resistance to rust fungi.

  7. only: A Case Study In Projective Meaning

    Directory of Open Access Journals (Sweden)

    Craige Roberts

    2010-12-01

    Full Text Available I offer an integrated theory of the meaning of only in which the prejacent, while not presupposed, is both entailed and backgrounded, hence tends to project (following a general proposal about projection due to Simons et al. 2010. Moreover, I argue, contra Beaver & Brady (2008, that only is not conventionally associated with focus, the focus effects arising instead pragmatically. But I do adopt aspects of their semantics for only, including the presupposition of a pre-order over the elements of its domain.ReferencesAbbott, B. 2000. ‘Presuppositions as non-assertions’. Journal of Pragmatics 32: 1419–37.http://dx.doi.org/10.1016/S0378-2166(9900108-3Abbott, B. 2008. ‘Presuppositions and common ground’. Linguistics and Philosophy 31: 523–538.http://dx.doi.org/10.1007/s10988-008-9048-8Amaral, P. 2010. ‘Entailment, assertion, and textual coherence: the case of almost and barely’. Linguistics 48, no. 3: 525–545.http://dx.doi.org/10.1515/LING.2010.016Amaral, P., Roberts, C. & Allyn Smith, E. 2008. ‘Review of The Logic of Conventional Implicature by Chris Potts’. Linguistics and Philosophy 30: 707–749.http://dx.doi.org/10.1007/s10988-008-9025-2Atlas, J. D. 1993. ‘The importance of being “only”: testing the neo-Gricean versus neoentailment paradigms’. Journal of Semantics 10: 301–18.http://dx.doi.org/10.1093/jos/10.4.301Beaver, D. 2001. Presupposition and Assertion in Dynamic Semantics. CSLI Publications, Stanford, CA.Beaver, D. 2010. ‘Handout from a talk on projective meaning’. Stuttgart, Germany.Beaver, D. & Brady, C. 2003. ‘Always and Only: Why not all focus sensitive operators are alike’. Natural Language Semantics 11: 323–62.http://dx.doi.org/10.1023/A:1025542629721Beaver, D. & Brady, C. 2008. Sense and Sensitivity. Blackwell.http://dx.doi.org/10.1002/9781444304176Beckman, M. E. & Ayers, G. M. 1994. ‘Guidelines for ToBI labeling guide, ver. 2.0’. On-line at The Ohio State University: www

  8. 磷脂酶D对拟南芥抗冻性的影响%Study on the Effect of Phospholipase D on the Freezing Tolerance of Arabidopsis thaliana

    Institute of Scientific and Technical Information of China (English)

    赵鹏; 王道龙

    2011-01-01

    为了探索磷脂酶D(PLD)在调控植物抗冻性中的作用,进一步揭示植物抗冻机理和磷脂低温信号转导机制的研究.笔者应用人工气候霜箱,对PLDγ1、PLDγ3基因分别被敲除的拟南芥突变体及野生型材料,进行低温驯化和冻害胁迫处理.试验发现,这2个基因的敲除型无论是经过还是未经过低温驯化冻害处理的离子渗漏率都与相同处理野生型拟南芥的离子渗漏率无显著差异.试验结果表明,PLDT,1和PLDy3这2个基因既未参与组成型调控植物的抗冻性,也未参与低温信号转导过程.%The experiment was purposely to research the effect of phospholipase D on the freezing tolerance of Arabidopsis thaliana, reveal the mechanism of plants freezing tolerance and phospholipid signal transduction.Arabidopsis thaliana mutant PLDγ1 or PLDγ3 was deficient and wild-type was used as materials.The two mutants and wild-type were cold acclimated and freezing stressed using a climate chamber.There were no significant differences between the ion leakage of the mutants and wild-type whether cold acclimation freeze or non-acclimation freeze.The results showed that PLDγ1 and PLDγ3 neither mediate regulation of constitutive freezing tolerance nor low temperature signaling.

  9. Effect of cultural conditions on the seed-to-seed growth of Arabidopsis and Cardamine - A study of growth rates and reproductive development as affected by test tube seals

    Science.gov (United States)

    Hoshizaki, T.

    1982-01-01

    The effects of test tube seals on the growth, flowering, and seed pod formation of Arabidopsis thaliana (L.) Heynh., mouse ear cress, and Cardamine oligosperma Nutt, bitter cress, are studied in order to assess the conditions used in weightlessness experiments. Among other results, it is found that the growth (height) and flowering (date of bud appearance) were suppressed in mouse ear cress in tubes sealed with Saran. Seed pod formation which occurred by day 45 in open-to-air controls, was still lacking in the sealed plants even up to day 124. The growth and flowering of bitter cress were also suppressed by the Saran seal, although up to day 55 the Saran-sealed plants were taller. It is suggested that atmospheric composition was the cause of the suppression of growth, flowering, and seed pod development in these plants, since the mouse ear cress renewed their growth and then set seed pods after the Saran seal was ruptured.

  10. Overexpression of Arabidopsis AnnAt8 Alleviates Abiotic Stress in Transgenic Arabidopsis and Tobacco

    Science.gov (United States)

    Yadav, Deepanker; Ahmed, Israr; Shukla, Pawan; Boyidi, Prasanna; Kirti, Pulugurtha Bharadwaja

    2016-01-01

    Abiotic stress results in massive loss of crop productivity throughout the world. Because of our limited knowledge of the plant defense mechanisms, it is very difficult to exploit the plant genetic resources for manipulation of traits that could benefit multiple stress tolerance in plants. To achieve this, we need a deeper understanding of the plant gene regulatory mechanisms involved in stress responses. Understanding the roles of different members of plant gene families involved in different stress responses, would be a step in this direction. Arabidopsis, which served as a model system for the plant research, is also the most suitable system for the functional characterization of plant gene families. Annexin family in Arabidopsis also is one gene family which has not been fully explored. Eight annexin genes have been reported in the genome of Arabidopsis thaliana. Expression studies of different Arabidopsis annexins revealed their differential regulation under various abiotic stress conditions. AnnAt8 (At5g12380), a member of this family has been shown to exhibit ~433 and ~175 fold increase in transcript levels under NaCl and dehydration stress respectively. To characterize Annexin8 (AnnAt8) further, we have generated transgenic Arabidopsis and tobacco plants constitutively expressing AnnAt8, which were evaluated under different abiotic stress conditions. AnnAt8 overexpressing transgenic plants exhibited higher seed germination rates, better plant growth, and higher chlorophyll retention when compared to wild type plants under abiotic stress treatments. Under stress conditions transgenic plants showed comparatively higher levels of proline and lower levels of malondialdehyde compared to the wild-type plants. Real-Time PCR analyses revealed that the expression of several stress-regulated genes was altered in AnnAt8 over-expressing transgenic tobacco plants, and the enhanced tolerance exhibited by the transgenic plants can be correlated with altered expressions of

  11. Bilingual education in Slovakia: A Case Study

    Directory of Open Access Journals (Sweden)

    Silvia Pokrivčáková

    2013-06-01

    The paper includes partial results of the research project KEGA 036UKF-4/2013 Creating university textbooks and multimedia courses for a new study program funded by the Ministry of Education of the Slovak Republic.

  12. Wind farm repowering: A case study

    Energy Technology Data Exchange (ETDEWEB)

    Selva, L. [Renewable Energy Eng. (Spain); Canas, M.; Gomez, E.; Pujante, A [Renewable Energy Research Inst., Dept. of Electrical, Electronic and Control Eng. (Spain)

    2007-11-15

    Wind farm repowering involves the replacement of smaller and middle sized wind turbines, with state-of-the-art multi-megawatt turbines. In this paper, a detailed study of the repowering of a wind farm is presented, by computing the generated active power from existing wind turbines and the new ones. The active power generated with the wind turbines are totalized to obtain the yearly generated energy and analyzed, thus economic studies take the repowering cost into account too. (au)

  13. Arabidopsis Heterotrimeric G-protein Regulates Cell Wall Defense and Resistance to Necrotrophic Fungi

    Institute of Scientific and Technical Information of China (English)

    Magdalena Delcado-Cerezo; Paul Schulze-Lefert; Shauna Somerville; José Manuel Estevez; Staffan Persson; Antonio Molina; Clara Sánchez-Rodríguez; Viviana Escudero; Eva Miedes; Paula Virginia Fernández; Lucía Jordá; Camilo Hernández-Blanco; Andrea Sánchez-Vallet; Pawel Bednarek

    2012-01-01

    The Arabidopsis heterotrimeric G-protein controls defense responses to necrotrophic and vascular fungi.The agb1 mutant impaired in the Gβ subunit displays enhanced susceptibility to these pathogens.Gβ/AGB1 forms an obligate dimer with either one of the Arabidopsis Gγ subunits (γ1/AGG1 and γ2/AGG2).Accordingly,we now demonstrate that the agg1 agg2 double mutant is as susceptible as agb1 plants to the necrotrophic fungus Plectosphaerella cucumerina.To elucidate the molecular basis of heterotrimeric G-protein-mediated resistance,we performed a comparative transcriptomic analysis of agb1-1 mutant and wild-type plants upon inoculation with P cucumerina.This analysis,together with metabolomic studies,demonstrated that G-protein-mediated resistance was independent of defensive pathways required for resistance to necrotrophic fungi,such as the salicylic acid,jasmonic acid,ethylene,abscisic acid,and tryptophan-derived metabolites signaling,as these pathways were not impaired in agb1 and agg1 agg2 mutants.Notably,many mis-regulated genes in agb1 plants were related with cell wall functions,which was also the case in agg1 agg2 mutant.Biochemical analyses and Fourier Transform InfraRed (FTIR) spectroscopy of cell walls from G-protein mutants revealed that the xylose content was lower in agb1 and agg1 agg2 mutants than in wild-type plants,and that mutant walls had similar FTIR spectratypes,which differed from that of wild-type plants.The data presented here suggest a canonical functionality of the Gβ and Gγ1/γ2 subunits in the control of Arabidopsis immune responses and the regulation of cell wall composition.

  14. Wrinkled1, a ubiquitous regulator in oil accumulating tissues from Arabidopsis embryos to oil palm mesocarp.

    Directory of Open Access Journals (Sweden)

    Wei Ma

    Full Text Available Wrinkled1 (AtWRI1 is a key transcription factor in the regulation of plant oil synthesis in seed and non-seed tissues. The structural features of WRI1 important for its function are not well understood. Comparison of WRI1 orthologs across many diverse plant species revealed a conserved 9 bp exon encoding the amino acids "VYL". Site-directed mutagenesis of amino acids within the 'VYL' exon of AtWRI1 failed to restore the full oil content of wri1-1 seeds, providing direct evidence for an essential role of this small exon in AtWRI1 function. Arabidopsis WRI1 is predicted to have three alternative splice forms. To understand expression of these splice forms we performed RNASeq of Arabidopsis developing seeds and queried other EST and RNASeq databases from several tissues and plant species. In all cases, only one splice form was detected and VYL was observed in transcripts of all WRI1 orthologs investigated. We also characterized a phylogenetically distant WRI1 ortholog (EgWRI1 as an example of a non-seed isoform that is highly expressed in the mesocarp tissue of oil palm. The C-terminal region of EgWRI1 is over 90 amino acids shorter than AtWRI1 and has surprisingly low sequence conservation. Nevertheless, the EgWRI1 protein can restore multiple phenotypes of the Arabidopsis wri1-1 loss-of-function mutant, including reduced seed oil, the "wrinkled" seed coat, reduced seed germination, and impaired seedling establishment. Taken together, this study provides an example of combining phylogenetic analysis with mutagenesis, deep-sequencing technology and computational analysis to examine key elements of the structure and function of the WRI1 plant transcription factor.

  15. Wrinkled1, a ubiquitous regulator in oil accumulating tissues from Arabidopsis embryos to oil palm mesocarp.

    Science.gov (United States)

    Ma, Wei; Kong, Que; Arondel, Vincent; Kilaru, Aruna; Bates, Philip D; Thrower, Nicholas A; Benning, Christoph; Ohlrogge, John B

    2013-01-01

    Wrinkled1 (AtWRI1) is a key transcription factor in the regulation of plant oil synthesis in seed and non-seed tissues. The structural features of WRI1 important for its function are not well understood. Comparison of WRI1 orthologs across many diverse plant species revealed a conserved 9 bp exon encoding the amino acids "VYL". Site-directed mutagenesis of amino acids within the 'VYL' exon of AtWRI1 failed to restore the full oil content of wri1-1 seeds, providing direct evidence for an essential role of this small exon in AtWRI1 function. Arabidopsis WRI1 is predicted to have three alternative splice forms. To understand expression of these splice forms we performed RNASeq of Arabidopsis developing seeds and queried other EST and RNASeq databases from several tissues and plant species. In all cases, only one splice form was detected and VYL was observed in transcripts of all WRI1 orthologs investigated. We also characterized a phylogenetically distant WRI1 ortholog (EgWRI1) as an example of a non-seed isoform that is highly expressed in the mesocarp tissue of oil palm. The C-terminal region of EgWRI1 is over 90 amino acids shorter than AtWRI1 and has surprisingly low sequence conservation. Nevertheless, the EgWRI1 protein can restore multiple phenotypes of the Arabidopsis wri1-1 loss-of-function mutant, including reduced seed oil, the "wrinkled" seed coat, reduced seed germination, and impaired seedling establishment. Taken together, this study provides an example of combining phylogenetic analysis with mutagenesis, deep-sequencing technology and computational analysis to examine key elements of the structure and function of the WRI1 plant transcription factor. PMID:23922666

  16. Reproductive Risk Factors for Breast Cancer: A Case Control Study

    OpenAIRE

    Meshram II; Hiwarkar PA; Kulkarni PN

    2009-01-01

    Background: Breast cancer is second most important cancer among Indian women. Although risk factors are not much prevalent as in western countries, incidence rate is increasing in India. The study was undertaken to study various risk factors associated with breast cancer. Methods: A hospital based group matched case control study was undertaken to identify risk factors. The study consisted of 105 hospitalized cases confirmed on histopathology and 210 group matched controls selected from urban...

