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Sample records for apres chirurgie bariatrique

  1. Cinétique de la troponine Ic et valeurs seuils pour le diagnostic d'infarctus du myocarde après chirurgie cardiaque sous circulation extracorporelle

    Science.gov (United States)

    Kallel, Samy; Jarraya, Anwar; Ellouze, Maged; Frikha, Imed; Karoui, Abbdelhamid

    2012-01-01

    Introduction L'objectif de ce travail était d’étudier la cinétique de la Troponine Ic (TnIc) après chirurgie cardiaque sous circulation extracorporelle (CEC) et établir des valeurs seuils de TnIc pour le diagnostic d'infarctus du myocarde (IDM) post opératoire. Il s'agissait d'une étude prospective type cohorte observationnelle. Méthodes Nous avons inclus 37 patients âgés de plus de 18 ans proposés pour chirurgie valvulaire ou pontage aorto coronarien sous CEC. Nous avons suivi la cinétique de TnIc par des dosages immunoenzymatique sur mini-vidas® avant et après la CEC, à H4 et H12 postopératoire puis tous les jours les 4 premiers jours. Le cutoff pour le diagnostic d'IDM post opératoire a été défini comme la valeur moyenne de troponine + deux déviations standards des patients indemnes de complications cardiaques. Résultats Les valeurs de TnIc en préopératoire étaient toutes inférieures au seuil de détection de la méthode de dosage (<0,01µg/l). Les valeurs de TnIc augmentent en postopératoire immédiat pour atteindre un maximum à H4 puis diminuent progressivement pour se normaliser après 4 à 5 jours. Les valeurs seuils ont été déterminées pour H0, H4,H12, H24, H48, H72, H96 et ont été respectivement 1.36, 2.58, 3.1, 3.23, 2.13, 1.53, 1.17 pour la chirurgie coronaire et 3.75, 5.39, 4.22, 3.41, 1.65, 1.3 1.19 pour la chirurgie valvulaire. Conclusion La connaissance de la cinétique de TnIc lors de chirurgie cardiaque non compliquée et la fixation de valeur seuil ou Cutoff permet aux cliniciens de distinguer entre dommage myocardique secondaire à la chirurgie et IDM. PMID:23396754

  2. Cinétique de la troponine Ic et valeurs seuils pour le diagnostic d'infarctus du myocarde après chirurgie cardiaque sous circulation extracorporelle

    OpenAIRE

    Kallel, Samy; Jarraya, Anwar; Ellouze, Maged; Frikha, Imed; Karoui, Abbdelhamid

    2012-01-01

    Introduction L'objectif de ce travail était d’étudier la cinétique de la Troponine Ic (TnIc) après chirurgie cardiaque sous circulation extracorporelle (CEC) et établir des valeurs seuils de TnIc pour le diagnostic d'infarctus du myocarde (IDM) post opératoire. Il s'agissait d'une étude prospective type cohorte observationnelle. Méthodes Nous avons inclus 37 patients âgés de plus de 18 ans proposés pour chirurgie valvulaire ou pontage aorto coronarien sous CEC. Nous avons suivi la cinétique d...

  3. Le sondage urinaire est-il nécessaire après chirurgie colique en Fast-Track avec une analgésie péridurale thoracique ? Une étude prospective

    OpenAIRE

    Delecluse, Léonard; Forget, Patrice; Remue, Christophe; Veevaete, Laurent; Lois, Fernande; De Kock, Marc; Kartheuser, Alex; Le sondage urinaire est-il nécessaire après chirurgie colique en Fast-Track avec une analgésie péridurale thoracique? Une étude prospective

    2010-01-01

    Introduction Les patients se plaignent fréquemment de symptômes urinaires causés par le sondage. Dans la chirurgie avec réhabilitation rapide (Fast-Track), le retrait de la sonde urinaire en fin de procédure chirurgicale pourrait être associé à une faible morbidité, un faible risque de rétention urinaire postopératoire (RUPO), une mobilisation plus facile et un confort accru. Patients et Méthodes Avec l’accord du Comité d’Ethique, les patients programmés pour une résection colique av...

  4. Pronostic visuel et évolution réfractive après chirurgie de la cataracte congénitale avec implantation primaire: étude d'une série de 108 cas

    Science.gov (United States)

    Hafidi, Zouheir; Ibrahimy, Wafaa; Ahid, Samir; Handor, Hanan; Ouafae Cherkaoui, Lalla; Bencherif, Zahid; Laghmari, Mina; Ouazzanni, Btissam; Boutimzine, Noureddine; Daoudi, Rajae

    2013-01-01

    La cataracte congénitale constitue la cause la plus fréquente de cécité évitable chez les enfants. Le but de cette étude est d’évaluer le pronostic réfractif et fonctionnel, des enfants opérés de cataracte congénitale avec implantation. Il s'agit d'une étude rétrospective de 108 enfants, dont 85 cataractes bilatérales, 23 unilatérales opérés entre 2007 et 2011. La réfraction a été mesurée à 1 mois, 3 mois, 6 mois, 1 an, 2 ans, 3 ans et/ou 4 ans en post-opératoire. La meilleure acuité visuelle corrigée, ainsi que l'incidence des complications post-opératoires ont été analysé. L’âge moyen de la chirurgie était de 25 mois avec une durée moyenne de suivi de 3,17 ans. Les complications retrouvées étaient l'inflammation, la prolifération secondaire, et le glaucome. L'acuité visuelle (AV) moyenne corrigée finale était de 5,75/10e pour les formes bilatérales, et de 4,16/10e pour les unilatérales (p = 0,001). Les facteurs de mauvais pronostic retrouvés étaient l’âge tardif de la chirurgie, la densité de la cataracte et la survenue de complications (p = 0,001). L'incidence des complications post-opératoires était significativement plus élevé chez les enfants opérés à un jeune âge (p = 0,001). Les facteurs de mauvais pronostic visuel chez les enfants opérés pour cataracte congénitale avec implantation, sont représentés par le caractère unilatéral de la cataracte, l’âge tardif de la chirurgie, la densité de la cataracte et la survenue de complications post opératoires. PMID:24672622

  5. Chirurgie in die Grieks-Romeinse era

    Directory of Open Access Journals (Sweden)

    François P. Retief

    2006-09-01

    Full Text Available In die Grieks-Romeinse era het mediese behandeling kenmerkend uit drie elemente bestaan, naamlik regimen (dieet en gesonde leefwyse, geneesmiddels en chirurgie – laasgenoemde alleen toegepas indien regimen en geneesmiddels onsuksesvol was. Bewyse van primitiewe chirurgie dateer terug na die Bronstydperk, en in Homerus se eposse is heelwat vermelding van die chirurgiese hantering van oorlogswonde, met tussenkoms van die gode. Met die koms van empiriese geneeskunde in die 5de eeu v.C. het chirurgie in die Hippokratiese Corpus prominent gefigureer met beduidende bydraes in veral die ortopediese veld en hoofbeserings. Uitbouing van anatomiese en fisiologiese kennis, gebaseer op disseksie van menslike kadawers in Alexandrië vanaf die laat 4de eeu v.C., het chirurgie ’n hupstoot gegee. Teen die Romeinse era vanaf die 2de eeu v.C. het snykundetegnieke (en -instrumente beduidend verbeter, maar is steeds oorwegend deur Griekse geneeshere beoefen. Van geneeshere is steeds verwag om al drie bovermelde terapeutiese modaliteite te bemeester, maar chirurgie het meer aansien verwerf en daar is al meer in onderafdelings van chirurgie soos oogheelkunde, vrouesiektes en verloskunde, blaaskwale en mond- en keelsnykunde gespesialiseer. Militêre geneeskunde was in die Romeinse Ryk ’n belangrike aktiwiteit, en het veral traumachirurgie uitgebou. Betreding van die buik- en toraksholtes was nie meer noodwendig fataal nie, en veeartsenykunde het tot stand gekom. Die eerste beduidende chirurgiehandboek ná die Hippokratiese Corpus is in die 1ste eeu n.C. deur Celsus opgestel. Vanaf die 3de eeu het die chirurgieberoep min vordering gemaak, die beroepstaal het mettertyd van Grieks na Latyn verander en kundigheid is later veral deur Islam-geneeshere na die Middeleeue en later oorgedra.

  6. La chirurgie du diaphragme sous aortique

    Science.gov (United States)

    Moutakiallah, Younes; Maaroufi, Ilham; Aithoussa, Mahdi; Bamous, Mehdi; Abdou, Abdessamad; Atmani, Noureddine; Hatim, Abdedaïm; Amahzoune, Brahim; Bekkali, Youssef El; Boulahya, Abdelatif

    2016-01-01

    Le diaphragme sous aortique se caractérise par une certaine latence clinique et une faible morbi-mortalité. La chirurgie reste le traitement de choix malgré un réel risque de récurrence à long terme. Nous rapportons 18 patients opérés entre Avril 1994 et Mars 2011 pour diaphragme sous aortique d’âge moyen de 18,1±9,7 ans avec 11 patients de sexe masculin. Le diaphragme était de nature fibreuse chez 13 patients et fibro-musculaire chez 5 patients. Tous les patients ont été opérés par résection de diaphragme associée à une myectomie, une plastie aortique, une fermeture de communication interventriculaire et une ligature de canal artériel perméable respectivement chez 3, 3, 2 et 2 patients. La Mortalité opératoire était nulle et sans aucun cas de trouble de conduction postopératoire. Le suivi a duré en moyenne 44,3±36,8 mois sans aucun décès tardif. Deux patients ont présenté une récidive de diaphragme qui a nécessité une réopération avec bonne évolution. La tendance actuelle dans la chirurgie du diaphragme se fait vers des interventions précoces et des résections plus extensives. Cependant, le risque de récidive impose une surveillance échographique systématique et rapprochée. PMID:27516830

  7. Stenosen bei Morbus Crohn: Endoskopie vs. Chirurgie

    Directory of Open Access Journals (Sweden)

    Bachleitner-Hofmann T

    2012-01-01

    Full Text Available Etwa 1/3 aller Patienten mit Morbus Crohn entwickelt im Krankheitsverlauf Fibrostenosen mit Symptomen der intestinalen Obstruktion. Gemäß dem Verteilungsmuster der Erkrankung kommen Fibrostenosen im gesamten Intestinaltrakt vor, wenngleich sie am häufigsten im terminalen Ileum, Kolon sowie im Bereich ileokolonischer Anastomosen auftreten. Als Behandlungsoptionen stehen die chirurgische Resektion, chirurgische Strikturplastik-Techniken sowie die endoskopische Ballondilatation zur Verfügung. Bei langen bzw. komplizierten Stenosen (mit Fistel- oder Abszessbildung ist die chirurgische Resektion Therapie der Wahl. Die Resektion sollte so sparsam wie möglich erfolgen, um den Verlust intestinaler Resorptionsfläche zu minimieren. Strikturplastik-Techniken ermöglichen den kompletten Verzicht auf eine Darmresektion, was insbesondere bei Patienten mit multiplen Stenosen von Vorteil ist. Bei kurzen, unkomplizierten und endoskopisch erreichbaren Stenosen ist die endoskopische Ballondilatation eine vielversprechende Alternative zur Chirurgie mit guten Langzeitergebnissen und niedriger Komplikationsrate. Eine adäquate präoperative/ präinterventionelle Diagnostik ist von zentraler Bedeutung, um die jeweiligen Verfahren bestmöglich einsetzen zu können.

  8. Intraoperativer Ultraschall zur Registrierung von Knochenstrukturen in der navigierten Chirurgie

    OpenAIRE

    Brendel, Bernhard

    2005-01-01

    Im Rahmen dieser Arbeit wird untersucht, in wie weit intraoperativer Ultraschall zu einer minimal-invasiven und präzisen Registrierung von Knochenstrukturen in der navigierten Chirurgie geeignet ist. Für die genaue Positionsbestimmung von Knochenstrukturen mit Ultraschall ist die exakte Kalibrierung des Ultraschallwandlers notwendig. Es wird ein Kalibrierverfahren vorgestellt, das einen einfachen Aufbau mit hoher Präzision verbindet. Weiterhin wird ein Registrierungsverfahren b...

  9. Welche Bedeutung hat die Nachsorge nach bariatrischer Chirurgie?

    Directory of Open Access Journals (Sweden)

    Bender G

    2010-01-01

    Full Text Available In der Mehrzahl der adipösen Patienten, insbesondere bei morbider Adipositas mit einem Body-Mass-Index (BMI 40, ist ein konservativer Versuch der dauerhaften Gewichtsreduktion frustran. Hier hat sich die bariatrische Chirurgie als eine sehr wirksame Therapie für eine erhebliche und auch anhaltende Gewichtsreduktion erwiesen. Auch die metabolischen Komorbiditäten (arterielle Hypertonie, Dyslipidämie, Diabetes mellitus Typ 2 bzw. gestörte Glukosetoleranz zeigen eine rasche postoperative Verbesserung. Hier muss insbesondere der insulinpflichtige Patient engmaschig nachbetreut werden. Abhängig von der Art des Eingriffs (restriktive, malabsorptive oder kombinierte Verfahren treten postoperativ unterschiedlich häufig und variabel ausgeprägt Nährstoffdefizite auf, die frühzeitig erkannt und adäquat behandelt werden müssen. Eine generelle Multivitamingabe ist hierbei essenziell.

  10. Antibioprophylaxie dans les chirurgies gynécologiques et obstétricales propres et propres contaminées à l'Hôpital Général de Yaoundé, Cameroun

    Science.gov (United States)

    Ngowa, Jean Dupont Kemfang; Ngassam, Anny; Mbouopda, R Motzebo; Kasia, Jean Marie

    2014-01-01

    Introduction Il s'agira de déterminer l'incidence et les facteurs associés à l'infection post opératoire dans les chirurgies gynécologiques et obstétricales propres et propres contaminées. Méthodes Étude de cohorte prospective axée sur la surveillance de l'infection post opératoire chez les patientes opérées d'une chirurgie gynécologique ou obstétricale propre ou propre contaminée au Service de Gynécologie B de l'Hôpital Général de Yaoundé, après une antibioprophylaxie avec la cefazoline. La période d’étude de 18 mois s'est étalée de janvier 2012 à juin 2013. La surveillance des patientes opérées se poursuivait sur les 30 premiers jours post opératoires. Résultats Au total 211 patientes opérées d'une chirurgie gynécologique ou obstétricale propre ou propre contaminée ont été enrôlées dans cette étude. La moyenne d’âge des patientes était de 35,4 ±10 ans; les chirurgies propres contaminées représentaient 76,3% et les chirurgies propres 23,7%. Nous avons observé au total 06 (2,8%) cas d'infection post opératoire, dont 03 (1,4%) cas d'infection du site opératoire, 02 (0,95%) cas d'infection urinaire et 01(0,47%) cas d'infection pulmonaire. Les variables significativement associées à l'infection post opératoire étaient la durée de la chirurgie (durée moyenne: 126± 89min vs 82± 50 min; pinfection post opératoire global de 2,8% et d'infection du site opératoire de 1,4% vient renforcer les données de la littérature sur l'efficacité de l'antibioprophylaxie dans les chirurgies gynécologiques et obstétricales propres et propres contaminées en milieu africain. Cependant le respect des principes d'asepsie péri opératoire et une sélection précise de la classe de chirurgie devraient être de règle dans notre contexte. PMID:25667685

  11. DRGs: Auswirkungen auf Ökonomie und Struktur einer Krankenhausabteilung am Beispiel der Plastischen Chirurgie

    OpenAIRE

    Heinze, Ralf M.

