WorldWideScience

Sample records for aquaretic system evidence

  1. Method for the detection of aquaretic compounds

    DEFF Research Database (Denmark)

    2003-01-01

    Disclosed is a method for detecting an aquaretic compound. In one embodiment, the method includes administering to a mammal a candidate compound that modulates a nociceptin receptor. Biological material is isolated from the mammal and expression of aquaporin-2 is measured. Modulation of the aquap...... of the aquaporin-2 is taken to be indicative of a candidate compound having aquaretic activity. The invention has a wide spectrum of uses including helping to identify new diuretics that spare unwanted loss of sodium and potassium ions....

  2. Effects of terlipressin on the aquaretic system - evidence of antidiuretic effects

    DEFF Research Database (Denmark)

    Krag, Alexander; Bendtsen, Flemming; Pedersen, Erling Bjerregaard

    2008-01-01

    with refractory ascites were included. The subjects were studied during a 400 mL/hour oral water load before and after infusion of 2 mg terlipressin (18 patients) or placebo infusion (4 patients). Effects on the V2 receptors were assessed by evaluating aquaporin-2 (AQP-2) excretion, free water clearance (CH2O......), urine osmolality (U-osm) and fractional distal water excretion (DFeH2O). Results: After terlipressin the excretion of AQP-2 increased by 89% (144 ng/(mmol creatinine), 95% confidence interval (CI) 73-214 ng/(mmol creatinine), p=0.001). CH2O decreased 1.05 mL/min (from 0.17 to -0.89 mL/min, p=0.......001) and DFeH2O decreased 37% (19 vs. 12; 95% CI 2-11, p=0.01). U-osm increased by 27% (93 mosm/kg, 95% CI 23-164, p=0.02). Plasma sodium decreased 1.1 mmol/L (pwater excretion after terlipressin despite water loading...

  3. From Water to Aquaretics: a Legendary Route

    Directory of Open Access Journals (Sweden)

    Valentina Donato

    2014-05-01

    Full Text Available Man is water. When life appeared on earth, the primordial cell had a simple structure and could immediately ascertain from the surrounding aquatic environment the substances for nutrition and oxygen, without any need for structural complexity. As part of evolution, during the transition from aquatic to terrestrial life, vertebrates had to fight against dehydration as well as fish in the sea. In this complex mechanism of osmoregulation, the structure and function of some osmoregulatory hormones have been maintained during the evolution of species, from fish to man. Within the homeostatic mechanism, the renin-angiotensin-aldosterone system (RAAS is crucial in the regulation of renal reasorption of water and sodium. It is also involved in the regulation of renal plasma flux, blood volume and blood pressure. Vasopressin plays a hormonal function in the mechanisms of water homeostasis acting through Aquaporins (AQP, channel-proteins that allow bi-directional water transport across cell membranes.

  4. Triple Diuretics and Aquaretic Strategy for Acute Decompensated Heart Failure due to Volume Overload

    Directory of Open Access Journals (Sweden)

    Rita Jermyn

    2013-01-01

    Full Text Available Diuretics, including furosemide, metolazone, and spironolactone, have historically been the mainstay of therapy for acute decompensated heart failure patients. The addition of an aquaretic-like vasopressin antagonist may enhance diuresis further. However, clinical experience with this quadruple combination is lacking in the acute setting. We present two hospitalized patients with acute decompensated heart failure due to massive fluid overload treated with a combination strategy of triple diuretics in conjunction with the aquaretic tolvaptan. The first patient lost 72.1 lbs. (32.7 kg with an average urine output of 3.5 to 7.5 L/day over eight days on combined therapy with furosemide, metolazone, spironolactone, and tolvaptan. The second patient similarly achieved a weight loss of 28.2 lbs. (12.8 kg over 4 days on the same treatment. Both patients maintained stable serum sodium, potassium, and creatinine over this period and remained out of the hospital for more than 30 days. Thus, patients hospitalized with acute decompensated heart failure due to volume overload can achieve euvolemia rapidly and without electrolytes disturbances using this regimen, while being under the close supervision of a team of cardiologists and nephrologists. Additionally, this therapy can potentially decrease the need for ultrafiltration and the length of hospital stay.

  5. Triple Diuretics and Aquaretic Strategy for Acute Decompensated Heart Failure due to Volume Overload

    Science.gov (United States)

    Estrada, Chelsea; Patel, Sagar; Weisfelner Bloom, Michelle; Wadhwa, Nand K.

    2013-01-01

    Diuretics, including furosemide, metolazone, and spironolactone, have historically been the mainstay of therapy for acute decompensated heart failure patients. The addition of an aquaretic-like vasopressin antagonist may enhance diuresis further. However, clinical experience with this quadruple combination is lacking in the acute setting. We present two hospitalized patients with acute decompensated heart failure due to massive fluid overload treated with a combination strategy of triple diuretics in conjunction with the aquaretic tolvaptan. The first patient lost 72.1 lbs. (32.7 kg) with an average urine output of 3.5 to 7.5 L/day over eight days on combined therapy with furosemide, metolazone, spironolactone, and tolvaptan. The second patient similarly achieved a weight loss of 28.2 lbs. (12.8 kg) over 4 days on the same treatment. Both patients maintained stable serum sodium, potassium, and creatinine over this period and remained out of the hospital for more than 30 days. Thus, patients hospitalized with acute decompensated heart failure due to volume overload can achieve euvolemia rapidly and without electrolytes disturbances using this regimen, while being under the close supervision of a team of cardiologists and nephrologists. Additionally, this therapy can potentially decrease the need for ultrafiltration and the length of hospital stay. PMID:24829808

  6. Modeling Forensic Evidence Systems Using Design Science

    OpenAIRE

    Armstrong, Colin; Armstrong, Helen

    2010-01-01

    International audience; This paper presents an overview of the application of design science research to the tactical management of forensic evidence processing. The opening discussion addresses the application of design science techniques to specific socio-technical information systems research in regard to processing forensic evidence. The discussion then presents the current problems faced by those dealing with evidence and a conceptual meta-model for a unified approach to forensic evidenc...

  7. Health systems integration: state of the evidence

    Directory of Open Access Journals (Sweden)

    Gail D. Armitage

    2009-06-01

    Full Text Available Introduction: Integrated health systems are considered a solution to the challenge of maintaining the accessibility and integrity of healthcare in numerous jurisdictions worldwide. However, decision makers in a Canadian health region indicated they were challenged to find evidence-based information to assist with the planning and implementation of integrated healthcare systems. Methods: A systematic literature review of peer-reviewed literature from health sciences and business databases, and targeted grey literature sources. Results: Despite the large number of articles discussing integration, significant gaps in the research literature exist. There was a lack of high quality, empirical studies providing evidence on how health systems can improve service delivery and population health. No universal definition or concept of integration was found and multiple integration models from both the healthcare and business literature were proposed in the literature. The review also revealed a lack of standardized, validated tools that have been systematically used to evaluate integration outcomes. This makes measuring and comparing the impact of integration on system, provider and patient level challenging. Discussion and conclusion: Healthcare is likely too complex for a one-size-fits-all integration solution. It is important for decision makers and planners to choose a set of complementary models, structures and processes to create an integrated health system that fits the needs of the population across the continuum of care. However, in order to have evidence available, decision makers and planners should include evaluation for accountability purposes and to ensure a better understanding of the effectiveness and impact of health systems integration.

  8. Explicit Evidence Systems with Common Knowledge

    CERN Document Server

    Bucheli, Samuel; Studer, Thomas

    2010-01-01

    Justification logics are epistemic logics that explicitly include justifications for the agents' knowledge. We develop a multi-agent justification logic with evidence terms for individual agents as well as for common knowledge. We define a Kripke-style semantics that is similar to Fitting's semantics for the Logic of Proofs LP. We show the soundness, completeness, and finite model property of our multi-agent justification logic with respect to this Kripke-style semantics. We demonstrate that our logic is a conservative extension of Yavorskaya's minimal bimodal explicit evidence logic, which is a two-agent version of LP. We discuss the relationship of our logic to the multi-agent modal logic S4 with common knowledge. Finally, we give a brief analysis of the coordinated attack problem in the newly developed language of our logic.

  9. Memory Systems, Processing Modes, and Components: Functional Neuroimaging Evidence

    Science.gov (United States)

    Cabeza, Roberto; Moscovitch, Morris

    2013-01-01

    In the 1980s and 1990s, there was a major theoretical debate in the memory domain regarding the multiple memory systems and processing modes frameworks. The components of processing framework argued for a middle ground: Instead of neatly divided memory systems or processing modes, this framework proposed the existence of numerous processing components that are recruited in different combinations by memory tasks and yield complex patterns of associations and dissociations. Because behavioral evidence was not sufficient to decide among these three frameworks, the debate was largely abandoned. However, functional neuroimaging evidence accumulated during the last two decades resolves the stalemate, because this evidence is more consistent with the components framework than with the other two frameworks. For example, functional neuroimaging evidence shows that brain regions attributed to one memory system can contribute to tasks associated with other memory systems and that brain regions attributed to the same processing mode (perceptual or conceptual) can be dissociated from each other. Functional neuroimaging evidence suggests that memory processes are supported by transient interactions between a few regions called process-specific alliances. These conceptual developments are an example of how functional neuroimaging can contribute to theoretical debates in cognitive psychology. PMID:24163702

  10. ADDIS: A decision support system for evidence-based medicine

    NARCIS (Netherlands)

    G. van Valkenhoef (Gert); T. Tervonen (Tommi); T. Zwinkels (Tijs); B. de Brock (Bert); H.L. Hillege (Hans)

    2013-01-01

    textabstractClinical trials are the main source of information for the efficacy and safety evaluation of medical treatments. Although they are of pivotal importance in evidence-based medicine, there is a lack of usable information systems providing data-analysis and decision support capabilities for

  11. Evidence and control of bifurcations in a respiratory system

    Energy Technology Data Exchange (ETDEWEB)

    Goldin, Matías A., E-mail: mgoldin@df.uba.ar; Mindlin, Gabriel B. [Laboratorio de Sistemas Dinámicos, IFIBA y Departamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 1, Ciudad Universitaria, Buenos Aires (Argentina)

    2013-12-15

    We studied the pressure patterns used by domestic canaries in the production of birdsong. Acoustically different sound elements (“syllables”) were generated by qualitatively different pressure gestures. We found that some ubiquitous transitions between syllables can be interpreted as bifurcations of a low dimensional dynamical system. We interpreted these results as evidence supporting a model in which different timescales interact nonlinearly.

  12. Evidence for Whom? ASHA's National Outcomes Measurement System

    Science.gov (United States)

    Mullen, Robert

    2004-01-01

    The growth of managed care and increasing demands by school systems resulted in of a number of new audiences looking for the evidence underlying the practice of speech-language pathology (SLP). Third-party payers, operating in an environment emphasizing ''return-on-investment,'' sought data linking expenditures on SLP services with tangible…

  13. Criminal Evidence : Democracy, Relevance to the Implementation of Accusatory System and Efficiency of the Oral Evidence

    OpenAIRE

    Domingues, Ricardo Alves; Avila, Gustavo Noronha de

    2016-01-01

    The so-called principle of real truth is argument to justify arbitrary procedures used in criminal proceedings. A perfect reproduction of the scene of a crime is impossible. The production of evidence in democratic societies must be guided by the adversarial system . However, not enough positivization affections precepts to this systematic procedure. It is necessary that the practice of instruction acts reveal democratic conduct by the authorities responsible for conducting the process. Only ...

  14. Characterization of Evidence for Human System Risk Assessment

    Science.gov (United States)

    Steinberg, S. L.; Van Baalen, M.; Rossi, M.; Riccio, G.; Romero, E.; Francisco, D.

    2016-01-01

    Understanding the kinds of evidence available and using the best evidence to answer a question is critical to evidenced-based decision-making, and it requires synthesis of evidence from a variety of sources. Categorization of human system risks in spaceflight, in particular, focuses on how well the integration and interpretation of all available evidence informs the risk statement that describes the relationship between spaceflight hazards and an outcome of interest. A mature understanding and categorization of these risks requires: 1) sufficient characterization of risk, 2) sufficient knowledge to determine an acceptable level of risk (i.e., a standard), 3) development of mitigations to meet the acceptable level of risk, and 4) identification of factors affecting generalizability of the evidence to different design reference missions. In the medical research community, evidence is often ranked by increasing confidence in findings gleaned from observational and experimental research (e.g., "levels of evidence"). However, an approach based solely on aspects of experimental design is problematic in assessing human system risks for spaceflight. For spaceflight, the unique challenges and opportunities include: (1) The independent variables in most evidence are the hazards of spaceflight, such as space radiation or low gravity, which cannot be entirely duplicated in terrestrial (Earth-based) analogs, (2) Evidence is drawn from multiple sources including medical and mission operations, Lifetime Surveillance of Astronaut Health (LSAH), spaceflight research (LSDA), and relevant environmental & terrestrial databases, (3) Risk metrics based primarily on LSAH data are typically derived from available prevalence or incidence data, which may limit rigorous interpretation, (4) The timeframe for obtaining adequate spaceflight sample size (n) is very long, given the small population, (5) Randomized controlled trials are unattainable in spaceflight, (6) Collection of personal and

  15. Informed Systems: Enabling Collaborative Evidence Based Organizational Learning

    Directory of Open Access Journals (Sweden)

    Mary M. Somerville

    2015-12-01

    Full Text Available Objective – In response to unrelenting disruptions in academic publishing and higher education ecosystems, the Informed Systems approach supports evidence based professional activities to make decisions and take actions. This conceptual paper presents two core models, Informed Systems Leadership Model and Collaborative Evidence-Based Information Process Model, whereby co-workers learn to make informed decisions by identifying the decisions to be made and the information required for those decisions. This is accomplished through collaborative design and iterative evaluation of workplace systems, relationships, and practices. Over time, increasingly effective and efficient structures and processes for using information to learn further organizational renewal and advance nimble responsiveness amidst dynamically changing circumstances. Methods – The integrated Informed Systems approach to fostering persistent workplace inquiry has its genesis in three theories that together activate and enable robust information usage and organizational learning. The information- and learning-intensive theories of Peter Checkland in England, which advance systems design, stimulate participants’ appreciation during the design process of the potential for using information to learn. Within a co-designed environment, intentional social practices continue workplace learning, described by Christine Bruce in Australia as informed learning enacted through information experiences. In addition, in Japan, Ikujiro Nonaka’s theories foster information exchange processes and knowledge creation activities within and across organizational units. In combination, these theories promote the kind of learning made possible through evolving and transferable capacity to use information to learn through design and usage of collaborative communication systems with associated professional practices. Informed Systems therein draws from three antecedent theories to create an original

  16. Granular biodurable nanomaterials: No convincing evidence for systemic toxicity.

    Science.gov (United States)

    Moreno-Horn, Marcus; Gebel, Thomas

    2014-11-01

    Nanomaterials are usually defined by primary particle diameters ranging from 1 to 100 nm. The scope of this review is an evaluation of experimental animal studies dealing with the systemic levels and putative systemic effects induced by nanoparticles which can be characterized as being granular biodurable particles without known specific toxicity (GBP). Relevant examples of such materials comprise nanosized titanium dioxide (TiO2) and carbon black. The question was raised whether GBP nanomaterials systemically accumulate and may possess a relevant systemic toxicity. With few exceptions, the 56 publications reviewed were not performed using established standard protocols, for example, OECD guidelines but used non-standard study designs. The studies including kinetic investigations indicated that GBP nanomaterials were absorbed and systemically distributed to rather low portions only. There was no valid indication that GPB nanomaterials possess novel toxicological hazard properties. In addition, no convincing evidence for a relevant specific systemic toxicity of GBP nanomaterials could be identified. The minority of the papers reviewed (15/56) investigated both nanosized and microsized GBP materials in parallel. A relevant different translocation of GBP nanomaterials in contrast to GBP micromaterials was not observed in these studies. There was no evidence that GPB nanomaterials possess toxicological properties other than their micromaterial counterparts.

  17. Guidance for evidence-informed policies about health systems: assessing how much confidence to place in the research evidence.

    Science.gov (United States)

    Lewin, Simon; Bosch-Capblanch, Xavier; Oliver, Sandy; Akl, Elie A; Vist, Gunn E; Lavis, John N; Ghersi, Davina; Røttingen, John-Arne; Steinmann, Peter; Gulmezoglu, Metin; Tugwell, Peter; El-Jardali, Fadi; Haines, Andy

    2012-01-01

    In the third paper in a three-part series on health systems guidance, Simon Lewin and colleagues explore the challenge of assessing how much confidence to place in evidence on health systems interventions.

  18. Guidance for evidence-informed policies about health systems: assessing how much confidence to place in the research evidence.

    Directory of Open Access Journals (Sweden)

    Simon Lewin

    Full Text Available In the third paper in a three-part series on health systems guidance, Simon Lewin and colleagues explore the challenge of assessing how much confidence to place in evidence on health systems interventions.

  19. Complex systems dynamics in aging: new evidence, continuing questions.

    Science.gov (United States)

    Cohen, Alan A

    2016-02-01

    There have long been suggestions that aging is tightly linked to the complex dynamics of the physiological systems that maintain homeostasis, and in particular to dysregulation of regulatory networks of molecules. This review synthesizes recent work that is starting to provide evidence for the importance of such complex systems dynamics in aging. There is now clear evidence that physiological dysregulation--the gradual breakdown in the capacity of complex regulatory networks to maintain homeostasis--is an emergent property of these regulatory networks, and that it plays an important role in aging. It can be measured simply using small numbers of biomarkers. Additionally, there are indications of the importance during aging of emergent physiological processes, functional processes that cannot be easily understood through clear metabolic pathways, but can nonetheless be precisely quantified and studied. The overall role of such complex systems dynamics in aging remains an important open question, and to understand it future studies will need to distinguish and integrate related aspects of aging research, including multi-factorial theories of aging, systems biology, bioinformatics, network approaches, robustness, and loss of complexity.

  20. Catchment systems science and management: from evidence to resilient landscapes

    Science.gov (United States)

    Quinn, Paul

    2014-05-01

    There is an urgent need to reassess both the scientific understanding and the policy making approaches taken to manage flooding, water scarcity and pollution in intensively utilised catchments. Many European catchments have been heavily modified and natural systems have largely disappeared. However, working with natural processes must still be at the core of any future management strategy. Many catchments have greatly reduced infiltration rates and buffering capacity and this process needs to be reversed. An interventionist and holistic approach to managing water quantity and quality at the catchment scale is urgently required through the active manipulation of natural flow processes. Both quantitative (field experiments and modelling) and qualitative evidence (local knowledge) is required to demonstrate that catchment have become 'unhealthy'. For example, dense networks of low cost instrumentation could provide this multiscale evidence and, coupled with stakeholder knowledge, build a comprehensive understanding of whole system function. Proactive Catchment System Management is an interventionist approach to altering the catchment scale runoff regime through the manipulation of landscape scale hydrological flow pathways. Many of the changes to hydrological processes cannot be detected at the catchment scale as the primary causes of flooding and pollution. Evidence shows it is the land cover and the soil that are paramount to any change. Local evidence shows us that intense agricultural practices reduce the infiltration capacity through soil degradation. The intrinsic buffering capacity has also been lost across the landscape. The emerging hydrological process is one in which the whole system responds too quickly (driven by near surface and overland flow processes). The bulk of the soil matrix is bypassed during storm events and there is little or no buffering capacity in the riparian areas or in headwater catchments. The prospect of lower intensity farming rates is

  1. Combination of evidence in recommendation systems characterized by distance functions

    Energy Technology Data Exchange (ETDEWEB)

    Rocha, L. M. (Luis Mateus)

    2002-01-01

    Recommendation systems for different Document Networks (DN) such as the World Wide Web (WWW), Digitnl Libarries, or Scientific Databases, often make use of distance functions extracted from relationships among documents and between documents and semantic tags. For instance, documents In the WWW are related via a hyperlink network, while documents in bibliographic databases are related by citation and collaboration networks.Furthermore, documents can be related to semantic tags such as keywords used to describe their content, The distance functions computed from these relations establish associative networks among items of the DN, and allow recommendation systems to identify relevant associations for iudividoal users. The process of recommendation can be improved by integrating associative data from different sources. Thus we are presented with a problem of combining evidence (about assochaons between items) from different sonrces characterized by distance functions. In this paper we summarize our work on (1) inferring associations from semi-metric distance functions and (2) combining evidence from different (distance) associative DN.

  2. 75 FR 78269 - Vehicular Digital Multimedia Evidence Recording System (VDMERS) Standard for Law Enforcement

    Science.gov (United States)

    2010-12-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Office of Justice Programs Vehicular Digital Multimedia Evidence Recording System (VDMERS) Standard for Law... the general public the draft ``Vehicular Digital Multimedia Evidence Recording System Standard for...

  3. 76 FR 27355 - Law Enforcement Vehicular Digital Multimedia Evidence Recording System Selection and Application...

    Science.gov (United States)

    2011-05-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Office of Justice Programs Law Enforcement Vehicular Digital Multimedia Evidence Recording System Selection... public, the ``Law Enforcement Vehicular Digital Multimedia Evidence Recording System Selection...

  4. 76 FR 13436 - NIJ Request for Comments on Draft Vehicular Digital Multimedia Evidence Recording System...

    Science.gov (United States)

    2011-03-11

    ... Digital Multimedia Evidence Recording System Selection and Application Guide AGENCY: National Institute of... Vehicular Digital Multimedia Evidence Recording System Selection and Application Guide'' The opportunity to... Office of Justice Programs NIJ Request for Comments on Draft Vehicular Digital Multimedia...

  5. 76 FR 52350 - Vehicular Digital Multimedia Evidence Recording System (VDMERS) Standard, Certification Program...

    Science.gov (United States)

    2011-08-22

    ... of Justice Programs Vehicular Digital Multimedia Evidence Recording System (VDMERS) Standard...) will make available to the general public three draft documents related to Vehicular Digital Multimedia Evidence Recording Systems (VDMERSs) used by law enforcement agencies: 1. Draft VDMERS Standard for...

  6. Disease-related malnutrition in systemic sclerosis: evidences and implications.

    Science.gov (United States)

    Codullo, Veronica; Cereda, Emanuele; Crepaldi, Gloria; Cappello, Silvia; Montecucco, Carlomaurizio; Caccialanza, Riccardo; Caporali, Roberto

    2015-01-01

    The present review summarises evidences and provides recommendations for the screening and management of malnutrition in systemic sclerosis (SSc). This complication is frequently under-estimated when assessing patients and this may lead to an impaired estimation of prognosis. The presence of malnutrition is indicated by anthropometric and biohumoral changes reflecting protein stores (low serum prealbumin) and influenced by organ involvement in SSc (skin and the gastrointestinal tract). Patients at high risk of malnutrition or with low prealbumin levels have shown increased mortality risk and, therefore, a nutritional assessment is mandatory in every SSc patient. This screening is especially important as malnutrition represents a potentially modifiable risk factor with nutritional interventions. The pillars of nutritional treatment are also discussed.

  7. Evidence for Terrestrial Planetary System Remnants at White Dwarfs

    CERN Document Server

    Farihi, J

    2010-01-01

    The last several years have brought about a dynamic shift in the view of exoplanetary systems in the post-main sequence, perhaps epitomized by the evidence for surviving rocky planetary bodies at white dwarfs. Coinciding with the launch of the Spitzer Space Telescope, both space- and ground-based data have supported a picture whereby asteroid analogs persist at a significant fraction of cool white dwarfs, and are prone to tidal disruption when passing close to the compact stellar remnant. The ensuing debris can produce a detectable infrared excess, and the material gradually falls onto the star, polluting the atmosphere with heavy elements that can be used to determine the bulk composition of the destroyed planetary body. Based on the observations to date, the parent bodies inferred at white dwarfs are best described as asteroids, and have a distinctly rocky composition similar to material found in the inner Solar System. Their minimum masses are typical of large asteroids, and can approach or exceed the mass...

  8. Observational Evidence for Tidal Interaction in Close Binary Systems

    CERN Document Server

    Mazeh, Tsevi

    2008-01-01

    This paper reviews the rich corpus of observational evidence for tidal effects in short-period binaries. We review the evidence for ellipsoidal variability and for the observational manifestation of apsidal motion in eclipsing binaries. Among the long-term effects, circularization was studied the most, and a transition period between circular and eccentric orbits has been derived for eight coeval samples of binaries. As binaries are supposed to reach synchronization before circularization, one can expect finding eccentric binaries in pseudo-synchronization state, the evidence for which is reviewed. The paper reviews the Rossiter-McLaughlin effect and its potential to study spin-orbit alignment. We discuss the tidal interaction in close binaries that are orbited by a third distant companion, and review the effect of pumping the binary eccentricity by the third star. We then discuss the idea that the tidal interaction induced by the eccentricity modulation can shrink the binary separation. The paper discusses t...

  9. Comparison of consumer derived evidence with an omaha system evidence-based practice guideline for community dwelling older adults.

    Science.gov (United States)

    Pruinelli, Lisiane; Fu, Helen; Monsen, Karen A; Westra, Bonnie L

    2014-01-01

    Consumer involvement in healthcare is critical to support continuity of care for consumers to manage their health while transitioning from one care setting to another. Validation of evidence-based practice (EBP) guideline by consumers is essential to achieving consumer health goals over time that is consistent with their needs and preferences. The purpose of this study was to compare an Omaha System EBP guideline for community dwelling older adults with consumer-derived evidence of their ongoing needs, resources, and strategies after home care discharge. All identified problems were relevant for all patients except for Neglect and Substance use. Ten additional problems were identified from the interviews, five of which affected at least 10% of the participants. Consumer derived evidence both validated and expanded EBP guidelines; thus further emphasizing the importance of consumer involvement in the delivery of home healthcare.

  10. Do Employers Prefer Undocumented Workers? Evidence from China's Hukou System

    OpenAIRE

    Kuhn, Peter J.; Shen, Kailing

    2014-01-01

    We study urban Chinese employers' preferences between workers with and without a local residence permit (hukou) using callback information from an Internet job board serving private sector employers. We find that employers prefer migrant workers to locals who are identically matched to the job's requirements; these preferences are especially strong at low skill levels. We argue that migrants' higher work hours and effort help to account for employers' preferences, and present evidence that ef...

  11. The evidence-base for family therapy and systemic interventions for child-focused problems

    OpenAIRE

    Carr, Alan

    2014-01-01

    This review updates similar articles published in the Journal of Family Therapy in 2001 and 2009. It presents evidence from meta-analyses, systematic literature reviews and controlled trials for the effectiveness of systemic interventions for families of children and adolescents with various difficulties. In this context, systemic interventions include both family therapy and other family-based approaches such as parent training. The evidence supports the effectiveness of systemic interventio...

  12. Use of health systems evidence by policymakers in eastern mediterranean countries: views, practices, and contextual influences

    Directory of Open Access Journals (Sweden)

    El-Jardali Fadi

    2012-07-01

    Full Text Available Abstract Background Health systems evidence can enhance policymaking and strengthen national health systems. In the Middle East, limited research exists on the use of evidence in the policymaking process. This multi-country study explored policymakers’ views and practices regarding the use of health systems evidence in health policymaking in 10 eastern Mediterranean countries, including factors that influence health policymaking and barriers and facilitators to the use of evidence. Methods This study utilized a survey adapted and customized from a similar tool developed in Canada. Health policymakers from 10 countries (Algeria, Bahrain, Jordan, Lebanon Oman, Pakistan, Palestine, Sudan, Tunisia, and Yemen were surveyed. Descriptive and bi-variate analyses were performed for quantitative questions and thematic analysis was done for qualitative questions. Results A total of 237 policymakers completed the survey (56.3% response rate. Governing parties, limited funding for the health sector and donor organizations exerted a strong influence on policymaking processes. Most (88.5% policymakers reported requesting evidence and 43.1% reported collaborating with researchers. Overall, 40.1% reported that research evidence is not delivered at the right time. Lack of an explicit budget for evidence-informed health policymaking (55.3%, lack of an administrative structure for supporting evidence-informed health policymaking processes (52.6%, and limited value given to research (35.9% all limited the use of research evidence. Barriers to the use of evidence included lack of research targeting health policy, lack of funding and investments, and political forces. Facilitators included availability of health research and research institutions, qualified researchers, research funding, and easy access to information. Conclusions Health policymakers in several countries recognize the importance of using health systems evidence. Study findings are important in light

  13. [GRADE system: classification of quality of evidence and strength of recommendation].

    Science.gov (United States)

    Aguayo-Albasini, José Luis; Flores-Pastor, Benito; Soria-Aledo, Víctor

    2014-02-01

    The acquisition and classification of scientific evidence, and subsequent formulation of recommendations constitute the basis for the development of clinical practice guidelines. There are several systems for the classification of evidence and strength of recommendations; the most commonly used nowadays is the Grading of Recommendations, Assessment, Development and Evaluation system (GRADE). The GRADE system initially classifies the evidence into high or low, coming from experimental or observational studies; subsequently and following a series of considerations, the evidence is classified into high, moderate, low or very low. The strength of recommendations is based not only on the quality of the evidence, but also on a series of factors such as the risk/benefit balance, values and preferences of the patients and professionals, and the use of resources or costs.

  14. Neurobehavioral evidence for changes in dopamine system activity during adolescence.

    Science.gov (United States)

    Wahlstrom, Dustin; White, Tonya; Luciana, Monica

    2010-04-01

    Human adolescence has been characterized by increases in risk-taking, emotional lability, and deficient patterns of behavioral regulation. These behaviors have often been attributed to changes in brain structure that occur during this developmental period, notably alterations in gray and white matter that impact synaptic architecture in frontal, limbic, and striatal regions. In this review, we provide a rationale for considering that these behaviors may be due to changes in dopamine system activity, particularly overactivity, during adolescence relative to either childhood or adulthood. This rationale relies on animal data due to limitations in assessing neurochemical activity more directly in juveniles. Accordingly, we also present a strategy that incorporates molecular genetic techniques to infer the status of the underlying tone of the dopamine system across developmental groups. Implications for the understanding of adolescent behavioral development are discussed.

  15. Concordium 2015: Strategic Uses of Evidence to Transform Delivery Systems.

    Science.gov (United States)

    Holve, Erin; Weiss, Samantha

    2016-01-01

    In September 2015 the EDM Forum hosted AcademyHealth's newest national conference, Concordium. The 11 papers featured in the eGEMs "Concordium 2015" special issue successfully reflect the major themes and issues discussed at the meeting. Many of the papers address informatics or methodological approaches to natural language processing (NLP) or text analysis, which is indicative of the importance of analyzing text data to gain insights into care coordination and patient-centered outcomes. Perspectives on the tools and infrastructure requirements that are needed to build learning health systems were also recurrent themes.

  16. Surveillance, response systems, and evidence updates on emerging zoonoses: the role of one health

    OpenAIRE

    2013-01-01

    Globally, emerging zoonotic diseases are increasing. Existing surveillance systems for zoonoses have substantial gaps, especially in developing countries, and the systems in place in the developed world require improvements. Resources and updates on evidence-based practice (EBP) for zoonoses are sparser in the veterinary literature as compared to the medical literature. Evidence updates for emerging zoonoses are either absent or rudimentary in both human and veterinary medicine. A ‘one-health...

  17. Evidence for nonlinear capacitance in biomembrane channel system.

    Science.gov (United States)

    Ghosh, S; Bera, A K; Das, S

    1999-10-01

    The electrophysiological properties of voltage-dependent anion channels from mitochondrial membrane have been studied in a bilayer membrane system. It was observed that the probability of opening of the membrane channel depends on externally applied voltage and the plot is a bell-shaped curve symmetric around probability axis. A scheme of conformational energy levels under varying externally applied voltage was formulated. Assuming that the probability follows Boltzmann distribution, we arrive at an expression of change in energy containing a separate term identical to the energy of a capacitor. This fact indicates the possibility of existence of an added capacitance due to the channel protein. Further it was shown that the aforesaid channel capacitor could be a function of voltage leading to nonlinearity. We have offered a general method of calculating nonlinear capacitance from the experimental data on opening probability of a membrane channel. In case of voltage-dependent anion channel the voltage dependence of the capacitor has a power 0.786. The results have been interpreted in view of the structural organization of the channel protein in the membrane. Our hypothesis is that the phenomenon of capacitor behaviour is a general one for membrane channels.

  18. Evidence for universality in phenomenological emotion response system coherence.

    Science.gov (United States)

    Matsumoto, David; Nezlek, John B; Koopmann, Birgit

    2007-02-01

    The authors reanalyzed data from Scherer and Wallbott's (Scherer, 1997b; Scherer & Wallbott, 1994) International Study of Emotion Antecedents and Reactions to examine how phenomenological reports of emotional experience, expression, and physiological sensations were related to each other within cultures and to determine if these relationships were moderated by cultural differences, which were operationally defined using Hofstede's (2001) typology. Multilevel random coefficient modeling analyses produced several findings of note. First, the vast majority of the variance in ratings was within countries (i.e., at the individual level); a much smaller proportion of the total variance was between countries. Second, there were negative relationships between country-level means and long- versus short-term orientation for numerous measures. Greater long-term orientation was associated with lowered emotional expressivity and fewer physiological sensations. Third, at the individual (within-culture) level, across the 7 emotions, there were consistent and reliable positive relationships among the response systems, indicating coherence among them. Fourth, such relationships were not moderated by cultural differences, as measured by the Hofstede dimensions.

  19. [Refractory ascites and dilutional hyponatremia: current management and new aquaretics].

    Science.gov (United States)

    Torre Delgadillo, Aldo

    2005-01-01

    Ascites is the most common complication of cirrhosis and is associated with 50% mortality at 2 years if patients do not receive orthotopic liver transplantation. Recently the International Ascites Club defined ascites into three groups: In grade I ascites fluid is detected only by ultrasound; in grade II, ascites is moderate with symmetrical distention of the abdomen; and in Grade 3 ascites is large or tense with marked abdominal distention. About 10% of patients with ascites are refractory to treatment with diuretics. In refractory ascites, patients do not respond to highest doses of diuretics (spironolactone 400 mg/day and furosemide 160 mg/ day) or develop side effects (hyperkalemia, hyponatremia, hepatic encephalopathy, or renal failure) that prohibit their use. Patients may be treated either by repeated large volume paracentesis plus albumin or transjugular intrahepatic portosystemic shunts (TIPS). Dilutional hyponatremia in cirrhotic patients is defined as serum sodium < or = 130 mEq/L in the presence of an expanded extracellular fluid volume, as indicated by the presence of ascites and/or edema. This complication of cirrhotic patients with ascites has recently gained attention given that several reports indicate that when serum sodium concentration is combined with the Model for End-Stage liver disease (MELD) it improves the prognostic accuracy of MELD score in patients awaiting orthotopic liver transplant (OLT). The first step in the management of dilutional hyponatremia is fluid restriction and discontinuation of diuretics. Water restriction at 1,000 mL/day helps prevent the progressive decrease in serum sodium concentration but usually does not correct hyponatremia in most cases. Actually are developing drugs that are active orally and act by selectively antagonizing the specific receptors (V2 receptor) of arginine vasopressin. These agents act in the distal collecting ducts of the kidneys, by increasing solute free water excretion and, thus, improving serum sodium concentration in hyponatremic patients.

  20. [Scientific evidence and the cost of innovations in the health-care system].

    Science.gov (United States)

    Porzsolt, Franz; Schreyögg, Jonas

    2009-08-01

    When depicting the relationship between evidence and the cost of an innovation in the health-care system, the overall risks of assessment, the redistribution of risks in a regulated market, and the ethical consequences must first be taken into account. There are also evidence-based criteria and economic considerations which are relevant when calculating the cost of an innovation. These topics can indicate, but not exhaustively deal with the complicated relationship between scientific evidence and calculating the cost of an innovation in the health-care system. The following three statements summarize the current considerations in the continuing discussion of this topic: *Scientific evidence undoubtedly exists which should be taken into consideration when calculating the cost of an innovation in the health-care system. *The existing scientific evidence is, however, not sufficient to reach such a decision. Additional information about the benefit perceived by the patient is required. *No standardized method exists to measure this additional information. Therefore, a definition problem also exists in the health-care system when setting a price according to scientific evidence.

  1. Surveillance, response systems, and evidence updates on emerging zoonoses: the role of one health.

    Science.gov (United States)

    Asokan, G V; Kasimanickam, Ramanathan K; Asokan, Vanitha

    2013-01-01

    Globally, emerging zoonotic diseases are increasing. Existing surveillance systems for zoonoses have substantial gaps, especially in developing countries, and the systems in place in the developed world require improvements. Resources and updates on evidence-based practice (EBP) for zoonoses are sparser in the veterinary literature as compared to the medical literature. Evidence updates for emerging zoonoses are either absent or rudimentary in both human and veterinary medicine. A 'one-health' concept, including a global signaling surveillance system for emerging zoonoses, will be essential for correct diagnoses, interventions, and public health strategies. An open access EBP platform supported by builders of EBP resources is urgently needed to counter emerging zoonoses.

  2. Health Professionals' Use of Online Information Retrieval Systems and Online Evidence.

    Science.gov (United States)

    Lialiou, Paschalina; Pavlopoulou, Ioanna; Mantas, John

    2016-01-01

    Across-sectional survey was designed to determine health professionals' awareness and usage of online evidence retrieval systems in clinical practice. A questionnaire was used to measure professionals' behavior and utilization of online evidences, as well as, reasons and barriers on information retrieval. 439 nurses and physicians from public and private hospitals in Greece formulate the study's sample. The two most common reasons that individuals are using online information systems were for writing scientific manuscripts or filling a knowledge gap. A positive correlation was found between participants with postgraduate studies and information system usage. The majority of them (90,6%) believe that online information systems improves patient care and 67,6% of them had their own experiences on this. More support is needed to nurses and physicians in order to use the online evidence and as a result to improve the provided care and practices.

  3. What is the Role of Legal Systems in Financial Intermediation? Theory and Evidence

    NARCIS (Netherlands)

    Bottazzi, L.; Da Rin, M.; Hellmann, T.

    2008-01-01

    We develop a theory and empirical test of how the legal system affects the relationship between venture capitalists and entrepreneurs. The theory uses a double moral hazard framework to show how optimal contracts and investor actions depend on the quality of the legal system. The empirical evidence

  4. Systems for grading the quality of evidence and the strength of recommendations II: Pilot study of a new system

    Directory of Open Access Journals (Sweden)

    Oxman Andrew D

    2005-03-01

    Full Text Available Abstract Background Systems that are used by different organisations to grade the quality of evidence and the strength of recommendations vary. They have different strengths and weaknesses. The GRADE Working Group has developed an approach that addresses key shortcomings in these systems. The aim of this study was to pilot test and further develop the GRADE approach to grading evidence and recommendations. Methods A GRADE evidence profile consists of two tables: a quality assessment and a summary of findings. Twelve evidence profiles were used in this pilot study. Each evidence profile was made based on information available in a systematic review. Seventeen people were given instructions and independently graded the level of evidence and strength of recommendation for each of the 12 evidence profiles. For each example judgements were collected, summarised and discussed in the group with the aim of improving the proposed grading system. Kappas were calculated as a measure of chance-corrected agreement for the quality of evidence for each outcome for each of the twelve evidence profiles. The seventeen judges were also asked about the ease of understanding and the sensibility of the approach. All of the judgements were recorded and disagreements discussed. Results There was a varied amount of agreement on the quality of evidence for the outcomes relating to each of the twelve questions (kappa coefficients for agreement beyond chance ranged from 0 to 0.82. However, there was fair agreement about the relative importance of each outcome. There was poor agreement about the balance of benefits and harms and recommendations. Most of the disagreements were easily resolved through discussion. In general we found the GRADE approach to be clear, understandable and sensible. Some modifications were made in the approach and it was agreed that more information was needed in the evidence profiles. Conclusion Judgements about evidence and recommendations are

  5. Road Safety Effects of Bus Rapid Transit (BRT) Systems: a Call for Evidence.

    Science.gov (United States)

    Vecino-Ortiz, Andres I; Hyder, Adnan A

    2015-10-01

    Road injuries are an important cause of global mortality especially in low- and middle-income countries. While these countries undergo major urban transformations, an integral part of their development has often been the implementation of mass transportation systems, including Bus Rapid Transit (BRT) systems. However, the net effect of BRT systems on road safety is still unclear, and while there is reason to believe that BRT systems improve safety, very few available empirical studies have tested this hypothesis using observational data. Furthermore, the existing evidence is mixed and sparse. This paper reviews the available literature on the links of BRT systems and road safety and calls for more research to strengthen the body of evidence on the effect of BRT systems on road safety  in the future.

  6. Scientific evidence-based effects of hydrotherapy on various systems of the body.

    Science.gov (United States)

    Mooventhan, A; Nivethitha, L

    2014-05-01

    The use of water for various treatments (hydrotherapy) is probably as old as mankind. Hydrotherapy is one of the basic methods of treatment widely used in the system of natural medicine, which is also called as water therapy, aquatic therapy, pool therapy, and balneotherapy. Use of water in various forms and in various temperatures can produce different effects on different system of the body. Many studies/reviews reported the effects of hydrotherapy only on very few systems and there is lack of studies/reviews in reporting the evidence-based effects of hydrotherapy on various systems. We performed PubMed and PubMed central search to review relevant articles in English literature based on "effects of hydrotherapy/balneotherapy" on various systems of the body. Based on the available literature this review suggests that the hydrotherapy has a scientific evidence-based effect on various systems of the body.

  7. Scientific evidence-based effects of hydrotherapy on various systems of the body

    Directory of Open Access Journals (Sweden)

    A Mooventhan

    2014-01-01

    Full Text Available The use of water for various treatments (hydrotherapy is probably as old as mankind. Hydrotherapy is one of the basic methods of treatment widely used in the system of natural medicine, which is also called as water therapy, aquatic therapy, pool therapy, and balneotherapy. Use of water in various forms and in various temperatures can produce different effects on different system of the body. Many studies/reviews reported the effects of hydrotherapy only on very few systems and there is lack of studies/reviews in reporting the evidence-based effects of hydrotherapy on various systems. We performed PubMed and PubMed central search to review relevant articles in English literature based on "effects of hydrotherapy/balneotherapy" on various systems of the body. Based on the available literature this review suggests that the hydrotherapy has a scientific evidence-based effect on various systems of the body.

  8. Investigation of Ballistic Evidence through an Automatic Image Analysis and Identification System.

    Science.gov (United States)

    Kara, Ilker

    2016-05-01

    Automated firearms identification (AFI) systems contribute to shedding light on criminal events by comparison between different pieces of evidence on cartridge cases and bullets and by matching similar ones that were fired from the same firearm. Ballistic evidence can be rapidly analyzed and classified by means of an automatic image analysis and identification system. In addition, it can be used to narrow the range of possible matching evidence. In this study conducted on the cartridges ejected from the examined pistol, three imaging areas, namely the firing pin impression, capsule traces, and the intersection of these traces, were compared automatically using the image analysis and identification system through the correlation ranking method to determine the numeric values that indicate the significance of the similarities. These numerical features that signify the similarities and differences between pistol makes and models can be used in groupings to make a distinction between makes and models of pistols.

  9. What is evidence-based dentistry, and do oral infections increase systemic morbidity or mortality?

    Science.gov (United States)

    Niederman, Richard; Richards, Derek

    2011-11-01

    From Celsus' first reports of rubor, calor, dolor, tumor, and functio laesa, has come an understanding of inflammation's manifestations at the organ, tissue, vascular, cellular, genetic, and molecular levels. Molecular medicine now raises the opposite question: can local oral infections and their inflammatory mediators increase systemic morbidity or mortality? From these perspectives we examine the clinical evidence relating caries, periodontal disease, and pericoronitis to systemic disease. Widespread affirmation of an oral-systemic linkage remains elusive, raising sobering cautions.

  10. Development and implementation of the Ontario Stroke System: the use of evidence

    Directory of Open Access Journals (Sweden)

    Jill I. Cameron

    2007-08-01

    Full Text Available Introduction The Ontario Stroke System was developed to enhance the quality and continuity of stroke care provided across the care continuum. Research Objective To identify the role evidence played in the development and implementation of the Ontario Stroke System. Methods This study employed a qualitative case study design. In-depth interviews were conducted with six members of the Ontario Stroke System provincial steering committee. Nine focus groups were conducted with: Regional Program Managers, Regional Education Coordinators, and seven acute care teams. To supplement these findings interviews were conducted with eight individuals knowledgeable about national and international models of integrated service delivery. Results Our analyses identified six themes. The first four themes highlight the use of evidence to support the process of system development and implementation including: 1 informing system development; 2 mobilizing governmental support; 3 getting the system up and running; and 4 integrating services across the continuum of care. The final two themes describe the foundation required to support this process: 1 human capacity and 2 mechanisms to share evidence. Conclusion This study provides guidance to support the development and implementation of evidence-based models of integrated service delivery.

  11. A Regional PD Strategy for EPR Systems: Evidence-Based IT Development

    DEFF Research Database (Denmark)

    Simonsen, Jesper; Hertzum, Morten

    2006-01-01

    systems. We present this PD strategy and our related research on evidence-based IT development. We report from a newly completed PD experiment with EPR in the region conducted through a close collaboration compris-ing a neurological stroke unit, the region’s EPR unit, the vendor, as well as the authors.......One of the five regions in Denmark has initiated a remark-able and alternative strategy for the development of Elec-tronic Patient Record (EPR) systems. This strategy is driven by Participatory Design (PD) experiments and based on evidence of positive effects on the clinical practice when using EPR...

  12. Fetal central nervous system development and alcohol--the evidence so far.

    Science.gov (United States)

    Ahmed-Landeryou, Musharrat Jabeen

    2012-12-01

    Currently in the UK, there is no absolute guidance about alcohol consumption in pregnancy. The guidance for drinking during pregnancy is one or two units of alcohol one or two times weekly, but conservative advice is to abstain as a cautionary measure. Despite the lack of consensus about the safe levels of alcohol consumption in pregnancy, there is increasing evidence of the impact of alcohol on the developing central nervous system. This article explores the evidence regarding alcohol consumption and its effects on the developing fetal central nervous system.

  13. Evidence-based practice: cost-benefit of large system implementation.

    Science.gov (United States)

    Schifalacqua, Marita Mackinnon; Shepard, Ann; Kelley, Wanda

    2012-01-01

    The key points for designing and implementing an evidence-based practice (EBP) model in a large health care system are discussed. This implementation created strategies for practice changes for organizational change. The quality management methods included structured EBP toolkits that are described as part of the deliverable of each toolkit's Design Team. The cost-benefit evaluation process of staff time in the development stage of an EBP is explained. The conclusion is that a representative group of clinicians can be leveraged to create the standard and materials for system implementation, thereby providing improved patient care that is evidence-based and cost-effective.Many hands make light work....

  14. Relevance of the glutathione system in temporal lobe epilepsy: evidence in human and experimental models.

    Science.gov (United States)

    Cárdenas-Rodríguez, Noemí; Coballase-Urrutia, Elvia; Pérez-Cruz, Claudia; Montesinos-Correa, Hortencia; Rivera-Espinosa, Liliana; Sampieri, Aristides; Carmona-Aparicio, Liliana

    2014-01-01

    Oxidative stress, which is a state of imbalance in the production of reactive oxygen species and nitrogen, is induced by a wide variety of factors. This biochemical state is associated with diseases that are systemic as well as diseases that affect the central nervous system. Epilepsy is a chronic neurological disorder, and temporal lobe epilepsy represents an estimated 40% of all epilepsy cases. Currently, evidence from human and experimental models supports the involvement of oxidative stress during seizures and in the epileptogenesis process. Hence, the aim of this review was to provide information that facilitates the processing of this evidence and investigate the therapeutic impact of the biochemical status for this specific pathology.

  15. The validation of forensic DNA extraction systems to utilize soil contaminated biological evidence.

    Science.gov (United States)

    Kasu, Mohaimin; Shires, Karen

    2015-07-01

    The production of full DNA profiles from biological evidence found in soil has a high failure rate due largely to the inhibitory substance humic acid (HA). Abundant in various natural soils, HA co-extracts with DNA during extraction and inhibits DNA profiling by binding to the molecular components of the genotyping assay. To successfully utilize traces of soil contaminated evidence, such as that found at many murder and rape crime scenes in South Africa, a reliable HA removal extraction system would often be selected based on previous validation studies. However, for many standard forensic DNA extraction systems, peer-reviewed publications detailing the efficacy on soil evidence is either lacking or is incomplete. Consequently, these sample types are often not collected or fail to yield suitable DNA material due to the use of unsuitable methodology. The aim of this study was to validate the common forensic DNA collection and extraction systems used in South Africa, namely DNA IQ, FTA elute and Nucleosave for processing blood and saliva contaminated with HA. A forensic appropriate volume of biological evidence was spiked with HA (0, 0.5, 1.5 and 2.5 mg/ml) and processed through each extraction protocol for the evaluation of HA removal using QPCR and STR-genotyping. The DNA IQ magnetic bead system effectively removed HA from highly contaminated blood and saliva, and generated consistently acceptable STR profiles from both artificially spiked samples and crude soil samples. This system is highly recommended for use on soil-contaminated evidence over the cellulose card-based systems currently being preferentially used for DNA sample collection.

  16. Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study

    NARCIS (Netherlands)

    Coghlan, J.G.; Denton, C.P.; Grunig, E.; Bonderman, D.; Distler, O.; Khanna, D.; Muller-Ladner, U.; Pope, J.E.; Vonk, M.C.; Doelberg, M.; Chadha-Boreham, H.; Heinzl, H.; Rosenberg, D.M.; McLaughlin, V.V.; Seibold, J.R.

    2014-01-01

    OBJECTIVE: Earlier detection of pulmonary arterial hypertension (PAH), a leading cause of death in systemic sclerosis (SSc), facilitates earlier treatment. The objective of this study was to develop the first evidence-based detection algorithm for PAH in SSc. METHODS: In this cross-sectional, intern

  17. Initial steps towards an evidence-based classification system for golfers with a physical impairment

    NARCIS (Netherlands)

    Stoter, Inge K; Hettinga, Florentina J; Altmann, Viola; Eisma, Wim; Arendzen, Hans; Bennett, Tony; van der Woude, Lucas H; Dekker, Rienk

    2015-01-01

    PURPOSE: The present narrative review aims to make a first step towards an evidence-based classification system in handigolf following the International Paralympic Committee (IPC). It intends to create a conceptual framework of classification for handigolf and an agenda for future research. METHOD:

  18. Initial steps towards an evidence-based classification system for golfers with a physical impairment

    NARCIS (Netherlands)

    Stoter, Inge K.; Hettinga, Florentina J.; Altmann, Viola; Eisma, Wim; Arendzen, Hans; Bennett, Tony; van der Woude, Lucas H.; Dekker, Rienk

    2017-01-01

    Purpose: The present narrative review aims to make a first step towards an evidence-based classification system in handigolf following the International Paralympic Committee (IPC). It intends to create a conceptual framework of classification for handigolf and an agenda for future research. Method:

  19. Bank Systemic Risk-Taking and Loan Pricing : Evidence from Syndicated Loans

    NARCIS (Netherlands)

    Gong, D.

    2014-01-01

    In this paper we document evidence of systemic risk taking from syndicated loan pricing. Using U.S. syndicated loan data, we find that the borrower's idiosyncratic risk is positively priced whereas systematic risk is negatively related to loan spreads, controlling for firm, loan and bank specific va

  20. Forensic Evidence Identification and Modeling for Attacks against a Simulated Online Business Information System

    Directory of Open Access Journals (Sweden)

    Manghui Tu

    2012-12-01

    Full Text Available Forensic readiness can support future forensics investigation or auditing on external/internal attacks, internal sabotage and espionage, and business frauds. To establish forensics readiness, it is essential for an organization to identify what evidences are relevant and where they can be found, to determine whether they are logged in a forensic sound way and whether all the needed evidences are available to reconstruct the events successfully.  Our goal of this research is to ensure evidence availability. First, both external and internal attacks are molded as augmented attack trees/graphs based on the system vulnerabilities. Second, modeled attacks are conducted against a honeynet simulating an online business information system, and each honeypot's hard drive is forensic sound imaged for each individual attack. Third, an evidence tree/graph will be built after forensics examination on the disk images for each attack. The evidence trees/graphs are expected to be used for automatic crime scene reconstruction and automatic attack/fraud detection in the future.

  1. Evidences of a threshold system as the source for magnetic storms detected on Earth s surface

    CERN Document Server

    Papa, A R R; Seixas, N A B; Papa, Andres R. R.; Barreto, Luiz M.; Seixas, Ney A. B.

    2005-01-01

    Threshold systems appear to underlie the global behaviour of physical phenomena very unlike at a first look. The usual experimental fingerprint of threshold system grounded phenomena is the presence of power laws. Experimental evidence has been found, for example, in superconductor vortex avalanches, sand piles, the brain, 4He superfluidity and earthquakes. Double power-laws have been found in social networks, in the luminosity of some galactic nuclei and, very recently, in solar flares, among others. Here we show evidences that point to a threshold system as the source for magnetic storms detected on the Earth. We based our analysis on series of data acquired during many years in the network of magnetic observatories of the National Observatory (Brazil). In particular we focused our attention on October 2000 month of the Vassouras Observatory (RJ, Brazil), which have been active since 1915. We have found both power laws and double power laws for some relevant distributions.

  2. Surveillance, response systems, and evidence updates on emerging zoonoses: the role of one health

    Directory of Open Access Journals (Sweden)

    G. V. Asokan

    2013-12-01

    Full Text Available Globally, emerging zoonotic diseases are increasing. Existing surveillance systems for zoonoses have substantial gaps, especially in developing countries, and the systems in place in the developed world require improvements. Resources and updates on evidence-based practice (EBP for zoonoses are sparser in the veterinary literature as compared to the medical literature. Evidence updates for emerging zoonoses are either absent or rudimentary in both human and veterinary medicine. A ‘one-health’ concept, including a global signaling surveillance system for emerging zoonoses, will be essential for correct diagnoses, interventions, and public health strategies. An open access EBP platform supported by builders of EBP resources is urgently needed to counter emerging zoonoses.

  3. Asthma and obesity in children: current evidence and potential systems biology approaches.

    Science.gov (United States)

    Frey, U; Latzin, P; Usemann, J; Maccora, J; Zumsteg, U; Kriemler, S

    2015-01-01

    Both obesity and asthma are highly prevalent, complex diseases modified by multiple factors. Genetic, developmental, lung mechanical, immunological and behavioural factors have all been suggested as playing a causal role between the two entities; however, their complex mechanistic interactions are still poorly understood and evidence of causality in children remains scant. Equally lacking is evidence of effective treatment strategies, despite the fact that imbalances at vulnerable phases in childhood can impact long-term health. This review is targeted at both clinicians frequently faced with the dilemma of how to investigate and treat the obese asthmatic child and researchers interested in the topic. Highlighting the breadth of the spectrum of factors involved, this review collates evidence regarding the investigation and treatment of asthma in obese children, particularly in comparison with current approaches in 'difficult-to-treat' childhood asthma. Finally, the authors propose hypotheses for future research from a systems-based perspective.

  4. Relevance of the Glutathione System in Temporal Lobe Epilepsy: Evidence in Human and Experimental Models

    Directory of Open Access Journals (Sweden)

    Noemí Cárdenas-Rodríguez

    2014-01-01

    Full Text Available Oxidative stress, which is a state of imbalance in the production of reactive oxygen species and nitrogen, is induced by a wide variety of factors. This biochemical state is associated with diseases that are systemic as well as diseases that affect the central nervous system. Epilepsy is a chronic neurological disorder, and temporal lobe epilepsy represents an estimated 40% of all epilepsy cases. Currently, evidence from human and experimental models supports the involvement of oxidative stress during seizures and in the epileptogenesis process. Hence, the aim of this review was to provide information that facilitates the processing of this evidence and investigate the therapeutic impact of the biochemical status for this specific pathology.

  5. Relevance of the Glutathione System in Temporal Lobe Epilepsy: Evidence in Human and Experimental Models

    Science.gov (United States)

    Cárdenas-Rodríguez, Noemí; Coballase-Urrutia, Elvia; Pérez-Cruz, Claudia; Montesinos-Correa, Hortencia; Rivera-Espinosa, Liliana; Sampieri, Aristides; Carmona-Aparicio, Liliana

    2014-01-01

    Oxidative stress, which is a state of imbalance in the production of reactive oxygen species and nitrogen, is induced by a wide variety of factors. This biochemical state is associated with diseases that are systemic as well as diseases that affect the central nervous system. Epilepsy is a chronic neurological disorder, and temporal lobe epilepsy represents an estimated 40% of all epilepsy cases. Currently, evidence from human and experimental models supports the involvement of oxidative stress during seizures and in the epileptogenesis process. Hence, the aim of this review was to provide information that facilitates the processing of this evidence and investigate the therapeutic impact of the biochemical status for this specific pathology. PMID:25538816

  6. Effects of System Characteristics on Adopting Web-Based Advanced Traveller Information System: Evidence from Taiwan

    Directory of Open Access Journals (Sweden)

    Ting-Wei Lin

    2014-02-01

    Full Text Available This study proposes a behavioural intention model that integrates information quality, response time, and system accessibility into the original technology acceptance model (TAM to investigate whether system characteristics affect the adoption of Web-based advanced traveller information systems (ATIS. This study empirically tests the proposed model using data collected from an online survey of Web-based advanced traveller information system users. Con­firmatory factor analysis (CFA was performed to examine the reliability and validity of the measurement model, and structural equation modelling (SEM was used to evaluate the structural model. The results indicate that three system characteristics had indirect effects on the intention to use through perceived usefulness, perceived ease of use, and attitude toward using. Information quality was the most im­portant system characteristic factor, followed by response time and system accessibility. This study presents implica­tions for practitioners and researchers, and suggests direc­tions for future research.

  7. Hierarchical Evidence Accumulation in the Pseiki System and Experiments in Model-Driven Mobile Robot Navigation

    OpenAIRE

    2013-01-01

    In this paper, we will review the process of evidence accumulation in the PSEIKI system for expectation-driven interpretation of images of 3-D scenes. Expectations are presented to PSEIKI as a geometrical hierarchy of abstractions. PSEIKI's job is then to construct abstraction hierarchies in the perceived image taking cues from the abstraction hierarchies in the expectations. The Dempster-Shafer formalism is used for associating belief values with the different possible labels for the constru...

  8. Application of Evidence-based Medicine and Systems Biology Mediated by Translational Medicine in TCM Study

    Institute of Scientific and Technical Information of China (English)

    Gong Xiangwen; Zhang Jinwen; Yang Qinhe; Yan Haizhen; Zhang Yupei; Liu Yizhen; Xu Yongjian; Wang Hong; Lin Chunmei

    2013-01-01

    The core of translational medicine means that the effective relationship between science researchers of basic medicine and clinical doctors makes basic medicine research transform into diagnosis, prevention and treatment of diseases to compensate for the wide gap between basic and clinical application. Translational medicine was introduced into traditional Chinese medicine (TCM) study, and evidence-based medicine capable of improving the accuracy and reliability of TCM clinical research transforming into basic research and systems biology capable of enhancing the systematicness and integrality of basic research to make it transform into clinical application better were as major technical support, hence, the application of evidence-based medicine and systems biology mediated by translational medicine in TCM will have far-reaching signiifcance for the development of TCM modernization. In this article, the application of evidence-based medicine and systems biology mediated by translational medicine in TCM study is illustrated in terms of TCM in the prevention and treatment of non-alcoholic fatty liver disease (NAFLD) and its clinical and basic bidirectional transformation, literature mining, translational medicine platform and team building.

  9. Developing and refining the methods for a ‘one-stop shop’ for research evidence about health systems

    OpenAIRE

    Lavis, John N.; Wilson, Michael G; Moat, Kaelan A; Hammill, Amanda C; Boyko, Jennifer A; Grimshaw, Jeremy M; Flottorp, Signe

    2015-01-01

    Background: Policymakers, stakeholders and researchers have not been able to find research evidence about health systems using an easily understood taxonomy of topics, know when they have conducted a comprehensive search of the many types of research evidence relevant to them, or rapidly identify decision-relevant information in their search results. Methods: To address these gaps, we developed an approach to building a ‘one-stop shop’ for research evidence about health systems. We developed ...

  10. Evidence against a single coordinate system representation in the motor cortex.

    Science.gov (United States)

    Wu, Wei; Hatsopoulos, Nicholas

    2006-11-01

    Understanding the coordinate systems in which the motor cortical cells encode movement parameters such as direction is a fundamental yet unresolved issue. Although many studies have assumed that motor cortex encodes direction in an extrinsic, Cartesian (CA) coordinate system, other studies have provided evidence for encoding in intermediate coordinate systems such as a shoulder-centered (SC) or in a purely intrinsic, joint-angle-based (JA) coordinate frame. By simultaneously recording from multiple single units in primary motor cortex, we examined movement direction encoding under each of these three coordinate systems. We directly compared the degree of directional tuning invariance over multiple sub-regions in the workspace. We also compared the mutual information between neuronal firing rate and movement direction in the three systems. We observed a broad range of directional invariance in all three coordinate systems with no strong dominance of any single coordinate system. The mutual information analyses corroborated this observation. However, we found a small but significant bias toward the SC coordinate frame, which was also supported by population vector decoding. Similar results were found when we compared hand/torque force direction encoding in all three coordinate systems. These results suggest that the motor cortex employs a coordinate system that is yet to be discovered or perhaps that the motor cortex should not be viewed as a substrate for any coordinate system representation.

  11. Implementing the evidence for language-appropriate health care systems: The Welsh context.

    Science.gov (United States)

    Roberts, Gwerfyl W; Burton, Christopher R

    2013-04-05

    Like Canada, Wales, UK is a bilingual nation: the Welsh language is an important part of its national identity and legislative framework. This has implications for the delivery of public sector services, particularly in the context of health and social care, where responding to the language needs of service users is fundamental to quality health care provision. Nevertheless, despite the strengthening policy commitment for a whole-system approach towards enhancing Welsh language services, there is a paucity of evidence to guide best practice in organizational planning in health care settings. This commentary outlines the context and significance of bilingual health care provision in Wales and the implications for building and embedding the evidence base. It calls for further work to translate our knowledge and understanding of language-appropriate practice to provide more effective and sensitive health care services; and to close the implementation gap between evidence and practice. Given the relevance of this challenge for health care providers in Canada who plan and deliver services for French-language minorities, this approach has resonance across our research communities. Thus, in our common pursuit to establish integrated knowledge translation research for language-appropriate health care systems, this commentary offers a focus for reflection, discussion and collaborative action.

  12. The role of the endocannabinoid system in eating disorders: neurochemical and behavioural preclinical evidence.

    Science.gov (United States)

    Scherma, Maria; Fattore, Liana; Castelli, Maria Paola; Fratta, Walter; Fadda, Paola

    2014-01-01

    The endocannabinoid system has long been known as a modulator of several physiological functions, among which the homeostatic and hedonic aspects of eating. CB1 receptors are widely expressed in brain regions that control food intake, reward and energy balance. Animal and human studies indicate that CB1 receptor agonists possess orexigenic effects enhancing appetite and increasing the rewarding value of food. Conversely, CB1 antagonists have been shown to inhibit the intake of food. Eating disorders include a range of chronic and disabling related pathological illnesses that are characterized by aberrant patterns of feeding behaviour and weight regulation, and by abnormal attitudes and perceptions toward body shape image. The psychological and biological factors underlying eating disorders are complex and not yet completely understood. However in the last decades, converging evidence have led to hypothesise a link between defects in the endocannabinoid system and eating disorders, including obesity. Here we review the neurochemical and behavioural preclinical evidence supporting the role of the endocannabinoid system in eating disorders to offer the reader an update regarding the state of the art. Despite the recent withdrawal from the market of rimonabant for treating obesity and overweight individuals with metabolic complications due to its psychiatric side effects, preclinical findings support the rationale for the clinical development of drug which modulate the endocannabinoid system in the treatment of eating disorders.

  13. Areca nut chewing and systemic inflammation: evidence of a common pathway for systemic diseases

    Directory of Open Access Journals (Sweden)

    Shafique Kashif

    2012-06-01

    Full Text Available Abstract Background Areca nut, the seed of fruit of an oriental palm, known as Areca catechu, is commonly chewed in many countries. Diabetes, hypertension, cardiovascular diseases, oropharyngeal and oesophageal cancers have been associated with areca nut chewing and the mechanism by which areca nut chewing increases the risk of systemic diseases remains elusive. We hypothesize that systemic inflammation may be elevated among areca nut users, which is linked with many systemic diseases. Therefore, this present study was conducted to examine the systemic inflammation among areca nut chewers and healthy controls. Methods This was an observational cross sectional study carried out on areca nut chewers and healthy individuals in Karachi, Pakistan. Participants were selected from a region of the city by invitation request sent from door to door. Information was collected regarding the socio-demographic profile and the pattern of use, and a blood sample was obtained to measure the level of C-reactive protein (CRP. We carried out multiple logistic regressions to investigate the association between socio-demographic profile, areca nut chewing and CRP levels. Results We carried out final analysis on 1112 individuals of which 556 were areca nut chewers and 556 were the age, gender and area matched controls. Areca nut chewers had a significantly higher proportion of men (15.1%, n = 84 who had an elevated CRP (>10 mg/dl as compared to controls (5.2%, n = 29. Multivariate analyses showed that areca nut chewers had significantly higher odds of an elevated CRP (OR = 3.23, 95% CI 2.08-5.02, p value Conclusions Areca nut chewing has a significant association with systemic inflammation. Further work is required to confirm that systemic inflammation is the main pathway by which areca nut use increases the risk of systemic diseases.

  14. An examination of cross-cultural systems implementing evidence-based assessment and intervention approaches

    Directory of Open Access Journals (Sweden)

    Murray Laura K

    2006-01-01

    Full Text Available Implementation of evidence-based assessment and intervention approaches for youth with behavioral and/or emotional problems is rising to recognition worldwide. Feasibility research is critical to examine what characteristics of systems allow for success or barriers to the implementation of evidence-based practices into real-world settings, especially when working cross-culturally. This paper briefly reviews the experience of 4 international sites to understand how the overall structure and specific site variables directed the implementation of the World Health Organization and the World Psychiatry Association project. Discussion includes a thematic summary of the successes and challenges experienced by the sites, and future directions of feasibility studies.

  15. Motivating medical information system performance by system quality, service quality, and job satisfaction for evidence-based practice

    Science.gov (United States)

    2012-01-01

    Background No previous studies have addressed the integrated relationships among system quality, service quality, job satisfaction, and system performance; this study attempts to bridge such a gap with evidence-based practice study. Methods The convenience sampling method was applied to the information system users of three hospitals in southern Taiwan. A total of 500 copies of questionnaires were distributed, and 283 returned copies were valid, suggesting a valid response rate of 56.6%. SPSS 17.0 and AMOS 17.0 (structural equation modeling) statistical software packages were used for data analysis and processing. Results The findings are as follows: System quality has a positive influence on service quality (γ11= 0.55), job satisfaction (γ21= 0.32), and system performance (γ31= 0.47). Service quality (β31= 0.38) and job satisfaction (β32= 0.46) will positively influence system performance. Conclusions It is thus recommended that the information office of hospitals and developers take enhancement of service quality and user satisfaction into consideration in addition to placing b on system quality and information quality when designing, developing, or purchasing an information system, in order to improve benefits and gain more achievements generated by hospital information systems. PMID:23171394

  16. Moving science into state child and adolescent mental health systems: Illinois' evidence-informed practice initiative.

    Science.gov (United States)

    Starin, Amy C; Atkins, Marc S; Wehrmann, Kathryn C; Mehta, Tara; Hesson-McInnis, Matthew S; Marinez-Lora, A; Mehlinger, Renee

    2014-01-01

    In 2005, the Illinois State Mental Health Authority embarked on an initiative to close the gap between research and practice in the children's mental health system. A stakeholder advisory council developed a plan to advance evidence informed practice through policy and program initiatives. A multilevel approach was developed to achieve this objective, which included policy change, stakeholder education, and clinician training. This article focuses on the evidence-informed training process designed following review of implementation research. The training involved in-person didactic sessions and twice-monthly telephone supervision across 6 cohorts of community based clinicians, each receiving 12 months of training. Training content initially included cognitive behavioral therapy and behavioral parent training and was adapted over the years to a practice model based on common element concepts. Evaluation based on provider and parent report indicated children treated by training clinicians generally showed superior outcomes versus both a treatment-as-usual comparison group for Cohorts 1 to 4 and the statewide child population as a whole after 90 days of care for Cohorts 5 to 6. The results indicated primarily moderate to strong effects for the evidence-based training groups. Moving a large public statewide child mental health system toward more effective services is a complex and lengthy process. These results indicate training of community mental health providers in Illinois in evidence-informed practice was moderately successful in positively impacting child-level functional outcomes. These findings also influenced state policy in committing resources to continuing the initiative, even in difficult economic times.

  17. Complementary roles of systems representing sensory evidence and systems detecting task difficulty during perceptual decision making

    Directory of Open Access Journals (Sweden)

    Douglas A Ruff

    2010-11-01

    Full Text Available Perceptual decision making is a multi-stage process where incoming sensory information is used to select one option from several alternatives. Researchers typically have adopted one of two conceptual frameworks to define the criteria for determining whether a brain region is involved in decision computations. One framework, building on single unite recordings in monkeys, posits that activity in a region involved in decision making reflects the accumulation of evidence toward a decision threshold, thus showing the lowest level of BOLD signal during the hardest decisions. The other framework instead posits that activity in a decision-making region reflects the difficulty of a decision, thus showing the highest level of BOLD signal during the hardest decisions. We had subjects perform a face detection task on degraded face images while we simultaneously recorded BOLD activity. We searched for brain regions where changes in BOLD activity during this task supported either of these frameworks by calculating the correlation of BOLD activity with reaction time - a measure of task difficulty. We found that the right supplementary eye field, right frontal eye field and right inferior frontal gyrus had increased activity relative to baseline that positively correlated with reaction time, while the left superior frontal sulcus and left middle temporal gyrus had decreased activity relative to baseline that negatively correlated with reaction time. We propose that a simple mechanism that scales a region’s activity based on task demands can explain our results.

  18. Do Capitation-based Reimbursement Systems Underfund Tertiary Healthcare Providers? Evidence from New Zealand.

    Science.gov (United States)

    Shin, Somi; Schumacher, Christoph; Feess, Eberhard

    2017-02-01

    One of the main concerns about capitation-based reimbursement systems is that tertiary institutions may be underfunded due to insufficient reimbursements of more complicated cases. We test this hypothesis with a data set from New Zealand that, in 2003, introduced a capitation system where public healthcare provider funding is primarily based on the characteristics of the regional population. Investigating the funding for all cases from 2003 to 2011, we find evidence that tertiary providers are at a disadvantage compared with secondary providers. The reasons are that tertiary providers not only attract the most complicated, but also the highest number of cases. Our findings suggest that accurate risk adjustment is crucial to the success of a capitation-based reimbursement system. Copyright © 2017 John Wiley & Sons, Ltd.

  19. What is the role of health systems in responding to domestic violence? An evidence review.

    Science.gov (United States)

    Spangaro, Jo

    2017-01-20

    Objective The aim of the present study was to review and analyse academic literature and program evaluations to identify promising evidence for health system responses to domestic violence in Australia and internationally.Methods English-language literature published between January 2005 and March 2016 was retrieved from search results using the terms 'domestic violence' or 'intimate partner violence' in different combinations with other relevant terms, resulting in 1671 documents, of which 59 were systematic reviews. Electronic databases (Medline (Ovid), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Psycinfo, Social work Abstracts, Informit, Violence and Abuse Abstracts, Family Studies Abstracts, Cochrane Library of Systematic Reviews and EMBASE) were searched and narrative analysis undertaken.Results This review details the evidence base for the following interventions by health services responding to domestic violence: first-line responses, routine screening, risk assessment and safety planning, counselling with women, mother-child interventions, responses to perpetrators, child protection notifications, training and system-level responses.Conclusions There is growing evidence for the effectiveness of health service interventions to reduce the extent of harm caused by domestic violence.What is known about the topic? Domestic violence is a significant problem globally with enormous human, social and economic costs. Although women who have experienced abuse make extensive use of healthcare services, health services have lagged behind the policing, criminal justice and other human service domains in responding to domestic violence.What does this paper add? The present comprehensive review identifies best-practice health system responses to domestic violence.What are the implications for practitioners? Health systems can play a key role in identifying and responding to domestic violence for women who often do not access other services. There is

  20. Substance abuse interventions for parents involved in the child welfare system: evidence and implications.

    Science.gov (United States)

    Osterling, Kathy Lemon; Austin, Michael J

    2008-01-01

    As child welfare systems across the country face the problem of parental substance abuse, there is an increasing need to understand the types of treatment approaches that are most effective for substance-abusing parents in the child welfare system-the majority of whom are mothers. This structured review of the literature focuses on evidence related to two areas: (1) individual-level interventions designed to assist mothers and women in addressing their substance abuse problems, and (2) system-level interventions designed to improve collaboration and coordination between the child welfare system and the alcohol and other drug system. Overall, research suggests the following program components may be effective with substance-abusing women with children: (1) Women-centered treatment that involves children, (2) Specialized health and mental health services, (3) Home visitation services, (4) Concrete assistance, (5) Short-term targeted interventions, and (6) Comprehensive programs that integrate many of these components. Research also suggests that promising collaborative models between the child welfare system (CWS) and the alcohol and other drug (AOD) system typically include the following core elements: (1) Out-stationing AOD workers in child welfare offices, (2) Joint case planning, (3) Using official committees to guide collaborative efforts, (4) Training and cross-training, (5) Using protocols for sharing confidential information, and (6) Using dependency drug courts. Although more rigorous research is needed on both individual-level and system-level substance abuse interventions for parents involved in the child welfare system, the integration of individual-level interventions and system-level approaches is a potentially useful practice approach with this vulnerable population.