  17. Repowering of wind farms - A case study

    Energy Technology Data Exchange (ETDEWEB)

    Nivedh, B.S. [Quality Engineering and Software Technologies, Bangalore (India); Devi, R.P.K. [College of Engineering. Power Systems Engineering, Guindy (India); Sreevalsan, E. [Gamesa Wind Turbines India Private Limited, Chennai (India)

    2012-07-01

    The main objective of the study is to devise a method for assessing the repowering potential and to improve the energy output from the wind farms and also to understand the impact on the power quality due to repowering. With repowering, the first-generation wind turbines can be replaced with modern multi-megawatt wind turbines. To carry-out the study an old wind farm located at Kayathar, Tamilnadu is selected. The wind farm was commissioned in 1990's with a capacity of 7.35MW, which consists of 36 Wind Turbines each with the capacity of 200kW and 225kW. The present annual energy generation of the wind farm is 7350MWhr with the plant load factor of 11.41%. The intent of this study is to predict the annual energy output of the wind farm after the repowering using WAsP (Wind Atlas Analysis Application Program). Further this study analyses the power quality issues of the various Wind Turbines. In addition, the main feeder, in which the wind farm which is taken for the study also modeled and the impact on power quality due to repowering also studied. Simulations were carried out using MATLAB. The results are analyzed to understand the significance of repowering to overcome the energy crisis of the nation since the best locations for wind in India are occupied by old wind turbines. The following are the observations and conclusions from the above study. Plant load factor (PLF) increased to 24 %, Energy yield increased to more than 4 times and the capacity of the wind farm became double. And in the view of power quality, comparing to the existing Feeder, Repowered Feeder having less reactive power consumption, voltage variations and flickers except the harmonic distortion. (Author)

  18. Guidelines for reporting case studies on extracorporeal treatments in poisonings

    DEFF Research Database (Denmark)

    Lavergne, Valéry; Ouellet, Georges; Bouchard, Josée;

    2014-01-01

    A literature review performed by the EXtracorporeal TReatments In Poisoning (EXTRIP) workgroup highlighted deficiencies in the existing literature, especially the reporting of case studies. Although general reporting guidelines exist for case studies, there are none in the specific field...... of extracorporeal treatments in toxicology. Our goal was to construct and propose a checklist that systematically outlines the minimum essential items to be reported in a case study of poisoned patients undergoing extracorporeal treatments. Through a modified two-round Delphi technique, panelists (mostly chosen...... round, with response rates of 96.3% and 98.3%, respectively. Twenty case reports were evaluated at each validation round and the independent raters' response rate was 99.6% and 98.8% per validation round. The final checklist consists of 114 items considered essential for case study reporting...

  19. Bullous disorders in Konya: A study of 93 cases

    Directory of Open Access Journals (Sweden)

    Munise Daye

    2013-12-01

    Full Text Available Background and Design: Bullous disorders are a group of disorders caused by specific antibodies against tissue adhesion molecules in skin and mucosa or genetic inheritance. There are limited detailed epidemiological studies about bullous disorders in Turkey. In this study we evaluated the demographic, clinical, immunopathologic, course and follow-up properties, cases in Konya. Most of cases were in pemphigus and bullous pemphigoid group, so we gave more information about them. Materials and Methods: Ninty three cases that are followed up during the period of 2006-2012 were included in our study. Results: Female cases were %53,8, male cases were %46,2. The mean age was 52,9. In all of cases; %37,6 cases were pemhigus vulgaris, % 34,4 bullous pemphigoid, %15 herediter epidermolysis bullosa, %4,3 were dermatitis herpetiformis, %4,3 were pemphigus foliaceus, %2,2 pemphigus vegetans, %1,1 Hailey- Hailey disease, %1,1 cicatricial pemphigoid. Mean age of Pemhigus vulgaris onset was 45,9 year and mostly it was observed in females. Pemhigus vulgaris has been started at oral mucosae and the time for diagnosis of pemhigus vulgaris, which began at oral mucosae, was longer than other geogrophic regions. Mean age bullous pemphigoid onset was 70 year and mostly it was observed in females. In % 12,5 of cases disease started at oral mucosae. None of the cases had additional autoimmune disorder. We have treated 25 cases with systemic corticosteriods, 41 cases with systemic corticosteriods and adjuvan agents, 11 cases with only one of adjuvan agents, 16 cases with only local streoids. Conclusions: We report the demographic, clinical, immunopathologic, course and follow-up properties of the bullous disorders in Konya.

  20. The research project KLIMAT. Report of carrot case study; Forskningsprosjektet KLIMAT. Rapport fra gulrot case studie

    Energy Technology Data Exchange (ETDEWEB)

    Svanes, Erik

    2012-07-01

    The research project 'KLIMAT' was 1.1.2009 to 31.8.2012. The main goal of this project was to develop a 'best practice' methodology for quantifying the carbon footprint of products with a focus on fruits, vegetables, dairy and meat products. The methodology was tested on six selected case products. One of these products was the carrot. The product was selected because it is a product with high sales volume, a large part of the production takes place in Norway, and it may be assumed to represent the root vegetables which are a very important group of vegetable products. Oestfold Research, in conjunction with BAMA and Gartnerhallen, collected the necessary data to conduct the study. Data came from a group of 13 producers with ties to Laagendalen that all products supplied to the Laagen Gulrot for processing and packing. The producers were voluntarily affiliated with an online reporting system for a variety of information, including information about resource use that were used in this study. Climate track of carrot packed in the cup was, according to the methodology that was developed 0.39 kg Co2-ekv/kg product delivered to the consumer, 0.44 kg Co2-ekv/kg consumed carrot. (Author)

  1. Logistics case study based research: Towards higher quality

    DEFF Research Database (Denmark)

    Pedrosa, Alex; Näslund, Dag; Jasmand, Claudia

    2012-01-01

    analysis of 134 case study based articles published in six leading logistics and supply chain management (SCM) journals between 1998 and 2010 is used to assess and evaluate the quality of the case study based research approach as documented in these publications. Findings – This research provides...... to address to ensure high quality of the case study based research approach in published articles. Research limitations/implications – This study is limited to the analysis of published articles in six logistics and SCM journals. Further research should investigate different journals in logistics and other...

  2. Case study of virtual private network

    Science.gov (United States)

    Hernandez, Harold; Chung, Ping-Tsai

    2001-07-01

    In this study, business benefits for this Virtual Private Network (VPN) and protocols, techniques, equipments used in this VPN are reported. In addition, our design experience for fault tolerance, security and network management and administration on this VPN are showed. Finally, the issues for future planning of this VPN is addressed.

  3. Facebook Groups as LMS: A Case Study

    Science.gov (United States)

    Meishar-Tal, Hagit; Kurtz, Gila; Pieterse, Efrat

    2012-01-01

    This paper describes a pilot study in using Facebook as an alternative to a learning management system (LMS). The paper reviews the current research on the use of Facebook in academia and analyzes the differences between a Facebook group and a regular LMS. The paper reports on a precedent-setting attempt to use a Facebook group as a course…

  4. Knowledge Management Analysis: A Case Study

    Science.gov (United States)

    Mecha, Ezi I.; Desai, Mayur S.; Richards, Thomas C.

    2009-01-01

    It is imperative for businesses to manage knowledge and stay competitive in the marketplace. Knowledge management is critical and is a key to prevent organizations from duplicating their efforts with a subsequent improvement in their efficiency. This study focuses on overview of knowledge management, analyzes the current knowledge management in…

  5. Mixed sensitivity design: An aerospace case study

    NARCIS (Netherlands)

    Kwakernaak, Huibert; Camacho, E.F.; Basanez, L.; Puente, de la J.A.

    2002-01-01

    The mixed sensitivity design method for multivariable linear control systems proposed in the companion paper (Kwakernaak, 2001) is applied to the design of a stability augmentation system for the longitudinal motion of a fighter airplane previously studied by Safonov and Chiang (1988). Both $H_\\inft

  6. Gender, Class and Rurality: Australian Case Studies

    Science.gov (United States)

    Bryant, Lia; Pini, Barbara

    2009-01-01

    The interrelationship between gender and class in rural spaces has received little attention. While rural scholars have focused on the implications for class from processes of gentrification and agricultural and rural restructuring, these analyses have remained largely ungendered. Similarly, feminist rural studies have rarely explored subjectivity…

  7. Case Study - Propane Bakery Delivery Step Vans

    Energy Technology Data Exchange (ETDEWEB)

    Laughlin, M.; Burnham, A.

    2016-04-01

    A switch to propane from diesel by a major Midwest bakery fleet showed promising results, including a significant displacement of petroleum, a drop in greenhouse gases and a fuel cost savings of seven cents per mile, according to a study recently completed by the U.S. Department of Energy's Argonne National Laboratory for the Clean Cities program.

  8. Effective ABE Programming: Nine Case Studies.

    Science.gov (United States)

    Sjogren, Douglas; Jacobson, Larry

    The document presents an indepth study of nine selected exemplary adult basic education (ABE) programs in Region 8: Volunteers Clearing House, Fort Collins, Colorado; Utah Navajo Development Council, Blanding, Utah; Adult Education Tutorial Program, Denver, Colorado; Project SAVE, Lemmon, South Dakota; Gates Rubber Company, Denver, Colorado;…

  9. Responding to the Increased Needs of College Students: A Case Study of Case Management

    Science.gov (United States)

    Shelesky, Kristin; Weatherford, Ryan D.; Silbert, Janelle

    2016-01-01

    The psychological needs of college students lead to overwhelming demand on college counseling centers' resources. In this article, we review models of case management in Higher Education including the administrative, behavioral intervention, and counseling center models. We also present a case study of the 3-year development of a counseling center…

  10. Corporate Social Responsibility : A comparative case study of three companies

    OpenAIRE

    Fadel, Dennis; Dahl, Emil

    2013-01-01

    The main purpose of this thesis is to study why the chosen case companies, Atlas Copco, Sandvik and Alfa Laval engage in CSR activities, with a secondary purpose of investigating how the aformentioned case companies has executed their engagement in CSR and what their present focus is. Our empirical findings suggest that the case companies have similar motives and approaches to CSR engagement. Whereas their main motivation for CSR engagement derives from a concern of legitimacy to their invest...

  11. Verification of multi-proxy paleoclimatic studies: a case study

    Science.gov (United States)

    McIntyre, S.; McKitrick, R.

    2004-12-01

    ,000 sets of 70 red noise series modeled through fractional difference models to have the same red noise persistence as the critical North American AD1400 tree ring network. These calculations regularly resulted in "hockey-stick" shaped PC1s with sharp inflections at the start of the 20th century. We then modeled the resulting 10,000 PC1s against NH temperature and found that the 99 percent RE significance level was 0.59. By this benchmark, the reported RE statistic (0.51) in MBH98 for the AD1400 step lacks statistical significance. Most dendroclimatic reconstructions also provide statistics other than an RE statistic, including R2 and Coefficient of Efficiency, but MBH98 does not and the authors have refused to provide supporting data from which the statistics can be calculated. In our emulations of their calculations, we have been unable to replicate anything close to the reported RE results other than through re-tuning, a procedure not described in MBH98. With a re-tuning step, for the critical AD1400 step, we have obtained an RE of 0.46, but with an R2 of only 0.02 and a CE of minus 0.26, all of which lack statistical significance. This case study illustrates for extreme caution in basing public policy on articles, such as MBH98, whose claims cannot be verified.

  12. Notion of Identification: A Philosophical Case Study

    Directory of Open Access Journals (Sweden)

    Arto Mutanen

    2016-09-01

    Full Text Available Human life should be good life in the real world which is not merely a function of objective facts but also a function of subjective factors like hopes, fears, interests, etc. Goodness, or excellence, is an ethical notion. The factors of good life cannot be identified solely by using the so-called factual (descriptive methods of identification. This means that the identification cannot be fully “objective” or fully “public”. Furthermore, there is a need for other methods of identification that also take into account certain “subjective” aspects of the object of identification. Following Jaakko Hintikka we call these methods contextual (perspectival methods of identification. Here ethics is not a set of ethical rules but rather the practical study of human life. How should we live our unique life? A philosophical-conceptual study is thus practical for this purpose. This is what Aristotle called practical wisdom (phronēsis.

  13. A Case Study of Canadian Media Education

    OpenAIRE

    Clarence T. K. Chu

    2005-01-01

    This article uses bibliometric analysis to study the evaluation of journals and researchers in the field of library and information science in Taiwan. For journal evaluation, the results show no statistically significant difference between the rankings of the citations cited by top LIS journals and by THCI journals. This suggests that the citation numbers of top LIS journals can be used to evaluate all the LIS journals. The results also show that the relationship between the rankings of JCR L...

  14. Measuring financial performance : a case study

    OpenAIRE

    Gjesdal, Frøystein

    2001-01-01

    This paper studies long-term financial performance at the firm level. Fundamentally financial performance measurement is capital budgeting (or valuation) done ex post; expected cash flows and terminal values are replaced by realized or re-estimated flows and/or values. Beginning values may be derived from acquisition costs, opportunity costs or present (market) values at the start of the period. Similar choices must be faced with respect to terminal values. The interpretation of the performan...

  15. An exploration study of violence: Mexican case

    OpenAIRE

    Pedro Isnardo De la Cruz; Javier Carreón Guillén

    2013-01-01

    El documento explora, desde la perspectiva sociológica, politológica y psicológica, el estado del arte en el estudio de la violencia, y aborda la estrategia gubernamental de México en su versión asociada al narcotráfico. | The paper explores, from a sociological, political and psychological perspective, the state of the art in the study of violence, addressing the government's strategy in Mexico in the version associated with drug trafficking.

  16. Ossiculoplasty: A Prospective Study of 80 Cases

    Directory of Open Access Journals (Sweden)

    Shrinivas Shripatrao Chavan

    2014-07-01

    Full Text Available Introduction: The use of ossicular graft material in ossicular chain reconstruction has significantly improved hearing results hearing after tympanoplasty and tympanomastoid surgery for chronic otitis media. Today, otologists have a wide array of tools from which to choose, but may find it difficult to know which middle ear implant works best.   Materials and Methods: A prospective study of 80 patients who underwent ossiculoplasty was performed in the ear, nose, and throat (ENT department at a tertiary health care facility from 2011 to 2013. Patients with chronic suppurative otitis media with an air-bone gap (ABG of >25 dB with ossicular involvement were included in the study. Total ossicular replacement prosthesis (TORP, partial ossicular replacement prosthesis (PORP, and refashioned incus were used. Success was defined as ABG   Results: The majority patients were of middle age with moderate conductive hearing loss. Incus was the most susceptible ossicle. Overall success rate in this study was 80.0% with an average change of 15.76 dB in ABG.   Conclusion:  With continuing advances in our understanding of middle ear mechanics, the results of ossiculoplasty are improving and results can be very rewarding in experienced hands. Severity of preoperative ear discharge, preoperative mastoid cellularity, presence of disease, and surgical procedure proved to be significant prognostic factors. Autograft incus and PORP fared better when the malleus handle was present while TORP gave better results when the malleus handle was eroded.