    2010-01-01

    Mit der Einführung des DRG-Systems als Abrechnungsinstrument in deutschen Kliniken änderten sich die Abrechnungsmodalitäten grundlegend. Für die Abbildung des Fachbereiches Plastische Chirurgie im DRG-System lagen bisher noch keine ausführlichen Daten vor. In dieser Arbeit werden mit der Untersuchung und Auswertung von 236 Diagnosen und 1302 Prozeduren aus dem plastisch chirurgischen Fachgebiet und deren DRG-Einordnung erstmals umfassende Daten über die Abbildung der Plastischen Chirurgie im ...

  12. Surgery of malignant pancreatic tumors; Chirurgie maligner Pankreastumoren

    Energy Technology Data Exchange (ETDEWEB)

    Loos, M.; Friess, H.; Kleeff, J. [Klinikum rechts der Isar, Technische Universitaet Muenchen (Germany). Chirurgische Klinik und Poliklinik

    2009-02-15

    Ductal adenocarcinoma is the most common malignant tumor of the pancreas. Despite great efforts in basic and clinical pancreatic cancer research, the prognosis remains poor with an overall 5-year survival rate of less than 5%. Complete surgical resection represents the only curative treatment option and 5-year survival rates of 20-25% can be achieved following curative resection and adjuvant chemotherapy. Although pancreatic surgery is considered one of the most technically demanding and challenging procedures, there has been constant progress in surgical techniques and advances in perioperative care with a modern interdisciplinary approach including anesthesiology, oncology, radiology and nursing. This has reduced morbidity and especially mortality rates in high-volume centers. Among extended resection procedures multivisceral and venous resections are technically feasible and should be considered if a complete tumor resection can be achieved. Multimodal regimens have shown promising results, however, only adjuvant chemotherapy is supported by solid evidence from randomized controlled trials. (orig.) [German] Das duktale Adenokarzinom ist der haeufigste maligne Pankreastumor. Trotz intensiver Anstrengungen auf dem Gebiet der Pankreasforschung konnte die Gesamtprognose in den vergangenen Jahren nicht entscheidend verbessert werden. Die einzige potenziell kurative Therapie ist die chirurgische Resektion. In Kombination mit einer adjuvanten Chemotherapie liegen die 5-Jahres-Ueberlebensraten aktuell bei 20-25%. Dank kontinuierlicher Weiterentwicklung der chirurgischen Operationstechnik und Verbesserungen der perioperativen Versorgung der Patienten mit einer engen interdisziplinaeren Zusammenarbeit (Chirurgie, Anaesthesie, Onkologie, Radiologie und Pflege) konnten die perioperative Morbiditaets- und Mortalitaetsraten in den vergangenen Jahren deutlich gesenkt werden. Unter den erweiterten Resektionsverfahren sind Venen- oder multiviszerale Resektionen technisch sicher

  13. APR-2 Tropical Cyclone Observations

    Science.gov (United States)

    Durden, S. L.; Tanelli, S.

    2011-01-01

    The Second Generation Airborne Precipitation Radar (APR-2) participated in the Genesis and Rapid Intensification Processes (GRIP) experiment in August and September of 2010, collecting a large volume of data in several tropical systems, including Hurricanes Earl and Karl. Additional measurements of tropical cyclone have been made by APR-2 in experiments prior to GRIP (namely, CAMEX-4, NAMMA, TC4); Table 1 lists all the APR-2 tropical cyclone observations. The APR-2 observations consist of the vertical structure of rain reflectivity at 13.4 and 35.6 GHz, and at both co-polarization and crosspolarization, as well as vertical Doppler measurements and crosswind measurements. APR-2 normally flies on the NASA DC-8 aircraft, as in GRIP, collecting data with a downward looking, cross-track scanning geometry. The scan limits are 25 degrees on either side of the aircraft, resulting in a roughly 10-km swath, depending on the aircraft altitude. Details of the APR-2 observation geometry and performance can be found in Sadowy et al. (2003).The multiparameter nature of the APR-2 measurements makes the collection of tropical cyclone measurements valuable for detailed studies of the processes, microphysics and dynamics of tropical cyclones, as well as weaker systems that are associated with tropical cyclone formation. In this paper, we give a brief overview of how the APR-2 data are processed. We also discuss use of the APR-2 cross-track winds to estimate various quantities of interest in in studies of storm intensification. Finally, we show examples of the standard products and derived information.

  14. Respirators: APR Issuer Self Study 33461

    Energy Technology Data Exchange (ETDEWEB)

    Chochoms, Michael [Los Alamos National Laboratory

    2016-07-13

    Respirators: APR Issuer Self-Study (course 33461) is designed to introduce and familiarize employees selected as air-purifying respirator (APR) issuers at Los Alamos National Laboratory (LANL) with the responsibilities, limitations, procedures, and resources for issuing APRs at LANL. The goal is to enable these issuers to consistently provide proper, functioning APRs to authorized users

  15. Arrêt cardiaque au cours d'une chirurgie de kyste hydatique du foie

    Science.gov (United States)

    Ouzzad, Omar; Kechna, Hicham; Moudden, Mohamed Karim; Chkoura, Khalid; Hanafi, Sidi Mohamed

    2015-01-01

    L'hydatidose est une pathologie fréquente qui reste encore endémique au Maroc. Sa localisation privilégiée est le foie. Son traitement repose essentiellement sur la chirurgie. Celui-ci est parfois incriminé dans la survenue de réactions allergiques sévères pouvant menacer le pronostic vital. Nous rapportons un nouveau cas de réaction anaphylactique sévère de grade IV peropératoire au cours d'une chirurgie de kystes hydatiques multiples du foie. Nous insistons sur la nécessité de sa reconnaissance rapide afin d'instaurer rapidement un traitement efficace. La prévention de cet accident est basée sur des précautions chirurgicales pour éviter les fuites ou les ruptures accidentelles peropératoires des kystes hydatiques. PMID:26664533

  16. Eine neuartige Roboterkinematik für die laparoskopische Single-Port Chirurgie

    OpenAIRE

    Sanagoo, Arash

    2015-01-01

    Minimal invasive Operationstechniken haben sich in den letzten Jahren sehr schnell weiterentwickelt. Unter anderem konnte sich die roboterassistierte Laparoskopie auf dem Markt etablieren. Solche Systeme können jedoch sehr eingeschränkt für die Single-Port Laparoskopie eingesetzt werden. Im Rahmen dieser Arbeit wurde basierend auf einer sphärischen Parallelkinematik ein kompakter Manipulator entwickelt. Dieser Manipulator wird in erster Linie für die laparoskopische Single-Port Chirurgie g...

  17. Diagnostic Strategy in APR1400

    International Nuclear Information System (INIS)

    These features may bring out changes in operator tasks, changing the characteristics of tasks, or creating new tasks. Diagnostic strategy for identifying anomaly may be different especially in APR1400 from that in the analog control room due to the change of human-system interface, i.e. alarm system and display system. Since the first plant of APR1400 is being built at this moment, it is not known what strategies the operators will adopt in diagnosis tasks in the new operating environment. In this light, this paper aims at investigating operator's diagnostic strategies which are appropriate for APR1400. In order to collect data, several different approaches which are complementary are used to identify diagnostic strategies in the digital control room: analysis on audio/video recording of operation, observation in the simulator, and interview with the operators. The result shows that the digital control room introduces new strategies in the diagnosis, compared with the analog control room, and also changed the characteristics of strategies, mostly, by getting more support from the computerized system. This paper investigated how the digitalized control room may influence operator's diagnostic strategies. Several different approaches, i. e., audio/video record, observation of training, and the interview with operators, were used to gather information about the operator's behaviors. As a conclusion, this paper figured out that the digital control room introduces new strategies in the diagnosis, compared with the analog control room, and also changed the characteristics of the strategies, mostly, by getting more support from the computerized system. The operators interviewed also commented that the diagnosis in the APR1400 is quicker, more correct, and easier, compared with the analog control room

  18. Chirurgie filtrante du glaucome: sécurité et efficacité

    OpenAIRE

    Varga, Zsolt

    2015-01-01

    Le Glaucome est l’une des causes principales de cécité dans le monde. Le nombre de personnes atteintes devrait presque doubler d’ici 25 ans en raison du vieillissement de la population. La chirurgie du glaucome est effectuée pour réduire la pression intraoculaire et arrêter ou ralentir la progression du glaucome avancé non-contrôlé, afin d’éviter la perte de vision et préserver la qualité de vie. De nouvelles interventions chirurgicales ont été développées avec pour objectif de réduire le tau...

  19. Mechanistic studies of APR-246 in leukemia

    OpenAIRE

    Ali, Dina Mahmoud

    2013-01-01

    PRIMA-1and its analog APR-246 are novel drugs that restore the active conformation of mutated and unfolded p53 protein and induce apoptosis and cell death in various tumors in pre-clinical models. We first aimed to explore the effects of APR-246 alone and in combination with other drugs in acute myeloid leukemia (AML) in vitro. APR-246 induced dose-dependent apoptosis and increased active caspase-3 and p53 protein levels as well as the Bax/Bcl-2 ratio independently of TP53...

  20. Évaluation de la fonction ventriculaire gauche en pré et postopératoire. Après chirurgie de pontage aorto-coronarien

    OpenAIRE

    Serruys, Patrick; Hugenholtz, Paul

    1980-01-01

    textabstractThe effect of coronary artery bypass graft (CBG) on left ventricular performance was evaluated by analysing preoperative (preop) and postoperative (postop) pressure-derived measurements from tip manometers during atrial pacing stress (APS) and resting segmental wall motion (SWM) of 50 patients (pts), restudied 12 months after CBG. Preoperatively, graft flow and reactive hyperemia (RH) were also measured. End diastolic pressure (EDP) maximal velocity of contractile element (Vmax) d...

  1. Epithelioid sarcoma: a retrospective study of conservative treatment with initial surgery and radiotherapy; Sarcomes epithelioides: etude retrospective apres chirurgie conservatrice et radiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Figueiredo, B.H. de; Kantor, G.; Duparc, A.; Guerder, C. [Institut Bergonie, Centre Regional de Lutte Contre le Cancer, Service de Radiotherapie, 33 - Bordeaux (France); Bui Nguyen Binh, M.; Coindre, J.M. [Institut Bergonie, Centre Regional de Lutte Contre le Cancer, Service de pathologie, 33 - Bordeaux (France); Stoeckle, E. [Institut Bergonie, Centre Regional de Lutte Contre le Cancer, Service de Chirurgie, 33 - Bordeaux (France); Bui, B.N. [Institut Bergonie, Centre Regional de Lutte Contre le Cancer, Service d' Oncologie Medicale, 33 - Bordeaux (France)

    2007-09-15

    Introduction Epithelioid sarcoma is a rare type of soft tissue sarcomas with a high risk of recurrence both local and distant. The place of surgical conservative treatment and the role of radiation therapy remain controversial. Patients and methods A series of 9 consecutive patients treated with initial conservative surgery and postoperative radiotherapy (median dose of 52.8 Gy) from 1987 to 2006 in the same institution was analyzed. Results With a median follow-up of 40 months (range 15-153 months), the rate of local, nodal and distant relapse is respectively 56%, 11% and 33%. The rate of death is 44.5%. No imputation has been performed. Conclusion Even with a high rate of local relapse observed, a conservative treatment does not seem to influence badly the overall survival (55.5% alive at 40 months). Indeed the rate of distant relapse and death are comparable with those found in the literature. Moreover relapse occurred almost within the irradiated volumes. An improvement of dose could be also discussed. (authors)

  2. Contribution a l'étude des infections nosocomiales "service de chirurgie A "C.H.UTlemcen

    OpenAIRE

    LETRECHE, AMINE SOUFIANE

    2012-01-01

    Les infections nosocomiales (fl%) posent un véritable problème de santé publique du fait de leur fréquence, leur gravité, et Idur cout socio-économique, notre travail réalisé dans le cadre de «Contribution à l'étude des infections nosocomiales au niveau chirurgie A » qui s'est déroulée en centre Hospitalo- Universitaire Tlemcen en 2012. Qui avait pour objectifs de déterminer la fréquence globale des infections nosocomiales dans le service de chirurgie A et d'évçquer les princip...

  3. La chirurgie coronaire sous circulation extra-corporelle chez le patient diabétique

    Science.gov (United States)

    Moutakiallah, Younes; Benzaghmout, Khadija; Aithoussa, Mahdi; Atmani, Nourreddine; Amahzoune, Brahim; Hatim, Abdedaim; Drissi, Mohamed; Benyass, Aatif; ElBekkali, Youssef; Boulahya, Abdelatif

    2014-01-01

    Nous rapportons les résultats de la chirurgie coronaire chez une population de coronariens diabétiques opérés sous circulation extra-corporelle dans le service de chirurgie cardiaque de l'hôpital militaire d'instruction Mohammed V de Rabat. C'est une étude rétrospective menée entre Janvier 2008 et Février 2012 (4 ans), portant sur 103 patients diabétiques consécutifs opérés pour pontage coronaire. L’âge moyen des patients était de 61±8,7ans (37-82ans) avec un sexe ratio (H/F) de 3,9. Tous les patients diabétiques de type 2 et sous traitement anti-diabétique ont été inclus dans cette étude. La sténose du tronc commun gauche était présente chez 26,2% des patients et 53,4% étaient tritronculaires. Quatre-vingt patients (78,6%) étaient insulino-nécessitant, l'Euro-score moyen était de 1,63±1% et le nombre moyen de pontage de 2,3±0,7. Les durées moyennes de la circulation extra-corporelle et du clampage aortique étaient respectivement de 134,4 ± 42 min et 76 ± 28 min. La mortalité hospitalière était de 2 décès (1,9%), les durées moyennes de ventilation artificielle, du séjour en réanimation et du séjour postopératoire étaient respectivement de 7h (5-16h), 48h (42-52h) et 15,6 ± 8,6 jours. Les complications postopératoires étaient l'infarctus du myocarde, l'infection de paroi, la médiastinite et le bas débit cardiaque chez respectivement 1,9%, 10,7%, 3,9% et 1,9% des patients. Il ressort de notre étude, que les facteurs prédictifs d'infection post opératoire étaient la durée de ventilation artificielle (p = 0,002), la durée de la circulation extra-corporelle (p < 0,001) en plus du tabac (p = 0,004) et de l'obésité (p = 0,005). Les patients ont été contactés par téléphone ou lors de la consultation régulière de contrôle. Le taux de suivi a atteint 92,1% et la survie à 2 ans était de 98,9% des patients contrôlés avec une mortalité tardive de 1% avec un décès suite à un accident vasculaire c

  4. Coping Capability of APR Against Fukushima Accidents

    International Nuclear Information System (INIS)

    Major threats on Fukushima Daiichi plant are earthquake, tsunami, SBO (Station Black Out), and hydrogen burning and explosion. Following the 9.1 magnitude earthquake, tsunami of 15m-height caused Emergency Diesel Generator (EDG) trouble and SBO. APR+ (Advanced Power Reactors Plus) has been basically designed to have the seismic design basis of Safe Shutdown Earthquake (SSE) 0.3g, a 4-train safety concept based on N+2 design philosophy, and a Passive Auxiliary Feedwater System (PAFS). Safety issues on the Fukushima-type accident have been extensively reviewed to enhance APR+ safety. After the review, many items was selected in the APR+ standard design to cope with the accidents. The items can be categorized as follows; Design of structure and equipment against earthquakes and coastal flooding, Integrity of electric power, cooling, and fire protection systems on inundation, Countermeasures against severe accident, and Emergency response and emergency medical systems. The key items include enhancement of seismic design for Main Control Room (MCR) and capability of cooling water intake, improvement of facilities entrance such as a water tight door against tsunami or flood, provision for external cooling water of PCCT (Passive Condensate Cooling Tank), diversity design for emergency electric power sources, and capability extension of a battery for supporting the 72-hour copying time. These items to enhance the safety will have been applied to the APR+ design. Consequently, APR+ can provide higher reliability and safety against tsunami and earthquake

  5. Separate Effect Test for APR+ DVI+

    International Nuclear Information System (INIS)

    DVI and FD are our own design features adopted into APR1400. This study focuses on improving their performance for the APR+. From a preliminary study, conceptual design for DVI+ has been developed. Various separate effect tests were performed to evaluate the performance of the design concept and to develop a basic design. For DVI+ design, tests for DVI duct performance and vibration characteristics were performed. For FD+ design, sensitivity tests for major design parameters were performed. This study also includes a development of design for the reactor flow distribution test as well as FD+ overall performance test

  6. Les interventions après feu

    OpenAIRE

    Toutchkov, M.; Duché, Y.; Prevosto, B.; Quesney, T.; Vennetier, M.