  1. EULAR points to consider for conducting clinical trials in systemic lupus erythematosus : literature based evidence for the selection of endpoints

    NARCIS (Netherlands)

    Bertsias, G. K.; Ioannidis, J. P. A.; Boletis, J.; Bombardieri, S.; Cervera, R.; Dostal, C.; Font, J.; Gilboe, I. M.; Houssiau, F.; Huizinga, T.; Isenberg, D.; Kallenberg, C. G. M.; Khamashta, M.; Piette, J. C.; Schneider, M.; Smolen, J.; Sturfelt, G.; Tincani, A.; van Vollenhoven, R.; Boumpas, D. T.; Gordon, C.

    2009-01-01

    Objective: To assess available evidence on the use of end-points ( outcome measures) in clinical trials in systemic lupus erythematosus (SLE), as a part of the development of evidence-based recommendations for points to consider in clinical trials in SLE. Methods: The European League Against Rheumat

  2. EULAR points to consider for conducting clinical trials in systemic lupus erythematosus: literature based evidence for the selection of endpoints

    NARCIS (Netherlands)

    Bertsias, G.K.; Ioannidis, J.P.A.; Boletis, J.; Bombardieri, S.; Cervera, R.; Dostal, C.; Font, J.; Gilboe, I.M.; Houssiau, F.; Huizinga, T.; Isenberg, D.; Kallenberg, Cees; Khamashta, M.; Piette, J.C.; Schneider, M.; Smolen, J.; Sturfelt, G.; Tincani, A.; Van Vollenhoven, R.; Boumpas, D.T.; Gordon, C.

    2009-01-01

    Objective: To assess available evidence on the use of end-points ( outcome measures) in clinical trials in systemic lupus erythematosus (SLE), as a part of the development of evidence-based recommendations for points to consider in clinical trials in SLE. Methods: The European League Against Rheumat

  3. UCLA, British astronomers discover wake of planet around nearby star. Strong evidence for solar system like ours

    CERN Multimedia

    2002-01-01

    "An international team of astronomers reports the first strong evidence for the existence of massive planets on wide orbits - like those of Saturn, Uranus and Neptune - around many stars. The new research provides some of the strongest evidence so far that solar systems similar to our own, or even larger, are likely to exist: (1 page).

  4. B-Cell Depletion Therapy in Systemic Sclerosis: Experimental Rationale and Update on Clinical Evidence

    Directory of Open Access Journals (Sweden)

    Dimitrios Daoussis

    2011-01-01

    Full Text Available Systemic sclerosis (SSc is a systemic rheumatic disease with poor prognosis since therapeutic options are limited. Recent evidence from animal models suggests that B-cells may be actively involved in the fibrotic process. B-cells from tight skin mice, an animal model of scleroderma, display a “hyperresponsive” phenotype; treatment with rituximab (RTX significantly attenuates skin fibrosis in this animal model. In humans, B-cell infiltration is a prominent finding in most lung biopsies obtained from patients with SSc-associated interstitial lung disease. Several open label studies have assessed the clinical efficacy of RTX in SSc. In most patients skin fibrosis improved; lung function either improved or remained stable. Definite conclusions regarding the clinical efficacy of RTX in SSc cannot be drawn but further exploration with a multicenter, randomized study is warranted.

  5. Isotopic evidence of magmatism and a sedimentary carbon source at the Endeavour hydrothermal system

    Energy Technology Data Exchange (ETDEWEB)

    Brown, T A; Proskurowski, G; Lilley, M D

    2004-01-07

    Stable and radiocarbon isotope measurements made on CO{sub 2} from high temperature hydrothermal vents on the Endeavour Segment of the Juan de Fuca Ridge indicate both magmatic and sedimentary sources of carbon to the hydrothermal system. The Endeavour segment is devoid of overlying sediments and has shown no observable signs of surficial magmatic activity during the {approx}20 years of ongoing studies. The appearance of isotopically heavy, radiocarbon dead CO{sub 2} after a 1999 earthquake swarm requires that this earthquake event was magmatic in origin. Evidence for a sedimentary organic carbon source suggests the presence of buried sediments at the ridge axis. These findings, which represent the first temporally coherent set of radiocarbon measurements from hydrothermal vent fluids, demonstrate the utility of radiocarbon analysis in hydrothermal studies. The existence of a sediment source at Endeavour and the occurrence of magmatic episodes illustrate the extremely complex and evolving nature of the Endeavour hydrothermal system.

  6. Scaling up evidence-based practices for children and families in New York State: toward evidence-based policies on implementation for state mental health systems.

    Science.gov (United States)

    Hoagwood, Kimberly Eaton; Olin, S Serene; Horwitz, Sarah; McKay, Mary; Cleek, Andrew; Gleacher, Alissa; Lewandowski, Eric; Nadeem, Erum; Acri, Mary; Chor, Ka Ho Brian; Kuppinger, Anne; Burton, Geraldine; Weiss, Dara; Frank, Samantha; Finnerty, Molly; Bradbury, Donna M; Woodlock, Kristin M; Hogan, Michael

    2014-01-01

    Dissemination of innovations is widely considered the sine qua non for system improvement. At least two dozen states are rolling out evidence-based mental health practices targeted at children and families using trainings, consultations, webinars, and learning collaboratives to improve quality and outcomes. In New York State (NYS) a group of researchers, policymakers, providers, and family support specialists have worked in partnership since 2002 to redesign and evaluate the children's mental health system. Five system strategies driven by empirically based practices and organized within a state-supported infrastructure have been used in the child and family service system with more than 2,000 providers: (a) business practices, (b) use of health information technologies in quality improvement, (c) specific clinical interventions targeted at common childhood disorders, (d) parent activation, and (e) quality indicator development. The NYS system has provided a laboratory for naturalistic experiments. We describe these initiatives, key findings and challenges, lessons learned for scaling, and implications for creating evidence-based implementation policies in state systems.

  7. Evidence evaluation in fingerprint comparison and automated fingerprint identification systems--modelling within finger variability.

    Science.gov (United States)

    Egli, Nicole M; Champod, Christophe; Margot, Pierre

    2007-04-11

    Recent challenges and errors in fingerprint identification have highlighted the need for assessing the information content of a papillary pattern in a systematic way. In particular, estimation of the statistical uncertainty associated with this type of evidence is more and more called upon. The approach used in the present study is based on the assessment of likelihood ratios (LRs). This evaluative tool weighs the likelihood of evidence given two mutually exclusive hypotheses. The computation of likelihood ratios on a database of marks of known sources (matching the unknown and non-matching the unknown mark) allows an estimation of the evidential contribution of fingerprint evidence. LRs are computed taking advantage of the scores obtained from an automated fingerprint identification system and hence are based exclusively on level II features (minutiae). The AFIS system attributes a score to any comparison (fingerprint to fingerprint, mark to mark and mark to fingerprint), used here as a proximity measure between the respective arrangements of minutiae. The numerator of the LR addresses the within finger variability and is obtained by comparing the same configurations of minutiae coming from the same source. Only comparisons where the same minutiae are visible both on the mark and on the print are therefore taken into account. The denominator of the LR is obtained by cross-comparison with a database of prints originating from non-matching sources. The estimation of the numerator of the LR is much more complex in terms of specific data requirements than the estimation of the denominator of the LR (that requires only a large database of prints from an non-associated population). Hence this paper addresses specific issues associated with the numerator or within finger variability. This study aims at answering the following questions: (1) how a database for modelling within finger variability should be acquired; (2) whether or not the visualisation technique or the

  8. Cosmochemical evidence for astrophysical processes during the formation of our solar system.

    Science.gov (United States)

    MacPherson, Glenn J; Boss, Alan

    2011-11-29

    Through the laboratory study of ancient solar system materials such as meteorites and comet dust, we can recognize evidence for the same star-formation processes in our own solar system as those that we can observe now through telescopes in nearby star-forming regions. High temperature grains formed in the innermost region of the solar system ended up much farther out in the solar system, not only the asteroid belt but even in the comet accretion region, suggesting a huge and efficient process of mass transport. Bi-polar outflows, turbulent diffusion, and marginal gravitational instability are the likely mechanisms for this transport. The presence of short-lived radionuclides in the early solar system, especially (60)Fe, (26)Al, and (41)Ca, requires a nearby supernova shortly before our solar system was formed, suggesting that the Sun was formed in a massive star-forming region similar to Orion or Carina. Solar system formation may have been "triggered" by ionizing radiation originating from massive O and B stars at the center of an expanding HII bubble, one of which may have later provided the supernova source for the short-lived radionuclides. Alternatively, a supernova shock wave may have simultaneously triggered the collapse and injected the short-lived radionuclides. Because the Sun formed in a region where many other stars were forming more or less contemporaneously, the bi-polar outflows from all such stars enriched the local region in interstellar silicate and oxide dust. This may explain several observed anomalies in the meteorite record: a near absence of detectable (no extreme isotopic properties) presolar silicate grains and a dichotomy in the isotope record between (26)Al and nucleosynthetic (nonradiogenic) anomalies.

  9. Essential evidence for guiding health system priorities and policies: anticipating epidemiological transition in Africa

    Directory of Open Access Journals (Sweden)

    Peter Byass

    2014-05-01

    Full Text Available Background: Despite indications that infection-related mortality in sub-Saharan Africa may be decreasing and the burden of non-communicable diseases increasing, the overwhelming reality is that health information systems across most of sub-Saharan Africa remain too weak to track epidemiological transition in a meaningful and effective way. Proposals: We propose a minimum dataset as the basis of a functional health information system in countries where health information is lacking. This would involve continuous monitoring of cause-specific mortality through routine civil registration, regular documentation of exposure to leading risk factors, and monitoring effective coverage of key preventive and curative interventions in the health sector. Consideration must be given as to how these minimum data requirements can be effectively integrated within national health information systems, what methods and tools are needed, and ensuring that ethical and political issues are addressed. A more strategic approach to health information systems in sub-Saharan African countries, along these lines, is essential if epidemiological changes are to be tracked effectively for the benefit of local health planners and policy makers. Conclusion: African countries have a unique opportunity to capitalize on modern information and communications technology in order to achieve this. Methodological standards need to be established and political momentum fostered so that the African continent's health status can be reliably tracked. This will greatly strengthen the evidence base for health policies and facilitate the effective delivery of services.

  10. Molecular evidence for ongoing complementarity and horizontal gene transfer in endosymbiotic systems of mealybugs

    Directory of Open Access Journals (Sweden)

    Sergio eLópez-Madrigal

    2014-08-01

    Full Text Available Intracellular bacterial supply of essential amino acids is common among sap-feeding insects, thus complementing the scarcity of nitrogenous compounds in plant phloem. This is also the role of the two mealybug endosymbiotic systems whose genomes have been sequenced. In the nested endosymbiotic system from Planococcus citri (Pseudococcinae, Candidatus Tremblaya princeps and Candidatus Moranella endobia cooperate to synthesize essential amino acids, while in Phenacoccus avenae (Phenacoccinae this function is performed by its single endosymbiont Candidatus Tremblaya phenacola. However, little is known regarding the evolution of essential amino acid supplementation strategies in other mealybug systems. To address this knowledge gap, we screened for the presence of six selected loci involved in essential amino acid biosynthesis in five additional mealybug species. We found evidence of ongoing complementarity among endosymbionts from insects of subfamily Pseudococcinae, as well as horizontal gene transfer affecting endosymbionts from insects of family Phenacoccinae, providing a more comprehensive picture of the evolutionary history of these endosymbiotic systems. Additionally, we report two diagnostic motifs to help identify invasive mealybug species.

  11. Memory labilization in reconsolidation and extinction--evidence for a common plasticity system?

    Science.gov (United States)

    Almeida-Corrêa, Suellen; Amaral, Olavo B

    2014-01-01

    Reconsolidation and extinction are two processes occurring upon memory retrieval that have received great attention in memory research over the last decade, partly due to their purported potential in the treatment of anxiety disorders. Due to their opposite behavioral effects, the two phenomena have usually been considered as separate entities, with few attempts to build a unified view of how both could be produced by similar mechanisms. Based on computational modeling, we have previously proposed that reconsolidation and extinction are behavioral outcomes of the same set of plasticity systems, albeit working at different synapses. One of these systems seems to be pharmacologically similar to the one involved in initial memory consolidation, and likely involves traditional Hebbian plasticity, while the second seems to be more involved with the labilization of existing memories and/or synaptic changes. In this article, we review the evidence for the existence of a plasticity system specifically involved in memory labilization, as well as its possible molecular requirements, anatomical substrates, synaptic mechanisms and physiological roles. Based on these data, we propose that the field of memory updating might ultimately benefit from a paradigm shift in which reconsolidation and extinction are viewed not as separate processes but as different instantiations of plasticity systems responsible for reinforcement and labilization of synaptic changes.

  12. The Impact of Three Evidence-Based Programmes Delivered in Public Systems in Birmingham, UK

    Directory of Open Access Journals (Sweden)

    Michael Little

    2012-12-01

    Full Text Available The Birmingham Brighter Futures strategy was informed by epidemiological data on child well-being and evidence on “what works,” and included the implementation and evaluation of three evidence-based programmes in regular children’s services systems, as well as an integrated prospective cost-effectiveness analysis (reported elsewhere. A randomised controlled trial (RCT of the Incredible Years BASIC parenting programme involved 161 children aged three and four at risk of a social-emotional or behavioural disorder. An RCT of the universal PATHS social-emotional learning curriculum involved children aged four–six years in 56 primary schools. An RCT of the Level 4 Group Triple-P parenting programme involved parents of 146 children aged four–nine years with potential social-emotional or behavioural disorders. All three studies used validated standardised measures. Both parenting programme trials used parentcompletedmeasures of child and parenting behaviour. The school-based trial used teacher reports of children’s behaviour, emotions, and social competence.Incredible Years yielded reductions in negative parenting behaviours among parents, reductions in child behaviour problems, and improvements in children’s relationships. In the PATHS trial, modest improvements in emotional health and behavioural development after one year disappeared by the end of year two. There were no effects for Triple-P. Much can be learned from the strengths and limitations of the Birmingham experience.

  13. Assessment and improvement of the Italian healthcare system: first evidence from a pilot national performance evaluation system.

    Science.gov (United States)

    Nuti, Sabina; Seghieri, Chiara; Vainieri, Milena; Zett, Silvia

    2012-01-01

    The Italian National Health System (NHS), established in 1978, follows a model similar to the Beveridge model developed by the British NHS (Beveridge 1942; Musgrove 2000). Like the British NHS, healthcare coverage for the Italian population is provided and financed by the government through taxes. Universal coverage provides uniform healthcare access to citizens and is the characteristic usually considered the added value of a welfare system financed by tax revenues. Nonetheless, in Italy the strong policy of decentralization, which has been taking place since the early 1990s, has gradually shifted powers from the state to the 21 Italian regions. Consequently, the state now retains limited supervisory control and continues to have overall responsibility for the NHS in order to ensure uniform and essential levels of health services across the country. In this context, it has become essential, both for the ministry and for regions, to adopt a common performance evaluation system (PES). This article reports the definition, implementation, and first evidences of a pilot PES at a national level. It shows how this PES can be viewed as a strategic tool supporting the Ministry of Health (MoH) in ensuring uniform levels of care for the population and assisting regional managers to evaluate performance in benchmarking. Finally, lessons for other health systems, based on the Italian experience, are provided.

  14. Management earnings forecasts and analyst forecasts:Evidence from mandatory disclosure system

    Institute of Scientific and Technical Information of China (English)

    Yutao; Wang; Yunsen; Chen; Juxian; Wang

    2015-01-01

    Distinct from the literature on the effects that management earnings forecasts(MEFs) properties, such as point, range and qualitative estimations, have on analyst forecasts, this study explores the effects of selective disclosure of MEFs.Under China’s mandatory disclosure system, this study proposes that managers issue frequent forecasts to take advantage of opportune changes in predicted earnings. The argument herein is that this selective disclosure of MEFs increases information asymmetry and uncertainty, negatively influencing analyst earnings forecasts. Empirical evidence shows that firms that issue more frequent forecasts and make significant changes in MEFs are less likely to attract an analyst following, which can lead to less accurate analyst forecasts. The results imply that the selective disclosure of MEFs damages information transmission and market efficiency, which can enlighten regulators seeking to further enhance disclosure policies.

  15. Evidence for a spatially extensive hydrothermal system at the Ries impact structure, Germany

    Science.gov (United States)

    Sapers, H. M.; Osinski, G. R.; Flemming, R. L.; Buitenhuis, E.; Banerjee, N. R.; Tornabene, L. L.; Blain, S.; Hainge, J.

    2017-02-01

    The 15 Ma, 26 km diameter Ries impact structure in south-central Germany was one of the first terrestrial impact structures where evidence of impact-associated hydrothermal alteration was recognized. Previous studies suggested that pervasive, high-temperature hydrothermal activity was restricted to the area within the "inner ring" (i.e., the crater-fill impactite units). Here we present mineralogical evidence for localized hydrothermal activity in the ejecta beyond the crater rim in two previously unstudied settings: a pervasively altered lens of suevite ejecta directly overlying the Bunte Breccia at the Aumühle quarry; and suevite ejecta at depth overlain by 20 m of lacustrine sediments sampled by the Wörnitzostheim 1965 drill core. A comprehensive set of X-ray diffraction analyses indicates five distinct alteration regimes (1) surficial ambient weathering characterized by smectite and a minor illitic component; (2) locally restricted hydrothermal activity characterized by an illitic component and minor smectite; (3) hydrothermal activity at depth characterized by smectite, a minor illitic component, and calcite; (4) hydrothermal activity at depth characterized by smectite, a minor illitic component, calcite, zeolites, and clinochlore; and (5) pervasive hydrothermal activity at depth characterized by smectite, a minor illitic component, and minor clinochlore. These data spatially extend the Ries postimpact hydrothermal system suggesting a much more extensive, complex, and dynamic system than previously thought. Constraining the mineralogical alteration regimes at the Ries impact structure may also further our understanding of impact-associated phyllosilicate formation on Mars with implications for climate models and habitability.

  16. A MACROPRUDENTIAL SUPERVISION MODEL. EMPIRICAL EVIDENCE FROM THE CENTRAL AND EASTERN EUROPEAN BANKING SYSTEM

    Directory of Open Access Journals (Sweden)

    Trenca Ioan

    2013-07-01

    Full Text Available One of the positive effects of the financial crises is the increasing concern of the supervisors regarding the financial system’s stability. There is a need to strengthen the links between different financial components of the financial system and the macroeconomic environment. Banking systems that have an adequate capitalization and liquidity level may face easier economic and financial shocks. The purpose of this empirical study is to identify the main determinants of the banking system’s stability and soundness in the Central and Eastern Europe countries. We asses the impact of different macroeconomic variables on the quality of capital and liquidity conditions and examine the behaviour of these financial stability indicators, by analyzing a sample of 10 banking systems during 2000-2011. The availability of banking capital signals the banking system’s resiliency to shocks. Capital adequacy ratio is the main indicator used to assess the banking fragility. One of the causes of the 2008-2009 financial crisis was the lack of liquidity in the banking system which led to the collapse of several banking institutions and macroeconomic imbalances. Given the importance of liquidity for the banking system, we propose several models in order to determine the macroeconomic variables that have a significant influence on the liquid reserves to total assets ratio. We found evidence that GDP growth, inflation, domestic credit to private sector, as well as the money and quasi money aggregate indicator have significant impact on the banking stability. The empirical regression confirms the high level of interdependence of the real sector with the financial-banking sector. Also, they prove the necessity for an effective macro prudential supervision at country level which enables the supervisory authorities to have an adequate control over the macro prudential indicators and to take appropriate decisions at the right time.

  17. Evidence for a dysregulated immune system in the etiology of psychiatric disorders.

    Science.gov (United States)

    Gibney, Sinead M; Drexhage, Hemmo A

    2013-09-01

    There is extensive bi-directional communication between the brain and the immune system in both health and disease. In recent years, the role of an altered immune system in the etiology of major psychiatric disorders has become more apparent. Studies have demonstrated that some patients with major psychiatric disorders exhibit characteristic signs of immune dysregulation and that this may be a common pathophysiological mechanism that underlies the development and progression of these disorders. Furthermore, many psychiatric disorders are also often accompanied by chronic medical conditions related to immune dysfunction such as autoimmune diseases, diabetes and atherosclerosis. One of the major psychiatric disorders that has been associated with an altered immune system is schizophrenia, with approximately one third of patients with this disorder showing immunological abnormalities such as an altered cytokine profile in serum and cerebrospinal fluid. An altered cytokine profile is also found in a proportion of patients with major depressive disorder and is thought to be potentially related to the pathophysiology of this disorder. Emerging evidence suggests that altered immune parameters may also be implicated in the neurobiological etiology of autism spectrum disorders. Further support for a role of immune dysregulation in the pathophysiology of these psychiatric disorders comes from studies showing the immunomodulating effects of antipsychotics and antidepressants, and the mood altering effects of anti-inflammatory therapies. This review will not attempt to discuss all of the psychiatric disorders that have been associated with an augmented immune system, but will instead focus on several key disorders where dysregulation of this system has been implicated in their pathophysiology including depression, schizophrenia and autism spectrum disorder.

  18. Evolution of health coverage in Mexico: evidence of progress and challenges in the Mexican health system.

    Science.gov (United States)

    Urquieta-Salomón, José E; Villarreal, Héctor J

    2016-02-01

    To consolidate an effective and efficient universal health care coverage requires a deep understanding of the challenges faced by the health care system in providing services demanded by population in need. This study analyses the dynamics of health insurance coverage and effective access coverage to some health interventions in Mexico. It examines the evolution of inequalities and heterogeneous performance of the insurance subsystems incorporated under the Mexican health care system. Two types of coverage indicators were selected: health insurance and effective access to preventive health interventions intended for normative population. Data were drawn from National Health and Nutrition Surveys 2006 and 2012. The economic inequality was estimated using the Standardized Concentration Index by household per capita consumption expenditure as socioeconomic-status indicator. Approximately 75% of the population reported being covered by one of the existing insurance schemes, representing a huge step forward from 2006, when as much as 51.62% of the population had no health insurance. About 87% of this growth was attributable to the expansion of Non Contributory Health Insurance whereas 7% emanated from the Social Security subsystem. The results revealed that inequality in access to health insurance was virtually eradicated; however, traces of unequal access persisted in some subpopulations groups. Coverage indicators of effective access showed a slight improvement in the period analysed, but prenatal care and interventions to prevent chronic disease still presented a serious shortage. Furthermore, there was no evidence that inequities in coverage of these interventions have decreased in recent years. The results provided a mixed picture, generalizable to the system as a whole, expansion of insurance status represents one of the most remarkable advances that have not been accompanied by a significant improvement in effective access. In addition, existing inequalities are

  19. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

    Science.gov (United States)

    Davis, Mark E.; Zuckerman, Jonathan E.; Choi, Chung Hang J.; Seligson, David; Tolcher, Anthony; Alabi, Christopher A.; Yen, Yun; Heidel, Jeremy D.; Ribas, Antoni

    2010-01-01

    Therapeutics that are designed to engage RNA interference (RNAi) pathways have the potential to provide new, major ways of imparting therapy to patients.1,2 Fire et al. first demonstrated that long, double stranded RNAs mediate RNAi in Caenorhabditis elegans,3 and Elbashir et al. opened the pathway to the use of RNAi for human therapy by showing that small interfering RNAs (siRNAs: ca. 21 base pair double stranded RNA) can elicit RNAi in mammalian cells without producing an interferon response.4 We are currently conducting the first-in-human Phase I clinical trial involving the systemic administration of siRNA to patients with solid cancers using a targeted, nanoparticle delivery system. Here we provide evidence of inducing an RNAi mechanism of action in a human from the delivered siRNA. Tumor biopsies from melanoma patients obtained after treatment reveal: (i) the presence of intracellularly-localized nanoparticles in amounts that correlate with dose levels of the nanoparticles administered (this is a first for systemically delivered nanoparticles of any kind), and (ii) reduction in both the specific mRNA (M2 subunit of ribonucleotide reductase (RRM2)) and the protein (RRM2) when compared to pre-dosing tissue. Most importantly, we detect the presence of an mRNA fragment that demonstrates siRNA mediated mRNA cleavage occurs specifically at the site predicted for an RNAi mechanism from a patient who received the highest dose of the nanoparticles. These data when taken in total demonstrate that siRNA administered systemically to a human can produce a specific gene inhibition (reduction in mRNA and protein) by an RNAi mechanism of action. PMID:20305636

  20. Evidence-based careflow management systems: the case of post-stroke rehabilitation.

    Science.gov (United States)

    Panzarasa, S; Maddè, S; Quaglini, S; Pistarini, C; Stefanelli, M

    2002-04-01

    The activities of a care providers' team need to be coordinated within a process properly designed on the basis of available best practice medical knowledge. It requires a rethinking of the management of care processes within health care organizations. The current workflow technology seems to offer the most convenient solution to build such cooperative systems. However, some of its present weaknesses still require an intense research effort to find solutions allowing its exploitation in real medical practice. This paper presents an approach to design and build evidence-based careflow management systems, which can be viewed as components of a knowledge management infrastructure each health care organization should be provided with to increase its performance in delivering high quality care by efficiently exploiting the available knowledge resources. The post-stroke rehabilitation process has been taken as a challenging care problem to assess our methodology for designing and developing careflow management systems. Then a system was co-developed with a team of rehabilitation professionals who will be committed to use it in their daily work. The system's main goal is to deliver a full array of rehabilitation services provided by an interdisciplinary team. They are related to identify which patients are most likely to benefit from rehabilitation, manage a rehabilitation treatment plan, and monitor progress both during rehabilitation and after return to a community residence. A model of the rehabilitation process was derived from an international guideline and adapted to the local organization of work. It involves different organizational units, such as wards, rehabilitation units, clinical laboratories, and imaging services. Several organizational agents work within them and play one or more roles. Each role is defined by the goals' set that she/he must fulfill. Special effort has been given to the design and development of a knowledge-based system for managing

  1. Observational Evidence for a Dark Side to NGC5128's Globular Cluster System

    CERN Document Server

    Taylor, Matthew; Gomez, Matias; Woodley, Kristin

    2015-01-01

    We present a study of the dynamical properties of 125 compact stellar systems (CSSs) in the nearby giant elliptical galaxy NGC5128, using high-resolution spectra (R 26,000) obtained with VLT/FLAMES. Our results provide evidence for a new type of star cluster, based on the CSS dynamical mass scaling relations. All radial velocity (v_r) and line-of-sight velocity dispersion (sigma_los) measurements are performed with the penalized pixel fitting (ppxf) technique, which provided sigma_ppxf estimates for 115 targets. The sigma_ppxf estimates are corrected to the 2D projected half-light radii, sigma_{1/2}, as well as the cluster cores, sigma_0, accounting for observational/aperture effects and are combined with structural parameters, from high spatial resolution imaging, in order to derive total dynamical masses (M_dyn) for 112 members of NGC5128's star cluster system. In total, 89 CSSs have dynamical masses measured for the first time along with the corresponding dynamical mass-to-light ratios (Upsilon_V^dyn). We ...

  2. A meta-analysis for headache in systemic lupus erythematosus: the evidence and the myth.

    Science.gov (United States)

    Mitsikostas, Dimos D; Sfikakis, Petros P; Goadsby, Peter J

    2004-05-01

    Controversies in the occurrence and implications of headache in patients suffering from systemic lupus erythematosus (SLE) triggered us to conduct an extensive literature search in order to answer five clinical questions. (i) Is headache prevalence higher in SLE patients than in the general population? (ii) Is 'lupus headache' a separate entity? (iii) Is there a distinct pathogenetic mechanism of headache in SLE? (iv) Is headache related to CNS involvement or general SLE activity? (v) Is headache related to anxiety- and depression-like symptoms in SLE? All published articles reporting data from >30 SLE patients were classified into four classes (I, IIa, IIb and III) by the quality of their evidence. We found no prospective controlled study (class I), but we identified seven controlled (class II) and 28 uncontrolled studies (class III) that retrospectively investigated the occurrence of headache in SLE patients. Eight out of 35 studies applied the International Headache Society (IHS) criteria for headache classification, whereas only four uncontrolled studies investigated paediatric SLE populations (class III). Pooled data from eight studies (controlled and uncontrolled) that used the IHS criteria show that 57.1% of SLE patients reported any type of headache (migraine 31.7% and tension-type headache 23.5%). Pooled data from seven controlled studies showed that the prevalence of all headache types, including migraine, was not different from controls. Insufficient evidence was found for the concept of 'lupus headache'. No particular pathogenetic mechanism of headache in adult SLE patients has been identified, nor an association between headache and the disease status, including CNS involvement. There is no good evidence that headache is associated with anxiety and depression in SLE. Insufficient data (class III) do not allow safe conclusions for headache among paediatric SLE patients. These findings suggest that the occurrence of headache in adult SLE patients does

  3. Systems of evidence-based healthcare and personalised health information: some international and national trends.

    Science.gov (United States)

    Gordon, C; Gray, J A; Toth, B; Veloso, M

    2000-01-01

    In Europe, North America and elsewhere, growing interest has focussed on evidence-based healthcare systems, incorporating the deployment of practice guidelines, as a field of application for health telematics. The clinical benefit and technical feasibility of common European approaches to this task has recently been demonstrated. In Europe it is likely that, building on recent progress in electronic health record architecture (EHRA) standards, a sufficient state of maturity can be reached to justify initiation within CEN TC251 of a prestandards process on guideline content formats during the current 5th Framework of EC RT&D activity. There is now a similar impetus to agree standards for this field in North America. Thanks to fruitful EC-USA contacts during the 4th Framework programme, there is now a chance, given well-planned coordination, to establish a global consensus optimally suited to serve the world-wide delivery and application of evidence-based medicine. This review notes three factors which may accelerate progress to convergence: (1) revolutionary changes in the knowledge basis of professional/patient/public healthcare partnerships, involving the key role of the Web as a health knowledge resource for citizens, and a rapidly growing market for personalised health information and advice; (2) the emergence at national levels of digital warehouses of clinical guidelines and EBM knowledge resources, agencies which are capable of brokering common mark-up and interchange media definitions between knowledge providers, industry and healthcare organizations; (3) the closing gap in knowledge management technology, with the advent of XML and RDF, between approaches and services based respectively on text mark-up and knowledge-base paradigms. A current project in the UK National Health Service (the National electronic Library of Health) is cited as an example of a national initiative designed to harness these trends.

  4. Evidence for the presence of a type III secretion system in diffusely adhering Escherichia coli (DAEC).

    Science.gov (United States)

    Kyaw, C M; De Araujo, C R; Lima, M R; Gondim, E G S; Brígido, M M; Giugliano, L G

    2003-07-01

    Diffusely adhering Escherichia coli (E. coli) strains (DAEC) represent a potential cause of diarrhoea in infants, and the detection of type three secretion system (TTSS) genes in DAEC would substantiate their pathogenic nature. In this work, four isolates of DAEC, recovered from stools of diarrhoeic children, were analysed by PCR, in order to detect the presence of TTSS genes. Primers targeted to the escC, escJ, escN and escV, some of the most conserved TTSS genes in enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC), were used in order to verify the occurrence of homologous genes in our DAEC isolates. By this approach, we were able to characterise DNA fragments corresponding to putative escJ and escN genes in all DAEC isolates. Furthermore, DNA fragments homologous to the escC and escV genes were also amplified from all isolates. Besides the similarity found among the DAEC esc homologues with EPEC and EHEC esc genes, the nucleotide sequence analysis of the flanking regions of the amplified DNA fragments suggests that the putative DAEC esc genes are organised in the same manner as observed in EPEC and in EHEC strains. The results described here provide strong evidence for the presence of a TTSS in the DAEC strains analysed, implicating a pathogenic nature of these isolates.

  5. Evidence Report: Risk of Acute and Late Central Nervous System Effects from Radiation Exposure

    Science.gov (United States)

    Nelson, Gregory A.; Simonsen, Lisa; Huff, Janice L.

    2016-01-01

    Possible acute and late risks to the central nervous system (CNS) from galactic cosmic rays (GCR) and solar particle events (SPE) are concerns for human exploration of space. Acute CNS risks may include: altered cognitive function, reduced motor function, and behavioral changes, all of which may affect performance and human health. Late CNS risks may include neurological disorders such as Alzheimer's disease (AD), dementia and premature aging. Although detrimental CNS changes are observed in humans treated with high-dose radiation (e.g., gamma rays and 9 protons) for cancer and are supported by experimental evidence showing neurocognitive and behavioral effects in animal models, the significance of these results on the morbidity to astronauts has not been elucidated. There is a lack of human epidemiology data on which to base CNS risk estimates; therefore, risk projection based on scaling to human data, as done for cancer risk, is not possible for CNS risks. Research specific to the spaceflight environment using animal and cell models must be compiled to quantify the magnitude of CNS changes in order to estimate this risk and to establish validity of the current permissible exposure limits (PELs). In addition, the impact of radiation exposure in combination with individual sensitivity or other space flight factors, as well as assessment of the need for biological/pharmaceutical countermeasures, will be considered after further definition of CNS risk occurs.

  6. Preliminary evidence for a role of the adrenergic nervous system in generalized anxiety disorder

    Science.gov (United States)

    Zhang, Xiaobin; Norton, Joanna; Carrière, Isabelle; Ritchie, Karen; Chaudieu, Isabelle; Ryan, Joanne; Ancelin, Marie-Laure

    2017-01-01

    Generalized anxiety disorder (GAD) is a common chronic condition that is understudied compared to other psychiatric disorders. An altered adrenergic function has been reported in GAD, however direct evidence for genetic susceptibility is missing. This study evaluated the associations of gene variants in adrenergic receptors (ADRs) with GAD, with the involvement of stressful events. Data were obtained from 844 French community-dwelling elderly aged 65 or over. Anxiety disorders were assessed using the Mini-International Neuropsychiatry Interview, according to DSM-IV criteria. Eight single-nucleotide polymorphisms (SNPs) involved with adrenergic function were genotyped; adrenergic receptors alpha(1A) (ADRA1A), alpha(2A) (ADRA2A), and beta2 (ADRB2) and transcription factor TCF7L2. Questionnaires evaluated recent stressful life events as well as early environment during childhood and adolescence. Using multivariate logistic regression analyses four SNPs were significantly associated with GAD. A 4-fold modified risk was found with ADRA1A rs17426222 and rs573514, and ADRB2 rs1042713 which remained significant after Bonferroni correction. Certain variants may moderate the effect of adverse life events on the risk of GAD. Replication in larger samples is needed due to the small case number. This is the first study showing that ADR variants are susceptibility factors for GAD, further highlighting the critical role of the adrenergic nervous system in this disorder. PMID:28198454

  7. Preliminary evidence for a role of the adrenergic nervous system in generalized anxiety disorder.

    Science.gov (United States)

    Zhang, Xiaobin; Norton, Joanna; Carrière, Isabelle; Ritchie, Karen; Chaudieu, Isabelle; Ryan, Joanne; Ancelin, Marie-Laure

    2017-02-15

    Generalized anxiety disorder (GAD) is a common chronic condition that is understudied compared to other psychiatric disorders. An altered adrenergic function has been reported in GAD, however direct evidence for genetic susceptibility is missing. This study evaluated the associations of gene variants in adrenergic receptors (ADRs) with GAD, with the involvement of stressful events. Data were obtained from 844 French community-dwelling elderly aged 65 or over. Anxiety disorders were assessed using the Mini-International Neuropsychiatry Interview, according to DSM-IV criteria. Eight single-nucleotide polymorphisms (SNPs) involved with adrenergic function were genotyped; adrenergic receptors alpha(1A) (ADRA1A), alpha(2A) (ADRA2A), and beta2 (ADRB2) and transcription factor TCF7L2. Questionnaires evaluated recent stressful life events as well as early environment during childhood and adolescence. Using multivariate logistic regression analyses four SNPs were significantly associated with GAD. A 4-fold modified risk was found with ADRA1A rs17426222 and rs573514, and ADRB2 rs1042713 which remained significant after Bonferroni correction. Certain variants may moderate the effect of adverse life events on the risk of GAD. Replication in larger samples is needed due to the small case number. This is the first study showing that ADR variants are susceptibility factors for GAD, further highlighting the critical role of the adrenergic nervous system in this disorder.

  8. Evidence of active tectonics on a Roman aqueduct system (II-III century A.D.) near Rome, Italy

    Science.gov (United States)

    Marra, Fabrizio; Montone, Paola; Pirro, Mario; Boschi, Enzo

    2004-04-01

    In this paper we describe evidence of strong tectonic deformation affecting two aqueducts of Roman age (II-III century A.D.). The channels are located approximately 20 km northeast of Rome along the ancient Via Tiburtina. Brittle and ductile deformation affects these two structures, including extensional joint systems, NE-oriented faults, and horizontal distortion. This deformation is consistent with right-lateral movement on major N-striking faults, and represents the first evidence that tectonic deformation took place in historical times in the vicinity of Rome, with local strike-slip movement superimposed on a regional extensional fault system.

  9. Road traffic related mortality in Vietnam: Evidence for policy from a national sample mortality surveillance system

    Directory of Open Access Journals (Sweden)

    Ngo Anh D

    2012-07-01

    Full Text Available Abstract Background Road traffic injuries (RTIs are among the leading causes of mortality in Vietnam. However, mortality data collection systems in Vietnam in general and for RTIs in particular, remain inconsistent and incomplete. Underlying distributions of external causes and body injuries are not available from routine data collection systems or from studies till date. This paper presents characteristics, user type pattern, seasonal distribution, and causes of 1,061 deaths attributable to road crashes ascertained from a national sample mortality surveillance system in Vietnam over a two-year period (2008 and 2009. Methods A sample mortality surveillance system was designed for Vietnam, comprising 192 communes in 16 provinces, accounting for approximately 3% of the Vietnamese population. Deaths were identified from commune level data sources, and followed up by verbal autopsy (VA based ascertainment of cause of death. Age-standardised mortality rates from RTIs were computed. VA questionnaires were analysed in depth to derive descriptive characteristics of RTI deaths in the sample. Results The age-standardized mortality rates from RTIs were 33.5 and 8.5 per 100,000 for males and females respectively. Majority of deaths were males (79%. Seventy three percent of all deaths were aged from 15 to 49 years and 58% were motorcycle users. As high as 80% of deaths occurred on the day of injury, 42% occurred prior to arrival at hospital, and a further 29% occurred on-site. Direct causes of death were identified for 446 deaths (42% with head injuries being the most common cause attributable to road traffic injuries overall (79% and to motorcycle crashes in particular (78%. Conclusion The VA method can provide a useful data source to analyse RTI mortality. The observed considerable mortality from head injuries among motorcycle users highlights the need to evaluate current practice and effectiveness of motorcycle helmet use in Vietnam. The high number of

  10. Evaluation of the Performance of Routine Information System Management (PRISM framework: evidence from Uganda

    Directory of Open Access Journals (Sweden)

    Aqil Anwer

    2010-07-01

    Full Text Available Abstract Background Sound policy, resource allocation and day-to-day management decisions in the health sector require timely information from routine health information systems (RHIS. In most low- and middle-income countries, the RHIS is viewed as being inadequate in providing quality data and continuous information that can be used to help improve health system performance. In addition, there is limited evidence on the effectiveness of RHIS strengthening interventions in improving data quality and use. The purpose of this study is to evaluate the usefulness of the newly developed Performance of Routine Information System Management (PRISM framework, which consists of a conceptual framework and associated data collection and analysis tools to assess, design, strengthen and evaluate RHIS. The specific objectives of the study are: a to assess the reliability and validity of the PRISM instruments and b to assess the validity of the PRISM conceptual framework. Methods Facility- and worker-level data were collected from 110 health care facilities in twelve districts in Uganda in 2004 and 2007 using records reviews, structured interviews and self-administered questionnaires. The analysis procedures include Cronbach's alpha to assess internal consistency of selected instruments, test-retest analysis to assess the reliability and sensitivity of the instruments, and bivariate and multivariate statistical techniques to assess validity of the PRISM instruments and conceptual framework. Results Cronbach's alpha analysis suggests high reliability (0.7 or greater for the indices measuring a promotion of a culture of information, RHIS tasks self-efficacy and motivation. The study results also suggest that a promotion of a culture of information influences RHIS tasks self-efficacy, RHIS tasks competence and motivation, and that self-efficacy and the presence of RHIS staff have a direct influence on the use of RHIS information, a key aspect of RHIS performance

  11. Metagenomic Evidence for the Presence of Comammox Nitrospira-Like Bacteria in a Drinking Water System.

    Science.gov (United States)

    Pinto, Ameet J; Marcus, Daniel N; Ijaz, Umer Zeeshan; Bautista-de Lose Santos, Quyen Melina; Dick, Gregory J; Raskin, Lutgarde

    2016-01-01

    We report metagenomic evidence for the presence of a Nitrospira-like organism with the metabolic potential to perform the complete oxidation of ammonia to nitrate (i.e., it is a complete ammonia oxidizer [comammox]) in a drinking water system. This metagenome bin was discovered through shotgun DNA sequencing of samples from biologically active filters at the drinking water treatment plant in Ann Arbor, MI. Ribosomal proteins, 16S rRNA, and nxrA gene analyses confirmed that this genome is related to Nitrospira-like nitrite-oxidizing bacteria. The presence of the full suite of ammonia oxidation genes, including ammonia monooxygenase and hydroxylamine dehydrogenase, on a single ungapped scaffold within this metagenome bin suggests the presence of recently discovered comammox potential. Evaluations based on coverage and k-mer frequency distribution, use of two different genome-binning approaches, and nucleic acid and protein similarity analyses support the presence of this scaffold within the Nitrospira metagenome bin. The amoA gene found in this metagenome bin is divergent from those of canonical ammonia and methane oxidizers and clusters closely with the unusual amoA gene of comammox Nitrospira. This finding suggests that previously reported imbalances in abundances of nitrite- and ammonia-oxidizing bacteria/archaea may likely be explained by the capacity of Nitrospira-like organisms to completely oxidize ammonia. This finding might have significant implications for our understanding of microbially mediated nitrogen transformations in engineered and natural systems. IMPORTANCE Nitrification plays an important role in regulating the concentrations of inorganic nitrogen species in a range of environments, from drinking water and wastewater treatment plants to the oceans. Until recently, aerobic nitrification was considered to be a two-step process involving ammonia-oxidizing bacteria or archaea and nitrite-oxidizing bacteria. This process requires close cooperation

  12. Geophysical evidence for Quaternary deformation within the offshore San Andreas Fault System, Point Reyes Peninsula, California

    Science.gov (United States)

    Stozek, B.

    2010-12-01

    Our previous work studying the rate and style of uplift of marine terraces on the Point Reyes Peninsula indicates the peninsula has been undergoing differential uplift due to interacting fault geometries in the offshore zone. To better understand offshore fault interactions, recently collected mini-sparker seismic reflection data acquired by the USGS and multi-beam bathymetric data acquired by California State University at Monterey Bay within the 3-mile (5 km) limit offshore of the Point Reyes Peninsula, are being used to reinterpret the tectono-stratigraphic framework of the San Andreas fault (SAF) system. Eight offshore Shell exploratory well logs that provide seismic velocity and paleontologic data are being used in conjunction with industry multichannel (deep-penetration) seismic reflection profiles to provide age control and extend the analyses beyond 3 mile limit of the high-resolution data. Isopach and structure maps of key stratigraphic intervals were generated to show how the stratigraphic units are influenced by fault interactions. These datasets allow for new interpretations of the offshore Neogene stratigraphy and the evolution of the Point Reyes fault, an offshore component of the SAF system. Observations of Quaternary sedimentary sequences in the high-resolution mini-sparker dataset provide evidence of localized areas of subsidence and uplift within the offshore SAF system. For example, the most recent angular unconformity above the Point Reyes fault deepens to the north where the fault bends from an east-west to a more northerly orientation. Stratigraphic horizons in the offshore zone are correlated with the same geologic units exposed on the Point Reyes Peninsula. Both unconformity-bounded sedimentary sequences mapped on reflection profiles in the offshore and marine terraces that have been uplifted on the peninsula are tied to sea-level fluctuations. Our new interpretation of the Point Reyes fault zone will be incorporated into a kinematic fault

  13. Mucopolysaccharidosis type IVA: evidence of primary and secondary central nervous system involvement.

    Science.gov (United States)

    Borlot, Felippe; Arantes, Paula Ricci; Quaio, Caio Robledo; Franco, José Francisco da Silva; Lourenço, Charles Marques; Gomy, Israel; Bertola, Debora Romeo; Kim, Chong Ae

    2014-05-01

    Mucopolysaccharidosis type IVA is a rare lysosomal storage disease caused by a deficiency of N-acetylgalactosamine 6-sulfatase. Studies usually focus on skeletal abnormalities and their consequences. This study explores the neurological manifestations in a cohort of mucopolysaccharidosis type IVA patients, with a detailed focus on brain and spinal magnetic resonance imaging (MRI) findings. We performed a cross-sectional study involving nine patients with a biochemical confirmation of mucopolysaccharidosis type IVA. The protocol consists of a comprehensive clinical examination and brain and spinal cord MRI analysis for all subjects. The mean age was 16.4 years (±5.7) and the mean onset of symptoms was 11.5 months (±6.3). Overall, cognition was spared in all but one patient and motor weakness was a constant finding in all patients. Deep sensation impairment was found in six patients. The brain MRIs showed non-specific white matter changes in two patients. Other abnormalities such as clival hypoplasia, basilar invagination, and arachnoid cists appeared in seven of the nine patients. Eight patients presented spinal cord compression, and in three of them, two spinal levels were compromised. Odontoid hypoplasia and degenerative features in the neuroaxis were present in all patients. Our experience with mucopolysaccharidosis type IVA patients supports the evidence of central nervous system involvement. We emphasize the importance of regular clinical assessments with complete MRI studies, as an attempt to detect the early signs of spinal cord compression. This evaluation may be especially important before surgical interventions, as occult lesions may become symptomatic and promote postoperative unfavorable outcomes.

  14. In vivo evidence that TRAF4 is required for central nervous system myelin homeostasis.

    Directory of Open Access Journals (Sweden)

    Sébastien Blaise

    Full Text Available Tumor Necrosis Factor Receptor-Associated Factors (TRAFs are major signal transducers for the TNF and interleukin-1/Toll-like receptor superfamilies. However, TRAF4 does not fit the paradigm of TRAF function in immune and inflammatory responses. Its physiological and molecular functions remain poorly understood. Behavorial analyses show that TRAF4-deficient mice (TRAF4-KO exhibit altered locomotion coordination typical of ataxia. TRAF4-KO central nervous system (CNS ultrastructure shows strong myelin perturbation including disorganized layers and disturbances in paranode organization. TRAF4 was previously reported to be expressed by CNS neurons. Using primary cell culture, we now show that TRAF4 is also expressed by oligodendrocytes, at all stages of their differentiation. Moreover, histology and electron microscopy show degeneration of a high number of Purkinje cells in TRAF4-KO mice, that was confirmed by increased expression of the Bax pro-apoptotic marker (immunofluorescence, TUNEL analysis, and caspase-3 activation and PARP1 cleavage (western blotting. Consistent with this phenotype, MAG and NogoA, two myelin-induced neurite outgrowth inhibitors, and their neuron partners, NgR and p75NTR were overexpressed (Q-RT-PCR and western blotting. The strong increased phosphorylation of Rock2, a RhoA downstream target, indicated that the NgR/p75NTR/RhoA signaling pathway, known to induce actin cytoskeleton rearrangement that favors axon regeneration inhibition and neuron apoptosis, is activated in the absence of TRAF4 (western blotting. Altogether, these results provide conclusive evidence for the pivotal contribution of TRAF4 to myelination and to cerebellar homeostasis, and link the loss of TRAF4 function to demyelinating or neurodegenerative diseases.

  15. Floristic indicators of tropical landuse systems: Evidence from mining areas in Southwestern Nigeria

    Directory of Open Access Journals (Sweden)

    Sehinde Akinbiola

    2016-07-01

    Full Text Available Most forests in the tropics have not only been reduced in size but have also experienced forest degradation. The delicate balance of the components of the forest ecosystem has been altered largely by the landuse systems which have resulted in the disappearance of some species and the introduction of new ones. In order to understand the influence of human disturbance caused by artisanal mining on plant biodiversity and the physical environment, this study assessed changes in vegetation characteristics using plant functional groups, such as invasive, pioneer and understory species. The study was conducted at two sites in two Southwestern states of Nigeria, Itagunmodi in Atakumosa West Local Government Area of Osun State and Olode in Oluyole Local Government Area of Oyo State. Complete enumerations of woody, non-woody and herbaceous plant species were carried out in 20 m by 20 m plots selected using stratified random sampling as representative of landuse classes: freshly mined (6 months and a control plot (secondary forest. The results showed that the control plot in Itagunmodi had undergone degradation as indicated by the presence of Alchornea laxiflora, Geophilia obvallata, Musa sapientum,Elaeis guineensis and Keetia hispida. However, if left undisturbed, it has the potential of regeneration back to its original state because of its woody tree species composition and lianas (Triclisia gilletii. In addition the forest soils in the mines had been exposed to direct insolation for a long period, and the soil structure and texture have been affected, consequently altering the viability of the seed bank. Poaceae and Papilionoideae were the most common in the freshly mined plots while invasive species were the most common in abandoned mined plots. In conclusion, the floristic composition in the mining sites has been altered and there was no clear evidence that regrowth would bring restoration of the lost ecosystem services.

  16. Evidence for Methyl-Compound-Activated Life in Coal Bed System 2 km Below Sea Floor

    Science.gov (United States)

    Trembath-reichert, E.; Morono, Y.; Dawson, K.; Wanger, G.; Bowles, M.; Heuer, V.; Hinrichs, K. U.; Inagaki, F.; Orphan, V. J.

    2014-12-01

    IODP Expedition 337 set the record for deepest marine scientific drilling down to 2.4 kmbsf. This cruise also had the unique opportunity to retrieve deep cores from the Shimokita coal bed system in Japan with the aseptic and anaerobic conditions necessary to look for deep life. Onboard scientists prepared nearly 1,700 microbiology samples shared among five different countries to study life in the deep biosphere. Samples spanned over 1 km in sampling depths and include representatives of shale, sandstone, and coal lithologies. Findings from previous IODP and deep mine expeditions suggest the genetic potential for methylotrophy in the deep subsurface, but it has yet to be observed in incubations. A subset of Expedition 337 anoxic incubations were prepared with a range of 13C-methyl substrates (methane, methylamine, and methanol) and maintained near in situ temperatures. To observe 13C methyl compound metabolism over time, we monitored the δ13C of the dissolved inorganic carbon (by-product of methyl compound metabolism) over a period of 1.5 years. Elemental analysis (EA), ion chromatograph (IC), 13C volatile fatty acid (VFA), and mineral-associated microscopy data were also collected to constrain initial and endpoint conditions in these incubations. Our geochemical evidence suggests that the coal horizon incubated with 13C-methane showed the highest activity of all methyl incubations. This provides the first known observation of methane-activated metabolism in the deep biosphere, and suggests there are not only active cells in the deeply buried terrigenous coal bed at Shimokita, but the presence of a microbial community activated by methylotrophic compounds.

  17. A model for Ischia hydrothermal system: Evidences from the chemistry of thermal groundwaters

    Science.gov (United States)

    Di Napoli, R.; Aiuppa, A.; Bellomo, S.; Brusca, L.; D'Alessandro, W.; Candela, E. Gagliano; Longo, M.; Pecoraino, G.; Valenza, M.

    2009-10-01

    Ischia volcano, in Central Italy, has long been known for its copious surface hydrothermal manifestations, signs of a pervasive circulation of hot fluids in the subsurface. Because of the significant chemical heterogeneity of fumarolic gas discharges and hot spring discharges, evidences of a complex hydrothermal setting, a definite model of fluid circulation at depth is currently unavailable, in spite of the several previous efforts. Here, we report on the chemical and isotopic composition of 120 groundwater samples, collected during several sampling surveys from 2002 to 2007. The acquired data suggest that the composition of surface manifestations reflect contributions from meteoric water, sea water, and thermal fluids rising from two distinct hydrothermal reservoir, with equilibrium temperatures of respectively ~ 150 °C and ~ 270 °C, and depths of 150-300 m and > 300 m (but possibly > 1000 m). We also make use of an isotopic characterization of the dissolved gas phase in thermal waters to demonstrate that the Ischia hydrothermal system is currently supplied by a deep-rising gas component (DGC), characterized by CO 2 ~ 97.7 ± 1.2 vol.% (on a water-free basis), δ13C CO2 = - 3.51 ± 0.9‰, and helium isotopic ratio of about 3.5 Ra ( 3He/ 4He ratio normalized to the air ratio, Ra), likely magmatic in origin. An assessment of the thermal budget for Ischia hydrothermal system is also presented, in the attempt to derive a first estimate of the size and rate of degassing of the magmatic reservoir feeding the gas emissions. We calculate that a heat flow of about 153-222 MW presently drives hydrothermal circulation on the island, which we suggest is supplied in convective form (e.g., by the ascent of a high- T magmatic vapour phase) by complete degassing of 2.2-3.3 · 10 7 m 3 yr - 1 of trachytic magma (with ~ 2.1 wt.% dissolved H 2O content). If extrapolated to entire period of quiescence lasting since the Arso eruption in 1302 A.D., this volume corresponds to 1

  18. [Evidence is good for your health system: policy reform to remedy catastrophic and impoverishing health spending in Mexico].

    Science.gov (United States)

    Knaul, Felicia Marie; Arreola-Ornelas, Héctor; Méndez-Carniado, Oscar; Bryson-Cahn, Chloe; Barofsky, Jeremy; Maguire, Rachel; Miranda, Martha; Sesma, Sergio

    2007-01-01

    Absence of financial protection in health is a recently diagnosed "disease" of health systems. The most obvious symptom is that families face economic ruin and poverty as a consequence of financing their health care. Mexico was one of the first countries to diagnose the problem, attribute it to lack of financial protection, and propose systemic therapy through health reform. In this article we assess how Mexico turned evidence on catastrophic and impoverishing health spending into a catalyst for institutional renovation through the reform that created Seguro Popular de Salud (Popular Health Insurance). We present 15-year trends on the evolution of catastrophic and impoverishing health spending, including evidence on how the situation is improving. The results of the Mexican experience suggest an important role for the organisation and financing of the health system in reducing impoverishment and protecting households during periods of individual and collective financial crisis.

  19. Evidence is good for your health system: policy reform to remedy catastrophic and impoverishing health spending in Mexico.

    Science.gov (United States)

    Knaul, Felicia Marie; Arreola-Ornelas, Héctor; Méndez-Carniado, Oscar; Bryson-Cahn, Chloe; Barofsky, Jeremy; Maguire, Rachel; Miranda, Martha; Sesma, Sergio

    2006-11-18

    Absence of financial protection in health is a recently diagnosed "disease" of health systems. The most obvious symptom is that families face economic ruin and poverty as a consequence of financing their health care. Mexico was one of the first countries to diagnose the problem, attribute it to lack of financial protection, and propose systemic therapy through health reform. In this article we assess how Mexico turned evidence on catastrophic and impoverishing health spending into a catalyst for institutional renovation through the reform that created Seguro Popular (Popular Health Insurance). We present 15-year trends on the evolution of catastrophic and impoverishing health spending, including evidence on how the situation is improving. The results of the Mexican experience suggest an important role for the organisation and financing of the health system in reducing impoverishment and protecting households during periods of individual and collective financial crisis.

  20. Molecular evidence for a functional ecdysone signaling system in Brugia malayi.

    Directory of Open Access Journals (Sweden)

    George Tzertzinis

    Full Text Available BACKGROUND: Filarial nematodes, including Brugia malayi, the causative agent of lymphatic filariasis, undergo molting in both arthropod and mammalian hosts to complete their life cycles. An understanding of how these parasites cross developmental checkpoints may reveal potential targets for intervention. Pharmacological evidence suggests that ecdysteroids play a role in parasitic nematode molting and fertility although their specific function remains unknown. In insects, ecdysone triggers molting through the activation of the ecdysone receptor: a heterodimer of EcR (ecdysone receptor and USP (Ultraspiracle. METHODS AND FINDINGS: We report the cloning and characterization of a B. malayi EcR homologue (Bma-EcR. Bma-EcR dimerizes with insect and nematode USP/RXRs and binds to DNA encoding a canonical ecdysone response element (EcRE. In support of the existence of an active ecdysone receptor in Brugia we also cloned a Brugia rxr (retinoid X receptor homolog (Bma-RXR and demonstrate that Bma-EcR and Bma-RXR interact to form an active heterodimer using a mammalian two-hybrid activation assay. The Bma-EcR ligand-binding domain (LBD exhibits ligand-dependent transactivation via a GAL4 fusion protein combined with a chimeric RXR in mammalian cells treated with Ponasterone-A or a synthetic ecdysone agonist. Furthermore, we demonstrate specific up-regulation of reporter gene activity in transgenic B. malayi embryos transfected with a luciferase construct controlled by an EcRE engineered in a B. malayi promoter, in the presence of 20-hydroxy-ecdysone. CONCLUSIONS: Our study identifies and characterizes the two components (Bma-EcR and Bma-RXR necessary for constituting a functional ecdysteroid receptor in B. malayi. Importantly, the ligand binding domain of BmaEcR is shown to be capable of responding to ecdysteroid ligands, and conversely, ecdysteroids can activate transcription of genes downstream of an EcRE in live B. malayi embryos. These results together

  1. Visual Cortex Plasticity Following Peripheral Damage To The Visual System: fMRI Evidence.

    Science.gov (United States)

    Lemos, João; Pereira, Daniela; Castelo-Branco, Miguel

    2016-10-01

    Over the last two decades, functional magnetic resonance imaging (fMRI) has become a powerful research method to investigate cortical visual plasticity. Abnormal fMRI response patterns have been occasionally detected in the visually deprived cortex of patients with bilateral retinal diseases. Controversy remains whether these observations indicate structural reorganization of the visual cortex or unmasking of previously silent cortico-cortical connections. In optic nerve diseases, there is weak evidence showing that early visual cortex seems to lack reorganization, while higher-order visual areas undergo plastic changes which may contribute to optimise visual function. There is however accumulating imaging evidence demonstrating trans-synaptic degeneration of the visual cortex in patients with disease of the anterior visual pathways. This may preclude the use of restorative treatments in these patients. Here, we review and update the body of fMRI evidence on visual cortical plasticity.

  2. Bridging evidence, policy, and practice to strengthen health systems for improved maternal and newborn health in Pakistan.

    Science.gov (United States)

    Hirose, Atsumi; Hall, Sarah; Memon, Zahid; Hussein, Julia

    2015-11-25

    Policy and decision making should be based on evidence, but translating evidence into policy and practice is often sporadic and slow. It is recognised that the relationship between research and policy uptake is complex and that dissemination of research findings is necessary, but insufficient, for policy uptake. Political, social, and economic context, use of (credible) data and dialogues between and across networks of researchers and policymakers play important roles in evidence uptake. Advocacy is the process of mobilising political and public opinions to achieve specific aims and its role is crucial in mobilising key actors to push for policy uptake. Advocacy and research groups (i.e. those who would like to see research evidence used by policymakers) may use different approaches and tools to stimulate the diffusion of research findings. The use of mass- and social media, communication with study participants, and the involvement of stakeholders at the early stages of research development are examples of the approaches that can be employed to stimulate diffusion of evidence and increase evidence uptake. The Research and Advocacy Fund (RAF) for Maternal and Newborn Health (MNH) worked within the health system context in Pakistan with the aim of espousing the principles of evidence, advocacy, and dissemination to improve MNH outcomes. The articles included in this special issue are outputs of RAF and highlight where RAF's approaches contributed to MNH policy reforms. The papers discuss critical health system issues facing Pakistan, including service delivery components, demand creation, equitable access, transportation interventions for improved referrals, availability of medicines and equipment, and health workforce needs. In addition to these tangible elements, the health system 'software', i.e. the power and the political and social contexts, is also represented in the collection. These articles highlight three considerations for the future: the growing

  3. Numerical evidence for approximate consistency and Markovianity of some quantum histories in a class of finite closed spin systems.

    Science.gov (United States)

    Schmidtke, Daniel; Gemmer, Jochen

    2016-01-01

    Closed quantum systems obey the Schrödinger equation, whereas nonequilibrium behavior of many systems is routinely described in terms of classical, Markovian stochastic processes. Evidently, there are fundamental differences between those two types of behavior. We discuss the conditions under which the unitary dynamics may be mapped onto pertinent classical stochastic processes. This is first principally addressed based on the notions of "consistency" and "Markovianity." Numerical data are presented that show that the above conditions are to good approximation fulfilled for Heisenberg-type spin models comprising 12-20 spins. The accuracy to which these conditions are met increases with system size.

  4. A Map-Matching Algorithm for GPS/DR Integrated Navigation Systems Based on Dempster-Shafer Evidence Reasoning

    Institute of Scientific and Technical Information of China (English)

    CHEN Ze-wang; YUAN Xin

    2004-01-01

    GPS (Global Positioning System) has been widely used in car navigation systems. Most car navigation systems estimate the car position from GPS and DR (dead reckoning). However, the unknown GPS noise characteristic and the unbounded DR accumulation of errors over time make the position information with undesirable position errors. The map matching can improve the position accuracy and availability of the vehicular position system. In this paper, general principle of map matching is investigated according to segmentation and feature extraction, and a map matching algorithm based on D-S (Dempster-Shafer) evidence reasoning for GPS integrated navigation system is proposed, which can find the exact road on which a car moves. For the experiments, a car navigation system is developed with some sensors and the field test demonstrates the effectiveness and applicability of the algorithm for the car location and navigation.

  5. Using a training-of-trainers approach and proactive technical assistance to bring evidence based programs to scale: an operationalization of the interactive systems framework's support system.

    Science.gov (United States)

    Ray, Marilyn L; Wilson, Mary Martha; Wandersman, Abraham; Meyers, Duncan C; Katz, Jason

    2012-12-01

    Bringing evidence based programs to scale was a major initial impetus for the development of the Interactive Systems Framework for Dissemination and Implementation (ISF). The ISF demonstrates the importance of the Support System in facilitating the uptake of innovations in the community (the Delivery System). Two strategies that members of the Support System commonly use are training-of-trainers (TOT) models and technical assistance (TA). In this article, we focus on the role of the Support System in bringing evidence-based programs (EBPs) to scale in the Delivery System using a case example, with special attention on two strategies employed by Support Systems-training-of-trainers (TOT) and proactive technical assistance. We then report on findings from a case example from the Promoting Science Based Approaches to Teen Pregnancy Prevention project that furthers our conceptualization of these strategies and the evidence base for them. We also report on the limitations in the literature regarding research on TOTs and proactive TA and provide suggestions for future research on TOTs and proactive TA that will enhance the science and practice of support in the ISF.

  6. Evidence that deletion at FCGR3B is a risk factor for systemic sclerosis

    NARCIS (Netherlands)

    McKinney, C.; Broen, J.C.A.; Vonk, M.C.; Beretta, L.; Hesselstrand, R.; Hunzelmann, N.; Riemekasten, G.; Scorza, R.; Simeon, C.P.; Fonollosa, V.; Carreira, P.E.; Ortego-Centeno, N.; Gonzalez-Gay, M.A.; Airo, P.; Coenen, M.J.; Martin, J.; Radstake, T.R.D.J.; Merriman, T.R.

    2012-01-01

    There is increasing evidence that gene copy number (CN) variation influences clinical phenotype. The low-affinity Fc receptor 3B (FCGR3B) located in the FCGR gene cluster is a CN polymorphic gene involved in the recruitment of polymorphonuclear neutrophils to sites of inflammation and their activati

  7. New evidence of transient complex oscillations in a closed, well-stirred Belousov-Zhabotinsky system

    Directory of Open Access Journals (Sweden)

    LJILJANA KOLAR-ANIC

    2006-06-01

    Full Text Available Some new experimental evidence of complex irregular oscillations in the Belousov–Zhabotinsky reaction realized in a batch reactor is presented. The results were obtained under relatively low cerium and malonic acid concentrations. One-dimensionalmaps were used for general discussion, and, particularly, for the influence of noise on the evolution of the oscillations.

  8. Levels of Evidence: Universal Newborn Hearing Screening (UNHS) and Early Hearing Detection and Intervention Systems (EHDI)

    Science.gov (United States)

    Yoshinaga-Itano, Christine

    2004-01-01

    Levels of evidence differ according to the audience addressed. Implementation of universal newborn hearing screening requires responses to a complex myriad of diverse groups: the general public, families with children who are deaf or hard of hearing, the deaf and hard of hearing communities, hospital administrators, physicians (pediatricians,…

  9. Evidence for community structure and habitat partitioning in coastal dune stiletto flies at the Guadalupe-Nipomo dunes system, California

    OpenAIRE

    Holston, Kevin C.

    2005-01-01

    This study provides empirical evidence for habitat selection by North American species of stiletto flies (Diptera: Therevidae), based on local distributions of adults and immatures, and the first hypothesis of community assemblages proposed for a stiletto fly community. Sites at three localities within the Guadalupe-Nipomo dune system were sampled for stiletto flies in 1997 and 2001 by sifting sand, malaise trapping, and hand netting. Nine species were collected from four ecological zones and...

  10. Child Disaster Mental Health Services: a Review of the System of Care, Assessment Approaches, and Evidence Base for Intervention.

    Science.gov (United States)

    Pfefferbaum, Betty; North, Carol S

    2016-01-01

    Several decades of research have informed our knowledge of children's reactions to disasters and the factors that influence their reactions. This article describes the system of care for child disaster mental health services using population risk to determine needed services and a stepped care approach built on assessment and monitoring to advance children to appropriate services. To assess the evidence base for disaster interventions, recent reviews of numerous child disaster mental health interventions are summarized.

  11. A Novel Evaluation Model for Hybrid Power System Based on Vague Set and Dempster-Shafer Evidence Theory

    Directory of Open Access Journals (Sweden)

    Dongxiao Niu

    2012-01-01

    Full Text Available Because clean energy and traditional energy have different advantages and disadvantages, it is of great significance to evaluate comprehensive benefits for hybrid power systems. Based on thorough analysis of important characters on hybrid power systems, an index system including security, economic benefit, environmental benefit, and social benefit is established in this paper. Due to advantages of processing abundant uncertain and fuzzy information, vague set is used to determine the decision matrix. Convert vague decision matrix to real one by vague combination ruleand determine uncertain degrees of different indexes by grey incidence analysis, then the mass functions of different comment set in different indexes are obtained. Information can be fused in accordance with Dempster-Shafer (D-S combination rule and the evaluation result is got by vague set and D-S evidence theory. A simulation of hybrid power system including thermal power, wind power, and photovoltaic power in China is provided to demonstrate the effectiveness and potential of the proposed design scheme. It can be clearly seen that the uncertainties in decision making can be dramatically decreased compared with existing methods in the literature. The actual implementation results illustrate that the proposed index system and evaluation model based on vague set and D-S evidence theory are effective and practical to evaluate comprehensive benefit of hybrid power system.

  12. Amino acid transport by prosthecae of Asticcacaulis biprosthecum: evidence for a broad-range transport system.

    Science.gov (United States)

    Tam, E; Pate, J L

    1985-10-01

    Prosthecae purified from cells of Asticcaulis biprosthecum possess active transport systems that transport all 20 amino acids tested. Using ascorbate-reduced phenazine methosulphate in the presence of oxygen, all 20 amino acids are accumulated against a concentration gradient by isolated prosthecae. Results of experiments testing the inhibition of transport of one amino acid by another, and of experiments testing the exchange of exogenous amino acids with those preloaded in prosthecae, along with characteristics of mutants defective in amino acid transport, suggest the presence in prosthecae of three amino acid transport systems. One, the general or G system, transports at least 18 of the 20 amino acids tested. Another system, referred to as the proline or P system, transports seven amino acids (including proline) that are also transported by the G system. The third system transports only glutamate and aspartate, and is referred to as the acidic amino acid transport system or A system.

  13. Sediment Ecosystem Assessment Protocol (SEAP): An Accurate and Integrated Weight-of-Evidence Based System

    Science.gov (United States)

    2011-01-01

    the environmental variables inputs for each model were analyzed for collinearity (SAS v. 9) by computing variance inflation factors ( VIF ) using the...raw sample data. A VIF value of >2.5 was considered evidence of problematic collinearity, and if this was found with model input variables, the...variable with the strongest correlation to others and the weakest WOE spatial association was removed from input to the model until all VIF values were

  14. Building an evidence-based multitiered system of supports for high-risk youth and communities.

    Science.gov (United States)

    Kingston, Beverly E; Mihalic, Sharon F; Sigel, Eric J

    2016-03-01

    The mental, emotional and behavioral health problems of high-risk youth and youth living in high-risk communities are not inevitable and can be prevented. A shift from the nation's focus on treating disease and illness after it occurs to a concentrated effort on preventing the root causes of these problems is needed. Prevention science suggests a comprehensive multitiered approach that provides evidence-based prevention supports for children and youth at each developmental stage and across multiple social contexts is likely to result in the greatest health impact and return on investment. However, actually implementing this approach at a neighborhood level has remained a challenge and an ongoing research gap especially in high-risk communities. This article describes a process and provides a case study example for implementing a comprehensive, multitiered approach in a high-risk community. This includes assessing and prioritizing the specific needs of individuals and communities; selecting evidence-based programs based upon assessed needs; and creating a continuum of programs to improve the health and well-being of youth across developmental age spans, social contexts, and levels of risk. Operational details and challenges for organizing and implementing this comprehensive approach are also described. We estimate that the collective impact of a multitiered evidence-based approach, implemented with fidelity, could conservatively result in a 30 to 40% reduction in problem behaviors. (PsycINFO Database Record

  15. HYPERACTIVE TISSUE RENIN-ANGIOTENSIN SYSTEMS IN CARDIOVASCULAR DYSFUNCTION - EXPERIMENTAL-EVIDENCE AND CLINICAL HYPOTHESES

    NARCIS (Netherlands)

    PINTO, YM; BUIKEMA, H; VANGILST, WH

    1995-01-01

    In this review, hypotheses are discussed with regard to the role of local, tissue renin-angiotensin systems in the progression of cardiovascular dysfunction. After local renin-anglotensin systems had been described as functionally distinct systems, recent experimental studies have suggested an assoc

  16. [Current state of digestive system robotic surgery in the light of evidence based medicine].

    Science.gov (United States)

    Ortiz Oshiro, Elena; Fernández-Represa, Jesús Alvarez

    2009-03-01

    The incorporation of robotics in minimally invasive surgery has had mixed reception in the different fields of digestive surgery. Nowadays we are exposed to a continuous stream of publications on robotic approach techniques and outcomes, which do not always provide objective criteria and whose value, through scientific evidence analysis, is sometimes arguable. With the aim of shedding light on current knowledge on digestive robotic surgery and giving an update of its possibilities, the authors analyse the abundant literature available on the different digestive robotic surgery procedures, and sum up their own experience.

  17. INSTABILITY IN THE CEE BANKING SYSTEM. EVIDENCE FROM THE RECENT FINANCIAL CRISIS

    Directory of Open Access Journals (Sweden)

    Renata Karkowska

    2013-12-01

    Full Text Available Sparked by the recent great recession and the role of financial markets, considerable interest exists among researchers within both the academic and public community in measuring and modeling systemic risk. This article introduces a new framework for measuring systemic risk by using a risk-adjusted balance sheet approach. In this regard, the analysis of 21 largest commercial banks operating in 7 countries from Central and Eastern Europe, shows potential risk which could threaten all the financial system. The paper concludes new directions for measuring systemic risk by using Merton model. It shows how risk management tools can be applied in new ways to measure and analyze systemic risk in European banking system.

  18. Scientific Evidence-Based Effects of Hydrotherapy on Various Systems of the Body

    OpenAIRE

    Mooventhan, A; L Nivethitha

    2014-01-01

    The use of water for various treatments (hydrotherapy) is probably as old as mankind. Hydrotherapy is one of the basic methods of treatment widely used in the system of natural medicine, which is also called as water therapy, aquatic therapy, pool therapy, and balneotherapy. Use of water in various forms and in various temperatures can produce different effects on different system of the body. Many studies/reviews reported the effects of hydrotherapy only on very few systems and there is lack...

  19. The Galileo System of Measurement: Preliminary Evidence for Precision, Stability, and Equivalance to Traditional Measures

    Science.gov (United States)

    Gillham, James; Woelfel, Joseph

    1977-01-01

    Describes the Galileo system of measurement operations including reliability and validity data. Illustrations of some of the relations between Galileo measures and traditional procedures are provided. (MH)

  20. Autonomic nervous system dysfunction in obesity and Prader-Willi syndrome: current evidence and implications for future obesity therapies.