  17. Return migration from Australia: a case study.

    Science.gov (United States)

    Lukomskyj, O; Richards, P

    1986-09-01

    "The study investigates the departure from Australia of former settlers who arrived during the 1980 calendar year. The 1980 settler arrival cohort [consists] of 75,167 visaed migrants.... The study has three main aims: (i) to analyse departures from Australia of the 1980 settler arrival cohort with a view to gauging the success of Australia's immigration program in retaining settlers; (ii) to examine the retention rates of settlers with respect to characteristics...including age, sex, marital status, country of last residence, and settler eligibility category; and (iii) to consider implications of the findings." Australia's present immigration policy is discussed, previous research on return migration from Australia is summarized, and a detailed analysis of the departure data is presented. "This study found that by August 1984, 12.4 per cent of non-refugee settlers who arrived in Australia during 1980 had departed permanently but that only 0.6 per cent of the 1980 refugee cohort had done so." These figures represent a decline in immigrant departure rates since the 1960s and early 1970s. Small differences in departure rates by place of birth, age, and marital status, which may have demographic consequences if sustained over time, are noted. (SUMMARY IN FRE AND SPA)

  18. Ossiculoplasty: A Prospective Study of 80 Cases

    Directory of Open Access Journals (Sweden)

    Shrinivas Shripatrao Chavan

    2014-07-01

    Full Text Available Introduction: The use of ossicular graft material in ossicular chain reconstruction has significantly improved hearing results hearing after tympanoplasty and tympanomastoid surgery for chronic otitis media. Today, otologists have a wide array of tools from which to choose, but may find it difficult to know which middle ear implant works best.   Materials and Methods: A prospective study of 80 patients who underwent ossiculoplasty was performed in the ear, nose, and throat (ENT department at a tertiary health care facility from 2011 to 2013. Patients with chronic suppurative otitis media with an air-bone gap (ABG of >25 dB with ossicular involvement were included in the study. Total ossicular replacement prosthesis (TORP, partial ossicular replacement prosthesis (PORP, and refashioned incus were used. Success was defined as ABG   Results: The majority patients were of middle age with moderate conductive hearing loss. Incus was the most susceptible ossicle. Overall success rate in this study was 80.0% with an average change of 15.76 dB in ABG.   Conclusion:  With continuing advances in our understanding of middle ear mechanics, the results of ossiculoplasty are improving and results can be very rewarding in experienced hands. Severity of preoperative ear discharge, preoperative mastoid cellularity, presence of disease, and surgical procedure proved to be significant prognostic factors. Autograft incus and PORP fared better when the malleus handle was present while TORP gave better results when the malleus handle was eroded.  

  19. Management case study: Tampa Bay, Florida

    Science.gov (United States)

    Morrison, Gerold; Greening, Holly; Yates, Kimberly K.; Wolanski, Eric; McLusky, Donald S.

    2011-01-01

    Tampa Bay, Florida, USA, is a shallow, subtropical estuary that experienced severe cultural eutrophication between the 1940s and 1980s, a period when the human population of its watershed quadrupled. In response, citizen action led to the formation of a public- and private-sector partnership (the Tampa Bay Estuary Program), which adopted a number of management objectives to support the restoration and protection of the bay’s living resources. These included numeric chlorophyll a and water-clarity targets, as well as long-term goals addressing the spatial extent of seagrasses and other selected habitat types, to support estuarine-dependent faunal guilds. Over the past three decades, nitrogen controls involving sources such as wastewater treatment plants, stormwater conveyance systems, fertilizer manufacturing and shipping operations, and power plants have been undertaken to meet these and other management objectives. Cumulatively, these controls have resulted in a 60% reduction in annual total nitrogen (TN) loads relative to earlier worse-case (latter 1970s) conditions. As a result, annual water-clarity and chlorophyll a targets are currently met in most years, and seagrass cover measured in 2008 was the highest recorded since 1950. Factors that have contributed to the observed improvements in Tampa Bay over the past several decades include the following: (1) Development of numeric, science-based water-quality targets to meet a long-term goal of restoring seagrass acreage to 1950s levels. Empirical and mechanistic models found that annual average chlorophyll a concentrations were a primary manageable factor affecting light attenuation. The models also quantified relationships between TN loads, chlorophyll a concentrations, light attenuation, and fluctuations in seagrass cover. The availability of long-term monitoring data, and a systematic process for using the data to evaluate the effectiveness of management actions, has allowed managers to track progress and

  20. Assessment of Correspondent Banks Case Study

    Directory of Open Access Journals (Sweden)

    Abeer F.A.A. Abbadi

    2011-01-01

    Full Text Available Problem statement: This study aims at evaluating corresponding banks in Jordan. Characterizing the goals, instruments and profitability under unfavorable conditions of financial setbacks and unfair competition among banks. Focuses on the feasibility and profitability of Philadelphia Investment Bank in its international trade via its Correspondent banks. Approach: Problems and setbacks shall be screened out; reasoned and appropriate optimal recommendations are to be presented. Results: The study followed the analytical approach and depended on “History Documents” and “In depth Interview” techniques and puts a major emphasis on the fact that correspondent banking has become an essential cornerstone of international business amid the new era of world trade, globalization, external competition and cartels from the major opponents to Jordanian Banks, the main conclusion is realized the importance of correspondent banks in the international trade, so Philadelphia bank benefited from correspondent banks for the cheap cost of market entry and services were tailored to the scale of required locale. But there was no big investment in staff facilities. And there are setbacks in dealing with correspondent banks, such as fund delay in reaching destinations on time. Moreover, Jordanian banks have suffered in general from these correspondent banks because they deal with these correspondent banks individually. Conclusion/Recommendations: The recommendation of the study is, it is the time to consider solidification and forming one financial block, or a sort of cartel and face these correspondent banks in one unit. They are also called for developing collective strategies. Small banks should merge and form huge capital blocks. Another strategy is that Jordanian banks should minimize the reliance on foreign banks and should develop their own, by establishing international branches abroad to help financing their international activities.

  1. Temporomandibular disorders. A case-control study

    OpenAIRE

    Poveda-Roda, Rafael; Bagán, Jose V.; Sanchis, Jose M.; Carbonell, Enrique

    2012-01-01

    Objective: To compare the risk factors and clinical manifestations of patients with temporomandibular disorders (TMDs) diagnosed according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) (axis I) versus an age and gender matched control group. Study Design: A total of 162 patients explored according to the RDC/TMD (mean age 40.6±18.8 years, range 7-90; 11.1% males and 88.9% females) were compared with 119 controls, measuring differences in TMD risk factors (sleep...

  2. Towards Sustainable Building: Case Study on Romania

    Directory of Open Access Journals (Sweden)

    Ana Maria Marinoiu

    2016-06-01

    Full Text Available The purpose of this article is to analyze the actual situation of the green buildings in our country but also the degree in which the real estate developers are involved in such projects. The study was conducted by combining a wide variety of sources, such as regulations, position papers, as well as articles and research reports. The results of the research show that the market for green buildings in Romania is at an early stage of development however, there are prerequisites for its development. In the future, green building will become the standard in the construction industry.

  3. A STUDY OF EPILEPTIC PSYCHOSES - 150 CASES

    OpenAIRE

    Swamy, H. Satyanarayana; Mallikarjunaiah, M.; Bhatti, Ranbir S.; Kaliaperumal, V.G.

    1986-01-01

    SUMMARY One hundred and fifty patients of epileptic psychosis, registered over a period of five years in neuropsychiatry clinics at NIMHANS were studied. Patients with organic causes which may produce both epilepsy and psychosis were excluded. The epileptic psychosis ratio to epilepsy was 1:23 and the epileptic psychosis ratio to psychosis was 1:75. The mean age at the onset of epilepsy was 19.4 years, while the mean age at the onset of psychosis was 29 years and thus the mean duration of epi...

  4. A case study, Bagnoli: a difficult transition

    Directory of Open Access Journals (Sweden)

    Maria Antonietta Selvaggio

    2015-01-01

    In this research work we intend to verify how a particular physical-spatial dimension has influenced the social relations and the same identities of the people and their “community”, how we can delineate the perception and the performance of a urban transformation largely failed, and which contribution the citizens of Bagnoli can give to the urban design through their own imaginary and meanings they ascribe to their environment (Lynch 1960. In this sense, the study aim at giving a contribution to the participative practice, that up to now is out of the transition dynamics.

  5. Environmental reference materials methods and case studies

    DEFF Research Database (Denmark)

    Schramm-Nielsen, Karina Edith

    1998-01-01

    evaluation of certification data. The plots illustrate consistency between replicate measurements on samples from a batch of reference material, carried out in a number of laboratories according to a staggered nested design. The development of a reference material is illustrated by a series of experiments......This thesis introduces the reader to the concept of chemical environmental reference materials and their role in traceability and chemical analyses of the environment. A number of models and principles from the literature are described. Some suggestions are made as to how stability studies can...

  6. Case study of establishing a clean production

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yong Kun; Nam, Yoon Mi [Korea Environment Institute, Seoul (Korea)

    1998-12-01

    This study was implemented to derive suggestions for improving policies in Korea through the examination and analysis on the present policies related to the clean production and its establishment in enterprises. The characters of concept on clean production presented in pollution prevention, waste minimization, zero emission, environmental friendly design, and industrial ecology were analyzed and the mechanism for implementing clean production and government policy were arranged comprehensively. The related policies of major countries with international organizations including UNEP (United Nations Environment Program) and EU (European Union) were reviewed and compared to those of Korea to propose future policy plan. 73 refs., 3 figs., 30 tabs.

  7. Case Study on Printed Matter in Denmark

    DEFF Research Database (Denmark)

    Larsen, Henrik Fred

    2012-01-01

    2006. A major part of the work has been mapping the presence of chemicals, which are the potential candidates for substitution (e.g., PBT, CMR, vPvB, EDS). The mapping comprises a combination of a literature study and an investigation of the actual (2007) presence of candidate substances at 15 Danish...... printing houses including the examination of almost 900 MSDSs (i.e., products). Furthermore, a focused search in the Danish Product Register has been included. More than 200 of the mapped substances are candidates for substitution according to Danish legislation (List of Undesirable Substances) and about...

  8. Qualitative methodology in a psychoanalytic single case study

    DEFF Research Database (Denmark)

    Grünbaum, Liselotte

    This study concerns the systematic integration of qualitative research strategies in a psychoanalytic single case study of a child who had suffered early abuse and neglect. A systematic exploration of core features of the therapeutic relationship was carried out, possible links between such core...... with Interpretational Phenomenological Analysis were applied on recorded session notes and other case-file material from a concluded child psychotherapy case as well as on transcripts from follow-up interviews with the child’s birth and foster parents. The case material analyzed in three steps; principles...... for transparent selection developed: 1) Inductive exploration highlighting core object relationship themes in the first 24 therapy sessions. 2) Predefined manifestations of these themes systematically studied in case file reports from various informants about the child’s infancy, daily life, at end of therapy...

  9. Economics, Wildlife Tourism and Conservation: Three Case Studies

    OpenAIRE

    Clement A. Tisdell; Wilson, Clevo

    2004-01-01

    SUMMARY This report presents the results of an economics component of the National Interdisciplinary Project (NIP) on wildlife tourism in Australia. Objectives of Study The main objectives of the study were: • to outline and assess the role that economics can play in the valuation and management of wildlife-based tourism; • to undertake appropriate case studies to highlight the value of economics and its limits in assessing wildlife tourism in each case; • given the importance of nature conse...

  10. Factors determining retail banks performance : case study Ubank / Buhle Mdakane

    OpenAIRE

    Mdakane, Buhle

    2012-01-01

    The study is a case study and it investigates the factors that determine the performance of retail banks in South Africa, and follows a case study approach in which Ubank is the focus. The purpose is to rank the identified factors in their order of importance for management's focus on improving the bank's performance. Performance is examined in terms of the bank's profitability and growth. This research utilizes secondary data analysis. The quantitative method is used by critic...

  11. Case Study - Propane School Bus Fleets

    Energy Technology Data Exchange (ETDEWEB)

    Laughlin, M; Burnham, A.

    2014-08-31

    As part of the U.S. Department of Energy’s (DOE’s) effort to deploy transportation technologies that reduce U.S. dependence on imported petroleum, this study examines five school districts, one in Virginia and four in Texas, successful use of propane school buses. These school districts used school buses equipped with the newly developed liquid propane injection system that improves vehicle performance. Some of the school districts in this study saved nearly 50% on a cost per mile basis for fuel and maintenance relative to diesel. Using Argonne National Laboratory’s Alternative Fuel Life-Cycle Environmental and Economic Transportation (AFLEET) Tool developed for the DOE’s Clean Cities program to help Clean Cities stakeholders estimate petroleum use, greenhouse gas (GHG) emissions, air pollutant emissions and cost of ownership of light-duty and heavy-duty vehicles, the results showed payback period ranges from 3—8 years, recouping the incremental cost of the vehicles and infrastructure. Overall, fuel economy for these propane vehicles is close to that of displaced diesel vehicles, on an energy-equivalent basis. In addition, the 110 propane buses examined demonstrated petroleum displacement, 212,000 diesel gallon equivalents per year, and GHG benefits of 770 tons per year.

  12. Cirrus cloud iridescence: a rare case study

    Science.gov (United States)

    Sassen, Kenneth

    2003-01-01

    On the evening of 25 November 1998, a cirrus cloud revealing the pastel colors of the iridescence phenomenon was photographed and studied by a polarization lidar system at the University of Utah Facility for Atmospheric Remote Sensing (FARS). The diffraction of sunlight falling on relatively minute cloud particles, which display spatial gradients in size, is the cause of iridescence. According to the 14-year study of midlatitude cirrus clouds at FARS, cirrus rarely produce even poor iridescent patches, making this particularly long-lived and vivid occurrence unique. In this unusually high (13.2-14.4-km) and cold (-69.7 ° to -75.5°) tropopause-topped cirrus cloud, iridescence was noted from ~6.0° to ~13.5° from the Sun. On the basis of simple diffraction theory, this indicates the presence of particles of 2.5-5.5-μm effective diameter. The linear depolarization ratios of δ = 0.5 measured by the lidar verify that the cloud particles were nonspherical ice crystals. The demonstration that ice clouds can generate iridescence has led to the conclusion that iridescence is rarely seen in midlatitude cirrus clouds because populations of such small particles do not exist for long in the presence of the relatively high water-vapor supersaturations needed for ice-particle nucleation.