    2013-01-01

    This chapter presents various post-fire management options for Pinus halepensis stands / Ce chapitre présente les différentes manière de gérer l'après-feu dans les peuplements de pin d'Alep incendiés

  7. Containment performance analysis for EU APR1400

    International Nuclear Information System (INIS)

    During a severe accident, as the last barrier of DID (Defense In Depth) strategy, the containment has an important role to limit the release of the radioactive material to environment. The containment should be able to maintain its structural integrity to prevent the release of the radioactive materials contained in it. In this paper, the behavior of pressure and temperature in the containment is evaluated for various accident conditions. EU APR1400 (European APR1400) is equipped with RDS (Rapid Depressurization System), HMS (Hydrogen Mitigation System), SACSS (Severe Accident Containment Spray System), and PECS (Passive Ex vessel Cooling System) to mitigate the severe accident consequences and eventually to keep the containment integrity. Depending on the availabilities of these mitigation systems, the containment undergoes different transients in pressure and temperature

  8. Complication s post- opératoires de la chirurgie d’exérèse pulmonaire á l’institut de cardiologie d’Abidjan.

    Directory of Open Access Journals (Sweden)

    Iteke FR.

    2014-09-01

    Full Text Available OBJECTIFS : le but de ce travail était d’évaluer les complications post opératoires de la chirurgie d’exérèse pulmonaire à l’ICA. PATIENTS ET MÉTHODES : Il s’agit d’une étude rétrospective à visée descriptive sur une période de six ans. 40 dossiers des patients ayant bénéficié d’une exérèse pulmonaire étaient colligés et analysés. Tous les patients qui avaient bénéficié d’une exérèse pulmonaire et dont les dossiers étaient complets, étaient inclus dans l’étude. Les variables étudiées étaient sociodémographiques, les complications post ainsi que l’évolution. RÉSULTATS : l’âge moyen était de 43,3 ans avec une prédominance du sexe masculin (sexe ratio 2,6. Les poumons détruits, séquelles de tuberculose constituaient le principal diagnostic pré opératoire. Tous les patients avaient une fonction respiratoire pré opératoire (Spirométrie et gazométrie acceptable. L’atélectasie (47,5% et la pneumopathie (22,5% constituaient les principales complications pleuro pulmonaires post opératoires. Les complications cardiovasculaires étaient dominées par les troubles du rythme 53,3% dont 65% au cours des pneumonectomies. L’hémorragie était présente dans 15% des cas et avait nécessité une reprise chirurgicale. L’hyponatrémie 40,7%, était la principale complication métabolique. L’anémie 62,5%, constituait la principale complication hématologique. Un décès (2,5% suite à un choc hémorragique et septique décompensés après une reprise chirurgicale, à J3 post pneumonectomie était observé. CONCLUSION : La chirurgie d’exérèse pulmonaire est à risque des complications majeures post opératoires, d’où la nécessité d’une bonne sélection des patients, une bonne préparation pré opératoire ainsi qu’une bonne gestion per et post opératoire des patients. OBJECTIVES: The aim of this work was to evaluate the postoperative complications of lung resection surgery at

  9. Conception optimale d'instruments robotisés à haute mobilité pour la chirurgie mini-invasive

    OpenAIRE

    Sallé, Damien

    2004-01-01

    Cette thèse concerne la conception optimale de systèmes robotisés à haute mobilité pour la chirurgie mini-invasive. Elle este basée sur un processus d'optimisation par algorithmes évolutionnaires mult-objectifs, couplés à une simulation réaliste de la tache chirurgicale qui prend en compte tous les paramètres nécessaires à l'évaluation fidèle des robots. Cette méthodologie de conception a été appliquée au geste de suture lors d'une procédure de pontage coronarien. Elle aboutit à l'obtention d...

  10. Apreçamento de derivativos bidimensionais

    Directory of Open Access Journals (Sweden)

    Hugo Daniel de Oliveira Azevedo

    2005-09-01

    Full Text Available Neste artigo analisamos o apreçamento de contratos que tenham seus resultados atrelados a mais de um ativo subjacente, em especial, opções bidimensionais. Para isto usamos a fórmula desenvolvida por Margrabe (1978 e o modelo de árvores de Rubinstein (1991a. Em seguida apresentamos exemplos práticos de opções bidimensionais e apreçamos estas opções. Além disto, sugerimos a incorporação de outros instrumentos, negociados no exterior, ao mercado de derivativos brasileiro.In this article we analyze the pricing of contracts that have their payoffs linked to more than one underlying asset, in special, bidimensional options. To achieve this purpose we use the formula developed by Margrabe (1978 and the tree model of Rubinstein (1991a. Next, we present practical examples of bidimensional options and price these options. Moreover we suggest the incorporation of two other instruments, negotiated abroad, to the Brazilian derivative markets

  11. Design Characteristics of the Passive Auxiliary Feedwater System in APR+

    International Nuclear Information System (INIS)

    The passive auxiliary feedwater system (PAFS) is a typical passive safety system implemented for the APR+. The auxiliary feedwater system (AFWS) in the APR1400, which is the reference plant of the APR+, consists of two motor driven pumps, two turbine driven pumps, two water storage tanks, and related pipes and valves. The AFWS feeds emergency water to steam generators to cool down the reactor coolant system when the main feedwater is lost. To enhance the safety, the PAFS replaces the AFWS with a passive condensation heat exchanger (PCHX), a passive condensation cooling tank (PCCT), and a few valves and pipes in the APR+ design. In this paper, we propose the design requirements and conceptual design of the PAFS in order to evaluate the operability of the PAFS, to develop the APR+'s general arrangements for the auxiliary building, and to identify the important parameters to be quantified by experiments

  12. Design Characteristics of the APR+ Containment Spray System

    International Nuclear Information System (INIS)

    We, KEPCO E and C, are implementing APR+ design development phase II project, which is owned by the KHNP. The APR+ Containment Spray (CS) System is developed as a four (4) 100%-capacity train system which shares the pumps, heat exchangers, valves, and piping with the Shutdown Cooling (SC) System, meeting the N+2 design concept (capable of satisfying the safety function with a single failure and a concurrent component unavailability due to maintenance) and still maintaining the number and capacity of the system components similar to the APR1400 CS System and SC System combined. The design concept and system configuration of the APR+ CS System are presented

  13. Design Characteristics of the APR+ Containment Spray System

    Energy Technology Data Exchange (ETDEWEB)

    Doh, Gyu Bong; Park, Jong Ha; Chang, Jae Wang [KEPCO Engineering and Construction Co., Yongin (Korea, Republic of)

    2012-05-15

    We, KEPCO E and C, are implementing APR+ design development phase II project, which is owned by the KHNP. The APR+ Containment Spray (CS) System is developed as a four (4) 100%-capacity train system which shares the pumps, heat exchangers, valves, and piping with the Shutdown Cooling (SC) System, meeting the N+2 design concept (capable of satisfying the safety function with a single failure and a concurrent component unavailability due to maintenance) and still maintaining the number and capacity of the system components similar to the APR1400 CS System and SC System combined. The design concept and system configuration of the APR+ CS System are presented

  14. Performance analysis of a Passive Auxiliary Feedwater System in APR+

    International Nuclear Information System (INIS)

    The Advanced Power Reactor Plus (APR+), which is a GEN III+ reactor based on the APR1400, is being developed in Korea. In order to enhance the safety of the APR+, a passive auxiliary feedwater system (PAFS) has been adopted in the APR+. The PAFS replaces the conventional active auxiliary feedwater system (AFWS) by introducing a natural driving force mechanism while maintaining the system function of cooling the primary side and removing the decay heat. The purpose of this paper is to evaluate the performance of the PAFS under design basis events using best-estimated thermalhydraulic codes

  15. Vingt ans après…

    Directory of Open Access Journals (Sweden)

    François Burgat

    2002-05-01

    Full Text Available Le dixième numéro des Chroniques Yéménites, publié vingt ans après la création du Centre Français d'Archéologie et de Sciences Sociales de Sanaa reflète des ambitions souvent exprimées: donner une chance aux jeunes chercheurs et couvrir un large éventail disciplinaire au service de l'affirmation de la vocation régionale du Centre. Depuis Sanaa ou Paris, chercheurs, doctorants ou stagiaires, de l'Ecole normale supérieure, de l'INALCO, de l'Université de Sanaa et de bon nombre d'institu...

  16. Untersuchung des Reinigungseffektes von Ultraschall auf Oberflächen von Chirurgie-Instrumenten und dessen prototypische Umsetzung in ein Dekontaminationsverfahren

    OpenAIRE

    Kahlen, Insa

    2012-01-01

    Viele Medizinprodukte aus der Chirurgie stellen besonders hohe Anforderungen an ihre Aufbereitung, da sie z.B. wie die so genannten „Langschaftinstrumente“ enge und sehr langgestreckte Lumen aufweisen, die zum Teil nicht einsehbar sind. Laut der Richtlinie „Anforderungen an die Hygiene bei der Aufbereitung von Medizinprodukten“ vom RKI und der BfArM soll die Aufbereitung von solchen Medizinprodukten durch Anwendung validierter Verfahren durchgeführt werden und der Erfolg stets nachvollziehbar...

  17. Supplementation of fat grafts with adipose-derived regenerative cells in reconstructive surgery [Stammzellangereicherte Fetttransplantation in der rekonstruktiven Chirurgie

    Directory of Open Access Journals (Sweden)

    Herold, C.

    2012-09-01

    Full Text Available [english] Introduction: The fraction of regenerative cells in adipose tissue has been described to be even higher than in bone marrow. Adipose tissue itself is excessively available in most patients. Given that adipose tissue is abundant in majority of patients adipose derrived stem cells (ASCs have come under scrutiny for regenerative procedures in reconstructive surgery.Material and methods: ASCs were extracted by the Celution system for enrichment of fat grafts that were administered in patients with decreased wound healing, soft tissue or scar defects.Results: All patients were satisfied after reconstruction with ASCs augmented fat grafts and no side effects were observed. Discussion: The Celution system provides fast recovery of ASCs which can be immediately utilized for appropriate application. Since a high number of stem cells are harvested from fat tissue no expansion of cells is needed as described for bone marrow derived stem cells. Enrichment of fat graft with ASCs is of great interest due to their reported angiogenetic effect. The reported cases demonstrate the potential of ASCs in the field of regenerative medicine and encourage further application in reconstructive surgery.[german] Einleitung: Es konnte gezeigt werden, dass der Anteil regenerativer Zellen im Fettgewebe höher als im Knochenmark ist. Fettgewebe hingegen ist bei den meisten Patienten exzessiv vorhanden. Das legt den Einsatz von ASCs (adipose derived stem cells bei regenerativen Anwendungen in der rekonstruktiven Chirurgie nahe.Material und Methoden: Mit dem Celution System von Cytori Therapeutics Inc. prozessierte, ASC angereicherte Fetttransplantate werden an vier Patienten mit Weichteildefiziten und störenden Narben sowie Wundheilungsstörungen angewendet.Ergebnisse: Insbesondere bei Patienten mit Weichteildefiziten und Narben konnte eine suffiziente Volumenaugmentation und ansprechende Verbesserung der Narben erzielt werden. Es wurden keine Nebenwirkungen

  18. Performance Analysis of APR+ PAFS for CDF evaluation

    International Nuclear Information System (INIS)

    The Advanced Power Reactor Plus (APR+), which is a GEN III+ reactor based on the APR1400, is being developed in Korea. In order to enhance the safety of the APR+, a passive auxiliary feedwater system (PAFS) has been adopted. The PAFS replaces the conventional active auxiliary feedwater system (AFWS) by introducing a natural driving force mechanism while maintaining the system functions of cooling the primary side and removing the decay heat. As the PAFS completely replaces the conventional active auxiliary feedwater system (AFWS), it is necessary to verify its cooling capacity for the core damage frequency (CDF) evaluation. This paper discusses the cooling performance of the PAFS in transient accidents

  19. Performance Analysis of APR+ PAFS for CDF evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Sang Hee; Kim, Han Gon [Korea Hydro and Nuclear Power Co., Daejeon (Korea, Republic of)

    2011-05-15

    The Advanced Power Reactor Plus (APR+), which is a GEN III+ reactor based on the APR1400, is being developed in Korea. In order to enhance the safety of the APR+, a passive auxiliary feedwater system (PAFS) has been adopted. The PAFS replaces the conventional active auxiliary feedwater system (AFWS) by introducing a natural driving force mechanism while maintaining the system functions of cooling the primary side and removing the decay heat. As the PAFS completely replaces the conventional active auxiliary feedwater system (AFWS), it is necessary to verify its cooling capacity for the core damage frequency (CDF) evaluation. This paper discusses the cooling performance of the PAFS in transient accidents

  20. Involvement of Stringent Factor RelA in Expression of the Alkaline Protease Gene aprE in Bacillus subtilis

    OpenAIRE

    Hata, Michihiro; Ogura, Mitsuo; Tanaka, Teruo

    2001-01-01

    Expression of Bacillus subtilis aprE, encoding an extracellular alkaline protease, is positively regulated by phosphorylated DegU, the regulator of a two-component regulatory system, DegS-DegU. We found that the expression of an aprE′-′lacZ fusion was greatly reduced in a disruption mutant with a mutation of relA, which encodes the stringent factor RelA. The level of DegU in the relA mutant was similar to that in the wild-type cell. A relA degU double mutation did not result in a further decr...