    Science.gov (United States)

    Haqq, A M; DeLorey, D S; Sharma, A M; Freemark, M; Kreier, F; Mackenzie, M L; Richer, L P

    2011-08-01

    The autonomic nervous system (ANS) controls essential functions like breathing, heart rate, digestion, body temperature and hormone levels. Evidence suggests that ANS dysfunction is associated with adult and childhood obesity and plays a role in the distribution of total body fat and the development of obesity-related complications in humans. This review summarizes our current understanding of ANS involvement in the pathogenesis of obesity and Prader-Willi syndrome. Available evidence of ANS dysfunction in the control of energy balance is limited and, in some cases, contradictory. Further investigation in this area is warranted in order to better understand the important contributions of the ANS to regulation of body fat, development of obesity and its comorbidities. Results from these studies will guide the development of novel obesity therapeutics targeting specific ANS dysfunction.

  1. Is decentralization good for logistics systems? Evidence on essential medicine logistics in Ghana and Guatemala.

    Science.gov (United States)

    Bossert, Thomas J; Bowser, Diana M; Amenyah, Johnnie K

    2007-03-01

    Efficient logistics systems move essential medicines down the supply chain to the service delivery point, and then to the end user. Experts on logistics systems tend to see the supply chain as requiring centralized control to be most effective. However, many health reforms have involved decentralization, which experts fear has disrupted the supply chain and made systems less effective. There is no consensus on an appropriate methodology for assessing the effectiveness of decentralization in general, and only a few studies have attempted to address decentralization of logistics systems. This paper sets out a framework and methodology of a pioneering exploratory study that examines the experiences of decentralization in two countries, Guatemala and Ghana, and presents suggestive results of how decentralization affected the performance of their logistics systems. The analytical approach assessed decentralization using the principal author's 'decision space' approach, which defines decentralization as the degree of choice that local officials have over different health system functions. In this case the approach focused on 15 different logistics functions and measured the relationship between the degree of choice and indicators of performance for each of the functions. The results of both studies indicate that less choice (i.e. more centralized) was associated with better performance for two key functions (inventory control and information systems), while more choice (i.e. more decentralized) over planning and budgeting was associated with better performance. With different systems of procurement in Ghana and Guatemala, we found that a system with some elements of procurement that are centralized (selection of firms and prices fixed by national tender) was positively related in Guatemala but negatively related in Ghana, where a system of 'cash and carry' cost recovery allowed more local choice. The authors conclude that logistics systems can be effectively

  2. Appointment reminder systems are effective but not optimal: results of a systematic review and evidence synthesis employing realist principles.

    Science.gov (United States)

    McLean, Sionnadh Mairi; Booth, Andrew; Gee, Melanie; Salway, Sarah; Cobb, Mark; Bhanbhro, Sadiq; Nancarrow, Susan A

    2016-01-01

    Missed appointments are an avoidable cost and resource inefficiency which impact upon the health of the patient and treatment outcomes. Health care services are increasingly utilizing reminder systems to manage these negative effects. This study explores the effectiveness of reminder systems for promoting attendance, cancellations, and rescheduling of appointments across all health care settings and for particular patient groups and the contextual factors which indicate that reminders are being employed sub-optimally. We used three inter-related reviews of quantitative and qualitative evidence. Firstly, using pre-existing models and theories, we developed a conceptual framework to inform our understanding of the contexts and mechanisms which influence reminder effectiveness. Secondly, we performed a review following Centre for Reviews and Dissemination guidelines to investigate the effectiveness of different methods of reminding patients to attend health service appointments. Finally, to supplement the effectiveness information, we completed a review informed by realist principles to identify factors likely to influence non-attendance behaviors and the effectiveness of reminders. We found consistent evidence that all types of reminder systems are effective at improving appointment attendance across a range of health care settings and patient populations. Reminder systems may also increase cancellation and rescheduling of unwanted appointments. "Reminder plus", which provides additional information beyond the reminder function may be more effective than simple reminders (ie, date, time, place) at reducing non-attendance at appointments in particular circumstances. We identified six areas of inefficiency which indicate that reminder systems are being used sub-optimally. Unless otherwise indicated, all patients should receive a reminder to facilitate attendance at their health care appointment. The choice of reminder system should be tailored to the individual service

  3. An Update on the Conceptual-Production Systems Model of Apraxia: Evidence from Stroke

    Science.gov (United States)

    Stamenova, Vessela; Black, Sandra E.; Roy, Eric A.

    2012-01-01

    Limb apraxia is a neurological disorder characterized by an inability to pantomime and/or imitate gestures. It is more commonly observed after left hemisphere damage (LHD), but has also been reported after right hemisphere damage (RHD). The Conceptual-Production Systems model (Roy, 1996) suggests that three systems are involved in the control of…

  4. Neural Signatures of Number Processing in Human Infants: Evidence for Two Core Systems Underlying Numerical Cognition

    Science.gov (United States)

    Hyde, Daniel C.; Spelke, Elizabeth S.

    2011-01-01

    Behavioral research suggests that two cognitive systems are at the foundations of numerical thinking: one for representing 1-3 objects in parallel and one for representing and comparing large, approximate numerical magnitudes. We tested for dissociable neural signatures of these systems in preverbal infants by recording event-related potentials…

  5. Gravitational Microlensing Evidence for a Planet Orbiting a Binary Star System

    CERN Document Server

    Bennett, D P; Becker, A C; Butler, N; Dann, J H; Kaspi, S; Leibowitz, E M; Lipkin, Yu M; Maoz, D; Mendelson, H; Peterson, B A; Quinn, J; Shemmer, O; Thomson, S; Turner, S E

    1999-01-01

    The study of extra-solar planetary systems has emerged as a new discipline of observational astronomy in the past few years with the discovery of a number of extra-solar planets. The properties of most of these extra-solar planets were not anticipated by theoretical work on the formation of planetary systems. Here we report observations and light curve modeling of gravitational microlensing event MACHO-97-BLG-41, which indicates that the lens system consists of a planet orbiting a binary star system. According to this model, the mass ratio of the binary star system is 3.8:1 and the stars are most likely to be a late K dwarf and an M dwarf with a separation of about 1.8 AU. A planet of about 3 Jupiter masses orbits this system at a distance of about 7 AU. If our interpretation of this light curve is correct, it represents the first discovery of a planet orbiting a binary star system and the first detection of a Jovian planet via the gravitational microlensing technique. It suggests that giant planets may be co...

  6. Inductive reasoning and implicit memory: evidence from intact and impaired memory systems.

    Science.gov (United States)

    Girelli, Luisa; Semenza, Carlo; Delazer, Margarete

    2004-01-01

    In this study, we modified a classic problem solving task, number series completion, in order to explore the contribution of implicit memory to inductive reasoning. Participants were required to complete number series sharing the same underlying algorithm (e.g., +2), differing in both constituent elements (e.g., 2468 versus 57911) and correct answers (e.g., 10 versus 13). In Experiment 1, reliable priming effects emerged, whether primes and targets were separated by four or ten fillers. Experiment 2 provided direct evidence that the observed facilitation arises at central stages of problem solving, namely the identification of the algorithm and its subsequent extrapolation. The observation of analogous priming effects in a severely amnesic patient strongly supports the hypothesis that the facilitation in number series completion was largely determined by implicit memory processes. These findings demonstrate that the influence of implicit processes extends to higher level cognitive domain such as induction reasoning.

  7. Electroencephalogram evidence for the activation of human mirror neuron system during the observation of intransitive shadow and line drawing actions

    Institute of Scientific and Technical Information of China (English)

    Huaping Zhu; Yaoru Sun; Fang Wang

    2013-01-01

    Previous studies have demonstrated that hand shadows may activate the motor cortex associated with the mirror neuron system in human brain. However, there is no evidence of activity of the human mirror neuron system during the observation of intransitive movements by shadows and line drawings of hands. This study examined the suppression of electroencephalography mu waves hand actions, hand shadow actions and actions made by line drawings of hands. The results showed significant desynchronization of the mu rhythm ("mu suppression") across the sensorimotor cortex (recorded at C3, Cz and C4), the frontal cortex (recorded at F3, Fz and F4) and the central and right posterior parietal cortex (recorded at Pz and P4) under all three conditions. Our experimental findings suggest that the observation of "impoverished hand actions", such as intransitive movements of shadows and line drawings of hands, is able to activate widespread cortical areas related to the putative human mirror neuron system.

  8. The Renin-Angiotensin System Modulates Inflammatory Processes in Atherosclerosis: Evidence from Basic Research and Clinical Studies

    Directory of Open Access Journals (Sweden)

    Fabrizio Montecucco

    2009-01-01

    Full Text Available Recent evidence shows that the renin-angiotensin system is a crucial player in atherosclerotic processes. The regulation of arterial blood pressure was considered from its first description of the main mechanism involved. Vasoconstriction (mediated by angiotensin II and salt and water retention (mainly due to aldosterone were classically considered as pivotal proatherosclerotic activities. However, basic research and animal studies strongly support angiotensin II as a proinflammatory mediator, which directly induces atherosclerotic plaque development and heart remodeling. Furthermore, angiotensin II induces proatherosclerotic cytokine and chemokine secretion and increases endothelial dysfunction. Accordingly, the pharmacological inhibition of the renin-angiotensin system improves prognosis of patients with cardiovascular disease even in settings of normal baseline blood pressure. In the present review, we focused on angiotensin-convertingenzyme (ACE inhibitors, angiotensin II receptor blockers (ARBs, and renin inhibitors to update the direct activities of the renin-angiotensin system in inflammatory processes governing atherosclerosis.

  9. Guidance for evidence-informed policies about health systems: rationale for and challenges of guidance development.

    Science.gov (United States)

    Bosch-Capblanch, Xavier; Lavis, John N; Lewin, Simon; Atun, Rifat; Røttingen, John-Arne; Dröschel, Daniel; Beck, Lise; Abalos, Edgardo; El-Jardali, Fadi; Gilson, Lucy; Oliver, Sandy; Wyss, Kaspar; Tugwell, Peter; Kulier, Regina; Pang, Tikki; Haines, Andy

    2012-01-01

    In the first paper in a three-part series on health systems guidance, Xavier Bosch-Capblanch and colleagues examine how guidance is currently formulated in low- and middle-income countries, and the challenges to developing such guidance.

  10. Flexible Work Systems and the Structure of Wages: Evidence from Matched Employer- Employee Data

    OpenAIRE

    Bauer, Thomas K.; Bender, Stefan

    2001-01-01

    A growing literature is concerned with the effects of flexible workplace systems or High Performance Work Organizations (HPWOs) on wages. This paper makes use of a new employer-employee-linked panel data set for Germany to examine the effects of adopting HPWOs on wages as well as on the wage structure within firms. The empirical results suggest that, depending on the particular practice, flexible workplace systems benefit employees through higher wages. HPWOs further increase within firm wage...

  11. Chemical transport in geothermal systems in Iceland: Evidence from hydrothermal alteration

    Science.gov (United States)

    Franzson, Hjalti; Zierenberg, Robert; Schiffman, Peter

    2008-06-01

    This study focuses on the chemical changes in basaltic rocks in fossil low- and high-temperature hydrothermal systems in Iceland. The method used takes into account the amount of dilution caused by vesicle and vein fillings in the rocks. The amount of dilution allows a calculation of the primary concentration of the immobile element Zr, and by multiplying the composition of the altered rock by the ratio of Zr (protolith)/Zr (altered rock) one can compute the mass addition caused by the dilution of the void fillings, and also make a direct comparison with the likely protoliths from the same areas. The samples were divided into three groups; two from Tertiary fossil high-temperature systems (Hafnarfjall, Geitafell), and the third group from a low temperature, zeolite-altered plateau basalt succession. The results show that hydrothermally altered rocks are enriched in Si, Al, Fe, Mg and Mn, and that Na, K and Ca are mobile but show either depletion or enrichment. The elements that are immobile include Zr, Y, Nb and probably Ti. The two high-temperature systems show quite similar chemical alteration trends, an observation which may apply to Icelandic fresh water high-temperature systems in general. The geochemical data show that the major changes in the altered rocks from Icelandic geothermal systems may be attributed to addition of elements during deposition of pore-filling alteration minerals. A comparison with seawater-dominated basalt-hosted hydrothermal systems shows much greater mass flux within the seawater systems, even though both systems have similar alteration assemblages. The secondary mineral assemblages seem to be controlled predominantly by the thermal stability of the alteration phases and secondarily by the composition of the hydrothermal fluids.

  12. Facilitating Ambulatory Electronic Health Record System Implementation: Evidence from a Qualitative Study

    Directory of Open Access Journals (Sweden)

    Ann Scheck McAlearney

    2013-01-01

    Full Text Available Background. Ambulatory care practices have increasing interest in leveraging the capabilities of electronic health record (EHR systems, but little information is available documenting how organizations have successfully implemented these systems. Objective. To characterize elements of successful electronic health record (EHR system implementation and to synthesize the key informants' perspectives about successful implementation practices. Methods. Key informant interviews and focus groups were conducted with a purposive sample of individuals from US healthcare organizations identified for their success with ambulatory EHR implementation. Rigorous qualitative data analyses used both deductive and inductive methods. Results. Participants identified personal and system-related barriers, at both the individual and organization levels, including poor computer skills, productivity losses, resistance to change, and EHR system failure. Implementation success was reportedly facilitated by careful planning and consistent communication throughout distinct stages of the implementation process. A significant element of successful implementation was an emphasis on optimization, both during “go-live” and, subsequently, when users had more experience with the system. Conclusion. Successful EHR implementation requires both detailed planning and clear mechanisms to deal with unforeseen or unintended consequences. Focusing on user buy-in early and including plans for optimization can facilitate greater success.

  13. Evidence for a water system transition beneath Thwaites Glacier, West Antarctica.

    Science.gov (United States)

    Schroeder, Dustin M; Blankenship, Donald D; Young, Duncan A

    2013-07-23

    Thwaites Glacier is one of the largest, most rapidly changing glaciers on Earth, and its landward-sloping bed reaches the interior of the marine West Antarctic Ice Sheet, which impounds enough ice to yield meters of sea-level rise. Marine ice sheets with landward-sloping beds have a potentially unstable configuration in which acceleration can initiate or modulate grounding-line retreat and ice loss. Subglacial water has been observed and theorized to accelerate the flow of overlying ice dependent on whether it is hydrologically distributed or concentrated. However, the subglacial water systems of Thwaites Glacier and their control on ice flow have not been characterized by geophysical analysis. The only practical means of observing these water systems is airborne ice-penetrating radar, but existing radar analysis approaches cannot discriminate between their dynamically critical states. We use the angular distribution of energy in radar bed echoes to characterize both the extent and hydrologic state of subglacial water systems across Thwaites Glacier. We validate this approach with radar imaging, showing that substantial water volumes are ponding in a system of distributed canals upstream of a bedrock ridge that is breached and bordered by a system of concentrated channels. The transition between these systems occurs with increasing surface slope, melt-water flux, and basal shear stress. This indicates a feedback between the subglacial water system and overlying ice dynamics, which raises the possibility that subglacial water could trigger or facilitate a grounding-line retreat in Thwaites Glacier capable of spreading into the interior of the West Antarctic Ice Sheet.

  14. No evidence for mirror system dysfunction in schizophrenia from a multimodal TMS/EEG study.

    Science.gov (United States)

    Andrews, Sophie C; Enticott, Peter G; Hoy, Kate E; Thomson, Richard H; Fitzgerald, Paul B

    2015-08-30

    Dysfunctional mirror neuron systems have been proposed to contribute to the social cognitive deficits observed in schizophrenia. A few studies have explored mirror systems in schizophrenia using various techniques such as TMS (levels of motor resonance) or EEG (levels of mu suppression), with mixed results. This study aimed to use a novel multimodal approach (i.e. concurrent TMS and EEG) to further investigate mirror systems and social cognition in schizophrenia. Nineteen individuals with schizophrenia or schizoaffective disorder and 19 healthy controls participated. Single-pulse TMS was applied to M1 during the observation of hand movements designed to elicit mirror system activity. Single EEG electrodes (C3, CZ, C4) recorded brain activity. Participants also completed facial affect recognition and theory of mind tasks. The schizophrenia group showed significant deficits in facial affect recognition and higher level theory of mind compared to healthy controls. A significant positive relationship was revealed between mu suppression and motor resonance for the overall sample, indicating concurrent validity of these measures. Levels of mu suppression and motor resonance were not significantly different between groups. These findings indicate that in stable outpatients with schizophrenia, mirror system functioning is intact, and therefore their social cognitive difficulties may be caused by alternative pathophysiology.

  15. Genetic evidence confirms polygamous mating system in a crustacean parasite with multiple hosts.

    Directory of Open Access Journals (Sweden)

    Quentin Jossart

    Full Text Available Mating systems are diverse in animals, notably in crustaceans, but can be inferred from a limited set of parameters. Baeza and Thiel (2007 proposed a model predicting mating systems of symbiotic crustaceans with three host characteristics and the risk of predation. These authors proposed five mating systems, ranging from monogamy to polygynandry (where multiple mating occurs for both genders. Using microsatellite loci, we tested the putatively mating system of the ectoparasite crab Dissodactylus primitivus. We determined the mating frequencies of males and females, parentage assignment (COLONY & GERUD software as well as the contents of female spermathecae. Our results are globally consistent with the model of Baeza and Thiel and showed, together with previous aquarium experiments, that this ectoparasite evolved a polygamous mating system where males and females move between hosts for mate search. Parentage analyses revealed that polyandry is frequent and concerns more than 60% of clutches, with clutches being fertilized by up to 6 different fathers. Polygyny is supported by the detection of eight males having sired two different broods. We also detected a significant paternity skew in 92% of the multipaternal broods. Moreover, this skew is probably higher than the estimation from the brood because additional alleles were detected in most of spermathecae. This high skew could be explained by several factors as sperm competition or cryptic female choice. Our genetic data, combined with previous anatomic analyses, provide consistent arguments to suggest sperm precedence in D. primitivus.

  16. Does the Financial System Promote Sustainable Development? Evidence from Eastern European Countries

    Directory of Open Access Journals (Sweden)

    Ioana Andrada Moldovan (Gavril

    2015-06-01

    Full Text Available This article aims at analyzing the relationship between sustainable development and the financial system, mainly focusing on the role that the financial system plays within the process of sustainable development. Theoretically, the financial system could be a very important factor to promote sustainable development, as it could foster economic growth and development, efficient resource allocation, the protection of the environment and also social responsibility. Using panel data econometrical analysis, we tested for correlations between indicators of the financial system and indicators of sustainable development in five developing Eastern European countries. We found weak or no correlation between financial indicators and sustainable development indicators. This might be explained by several facts. First, the financial systems of these five developing countries are not highly developed, so that they do not have a high capacity to foster economic growth and development. Second, even if this was the case, promoting sustainable development requires a lot more than fostering economic growth and is not a question of whether the financial companies can promote sustainability, but whether they are interested in promoting it. Even though financial companies have embraced the sustainability agenda, they haven`t done much to change their short-term orientation to profit and to shift to long-run strategies in favor of sustainable development. 

  17. Regulation in the face of uncertainty: the evidence on electronic nicotine delivery systems (e-cigarettes).

    Science.gov (United States)

    Farsalinos, Konstantinos E; Le Houezec, Jacques

    2015-01-01

    Tobacco smoking is the largest single preventable cause of many chronic diseases and death. Effective treatments exist; however, few smokers use them and most try to quit by themselves. Most of the tobacco cigarette's toxicity is related to the combustion process. Models of harm reduction applied to tobacco suggest that switching from inhalation of combustible products to a noncombustible nicotine delivery product would likely result in a vast reduction in tobacco-related death and illness. Currently available evidence raises no doubt that electronic cigarettes (e-cigs) are by far less harmful than smoking (although probably not absolutely safe) and have the potential to be the most effective tobacco harm reduction products due to their unique property of resembling smoking and providing satisfaction to the user. A lot of controversy is surrounding e-cigs and their regulation, much of which is based on the precautionary principle. Although monitoring and further research is definitely needed, the arguments used to implement severe restrictions or bans are mostly hypothetical, weakly supported by evidence, and, in some cases, derived from mispresentation or misinterpretation of the study findings. Regulators should keep in mind that the target population is smokers who want to reduce or quit their deadly tobacco consumption. To achieve this goal, smokers should be honestly informed on the relative harmfulness of the different products. E-cigs are not tobacco products and are not used as medications. For this reason, a specific regulatory scheme is needed, separate from tobacco or medicinal products regulation. Regulation should implement specific quality criteria for products, rules for the exclusion of chemicals of reasonable concern, and appropriate testing for possible contaminants. Additionally, manufacturing standards derived from the food industry should be implemented and adjusted for specific conditions related to e-cigs. Finding the appropriate balance

  18. Evidence for production of oxidizing radicals by the particulate O-2-forming system from human neutrophils.

    Science.gov (United States)

    Tauber, A I; Gabig, T G; Babior, B M

    1979-04-01

    The particulate O-2-forming system from human neutrophils was found to oxidize methional and 2-keto-4-methylthiobutyric acid (KMB) to ethylene, indicating the formation by this system of strongly oxidizing radicals. Conforming this interpretation was the observation that ethylene production was inhibited by the radical scavengers benzoate, ethanol, and mannitol. Ethylene production was also sharply reduced by superoxide dismutase, implicatin O-2 as a precursor of oxidizing radicals. In our system catalase only partially inhibited ethylene generation from either methional or KMB, suggesting that oxidizing radicals are generated at least in part by the reacton of O-2 with compounds other than H2O2. We propose that in neutrophils oxidizing radicals are formed in a reaction between O-2 and a peroxide according to the following equation: O-2 + ROOH leads to RO . + OH- + O2, in which ROOH may be hydrogen peroxide, an alkyl peroxide, or an acyl peroxide (i.e., a peroxy acid).

  19. Motivators, Barriers and Concerns in Adoption of Electronic Filing System: Survey Evidence from Malaysian Professional Accountants

    Directory of Open Access Journals (Sweden)

    Ming-Ling Lai

    2010-01-01

    Full Text Available Problem statement: Worldwide, electronic filing (e-filing system and its' adoption has attracted much attention, however, scholarly study on accounting professionals' acceptance of e-filing system is scant. Approach: This study aimed (i to examine factors that motivated professional accountants to use e-filing (ii to solicit their usage experience and (iii to assess the barriers to adoption and other compliance considerations. The questionnaire survey was administered on 700 professionals from tax practice and commercial sectors who attended "Budget 2008" Tax Seminars, organized by the Malaysian Institute of Accountants in Peninsular Malaysia. In total, 456 usable responses from accounting and tax professionals were collected and analyzed. Results: The survey found out of 456 respondents, just 23.7% had used e-filing in 2007 to file personal tax return forms. Majority of the e-filers opted to use e-filing for the sake of convenience (55.8%, in faith to get faster tax refund (16.8% and speed of filing (15.9%. For those who did not use e-filing, the key impediments were concerned over the security and did not trust of e-filing system. Some (4.8% were unable to access to the e-filing website. Overall, just 26.1% of the professionals surveyed had confidence in the IRBM in managing the e-filing system successfully. Majority (41.2% thought that 'speedy tax refund' to be the most desirable incentive to motivate individuals to use e-filing. Conclusion: As the IRBM is counting on professional accountants to promote the usage of e-filing system, this study provided important insights to the IRBM to developing marketing and business strategies to motivate professional accountant in business to use e-filing in order to accelerate the diffusion of e-filing system in a developing country like Malaysia.

  20. Dynamics of an Interacting Particle System: Evidence of Critical Slowing Down

    DEFF Research Database (Denmark)

    Djurberg, Claes; Svedlindh, Peter; Nordblad, Per;

    1997-01-01

    The dynamics of a magnetic particle system consisting of ultrafine Fe-C particles of monodisperse nature has been investigated in a large time window, 10(-9)-10(4) s, using Mossbauer spectroscopy, ac susceptibility, and zero field cooled magnetic relaxation measurements. By studying two samples...... from the same dilution series, with concentrations of 5 and 6 x 10(-3) vol%, respectively, it has been found that dipole-dipole interaction increases the characteristic relaxation time of the particle system at all temperatures investigated. The results for the most concentrated particle assembly...

  1. Impact of Basel Accord on Banking System(Evidence from Islamic Banks of Pakistan)

    OpenAIRE

    Muhammad Mehtab Azeem; Akin Marsap; Cigdem Ozari

    2015-01-01

    Banks and bank regulatory authorities are vital players for the stability of economy and financial system in potential way. Basel III and its related to capital¡¯s requirement obligations have been effective useful tool for the banking system. Since, this is tough job for the bankers to maintain the liquidity for hedging the future risk but it also been expensive for bankers to keep the extra capital and become more liquid since this discourage the provision of loans but promote the credit ra...

  2. Numerical evidence of drift term in two-dimensional point vortex system at negative absolute temperature

    CERN Document Server

    Yatsuyanagi, Yuichi

    2016-01-01

    The drift term appearing in an anaylitically obtained kinetic equation for a point vortex system is evidenced numerically. It is revealed that the local temperature in a region where the vortices are frequently transported by the diffusion and the drift terms characterizes system temperature and its sign is definitely negative. Simulation results clearly show a ransport process of the vortices by the diffusion term (outside the clumps) and the drift term (inside the clumps), which gives a key mechanism of the self-organization, i.e., condensation of the same-sign vortices.

  3. Ontology supported system for searching evidence of wild animals trafficking in social network posts

    Directory of Open Access Journals (Sweden)

    Rafael da Silva Carrasco

    2014-04-01

    Full Text Available O comércio ilegal de animais silvestres é uma das atividades criminais mais lucrativas da atualidade. No Brasil, a grande variedade de fauna nativa tem alimentado o mercado ilegal, o que gera sérias implicações ambientais e sociais. A luta contra o comércio ilegal de animais silvestres é crucial para ajudar a proteger os recursos naturais e evitar a disseminação de outras formas de crime. Esse tipo de comércio ilegal usa cada vez mais, a internet para realizar suas atividades. A fim de combater tal crime, um sistema automático de monitorização é essencial. No entanto, para realizar essa tarefa de forma eficaz, o sistema deve ser capaz de analisar as mensagens trocadas durante essa prática. Para isso, é necessário o conhecimento dos conceitos e relações que ocorrem nesse domínio. Este artigo apresenta um sistema multiagente apoiado por ontologia de domínio e frames semânticos para buscar evidências de comércio ilegal de animais silvestres. No artigo, é mostrado como o sistema pode ser usado na tarefa de rastreamento do comércio ilegal de animais silvestres, além de apresentar os resultados da aplicação do sistema em um pequeno corpus.

  4. Neuropsychological deficits in Lyme disease patients with and without other evidence of central nervous system pathology.

    Science.gov (United States)

    Kaplan, R F; Jones-Woodward, L; Workman, K; Steere, A C; Logigian, E L; Meadows, M E

    1999-01-01

    A small percentage of Lyme patients develop mild to moderate encephalopathic symptoms months to years after diagnosis and treatment. Their symptoms typically include fatigue, memory loss, sleep disturbance, and depression. However, the etiology of this syndrome remains controversial. It is generally thought that Lyme patients with abnormal cerebral spinal fluid (CSF) have a neurological basis to their illness. To further examine this question, we compared Lyme patients with evidence of abnormal CSF, intrathecal antibody to Borrelia burgdorferi, elevated protein, or a positive polymerase chain reaction for B. burgdorferi DNA (n = 14); Lyme patients with normal CSF (n = 18); and healthy controls (n = 15) on a battery of neuropsychological and personality tests. Although both Lyme groups reported memory problems, only the Lyme group with abnormal CSF had measurable memory deficits. Both Lyme groups had higher depression scores than the normal control group, although depression was not correlated with memory scores. It appears that Lyme patients with abnormal CSF may have a neurological basis to their illness, whereas affective symptoms, common to many chronic disorders, may predispose other Lyme patients to the perception of cognitive dysfunction.

  5. Chlorogenic acid-arabinose hybrid domains in coffee melanoidins: Evidences from a model system.

    Science.gov (United States)

    Moreira, Ana S P; Coimbra, Manuel A; Nunes, Fernando M; Passos, Cláudia P; Santos, Sónia A O; Silvestre, Armando J D; Silva, André M N; Rangel, Maria; Domingues, M Rosário M

    2015-10-15

    Arabinose from arabinogalactan side chains was hypothesized as a possible binding site for chlorogenic acids in coffee melanoidins. To investigate this hypothesis, a mixture of 5-O-caffeoylquinic acid (5-CQA), the most abundant chlorogenic acid in green coffee beans, and (α1 → 5)-L-arabinotriose, structurally related to arabinogalactan side chains, was submitted to dry thermal treatments. The compounds formed during thermal processing were identified by electrospray ionization mass spectrometry (ESI-MS) and characterized by tandem MS (ESI-MS(n)). Compounds composed by one or two CQAs covalently linked with pentose (Pent) residues (1-12) were identified, along with compounds bearing a sugar moiety but composed exclusively by the quinic or caffeic acid moiety of CQAs. The presence of isomers was demonstrated by liquid chromatography online coupled to ESI-MS and ESI-MS(n). Pent1-2CQA were identified in coffee samples. These results give evidence for a diversity of chlorogenic acid-arabinose hybrids formed during roasting, opening new perspectives for their identification in melanoidin structures.

  6. Primary immune system responders to nucleus pulposus cells: evidence for immune response in disc herniation

    Directory of Open Access Journals (Sweden)

    K Murai

    2010-01-01

    Full Text Available Although intervertebral disc herniation and associated sciatica is a common disease, its molecular pathogenesis is not well understood. Immune responses are thought to be involved. This study provides direct evidence that even non-degenerated nucleus pulposus (NP cells elicit immune responses. An in vitro colony forming inhibition assay demonstrated the suppressive effects of autologous spleen cells on NP cells and an in vitro cytotoxicity assay showed the positive cytotoxic effects of natural killer (NK cells and macrophages on NP cells. Non-degenerated rat NP tissues transplanted into wild type rats and immune-deficient mice demonstrated a significantly higher NP cell survival rate in immune-deficient mice. Immunohistochemical staining showed the presence of macrophages and NK cells in the transplanted NP tissues. These results suggest that even non-degenerated autologous NP cells are recognized by macrophages and NK cells, which may have an immunological function in the early phase of disc herniation. These findings contribute to understanding resorption and the inflammatory reaction to disc herniation.

  7. [Medicinal cannabis for diseases of the nervous system: no convincing evidence of effectiveness].

    Science.gov (United States)

    Killestein, J; Bet, P M; van Loenen, A C; Polman, C H

    2004-11-27

    --In 1996, the Netherlands Health Council issued a negative recommendation regarding the use of medication on the basis of cannabis (marihuana). However, interest in medicinal cannabis has certainly not waned since. --The neurological diseases for which cannabis could presently be used therapeutically are: multiple sclerosis, chronic (neuropathic) pain and the syndrome of Gilles de la Tourette. --Since September 2003, the Dutch Ministry of Health, Welfare and Sport delivers medicinal cannabis to Dutch pharmacies, so that now for the first time, medicinal cannabis can be given to patients on a prescription basis within the framework of the Opium Law. The result of this is that doctors and patients now assume that this is a medication for which the efficacy and safety have been established. --The question arises whether new scientific data have become available since 1996 that provide scientific support for the current Governmental policy. --In a recent clinical trial that has aroused much discussion, patients with multiple sclerosis and problematic spasticity were treated with oral cannabis or a placebo. There was no significant effect of treatment on the primary outcome measure, i.e. objectively determined spasticity. Nevertheless, it was concluded that the mobility was improved and that the pain was subjectively decreased. --Until now, convincing scientific evidence that cannabinoids are effective in neurological conditions is still lacking. --However, it is also not possible to conclude definitely that cannabinoids are ineffective; still, this is no basis for official stimulation of their use.

  8. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

    Directory of Open Access Journals (Sweden)

    Lesley Jones

    Full Text Available BACKGROUND: Late Onset Alzheimer's disease (LOAD is the leading cause of dementia. Recent large genome-wide association studies (GWAS identified the first strongly supported LOAD susceptibility genes since the discovery of the involvement of APOE in the early 1990s. We have now exploited these GWAS datasets to uncover key LOAD pathophysiological processes. METHODOLOGY: We applied a recently developed tool for mining GWAS data for biologically meaningful information to a LOAD GWAS dataset. The principal findings were then tested in an independent GWAS dataset. PRINCIPAL FINDINGS: We found a significant overrepresentation of association signals in pathways related to cholesterol metabolism and the immune response in both of the two largest genome-wide association studies for LOAD. SIGNIFICANCE: Processes related to cholesterol metabolism and the innate immune response have previously been implicated by pathological and epidemiological studies of Alzheimer's disease, but it has been unclear whether those findings reflected primary aetiological events or consequences of the disease process. Our independent evidence from two large studies now demonstrates that these processes are aetiologically relevant, and suggests that they may be suitable targets for novel and existing therapeutic approaches.

  9. Nitrergic system and plasmatic methylarginines: Evidence of their role in the perinatal programming of cardiovascular diseases.

    Science.gov (United States)

    Bassareo, Pier Paolo; Mussap, Michele; Bassareo, Valentina; Flore, Giovanna; Mercuro, Giuseppe

    2015-12-01

    Atherosclerosis, in turn preceded by endothelial dysfunction, underlies a series of important cardiovascular diseases. Reduced bioavailability of endothelial nitric oxide, by increasing vascular tone and promoting platelet aggregation, leukocyte adhesion, and smooth muscle cell proliferation, plays a key role in the onset of the majority of cardiovascular diseases. In addition, high blood levels of asymmetric dimethylarginine, a potent inhibitor of nitric oxide synthesis, are associated with future development of adverse cardiovascular events and cardiac death. Recent reports have demonstrated that another methylarginine, i.e., symmetric dimethylarginine, is also involved in the onset of endothelial dysfunction and hypertension. Almost a decade ago, prematurity at birth and intrauterine growth retardation were first associated with a potential negative influence on the cardiovascular apparatus, thus constituting risk factors or leading to early onset of cardiovascular diseases. This condition is referred to as cardiovascular perinatal programming. Accordingly, cardiovascular morbidity and mortality are higher among former preterm adults than in those born at term. The aim of this paper was to undertake a comprehensive literature review focusing on cellular and biochemical mechanisms resulting in both reduced nitric oxide bioavailability and increased methylarginine levels in subjects born preterm. Evidence of the involvement of these compounds in the perinatal programming of cardiovascular risk are also discussed.

  10. Maltreatment, Academic Difficulty, and Systems-Involved Youth: Current Evidence and Opportunities

    Science.gov (United States)

    Stone, Susan; Zibulsky, Jamie

    2015-01-01

    Youth involved in child-serving systems of care (e.g., child welfare and juvenile justice) often exhibit specific academic performance problems. The magnitude of academic risk among these students is a serious concern given that school attachment, performance, and attainment closely relate to indicators of well-being across the lifespan. It is…

  11. Impact of product platforms on lean production systems : evidence from industrial machinery manufacturing

    NARCIS (Netherlands)

    Alblas, A.A.; Wortmann, J.C.

    2012-01-01

    The present study describes the effects of product platform changes on lean production systems. Current research into product platforms focuses mostly on the development stage. However, although the initial development of platforms is an important issue, product platforms often evolve during later s

  12. Reassessing the WIC Effect: Evidence from the Pregnancy Nutrition Surveillance System

    Science.gov (United States)

    Joyce, Ted; Racine, Andrew; Yunzal-Butler, Cristina

    2008-01-01

    Recent analyses differ on how effective the Special Supplemental Nutrition Program for Women, Infants and Children (WIC) is at improving infant health. We use data from nine states that participate in the Pregnancy Nutrition Surveillance System to address limitations in previous work. With information on the mother's timing of WIC enrollment, we…

  13. The Environmental Belief Systems of Organic and Conventional Farmers: Evidence from Central-Southern England

    Science.gov (United States)

    Kings, David; Ilbery, Brian

    2010-01-01

    Little comparative work has been conducted on the environmental belief systems and behaviours of conventional and organic farmers, especially in relation to farming culture, the environment and lowland farmland avifauna. Adopting a modified behavioural approach, this paper analyses the ways in which the environmental attitudes and understandings…

  14. Introducing a Computer Algebra System in Mathematics Education--Empirical Evidence from Germany

    Science.gov (United States)

    Schmidt, Karsten; Kohler, Anke; Moldenhauer, Wolfgang

    2009-01-01

    This paper reports on the effects the use of a pocket calculator-based computer algebra system (CAS) has on the performance in mathematics of grade 11 students in Germany. A project started at 8 of about one hundred upper secondary schools in the federal state of Thuringia in 1999; 3 years later the former restrictions on the use of technology in…

  15. Evidence of Nervous System Sensitization in Commonly Presenting and Persistent Painful Tendinopathies : A Systematic Review

    NARCIS (Netherlands)

    Plinsinga, Melanie L.; Brink, Michel S.; Vicenzino, Bill; Van Wilgen, C. Paul

    2015-01-01

    STUDY DESIGN: Systematic review. OBJECTIVES: To elucidate if there is sensitization of the nervous system in those with persistent rotator cuff (shoulder), lateral elbow, patellar, and Achilles tendinopathies. BACKGROUND: Tendinopathy can be difficult to treat, and persistent intractable pain and dy

  16. Evidences of Polymorphism Associated with Circadian System and Risk of Pathologies: A Review of the Literature

    Directory of Open Access Journals (Sweden)

    F. J. Valenzuela

    2016-01-01

    Full Text Available The circadian system is a supraphysiological system that modulates different biological functions such as metabolism, sleep-wake, cellular proliferation, and body temperature. Different chronodisruptors have been identified, such as shift work, feeding time, long days, and stress. The environmental changes and our modern lifestyle can alter the circadian system and increase the risk of developing pathologies such as cancer, preeclampsia, diabetes, and mood disorder. This system is organized by transcriptional/tranductional feedback loops of clock genes Clock, Bmal1, Per1–3, and Cry1-2. How molecular components of the clock are able to influence the development of diseases and their risk relation with genetic components of polymorphism of clock genes is unknown. This research describes different genetic variations in the population and how these are associated with risk of cancer, metabolic diseases such as diabetes, obesity, and dyslipidemias, and also mood disorders such as depression, bipolar disease, excessive alcohol intake, and infertility. Finally, these findings will need to be implemented and evaluated at the level of genetic interaction and how the environment factors trigger the expression of these pathologies will be examined.

  17. Effects of Job Accessibility Improved by Public Transport System: Natural Experimental Evidence from the Copenhagen Metro

    DEFF Research Database (Denmark)

    Pons Rotger, Gabriel Angel; Nielsen, Thomas Alexander Sick

    2015-01-01

    and Metro system resulting from the construction of a new terminal Metro station connecting southern townships to Copenhagen city centre. The results show that public transport based job accessibility has a positive and permanent effect on individual earnings. The increase in earnings is associated...

  18. Effects of Job Accessibility Improved by Public Transport System: Natural Experimental Evidence from the Copenhagen Metro

    DEFF Research Database (Denmark)

    Rotger, Gabriel Pons; Sick Nielsen, Thomas

    2015-01-01

    and Metro system due to the construction of a new terminal Metro station connecting southern townships to the city centre of Copenhagen. The results show that public transport based job accessibility has a positive and permanent effect on individual earnings. The increase in earnings is associated...

  19. Multiple Systems for Cognitive Control: Evidence from a Hybrid Prime-Simon Task

    Science.gov (United States)

    Schlaghecken, Friederike; Refaat, Malik; Maylor, Elizabeth A.

    2011-01-01

    Cognitive control resolves conflicts between appropriate and inappropriate response tendencies. Is this achieved by a unitary all-purpose conflict control system, or do independent subsystems deal with different aspects of conflicting information? In a fully factorial hybrid prime-Simon task, participants responded to the identity of targets…

  20. Organizational Learning, Change Process, and Evolution of Management Systems: Empirical Evidence from the Basque Region

    Science.gov (United States)

    Aramburu, Nekane; Saenz, Josune; Rivera, Olga

    2006-01-01

    Purpose: The purpose of this research is to analyze the relationship between the organizational learning capacity of manufacturing companies in the Spanish Basque Region and their management systems. Design/methodology/approach: To this end, an ad hoc questionnaire was devised and addressed to the Chief Executive Officers of a representative…

  1. Evidences of Polymorphism Associated with Circadian System and Risk of Pathologies: A Review of the Literature

    Science.gov (United States)

    Valenzuela, F. J.; Vera, J.; Venegas, C.; Muñoz, S.; Oyarce, S.; Muñoz, K.; Lagunas, C.

    2016-01-01

    The circadian system is a supraphysiological system that modulates different biological functions such as metabolism, sleep-wake, cellular proliferation, and body temperature. Different chronodisruptors have been identified, such as shift work, feeding time, long days, and stress. The environmental changes and our modern lifestyle can alter the circadian system and increase the risk of developing pathologies such as cancer, preeclampsia, diabetes, and mood disorder. This system is organized by transcriptional/tranductional feedback loops of clock genes Clock, Bmal1, Per1–3, and Cry1-2. How molecular components of the clock are able to influence the development of diseases and their risk relation with genetic components of polymorphism of clock genes is unknown. This research describes different genetic variations in the population and how these are associated with risk of cancer, metabolic diseases such as diabetes, obesity, and dyslipidemias, and also mood disorders such as depression, bipolar disease, excessive alcohol intake, and infertility. Finally, these findings will need to be implemented and evaluated at the level of genetic interaction and how the environment factors trigger the expression of these pathologies will be examined. PMID:27313610

  2. Guidance for evidence-informed policies about health systems: rationale for and challenges of guidance development.

    Directory of Open Access Journals (Sweden)

    Xavier Bosch-Capblanch

    Full Text Available In the first paper in a three-part series on health systems guidance, Xavier Bosch-Capblanch and colleagues examine how guidance is currently formulated in low- and middle-income countries, and the challenges to developing such guidance.

  3. Study on Evidence Grading System in Evidence-based Clinical Practice Guidelines of Traditional Chinese Medicine%建立循证中医临床实践指南证据分级体系的构想

    Institute of Scientific and Technical Information of China (English)

    汪受传; 陈争光; 徐珊; 赵霞; 虞舜

    2013-01-01

    This article explained that the evidence grading system occupied an important position in the evidence-based clinical practice guidelines. Through the comparative analysis on characteristics of clinical evidences between traditional Chinese medicine (TCM) and modern medicine, different possible establishment ideas of evidence grading system in TCM evidence-based clinical practice guidelines were proposed . The design for evidence grading standard of Chinese medical literature which reflected the academic characteristics of TCM was suggested.%通过阐述证据分级体系在循证临床实践指南的重要地位,中医学和西医学临床证据特点的对比分析,评析了建立循证中医临床实践指南证据分级体系的各种设想,提出了具有本学科学术特点的中医文献证据分级标准。

  4. The health systems' priority setting criteria for selecting health technologies: A systematic review of the current evidence

    Science.gov (United States)

    Mobinizadeh, Mohammadreza; Raeissi, Pouran; Nasiripour, Amir Ashkan; Olyaeemanesh, Alireza; Tabibi, Seyed Jamaleddin

    2016-01-01

    Background: In the recent years, using health technologies to diagnose and treat diseases has had a considerable and accelerated growth. The proper use of these technologies may considerably help in the diagnosis and treatment of different diseases. On the other hand, unlimited and unrestricted entry of these technologies may result in induced demand by service providers. The aim of this study was to determine the appropriate criteria used in health technologies priority-setting models in the world. Methods: Using MESH and free text, we sought and retrieved the relevant articles from the most appropriate medical databases (the Cochrane Library, PubMed and Scopus) through three separate search strategies up to March 2015. The inclusion criteria were as follows: 1) Studies with specific criteria; 2) Articles written in English; 3) Those articles conducted in compliance with priority setting of health technologies. Data were analyzed qualitatively using a thematic synthesis technique. Results: After screening the retrieved papers via PRISMA framework, from the 7,012 papers, 40 studies were included in the final phase. Criteria for selecting health technologies (in pre assessment and in the assessment phase) were categorized into six main themes: 1) Health outcomes; 2) Disease and target population; 3) Technology alternatives; 4) Economic aspects; 5) Evidence; 6) and other factors. "Health effects/benefits" had the maximum frequency in health outcomes (8 studies); "disease severity" had the maximum frequency in disease and target population (12 studies); "the number of alternatives" had the maximum frequency in alternatives (2 studies); "cost-effectiveness" had the maximum frequency in economic aspects (15 studies); "quality of evidence" had the maximum frequency in evidence (4 studies); and "issues concerning the health system" had the maximum frequency in other factors (10 studies). Conclusion: The results revealed an increase in the number of studies on health

  5. Regulation in the face of uncertainty: the evidence on electronic nicotine delivery systems (e-cigarettes

    Directory of Open Access Journals (Sweden)

    Farsalinos KE

    2015-09-01

    Full Text Available Konstantinos E Farsalinos,1,2 Jacques Le Houezec3,4 1Department of Cardiology, Onassis Cardiac Surgery Center, Kallithea, 2Department of Pharmacy, University of Patras, Patras, Greece; 3Division of Epidemiology and Public Health, UK Centre for Tobacco and Alcohol Studies, University of Nottingham, Nottingham, England, UK; 4Addiction Research Unit, INSERM 1178 (Mental and Public Health, Paris, France Abstract: Tobacco smoking is the largest single preventable cause of many chronic diseases and death. Effective treatments exist; however, few smokers use them and most try to quit by themselves. Most of the tobacco cigarette's toxicity is related to the combustion process. Models of harm reduction applied to tobacco suggest that switching from inhalation of combustible products to a noncombustible nicotine delivery product would likely result in a vast reduction in tobacco-related death and illness. Currently available evidence raises no doubt that electronic cigarettes (e-cigs are by far less harmful than smoking (although probably not absolutely safe and have the potential to be the most effective tobacco harm reduction products due to their unique property of resembling smoking and providing satisfaction to the user. A lot of controversy is surrounding e-cigs and their regulation, much of which is based on the precautionary principle. Although monitoring and further research is definitely needed, the arguments used to implement severe restrictions or bans are mostly hypothetical, weakly supported by evidence, and, in some cases, derived from mispresentation or misinterpretation of the study findings. Regulators should keep in mind that the target population is smokers who want to reduce or quit their deadly tobacco consumption. To achieve this goal, smokers should be honestly informed on the relative harmfulness of the different products. E-cigs are not tobacco products and are not used as medications. For this reason, a specific regulatory

  6. Distinct silicon and germanium pathways in the soil-plant system: Evidence from banana and horsetail

    Science.gov (United States)

    Delvigne, C.; Opfergelt, S.; Cardinal, D.; Delvaux, B.; André, L.

    2009-06-01

    Plants strongly impact the continental silicon cycle by taking up Si and precipitating opal phytoliths which are recycled into the soil. Studying Ge incorporation, a chemical analog of Si, relative to Si may provide a useful tracer of Si pathways. However, Ge uptake and transport through plants and the impact on Ge/Si of phytoliths remain poorly understood. Here, we report Ge uptake and accumulation and Ge/Si fractionation in all plant parts and solutions from: (1) hydroponic banana, (2) in situ sampled banana, and (3) horsetails. We further combine these data with δ29Si from banana plants. Our data reconcile opposite conclusions drawn from previous studies on Ge uptake and pathways. No discrimination of Ge occurred at the root-solution interface. Banana and horsetails were shown to accumulate Ge in roots: a previous study provided evidence of low Ge/Si ratios in root phytoliths which contrasts with high bulk Ge/Si ratios in roots we report here. This suggests that Ge is organically trapped in roots. Consequently, shoots display lower Ge/Si ratios, without fractionation between shoot parts since Ge would follow transpiration stream as silicon, and is not discriminated between shoot parts. This contrasts with the two-step discrimination against heavy Si isotopes, at the root-solution interface, and then within the shoots. The soil composition (clays versus Fe oxides) has a leading role on the Ge/Si signatures of plants which may in turn impact on the Si and Ge fluxes to the global ocean.

  7. Pioglitazone (Actos) and bladder cancer: Legal system triumphs over the evidence.

    Science.gov (United States)

    Davidson, Mayer B

    2016-08-01

    In preclinical studies, pioglitazone was associated with bladder cancer in male rats (but not in female rats, mice dogs or monkeys). Because of this association, the Federal Drug Administration requested a large 10year epidemiological study to evaluate whether there was an association between bladder cancer and exposure to pioglitazone in patients. A 5-year interim report published in 2011 showed no significant association between ever vs never exposure to the drug but a significant association in patients exposed to pioglitazone for >2years. Importantly, the final 10year report did not confirm the 5year interim report finding no association between bladder cancer and pioglitazone, even after >4years of exposure to the drug. However, as would be expected, following the 5-year interim report, many epidemiological studies were carried out and civil litigation lawsuits began to be filed. Of the 23 epidemiological studies that have been published to date, 18 showed no association between bladder cancer and pioglitazone (5 with a combination of rosiglitazone and pioglitazone). Of the five that did show a significant association with pioglitazone, three could not be confirmed in the same population and in one of them there were significantly more risk factors for bladder cancer in the patients exposed to pioglitazone. In the fourth one, a significant association became non-significant when patients >79years were included. In the fifth one, detection bias was a major flaw. Currently, >11,000 legal cases have been filed, many of which claim emotional distress due to the fear of bladder cancer. To limit their legal costs, the pharmaceutical company has established a 2.4 billion dollar settlement pool. So much for evidence-based medicine.

  8. Renin-angiotensin system as a potential therapeutic target in stroke and retinopathy: experimental and clinical evidence.

    Science.gov (United States)

    Fouda, Abdelrahman Y; Artham, Sandeep; El-Remessy, Azza B; Fagan, Susan C

    2016-02-01

    As our knowledge expands, it is now clear that the renin-angiotensin (Ang) system (RAS) mediates functions other than regulating blood pressure (BP). The RAS plays a central role in the pathophysiology of different neurovascular unit disorders including stroke and retinopathy. Moreover, the beneficial actions of RAS modulation in brain and retina have been documented in experimental research, but not yet exploited clinically. The RAS is a complex system with distinct yet interconnected components. Understanding the different RAS components and their functions under brain and retinal pathological conditions is crucial to reap their benefits. The aim of the present review is to provide an experimental and clinical update on the role of RAS in the pathophysiology and treatment of stroke and retinopathy. Combining the evidence from both these disorders allows a unique opportunity to move both fields forward.

  9. What role can information play in improved equity in Pakistan's irrigation system? Evidence from an experimental game in Punjab

    Directory of Open Access Journals (Sweden)

    Andrew Reid. Bell

    2015-03-01

    Full Text Available The Indus Basin Irrigation System suffers significant inequity in access to surface water across its millions of users. Information, i.e., monitoring and reporting of water availability, may be of value in improving conditions across the basin, and we investigated this via an experimental game of water distribution in Punjab, Pakistan. We found evidence that flow information allowed players to take more effective action to target overuse, and that overall activities that might bring social disapproval were reduced with information. However, we did not find any overall improvement in equity across the system, suggesting that information on its own might not be sufficient to lead to better water distribution among irrigators.

  10. FMRI evidence for the involvement of the procedural memory system in morphological processing of a second language.

    Directory of Open Access Journals (Sweden)

    Christos Pliatsikas

    Full Text Available Behavioural evidence suggests that English regular past tense forms are automatically decomposed into their stem and affix (played  = play+ed based on an implicit linguistic rule, which does not apply to the idiosyncratically formed irregular forms (kept. Additionally, regular, but not irregular inflections, are thought to be processed through the procedural memory system (left inferior frontal gyrus, basal ganglia, cerebellum. It has been suggested that this distinction does not to apply to second language (L2 learners of English; however, this has not been tested at the brain level. This fMRI study used a masked-priming task with regular and irregular prime-target pairs (played-play/kept-keep to investigate morphological processing in native and highly proficient late L2 English speakers. No between-groups differences were revealed. Compared to irregular pairs, regular pairs activated the pars opercularis, bilateral caudate nucleus and the right cerebellum, which are part of the procedural memory network and have been connected with the processing of morphologically complex forms. Our study is the first to provide evidence for native-like involvement of the procedural memory system in processing of regular past tense by late L2 learners of English.

  11. Developing a Service Platform Definition to Promote Evidence-Based Planning and Funding of the Mental Health Service System

    Directory of Open Access Journals (Sweden)

    Yong Yi Lee

    2014-11-01

    Full Text Available Ensuring that a mental health system provides ‘value for money’ requires policy makers to allocate resources to the most cost-effective interventions. Organizing cost-effective interventions into a service delivery framework will require a concept that can guide the mapping of evidence regarding disorder-level interventions to aggregations of services that are meaningful for policy makers. The ‘service platform’ is an emerging concept that could be used to this end, however no explicit definition currently exists in the literature. The aim of this study was to develop a service platform definition that is consistent with how policy makers conceptualize the major elements of the mental health service system and to test the validity and utility of this definition through consultation with mental health policy makers. We derived a provisional definition informed by existing literature and consultation with experienced mental health researchers. Using a modified Delphi method, we obtained feedback from nine Australian policy makers. Respondents provided written answers to a questionnaire eliciting their views on the acceptability, comprehensibility and usefulness of a service platform definition which was subject to qualitative analysis. Overall, respondents understood the definition and found it both acceptable and useful, subject to certain conditions. They also provided suggestions for its improvement. Our findings suggest that the service platform concept could be a useful way of aggregating mental health services as a means for presenting priority setting evidence to policy makers in mental health. However, further development and testing of the concept is required.

  12. Developing a service platform definition to promote evidence-based planning and funding of the mental health service system.

    Science.gov (United States)

    Lee, Yong Yi; Meurk, Carla S; Harris, Meredith G; Diminic, Sandra; Scheurer, Roman W; Whiteford, Harvey A

    2014-11-26

    Ensuring that a mental health system provides 'value for money' requires policy makers to allocate resources to the most cost-effective interventions. Organizing cost-effective interventions into a service delivery framework will require a concept that can guide the mapping of evidence regarding disorder-level interventions to aggregations of services that are meaningful for policy makers. The 'service platform' is an emerging concept that could be used to this end, however no explicit definition currently exists in the literature. The aim of this study was to develop a service platform definition that is consistent with how policy makers conceptualize the major elements of the mental health service system and to test the validity and utility of this definition through consultation with mental health policy makers. We derived a provisional definition informed by existing literature and consultation with experienced mental health researchers. Using a modified Delphi method, we obtained feedback from nine Australian policy makers. Respondents provided written answers to a questionnaire eliciting their views on the acceptability, comprehensibility and usefulness of a service platform definition which was subject to qualitative analysis. Overall, respondents understood the definition and found it both acceptable and useful, subject to certain conditions. They also provided suggestions for its improvement. Our findings suggest that the service platform concept could be a useful way of aggregating mental health services as a means for presenting priority setting evidence to policy makers in mental health. However, further development and testing of the concept is required.

  13. Evidence for Action on HIV Treatment and Care Systems in low and middle-income countries: background and introduction.

    Science.gov (United States)

    Ross, David A; South, Annabelle; Weller, Ian; Hakim, James

    2012-12-01

    Despite the unprecedented scale-up of treatment for HIV in low and middle-income countries over the past decade, 49% of adults and 77% of children in need of HIV treatment still do not have access to it. ART programmes that were initially set up as an emergency response now need to be adapted to ensure that they include all the essential components and are well integrated with other health services; meet the needs of special groups, including children, adolescents, pregnant women and older people; address the mental health needs of HIV-positive people; and monitor as well as report their impact in valid and comparable ways.This supplement is an output from the Evidence for Action on HIV Treatment and Care Systems research programme consortium. Evidence for Action was a 5-year, multidisciplinary research programme, which ran from 2006 to 2011, with partners in India, Malawi, Uganda, Zambia and the United Kingdom.The primary aim of this supplement is to stimulate reflection and provide guidance on what should be in the package of HIV treatment and care systems, as national programmes look to maintain the major advances of the past decade and scale-up treatment to the other 50% of people in need of it.

  14. Evidence for the widespread distribution of CRISPR-Cas system in the Phylum Cyanobacteria.

    Science.gov (United States)

    Cai, Fei; Axen, Seth D; Kerfeld, Cheryl A

    2013-05-01

    Members of the phylum Cyanobacteria inhabit ecologically diverse environments. However, the CRISPR-Cas (clustered regularly interspaced short palindromic repeats, CRISPR associated genes), an extremely adaptable defense system, has not been surveyed in this phylum. We analyzed 126 cyanobacterial genomes and, surprisingly, found CRISPR-Cas in the majority except the marine subclade (Synechococcus and Prochlorococcus), in which cyanophages are a known force shaping their evolution. Multiple observations of CRISPR loci in the absence of cas1/cas2 genes may represent an early stage of losing a CRISPR-Cas locus. Our findings reveal the widespread distribution of their role in the phylum Cyanobacteria and provide a first step to systematically understanding CRISPR-Cas systems in cyanobacteria.

  15. CREDIT RISK ASSESSMENT IN THE ROMANIAN BANKING SYSTEM. EVIDENCE FROM THE RECENT FINANCIAL CRISIS

    Directory of Open Access Journals (Sweden)

    Anamaria Avadanei

    2011-12-01

    Full Text Available The financial crisis followed by the recession has adversely affected the quality of Romanian banking assets. The aim of this paper is to point out the implications of credit risk in the Romanian banking system following the accelerate dynamics of credit activity before the financial crisis and the effects vs. solutions proposed and implemented in recent years. Structured on four parts, the study presents the recent contributions in the crisis-lending relationship, the main features of the Romanian banking system, the evaluation of credit risk in terms of numbers, facts, actions and a short analysis of the correlation between credit indicators (consumer credit, credit risk ratio, medium exchange rate and the number of employees in the economy. To conclude, we propose to define the key points of the future Romanian banking activity.

  16. Experimental evidence for phase synchronization transitions in human cardio-respiratory system

    CERN Document Server

    Bartsch, R; Kantelhardt, J W; Penzel, T; Bartsch, Ronny; Havlin, Shlomo; Kantelhardt, Jan W.; Penzel, Thomas

    2007-01-01

    Transitions in the dynamics of complex systems can be characterized by changes in the synchronization behavior of their components. Taking the human cardio-respiratory system as an example and using an automated procedure for screening the synchrograms of 112 healthy subjects we study the frequency and the distribution of synchronization episodes under different physiological conditions that occur during sleep. We find that phase synchronization between heartbeat and breathing is significantly enhanced during non-rapid-eye-movement (non-REM) sleep (deep sleep and light sleep) and reduced during REM sleep. Our results suggest that the synchronization is mainly due to a weak influence of the breathing oscillator upon the heartbeat oscillator, which is disturbed in the presence of long-term correlated noise, superimposed by the activity of higher brain regions during REM sleep.

  17. Comparative analyses of olfactory systems in terrestrial crabs (Brachyura: evidence for aerial olfaction?

    Directory of Open Access Journals (Sweden)

    Jakob Krieger

    2015-12-01

    Full Text Available Adaptations to a terrestrial lifestyle occurred convergently multiple times during the evolution of the arthropods. This holds also true for the “true crabs” (Brachyura, a taxon that includes several lineages that invaded land independently. During an evolutionary transition from sea to land, animals have to develop a variety of physiological and anatomical adaptations to a terrestrial life style related to respiration, reproduction, development, circulation, ion and water balance. In addition, sensory systems that function in air instead of in water are essential for an animal’s life on land. Besides vision and mechanosensory systems, on land, the chemical senses have to be modified substantially in comparison to their function in water. Among arthropods, insects are the most successful ones to evolve aerial olfaction. Various aspects of terrestrial adaptation have also been analyzed in those crustacean lineages that evolved terrestrial representatives including the taxa Anomala, Brachyura, Amphipoda, and Isopoda. We are interested in how the chemical senses of terrestrial crustaceans are modified to function in air. Therefore, in this study, we analyzed the brains and more specifically the structure of the olfactory system of representatives of brachyuran crabs that display different degrees of terrestriality, from exclusively marine to mainly terrestrial. The methods we used included immunohistochemistry, detection of autofluorescence- and confocal microscopy, as well as three-dimensional reconstruction and morphometry. Our comparative approach shows that both the peripheral and central olfactory pathways are reduced in terrestrial members in comparison to their marine relatives, suggesting a limited function of their olfactory system on land. We conclude that for arthropod lineages that invaded land, evolving aerial olfaction is no trivial task.

  18. Evidence for regulation of gluconeogenesis by the fructose phosphotransferase system in Salmonella typhimurium.

    OpenAIRE

    Chin, A M; Feucht, B U; Saier, M.H.

    1987-01-01

    A genetic locus designated fruR, previously mapped to min 3 on the Salmonella typhimurium chromosome, gave rise to constitutive expression of the fructose (fru) regulon and pleiotropically prevented growth on all Krebs cycle intermediates. Regulatory effects of fruR were independent of cyclic AMP and its receptor protein and did not prevent uptake of Krebs cycle intermediates. Instead, the phosphotransferase system appeared to regulate gluconeogenesis by controlling the activities of phosphoe...

  19. Is the human mirror neuron system plastic? Evidence from a transcranial magnetic stimulation study.

    Science.gov (United States)

    Mehta, Urvakhsh Meherwan; Waghmare, Avinash V; Thirthalli, Jagadisha; Venkatasubramanian, Ganesan; Gangadhar, Bangalore N

    2015-10-01

    Virtual lesions in the mirror neuron network using inhibitory low-frequency (1Hz) transcranial magnetic stimulation (TMS) have been employed to understand its spatio-functional properties. However, no studies have examined the influence of neuro-enhancement by using excitatory high-frequency (20Hz) repetitive transcranial magnetic stimulation (HF-rTMS) on these networks. We used three forms of TMS stimulation (HF-rTMS, single and paired pulse) to investigate whether the mirror neuron system facilitates the motor system during goal-directed action observation relative to inanimate motion (motor resonance), a marker of putative mirror neuron activity. 31 healthy individuals were randomized to receive single-sessions of true or sham HF-rTMS delivered to the left inferior frontal gyrus - a component of the human mirror system. Motor resonance was assessed before and after HF-rTMS using three TMS cortical reactivity paradigms: (a) 120% of resting motor threshold (RMT), (b) stimulus intensity set to evoke motor evoked potential of 1-millivolt amplitude (SI1mV) and (c) a short latency paired pulse paradigm. Two-way RMANOVA showed a significant group (true versus sham) X occasion (pre- and post-HF-rTMS motor resonance) interaction effect for SI1mV [F(df)=6.26 (1, 29), p=0.018] and 120% RMT stimuli [F(df)=7.01 (1, 29), p=0.013] indicating greater enhancement of motor resonance in the true HF-rTMS group than the sham-group. This suggests that HF-rTMS could adaptively modulate properties of the mirror neuron system. This neuro-enhancement effect is a preliminary step that can open translational avenues for novel brain stimulation therapeutics targeting social-cognition deficits in schizophrenia and autism.

  20. Comparative analyses of olfactory systems in terrestrial crabs (Brachyura): evidence for aerial olfaction?

    Science.gov (United States)

    Krieger, Jakob; Braun, Philipp; Rivera, Nicole T; Schubart, Christoph D; Müller, Carsten H G; Harzsch, Steffen

    2015-01-01

    Adaptations to a terrestrial lifestyle occurred convergently multiple times during the evolution of the arthropods. This holds also true for the "true crabs" (Brachyura), a taxon that includes several lineages that invaded land independently. During an evolutionary transition from sea to land, animals have to develop a variety of physiological and anatomical adaptations to a terrestrial life style related to respiration, reproduction, development, circulation, ion and water balance. In addition, sensory systems that function in air instead of in water are essential for an animal's life on land. Besides vision and mechanosensory systems, on land, the chemical senses have to be modified substantially in comparison to their function in water. Among arthropods, insects are the most successful ones to evolve aerial olfaction. Various aspects of terrestrial adaptation have also been analyzed in those crustacean lineages that evolved terrestrial representatives including the taxa Anomala, Brachyura, Amphipoda, and Isopoda. We are interested in how the chemical senses of terrestrial crustaceans are modified to function in air. Therefore, in this study, we analyzed the brains and more specifically the structure of the olfactory system of representatives of brachyuran crabs that display different degrees of terrestriality, from exclusively marine to mainly terrestrial. The methods we used included immunohistochemistry, detection of autofluorescence- and confocal microscopy, as well as three-dimensional reconstruction and morphometry. Our comparative approach shows that both the peripheral and central olfactory pathways are reduced in terrestrial members in comparison to their marine relatives, suggesting a limited function of their olfactory system on land. We conclude that for arthropod lineages that invaded land, evolving aerial olfaction is no trivial task.

  1. Geometric and featural systems, separable and combined: Evidence from reorientation in people with Williams syndrome

    Science.gov (United States)

    Ferrara, Katrina; Landau, Barbara

    2015-01-01

    Spatial reorientation by humans and other animals engages geometric representations of surface layouts as well as featural landmarks; however, the two types of information are thought to be behaviorally and neurally separable. In this paper, we examine the use of these two types of information during reorientation among children and adults with Williams syndrome (WS), a genetic disorder accompanied by abnormalities in brain regions that support use of both geometry and landmarks. Previous studies of reorientation in adolescents and adults with WS have shown deficits in the ability to use geometry for reorientation, but intact ability to use features, suggesting that the two systems can be differentially impaired by genetic disorder. Using a slightly modified layout, we found that many WS participants could use geometry, and most could use features along with geometry. However, the developmental trajectories for the two systems were quite different from one other, and different from those found in typical development. Purely geometric responding was not correlated with age in WS, and search processes appeared similar to those in typically developing (TD) children. In contrast, use of features in combination with geometry was correlated with age in WS, and search processes were distinctly different from TD children. The results support the view that use of geometry and features stem from different underlying mechanisms, that the developmental trajectories and operation of each are altered in WS, and that combination of information from the two systems is atypical. Given brain abnormalities in regions supporting the two kinds of information, our findings suggest that the co-operation of the two systems is functionally altered in this genetic syndrome. PMID:26275835

  2. Evidence that the deep keratin filament systems of the Xenopus embryo act to ensure normal gastrulation.

    OpenAIRE

    Klymkowsky, M. W.; Shook, D R; Maynell, L A

    1992-01-01

    To study the role of keratin filaments in Xenopus development, fertilized eggs were injected with anti-keratin monoclonal antibodies. The anti-keratin monoclonal antibodies AE1 and AE3 induce abnormal gastrulation; in the most severely affected embryos gastrulation fails completely. In contrast, embryos injected with the anti-keratin antibody 1h5 develop normally. Immunocytochemical data indicate that injected 1h5 binds to the dense superficial keratin filament system of the embryo but not to...

  3. System modeling with the DISC framework: evidence from safety-critical domains.

    Science.gov (United States)

    Reiman, Teemu; Pietikäinen, Elina; Oedewald, Pia; Gotcheva, Nadezhda

    2012-01-01

    The objective of this paper is to illustrate the development and application of the Design for Integrated Safety Culture (DISC) framework for system modeling by evaluating organizational potential for safety in nuclear and healthcare domains. The DISC framework includes criteria for good safety culture and a description of functions that the organization needs to implement in order to orient the organization toward the criteria. Three case studies will be used to illustrate the utilization of the DISC framework in practice.

  4. The self-adjusting file (SAF) system: An evidence-based update.

    Science.gov (United States)

    Metzger, Zvi

    2014-09-01

    Current rotary file systems are effective tools. Nevertheless, they have two main shortcomings: They are unable to effectively clean and shape oval canals and depend too much on the irrigant to do the cleaning, which is an unrealistic illusionThey may jeopardize the long-term survival of the tooth via unnecessary, excessive removal of sound dentin and creation of micro-cracks in the remaining root dentin. The new Self-adjusting File (SAF) technology uses a hollow, compressible NiTi file, with no central metal core, through which a continuous flow of irrigant is provided throughout the procedure. The SAF technology allows for effective cleaning of all root canals including oval canals, thus allowing for the effective disinfection and obturation of all canal morphologies. This technology uses a new concept of cleaning and shaping in which a uniform layer of dentin is removed from around the entire perimeter of the root canal, thus avoiding unnecessary excessive removal of sound dentin. Furthermore, the mode of action used by this file system does not apply the machining of all root canals to a circular bore, as do all other rotary file systems, and does not cause micro-cracks in the remaining root dentin. The new SAF technology allows for a new concept in cleaning and shaping root canals: Minimally Invasive 3D Endodontics.

  5. Lead isotope evidence for a young formation age of the Earth-Moon system

    Science.gov (United States)

    Connelly, J. N.; Bizzarro, M.

    2016-10-01

    A model of a giant impact between two planetary bodies is widely accepted to account for the Earth-Moon system. Despite the importance of this event for understanding early Earth evolution and the inventory of Earth's volatiles critical to life, the timing of the impact is poorly constrained. We explore a data-based, two-stage Pb isotope evolution model in which the timing of the loss of volatile Pb relative to refractory U in the aftermath of the giant impact is faithfully recorded in the Pb isotopes of bulk silicate Earth. Constraining the first stage Pb isotopic evolution permits calculating an age range of 4.426-4.417 Ga for the inflection in the U/Pb ratio related to the giant impact. This model is supported by Pb isotope data for angrite meteorites that we use to demonstrate volatility-driven, planetary-scale Pb loss was an efficient process during the early Solar System. The revised age is ∼100 Myr younger than most current estimates for the age of the Moon but fully consistent with recent ages for lunar ferroan anorthosite and the timing of Earth's first crust inferred from the terrestrial zircon record. The estimated loss of ∼98% of terrestrial Pb relative to the Solar System bulk composition by the end of the Moon-forming process implies that the current inventory of Earth's most volatile elements, including water, arrived during post-impact veneering by volatile-rich bodies.

  6. Configuring Balanced Scorecards for Measuring Health System Performance: Evidence from 5 Years' Evaluation in Afghanistan

    Science.gov (United States)

    Edward, Anbrasi; Kumar, Binay; Kakar, Faizullah; Salehi, Ahmad Shah; Burnham, Gilbert; Peters, David H.

    2011-01-01

    Background In 2004, Afghanistan pioneered a balanced scorecard (BSC) performance system to manage the delivery of primary health care services. This study examines the trends of 29 key performance indicators over a 5-year period between 2004 and 2008. Methods and Findings Independent evaluations of performance in six domains were conducted annually through 5,500 patient observations and exit interviews and 1,500 provider interviews in >600 facilities selected by stratified random sampling in each province. Generalized estimating equation (GEE) models were used to assess trends in BSC parameters. There was a progressive improvement in the national median scores scaled from 0–100 between 2004 and 2008 in all six domains: patient and community satisfaction of services (65.3–84.5, pperformance benchmarking during the 5-year period. However, scorecard reconfigurations are needed to integrate effectiveness and efficiency measures and accommodate changes in health systems policy and strategy architecture to ensure its continued relevance and effectiveness as a comprehensive health system performance measure. The process of BSC design and implementation can serve as a valuable prototype for health policy planners managing performance in similar health care contexts. Please see later in the article for the Editors' Summary PMID:21814499

  7. Evidence for a Xer/dif system for chromosome resolution in archaea.

    Directory of Open Access Journals (Sweden)

    Diego Cortez

    2010-10-01

    Full Text Available Homologous recombination events between circular chromosomes, occurring during or after replication, can generate dimers that need to be converted to monomers prior to their segregation at cell division. In Escherichia coli, chromosome dimers are converted to monomers by two paralogous site-specific tyrosine recombinases of the Xer family (XerC/D. The Xer recombinases act at a specific dif site located in the replication termination region, assisted by the cell division protein FtsK. This chromosome resolution system has been predicted in most Bacteria and further characterized for some species. Archaea have circular chromosomes and an active homologous recombination system and should therefore resolve chromosome dimers. Most archaea harbour a single homologue of bacterial XerC/D proteins (XerA, but not of FtsK. Therefore, the role of XerA in chromosome resolution was unclear. Here, we have identified dif-like sites in archaeal genomes by using a combination of modeling and comparative genomics approaches. These sites are systematically located in replication termination regions. We validated our in silico prediction by showing that the XerA protein of Pyrococcus abyssi specifically recombines plasmids containing the predicted dif site in vitro. In contrast to the bacterial system, XerA can recombine dif sites in the absence of protein partners. Whereas Archaea and Bacteria use a completely different set of proteins for chromosome replication, our data strongly suggest that XerA is most likely used for chromosome resolution in Archaea.

  8. Performance of the internal audit department under ERP systems: empirical evidence from Taiwanese firms

    Science.gov (United States)

    Tsai, Wen-Hsien; Chen, Hui-Chiao; Chang, Jui-Chu; Leu, Jun-Der; Chao Chen, Der; Purbokusumo, Yuyun

    2015-10-01

    In this study, the performance of the internal audit department (IAD) and its contribution to a company under enterprise resource planning (ERP) systems was examined. It is anticipated that this will provide insight into the factors perceived to be crucial to a company's effectiveness. A theoretical framework was developed and tested using the sample of Taiwanese companies. Using mail survey procedures, we elicited perceptions from key internal auditors about the ERP system and auditing software, as well as their opinions concerning the IAD's effectiveness and its contribution within a company. Data were analysed using the partial least square (PLS) regression to test the hypotheses. Drawing upon a sample of Taiwanese firms, the study suggests that a firm can improve the performance of the IAD through an enterprise-wide integrated, effective ERP system and appropriate auditing software. At the same time, the performance of the IAD can also contribute significantly to the company. The results also show that investments in computer-assisted auditing techniques (CAATs) are crucial due to their tremendous effectiveness in regard to the performance of the IAD and for the contributions CAATs can make to a company.