  13. A Psychophysiological Case Study of Orchestra Conductors.

    Science.gov (United States)

    Jaque, S Victoria; Karamanukyan, Isabel H; Thomson, Paula

    2015-12-01

    The psychological and physiological effects of performance were investigated in two professional orchestral conductors, with data collected prior to, during, and after a rehearsal and a public performance. The participants were given a battery of psychological self-report tests (anxiety, dissociation, health inventory, fantasy proneness, shame, and flow). Ambulatory physiological monitoring (Vivometric LifeShirt® system) was conducted during both a rehearsal and public performance to gather information about the autonomic nervous system and heart rate variability (HRV). One conductor had a history of asthma and anxiety, and the second conductor had coronary artery disease. The results revealed within-subject and between-subject differences in autonomic nervous system responses and HRV during several conditions (pre-performance rest, stair-climbing, rehearsal, and performance). Based on heart rate, the physiological demands of professional conducting are reflective of work intensities considered "hard." Both conductors experienced high flow states. Anxiety and coronary artery disease may have attenuated HRV resilience in this study. It is recommended that noninvasive methods be implemented to assess cardiac autonomic activity in professional conductors, particularly during engagement in their professional activities. The findings suggest a need to further study anxiety, respiratory conditions, and cardiovascular risks for conductors. PMID:26614972

  14. Neonatal asphyxia: A study of 210 cases

    Directory of Open Access Journals (Sweden)

    Hülya Üzel

    2012-06-01

    Full Text Available Objectives: Perinatal asphyxia remains an importantcause of neonatal morbidity and mortality. The aim of thisstudy was to investigate antenatal, natal, and postnatalrisk factors of neonatal asphyxia, relationship with knownrisk factors and stage of Sarnat and Sarnat scores, theeffect of risk factors on hospital discharge and survival forneonates with perinatal asphyxia.Materials and methods: In this study, we retrospectivelyanalyzed the hospital records of 210 patients diagnosedas perinatal asphyxia. The patients’ demographic characteristics,antepartum, intrapartum, and postpartum riskfactors and Sarnat and Sarnat clinical staging criteria ofnewborns were analyzed.Results: The risk factors for asphyxia were detectedantepartum period in 67.7% of newborns, intrapartum in91% and potpartum in of 29.5% of neonates. When caseswere examined according to the studied years, perinatalasphyxia ratio was the most frequent in 2007 as 28.1%.With a decline over the years, frequency dropped to %21in 2010. The number of patients with stage 3 and mortalityrate were significantly decreased over the years (p<0.05.Conclusions: Less preventable intrapartum causes ofbirth asphyxia are seen more frequently. Early detectionof risk factors together with appropriate prenatal, nataland postnatal care provision, reduced emergency caesareansections and will decrease considerably decreasefrequency of perinatal asphyxia. We think that followingup neonates who needed intensive care in neonatal unitssufficiently equipped will decrease complications due toasphyxia. J Clin Exp Invest 2012; 3(2: 194-198

  15. Calcium, snails, and birds: a case study

    Directory of Open Access Journals (Sweden)

    R. Mänd

    2000-10-01

    Full Text Available Recent studies have shown that wild birds breeding in acidified areas have difficulties with obtaining sufficient calcium for their eggshells, and that the cause of it is the shortage of land snails. Many birds have to search for Ca-rich snail shells on a daily basis during egg production. Molluscs depend on litter calcium, which has decreased due to acidification of the environment. Calcium limitation may be a widespread phenomenon also in non-acidified, naturally Ca-poor areas. The problem is that while in the latter areas the time for development of specific adaptations may have been sufficient, then in acidified areas, on the contrary, calcium shortage is a recent phenomenon. Therefore, since the extent of calcium limitation in non-acidified areas is hard to derive from observational data, experimental approach is needed. We provide experimental evidence that specific calcium deficit does affect reproductive traits also in the birds breeding in naturally base-poor habitats. Our study was conducted in a heterogeneous woodland area in Estonia containing deciduous forest patches as well as base-poor pine forest with low snail abundance. Ca supplementation, using snail shell and chicken eggshell fragments, was carried out for pied flycatchers and great tits. Extra calcium affected positively several reproductive traits like egg volume and eggshell thickness, start of breeding, and fledglings’ parameters. The negative relationship between calcium availability and lay-date suggests that birds adjust their breeding tactics to conditions of Ca deficiency, for example, by postponing laying.

  16. Cartography and Population Geography as Current Events: A Case Study

    Science.gov (United States)

    Comenetz, Joshua

    2003-01-01

    The Sanders housing lawsuit in Pennsylvania provides a case study of how to incorporate current events into the teaching of cartography or population geography at the high school or college level. Settlement of the Sanders case resulted in the release of information about the segregation of public housing by race in the Pittsburgh area. The issues…

  17. Evaluating a Tacit Knowledge Sharing Initiative: A Case Study

    Science.gov (United States)

    Gubbins, Claire; Corrigan, Siobhan; Garavan, Thomas N.; O'Connor, Christy; Leahy, Damien; Long, David; Murphy, Eamonn

    2012-01-01

    Purpose: This paper aims to present a case study illustrating the issues involved in the tacit knowledge conversion process and to determine whether such conversion delivers value to the organisation in terms of business value and return on investment (ROI). Design/methodology/approach: A single-case multiple baseline participants experimental…

  18. Case Study Report #17. Franklin and Andrea White Deer.

    Science.gov (United States)

    Myers, Douglas D.; And Others

    This document presents one in a series of twenty-three case studies derived from in-depth interviews using a sampling of former participants in the Mountain-Plains program, a residential, family-based education program developed to improve the economic potential and lifestyle of selected student families in a six-state area. Each case study…

  19. Identification of Ambiguity in the Case Study Research Typology

    DEFF Research Database (Denmark)

    Grünbaum, Niels Nolsøe

    2015-01-01

    The purpose of this four volume collection is to provide an accessible selection of the best writing on case study in the English language internationally. Such a collection is timely and highly relevant to students, researchers and academics in higher education, especially when the case illustra...

  20. PEM Electrolysis H2A Production Case Study Documentation

    Energy Technology Data Exchange (ETDEWEB)

    James, Brian [Strategic Analysis Inc. (SA), Arlington, Virginia; Colella, Whitney [Strategic Analysis Inc. (SA), Arlington, Virginia; Moton, Jennie [Strategic Analysis Inc. (SA), Arlington, Virginia; Saur, G. [Strategic Analysis Inc. (SA), Arlington, Virginia; Ramsden, T. [Strategic Analysis Inc. (SA), Arlington, Virginia

    2013-12-31

    This report documents the development of four DOE Hydrogen Analysis (H2A) case studies for polymer electrolyte membrane (PEM) electrolysis. The four cases characterize PEM electrolyzer technology for two hydrogen production plant sizes (Forecourt and Central) and for two technology development time horizons (Current and Future).

  1. Case Studies of Uncommon and Rare Headache Disorders.

    Science.gov (United States)

    Evans, Randolph W

    2016-08-01

    The following 6 case studies are presented: a 12-day migraine with recurring aura?; a migraineur with a new constant headache for 1 month; an orthostatic headache; a unilateral headache; migraine with aura and limb pain without headache; and nocturnal headaches. These cases illustrate the fascinating diversity and challenges of primary and secondary headaches that neurologists commonly encounter. PMID:27445245

  2. Leadership Analysis in K-12 Case Study: Superintendent's Hiring Dilemma

    Science.gov (United States)

    Alsobaie, Mohammed Fahad

    2016-01-01

    This paper will seek to analyze of the case "Superintendent's Hiring Dilemma" by Hoy and Tarter (2004) using multiple leadership perspectives. The last section of this analysis of the case study will provide the most effective leadership recommendations for the key players.

  3. Regional heritage preservation planning :an examination through case study analysis

    OpenAIRE

    Hardy, Karen J.

    1993-01-01

    Cultural preservation efforts have evolved from traditional, site specific projects administered by a single agency, to regional, multi-jurisdictional projects administered by a cooperative partnership. The projects administered cooperative partnerships are a recent phenomena and are often termed heritage preservation projects. An analysis of the evolution of cultural preservation efforts is undertaken through historical and case study research. The selected cases are ...

  4. Case studies in intelligent computing achievements and trends

    CERN Document Server

    Issac, Biju

    2014-01-01

    Although the field of intelligent systems has grown rapidly in recent years, there has been a need for a book that supplies a timely and accessible understanding of this important technology. Filling this need, Case Studies in Intelligent Computing: Achievements and Trends provides an up-to-date introduction to intelligent systems.This edited book captures the state of the art in intelligent computing research through case studies that examine recent developments, developmental tools, programming, and approaches related to artificial intelligence (AI). The case studies illustrate successful ma

  5. Single case studies as a means for developing psychological theories.

    Science.gov (United States)

    Skvortsov, Anatoliy; Romashchuk, Alexander

    2015-12-01

    The Socratic function of single case studies (SCSs) is described in its relation to the problem of scientific theory development. Contrary to the traditional point of view, the single case study is not a demonstration or verification of theoretical concepts, but a method of their generation and opportunity for analysis of their interrelations. Considering the case study from the perspective of the Socratic function brings to light important conclusions about the ecological validity of theory development. The essential features of the Socratic function are illustrated using the example of the famous Romantic Essays of Alexandr Luria. PMID:26663629

  6. Interactive verification of Markov chains: Two distributed protocol case studies

    Directory of Open Access Journals (Sweden)

    Johannes Hölzl

    2012-12-01

    Full Text Available Probabilistic model checkers like PRISM only check probabilistic systems of a fixed size. To guarantee the desired properties for an arbitrary size, mathematical analysis is necessary. We show for two case studies how this can be done in the interactive proof assistant Isabelle/HOL. The first case study is a detailed description of how we verified properties of the ZeroConf protocol, a decentral address allocation protocol. The second case study shows the more involved verification of anonymity properties of the Crowds protocol, an anonymizing protocol.

  7. Active learning of statistics: a case study

    Directory of Open Access Journals (Sweden)

    Erica J. Morris

    2000-12-01

    Full Text Available Students studying psychology or a social science have to take courses in statistics, but students often experience difficulties in learning statistical concepts and techniques. Indeed, there is a body of interdisciplinary research that indicates that students tend to have confusions and difficulties with a variety of topics in statistics (Garfield and Ahlgren, 1988; Shaughnessy, 1992. It has been found that students hold misconceptions relating to fundamental statistical concepts, such as the mean and correlation (Mevarech, 1983; Morris, 1997. Research in computer-based learning has looked at how the computer can be used effectively to address students' statistical misconceptions and help students come to understand key statistical ideas (Cumming and Thomason, 1995; Morris, 1998.

  8. Mapping Regional Drought Vulnerability: a Case Study

    Science.gov (United States)

    Karamouz, M.; Zeynolabedin, A.; Olyaei, M. A.

    2015-12-01

    Drought is among the natural disaster that causes damages and affects many people's life in many part of the world including in Iran. Recently, some factors such as climate variability and the impact of climate change have influenced drought frequency and intensity in many parts of the world. Drought can be divided into four categories of meteorological, hydrological, agricultural and social-economic. In meteorological the important feature is lack of rainfall. In hydrological drought river flows and dam storage are considered. Lack of soil moisture is the key factor in agricultural droughts while in social-economic type of drought the relation between supply and demand and social-economic damages due to water deficiency is studied. While the first three types relates to the lack of some hydrological characteristics, social-economic type of drought is actually the consequence of other types expressed in monetary values. Many indices are used in assessing drought; each has its own advantages and disadvantages and can be used for specific types of drought. Therefore knowing the types of drought can provide a better understanding of shortages and their characteristics. Drought vulnerability is a concept which shows the likelihood of damages from hazard in a particular place by focusing on the system status prior to the disaster. Drought vulnerability has been viewed as a potential for losses in the region due to water deficiency at the time of drought. In this study the application of vulnerability concept in drought management in East Azarbaijan province in Iran is investigated by providing vulnerability maps which demonstrates spatial characteristics of drought vulnerability. In the first step, certain governing parameters in drought analysis such as precipitation, temperature, land use, topography, solar radiation and ground water elevation have been investigated in the region. They are described in details and calculated in suitable time series. Vulnerabilities

  9. biochemical and hormonal studies in obese cases

    International Nuclear Information System (INIS)

    The present study was carried out on a total number of 116 obese and 23 non-obese control females. Obesity was assessed mainly by body mass index (BMI). Other skinfold thickness e.g. triceps, subscapular, suprailiac, as parameters of obesity assessment were determined in some obese patients. The degree of obesity was assessed by BMI and categorized as follows: i- Mild obesity, BMI=25-30 Kg/m2. ii-Moderate obesity, BMI=31-35 kg/m2. iii-severe obesity, BMI= above 35 kg/m2. Type of fat distribution was assessed by waist/hip circumference ratio (w/H) as :- i-gynoid (lower body segment obesity). (≤ 0.81) i i- android (upper body segment obesity). (≥0.82)

  10. Case study on ground water flow (8)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-02-01

    The report comprises research activities made in fiscal year 1997 under the contract of Japan Nuclear Fuel Cycle Development Center and the main items are: (1) Evaluation of water permeability through discontinuous hard bedrock in deep strata in relevant with underground disposal of radioactive wastes, (2) Three dimensional analysis of permeated water in bedrock, including flow analysis in T ono district using neuro-network and modification of Evaporation Logging System, (3) Development of hydraulic tests and necessary equipment applicable to measurements of complex dielectric constants of contaminated soils using FUDR-V method, this giving information on soil component materials, (4) Investigation methods and modeling of hydraulics in deep strata, (5) Geological study of ground water using environmental isotopes such as {sup 14}C, {sup 36}Cl and {sup 4}He, particularly measurement of ages of ground water using an accelerator-mass spectrometer, and (6) Re-submerging phenomena affecting the long-term geological stability. (S. Ohno)

  11. Urban pest management. A Madrid case study

    Directory of Open Access Journals (Sweden)

    Ibon Tamayo Uria

    2013-06-01

    Full Text Available Citizens’ reports of sightings of undesirable animals are a common component of pest control programmes in a city. For this reason, local authorities tend to develop procedures for the capture and analysis of the resulting data sets based on these reported sightings. These procedures in turn contribute to the development of other initiatives aimed at improving public health conditions. The study presented here focuses on the methodology designed and implemented by the Madrid City Council for controlling and managing the presence of urban pests.The long experience (over 100 years of the City Council and its commitment to the incorporation of new technologies have allowed a number of important lessons to be learnt in pest control and management, which may be useful as a guide and model for cities where public health services have not yet incorporated these methods.