  1. The development of a passive auxiliary feedwater system in APR+

    International Nuclear Information System (INIS)

    The Advanced Power Reactor Plus (APR+) is being developed in Korea. APR+ is a GEN III+ reactor on the basis of the APR1400. To meet the requirements of GEN III+ reactors, the economics and the safety of the APR+ are further enhanced. One of the basic principles of APR+ safety systems is the adoption of hybrid safety systems. Passive safety systems replace the current active safety systems from an economic point of view. The passive aux. feedwater system (PAFS) is one of the passive safety features adopted in the APR+. The PAFS replaces the conventional active auxiliary feedwater system by introducing a natural driving force mechanism while maintaining the system's basic Junction of cooling down the primary side and removing the decay heat. In order to satisfy the single failure criterion, the PAFS is composed of two independent trains. Each train has one steam condensing heat exchanger of 100% capability and one PCCT (Passive Condensation Cooling water Tank) of 100% capability. Basic design is underway and separate effect tests and integral effect tests will be performed to demonstrate the performance of the PAFS. (authors)

  2. The core design of the advanced power reactor plus (APR+)

    International Nuclear Information System (INIS)

    Advance Power Reactor Plus (APR+), a pressurized water reactor and an improved nuclear power reactor based on the Advanced Power Reactor 1400 MWe (APR1400) in Korea, has been developed with 18-month cycle operation strategy from its initial core. The APR+ core power is 4290 MWth which corresponds to a 1500 MWe class nuclear power plant. The reactor core consists of 257 fuel assemblies. Comparing with APR1400 core design, 16 fuel assemblies are added. Its cycle length is expected about 450 EFPD directly from initial core, although most of previous other plants had been started according to their annual or 15-month cycle operation schedule at their initial core and gone to 18-month after third - fourth cycle. In order to reduce the peaking power, fuel pin configurations of the assembly, are optimized by using some low enriched fuel pins and gadolinia bearings. APR+ core has been met the requirements as well as the above cycle length requirement; 1) peaking factor, 2) Negative MTC(Moderator Temperature Coefficient), 3) sufficient shutdown margin, 4) convergent Xenon stability Index. The maximum rod burnup and the discharge fuel assembly burnup are also satisfied those of the limit. It is expected to acquire the standard design approval by the end of 2012 by the Korean nuclear regulatory. (authors)

  3. Development of Reference Source Terms for EU-APR1400

    International Nuclear Information System (INIS)

    These source terms are developed for the typical U. S. NPP and do not reflect the design characteristics of EU-APR1400 (1,400 MWe PWR) which will be applied for the EUR certification in European countries. The process of developing the RST for EU-APR1400 is to undergo a similar process that NUREG-1465 had gone through when it came out with its proposed source terms. The purpose of this study is to develop the EU-APR1400 design-specific RST complied with the EUR. The Large LOCA is the reference equence used in the NUREG-1465 evaluation, whereas the EUAPR1400 risk-significant sequences are dominated by small LOCA and non-LOCA sequences. Moreover, when considering the EU-APR1400 has many design features to mitigate the consequences of severe accident phenomena, it is not surprising that the aspects of both release fractions and durations are distinctly different from NUREG-1465. This RST will be continuously updated to reflect to the design features of EU-APR1400, and then, be used as the reference for design purposes such as criteria satisfaction of radioactivity releases, equipment survivability, control room habitability for severe accident, and so on

  4. Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conservative surgery enhances late toxicities; La chimiotherapie concomitante de la radiotherapie augmente la toxicite tardive apres chirurgie conservatrice du cancer du sein

    Energy Technology Data Exchange (ETDEWEB)

    Toledano, A. [Hopital Tenon, Service d' oncologie-radiotherapie 75 - Paris (France); Garaud, P.; Body, G.; Le Floch, O.; Calais, G. [Centre Hospitalier Universitaire Bretonneau, 37 - Tours (France); Serin, D. [Institut Sainte-Catherine, 84 - Avignon (France); Fourquet, A. [Institut Curie, 75 - Paris (France); Bosset, J.F.; Miny-Buffet, J. [Centre Hospitalier Universitaire Minjoz, 25 - Besancon (France); Favre, A. [Centre Hospitalier Universitaire La Source, 45 - Orleans (France); Azria, D. [Centre de Lutte Contre le Cancer Val d' Aurelle, 34 Montpellier (France)

    2006-06-15

    In 1996, a multicenter randomized study comparing after breast-conservative surgery. sequential vs concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) was initiated (ARCOSEIN study). Seven hundred sixteen patients were included in this trial. After a median follow-up of 6.7 (4.3 -9) years, we decided to prospectively evaluate the late effects of these two strategies. Patients and methods - A total of 297 patients were asked to follow-up from the five larger including institutions. Seventy-two percent (214 patients) were eligible for late toxicity. After breast-conserving surgery with axillary dissection, patients were treated either with sequential treatment with CT first followed by RT (arm A) or CT administered concurrently with RT (arm B). In all patients, CT regimen combined mitoxantrone (12 mg/m{sup 2}). 5-FU (500 mg/m{sup 2}), and cyclophosphamide (500 mg/m{sup 2}), 6 cycles (day 1-day 21). In arm B, patients received concurrently the first 3 cycles of CT with RT. In arm A, RT started 3 to 5 weeks after the 6. cycle of CT. Conventional RT was delivered to the whole breast using a 2 Gy-fraction protocol to a total dose of 50 Gy ({+-} boost to the primary tumour bed). The assessment of toxicity was blinded to treatment and was graded by the radiation oncologist according to the LENT-SOMA scale. Skin pigmentation was also evaluated using a personal 5-points scoring system (excellent, good, moderate, poor, very poor). Results - Among the 214 evaluated patients, 107 were treated in each arm. The two populations were homogeneous for patients', tumors' and treatment characteristics. Subcutaneous fibrosis (SF), telangiectasia (T), skin pigmentation (SP), and breast atrophy (BA) were significantly increased in arm B. Twenty patients experienced grade superior or equal to 2 (SF) in arm B vs five in arm A (P 0.003). Twenty-five and seven patients showed grade superior or equal to 2 (T) in ann B and A, respectively (P = 0.001). Forty-four and twenty patients showed grade superior or equal to 2 (BA) in arm B and A, respectively (P 0.0006). Thirty patients experienced grade superior or equal to 3 (SP) in arm B vs fifteen in arm A (P= 0.02). No statistical difference was observed between the two arms concerning grade superior or equal to 2 pain, breast oedema and lymphedema. No deaths were caused by late toxicity. Conclusion - Following breast conserving surgery, the concurrent use of CT with RT is significantly associated with an increase incidence of grade 2 or greater late side effects. (author)

  5. System Response Analysis of LOCV for APR1400 Using KNAP

    International Nuclear Information System (INIS)

    Korea Electric Power Research Institute (KEPRI) of Korea Electric Power Corporation (KEPCO) has been developed the non-loss-of-coolant accident (non-LOCA) analysis methodology, called as the Korea Non-LOCA Analysis Package (KNAP), for the typical Optimized Power Reactor 1000 (OPR1000) plants. Considering current licensing methodology conducted by ABB-CE, however, the KNAP could be applied to Advanced Power Reactor 1400 (APR1400). In spite of some difference in components of two plant types, there is a close resemblance between their nuclear steam supply systems (NSSS). So, in this study, the loss of condenser vacuum (LOCV) event were analyzed using KNAP for APR1400 to estimate the feasibility of the application and the results were compared with those given in APR1400 Standard Safety Analysis Report (SSAR), which were calculated using the CESEC-III code of ABB-CE. Through the study, it was concluded that the KNAP could be applicable to APR1400 on the view point of LOCV event

  6. Conception et réalisation d'une instrumentation terminale intégrée en chirurgie mini-invasive robotisée

    OpenAIRE

    Van Meer, Frédérick

    2005-01-01

    On assiste depuis quelques années à l'émergence d'une robotique médicale proposée pour accroître la précision des actes, améliorer les conditions de travail de l'équipe chirurgicale et le confort du patient. Nos recherches s'inscrivent dans le projet national EndoXiroB du RNTS dont l'objectif est la réalisation d'un ensemble robotisé de chirurgie mini-invasive. Elles sont dédiées à la conception et à la réalisation, en s'appuyant sur les technologies microsystèmes, d' une instrumentation chir...

  7. Chirurgie angeborener Herzfehler

    Science.gov (United States)

    Schreiber, Christian; Libera, Paul; Lange, Rüdiger

    Störungen der embryonalen Entwicklung in der frühen Phase der Schwangerschaft können zu Fehlbildungen am Herz- und Gefäßsystem führen. Die Häufigkeit liegt bei 0.8-1 % aller lebend geborenen Kinder. In Deutschland werden jedes Jahr etwa 6.000 Kinder mit einem Herzfehler geboren (Quelle: http://www.kompetenznetzahf.de). Das Spektrum reicht von einfachen Fehlern, die das Herz-Kreislauf-System wenig beeinträchtigen, bis zu sehr schweren Herzerkrankungen, die unbehandelt zum Tode führen. Fortschritte der Kinderkardiologie, Herzchirurgie und Anästhesie ermöglichen heute ein Überleben bei über 90 % der Patienten. Auch die spezialisierte Pränataldiagnostik (vorgeburtliche Diagnostik) ermöglicht schon die frühe Weichenstellung für mögliche Therapieoptionen. Bei der chirurgischen Therapie ist jedoch festzuhalten, dass ein Herzfehler entweder korrigierend behandelt wird oder nur "palliiert“ werden kann. Bei letzterer Therapie wird bei einem Patienten eine medizinische Maßnahme durchgeführt, die nicht die Herstellung normaler Körperfunktionen zum Ziel hat, sondern in Anpassung an die physiologischen Besonderheiten des Patienten dessen Zustand lediglich stabilisiert und optimiert. Dies kann beispielsweise bei einer nicht korrigierbaren angeborenen Fehlbildung notwendig sein, bei der lediglich eine funktionelle Herzkammer vorhanden ist (z. B. hypoplastisches Linksherz). Hierbei muss eine prothetische Verbindung zur Lungenstrombahn in der Folgezeit entfernt werden.

  8. LASER-CHIRURGIE

    OpenAIRE

    КУБЛАНОВА А.А.; САПАРГАЛИЕВА С.А.; ДЕНИСОВА О.С.

    2015-01-01

    Das Wort „Laser“ steht für „Light Amplification by Stimulated Emission of Radiation“. Laserstrahlen sind starke Lichtstrahlen, die durch elektrische Stimulation eines bestimmtes Stoffs (fest, flüssig oder gasförmig) erzeugt werden.Laser werden nach dem Stoff benannt, mit dem sie den Strahl erzeugen. Weitverbreitete Laser sind u. a. Kohlendioxidlaser und Argonlaser.Die Kombination aus der Stärke eines Lichtstrahls und der Fähigkeit, diesen auf eine kleine Fläche zu konzentrieren, verhilft Lase...

  9. Verbal Communication in the APR1400 Advanced Control Room

    International Nuclear Information System (INIS)

    This paper introduces the characteristics of communication in advanced main controlghd rooms (MCRs) and some observations from a case study performed for APR1400 MCR. In advanced MCRs, operators need not maintain the same communication patterns as they do in conventional ones. For example, a senior reactor operator (SRO) does not have to rely on board operators for information acquisition and can get any information from his/her own workstation. This situation may also bring about new problems in MCRs such as lack of shared situation awareness and collaboration between MCR operators. To cope with these problems, the APR1400 MCR adapts several approaches in design and training for encouraging operators to communicate with each other. This paper introduces the possible changes of communication patterns and the countermeasures in design and training. Some findings from an integrated system validation for Shin Kori Units 3 and 4 are also presented

  10. Nuclear power protection systems performance study for APR 1400

    International Nuclear Information System (INIS)

    A study on plant protection system (PPS) of advanced power reactor (APR) 1400 which is one of the system to maintain nuclear power plant (NPP) operation safe and controllable has been conducted. The controllability aspect of NPP operation is an important aspect to assure the NPP operation safe and reliable. Accordingly, the study is limited in the performance of PPS. The method used in the study includes literature study, data collection, as well as review and analysis. The purpose of this study is to recognize that PPS performance can assure the NPP operation safely and controllable. The study concludes that there are several measurement parameters that actuate PPS systems to trip the reactor such as high pressurizer pressure, low pressurizer pressure, high containment building pressure and also manual trip. These parameters are measured by parallel sensor with parallel arrangement set on set point suitable with APR 1400 safety standard. (author)

  11. Preliminary Results Of LOCA Problem For APR1400 Reactor

    International Nuclear Information System (INIS)

    Several features of NPP with APR1400 nuclear reactor during a loss of coolant accident (LOCA) are investigated in this study. The report describes some main design characteristics of an engineering safety systems of APR1400 and the thermal hydraulic calculation results for steady-state using MARS and RELAP/SCDAPSIM codes. Large Break LOCA accident has been analyzed and evaluated based on acceptable criteria for ECCS given by US NRC. The results from cold leg break LOCA with broken area of 0.0465 m2 in case of high pressure safety injection system (HPSI) failed to operate or 2 and 4 HPSI pumps are activated. The preliminary results of this work is a part of collaboration between INST researchers and KAERI experts in using RELAP tool for safety analysis of NPPs. (author)

  12. Conceptual Design of Passive Containment Cooling System Based on APR+

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, Byongguk; No, Heecheon [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

    2013-05-15

    Passive Auxiliary Feedwater System (PAFS) is expected to work well under extended SBO, but is vulnerable to extended SBO coupled with loss of coolant accident (LOCA). Various reactors have been developed, such as AP1000, ESBWR, and KERENA, with passive containment cooling systems (PCCSs) dealing with the accident scenario of SBO with LOCA. The performance of the PCCSs is already or almost validated. Though PCCS is well adopted into BWRs, there has been no success in PWRs with concrete containment. In this paper, we suggest a new PCCS based on APR+ and represent scoping analysis results. The Fukushima accident proved the importance of treating extended SBO. To deal with extended SBO with LOCA scenario, the PCCS based on APR+ is suggested and evaluated roughly for the first time as a PWR with concrete containment.

  13. Design features of Advanced Power Reactor (APR) 1400 steam generator

    International Nuclear Information System (INIS)

    Advanced Power Reactor 1400 (APR 1400) which is to achieve the improvement of the safety and economical efficiency has been developed by Korea Hydro and Nuclear Power Co., Ltd. (KHNP) with the support from industries and research institutes. The steam generator for APR 1400 is an evolutionary type from System 80+, which is the recirculating U-tube heat exchanger with integral economizer. Compared to the System 80+ steam generator, it is focused on the improved design features, operating and design conditions of APR 1400 steam generator. Especially, from the operation experience of Korean Standard Nuclear Power Plant (KSNP) steam generator, the lessons-learned measures are incorporated to prevent the tube wear caused by flow-induced vibration (FIV). The concepts for the preventive design features against FIV are categorized to two fields; flow distribution and dynamic response characteristics. From the standpoint of flow distribution characteristics, the egg-crate flow distribution plate (EFDP) is installed to prevent the local excessive flow loaded on the most susceptible tube to wear. The parametric study is performed to select the optimum design with the efficient mitigation of local excessive flow. ATHOS3 Mod-01 is used and partly modified to analyze the flow field of the APR 1400 steam generator. In addition, the upper tube bundle support is designed to eliminate the presence of tube with a low natural frequency. Based on the improved upper tube bundle support, the modal analysis is performed and compared with that of System 80+. Using the results of flow distribution and modal analysis, the two mechanisms of flow-induced vibration are investigated; fluid-elastic instability (FEI) and random turbulence excitation (RTE). (authors)

  14. Regulatory Approach for Oversight of APR1400 Constructions

    International Nuclear Information System (INIS)

    This presentation treats of the regulatory approach for the oversight of the APR 1400. It first introduces the licensing system in Korea and after that it describes the inspection program during the construction and commissioning, operation and finally decommissioning phase. Special emphasis is put on the installation inspection (52 items), cold functional inspections (77 items), hydrostatic and hot functional test inspection (23 items) and initial fuel loading and startup test inspections (33 items)

  15. Performance verification test for APR1400 fluidic device

    International Nuclear Information System (INIS)

    Using the full scale test facility called 'VAPER', five sets of repeatability tests have been carried out to verify the performance of the Fluidic Device which is adopted in the standard design of APR1400. Quality assurance program for the APR1400 Fluidic Device verification test has been developed and applied to each set of repeatability test procedure, and precise calibration for major measuring instruments has been performed. Thus, the highest reliability and integrity of the test results was ensured. Throughout the present tests, the repeatability of the major parameter related with APR1400 Fluidic Device performance has been sufficiently confirmed. Total K factor in the actual plant system would be about 16 at high flow condition and about 105 at low flow condition, which is similar to the design goal (about 17 at high flow condition and about 100 at low flow condition) The results of the present research contributes to the smooth construction of Sin-Kori units 3 and 4, and to the promotion of domestic analytic capability for the LOCA of advanced LWR

  16. Pseudomonas syringae evades host Immunity by degrading flagellin monomers with alkaline protease AprA

    OpenAIRE

    Pel, M.J.C.; Van Dijken, A.J.H.; Bardoel, B.W.; Seidl, M. F.; Van der Ent, S.; van Strijp, J. A. G.