  9. Are mirror neurons the basis of speech perception? Evidence from five cases with damage to the purported human mirror system.

    Science.gov (United States)

    Rogalsky, Corianne; Love, Tracy; Driscoll, David; Anderson, Steven W; Hickok, Gregory

    2011-01-01

    The discovery of mirror neurons in macaque has led to a resurrection of motor theories of speech perception. Although the majority of lesion and functional imaging studies have associated perception with the temporal lobes, it has also been proposed that the 'human mirror system', which prominently includes Broca's area, is the neurophysiological substrate of speech perception. Although numerous studies have demonstrated a tight link between sensory and motor speech processes, few have directly assessed the critical prediction of mirror neuron theories of speech perception, namely that damage to the human mirror system should cause severe deficits in speech perception. The present study measured speech perception abilities of patients with lesions involving motor regions in the left posterior frontal lobe and/or inferior parietal lobule (i.e., the proposed human 'mirror system'). Performance was at or near ceiling in patients with fronto-parietal lesions. It is only when the lesion encroaches on auditory regions in the temporal lobe that perceptual deficits are evident. This suggests that 'mirror system' damage does not disrupt speech perception, but rather that auditory systems are the primary substrate for speech perception.

  10. Evidence for a specialized role of the locus coeruleus noradrenergic system in cortical circuitries and behavioral operations.

    Science.gov (United States)

    Chandler, Daniel J

    2016-06-15

    The brainstem nucleus locus coeruleus (LC) innervates the entire central nervous system and is the primary source of norepinephrine (NE) to the neocortex. While classically considered a homogenous modulator of forebrain activity by virtue of highly widespread and divergent axons, recent behavioral and pharmacological evidence suggest this nucleus may execute distinct operations within functionally distinct terminal fields. Summarized in this review are the anatomical and physiological properties of the nucleus within a historical context that led to the interpretation of the nucleus as a homogeneous entity with uniform and simultaneous actions throughout its terminal fields. Also included are findings from several laboratories which point to a more nuanced model of LC/NE function that parallels that seen in other forebrain-projecting monoaminergic nuclei. Such compartmentalized models of the nucleus promote the idea that specific LC circuits are involved in discrete behavioral operations, and therefore, by identifying the networks that are engaged by LC, the substrates for these behaviors can be identified and manipulated. Perturbations in the functional anatomy and physiology of this system may be related to neuropsychiatric conditions associated with dysregulation of the LC-noradrenergic system such as attention deficit hyperactivity disorder. Recent findings regarding the organization and operation of the LC/NE system collectively challenge the classical view of the nucleus as a relatively homogenous modulator of forebrain activity and provide the basis for a renewed scientific interest in this region of the brain. This article is part of a Special Issue entitled SI: Noradrenergic System.

  11. The Adaptability of Marketing Systems to Interventions in Developing Countries: Evidence from the Pineapple System in Benin

    NARCIS (Netherlands)

    Hounhouigan, M.H.; Ingenbleek, P.T.M.; Lans, van der I.A.; Trijp, van H.C.M.; Linnemann, A.R.

    2014-01-01

    In general marketing theory, marketing systems are assumed to adapt to facilitate further economic development. However, such adaptability may be less obvious in the context of developing countries due to features in the social matrix of these countries. The present study explores adaptation in the

  12. Molecular evidence for abiotic sulfurization of dissolved organic matter in marine shallow hydrothermal systems

    Science.gov (United States)

    Gomez-Saez, Gonzalo V.; Niggemann, Jutta; Dittmar, Thorsten; Pohlabeln, Anika M.; Lang, Susan Q.; Noowong, Ann; Pichler, Thomas; Wörmer, Lars; Bühring, Solveig I.

    2016-10-01

    Shallow submarine hydrothermal systems are extreme environments with strong redox gradients at the interface of hot, reduced fluids and cold, oxygenated seawater. Hydrothermal fluids are often depleted in sulfate when compared to surrounding seawater and can contain high concentrations of hydrogen sulfide (H2S). It is well known that sulfur in its various oxidation states plays an important role in processing and transformation of organic matter. However, the formation and the reactivity of dissolved organic sulfur (DOS) in the water column at hydrothermal systems are so far not well understood. We investigated DOS dynamics and its relation to the physicochemical environment by studying the molecular composition of dissolved organic matter (DOM) in three contrasting shallow hydrothermal systems off Milos (Eastern Mediterranean), Dominica (Caribbean Sea) and Iceland (North Atlantic). We used ultra-high resolution Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) to characterize the DOM on a molecular level. The molecular information was complemented with general geochemical data, quantitative dissolved organic carbon (DOC) and DOS analyses as well as isotopic measurements (δ2H, δ18O and F14C). In contrast to the predominantly meteoric fluids from Dominica and Iceland, hydrothermal fluids from Milos were mainly fed by recirculating seawater. The hydrothermal fluids from Milos were enriched in H2S and DOS, as indicated by high DOS/DOC ratios and by the fact that >90% of all assigned DOM formulas that were exclusively present in the fluids contained sulfur. In all three systems, DOS from hydrothermal fluids had on average lower O/C ratios (0.26-0.34) than surrounding surface seawater DOS (0.45-0.52), suggesting shallow hydrothermal systems as a source of reduced DOS, which will likely get oxidized upon contact with oxygenated seawater. Evaluation of hypothetical sulfurization reactions suggests DOM reduction and sulfurization during seawater

  13. Evidence Suggesting a Role of Iron in a Mouse Model of Nephrogenic Systemic Fibrosis.

    Directory of Open Access Journals (Sweden)

    Chhanda Bose

    Full Text Available Nephrogenic systemic fibrosis is associated with gadolinium contrast exposure in patients with reduced kidney function and carries high morbidity and mortality. We have previously demonstrated that gadolinium contrast agents induce in vivo systemic iron mobilization and in vitro differentiation of peripheral blood mononuclear cells into ferroportin (iron exporter-expressing fibrocytic cells. In the present study we examined the role of iron in a mouse model of nephrogenic systemic fibrosis. Chronic kidney disease was induced in 8-week-old male Balb/C mice with a two-step 5/6 nephrectomy surgery. Five groups of mice were studied: control (n = 5, sham surgery control (n = 5, chronic kidney disease control (n = 4, chronic kidney disease injected with 0.5 mmol/kg body weight of Omniscan 3 days per week, for a total of 10 injections (n = 8, and chronic kidney disease with Omniscan plus deferiprone, 125 mg/kg, in drinking water (n = 9. Deferiprone was continued for 16 weeks until the end of the experiment. Mice with chronic kidney disease injected with Omniscan developed skin changes characteristic of nephrogenic systemic fibrosis including hair loss, reddening, ulceration, and skin tightening by 10 to 16 weeks. Histopathological sections demonstrated dermal fibrosis with increased skin thickness (0.25±0.06 mm, sham; 0.34±+0.3 mm, Omniscan-injected. Additionally, we observed an increase in tissue infiltration of ferroportin-expressing, fibrocyte-like cells accompanied by tissue iron accumulation in the skin of the Omniscan-treated mice. The deferiprone-treated group had significantly decreased skin thickness (p<0.05 and significantly decreased dermal fibrosis compared to the Omniscan-only group. In addition, iron chelation prevented tissue infiltration of ferroportin-expressing, fibrocyte-like cells. Our in vitro experiments demonstrated that exposure to Omniscan resulted in the release of catalytic iron and this was prevented by the iron chelator

  14. Configuring balanced scorecards for measuring health system performance: evidence from 5 years' evaluation in Afghanistan.

    Directory of Open Access Journals (Sweden)

    Anbrasi Edward

    2011-07-01

    Full Text Available BACKGROUND: In 2004, Afghanistan pioneered a balanced scorecard (BSC performance system to manage the delivery of primary health care services. This study examines the trends of 29 key performance indicators over a 5-year period between 2004 and 2008. METHODS AND FINDINGS: Independent evaluations of performance in six domains were conducted annually through 5,500 patient observations and exit interviews and 1,500 provider interviews in >600 facilities selected by stratified random sampling in each province. Generalized estimating equation (GEE models were used to assess trends in BSC parameters. There was a progressive improvement in the national median scores scaled from 0-100 between 2004 and 2008 in all six domains: patient and community satisfaction of services (65.3-84.5, p<0.0001; provider satisfaction (65.4-79.2, p<0.01; capacity for service provision (47.4-76.4, p<0.0001; quality of services (40.5-67.4, p<0.0001; and overall vision for pro-poor and pro-female health services (52.0-52.6. The financial domain also showed improvement until 2007 (84.4-95.7, p<0.01, after which user fees were eliminated. By 2008, all provinces achieved the upper benchmark of national median set in 2004. CONCLUSIONS: The BSC has been successfully employed to assess and improve health service capacity and service delivery using performance benchmarking during the 5-year period. However, scorecard reconfigurations are needed to integrate effectiveness and efficiency measures and accommodate changes in health systems policy and strategy architecture to ensure its continued relevance and effectiveness as a comprehensive health system performance measure. The process of BSC design and implementation can serve as a valuable prototype for health policy planners managing performance in similar health care contexts. Please see later in the article for the Editors' Summary.

  15. Chorea in systemic lupus erythematosus: evidence for bilateral putaminal hypermetabolism on F-18 FDG PET

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Wook Jang; Chung, Son Mi; Koh, Su Jin; Lee, Chang Keun; Yoo, Bin; Moon, Hee Bom [College of Medicine, Ulsan Univ., Seoul (Korea, Republic of); Kim, Jae Seung; Im, Joo Hyuk [Asan Medical Center, Seoul (Korea, Republic of)

    2003-10-01

    We describe a 54-year-old woman with systemic lupus erythematosus (SLE) who suddenly presented with chorea and had positive antiphospholipid antibodies. F-18 FDG PET showed abnormally increased glucose metabolism in bilateral putamen and primary motor cotex. Tc-99m ECD SPECT also showed abnormally increased regional cerebral blood flow in bilateral putamen. She was treated with corticosteroid and aspirin after which the symptoms improved. Four months later, follow up F-18 FDG PET showed improvement with resolution of hypermetabolism in bilateral putamen. This case suggests that striatal hypermetabolism is associated with chorea in SLE.

  16. Evidence for a nonequilibrated dinuclear system in dissipative collisions at 19 MeV/nucleon

    Energy Technology Data Exchange (ETDEWEB)

    Casini, G.; Stefanini, A.A.; Bini, M.; Maurenzig, P.R.; Olmi, A.; Poggi, G. (Universita di Firenze and Istituto Nazionale di Fisica Nucleare, I-50125 Florence (Italy)); Charity, R.J.; Freifelder, R.; Gobbi, A.; Hildenbrand, K.D.; Tanaka, M.H.; Wessels, J.P. (Gesellschaft fuer Schwerionenforschung, W-6100 Darmstadt (Germany))

    1991-12-09

    Exclusive measurements of two- and three-body events were performed for the system {sup 120}Sn+{sup 100}Mo at 19.1 MeV/nucleon. Most ternary events are consistent with sequential processes in which one of the two deep-inelastic fragments fissions. For such events large differences are found between the fission probabilities of projectilelike and targetlike fragments of a given mass, this probability being larger for the nucleus which gained nucleons. This behavior demonstrates that there is a lack of equilibrium at the end of the deep-inelastic collision.

  17. Evidence for a nonequilibrated dinuclear system in dissipative collisions at 19 MeV/nucleon

    Science.gov (United States)

    Casini, G.; Stefanini, A. A.; Bini, M.; Maurenzig, P. R.; Olmi, A.; Poggi, G.; Charity, R. J.; Freifelder, R.; Gobbi, A.; Hildenbrand, K. D.; Tanaka, M. H.; Wessels, J. P.

    1991-12-01

    Exclusive measurements of two- and three-body events were performed for the system 120Sn+100Mo at 19.1 MeV/nucleon. Most ternary events are consistent with sequential processes in which one of the two deep-inelastic fragments fissions. For such events large differences are found between the fission probabilities of projectilelike and targetlike fragments of a given mass, this probability being larger for the nucleus which gained nucleons. This behavior demonstrates that there is a lack of equilibrium at the end of the deep-inelastic collision.

  18. Appointment reminder systems are effective but not optimal: results of a systematic review and evidence synthesis employing realist principles

    Directory of Open Access Journals (Sweden)

    McLean SM

    2016-04-01

    Full Text Available Sionnadh Mairi McLean,1 Andrew Booth,2 Melanie Gee,3 Sarah Salway,2 Mark Cobb,4 Sadiq Bhanbhro,3 Susan A Nancarrow5 1Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield, UK; 2School of Health and Related Research, University of Sheffield, Sheffield, UK; 3Centre for Health and Social Care Research, Sheffield Hallam University, Sheffield, UK; 4Therapeutics & Palliative Care, Sheffield Teaching Hospitals, Sheffield, UK; 5School of Health and Human Science, Southern Cross University, East Lismore, NSW, Australia Abstract: Missed appointments are an avoidable cost and resource inefficiency which impact upon the health of the patient and treatment outcomes. Health care services are increasingly utilizing reminder systems to manage these negative effects. This study explores the effectiveness of reminder systems for promoting attendance, cancellations, and rescheduling of appointments across all health care settings and for particular patient groups and the contextual factors which indicate that reminders are being employed sub-optimally. We used three inter-related reviews of quantitative and qualitative evidence. Firstly, using pre-existing models and theories, we developed a conceptual framework to inform our understanding of the contexts and mechanisms which influence reminder effectiveness. Secondly, we performed a review following Centre for Reviews and Dissemination guidelines to investigate the effectiveness of different methods of reminding patients to attend health service appointments. Finally, to supplement the effectiveness information, we completed a review informed by realist principles to identify factors likely to influence non-attendance behaviors and the effectiveness of reminders. We found consistent evidence that all types of reminder systems are effective at improving appointment attendance across a range of health care settings and patient populations. Reminder systems may also increase cancellation and

  19. Genetic evidence of a high-affinity cyanuric acid transport system in Pseudomonas sp. ADP.

    Science.gov (United States)

    Platero, Ana I; Santero, Eduardo; Govantes, Fernando

    2014-03-01

    The Pseudomonas sp. ADP plasmid pADP-1 encodes the activities involved in the hydrolytic degradation of the s-triazine herbicide atrazine. Here, we explore the presence of a specific transport system for the central intermediate of the atrazine utilization pathway, cyanuric acid, in Pseudomonas sp. ADP. Growth in fed-batch cultures containing limiting cyanuric acid concentrations is consistent with high-affinity transport of this substrate. Acquisition of the ability to grow at low cyanuric acid concentrations upon conjugal transfer of pADP1 to the nondegrading host Pseudomonas putida KT2442 suggests that all activities required for this phenotype are encoded in this plasmid. Co-expression of the pADP1-borne atzDEF and atzTUVW genes, encoding the cyanuric acid utilization pathway and the subunits of an ABC-type solute transport system, in P. putida KT2442 was sufficient to promote growth at cyanuric acid concentrations as low as 50 μM in batch culture. Taken together, our results strongly suggest that the atzTUVW gene products are involved in high-affinity transport of cyanuric acid.

  20. Lead isotope evidence for a young formation age of the Earth–Moon system

    DEFF Research Database (Denmark)

    Connelly, James; Bizzarro, Martin

    2016-01-01

    A model of a giant impact between two planetary bodies is widely accepted to account for the Earth–Moon system. Despite the importance of this event for understanding early Earth evolution and the inventory of Earth's volatiles critical to life, the timing of the impact is poorly constrained. We ...... composition by the end of the Moon-forming process implies that the current inventory of Earth's most volatile elements, including water, arrived during post-impact veneering by volatile-rich bodies.......A model of a giant impact between two planetary bodies is widely accepted to account for the Earth–Moon system. Despite the importance of this event for understanding early Earth evolution and the inventory of Earth's volatiles critical to life, the timing of the impact is poorly constrained. We...... explore a data-based, two-stage Pb isotope evolution model in which the timing of the loss of volatile Pb relative to refractory U in the aftermath of the giant impact is faithfully recorded in the Pb isotopes of bulk silicate Earth. Constraining the first stage Pb isotopic evolution permits calculating...

  1. Bone as an ion exchange system: evidence for a link between mechanotransduction and metabolic needs.

    Science.gov (United States)

    Rubinacci, A; Covini, M; Bisogni, C; Villa, I; Galli, M; Palumbo, C; Ferretti, M; Muglia, M A; Marotti, G

    2002-04-01

    To detect whether the mutual interaction occurring between the osteocytes-bone lining cells system (OBLCS) and the bone extracellular fluid (BECF) is affected by load through a modification of the BECF-extracellular fluid (ECF; systemic extracellular fluid) gradient, mice metatarsal bones immersed in ECF were subjected ex vivo to a 2-min cyclic axial load of different amplitudes and frequencies. The electric (ionic) currents at the bone surface were measured by a vibrating probe after having exposed BECF to ECF through a transcortical hole. The application of different loads and different frequencies increased the ionic current in a dose-dependent manner. The postload current density subsequently decayed following an exponential pattern. Postload increment's amplitude and decay were dependent on bone viability. Dummy and static loads did not induce current density modifications. Because BECF is perturbed by loading, it is conceivable that OBLCS tends to restore BECF preload conditions by controlling ion fluxes at the bone-plasma interface to fulfill metabolic needs. Because the electric current reflects the integrated activity of OBLCS, its evaluation in transgenic mice engineered to possess genetic lesions in channels or matrix constituents could be helpful in the characterization of the mechanical and metabolic functions of bone.

  2. Use of a systems approach and evidence-based One Health for zoonoses research.

    Science.gov (United States)

    Asokan, G V; Asokan, Vanitha; Fedorowicz, Zbys; Tharyan, Prathap

    2011-05-01

    The World Health Organization estimates that 25% of the 57 million annual deaths that occur globally are caused by microbes. A study reported 1415 species of infectious organisms are known to be pathogenic to humans. Zoonoses constitute 61% of all known infectious diseases, with humans serving as the primary reservoir for only 3% of them. Of the 175 infectious species considered to be emerging, 75% are zoonotic. Zoonotic diseases and their impact on human and animal health are not monitored, prevented, and treated in an integrated way, despite the fact that etiologies and treatments are similar across species. The efficacy and resistance of a drug in one species has a bearing on others, in the context of zoonoses. Further, an RCT involving many species is effective in a natural setting, is robust, and may require fewer human volunteers. One Health is based on a systems approach and a collaborative effort of multiple disciplines - working locally, nationally, and globally - to attain optimal health for people, animals, and the environment. Systematic reviews and meta-analyses have so far been independent and discipline oriented. Pooling of results for diagnostic test accuracies and treatment effects of drugs for zoonoses across species has to be done, since the results of preclinical trials emanate from laboratory animals. The Cochrane Collaboration is the platform of choice to initiate a new group on zoonoses to carry out systematic meta-analyses of diagnostic tests and drug efficacies without bias, thus underpinning the systems approach and One Health.

  3. A new analysis of the WASP-3 system: no evidence for an additional companion

    CERN Document Server

    Montalto, M; Boue', G; Mortier, A; Boisse, I; Oshagh, M; Maturi, M; Figueira, P; Sousa, S; Santos, N C

    2012-01-01

    In this work we investigate the problem concerning the presence of additional bodies gravitationally bounded with the WASP-3 system. We present eight new transits of this planet and analyse all the photometric and radial velocity data published so far. We did not observe significant periodicities in the Fourier spectrum of the observed minus calculated (O-C) transit timing and radial velocity diagrams (the highest peak having false-alarm probabilities of 56 per cent and 31 per cent, respectively) or long-term trends. Combining all the available information, we conclude that the radial velocity and transit timing techniques exclude, at 99 per cent confidence limit, any perturber more massive than M \\gtrsim 100 M_Earth with periods up to 10 times the period of the inner planet. We also investigate the possible presence of an exomoon on this system and determined that considering the scatter of the O-C transit timing residuals a coplanar exomoon would likely produce detectable transits. This hypothesis is howeve...

  4. Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repellent deet

    Directory of Open Access Journals (Sweden)

    Dimitrov Mitko

    2009-08-01

    Full Text Available Abstract Background N,N-Diethyl-3-methylbenzamide (deet remains the gold standard for insect repellents. About 200 million people use it every year and over 8 billion doses have been applied over the past 50 years. Despite the widespread and increased interest in the use of deet in public health programmes, controversies remain concerning both the identification of its target sites at the olfactory system and its mechanism of toxicity in insects, mammals and humans. Here, we investigated the molecular target site for deet and the consequences of its interactions with carbamate insecticides on the cholinergic system. Results By using toxicological, biochemical and electrophysiological techniques, we show that deet is not simply a behaviour-modifying chemical but that it also inhibits cholinesterase activity, in both insect and mammalian neuronal preparations. Deet is commonly used in combination with insecticides and we show that deet has the capacity to strengthen the toxicity of carbamates, a class of insecticides known to block acetylcholinesterase. Conclusion These findings question the safety of deet, particularly in combination with other chemicals, and they highlight the importance of a multidisciplinary approach to the development of safer insect repellents for use in public health.

  5. Physiological complexity and system adaptability: evidence from postural control dynamics of older adults.

    Science.gov (United States)

    Manor, Brad; Costa, Madalena D; Hu, Kun; Newton, Elizabeth; Starobinets, Olga; Kang, Hyun Gu; Peng, C K; Novak, Vera; Lipsitz, Lewis A

    2010-12-01

    The degree of multiscale complexity in human behavioral regulation, such as that required for postural control, appears to decrease with advanced aging or disease. To help delineate causes and functional consequences of complexity loss, we examined the effects of visual and somatosensory impairment on the complexity of postural sway during quiet standing and its relationship to postural adaptation to cognitive dual tasking. Participants of the MOBILIZE Boston Study were classified into mutually exclusive groups: controls [intact vision and foot somatosensation, n = 299, 76 ± 5 (SD) yr old], visual impairment only (Postural sway (i.e., center-of-pressure) dynamics were assessed during quiet standing and cognitive dual tasking, and a complexity index was quantified using multiscale entropy analysis. Postural sway speed and area, which did not correlate with complexity, were also computed. During quiet standing, the complexity index (mean ± SD) was highest in controls (9.5 ± 1.2) and successively lower in the visual (9.1 ± 1.1), somatosensory (8.6 ± 1.6), and combined (7.8 ± 1.3) impairment groups (P = 0.001). Dual tasking resulted in increased sway speed and area but reduced complexity (P postural sway speed from quiet standing to dual-tasking conditions. Sensory impairments contributed to decreased postural sway complexity, which reflected reduced adaptive capacity of the postural control system. Relatively low baseline complexity may, therefore, indicate control systems that are more vulnerable to cognitive and other stressors.

  6. Targeting the Glutamatergic System to Treat Pathological Gambling: Current Evidence and Future Perspectives

    Directory of Open Access Journals (Sweden)

    Mauro Pettorruso

    2014-01-01

    Full Text Available Pathological gambling or gambling disorder has been defined by the DSM-5 as a behavioral addiction. To date, its pathophysiology is not completely understood and there is no FDA-approved treatment for gambling disorders. Glutamate is the principal excitatory neurotransmitter in the nervous system and it has been recently involved in the pathophysiology of addictive behaviors. In this paper, we review the current literature on a class of drugs that act as modulating glutamate system in PG. A total of 19 studies have been included, according to inclusion and exclusion criteria. Clinical trial and case series using glutamatergic drugs (N-acetylcysteine, memantine, amantadine, topiramate, acamprosate, baclofen, gabapentin, pregabalin, and modafinil will be presented to elucidate the effectiveness on gambling behaviors and on the related clinical dimensions (craving, withdrawal, and cognitive symptoms in PG patients. The results have been discussed to gain more insight in the pathophysiology and treatment of PG. In conclusion, manipulation of glutamatergic neurotransmission appears to be promising in developing improved therapeutic agents for the treatment of gambling disorders. Further studies are required. Finally, we propose future directions and challenges in this research area.

  7. Category Number Impacts Rule-Based "and" Information-Integration Category Learning: A Reassessment of Evidence for Dissociable Category-Learning Systems

    Science.gov (United States)

    Stanton, Roger D.; Nosofsky, Robert M.

    2013-01-01

    Researchers have proposed that an explicit reasoning system is responsible for learning rule-based category structures and that a separate implicit, procedural-learning system is responsible for learning information-integration category structures. As evidence for this multiple-system hypothesis, researchers report a dissociation based on…

  8. Reassessment of the evidence for postcranial skeletal pneumaticity in Triassic archosaurs, and the early evolution of the avian respiratory system.

    Directory of Open Access Journals (Sweden)

    Richard J Butler

    Full Text Available Uniquely among extant vertebrates, birds possess complex respiratory systems characterised by the combination of small, rigid lungs, extensive pulmonary air sacs that possess diverticula that invade (pneumatise the postcranial skeleton, unidirectional ventilation of the lungs, and efficient crosscurrent gas exchange. Crocodilians, the only other living archosaurs, also possess unidirectional lung ventilation, but lack true air sacs and postcranial skeletal pneumaticity (PSP. PSP can be used to infer the presence of avian-like pulmonary air sacs in several extinct archosaur clades (non-avian theropod dinosaurs, sauropod dinosaurs and pterosaurs. However, the evolution of respiratory systems in other archosaurs, especially in the lineage leading to crocodilians, is poorly documented. Here, we use µCT-scanning to investigate the vertebral anatomy of Triassic archosaur taxa, from both the avian and crocodilian lineages as well as non-archosaurian diapsid outgroups. Our results confirm previous suggestions that unambiguous evidence of PSP (presence of internal pneumatic cavities linked to the exterior by foramina is found only in bird-line (ornithodiran archosaurs. We propose that pulmonary air sacs were present in the common ancestor of Ornithodira and may have been subsequently lost or reduced in some members of the clade (notably in ornithischian dinosaurs. The development of these avian-like respiratory features might have been linked to inferred increases in activity levels among ornithodirans. By contrast, no crocodile-line archosaur (pseudosuchian exhibits evidence for unambiguous PSP, but many of these taxa possess the complex array of vertebral laminae and fossae that always accompany the presence of air sacs in ornithodirans. These laminae and fossae are likely homologous with those in ornithodirans, which suggests the need for further investigation of the hypothesis that a reduced, or non-invasive, system of pulmonary air sacs may be have

  9. Physiochemical Evidence of Faulting Processes and Modeling of Fluid in Evolving Fault Systems in Southern California

    Energy Technology Data Exchange (ETDEWEB)

    Boles, James [Professor

    2013-05-24

    Our study targets recent (Plio-Pleistocene) faults and young (Tertiary) petroleum fields in southern California. Faults include the Refugio Fault in the Transverse Ranges, the Ellwood Fault in the Santa Barbara Channel, and most recently the Newport- Inglewood in the Los Angeles Basin. Subsurface core and tubing scale samples, outcrop samples, well logs, reservoir properties, pore pressures, fluid compositions, and published structural-seismic sections have been used to characterize the tectonic/diagenetic history of the faults. As part of the effort to understand the diagenetic processes within these fault zones, we have studied analogous processes of rapid carbonate precipitation (scaling) in petroleum reservoir tubing and manmade tunnels. From this, we have identified geochemical signatures in carbonate that characterize rapid CO2 degassing. These data provide constraints for finite element models that predict fluid pressures, multiphase flow patterns, rates and patterns of deformation, subsurface temperatures and heat flow, and geochemistry associated with large fault systems.

  10. Molecular evidence for central nervous system involvement in children with newly diagnosed acute lymphoblastic leukemia.

    Science.gov (United States)

    Januszkiewicz, D A; Nowak, J S

    1995-01-01

    Central nervous system (CNS) involvement in children with newly diagnosed acute lymphoblastic leukemia (ALL) would have profound implication for the prognosis and accurate stratification of CNS prophylactic therapy. Using PCR technique with specific primers for V, D and J segments of TCRD gene, the pattern of TCRD gene rearrangements in bone marrow lymphoblasts and in cells from cerebrospinal fluid (CSF) have been investigated. The study involved 21 children at the time of diagnosis with B-lineage ALL. In nine of 21 patients incomplete TCRDVD gene rearrangement has been found in CSF cells, which was identical to that observed in bone marrow of the same children. It can be concluded that at least in 43 per cent of all analysed cases, there were signs of CNS involvement in newly diagnosed ALL patients.

  11. Evidence of muscarinic acetylcholine receptors in the retinal centrifugal system of the chick

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    Calaza K.C.

    2000-01-01

    Full Text Available In this study we characterize the presence of muscarinic acetylcholine receptors (mAChR in the isthmo-optic nucleus (ION of chicks by immunohistochemistry with the M35 antibody. Some M35-immunoreactive fibers were observed emerging from the retinal optic nerve insertion, suggesting that they could be centrifugal fibers. Indeed, intraocular injections of cholera toxin B (CTb, a retrograde tracer, and double-labeling with M35 and CTb in the ION confirmed this hypothesis. The presence of M35-immunoreactive cells and the possible mAChR expression in ION and ectopic neuron cells in the chick brain strongly suggest the existence of such a cholinergic system in this nucleus and that acetylcholine release from amacrine cells may mediate interactions between retinal cells and ION terminals.

  12. The Size-Frequency Distribution of the Zodiacal Cloud Evidence from the Solar System Dust Bands

    CERN Document Server

    Grogan, K; Durda, D D

    2000-01-01

    Recent observations of the size-frequency distribution of zodiacal cloud particles obtained from the cratering record on the LDEF satellite (Love and Brownlee 1993) reveal a significant large particle population (100 micron diameter or greater) near 1 AU. Our previous modeling of the Solar System dust bands (Grogan et al 1997), features of the zodiacal cloud associated with the comminution of Hirayama family asteroids, has been limited by the fact that only small particles (25 micron diameter or smaller) have been considered. This was due to the prohibitively large amount of computing power required to numerically analyze the dynamics of larger particles. The recent availability of cheap, fast processors has finally made this work possible. Models of the dust bands are created, built from individual dust particle orbits, taking into account a size-frequency distribution of the material and the dynamical history of the constituent particles. These models are able to match both the shapes and amplitudes of the ...

  13. EVIDENCE FOR MULTIPLE SOURCES OF {sup 10}Be IN THE EARLY SOLAR SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Wielandt, Daniel; Krot, Alexander N.; Bizzarro, Martin [Centre for Star and Planet Formation, Natural History Museum of Denmark, University of Copenhagen, Copenhagen DK-1350 (Denmark); Nagashima, Kazuhide; Huss, Gary R. [Hawai' i Institute of Geophysics and Planetology, University of Hawai' i at Manoa, HI 96822 (United States); Ivanova, Marina A. [Vernadsky Institute of Geochemistry and Analytical Chemistry, Moscow 119991 (Russian Federation)

    2012-04-01

    Beryllium-10 is a short-lived radionuclide (t{sub 1/2} = 1.4 Myr) uniquely synthesized by spallation reactions and inferred to have been present when the solar system's oldest solids (calcium-aluminum-rich inclusions, CAIs) formed. Yet, the astrophysical site of {sup 10}Be nucleosynthesis is uncertain. We report Li-Be-B isotope measurements of CAIs from CV chondrites, including CAIs that formed with the canonical {sup 26}Al/{sup 27}Al ratio of {approx}5 Multiplication-Sign 10{sup -5} (canonical CAIs) and CAIs with Fractionation and Unidentified Nuclear isotope effects (FUN-CAIs) characterized by {sup 26}Al/{sup 27}Al ratios much lower than the canonical value. Our measurements demonstrate the presence of four distinct fossil {sup 10}Be/{sup 9}Be isochrons, lower in the FUN-CAIs than in the canonical CAIs, and variable within these classes. Given that FUN-CAI precursors escaped evaporation-recondensation prior to evaporative melting, we suggest that the {sup 10}Be/{sup 9}Be ratio recorded by FUN-CAIs represents a baseline level present in presolar material inherited from the protosolar molecular cloud, generated via enhanced trapping of galactic cosmic rays. The higher and possibly variable apparent {sup 10}Be/{sup 9}Be ratios of canonical CAIs reflect additional spallogenesis, either in the gaseous CAI-forming reservoir, or in the inclusions themselves: this indicates at least two nucleosynthetic sources of {sup 10}Be in the early solar system. The most promising locale for {sup 10}Be synthesis is close to the proto-Sun during its early mass-accreting stages, as these are thought to coincide with periods of intense particle irradiation occurring on timescales significantly shorter than the formation interval of canonical CAIs.

  14. Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.

    Science.gov (United States)

    Prusiner, Stanley B; Woerman, Amanda L; Mordes, Daniel A; Watts, Joel C; Rampersaud, Ryan; Berry, David B; Patel, Smita; Oehler, Abby; Lowe, Jennifer K; Kravitz, Stephanie N; Geschwind, Daniel H; Glidden, David V; Halliday, Glenda M; Middleton, Lefkos T; Gentleman, Steve M; Grinberg, Lea T; Giles, Kurt

    2015-09-22

    Prions are proteins that adopt alternative conformations that become self-propagating; the PrP(Sc) prion causes the rare human disorder Creutzfeldt-Jakob disease (CJD). We report here that multiple system atrophy (MSA) is caused by a different human prion composed of the α-synuclein protein. MSA is a slowly evolving disorder characterized by progressive loss of autonomic nervous system function and often signs of parkinsonism; the neuropathological hallmark of MSA is glial cytoplasmic inclusions consisting of filaments of α-synuclein. To determine whether human α-synuclein forms prions, we examined 14 human brain homogenates for transmission to cultured human embryonic kidney (HEK) cells expressing full-length, mutant human α-synuclein fused to yellow fluorescent protein (α-syn140*A53T-YFP) and TgM83(+/-) mice expressing α-synuclein (A53T). The TgM83(+/-) mice that were hemizygous for the mutant transgene did not develop spontaneous illness; in contrast, the TgM83(+/+) mice that were homozygous developed neurological dysfunction. Brain extracts from 14 MSA cases all transmitted neurodegeneration to TgM83(+/-) mice after incubation periods of ∼120 d, which was accompanied by deposition of α-synuclein within neuronal cell bodies and axons. All of the MSA extracts also induced aggregation of α-syn*A53T-YFP in cultured cells, whereas none of six Parkinson's disease (PD) extracts or a control sample did so. Our findings argue that MSA is caused by a unique strain of α-synuclein prions, which is different from the putative prions causing PD and from those causing spontaneous neurodegeneration in TgM83(+/+) mice. Remarkably, α-synuclein is the first new human prion to be identified, to our knowledge, since the discovery a half century ago that CJD was transmissible.

  15. Provincial Health Accounts in Kerman, Iran: An Evidence of a “Mixed” Healthcare Financing System

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    Mohammad Hossein Mehrolhassani

    2014-02-01

    Full Text Available Background Provincial Health Accounts (PHA as a subset of National Health Accounts (NHA present financial information for health sectors. It leads to a logical decision making for policy-makers in order to achieve health system goals, especially Fair Financial Contribution (FFC. This study aimed to examine Health Accounts in Kerman Province. Methods The present analytical study was carried out retrospectively between 2008 and 2011. The research population consisted of urban and rural households as well as providers and financial agents in health sectors of Kerman Province. The purposeful sampling included 16 provincial organizations. To complete data, the report on Kerman household expenditure was taken as a data source from the Governor-General’s office. In order to classify the data, the International Classification for Health Accounts (ICHA method was used, in which data set was adjusted for the province. Results During the study, the governmental and non-governmental fund shares of the health sector in Kerman were 27.22% and 72.78% respectively. The main portion of financial sources (59.41 was related to private household funds, of which the Out-of-Pocket (OOP payment mounted to 92.35%. Overall, 54.86% of all financial sources were covered by OOP. The greatest portion of expenditure of Total Healthcare Expenditures (THEs (65.19% was related to curative services. Conclusion The major portion of healthcare expenditures was related to the OOP payment which is compatible with the national average rate in Iran. However, health expenditure per capita, was two and a half times higher than the national average. By performing the Family Physician Program (FPP and emphasizing Social Determinant of Health (SDH approach in the Iranian health system, the portion of OOP payment and curative expenditure are expected to be controlled in the medium term. It is suggested that PHA should be examined annually in a more comprehensive manner to monitor

  16. Error awareness revisited: accumulation of multimodal evidence from central and autonomic nervous systems.

    Science.gov (United States)

    Wessel, Jan R; Danielmeier, Claudia; Ullsperger, Markus

    2011-10-01

    The differences between erroneous actions that are consciously perceived as errors and those that go unnoticed have recently become an issue in the field of performance monitoring. In EEG studies, error awareness has been suggested to influence the error positivity (Pe) of the response-locked event-related brain potential, a positive voltage deflection prominent approximately 300 msec after error commission, whereas the preceding error-related negativity (ERN) seemed to be unaffected by error awareness. Erroneous actions, in general, have been shown to promote several changes in ongoing autonomic nervous system (ANS) activity, yet such investigations have only rarely taken into account the question of subjective error awareness. In the first part of this study, heart rate, pupillometry, and EEG were recorded during an antisaccade task to measure autonomic arousal and activity of the CNS separately for perceived and unperceived errors. Contrary to our expectations, we observed differences in both Pe and ERN with respect to subjective error awareness. This was replicated in a second experiment, using a modified version of the same task. In line with our predictions, only perceived errors provoke the previously established post-error heart rate deceleration. Also, pupil size yields a more prominent dilatory effect after an erroneous saccade, which is also significantly larger for perceived than unperceived errors. On the basis of the ERP and ANS results as well as brain-behavior correlations, we suggest a novel interpretation of the implementation and emergence of error awareness in the brain. In our framework, several systems generate input signals (e.g., ERN, sensory input, proprioception) that influence the emergence of error awareness, which is then accumulated and presumably reflected in later potentials, such as the Pe.

  17. Chemistry of rain events in West Africa: evidence of dust and biogenic influence in convective systems

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    K. Desboeufs

    2010-10-01

    Full Text Available This paper documents the chemical composition of 7 rain events associated with mesoscale convective systems sampled at the supersite of Banizoumbou, Niger, during the first special observation periods (June–July 2006 of the African Monsoon Multidisciplinary Analyses (AMMA experiment. Time-resolved rain sampling was performed in order to discriminate the local dust scavenged at the beginning of rain event from the aerosol particles incorporated in the cloud at the end of the rain. The total elemental composition is dominated by Al, Si, Fe and Ca, indicating a high influence of dust and limited marine or anthropogenic contribution. After the aerosol wash-out, the elemental concentrations normalized to Al and the microscopic observations of diatoms, a tracer of the Bodélé depression, both indicate that the total elemental composition of rainwater is controlled by dust originating from North-eastern Saharan sources and probably incorporated in the convective cloud from the Harmattan layer. The low variability of the rain composition over the measurement period indicates a regional and temporal homogeneity of dust composition in the Harmattan layer. In the dissolved phase, the dominant anions are nitrate (NO3, sulphate (SO42− and chloride (Cl. However, between June and July we observe an increasing contribution of the organic anions (formate, acetate, oxalate associated with biogenic emissions to the total ion composition. These results confirm the large influence of biogenic emissions on the rain composition over Sahel during the wet season. The paper concludes on the capacity of mesoscale convective systems to carry simultaneously dust and biogenic compounds originating from different locations and depose them jointly. It also discusses the potential biogeochemical impact of such a phenomenon.

  18. A Novel Geographical Information Systems Framework to Characterize Photovoltaic Deployment in the UK: Initial Evidence

    Directory of Open Access Journals (Sweden)

    Paul Westacott

    2016-01-01

    Full Text Available Globally, deployment of grid-connected photovoltaics (PV has increased dramatically in recent years. The UK has seen rapid uptake reaching over 500,000 installations totalling 2.8 GWp by 2013. PV can be installed in different market segments (domestic rooftop, non-domestic rooftop and ground-mounted “solar-farms” covering a broad range of system sizes in a high number of locations. It is important to gain detailed understanding of what grid-connected PV deployment looks like (e.g., how it deployed across different geographic areas and market segments, and identify the major drivers behind it. This paper answers these questions by developing a novel geographical information systems (GIS-framework—the United Kingdom Photovoltaics Database (UKPVD—to analyze temporal and spatial PV deployment trends at high resolution across all market segments. Results show how PV deployment changed over time with the evolution of governmental PV policy support. Then spatial trends as function of local irradiation, rurality (as a proxy of building and population density and building footprint (as a proxy for roof-area are analyzed. We find in all market segments, PV deployment is strongly correlated with the level of policy support. Furthermore, all markets show a preference to deploy in rural areas and those with higher irradiation. Finally, local clustering of PV in all market segments was observed, revealing that PV is not spread evenly across areas. This work reveals the complex nature of PV deployment, both spatially and by market segment, reinforcing the need capture this through mapping.

  19. Social roles and performance of social-ecological systems: evidence from behavioral lab experiments

    Directory of Open Access Journals (Sweden)

    Irene Perez

    2015-09-01

    Full Text Available Social roles are thought to play an important role in determining the capacity for collective action in a community regarding the use of shared resources. Here we report on the results of a study using a behavioral experimental approach regarding the relationship between social roles and the performance of social-ecological systems. The computer-based irrigation experiment that was the basis of this study mimics the decisions faced by farmers in small-scale irrigation systems. In each of 20 rounds, which are analogous to growing seasons, participants face a two-stage commons dilemma. First they must decide how much to invest in the public infrastructure, e.g., canals and water diversion structures. Second, they must decide how much to extract from the water made available by that public infrastructure. Each round begins with a 60-second communication period before the players make their investment and extraction decisions. By analyzing the chat messages exchanged among participants during the communication stage of the experiment, we coded up to three roles per participant using the scheme of seven roles known to be important in the literature: leader, knowledge generator, connector, follower, moralist, enforcer, and observer. Our study supports the importance of certain social roles (e.g., connector previously highlighted by several case study analyses. However, using qualitative comparative analysis we found that none of the individual roles was sufficient for groups to succeed, i.e., to reach a certain level of group production. Instead, we found that a combination of at least five roles was necessary for success. In addition, in the context of upstream-downstream asymmetry, we observed a pattern in which social roles assumed by participants tended to differ by their positions. Although our work generated some interesting insights, further research is needed to determine how robust our findings are to different action situations, such as

  20. Ruthenium isotopic evidence for an inner Solar System origin of the late veneer.

    Science.gov (United States)

    Fischer-Gödde, Mario; Kleine, Thorsten

    2017-01-25

    The excess of highly siderophile elements in the Earth's mantle is thought to reflect the addition of primitive meteoritic material after core formation ceased. This 'late veneer' either comprises material remaining in the terrestrial planet region after the main stages of the Earth's accretion, or derives from more distant asteroidal or cometary sources. Distinguishing between these disparate origins is important because a late veneer consisting of carbonaceous chondrite-like asteroids or comets could be the principal source of the Earth's volatiles and water. Until now, however, a 'genetic' link between the late veneer and such volatile-rich materials has not been established or ruled out. Such genetic links can be determined using ruthenium (Ru) isotopes, because the Ru in the Earth's mantle predominantly derives from the late veneer, and because meteorites exhibit Ru isotope variations arising from the heterogeneous distribution of stellar-derived dust. Although Ru isotopic data and the correlation of Ru and molybdenum (Mo) isotope anomalies in meteorites were previously used to argue that the late veneer derives from the same type of inner Solar System material as do Earth's main building blocks, the Ru isotopic composition of carbonaceous chondrites has not been determined sufficiently well to rule them out as a source of the late veneer. Here we show that all chondrites, including carbonaceous chondrites, have Ru isotopic compositions distinct from that of the Earth's mantle. The Ru isotope anomalies increase from enstatite to ordinary to carbonaceous chondrites, demonstrating that material formed at greater heliocentric distance contains larger Ru isotope anomalies. Therefore, these data refute an outer Solar System origin for the late veneer and imply that the late veneer was not the primary source of volatiles and water on the Earth.

  1. Periodontal Systemic Connections-Novel Associations-A Review of the Evidence with Implications for Medical Practitioners.

    Science.gov (United States)

    Kalakonda, Butchibabu; Koppolu, Pradeep; Baroudi, Kusai; Mishra, Ashank

    2016-04-01

    Periodontal diseases, considered as inflammatory diseases have proved to have a spectrum of systemic implications. Earliest research has associated periodontal disease with common systemic aliments such as hypertension, diabetes, osteoporosis, rheumatoid arthritis to name a few. The evolution of advanced diagnostic aids let researchers make vast inroads in linking periodontal diseases to systemic diseases like Alzheimer's disease (AD) and even Schizophrenia. Our aim was to review and critically evaluate comprehensive literature and provide knowledge to medical practitioners on these associations so as to pave way for closer interactions between medical and dental practitioners in implementing better health care. Electronic databases such as PubMed, Google Scholar and Cochrane databases were used as source of the data for relevant studies published from 2005 up to 2015 with the following keywords, "'Periodontal disease", "systemic conditions", "periodontal disease and Alzheimer's", "Periodontal disease and Schizophrenia", "Periodontal disease and Psoriasis" and "Periodontal disease and erectile dysfunction". The evidence presented ascertains that a reasonable and modest association does exist between Periodontal disease and Alzheimer's, Schizophrenia, Erectile dysfunction, as well as Psoriasis and thus establishes periodontal disease as a potential risk factor.

  2. Aligning leadership across systems and organizations to develop a strategic climate for evidence-based practice implementation.

    Science.gov (United States)

    Aarons, Gregory A; Ehrhart, Mark G; Farahnak, Lauren R; Sklar, Marisa

    2014-01-01

    There has been a growing impetus to bridge the gap between basic science discovery, development of evidence-based practices (EBPs), and the availability and delivery of EBPs in order to improve the public health impact of such practices. To capitalize on factors that support implementation and sustainment of EBPs, it is important to consider that health care is delivered within the outer context of public health systems and the inner context of health care organizations and work groups. Leaders play a key role in determining the nature of system and organizational contexts. This article addresses the role of leadership and actions that leaders can take at and across levels in developing a strategic climate for EBP implementation within the outer (i.e., system) and inner (i.e., organization, work group) contexts of health care. Within the framework of Edgar Schein's "climate embedding mechanisms," we describe strategies that leaders at the system, organization, and work group levels can consider and apply to develop strategic climates that support the implementation and sustainment of EBP in health care and allied health care settings.

  3. Serological and Genetic Evidence for Altered Complement System Functionality in Systemic Lupus Erythematosus: Findings of the GAPAID Consortium.

    Science.gov (United States)

    Prechl, József; Papp, Krisztián; Hérincs, Zoltán; Péterfy, Hajna; Lóránd, Veronika; Szittner, Zoltán; Estonba, Andone; Rovero, Paolo; Paolini, Ilaria; Del Amo, Jokin; Uribarri, Maria; Alcaro, Maria Claudia; Ruiz-Larrañaga, Otsanda; Migliorini, Paola; Czirják, László

    2016-01-01

    Systemic lupus erythematosus is a chronic autoimmune disease with multifactorial ethiopathogenesis. The complement system is involved in both the early and late stages of disease development and organ damage. To better understand autoantibody mediated complement consumption we examined ex vivo immune complex formation on autoantigen arrays. We recruited patients with SLE (n = 211), with other systemic autoimmune diseases (n = 65) and non-autoimmune control subjects (n = 149). Standard clinical and laboratory data were collected and serum complement levels were determined. The genotype of SNP rs1143679 in the ITGAM gene was also determined. Ex vivo formation of immune complexes, with respect to IgM, IgG, complement C4 and C3 binding, was examined using a functional immunoassay on autoantigen microarray comprising nucleic acids, proteins and lipids. Complement consumption of nucleic acids increased upon binding of IgM and IgG even when serum complement levels were decreased due to consumption in SLE patients. A negative correlation between serum complement levels and ex vivo complement deposition on nucleic acid autoantigens is demonstrated. On the contrary, complement deposition on tested protein and lipid autoantigens showed positive correlation with C4 levels. Genetic analysis revealed that the non-synonymous variant rs1143679 in complement receptor type 3 is associated with an increased production of anti-dsDNA IgG antibodies. Notwithstanding, homozygous carriers of the previously reported susceptible allele (AA) had lower levels of dsDNA specific IgM among SLE patients. Both the non-synonymous variant rs1143679 and the high ratio of nucleic acid specific IgG/IgM were associated with multiple organ involvement. In summary, secondary complement deficiency in SLE does not impair opsonization of nucleic-acid-containing autoantigens but does affect other antigens and potentially other complement dependent processes. Dysfunction of the receptor recognizing complement

  4. Evidence for alternative quaternary structure in a bacterial Type III secretion system chaperone

    Directory of Open Access Journals (Sweden)

    Picking Wendy L

    2010-07-01

    Full Text Available Abstract Background Type III secretion systems are a common virulence mechanism in many Gram-negative bacterial pathogens. These systems use a nanomachine resembling a molecular needle and syringe to provide an energized conduit for the translocation of effector proteins from the bacterial cytoplasm to the host cell cytoplasm for the benefit of the pathogen. Prior to translocation specialized chaperones maintain proper effector protein conformation. The class II chaperone, Invasion plasmid gene (Ipg C, stabilizes two pore forming translocator proteins. IpgC exists as a functional dimer to facilitate the mutually exclusive binding of both translocators. Results In this study, we present the 3.3 Å crystal structure of an amino-terminally truncated form (residues 10-155, denoted IpgC10-155 of the class II chaperone IpgC from Shigella flexneri. Our structure demonstrates an alternative quaternary arrangement to that previously described for a carboxy-terminally truncated variant of IpgC (IpgC1-151. Specifically, we observe a rotationally-symmetric "head-to- head" dimerization interface that is far more similar to that previously described for SycD from Yersinia enterocolitica than to IpgC1-151. The IpgC structure presented here displays major differences in the amino terminal region, where extended coil-like structures are seen, as opposed to the short, ordered alpha helices and asymmetric dimerization interface seen within IpgC1-151. Despite these differences, however, both modes of dimerization support chaperone activity, as judged by a copurification assay with a recombinant form of the translocator protein, IpaB. Conclusions From primary to quaternary structure, these results presented here suggest that a symmetric dimerization interface is conserved across bacterial class II chaperones. In light of previous data which have described the structure and function of asymmetric dimerization, our results raise the possibility that class II

  5. Evidence for alternative quaternary structure in a bacterial Type III secretion system chaperone

    Energy Technology Data Exchange (ETDEWEB)

    Barta, Michael L.; Zhang, Lingling; Picking, Wendy L.; Geisbrecht, Brian V. (UMKC); (OKLU)

    2010-10-05

    Type III secretion systems are a common virulence mechanism in many Gram-negative bacterial pathogens. These systems use a nanomachine resembling a molecular needle and syringe to provide an energized conduit for the translocation of effector proteins from the bacterial cytoplasm to the host cell cytoplasm for the benefit of the pathogen. Prior to translocation specialized chaperones maintain proper effector protein conformation. The class II chaperone, Invasion plasmid gene (Ipg) C, stabilizes two pore forming translocator proteins. IpgC exists as a functional dimer to facilitate the mutually exclusive binding of both translocators. In this study, we present the 3.3 {angstrom} crystal structure of an amino-terminally truncated form (residues 10-155, denoted IpgC10-155) of the class II chaperone IpgC from Shigella flexneri. Our structure demonstrates an alternative quaternary arrangement to that previously described for a carboxy-terminally truncated variant of IpgC (IpgC{sup 1-151}). Specifically, we observe a rotationally-symmetric 'head-to-head' dimerization interface that is far more similar to that previously described for SycD from Yersinia enterocolitica than to IpgC1-151. The IpgC structure presented here displays major differences in the amino terminal region, where extended coil-like structures are seen, as opposed to the short, ordered alpha helices and asymmetric dimerization interface seen within IpgC{sup 1-151}. Despite these differences, however, both modes of dimerization support chaperone activity, as judged by a copurification assay with a recombinant form of the translocator protein, IpaB. Conclusions: From primary to quaternary structure, these results presented here suggest that a symmetric dimerization interface is conserved across bacterial class II chaperones. In light of previous data which have described the structure and function of asymmetric dimerization, our results raise the possibility that class II chaperones may

  6. Parasitic manipulation and neuroinflammation: Evidence from the system Microphallus papillorobustus (Trematoda - Gammarus (Crustacea

    Directory of Open Access Journals (Sweden)

    Thomas Frederic

    2010-04-01

    Full Text Available Abstract Background Neuropathological consequences of neuroinflammatory processes have been implicated in a wide range of diseases affecting the central nervous system (CNS. Glial cells, the resident immune cells of the CNS, respond to tissue injury by releasing proinflammatory cytokines and free radicals such as nitric oxide. We explored the possibility that neuroimmune responses are involved in parasitic manipulation of host behavior in a trematode-crustacean association. The cerebral larva of the flatworm Microphallus papillorobustus alters responses to environmental stimuli - and thus reflex pathways - in the crustacean Gammarus insensibilis, in a way that enhances predation of the crustacean by birds, definitive hosts of the parasite. Results Immunocytochemical experiments followed by confocal microscopy were performed to study the distribution of glutamine synthetase, a glial cell marker, and nitric oxide synthase in the brain of gammarids. Astrocyte-like glia and their processes were abundant at the surface of the parasites while levels of nitric oxide synthase were elevated at the host-parasite interface in the brain of gammarids harboring mature cerebral larvae and demonstrating altered behavior. Conclusion Taken together these results lend support to the neuroinflammation hypothesis whereby a chronic CNS specific immune response induced by the parasite plays a role in the disruption of neuromodulation, neuronal integrity, and behavior in infected hosts.

  7. Assessing the competitive conditions in the Italian banking system: some empirical evidence

    Directory of Open Access Journals (Sweden)

    Paolo Coccorese

    1998-06-01

    Full Text Available In the wake of European financial market integration, resulting from the elimination of controls on capital movements and the free access given to banks to other domestic markets within the EU, the Italian financial system has undergone a considerable transformation. In the aftermath of these new changes, however, has there been an increase in competition resulting in significant gains for consumers? Or rather, is unification alone, due to imperfections in financial markets, not enough to bring about stronger competition? Utilizing the Rosse-Panzar test, the author analyzes a sample of Italian banks from 1988-96 to evaluate the degree of competition in the industry. The findings suggest that the Italian banking industry operates under conditions of monopolistic competition and that European integration has yet to have a significant impact on industry conduct. However, the Author notes that due to the relative novelty of liberalization its long-term effect can not yet be known. Although the banking industry was far from equilibrium in the years examined, after the initiation of European integration there was a move towards it, however, it has yet to be attained.

  8. Spotlight on blisibimod and its potential in the treatment of systemic lupus erythematosus: evidence to date

    Science.gov (United States)

    Lenert, Aleksander; Niewold, Timothy B; Lenert, Petar

    2017-01-01

    B cells in general and BAFF (B cell activating factor of the tumor necrosis factor [TNF] family) in particular have been primary targets of recent clinical trials in systemic lupus erythematosus (SLE). In 2011, belimumab, a monoclonal antibody against BAFF, became the first biologic agent approved for the treatment of SLE. Follow-up studies have shown excellent long-term safety and tolerability of belimumab. In this review, we critically analyze blisibimod, a novel BAFF-neutralizing agent. In contrast to belimumab that only blocks soluble BAFF trimer but not soluble 60-mer or membrane BAFF, blisibimod blocks with high affinity all three forms of BAFF. Furthermore, blisibimod has a unique structure built on four high-affinity BAFF-binding peptides fused to the IgG1-Fc carrier. It was tested in phase I and II trials in SLE where it showed safety and tolerability. While it failed to reach the primary endpoint in a recent phase II trial, post hoc analysis demonstrated its efficacy in SLE patients with higher disease activity. Based on these results, blisibimod is currently undergoing phase III trials targeting this responder subpopulation of SLE patients. The advantage of blisibimod, compared to its competitors, lies in its higher avidity for BAFF, but a possible drawback may come from its immunogenic potential and the anticipated loss of efficacy over time. PMID:28331294

  9. Polarimetric evidence of a white dwarf pulsar in the binary system AR Scorpii

    Science.gov (United States)

    Buckley, D. A. H.; Meintjes, P. J.; Potter, S. B.; Marsh, T. R.; Gänsicke, B. T.

    2017-01-01

    The variable star AR Scorpii (AR Sco) was recently discovered to pulse in brightness every 1.97 min from ultraviolet wavelengths into the radio regime. The system is composed of a cool, low-mass star in a tight, 3.55-hour orbit with a more massive white dwarf. Here we report new optical observations of AR Sco that show strong linear polarization (up to 40%) that varies strongly and periodically on both the spin period of the white dwarf and the beat period between the spin and orbital period, as well as low-level (up to a few per cent) circular polarization. These observations support the notion that, similar to neutron-star pulsars, the pulsed luminosity of AR Sco is powered by the spin-down of the rapidly rotating white dwarf that is highly magnetized (up to 500 MG). The morphology of the modulated linear polarization is similar to that seen in the Crab pulsar, albeit with a more complex waveform owing to the presence of two periodic signals of similar frequency. Magnetic interactions between the two component stars, coupled with synchrotron radiation from the white dwarf, power the observed polarized and non-polarized emission. AR Sco is therefore the first example of a white dwarf pulsar.

  10. Evidence of arsenic release promoted by disinfection by-products within drinking-water distribution systems.

    Science.gov (United States)

    Andra, Syam S; Makris, Konstantinos C; Botsaris, George; Charisiadis, Pantelis; Kalyvas, Harris; Costa, Costas N

    2014-02-15

    Changes in disinfectant type could trigger a cascade of reactions releasing pipe-anchored metals/metalloids into finished water. However, the effect of pre-formed disinfection by-products on the release of sorbed contaminants (arsenic-As in particular) from drinking water distribution system pipe scales remains unexplored. A bench-scale study using a factorial experimental design was performed to evaluate the independent and interaction effects of trihalomethanes (TTHM) and haloacetic acids (HAA) on arsenic (As) release from either scales-only or scale-biofilm conglomerates (SBC) both anchored on asbestos/cement pipe coupons. A model biofilm (Pseudomonas aeruginosa) was allowed to grow on select pipe coupons prior experimentation. Either TTHM or HAA individual dosing did not promote As release from either scales only or SBC, detecting water. In the case of scales-only coupons, the combination of the highest spike level of TTHM and HAA significantly (pdisinfected finished water in pipe networks remains to be investigated in the field.

  11. Impact of Bisphenol A on the Cardiovascular System — Epidemiological and Experimental Evidence and Molecular Mechanisms

    Directory of Open Access Journals (Sweden)

    Xiaoqian Gao

    2014-08-01

    Full Text Available Bisphenol A (BPA is a ubiquitous plasticizing agent used in the manufacturing of polycarbonate plastics and epoxy resins. There is well-documented and broad human exposure to BPA. The potential risk that BPA poses to the human health has attracted much attention from regulatory agencies and the general public, and has been extensively studied. An emerging and rapidly growing area in the study of BPA’s toxicity is its impact on the cardiovascular (CV system. Recent epidemiological studies have shown that higher urinary BPA concentration in humans is associated with various types of CV diseases, including angina, hypertension, heart attack and coronary and peripheral arterial disease. Experimental studies have demonstrated that acute BPA exposure promotes the development of arrhythmias in female rodent hearts. Chronic exposure to BPA has been shown to result in cardiac remodeling, atherosclerosis, and altered blood pressure in rodents. The underlying mechanisms may involve alteration of cardiac Ca2+ handling, ion channel inhibition/activation, oxidative stress, and genome/transcriptome modifications. In this review, we discuss these recent findings that point to the potential CV toxicity of BPA, and highlight the knowledge gaps in this growing research area.

  12. Local Government Systems and Decentralization: Evidence from Pakistan’s Devolution Plan

    Directory of Open Access Journals (Sweden)

    Muhammad Shakil Ahmad

    2013-03-01

    Full Text Available The discourse of governance and development practitioners continues to embrace community participation and community empowerment as an elementary means of building local capacity for poverty reduction, development and change at the local level. This article is a review of the decentralization initiatives of local government systems after the announcement of the devolution plan in Pakistan. It evaluates the initiatives’ participatory methods to ascertain the extent to which they have improved the process of community development at the local level. This article also measures the impact of community empowerment on the sustainability of community-driven projects implemented under the decentralization initiative through community-based organizations known as Citizen Community Boards (CCBs. Document analysis and literature review methodologies were employed to gain further insight into the decentralization phenomenon in Pakistan. The results describe human development, improvements in community empowerment and the sustainability of local projects; however, the sense of community has yet to be translated into shared benefits for rural communities. The fundamental goal of decentralization seems to be elusive because only power was transferred to the local level, whereas there is little support for community capacity building and community access to resources and the elites still control the electoral process. It is argued that community development initiatives in Pakistan require continuous support from local governments to boost local rural economies. Likewise, community-local government participatory development strategies can lead to strong local ownership and empowerment in rural communities.

  13. Evidence of traffic-related pollutant control in soil-based sustainable urban drainage systems (SUDS).

    Science.gov (United States)

    Napier, F; Jefferies, C; Heal, K V; Fogg, P; Arcy, B J D; Clarke, R

    2009-01-01

    SUDS are being increasingly employed to control highway runoff and have the potential to protect groundwater and surface water quality by minimising the risks of both point and diffuse sources of pollution. While these systems are effective at retaining polluted solids by filtration and sedimentation processes, less is known of the detail of pollutant behaviour within SUDS structures. This paper reports on investigations carried out as part of a co-ordinated programme of controlled studies and field measurements at soft-engineered SUDS undertaken in the UK, observing the accumulation and behaviour of traffic-related heavy metals, oil and PAHs. The field data presented were collected from two extended detention basins serving the M74 motorway in the south-west of Scotland. Additional data were supplied from an experimental lysimeter soil core leaching study. Results show that basin design influences pollutant accumulation and behaviour in the basins. Management and/or control strategies are discussed for reducing the impact of traffic-related pollutants on the aqueous environment.

  14. Insulator–metal transition in a conservative system: An evidence for mobility coalescence in island silver films

    Indian Academy of Sciences (India)

    Manjunatha Pattabi

    2002-05-01

    Aging, which manifests itself as an irreversible increase in electrical resistance in island metal films is of considerable interest from both academic as well as applications point of view. Aging is attributed to various causes, oxidation of islands and mobility of islands followed by coalescence (mobility coalescence) being the main contenders. The effect of parameters like substrate temperature, substrate cleaning, residual gases in the vacuum chamber, ultrasonic vibration of the substrate, suggest that the mobility coalescence is responsible for the aging in island metal films. Electron microscopy studies show evidence for mobility of islands at high substrate temperatures. The comparison of aging data of island silver films deposited on glass substrates in ultra high vacuum and high vacuum suggests that the oxidation of islands, as being responsible for aging in these films, can be ruled out. Further, under certain conditions of deposition, island silver films exhibit a dramatic and drastic fall in electrical resistance, marking the insulator–metal transition. This interesting transition observed in a conservative system – after the stoppage of deposition of the film – is a clear evidence for mobility coalescence of islands even at room temperature. The sudden fall in resistance is preceded by fluctuations in resistance with time and the fluctuations are attributed to the making and breaking of the percolation path in the film

  15. Evidence of new risk genetic factor to systemic lupus erythematosus: the UBASH3A gene.

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    Lina-Marcela Diaz-Gallo

    Full Text Available The ubiquitin associated and Src-homology 3 (SH3 domain containing A (UBASH3a is a suppressor of T-cell receptor signaling, underscoring antigen presentation to T-cells as a critical shared mechanism of diseases pathogenesis. The aim of the present study was to determine whether the UBASH3a gene influence the susceptibility to systemic lupus erythematosus (SLE in Caucasian populations. We evaluated five UBASH3a polymorphisms (rs2277798, rs2277800, rs9976767, rs13048049 and rs17114930, using TaqMan® allelic discrimination assays, in a discovery cohort that included 906 SLE patients and 1165 healthy controls from Spain. The SNPs that exhibit statistical significance difference were evaluated in a German replication cohort of 360 SLE patients and 379 healthy controls. The case-control analysis in the Spanish population showed a significant association between the rs9976767 and SLE (Pc = 9.9E-03 OR = 1.21 95%CI = 1.07-1.37 and a trend of association for the rs2277798 analysis (P = 0.09 OR = 0.9 95%CI = 0.79-1.02. The replication in a German cohort and the meta-analysis confirmed that the rs9976767 (Pc = 0.02; Pc = 2.4E-04, for German cohort and meta-analysis, respectively and rs2277798 (Pc = 0.013; Pc = 4.7E-03, for German cohort and meta-analysis, respectively UBASH3a variants are susceptibility factors for SLE. Finally, a conditional regression analysis suggested that the most likely genetic variation responsible for the association was the rs9976767 polymorphism. Our results suggest that UBASH3a gene plays a role in the susceptibility to SLE. Moreover, our study indicates that UBASH3a can be considered as a common genetic factor in autoimmune diseases.

  16. Balance impairment in people with multiple sclerosis: preliminary evidence for the Balance Evaluation Systems Test.

    Science.gov (United States)

    Jacobs, Jesse V; Kasser, Susan L

    2012-07-01

    This study examined the validity of the Balance Evaluation Systems Test (BESTest) to identify balance impairments in people with multiple sclerosis (MS) by evaluating differences in BESTest performance between people with and without MS. We also assessed the BESTest's validity by correlation with objective measures of postural performance as well as with disease severity and fall status. Thirteen subjects with MS (Expanded Disability Status Scale; EDSS: 0-4.5) and 13 matched subjects without MS were evaluated on the BESTest, asked about fall history, and assessed by force plates and motion capture as they performed laboratory tasks of step initiation, forward leaning to the limits of stability, and postural responses to rotations of the support surface. Compared to subjects without MS, subjects with MS exhibited lower total BESTest scores (mean (95%) score for subjects with MS=91 (83-99); subjects without MS=105 (104-107)) as well as section scores pertaining to mechanical constraints, limits of stability, anticipatory postural adjustments, and gait. BESTest scores significantly correlated with objective laboratory measures of step velocity during step initiation (Pearson r(2)=0.48, P<0.01) as well as center-of-pressure displacements during both the leaning (Pearson r(2)=0.55, P<0.005) and postural-response tasks (Pearson r(2)=0.76, P<0.0001). BESTest total scores were 92% accurate to identify fallers and non-fallers, and BESTest scores significantly correlated with EDSS scores (Spearman's rho=0.85, P<0.0005). Thus, the BESTest provides a valid clinical assessment of balance impairments in people with MS.

  17. Control Problems in Distribution Channels: Empirical Evidence of Management Control Systems Contributions.

    Directory of Open Access Journals (Sweden)

    José M. Sánchez Vázqez

    2006-12-01

    Full Text Available As part of the supply chain, manufacturing firms are increasingly placing greater emphasis on the management of their outsourced distribution channels (DCs. However, the role that interorganizational Management Control Systems (MCS can play in managing DC problems is still not clearly understood. Through an exploratory case study, we show how intra-organizational control problems persist in an inter-organizational context, rooted in informational asymmetries and conflicts of interest and aggravated by interdependencies. Likewise, the case study illustrates the way in which MCS assists the manufacturing firm to communicate to its representatives what the organization wants from them, motivating them and transferring capabilities. Thus, MCS can help to complement and re-orientate inter-firm agreements and constitutes a key tool for managing DCs in a flexible way.Como parte de la cadena de suministros, las empresas productoras están poniendo mayor énfasis en la gestión de sus canales de distribución externalizados (DCs. Sin embargo, aún no existe una clara comprensión sobre el papel que los Sistemas de Control de Gestión inter-organizativos (MCS pueden desarrollar en la gestión de los problemas de los DCs. A través de un estudio de caso, se muestra cómo los problemas de control intra-organizativos persisten en un contexto inter-organizativo, causados por las asimetrías informativas y el conflicto de intereses, y agravándose por las interdependencias. Asimismo, se expone cómo los MCS ayudan a la empresa productora a comunicar a sus distribuidores lo que la organización desea de ellos, motivándolos y capacitándolos. De esta forma, los MCS pueden ayudar a completar y redirigir acuerdos entre firmas y constituir una herramienta clave en la gestión flexible de los DCs.

  18. Evidence from stable isotopes and 10Be for solar system formation triggered by a low-mass supernova

    Science.gov (United States)

    Banerjee, Projjwal; Qian, Yong-Zhong; Heger, Alexander; Haxton, W. C.

    2016-11-01

    About 4.6 billion years ago, some event disturbed a cloud of gas and dust, triggering the gravitational collapse that led to the formation of the solar system. A core-collapse supernova, whose shock wave is capable of compressing such a cloud, is an obvious candidate for the initiating event. This hypothesis can be tested because supernovae also produce telltale patterns of short-lived radionuclides, which would be preserved today as isotopic anomalies. Previous studies of the forensic evidence have been inconclusive, finding a pattern of isotopes differing from that produced in conventional supernova models. Here we argue that these difficulties either do not arise or are mitigated if the initiating supernova was a special type, low in mass and explosion energy. Key to our conclusion is the demonstration that short-lived 10Be can be readily synthesized in such supernovae by neutrino interactions, while anomalies in stable isotopes are suppressed.

  19. Evidence from stable isotopes and Be-10 for solar system formation triggered by a low-mass supernova

    CERN Document Server

    Banerjee, Projjwal; Heger, Alexander; Haxton, W C

    2016-01-01

    About 4.6 billion years ago, some event disturbed a cloud of gas and dust, triggering the gravitational collapse that led to the formation of the solar system. A core-collapse supernova, whose shock wave is capable of compressing such a cloud, is an obvious candidate for the initiating event. This hypothesis can be tested because supernovae also produce telltale patterns of short-lived radionuclides, which would be preserved today as isotopic anomalies. Previous studies of the forensic evidence have been inconclusive, finding a pattern of isotopes differing from that produced in conventional supernova models. Here we argue that these difficulties either do not arise or are mitigated if the initiating supernova was a special type, low in mass and explosion energy. Key to our conclusion is the demonstration that short-lived Be-10 can be readily synthesized in such supernovae by neutrino interactions, while anomalies in stable isotopes are suppressed.

  20. Evidence from stable isotopes and (10)Be for solar system formation triggered by a low-mass supernova.

    Science.gov (United States)

    Banerjee, Projjwal; Qian, Yong-Zhong; Heger, Alexander; Haxton, W C

    2016-11-22

    About 4.6 billion years ago, some event disturbed a cloud of gas and dust, triggering the gravitational collapse that led to the formation of the solar system. A core-collapse supernova, whose shock wave is capable of compressing such a cloud, is an obvious candidate for the initiating event. This hypothesis can be tested because supernovae also produce telltale patterns of short-lived radionuclides, which would be preserved today as isotopic anomalies. Previous studies of the forensic evidence have been inconclusive, finding a pattern of isotopes differing from that produced in conventional supernova models. Here we argue that these difficulties either do not arise or are mitigated if the initiating supernova was a special type, low in mass and explosion energy. Key to our conclusion is the demonstration that short-lived (10)Be can be readily synthesized in such supernovae by neutrino interactions, while anomalies in stable isotopes are suppressed.

  1. Phosphoenolpyruvate-dependent phosphorylation of sucrose by Clostridium tyrobutyricum ZJU 8235: evidence for the phosphotransferase transport system.

    Science.gov (United States)

    Jiang, Ling; Cai, Jin; Wang, Jufang; Liang, Shizhong; Xu, Zhinan; Yang, Shang-Tian

    2010-01-01

    The uptake and metabolism of sucrose, the major sugar in industrial cane molasses, by Clostridium tyrobutyricum ZJU 8235 was investigated and this study provided the first definitive evidence for phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) activity in butyric acid-producing bacteria. Glucose was utilized preferentially to sucrose when both substrates were present in the medium. The PEP-dependent sucrose: PTS was induced by growing C. tyrobutyricum on sucrose (but not glucose) as the sole carbon source. Extract fractionation and PTS reconstitution experiments revealed that both soluble and membrane components were required for bioactivity. Sucrose-6-phosphate hydrolase and fructokinase activities were also detected in sucrose-grown cultures. Based on these findings, a pathway of sucrose metabolism in this organism was proposed that includes the forming of sucrose-6-phosphate via the PTS and its further degradation into glucose-6-phosphate and fructose-6-phosphate.

  2. The Odivelas Limestone: evidence for a Middle Devonian reef system in western Ossa-Morena Zone (Portugal)

    Science.gov (United States)

    Machado, Gil; Hladil, Jindřich; Koptíková, Leona; Fonseca, Paulo E.; Rocha, Fernando T.; Galle, Arnošt

    2009-04-01

    The Odivelas Limestone constitutes one of the few records of Middle Devonian sedimentation in the western Ossa-Morena Zone. Although deformed and metamorphosed the limestones have an abundant fossil content which allows their positioning as late Eifelian/early Givetian in age and to relate the reef fauna with the typical Rhenish facies for the same time period. Magnetic susceptibility analysis was attempted and is in agreement with the biostratigraphy, but the limited extent of sections and the metamorphism precludes firm correlations. The field evidence, petrographic and geochemical analysis point to a close paleogeographical relation and dependence of the reef system on volcanic structures which are included in the Beja Igneous Complex. The age of part of the volcanic and sub-volcanic suite of this complex is thus constrained.