  12. Struggling doctors in specialist training: a case control study

    DEFF Research Database (Denmark)

    O'Neill, Lotte; Norberg, Karen; Thomsen, Maria;

    health professionals, and as the gold standard for educational supervision.2,4-6 Therefore, the aim of this study was to examine: if strugglers in specialist training (cases) tended to struggle already in medical school or not compared to controls (non-strugglers), and which performance indicators during...... not identified as cases in the case extraction period. We aimed at a case-control ratio of 1:4 and intend to match on graduation year. Ten different performance measures relating to medical school admission, first year performance and overall program performances will be examined, such as: pre-university exam...

  13. Two Case Studies Related to Total Knee Arthroplasty

    Science.gov (United States)

    Hale, David

    2016-01-01

    Objectives: Report on Two Case Studies related to Total Knee Arthroplasty Previously Discussed by AKS Members Methods: Case Series Case 1: A 76 year old woman requiring a right total knee replacement in the presence of marked dystrophic calcification affecting the quadriceps tendon on a background of having sustained a post operative quadriceps tendon rupture post left TKR in 2013 Case 2: Management issues related to performing a TKR in a 80 year old woman with a possible past history of TB affecting the joint Conclusion: Both procedures went smoothly and particularly as advice was given by AKS members, these are presented largely for feedback.

  14. The Case of the "Tainted" Taco Shells: A Case Study on Genetically Modified Foods

    Science.gov (United States)

    Taylor, Ann T. S.

    2004-01-01

    This case study introduces students to the use of genetically modified foods. Students learn how genetically modified plants are made, and then they read primary literature papers to evaluate the environmental, economic, and health issues. (Contains 2 figures.)

  15. SCMAI Case Report: Librarians in Faculty Unions--A Case Study.

    Science.gov (United States)

    Marko, Lynn

    1979-01-01

    The problems of librarians in faculty unions in relation to status, salary, and salary calculation are covered in this case study brought before the American Library Association Staff Committee on Mediation, Arbitration, and Inquiry (SCMAI) in 1977. (Author/MBR)

  16. Exploring Arabidopsis thaliana Root Endophytes via Single-Cell Genomics

    Energy Technology Data Exchange (ETDEWEB)

    Lundberg, Derek; Woyke, Tanja; Tringe, Susannah; Dangl, Jeff

    2014-03-19

    Land plants grow in association with microbial communities both on their surfaces and inside the plant (endophytes). The relationships between microbes and their host can vary from pathogenic to mutualistic. Colonization of the endophyte compartment occurs in the presence of a sophisticated plant immune system, implying finely tuned discrimination of pathogens from mutualists and commensals. Despite the importance of the microbiome to the plant, relatively little is known about the specific interactions between plants and microbes, especially in the case of endophytes. The vast majority of microbes have not been grown in the lab, and thus one of the few ways of studying them is by examining their DNA. Although metagenomics is a powerful tool for examining microbial communities, its application to endophyte samples is technically difficult due to the presence of large amounts of host plant DNA in the sample. One method to address these difficulties is single-cell genomics where a single microbial cell is isolated from a sample, lysed, and its genome amplified by multiple displacement amplification (MDA) to produce enough DNA for genome sequencing. This produces a single-cell amplified genome (SAG). We have applied this technology to study the endophytic microbes in Arabidopsis thaliana roots. Extensive 16S gene profiling of the microbial communities in the roots of multiple inbred A. thaliana strains has identified 164 OTUs as being significantly enriched in all the root endophyte samples compared to their presence in bulk soil.

  17. A parathyroid adenoma case study: Protocol review

    International Nuclear Information System (INIS)

    Full text: Technetium-99m (99mTc) Sestamibi as opposed to Thallous-201 Chloride and 99mTc Sodium Pertechnetate subtraction, has become the radiopharmaceutical of choice for detection of parathyroid adenomas. A 17-year-old female patient presented to the department for a parathyroid 99mTc Sestamibi scan to evaluate possible parathyroid adenoma/s. She was initially admitted with increasing serum Calcium levels, polyuria, abdominal pain and general malaise. The patient was injected with 900MBq of 99mTc Sestamibi, and a pinhole dynamic at a distance of 10 cm from the neck was acquired followed by a 5-minute static image at 7 cm. Single Photon Emission Computed Tomography (SPECT) was then performed on a dual-head gamma camera followed by an anterior and posterior 10-minute static image. At 3 and 5 hours post injection the 10-minute static image was repeated. This study was reported as normal with uniform uptake and washout of the tracer over the 5-hour period. An ultrasound study was performed, and it showed a lesion believed to be a parathyroid adenoma measuring 2.2 x 0.8 x 0.4 cm in size in the right upper lobe of the thyroid. A subsequent thyroid scan was performed to confirm that it was non-functioning thyroid tissue. The patient was injected with 250MBq of 99mTc Sodium Pertechnetate and scanned with a pinhole collimator at a distance of 7 cm. When the 99mTc Sestamibi and 99mTc Sodium Pertechnetate scan were viewed together, it was clear that there was excess 99mTc Sestamibi distribution on the right upper lobe of the thyroid, which washed out over time. This corresponded to the ultrasound findings and was confirmed at surgery to be a parathyroid adenoma. A 99mTc Sodium Pertechnetate scan and an ultrasound are now also routinely performed on patients presenting for 99mTc Sestamibi parathyroid scans

  18. Preventive maintenance by vibratory analysis: case study

    Directory of Open Access Journals (Sweden)

    Amal Boukili,

    2015-08-01

    Full Text Available :The majority of the industrial machine components have to satisfy to the requirements of the high quality and incessantly increasing; so the machines maintaining in good state during the production has became a fundamental point for a product or a company success. Through the measure of the predictive maintenance, it is possible to satisfy these complex requirements with success and to reduce the costs of maintenance. However, an optimization of the maintenance is realized by a continued monitoring of degradation, by way of a control system on line “On Line”, which can respond to industrial imperatives and which provides to define just the necessary at the level of interventions, “The machine can’t be serviced except if only its state requires.”For an effective maintenance, it takes precise and reliable measures. Nevertheless, the experience has shown that the vibratory measure is the most reliable parameter that gives the precociously and with a best ways the deterioration state of a turnable machine. It provides to identify the efforts as soon as they appear, before of an irreversible damage, it also provides, after analysis, to deduce the origin and to estimate the breakdown risks.In this context, a study had done inside a workshop of a phosphoric office, which adopt a continued surveillance (On-Line, in the hope of doing an optimal process of a conditional maintenance which can be developed in time toward an idealized by a vibratory indicator accomplishing satisfactory results.

  19. A Case Study in Key Measuring Software

    Directory of Open Access Journals (Sweden)

    Naeem Nematollahi

    2012-02-01

    Full Text Available In this paper, we develop and study a new algorithm to recognize and precisely measure keys for the ultimate purpose of physically duplicating them. The main challenge comes from the fact that the proposed algorithm must use a single picture of the key obtained from a regular desktop scanner without any special preparation. It does not use the special lasers, lighting systems, or camera setups commonly used for the purpose of key measuring, nor does it require that the key be placed in a precise position and orientation. Instead, we propose an algorithm that uses a wide range of image processing methods to discover all the information needed to identify the correct key blank and to find precise measures of the notches of the key shank from the single scanned image alone. Our results show that our algorithm can correctly differentiate between different key models and can measure the dents of the key with a precision of a few tenths of a millimeter.

  20. Cognitive behavioural therapy (CBT – case studies

    Directory of Open Access Journals (Sweden)

    Martyna Głuszek-Osuch

    2016-04-01

    Full Text Available The objective of the present study is to further elucitate the specifics cognitive behavioural therapy (CBT based on the treatment of 2 patients. The theoretical background of the therapy is based on the idea that the learning processes determine behaviour (behavioural therapy, acquisition and consolidation of beliefs and view of the world (cognitive therapy. The CBT is short-term (usually 12–20 weekly sessions. It assumes close links between the patient’s thoughts (about self, the world and the future and his/her emotions, behaviour and physiology. The patient’s work in between sessions consists in observation of their own thoughts, behaviours, and emotions, and introduction of changes within the scope of their thoughts and behaviours. The goal of cognitive behavioural therapy is autonomy and independence of a patient, attainment of the patient’s objectives, and remedying the most important problems of the patient. The therapist should be active, warm and empathic. Cognitive behavioural therapy is structured and active. Between sessions, the patient receives homework assignments to complete. During therapy, information is collected by experiments and verification of hypotheses. It should be emphasized that for changes to occur in the process of psychotherapy it is necessary to establish a strong therapeutic alliance.

  1. Deltoid contracture: A study of nineteen cases

    Directory of Open Access Journals (Sweden)

    Banerji Debabrata

    2008-01-01

    Full Text Available Objective: Deltoid contracture is not uncommon in India. Contractures of deltoid often do not have definite etiology. We have critically analyzed the condition as regards the etiopathogenesis and its surgical results. Materials and Methods: Nineteen patients with deltoid contracture operated between June 1990 and September 2001 were enrolled for a unicentric retrospective study. The surgery was indicated in patients with abduction deformity of more than 30° at the shoulder. The etiology of deltoid contracture was idiopathic ( n = 13 intramuscular injection in deltoid muscle ( n = 5 and blunt trauma ( n = 1. All were operated by distal release (incision near the insertion of the deltoid muscle. The average follow-up was of 9.5 years (range 6-17 years. They were evaluated based on parameters like pain, persistence of deformity, range of shoulder movements and strength of deltoid. Results: All patients recovered painless full range of shoulder motion except one. The correction of deformity was achieved in all patients and there was no loss of strength of deltoid compared to the opposite side. Histology of excised tissue showed features of chronic inflammation. The complications observed were hypertrophic scar ( n = 1, painful terminal restriction of shoulder movements ( n = 1 and prominent vertebral border of scapula ( n = 1. Conclusion: Deltoid contracture has features of chronic inflammation, and the intramuscular deltoid injection is the most incriminating factor in its etiopathogenesis. The condition can be effectively managed surgically by distal release of the deltoid muscle combined with excision of the muscular fibrotic contracture band.

  2. Case study: Natural bodybuilding contest preparation.

    Science.gov (United States)

    Kistler, Brandon M; Fitschen, Peter J; Ranadive, Sushant M; Fernhall, Bo; Wilund, Kenneth R

    2014-12-01

    The purpose of this study was to document the physiological changes that occur in a natural bodybuilder during prolonged contest preparation for a proqualifying contest. During the 26-week preparation, the athlete undertook a calorically restrictive diet with 2 days of elevated carbohydrate intake per week, increased cardiovascular (CV) training, and attempted to maintain resistance-training load. The athlete was weighed twice a week and body composition was measured monthly by DXA. At baseline and every 2 weeks following CV structure and function was measured using a combination of ultrasound, applanation tonometry, and heart rate variability (HRV). Cardiorespiratory performance was measured by VO(2)peak at baseline, 13 weeks, and 26 weeks. Body weight (88.6 to 73.3 Kg, R(2) = .99) and percent body fat (17.5 to 7.4%) were reduced during preparation. CV measurements including blood pressure (128/61 to 113/54 mmHg), brachial pulse wave velocity (7.9 to 5.8m/s), and measures of wave reflection all improved. Indexed cardiac output was reduced (2.5 to 1.8L/m(2)) primarily due to a reduction in resting heart rate (71 to 44 bpm), and despite an increase in ejection faction (57.9 to 63.9%). Assessment of HRV found a shift in the ratio of low to high frequency (209.2 to 30.9%). Absolute VO2 was minimally reduced despite weight loss resulting in an increase in relative VO2 (41.9 to 47.7 ml/Kg). In general, this prolonged contest preparation technique helped the athlete to improve body composition and resulted in positive CV changes, suggesting that this method of contest preparation appears to be effective in natural male bodybuilders. PMID:24901578

  3. Case study: Natural bodybuilding contest preparation.

    Science.gov (United States)

    Kistler, Brandon M; Fitschen, Peter J; Ranadive, Sushant M; Fernhall, Bo; Wilund, Kenneth R

    2014-12-01

    The purpose of this study was to document the physiological changes that occur in a natural bodybuilder during prolonged contest preparation for a proqualifying contest. During the 26-week preparation, the athlete undertook a calorically restrictive diet with 2 days of elevated carbohydrate intake per week, increased cardiovascular (CV) training, and attempted to maintain resistance-training load. The athlete was weighed twice a week and body composition was measured monthly by DXA. At baseline and every 2 weeks following CV structure and function was measured using a combination of ultrasound, applanation tonometry, and heart rate variability (HRV). Cardiorespiratory performance was measured by VO(2)peak at baseline, 13 weeks, and 26 weeks. Body weight (88.6 to 73.3 Kg, R(2) = .99) and percent body fat (17.5 to 7.4%) were reduced during preparation. CV measurements including blood pressure (128/61 to 113/54 mmHg), brachial pulse wave velocity (7.9 to 5.8m/s), and measures of wave reflection all improved. Indexed cardiac output was reduced (2.5 to 1.8L/m(2)) primarily due to a reduction in resting heart rate (71 to 44 bpm), and despite an increase in ejection faction (57.9 to 63.9%). Assessment of HRV found a shift in the ratio of low to high frequency (209.2 to 30.9%). Absolute VO2 was minimally reduced despite weight loss resulting in an increase in relative VO2 (41.9 to 47.7 ml/Kg). In general, this prolonged contest preparation technique helped the athlete to improve body composition and resulted in positive CV changes, suggesting that this method of contest preparation appears to be effective in natural male bodybuilders.

  4. Stem cell organization in Arabidopsis

    OpenAIRE

    Wendrich, J.R.

    2016-01-01

    Growth of plant tissues and organs depends on continuous production of new cells, by niches of stem cells. Stem cells typically divide to give rise to one differentiating daughter and one non-differentiating daughter. This constant process of self-renewal ensures that the niches of stem cells or meristems stay active throughout plant-life. Specification of stem cells occurs very early during development of the emrbyo and they are maintained during later stages. The Arabidopsis embryo is a hig...