    2014-01-01

    Bacterial flagellin molecules are strong inducers of innate immune responses in both mammals and plants. The opportunistic pathogen Pseudomonas aeruginosa secretes an alkaline protease called AprA that degrades flagellin monomers. Here, we show that AprA is widespread among a wide variety of bacterial species. In addition, we investigated the role of AprA in virulence of the bacterial plant athogen P. syringae pv. tomato DC3000. The AprA-deficient DC3000 ΔaprA knockout mutant was significantl...

  17. Engineering and Directed Evolution of a Ca2+ Binding Site A-Deficient AprE Mutant Reveal an Essential Contribution of the Loop Leu75–Leu82 to Enzyme Activity

    OpenAIRE

    Eliel R. Romero-García; Alfredo Téllez-Valencia; María F. Trujillo; José G. Sampedro; Hugo Nájera; Arturo Rojo-Domínguez; Jesús García-Soto; Mario Pedraza-Reyes

    2009-01-01

    An aprE mutant from B. subtilis 168 lacking the connecting loop Leu75–Leu82 which is predicted to encode a Ca2+ binding site was constructed. Expression of the mutant gene (aprEΔLeu75–Leu82) produced B. subtilis colonies lacking protease activity. Intrinsic fluorescence analysis revealed spectral differences between wild-type AprE and AprEΔL75–L82. An AprEΔL75–L82 variant with reestablished enzyme activity was selected by directed evolution. The no...

  18. Design of a load following controller for APR+ nuclear plants

    International Nuclear Information System (INIS)

    A load-following operation in APR+ nuclear plants is necessary to reduce the need to adjust the boric acid concentration and to efficiently control the control rods for flexible operation. In particular, a disproportion in the axial flux distribution, which is normally caused by a load-following operation in a reactor core, causes xenon oscillation because the absorption cross-section of xenon is extremely large and its effects in a reactor are delayed by the iodine precursor. A model predictive control (MPC) method was used to design an automatic load-following controller for the integrated thermal power level and axial shape index (ASI) control for APR+ nuclear plants. Some tracking controllers employ the current tracking command only. On the other hand, the MPC can achieve better tracking performance because it considers future commands in addition to the current tracking command. The basic concept of the MPC is to solve an optimization problem for generating finite future control inputs at the current time and to implement as the current control input only the first control input among the solutions of the finite time steps. At the next time step, the procedure to solve the optimization problem is then repeated. The support vector regression (SVR) model that is used widely for function approximation problems is used to predict the future outputs based on previous inputs and outputs. In addition, a genetic algorithm is employed to minimize the objective function of a MPC control algorithm with multiple constraints. The power level and ASI are controlled by regulating the control banks and part-strength control banks together with an automatic adjustment of the boric acid concentration. The 3-dimensional MASTER code, which models APR+ nuclear plants, is interfaced to the proposed controller to confirm the performance of the controlling reactor power level and ASI. Numerical simulations showed that the proposed controller exhibits very fast tracking responses.

  19. Review of APR+ Level 2 PSA. Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    Lehner, John R. [Brookhaven National Lab. (BNL), Upton, NY (United States); Mubayi, Vinod [Brookhaven National Lab. (BNL), Upton, NY (United States); Pratt, W. Trevor [Brookhaven National Lab. (BNL), Upton, NY (United States); Kim, Do Sam [Korea Institute of Nuclear Safety (KINS), Daejeon (Korea, Republic of); Cho, Yong Jin [Korea Institute of Nuclear Safety (KINS), Daejeon (Korea, Republic of); Cho, Sang Jin [Korea Institute of Nuclear Safety (KINS), Daejeon (Korea, Republic of); Kim, In Goo [Korea Institute of Nuclear Safety (KINS), Daejeon (Korea, Republic of)

    2012-02-17

    Brookhaven National Laboratory (BNL) assisted the Korea Institute of Nuclear Safety (KINS) in reviewing the Level 2 Probabilistic Safety Assessment (PSA) of the APR+ Advanced Pressurized Water Reactor (PWR) prepared by the Korea Hydro & Nuclear Power Co., Ltd (KHNP) and KEPCO Engineering & Construction Co., Inc. (KEPCO-E&C). The work described in this report involves a review of the APR+ Level 2 PSA submittal [Ref. 1]. The PSA and, therefore, the review is limited to consideration of accidents initiated by internal events. As part of the review process, the review team also developed three sets of Requests for Additional Information (RAIs). These RAIs were provided to KHNP and KEPCO-E&C for their evaluation and response. This final detailed report documents the review findings for each technical element of the PSA and includes consideration of all of the RAIs made by the reviewers as well as the associated responses. This final report was preceded by an interim report [Ref. 2] that focused on identifying important issues regarding the PSA. In addition, a final meeting on the project was held at BNL on November 21-22, 2011, where BNL and KINS reviewers discussed their preliminary review findings with KHNP and KEPCO-E&C staffs. Additional information obtained during this final meeting was also used to inform the review findings of this final report. The review focused not only on the robustness of the APR+ design to withstand severe accidents, but also on the capability and acceptability of the Level 2 PSA in terms of level of detail and completeness. The Korean nuclear regulatory authorities will decide whether the PSA is acceptable and the BNL review team is providing its comments for KINS consideration. Section 2.0 provides the basis for the BNL review. Section 3.0 presents the review of each technical element of the PSA. Conclusions and a summary are presented in Section 4.0. Section 5.0 contains the references.

  20. Design of a Load Following Controller for APR+ Nuclear Plants

    International Nuclear Information System (INIS)

    The load-following operation of an APR+ nuclear plants is required to restrain the adjustment of boric acid concentration and to efficiently control the control rods for the flexibility of the operation. Especially, axial flux distribution disproportion that is usually caused by load-following operation in a reactor core induces xenon oscillation because the absorption cross-section of xenon is extremely large and its effects in a reactor are delayed by the iodine precursor. Rapid and smooth power maneuvering has its benefits in view of the economical and safe operation of reactors, so it is required that the controller is efficiently designed. Therefore, the load-following operation of an APR+ nuclear plants needs the ultimate automatic control and the advanced control method that satisfies the conditions such as the flexibility, safety and convenience. A model predictive control (MPC) method is applied to design an automatic load-following controller for the integrated thermal power level and axial shape index (ASI) control for an APR+ nuclear plants. Some tracking controllers use only the current tracking command. On the other hand, since MPC considers future commands in addition to the current tracking command, the MPC can achieve better tracking performance. Therefore, the MPC has been applied very much to the control of industrial process systems. The basic concept of the MPC is to solve an optimization problem for generating finite future control inputs at current time and to implement as the current control input only the first control input among the solutions of the finite time steps. At the next time step, the second control input is not implemented and the procedure to solve the optimization problem is then repeated. The power level and the ASI are controlled by the regulating control banks and part-strength control banks together with the automatic adjustment of boric acid concentration. The 3-dimensional MASTER code, which models the APR+ nuclear

  1. Pseudomonas syringae evades host immunity by degrading flagellin monomers with alkaline protease AprA.

    Science.gov (United States)

    Pel, Michiel J C; van Dijken, Anja J H; Bardoel, Bart W; Seidl, Michael F; van der Ent, Sjoerd; van Strijp, Jos A G; Pieterse, Corné M J

    2014-07-01

    Bacterial flagellin molecules are strong inducers of innate immune responses in both mammals and plants. The opportunistic pathogen Pseudomonas aeruginosa secretes an alkaline protease called AprA that degrades flagellin monomers. Here, we show that AprA is widespread among a wide variety of bacterial species. In addition, we investigated the role of AprA in virulence of the bacterial plant pathogen P. syringae pv. tomato DC3000. The AprA-deficient DC3000 ΔaprA knockout mutant was significantly less virulent on both tomato and Arabidopsis thaliana. Moreover, infiltration of A. thaliana Col-0 leaves with DC3000 ΔaprA evoked a significantly higher level of expression of the defense-related genes FRK1 and PR-1 than did wild-type DC3000. In the flagellin receptor mutant fls2, pathogen virulence and defense-related gene activation did not differ between DC3000 and DC3000 ΔaprA. Together, these results suggest that AprA of DC3000 is important for evasion of recognition by the FLS2 receptor, allowing wild-type DC3000 to be more virulent on its host plant than AprA-deficient DC3000 ΔaprA. To provide further evidence for the role of DC3000 AprA in host immune evasion, we overexpressed the AprA inhibitory peptide AprI of DC3000 in A. thaliana to counteract the immune evasive capacity of DC3000 AprA. Ectopic expression of aprI in A. thaliana resulted in an enhanced level of resistance against wild-type DC3000, while the already elevated level of resistance against DC3000 ΔaprA remained unchanged. Together, these results indicate that evasion of host immunity by the alkaline protease AprA is important for full virulence of strain DC3000 and likely acts by preventing flagellin monomers from being recognized by its cognate immune receptor. PMID:24654978

  2. Quality Control of Concrete Structure For APR1400 Construction

    International Nuclear Information System (INIS)

    Nuclear structure shall be constructed to protect internal facilities in the normal operation against external accidents such as the radiation shielding, earthquakes and to be leak-proof of radioactive substances to the external environment in case of loss of coolants. containment and auxiliary building of nuclear power plants are built in reinforced concrete structures to maintain these protection functions. Nuclear structures shall be designed to ensure soundness in operation since they are located on the waterfront where is easy do drain the cooling water and so deterioration and damage of concrete structures caused by seawater can occur. Durability is ensured for concrete structures of APR1400, a Korea standard NPP, in compliance with all safety requirements. In particular, owners perform quality control directly on the production and pouring of cast in place concrete for the concrete structure construction to make sure concrete structures established with quality homogeneity and durability. This report is to look into the quality control standard and management status of cast in place concrete for APR1400 construction

  3. Severe Accident Management Strategy for EU-APR1400

    International Nuclear Information System (INIS)

    In EU-APR1400, the dedicated instrumentation and mitigation features for SAM are being developed to keep the integrity of containment and to prevent the uncontrolled release of fission products. In this paper, SAM strategy for EU-APR1400 was introduced in stages. It is still under development and finally the Severe Accident Management Guidance will be completed based on this SAM Strategy. Severe accidents in a nuclear power plant are defined as certain unlikely event sequences involving significant core damage with the potential to lead to significant releases according to EUR 2.1.4.4. Even though the probability of severe accidents is extremely low, the radiation release may cause serious effect on people as well as environment. Severe Accident Management (SAM) encompasses those actions which could be considered in recovering from a severe accident and preventing or mitigating the release of fission products to the environment. Whether those actions are successful or not, depending on a progression status of a severe accident to mitigate the consequences of severe accident phenomena to limit the release of radioactive materials keeping the leak tightness of the Primary Containment, and finally to restore transient severe accident progression into a controlled and safe states

  4. Analysis on the Direct Vessel Injection Line Break Accident at APR+ Standard Design

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Youngho; Yang, Huichang [TUEV Rheinland Korea Ltd., Seoul (Korea, Republic of); Kim, Kap [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2013-10-15

    APR+ (Advanced Power Reactor +) is the newest design variation of APR1400. The main characteristics of APR+, compared with APR1400, are passive safety systems and dedicated systems for severe accident mitigation. APR+ is under review for standard design certification. In this study, thermal hydraulic analysis on the Direct Vessel Injection (DVI) line break accident postulated in APR+ design was performed. Comparisons of the major parameters which can represent the overall accident behavior during DVI line break accident, several discrepancies between this study and reference data were found and such discrepancies include actuation timing of SIPs and SITs, and also include parameter behaviors of break flow rate and PCT at the accident initiation. These differences were mainly from the different thermal hydraulic models in simulation codes. The behavioral differences for break flow as well as peak cladding temperatures will be examined further as a next step for this study.

  5. Performance validation of advanced safety features of APR

    International Nuclear Information System (INIS)

    This paper briefly introduces recent progress, which is mainly being performed at KAERI, in design and performance validation tests of advanced safety features for the APR+ (Advanced Power Reactor plus). The main safety technologies included in the APR+ standard design improvement are an advanced Direct Vessel Injection Plus (DVI+), Fluidic Device Plus (FD+), and Passive Auxiliary Feedwater System (PAFS). The validation tests of advanced safety features are performed using scaled down model testes. They include: 1/5-Scale air-water test, DVI+ duct vibration test, full scale duct injection test, 1/240-Scale PAFS separate effect test, and ATLAS-PAFS integral effect test. The other design verification tests are also performed. They include: Full scale 3-Fuel assembly cross flow test, 1/5-Scale reactor flow distribution test (to be performed, under construction), Core simulator calibration developing test for core flow test, Full scale advanced Fluidic Device (FD+), CEDM test-to be performed, and IVR and core capture test. The core flow and reactor flow tests are being performed by both experimental and CFD (Computational Fluid Dynamics) analysis for the test facility development. The ECC bypass test is performed using 1/5-scale air-water test facility. The duct test facility. The 1/5-scale core barred vibration test with DVI duct is also performed under the both wet and dry condition. The design goal of PAFS is replacing an auxiliary feedwater system with a passive Steam Generator (SG) secondary cooling system of APR+. In PAFS, the core decay heat is ideogram in the Passive Condensation Cooling Tank (PCCT). The PCCT is located on the top of Auxiliary building. To validate the cooling performance of PAFS, a separate effect test loop has been constructed at KAERI (Korea Atomic Energy Research Institute), which is named PASCAL (PAFS Condensing heat removal Assessment Loop). To quantify the tube heat transfer coefficient of the horizontal heat exchanger, a full scale

  6. Écrire (d’après

    Directory of Open Access Journals (Sweden)

    Denis Saint-Amand

    2009-03-01

    Full Text Available De l’allusion à la citation, de l’emprunt criard au plagiat déguisé, les jeux d’influences et d’aller-retour avec tel ou tel modèle, grand ou mineur, ont toujours participé de l’élaboration du texte littéraire. Si l’intertextualité est sans aucun doute née en même temps que l’écriture (ou quelques minutes après et que, comme ont pu le montrer notamment Jacques-Philippe Saint-Gérand et Daniel Sangsue, les facettes multiples qu’elle déploie ont toujours suscité l’attention des hommes de lettre...