  3. Representation of complex vocalizations in the Lusitanian toadfish auditory system: evidence of fine temporal, frequency and amplitude discrimination

    Science.gov (United States)

    Vasconcelos, Raquel O.; Fonseca, Paulo J.; Amorim, M. Clara P.; Ladich, Friedrich

    2011-01-01

    Many fishes rely on their auditory skills to interpret crucial information about predators and prey, and to communicate intraspecifically. Few studies, however, have examined how complex natural sounds are perceived in fishes. We investigated the representation of conspecific mating and agonistic calls in the auditory system of the Lusitanian toadfish Halobatrachus didactylus, and analysed auditory responses to heterospecific signals from ecologically relevant species: a sympatric vocal fish (meagre Argyrosomus regius) and a potential predator (dolphin Tursiops truncatus). Using auditory evoked potential (AEP) recordings, we showed that both sexes can resolve fine features of conspecific calls. The toadfish auditory system was most sensitive to frequencies well represented in the conspecific vocalizations (namely the mating boatwhistle), and revealed a fine representation of duration and pulsed structure of agonistic and mating calls. Stimuli and corresponding AEP amplitudes were highly correlated, indicating an accurate encoding of amplitude modulation. Moreover, Lusitanian toadfish were able to detect T. truncatus foraging sounds and A. regius calls, although at higher amplitudes. We provide strong evidence that the auditory system of a vocal fish, lacking accessory hearing structures, is capable of resolving fine features of complex vocalizations that are probably important for intraspecific communication and other relevant stimuli from the auditory scene. PMID:20861044

  4. Positive spill-over effects of ART scale up on wider health systems development: evidence from Ethiopia and Malawi

    Directory of Open Access Journals (Sweden)

    Rasschaert Freya

    2011-07-01

    Full Text Available Abstract Background Global health initiatives have enabled the scale up of antiretroviral treatment (ART over recent years. The impact of HIV-specific funds and programmes on non-HIV-related health services and health systems in genera has been debated extensively. Drawing on evidence from Malawi and Ethiopia, this article analyses the effects of ART scale-up interventions on human resources policies, service delivery and general health outcomes, and explores how synergies can be maximized. Methods Data from Malawi and Ethiopia were compiled between 2004 and 2009 and between 2005 and 2009, respectively. We developed a conceptual health systems framework for the analysis. We used the major changes in human resources policies as an entry point to explore the wider health systems changes. Results In both countries, the need for an HIV response triggered an overhaul of human resources policies. As a result, the health workforce at health facility and community level was reinforced. The impact of this human resources trend was felt beyond the scale up of ART services; it also contributed to an overall increase in functional health facilities providing curative, mother and child health, and ART services. In addition to a significant increase in ART coverage, we observed a remarkable rise in user rates of non-HIV health services and an improvement in overall health outcomes. Conclusions Interventions aimed at the expansion of ART services and improvement of long-term retention of patients in ART care can have positive spill-over effects on the health system. The responses of Malawi and Ethiopia to their human resources crises was exceptional in many respects, and some of the lessons learnt can be useful in other contexts. The case studies show the feasibility of obtaining improved health outcomes beyond HIV through scaled-up ART interventions when these are part of a long-term, system-wide health plan supported by all decision makers and funders.

  5. Reflection Paper on a Ubiquitous English Vocabulary Learning System: Evidence of Active/Passive Attitude vs. Usefulness/Ease-of-Use

    Science.gov (United States)

    Lim, Jeff

    2013-01-01

    "A ubiquitous English vocabulary learning system: evidence of active/passive attitudes vs. usefulness/ease-of-use" introduces and develops "Ubiquitous English Vocabulary Learning" (UEFL) system. It introduces to the memorization using the video clips. According to their paper the video clip gives a better chance for students to…

  6. Systems for grading the quality of evidence and the strength of recommendations I: Critical appraisal of existing approaches The GRADE Working Group

    Directory of Open Access Journals (Sweden)

    Schünemann Holger

    2004-12-01

    Full Text Available Abstract Background A number of approaches have been used to grade levels of evidence and the strength of recommendations. The use of many different approaches detracts from one of the main reasons for having explicit approaches: to concisely characterise and communicate this information so that it can easily be understood and thereby help people make well-informed decisions. Our objective was to critically appraise six prominent systems for grading levels of evidence and the strength of recommendations as a basis for agreeing on characteristics of a common, sensible approach to grading levels of evidence and the strength of recommendations. Methods Six prominent systems for grading levels of evidence and strength of recommendations were selected and someone familiar with each system prepared a description of each of these. Twelve assessors independently evaluated each system based on twelve criteria to assess the sensibility of the different approaches. Systems used by 51 organisations were compared with these six approaches. Results There was poor agreement about the sensibility of the six systems. Only one of the systems was suitable for all four types of questions we considered (effectiveness, harm, diagnosis and prognosis. None of the systems was considered usable for all of the target groups we considered (professionals, patients and policy makers. The raters found low reproducibility of judgements made using all six systems. Systems used by 51 organisations that sponsor clinical practice guidelines included a number of minor variations of the six systems that we critically appraised. Conclusions All of the currently used approaches to grading levels of evidence and the strength of recommendations have important shortcomings.

  7. Social ecology of asthma: engaging stakeholders in integrating health behavior theories and practice-based evidence through systems mapping.

    Science.gov (United States)

    Gillen, Emily M; Hassmiller Lich, Kristen; Yeatts, Karin B; Hernandez, Michelle L; Smith, Timothy W; Lewis, Megan A

    2014-02-01

    This article describes a process for integrating health behavior and social science theories with practice-based insights using participatory systems thinking and diagramming methods largely inspired by system dynamics methods. This integration can help close the gap between research and practice in health education and health behavior by offering a systematic approach to bring together stakeholders across multiple domains. In this process we create a diagram using constructs from multiple health behavior theories at all levels of the social ecological framework as variables in causal loop diagrams. The goal of this process is to elucidate the reciprocal relationships between explanatory factors at various levels of the social ecological framework that render so many public health problems intractable. To illustrate, we detail a theory-based, replicable process for creating a qualitative diagram to enrich understanding of caregiver and provider behavior around adherence to pediatric asthma action plans. We describe how such diagramming can serve as the foundation for translating evidence into practice to address real-world challenges. Key insights gained include recognition of the complex, multilevel factors affecting whether, and how effectively, parents/caregivers and medical providers co-create an asthma action plan, and important "feedback" dynamics at play that can support or derail ongoing collaboration. Although this article applies this method to asthma action plan adherence in children, the method and resulting diagrams are applicable and adaptable to other health behaviors requiring continuous, daily action.

  8. Evidence of transfer by conjugation of type IV secretion system genes between Bartonella species and Rhizobium radiobacter in amoeba.

    Directory of Open Access Journals (Sweden)

    Watcharee Saisongkorh

    Full Text Available BACKGROUND: Bartonella species cospeciate with mammals and live within erythrocytes. Even in these specific niches, it has been recently suggested by bioinformatic analysis of full genome sequences that Lateral Gene Transfer (LGT may occur but this has never been demonstrated biologically. Here we describe the sequence of the B. rattaustraliani (AUST/NH4(T circular plasmid (pNH4 that encodes the tra cluster of the Type IV secretion system (T4SS and we eventually provide evidence that Bartonella species may conjugate and exchange this plasmid inside amoeba. PRINCIPAL FINDINGS: The T4SS of pNH4 is critical for intracellular viability of bacterial pathogens, exhibits bioinformatic evidence of LGT among bacteria living in phagocytic protists. For instance, 3 out of 4 T4SS encoding genes from pNH4 appear to be closely related to Rhizobiales, suggesting that gene exchange occurs between intracellular bacteria from mammals (bartonellae and plants (Rhizobiales. We show that B. rattaustraliani and Rhizobium radiobacter both survived within the amoeba Acanthamoeba polyphaga and can conjugate together. Our findings further support the hypothesis that tra genes might also move into and out of bacterial communities by conjugation, which might be the primary means of genomic evolution for intracellular adaptation by cross-talk of interchangeable genes between Bartonella species and plant pathogens. CONCLUSIONS: Based on this, we speculate that amoeba favor the transfer of genes as phagocytic protists, which allows for intraphagocytic survival and, as a consequence, promotes the creation of potential pathogenic organisms.

  9. Psychostimulant-Induced Testicular Toxicity in Mice: Evidence of Cocaine and Caffeine Effects on the Local Dopaminergic System.

    Directory of Open Access Journals (Sweden)

    Candela R González

    Full Text Available Several organ systems can be affected by psychostimulant toxicity. However, there is not sufficient evidence about the impact of psychostimulant intake on testicular physiology and catecholaminergic systems. The aim of the present study was to further explore potential toxic consequences of chronic exposure to cocaine, caffeine, and their combination on testicular physiology. Mice were injected with a 13-day chronic binge regimen of caffeine (3x5mg/kg, cocaine (3×10mg/kg, or combined administration. Mice treated with cocaine alone or combined with caffeine showed reduced volume of the seminiferous tubule associated to a reduction in the number of spermatogonia. Cocaine-only and combined treatments induced increased lipid peroxidation evaluated by TBARS assay and decreased glutathione peroxidase mRNA expression. Importantly, caffeine-cocaine combination potentiated the cocaine-induced germ cell loss, and induced pro-apoptotic BAX protein expression and diminished adenosine receptor A1 mRNA levels. We analyzed markers of dopaminergic function in the testis and detected the presence of tyrosine hydroxylase (TH in the cytoplasm of androgen-producing Leydig cells, but also in meiotic germs cells within seminiferous tubules. Moreover, using transgenic BAC-Drd1a-tdTomato and D2R-eGFP mice, we report for the first time the presence of dopamine receptors (DRs D1 and D2 in testicular mouse Leydig cells. Interestingly, the presence of DRD1 was also detected in the spermatogonia nearest the basal lamina of the seminiferous tubules, which did not show TH staining. We observed that psychostimulants induced downregulation of DRs mRNA expression and upregulation of TH protein expression in the testis. These findings suggest a potential role of the local dopaminergic system in psychostimulant-induced testicular pathology.

  10. Is there evidence for the use of art therapy in treatment of psychosomatic disorders, eating disorders and crisis? A comparative study of two different systems for evaluation.

    Science.gov (United States)

    Holmqvist, Gärd; Lundqvist Persson, Cristina

    2012-02-01

    A comparative study of two different systems for evaluation. Scandinavian Journal of Psychology 53, 47-53. As with any type of treatment the requirement for evidence based practice (EBP) has also affected art therapy (AT) when used as an intervention. This review evaluates the available evidence for using AT for psychosomatic disorders, eating disorders and crisis. The search in Cochrane, Best Practice, AMED, CINAHL, PION, PsycINFO and PubMed from 1987 until now resulted in a huge number of articles but only 32 articles met our criteria for evaluations. The articles were assessed with two evaluation systems, the GRADE system used by the Swedish Council on Health Technology Assessment (SBU) and the US Preventive Services Task Force (USPSTF/Task Force). When comparing the results we found that the GRADE evaluation system rejected the quality in 84% of the 32 studies and the USPSTF/Task Force 41% of these studies. An evidence base for AT was found only according to the criteria of USPSTF/Task Force. Hence, the evidence concept is not explicit, which means that effective treatments run a risk of not being implemented in health care. We suggest a broader view of what constitutes evidence in order to make it possible to include different types of research designs and methods.

  11. The HAT-P-13 Exoplanetary System: Evidence for Spin-Orbit Alignment and a Third Companion

    CERN Document Server

    Winn, Joshua N; Howard, Andrew W; Marcy, Geoffrey W; Bakos, Gaspar A; Hartman, Joel; Torres, Guillermo; Albrecht, Simon; Narita, Norio

    2010-01-01

    We present new radial-velocity measurements of HAT-P-13, a star with two previously known companions: a transiting giant planet "b" with an orbital period of 3 days, and a more massive object "c" on a 1.2 yr, highly eccentric orbit. For this system, dynamical considerations would lead to constraints on planet b's interior structure, if it could be shown that the orbits are coplanar and apsidally locked. By modeling the Rossiter-McLaughlin effect, we show that planet b's orbital angular momentum vector and the stellar spin vector are well-aligned on the sky (lambda = -0.9 +/- 8.5 deg), suggesting that the planetary orbits are also well-aligned. The refined orbital solution favors a slightly eccentric orbit for planet b (e = 0.0142_{-0.0044}^{+0.0052}), although it is not clear whether it is apsidally locked with c's orbit (\\Delta\\omega = 48_{-38}^{+25} deg). We find a long-term trend in the star's radial velocity and interpret it as evidence for an additional body "d", which may be another planet or a low-mass...

  12. A stellar prominence in the white dwarf/red dwarf binary QS Vir: evidence for a detached system

    CERN Document Server

    Parsons, S G; Gänsicke, B T; Tappert, C

    2010-01-01

    Using high resolution UVES spectra of the eclipsing Post Common Envelope Binary QS Vir we detect material along the line of sight to the white dwarf at orbital phase $\\phi=0.16$. We ascribe this to a stellar prominence originating from the M dwarf secondary star which passes in front of the white dwarf at this phase. This creates sharp absorption features in the hydrogen Balmer series and Ca II H and K lines. The small size of the white dwarf allows us to place tight constraints on the column density of hydrogen in the n=2 level of log_(10)(N_2) = 14.10 +/- 0.03 cm^(-2) and, assuming local thermodynamical equilibrium, the temperature of the prominence material of ~9000K. The prominence material is at least 1.5 stellar radii from the surface of the M dwarf. The location of the prominence is consistent with emission features previously interpreted as evidence for Roche lobe overflow in the system. We also detect Mg II 4481A absorption from the white dwarf. The width of the Mg II line indicates that the white dw...

  13. Drug-seeking behavior in an invertebrate system: evidence of morphine-induced reward, extinction and reinstatement in crayfish.

    Science.gov (United States)

    Nathaniel, Thomas I; Panksepp, Jaak; Huber, Robert

    2009-02-11

    Several lines of evidence suggest that exploring the neurochemical basis of reward in invertebrate species may provide clues for the fundamental behavioral and neurobiology underpinnings of drug addiction. How the presence of drug-sensitive reward relates to a decrease in drug-seeking behavior and reinstatement of drug-seeking behavior in invertebrate systems is not known. The present study of a conditioned place preference (CPP) paradigm in crayfish (Orconectes rusticus) explores morphine-induced reward, extinction and reinstatement. Repeated intra-circulatory infusions of 2.5 microg/g, 5.0 microg/g and 10.0 microg/g doses of morphine over 5 days serve as a reward when paired with a distinct visual or tactile environment. Morphine-induced CPP was extinguished after repeated saline injections for 5 days in the previously morphine-paired compartment. After the previously established CPP had been eliminated during the extinction phase, morphine-experienced crayfish were challenged with 2.5 microg/g, 5.0 microg/g and 10.0 microg/g, respectively. The priming injections of morphine reinstated CPP in all training doses, suggesting that morphine-induced CPP is unrelenting, and that with time, it can be reinstated by morphine following extinction in an invertebrate model just like in mammals. Together with other recent studies, this work demonstrates the advantage of using crayfish as an invertebrate animal model to investigate the basic biological processes that underline exposure to mammalian drugs of abuse.

  14. Evidence that a modified type IV pilus-like system powers gliding motility and polysaccharide secretion in filamentous cyanobacteria.

    Science.gov (United States)

    Khayatan, Behzad; Meeks, John C; Risser, Douglas D

    2015-12-01

    In filamentous cyanobacteria, the mechanism of gliding motility is undefined but posited to be driven by a polysaccharide secretion system known as the junctional pore complex (JPC). Recent evidence implies that the JPC is a modified type IV pilus-like structure encoded for in part by genes in the hps locus. To test this hypothesis, we conducted genetic, cytological and comparative genomics studies on hps and pil genes in Nostoc punctiforme, a species in which motility is restricted to transiently differentiated filaments called hormogonia. Inactivation of most hps and pil genes abolished motility and abolished or drastically reduced secretion of hormogonium polysaccharide, and the subcellular localization of several Pil proteins in motile hormogonia corresponds to the site of the junctional pore complex. The non-motile ΔhpsE-G strain, which lacks three glycosyltransferases that synthesize hormogonium polysaccharide, could be complemented to motility by the addition of medium conditioned by wild-type hormogonia. Based on this result, we speculate that secretion of hormogonium polysaccharide facilitates but does not provide the motive force for gliding. Both the Hps and Pil homologs characterized in this study are almost universally conserved among filamentous cyanobacteria, with the Hps homologs rarely found in unicellular strains. These results support the theory that Hps and Pil proteins compose the JPC, a type IV pilus-like nanomotor that drives motility and polysaccharide secretion in filamentous cyanobacteria.

  15. Health system barriers to strengthening vaccine-preventable disease surveillance and response in the context of decentralization: evidence from Georgia

    Directory of Open Access Journals (Sweden)

    Silvestre Eva A

    2006-07-01

    Full Text Available Abstract Background A critical challenge in the health sector in developing countries is to ensure the quality and effectiveness of surveillance and public health response in an environment of decentralization. In Georgia, a country where there has been extensive decentralization of public health responsibilities over the last decade, an intervention was recently piloted to strengthen district-level local vaccine-preventable disease surveillance and response activities through improved capacity to analyze and use routinely collected data. The purpose of the study is 1 to assess the effectiveness of the intervention on motivation and perceived capacity to analyze and use information at the district-level, and 2 to assess the role that individual- and system-level factors play in influencing the effectiveness of the intervention. Methods A pre-post quasi-experimental research design is used for the quantitative evaluation. Data come from a baseline and two follow-up surveys of district-level health staff in 12 intervention and 3 control Center of Public Health (CPH offices. These data were supplemented by record reviews in CPH offices as well as focus group discussions among CPH and health facility staff. Results The results of the study suggest that a number of expected improvements in perceived data availability and analysis occurred following the implementation of the intervention package, and that these improvements in analysis could be attributable to the intervention package. However, the study results also suggest that there exist several health systems barriers that constrained the effectiveness of the intervention in influencing the availability of data, analysis and response. Conclusion To strengthen surveillance and response systems in Georgia, as well as in other countries, donor, governments, and other stakeholders should consider how health systems factors influence investments to improve the availability of data, analysis, and

  16. Estrogen-triggered delays in mammary gland gene expression during the estrous cycle: evidence for a novel timing system.

    Science.gov (United States)

    Silberstein, Gary B; Van Horn, Katharine; Hrabeta-Robinson, Eva; Compton, Jennifer

    2006-08-01

    During the estrous cycle and beginning in estrus, the mammary gland undergoes pregnancy-like development that depends on transcriptional regulation by the estrogen and progesterone receptors (ER, PR) and Pax-2 as well as the action of the growth factors Wnt-4 and RANKL. In this report, we first describe the decay and delayed expression of ERalpha, PR, and Pax-2 proteins as well as depression of Wnt-4 and RANKL mRNA coincident with the strong estrogen surge in proestrus. In time-course studies using ovari-ectomized mice, a single estrogen injection replicated these delays and caused an 18 h delay in Wnt-4 expression. Molecular time-delay systems are at the core of cellular cycles, most notably the circadian clock, and depend on proteasome degradation of transcriptional regulators that exhibit dedicated timing functions. The cytoplasmic dynamics of these regulators govern delay duration through negative transcription/translation feedback loops. A proteasome inhibitor, PS-341, blocked estrogen-stimulated ERalpha, PR, and Pax-2 decay and proteasome chymotryptic activity, assayed using a fluorogenic substrate, was elevated in proestrus correlating with the depletion of the transcription factors. The 18-h delay in Wnt-4 induction corresponded to the turnover time of Pax-2 protein in the cytoplasm and was eliminated in Pax-2 knockout mammary tissue, demonstrating that Pax-2 has a unique timing function. The patterns of estrogen-triggered ERalpha, PR, and Pax-2 turnover were consistent with a negative transcriptional feedback. Retarding the expression of ERalpha, PR, and Pax-2 may optimize preparations for pregnancy by coordinating expression of critical receptors and transcription factors with rising estrogen and progesterone levels in estrus. The estrogen surge in proestrus has no defined mammotropic function. This study provides the first evidence that it is a synchronizing signal triggering proteasome-dependent turnover of mammary gland ERalpha, PR, and Pax-2. We

  17. Plutonic xenoliths from Martinique, Lesser Antilles: evidence for open system processes and reactive melt flow in island arc crust

    Science.gov (United States)

    Cooper, George F.; Davidson, Jon P.; Blundy, Jon D.

    2016-10-01

    The Lesser Antilles Volcanic Arc is remarkable for the abundance and variety of erupted plutonic xenoliths. These samples provide a window into the deeper crust and record a more protracted crystallisation history than is observed from lavas alone. We present a detailed petrological and in situ geochemical study of xenoliths from Martinique in order to establish their petrogenesis, pre-eruptive storage conditions and their contribution to construction of the sub-volcanic arc crust. The lavas from Martinique are controlled by crystal-liquid differentiation. Amphibole is rarely present in the erupted lavas, but it is a very common component in plutonic xenoliths, allowing us to directly test the involvement of amphibole in the petrogenesis of arc magmas. The plutonic xenoliths provide both textural and geochemical evidence of open system processes and crystal `cargos'. All xenoliths are plagioclase-bearing, with variable proportions of olivine, spinel, clinopyroxene, orthopyroxene and amphibole, commonly with interstitial melt. In Martinique, the sequence of crystallisation varies in sample type and differs from other islands of the Lesser Antilles arc. The compositional offset between plagioclase (~An90) and olivine (~Fo75), suggests crystallisation under high water contents and low pressures from an already fractionated liquid. Texturally, amphibole is either equant (crystallising early in the sequence) or interstitial (crystallising late). Interstitial amphibole is enriched in Ba and LREE compared with early crystallised amphibole and does not follow typical fractionation trends. Modelling of melt compositions indicates that a water-rich, plagioclase-undersaturated reactive melt or fluid percolated through a crystal mush, accompanied by the breakdown of clinopyroxene, and the crystallisation of amphibole. Geothermobarometry estimates and comparisons with experimental studies imply the majority of xenoliths formed in the mid-crust. Martinique cumulate xenoliths are

  18. Evidence for a role of orexin/hypocretin system in vestibular lesion-induced locomotor abnormalities in rats

    Directory of Open Access Journals (Sweden)

    Leilei Pan

    2016-07-01

    Full Text Available Vestibular damage can induce locomotor abnormalities in both animals and humans. Rodents with bilateral vestibular loss showed vestibular deficits syndrome such as circling, opisthotonus as well as locomotor and exploratory hyperactivity. Previous studies have investigated the changes in the dopamine system after vestibular loss, but the results are inconsistent and inconclusive. Numerous evidences indicate that the orexin system is implicated in central motor control. We hypothesized that orexin may be potentially involved in vestibular loss-induced motor disorders. In this study, we examined the effects of arsanilate- or 3, 3′-iminodipropionitrile (IDPN-induced vestibular lesion (AVL or IVL on the orexin-A (OXA labeling in rat hypothalamus using immunohistochemistry. The vestibular lesion-induced locomotor abnormalities were recorded and verified using a histamine H4 receptor antagonist JNJ7777120 (20 mg/kg, i.p.. The effects of the orexin receptor type 1 antagonist SB334867 (16 μg, i.c.v. on these behavior responses were also investigated. At 72 h post-AVL and IVL, animals exhibited vestibular deficit syndrome and locomotor hyperactivity in the home cages. These responses were significantly alleviated by JNJ7777120 which also eliminated AVL-induced increases in exploratory behavior in an open field. The numbers of OXA-labeled neurons in the hypothalamus were significantly increased in the AVL animals at 72 h post-AVL and in the IVL animals at 24, 48 and 72 h post-IVL. SB334867 significantly attenuated the vestibular deficit syndrome and locomotor hyperactivity at 72 h post-AVL and IVL. It also decreased exploratory behavior in the AVL animals. These results suggested that the alteration of OXA expression might contribute to locomotor abnormalities after acute vestibular lesion. The orexin receptors might be the potential therapeutic targets for vestibular disorders.

  19. Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees

    Science.gov (United States)

    Moser, Kathy L.; Neas, Barbara R.; Salmon, Jane E.; Yu, Hua; Gray-McGuire, Courtney; Asundi, Neeraj; Bruner, Gail R.; Fox, Jerome; Kelly, Jennifer; Henshall, Stephanie; Bacino, Debra; Dietz, Myron; Hogue, Robert; Koelsch, Gerald; Nightingale, Lydia; Shaver, Tim; Abdou, Nabih I.; Albert, Daniel A.; Carson, Craig; Petri, Michelle; Treadwell, Edward L.; James, Judith A.; Harley, John B.

    1998-01-01

    Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by production of autoantibodies against intracellular antigens including DNA, ribosomal P, Ro (SS-A), La (SS-B), and the spliceosome. Etiology is suspected to involve genetic and environmental factors. Evidence of genetic involvement includes: associations with HLA-DR3, HLA-DR2, Fcγ receptors (FcγR) IIA and IIIA, and hereditary complement component deficiencies, as well as familial aggregation, monozygotic twin concordance >20%, λs > 10, purported linkage at 1q41–42, and inbred mouse strains that consistently develop lupus. We have completed a genome scan in 94 extended multiplex pedigrees by using model-based linkage analysis. Potential [log10 of the odds for linkage (lod) > 2.0] SLE loci have been identified at chromosomes 1q41, 1q23, and 11q14–23 in African-Americans; 14q11, 4p15, 11q25, 2q32, 19q13, 6q26–27, and 12p12–11 in European-Americans; and 1q23, 13q32, 20q13, and 1q31 in all pedigrees combined. An effect for the FcγRIIA candidate polymorphism) at 1q23 (lod = 3.37 in African-Americans) is syntenic with linkage in a murine model of lupus. Sib-pair and multipoint nonparametric analyses also support linkage (P 2.0). Our results are consistent with the presumed complexity of genetic susceptibility to SLE and illustrate racial origin is likely to influence the specific nature of these genetic effects. PMID:9843982

  20. The Importance of Sample Return in Establishing Chemical Evidence for Life on Mars or Other Solar System Bodies

    Science.gov (United States)

    Glavin, D. P.; Conrad, P.; Dworkin, J. P.; Eigenbrode, J.; Mahaffy, P. R.

    2011-01-01

    The search for evidence of life on Mars and elsewhere will continue to be one of the primary goals of NASA s robotic exploration program over the next decade. NASA and ESA are currently planning a series of robotic missions to Mars with the goal of understanding its climate, resources, and potential for harboring past or present life. One key goal will be the search for chemical biomarkers including complex organic compounds important in life on Earth. These include amino acids, the monomer building blocks of proteins and enzymes, nucleobases and sugars which form the backbone of DNA and RNA, and lipids, the structural components of cell membranes. Many of these organic compounds can also be formed abiotically as demonstrated by their prevalence in carbonaceous meteorites [1], though, their molecular characteristics may distinguish a biological source [2]. It is possible that in situ instruments may reveal such characteristics, however, return of the right sample (i.e. one with biosignatures or having a high probability of biosignatures) to Earth would allow for more intensive laboratory studies using a broad array of powerful instrumentation for bulk characterization, molecular detection, isotopic and enantiomeric compositions, and spatially resolved chemistry that may be required for confirmation of extant or extinct Martian life. Here we will discuss the current analytical capabilities and strategies for the detection of organics on the Mars Science Laboratory (MSL) using the Sample Analysis at Mars (SAM) instrument suite and how sample return missions from Mars and other targets of astrobiological interest will help advance our understanding of chemical biosignatures in the solar system.

  1. Tackling malnutrition: a systematic review of 15-year research evidence from INDEPTH health and demographic surveillance systems

    Directory of Open Access Journals (Sweden)

    Samuelina S. Arthur

    2015-10-01

    Full Text Available Background: Nutrition is the intake of food in relation to the body's dietary needs. Malnutrition results from the intake of inadequate or excess food. This can lead to reduced immunity, increased susceptibility to disease, impaired physical and mental development, and reduced productivity. Objective: To perform a systematic review to assess research conducted by the International Network for the Demographic Evaluation of Populations and their Health (INDEPTH of health and demographic surveillance systems (HDSSs over a 15-year period on malnutrition, its determinants, the effects of under and over nutrition, and intervention research on malnutrition in low- and middle-income countries (LMICs. Methods: Relevant publication titles were uploaded onto the Zotero research tool from different databases (60% from PubMed. Using the keywords ‘nutrition’, ‘malnutrition’, ‘over and under nutrition’, we selected publications that were based only on data generated through the longitudinal HDSS platform. All titles and abstracts were screened to determine inclusion eligibility and full articles were independently assessed according to inclusion/exclusion criteria. For inclusion in this study, papers had to cover research on at least one of the following topics: the problem of malnutrition, its determinants, its effects, and intervention research on malnutrition. One hundred and forty eight papers were identified and reviewed, and 67 were selected for this study. Results: The INDEPTH research identified rising levels of overweight and obesity, sometimes in the same settings as under-nutrition. Urbanisation appears to be protective against under-nutrition, but it heightens the risk of obesity. Appropriately timed breastfeeding interventions were protective against malnutrition. Conclusions: Although INDEPTH has expanded the global knowledge base on nutrition, many questions remain unresolved. There is a need for more investment in nutrition research

  2. The Theory of Localist Representation and of a Purely Abstract Cognitive System: The Evidence from Cortical Columns, Category Cells, and Multisensory Neurons.

    Science.gov (United States)

    Roy, Asim

    2017-01-01

    The debate about representation in the brain and the nature of the cognitive system has been going on for decades now. This paper examines the neurophysiological evidence, primarily from single cell recordings, to get a better perspective on both the issues. After an initial review of some basic concepts, the paper reviews the data from single cell recordings - in cortical columns and of category-selective and multisensory neurons. In neuroscience, columns in the neocortex (cortical columns) are understood to be a basic functional/computational unit. The paper reviews the fundamental discoveries about the columnar organization and finds that it reveals a massively parallel search mechanism. This columnar organization could be the most extensive neurophysiological evidence for the widespread use of localist representation in the brain. The paper also reviews studies of category-selective cells. The evidence for category-selective cells reveals that localist representation is also used to encode complex abstract concepts at the highest levels of processing in the brain. A third major issue is the nature of the cognitive system in the brain and whether there is a form that is purely abstract and encoded by single cells. To provide evidence for a single-cell based purely abstract cognitive system, the paper reviews some of the findings related to multisensory cells. It appears that there is widespread usage of multisensory cells in the brain in the same areas where sensory processing takes place. Plus there is evidence for abstract modality invariant cells at higher levels of cortical processing. Overall, that reveals the existence of a purely abstract cognitive system in the brain. The paper also argues that since there is no evidence for dense distributed representation and since sparse representation is actually used to encode memories, there is actually no evidence for distributed representation in the brain. Overall, it appears that, at an abstract level, the

  3. The Theory of Localist Representation and of a Purely Abstract Cognitive System: The Evidence from Cortical Columns, Category Cells, and Multisensory Neurons

    Science.gov (United States)

    Roy, Asim

    2017-01-01

    The debate about representation in the brain and the nature of the cognitive system has been going on for decades now. This paper examines the neurophysiological evidence, primarily from single cell recordings, to get a better perspective on both the issues. After an initial review of some basic concepts, the paper reviews the data from single cell recordings – in cortical columns and of category-selective and multisensory neurons. In neuroscience, columns in the neocortex (cortical columns) are understood to be a basic functional/computational unit. The paper reviews the fundamental discoveries about the columnar organization and finds that it reveals a massively parallel search mechanism. This columnar organization could be the most extensive neurophysiological evidence for the widespread use of localist representation in the brain. The paper also reviews studies of category-selective cells. The evidence for category-selective cells reveals that localist representation is also used to encode complex abstract concepts at the highest levels of processing in the brain. A third major issue is the nature of the cognitive system in the brain and whether there is a form that is purely abstract and encoded by single cells. To provide evidence for a single-cell based purely abstract cognitive system, the paper reviews some of the findings related to multisensory cells. It appears that there is widespread usage of multisensory cells in the brain in the same areas where sensory processing takes place. Plus there is evidence for abstract modality invariant cells at higher levels of cortical processing. Overall, that reveals the existence of a purely abstract cognitive system in the brain. The paper also argues that since there is no evidence for dense distributed representation and since sparse representation is actually used to encode memories, there is actually no evidence for distributed representation in the brain. Overall, it appears that, at an abstract level, the

  4. Developmental Validation of the ParaDNA® Screening System - A presumptive test for the detection of DNA on forensic evidence items.

    Science.gov (United States)

    Dawnay, Nick; Stafford-Allen, Beccy; Moore, Dave; Blackman, Stephen; Rendell, Paul; Hanson, Erin K; Ballantyne, Jack; Kallifatidis, Beatrice; Mendel, Julian; Mills, DeEtta K; Nagy, Randy; Wells, Simon

    2014-07-01

    Current assessment of whether a forensic evidence item should be submitted for STR profiling is largely based on the personal experience of the Crime Scene Investigator (CSI) and the submissions policy of the law enforcement authority involved. While there are chemical tests that can infer the presence of DNA through the detection of biological stains, the process remains mostly subjective and leads to many samples being submitted that give no profile or not being submitted although DNA is present. The ParaDNA(®) Screening System was developed to address this issue. It consists of a sampling device, pre-loaded reaction plates and detection instrument. The test uses direct PCR with fluorescent HyBeacon™ detection of PCR amplicons to identify the presence and relative amount of DNA on an evidence item and also provides a gender identification result in approximately 75 minutes. This simple-to-use design allows objective data to be acquired by both DNA analyst and non-specialist personnel, to enable a more informed submission decision to be made. The developmental validation study described here tested the sensitivity, reproducibility, accuracy, inhibitor tolerance, and performance of the ParaDNA Screening System on a range of mock evidence items. The data collected demonstrates that the ParaDNA Screening System identifies the presence of DNA on a variety of evidence items including blood, saliva and touch DNA items.

  5. Magma system along fast-spreading centers controlled by ridge segmentation: Evidence from the northern Oman ophiolite

    Science.gov (United States)

    Miyashita, Sumio; Adachi, Yoshiko

    2013-04-01

    Mid-ocean ridges are segmented at various scales with a hierarchy, from the biggest 1st- order to the smallest 4th-order segments. These segment structures control magmatic processes beneath the mid-ocean ridges such as mantle upwelling, partial melting of the upper mantle, and magma delivery system to form the oceanic crust (Macdonald, 1998). However, systematic studies on the segment control for magmatic processes are rare at modern mid-ocean ridges due to the difficulty of obtaining in-situ samples from different crustal-lithospheric depths. Sampling at ocean floors is generally exclusively limited only to the surface (i.e. the seafloor). Furthermore, the samples obtained from the surface of the ocean floor may likely represent the products of off-axis magmatism (Kusano et al., 2012). Therefore, studies of ocean ridge segmentation in ophiolites provide important constraints for the magmatic processes beneath seafloor spreading centers, because the precise 3-D architecture of the upper mantle and the crust (all the way to the uppermost extrusive layer) and their lateral variations could be observed and investigated in ophiolites. We have studied the northern Oman ophiolite where a complete succession from the upper mantle peridotites to the uppermost extrusive rocks is well exposed. Miyashita et al. (2003), Adachi and Miyashita (2003) and Umino et al. (2003) proposed a segment structure in the northern Oman ophiolite; the Wadi Fizh area is regarded as a northward propagating tip of a mid-ocean ridge based on geological evidence (Adachi and Miyashita. 2003). On the other hand, the Wadi Thuqbah area, about 25 km south of Wadi Fizh, is regarded as a segment center based on the thickest Moho transition zone, well developed EW-trending lineations in the MTZ and layered gabbro, and the comparatively primitive compositions of the layered gabbros. Furthermore, the southern margin of the Hilti block (Salahi block), about 40 km south of Wadi Thuqbah, is inferred to be the

  6. Use of health systems and policy research evidence in the health policymaking in eastern Mediterranean countries: views and practices of researchers

    Directory of Open Access Journals (Sweden)

    El-Jardali Fadi

    2012-01-01

    Full Text Available Abstract Background Limited research exists on researchers' knowledge transfer and exchange (KTE in the eastern Mediterranean region (EMR. This multi-country study explores researchers' views and experiences regarding the role of health systems and policy research evidence in health policymaking in the EMR, including the factors that influence health policymaking, barriers and facilitators to the use of evidence, and the factors that increase researchers' engagement in KTE. Methods Researchers who published health systems and policy relevant research in 12 countries in the EMR (Bahrain, Egypt, Iran, Jordan, Lebanon, Libya, Morocco, Oman, Palestine, Sudan, Syria, and Yemen were surveyed. Descriptive analysis and Linear Mixed Regression Models were performed for quantitative sections and the simple thematic analysis approach was used for open-ended questions. Results A total of 238 researchers were asked to complete the survey (response rate 56%. Researchers indicated transferring results to other researchers (67.2% and policymakers in the government (40.5%. Less than one-quarter stated that they produced policy briefs (14.5%, disseminated messages that specified possible actions (24.4%, interacted with policymakers and stakeholders in priority-setting (16%, and involved them in their research (19.8%. Insufficient policy dialogue opportunities and collaboration between researchers and policymakers and stakeholders (67.9%, practical constraints to implementation (66%, non-receptive policy environment (61.3%, and politically sensitive findings (57.7% hindered the use of evidence. Factors that increase researchers' engagement in KTE activities in the region were associated with involving policymakers and stakeholders at various stages such as priority-setting exercises and provision of technical assistance. Conclusions Researchers in the EMR recognize the importance of using health systems evidence in health policymaking. Potential strategies to

  7. Climate for evidence-informed health systems: A print media analysis in 44 low- and middle-income countries that host knowledge-translation platforms

    Directory of Open Access Journals (Sweden)

    Lavis John N

    2011-02-01

    Full Text Available Abstract Background We conducted a print media analysis in 44 countries in Africa, the Americas, Asia, and the Eastern Mediterranean in order to understand one dimension of the climate for evidence-informed health systems and to provide a baseline for an evaluation of knowledge-translation platforms. Our focus was whether and how policymakers, stakeholders, and researchers talk in the media about three topics: policy priorities in the health sector, health research evidence, and policy dialogues regarding health issues. Methods We developed a search strategy consisting of three progressively more delimited phases. For each jurisdiction, we searched Major World Publications in LexisNexis Academic News for articles published in 2007, selected relevant articles using one set of general criteria and three sets of concept-specific criteria, and coded the selected articles to identify common themes. Second raters took part in the analysis of Lebanon and Malaysia to assess inter-rater reliability for article selection and coding. Results We identified approximately 5.5 and 5 times more articles describing health research evidence compared to the number of articles describing policy priorities and policy dialogues, respectively. Few articles describing health research evidence discussed systematic reviews (2% or health systems research (2%, and few of the policy dialogue articles discussed researcher involvement (9%. News coverage of these concepts was highly concentrated in several countries like China and Uganda, while few articles were found for many other jurisdictions. Kappa scores were acceptable and consistently greater than 0.60. Conclusions In many countries the print media, at least as captured in a global database, are largely silent about three topics central to evidence-informed health systems. These findings suggest the need for proactive-media engagement strategies.

  8. Long-distance travel and urban systems : Development of a theoretical and methodological framework and empirical evidence from Western Europe

    NARCIS (Netherlands)

    Limtanakool, N.

    2006-01-01

    It is evident in many countries worldwide that both the frequency and the distance of personal travel have grown concurrently with the proliferation of telecommunications that might substitute for travel. While the understanding of the determinants of long-distance travel is still limited in the lit

  9. Systems Thinking Tools for Improving Evidence-Based Practice: A Cross-Case Analysis of Two High School Leadership Teams

    Science.gov (United States)

    Kensler, Lisa A. W.; Reames, Ellen; Murray, John; Patrick, Lynne

    2012-01-01

    Teachers and administrators have access to large volumes of data but research suggests that they lack the skills to use data effectively for continuous school improvement. This study involved a cross-case analysis of two high school leadership teams' early stages of evidence-based practice development; differing forms of external support were…

  10. Evidence-Based Services in a Statewide Public Mental Health System: Do the Services Fit the Problems?

    Science.gov (United States)

    Schiffman, Jason; Becker, Kimberly D.; Daleiden, Eric L.

    2006-01-01

    This study examined the degree to which a literature review of evidence-based services identified services appropriate for the actual problems of youth involved in intensive public mental health services. The diagnostic profiles and specific intervention targets reported by treatment providers were coded to determine whether a relevant empirically…

  11. Ethics issues in scientific data and service provision: evidence and challenges for the European Plate Observing System (EPOS)

    Science.gov (United States)

    Cocco, Massimo; Freda, Carmela; Haslinger, Florian; Consortium, Epos

    2016-04-01

    Addressing Ethics issues is nowadays a relevant challenge for any initiative, program or project dealing with scientific data and products provision, access to services for scientific purposes and communication with different stakeholders, including society. This is corroborated by the evidence that Ethics has very high priority in EU funded research. Indeed, all the activities carried out under Horizon 2020 must comply with ethical principles and national, Union and international legislation. This implies that "For all activities funded by the European Union, Ethics is an integral part of research from beginning to end, and ethical compliance is seen as pivotal to achieve real research excellence." Here, we present the experience of EPOS, a public pan-European research infrastructure. EPOS aims at integrating data, data products, services and software (DDSS) for solid Earth science generated and provided by monitoring networks, observing systems and facilities belonging to European countries. EPOS fosters the integrated use of multidisciplinary solid Earth data to improve the understanding of physical and chemical processes controlling earthquakes, volcanic eruptions, tsunamis as well as those driving tectonics and surface dynamics. The EPOS integration plan will make significant contributions to understanding and mitigating geo-hazards, yielding data for hazard assessment, data products for engaging different stakeholders, and services for training, education and communication to society. Numerous national research infrastructures engaged in EPOS are deployed for the monitoring of areas prone to geo-hazards and for the surveillance of the national territory including areas used for exploiting geo-resources. The EPOS community is therefore already trained to provide services to public (civil defence agencies, local and national authorities) and private (petroleum industry, mining industry, geothermal companies, aviation security) stakeholders. Our ability to

  12. Evidence that the Agr-like quorum sensing system regulates the toxin production, cytotoxicity and pathogenicity of Clostridium perfringens type C isolate CN3685.

    Science.gov (United States)

    Vidal, Jorge E; Ma, Menglin; Saputo, Julian; Garcia, Jorge; Uzal, Francisco A; McClane, Bruce A

    2012-01-01

    Clostridium perfringens possesses at least two functional quorum sensing (QS) systems, i.e. an Agr-like system and a LuxS-dependent AI-2 system. Both of those QS systems can reportedly control in vitro toxin production by C. perfringens but their importance for virulence has not been evaluated. Therefore, the current study assessed whether these QS systems might regulate the pathogenicity of CN3685, a C. perfringens type C strain. Since type C isolates cause both haemorrhagic necrotic enteritis and fatal enterotoxemias (where toxins produced in the intestines are absorbed into the circulation to target other internal organs), the ability of isogenic agrB or luxS mutants to cause necrotizing enteritis in rabbit small intestinal loops or enterotoxemic lethality in mice was evaluated. Results obtained strongly suggest that the Agr-like QS system, but not the LuxS-dependent AI-2 QS system, is required for CN3685 to cause haemorrhagic necrotizing enteritis, apparently because the Agr-like system regulates the production of beta toxin, which is essential for causing this pathology. The Agr-like system, but not the LuxS-mediated AI-2 system, was also important for CN3685 to cause fatal enterotoxemia. These results provide the first direct evidence supporting a role for any QS system in clostridial infections.

  13. Similarities and differences of doctor-patient co-operated evidence-based medical record of treating digestive system diseases with integrative medicine compared with traditional medical records

    Institute of Scientific and Technical Information of China (English)

    Bo Li; Wen-Hong Shao; Yan-Da Li; Ying-Pan Zhao; Qing-Na Li; Zhao Yang; Hong-Cai Shang

    2016-01-01

    Objective: To establish the model of doctor-patient cooperated record, based on the concepts of narrative evidence-based medicine and related theories on Doctor-Patient Co-operated Evidence-Based Medical Record. Methods: We conducted a literature search from Pubmed, following the principles of narrative evidence-based medicine, and refer to the advice of experts of digestive system and EBM in both traditional Chinese medicine and Western medicine. Result: This research is a useful attempt to discuss the establishment of doctor-patient co-operated evidence-based medical record guided by narrative evidence-based medicine. Conclusion:Doctor-patient co-operated medical record can become a key factor of the curative effect evaluation methodology system of integrated therapy of tradition Chinese medicine and Western medicine on spleen and stomach diseases.%遵循叙事循证医学理念,咨询中西医消化内科及循证医学专家,凝练医患共建式病历的理论,建立医患共建式病历的范本,对比医患共建式病历与传统病历记录的不同,分析医患共建式病历的优缺点。思考与展望:医患共建式病历有可能成为中西医合作治疗脾胃病疗效评价方法学体系的一个要素。

  14. The Early Diagnosis of Boys and Girls in Academic Risk Using the Perceptual-Motor Diagnostic System: A Longitudinal Retrospective Study of Evidences of its Effectiveness

    OpenAIRE

    Emmanuel Herrera-González; Gerardo Alonso Araya-Vargas; Harry Fernández-Sagot; María Morera-Castro; Héctor Fonseca-Schmidt

    2015-01-01

    The main objective in this study is to evidence the efficiency of the Peques System as a useful tool to diagnose, at an early stage, possible difficulties which will affect the academic performance. In a 3-year longitudinal study, the Perceptual-Motor Diagnostic System (Peques) was applied to a sample of 149 participants (77 boys and 72 girls), who were beginning preschool education. Peques classified 38 children with a high risk to lose a year at primary school level. After a three-year foll...

  15. Evidences of validity of bender – gradual scoring system (B-SPG / Evidências de validade do bender – sistema de pontuação gradual (B-SPG

    Directory of Open Access Journals (Sweden)

    Ana Paula Porto Noronha

    2005-01-01

    Full Text Available This study aimed to gather evidences of validity for the Bender test – Gradual Scoring System (B-SPG, investigating developmental changes based on the relationships between its scores and the ages of the children. The study investigated 1052 children attending from pre-school to fourth grade of eight municipal and state public schools of Campinas (a city in the state of São Paulo, Brazil and the surrounding region. Ages ranged from six to ten years old, with an average of 8,35. The findings indicated that according to the increase of age, the B-SPG scores diminished, suggesting that the distortions progressively diminish as the children become older. Although other studies are suggested, the results presented here are consonant with researches that sought to establish that it is possible too find a maturational character among the figures of the test.

  16. The Collapse of the United States Banking System During the Great Depression, 1929 to 1933. New Archival Evidence

    Directory of Open Access Journals (Sweden)

    Gary Richardson

    2007-03-01

    Full Text Available During the Great Depression, one third of all banks in the United States failed. Scholarsdispute reason for their demise. This essay analyzes new evidence on the sources of bankdistress. The data demonstrates that contagion via correspondent networks and bank runspropagated the initial banking panics in the fall of 1930. As the depression deepened and assetvalues declined, insolvency loomed as the principal threat to depository institutions. Thesepatterns corroborate some and question other conjectures concerning the causes andconsequences of the financial crisis during the Great Contraction.

  17. Protocol for the Quick Clinical study: a randomised controlled trial to assess the impact of an online evidence retrieval system on decision-making in general practice

    Directory of Open Access Journals (Sweden)

    Kidd Michael R

    2006-08-01

    Full Text Available Abstract Background Online information retrieval systems have the potential to improve patient care but there are few comparative studies of the impact of online evidence on clinicians' decision-making behaviour in routine clinical work. Methods/design A randomized controlled parallel design is employed to assess the effectiveness of an online evidence retrieval system, Quick Clinical (QC in improving clinical decision-making processes in general practice. Eligible clinicians are randomised either to receive access or not to receive access to QC in their consulting rooms for 12 months. Participants complete pre- and post trial surveys. Two-hundred general practitioners are recruited. Participants must be registered to practice in Australia, have a computer with Internet access in their consulting room and use electronic prescribing. Clinicians planning to retire or move to another practice within 12 months or participating in any other clinical trial involving electronic extraction of prescriptions data are excluded from the study. The primary end-points for the study is clinician acceptance and use of QC and the resulting change in decision-making behaviour. The study will examine prescribing patterns related to frequently prescribed medications where there has been a recent significant shift in recommendations regarding their use based upon new evidence. Secondary outcome measures include self-reported changes in diagnosis, patient education, prescriptions written, investigations and referrals. Discussion A trial under experimental conditions is an effective way of examining the impact of using QC in routine general practice consultations.

  18. Perspective: NutriGrade: A Scoring System to Assess and Judge the Meta-Evidence of Randomized Controlled Trials and Cohort Studies in Nutrition Research.

    Science.gov (United States)

    Schwingshackl, Lukas; Knüppel, Sven; Schwedhelm, Carolina; Hoffmann, Georg; Missbach, Benjamin; Stelmach-Mardas, Marta; Dietrich, Stefan; Eichelmann, Fabian; Kontopanteils, Evangelos; Iqbal, Khalid; Aleksandrova, Krasimira; Lorkowski, Stefan; Leitzmann, Michael F; Kroke, Anja; Boeing, Heiner

    2016-11-01

    The objective of this study was to develop a scoring system (NutriGrade) to evaluate the quality of evidence of randomized controlled trial (RCT) and cohort study meta-analyses in nutrition research, building upon previous tools and expert recommendations. NutriGrade aims to assess the meta-evidence of an association or effect between different nutrition factors and outcomes, taking into account nutrition research-specific requirements not considered by other tools. In a pretest study, 6 randomly selected meta-analyses investigating diet-disease relations were evaluated with NutriGrade by 5 independent raters. After revision, NutriGrade was applied by the same raters to 30 randomly selected meta-analyses in the same thematic area. The reliability of ratings of NutriGrade items was calculated with the use of a multirater κ, and reliability of the total (summed scores) was calculated with the use of intraclass correlation coefficients (ICCs). The following categories for meta-evidence evaluation were established: high (8-10), moderate (6-7.99), low (4-5.99), and very low (0-3.99). The NutriGrade scoring system (maximum of 10 points) comprises the following items: 1) risk of bias, study quality, and study limitations, 2) precision, 3) heterogeneity, 4) directness, 5) publication bias, 6) funding bias, 7) study design, 8) effect size, and 9) dose-response. The NutriGrade score varied between 2.9 (very low meta-evidence) and 8.8 (high meta-evidence) for meta-analyses of RCTs, and it ranged between 3.1 and 8.8 for meta-analyses of cohort studies. The κ value of the ratings for each scoring item varied from 0.32 (95% CI: 0.22, 0.42) for risk of bias for cohort studies and 0.95 (95% CI: 0.91, 0.99) for study design, with a mean κ of 0.66 (95% CI: 0.53, 0.79). The ICC of the total score was 0.81 (95% CI: 0.69, 0.90). The NutriGrade scoring system showed good agreement and reliability. The initial findings regarding the performance of this newly established scoring system

  19. Perceived effectiveness of environmental decision support systems in participatory planning: Evidence from small groups of end-users

    NARCIS (Netherlands)

    Inman, D.; Blind, M.; Ribarova, I.; Krause, A.; Roosenschoon, O.R.; Kassahun, A.; Scholten, H.; Arampatzis, G.; Abrami, G.; McIntosh, B.S.; Jeffrey, P.

    2011-01-01

    The challenges associated with evaluating the effectiveness of environmental decision support systems (EDSS) based on the perceptions of only a small sample of end-users are well understood. Although methods adopted from Management Information Systems (MISs) evaluation research have benefited from r

  20. Dissemination of a Multilevel Evidence-Based System of Parenting Interventions with Broad Application to Child Welfare Populations

    Science.gov (United States)

    Prinz, Ron

    2009-01-01

    Parenting interventions are relevant to many touch points of the child welfare system. This paper describes a multilevel system of parenting interventions called "Triple P" that matches intervention intensities to families, builds on a strong scientific base, provides multiple access points for parents, and offers a destigmatized, cost-efficient…

  1. Towards Evidence-Based, Quality-Controlled Health Promotion: The Dutch Recognition System for Health Promotion Interventions

    Science.gov (United States)

    Brug, Johannes; van Dale, Djoeke; Lanting, Loes; Kremers, Stef; Veenhof, Cindy; Leurs, Mariken; van Yperen, Tom; Kok, Gerjo

    2010-01-01

    Registration or recognition systems for best-practice health promotion interventions may contribute to better quality assurance and control in health promotion practice. In the Netherlands, such a system has been developed and is being implemented aiming to provide policy makers and professionals with more information on the quality and…

  2. Integration of an Evidence Base into a Probabilistic Risk Assessment Model. The Integrated Medical Model Database: An Organized Evidence Base for Assessing In-Flight Crew Health Risk and System Design

    Science.gov (United States)

    Saile, Lynn; Lopez, Vilma; Bickham, Grandin; FreiredeCarvalho, Mary; Kerstman, Eric; Byrne, Vicky; Butler, Douglas; Myers, Jerry; Walton, Marlei

    2011-01-01

    This slide presentation reviews the Integrated Medical Model (IMM) database, which is an organized evidence base for assessing in-flight crew health risk. The database is a relational database accessible to many people. The database quantifies the model inputs by a ranking based on the highest value of the data as Level of Evidence (LOE) and the quality of evidence (QOE) score that provides an assessment of the evidence base for each medical condition. The IMM evidence base has already been able to provide invaluable information for designers, and for other uses.

  3. Is there a domain-general cognitive structuring system? Evidence from structural priming across music, math, action descriptions, and language.

    Science.gov (United States)

    Van de Cavey, Joris; Hartsuiker, Robert J

    2016-01-01

    Cognitive processing in many domains (e.g., sentence comprehension, music listening, and math solving) requires sequential information to be organized into an integrational structure. There appears to be some overlap in integrational processing across domains, as shown by cross-domain interference effects when for example linguistic and musical stimuli are jointly presented (Koelsch, Gunter, Wittfoth, & Sammler, 2005; Slevc, Rosenberg, & Patel, 2009). These findings support theories of overlapping resources for integrational processing across domains (cfr. SSIRH Patel, 2003; SWM, Kljajevic, 2010). However, there are some limitations to the studies mentioned above, such as the frequent use of unnaturalistic integrational difficulties. In recent years, the idea has risen that evidence for domain-generality in structural processing might also be yielded though priming paradigms (cfr. Scheepers, 2003). The rationale behind this is that integrational processing across domains regularly requires the processing of dependencies across short or long distances in the sequence, involving respectively less or more syntactic working memory resources (cfr. SWM, Kljajevic, 2010), and such processing decisions might persist over time. However, whereas recent studies have shown suggestive priming of integrational structure between language and arithmetics (though often dependent on arithmetic performance, cfr. Scheepers et al., 2011; Scheepers & Sturt, 2014), it remains to be investigated to what extent we can also find evidence for priming in other domains, such as music and action (cfr. SWM, Kljajevic, 2010). Experiment 1a showed structural priming from the processing of musical sequences onto the position in the sentence structure (early or late) to which a relative clause was attached in subsequent sentence completion. Importantly, Experiment 1b showed that a similar structural manipulation based on non-hierarchically ordered color sequences did not yield any priming effect

  4. Evidence-Based Development

    DEFF Research Database (Denmark)

    Hertzum, Morten; Simonsen, Jesper

    2004-01-01

    Systems development is replete with projects that represent substantial resource investments but result in systems that fail to meet users’ needs. Evidence-based development is an emerging idea intended to provide means for managing customer-vendor relationships and working systematically toward...... meeting customer needs. We are suggesting that the effects of the use of a system should play a prominent role in the contractual definition of IT projects and that contract fulfilment should be determined on the basis of evidence of these effects. Based on two ongoing studies of home-care management...

  5. Evidence-based librarianship: searching for the needed EBL evidence.

    Science.gov (United States)

    Eldredge, J D

    2000-01-01

    This paper discusses the challenges of finding evidence needed to implement Evidence-Based Librarianship (EBL). Focusing first on database coverage for three health sciences librarianship journals, the article examines the information contents of different databases. Strategies are needed to search for relevant evidence in the library literature via these databases, and the problems associated with searching the grey literature of librarianship. Database coverage, plausible search strategies, and the grey literature of library science all pose challenges to finding the needed research evidence for practicing EBL. Health sciences librarians need to ensure that systems are designed that can track and provide access to needed research evidence to support Evidence-Based Librarianship (EBL).

  6. Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system.

    Directory of Open Access Journals (Sweden)

    Nicholas C D'Amato

    Full Text Available Breast cancers with a basal-like gene signature are primarily triple-negative, frequently metastatic, and carry a poor prognosis. Basal-like breast cancers are enriched for markers of breast cancer stem cells as well as markers of epithelial-mesenchymal transition (EMT. While EMT is generally thought to be important in the process of metastasis, in vivo evidence of EMT in human disease remains rare. Here we report a novel model of human triple-negative breast cancer, the DKAT cell line, which was isolated from an aggressive, treatment-resistant triple-negative breast cancer that demonstrated morphological and biochemical evidence suggestive of phenotypic plasticity in the patient. The DKAT cell line displays a basal-like phenotype in vitro when cultured in serum-free media, and undergoes phenotypic changes consistent with EMT/MET in response to serum-containing media, a unique property among the breast cancer cell lines we tested. This EMT is marked by increased expression of the transcription factor Zeb1, and Zeb1 is required for the enhanced migratory ability of DKAT cells in the mesenchymal state. DKAT cells also express progenitor-cell markers, and single DKAT cells are able to generate tumorspheres containing both epithelial and mesenchymal cell types. In vivo, as few as ten DKAT cells are capable of forming xenograft tumors which display a range of epithelial and mesenchymal phenotypes. The DKAT model provides a novel model to study the molecular mechanisms regulating phenotypic plasticity and the aggressive biology of triple-negative breast cancers.

  7. A universal velocity dispersion profile for pressure supported systems: evidence for MONDian gravity across 12 orders of magnitude in mass

    CERN Document Server

    Hernandez, X; Cervantes-Sodi, B; Ibarra-Medel, H J; Lopez-Cruz, O

    2015-01-01

    For any MONDian extended theory of gravity where the rotation curves of spiral galaxies are explained through a change in physics rather than the hypothesis of dark matter, a generic dynamical behaviour is expected for pressure supported systems: an outer flattening of the velocity dispersion profile occurring at a characteristic radius, where both the amplitude of this flat velocity dispersion and the radius at which it appears are predicted to show distinct scalings with the total mass of the system. By carefully analysing dynamics of globular clusters, elliptical galaxies and galaxy clusters, we are able to significantly extend the astronomical scales over which MONDian gravity has been tested, from those of spiral galaxies, to the much larger range covered by pressure supported systems. We show that a universal projected velocity dispersion profile accurately describes various classes of pressure supported systems, and further, that the expectations of extended gravity are met, across twelve orders of mag...

  8. No evidence for a putative involvement of platelet-activating factor in systemic lupus erythematosus without active nephritis

    Directory of Open Access Journals (Sweden)

    Yves Denizot

    2003-01-01

    Full Text Available Background: Platelet-activating factor (PAF seems to be implicated in systemic lupus erythematosus (SLE patients with associated renal diseases.Aims: In this study, we ensured the role of PAF in SLE patients without renal complications.

  9. Nurse staffing and system integration and change indicators in acute care hospitals: evidence from a balanced scorecard.

    Science.gov (United States)

    McGillis Hall, Linda; Peterson, Jessica; Baker, G Ross; Brown, Adalsteinn D; Pink, George H; McKillop, Ian; Daniel, Imtiaz; Pedersen, Cheryl

    2008-01-01

    This study examined relationships between financial indicators for nurse staffing and organizational system integration and change indicators. These indicators, along with hospital location and type, were examined in relation to the nursing financial indicators. Results showed that different indicators predicted each of the outcome variables. Nursing care hours were predicted by the hospital type, geographic location, and the system. Both nursing and patient care hours were significantly related to dissemination and benchmarking of clinical data.

  10. Electoral Systems and the Influence of the Median Voter: Quasi-Experimental Evidence from popular and parliamentary votes

    OpenAIRE

    2010-01-01

    When moving from a plurality rule to a proportional system, members of national parliament have more incentives to diverge from the median voter's preferences. We match voting behavior concerning legislative proposals of Swiss members of parliament with real referenda outcomes on the same issues for the years 1996 to 2009. This quasi-experimental data allows us to identify whether differences in electoral systems induce members of parliament to diverge from the choices of the median voter. Em...

  11. Embracing a systems perspective of innovation – Evidence from Ireland on the use of innovation links, 1991 to 2002

    OpenAIRE

    Hewitt-Dundas, Nola; Leonard, Ciara

    2005-01-01

    Conceptual perspectives on the innovation process have moved dramatically in the past decade from a linear model of the innovation process to one based on an evolutionary or systems perspective of innovation. This has also been referred to as moving from a closed to an open innovation paradigm. In this systems perspective, innovation networks are critical with innovation being driven by interaction and co-operation between firms and other organisations. Empirical research has supported this p...

  12. THE EFFECT OF E-COMMERCE ON MALAYSIAN TAX SYSTEM: AN EMPIRICAL EVIDENCE FROM ACADEMICIANS AND MALAYSIAN TAX PRACTITIONERS

    OpenAIRE

    Mohd Rizal Palil

    2004-01-01

    The explosion of information technology (IT) nowadays has created new phenomena in shopping activities. Consumers can easily buy products via Internet. Within a minute, the products will be delivered instantly and accurately. This scenario is known as e-commerce. The emergence of e-commerce affects consumers' shopping behavior as well as taxation system. The objective of this research is to reveal the effects of e-commerce upon Malaysian taxation system by emphasizing in scope of charge 'deri...

  13. The impact of cyber crime in the criminal evidence system%论网络犯罪对刑事证据制度的冲击

    Institute of Scientific and Technical Information of China (English)

    李娜; 谢志杰; 邓宝征

    2012-01-01

    本文将结合网络犯罪的发展态势,针对刑事法律在网络犯罪狂潮所面临的挑战,分析、探索刑事证据制度如何应对网络犯罪的冲击。%This will combine the development trend of cyber crime,the challenges faced by the criminal law in cyber crime spree,analyze,and explore the criminal evidence system how to deal with the impact of cyber crime.

  14. Evaluation of WGA and Concanavalin A (Con A lectin as biomarkers of hepatosplenic schistosomiasis in human biopsies with no evidence of egg-granuloma system

    Directory of Open Access Journals (Sweden)

    Moacyr Jesus Barreto de Melo Rêgo

    2013-06-01

    Full Text Available Introduction: Colonic lesions are predominant in patients with schistosomiasis. However, carbohydrate alterations in colonic schistosomiasis remain unclear. Lectin-ligands allow us to identify changes in the saccharide patterns of cells. Methods: Biopsies of descending and rectosigmoid colon of patients were submitted to WGA and Con A lectin histochemistry. Results: WGA stained stroma and gland cells of descending colon and rectosigmoid tissues in a granular strong cytoplasmatic pattern in schistosomiasis specimens differing from normal control and Con A failing to recognize all samples analyzed. Conclusions: WGA ligands are expressed differently in patients with hepatosplenic schistosomiasis and no evidence of egg-granuloma system.

  15. National systems of innovation: determinants and industrial policy measures, empirical evidence for OECD; Sistemas nacionales de innovacion: determinantes y acciones de politica industrial. Evidencia empirica para la OCDE

    Energy Technology Data Exchange (ETDEWEB)

    Hervas, J. L.; Rojas, R.; Sempere, F.; Albors, J.

    2012-11-01

    The paper presents an attempt to tackle the main gaps in the national innovation systems (NIS) literature: the problem specifying the boundaries of the NIS and the lack of connection between theory and empirics. For this purpose, the paper uses 55 countries as sample and constructs an NIS index based on a factor analysis of 28 variables. Empirical evidence shows that a firm's strategies, technology infrastructure, government governance, education and linkages are the main components of the NIS. The implications are important for policy-makers and the academia. (Author) 49 refs.

  16. New Evidence on Causal Relationship between Approximate Number System (ANS) Acuity and Arithmetic Ability in Elementary-School Students: A Longitudinal Cross-Lagged Analysis.

    Science.gov (United States)

    He, Yunfeng; Zhou, Xinlin; Shi, Dexin; Song, Hairong; Zhang, Hui; Shi, Jiannong

    2016-01-01

    Approximate number system (ANS) acuity and mathematical ability have been found to be closely associated in recent studies. However, whether and how these two measures are causally related still remain less addressed. There are two hypotheses about the possible causal relationship: ANS acuity influences mathematical performances, or access to math education sharpens ANS acuity. Evidences in support of both hypotheses have been reported, but these two hypotheses have never been tested simultaneously. Therefore, questions still remain whether only one-direction or reciprocal causal relationships existed in the association. In this work, we provided a new evidence on the causal relationship between ANS acuity and arithmetic ability. ANS acuity and mathematical ability of elementary-school students were measured sequentially at three time points within one year, and all possible causal directions were evaluated simultaneously using cross-lagged regression analysis. The results show that ANS acuity influences later arithmetic ability while the reverse causal direction was not supported. Our finding adds a strong evidence to the causal association between ANS acuity and mathematical ability, and also has important implications for educational intervention designed to train ANS acuity and thereby promote mathematical ability.

  17. Correlates among cognitive beliefs, EBP implementation, organizational culture, cohesion and job satisfaction in evidence-based practice mentors from a community hospital system.

    Science.gov (United States)

    Melnyk, Bernadette Mazurek; Fineout-Overholt, Ellen; Giggleman, Martha; Cruz, Ron

    2010-01-01

    Evidence from research and outcomes management projects strongly supports the use of evidence-based practice (EBP) in improving quality of health care and patient outcomes as well as reducing hospital costs. In addition, published anecdotal reports have indicated that clinicians who use an evidence-based approach to care and practice in cultures that support EBP feel more empowered and satisfied in their roles. However, research is lacking that has specifically examined the relationships among beliefs about and implementation of EBP by hospital staff, organizational culture for EBP, group cohesion and job satisfaction. Therefore, the purpose of this descriptive correlational study was to examine the relationships among these variables in 58 health professionals, prior to their participation in a 12-month EBP mentorship program as part of implementing the Advancing Research and Clinical practice through close Collaboration (ARCC) Model in a community hospital system. Findings indicated that participants' EBP beliefs were significantly correlated with perceived organizational culture for EBP, the extent to which they implemented EBP, group cohesion, and job satisfaction. Organizational culture for EBP was significantly and positively related to EBP beliefs and EBP implementation. Findings support the need for hospitals to establish cultures that support EBP and to implement strategies to strengthen individuals' cognitive beliefs about the value of EBP and their ability to implement it for the ultimate purpose of improving quality of care and enhancing job satisfaction.

  18. Correlation between Systemic Arterial Hypertension and Bone Morphogenetic Protein-2 in Central Obese Non-Diabetic Men with Evidence of Coronary Artery Calcification

    Directory of Open Access Journals (Sweden)

    Antonia Anna Lukito

    2011-12-01

    Full Text Available BACKGROUND: Previous studies have confirmed separately the relationship between obesity, insulin-resistance, hypertension and bone morphogenetic protein-2 (BMP-2 with coronary artery calcification, a parameter of subclinical atherosclerosis. It was also reported that BMPs may function as proinflammatory, prohypertensive and proatherogenic mediators. The study aimed to assess the correlation between systemic hypertension and BMP-2 plasma concentration in central-obese non-diabetic men with evidence of coronary artery calcification. METHODS: This was a cross sectional study on 60 central-obese non-diabetic men, of an average age of 55.2 years, with evidence of coronary calcification, who came for health check-up and met the inclusion criteria consecutively as defined by waist circumference >90 cm and fasting blood glucose <126 mg/dL. Coronary calcification was defined by coronary artery calcium (CAC score ≥10 Agatson-unit Dual Source 64 slice CT scan. RESULTS: There is positive correlation between hypertension and BMP-2 in central-obese non-diabetic men with evidence of coronary artery calcification. BMP-2 plasma concentration was higher in the hypertensive subjects. The correlation was stronger in younger (<55 years old subjects and subjects with insulin-resitance. KEYWORDS: hypertension, BMP-2, coronary calcification, central obesity, age, insulin resistance.

  19. Extinct 129I in Halite from a Primitive Meteorite: Evidence for Evaporite Formation in the Early Solar System

    Science.gov (United States)

    Whitby, James; Burgess, Ray; Turner, Grenville; Gilmour, Jamie; Bridges, John

    2000-06-01

    Halite crystals from the Zag H3-6 chondrite contain essentially pure (monoisotopic) xenon-129 (129Xe) produced in the early history of the solar system by the decay of short-lived iodine-129 (129I) (half-life = 15.7 million years). Correlated release of 129Xe and 128Xe, produced artificially from 127I by neutron irradiation, corresponds to an initial (129I/127I) ratio of (1.35 +/- 0.05) × 10-4, close to the most primitive early solar system value. If the 129Xe was produced by in situ decay, then the halite formed from an aqueous fluid within 2 million years of the oldest known solar system minerals.

  20. The Role of Nature and Nurture for Individual Differences in Primary Emotional Systems: Evidence from a Twin Study.

    Directory of Open Access Journals (Sweden)

    Christian Montag

    Full Text Available The present study investigated for the first time the relative importance of genetics and environment on individual differences in primary emotionality as measured with the Affective Neuroscience Personality Scales (ANPS by means of a twin-sibling study design. In N = 795 participants (n = 303 monozygotic twins, n = 172 dizygotic twins and n = 267 non-twin full siblings, moderate to strong influences of genetics on individual differences in these emotional systems are observed. Lowest heritability estimates are presented for the SEEKING system (33% and highest for the PLAY system (69%. Further, multivariate genetic modeling was applied to the data showing that associations among the six ANPS scales were influences by both, a genetic as well as an environmental overlap between them. In sum, the study underlines the usefulness of the ANPS for biologically oriented personality psychology research.

  1. Joint impact of ERP systems and non financial performance indicators on corporate financial performance: Evidence from French listed companies

    Directory of Open Access Journals (Sweden)

    Ahmed Kouki

    2015-01-01

    Full Text Available This paper aims to examine the joint impact of Enterprise Resource Planning systems (ERP systems and Non Financial Performance Indicators (NFPI on corporate financial performance. Our study is based on a comparative analysis between firms that adopt ERP only, firms that use NFPI only and firms that combining both strategies (ERP and NFPI during the period from 2001 to 2006.The implementation process remains highly uncertain. In fact, the use of Non Financial performance indicators is an important determinant of corporate financial performance. At the operational level, combining ERP systems with NFPI reflects a long-term business strategy to improve business process. In summary, the ERP and NFPI literatures demonstrate the vital importance of aligning business process, information technologies and key performance indicators with the strategic objectives of the firm. Results support the hypothesis in which firms that combining ERP and NFPI have significantly higher ROA than either ERP-only or NFPI-only firms.

  2. The Impact of Supervisory Board Composition on CSR Reporting. Evidence from the German Two-Tier System

    Directory of Open Access Journals (Sweden)

    Dominik Dienes

    2016-01-01

    Full Text Available Corporate social responsibility (CSR reporting is becoming increasingly relevant in light of modern corporate governance. There is growing activity among empirical research in one-tier systems that considers the link between board composition and CSR reporting. This study is the first of its kind on the German two-tier system with special regard for the supervisory board. We analyze gender diversity, expertise, the presence of former managers, frequency of meetings, and the size of the supervisory board. Our multiple regressions indicate that gender diversity has a positive impact on CSR disclosure intensity, which is in line with prior studies on one-tier systems. Our findings have implications for both users and public policy and suggest that current European corporate governance regulations could help to increase the decision usefulness of CSR reporting.

  3. Patient and provider perspectives on quality and health system effectiveness in a transition economy: evidence from Ukraine.

    Science.gov (United States)

    Luck, J; Peabody, J W; DeMaria, L M; Alvarado, C S; Menon, R

    2014-08-01

    Facing a severe population health crisis due to noncommunicable diseases, Ukraine and other former Soviet republics and Eastern European countries have a pressing need for more effective health systems. Policies to enhance health system effectiveness should consider the perspectives of different stakeholder groups, including providers as well as patients. In addition, policies that directly target the quality of clinical care should be based on objective performance measures. In 2009 and 2010 we conducted a coordinated series of household and facility-level surveys to capture the perspectives of Ukrainian household members, outpatient clinic patients, and physicians regarding the country's health system overall, as well as the quality, access, and affordability of health care. We objectively measured the quality of care for heart failure and chronic obstructive pulmonary disease using CPV(®) vignettes. There was broad agreement among household respondents (79%) and physicians (95%) that Ukraine's health system should be reformed. CPV(®) results indicate that the quality of care for common noncommunicable diseases is poor in all regions of the country and in hospitals as well as polyclinics. However, perspectives about the quality of care differ, with household respondents seeing quality as a serious concern, clinic patients having more positive perceptions, and physicians not viewing quality as a reform priority. All stakeholder groups viewed affordability as a problem. These findings have several implications for policies to enhance health system effectiveness. The shared desire for health system reform among all stakeholder groups provides a basis for action in Ukraine. Improving quality, strengthening primary care, and enhancing affordability should be major goals of new health policies. Policies to improve quality directly, such as pay-for-performance, would be mutually reinforcing with purchasing reforms such as transparent payment mechanisms. Such policies

  4. Informing energy and climate policies using energy systems models insights from scenario analysis increasing the evidence base

    CERN Document Server

    Giannakidis, George; Ó Gallachóir, Brian; Tosato, GianCarlo

    2015-01-01

    This book highlights how energy-system models are used to underpin and support energy and climate mitigation policy decisions at national, multi-country and global levels. It brings together, for the first time in one volume, a range of methodological approaches and case studies of good modeling practice on a national and international scale from the IEA-ETSAP energy technology initiative. It provides insights for the reader into the rich and varied applications of energy-system models and the underlying methodologies and policy questions they can address. The book demonstrates how these mode

  5. Next-generation network evidence collection system%下一代网络取证系统

    Institute of Scientific and Technical Information of China (English)

    陈华; 许能

    2011-01-01

    High speed network challenges network forensics with huge data. The paper points out the restrictions of technology, then puts forward the next generation network forensic system. The system suits new demand,%高速网络环境下,网络取证面临着大规模、大数据分析的严峻挑战,文中指出目前技术上的限制,同时提出应对新的发展需求的下一代网络取证系统模型。

  6. The Territory, a Container of Local Specificities: Evidence by Analysis of the Local Productive System of Ksar-Hellal

    Directory of Open Access Journals (Sweden)

    MAKRAM GAALICHE

    2013-01-01

    Full Text Available This article aims to highlight the relevance of the territory in the experience of local development. Indeed, by an application on a Tunisian case, it was shown that the territory of Ksar-Hellal is implicated in the functioning of its local production system, specializing in textile and clothing. It turned out that the Hilalian territory is abundant in specific economic resources such as competition, complementarity, and non-economic such as cooperation, technological externalities and social values. Those resources that are specific to the Hilalian territory are essential to stimulate the local dynamics of the productive system in question.