  5. Servant Leadership through Distance Learning: A Case Study

    Science.gov (United States)

    Russell, Eric James

    2013-01-01

    This qualitative study explored the influence a distance learning servant leadership course had on the emergency service students' understanding of leadership. The research study utilized a case study design in order to tell the story of the lived experiences of the participants. The setting for the study was a state university in Utah, with…

  6. Development and evaluation of a Gal4-mediated LUC/GFP/GUS enhancer trap system in Arabidopsis

    Directory of Open Access Journals (Sweden)

    Schmuke Jon J

    2005-06-01

    Full Text Available Abstract Background Gal4 enhancer trap systems driving expression of LacZ and GFP reporters have been characterized and widely used in Drosophila. However, a Gal4 enhancer trap system in Arabidopsis has not been described in the primary literature. In Drosophila, the reporters possess a Gal4 upstream activation sequence (UAS as five repeats (5XUAS and lines that express Gal4 from tissue specific enhancers have also been used for the ectopic expression of any transgene (driven by a 5XUAS. While Gal4 transactivation has been demonstrated in Arabidopsis, wide use of a trap has not emerged in part because of the lack of detailed analysis, which is the purpose of the present study. Results A key feature of this study is the use of luciferase (LUC as the primary reporter and rsGFP-GUS as secondary reporters. Reporters driven by a 5XUAS are better suited in Arabidopsis than those containing a 1X or 2X UAS. A 5XUAS-LUC reporter is expressed at high levels in Arabidopsis lines transformed with Gal4 driven by the full, enhanced 35S promoter. In contrast, a minimum 35S (containing the TATA region upstream of Gal4 acts as an enhancer trap system. Luciferase expression in trap lines of the T1, T2, and T3 generations are generally stable but by the T4 generation approximately 25% of the lines are significantly silenced. This silencing is reversed by growing plants on media containing 5-aza-2'-deoxycytidine. Quantitative multiplex RT-PCR on the Gal4 and LUC mRNA indicate that this silencing can occur at the level of Gal4 or LUC transcription. Production of a 10,000 event library and observations on screening, along with the potential for a Gal4 driver system in other plant species are discussed. Conclusion The Gal4 trap system described here uses the 5XUAS-LUC and 5XUAS rsGFP-GUS as reporters and allows for in planta quantitative screening, including the rapid monitoring for silencing. We conclude that in about 75% of the cases silencing is at the level of

  7. Immigrants: A Study Case for N. Greece

    Directory of Open Access Journals (Sweden)

    Maria Vlachadi

    2014-05-01

    Full Text Available It is a fact that the phenomenon of immigration constitutes, during the last years, the view of a new social and economic reality for the societies of most western European countries. Greece has received for the first time, during the 1990s, thousands of economic immigrants who appear not only in the big city centers but also in small country towns. Immigrants probably constitute the most discussed issue in the Modern Greek society, in an economic conjuncture in which the economic crisis has functioned in a catalytic way for the diffusion of insecurity in the native population (Biblionet, 2012. The Greek state was not ready to accept such a large number of immigrants in so little time. It showed hesitance and could not keep a steady position as far as the promotion of a necessary institutional framework for their integration in the Greek society was concerned. This initial surprise has never been overcome. In Greece, as well as in the rest of the European South, the majority of the immigrants entering the country illegally have supplied the informal working market. Even when they become legal, the available working positions for them presuppose low specialization with low payments, hard work and limited opportunities of improvement of their social and occupational status. Although the immigration phenomenon is usually approached in a national level, the local level is considered the most suitable one to deal with the interaction of its economic, social, political and cultural dimensions. Recent studies have shown their positive contribution in the revival of Greek agriculture and Greek agricultural districts in general. Within the scale of the Greek community and the degree in which it constitutes a place of constant flow of human resources, it is inevitable the general presence of immigrants to raise issues of mutual infiltrations among different national populations within which there arise interaction issues and intercultural interdependence

  8. ML3: a novel regulator of herbivory-induced responses in Arabidopsis thaliana

    OpenAIRE

    Fridborg, I.; Johansson, A; Lagensjo, J.; Leelarasamee, N.; Floková, K. (Kristýna); Tarkowská, D. (Danuše); Meijer, J.; Bejai, S.

    2013-01-01

    ML (MD2-related lipid recognition) proteins are known to enhance innate immune responses in mammals. This study reports the analysis of the putative ML gene family in Arabidopsis thaliana and suggests a role for the ML3 gene in herbivory-associated responses in plants. Feeding by larvae of the Lepidopteran generalist herbivore Spodoptera littoralis and larvae of the specialist herbivore Plutella xylostella activated ML3 transcription in leaf tissues. ML3 loss-of-function Arabidopsis plants we...

  9. Potential role of Arabidopsis PHP as an accessory subunit of the PAF1 transcriptional cofactor.

    Science.gov (United States)

    Park, Sunchung; Ek-Ramos, Maria Julissa; Oh, Sookyung; van Nocker, Steven

    2011-08-01

    Paf1C is a transcriptional cofactor that has been implicated in various transcription-associated mechanisms spanning initiation, elongation and RNA processing, and is important for multiple aspects of development in Arabidopsis. Our recent studies suggest Arabidopsis Paf1C is crucial for proper regulation of genes within H3K27me3-enriched chromatin, and that a protein named PHP may act as an accessory subunit of Paf1C that promotes this function.

  10. Dynamic Nucleocytoplasmic Shuttling of an Arabidopsis SR Splicing Factor: Role of the RNA-Binding Domains

    OpenAIRE

    Rausin, Glwadys; Tillemans, Vinciane; Stankovic, Nancy; Hanikenne, Marc; Motte, Patrick

    2010-01-01

    Serine/arginine-rich (SR) proteins are essential nuclear-localized splicing factors. We have investigated the dynamic subcellular distribution of the Arabidopsis (Arabidopsis thaliana) RSZp22 protein, a homolog of the human 9G8 SR factor. Little is known about the determinants underlying the control of plant SR protein dynamics, and so far most studies relied on ectopic transient overexpression. Here, we provide a detailed analysis of the RSZp22 expression profile and describe its nucleocytop...

  11. Strategies for Energy Efficient Remodeling: SEER 2003 Case Study Report

    Energy Technology Data Exchange (ETDEWEB)

    None

    2004-11-01

    The goal of the Strategies for Energy Efficiency in Remodeling (SEER) project is to provide information, based on research and case studies, to remodelers and consumers about opportunities to increase home energy performance.

  12. PR Students, Teachers Welcome Corporate Case Study Packages.

    Science.gov (United States)

    Broom, Glen M.; Ferguson-De Thorne, Mary Ann

    1978-01-01

    Reports on an actual public relations problem that was used to introduce students to the practice of corporate public relations. Shows both positive and negative reaction to use of the case study in college classes. (RL)

  13. Whole House Mechanical Ventilation: A South Chicago Case Study

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-09-03

    This case study describes a neighborhood of efficient, healthy, sustainable, affordable homes in South Chicago, IL, that feature structural insulated panels (SIPs), condensing furnaces, sealed combustion water heaters, and efficient lights and appliances.

  14. Case Study of a Participatory Health Promotion Intervention in School

    DEFF Research Database (Denmark)

    Simovska, Venka

    2012-01-01

    study showed that, if given sufficient guidance, children can act as agents of health promoting changes. The main arena for pupils’ influence was the pupils’ council. Pupils were meaningfully involved in two actions, which targeted road safety around the school and a playground for a disadvantaged......In this article I discuss the findings from a case study focusing on processes involving pupils to bring about health promotion changes. The case study is related to a large EU intervention project aiming to promote health and wellbeing among children (4-16 years), ‘Shape Up: a school......-community approach to influencing determinants of healthy and balanced growing up’. Qualitative case study research was carried out in a school in the Netherlands. Data sources included project documents, interviews and observations. Thematic analysis was carried out combining the different data sources. The case...

  15. Modelling a case study in Astronomy with IMS Learning Design

    NARCIS (Netherlands)

    Burgos, Daniel; Tattersall, Colin

    2009-01-01

    Burgos, D., & Tattersall, C. (2008). Modelling a case study in Astronomy with IMS Learning Design [Electronic Version]. Journal of Interactive Media in Education, 2008 from http://jime.open.ac.uk/2008/19/.

  16. Industrial process heat case studies. [PROSYS/ECONMAT code

    Energy Technology Data Exchange (ETDEWEB)

    Hooker, D.W.; May, E.K.; West, R.E.

    1980-05-01

    Commercially available solar collectors have the potential to provide a large fraction of the energy consumed for industrial process heat (IPH). Detailed case studies of individual industrial plants are required in order to make an accurate assessment of the technical and economic feasibility of applications. This report documents the results of seven such case studies. The objectives of the case study program are to determine the near-term feasibility of solar IPH in selected industries, identify energy conservation measures, identify conditions of IPH systems that affect solar applications, test SERI's IPH analysis software (PROSYS/ECONOMAT), disseminate information to the industrial community, and provide inputs to the SERI research program. The detailed results from the case studies are presented. Although few near-term, economical solar applications were found, the conditions that would enhance the opportunities for solar IPH applications are identified.

  17. Analysis of Arabidopsis glutathione-transferases in yeast.

    Science.gov (United States)

    Krajewski, Matthias P; Kanawati, Basem; Fekete, Agnes; Kowalski, Natalie; Schmitt-Kopplin, Philippe; Grill, Erwin

    2013-07-01

    The genome of Arabidopsis thaliana encodes 54 functional glutathione transferases (GSTs), classified in seven clades. Although plant GSTs have been implicated in the detoxification of xenobiotics, such as herbicides, extensive redundancy within this large gene family impedes a functional analysis in planta. In this study, a GST-deficient yeast strain was established as a system for analyzing plant GSTs that allows screening for GST substrates and identifying substrate preferences within the plant GST family. To this end, five yeast genes encoding GSTs and GST-related proteins were simultaneously disrupted. The resulting yeast quintuple mutant showed a strongly reduced conjugation of the GST substrates 1-chloro-2,4-dinitrobenzene (CDNB) and 4-chloro-7-nitro-2,1,3-benzoxadiazole (NBD-Cl). Consistently, the quintuple mutant was hypersensitive to CDNB, and this phenotype was complemented by the inducible expression of Arabidopsis GSTs. The conjugating activity of the plant GSTs was assessed by in vitro enzymatic assays and via analysis of exposed yeast cells. The formation of glutathione adducts with dinitrobenzene was unequivocally verified by stable isotope labeling and subsequent accurate ultrahigh-resolution mass spectrometry (ICR-FTMS). Analysis of Arabidopsis GSTs encompassing six clades and 42 members demonstrated functional expression in yeast by using CDNB and NBD-Cl as model substrates. Subsequently, the established yeast system was explored for its potential to screen the Arabidopsis GST family for conjugation of the fungicide anilazine. Thirty Arabidopsis GSTs were identified that conferred increased levels of glutathionylated anilazine. Efficient anilazine conjugation was observed in the presence of the phi, tau, and theta clade GSTs including AtGSTF2, AtGSTF4, AtGSTF6, AtGSTF8, AtGSTF10, and AtGSTT2, none of which had previously been known to contribute to fungicide detoxification. ICR-FTMS analysis of yeast extracts allowed the simultaneous detection and

  18. Integrated dementia care in The Netherlands: a multiple case study of case management programmes.

    Science.gov (United States)

    Minkman, Mirella M N; Ligthart, Suzanne A; Huijsman, Robbert

    2009-09-01

    The number of dementia patients is growing, and they require a variety of services, making integrated care essential for the ability to continue living in the community. Many healthcare systems in developed countries are exploring new approaches for delivering health and social care. The purpose of this study was to describe and analyse a new approach in extensive case management programmes concerned with long-term dementia care in The Netherlands. The focus is on the characteristics, and success and failure factors of these programmes.A multiple case study was conducted in eight regional dementia care provider networks in The Netherlands. Based on a literature study, a questionnaire was developed for the responsible managers and case managers of the eight case management programmes. During 16 semistructured face-to-face interviews with both respondent groups, a deeper insight into the dementia care programmes was provided. Project documentation for all the cases was studied. The eight programmes were developed independently to improve the quality and continuity of long-term dementia care. The programmes show overlap in terms of their vision, tasks of case managers, case management process and the participating partners in the local dementia care networks. Differences concern the targeted dementia patient groups as well as the background of the case managers and their position in the local dementia care provider network. Factors for success concern the expert knowledge of case managers, investment in a strong provider network and coherent conditions for effective inter-organizational cooperation to deliver integrated care. When explored, caregiver and patient satisfaction was high. Further research into the effects on client outcomes, service use and costs is recommended in order to further analyse the impact of this approach in long-term care. To facilitate implementation, with a focus on joint responsibilities of the involved care providers, policy

  19. Cautionary tales: ethics and case studies in science.

    Science.gov (United States)

    Herreid, Clyde Freeman

    2014-12-01

    Ethical concerns are normally avoided in science classrooms in spite of the fact that many of our discoveries impinge directly on personal and societal values. We should not leave the ethical problems for another day, but deal with them using realistic case studies that challenge students at their ethical core. In this article we illustrate how case studies can be used to teach STEM students principles of ethics. PMID:25574280

  20. Clinical waste incinerators in Cameroon--a case study

    DEFF Research Database (Denmark)

    Mochungong, Peter Ikome Kuwoh; Gulis, Gabriel; Sodemann, Morten

    2012-01-01

    Incinerators are widely used to treat clinical waste in Cameroon's Northwest Region. These incinerators cause public apprehension owing to purported risks to operators, communities and the environment. This article aims to summarize findings from an April 2008 case study.......Incinerators are widely used to treat clinical waste in Cameroon's Northwest Region. These incinerators cause public apprehension owing to purported risks to operators, communities and the environment. This article aims to summarize findings from an April 2008 case study....

  1. Case Studies of Heat Integration of Evaporation Systems

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    In this paper, through two case studies, evaporation systems are considered in the context of overall process, and then are optimized to obtain energy-saving effect. The possible evaporation schemes are given when integrated with the background process and how to optimize the evaporator is shown. From the case studies, it can be seen that sometimes incomplete integration and heat pump evaporation are better than complete integration so should be considered as candidate retrofit schemes.

  2. Case Study Method in Business Education in the USA

    OpenAIRE

    Velushchak Maryna

    2014-01-01

    Business Education is dynamic in nature and needs diverse information to deal with different business problems. To understand the peculiar situations and to manage them effectively, case studies are widely used. Researchers in education have already demonstrated that students' active participation in the educational process increases their learning outcomes. Methods of small group activities, case studies and cooperative student projects give the opportunity to participate actively in the lea...