  7. Écrire (d’)après

    OpenAIRE

    Denis Saint-Amand

    2009-01-01

    De l’allusion à la citation, de l’emprunt criard au plagiat déguisé, les jeux d’influences et d’aller-retour avec tel ou tel modèle, grand ou mineur, ont toujours participé de l’élaboration du texte littéraire. Si l’intertextualité est sans aucun doute née en même temps que l’écriture (ou quelques minutes après) et que, comme ont pu le montrer notamment Jacques-Philippe Saint-Gérand et Daniel Sangsue, les facettes multiples qu’elle déploie ont toujours suscité l’attention des hommes de lettre...

  8. 14 CFR Appendix H to Part 23 - Installation of An Automatic Power Reserve (APR) System

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Installation of An Automatic Power Reserve (APR) System H Appendix H to Part 23 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT... AIRPLANES Pt. 23, App. H Appendix H to Part 23—Installation of An Automatic Power Reserve (APR) System...

  9. Pseudomonas syringae evades host immunity by degrading flagellin monomers with alkaline protease AprA

    NARCIS (Netherlands)

    Pel, Michiel J C; van Dijken, Anja J H; Bardoel, Bart W; Seidl, Michael F; van der Ent, Sjoerd; van Strijp, Jos A G; Pieterse, Corné M J

    2014-01-01

    Bacterial flagellin molecules are strong inducers of innate immune responses in both mammals and plants. The opportunistic pathogen Pseudomonas aeruginosa secretes an alkaline protease called AprA that degrades flagellin monomers. Here, we show that AprA is widespread among a wide variety of bacteri

  10. Pseudomonas syringae evades host Immunity by degrading flagellin monomers with alkaline protease AprA

    NARCIS (Netherlands)

    Pel, M.J.C.; Van Dijken, A.J.H.; Bardoel, B.W.; Seidl, M.F; Van der Ent, S.; Van Strijp, J.A.G.

    2014-01-01

    Bacterial flagellin molecules are strong inducers of innate immune responses in both mammals and plants. The opportunistic pathogen Pseudomonas aeruginosa secretes an alkaline protease called AprA that degrades flagellin monomers. Here, we show that AprA is widespread among a wide variety of bacteri

  11. Thermal-hydraulic Analysis of SGTR for Supporting PSA in APR+

    International Nuclear Information System (INIS)

    The Advanced Power Reactor Plus (APR+) is being developed in Korea. To enhance the safety of the APR+, a passive auxiliary feedwater system (PAFS) has been adopted in the APR+. The PAFS completely replaces the conventional active auxiliary feedwater system (AFWS). It is operated by a natural driving force mechanism when demanding auxiliary feedwater. It could maintain the system function of cooling the primary side and remove the decay heat while operated PAFS. For estimating the safety of APR+ design, the probabilistic safety assessment (PSA) of APR+ is performed. As the PAFS replaces the conventional AFWS, it is required to verify the cooling capacity of PAFS for the accurate evaluation. For this reason, this paper discusses the cooling performance of the PAFS while transient accidents

  12. An ATWS Analysis for EU-APR1400 Following the European Utility Requirement

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Minshin; Lee, Cheolshin; Sohn, Jongjoo [KEPCO Engineering and Construction Company., Inc., Daejeon (Korea, Republic of)

    2013-05-15

    This paper presents the results of the evaluation of the ATWS events with respect to Reactor Coolant System (RCS) overpressure and re-criticality for the European APR1400 (EU-APR1400) according to European Utility Requirement (EUR). This paper evaluates the ATWS impact on the EU-APR1400 by applying EUR. Based on the results of safety analysis for ATWS events, all the acceptance criteria for EUR can be satisfied due to the proper functioning of ATWS mitigation systems. However the four events are investigated only in this paper, and hence the results of this paper can not be concluded that the EU-APR1400 design satisfy all requirements for the EUR. Therefore, a further study for all Design Basis Event Category 2 (DBC2) events with ATWS needs to be performed in order to assess the comprehensive impact of ATWS events for the EU-APR1400 design.

  13. Development of Core Simulator (CoSi) for APR1400 And Analysis of LPPT Result using APR1400-CoSi

    Energy Technology Data Exchange (ETDEWEB)

    Moon, Sang-Rae; Kim, Yong-Bae; Lee, Eun-Ki [KHNP-CRI, Daejeon (Korea, Republic of)

    2014-10-15

    According to NRC guidelines, Low Power Physics Test (LPPT) is required to be performed in low temperature/low pressure (160 .deg. C/42.2 kg/cm{sup 2}) as well as NOT/NOP (291.3 .deg. C/158.2 kg/cm{sup 2}) because Shin-Kori Unit 3 is FOAK nuclear power plant. Low Power Physics Test (LPPT) is essential to verify the nuclear design and robustness of reactor safety. LPPT consists of initial criticality, Point of Adding Heat (POAH), All Rod Out (ARO) Boron Concentration, Isothermal Temperature Coefficient (ITC), Control Rod Worth measurements and so on. KHNP-CRI has developed the Core Simulator for APR1400 (APR1400-CoSi) in order to improve the ability performing the LPPT. Especially, APR1400-CoSi has enhanced capability to calculate the full Core neutronic parameters by revising RAST-K that is three dimensional real time core kinetic program. APR1400-CoSi has been developed for education-training of Low Power Physics Test(LPPT). Particularly, APR1400-CoSi has an enhanced capability to calculate the full core neutronic parameters by revising RAST-K which is a three dimensional real time core kinetics program. Low Power Physics Test (LPPT) was performed using APR1400-CoSi and the results showed very similar values with the predicted ones. In other words, the initial core model of Shin-Kori Unit 3 in APR1400-CoSi system has been verified to be appropriate enough. Also, it was confirmed that the test range of Low Power Physics Test (LPPT) reamains effective even though the largest incremental bank reactivity is inserted in core by analyzing the power change during the rod SWAP test.

  14. Development of Core Simulator (CoSi) for APR1400 And Analysis of LPPT Result using APR1400-CoSi

    International Nuclear Information System (INIS)

    According to NRC guidelines, Low Power Physics Test (LPPT) is required to be performed in low temperature/low pressure (160 .deg. C/42.2 kg/cm2) as well as NOT/NOP (291.3 .deg. C/158.2 kg/cm2) because Shin-Kori Unit 3 is FOAK nuclear power plant. Low Power Physics Test (LPPT) is essential to verify the nuclear design and robustness of reactor safety. LPPT consists of initial criticality, Point of Adding Heat (POAH), All Rod Out (ARO) Boron Concentration, Isothermal Temperature Coefficient (ITC), Control Rod Worth measurements and so on. KHNP-CRI has developed the Core Simulator for APR1400 (APR1400-CoSi) in order to improve the ability performing the LPPT. Especially, APR1400-CoSi has enhanced capability to calculate the full Core neutronic parameters by revising RAST-K that is three dimensional real time core kinetic program. APR1400-CoSi has been developed for education-training of Low Power Physics Test(LPPT). Particularly, APR1400-CoSi has an enhanced capability to calculate the full core neutronic parameters by revising RAST-K which is a three dimensional real time core kinetics program. Low Power Physics Test (LPPT) was performed using APR1400-CoSi and the results showed very similar values with the predicted ones. In other words, the initial core model of Shin-Kori Unit 3 in APR1400-CoSi system has been verified to be appropriate enough. Also, it was confirmed that the test range of Low Power Physics Test (LPPT) reamains effective even though the largest incremental bank reactivity is inserted in core by analyzing the power change during the rod SWAP test

  15. Implementation of Low Boron Core for APR1400 Initial Cycle

    International Nuclear Information System (INIS)

    Low boron capability of a nuclear power plant is rather a qualitative specification requiring the nuclear power plant to be shut down by control rods alone at any time of a plant cycle according to EUR. The reduction of soluble boron is beneficial since it gives the reduction of the corrosive effects in the plant system and improves plant safety giving more negative MTC. Thus, it is necessary to reduce the amount of soluble boron for the criticality to achieve the low boron capability. However, the reduction of soluble boron has its own set of specific challenges that must be overcome. There are two methods to enable the reduction of soluble boron without modifying plant system significantly. The goal of this study is to investigate the loading pattern to achieve the soluble boron reduction for Shin-Kori Unit 5 APR1400 initial core using the low and high content gadolinia burnable absorbers with standard fuel rod enrichment and to verify the feasibility of low boron core with conventional gadolinia burnable absorbers only. For this study, KARMA has been employed to solve 2-D Transport equation, and ASTRA is used for full core analysis. It was possible to achieve the low boron core for APR1400 Cycle 1 using extended usage of two types of gadolinia burnable absorbers sacrificing fuel cycle economy a little bit while enhancing plant safety significantly. Gd rod patterns within an assembly were optimized through geometrical weighting and loading pattern was developed based on these patterns. The amount of soluble boron reduction achieved is 45.4%. The improvement in plant safety is significant resulting in the reduction of least negative best-estimate MTC by about 4 pcm. Also shutdown margin is increased slightly for low boron core. However, the behavior of axial power shape turns out to be undesirable showing a relatively large fluctuation caused by the more negative MTC. It was found that the low boron core might impose kind of operational difficulty. It is usually

  16. Extended Station Blackout Coping Capabilities of APR1400

    Directory of Open Access Journals (Sweden)

    Sang-Won Lee

    2014-01-01

    Full Text Available The Fukushima Dai-ichi nuclear power plant accident shows that an extreme natural disaster can prevent the proper restoration of electric power for several days, so-called extended SBO. In Korea, the government and industry performed comprehensive special safety inspections on all domestic nuclear power plants against beyond design bases external events. One of the safety improvement action items related to the extended SBO is installation of external water injection provision and equipment to RCS and SG. In this paper, the extended SBO coping capability of APR1400 is examined using MAAP4 to assess the effectiveness of the external water injection strategy. Results show that an external injection into SG is applicable to mitigate an extended SBO scenario. However, an external injection into RCS is only effective when RCS depressurization capacity is sufficiently provided in case of high pressure scenarios. Based on the above results, the technical basis of external injection strategy will be reflected on development of revised severe accident management guideline.

  17. APR+ PAFS Cooling Performance Analysis using RELAP5

    International Nuclear Information System (INIS)

    To enhance safety and reliability of nuclear power plant in domestic industry, passive safety system design has been introducing. Especially, passive auxiliary feedwater system (PAFS) has been applied to the advanced power reactor plus (APR+). PAFS is a facility that replaces an active auxiliary feedwater system (AFWS) in the existing plant. The system function is to remove the generating heat of primary system during transient and accidents unless main feedwater system is available. PAFS consists of a passive condensate cooling tank (PCCT), a heat exchanger, valves, and pipes as shown in Fig. 1. PAFS design is considered that its performance ensure the safety function. But it is difficult that the performance of PAFS is determined quantitatively unlike AFWS. Because AFWS can be controlled on its flow and enthalpy but PAFS can't be controlled on them. The characteristic of passive safety system can be changed along transient and accident. Therefore some considerations are required about how to determine the PAFS performance and how to find the conservative condition to evaluate it in respect to transient and accidents

  18. Conceptual design of passive containment cooling system based on APR+

    International Nuclear Information System (INIS)

    The accident of the Fukushima nuclear power plant left a profound message toward the need for a passive cooling system which can operate under the extended station blackout. These days, nuclear institutions in Korea are developing Advanced Power Reactor Plus (APR+). Its distinct characteristic lies on the passive auxiliary feed water system (PAFS) which removes decay heat to a passive condensation cooling tank (PCCT) by natural convection. Though the system is expected to work well under station blackout, the system becomes useless under the loss of coolant accident (LOCA) combined with station blackout. This paper aims at using existing heat exchangers of PAFS and PCCT under LOCA to cool the reactor as well as the containment in a fully passive way. To enhance the condensation rate of heat exchangers in PCCT, we need to produce convective flow in the PCCS heat exchangers. Therefore, the whole region of the concrete containment is divided into 3 chambers: inner, outer, PCCS chambers. An outer chamber is disposed to collect non-condensable gas. The condensate is stored in a condensate storage tank (CST) and injected into the reactor by gravity. This system makes a closed circuit to work indefinitely. A scoping analysis for the containment pressure is performed as a function of various parameters: outer chamber volume and number of tubes in heat exchangers. (author)

  19. Modal analysis of an ECC duct for APR+ reactor barrel

    International Nuclear Information System (INIS)

    Advanced Power Reactor Plus (APR+) provides four Direct Vessel Injection (DVI) ducts on the reactor barrel to enhance the performance of Emergency Core Cooling System (ECCS). Several studies on safety analysis have verified the excellent performance of the DVI duct. In this study, from the viewpoint of mechanical integrity, modal analyses of two full-scaled DVI ducts have been presented; both numerical analysis and modal tests have been performed in air and water. It was found that the numerical simulation and modal test coincide with each other. The DVI duct is a thin shell of 5 mm thickness, so that harmonic responses to RCP blade passing frequencies should be checked. The dominant passing frequencies are known to be 20, 40, 60, 120 and 240 Hz. In addition, an interesting thing in this study is that added mass effect by coolant seems to be so significant that the natural frequency of the ducts under water could be considerably low as compared with those in air; the natural frequency under water is 60 % lower than that in air. (author)

  20. Verification of SAMG entry condition for APR1400

    Energy Technology Data Exchange (ETDEWEB)

    Yun, Junghyun; Kim, Taewan; Kim, Jonghyun [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

    2013-10-15

    In the wake of the Fukushima accident, severe accident management has become important more than ever. While Emergency Operating Procedures (EOPs) focuses on cooling down the core during a design basis accident, the prime objective of severe accident management guideline (SAMG) is to prevent the release of radioactive material into the environment during a severe accident. Only one fixed value of core exit temperature (CET) has been applied for several decades to different types of nuclear power plants (NPPs) in Korea. Although the different types of NPPs have different cladding materials and system designs, the identical CET, i. e., 650 .deg. C, is applied as the entry condition to the SAMG of all the NPPs (except CANDU plants), i. e., Westinghouse type, OPR1000, and APR1400. In this paper, the transition point is re-evaluated for dominant severe accident sequences; station black-out (SBO), small break loss of coolant accident (SBLOCA), and me dium break loss of coolant accident (MBLOCA). In cases of SBO and SBLOCA, the current SAMG entry condition seems proper, while it needs to be reconsidered for MBLOCA case.