  7. Interpreting Evidence.

    Science.gov (United States)

    Munsart, Craig A.

    1993-01-01

    Presents an activity that allows students to experience the type of discovery process that paleontologists necessarily followed during the early dinosaur explorations. Students are read parts of a story taken from the "American Journal of Science" and interpret the evidence leading to the discovery of Triceratops and Stegosaurus. (PR)

  8. GSTT1 Null Genotype Significantly Increases the Susceptibility to Urinary System Cancer: Evidences from 63,876 Subjects.

    Science.gov (United States)

    Wang, Ying; He, Jing; Ma, Tian-Jiao; Lei, Wei; Li, Feng; Shen, Han; Shen, Zhen-Ya

    2016-01-01

    GSTT1 gene plays an important role in detoxification and clearance of reactive oxygen species(ROS). A null variant in this gene has been demonstrated to confer cancer susceptibility. Although many studies have demonstrated the association between GSTT1 null polymorphism and urinary system cancer susceptibility, several publications reported opposite conclusions. For better understanding the effects of this polymorphism on the risk of urinary system cancer, a updated meta-analysis was performed with a total of 26,666 cases and 37,210 controls extracted from 117 studies, by following the latest meta-analysis guidelines (PRISMA). The results suggested that the GSTT1 null genotype was significantly associated with an increased risk of urinary system cancer (OR=1.13, 95%CI=1.05-1.22). Furthermore, stratified analyses by the type of cancer, ethnicity, source of control and quality score presented a significantly increased risk associated with GSTT1 null genotype in bladder and prostate cancer subgroup, Caucasians and Indians subgroup, population-based(PB) subgroup, medium quality and low quality subgroup. Overall, our meta-analysis suggested that GSTT1 null genotype is a potential cancer susceptibility variant. Well-designed and large-cohort studies are needed to confirm the association between GSTT1 null genotype and urinary system cancer risk.

  9. The role of domain-general frontal systems in language comprehension: evidence from dual-task interference and semantic ambiguity.

    Science.gov (United States)

    Rodd, Jennifer M; Johnsrude, Ingrid S; Davis, Matthew H

    2010-12-01

    Neuroimaging studies have shown that the left inferior frontal gyrus (LIFG) plays a critical role in semantic and syntactic aspects of speech comprehension. It appears to be recruited when listeners are required to select the appropriate meaning or syntactic role for words within a sentence. However, this region is also recruited during tasks not involving sentence materials, suggesting that the systems involved in processing ambiguous words within sentences are also recruited for more domain-general tasks that involve the selection of task-relevant information. We use a novel dual-task methodology to assess whether the cognitive system(s) that are engaged in selecting word meanings are also involved in non-sentential tasks. In Experiment 1, listeners were slower to decide whether a visually presented letter is in upper or lower case when the sentence that they are simultaneously listening to contains words with multiple meanings (homophones), compared to closely matched sentences without homophones. Experiment 2 indicates that this interference effect is not tied to the occurrence of the homophone itself, but rather occurs when listeners must reinterpret a sentence that was initially misparsed. These results suggest some overlap between the cognitive system involved in semantic disambiguation and the domain-general process of response selection required for the case-judgement task. This cognitive overlap may reflect neural overlap in the networks supporting these processes, and is consistent with the proposal that domain-general selection processes in inferior frontal regions are critical for language comprehension.

  10. Effect of industrially produced trans fat on markers of systemic inflammation: evidence from a randomized trial in women

    DEFF Research Database (Denmark)

    Bendsen, Nathalie T.; Stender, Steen; Szecsi, Pal B.;

    2011-01-01

    Consumption of industrially produced trans fatty acids (IP-TFA) has been positively associated with systemic markers of low-grade inflammation and endothelial dysfunction in cross-sectional studies, but results from intervention studies are inconclusive. Therefore, we conducted a 16 week double...

  11. Case Study of Ecstatic Meditation: fMRI and EEG Evidence of Self-Stimulating a Reward System

    Directory of Open Access Journals (Sweden)

    Michael R. Hagerty

    2013-01-01

    Full Text Available We report the first neural recording during ecstatic meditations called jhanas and test whether a brain reward system plays a role in the joy reported. Jhanas are Altered States of Consciousness (ASC that imply major brain changes based on subjective reports: (1 external awareness dims, (2 internal verbalizations fade, (3 the sense of personal boundaries is altered, (4 attention is highly focused on the object of meditation, and (5 joy increases to high levels. The fMRI and EEG results from an experienced meditator show changes in brain activity in 11 regions shown to be associated with the subjective reports, and these changes occur promptly after jhana is entered. In particular, the extreme joy is associated not only with activation of cortical processes but also with activation of the nucleus accumbens (NAc in the dopamine/opioid reward system. We test three mechanisms by which the subject might stimulate his own reward system by external means and reject all three. Taken together, these results demonstrate an apparently novel method of self-stimulating a brain reward system using only internal mental processes in a highly trained subject.

  12. Biochemical evidence for the presence of two α-glucoside ABC-transport systems in the hyperthermophilic archaeon Pyrococcus furiosus

    NARCIS (Netherlands)

    Koning, Sonja M.; Konings, Wil N.; Driessen, Arnold J.M.

    2002-01-01

    The hyperthermophilic archaeon Pyrococcus furiosus can utilize different carbohydrates, such as starch, maltose and trehalose. Uptake of α-glucosides is mediated by two different, binding protein-dependent, ATP-binding cassette (ABC)-type transport systems. The maltose transporter also transports tr

  13. Addressing the Needs of Youth with Disabilities in the Juvenile Justice System: The Current Status of Evidence-Based Research.

    Science.gov (United States)

    Mears, Daniel P.; Aron, Laudan; Bernstein, Jenny

    This report summarizes the state of knowledge about children and youth with disabilities at risk of delinquency or already involved with the juvenile justice system. It reviews the existing research as well as perspectives of service providers, administrators, policy makers, and advocates. Following an executive summary and introductory chapter,…

  14. GSTT1 Null Genotype Significantly Increases the Susceptibility to Urinary System Cancer: Evidences from 63,876 Subjects

    Science.gov (United States)

    Wang, Ying; He, Jing; Ma, Tian-Jiao; Lei, Wei; Li, Feng; Shen, Han; Shen, Zhen-Ya

    2016-01-01

    GSTT1 gene plays an important role in detoxification and clearance of reactive oxygen species(ROS). A null variant in this gene has been demonstrated to confer cancer susceptibility. Although many studies have demonstrated the association between GSTT1 null polymorphism and urinary system cancer susceptibility, several publications reported opposite conclusions. For better understanding the effects of this polymorphism on the risk of urinary system cancer, a updated meta-analysis was performed with a total of 26,666 cases and 37,210 controls extracted from 117 studies, by following the latest meta-analysis guidelines (PRISMA). The results suggested that the GSTT1 null genotype was significantly associated with an increased risk of urinary system cancer (OR=1.13, 95%CI=1.05-1.22). Furthermore, stratified analyses by the type of cancer, ethnicity, source of control and quality score presented a significantly increased risk associated with GSTT1 null genotype in bladder and prostate cancer subgroup, Caucasians and Indians subgroup, population-based(PB) subgroup, medium quality and low quality subgroup. Overall, our meta-analysis suggested that GSTT1 null genotype is a potential cancer susceptibility variant. Well-designed and large-cohort studies are needed to confirm the association between GSTT1 null genotype and urinary system cancer risk.

  15. A Ubiquitous English Vocabulary Learning System: Evidence of Active/Passive Attitudes vs. Usefulness/Ease-of-Use

    Science.gov (United States)

    Huang, Yueh-Min; Huang, Yong-Ming; Huang, Shu-Hsien; Lin, Yen-Ting

    2012-01-01

    English vocabulary learning and ubiquitous learning have separately received considerable attention in recent years. However, research on English vocabulary learning in ubiquitous learning contexts has been less studied. In this study, we develop a ubiquitous English vocabulary learning (UEVL) system to assist students in experiencing a systematic…

  16. Repetition Priming Influences Distinct Brain Systems: Evidence From Task-Evoked Data and Resting-State Correlations

    Science.gov (United States)

    Wig, Gagan S.; Buckner, Randy L.; Schacter, Daniel L.

    2009-01-01

    Behavioral dissociations suggest that a single experience can separately influence multiple processing components. Here we used a repetition priming functional magnetic resonance imaging paradigm that directly contrasted the effects of stimulus and decision changes to identify the underlying brain systems. Direct repetition of stimulus features caused marked reductions in posterior regions of the inferior temporal lobe that were insensitive to whether the decision was held constant or changed between study and test. By contrast, prefrontal cortex showed repetition effects that were sensitive to the exact stimulus-to-decision mapping. Analysis of resting-state functional connectivity revealed that the dissociated repetition effects are embedded within distinct brain systems. Regions that were sensitive to changes in the stimulus correlated with perceptual cortices, whereas the decision changes attenuated activity in regions correlated with middle-temporal regions and a frontoparietal control system. These results thus explain the long-known dissociation between perceptual and conceptual components of priming by revealing how a single experience can separately influence distinct, concurrently active brain systems. PMID:19225167

  17. A Prospective Examination of Clinician and Supervisor Turnover Within the Context of Implementation of Evidence-Based Practices in a Publicly-Funded Mental Health System.

    Science.gov (United States)

    Beidas, Rinad S; Marcus, Steven; Wolk, Courtney Benjamin; Powell, Byron; Aarons, Gregory A; Evans, Arthur C; Hurford, Matthew O; Hadley, Trevor; Adams, Danielle R; Walsh, Lucia M; Babbar, Shaili; Barg, Frances; Mandell, David S

    2016-09-01

    Staff turnover rates in publicly-funded mental health settings are high. We investigated staff and organizational predictors of turnover in a sample of individuals working in an urban public mental health system that has engaged in a system-level effort to implement evidence-based practices. Additionally, we interviewed staff to understand reasons for turnover. Greater staff burnout predicted increased turnover, more openness toward new practices predicted retention, and more professional recognition predicted increased turnover. Staff reported leaving their organizations because of personal, organizational, and financial reasons; just over half of staff that left their organization stayed in the public mental health sector. Implications include an imperative to focus on turnover, with a particular emphasis on ameliorating staff burnout.

  18. [Enterovirus nosocomial infections in a neonatal care unit: from diagnosis to evidence, from a clinical observation of a central nervous system infection].

    Science.gov (United States)

    Farcy, C; Mirand, A; Marque Juillet, S; Henquell, C; Neulier, C; Foucaud, P; Peigue-Lafeuille, H

    2012-09-01

    Although enteroviruses generally cause asymptomatic or mild disease, neonates are at higher risk for severe illnesses, among which systemic disease characterized by multiorgan involvement is a potentially fatal condition. Enterovirus neonatal infections may be the source of nosocomial infections in neonatology or in pediatric intensive care units. We report central nervous system infections due to Echovirus 11 in two neonates and the molecular evidence of nosocomial transmission of this strain in a neonatal unit by enterovirus genotyping and phylogenetic analysis. This report illustrates the importance of including enterovirus genome detection in the sepsis screening concomitantly with bacteriological investigations performed at admission of a neonate. Rapid diagnosis and subsequent genotyping could have a beneficial impact on clinical practices at the individual level (reducing the length of antibiotic therapy) and public health policy at the collective level by reinforcing hygiene measures to prevent nosocomial infections, with nurseries and neonatal units being at greater risks.

  19. Using Community Partnerships to Better Understand the Barriers to Using an Evidence-Based, Parent-Mediated Intervention for Autism Spectrum Disorder in a Medicaid System.

    Science.gov (United States)

    Pickard, Katherine E; Kilgore, Amanda N; Ingersoll, Brooke R

    2016-06-01

    Service use disparities have been noted to impede under-resourced families' ability to access high-quality services for their child with autism spectrum disorder (ASD). These disparities are particularly relevant for parent-mediated interventions and may suggest a lack of fit between these interventions and the needs of under-resourced community settings. This study used Roger's Diffusion of Innovations theory to guide community partnerships aimed at understanding the perceived compatibility, complexity, and relative advantage of using an evidence-based, parent-mediated intervention (Project ImPACT) within a Medicaid system. Three focus groups were conducted with 16 Medicaid-eligible parents, and three focus groups were conducted with 16 ASD providers operating within a Medicaid system. Across all groups, parents and providers reported general interest in using Project ImPACT. However, primary themes emerged regarding the need to (a) reduce the complexity of written materials; (b) allow for a more flexible program delivery; (c) ensure a strong parent-therapist alliance; (d) involve the extended family; and (e) help families practice the intervention within their preexisting routines. Results are discussed as they relate to the design and fit of evidence-based, parent-mediated interventions for under-resourced community settings.

  20. The role of information systems in non-routine transit use of university students: Evidence from Brazil and Denmark

    DEFF Research Database (Denmark)

    Kaplan, Sigal; Monteiro, Mayara Moraes; Anderson, Marie Karen

    2017-01-01

    ), characterized by a lower perceived level-of-service and non-integrated information sources. Data from a tailor-made survey of 1123 university students were collected. Structural equation models were employed for explaining the use of transit as a function of the observed respondent characteristics...... availability. The hypothesized relations are anchored theoretically in the Technology Acceptance Model and validated empirically in two case-studies: (i) Copenhagen (Denmark), characterized by a highly integrated transit system with an advanced web-based information system; (ii) Recife and Natal (Brazil...... and the latent constructs. The results show that: (i) information search quality and source explain transit use; (ii) information quality underlies level-of-service and familiarity; (iii) the use of real-time information links to information quality and familiarity; (iv) general transit use and non-routine use...

  1. Evidence of a Vocalic Proto-System in the Baboon (Papio papio) Suggests Pre-Hominin Speech Precursors

    Science.gov (United States)

    Boë, Louis-Jean; Berthommier, Frédéric; Legou, Thierry; Captier, Guillaume; Kemp, Caralyn; Sawallis, Thomas R.; Becker, Yannick; Rey, Arnaud; Fagot, Joël

    2017-01-01

    Language is a distinguishing characteristic of our species, and the course of its evolution is one of the hardest problems in science. It has long been generally considered that human speech requires a low larynx, and that the high larynx of nonhuman primates should preclude their producing the vowel systems universally found in human language. Examining the vocalizations through acoustic analyses, tongue anatomy, and modeling of acoustic potential, we found that baboons (Papio papio) produce sounds sharing the F1/F2 formant structure of the human [ɨ æ ɑ ɔ u] vowels, and that similarly with humans those vocalic qualities are organized as a system on two acoustic-anatomic axes. This confirms that hominoids can produce contrasting vowel qualities despite a high larynx. It suggests that spoken languages evolved from ancient articulatory skills already present in our last common ancestor with Cercopithecoidea, about 25 MYA. PMID:28076426

  2. Dermal inorganic gadolinium concentrations: evidence for in vivo transmetallation and long-term persistence in nephrogenic systemic fibrosis

    DEFF Research Database (Denmark)

    Abraham, J L; Thakral, C; Skov, L;

    2008-01-01

    BACKGROUND: Gadolinium (Gd)-based magnetic resonance contrast agents (GBMCA), including gadodiamide, have been identified as the probable causative agents of the serious disease, nephrogenic systemic fibrosis (NSF). OBJECTIVES: To investigate retained Gd-containing deposits in skin biopsies from ......+ from gadodiamide, and its retention in apatite-like deposits. We suggest that Gd may be mobilized over time from bone stores, explaining variably delayed onset of NSF and increasing skin concentration over time in patients with NSF....

  3. Dermal inorganic gadolinium concentrations: evidence for in vivo transmetallation and long-term persistence in nephrogenic systemic fibrosis

    DEFF Research Database (Denmark)

    Abraham, J.L.; Thakral, C.; Skov, L.;

    2008-01-01

    Background Gadolinium (Gd)-based magnetic resonance contrast agents (GBMCA), including gadodiamide, have been identified as the probable causative agents of the serious disease, nephrogenic systemic fibrosis (NSF). Objectives To investigate retained Gd-containing deposits in skin biopsies from pa...... gadodiamide, and its retention in apatite-like deposits. We suggest that Gd may be mobilized over time from bone stores, explaining variably delayed onset of NSF and increasing skin concentration over time in patients with NSF Udgivelsesdato: 2008/2...

  4. Links between community violence and the family system: evidence from children's feelings of relatedness and perceptions of parent behavior.

    Science.gov (United States)

    Lynch, Michael; Cicchetti, Dante

    2002-01-01

    In this study, we examined some of the ways in which broader ecological systems may influence the organization of behavior within the family system. Specifically, links between exposure to community violence and children's relationships with maternal caregivers were investigated in a sample of 127 urban children between the ages of 7 and 13 years. Children were asked to indicate whether they had been exposed to a wide variety of violent events. In addition, their feelings of relatedness and separation anxiety, and their perceptions of maternal behavior were assessed. It was expected that exposure to community violence would be associated with feeling less secure with caregivers. Consistent with predictions from ecological-transactional theory, data supported this hypothesis. Children who reported that they had been exposed to high levels of community violence also indicated that they felt less positive affect when with their caregiver, were dissatisfied with how close they felt to her, felt more separation anxiety, and reported more negative maternal behavior than children exposed to less violence. Findings are discussed in terms of how violence may affect the family system and the protective function of human attachment.

  5. Different temporal structure for form versus surface cortical color systems--evidence from chromatic non-linear VEP.

    Directory of Open Access Journals (Sweden)

    David P Crewther

    Full Text Available Physiological studies of color processing have typically measured responses to spatially varying chromatic stimuli such as gratings, while psychophysical studies of color include color naming, color and light, as well as spatial and temporal chromatic sensitivities. This raises the question of whether we have one or several cortical color processing systems. Here we show from non-linear analysis of human visual evoked potentials (VEP the presence of distinct and independent temporal signatures for form and surface color processing. Surface color stimuli produced most power in the second order Wiener kernel, indicative of a slowly recovering neural system, while chromatic form stimulation produced most power in the first order kernel (showing rapid recovery. We find end-spectral saturation-dependent signals, easily separable from achromatic signals for surface color stimuli. However physiological responses to form color stimuli, though varying somewhat with saturation, showed similar waveform components. Lastly, the spectral dependence of surface and form color VEP was different, with the surface color responses almost vanishing with yellow-grey isoluminant stimulation whereas the form color VEP shows robust recordable signals across all hues. Thus, surface and form colored stimuli engage different neural systems within cortex, pointing to the need to establish their relative contributions under the diverse chromatic stimulus conditions used in the literature.

  6. Different temporal structure for form versus surface cortical color systems--evidence from chromatic non-linear VEP.

    Science.gov (United States)

    Crewther, David P; Crewther, Sheila G

    2010-12-20

    Physiological studies of color processing have typically measured responses to spatially varying chromatic stimuli such as gratings, while psychophysical studies of color include color naming, color and light, as well as spatial and temporal chromatic sensitivities. This raises the question of whether we have one or several cortical color processing systems. Here we show from non-linear analysis of human visual evoked potentials (VEP) the presence of distinct and independent temporal signatures for form and surface color processing. Surface color stimuli produced most power in the second order Wiener kernel, indicative of a slowly recovering neural system, while chromatic form stimulation produced most power in the first order kernel (showing rapid recovery). We find end-spectral saturation-dependent signals, easily separable from achromatic signals for surface color stimuli. However physiological responses to form color stimuli, though varying somewhat with saturation, showed similar waveform components. Lastly, the spectral dependence of surface and form color VEP was different, with the surface color responses almost vanishing with yellow-grey isoluminant stimulation whereas the form color VEP shows robust recordable signals across all hues. Thus, surface and form colored stimuli engage different neural systems within cortex, pointing to the need to establish their relative contributions under the diverse chromatic stimulus conditions used in the literature.

  7. An evidence-based toolkit for the development of effective and sustainable root cause analysis system safety solutions.

    Science.gov (United States)

    Hettinger, A Zachary; Fairbanks, Rollin J; Hegde, Sudeep; Rackoff, Alexandra S; Wreathall, John; Lewis, Vicki L; Bisantz, Ann M; Wears, Robert L

    2013-01-01

    Root cause analysis (RCA) after adverse events in healthcare is a standard practice at many institutions. However, healthcare has failed to see a dramatic improvement in patient safety over the last decade. In order to improve the RCA process, this study used systems safety science, which is based partly on human factors engineering principles and has been applied with success in other high-risk industries like aviation. A multi-institutional dataset of 334 RCA cases and 782 solutions was analyzed using qualitative methods. A team of safety science experts developed a model of 13 RCA solutions categories through an iterative process, using semi-structured interview data from 44 frontline staff members from 7 different hospital-based unit types. These categories were placed in a model and toolkit to help guide RCA teams in developing sustainable and effective solutions to prevent future adverse events. This study was limited by its retrospective review of cases and use of interviews rather than clinical observations. In conclusion, systems safety principles were used to develop guidelines for RCA teams to promote systems-level sustainable and effective solutions for adverse events.

  8. Signed language and human action processing: evidence for functional constraints on the human mirror-neuron system.

    Science.gov (United States)

    Corina, David P; Knapp, Heather Patterson

    2008-12-01

    In the quest to further understand the neural underpinning of human communication, researchers have turned to studies of naturally occurring signed languages used in Deaf communities. The comparison of the commonalities and differences between spoken and signed languages provides an opportunity to determine core neural systems responsible for linguistic communication independent of the modality in which a language is expressed. The present article examines such studies, and in addition asks what we can learn about human languages by contrasting formal visual-gestural linguistic systems (signed languages) with more general human action perception. To understand visual language perception, it is important to distinguish the demands of general human motion processing from the highly task-dependent demands associated with extracting linguistic meaning from arbitrary, conventionalized gestures. This endeavor is particularly important because theorists have suggested close homologies between perception and production of actions and functions of human language and social communication. We review recent behavioral, functional imaging, and neuropsychological studies that explore dissociations between the processing of human actions and signed languages. These data suggest incomplete overlap between the mirror-neuron systems proposed to mediate human action and language.

  9. Soil nitrogen drives community-level phosphorus resorption in a co-limited system: evidence from a northern hardwood forest

    Science.gov (United States)

    See, C. R.; Yanai, R. D.

    2013-12-01

    Fertilization studies in northeastern forests suggest that forest productivity may be co-limited by nitrogen and phosphorus. Foliar nutrient resorption is a crucial conservation mechanism for plants. Resorption controls litterfall nutrient concentration, and litterfall is the largest aboveground nutrient flux in this system. Previous studies have attempted to link the foliar resorption of P to soil P status with mixed results. We propose that in an N and P co-limited system, foliar resorption of P may be linked to N availability. Here we compare the foliar chemistry of six hardwood tree species to soil chemistry across 18 plots in 6 stands in Bartlett Experimental Forest, New Hampshire. Resorption efficiency was calculated by species as the percent difference between green and senesced leaves. We weighted the resorption efficiencies for dominant tree species in each plot by their litterfall mass to create a community-level estimate of resorption for each plot. Estimates of soil N content to 30 centimeters in the mineral soil were strongly correlated with community-level estimates of both P resorption efficiency (p=0.002) and proficiency (p=0.006). At the population level, this trend was observed in four of the six tree species sampled. Neither N nor P resorption was correlated with any of the soil P fractions we examined. If N availability drives biological P conservation, it would provide an important mechanism for the coupled cycling of N and P in co-limited systems.

  10. The long-wavelength thermal emission of the Pluto-Charon system from Herschel observations. Evidence for emissivity effects

    CERN Document Server

    Lellouch, E; Fornasier, S; Lim, T; Stansberry, J; Vilenius, E; Kiss, Cs; Müller, T; Marton, G; Protopapa, S; Panuzzo, P; Moreno, R

    2016-01-01

    Thermal observations of the Pluto-Charon system acquired by the Herschel Space Observatory in February 2012 are presented. They consist of photometric measurements with the PACS and SPIRE instruments (nine visits to the Pluto system each), covering six wavelengths from 70 to 500 $\\mu$m altogether. The thermal light curve of Pluto-Charon is observed in all filters, albeit more marginally at 160 and especially 500 $\\mu$m. Putting these data into the context of older ISO, Spitzer and ground-based observations indicates that the brightness temperature (T$_B$) of the system (rescaled to a common heliocentric distance) drastically decreases with increasing wavelength, from $\\sim$53 K at 20 $\\mu$m to $\\sim$35 K at 500 $\\mu$m, and perhaps ever less at longer wavelengths. Considering a variety of diurnal and/or seasonal thermophysical models, we show that T$_B$ values of 35 K are lower than any expected temperature for the dayside surface or subsurface of Pluto and Charon, implying a low surface emissivity. Based on m...

  11. Mu-wave activity in schizophrenia: Evidence of a dysfunctional mirror neuron system from an Indian study

    Directory of Open Access Journals (Sweden)

    Sayantanava Mitra

    2014-01-01

    Full Text Available Background: The ′mirror-neuron system′ is thought to play an important role in automatic decoding of biological motions and interpretation of socially adaptive environmental stimuli. Accordingly, a dysfunction in this system in schizophrenia has been hypothesised to mediate the psychotic manifestations. Materials and Methods: As a part of an ongoing study, we evaluated the mirror neuron system using ′EEG mu-wave (8-13 Hz suppression′ paradigm in 15 drug naïve/drug free patients and compared the working to 15 age, sex and education matched controls. We also correlated the psychopathology scores on PANSS with the mu wave suppression in the schizophrenia patients, at baseline. We used high (192-channel resolution EEG to record the mu rhythm while the subjects watched alternating sequences of a socially-relevant biological motion and white visual-noise on a custom made video-clip. Results: We found a significant difference in the degree of mu wave suppression between the two groups. We also found that the degree of mu suppression over right sensorimotor cortex at presentation correlated significantly and negatively with thought disorder in the patient group, and had a strong linear relationship. Conclusion: This study replicates past findings regarding a dysfunctional mirror neuron system in schizophrenia patients, and also emphasizes the role of rMNS in schizophrenic thought disorders.

  12. From Augustine of Hippo's Memory Systems to Our Modern Taxonomy in Cognitive Psychology and Neuroscience of Memory: A 16-Century Nap of Intuition before Light of Evidence.

    Science.gov (United States)

    Cassel, Jean-Christophe; Cassel, Daniel; Manning, Lilianne

    2013-03-01

    Over the last half century, neuropsychologists, cognitive psychologists and cognitive neuroscientists interested in human memory have accumulated evidence showing that there is not one general memory function but a variety of memory systems deserving distinct (but for an organism, complementary) functional entities. The first attempts to organize memory systems within a taxonomic construct are often traced back to the French philosopher Maine de Biran (1766-1824), who, in his book first published in 1803, distinguished mechanical memory, sensitive memory and representative memory, without, however, providing any experimental evidence in support of his view. It turns out, however, that what might be regarded as the first elaborated taxonomic proposal is 14 centuries older and is due to Augustine of Hippo (354-430), also named St Augustine, who, in Book 10 of his Confessions, by means of an introspective process that did not aim at organizing memory systems, nevertheless distinguished and commented on sensible memory, intellectual memory, memory of memories, memory of feelings and passion, and memory of forgetting. These memories were envisaged as different and complementary instances. In the current study, after a short biographical synopsis of St Augustine, we provide an outline of the philosopher's contribution, both in terms of questions and answers, and focus on how this contribution almost perfectly fits with several viewpoints of modern psychology and neuroscience of memory about human memory functions, including the notion that episodic autobiographical memory stores events of our personal history in their what, where and when dimensions, and from there enables our mental time travel. It is not at all meant that St Augustine's elaboration was the basis for the modern taxonomy, but just that the similarity is striking, and that the architecture of our current viewpoints about memory systems might have preexisted as an outstanding intuition in the philosopher

  13. Evidence of El Niño driven desiccation cycles in a shallow estuarine lake: The evolution and fate of Africa's largest estuarine system, Lake St Lucia

    Science.gov (United States)

    Humphries, M. S.; Green, A. N.; Finch, J. M.

    2016-12-01

    Projections of an increase in drought frequency and intensity over the next century are expected to have severe implications for a number of globally important coastal ecosystems. In this paper, we present geochemical data from three sediment cores extracted from the main depositional basins of Lake St Lucia, Africa's largest estuarine system. Lake St Lucia is subject to extreme natural variations in salinity. The sedimentary record documents the evolution of the system from a relatively deep-water, open lagoon to a confined, shallow estuarine lake that today is highly sensitive to changes in freshwater supply. This is particularly evident in the northern portions of the system, where the presence of distinct halite-enriched horizons document episodes of prolonged drought. The lateral persistence of these halite layers, as revealed by seismic profiling, point to a system-wide onset of desiccation associated with a major shift in the regional hydroclimate. The most severe drought events identified, which may have lasted several years, occur at 1100 and 1750 cal year BP, and are associated with known peaks in El Niño frequency and intensity. Our analyses suggest that past cycles of desiccation and hyper-salinity have been controlled by climatic changes related to ENSO intensification. This study provides a valuable new record from a key ENSO-sensitive region of the Southern Hemisphere. Our findings have important relevance for understanding ENSO variability across the Indo-Pacific region and the influence exerted on systems sensitive to changes in moisture balance.

  14. Evidências de validade do bender: sistema de pontuação gradual (B-SPG Evidences of validity of bender: gradual scoring system (B-SPG

    Directory of Open Access Journals (Sweden)

    Ana Paula Porto Noronha

    2007-01-01

    Full Text Available Esse estudo objetivou buscar evidências de validade para o teste de Bender - Sistema de Pontuação Gradual (B-SPG, por meio da investigação das mudanças desenvolvimentais, expressas pela relação entre os escores com a idade. Fizeram parte do estudo 1052 crianças de oito escolas públicas estaduais e municipais de Campinas e região, de pré-escola à 4ª série do ensino fundamental. As idades variaram entre 6 e 10 anos, com uma média de 8,35 anos. Os achados revelaram que conforme aumentou a idade, diminuiu a pontuação obtida pelo B-SPG, indicando que com o aumento da idade, as distorções da cópia progressivamente diminuem. Embora outros estudos sejam recomendados, os resultados aqui apresentados estão em consonância com trabalhos que buscaram a constatação de que é possível encontrar um caráter maturacional nas figuras do teste.This study aimed to gather evidences of validity for the Bender test - Gradual Scoring System (B-SPG, investigating developmental changes based on the relationships between its scores and the ages of the children. The study investigated 1052 children attending from pre-school to fourth grade of eight municipal and state public schools of Campinas (a city in the state of São Paulo, Brazil and the surrounding region. Ages ranged from six to ten years old, with an average of 8,35. The findings indicated that according to the increase of age, the B-SPG scores diminished, suggesting that the distortions progressively diminish as the children become older. Although other studies are suggested, the results presented here are consonant with researches that sought to establish that it is possible too find a maturational character among the figures of the test.

  15. History of Plant Phenological Observation in Hungary and Plans for Renewal of System to detect Evidence of the Climate Change

    Science.gov (United States)

    Hunkar, M.; Dunkel, Z.

    2009-04-01

    The first plant protection warning was issued 1760 by the Senate of the Town of Debrecen concerning the destruction of caterpillar's nest. In the middle of the 19th century the first responsible Hungarian Government issued a note in which the minister takes measurements for the phytosanitary safety of agricultural products. Though Hungary had not got independent institutional system for plant protection at the end of the 19th c., still in the middle of the 1870s, the territory of the country was protected with harmonised quarantine measures from the introduction of Colorado beetle. A new era started both in Europe and in Hungary with the devastation caused by Phylloxera vastatrix in vineyards. In 1876, the Act 29 definitely specified the measures to be taken for preventing the spread of the pest and the damages caused by it; and it was proclaimed in both Chambers of the Parliament. This incident resulted basically in the launching for the establishment of an independent plant protection institution. In l880, the National Committee on Phylloxera, then in 1881, the National Experimental Station for Phylloxera was set up, this latter considered as the first nucleus of the Hungarian plant protection organisation. The international plant protection convention, concluded in 1929 and signed by our country, had a great role in the history of the development of the plant protection organisation. Hungary agreed to establish an official plant protection organization which should consist of a plant protection service and a research institute. In compliance with the Ministerial Decree 49.000/1932 the Hungarian Plant Protection Service was set up which can now be taken for the first organisation of the uniform national plant protection administration system. Plant protection stations were established in 1954. The plant phenological observation network was run by the plant protection administration but financially was maintained by OMSZ therefore the main aim of the phenological

  16. Adult non-communicable disease mortality in Africa and Asia: evidence from INDEPTH Health and Demographic Surveillance System sites

    Directory of Open Access Journals (Sweden)

    P. Kim Streatfield

    2014-10-01

    Full Text Available Background: Mortality from non-communicable diseases (NCDs is a major global issue, as other categories of mortality have diminished and life expectancy has increased. The World Health Organization's Member States have called for a 25% reduction in premature NCD mortality by 2025, which can only be achieved by substantial reductions in risk factors and improvements in the management of chronic conditions. A high burden of NCD mortality among much older people, who have survived other hazards, is inevitable. The INDEPTH Network collects detailed individual data within defined Health and Demographic Surveillance sites. By registering deaths and carrying out verbal autopsies to determine cause of death across many such sites, using standardised methods, the Network seeks to generate population-based mortality statistics that are not otherwise available. Objective: To describe patterns of adult NCD mortality from INDEPTH Network sites across Africa and Asia, according to the WHO 2012 verbal autopsy (VA cause categories, with separate consideration of premature (15–64 years and older (65+ years NCD mortality. Design: All adult deaths at INDEPTH sites are routinely registered and followed up with VA interviews. For this study, VA archives were transformed into the WHO 2012 VA standard format and processed using the InterVA-4 model to assign cause of death. Routine surveillance data also provide person-time denominators for mortality rates. Results: A total of 80,726 adult (over 15 years deaths were documented over 7,423,497 person-years of observation. NCDs were attributed as the cause for 35.6% of these deaths. Slightly less than half of adult NCD deaths occurred in the 15–64 age group. Detailed results are presented by age and sex for leading causes of NCD mortality. Per-site rates of NCD mortality were significantly correlated with rates of HIV/AIDS-related mortality. Conclusions: These findings present important evidence on the distribution of

  17. Evidence Standards and Litigation

    DEFF Research Database (Denmark)

    Guerra, Alice; Luppi, Barbara; Parisi, Francesco

    of the case. We study how these factors jointly affect the parties’ litigation expenditures and the selection of cases brought to the courts. The evidence standard has different effects on different types of cases, reducing litigation for high-merit cases when standards are set low and increasing litigation......In litigation models, the parties’ probability to succeed in a lawsuit hinge upon two main factors: the merits of the parties’ claims and their litigation efforts (Katz, 1988; Hirshleifer, 1989; Farmer and Pecorino, 1999). In this paper we extend this framework to consider an important procedural...... aspect of the legal system: the evidence standard. We recast the conventional rent-seeking model to consider how alternative evidence standards affect litigation choices. We analyze the interrelation between different evidence standards, the effectiveness of the parties’ efforts, and the merits...

  18. Astronomical Oxygen Isotopic Evidence for Supernova Enrichment of the Solar System Birth Environment by Propagating Star Formation

    CERN Document Server

    Young, Edward D; Smith, Rachel L; Morris, Mark R; Pontoppidan, Klaus M

    2010-01-01

    New infrared absorption measurements of oxygen isotope ratios in CO gas from individual young stellar objects confirm that the solar system is anomalously high in its 18O/17O ratio compared with extra-solar oxygen in the Galaxy. We show that this difference in oxygen isotope ratios is best explained by 1 per cent enrichment of the proto-solar molecular cloud by ejecta from type II supernovae from a cluster having of order a few hundred stars that predated the Sun by at least 10 to 20 Myr. The likely source of exogenous oxygen was the explosion of one or more B stars during a process of propagating star formation.

  19. The Transiting System GJ1214: High-Precision Defocused Transit Observations and a Search for Evidence of Transit Timing Variation

    DEFF Research Database (Denmark)

    Harpsøe, Kennet Bomann West; Hardis, S.; Hinse, T. C.;

    2012-01-01

    Aims: We present 11 high-precision photometric transit observations of the transiting super-Earth planet GJ1214b. Combining these data with observations from other authors, we investigate the ephemeris for possible signs of transit timing variations (TTVs) using a Bayesian approach. Methods......: The observations are used to determine the photometric parameters and the physical properties of the GJ1214 system. Our results are in good agreement with published values. Individual times of mid-transit are measured with uncertainties as low as 10s, allowing us to reduce the uncertainty in the orbital period...

  20. The Iceland Deep Drilling Project: (III) Evidence for amphibolite grade contact metamorphism in an active geothermal system

    Science.gov (United States)

    Marks, N.; Schiffman, P.; Zierenberg, R. A.; Franzson, H.

    2008-12-01

    One of the scientific goals of the Iceland Deep Drilling Project is to reach the depths of transition from greenschist to amphibolite grade metamorphism in an active geothermal system. The deepest borehole to date in the Reykjanes system is RN-17, which was drilled to a depth of 3082 m. This well had been considered as a candidate for deepening by the IDDP until it collapsed during a flow test in November 2005. Temperatures in the lower portion of the borehole were never recorded due to an obstruction at 2100 m depth, but are estimated to be approximately 340°C. Epidote, albite, and actinolite are ubiquitous within pillow basalt, hyaloclastite, and in veins, implying that greenschist grade conditions have been attained throughout much of the well below approximately 1200 m. Intrusive lithologies constitute approximately 50% of the observed cuttings between 2600 and 2700 m. These intrusive rocks have produced small, but recognizable contact metamorphic effects characterized by granoblastic hornfels consisting of amphibolite grade assemblages of quartz + anorthite + diopside + magnetite + titanite. These have, in turn, been locally cut by actinolite veins, presumably reflective of the present-day, thermal state of the hydrothermal system at these depths. Based on their siliceous bulk composition, we believe the hornfels represent the thermally- recrystallized products of earlier-formed, hydrothermal veins consisting of quartz, epidote, and actinolite. The metamorphic plagioclase is distinctly more anorthitic (An90 to An98) than igneous plagioclase in adjacent mafic intrusives (An33 to An80) and also exhibits consistently lower Mg content and higher iron (up to 2.07 wt.% as Fe2O3). Stoichiometry implies that much of the iron in hydrothermal anorthite is Fe3+, which may imply recrystallization from precursor epidote under relatively oxidizing conditions. Diopside compositions (average Wo0.48En0.27Fs0.25) are consistently less calcic than hydrothermal clinopyroxenes

  1. Morphostructural investigation of the female reproductive system and molecular evidence for Wolbachia in Balclutha brevis Lindberg 1954 (Hemiptera, Cicadellidae).

    Science.gov (United States)

    Pappalardo, A M; D'Urso, V; Viscuso, R; Ferrito, V; Giunta, M C; Cupani, S; Vitale, D G M

    2016-02-01

    Balclutha brevis Lindberg 1954 (Homoptera, Cicadellidae) is an allochthonous species that is rapidly spreading in Sicily and in mainland Europe due to the wide spread of its host plant and therefore could also compete with populations of native species. Considering these ecological implications, based on the lacking ultrastructural data about the reproductive systems of the Auchenorrhyncha and since previous investigations on the male reproductive system of B. brevis have shown some interesting features, we carried out morphostructural investigations on the female reproductive system of this alien leafhopper. Moreover, given the high interest in literature on Wolbachia entomoparasite and based on our previous studies, we provided a contribution to further investigations in applied sciences. For this aim we performed a molecular analysis on males and females of B. brevis to detect the possible presence of strains of the bacterium known to alter host reproductive biology. The female reproductive system has a morphological organization comparable to the general anatomical features of most of the Auchenorrhyncha species; however, comparing our data with the literature, some considerations are discussed. As for the histological and ultrastructural investigations, our results show a secretory activity of the various examined structures. In the spermatheca of B. brevis, in particular, the secretory activity is more marked in the sac-shaped tract, where histochemical investigations showed a lipid component of the secretion; possible origin of this component is discussed. Moreover, mainly free spermatozoa are found in the sac-shaped tract of the spermatheca and in the common oviduct. As for the latter, an interesting findings is the lack of cuticular intima on the epithelial surface of the common oviduct; furthermore, the observed features and the literature in this regards led us to review the significance of the structure called as spermatheca. The molecular screening

  2. Evidence for existence of quorum sensing in a bioaugmented system by acylated homoserine lactone-dependent quorum quenching.

    Science.gov (United States)

    Zhang, Kun; Zheng, Xin; Shen, Dong-sheng; Wang, Mei-zhen; Feng, Hua-jun; He, Hong-zhen; Wang, Shuo; Wang, Jue-hua

    2015-04-01

    The introduction of a gene, strain, or microbial consortium into an indigenous bacterial population is known as bioaugmentation. This technique has been proposed as an effective strategy for accelerating and enhancing the removal of recalcitrant and toxic compounds during wastewater treatment. In this study, three types of reactors were used to test whether quorum sensing plays an important role in bioaugmented systems. Reverse transcriptase polymerase chain reaction showed that the inoculated strain, HF-1, successfully colonized in the bioaugmented reactor. Meanwhile, no HF-1 colonization was observed in the quorum-quenching and non-bioaugmented reactors. Removal of nicotine in the bioaugmented reactor was almost 100%, and removal of total organic carbon (TOC) was higher than 50%. However, less than 20% of nicotine and 30% of TOC was removed in quorum-quenching and non-bioaugmented reactors. Moreover, the release of acylated homoserine lactones reached the threshold for HF-1 biofilm formation in bioaugmented reactors but not in quorum-quenching or non-bioaugmented reactors. The addition of porcine kidney acylase I, a quenching reagent, to the quorum-quenching reactor hampered the colonization of HF-1. Together, these results demonstrate that quorum sensing plays an important role in HF-1 colonization of bioaugmented systems.

  3. Mesothelioma incidence surveillance systems and claims for workers’ compensation. Epidemiological evidence and prospects for an integrated framework

    Directory of Open Access Journals (Sweden)

    Marinaccio Alessandro

    2012-07-01

    Full Text Available Abstract Background Malignant mesothelioma is an aggressive and lethal tumour strongly associated with exposure to asbestos (mainly occupational. In Italy a large proportion of workers are protected from occupational diseases by public insurance and an epidemiological surveillance system for incident mesothelioma cases. Methods We set up an individual linkage between the Italian national mesothelioma register (ReNaM and the Italian workers’ compensation authority (INAIL archives. Logistic regression models were used to identify and test explanatory variables. Results We extracted 3270 mesothelioma cases with occupational origins from the ReNaM, matching them with 1625 subjects in INAIL (49.7%; 91.2% (1,482 of the claims received compensation. The risk of not seeking compensation is significantly higher for women and the elderly. Claims have increased significantly in recent years and there is a clear geographical gradient (northern and more developed regions having higher claims rates. The highest rates of compensation claims were after work known to involve asbestos. Conclusions Our data illustrate the importance of documentation and dissemination of all asbestos exposure modalities. Strategies focused on structural and systematic interaction between epidemiological surveillance and insurance systems are needed.

  4. Old wine in new bottles: decanting systemic family process research in the era of evidence-based practice.

    Science.gov (United States)

    Rohrbaugh, Michael J

    2014-09-01

    Social cybernetic (systemic) ideas from the early Family Process era, though emanating from qualitative clinical observation, have underappreciated heuristic potential for guiding quantitative empirical research on problem maintenance and change. The old conceptual wines we have attempted to repackage in new, science-friendly bottles include ironic processes (when "solutions" maintain problems), symptom-system fit (when problems stabilize relationships), and communal coping (when we-ness helps people change). Both self-report and observational quantitative methods have been useful in tracking these phenomena, and together the three constructs inform a team-based family consultation approach to working with difficult health and behavior problems. In addition, a large-scale, quantitatively focused effectiveness trial of family therapy for adolescent drug abuse highlights the importance of treatment fidelity and qualitative approaches to examining it. In this sense, echoing the history of family therapy research, our experience with juxtaposing quantitative and qualitative methods has gone full circle-from qualitative to quantitative observation and back again.

  5. Evidence for an exotic magnetic transition in the triangular spin system FeGa2S4

    Science.gov (United States)

    Dalmas de Réotier, P.; Yaouanc, A.; MacLaughlin, D. E.; Zhao, Songrui; Higo, T.; Nakatsuji, S.; Nambu, Y.; Marin, C.; Lapertot, G.; Amato, A.; Baines, C.

    2012-04-01

    We report positive muon spin relaxation measurements on the triangular lattice magnetic system FeGa2S4. A magnetic transition that, to the best of our knowledge, has not been previously detected by specific-heat and magnetic susceptibility measurements is found in zero field at T*≃30 K. It is observed through the temperature dependencies of the signal amplitude and the spin-lattice relaxation rate. This transition is therefore not a conventional magnetic phase transition. Since persistent spin dynamics is observed down to 0.1 K, the ground state cannot be of the canonical spin-glass type, which could be suggested from hysteresis effects in the bulk susceptibility below Tf≃16 K. These results are compared to those found for the isomorph NiGa2S4. It is argued that the fate of the transition, which has been interpreted in terms of the Z2 topological transition in this latter system, is probably different in FeGa2S4.

  6. Pupillometric evidence for the locus coeruleus-noradrenaline system facilitating attentional processing of action-triggered visual stimuli

    Directory of Open Access Journals (Sweden)

    Ken eKihara

    2015-06-01

    Full Text Available It has been argued that attentional processing of visual stimuli is facilitated by a voluntary action that triggers the stimulus onset. However, the relationship between action-induced facilitation of attention and the neural substrates has not been well established. The present study investigated whether the locus coeruleus-noradrenaline (LC-NA system is involved in this facilitation effect. A rapid serial visual presentation paradigm was used to assess the dynamics of transient attention in humans. Participants were instructed to change a digit stream to a letter stream by pressing a button and specifying successive targets of four letters. Pupil dilation was measured as an index of LC-NA function. Accuracy of target identification was better when the temporal delay between participants' key press and target onset was 800 ms than when targets appeared just after the key press or when targets appeared without key press. Accuracy of target identification was positively correlated with both the peak amplitude of pupil dilation and the pupil size at the time of the key press. These results indicate that target identification in the visual task is closely linked to pupil dilation. We conclude that the LC-NA system plays an important role in the facilitation of transient attention driven by voluntary action.

  7. The Examination of the Corporate Governance System at Supplier Companies: Empirical Evidence from Hungarian Automotive Industry Ercsey Ida

    Directory of Open Access Journals (Sweden)

    Ercsey Ida

    2016-06-01

    Full Text Available Information management and the organizational structure can contribute to the firms’ competitive advantage and business success. In the first part of our study we summarize the results we obtained by analyzing the corporate governance system in connection with the structure of enterprises and their decision making. Then we have an insight into the leadership style of the suppliers from the point of view of the participation of the staff in decision making. In the second part we analyze the information management of the supplier companies on the basis of the answers from the management. We evaluate the strategic and the operational concept of information management, proceeding from the strategy-making activity. The accomplishment of permanent renewal and willingness to innovate are both indispensable for achieving elasticity in organizations. We explore how the suppliers introduce innovation in connection with the firm structure and the information system. Finally, we consider how some essential company characteristics, namely company size, ownership, region, and the width of the product assortment, affect various company functions.

  8. Molecular Evidence for Convergence and Parallelism in Evolution of Complex Brains of Cephalopod Molluscs: Insights from Visual Systems.

    Science.gov (United States)

    Yoshida, M A; Ogura, A; Ikeo, K; Shigeno, S; Moritaki, T; Winters, G C; Kohn, A B; Moroz, L L

    2015-12-01

    Coleoid cephalopods show remarkable evolutionary convergence with vertebrates in their neural organization, including (1) eyes and visual system with optic lobes, (2) specialized parts of the brain controlling learning and memory, such as vertical lobes, and (3) unique vasculature supporting such complexity of the central nervous system. We performed deep sequencing of eye transcriptomes of pygmy squids (Idiosepius paradoxus) and chambered nautiluses (Nautilus pompilius) to decipher the molecular basis of convergent evolution in cephalopods. RNA-seq was complemented by in situ hybridization to localize the expression of selected genes. We found three types of genomic innovations in the evolution of complex brains: (1) recruitment of novel genes into morphogenetic pathways, (2) recombination of various coding and regulatory regions of different genes, often called "evolutionary tinkering" or "co-option", and (3) duplication and divergence of genes. Massive recruitment of novel genes occurred in the evolution of the "camera" eye from nautilus' "pinhole" eye. We also showed that the type-2 co-option of transcription factors played important roles in the evolution of the lens and visual neurons. In summary, the cephalopod convergent morphological evolution of the camera eyes was driven by a mosaic of all types of gene recruitments. In addition, our analysis revealed unexpected variations of squids' opsins, retinochromes, and arrestins, providing more detailed information, valuable for further research on intra-ocular and extra-ocular photoreception of the cephalopods.

  9. Pupillometric evidence for the locus coeruleus-noradrenaline system facilitating attentional processing of action-triggered visual stimuli.

    Science.gov (United States)

    Kihara, Ken; Takeuchi, Tatsuto; Yoshimoto, Sanae; Kondo, Hirohito M; Kawahara, Jun I

    2015-01-01

    It has been argued that attentional processing of visual stimuli is facilitated by a voluntary action that triggers the stimulus onset. However, the relationship between action-induced facilitation of attention and the neural substrates has not been well established. The present study investigated whether the locus coeruleus-noradrenaline (LC-NA) system is involved in this facilitation effect. A rapid serial visual presentation paradigm was used to assess the dynamics of transient attention in humans. Participants were instructed to change a digit stream to a letter stream by pressing a button and specifying successive targets of four letters. Pupil dilation was measured as an index of LC-NA function. Accuracy of target identification was better when the temporal delay between participants' key press and target onset was 800 ms than when targets appeared just after the key press or when targets appeared without key press. Accuracy of target identification was positively correlated with both the peak amplitude of pupil dilation and the pupil size at the time of the key press. These results indicate that target identification in the visual task is closely linked to pupil dilation. We conclude that the LC-NA system plays an important role in the facilitation of transient attention driven by voluntary action.

  10. [Violence and accidents among older and younger adults: evidence from the Surveillance System for Violence and Accidents (VIVA), Brazil].

    Science.gov (United States)

    Luz, Tatiana Chama Borges; Malta, Deborah Carvalho; Sá, Naíza Nayla Bandeira de; Silva, Marta Maria Alves da; Lima-Costa, Maria Fernanda

    2011-11-01

    Data from the Brazilian Surveillance System for Violence and Accidents (VIVA) in 2009 were used to examine socio-demographic characteristics, outcomes, and types of accidents and violence treated at 74 sentinel emergency services in 23 Brazilian State capitals and the Federal District. The analysis included 25,201 individuals aged > 20 years (10.1% > 60 years); 89.3% were victims of accidents and 11.9% victims of violence. Hospitalization was the outcome in 11.1% of cases. Compared to the general population, there were more men and non-white individuals among victims of accidents, and especially among victims of violence. As compared to younger adults (20-59 years), accidents and violence against elderly victims showed less association with alcohol, a higher proportion of domestic incidents, more falls and pedestrian accidents, and aggression by family members. Policies for the prevention of accidents and violence should consider the characteristics of these events in the older population.

  11. Surface imprint of toroidal flow at retreating slab edges: The first geodetic evidence in the Calabrian subduction system

    Science.gov (United States)

    Palano, M.; Piromallo, C.; Chiarabba, C.

    2017-01-01

    Dense GPS observations can help Earth scientists to capture the surface imprint of mantle toroidal flow at slab edges. We document this process in the Calabrian subduction system, where the Ionian slab rollback took place during the past 30 Ma, following a stepwise process driven by migration of lithospheric tearing. We found rotation rates of 1.29°/Ma (counterclockwise) and 1.74°/Ma (clockwise), for poles located close to the northern and southern slab edges, respectively. These small-scale, opposite rotations occur along complex sets of active faults representing the present-day lithospheric expression of the tearing processes affecting the southeastward retreating Ionian slab at both edges. The observed rotations are likely still young and the process more immature at the northern tear, where it is unable to reorient mantle fabric and therefore is unseen by SKS splitting.

  12. Research on early warning of food security using a system dynamics model: evidence from Jiangsu province in China.

    Science.gov (United States)

    Xu, Jianling; Ding, Yi

    2015-01-01

    Analyzing the early warning of food security, this paper sets the self-sufficiency rate as the principal indicator in a standpoint of supplement. It is common to use the quantitative methods to forecast and warning the insecurity. However, this paper considers more about the probable outcome when the government intervenes. By constructing the causal feedbacks among grain supplement, demand, productive input, and the policy factors to simulate the future food security in Jiangsu province, conclusions can be drawn as the following: (1) The situation of food security is insecure if the self-sufficiency rate is under 68.3% according to the development of system inertia. (2) it is difficult to guarantee the food security in Jiangsu just depending on the increase of grain sown area. (3) The valid solution to ensure the food security in Jiangsu is to improve the productivity.

  13. Archaeological Evidence for Resilience of Pacific Northwest Salmon Populations and the Socioecological System over the last ~7,500 years

    Directory of Open Access Journals (Sweden)

    Sarah K. Campbell

    2010-03-01

    Full Text Available Archaeological data on the long history of interaction between indigenous people and salmon have rarely been applied to conservation management. When joined with ethnohistoric records, archaeology provides an alternative conceptual view of the potential for sustainable harvests and can suggest possible social mechanisms for managing human behavior. Review of the ~7,500-year-long fish bone record from two subregions of the Pacific Northwest shows remarkable stability in salmon use. As major changes in the ecological and social system occurred over this lengthy period, persistence in the fishery is not due simply to a lack of perturbation, but rather indicates resilience in the ecological-human system. Of several factors possibly contributing to resilience, low human population size and harvesting pressure, habitat enhancement, and suppression of competing predators do not appear to be of major importance. Flexible resource use, including human use of a range of local resources, many of which are linked in a food web with salmon, likely contributed to resilience. Most important were the beliefs and social institutions (including ownership, regulation, rituals, and monitoring that placed restraints on salmon use as a common pool resource. In contrast, only a small fraction of our modern society relies economically on or has direct interaction with the fish, which limits our concern and willingness to fundamentally change behaviors that contribute to habitat degradation and loss, the main challenges facing salmon populations today. Salmon recovery efforts may benefit substantially from investing more resources into establishing links between community groups and actual fish populations, which would create a sense of proprietorship, one of the keys to resilience in the indigenous salmon fishery.

  14. Meta-analytic evidence for decreased heart rate variability in chronic pain implicating parasympathetic nervous system dysregulation.

    Science.gov (United States)

    Tracy, Lincoln M; Ioannou, Liane; Baker, Katharine S; Gibson, Stephen J; Georgiou-Karistianis, Nellie; Giummarra, Melita J

    2016-01-01

    Both sympathetic and parasympathetic nervous systems are involved in regulating pain states. The activity of these systems seems to become disturbed in states of chronic pain. This disruption in autonomic balance can be measured through the assessment of heart rate variability (HRV), that is, the variability of the interval between consecutive heart beats. However, there is yet to be a systematic evaluation of the body of literature concerning HRV across several chronic pain conditions. Moreover, modern meta-analytical techniques have never been used to validate and consolidate the extent to which HRV may be decreased in chronic pain. Following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement guidelines, this study systematically evaluated and critically appraised the literature concerning HRV in people living with chronic pain. After screening 17,350 sources, 51 studies evaluating HRV in a chronic pain group met the inclusion criteria. Twenty-six moderate-high quality studies were included in quantitative meta-analyses. On average, the quality of studies was moderate. There were 6 frequency-domain and time-domain measures of HRV across a broad range of chronic pain conditions. High heterogeneity aside, pooled results from the meta-analyses reflected a consistent, moderate-to-large effect of decreased high-frequency HRV in chronic pain, implicating a decrease in parasympathetic activation. These effects were heavily influenced by fibromyalgia studies. Future research would benefit from wider use of standardised definitions of measurement, and also investigating the synergistic changes in pain state and HRV throughout the development and implementation of mechanism-based treatments for chronic pain.

  15. The hydrothermal system of the Domuyo volcanic complex (Argentina): A conceptual model based on new geochemical and isotopic evidences

    Science.gov (United States)

    Tassi, F.; Liccioli, C.; Agusto, M.; Chiodini, G.; Vaselli, O.; Calabrese, S.; Pecoraino, G.; Tempesti, L.; Caponi, C.; Fiebig, J.; Caliro, S.; Caselli, A.

    2016-12-01

    The Domuyo volcanic complex (Neuquén Province, Argentina) hosts one of the most promising geothermal systems of Patagonia, giving rise to thermal manifestations discharging hot and Cl--rich fluids. This study reports a complete geochemical dataset of gas and water samples collected in three years (2013, 2014 and 2015) from the main fluid discharges of this area. The chemical and isotopic composition (δD-H2O and δ18O-H2O) of waters indicates that rainwater and snow melting are the primary recharge of a hydrothermal reservoir located at relative shallow depth (400-600 m) possibly connected to a second deeper (2-3 km) reservoir. Reactive magmatic gases are completely scrubbed by the hydrothermal aquifer(s), whereas interaction of meteoric waters at the surface causes a significant air contamination and dilution of the fluid discharges located along the creeks at the foothill of the Cerro Domuyo edifice. Thermal discharges located at relatively high altitude ( 3150 m a.s.l.), namely Bramadora, are less affected by this process, as also shown by their relatively high R/Ra values (up to 6.91) pointing to the occurrence of an actively degassing magma batch located at an unknown depth. Gas and solute geothermometry suggests equilibrium temperatures up to 220-240 °C likely referred to the shallower hydrothermal reservoir. These results, confirming the promising indications of the preliminary surveys carried out in the 1980‧s, provide useful information for a reliable estimation of the geothermal potential of this extinct volcanic system, although a detailed geophysical measurements is required for the correct estimation of depth and dimensions of the fluid reservoir(s).

  16. Evidence for the involvement of the CXCL12 system in the adaptation of skeletal muscles to physical exercise.

    Science.gov (United States)

    Puchert, Malte; Adams, Volker; Linke, Axel; Engele, Jürgen

    2016-09-01

    The chemokine CXCL12 and its primary receptor, CXCR4, not only promote developmental myogenesis, but also muscle regeneration. CXCL12 chemoattracts CXCR4-positive satellite cells/blood-borne progenitors to the injured muscle, promotes myoblast fusion, partially with existing myofibers, and induces angiogenesis in regenerating muscles. Interestingly, the mechanisms underlying muscle regeneration are in part identical to those involved in muscular adaptation to intensive physical exercise. These similarities now prompted us to determine whether physical exercise would impact the CXCL12 system in skeletal muscle. We found that CXCL12 and CXCR4 are upregulated in the gastrocnemius muscle of rats that underwent a four-week period of constrained daily running exercise on a treadmill. Double-staining experiments confirmed that CXCL12 and CXCR4 are predominantly expressed in MyHC-positive muscle fibers. Moreover, these training-dependent increases in CXCL12 and CXCR4 expression also occurred in rats with surgical coronary artery occlusion, implying that the muscular CXCL12 system is still active in skeletal myopathy resulting from chronic heart failure. Expression of the second CXCL12 receptor, CXCR7, which presumably acts as a scavenger receptor in muscle, was not affected by training. Attempts to dissect the molecular events underlying the training-dependent effects of CXCL12 revealed that the CXCL12-CXCR4 axis activates anabolic mTOR-p70S6K signaling and prevents upregulation of the catabolic ubiquitin ligase MurF-1 in C2C12 myotubes, eventually increasing myotube diameters. Together, these findings point to a pivotal role of the CXCL12-CXCR4 axis in exercise-induced muscle maintenance and/or growth.

  17. THE EFFECT OF E-COMMERCE ON MALAYSIAN TAX SYSTEM: AN EMPIRICAL EVIDENCE FROM ACADEMICIANS AND MALAYSIAN TAX PRACTITIONERS

    Directory of Open Access Journals (Sweden)

    Mohd Rizal Palil

    2004-01-01

    Full Text Available The explosion of information technology (IT nowadays has created new phenomena in shopping activities. Consumers can easily buy products via Internet. Within a minute, the products will be delivered instantly and accurately. This scenario is known as e-commerce. The emergence of e-commerce affects consumers' shopping behavior as well as taxation system. The objective of this research is to reveal the effects of e-commerce upon Malaysian taxation system by emphasizing in scope of charge 'derive and remittance'. Research was conducted through questionnaires of 82 tax practitioners and 22 academicians. The research findings shown that derive and remittance basis is no longer appropriate in e-commerce environment. Scope of charge derives and remittances, which are practicing in Malaysia right now, are unable to maximized e-commerce tax revenue. Abstract in Bahasa Indonesia : Perkembangan dalam dunia teknologi akhir-akhir ini telah membawa banyak arus perubahan terutamanya dalam aktivitas belanja. Konsumen dapat membeli barang dengan mudah melalui internet. Dalam waktu beberapa menit, barang sampai di tangan konsumen. Skenario demikian dikenal sebagai perdagangan elektronis. Kemunculan perdagangan elektronis mengubah prilaku belanja konsumen serta sistem perpajakan di Malaysia. Tujuan penelitian ini adalah untuk mengetahui efek perdagangan elektronis terhadap sistem perpajakan di Malaysia dengan penekanan pada pengenaan pajak dan hak pemajakan. Penelitian dilakukan dengan menggunakan 82 sample praktisi perpajakan dan 22 akademisi. Hasil penelitian menunjukkan, bahwa praktek pengenaan pajak dalam perdagangan elektronis belum sesuai dengan aturan yang berlaku, sehingga tidak dapat memaksimalkan penerimaan pajak dari perdagangan elektronis. Kata kunci: sistem perpajakan Malaysia, perdagangan elektronik, akademik, praktisi perpajakan, pengenaan pajak.

  18. Chemical properties of rain events during the AMMA campaign: an evidence of dust and biogenic influence in the convective systems

    Directory of Open Access Journals (Sweden)

    K. Desboeufs

    2010-06-01

    Full Text Available This paper documents the chemical composition of 7 rain events associated with mesoscale convective systems sampled at the supersite of Banizoumbou, Niger, during the first special observation periods (June–July 2006 of the African Monsoon Multidisciplinary Analyses (AMMA experiment. Time-resolved rain sampling was performed in order to discriminate the local dust scavenged at the beginning of rain event from the aerosol particles incorporated in the cloud at the end of the rain. The total elemental composition is dominated by Al, Si, Fe and Ca, indicating a high influence of dust and limited marine or anthropogenic contribution. After the aerosol wash-out, the elemental concentrations normalized to Al and the microscopic observations of diatoms, a tracer of the Bodélé depression, both indicate that the total elemental composition of rainwater is controlled by dust originating from North-Eastern Saharan sources and probably incorporated in the convective cloud from the Harmattan layer. The low variability of the rain composition over the measurement period indicates a regional and temporal homogeneity of dust composition in the Harmattan layer. In the dissolved phase, the dominant anions are nitrate (NO3, sulphate (SO42− and chloride (Cl. However, between June and July we observe an increasing contribution of the organic anions (formate, acetate, oxalate associated with biogenic emissions to the total ion composition. These results confirm the large influence of biogenic emissions on the rain composition over Sahel during the wet season. The paper concludes on the capacity of mesoscale convective systems to carry simultaneously dust and biogenic compounds originating from different locations and depose them jointly. It also discusses the potential biogeochemical impact of such a phenomenon.

  19. Electrophysiological evidence for the involvement of the approximate number system in preschoolers' processing of spoken number words.

    Science.gov (United States)

    Pinhas, Michal; Donohue, Sarah E; Woldorff, Marty G; Brannon, Elizabeth M

    2014-09-01

    Little is known about the neural underpinnings of number word comprehension in young children. Here we investigated the neural processing of these words during the crucial developmental window in which children learn their meanings and asked whether such processing relies on the Approximate Number System. ERPs were recorded as 3- to 5-year-old children heard the words one, two, three, or six while looking at pictures of 1, 2, 3, or 6 objects. The auditory number word was incongruent with the number of visual objects on half the trials and congruent on the other half. Children's number word comprehension predicted their ERP incongruency effects. Specifically, children with the least number word knowledge did not show any ERP incongruency effects, whereas those with intermediate and high number word knowledge showed an enhanced, negative polarity incongruency response (N(inc)) over centroparietal sites from 200 to 500 msec after the number word onset. This negativity was followed by an enhanced, positive polarity incongruency effect (P(inc)) that emerged bilaterally over parietal sites at about 700 msec. Moreover, children with the most number word knowledge showed ratio dependence in the P(inc) (larger for greater compared with smaller numerical mismatches), a hallmark of the Approximate Number System. Importantly, a similar modulation of the P(inc) from 700 to 800 msec was found in children with intermediate number word knowledge. These results provide the first neural correlates of spoken number word comprehension in preschoolers and are consistent with the view that children map number words onto approximate number representations before they fully master the verbal count list.

  20. Detection of Vaccinia Virus in Milk: Evidence of a Systemic and Persistent Infection in Experimentally Infected Cows.

    Science.gov (United States)

    de Oliveira, Tércia Moreira Ludolfo; Guedes, Maria Isabel Maldonado Coelho; Rehfeld, Izabelle Silva; Matos, Ana Carolina Diniz; Rivetti, Anselmo Vasconcelos; Alves, Pedro Augusto; Galinari, Grazielle Cossenzo Florentino; Cerqueira, Mônica Maria Oliveira Pinho; Abrahão, Jônatas Santos; Lobato, Zélia Inês Portela

    2015-11-01

    Bovine vaccinia (BV) is a zoonosis caused by Vaccinia virus (VACV), which affects lactating cows and milkers. VACV DNA and infectious particles have been detected in milk of naturally infected cows. However, the period and pattern of VACV shedding in milk is unknown, as is whether the presence of VACV in milk is due to a localized or a systemic infection. To address those questions, eight lactating cows were inoculated with VACV in previously scarified teats. The experiment was divided in two phases. In Phase 1, milk samples were collected daily for 33 days, and in Phase 2, four animals from the first phase were immunosuppressed. In both phases, milk was collected with a sterile catheter on even days and by hand milking on odd days. All animals showed typical BV lesions in the inoculated teats. All milk samples were subjected to nested polymerase chain reaction (PCR) and real-time quantitative PCR to detect VACV DNA. PCR-positive samples were subjected to virus isolation. VACV DNA was intermittently detected in milk in both phases and infectious viral particles could be detected only in phase 2, on the 69th, 73rd, 74th, 77th, 79th, and 81st days postinfection. Despite the possibility of propagation of VACV through milk, it is known that milk continues to be drawn and marketed normally during outbreaks of the disease. The detection of both VACV DNA and infectious particles in milk samples draws attention to the potential public health risk associated with the consumption of milk from BV outbreaks. Detection of VACV in the milk from noninfected teats demonstrated that VACV shedding in milk might be related to a systemic infection. Moreover, it was shown that VACV DNA and viral infectious particles could be detected in milk even after healing of the lesions, demonstrating that VACV may cause a persistent infection in cattle.

  1. Category number impacts rule-based and information-integration category learning: a reassessment of evidence for dissociable category-learning systems.

    Science.gov (United States)

    Stanton, Roger D; Nosofsky, Robert M

    2013-07-01

    Researchers have proposed that an explicit reasoning system is responsible for learning rule-based category structures and that a separate implicit, procedural-learning system is responsible for learning information-integration category structures. As evidence for this multiple-system hypothesis, researchers report a dissociation based on category-number manipulations in which rule-based category learning is worse when the category is composed of 4, rather than 2, response categories; however, information-integration category learning is unaffected by category-number manipulations. We argue that within the reported category-number manipulations, there exists a critical confound: Perceptual clusters used to construct the categories are spread apart in the 4-category condition relative to the 2-category one. The present research shows that when this confound is eliminated, performance on information-integration category learning is worse for 4 categories than for 2 categories, and this finding is demonstrated across 2 different information-integration category structures. Furthermore, model-based analyses indicate that a single-system learning model accounts well for both the original findings and the updated experimental findings reported here.

  2. The Early Diagnosis of Boys and Girls in Academic Risk Using the Perceptual-Motor Diagnostic System: A Longitudinal Retrospective Study of Evidences of its Effectiveness

    Directory of Open Access Journals (Sweden)

    Emmanuel Herrera-González

    2015-09-01

    Full Text Available The main objective in this study is to evidence the efficiency of the Peques System as a useful tool to diagnose, at an early stage, possible difficulties which will affect the academic performance. In a 3-year longitudinal study, the Perceptual-Motor Diagnostic System (Peques was applied to a sample of 149 participants (77 boys and 72 girls, who were beginning preschool education. Peques classified 38 children with a high risk to lose a year at primary school level. After a three-year follow-up (first primary school level, it was determined that 23 of the 127 who remained in the study (18%, had failed the first, second or third school year. From the high-risk group diagnosed by the Peques System, an 83% indeed lost a school year. These boys and girls had difficulties in different aspects, such as their information processing capacity, motor development, corporal image, Gestalt development and corporal coordination. We concluded that Peques System was able to predict the academic failure in the primary school level, based on the perceptual-motor development reached at preschool level. Further, based on this experience it is recommended to pay special attention to perceptual-motor development, since it plays a basic role in the academic success of boys and girls.

  3. The Border Ranges fault system in Glacier Bay National Park, Alaska: Evidence for major early Cenozoic dextral strike-slip motion

    Science.gov (United States)

    Smart, K.J.; Pavlis, T.L.; Sisson, V.B.; Roeske, S.M.; Snee, L.W.

    1996-01-01

    The Border Ranges fault system of southern Alaska, the fundamental break between the arc basement and the forearc accretionary complex, is the boundary between the Peninsular-Alexander-Wrangellia terrane and the Chugach terrane. The fault system separates crystalline rocks of the Alexander terrane from metamorphic rocks of the Chugach terrane in Glacier Bay National Park. Mylonitic rocks in the zone record abundant evidence for dextral strike-slip motion along north-northwest-striking subvertical surfaces. Geochronologic data together with regional correlations of Chugach terrane rocks involved in the deformation constrain this movement between latest Cretaceous and Early Eocene (???50 Ma). These findings are in agreement with studies to the northwest and southeast along the Border Ranges fault system which show dextral strike-slip motion occurring between 58 and 50 Ma. Correlations between Glacier Bay plutons and rocks of similar ages elsewhere along the Border Ranges fault system suggest that as much as 700 km of dextral motion may have been accommodated by this structure. These observations are consistent with oblique convergence of the Kula plate during early Cenozoic and forearc slivering above an ancient subduction zone following late Mesozoic accretion of the Peninsular-Alexander-Wrangellia terrane to North America.

  4. Influences of Electromagnetic Energy on Bio-Energy Transport through Protein Molecules in Living Systems and Its Experimental Evidence.