  3. Transformational change in healthcare: an examination of four case studies.

    Science.gov (United States)

    Charlesworth, Kate; Jamieson, Maggie; Davey, Rachel; Butler, Colin D

    2016-04-01

    Objectives Healthcare leaders around the world are calling for radical, transformational change of our health and care systems. This will be a difficult and complex task. In this article, we examine case studies in which transformational change has been achieved, and seek to learn from these experiences. Methods We used the case study method to investigate examples of transformational change in healthcare. The case studies were identified from preliminary doctoral research into the transition towards future sustainable health and social care systems. Evidence was collected from multiple sources, key features of each case study were displayed in a matrix and thematic analysis was conducted. The results are presented in narrative form. Results Four case studies were selected: two from the US, one from Australia and one from the UK. The notable features are discussed for each case study. There were many common factors: a well communicated vision, innovative redesign, extensive consultation and engagement with staff and patients, performance management, automated information management and high-quality leadership. Conclusions Although there were some notable differences between the case studies, overall the characteristics of success were similar and collectively provide a blueprint for transformational change in healthcare. What is known about the topic? Healthcare leaders around the world are calling for radical redesign of our systems in order to meet the challenges of modern society. What does this paper add? There are some remarkable examples of transformational change in healthcare. The key factors in success are similar across the case studies. What are the implications for practitioners? Collectively, these key factors can guide future attempts at transformational change in healthcare. PMID:26188916

  4. Analysing interview data of case study in educational research

    Institute of Scientific and Technical Information of China (English)

    赵艳敏

    2014-01-01

    interviews are an essential source in collecting case study data, because most of case studies are about human affairs. Yin (2003) reported that human affairs should be interpreted through the eyes and body languages of interviewees, and they can provide very important insights into a situation. However, it is also necessary to pay attention to the common biases caused by interview, such as poor recall, inaccurate articulation and time-consuming.

  5. Hospital visitors as controls in case-control studies

    OpenAIRE

    Gulnar Azevedo S Mendonça; José Eluf-Neto

    2001-01-01

    OBJECTIVE: Selecting controls is one of the most difficult tasks in the design of case-control studies. Hospital controls may be inadequate and random controls drawn from the base population may be unavailable. The aim was to assess the use of hospital visitors as controls in a case-control study on the association of organochlorinated compounds and other risk factors for breast cancer conducted in the main hospital of the "Instituto Nacional de Câncer" -- INCA (National Cancer Institute) in ...

  6. CSSI12 Workshop Proceedings - Case Studies in Service Innovation

    OpenAIRE

    Theodoulidis, Babis

    2012-01-01

    The purpose of Case Studies in Service Innovation is to give the reader insights into how innovation occurs in practice and to stimulate understanding of the underlying theories, models, and tools that contribute to innovation, how it works in practice and how its impact is evaluated. Case Studies in Service Innovation brings together contributions from researchers and practitioners in a celebration of achievements in innovation in practice but also at the same time to look forward by examini...

  7. Using the case-study method in teaching college physics

    OpenAIRE

    Burko, Lior M.

    2016-01-01

    The case-study teaching method has a long history (starting at least with Socrates), and wide current use in business schools, medical schools, law schools, and a variety of other disciplines. However, relatively little use is made of it in the physical sciences, specifically in physics or astronomy. The case-study method should be considered by physics faculty as part of the effort to transition the teaching of college physics from the traditional frontal-lecture format to other formats that...

  8. Security risk analysis in retail store, Case study: Company X

    OpenAIRE

    Nugrahany, Raihana

    2015-01-01

    This thesis was conducted to protect the valuable assets of the case study company. By using the risk analysis, it will improve their business resilience by being well organized to prevent the occurrence of the threats and taking appropriate measure as response to it and by applying corporate security it can help to manage the safety of business function and assets of the case company. The purpose of this study is to identify various type of external and internal risk in the case company...

  9. DEVELOPMENT OF CROSS-BORDER AREAS. STUDY CASES REVIEW

    Directory of Open Access Journals (Sweden)

    Marcela\tȘLUSARCIUC

    2015-06-01

    Full Text Available The paper aims to review study cases found in the scientific literature concerning the development of cross- border areas in European Union and its neighbourhood. The introductory part of the paper is drawing few considerations about the cross-border areas. Further we identified in the specific literature relevant study cases that provide lessons learned, tools and models that can contribute to the development of the cross-border areas. The last part of the paper is focusing on an inquiry about how this lessons, learned, tools and models may be adapted in case of cross-border areas along the Romanian border with the EU Eastern Neighbourhood.

  10. Comparative Study on Effects of Low Energy N+ Implantation and γ-ray Radiation on Heredity and Development of Arabidopsis Thaliana

    Institute of Scientific and Technical Information of China (English)

    Zhang Genfa; Li Ke; Shi Xiaoming; Nie Yanli; Zhang Jun; Zhou Hongyu; Lu Ting

    2005-01-01

    In order to compare the contemporary and genetic variation effect on Arabidopsis thaliana treated with N+ implantation and γ-ray radiation, the authors did some statistical comparison on the germinating rate and the development period, and analyzed the content of soluble proteins, the activity of some enzymes, isoenzymes profile, and along with the variation in genome DNA of two generations by RAPD. With N+ implantation there was an analogical "saddle model" relationship between doses and the plant development, soluble proteins, the activity of some enzymes and isoenzymes profile. A certain connection might exist between the similar dose-effect relations among enzymes activity, isoenzymes profile and content of soluble proteins.Maybe, there also exists a certain connection between the mutants of development period and that of DNA variations, between the hereditability of the effect of N+ implantation on the isoenzymes,the activities of enzymes and the hereditability of DNA variations. So it is presumed that the implanted ions, maybe, have participated in metabolism process of organism including that of genome DNA, to consequently affect vital process, such as the changes of gene structure, gene expression manner and gene repair mechanism, and finally result in mutation on phenotype and molecular level. Furthermore, the results definitely showed that mutagenic mechanism induced by N+ implantation is very complicated and is much different from that induced by traditional γ-ray radiation.

  11. STUDY OF MATERNAL AND PERINATAL OUTCOME IN REFERRED OBSTETRICS CASES

    Directory of Open Access Journals (Sweden)

    Umesh

    2015-03-01

    Full Text Available OBJECTIVE: To review the referred obstetric cases for reason of referral and to study the maternal and perinatal outcome. DESIGN: Prospective Observational study . STUDY POPULATION: 380 cases referred from periphery to tertiary care institute in one year duration. METHODS: INCLUSION C RITERIA : All referred ANC cases to our tertiary care institute >20 weeks gestation. The total number of deliveries during this period were 11106. The total number of referred cases in above study period was 1980. Out of these 1520 met the inclusion criteria & according to the sample size calculated 380 cases were selected for the study. Selection of cases were done by systematic sampling technique. RESULTS: The proportion of referral cases to the tertiary care institute is 17.83%. Majority (42.37% of referred cases were from district level hospitals showing lacunae in the emergency obstetric care given at the district level hospitals. In present study, there was unavailability of ambulance in 65.26% of cases for transport. Most (92.89% of the patients were not accompanied by any medical assistance during transport. Major complication during immediate postpartum period was postpartum hemorrhage (19.99%. In our study, 31.84% of the patients required blood/blood products transfusion. There were 3(0.79% maternal mortalities in present study & behind these there were total 70(18.42% near miss cases which provide valuable information on the quality of antenatal care at the periphery. 54.87% of all neonates had low birth weight in this study. In present study, 45.90% babies were p reterm. Total NICU admission rate was 14.36%. Neonatal mortality documented in present study was 5.38%. CONCLUSION: The present study has shown that improper antenatal & intranatal care at the periphery level is responsible for poor maternal & perinatal outcome. Rural women have very poor access to MCH services. There is lack of Transportation facilities for referral patients & they have to

  12. Using the Case Study Method in Teaching College Physics

    Science.gov (United States)

    Burko, Lior M.

    2016-10-01

    The case study teaching method has a long history (starting at least with Socrates) and wide current use in business schools, medical schools, law schools, and a variety of other disciplines. However, relatively little use is made of it in the physical sciences, specifically in physics or astronomy. The case study method should be considered by physics faculty as part of the effort to transition the teaching of college physics from the traditional frontal-lecture format to other formats that enhance active student participation. In this paper we endeavor to interest physics instructors in the case study method, and hope that it would also serve as a call for more instructors to produce cases that they use in their own classes and that can also be adopted by other instructors.

  13. Using the case-study method in teaching college physics

    CERN Document Server

    Burko, Lior M

    2016-01-01

    The case-study teaching method has a long history (starting at least with Socrates), and wide current use in business schools, medical schools, law schools, and a variety of other disciplines. However, relatively little use is made of it in the physical sciences, specifically in physics or astronomy. The case-study method should be considered by physics faculty as part of the effort to transition the teaching of college physics from the traditional frontal-lecture format to other formats that enhance active student participation. In this paper we endeavor to interest physics instructors in the case-study method, and hope that it would also serve as a call for more instructors to produce cases that they use in their own classes and that can also be adopted by other instructors.

  14. Evaluation of School Uniform Policy in Turkey: A Case Study

    Science.gov (United States)

    Cinoglu, Mustafa

    2014-01-01

    The purpose of this study is to evaluate the results of current school uniform policies according to views of stakeholders. Descriptive case study method was used for this study to understand the concerns of the stakeholders about school uniforms. Data was collected through interviews with stakeholders and also reviewing the documents in TOKI…

  15. Postchemotherapy Histopathological Evaluation of Ovarian Carcinoma: A 40-Case Study

    OpenAIRE

    Kanwardeep Kaur Tiwana; Sarita Nibhoria; Manmeet Kaur; Tanvi Monga; Ratika Gupta

    2015-01-01

    Ovarian carcinomas are conventionally treated with primary debulking surgery followed by chemotherapy. Nowadays neoadjuvant chemotherapy followed by surgery is an upcoming treatment modality for ovarian carcinoma. This study highlights the histopathological changes observed after neoadjuvant chemotherapy. Present study is a 40-case study stressing five histological parameters: residual tumour, fibrosis, necrosis, inflammation, and psammoma bodies. All these parameters carry prognostic signifi...

  16. School Administration Leadership Style and Academic Achievement: A Case Study

    Science.gov (United States)

    Brvenik-Estrella, Marianna

    2013-01-01

    The purpose of this case study was to gather current teacher and administrator perceptions on leadership in a school environment. The study sought to identify patterns of leadership style as elements in building a school climate that focused on performance and intrinsic rewards. The study also sought to establish an understanding of how leadership…

  17. Arabidopsis CDS blastp result: AK240730 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK240730 J043030K09 At2g32440.1 68415.m03963 ent-kaurenoic acid hydroxylase, putati...ve / cytochrome P450, putative identical to ent-kaurenoic acid hydroxylase / cytochrome P450 CYP88A (GI:1302...1856) [Arabidopsis thaliana]; similar to ent-kaurenoic acid hydroxylase [Arabidopsis thaliana] GI:13021853 2e-11 ...

  18. Arabidopsis CDS blastp result: AK288052 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK288052 J075151I09 At2g32440.1 68415.m03963 ent-kaurenoic acid hydroxylase, putati...ve / cytochrome P450, putative identical to ent-kaurenoic acid hydroxylase / cytochrome P450 CYP88A (GI:1302...1856) [Arabidopsis thaliana]; similar to ent-kaurenoic acid hydroxylase [Arabidopsis thaliana] GI:13021853 6e-14 ...

  19. Arabidopsis CDS blastp result: AK240911 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK240911 J065037E05 At2g32440.1 68415.m03963 ent-kaurenoic acid hydroxylase, putati...ve / cytochrome P450, putative identical to ent-kaurenoic acid hydroxylase / cytochrome P450 CYP88A (GI:1302...1856) [Arabidopsis thaliana]; similar to ent-kaurenoic acid hydroxylase [Arabidopsis thaliana] GI:13021853 4e-22 ...

  20. Arabidopsis CDS blastp result: AK241119 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK241119 J065094C22 At2g32440.1 68415.m03963 ent-kaurenoic acid hydroxylase, putati...ve / cytochrome P450, putative identical to ent-kaurenoic acid hydroxylase / cytochrome P450 CYP88A (GI:1302...1856) [Arabidopsis thaliana]; similar to ent-kaurenoic acid hydroxylase [Arabidopsis thaliana] GI:13021853 2e-13 ...

  1. Arabidopsis CDS blastp result: AK243149 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK243149 J100032I21 At2g32440.1 68415.m03963 ent-kaurenoic acid hydroxylase, putati...ve / cytochrome P450, putative identical to ent-kaurenoic acid hydroxylase / cytochrome P450 CYP88A (GI:1302...1856) [Arabidopsis thaliana]; similar to ent-kaurenoic acid hydroxylase [Arabidopsis thaliana] GI:13021853 7e-12 ...

  2. Arabidopsis CDS blastp result: AK241581 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK241581 J065181K09 At2g32440.1 68415.m03963 ent-kaurenoic acid hydroxylase, putati...ve / cytochrome P450, putative identical to ent-kaurenoic acid hydroxylase / cytochrome P450 CYP88A (GI:1302...1856) [Arabidopsis thaliana]; similar to ent-kaurenoic acid hydroxylase [Arabidopsis thaliana] GI:13021853 4e-15 ...

  3. Arabidopsis CDS blastp result: AK287479 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK287479 J043023O14 At2g32440.1 68415.m03963 ent-kaurenoic acid hydroxylase, putati...ve / cytochrome P450, putative identical to ent-kaurenoic acid hydroxylase / cytochrome P450 CYP88A (GI:1302...1856) [Arabidopsis thaliana]; similar to ent-kaurenoic acid hydroxylase [Arabidopsis thaliana] GI:13021853 1e-17 ...

  4. Using "Arabidopsis" Genetic Sequences to Teach Bioinformatics

    Science.gov (United States)

    Zhang, Xiaorong

    2009-01-01

    This article describes a new approach to teaching bioinformatics using "Arabidopsis" genetic sequences. Several open-ended and inquiry-based laboratory exercises have been designed to help students grasp key concepts and gain practical skills in bioinformatics, using "Arabidopsis" leucine-rich repeat receptor-like kinase (LRR RLK) genetic…

  5. Genetic Analyses of Meiotic Recombination in Arabidopsis

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Meiosis is essential for sexual reproduction and recombination is a critical step required for normal meiosis. Understanding the underlying molecular mechanisms that regulate recombination ie important for medical, agricultural and ecological reasons. Readily available molecular and cytological tools make Arabidopsis an excellent system to study meiosis. Here we review recent developments in molecular genetic analyses on meiotic recombination. These Include studies on plant homologs of yeast and animal genes, as well as novel genes that were first identified in plants. The characterizations of these genes have demonstrated essential functions from the initiation of recombination by double-strand breaks to repair of such breaks, from the formation of double-Holliday junctions to possible resolution of these junctions, both of which are critical for crossover formation. The recent advances have ushered a new era in plant meiosis, in which the combination of genetics, genomics, and molecular cytology can uncover important gene functions.