  1. APR+ PAFS Cooling Performance Analysis using RELAP5

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyung Jin; Hong, Soon Joon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2011-05-15

    To enhance safety and reliability of nuclear power plant in domestic industry, passive safety system design has been introducing. Especially, passive auxiliary feedwater system (PAFS) has been applied to the advanced power reactor plus (APR+). PAFS is a facility that replaces an active auxiliary feedwater system (AFWS) in the existing plant. The system function is to remove the generating heat of primary system during transient and accidents unless main feedwater system is available. PAFS consists of a passive condensate cooling tank (PCCT), a heat exchanger, valves, and pipes as shown in Fig. 1. PAFS design is considered that its performance ensure the safety function. But it is difficult that the performance of PAFS is determined quantitatively unlike AFWS. Because AFWS can be controlled on its flow and enthalpy but PAFS can't be controlled on them. The characteristic of passive safety system can be changed along transient and accident. Therefore some considerations are required about how to determine the PAFS performance and how to find the conservative condition to evaluate it in respect to transient and accidents

  2. Study on Maintenance Personnel Development Plan For The Exported APR1400 Commissioning

    International Nuclear Information System (INIS)

    This paper indicates ways to develop maintenance personnel for the exported APR1400 commissioning. The exported APR1400 has not been experienced ay maintenance yet, and requirements for maintenance personnel have not been clarified yet. Based on sound maintenance experience, KEPCO Plant Service and Engineering Company (KEPCO KPS) has studied on maintenance training and career requirement to establish a development plan of the maintenance personnel for the exported nuclear power plant. By defining manpower and training requirement, and mobilization plan, we expect to secure reliability of the exported APR1400

  3. Current status of integrated HFE V and V system of APR1400

    International Nuclear Information System (INIS)

    The first Advanced Light Water Reactor called Advanced Power Reactor (APR1400) has many specific features such as passive safety features, digital I and C, and digitalized main control room design. This digital-based neo-concept main control room design needs comprehensive verification and validation process to get the license for construction. An integrated system for APR1400 MMIS design validation is under development by KEPRI with the participating of KHNP. The facility which is based on the NUREG/CR-6393 and ANS3.5 can simulate all of the dynamic functions and responses of APR1400, and measure the human factors by using conventional subject methods and measuring the operator's biological signals. This system will be used in human factors V and V process of the PRM (NUREG0711) of APR1400 MMIS design. (authors)

  4. COMENTARIU LA ARTICOLUL FISTULE CHOLÉCYSTO - DUODÉNALE E. Christide - Revista de Chirurgie 1938; 7 - 8/41: 579 - 585

    Directory of Open Access Journals (Sweden)

    Nicolae M. Constantinescu

    2012-11-01

    dispoziţie: avivareamarginilor cu sutură transversală în 2planuri, patch cu seroasă de jejun,anastomoză duodeno-jejunală latero-terminală pe ansă în Y Roux. În cazul unuiduoden II strâmtorat se poate executa ogastroentero-anastomoză.Articolul pe care îl comentez şidiscuţiile pe care le-a suscitat la Societateade Chirurgie din Bucureşti în urmă cu treisferturi de secol ne aduc în memorie 4 dinmarii chirurgi ai primei jumătăţi a sec XX.Astfel în spatele lui Christide îlvedem peingeniosul Ernest Juvara, chiar dacă la oraaceea nu mai era în viaţă, bolnavul prezentatde St.Jianu a fost rezolvat de IacobIacobovici, cazul prezentat de Blassian a fostoperat de Traian Nasta iar cel comentat deGh. Gatoschi a fost operat deVladimirBuţureanu la Iaşi.Observaţia clinică a lui Christide areca particularităţi istoricul care precizeazăeliminarea de calculi prin fecale, semn carenu este patognomonic pentru fistulă-şi apoimaniera în care a folosit perete din colecistpentru aacoperi defectul duodenal. Pentrupolul biliar nu a făcut nici o manevră deidentificare şi ligatură a canalului cistic,motiv care explică biliragia postoperatorie,care a durat cu intermitenţă patru luni şiAdresa de corespondenţă: Prof.Dr.N.M. ConstantinescuUniversitatea de Medicină şi Farmacie „Carol Davila” Bucureştie-mail: nae_constantinescu@yahoo.com412Jurnalulde Chirurgie (Iaşi, 2012, Vol. 8, Nr. 4jumătate. Actualmente cazul ar fi beneficiatmult mai devreme de o papilo-sfincterotomieendoscopică.În cazul prezentat de Ştefan Jianu eravorba de o fistulă ulceroasă colecisto-duodenală între fundul colecistului şigenunchiul superior duodenal, la caregastrectomia cu anastomoză gastro-jejunalăapus în repaus fistula de contactul cualimente, lucru pe care nu-l reuşise GEAefectuată anterior şi care se dovedisenefuncţională.Bolnavul prezentat de Blassian şi carea fost operat de Traian Nasta este un caztipic de fistulă colecisto-duodenală deorigine

  5. Development of human factors validation system for the advanced control room of APR1400

    International Nuclear Information System (INIS)

    A human factors validation system for the main control room (MCR) of Advanced Power Reactor 1400 MWe (APR1400) has been developed as it adopts digitalized human-system interfaces (HSIs). The integrated validation system is composed of process/plant models, HSIs, and the human performance evaluation support system (HUPESS). A real-time thermal-hydraulic code, RELAP5 R/T, was used and modified to simulate the dynamic characteristics of the APR1400, and simulation software, 3KeyMaster, was used to model the balance of plant systems. The HSIs developed in this study include all facilities in the APR1400 MCR, such as large display panels, 3 identified operator workstations, and a safety console. In addition, the remote shutdown workstation has been developed. The display systems in the HSIs have been developed using ProcSee, which is a software tool for developing and displaying dynamic graphical user interfaces. This paper describes the configurations of HSIs including display systems, the dynamic models of the APR1400 simulator, the instructor station, and the HUPESS. This paper also presents the results of plant simulation performance tests at transient compared with the results of RELAP5/MOD3.3 calculations. The human factors validation system for the advanced control room of APR1400 provides high degrees of physical, functional, and dynamic fidelities, and can be used in the validation process of the APR1400 HSI design. (author)

  6. Reliability enhancement of APR + diverse protection system regarding common cause failures

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Y. G.; Kim, Y. M.; Yim, H. S. [KEPCO Engineering and Construction Company, Inc., 1045 Daedeok-Daero, Yuseong-gu, Daejeon 305-353 (Korea, Republic of); Lee, S. J. [Chungnam National Univ., 99 Daehak-ro, Yuseong-gu, Daejeon 305-764 (Korea, Republic of)

    2012-07-01

    The Advanced Power Reactor Plus (APR +) nuclear power plant design has been developed on the basis of the APR1400 (Advanced Power Reactor 1400 MWe) to further enhance safety and economics. For the mitigation of Anticipated Transients Without Scram (ATWS) as well as Common Cause Failures (CCF) within the Plant Protection System (PPS) and the Emergency Safety Feature - Component Control System (ESF-CCS), several design improvement features have been implemented for the Diverse Protection System (DPS) of the APR + plant. As compared to the APR1400 DPS design, the APR + DPS has been designed to provide the Safety Injection Actuation Signal (SIAS) considering a large break LOCA accident concurrent with the CCF. Additionally several design improvement features, such as channel structure with redundant processing modules, and changes of system communication methods and auto-system test methods, are introduced to enhance the functional reliability of the DPS. Therefore, it is expected that the APR + DPS can provide an enhanced safety and reliability regarding possible CCF in the safety-grade I and C systems as well as the DPS itself. (authors)

  7. Reliability enhancement of APR + diverse protection system regarding common cause failures

    International Nuclear Information System (INIS)

    The Advanced Power Reactor Plus (APR +) nuclear power plant design has been developed on the basis of the APR1400 (Advanced Power Reactor 1400 MWe) to further enhance safety and economics. For the mitigation of Anticipated Transients Without Scram (ATWS) as well as Common Cause Failures (CCF) within the Plant Protection System (PPS) and the Emergency Safety Feature - Component Control System (ESF-CCS), several design improvement features have been implemented for the Diverse Protection System (DPS) of the APR + plant. As compared to the APR1400 DPS design, the APR + DPS has been designed to provide the Safety Injection Actuation Signal (SIAS) considering a large break LOCA accident concurrent with the CCF. Additionally several design improvement features, such as channel structure with redundant processing modules, and changes of system communication methods and auto-system test methods, are introduced to enhance the functional reliability of the DPS. Therefore, it is expected that the APR + DPS can provide an enhanced safety and reliability regarding possible CCF in the safety-grade I and C systems as well as the DPS itself. (authors)

  8. Engineering and Directed Evolution of a Ca2+ Binding Site A-Deficient AprE Mutant Reveal an Essential Contribution of the Loop Leu75–Leu82 to Enzyme Activity

    Directory of Open Access Journals (Sweden)

    Eliel R. Romero-García

    2009-01-01

    Full Text Available An aprE mutant from B. subtilis 168 lacking the connecting loop Leu75–Leu82 which is predicted to encode a Ca2+ binding site was constructed. Expression of the mutant gene (aprEΔLeu75–Leu82 produced B. subtilis colonies lacking protease activity. Intrinsic fluorescence analysis revealed spectral differences between wild-type AprE and AprEΔL75–L82. An AprEΔL75–L82 variant with reestablished enzyme activity was selected by directed evolution. The novel mutations Thr66Met/Gly102Asp located in positions which are predicted to be important for catalytic activity were identified in this variant. Although these mutations restored hydrolysis, they had no effect with respect to thermal inactivation of AprEΔL75–L82  T66M  G102D. These results support the proposal that in addition to function as a calcium binding site, the loop that connects β-sheet e3 with α-helix c plays a structural role on enzyme activity of AprE from B. subtilis 168.

  9. Economics enhancement of APR1400 through the application of new construction methods

    International Nuclear Information System (INIS)

    The development of APR1400 (formerly KNGR) project is one of Korea's national G-7 projects, sponsored by the government and KHNP (Korea Hydro and Nuclear Power Co., Ltd.). APR1400, an evolutionary standard reactor with a thermal output of 4000MWt, upgrades the safety and economic competitiveness of nuclear power, incorporating cutting-edge advanced technologies, while standing on the proven experience of Optimized Power Reactor 1000(OPR1000, formerly KSNP) design. APR1400 has been adopted as the design for Shin-Kori Units 3 and 4. APR1400 development project consisted of three phases in order to check and make only necessary adjustments at the end of each phase and the standard design certification (DC) was issued in May 2002. The project set up the top-tier requirements for the design's safety, economy, operability, maintainability, and construct ability in the earliest design stage. The requirements have been evaluated periodically during the design process, and the results of each evaluation were reflected in the final design. Shin-Kori Units 3 and 4 are the first APR1400 projects, and will be built near the Kori NPP site, where four units are currently in operation and two OPR1000 (Improved Korean Standard Nuclear Power Plant) units called Shin-Kori Units 1 and 2 are under construction. Shin-Kori Units 3 and 4 will be constructed based on APR1400 standardized design, while incorporating the site characteristics and construction and operation experiences of OPR1000. This paper describes new construction methods to improve economics and construct ability of APR1400 to meet the target schedule, which is set to 41.5 months from the first concrete pouring to the fuel loading for the Nth plant. The new construction methods consist of 'Open Top Method' for installation of major NSSS equipment, 'Large Modularization' for the Building Structures, Reactor Vessel Internals and Major Components and deck plate method, etc

  10. Experimental and MARS code simulation of DVI line 25% and 50% break LOCAs using SNUF for APR1400

    International Nuclear Information System (INIS)

    APR1400, is an evolutionary PWR (Pressurized Water Reactor) based on the well-proven OPR1000 design. The APR1400 has adopted DVI (Direct Vessel Injection) system instead of CLI (Cold Leg Injection) system as advanced safety features of ECCS (Emergency Core Cooling System). The configuration of the improved ECCS in the APR1400 is completely different from that in the OPR1000 in which pipes for the safety water injection are connected to the cold leg. In APR1400, the safety water injection pipes are directly connected to the RPV (Reactor Pressure Vessel). Thus, the safety water injection system in the APR1400 is called the DVI (Direct Vessel Injection) system. Moreover, safety water injections by the HPSI (High Pressure Safety Injection) pumps are mechanically separately in the APR1400.

  11. GOTHIC Simulation of APR1400 Auxiliary Charging Pump room heat up

    Energy Technology Data Exchange (ETDEWEB)

    Ha, Hui-Un; Heo, Sun [KHNP, Daejeon (Korea, Republic of)

    2014-10-15

    As a part of the Advanced Power Reactor 1400 (APR1400) U. S. Nuclear Regulatory Commission Design Certification (NRC DC) project, we have been investigating Auxiliary Charging Pump (ACP) room heat up. With reference to the design specification of the ACP room, we determined input information and developed a GOTHIC model of the APR1400 ACP room. This calculation model is described herein, and representative results from the calculation are presented as well. The results of the present paper are used to determine the integrity of ACP operating in the accident. APR 1400 GOTHIC model was developed for ACP room heat up calculation. Calculation results confirm that door opening is cooling the room properly. It is found that the difference due to the surface option of heat conductors is insignificant. Based on this result, further studies should be performed to confirm integrity of ACP.

  12. Evaluation of ex-vessel steam explosion load for APR1400 using IFCI

    International Nuclear Information System (INIS)

    The load of ex-vessel steam explosion for APR1400 is evaluated using the IFCI 6.0 code developed by US NRC. The IFCI code is applied to analyse the FCI experiments of FARO-28, KROTOS-44 and TROI-13 as a code V/V process. The load of ex-vessel steam explosion for APR1400 is calculated based on the conditions applied during the code V/V and the load was compared with the analysis result of licence. The IFCI analysis result shows that the integrity of cavity might not be guaranteed once a steam explosion occurs and the result is in contrast with that of licence

  13. The Alberta Pregnancy Outcomes and Nutrition (APrON) cohort study : rationale and methods

    NARCIS (Netherlands)

    Kaplan, Bonnie J.; Giesbrecht, Gerald F.; Leung, Brenda M. Y.; Field, Catherine J.; Dewey, Deborah; Bell, Rhonda C.; Manca, Donna P.; O'Beirne, Maeve; Johnston, David W.; Pop, Victor J.; Singhal, Nalini; Gagnon, Lisa; Bernier, Francois P.; Eliasziw, Misha; McCargar, Linda J.; Kooistra, Libbe; Farmer, Anna; Cantell, Marja; Goonewardene, Laki; Casey, Linda M.; Letourneau, Nicole; Martin, Jonathan W.