    Science.gov (United States)

    Pang, Xiaofeng; Chen, Shude; Wang, Xianghui; Zhong, Lisheng

    2016-07-25

    The influences of electromagnetic fields (EMFs) on bio-energy transport and its mechanism of changes are investigated through analytic and numerical simulation and experimentation. Bio-energy transport along protein molecules is performed by soliton movement caused by the dipole-dipole electric interactions between neighboring amino acid residues. As such, EMFs can affect the structure of protein molecules and change the properties of the bio-energy transported in living systems. This mechanism of biological effect from EMFs involves the amino acid residues in protein molecules. To study and reveal this mechanism, we simulated numerically the features of the movement of solitons along protein molecules with both a single chain and with three channels by using the Runge-Kutta method and Pang's soliton model under the action of EMFs with the strengths of 25,500, 51,000, 76,500, and 102,000 V/m in the single-chain protein, as well as 17,000, 25,500, and 34,000 V/m in the three-chain protein, respectively. Results indicate that electric fields (EFs) depress the binding energy of the soliton, decrease its amplitude, and change its wave form. Also, the soliton disperses at 102,000 V/m in a single-chain protein and at 25,500 and 34,000 V/m in three-chain proteins. These findings signify that the influence of EMFs on the bio-energy transport cannot be neglected; however, these variations depend on both the strength and the direction of the EF in the EMF. This direction influences the biological effects of EMF, which decrease with increases in the angle between the direction of the EF and that of the dipole moment of amino acid residues; however, randomness at the macroscopic level remains. Lastly, we experimentally confirm the existence of a soliton and the validity of our conclusion by using the infrared spectra of absorption of the collagens, which is activated by another type of EF. Thus, we can affirm that both the described mechanism and the corresponding theory are

  5. Influences of Electromagnetic Energy on Bio-Energy Transport through Protein Molecules in Living Systems and Its Experimental Evidence

    Directory of Open Access Journals (Sweden)

    Xiaofeng Pang

    2016-07-01

    Full Text Available The influences of electromagnetic fields (EMFs on bio-energy transport and its mechanism of changes are investigated through analytic and numerical simulation and experimentation. Bio-energy transport along protein molecules is performed by soliton movement caused by the dipole–dipole electric interactions between neighboring amino acid residues. As such, EMFs can affect the structure of protein molecules and change the properties of the bio-energy transported in living systems. This mechanism of biological effect from EMFs involves the amino acid residues in protein molecules. To study and reveal this mechanism, we simulated numerically the features of the movement of solitons along protein molecules with both a single chain and with three channels by using the Runge–Kutta method and Pang’s soliton model under the action of EMFs with the strengths of 25,500, 51,000, 76,500, and 102,000 V/m in the single-chain protein, as well as 17,000, 25,500, and 34,000 V/m in the three-chain protein, respectively. Results indicate that electric fields (EFs depress the binding energy of the soliton, decrease its amplitude, and change its wave form. Also, the soliton disperses at 102,000 V/m in a single-chain protein and at 25,500 and 34,000 V/m in three-chain proteins. These findings signify that the influence of EMFs on the bio-energy transport cannot be neglected; however, these variations depend on both the strength and the direction of the EF in the EMF. This direction influences the biological effects of EMF, which decrease with increases in the angle between the direction of the EF and that of the dipole moment of amino acid residues; however, randomness at the macroscopic level remains. Lastly, we experimentally confirm the existence of a soliton and the validity of our conclusion by using the infrared spectra of absorption of the collagens, which is activated by another type of EF. Thus, we can affirm that both the described mechanism and the

  6. Antidepressant-like effect of the organoselenium compound ebselen in mice: evidence for the involvement of the monoaminergic system.

    Science.gov (United States)

    Posser, Thaís; Kaster, Manuella P; Baraúna, Sara Cristiane; Rocha, João B T; Rodrigues, Ana Lúcia S; Leal, Rodrigo B

    2009-01-05

    Ebselen [2-phenyl-1,2-benzisoselenazol-3(2H)-one] is a seleno-organic compound which possesses a potent antioxidant activity and has been shown to exert neuroprotective effects in vitro and in vivo in a variety of pro-oxidative insults. The present study investigates a possible antidepressant activity of ebselen using two predictive tests for antidepressant activity in rodents: the forced swimming test and tail suspension test. Additionally, the mechanisms involved in the antidepressant-like effect of ebselen in mice were also assessed. Ebselen (10 mg/kg, s.c.) decreased the immobility time in the forced swimming test without accompanying changes in ambulation in the open-field test. In contrast, the administration of ebselen (10-30 mg/kg) did not produce any effect in the tail suspension test. The anti-immobility effect of ebselen (10 mg/kg, s.c.) was not prevented by pre-treatment of mice with p-chlorophenylalanine (PCPA, 100 mg/kg, i.p., an inhibitor of serotonin synthesis, 4 consecutive days), NAN-190 (0.5 mg/kg, i.p., a serotonin 5-HT(1A) receptor antagonist) or ketanserin (5 mg/kg, i.p., a serotonin 5-HT(2A/2C) receptor antagonist). On the other hand, the pre-treatment of mice with prazosin (1 mg/kg, i.p., an alpha(1)-adrenoceptor antagonist), yohimbine (1 mg/kg, i.p., an alpha(2)-adrenoceptor antagonist), SCH23390 (0.05 mg/kg, s.c., a dopamine D(1) receptor antagonist) or sulpiride (50 mg/kg, i.p., a dopamine D(2) receptor antagonist) completely blocked the antidepressant-like effect of ebselen (10 mg/kg, s.c.) in the forced swimming test. It may be concluded that ebselen produces an antidepressant-like effect in the forced swimming test that seems to be dependent on its interaction with the noradrenergic and dopaminergic systems, but not with the serotonergic system.

  7. Rigidity Emerges during Antibody Evolution in Three Distinct Antibody Systems: Evidence from QSFR Analysis of Fab Fragments.

    Directory of Open Access Journals (Sweden)

    Tong Li

    2015-07-01

    Full Text Available The effects of somatic mutations that transform polyspecific germline (GL antibodies to affinity mature (AM antibodies with monospecificity are compared among three GL-AM Fab pairs. In particular, changes in conformational flexibility are assessed using a Distance Constraint Model (DCM. We have previously established that the DCM can be robustly applied across a series of antibody fragments (VL to Fab, and subsequently, the DCM was combined with molecular dynamics (MD simulations to similarly characterize five thermostabilizing scFv mutants. The DCM is an ensemble based statistical mechanical approach that accounts for enthalpy/entropy compensation due to network rigidity, which has been quite successful in elucidating conformational flexibility and Quantitative Stability/Flexibility Relationships (QSFR in proteins. Applied to three disparate antibody systems changes in QSFR quantities indicate that the VH domain is typically rigidified, whereas the VL domain and CDR L2 loop become more flexible during affinity maturation. The increase in CDR H3 loop rigidity is consistent with other studies in the literature. The redistribution of conformational flexibility is largely controlled by nonspecific changes in the H-bond network, although certain Arg to Asp salt bridges create highly localized rigidity increases. Taken together, these results reveal an intricate flexibility/rigidity response that accompanies affinity maturation.

  8. Evidence for Two Phases of Galaxy Formation from Radial Trends in the Globular Cluster System of NGC 1407

    CERN Document Server

    Forbes, Duncan; Strader, Jay; Romanowsky, Aaron; Brodie, Jean; Foster, Caroline

    2011-01-01

    Here we present the colours of individual globular clusters (GCs) around the massive elliptical galaxy NGC 1407 out to a projected galactocentric radius of 140 kpc or 17 galaxy effective radii (R$_e$). Such data are a proxy for the halo metallicity. We find steep, and similar, metallicity gradients of ~ -0.4 dex per dex for both the blue (metal-poor) and red (metal-rich) GC subpopulations within 5-8.5 R_e (40-70 kpc). At larger radii the mean GC colours (metallicity) are constant. A similar behaviour is seen in a wide-field study of M87's GC system, and in our own Galaxy. We interpret these radial metallicity trends to indicate an inner region formed by early in-situ dissipative processes and an outer halo formed by ongoing accretion of low mass galaxies and their GCs. These results provide observational support for the model of galaxy formation whereby massive galaxies form inside-out in two phases. We have also searched the literature for other massive early-type galaxies with reported GC metallicity gradie...

  9. Beyond sodefrin: evidence for a multi-component pheromone system in the model newt Cynops pyrrhogaster (Salamandridae).

    Science.gov (United States)

    Van Bocxlaer, Ines; Maex, Margo; Treer, Dag; Janssenswillen, Sunita; Janssens, Rik; Vandebergh, Wim; Proost, Paul; Bossuyt, Franky

    2016-03-03

    Sodefrin, a decapeptide isolated from the male dorsal gland of the Japanese fire belly newt Cynops pyrrhogaster, was the first peptide pheromone identified from a vertebrate. The fire belly salamander and sodefrin have become a model for sex pheromone investigation in aquatically courting salamanders ever since. Subsequent studies in other salamanders identified SPF protein courtship pheromones of around 20 kDa belonging to the same gene-family. Although transcripts of these proteins could be PCR-amplified in Cynops, it is currently unknown whether they effectively use full-length SPF pheromones next to sodefrin. Here we combined transcriptomics, proteomics and phylogenetics to investigate SPF pheromone use in Cynops pyrrhogaster. Our data show that not sodefrin transcripts, but multiple SPF transcripts make up the majority of the expression profile in the dorsal gland of this newt. Proteome analyses of water in which a male has been courting confirm that this protein blend is effectively secreted and tail-fanned to the female. By combining phylogenetics and expression data, we show that independent evolutionary lineages of these SPF's were already expressed in ancestral Cynops species before the origin of sodefrin. Extant Cynops species continue to use this multi-component pheromone system, consisting of various proteins in addition to a lineage-specific peptide.

  10. The utility of the cognitive-affective processing system in the diagnosis of personality disorders: some preliminary evidence.

    Science.gov (United States)

    Rhadigan, Cortney; Huprich, Steven K

    2012-04-01

    The Cognitive-Affective Processing System (CAPS) suggests that personality is best understood as a collection of situationally consistent traits that are expressed contingent upon features of the situation that elicit them. This differs from the Five-Factor Model (FFM) of personality, in which personality is believed to be composed of five broad trait domains that are observed consistently across multiple situations. In this study, 202 licensed members of a state psychological association assigned diagnoses to written case studies that were created out of situationally specific descriptions of Axis II criteria. The accuracy of these diagnoses were compared to case studies written from FFM trait descriptions representative of the same Axis II disorders (schizoid, narcissistic, and obsessive compulsive) and to case studies taken from published DSM case books. Results demonstrated that cases constructed with the CAPS descriptions yielded more accurate diagnoses in two of the three cases compared to FFM trait description cases and equivalent diagnostic accuracy when using the DSM-IV. Based on these initial findings, it appears that clinicians may be able to judge personality disorders better with situationally specific, or context-dependent, information than simple trait descriptions.

  11. Antidepressant-like effect of riparin II from Aniba riparia in mice: evidence for the involvement of the monoaminergic system.

    Science.gov (United States)

    Teixeira, Caroline Porto Leite; de Melo, Carla Thiciane Vasconcelos; de Araújo, Fernando Luiz Oliveira; de Carvalho, Allyne Mara Rodrigues; Silva, Maria Izabel Gomes; Barbosa-Filho, José Maria; Macêdo, Danielle Silveira; de Barros Viana, Glauce Socorro; de Sousa, Francisca Cléa Florenço

    2013-04-01

    In a previous study conducted by our group, riparin II (ripII) isolated from the green fruit of Aniba riparia presented antianxiety effects in mice. This study investigates a possible antidepressant activity of rip II using two predictive tests for antidepressant activity in rodents: the forced swimming test (FST) and tail suspension test (TST). Additionally, the mechanisms involved in the antidepressant-like effect in mice were also assessed. Rip II was acute administered by intraperitoneal (i.p.) and oral (p.o) routes to male mice at doses of 25 and 50 mg/kg. Results showed that ripII at both tested doses and administration routes produced a significant decrease of immobility time in FST and TST. The pretreatment of mice with prazosin (1 mg/kg, i.p., an α1-adrenoceptor antagonist), SCH23390 (15 μg/kg, i.p., a dopamine D1 receptor antagonist), sulpiride (50 mg/kg, i.p., a dopamine D2 receptor antagonist), p-chlorophenylalanine (100 mg/kg, an inhibitor of serotonin synthesis), or NAN-190 (0.5 mg/kg, a serotonin 5-HT1A receptor antagonist) completely blocked the anti-immobility effects elicited by riparin II (50 mg/kg, p.o.) in the FST. This study indicates that riparin II produces significant antidepressant-like activity in the forced swimming and TSTs, and this effect seems to be dependent on its interaction with noradrenergic, dopaminergic, and serotonergic systems.

  12. Rigidity Emerges during Antibody Evolution in Three Distinct Antibody Systems: Evidence from QSFR Analysis of Fab Fragments.

    Science.gov (United States)

    Li, Tong; Tracka, Malgorzata B; Uddin, Shahid; Casas-Finet, Jose; Jacobs, Donald J; Livesay, Dennis R

    2015-07-01

    The effects of somatic mutations that transform polyspecific germline (GL) antibodies to affinity mature (AM) antibodies with monospecificity are compared among three GL-AM Fab pairs. In particular, changes in conformational flexibility are assessed using a Distance Constraint Model (DCM). We have previously established that the DCM can be robustly applied across a series of antibody fragments (VL to Fab), and subsequently, the DCM was combined with molecular dynamics (MD) simulations to similarly characterize five thermostabilizing scFv mutants. The DCM is an ensemble based statistical mechanical approach that accounts for enthalpy/entropy compensation due to network rigidity, which has been quite successful in elucidating conformational flexibility and Quantitative Stability/Flexibility Relationships (QSFR) in proteins. Applied to three disparate antibody systems changes in QSFR quantities indicate that the VH domain is typically rigidified, whereas the VL domain and CDR L2 loop become more flexible during affinity maturation. The increase in CDR H3 loop rigidity is consistent with other studies in the literature. The redistribution of conformational flexibility is largely controlled by nonspecific changes in the H-bond network, although certain Arg to Asp salt bridges create highly localized rigidity increases. Taken together, these results reveal an intricate flexibility/rigidity response that accompanies affinity maturation.

  13. Gas Absorption in the KH 15D System: Further Evidence for Dust Settling in the Circumbinary Disk

    CERN Document Server

    Lawler, S M; Redfield, S; Hamilton, C M; Johns-Krull, C M; Winn, J N; Johnson, J A; Mundt, R

    2010-01-01

    Na I D lines in the spectrum of the young binary KH 15D have been analyzed in detail. We find an excess absorption component that may be attributed to foreground interstellar absorption, and to gas possibly associated with the solids in the circumbinary disk. The derived column density is log N_NaI = 12.5 cm^-2, centered on a radial velocity that is consistent with the systemic velocity. Subtracting the likely contribution of the ISM leaves log N_NaI ~ 12.3 cm^-2. There is no detectable change in the gas column density across the "knife edge" formed by the opaque grain disk, indicating that the gas and solids have very different scale heights, with the solids being highly settled. Our data support a picture of this circumbinary disk as being composed of a very thin particulate grain layer composed of millimeter-sized or larger objects that are settled within whatever remaining gas may be present. This phase of disk evolution has been hypothesized to exist as a prelude to the formation of planetesimals through...

  14. Evidence of limited carbon sequestration in soils under no-tillage systems in the Cerrado of Brazil.

    Science.gov (United States)

    Corbeels, Marc; Marchão, Robelio Leandro; Neto, Marcos Siqueira; Ferreira, Eliann Garcia; Madari, Beata Emöke; Scopel, Eric; Brito, Osmar Rodrigues

    2016-02-24

    The Brazilian government aims at augmenting the area cropped under no-tillage (NT) from 32 to 40 million ha by 2020 as a means to mitigate CO2 emissions. We estimated soil carbon (C) sequestration under continuous NT systems in two municipalities in the Goiás state that are representative of the Cerrado. A chronosequence of NT fields of different age since conversion from conventional tillage (CT) was sampled in 2003 and 2011. Soil C levels of native Cerrado and pasture were measured for comparison. After about 11 to 14 years, soil C stocks under NT were highest and at the levels of those under natural Cerrado. Average annual rates of soil C sequestration estimated using the chronosequence approach were respectively 1.61 and 1.48 Mg C ha(-1) yr(-1) for the 2003 and 2011 sampling, and were higher than those observed using repeated sampling after eight years. The diachronic sampling revealed that the younger NT fields tended to show higher increases in soil C stocks than the older fields. Converting an extra 8 million ha of cropland from CT to NT represents an estimated soil C storage of about 8 Tg C yr(-1) during 10 to 15 years.

  15. Utility of Boston Qualitative Scoring System for Rey-Osterrieth Complex Figure: evidence from a Parkinson's Diseases sample.

    Science.gov (United States)

    Scarpina, Federica; Ambiel, Erika; Albani, Giovanni; Pradotto, Luca Guglielmo; Mauro, Alessandro

    2016-10-01

    This study examined the ability of the Boston Qualitative Scoring System (BQSS) in comparison to the Osterrieth scoring method to separate Parkinson's Disease patients without dementia from healthy controls at the Rey-Osterrieth Complex Figure (ROCF) copy. 30 PD participants and 30 healthy participants completed ROCF copy. The performance was scored according to both methods. The results indicated that PD patients performed significantly worse on ROCF. According to ROC analyses, BQSS Copy Total score represented the most suitable index to distinguish between the two groups: a score below or equal to 16 indicates an impaired performance. Moreover, PD participants reported lower performance in the BQSS scores of Planning and Neatness. PD patients' poor performance in ROCF copy was related to executive difficulties, specifically in terms of planning and impulsivity, instead of global visuo-constructional impairments. An extensive evaluation of copy drawings allowing to disentangle between different involved cognitive domains would be suitable, specifically in those clinical conditions like PD, in which motor impairments affect drawing performance.

  16. Do attitudes toward societal structure predict beliefs about free will and achievement? Evidence from the Indian caste system.

    Science.gov (United States)

    Srinivasan, Mahesh; Dunham, Yarrow; Hicks, Catherine M; Barner, David

    2016-01-01

    Intuitive theories about the malleability of intellectual ability affect our motivation and achievement in life. But how are such theories shaped by the culture in which an individual is raised? We addressed this question by exploring how Indian children's and adults' attitudes toward the Hindu caste system--and its deterministic worldview--are related to differences in their intuitive theories. Strikingly, we found that, beginning at least in middle school and continuing into adulthood, individuals who placed more importance on caste were more likely to adopt deterministic intuitive theories. We also found a developmental change in the scope of this relationship, such that in children, caste attitudes were linked only to abstract beliefs about personal freedom, but that by adulthood, caste attitudes were also linked to beliefs about the potential achievement of members of different castes, personal intellectual ability, and personality attributes. These results are the first to directly relate the societal structure in which a person is raised to the specific intuitive theories they adopt.

  17. Access to HIV community services by vulnerable populations: evidence from an enhanced HIV/AIDS surveillance system.

    Science.gov (United States)

    Madden, H C E; Phillips-Howard, P A; Hargreaves, S C; Downing, J; Bellis, M A; Vivancos, R; Morley, C; Syed, Q; Cook, P A

    2011-05-01

    HIV disproportionately affects vulnerable populations such as black and minority ethnic groups, men who have sex with men (MSM) and migrants, in many countries including those in the UK. Community organisations in the UK are charitable non-governmental organisations with a proportion of the workforce who volunteer, and provide invaluable additional support for people living with HIV (PLWHIV). Information on their contribution to HIV care in vulnerable groups is relatively sparse. Data generated from an enhanced HIV surveillance system in North West England, UK, was utilised for this study. We aimed to determine the characteristics of individuals who chose to access community services in addition to clinical services (1375 out of 4195 records of PLWHIV in clinical services). Demographic information, risk factors including residency status, uniquely gathered in this region, and deprivation scores were examined. Multivariate logistic regression modelling was conducted to predict the relative effect of patient characteristics on attendance at community services. Attendance at community services was highest in those living in the most, compared with least, deprived areas (prefugees (AOR = 5.75, 95% CI 3.3-10.03; pmigrant workers (AOR = 5.48, 95% CI 2.22-13.51; pmigrant populations, community services are vital for the management of HIV in black and minority groups. Paradoxically, this coincides with increasing funding pressures on these services.

  18. 当前电信诈骗犯罪证据体系构建研究%Research on Current Telecom Fraud Crime Evidence System Construction

    Institute of Scientific and Technical Information of China (English)

    史亚杰

    2015-01-01

    近年来,随着社会经济、信息技术的发展,电信诈骗犯罪作为一种新型诈骗犯罪形式手法不断翻新,涉案金额逐年递升。尽管有关部门对电信诈骗犯罪给予了高度重视,采取了各种防控措施,但是并没有取得很好的效果。电信诈骗犯罪取证难、证据体系脆弱已经成为电信诈骗犯罪打击难的主要原因。因此,电信诈骗犯罪证据体系的构建成为我国打击该类犯罪亟需解决的重要课题。%In recent years, with the development of social economy, information technology, telecom fraud technique as a new form of crime of fraud, involving the amount is increasing year by year. Although the relevant departments of the telecom fraud has given a high degree of attention, taking a variety of prevention and control measures, but did not get good result. It is hard to get telecom fraud crime evidence and weak evidence system has become the main reason for the difficulty of telecom fraud crime.

  19. Comparative proteomic analysis of serum from patients with systemic sclerosis and sclerodermatous GVHD. Evidence of defective function of factor H.

    Directory of Open Access Journals (Sweden)

    Cinzia Scambi

    Full Text Available BACKGROUND: Systemic sclerosis (SSc is an autoimmune disease characterized by immunological and vascular abnormalities. Until now, the cause of SSc remains unclear. Sclerodermatous graft-versus-host disease (ScGVHD is one of the most severe complications following bone marrow transplantation (BMT for haematological disorders. Since the first cases, the similarity of ScGVHD to SSc has been reported. However, both diseases could have different etiopathogeneses. The objective of this study was to identify new serum biomarkers involved in SSc and ScGVHD. METHODOLOGY: Serum was obtained from patients with SSc and ScGVHD, patients without ScGVHD who received BMT for haematological disorders and healthy controls. Bi-dimensional electrophoresis (2D was carried out to generate maps of serum proteins from patients and controls. The 2D maps underwent image analysis and differently expressed proteins were identified. Immuno-blot analysis and ELISA assay were used to validate the proteomic data. Hemolytic assay with sheep erythrocytes was performed to evaluate the capacity of Factor H (FH to control complement activation on the cellular surface. FH binding to endothelial cells (ECs was also analysed in order to assess possible dysfunctions of this protein. PRINCIPAL FINDINGS: Fourteen differentially expressed proteins were identified. We detected pneumococcal antibody cross-reacting with double stranded DNA in serum of all bone marrow transplanted patients with ScGVHD. We documented higher levels of FH in serum of SSc and ScGVHD patients compared healthy controls and increased sheep erythrocytes lysis after incubation with serum of diffuse SSc patients. In addition, we observed that FH binding to ECs was reduced when we used serum from these patients. CONCLUSIONS: The comparative proteomic analysis of serum from SSc and ScGVHD patients highlighted proteins involved in either promoting or maintaining an inflammatory state. We also found a defective function

  20. Muscle activation during maximal effort tasks: evidence of the selective forces that shaped the musculoskeletal system of humans

    Directory of Open Access Journals (Sweden)

    David R. Carrier

    2015-12-01

    Full Text Available The selective forces that played a role in the evolution of the musculoskeletal system of the genus Homo have long been debated and remain poorly understood. In this investigation, we introduce a new approach for testing alternative hypotheses. Our analysis is based on the premise that natural selection can be expected to have resulted in muscles that are large enough to achieve necessary levels of maximum performance in essential behaviors, but not larger. We used surface electromyography in male subjects to identify maximum activation levels in 13 muscles of the back and leg during eight behaviors that have been suggested to have been important to foraging, hunting and fighting performance in early humans. We asked two questions: (1 what behaviors produce maximum activation in each of the investigated muscles and (2 are there specific behaviors that elicit maximum recruitment from all or most of the muscles? We found that in eight of the 13 muscles, the highest activity occurred during maximal effort vertical jumping (i.e. whole-body acceleration. Punching produced the highest median activity in the other five muscles. Together, jumping and punching accounted for 73% of the incidences of maximum activity among all of the muscles and from all of the subjects. Thus, the size of the muscles of the back and leg appear to be more related to the demands of explosive behaviors rather than those of high speed sprinting or sustained endurance running. These results are consistent with the hypothesis that selection on aggressive behavior played an important role in the evolution of the genus Homo.

  1. Secondary foundation species as drivers of trophic and functional diversity: evidence from a tree-epiphyte system.

    Science.gov (United States)

    Angelini, Christine; Silliman, Brian R

    2014-01-01

    Facilitation cascades arise where primary foundation species facilitate secondary (dependent) foundation species, and collectively, they increase habitat complexity and quality to enhance biodiversity. Whether such phenomena occur in nonmarine systems and if secondary foundation species enhance food web structure (e.g., support novel feeding guilds) and ecosystem function (e.g., provide nursery for juveniles) remain unclear. Here we report on field experiments designed to test whether trees improve epiphyte survival and epiphytes secondarily increase the number and diversity of adult and juvenile invertebrates in a potential live oak-Tillandsia usneoides (Spanish moss) facilitation cascade. Our results reveal that trees reduce physical stress to facilitate Tillandsia, which, in turn, reduces desiccation and predation stress to facilitate invertebrates. In experimental removals, invertebrate total density, juvenile density, species richness and H' diversity were 16, 60, 1.7, and 1.5 times higher, and feeding guild richness and H' were 5 and 11 times greater in Tillandsia-colonized relative to Tillandsia-removal limb plots. Tillandsia enhanced communities similarly in a survey across the southeastern United States. These findings reveal that a facilitation cascade organizes this widespread terrestrial assemblage and expand the role of secondary foundation species as drivers of trophic structure and ecosystem function. We conceptualize the relationship between foundation species' structural attributes and associated species abundance and composition in a Foundation Species-Biodiversity (FSB) model. Importantly, the FSB predicts that, where secondary foundation species form expansive and functionally distinct structures that increase habitat availability and complexity within primary foundation species, they generate and maintain hot spots of biodiversity and trophic interactions.

  2. Muscle activation during maximal effort tasks: evidence of the selective forces that shaped the musculoskeletal system of humans.

    Science.gov (United States)

    Carrier, David R; Schilling, Nadja; Anders, Christoph

    2015-11-04

    The selective forces that played a role in the evolution of the musculoskeletal system of the genus Homo have long been debated and remain poorly understood. In this investigation, we introduce a new approach for testing alternative hypotheses. Our analysis is based on the premise that natural selection can be expected to have resulted in muscles that are large enough to achieve necessary levels of maximum performance in essential behaviors, but not larger. We used surface electromyography in male subjects to identify maximum activation levels in 13 muscles of the back and leg during eight behaviors that have been suggested to have been important to foraging, hunting and fighting performance in early humans. We asked two questions: (1) what behaviors produce maximum activation in each of the investigated muscles and (2) are there specific behaviors that elicit maximum recruitment from all or most of the muscles? We found that in eight of the 13 muscles, the highest activity occurred during maximal effort vertical jumping (i.e. whole-body acceleration). Punching produced the highest median activity in the other five muscles. Together, jumping and punching accounted for 73% of the incidences of maximum activity among all of the muscles and from all of the subjects. Thus, the size of the muscles of the back and leg appear to be more related to the demands of explosive behaviors rather than those of high speed sprinting or sustained endurance running. These results are consistent with the hypothesis that selection on aggressive behavior played an important role in the evolution of the genus Homo.

  3. Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of garlic extract in mice

    Directory of Open Access Journals (Sweden)

    Dhingra Dinesh

    2008-01-01

    Full Text Available Objectives: The present study was undertaken to investigate the effect of the ethanolic extract of Allium sativum L. (Family: Lilliaceae, commonly known as garlic, on depression in mice. Materials and Methods: Ethanolic extract of garlic (25, 50 and 100 mg/kg was administered orally for 14 successive days to young Swiss albino mice of either sex and antidepressant-like activity was evaluated employing tail suspension test (TST and forced swim test (FST. The efficacy of the extract was compared with standard antidepressant drugs like fluoxetine and imipramine. The mechanism of action of the extract was investigated by co-administration of prazosin (α1-adrenoceptor antagonist, sulpiride (selective D2-receptor antagonist, baclofen (GABA B agonist and p-CPA (serotonin antagonist separately with the extract and by studying the effect of the extract on brain MAO-A and MAO-B levels. Results: Garlic extract (25, 50 and 100 mg/kg significantly decreased immobility time in a dose-dependent manner in both TST and FST, indicating significant antidepressant-like activity. The efficacy of the extract was found to be comparable to fluoxetine (20 mg/kg p.o. and imipramine (15 mg/kg p.o. in both TST and FST. The extract did not show any significant effect on the locomotor activity of the mice. Prazosin, sulpiride, baclofen and p-CPA significantly attenuated the extract-induced antidepressant-like effect in TST. Garlic extract (100 mg/kg administered orally for 14 successive days significantly decreased brain MAO-A and MAO-B levels, as compared to the control group. Conclusion: Garlic extract showed significant antidepressant-like activity probably by inhibiting MAO-A and MAO-B levels and through interaction with adrenergic, dopaminergic, serotonergic and GABAergic systems.

  4. Improving the Flash Flood Frequency Analysis using dendrogeomorphological evidences in the Arenal River crossing Arenas de San Pedro Village (Spanish Central System)

    Science.gov (United States)

    Ruiz-Villanueva, V.; Ballesteros, J. A.; Díez-Herrero, A.; Bodoque, J. M.

    2009-04-01

    The flash flood frequency analysis in mountainous catchments presents specific scientific challenges. One of the challenges is the relevant gradient in precipitation intensity with altitude. Another challenge is the lack of information from rainfall or discharge gauge stations or from documentary sources. Dendrogeomorphology studies the response in the wood growth pattern and the botanical signs on the trees affected by geomorphological processes. With regard to the flood frequency, the dendrogeomorphological evidences bring forward valuable infomation about single past events (with annual or even seasonal precision) and their occurrence periodicity. The main macro-evidence that we can find in the tree trunk is a stem scar originated by a wound in the bark of the tree. When the tree grows, this wound remains reflected in the tree ring sequence. The best way to analyze the tree ring sequence is by using a complete section of the trunk, this couldn't be possible unless the tree is cut down. Due to the unfeasibility of cutting down the trees, in Dendrogeomorphology is enough to obtain an increment core, using a Pressler borer. Nevertheless, this study has been based on complete stem sections analysis facilitated for the felling works in the riverine vegetation in the Arenal River, carried out by the Tagus River Water Authority. These felling works have allowed us to obtain sections and to analyze the stump of the tree in situ. On this way, 100 samples of Alnus glutinosa and Fraxinus angustifolia located by the river along the Arenal River crossing Arenas de San Pedro Village (Ávila, northern slopes of the Gredos Mountain Range in the Spanish Central System) have been analyzed. This village is known for its historical problems of flood during extreme events. A meticulous fieldwork has been carried out. Every sample was analyzed locating its geomorphological position, the distance to the riverbed and the height of the stump in which the evidences were observed. Using a

  5. Evidence that the circadian system mediates photoperiodic nonresponsiveness in Siberian hamsters: the effect of running wheel access on photoperiodic responsiveness.

    Science.gov (United States)

    Freeman, D A; Goldman, B D

    1997-04-01

    role for locomotor activity feedback in modulating the circadian system and, subsequently, photoperiodic responsiveness in PNRj hamsters.

  6. Identification, mapping, and analysis of possible evidences of active petroleum systems in the Colorado Basin, offshore Argentina, South America

    Science.gov (United States)

    Loegering, Markus; Anka, Zahie; Rodriguez, Jorge; Marchal, Denis; di Primio, Rolando; Vallejo, Eduardo; Kohler, Guillermina; Pangaro, Francisco

    2010-05-01

    analysed in relation to structural and stratigraphic elements present within the syn-rift and post-rift successions. The main observed features consist of seismic vertical pipes where the seismic signal is strongly disturbed. The diameter of mapped seismic pipes ranges from 100 m up to 2000 m. Preliminary classification of these features shows two families of seismic pipes: (1) the first and principal family is mostly concentrated in the centre and innermost part of the basin and seems to be mainly controlled by the stratigraphy, ending in the Elvira Fm (Eocene). Many of these features are linked to the presence of volcanics, as demonstrated by some wells; (2) the second family is located on the oceanward outer part of the basin, reaching the seafloor and resulting in pockmark depressions or seabed mounds. These features represent possible candidates for gas chimneis. Other kinds of gas escape structures as seismic wipe-out zones and hydraulic brecciation are also tentatively observed. The present-day bathymetry from 3D seismic reflection data indicates the presence of seabed pockmarks and submarine channels on the slope of the basin. The circular to near-circular seafloor depressions initially identified on the 2D seismic-reflection profiles correspond to circular-to-elongate pockmarks mapped on the high-resolution bathymetry. Most of the pockmarks present a diameter from 200 m to 900 m and vertical length between 20 m to 100 m, and occur close to submarine channels, which range from 1000 m to 5000 m in width and from 100 m to 500 m in depth. A highly-dense vertically-faulted interval has been identified within the Colorado (Campanian) and Pedro Luro (Paleocene) Formations in the slope region of the basin. These faults correspond to polygonal fault systems that could breach Paleocene/Eocene sealing sequences, allowing fluids to flow vertically or sub-vertically across the seal. Numerical modelling of hydrocarbon generation and migration, calibrated to the observations on

  7. Evidence of the presence of a functional Dot/Icm type IV-B secretion system in the fish bacterial pathogen Piscirickettsia salmonis.

    Directory of Open Access Journals (Sweden)

    Fernando A Gómez

    Full Text Available Piscirickettsia salmonis is a fish bacterial pathogen that has severely challenged the sustainability of the Chilean salmon industry since its appearance in 1989. As this Gram-negative bacterium has been poorly characterized, relevant aspects of its life cycle, virulence and pathogenesis must be identified in order to properly design prophylactic procedures. This report provides evidence of the functional presence in P. salmonis of four genes homologous to those described for Dot/Icm Type IV Secretion Systems. The Dot/Icm System, the major virulence mechanism of phylogenetically related pathogens Legionella pneumophila and Coxiella burnetii, is responsible for their intracellular survival and multiplication, conditions that may also apply to P. salmonis. Our results demonstrate that the four P. salmonis dot/icm homologues (dotB, dotA, icmK and icmE are expressed both during in vitro tissue culture cells infection and growing in cell-free media, suggestive of their putative constitutive expression. Additionally, as it happens in other referential bacterial systems, temporal acidification of cell-free media results in over expression of all four P. salmonis genes, a well-known strategy by which SSTIV-containing bacteria inhibit phagosome-lysosome fusion to survive. These findings are very important to understand the virulence mechanisms of P. salmonis in order to design new prophylactic alternatives to control the disease.

  8. Spatio-temporal expression patterns of anandamide-binding receptors in rat implantation sites: evidence for a role of the endocannabinoid system during the period of placental development

    Directory of Open Access Journals (Sweden)

    Konje Justin C

    2009-10-01

    Full Text Available Abstract Background Although there is growing evidence that endocannabinoids play a critical role in early pregnancy, there are no studies describing the possible targets for this system after implantation. The endometrial stroma, which undergoes extensive proliferation and differentiation giving rise to the decidua and the trophoblast cells that invade after the initial stages of implantation, are potential targets. Since high anandamide (AEA levels, the main endocannabinoid, are detrimental to implantation and in order to gain insight into the role of the endocannabinoid system in the development of the fetoplacental unit, the spatio-temporal pattern of expression of the anandamide-binding receptors, CB1, CB2 and the vanilloid receptor (TRPV1, were investigated by quantitative RT-PCR, western blot and immunohistochemistry. Methods Rat uterine maternal tissues from different days of pregnancy were used to investigate the expression of CB1, CB2 and vanilloid receptors by quantitative RT-PCR, western blot and immunohistochemistry. Results The data indicate that all the three receptors were expressed in decidualized cells and placenta. Interestingly, CB1 and CB2 were also expressed in smooth muscle cells of maternal blood vessels and in endovascular trophoblast cells, whereas TRPV1 was mainly expressed in uterine natural killer (uNK cells and in the longitudinal muscle layer throughout pregnancy. In all tissues, CB2 protein was present at a lower level than CB1. Conclusion These observations support a role for the endocannabinoid system during the period of decidualization and placental development.

  9. Vaccination in paediatric patients with auto-immune rheumatic diseases : A systemic literature review for the European League against Rheumatism evidence-based recommendations

    NARCIS (Netherlands)

    Heijstek, M. W.; de Bruin, L. M. Ott; Borrow, R.; van der Klis, F.; Kone-Paut, I.; Fasth, A.; Minden, K.; Ravelli, A.; Abinun, M.; Pileggi, G.; Borte, M.; Bijl, M.; Wulffraat, N. M.

    2011-01-01

    Objectives: To analyze available evidence on vaccinations in paediatric patients with rheumatic and auto-inflammatory diseases. This evidence formed the basis of the recently constructed European League against Rheumatism (EULAR) recommendations for vaccination of these patients. Methods: A systemat

  10. Isotopic evidence for the infiltration of mantle and metamorphic CO2-H2O fluids from below in faulted rocks from the San Andreas Fault System

    Energy Technology Data Exchange (ETDEWEB)

    Pili, E.; Kennedy, B.M.; Conrad, M.E.; Gratier, J.-P.

    2010-12-15

    To characterize the origin of the fluids involved in the San Andreas Fault (SAF) system, we carried out an isotope study of exhumed faulted rocks from deformation zones, vein fillings and their hosts and the fluid inclusions associated with these materials. Samples were collected from segments along the SAF system selected to provide a depth profile from upper to lower crust. In all, 75 samples from various structures and lithologies from 13 localities were analyzed for noble gas, carbon, and oxygen isotope compositions. Fluid inclusions exhibit helium isotope ratios ({sup 3}He/{sup 4}He) of 0.1-2.5 times the ratio in air, indicating that past fluids percolating through the SAF system contained mantle helium contributions of at least 35%, similar to what has been measured in present-day ground waters associated with the fault (Kennedy et al., 1997). Calcite is the predominant vein mineral and is a common accessory mineral in deformation zones. A systematic variation of C- and O-isotope compositions of carbonates from veins, deformation zones and their hosts suggests percolation by external fluids of similar compositions and origin with the amount of fluid infiltration increasing from host rocks to vein to deformation zones. The isotopic trend observed for carbonates in veins and deformation zones follows that shown by carbonates in host limestones, marbles, and other host rocks, increasing with increasing contribution of deep metamorphic crustal volatiles. At each crustal level, the composition of the infiltrating fluids is thus buffered by deeper metamorphic sources. A negative correlation between calcite {delta}{sup 13}C and fluid inclusion {sup 3}He/{sup 4}He is consistent with a mantle origin for a fraction of the infiltrating CO{sub 2}. Noble gas and stable isotope systematics show consistent evidence for the involvement of mantle-derived fluids combined with infiltration of deep metamorphic H{sub 2}O and CO{sub 2} in faulting, supporting the involvement of

  11. 破坏计算机信息系统罪的证据研究%Research on the Evidence of the Crime of Destroying Computer Information Systems

    Institute of Scientific and Technical Information of China (English)

    陈荔

    2013-01-01

    随着信息科技的迅速发展,人们对于计算机及网络虚拟生活的依赖程度日益提高,破坏计算机信息系统类犯罪也越来越多,文章从上海检察机关相关案例入手,从电子数据的收集鉴定和审查认定方面探讨破坏计算机信息系统案件类案件在理论和实务中遇到的问题。%With the rapid development of information technology, people's dependence on computer and network virtual life is increasing. The Crime of Destroying Computer Information Systems is also increasing. This article starts from Shanghai prosecution’s case, encountered in both theory and practice problems with forensic and examination of electronic evidence collected from the crime of destroying computer information systems.

  12. The what, when, and why of implementation frameworks for evidence-based practices in child welfare and child mental health service systems.

    Science.gov (United States)

    Hanson, Rochelle F; Self-Brown, Shannon; Rostad, Whitney L; Jackson, Matthew C

    2016-03-01

    It is widely recognized that children in the child welfare system are particularly vulnerable to the adverse health and mental effects associated with exposure to abuse and neglect, making it imperative to have broad-based availability of evidence-based practices (EBPs) that can prevent child maltreatment and reduce the negative mental health outcomes for youth who are victims. A variety of EBPs exist for reducing child maltreatment risk and addressing the associated negative mental health outcomes, but the reach of these practices is limited. An emerging literature documents factors that can enhance or inhibit the success of EBP implementation in community service agencies, including how the selection of a theory-driven conceptual framework, or model, might facilitate implementation planning by providing guidance for best practices during implementation phases. However, limited research is available to guide decision makers in the selection of implementation frameworks that can boost implementation success for EBPs that focus on preventing child welfare recidivism and serving the mental health needs of maltreated youth. The aims of this conceptual paper are to (1) provide an overview of existing implementation frameworks, beginning with a discussion of definitional issues and the selection criteria for frameworks included in the review; and (2) offer recommendations for practice and policy as applicable for professionals and systems serving victims of child maltreatment and their families.

  13. First evidence of "paralytic shellfish toxins" and cylindrospermopsin in a Mexican freshwater system, Lago Catemaco, and apparent bioaccumulation of the toxins in "tegogolo" snails (Pomacea patula catemacensis).

    Science.gov (United States)

    Berry, John P; Lind, Owen

    2010-05-01

    Exposure to cyanobacterial toxins in freshwater systems, including both direct (e.g., drinking water) and indirect (e.g., bioaccumulation in food webs) routes, is emerging as a potentially significant threat to human health. We investigated cyanobacterial toxins, specifically cylindrospermopsin (CYN), the microcystins (MCYST) and the "paralytic shellfish toxins" (PST), in Lago Catemaco (Veracruz, Mexico). Lago Catemaco is a tropical lake dominated by Cylindrospermopsis, specifically identified as Cylindrospermopsis catemaco and Cylindrospermopsis philippinensis, and characterized by an abundant, endemic species of snail (Pomacea patula catemacensis), known as "tegogolos," that is both consumed locally and commercially important. Samples of water, including dissolved and particulate fractions, as well as extracts of tegogolos, were screened using highly specific and sensitive ELISA. ELISA identified CYN and PST at low concentrations in only one sample of seston; however, both toxins were detected at appreciable quantities in tegogolos. Calculated bioaccumulation factors (BAF) support bioaccumulation of both toxins in tegogolos. The presence of CYN in the phytoplankton was further confirmed by HPLC-UV and LC-MS, following concentration and extraction of algal cells, but the toxin could not be confirmed by these methods in tegogolos. These data represent the first published evidence for CYN and the PST in Lago Catemaco and, indeed, for any freshwater system in Mexico. Identification of the apparent bioaccumulation of these toxins in tegogolos may suggest the need to further our understanding of the transfer of cyanobacterial toxins in freshwater food webs as it relates to human health.

  14. Evidence-based development and first usability testing of a social serious game based multi-modal system for early screening for atypical socio-cognitive development.

    Science.gov (United States)

    Gyori, Miklos; Borsos, Zsófia; Stefanik, Krisztina

    2015-01-01

    At current, screening for, and diagnosis of, autism spectrum disorders (ASD) are based on purely behavioral data; established screening tools rely on human observation and ratings of relevant behaviors. The research and development project in the focus of this paper is aimed at designing, creating and evaluating a social serious game based multi-modal, interactive software system for screening for high functioning cases of ASD at kindergarten age. The aims of this paper are (1) to summarize the evidence-based design process and (2) to present results from the first usability test of the system. Game topic, candidate responses, and candidate game contents were identified via an iterative literature review. On this basis, the 1st partial prototype of the fully playable game has been created, with complete data recording functionality but without the decision making component. A first usability test was carried out on this prototype (n=13). Overall results were unambiguously promising. Although sporadic difficulties in, and slightly negative attitudes towards, using the game occasionally arose, these were confined to non-target-group children only. The next steps of development include (1) completing the game design; (2) carrying out first large-n field test; (3) creating the first prototype of the decision making component.

  15. LTDNA Evidence on Trial

    Science.gov (United States)

    Roberts, Paul

    2016-01-01

    Adopting the interpretative/hermeneutical method typical of much legal scholarship, this article considers two sets of issues pertaining to LTDNA profiles as evidence in criminal proceedings. The section titled Expert Evidence as Forensic Epistemic Warrant addresses some rather large questions about the epistemic status and probative value of expert testimony in general. It sketches a theoretical model of expert evidence, highlighting five essential criteria: (1) expert competence; (2) disciplinary domain; (3) methodological validity; (4) materiality; and (5) legal admissibility. This generic model of expert authority, highlighting law's fundamentally normative character, applies to all modern forms of criminal adjudication, across Europe and farther afield. The section titled LTDNA Evidence in UK Criminal Trials then examines English and Northern Irish courts' attempts to get to grips with LTDNA evidence in recent cases. Better appreciating the ways in which UK courts have addressed the challenges of LTDNA evidence may offer some insights into parallel developments in other legal systems. Appellate court rulings follow a predictable judicial logic, which might usefully be studied and reflected upon by any forensic scientist or statistician seeking to operate effectively in criminal proceedings. Whilst each legal jurisdiction has its own unique blend of jurisprudence, institutions, cultures and historical traditions, there is considerable scope for comparative analysis and cross-jurisdictional borrowing and instruction. In the spirit of promoting more nuanced and sophisticated international interdisciplinary dialogue, this article examines UK judicial approaches to LTDNA evidence and begins to elucidate their underlying institutional logic. Legal argument and broader policy debates are not confined to considerations of scientific validity, contamination risks and evidential integrity, or associated judgments of legal admissibility or exclusion. They also crucially

  16. Biodegradable beta-Tri-Calciumphosphate/hydroxyethyl methacrylate enhanced three component bone adhesive demonstrates biocompatibility without evidence of systemic toxicity in a rabbit model.

    Science.gov (United States)

    Bauer, Natali B; Brinke, Nina; Heiss, Christian; Skorupa, Agnes B; Peters, Fabian; Kraus, Ralf; Schnettler, Reinhard; Moritz, Andreas

    2009-08-01

    Bone gluing is an attractive surgical technique; however, its use in patients is hampered by a variety of side effects. Therefore, it was the aim of this ethically approved study to evaluate a novel biodegradable beta-Tri-Calciumphosphate (beta-TCP, Cerasorb)-enhanced bone adhesive regarding its toxicity and biocompatibility in a rabbit model. Fifty healthy New Zealand White rabbits were assigned in the study (n = 21) and sham-operated control group (n = 29). In the study group, a cylindrical part (4.6 x 10.0 mm) of the proximal tibia and distal femur was removed, reimplanted, and bone adhesive was applied. Blinded physical examination and sampling for hematology, clinical chemistry, and acute phase proteins (haptoglobin, C-reactive protein (CRP)) was performed before surgery and after 12, 24, 48, 72, 240, and 504 h. Significant findings of the physical examination included a slightly higher grading of warmth (p = 0.0019) and pain (p < 0.0001) of the wound 240 h after surgery in the study group. No significant differences between albumin, haptoglobin, CRP, and urea concentrations in both groups were evident, whereas the study group demonstrated significantly lower leukocyte count, total protein, and globulin concentrations (p < 0.0001). As expected, both groups showed a marked transient increase in muscle enzymes (Creatine Kinase and Aspartate Aminotransferase) following the surgery (p < 0.0001). Twelve to 24 h after surgery, a significant decrease in ionized calcium from 1.38 +/- 0.12 mmol/L to 1.06 +/- 0.13 mmol/L was noted in the study group (p < 0.0001). The results clearly indicated that the novel beta-TCP-enhanced bone adhesive showed good biocompatibility without significant evidence of acute or subacute local or systemic toxicity.

  17. Limits of Evidence within EU

    Directory of Open Access Journals (Sweden)

    Monica Pocora

    2015-05-01

    Full Text Available The issue of admissibility of evidence has been regulated only very scarcely in the EU. Judicial cooperation in criminal matters has been embracing the increasing number of instruments, covering plethora of aspects, however, the field of admissibility of evidence remains almost untouched. Can the Area of Freedom, Security and Justice be called the Common Evidence Area? From the national perspective, the issue of admissibility of evidence is still subject to divergent solutions in the Member States, concerning the common law and continental law systems, i.e. the right of access to a lawyer. Thus, the paper aims to take into account the tendencies of legal rule in matter of admissibility of evidence, the dynamic of evidence movement within EU area.

  18. Coming to grips with negative evidence for the Comprehensive System for the Rorschach: a comment on Gacono, Loving, and Bodholdt; Ganellen; and Bornstein.

    Science.gov (United States)

    Wood, J M; Lilienfeld, S O; Nezworski, M T; Garb, H N

    2001-08-01

    The Comprehensive System (CS; Exner, 1991, 1993) for the Rorschach is currently engulfed in controversy. This comment article responds to 3 articles by Rorschach proponents in this issue of the Journal of Personality Assessment. Contrary to the claims of Gacono, Loving, and Bodholdt (this issue), CS scores do not bear a well-demonstrated relationship to psychopathy, antisocial personality disorder, or conduct disorder. Contrary to the claims of Ganellen (this issue), both the original and the revised CS Depression Index (Exner, 1993) bear little or no relationship to depression diagnoses. Furthermore, the scoring reliability of some CS scores is problematic. Although we agree with Bornstein (this issue) that Rorschach scores generally bear little or no relation to psychiatric diagnoses or self-report questionnaires, we believe this lack of relationship tends to disconfirm hypotheses concerning the validity of the Rorschach. In the spirit of the philosopher Sir Karl Popper, the Rorschach community should not minimize negative evidence or engage in post hoc arguments to immunize the CS against falsification.

  19. 电子数据证据收集系统的研究与保护%Research and Protection of the Digital Evidence Collecting System

    Institute of Scientific and Technical Information of China (English)

    孙波; 孙玉芳

    2005-01-01

    随着计算机犯罪的不断增加,电子数据取证技术(digital forensic technology)越来越受到人们的重视.电子数据证据不同于传统的犯罪证据,它们更加容易消失和被破坏,为了获得完整可信的电子数据证据,提出应在敏感主机中预先安装设置电子数据证据收集系统(digital evidence collecting system,DECS),用来收集系统中的相关证据.由于DECS的某些模块往往存在于被攻击系统之中,提出使用安全隔离环境是保护电子数据证据收集机制有效的方法,并设计了一个安全保护机制--I-LOMAC.

  20. The first quantitative rating system of the antioxidant capacity of beauty creams via the Briggs-Rauscher reaction: a crucial step towards evidence-based cosmetics.

    Science.gov (United States)

    Cecchi, Teresa; Cecchi, Patrizio; Passamonti, Paolo

    2011-02-07

    Oxidative damage is the primary cause of skin aging. Skin care products are numerous and overwhelming, yet there is certain similarity among different formulations. Moisturizers are ubiquitous and the presence of particular added ingredients supports specific marketing claims. The antioxidant effects of botanical polyphenols possess tremendous marketing appeal, because oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) and the skin ability to neutralize them. The concept of evidence-based cosmetics lacks a widely accepted method to estimate the antioxidant capacity of the beauty cream. This was the motive force of the present study: for the first time we put forth a quantitative rating system of skin care products. The overall antioxidant power of 75 widely used and advertised beauty creams was comparatively measured via the oscillating Briggs-Rauscher (BR) reaction. Many dermocosmetic products confirmed their ability to ensure protection against free radicals, even if differences among various creams are striking and often not correlated with the their price. The method we developed is simple and cheap and it can allow dermatologists and consumers to compare and choose effectively; on the other hand, producers can used this method to select the most active antioxidant cosmetic agent to optimise the product performance.

  1. Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system.

    Science.gov (United States)

    Borroto-Escuela, Dasiel O; Narvaez, Manuel; Pérez-Alea, Mileidys; Tarakanov, Alexander O; Jiménez-Beristain, Antonio; Mudó, Giuseppa; Agnati, Luigi F; Ciruela, Francisco; Belluardo, Natale; Fuxe, Kjell

    2015-01-02

    The ascending midbrain 5-HT neurons known to contain 5-HT1A autoreceptors may be dysregulated in depression due to a reduced trophic support. With in situ proximity ligation assay (PLA) and supported by co-location of the FGFR1 and 5-HT1A immunoreactivities in midbrain raphe 5-HT cells, evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes were obtained in the dorsal and median raphe nuclei of the Sprague-Dawley rat. Their existence in the rat medullary raphe RN33B cell cultures was also established. After combined FGF-2 and 8-OH-DPAT treatment, a marked and significant increase in PLA positive clusters was found in the RN33B cells. Similar results were reached upon coactivation by agonists in HEK293T cells using the Fluorescent Resonance Energy Transfer (FRET) technique resulting in increased FRETmax and reduced FRET50 values. The heteroreceptor complex formation was dependent on TMV of the 5-HT1A receptor since it was blocked by incubation with TMV but not with TMII. Taken together, the 5-HT1A autoreceptors by being recruited into a FGFR1-5-HT1A heteroreceptor complex in the midbrain raphe 5-HT nerve cells may develop a novel function, namely a trophic role in many midbrain 5-HT neuron systems originating from the dorsal and medianus raphe nuclei.

  2. Natural Coronagraphic Observations of the Eclipsing T Tauri System KH 15D: Evidence for Accretion and Bipolar Outflow in a WTTS

    CERN Document Server

    Hamilton, C M; Mundt, R; Bailer-Jones, C A L; Johns-Krull, C M; Johns-Krull, Christopher M.

    2003-01-01

    We present high resolution (R $\\sim$ 44,000) UVES spectra of the eclipsing pre-main sequence star KH 15D covering the wavelength range 4780 to 6810 {\\AA} obtained at three phases: out of eclipse, near minimum light and during egress. The system evidently acts like a natural coronagraph, enhancing the contrast relative to the continuum of hydrogen and forbidden emission lines during eclipse. At maximum light the H$\\alpha$ equivalent width was $\\sim$2 {\\AA} and the profile showed broad wings and a deep central absorption. During egress the equivalent width was much higher ($\\sim$70 {\\AA}) and the broad wings, which extend to $\\pm$ 300 km/s, were prominent. During eclipse totality the equivalent width was less than during egress ($\\sim$40 {\\AA}) and the high velocity wings were much weaker. H$\\beta$ showed a somewhat different behavior, revealing only the blue-shifted portion of the high velocity component during eclipse and egress. [OI] $\\lambda\\lambda$6300, 6363 lines are easily seen both out of eclipse and wh...

  3. Healthy F-16 pilots show no evidence of exposure to tri-ortho-cresyl phosphate through the on-board oxygen generating system.

    Science.gov (United States)

    Tacal, Ozden; Schopfer, Lawrence M

    2014-05-25

    About 18% of fighter pilots complain of ill symptoms that begin during flight and persist for days. A possible source of toxicity is the air supplied through the on board oxygen generating system. The air passes through the jet engine before it is enriched for oxygen and breathed through an oxygen mask. While in the jet engine, the air can become contaminated with jet engine lubricating oil. A potentially toxic component in jet engine oil is tri-ortho-cresyl phosphate (TOCP), which is metabolically activated to the highly reactive cresyl saligenin phosphate. The cresyl saligenin phosphate reacts with butyrylcholinesterase (BChE) to make a covalent adduct on serine 198. The purpose of this work was to determine whether the blood of healthy, active-duty F-16 pilots has measurable levels of the cresyl phosphate adduct. BChE was immunopurified from 0.5ml plasma by binding to immobilized monoclonal mAb2. BChE protein was released with acetic acid, digested with pepsin and analyzed by LC-MS/MS on the 5600 Triple TOF mass spectrometer. Positive controls for quantifying the limit of detection were plasma samples containing known amounts of cresyl saligenin phosphate treated plasma. The cresyl phosphate adduct eluted at 31.3min with an observed parent ion mass of 966.4m/z and characteristic daughter ions 778.3, 673.3, and 602.3m/z. Control experiments demonstrated that as little as 0.1% of the 1-2μg BChE recovered from 0.5ml plasma could be detected as the cresyl phosphate adduct on peptide FGES198AGAAS. Mass spectrometry analysis of plasma from fifteen healthy F-16 pilots showed that none had evidence of exposure to TOCP. It was concluded that the on-board oxygen generating system, when operating properly, did not deliver tri-ortho-cresyl phosphate in the oxygen supply.

  4. Health system barriers to access and use of magnesium sulfate for women with severe pre-eclampsia and eclampsia in Pakistan: evidence for policy and practice.

    Science.gov (United States)

    Bigdeli, Maryam; Zafar, Shamsa; Assad, Hafeez; Ghaffar, Adbul

    2013-01-01

    Severe pre-eclampsia and eclampsia are rare but serious complications of pregnancy that threaten the lives of mothers during childbirth. Evidence supports the use of magnesium sulfate (MgSO4) as the first line treatment option for severe pre-eclampsia and eclampsia. Eclampsia is the third major cause of maternal mortality in Pakistan. As in many other Low- and Middle-Income Countries (LMIC), it is suspected that MgSO4 is critically under-utilized in the country. There is however a lack of information on context-specific health system barriers that prevent optimal use of this life-saving medicine in Pakistan. Combining quantitative and qualitative methods, namely policy document review, key informant interviews, focus group discussions and direct observation at health facility, we explored context-specific health system barriers and enablers that affect access and use of MgSO4 for severe pre-eclampsia and eclampsia in Pakistan. Our study finds that while international recommendations on MgSO4 have been adequately translated in national policies in Pakistan, the gap remains in implementation of national policies into practice. Barriers to access to and effective use of MgSO4 occur at health facility level where the medicine was not available and health staff was reluctant to use it. Low price of the medicine and the small market related to its narrow indications acted as disincentives for effective marketing. Results of our survey were further discussed in a multi-stakeholder round-table meeting and an action plan for increasing access to this life-saving medicine was identified.

  5. Deaths ascribed to non-communicable diseases among rural Kenyan adults are proportionately increasing: evidence from a health and demographic surveillance system, 2003-2010.

    Directory of Open Access Journals (Sweden)

    Penelope A Phillips-Howard

    Full Text Available Non-communicable diseases (NCDs result in more deaths globally than other causes. Monitoring systems require strengthening to attribute the NCD burden and deaths in low and middle-income countries (LMICs. Data from health and demographic surveillance systems (HDSS can contribute towards this goal.Between 2003 and 2010, 15,228 deaths in adults aged 15 years (y and older were identified retrospectively using the HDSS census and verbal autopsy in rural western Kenya, attributed into broad categories using InterVA-4 computer algorithms; 37% were ascribed to NCDs, 60% to communicable diseases (CDs, 3% to injuries, and <1% maternal causes. Median age at death for NCDs was 66y and 71y for females and males, respectively, with 43% (39% male, 48% female of NCD deaths occurring prematurely among adults aged below 65y. NCD deaths were mainly attributed to cancers (35% and cardio-vascular diseases (CVDs; 29%. The proportionate mortality from NCDs rose from 35% in 2003 to 45% in 2010 (χ2 linear trend 93.4; p<0.001. While overall annual mortality rates (MRs for NCDs fell, cancer-specific MRs rose from 200 to 262 per 100,000 population, mainly due to increasing deaths in adults aged 65y and older, and to respiratory neoplasms in all age groups. The substantial fall in CD MRs resulted in similar MRs for CDs and NCDs among all adult females by 2010. NCD MRs for adults aged 15y to <65y fell from 409 to 183 per 100,000 among females and from 517 to 283 per 100,000 population among males. NCD MRs were higher among males than females aged both below, and at or above, 65y.NCDs constitute a significant proportion of deaths in rural western Kenya. Evidence of the increasing contribution of NCDs to overall mortality supports international recommendations to introduce or enhance prevention, screening, diagnosis and treatment programmes in LMICs.

  6. Health system barriers to access and use of magnesium sulfate for women with severe pre-eclampsia and eclampsia in Pakistan: evidence for policy and practice.

    Directory of Open Access Journals (Sweden)

    Maryam Bigdeli

    Full Text Available Severe pre-eclampsia and eclampsia are rare but serious complications of pregnancy that threaten the lives of mothers during childbirth. Evidence supports the use of magnesium sulfate (MgSO4 as the first line treatment option for severe pre-eclampsia and eclampsia. Eclampsia is the third major cause of maternal mortality in Pakistan. As in many other Low- and Middle-Income Countries (LMIC, it is suspected that MgSO4 is critically under-utilized in the country. There is however a lack of information on context-specific health system barriers that prevent optimal use of this life-saving medicine in Pakistan. Combining quantitative and qualitative methods, namely policy document review, key informant interviews, focus group discussions and direct observation at health facility, we explored context-specific health system barriers and enablers that affect access and use of MgSO4 for severe pre-eclampsia and eclampsia in Pakistan. Our study finds that while international recommendations on MgSO4 have been adequately translated in national policies in Pakistan, the gap remains in implementation of national policies into practice. Barriers to access to and effective use of MgSO4 occur at health facility level where the medicine was not available and health staff was reluctant to use it. Low price of the medicine and the small market related to its narrow indications acted as disincentives for effective marketing. Results of our survey were further discussed in a multi-stakeholder round-table meeting and an action plan for increasing access to this life-saving medicine was identified.

  7. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.

    Directory of Open Access Journals (Sweden)

    Lisa F Barcellos

    2009-10-01

    Full Text Available A substantial genetic contribution to systemic lupus erythematosus (SLE risk is conferred by major histocompatibility complex (MHC gene(s on chromosome 6p21. Previous studies in SLE have lacked statistical power and genetic resolution to fully define MHC influences. We characterized 1,610 Caucasian SLE cases and 1,470 parents for 1,974 MHC SNPs, the highly polymorphic HLA-DRB1 locus, and a panel of ancestry informative markers. Single-marker analyses revealed strong signals for SNPs within several MHC regions, as well as with HLA-DRB1 (global p = 9.99 x 10(-16. The most strongly associated DRB1 alleles were: *0301 (odds ratio, OR = 2.21, p = 2.53 x 10(-12, *1401 (OR = 0.50, p = 0.0002, and *1501 (OR = 1.39, p = 0.0032. The MHC region SNP demonstrating the strongest evidence of association with SLE was rs3117103, with OR = 2.44 and p = 2.80 x 10(-13. Conditional haplotype and stepwise logistic regression analyses identified strong evidence for association between SLE and the extended class I, class I, class III, class II, and the extended class II MHC regions. Sequential removal of SLE-associated DRB1 haplotypes revealed independent effects due to variation within OR2H2 (extended class I, rs362521, p = 0.006, CREBL1 (class III, rs8283, p = 0.01, and DQB2 (class II, rs7769979, p = 0.003, and rs10947345, p = 0.0004. Further, conditional haplotype analyses demonstrated that variation within MICB (class I, rs3828903, p = 0.006 also contributes to SLE risk independent of HLA-DRB1*0301. Our results for the first time delineate with high resolution several MHC regions with independent contributions to SLE risk. We provide a list of candidate variants based on biologic and functional considerations that may be causally related to SLE risk and warrant further investigation.

  8. Geochemical characterization of two distinctive systems with evidence of chemosynthetic activity, explored at the SE Pacific margin off Chile (46°S and 33°S)

    Science.gov (United States)

    Muñoz, Práxedes; Cárdenas, Lissette J.; Garbe-Schönberg, Dieter; Sellanes, Javier; Dezileau, Laurent; Melville, Ives; Mendes, Stephanie D.

    2016-11-01

    dissociation, as observed in other cold-seep areas; and (b) correspond to clay mineral dehydration, as reported in plate subduction systems. The reducing conditions established at the CTJ conduct the Cd enrichment at a similar magnitude of that seen at the shallower suboxic site (EQSS). Evidence of chimney or vent fauna was not observed. At the EQSS, higher TOC and total sulfide contents were consistent with enhanced deposition of organic matter and reducing conditions developed in the OMZ, favoring the authigenic enrichment of Cd, U and Pb. The geochemical evidence, based only on methane concentrations and δ13DIC, is insufficient to establish the presence of methane seeps, as previously reported.

  9. Crustal Assimilation and Magma Recharge in the Recent Mt. Etna Magma Plumbing System: Evidence from In Situ Plagioclase Textural and Compositional Data

    Science.gov (United States)

    Pitcher, B. W.; Bohrson, W. A.; Viccaro, M.

    2011-12-01

    groundmass 87Sr/86Sr that are more radiogenic than plagioclase crystals, provide strong evidence of assimilation of a more radiogenic component over the timeframe of plagioclase crystallization. Additionally, large (>10) increases in An over a small spatial length (Tukey's test, provides a quantitative measure of the degree of dissimilarity between these various samples. Based on these tests, statistically significant differences (P value < 0.1) in parameters such as core to rim Δ87Sr/86Sr and ΔAn exist, and may indicate that crystal populations grew in distinct magma storage chambers within a complex plumbing system beneath Mt. Etna.

  10. LTDNA Evidence on Trial

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    Paul Roberts

    2016-10-01

    Full Text Available Adopting the interpretative/hermeneutical method typical of much legal scholarship, this article considers two sets of issues pertaining to LTDNA profiles as evidence in criminal proceedings. Section 1 addresses some rather large questions about the epistemic status and probative value of expert testimony in general. It sketches a theoretical model of expert evidence, highlighting five essential criteria: (1 expert competence; (2 disciplinary domain; (3 methodological validity; (4 materiality; and (5 legal admissibility. This generic model of expert authority, highlighting law’s fundamentally normative character, applies to all modern forms of criminal adjudication, across Europe and farther afield. Section 2 then examines English and Northern Irish courts’ attempts to get to grips with LTDNA evidence in recent cases. Better appreciating the ways in which UK courts have addressed the challenges of LTDNA evidence may offer some insights into parallel developments in other legal systems. Appellate court rulings follow a predictable judicial logic, which might usefully be studied and reflected upon by any forensic scientist or statistician seeking to operate effectively in criminal proceedings. Whilst each legal jurisdiction has its own unique blend of jurisprudence, institutions, cultures and historical traditions, there is considerable scope for comparative analysis and cross-jurisdictional borrowing and instruction. In the spirit of promoting more nuanced and sophisticated international interdisciplinary dialogue, this article examines UK judicial approaches to LTDNA evidence and begins to elucidate their underlying institutional logic. Legal argument and broader policy debates are not confined to considerations of scientific validity, contamination risks and evidential integrity, or associated judgments of legal admissibility or exclusion. They also crucially concern the manner in which LTDNA profiling results are presented and explained to

  11. Evidence on acne therapy

    Directory of Open Access Journals (Sweden)

    Caroline Sousa Costa

    Full Text Available Among the current treatments available for acne vulgaris, many widely practiced options lack support from studies at the best level of scientific evidence. The aim of this narrative review was to present the very latest information on topical and systemic treatments for acne vulgaris. Information from systematic reviews and well-designed clinical trials, obtained through a systematic search of the major medical databases, is emphasized. There are important issues regarding the clinical management of acne that still lack consistent grounding in scientific evidence. Among these are the optimum dose and duration of treatment with oral antibiotics that can be given without inducing bacterial resistance, and the safety of oral isotretinoin.

  12. Evidence or Advocacy?

    DEFF Research Database (Denmark)

    Buhl, Mie

    2015-01-01

    in the reform (Ministry of Education, 2013, 2014). My aim is to discuss the impact of the educational discourse of evidence in which all school subjects are defined in the new reform. The discourse of evidence focuses on competences aimed at utility and future employment prospects. The new learning objectives......Introduction This paper presents and discusses the current role of Danish visual arts education in the compulsory school system. Denmark recently implemented a major school reform “How to make a good school better” (Ministry of Education, 2014), that focuses on core competences in the subjects...... Reading and Math. The reform emphasizes an open approach to various constellations of teaching and learning and includes a national tool for increasing the assessment of core competences. I examined visual arts education in the new educational landscape based on the agreement between the government...

  13. Better Outcomes through Learning, Data, Engagement, and Research (BOLDER – a system for improving evidence and clinical practice in low and middle income countries [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    BOLDER Research Group

    2016-04-01

    Full Text Available Despite the many thousands of research studies published every year, evidence for making clinical decisions is often lacking. The main problem is that the evidence available is generated in conditions very different from those that prevail in routine clinical practice and with patients who are different. This is particularly a problem for low and middle income countries as most evidence is generated in high income countries. A group of clinicians, researchers, and policy makers met at Bellagio in Italy to consider how more relevant evidence might be generated. One answer is to conduct more pragmatic trials—those undertaken in routine clinical practice. The group thought that this might best be achieved by developing “learning health systems” in low and middle income countries. Learning health systems develop in communities that include clinicians, patients, researchers, improvement specialists, information technology specialists, managers, and policy makers and have a governance system that gives a voice to all those in the community. The systems focus on improving outcomes for patients, use a common dataset, and promote quality improvement and pragmatic research. Plans have been developed to create at least two learning systems in Africa.

  14. Antidepressant-like effect of the extract from leaves of Schinus molle L. in mice: evidence for the involvement of the monoaminergic system.

    Science.gov (United States)

    Machado, Daniele G; Kaster, Manuella P; Binfaré, Ricardo W; Dias, Munique; Santos, Adair R S; Pizzolatti, Moacir G; Brighente, Inês M C; Rodrigues, Ana Lúcia S

    2007-03-30

    Schinus molle L. (Anacardiaceae), among other uses, is popularly employed for the treatment of depression. In this study, the antidepressant-like effect of the hexanic extract from leaves of S. molle was investigated in the mouse tail suspension test (TST), a predictive model of depression. The immobility time in the TST was significantly reduced by the extract (dose range 30-600 mg/kg, p.o.), without accompanying changes in ambulation when assessed in an open-field test. The efficacy of extract was found to be comparable to that of fluoxetine (10 mg/kg, p.o.). The anti-immobility effect of the extract (100 mg/kg, p.o.) was prevented by pretreatment of mice with p-chlorophenylalanine methyl ester (PCPA, 100 mg/kg, i.p., an inhibitor of serotonin synthesis, for four consecutive days), NAN-190 (0.5 mg/kg, i.p., a 5-HT(1A) receptor antagonist), WAY100635 (0.1 mg/kg, s.c., a selective 5-HT(1A) receptor antagonist), ketanserin (5 mg/kg, i.p., a 5-HT(2A/2C) receptor antagonist), MDL72222 (0.1 mg/kg, i.p., a 5-HT(3) receptor antagonist), prazosin (1 mg/kg, i.p., an alpha(1)-adrenoceptor antagonist), yohimbine (1 mg/kg, i.p., an alpha(2)-adrenoceptor antagonist), SCH23390 (0.05 mg/kg, s.c., a D(1) receptor antagonist) or sulpiride (50 mg/kg, i.p., a D(2) receptor antagonist). It may be concluded that the hexanic extract of S. molle produces an antidepressant-like effect that seems to be dependent on its interaction with the serotonergic, noradrenergic and dopaminergic systems. These results provide evidence that the extract from S. molle shares with established antidepressants some pharmacological effects, at least at a preclinical level.

  15. Evidence of system: A network model case-study of seventh grade science assessment practices from classrooms to the state test

    Science.gov (United States)

    Piety, Philip John

    With science education in the United States entering a period of greater accountability, this study investigated how student learning in science was assessed by educators within one state, asking what systemic assessment approaches existed and how the information from them was used. Conducted during the 20o6-2007 school year, this research developed and piloted a network-model case study design that included teachers, principals, administrators, and the state test development process, as well as several state-level professional associations. The data analyzed included observations, interviews, surveys, and both public and private documents. Some data were secondary. This design produced an empirical depiction of practice with a web of related cases. The network model expands on the hierarchical (nested) models often assumed in the growing literature on how information is used in educational contexts by showing multiple ways in which individuals are related through organizational structures. Seven case study teachers, each employing assessment methods largely unique and invisible to others in their schools, illustrate one set of assessment practices. The only alternative to classroom assessments that could be documented was the annual state accountability test. These two assessment species were neither tightly coupled nor distinct. Some teachers were partners in developing state test instruments, and in some cases the annual test could be seen as a school management resource. Boundary practices---activities where these two systems connected---were opportunities to identify challenges to policy implementation in science education. The challenges include standards, cognition, vocabulary, and classroom equipment. The boundary practices, along with the web of connections, provide the outlines of potential (and often unrealized) synergistic relationships. This model shows diverse indigenous practices and adaptations by actors responding to pressures of change and

  16. Influence of intellectual impairment (II on basketball players´ capacity to solve a game situation: towards evidence-based classification systems in II-basketball

    Directory of Open Access Journals (Sweden)

    Javier PINILLA

    2016-07-01

    Full Text Available Basketball for athletes with intellectual impairment (II requires the development of evidence-based eligibility systems to guarantee that only athletes with significant limitations performing basketball participate in these competitions. In addition, this is needed to re-include IIbasketball in the Paralympic program. To do this, it is required to investigate how II impacts on fundamental basketball activities. To address this need, the aim of this study was to compare ablebodied (AB and II-players´ capacity to solve a game situation. A field test was designed ad hoc in which 38 elite II-players from France, Portugal, Australia and Japan who participated in the Global Games (2015 and 38 AB-basketball players competing in Spanish competitions, had to solve 8 standardized game situations. Results indicated that II-players spent significantly (p≤0.05 more time to decide (0.92±0.2s than AB-players (0.63±0.1s and to execute the solution (II: 3.01±0.4s; AB: 2.56±0.3s. Also, II-players made more rule infractions (II: 7.11±1.4; AB: 7.71±0.7, more feints (II:1.37±1.4; AB: 0.3±0.6, more dribbles (II: 15.08±3.9; AB: 12.29±2.3 and they performed less successful solutions (II: 4.42±1.5; AB: 5.39±1.3. However, no differences were found in number of correct decisions made. Decision time, number of dribbles and situations in which they succeeded were the variables that best discriminated between II and AB-players. These results confirmed the negative influence of II on players´ capacity to solve a basketball game situation. The calculated discriminant function let us establish the minimum scores from this test that indicates significant limitations on the capacity to solve a game situation. These scores are applicable to determine eligibility criteria in IIbasketball worldwide.

  17. Geomorphic evidence of active tectonics in the San Gorgonio Pass region of the San Andreas Fault system: an example of discovery-based research in undergraduate teaching

    Science.gov (United States)

    Reinen, L. A.; Yule, J. D.