  6. An International Bioinformatics Infrastructure to Underpin the Arabidopsis Community

    Science.gov (United States)

    The future bioinformatics needs of the Arabidopsis community as well as those of other scientific communities that depend on Arabidopsis resources were discussed at a pair of recent meetings held by the Multinational Arabidopsis Steering Committee (MASC) and the North American Arabidopsis Steering C...

  7. Casing Pipe Damage Detection with Optical Fiber Sensors: A Case Study in Oil Well Constructions

    OpenAIRE

    Genda Chen; Jun He; Jianping He; Minghua Huang; Zhi Zhou

    2010-01-01

    Casing pipes in oil well constructions may suddenly buckle inward as their inside and outside hydrostatic pressure difference increases. For the safety of construction workers and the steady development of oil industries, it is critically important to measure the stress state of a casing pipe. This study develops a rugged, real-time monitoring, and warning system that combines the distributed Brillouin Scattering Time Domain Reflectometry (BOTDR) and the discrete fiber Bragg grating (FBG) mea...

  8. Identification of Polyadenylation Sites within Arabidopsis Thaliana

    KAUST Repository

    Kalkatawi, Manal

    2011-09-01

    Machine Learning (ML) is a field of artificial intelligence focused on the design and implementation of algorithms that enable creation of models for clustering, classification, prediction, ranking and similar inference tasks based on information contained in data. Many ML algorithms have been successfully utilized in a variety of applications. The problem addressed in this thesis is from the field of bioinformatics and deals with the recognition of polyadenylation (poly(A)) sites in the genomic sequence of the plant Arabidopsis thaliana. During the RNA processing, a tail consisting of a number of consecutive adenine (A) nucleotides is added to the terminal nucleotide of the 3’- untranslated region (3’UTR) of the primary RNA. The process in which these A nucleotides are added is called polyadenylation. The location in the genomic DNA sequence that corresponds to the start of terminal A nucleotides (i.e. to the end of 3’UTR) is known as a poly(A) site. Recognition of the poly(A) sites in DNA sequence is important for better gene annotation and understanding of gene regulation. In this study, we built an artificial neural network (ANN) for the recognition of poly(A) sites in the Arabidopsis thaliana genome. Our study demonstrates that this model achieves improved accuracy compared to the existing predictive models for this purpose. The key factor contributing to the enhanced predictive performance of our ANN model is a distinguishing set of features used in creation of the model. These features include a number of physico-chemical characteristics of relevance, such as dinucleotide thermodynamic characteristics, electron-ion interaction potential, etc., but also many of the statistical properties of the DNA sequences from the region surrounding poly(A) site, such as nucleotide and polynucleotide properties, common motifs, etc. Our ANN model was compared in performance with several other ML models, as well as with the PAC tool that is specifically developed for

  9. A retrospective study of nine cases of Acanthamoeba keratitis

    Directory of Open Access Journals (Sweden)

    Tetsuya Mutoh

    2010-10-01

    Full Text Available Tetsuya Mutoh, Isao Ishikawa, Yukihiro Matsumoto, Makoto ChikudaDokkyo Medical University Koshigaya Hospital, Saitama, JapanPurpose: To evaluate the clinical features of Acanthamoeba keratitis in nine patients diagnosed at Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.Methods: In nine eyes of nine patients, Acanthamoeba keratitis was diagnosed by direct light microscopy of corneal scrapings stained by the Parker ink-potassium hydroxide method between September 2006 and September 2009. Their clinical features and course were studied retrospectively. Antifungal eye drops, systemic antifungal therapy, and surgical debridement of the corneal lesions were performed in all patients.Results: At presentation, the clinical stage was initial in six cases, transient in one case, and complete in two cases. The patients were all contact lens wearers who had washed their lens storage cases with tap water. After treatment, final visual acuity was improved in six cases, unchanged in one case, and worse in two cases. The patient with the worst final vision (hand motion had rheumatoid arthritis and was taking oral prednisolone, which led to corneal perforation and prevented adequate debridement from being done.Conclusion: Acanthamoeba keratitis is closely related to wearing contact lenses and washing the lens storage case with tap water. Although final visual acuity improved after treatment in most patients, insufficient surgical debridement resulted in a poor visual prognosis.Keywords: surgical debridement, Acanthamoeba keratitis, contact lens wearers

  10. Assessment of global phase uncertainty in case-control studies

    Directory of Open Access Journals (Sweden)

    van Houwelingen Hans C

    2009-09-01

    Full Text Available Abstract Background In haplotype-based candidate gene studies a problem is that the genotype data are unphased, which results in haplotype ambiguity. The measure 1 quantifies haplotype predictability from genotype data. It is computed for each individual haplotype, and for a measure of global relative efficiency a minimum value is suggested. Alternatively, we developed methods directly based on the information content of haplotype frequency estimates to obtain global relative efficiency measures: and based on A- and D-optimality, respectively. All three methods are designed for single populations; they can be applied in cases only, controls only or the whole data. Therefore they are not necessarily optimal for haplotype testing in case-control studies. Results A new global relative efficiency measure was derived to maximize power of a simple test statistic that compares haplotype frequencies in cases and controls. Application to real data showed that our proposed method gave a clear and summarizing measure for the case-control study conducted. Additionally this measure might be used for selection of individuals, who have the highest potential for improving power by resolving phase ambiguity. Conclusion Instead of using relative efficiency measure for cases only, controls only or their combined data, we link uncertainty measure to case-control studies directly. Hence, our global efficiency measure might be useful to assess whether data are informative or have enough power for estimation of a specific haplotype risk.

  11. Case Study Method in Business Education in the USA

    Directory of Open Access Journals (Sweden)

    Velushchak Maryna

    2014-12-01

    Full Text Available Business Education is dynamic in nature and needs diverse information to deal with different business problems. To understand the peculiar situations and to manage them effectively, case studies are widely used. Researchers in education have already demonstrated that students' active participation in the educational process increases their learning outcomes. Methods of small group activities, case studies and cooperative student projects give the opportunity to participate actively in the learning process by talking, reading, writing and reflecting. Case-based learning is an essential part of business education as it enables students to discover and develop their unique framework for dealing with business problems. The important peculiarity of the business case study is that it introduces a slice of realism into the learning experience. The case study method helps the students in developing wisdom and gives lot of scope for knowledge application. Nowadays, business education should be much more practically oriented and has to consider the main features of a modern competitive global economy. Lectures and discussions are not any more the most effective teaching methods. As research results show, the case method is the most effective teaching technique of future career preparations and practical application skills in today's business environment as it enables students examining different business situations in various cultural and economic perspectives, opening up their minds by solving the problems of the real business situations.

  12. An autopsy study of 74 cases of cut throat injuries

    Directory of Open Access Journals (Sweden)

    Dinesh Rao

    2015-12-01

    Full Text Available The present prospective autopsy study was carried out during the period July 2009 to May 2012 in Kingston, Jamaica. A total of 74 cases of cut throat injury were studied. All the cut throat injuries irrespective of those directly or indirectly contributing to the death were studied. Males dominated the list of victims, contributing to 71.62% (n = 53. Majority of those were in the age group 21–30 (n = 25 and 31–40 (n = 26 which contributed to 33.78% and 35.13% respectively. Majority of the cases were homicides contributing to 97.29% (n = 72 of cases, only 2.7% were suicides and accidental cut throat were never reported. Males dominated the homicides category contributing to 72.22% (n = 52 of the cases. Gang and relationship crisis (homosexual and heterosexual were the major motivating factors, each contributing to 39.19% (n = 29 and 32.43% (n = 24 of the cases, respectively. The disease suffered by individuals were the least motivating factors contributing to 1.35% of cases (n = 01. The most common cause of death was exsanguinations in 49.95% (n = 34 of cases followed closely by asphyxia due to aspiration of blood i.e. 36.49% (n = 27 of cases and air embolism was the least cause of death, contributing to 4.05% (n = 03 of cases. Cut throat injury was associated with other injuries like gunshot wound, chop wounds and stab wounds in 13.52% of (n = 10 autopsies. Chop injuries contributed to maximum number of other injuries in homicides (n = 46. The most preferred place for the crime was an open field or farm (n = 26. Majority of the cut throat wounds were situated in zone II level contributing to 66.21% (n = 49 of cases. Majority of the wounds were directed from left to right in 75.68% (n = 56 of cases and the cervical vertebra was affected in 8.11% (n = 06 of cases. Major weapon of choice was machete contributing to 83.78% (n = 62 of injuries. The low income group was the most affected group contributing to 91

  13. STROKE IN YOUNG ADULTS: A RETROSPECTIVE STUDY OF 68 CASES

    Directory of Open Access Journals (Sweden)

    M. H. Harirchian

    2006-06-01

    Full Text Available Numerous etiologies are responsible for cases of stroke in young adults. This study reviews the causes of two types of stroke (ischemic and intracerebral hemorrhage in young adults aged 15 to 40years, admitted to our center (a tertiary care center from 1997 to 2002. The purpose of this study is to determine the relative frequency of causes of stroke in young adults and compare this with published data in the literature. Using the codes 46.0 to 46.8 of the International Classification of Diseases- 10th Edition (ICD-10, cases were identified from the records of the stroke patients admitted in Imam Khomeini Hospital and the data were collected from their files using a comprehensive questionnaire. Forty-two cases of ischemic stroke (62% and 26 cases of intracerebral hemorrhage (38% were identified. The leading cause of ischemic stroke was cardioembolism (38.1%, followed by atherosclerosis in 5 cases (11.9%. Among cardiac causes infarction was attributable to consequences of rheumatic heart disease in 8 cases. In 3 cases a cessation or decrease in dose of warfarin was followed directly by an ischemic stroke. The most leading cause of intracerebral hemorrhage was hypertension (30.8%. Other causes were anticoagulant therapy, intratumoral hemorrhage, aplastic anemia, leukemia, arteriovenous malformations, and chronic active hepatitis. In conclusion, cardioembolism and hypertension were the most leading causes of ischemic and hemorrhagic stroke in young adults admitted in our hospital.

  14. Conducting a pilot study: case study of a novice researcher.

    Science.gov (United States)

    Doody, Owen; Doody, Catriona M

    Pilot studies play a vital role in health research, but are often misused, mistreated and misrepresented. A well-conducted pilot study with clear aims and objectives within a formal framework ensures methodological rigour, can lead to higher-quality research and scientifically valid work that is publishable and can benefit patients and health service delivery. A pilot study contributes valuable information to assist researchers in the conduct of their study. Conducting a pilot study provides the researcher with the opportunity to develop and enhance the skills necessary before commencing the larger study. By conducting a pilot the researcher obtains preliminary data, can evaluate their data-analysis method and clarify the financial and human resources required. This article presents an overview of pilot studies, why they are conducted, what to consider when reporting pilot studies and the authors' experience of conducting a pilot study. To conduct a successful study, researchers need to develop their skills, choose the right methods and carefully plan for all aspects of the process. PMID:26618678

  15. A Specification—Based Case Study from Test Class Framework

    Institute of Scientific and Technical Information of China (English)

    LIULing; MIAOHuai-kou

    2001-01-01

    Testing is a standard method for verification of software performance.Producing efficinet and appropriate test case is an important aspect in testing.Specification-based testing presents a method to derive test data from software specification.Because of the precision and concision of specification.the test data derived from specification can test the software efficiently and entirely.This paper demonstrates a test class framework(TCF) on a file reading case study,specifiec using Z notation,This class framework defines test case sets,providing structure to the testing process.Flexbility is preserved so that many testing strategies can be used.

  16. Using parental phenotypes in case-parent studies

    OpenAIRE

    Min eShi; David eUmbach; Clarice eWeinberg

    2015-01-01

    In studies of case-parent triads, information is often collected about history of the condition in the parents, but typically parental phenotypes are ignored. Including that information in analyses may increase power to detect genetic association for autosomal variants. Our proposed approach uses parental phenotypes to assess association independently of the usual case-parent-based association test, enabling cross-generational internal replication for findings based on offspring and their par...

  17. Spatial Analysis of Childhood Cancer: A Case/Control Study

    OpenAIRE

    Rebeca Ramis; Diana Gómez-Barroso; Ibon Tamayo; Javier García-Pérez; Antonio Morales; Elena Pardo Romaguera; Gonzalo López-Abente

    2015-01-01

    Background Childhood cancer was the leading cause of death among children aged 1-14 years for 2012 in Spain. Leukemia has the highest incidence, followed by tumors of the central nervous system (CNS) and lymphomas (Hodgkin lymphoma, HL, and Non-Hodgkin’s lymphoma, NHL). Spatial distribution of childhood cancer cases has been under concern with the aim of identifying potential risk factors. Objective The two objectives are to study overall spatial clustering and cluster detection of cases of t...

  18. Low to high performance recycled cementitious materials: case studies

    OpenAIRE

    Etxeberria Larrañaga, Miren

    2015-01-01

    In this work, four real case studies using concrete produced with recycled aggregates are described. The four real cases carried out in Barcelona are: 1) Pavement filling with control low strength material (CLSM) employing fine recycled aggregates, 2) pervious recycled aggregate concrete employing coarse mixed recycled aggregates in the works undertaken at Cervantes park; 3) Concrete blocks produced employing recycled and slag aggregates as well as sea water for a new breakwater dyke and 4) R...

  19. Eccrine Angiomatous Hamartoma: A Retrospective Study of 15 Cases

    OpenAIRE

    Yi-Ting Lin; Chien-Ming Chen; Chih-Hsun Yang; Yea-Huey Chuang

    2012-01-01

    Background: Eccrine angiomatous hamartoma (EAH) comprises a rare nevoid proliferation of normal eccrine glands and small blood vessels and occasionally otherelements in the middle and deep dermis with variable clinical manifestations.Case series have rarely been published except for case reports and literaturereviews. The aims of this article were to investigate the clinical and pathologic features of patients with EAH in Taiwan and to compare our resultswith the results of previous studies.M...

  20. Epidemio-allergological study in 155 cases of footwear dermatitis

    OpenAIRE

    Chowdhuri Sanjib; Ghosh Sanjay

    2007-01-01

    Background : Footwear dermatitis represents a distinct and common group among all types of contact dermatitis cases seen in India. This ailment, however, often remains undiagnosed, misdiagnosed or empirically diagnosed without pinpointing the contributory allergens. Aims : This study was undertaken to detect the epidemio-allergological pattern of footwear dermatitis in India. Methods : A total number of 155 cases with footwear dermatitis were evaluated from July 2005 to June 2006, by detail...