    2014-12-01

    Student-conducted research in courses during the first two undergraduate years can increase learning and improve student self-confidence in scientific study, and is recommended for engaging and retaining students in STEM fields (PCAST, 2012). At Pomona College, incorporating student research throughout the geology curriculum tripled the number of students conducting research prior to their senior year that culminated in a professional conference presentation (Reinen et al., 2006). Here we present an example of discovery-based research in Neotectonics, a second-tier course predominantly enrolling first-and second-year students; describe the steps involved in the four week project; and discuss early outcomes of student confidence, engagement and retention. In the San Gorgonio Pass region (SGPR) in southern California, the San Andreas fault undergoes a transition from predominantly strike-slip to a complex system of faults with significant dip-slip, resulting in diffuse deformation and raising the question of whether a large earthquake on the San Andreas could propagate through the region (Yule, 2009). In spring 2014, seven students in the Neotectonics course conducted original research investigating quantifiable geomorphic evidence of tectonic activity in the SGPR. Students addressed questions of [1] unequal uplift in the San Bernardino Mountains, [2] fault activity indicated by stream knick points, [3] the role of fault style on mountain front sinuosity, and [4] characteristic earthquake slip determined via fault scarp degradation models. Students developed and revised individual projects, collaborated with each other on methods, and presented results in a public forum. A final class day was spent reviewing the projects and planning future research directions. Pre- and post-course surveys show increases in students' self-confidence in the design, implementation, and presentation of original scientific inquiries. 5 of 6 eligible students participated in research the

  18. Are mangroves in arid environments isolated systems? Life-history and evidence of dietary contribution from inwelling in a mangrove-resident shrimp species

    Science.gov (United States)

    Al-Maslamani, I.; Walton, M. E. M.; Kennedy, H. A.; Al-Mohannadi, M.; Le Vay, L.

    2013-06-01

    The Arabian Gulf represents one of the more northerly extremes of mangrove distribution in the Indo-Pacific, and is populated only by Avicennia marina, due to its tolerance of high salinity and wide temperature extremes. Recent studies suggest that in the arid coastal environment of the western Arabian Gulf, export of carbon and nitrogen from mangroves to adjacent habitats may be limited, though it is not clear if this is due to low productivity or physical factors such as the lack of freshwater flow and the tidal regime. Although seagrass and macroalgal habitats are relatively much more dominant by area, with only small pockets of mangrove around the edges of embayments, it is not evident if inwelling from these habitats support mangrove fauna. Year-round sampling in mangroves at Al-Khor, Qatar, indicates that Palaemon khori, an endemic shrimp species, is strongly associated with mangroves throughout its post-settlement life cycle, from recruitment as small 9-10 mm juveniles through to mating and egg production. Rapid post-recruitment growth (k = 1.8, L∞ = 42 mm for females, k = 1.5, L∞ = 35 mm for male) means that most individuals reached adult size in the first few months after settlement, with reproduction occurring in the following spring. As might be expected from year-round residence in the mangrove, dual 13C and 15N isotope analysis indicated a strong contribution of mangroves to shrimp tissue growth (Mean and 95% confidence range, 37% and 27-48%), but with a weaker significant contribution from particulate organic matter (20% and 1-37%), mangrove epiphytes (16% and 2-33%) and seagrasses (9% and 0.2-18%). Other primary producers contribute the remaining 18% to shrimp nutrition but the 95% confidence ranges include zero, suggesting possibly non-significant roles in supporting the shrimp population. This dietary information supports the view that fauna resident within arid mangrove systems are mainly dependent on localised retention and cycling of

  19. Late Pliocene To Pleistocene Tectonic Activity In SW Portugal: The S.Teotónio-Aljezur- Sinceira Fault System And Evidence For Coastal Uplift

    Science.gov (United States)

    Figueiredo, P.; Cabral, J.; Rockwell, T.

    2008-12-01

    Southwestern Portugal is located close to the Eurasia-Nubia plate boundary. East of the Gloria transform fault, this boundary becomes complex, particularly as it approaches the Gorringe Bank, the Horseshoe Plain, and the Gulf of Cadiz, where deformation related to the NW-SE convergence of Iberia and Nubia, at a rate of ~4-5 mm/ year, becomes distributed across a few hundred kilometer-wide zone. This area corresponds to the inferred seismogenic source zone for the 1755 earthquake and tsunami (estimated ≥ Mw 8), and also for the Mw 7.9 1969 event. During the past decade, several off-shore active folds and faults have been recognized in this region however, in spite of increased knowledge, none of the recognized active structures are clearly associated with the 1755 earthquake. Major likely sources are the Marquês de Pombal and Horseshoe faults. The Marquês de Pombal fault is a major NNE-SSW trending thrust located ~100 km SW of Cape S.Vicente that exhibits a ~1 km-high, 60 km-long scarp. Assuming rupture of this entire structure suggests earthquake magnitudes in the Mw 7.8 range. The Horseshoe fault, which is oriented NE- SW along a 175 km-long trend parallel to Säo Vicente canyon, a major morphological feature in the off- shore that has been interpreted as a possible extend for the Alentejo-Plasencia fault. Rupture of this entire fault could yield moment magnitude events up to Mw 8, assuming 10 m of average displacement. Neither of these potential sources can likely produce, by themselves, an earthquake that matches the upper estimates for the 1755 earthquake (Mw 8.7). Along the southwestern Portuguese coast, mainly at the western coastline, cliffs in Palaeozoic schist reach more than 100m in altitude, with evidence of uplift in the form of raised beach deposits, paleo-sea cliffs and multiple eolianite units. Several abrasion platforms with regional expression may have formed during multiple marine occupations. In contrast, the southern coast is underlain

  20. Spectroscopy of the D-wave q[bar q] system; evidence for two J[sup P] = 2[sup [minus

    Energy Technology Data Exchange (ETDEWEB)

    Ratcliff, B.N.; Aston, D.; Bienz, T.; Bird, F.; Dunwoodie, W.; Johnson, W.B.; Kunz, P.; Kwon, Y.; Leith, D.W.G.S.; Levinson, L.; Rensing, P.; Schultz, D.; Shapiro, S.; Sinervo, P.K.; Toge, N.; Waite, A.; Williams, S. (Stanford Linear Accelerator Center, Menlo Park, CA (United States)); Awaji, N.; Fujii, K.; Hayashii, H.; Iwata, S.; Kajikawa, R.; Matsui, T.; Miyamoto, A.; Ozaki, H.; Pak, C.O.; Shimomura, T.; Sugiyama, A.; Su

    1992-09-01

    Evidence is presented for two J[sup p] = 2[minus] strange mesons; one at [approx] 1.77 and the other at [approx] 1.82 GeV/c[sup 2]. These states have been observed in a partial wave analysis of the K[sup [minus

  1. The supratemporal system and the pattern of ramification of cephalic sensory canals in Denticeps clupeoides (Denticipitoidei, Teleostei: additional evidence for monophyly of Clupeiformes and Clupeoidei

    Directory of Open Access Journals (Sweden)

    Fabio Di Dario

    2006-01-01

    Full Text Available The cephalic portions of the latero-sensory canal system in Denticeps clupeoides are described and analyzed. The species, a small herring-like fish from relictual West African streams, is the most primitive living clupeomorph and sole Recent representative of suborder Denticipitoidei. As sister group to over 360 species in Clupeoidei, Denticeps is a key taxon in understanding clupeomorph and lower teleostean relationships. Observations on recently-collected specimens of Denticeps clupeoides revealed comparatively-important and previously-unrecorded details of the cephalic latero-sensory canals which are relevant for understanding relationships at different levels in clupeomorph phylogeny. The infraorbital, supraorbital, preopercular, extrascapular and post-temporal canals of Denticeps have unbranched tubules in soft tissue, as in the hypothesized plesiomorphic condition for lower teleosts. Contrastingly, the presence of a complex network formed by a high order of branching of cephalic canals is hypothesized as a synapomorphy of the Clupeoidei. Denticeps and the Clupeoidei share an exclusive sensory branch that originates at the junction between the extrascapular bone and the recessus lateralis, here hypothesized as an additional synapomorphy of Clupeiformes. A supratemporal system is newly recorded in Denticeps, and the character is proposed as a synapomorphy of Clupeiformes, and not of Clupeoidei as previously thought. The hypothesis that the supratemporal system is homologous to the supraorbital cavern is refuted, and the latter is corroborated as an autapomorphy of Denticeps. Another autapomorphy of Denticeps (or Denticipitoidei is the presence of the postorbital bulla, a hitherto unrecorded specialization of the infraorbital canal associated with infraorbitals 4 and 5. Homologies of other tubules of the cephalic sensory canals in Denticeps are also discussed, with emphasis on their bearing on the recognition of homologies of infraorbital

  2. The hospital library as a "magnet force" for a research and evidence-based nursing culture: A case study of two magnet hospitals in one health system.

    Science.gov (United States)

    Rourke, Diane Ream

    2007-01-01

    When Baptist Hospital of Miami, then South Miami Hospital, became Magnet award-winning hospitals, their libraries' challenges increased. Could their librarians ease the transition of research and evidence-based practice into the "real world" of nursing? Did library services have a role in the ongoing Magnet re-credentialing process? This case study defines hospital library magnet force strategies that worked in the quest for this prestigious award for nursing excellence at two hospitals at Baptist Health South Florida.

  3. Sistema visual humano: evidência psicofísica para filtros de freqüência angular baixa Human visual system: psychophysical evidence for low angular frequency filters

    Directory of Open Access Journals (Sweden)

    Natanael Antonio dos Santos

    2005-04-01

    Full Text Available O objetivo deste trabalho foi mensurar curvas de resposta ao contraste para os filtros de freqüências angulares de banda estreita de 1, 2, 3 e 4 ciclos/360º. Foram estimadas nove curvas para cada filtro com o método psicofísico de somação de resposta de supralimiar aliado ao método da escolha forçada. Tomaram parte neste experimento cinco participantes adultos com acuidade visual normal ou corrigida. Os resultados demonstraram somações máximas de limiar de contraste na freqüência de teste dos filtros de 1, 2, 3 e 4 ciclos/360º circundadas por inibições nas freqüências vizinhas às freqüências angulares de teste de cada filtro. Estes resultados são consistentes com a existência de filtros de freqüências angulares de banda estreita operando no sistema visual humano através do processo de somação ou inibição na faixa de freqüências angular baixa.The aim of this work was to measure narrow-band frequency response curves for four angular frequency filters whose test frequencies were 1, 2, 3 and 4 cycles/360º. Five human observers with normal or corrected visual acuity measured nine curves for each filter with a supra-threshold response summation psychophysical method allied within a forced-choice method. The results showed maximum summation effects at test frequency for filters 1, 2, 3 and 4 cycles/360º surrounded on both sides by strong inhibition. These results are consistent with the existence of narrow-band angular frequency filters operating in human visual system either through summation or inhibition of specific low angular frequency ranges.

  4. Power system fault diagnosis based on Petri net and D-S evidence theory%基于Petri网与D-S证据理论的电力系统故障诊断

    Institute of Scientific and Technical Information of China (English)

    刘妹琴; 王毅星

    2014-01-01

    The power system fault diagnosis problem was investigated in this paper .First ,the power system was modeled by a probability Petri net .Then based on this model ,the diagnosis information was obtained and fused with D-S (Dempster-Shafer) evidence theory .Finally ,the diagnosis result was concluded with the fusion performance .However ,the diagnosis result based on the D-S evidence the-ory may be contrary to the source evidence when dealing with the evidence ,of which some conflicts with each other .To solve the problem ,an improved fusion approach was proposed based on method of weighted average .With the method ,first the weight for each piece of evidence was calculated by its distance away from the average evidence ,which was inversely proportion to the weight .Then accord-ing to the D-S combination rules ,the final result was obtained by the iterative computation of the weighted average evidence .With the proposed approach ,better fusion performances were achieved and higher efficiencies were guaranteed .And the simulation results proved the effectiveness of this ap-proach .%针对电力系统继电保护故障,利用概率Petri网对电力系统进行建模,获取有效的故障信息,并运用D-S(Dempster-Shafer)证据理论对信息进行融合,得出诊断结果。针对传统D-S证据理论在处理冲突证据时会存在结果与源证据相悖的问题,在加权平均法的基础上提出一种改进的融合方法,根据各个证据到平均证据的距离与证据权重大小成反比的关系,计算每个证据的权重,再进行加权平均,最后利用D-S组合规则进行迭代计算。与传统方法相比,本文方法拥有更好的融合效果和更高的效率。仿真结果验证了改进方法的有效性。

  5. Policy implications and impact of household registration system on Peasants’ Willingness to return rural residential lands: Evidence from household survey in rural China

    Directory of Open Access Journals (Sweden)

    Hengzhou Xu

    2016-01-01

    Full Text Available Despite a growing body of literature on China’s household registration system and rural land transfer, few studies have examined the impact of the household registration system on peasants’ willingness to return rural residential land. This paper aims to fill this gap and uses household survey data to measure the impacts of household registration system on peasants’ willingness to return rural residential land. The results show that the household registration system reduced the farmers’ enthusiasm to exit the rural residential land, that is, household registration system had a significant negative impact on farmers’ willingness to return rural residential land.

  6. Evidence-Based IT Development

    DEFF Research Database (Denmark)

    Simonsen, Jesper; Hertzum, Morten

    2005-01-01

    Evidence-based IT development aims at developing a new commercial contract model for IT projects where the cus-tomers payment is dependent on measurable effects of using the vendors system. The idea is to establish a strategic part-nership in which customer and IT vendor share the responsi-bility...

  7. Improved evidence theory and its application in fault diagnosis of power system%改进证据理论及其在电力系统故障诊断中的应用

    Institute of Scientific and Technical Information of China (English)

    李玲玲; 景丽婷; 马东娟; 李志刚

    2012-01-01

    针对D-S证据理论中高度冲突的证据难以融合的问题,提出一种基于海明距离的证据合成规则.首先根据冲突系数的大小判断证据冲突程度,利用海明距离确定的相似度区分每条证据,并赋予权重,然后对原始基本信度分配函数进行重新分配,最终得到更加合理的合成结果.将该数据融合方法用于电力系统的故障诊断实例中,表明该方法合理有效,计算结果更符合实际.%A new Dempster-Shafer evidence combination rule based on the Hamming distance was proposed aiming at solving the fusion problem of highly conflicting evidence. At first, we judged the evidence conflict degree according to the size of the conflict coefficient, the Hamming distance was used to determine the similarity to distinguish each of evidence, and the weight was given to the evidence. Then the original basic probability distribution function was redistributed, finally the more reasonable the syncretic result was obtained. At last, the data fusion method was applied to power system fault diagnosis example, the calculation result indicated that the method was effective and reasonable, and the conclusion was more actual.

  8. Perceptions of the health system and public trust in government in low- and middle-income countries: evidence from the World Health Surveys.

    Science.gov (United States)

    Rockers, Peter C; Kruk, Margaret E; Laugesen, Miriam J

    2012-06-01

    In low- and middle-income countries, health care systems are an important means by which individuals interact with their government. As such, aspects of health systems in these countries may be associated with public trust in government. Greater trust in government may in turn improve governance and government effectiveness. We identify health system and non-health system factors hypothesized to be associated with trust in government and fit several multilevel regression models to cross-national data from 51,300 respondents in thirty-eight low- and middle-income countries participating in the World Health Surveys. We find that health system performance factors are associated with trust in government while controlling for a range of non-health system covariates. Taken together, higher technical quality of health services, more responsive service delivery, fair treatment, better health outcomes, and financial risk protection accounted for a 13 percentage point increase in the probability of having trust in government. Health system performance and good governance may be more inter-related than previously thought. This finding is particularly important for low-income and fragile states, where health systems and governments tend to be weakest. Future research efforts should focus on determining the causal mechanisms that underlie the observed associations between health system performance and trust in government.

  9. The role of health systems and policy in producing behavior and social change to enhance child survival and development in low- and middle-income countries: an examination of the evidence.

    Science.gov (United States)

    Vélez, Luis F; Sanitato, Mary; Barry, Donna; Alilio, Martin; Apfel, Franklin; Coe, Gloria; Garcia, Amparo; Kaufman, Michelle; Klein, Jonathan; Kutlesic, Vesna; Meadowcroft, Lisa; Nilsen, Wendy; O'Sullivan, Gael; Peterson, Stefan; Raiten, Daniel; Vorkoper, Susan

    2014-01-01

    Evidence-based behavior change interventions addressing health systems must be identified and disseminated to improve child health outcomes. Studies of the efficacy of such interventions were identified from systematic searches of the published literature. Two hundred twenty-nine of the initially identified references were judged to be relevant and were further reviewed for the quality and strength of the evidence. Studies were eligible if an intervention addressed policy or health systems interventions, measured relevant behavioral or health outcomes (e.g., nutrition, childhood immunization, malaria prevention and treatment), used at least a moderate quality research design, and were implemented in low- or middle-income countries. Policy or systems interventions able to produce behavior change reviewed included media (e.g., mass media, social media), community mobilization, educational programs (for caregivers, communities, or providers), social marketing, opinion leadership, economic incentives (for both caregiver and provider), health systems strengthening/policy/legislation, and others. Recommendations for policy, practice, and research are given based on fairly strong data across the areas of health service delivery, health workforce, health financing, governance and leadership, and research.

  10. Evidence for ground-rupturing earthquakes on the Northern Wadi Araba fault at the archaeological site of Qasr Tilah, Dead Sea Transform fault system, Jordan

    Science.gov (United States)

    Haynes, Jeremy M.; Niemi, Tina M.; Atallah, Mohammad

    2006-10-01

    The archaeological site of Qasr Tilah, in the Wadi Araba, Jordan is located on the northern Wadi Araba fault segment of the Dead Sea Transform. The site contains a Roman-period fort, a late Byzantine Early Umayyad birkeh (water reservoir) and aqueduct, and agricultural fields. The birkeh and aqueduct are left-laterally offset by coseismic slip across the northern Wadi Araba fault. Using paleoseismic and archaeological evidence collected from a trench excavated across the fault zone, we identified evidence for four ground-rupturing earthquakes. Radiocarbon dating from key stratigraphic horizons and relative dating using potsherds constrains the dates of the four earthquakes from the sixth to the nineteenth centuries. Individual earthquakes were dated to the seventh, ninth and eleventh centuries. The fault strand that slipped during the most recent event (MRE) extends to just below the modern ground surface and juxtaposes alluvial-fan sediments that lack in datable material with the modern ground surface, thus preventing us from dating the MRE except to constrain the event to post-eleventh century. These data suggest that the historical earthquakes of 634 or 659/660, 873, 1068, and 1546 probably ruptured this fault segment.

  11. Treatment Efficacy of Integrative Family and Systems Treatment (I-FAST) With and Without Consultation: The Role of Model Training in the Sustainability of Evidence-Based Family Treatments.

    Science.gov (United States)

    Lee, Mo Yee; Hsu, Kai-Shyang; Liu, Chang; Greene, Gilbert J; Fraser, J Scott; Grove, David; Solovey, Andy; Edwards, Shivani G; Scott, Pam

    2016-07-01

    This study examined the efficacy of the Integrative Family and Systems Treatment (I-FAST) training model that seeks to support development of model expertise within the agency in the context of facilitating the sustainability of evidence-based family treatment within community mental health settings. A quasi-experimental design was used to examine treatment outcomes of I-FAST among agencies that received ongoing Consultation and agencies that received No Consultation upon completion of I-FAST training. χ (2) analyses and independent samples t test analyses showed that there were no significant differences between the two groups on clients who had achieved reliable change on Problem Severity and Functioning based on parents' assessments. Significance of this study is discussed in the context of the role of evidence-based family therapy (EBFT) training in facilitating its sustainability in community mental health settings.

  12. Balancing innovation and evidence.

    Science.gov (United States)

    Pilcher, Jobeth W

    2015-01-01

    Nurse educators are encouraged to use evidence to guide their teaching strategies. However, evidence is not always available. How can educators make decisions regarding strategies when data are limited or absent? Where do innovation and creativity fit? How can innovation be balanced with evidence? This article provides a discussion regarding other sources of evidence, such as extrapolations, theories and principles, and collective expertise. Readers are encouraged to review the options and then analyze how they might be applied to innovation in education.

  13. Evidence of Hydrogeological Connection between the Mountain and Plio-Plistocene Aquifer Systems, Using Pharmaceutical Residual- case study Jericho area/Lower Jordan Valley

    Science.gov (United States)

    Marei, Amer; Schmidt, Natali; Tiehm, Andreas

    2013-04-01

    Jericho Oases (-258 m b.s.l) is known through the history for its fertile soil, date trees, and sweet fruits. Groundwater is the only water sources for domestic and agricultural activities, where about 8 MCM/a discharge form three major springs groups, in addition to 20 MCM are taped from 45 shallow boreholes (10-180 m) in the Plio-Plistocene aquifer system. The current and future availability of groundwater of the shallow Plio-Plistocene aquifer system is the key factor for the economical development of agricultural sector, where during the last 10 years around 50 million USD are invested in this sector. Green houses agriculture, and date trees farming become the major groundwater consumers. From the hydrological point view, the study area is part of the eastern Wadi Al Quilt drainage system, where recharge take place along the mountain range in the western part of the catchment area. The shallow aquifer system consists of gravel; sand and silt inter fingering with clay layers. Chalk and chalky limestone formation of Senonian age separate the shallow aquifer from Mountain aquifer which consists of limestone, and dolomite. Both aquifer systems are part from the Eastern Basin where groundwater flows towards the Jordan River-Dead Sea basin. Direct recharge from rainfall to the shallow aquifer system is neglected due to the high evaporation rates, and only about 1 MCM/a of flooding water infiltrate into this aquifer. The hypotheses of this study is an indirect groundwater replenishment take places in certain sites along the N-S-major fault system, and groundwater flow through passages into the Plio-Plistocene aquifer systems. We tried to use pharmaceutical residuals to trace groundwater flow regimes in the Mountain and Plio-Plistocene aquifer system. Twenty eight water samples were collected during the hydrological year 2011 (in March and July) from 19 sampling sites (springs and boreholes). Few samples were collected from Al Bereh waste water treatment plant as well

  14. Evidence and evidence gaps – an introduction

    Science.gov (United States)

    Dreier, Gabriele; Löhler, Jan

    2016-01-01

    Background: Medical treatment requires the implementation of existing evidence in the decision making process in order to be able to find the best possible diagnostic, therapeutic or prognostic measure for the individual patient based on the physician’s own expertise. Clinical trials form the evidence base and ideally, their results are assembled, analyzed, summarized, and made available in systematic review articles. Beside planning, conducting, and evaluating clinical trials in conformity with GCP (good clinical practice), it is essential that all results of conducted studies are publicly available in order to avoid publication bias. This includes also the public registration of planned and cancelled trials. History: During the last 25 years, evidence-based medicine became increasingly important in medical care and research. It is closely associated with the names of Archibald Cochrane and David Sackett. About 15 years ago, the Deutsche Cochrane Zentrum (Cochrane Germany) and the Deutsche Netzwerk Evidenzbasierte Medizin e.V. (German Network for Evidence-based Medicine, DNEbM) were founded in Germany. In the International Cochrane Collaboration, clinicians and methodologists come together on an interdisciplinary level to further develop methods of evidence-based medicine and to discuss the topics of evidence generation and processing as well as knowledge transfer. Problem: Evidence is particularly important for physicians in the process of decision making, however, at the same time it is the base of a scientific proof of benefit for the patient and finally for the payers in health care. The closure of evidence gaps requires enormously high staff and financial resources, significant organizational efforts, and it is only successful when clinical and methodical expertise as well as specific knowledge in the field of clinical research are included. On the other hand, the knowledge has to be transferred into practice. For this purpose, practice guidelines, meetings

  15. New results for the formation of a muoniated radical in the Mu + Br2 system: a van der Waals complex or evidence for vibrational bonding in Br-Mu-Br?

    Science.gov (United States)

    Fleming, Donald G; Cottrell, Stephen P; McKenzie, Iain; Macrae, Roderick M

    2012-08-21

    New evidence is presented for the observation of a muoniated radical in the Mu + Br(2) system, from μSR longitudinal field (LF) repolarisation studies in the gas phase, at Br(2) concentrations of 0.1 bar in a Br(2)/N(2) mixture at 300 K and at 10 bar total pressure. The LF repolarisation curve, up to a field of 4.5 kG, reveals two paramagnetic components, one for the Mu atom, formed promptly during the slowing-down process of the positive muon, with a known Mu hyperfine coupling constant (hfcc) of 4463 MHz, and one for a muoniated radical formed by fast Mu addition. From model fits to the Br(2)/N(2) data, the radical component is found to have an unusually high muon hfcc, assessed to be ∼3300 MHz with an overall error due to systematics expected to exceed 10%. This high muon hfcc is taken as evidence for the observation of either the Br-Mu-Br radical, and hence of vibrational bonding in this H[combining low line]-L[combining low line]-H[combining low line] system, or of a MuBr(2) van der Waals complex formed in the entrance channel. Preliminary ab initio electronic structure calculations suggest the latter is more likely but fully rigorous calculations of the effect of dynamics on the hfcc for either system have yet to be carried out.

  16. Iceland Deep Drilling Project: (V) Isotopic Evidence of Hydrothermal Exchange and Seawater Ingress from Alteration Minerals in the Reykjanes Geothermal System

    Science.gov (United States)

    Marks, N. E.; Zierenberg, R. A.; Schiffman, P.

    2009-12-01

    The Reykjanes geothermal system is a seawater recharged hydrothermal system located on the landward extension of the Mid-Atlantic Ridge in Iceland. Fluid compositions in the system have evolved through time as a result of changing proportions of meteoric water as well as differing pressure and temperature conditions imposed by glaciation (Sveinbjornsdottir, 1986; Fridleifsson et al., 2005; Marks et al., 2009). Samples from the deepest part of Reykjanes well RN-17 include greenschist to pyroxene hornfels facies assemblages, suggesting seawater penetration into a part of the system that is close to the high temperature reaction zone. Electron microprobe studies of drill cuttings reveal intense alteration of hyaloclastites with calc-silicate alteration assemblages comprising calcic hydrothermal plagioclase, grandite garnet, prehnite, epidote, hydrothermal clinopyroxene, and titanite. In contrast, crystalline basalts and intrusive rocks display a wide range in alteration intensity from essentially unaltered to pervasive and nearly complete replacement of feldspar and pyroxene. Epidote is widely distributed throughout the RN-17 samples and fills veins and vugs, replaces glass in hyaloclastites and the interstitial matrix of basalt samples, and is also an alteration product of primary plagioclase. 87Sr/86Sr values of individual epidote grains measured by LA-ICPMS were typically 0.7045-0.7050, but ranged as high as 0.7073 in individual grains. Anhydrite is widespread in shallow portions of the Reykjanes system to about 1500 m. 87Sr/86Sr values of anhydrite from the Reykjanes geothermal system range from 0.7044-0.7053, and gypsum values range from 0.7093 to 0.7094. The Sr isotopic ratios of alteration minerals are shifted from basaltic values (0.7030-0.7034; O’Nions and Grönvold, 1973; Sun and Jahn, 1975) toward seawater values (0.70916; Palmer and Edmond, 1989). This suggests that seawater Sr is able to penetrate deep within the geothermal system, and that seawater Sr

  17. PET Imaging with [(18)F]FSPG Evidences the Role of System xc(-) on Brain Inflammation Following Cerebral Ischemia in Rats.

    Science.gov (United States)

    Domercq, Maria; Szczupak, Boguslaw; Gejo, Jon; Gómez-Vallejo, Vanessa; Padro, Daniel; Gona, Kiran Babu; Dollé, Frédéric; Higuchi, Makoto; Matute, Carlos; Llop, Jordi; Martín, Abraham

    2016-01-01

    In vivo Positron Emission Tomography (PET) imaging of the cystine-glutamate antiporter (system xc(-)) activity with [(18)F]FSPG is meant to be an attractive tool for the diagnosis and therapy evaluation of brain diseases. However, the role of system xc(-) in cerebral ischemia and its involvement in inflammatory reaction has been scarcely explored. In this work, we report the longitudinal investigation of the neuroinflammatory process following transient middle cerebral artery occlusion (MCAO) in rats using PET with [(18)F]FSPG and the translocator protein (TSPO) ligand [(18)F]DPA-714. In the ischemic territory, [(18)F]FSPG showed a progressive binding increase that peaked at days 3 to 7 and was followed by a progressive decrease from days 14 to 28 after reperfusion. In contrast, [(18)F]DPA-714 evidenced maximum binding uptake values over day 7 after reperfusion. Ex vivo immnunohistochemistry confirmed the up-regulation of system xc(-) in microglial cells and marginally in astrocytes. Inhibition of system xc(-) with sulfasalazine and S-4-CPG resulted in increased arginase (anti-inflammatory M2 marker) expression at day 7 after ischemia, together with a decrease in TSPO and microglial M1 proinflammatory markers (CCL2, TNF and iNOS) expression. Taken together, these results suggest that system xc(-) plays a key role in the inflammatory reaction underlying experimental stroke.

  18. XPS evidence for structure-performance relationship in selective hydrogenation of crotonaldehyde to crotyl alcohol on platinum systems supported on natural phosphates.

    Science.gov (United States)

    Hidalgo-Carrillo, Jesús; Sebti, Jalila; Marinas, Alberto; Marinas, José M; Sebti, Said; Urbano, Francisco J

    2012-09-15

    Natural phosphates are an important natural resource in Morocco, which needs to be valorised. They can be used not only as fertilisers but also as catalysts. Here, we report for the first time on its use as support for platinum and the application of the resulting systems to the liquid-phase selective hydrogenation of an α,β-unsaturated carbonyl compound (crotonaldehyde) to the corresponding unsaturated alcohol (crotyl alcohol), a process of interest in the production of pharmaceuticals, agrochemicals and fragrances. Catalytic results are related to the surface solid structure as determined by XPS. Therefore, the most active systems showed new surface interactions as evidenced by the appearance of new P, O, Ca, F and C peaks and the shift of Pt ones to lower binding energies. Further modification of the most active system with FeCl(2) led to 70% selectivity to crotyl alcohol at 34% conversion.

  19. Negative correlation of 129I/127I and 129Xe/132Xe: product of closed system evolution or evidence of a mixed component.

    Science.gov (United States)

    Gilmour, J. D.; Whitby, J. A.; Turner, G.

    2001-10-01

    Anti-correlation of initial iodine ratios with trapped 129Xe/132Xe ratios has been interpreted as resulting from 129I decay to 129Xe in a closed system. However, many of the 129Xe/132Xe ratios that contribute to the anti-correlations are lower than 1.04, the value characteristic of major solar system reservoirs; 129I decay cannot lead to a decrease in this ratio. We offer an alternative explanation for the anti-correlations, based on trapped iodine and xenon components similar to those observed in Nakhla, that does not require the existence of components with 129Xe/132Xe lower than solar.

  20. Conspiracist ideation in Britain and Austria: evidence of a monological belief system and associations between individual psychological differences and real-world and fictitious conspiracy theories.

    Science.gov (United States)

    Swami, Viren; Coles, Rebecca; Stieger, Stefan; Pietschnig, Jakob; Furnham, Adrian; Rehim, Sherry; Voracek, Martin

    2011-08-01

    Despite evidence of widespread belief in conspiracy theories, there remains a dearth of research on the individual difference correlates of conspiracist ideation. In two studies, we sought to overcome this limitation by examining correlations between conspiracist ideation and a range of individual psychological factors. In Study 1, 817 Britons indicated their agreement with conspiracist ideation concerning the July 7, 2005 (7/7), London bombings, and completed a battery of individual difference scales. Results showed that stronger belief in 7/7 conspiracy theories was predicted by stronger belief in other real-world conspiracy theories, greater exposure to conspiracist ideation, higher political cynicism, greater support for democratic principles, more negative attitudes to authority, lower self-esteem, and lower Agreeableness. In Study 2, 281 Austrians indicated their agreement with an entirely fictitious conspiracy theory and completed a battery of individual difference measures not examined in Study 1. Results showed that belief in the entirely fictitious conspiracy theory was significantly associated with stronger belief in other real-world conspiracy theories, stronger paranormal beliefs, and lower crystallized intelligence. These results are discussed in terms of the potential of identifying individual difference constellations among conspiracy theorists.

  1. Filling in the Implementation Gap? Problems in the Greek Educational System--An Evidence-Based Explanatory Framework and Critical Reflections

    Science.gov (United States)

    Kyridis, Argyris; Fotopoulos, Nikos; Chronopoulou, Ageliki; Papadakis, Nikos; Zagkos, Christos

    2011-01-01

    The Greek educational system during last 50 years recounts among numerous reformations and counterreformations. All the continuous changes seem not to be characterized by a clearly defined operational aim and rational continuity. Currently, educators, pupils, university students, parents, politicians and citizens criticize various structural and…

  2. Implications for organic maturation studies of evidence of a geologically rapid increase and stabilization of vitrinite reflectance at peak temperature: Cerro Prieto geothermal system, Mexico

    Science.gov (United States)

    Barker, C.E.

    1991-01-01

    A short-term rapid heating and cooling of the rock in well M-94 below 1300 m was caused by a pulse of hot water passing through the edge of the Cerro Prieto, Mexico, geothermal system. Below 1300 m, the peak paleotemperatures were about 225-250??C, but equilibrium well log temperatures indicate a decrease to 150-210??C at present. This hot water pulse sharply increased vitrinite reflectance to levels comparable to those measured in the central part of the system, even though studies of apatite fission-track annealing indicate that the duration of heating was only 100-101 yr in M-94, in contrast to 103-104 yr in the central part of the system. The quick change of the vitrinite reflectance geothermometer indicates that thermal maturation reactions can stabilize, after a geologically short period of heating, to a level consistent with peak temperature under moderate to high-temperature diagenesis in open, fluid-rich, geothermal systems. -from Author

  3. Product-Service System Design Approach for the Base of the Pyramid Markets: Practical Evidence from the Energy Sector in the Brazilian Context

    NARCIS (Netherlands)

    Da Costa Junior, J.; Diehl, J.C.

    2013-01-01

    In Emerging Markets, the product-service system (PSS) design approach may represent a promising solution as a socially and environmentally sound path to economic development. In addition, the energy sector has a major role for the social-economic development and is central to poverty alleviation. Th

  4. Construct Validity of the Behavior Assessment System for Children (BASC) Self-Report of Personality: Evidence from Adolescents Referred to Residential Treatment

    Science.gov (United States)

    Weis, Robert; Smenner, Lindsey

    2007-01-01

    The authors investigate the construct validity of the Behavior Assessment System for Children Self-Report of Personality (BASC-SRP; Reynolds & Kamphaus, 1998). A sample of 970 adolescents (16-18 years) with histories of disruptive behavior problems and truancy complete the SRP; a subsample of 290 adolescents also completed the Minnesota…

  5. Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization

    DEFF Research Database (Denmark)

    Scheel, Troels Kasper Høyer; Gottwein, Judith Margarete; Jensen, Tina Birk

    2008-01-01

    in serial passages. Sequence analysis of recovered viruses and subsequent reverse genetic studies revealed a vital dependence on one or two NS2 mutations, depending on the 4a/2a junction. Infectivity of ED43/JFH1 viruses was CD81 dependent. The genotype 4 cell culture systems permit functional analyses...

  6. Transport of D-xylose in Lactobacillus pentosus, Lactobacillus casei, and Lactobacillus plantarum: Evidence for a mechanism of facilitated diffusion via the phosphoenolpyruvate:mannose phosphotransferase system

    NARCIS (Netherlands)

    Chaillou, S.; Pouwels, P.H.; Postma, P.W.

    1999-01-01

    We have identified and characterized the D-xylose transport system of Lactobacillus pentosus. Uptake of D-xylose was not driven by the proton motive force generated by malolactic fermentation and required D-xylose metabolism. The kinetics of D-xylose transport were indicative of a low- affinity faci

  7. The Proto-Indo-European case system and its reflexes in a diachronic typological perspective : Evidence for the linguistic prehistory of Eurasia

    NARCIS (Netherlands)

    Kulikov, L.I.

    2012-01-01

    The paper outlines a diachronic typology of changes in case systems within the Indo-European linguistic family. This study is written in the genre of identification and definition of problem: I will not attempt to offer an exhaustive treatment of the subject. Rather, I would like to draw attention t

  8. Synthesizing Evidence: Synthesis Methods for Evidence Clearinghouses

    Science.gov (United States)

    Valentine, Jeff; Lau, Timothy

    2015-01-01

    Following the theme of the first two presentations, this presentation will focus on the choices available for research synthesis when summarizing research evidence. The presenters will describe the current research synthesis practice of the What Works Clearinghouse (WWC) as well as several alternative models, including inverse-variance weighted…

  9. Evidence of weak ferromagnetism in the C14 Laves phase (Fe{sub 1-x}Co{sub x}){sub 2}Nb system

    Energy Technology Data Exchange (ETDEWEB)

    Paduani, C. [DF-UFSC, Florianopolis, CEP 88040-900, SC (Brazil)], E-mail: paduani@fisica.ufsc.br; Schaf, J. [IF-UFRGS, Porto Alegre, CEP 91501-970, RS (Brazil); Persiano, A.I.C. [DF-ICEX-UFMG, Belo Horizonte, CP 702, 30161-970 MG (Brazil); Ardisson, J.D. [CDTN, Belo Horizonte, CEP 30123-970, MG (Brazil); Takeuchi, A.Y. [DF-UFES, Vitoria, CEP 29075-910, ES (Brazil); Raposo, M.T. [DCNAT-UFSJ, Sao Joao Del Rei, CEP 36300-000, MG (Brazil)

    2009-04-17

    In this work are studied the structure and magnetic properties of the (Fe{sub 1-x}Co{sub x}){sub 2}Nb alloys with X-ray diffraction and magnetization measurements. The results confirm the formation of the C14 Laves phase in the Co concentration range 0{<=}x{<=}0.55. The unit cell volume decreases with the increase of the cobalt concentration and is larger than in Fe{sub 2}Nb. Magnetization measurements indicate that this system is weakly ferromagnetic at low temperatures for x{<=}0.55. From the behavior of the M(T) curves a cluster-glass-like mechanism is predicted for this system below 50 K.

  10. Enriched Environment Increases PCNA and PARP1 Levels in Octopus vulgaris Central Nervous System: First Evidence of Adult Neurogenesis in Lophotrochozoa.

    Science.gov (United States)

    Bertapelle, Carla; Polese, Gianluca; Di Cosmo, Anna

    2017-03-02

    Organisms showing a complex and centralized nervous system, such as teleosts, amphibians, reptiles, birds and mammals, and among invertebrates, crustaceans and insects, can adjust their behavior according to the environmental challenges. Proliferation, differentiation, migration, and axonal and dendritic development of newborn neurons take place in brain areas where structural plasticity, involved in learning, memory, and sensory stimuli integration, occurs. Octopus vulgaris has a complex and centralized nervous system, located between the eyes, with a hierarchical organization. It is considered the most "intelligent" invertebrate for its advanced cognitive capabilities, as learning and memory, and its sophisticated behaviors. The experimental data obtained by immunohistochemistry and western blot assay using proliferating cell nuclear antigen and poli (ADP-ribose) polymerase 1 as marker of cell proliferation and synaptogenesis, respectively, reviled cell proliferation in areas of brain involved in learning, memory, and sensory stimuli integration. Furthermore, we showed how enriched environmental conditions affect adult neurogenesis.

  11. The Impact of Integrated Practices of Lean, Green, and Social Management Systems on Firm Sustainability Performance—Evidence from Chinese Fashion Auto-Parts Suppliers

    Directory of Open Access Journals (Sweden)

    Lin Wu

    2015-03-01

    Full Text Available To better satisfy various stakeholders, firms are seeking integrated practices that can enhance their sustainability performance, also well known as the Triple Bottom Line (3BL. The fashion industry exhibits potential conflicts with the spirit of sustainability because of the waste created by high levels of demand uncertainty and the extant usage of resources in production. Literature suggests that selected stand-alone practices of lean, green, and Corporate Social Responsibility (CSR management systems have a positive impact on firm sustainability performance. However, how the combination of selected practices from these three management systems impacts the 3BL remains unclear. Based on case studies, we build an integrated sustainable practices model incorporating the most popular lean, green, and social practices and develop propositions for future tests. Our framework suggests the implementation of integrated practices would have a stronger influence on 3BL performance than individual practice implementation.

  12. CXC Chemokine Ligand 10 Controls Viral Infection in the Central Nervous System: Evidence for a Role in Innate Immune Response through Recruitment and Activation of Natural Killer Cells

    OpenAIRE

    Trifilo, Matthew J.; Montalto-Morrison, Cynthia; Stiles, Linda N.; Hurst, Kelley R.; Hardison, Jenny L.; Manning, Jerry E.; Masters, Paul S.; Lane, Thomas E.

    2004-01-01

    How chemokines shape the immune response to viral infection of the central nervous system (CNS) has largely been considered within the context of recruitment and activation of antigen-specific lymphocytes. However, chemokines are expressed early following viral infection, suggesting an important role in coordinating innate immune responses. Herein, we evaluated the contributions of CXC chemokine ligand 10 (CXCL10) in promoting innate defense mechanisms following coronavirus infection of the C...

  13. Evidence-based rules from family practice to inform family practice; the learning healthcare system case study on urinary tract infections.

    OpenAIRE

    Soler, Jean K; Corrigan, Derek; Kazienko, Przemyslaw; Kajdanowicz, Tomasz; Danger, Roxana; Kulisiewicz, Marcin; Delaney, Brendan

    2015-01-01

    Background Analysis of encounter data relevant to the diagnostic process sourced from routine electronic medical record (EMR) databases represents a classic example of the concept of a learning healthcare system (LHS). By collecting International Classification of Primary Care (ICPC) coded EMR data as part of the Transition Project from Dutch and Maltese databases (using the EMR TransHIS), data mining algorithms can empirically quantify the relationships of all presenting reasons for encounte...

  14. The evolution of jumping in frogs: morphological evidence for the basal anuran locomotor condition and the radiation of locomotor systems in crown group anurans.

    Science.gov (United States)

    Reilly, Stephen M; Jorgensen, Michael E

    2011-02-01

    Our understanding of the evolution of frog locomotion follows from the work of Emerson in which anurans are proposed to possess one of three different iliosacral configurations: 1) a lateral-bending system found in walking and hopping frogs; 2) a fore-aft sliding mechanism found in several locomotor modes; and 3) a sagittal-hinge-type pelvis posited to be related to long-distance jumping performance. The most basal living (Ascaphus) and fossil (Prosalirus) frogs are described as sagittal-hinge pelvic types, and it has been proposed that long-distance jumping with a sagittal-hinge pelvis arose early in frog evolution. We revisited osteological traits of the pelvic region to conduct a phylogenetic analysis of the relationships between pelvic systems and locomotor modes in frogs. Using two of Emerson's diagnostic traits from the sacrum and ilium and two new traits from the urostyle, we resampled the taxa originally studied by Emerson and key paleotaxa and conducted an analysis of ancestral-character state evolution in relation to locomotor mode. We present a new pattern for the evolution of pelvic systems and locomotor modes in frogs. Character analysis shows that the lateral-bender, walker/hopper condition is both basal and generally conserved across the Anura. Long-distance jumping frogs do not appear until well within the Neobatrachia. The sagittal-hinge morphology is correlated with long-distance jumping in terrestrial frogs; however, it evolved convergently multiple times in crown group anurans with the same four pelvic traits described herein. Arboreal jumping has appeared in multiple crown lineages as well, but with divergent patterns of evolution involving each of the three pelvic types. The fore-aft slider morph appears independently in three different locomotor modes and, thus, is a more complex system than previously thought. Finally, it appears that the advent of a bicondylar sacro-urostylic articulation was originally related to providing axial rigidity

  15. Properties of QSO Metal Line Absorption Systems at High Redshifts: Nature and Evolution of the Absorbers and New Evidence on Escape of Ionizing Radiation from Galaxies

    CERN Document Server

    Boksenberg, Alec

    2014-01-01

    Using Voigt-profile-fitting procedures on Keck HIRES spectra of nine QSOs we identify 1099 CIV absorber components clumped in 201 systems outside the Lyman forest over 1.6 < z < 4.4. With associated SiIV, CII, SiII and NV where available we investigate bulk statistical and ionization properties of the components and systems and find no significant change in redshift for CIV and SiIV while CII, SiII and NV change substantially. The CIV components exhibit strong clustering but no clustering is detected for systems on scales from 150 km/s out to 50000 km/s. We conclude the clustering is due entirely to the peculiar velocities of gas present in the circumgalactic media of galaxies. Using specific combinations of ionic ratios we compare our observations with model ionization predictions for absorbers exposed to the metagalactic ionizing radiation background augmented by proximity radiation from their associated galaxies and find the generally accepted means of radiative escape by transparent channels from th...

  16. Experimental evidence for an optical interference model for vibrational sum frequency generation on multilayer organic thin film systems. II. Consideration for higher order terms.

    Science.gov (United States)

    O'Brien, Daniel B; Massari, Aaron M

    2015-01-14

    The generalized optical interference model for interfacial contributions to vibrational sum frequency generation (VSFG) spectroscopic signals from organic thin film systems is extended to include a description of optical interferences contained in the thin film bulk response. This is based on electric quadrupolar interactions with the input fields and includes a discussion on possible contribution from the electric quadrupolar polarization. VSFG data from the first of this two part report are analyzed and include effects from higher order responses, for both bulk and higher order interfacial terms. The results indicate that although it is capable of capturing many of the data features, the electric dipole treatment is likely not a complete description of the VSFG intensity data from this system. An analysis based on the signs of the resulting response amplitudes is used to deduce the relative magnitude of the electric dipole and higher order interfacial terms. It is found that the buried interface is closer to satisfying the electric dipole approximation, consistent with smaller field gradients due to closer index matching between the organic thin film and substrate relative to air. The procedure outlined in this work allows for the difficult task of deducing a physical picture of average molecular orientation at the buried interface of a multilayer organic thin film system while including higher order effects.

  17. From Augustine of Hippo’s Memory Systems to Our Modern Taxonomy in Cognitive Psychology and Neuroscience of Memory: A 16-Century Nap of Intuition before Light of Evidence

    Directory of Open Access Journals (Sweden)

    Jean-Christophe Cassel

    2012-12-01

    Full Text Available Over the last half century, neuropsychologists, cognitive psychologists and cognitive neuroscientists interested in human memory have accumulated evidence showing that there is not one general memory function but a variety of memory systems deserving distinct (but for an organism, complementary functional entities. The first attempts to organize memory systems within a taxonomic construct are often traced back to the French philosopher Maine de Biran (1766–1824, who, in his book first published in 1803, distinguished mechanical memory, sensitive memory and representative memory, without, however, providing any experimental evidence in support of his view. It turns out, however, that what might be regarded as the first elaborated taxonomic proposal is 14 centuries older and is due to Augustine of Hippo (354–430, also named St Augustine, who, in Book 10 of his Confessions, by means of an introspective process that did not aim at organizing memory systems, nevertheless distinguished and commented on sensible memory, intellectual memory, memory of memories, memory of feelings and passion, and memory of forgetting. These memories were envisaged as different and complementary instances. In the current study, after a short biographical synopsis of St Augustine, we provide an outline of the philosopher’s contribution, both in terms of questions and answers, and focus on how this contribution almost perfectly fits with several viewpoints of modern psychology and neuroscience of memory about human memory functions, including the notion that episodic autobiographical memory stores events of our personal history in their what, where and when dimensions, and from there enables our mental time travel. It is not at all meant that St Augustine’s elaboration was the basis for the modern taxonomy, but just that the similarity is striking, and that the architecture of our current viewpoints about memory systems might have preexisted as an outstanding

  18. Evidence in the learning organization

    Directory of Open Access Journals (Sweden)

    Umscheid Craig A

    2009-03-01

    Full Text Available Abstract Background Organizational leaders in business and medicine have been experiencing a similar dilemma: how to ensure that their organizational members are adopting work innovations in a timely fashion. Organizational leaders in healthcare have attempted to resolve this dilemma by offering specific solutions, such as evidence-based medicine (EBM, but organizations are still not systematically adopting evidence-based practice innovations as rapidly as expected by policy-makers (the knowing-doing gap problem. Some business leaders have adopted a systems-based perspective, called the learning organization (LO, to address a similar dilemma. Three years ago, the Society of General Internal Medicine's Evidence-based Medicine Task Force began an inquiry to integrate the EBM and LO concepts into one model to address the knowing-doing gap problem. Methods During the model development process, the authors searched several databases for relevant LO frameworks and their related concepts by using a broad search strategy. To identify the key LO frameworks and consolidate them into one model, the authors used consensus-based decision-making and a narrative thematic synthesis guided by several qualitative criteria. The authors subjected the model to external, independent review and improved upon its design with this feedback. Results The authors found seven LO frameworks particularly relevant to evidence-based practice innovations in organizations. The authors describe their interpretations of these frameworks for healthcare organizations, the process they used to integrate the LO frameworks with EBM principles, and the resulting Evidence in the Learning Organization (ELO model. They also provide a health organization scenario to illustrate ELO concepts in application. Conclusion The authors intend, by sharing the LO frameworks and the ELO model, to help organizations identify their capacities to learn and share knowledge about evidence-based practice

  19. Groundwater dynamics in the complex aquifer system of Gidabo River Basin, southern Main Ethiopian Rift: Evidences from hydrochemistry and isotope hydrology

    Science.gov (United States)

    Degu, Abraham; Birk, Steffen; Dietzel, Martin; Winkler, Gerfried; Moggessie, Aberra

    2014-05-01

    Located in the tectonically active Main Ethiopian Rift system, the Gidabo River Basin in Ethiopia has a complex hydrogeological setting. The strong physiographic variation from highland to rift floor, variability in volcanic structures and disruption of lithologies by cross-cutting faults contribute for their complex nature of hydrogeology in the area. Until now, the groundwater dynamics and the impact of the tectonic setting on groundwater flow in this region are not well understood, though the local population heavily depends on groundwater as the major water supply. A combined approach based on hydrochemical and isotopic data was applied to investigate the regional flow dynamics of the groundwater and the impact of tectonic setting. Groundwater evolves from slightly mineralized Ca-Mg-HCO3 on the highland to highly mineralized Na-HCO3 dominating type in the deep rift floor aquifers. δ18O and δD composition of groundwater show a general progressive enrichment from the highland to the rift floor, except in thermal and deep rift floor aquifers. Relatively the thermal and deep rift floor aquifers are depleted and show similar signature to the groundwaters of highland, indicating groundwater inflow from the highland. Correspondingly, rising HCO3 and increasingly enriched signatures of δ 13C points to hydrochemical evolution of DIC and diffuse influx of mantle CO2 into the groundwater system. Thermal springs gushing out along some of the fault zones, specifically in the vicinity of Dilla town, display clear influence of mantle CO2 and are an indication of the role of the faults acting as a conduit for deep circulating thermal water to the surface. By considering the known geological structures of the rift, hydrochemical and isotopic data we propose a conceptual groundwater flow model by characterizing flow paths to the main rift axis. The connection between groundwater flow and the impact of faults make this model applicable to other active rift systems with similar

  20. Do postures of distal effectors affect the control of actions of other distal effectors? Evidence for a system of interactions between hand and mouth.

    Directory of Open Access Journals (Sweden)

    Maurizio Gentilucci

    Full Text Available The present study aimed at determining whether, in healthy humans, postures assumed by distal effectors affect the control of the successive grasp executed with other distal effectors. In experiments 1 and 2, participants reached different objects with their head and grasped them with their mouth, after assuming different hand postures. The postures could be implicitly associated with interactions with large or small objects. The kinematics of lip shaping during grasp varied congruently with the hand posture, i.e. it was larger or smaller when it could be associated with the grasping of large or small objects, respectively. In experiments 3 and 4, participants reached and grasped different objects with their hand, after assuming the postures of mouth aperture or closure (experiment 3 and the postures of toe extension or flexion (experiment 4. The mouth postures affected the kinematics of finger shaping during grasp, that is larger finger shaping corresponded with opened mouth and smaller finger shaping with closed mouth. In contrast, the foot postures did not influence the hand grasp kinematics. Finally, in experiment 5 participants reached-grasped different objects with their hand while pronouncing opened and closed vowels, as verified by the analysis of their vocal spectra. Open and closed vowels induced larger and smaller finger shaping, respectively. In all experiments postures of the distal effectors induced no effect, or only unspecific effects on the kinematics of the reach proximal/axial component. The data from the present study support the hypothesis that there exists a system involved in establishing interactions between movements and postures of hand and mouth. This system might have been used to transfer a repertoire of hand gestures to mouth articulation postures during language evolution and, in modern humans, it may have evolved a system controlling the interactions existing between speech and gestures.

  1. Response of a dryland fluvial system to climate-tectonic perturbations during the Late Quaternary: Evidence from Rukmawati River basin, Kachchh, western India

    Science.gov (United States)

    Das, Archana; Bhattacharya, Falguni; Rastogi, B. K.; Chauhan, Gaurav; Ngangom, Mamata; Thakkar, M. G.

    2016-08-01

    Dryland rivers, dominated by short-lived, localised and highly variable flow due to discrete precipitation events, have characteristic preservation potential, which serves as suitable archives towards understanding the climate-tectonic coupling. In the present study, we have investigated the fluvial records of a major, southerly-draining river - the Rukmawati River in the dryland terrain of southern Kachchh, in western India. The sediment records along the bedrock rivers of Kachchh register imprints of the Indian summer monsoon (ISM), which is the major source of moisture to the fluvial system in western India. The Rukmawati River originates from the Katrol Hill Range in the north and flows towards the south, into the Gulf of Kachchh. The field stratigraphy, sedimentology, along with the optical chronology suggests that a braided-meandering system existed during 37 ka period due to an overall strengthened monsoon. A gradual decline in the monsoon strength with fluctuation facilitated the development of a braided channel system between 20 and 15 ka. A renewed phase of strengthened monsoon with seasonality after around 15 ka which persisted until around 11 ka, is implicated in the development of floodplain sequences. Two zones of relatively high bedrock uplift are identified based on the geomorphometry and morphology of the fluvial landform. These zones are located in the vicinity of the North Katrol Hill Fault (NKHF) and South Katrol Hill Fault (SKHF). Geomorphic expression of high bedrock uplift is manifested by the development of beveled bedrock prior to or around 20 ka during weak monsoon. The study suggests that the terrain in the vicinity of NKHF and SKHF is uplifting at around 0.8 and >0.3 mm/a, respectively. Simultaneously, the incision in the Rukmawati River basin, post 11 ka, is ascribed to have occurred due to lowered sea level during the LGM and early Holocene period.

  2. IL-17A levels in systemic lupus erythematosus associated with inflammatory markers and lower rates of malignancy and heart damage: Evidence for a dual role

    Science.gov (United States)

    Raymond, Warren; Ostli-Eilertsen, Gro; Griffiths, Sheynae; Nossent, Johannes

    2017-01-01

    Objective The interleukin 17 (IL-17) cytokine family is involved in a number of chronic inflammatory diseases. In spite of contradictory findings and a lack of causality in clinical studies, IL-17 inhibition for systemic lupus erythematosus (SLE) has regained attention as a potential therapeutic pathway, after demonstrating disease-modifying capabilities in ankylosing spondylitis. We investigated the clinical associations of interleukin 17 A (IL-17A) in patients with SLE. Material and Methods A cross-sectional study was performed involving SLE patients (n=102; age: 49 years; 86% female) recruited from a regional registry. IL-17A levels were determined by immunoassay, disease activity by Systemic Lupus Erythematosus Disease Activity Index-2K (SLEDAI-2K), and cumulative damage by Systemic Lupus International Collaborative Clinics Damage Index (SDI) scores. Non-parametric techniques were used to examine the association between IL-17A and disease activity and autoantibody profiles were compared with healthy controls (n=31): principal component analysis (PCA) was used to determine the interplay of immune cells across disease states and damage development in SLE patients. Results SLE patients had higher IgG levels, lower T-cell and B-cell counts, but median IL-17A levels did not differ from the controls (28.4 vs. 28.4 pg/mL, p=0.9). In SLE patients, IL-17A did not correlate with SLEDAI-2K or SDI, but was inversely related with age (correlation coefficients, Rs.=–0.29, phs-CRP) levels (Rs.=0.28, p<0.05), proteinuria (Rs.=0.64, p<0.05), and pre-albumin (Rs.=–0.22, p<0.05). Longitudinal data showed only modest fluctuation in IL-17A levels, independent of SLEDAI-2K. Conclusion These results suggest that IL-17A, while participating in inflammation, may also serve a protective purpose in SLE patients. PMID:28293450

  3. Response of a dryland fluvial system to climate–tectonic perturbations during the Late Quaternary: Evidence from Rukmawati River basin, Kachchh, western India

    Indian Academy of Sciences (India)

    Archana Das; Falguni Bhattacharya; B K Rastogi; Gaurav Chauhan; Mamata Ngangom; M G Thakkar

    2016-08-01

    Dryland rivers, dominated by short-lived, localised and highly variable flow due to discrete precipitation events, have characteristic preservation potential, which serves as suitable archives towards understanding the climate–tectonic coupling. In the present study, we have investigated the fluvial records of a major, southerly-draining river – the Rukmawati River in the dryland terrain of southern Kachchh, in western India. The sediment records along the bedrock rivers of Kachchh register imprints of the Indian summer monsoon (ISM), which is the major source of moisture to the fluvial system in western India. The Rukmawati River originates from the Katrol Hill Range in the north and flows towards the south, into the Gulf of Kachchh. The field stratigraphy, sedimentology, along with the optical chronology suggeststhat a braided-meandering system existed during 37 ka period due to an overall strengthened monsoon. A gradual decline in the monsoon strength with fluctuation facilitated the development of a braided channel system between 20 and 15 ka. A renewed phase of strengthened monsoon with seasonality after around 15 ka which persisted until around 11 ka, is implicated in the development of floodplain sequences. Two zones of relatively high bedrock uplift are identified based on the geomorphometry and morphology of the fluvial landform. These zones are located in the vicinity of the North Katrol Hill Fault (NKHF) and South Katrol Hill Fault (SKHF). Geomorphic expression of high bedrock uplift is manifested by the development of beveled bedrock prior to or around 20 ka during weak monsoon. The study suggests that the terrain in the vicinity of NKHF and SKHF is uplifting at around 0.8 and >0.3 mm/a, respectively. Simultaneously, the incision in the Rukmawati River basin, post 11 ka, is ascribed to have occurred due to lowered sea level during the LGM and early Holocene period.

  4. Bridging the osteoarthritis treatment gap with the KineSpring Knee Implant System: early evidence in 100 patients with 1-year minimum follow-up

    Directory of Open Access Journals (Sweden)

    London NJ

    2013-09-01

    Full Text Available Nicholas J London,1 Jon Smith,2 Larry E Miller,3,4 Jon E Block4 1Department of Orthopaedic Surgery, Harrogate District Foundation Trust, Harrogate, UK; 2The Mid Yorkshire Hospitals NHS Trust, Yorkshire, UK; 3Miller Scientific Consulting, Arden, NC, USA; 4The Jon Block Group, San Francisco, CA, USA Abstract: Almost 4 million Americans are within the knee osteoarthritis (OA treatment gap, the period from unsuccessful exhaustion of conservative treatment to major surgical intervention. New treatment alternatives for symptomatic knee OA are greatly needed. The purpose of this report was to assess outcomes of a joint-unloading implant (KineSpring® Knee Implant System in patients with symptomatic medial knee OA. A total of 100 patients enrolled in three clinical trials were treated with the KineSpring System and followed for a minimum of 1 year. All devices were successfully implanted and activated, with no operative complications. Knee pain severity improved 60% (P < 0.001 at 1 year, with 76% of patients reporting a minimum 30% improvement in pain severity. All Western Ontario and McMaster Universities Arthritis Index (WOMAC subscores significantly improved at 1 year, with a 56% improvement in pain, 57% improvement in function, and a 39% improvement in stiffness (all P < 0.001. The percentage of patients experiencing a minimum 20% improvement in WOMAC subscores was 74% for pain, 83% for function, and 67% for stiffness. During follow-up, six (6% patients required additional surgery, including four total knee arthroplasties and two high tibial osteotomies. The KineSpring System effectively bridges the treatment gap between failed conservative care and surgical joint-modifying procedures. Keywords: implant, KineSpring, knee, medial, osteoarthritis, unloading

  5. New boron isotopic evidence for sedimentary and magmatic fluid influence in the shallow hydrothermal vent system of Milos Island (Aegean Sea, Greece)

    Science.gov (United States)

    Wu, Shein-Fu; You, Chen-Feng; Lin, Yen-Po; Valsami-Jones, Eugenia; Baltatzis, Emmanuel

    2016-01-01

    Magmatic sources may contribute a significant amount of volatiles in geothermal springs; however, their role is poorly understood in submarine hydrothermal systems worldwide. In this study, new results of B and δ11B in 41 hydrothermal vent waters collected from the shallow hydrothermal system of Milos island in the Aegean Sea were combined with previously published data from other tectonic settings and laboratory experiments to quantify the effects of phase separation, fluid/sediment interaction and magmatic contribution. Two Cl-extreme solutions were identified, high-Cl waters (Cl as high as 2000 mM) and low-Cl waters (Cl < 80 mM). Both sets of waters were characterized by high B/Cl (~ 1.2-5.3 × 10- 3 mol/mol) and extremely low δ11B (1.4-6.3‰), except for the waters with Mg content of near the seawater value and δ11B = 10.3-17.4‰. These high-Cl waters with high B/Cl and low δ11B plot close to the vent waters in sediment-hosted hydrothermal system (i.e., Okinawa Trough) or fumarole condensates from on-land volcanoes, implying B addition from sediment or magmatic fluids plays an important role. This is in agreement with fluid/sediment interactions resulting in the observed B and δ11B, as well as previously reported Br/I/Cl ratios, supporting a scenario of slab-derived fluid addition with elevated B, 11B-rich, and low Br/Cl and I/Cl, which is derived from the dehydration of subducted-sediments. The slab fluid becomes subsequently mixed with the parent magma of Milos. The deep brine reservoir is partially affected by injections of magmatic fluid/gases during degassing. The results presented here are crucial for deciphering the evolution of the brine reservoirs involved in phase separation, fluid/sediment interaction and magmatic contribution in the deep reaction zone of the Milos hydrothermal system; they also have implications in the understanding of the formation of metallic vein mineralization.

  6. Explicating an evidence-based, theoretically informed, mobile technology-based system to improve outcomes for people in recovery for alcohol dependence.

    Science.gov (United States)

    Gustafson, David H; Shaw, Bret R; Isham, Andrew; Baker, Timothy; Boyle, Michael G; Levy, Michael

    2011-01-01

    Post-treatment relapse to uncontrolled alcohol use is common. Currently available communication technology can use existing models for relapse prevention to cost-effectively improve long-term relapse prevention. This paper describes: (1) research-based elements of alcohol consumption-related relapse prevention and how they can be encompassed in self-determination theory (SDT) and Marlatt's cognitive behavioral relapse prevention model, (2) how technology could help address the needs of people seeking recovery, (3) a technology-based prototype, organized around sexual transmitted disease and Marlatt's model, and (4) how we are testing a system based on the ideas in this article and related ethical and operational considerations.

  7. What is Evidence? (editorial

    Directory of Open Access Journals (Sweden)

    Denise Koufogiannakis

    2011-06-01

    Full Text Available Lately, I have been pondering what we really mean when we say “evidence based practice”? In LIS, we all know the definitions that have been proposed (Booth 2000, Eldredge 2000, Crumley and Koufogiannakis 2002, and which have not ever really been challenged. But have we ever said explicitly what qualifies as evidence in this model? The underlying assumption seems to be that evidence is research, hence, we are really talking about research-based practice, but we don’t actually use that term.Higgs and Jones (2000 note that evidence is “knowledge derived from a variety of sources that has been subjected to testing and has found to be credible.” The Oxford English Dictionary states that evidence is “something serving as a proof” (OED, 2011. Neither of these definitions of evidence notes that evidence equals research; research is only one form of evidence. It certainly isn’t the only form of evidence – so what, then, constitutes evidence?Rycroff-Malone et al. (2004 state that that in order for evidence based practice to create a broader evidence base in nursing, “the external, scientific and the internal, intuitive” need to be brought together. The external, scientific is what evidence based practice has been focused on, in the form of scientific research, but Rycroff-Malone et al. note that other elements such as clinical experience, patient experience, and information from the local context also need to be considered.In library and information practice, what are the other forms of evidence we need to consider? I propose that while research evidence is of high importance to our profession and knowledge, LIS practitioners need to first of all consider local evidence. Local evidence is found in our working environment and specific to the context in which we carry out our work. It includes such things as our experiences with patrons in particular contexts, and what we observe to work in such situations, assessment of programs

  8. Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system

    Directory of Open Access Journals (Sweden)

    M.C.O. Citó

    2015-01-01

    Full Text Available Hoodia gordonii is a plant species used traditionally in southern Africa to suppress appetite. Recently, it has been associated with a significant increase in blood pressure and pulse rate in women, suggesting sympathomimetic activity. The present study investigated the possible antidepressant-like effects of acute and repeated (15 days administration of H. gordonii extract (25 and 50 mg/kg, po to mice exposed to a forced swimming test (FST. Neurochemical analysis of brain monoamines was also carried out to determine the involvement of the monoaminergic system on these effects. Acute administration of H. gordonii decreased the immobility of mice in the FST without accompanying changes in general activity in the open-field test during acute treatment, suggesting an antidepressant-like effect. The anti-immobility effect of H. gordonii was prevented by pretreatment of mice with PCPA [an inhibitor of serotonin (5-HT synthesis], NAN-190 (a 5-HT1A antagonist, ritanserin (a 5-HT2A/2C antagonist, ondansetron (a 5-HT3A antagonist, prazosin (an α1-adrenoceptor antagonist, SCH23390 (a D1 receptor antagonist, yohimbine (an α2-adrenoceptor antagonist, and sulpiride (a D2 receptor antagonist. A significant increase in 5-HT levels in the striatum was detected after acute administration, while 5-HT, norepinephrine and dopamine were significantly elevated after chronic treatment. Results indicated that H. gordonii possesses antidepressant-like activity in the FST by altering the dopaminergic, serotonergic, and noradrenergic systems.

  9. Personality systems interactions theory and the theory of planned behaviour: evidence that self-regulatory volitional components enhance enactment of studying behaviour.

    Science.gov (United States)

    Orbell, Sheina

    2003-03-01

    The role of volitional components specified by personality systems interactions theory in enhancing behavioural prediction was examined in a longitudinal investigation of students' studying. Participants completed measures specified by the theory of planned behaviour and questionnaire measures of 'conscious attention control', 'implicit attention control' and 'self-determination' from the volitional components inventory. Behaviour was assessed 2 weeks later. Regression analyses showed that volitional components increased variance explained in behaviour by 10-18%, after taking into account strength of motivation to study assessed by attitude, subjective norm, perceived behavioural control and intention from the theory of planned behaviour. Moreover, consistent with elements of personality systems interactions theory, moderator effects were obtained. Participants who reported self-determination, conscious attention control and implicit attention control were more likely to enact their intentions. Volitional components were also associated with increased studying among participants who perceived a low subjective norm for studying. Volitional components improved prediction of studying after accounting for past behaviour in the regression models.

  10. A powerful double radio relic system discovered in PSZ1 G108.18-11.53: evidence for a shock with non-uniform Mach number?

    CERN Document Server

    de Gasperin, F; van Weeren, R J; Dawson, W A; Golovich, N; Wittman, D; Bonafede, A; Bruggen, M

    2015-01-01

    Diffuse radio emission in the form of radio halos and relics has been found in a number of merging galaxy clusters. These structures indicate that shock and turbulence associated with the merger accelerate electrons to relativistic energies. We report the discovery of a radio relic + radio halo system in PSZ1 G108.18-11.53 (z=0.335). This cluster hosts the second most powerful double radio relic system ever discovered. We observed PSZ1 G108.18-11.53 with the Giant Meterwave Radio Telescope (GMRT) and the Westerbork Synthesis Radio Telescope (WSRT). We obtained radio maps at 147, 323, 607 and 1380 MHz. We also observed the cluster with the Keck telescope, obtaining the spectroscopic redshift for 42 cluster members. From the injection index we obtained the Mach number of the shocks generating the two radio relics. For the southern shock we found M = 2.33^{+0.19}_{-0.26}, while the northern shock Mach number goes from M = 2.20^{+0.07}_{-0.14} in the north part down to M = 2.00^{+0.03}_{-0.08} in the southern reg...

  11. Anti-depressant-like effect of kaempferitrin isolated from Justicia spicigera Schltdl (Acanthaceae) in two behavior models in mice: evidence for the involvement of the serotonergic system.

    Science.gov (United States)

    Cassani, Julia; Dorantes-Barrón, Ana María; Novales, Lilian Mayagoitia; Real, Guadalupe Alva; Estrada-Reyes, Rosa

    2014-12-19

    We evaluated the antidepressant-like effect of kaempferitrin (Km) isolated from the plant Justicia spicigera (Asteraceae), which is used in traditional medicine for relieving emotional disorders, such as "la tristeza" (sadness or dysthymia) and "el humor" (mood changes). The actions of Km were evaluated in a forced swimming test (FST) and a suspension tail test (TST) in mice. We explored the involvement of the serotonergic system and the hypothalamic-hypophysis-adrenal axis (HPA) in the antidepressant-like effect of Km. To evaluate nonspecific effects of Km on general activity, the open field test (OFT) was performed. Km at 5, 10, and 20 mg/kg induced an antidepressant-like effect. Sub-effective dose of Km (1 mg/kg) produced a synergistic effect with imipramine (6.25 mg/kg) and fluoxetine (10 mg/kg) but not with desipramine (3.12 mg/kg). Pretreatment with p-chlorophenylalanine methyl ester (PCPA), a serotonin synthesis inhibitor, N-{2-(4-(2-methoxyphenyl)-1-piperazinyl}-N-(2-pyridinyl)cyclohexecarboxamide (WAY-100635), a selective 5-HT1A receptor antagonist, and 8OH-DPAT, a selective 5-HT1A agonist, but not pindolol (10 mg/kg) blocked the anti- immobility effect induced by Km. Taken together, these results indicate that the antidepressant-like effect of Km is related to the serotonergic system, principally 5-HT1A. This effect was not related to changes in locomotor activity.

  12. Anti-Depressant-Like Effect of Kaempferitrin Isolated from Justicia spicigera Schltdl (Acanthaceae in Two Behavior Models in Mice: Evidence for the Involvement of the Serotonergic System

    Directory of Open Access Journals (Sweden)

    Julia Cassani

    2014-12-01

    Full Text Available We evaluated the antidepressant-like effect of kaempferitrin (Km isolated from the plant Justicia spicigera (Asteraceae, which is used in traditional medicine for relieving emotional disorders, such as “la tristeza” (sadness or dysthymia and “el humor” (mood changes. The actions of Km were evaluated in a forced swimming test (FST and a suspension tail test (TST in mice. We explored the involvement of the serotonergic system and the hypothalamic-hypophysis-adrenal axis (HPA in the antidepressant-like effect of Km. To evaluate nonspecific effects of Km on general activity, the open field test (OFT was performed. Km at 5, 10, and 20 mg/kg induced an antidepressant-like effect. Sub-effective dose of Km (1 mg/kg produced a synergistic effect with imipramine (6.25 mg/kg and fluoxetine (10 mg/kg but not with desipramine (3.12 mg/kg. Pretreatment with p-chlorophenylalanine methyl ester (PCPA, a serotonin synthesis inhibitor, N-{2-(4-(2-methoxyphenyl-1-piperazinyl}-N-(2-pyridinylcyclohexecarboxamide (WAY-100635, a selective 5-HT1A receptor antagonist, and 8OH-DPAT, a selective 5-HT1A agonist, but not pindolol (10 mg/kg blocked the anti- immobility effect induced by Km. Taken together, these results indicate that the antidepressant-like effect of Km is related to the serotonergic system, principally 5-HT1A. This effect was not related to changes in locomotor activity.

  13. Evidence for the participation of the stimulated sympathetic nervous system in the regulation of carnitine blood levels of soccer players during a game.

    Science.gov (United States)

    Schulpis, Kleopatra H; Parthimos, Theodore; Papakonstantinou, Evangelos D; Tsakiris, Theodore; Parthimos, Nickolaos; Mentis, Alexios-Fotios A; Tsakiris, Stylianos

    2009-08-01

    Catecholamines and carnitine blood levels are closely implicated with training. The aim of the study was to investigate the effect of sympathetic nervous system stimulation on carnitine and its fraction levels during training. Blood was obtained from 14 soccer players pregame, at intermission, and postgame. Catecholamines were measured with high-performance liquid chromatography methods; muscle enzymes creatine kinase and lactate dehydrogenase as well as lactate, pyruvate, and total antioxidant status with commercial kits; and carnitine and fraction levels with tandem mass spectrometry. Total antioxidant status (2.97 +/- 0.13 vs 0.96 +/- 0.10 mmol/L, P r = -0.51, P r = 0.58, P r = 0.49, P < .01). The significant positive correlation of adrenaline levels with total acylcarnitine and total long-chain acylcarnitine blood levels in athletes as well as the inverse correlation with free carnitine levels may indicate participation of the stimulated sympathetic nervous system in the regulation of some carnitine fraction levels during exercise.

  14. Biotic interactions as a structuring force in soil communities: evidence from the micro-arthropods of an Antarctic moss model system.

    Science.gov (United States)

    Caruso, Tancredi; Trokhymets, Vladlen; Bargagli, Roberto; Convey, Peter

    2013-06-01

    Current meta-community theories postulate that the structure of local communities depends on dispersal, environmental filtering, and biotic interactions. However, disentangling the relative effects of these factors in the field and for diverse assemblages is a major challenge. A solution is to address natural but simple communities (i.e. with low numbers of species in few trophic levels), wherein one of these factors is predominan