    2014-01-01

    The Alberta Pregnancy Outcomes and Nutrition (APrON) study is an ongoing prospective cohort study that recruits pregnant women early in pregnancy and, as of 2012, is following up their infants to 3 years of age. It has currently enrolled approximately 5000 Canadians (2000 pregnant women, their offsp

  14. Assessment of Capability of MARS Code for Safety Evaluation of APR+ PAFS

    International Nuclear Information System (INIS)

    In South Korea, advanced power reactor plus (APR+), as a Korean specific reactor, is currently under development for the export strategy. In order to raise competitiveness of the APR+ in the world market, it is necessary to develop the original technology for the improved technology, economics, and safety features. For this purpose, a passive auxiliary feedwater system (PAFS) was adopted as an improved safety design concept of APR+: and then there have been many efforts to develop the PAFS. According to PAFS design concept, PAFS can completely replace the auxiliary feedwater system. When the design basis accident, in which feedwater is not available, occurs, the PAFS can remove the residual heat in the core and then prevent the core damage. In order to develop the safety evaluation system for APR+ PAFS, it is required to assess the calculation capability of MARS code for the passive system with the horizontal type heat exchanger. For this purpose, the main contents of this study are: 1) to simulate the TH phenomena such as natural circulation and horizontal condensation heat transfer in NOKO experiment using MARS-KS, 2) to compare the simulation results between RELAP5 and MARS for PAFS input model

  15. CFD Simulation of Acoustic-Induced Vibration in Main Steam Line of APR1400

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Sang Gyu; Kim, Tae Jun; Kim, Han Gon [Korea Hydro and Nuclear Power, Daejeon (Korea, Republic of)

    2012-05-15

    In recently, many boiling water reactors (BWRs) implement extended power uprate (EPU) to increase economic benefits. After EPU, Quad Cities power plant has been experienced damage of steam dryers due to acoustic-induced vibration. Acoustic resonance is produced by the interaction between the sound field and an unstable shear layer when the dry steam flows across the closed branch pipes such as safety relief valve(SRV). The unsteady vortices are separated at the leading edge of branch pipe and generated fluctuating pressure wave. After this experience, US-NRC issued that the licensee for new type of reactor should perform a vibration assessment program for an adverse flow effect in the main steam line in accordance with regulatory guideline 1.20 revision 3. In Korea, KHNP CRI implements comprehensive vibration program for steam generator of APR1400 and evaluates acoustic-induced vibration in main steam line using a commercial CFD code, ANSYS CFX 13.0. This paper deals with benchmark analysis to obtain applicability and reliability of commercial code for prediction of acoustic resonance phenomenon in case of single branch pipe test. Based on the benchmark analysis, analysis of main steam line in APR1400 plant is performed. In case of APR1400, five main steam safety valves are installed in the main steam line. Finally, this paper shows a prediction result of acoustic induced vibration characteristic in main steam system of APR1400

  16. An integral effect test on the feedwater line break of APR1400 with the ATLAS facility

    International Nuclear Information System (INIS)

    An integral effect test on the feedwater line break (FLB) was performed with the ATLAS facility for an APR1400 as a typical secondary system transient. The objectives of the present FLB tests are to understand the accident progression of the FLB scenario based on the APR1400 preliminary safety analysis report (PSAR) and to assess the prediction capability of system analysis codes such as the MARS, RELAP5, TRACE and SPACE. The main concern of the present FLB test is the peak RCS pressure and the major parameters affecting the peak RCS pressure are the break size, the break location, potential for reverse flow, initial pressurizer level and the initial SG level. The present test is performed for a break on the pipe connected to the economizer with a typical break size. The initial steady-state conditions and the sequence of event of FLB scenario for the APR1400 were successfully simulated with the ATLAS facility. In the present paper, major thermal-hydraulic phenomena such as the system pressures, the collapsed water levels, and the break flow rate are presented and discussed. It could be concluded that the APR1400 has the capability of coping with the hypothetical FLB scenario with an adequate set of controlling devices and proper setpoints. This integral effect test data could also be used to evaluate the prediction capability of existing safety analysis codes of MARS, RELAP5 and SPACE and to identify any code deficiency for an FLB simulation. (author)

  17. Assessment of Capability of MARS Code for Safety Evaluation of APR+ PAFS

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, Seong Su; Lee, Byung Chul [Seoul National University, Seoul (Korea, Republic of); Park, Ju Yeop; Seul, Kwang Won [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2011-05-15

    In South Korea, advanced power reactor plus (APR+), as a Korean specific reactor, is currently under development for the export strategy. In order to raise competitiveness of the APR+ in the world market, it is necessary to develop the original technology for the improved technology, economics, and safety features. For this purpose, a passive auxiliary feedwater system (PAFS) was adopted as an improved safety design concept of APR+: and then there have been many efforts to develop the PAFS. According to PAFS design concept, PAFS can completely replace the auxiliary feedwater system. When the design basis accident, in which feedwater is not available, occurs, the PAFS can remove the residual heat in the core and then prevent the core damage. In order to develop the safety evaluation system for APR+ PAFS, it is required to assess the calculation capability of MARS code for the passive system with the horizontal type heat exchanger. For this purpose, the main contents of this study are: 1) to simulate the TH phenomena such as natural circulation and horizontal condensation heat transfer in NOKO experiment using MARS-KS, 2) to compare the simulation results between RELAP5 and MARS for PAFS input model

  18. Greta Kaits 9. apr. 1928 - 29. aug. 1946 : [luuletused] / Mats Traat

    Index Scriptorium Estoniae

    Traat, Mats, 1936-

    2008-01-01

    Sisu : Greta Kaits 9. apr. 1928 - 29. aug. 1946 ; Villem Hänilane 1898 - 1952 ; Peeter Pedak 1897 - 1953 ; Max Äidse 1903 - 1959 ; Lavinia Laidam ; Buchard Pruus ; Sergei Krivokopõtov ; Allan Luht 5. VII 1962 - 17. V 2007 ; Karl Saarmets 9. III 1924 - 14. IX 1981 ; Raimo Ritsik

  19. Calculation of fuel and moderator temperature coefficients in APR1400 nuclear reactor by MVP code

    International Nuclear Information System (INIS)

    In this project, these fuel and moderator temperature coefficients were calculated in APR1400 nuclear reactor by MVP code. APR1400 is an advanced water pressurized reactor, that was researched and developed by Korea Experts, its electric power is 1400 MW. The neutronics calculations of full core is very important to analysis and assess a reactor. Results of these calculation is input data for thermal-hydraulics calculations, such as fuel and moderator temperature coefficients. These factors describe the self-safety characteristics of nuclear reactor. After obtaining these reactivity parameters, they were used to re-run the thermal hydraulics calculations in LOCA and RIA accidents. These thermal-hydraulics results were used to analysis effects of reactor physics parameters to thermal hydraulics situation in nuclear reactors. (author)

  20. Analysis of Air Cooling Performance in the Coil Stack Assembly for APR+ CEDMs

    International Nuclear Information System (INIS)

    The control element drive mechanisms (CEDMs) are electromechanical devices for withdrawing, inserting, holding or tripping the control element assemblies (CEAs). The driving power for CEDMs is supplied by the coil stack assembly mounted on the motor housing assembly. The Coil Stack assembly is heated by the motor housing assembly contacted with reactor coolant as well as electric resistance of coil. The CEDMs are cooled by air ventilation. The cooling air around the CEDMs flows into the individual cooling shroud and extracts heat from the coil stacks while it passes between the shroud and coil housing. The cooling performance of the CEDMs is closely related to the geometry configuration of coil stack assembly. The expansion of air passage and additional cooling fins are considered to improve the cooling performance of APR+ CEDMs. In this study the optimal design conditions of APR+ CEDMs are investigated by flow analysis

  1. Available Driving Head Following a Loss-of-Coolant Accident in the APR1400 Design

    International Nuclear Information System (INIS)

    The objective of in-vessel downstream effect (IDE) evaluation is to demonstrate that there is reasonable assurance that sufficient long-term core cooling (LTCC) is achieved with debris and chemical products which are postulated to be transported to the reactor vessel. To maintain LTCC, it should be demonstrated that the available head to drive emergency core cooling (ECC) flow into the core is greater than the head loss across the core due to possible debris buildup. In this paper, the available driving heads following a loss-of-coolant accident (LOCA) in the APR1400 design were presented. The available driving heads of the APR1400 design were calculated in case of HL break, CL break, and CL break after HLSO operation at the recirculation start time (700 seconds after ECC start). The break size spectrum will be analyzed to calculate the available driving head when the loop seal reformation happens after a small break LOCA

  2. External Reactor Vessel Cooling Strategy Application for APR1400 Station Blackout Scenarios

    International Nuclear Information System (INIS)

    In Korea, all NPPs implemented post-Fukushima measures. In U. S., the approach is to expand B5b strategy to build up FLEX strategies utilizing portable equipment. With portable pumps and connections, one can mitigate and respond to wide range of accidents. In this study, we examined the feasibility of cavity flooding using portable pumps for ERVC and its effectiveness in responding to extended SBO scenarios. The external reactor vessel cooling (ERVC) is one of important severe accident management (SAM) strategies adopted for APR1400. ERVC strategy is to remove decay heat from molten corium in lower plenum by submerging the vessel with water. The strategy requires water injection into cavity and APR1400 uses shutdown cooling pumps for this purpose, requiring electricity. Recent Fukushima accident shows the importance of mitigation capability against extended SBO scenarios

  3. Preliminary System Response Analysis of Rod Ejection Accident for APR1000

    International Nuclear Information System (INIS)

    Korea Electric Power Co. (KEPCO) has designed the Advanced Power Reactor 1000 (APR1000) plants implementing the advanced safety features to Optimized Power Reactor 1000 (OPR1000) plants. Prior to developing the detail design, the preliminary design project has been launched since the end of 2009 as a feasibility study. In spite of some difference in safety- related design concepts of two plant types, they could be treated as the same plants considering the main features or systems. In this study, the rod ejection accident (REA) event was analyzed using Korea Non-LOCA Analysis Package (KNAP) hot spot model (HSM) for APR1000 to examine the feasibility of the design concepts and the results were compared with those values calculated by the Safety Analysis Report (SAR) conditions of typical OPR1000 plants. Through the study, it was concluded that the design concepts and the analysis package could be applicable on the view point of REA

  4. External Reactor Vessel Cooling Strategy Application for APR1400 Station Blackout Scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Tran, Quang Diep Khanh; Oh, Seung Jong [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of); Ro, Seo Mi [KHNP Central Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    In Korea, all NPPs implemented post-Fukushima measures. In U. S., the approach is to expand B5b strategy to build up FLEX strategies utilizing portable equipment. With portable pumps and connections, one can mitigate and respond to wide range of accidents. In this study, we examined the feasibility of cavity flooding using portable pumps for ERVC and its effectiveness in responding to extended SBO scenarios. The external reactor vessel cooling (ERVC) is one of important severe accident management (SAM) strategies adopted for APR1400. ERVC strategy is to remove decay heat from molten corium in lower plenum by submerging the vessel with water. The strategy requires water injection into cavity and APR1400 uses shutdown cooling pumps for this purpose, requiring electricity. Recent Fukushima accident shows the importance of mitigation capability against extended SBO scenarios.

  5. CFD Analysis of Flow Characteristics in the PAFS PCCT for APR +

    International Nuclear Information System (INIS)

    The passive auxiliary feedwater system (PAFS) is one of the passive safety features adopted in the APR+. The PAFS has two independent high-pressure closed loops; each loop has a heat exchanger (U-tube bundles) submerged in a PCCT water pool. The PAFS cools the secondary system by heat transfer in a horizontal Utube in the PCCT. The cooling water in the PCCT is maintained at atmospheric pressure, so that boiling heat transfers at the surface of the U-tube and natural convection occurs in the PCCT water pool. The conventional system codes, such as the RELAP5 /Mod3.3 and the MARS codes, are inadequate for flow pattern analysis of this system. The purpose of this study is to analyze the flow characteristics in the PAFS PCCT for APR + utilizing a CFD code, CFX

  6. CFD Analysis of Flow Characteristics in the PAFS PCCT for APR +

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Mun Soo; Chun, Jong [KHNP, Daejeon (Korea, Republic of)

    2010-10-15

    The passive auxiliary feedwater system (PAFS) is one of the passive safety features adopted in the APR+. The PAFS has two independent high-pressure closed loops; each loop has a heat exchanger (U-tube bundles) submerged in a PCCT water pool. The PAFS cools the secondary system by heat transfer in a horizontal Utube in the PCCT. The cooling water in the PCCT is maintained at atmospheric pressure, so that boiling heat transfers at the surface of the U-tube and natural convection occurs in the PCCT water pool. The conventional system codes, such as the RELAP5 /Mod3.3 and the MARS codes, are inadequate for flow pattern analysis of this system. The purpose of this study is to analyze the flow characteristics in the PAFS PCCT for APR + utilizing a CFD code, CFX

  7. The Gravity Makeup on the LORHR Event during Mid-loop Operation for APR1400

    International Nuclear Information System (INIS)

    This paper is to investigate means of the available gravity makeup after the event to prevent or sustain the core uncovery and fuel failure for the typical advanced power reactor nuclear power plants (APR1400). Unlike the OPR1000 (optimized power reactor 1000 nuclear power plants), the refueling water storage tank of APR1400 cannot be used for gravity makeup since it is located on the bottom of the containment with a lower elevation than the reactor vessel. So, the other means of gravity makeup and their effect on the core uncovery are accounted. The use of the water used for the cask loading pit (CLP) during refueling or the safety injection line filling tank (SIFT), which are not designed for gravity makeup during the event, and safety injection tanks (SITs) are considered as the alternative source of makeup feed. The results show that gravity makeup of a SIT provides a sufficient operator action time for the LORHR with the station black out (SBO) during the mid-loop operation for the APR1400. From the LORHR event analysis, the effective means of gravity makeup for APR1400 to cope with this event concurrent loss of all AC power is determined as the gravity feed using SITs. Other means for gravity makeup using CLP or SIFT, which are not designed to mitigate the LORHR event, are evaluated as not effective to the event due to the large flow resistances and the low elevation head to overcome the system pressure increase during the LORHR. The use of one SIT and two SITs for the LORHR provides the core uncovery times as 3 hr 8 min and 4 hr 32 min extending 1 hr 15 min and 2 hr 38 min from the base case, respectively

  8. Acute exercise does not induce an acute phase response (APR) in Standardbred trotters

    OpenAIRE

    Kristensen, Lena; Buhl, Rikke; Nostell, Katarina; Bak, Lars; Petersen, Ellen; Lindholm, Maria; Jacobsen, Stine

    2014-01-01

    The purpose of the study was to investigate whether acute strenuous exercise (1600- to 2500-m race) would elicit an acute phase response (APR) in Standardbred trotters. Blood levels of several inflammatory markers [serum amyloid A (SAA), haptoglobin, fibrinogen, white blood cell count (WBC), and iron], muscle enzymes [creatinine kinase (CK) and aspartate transaminase (AST)], and hemoglobin were assessed in 58 Standardbred trotters before and after racing. Hemoglobin levels increased and iron ...

  9. APR-5000-XLS阵列封装返工系统

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    APR-5000-XLS阵列封装返工系统可处理BGA,CSP,LGA(Land Grid Army),Micro SMD,MLF(Micro Lead Frame),BCC(Bumped Chip Component)多种封装。其可处理的板尺寸达610mm×610mm(24.5”×24.5”),厚度达6.35mm(0.25”)。

  10. Critical heat flux for APR1400 lower head vessel during a severe accident

    International Nuclear Information System (INIS)

    Highlights: ► Studied boiling on downward-facing hemispherical vessel with asymmetric thermal insulator. ► Scaled the APR1400 lower head linearly down by 1/10 including ICI tubes and shear keys. ► Performed thermal analysis using ANSYS V11.0 to determine the internal temperature and heat flux. ► Performed tests to obtain the CHF with saturated demineralized water at atmospheric pressure. ► Measured CHF accounting for 3D random flow effect expected in the APR1400 application. -- Abstract: Corium Ablation Stopper Apparatus (CASA) has a downward-facing hemispherical vessel and geometrically asymmetric thermal insulator of the Advanced Power Reactor 1400 MWe (APR1400) scaled linearly down by 1/10, as well as sixty-one in-core instrumentation (ICI) tubes and four shear keys. The heated vessel plays a pivotal role in CASA depending on the configuration of the oxide pool and metal layer to bring about the focusing effect expected of a molten pool in the lower head during a severe accident. The heated vessel was designed through a trial-and-error method and thermal analysis. Thermal analysis was performed using ANSYS V11.0 to investigate the effect of the internal temperature and heat flux on the integral hemispherical copper vessel. The CASA tests were carried out to obtain the critical heat flux (CHF) with saturated and demineralized water at the atmospheric pressure (0.1 MPa). The CHF in the metal layer through the hemispherical channel was found to be lower than that in the ULPU-2400 configuration V data through the streamlined thermal insulator. The experimental CHF was measured and obtained through the CASA hemispherical heated surface accounting for the three-dimensional random flow effect expected in the APR1400 application

  11. The Gravity Makeup on the LORHR Event during Mid-loop Operation for APR1400

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Cheol Woo; Lee, Yong Hee; Lee, Gyu Cheon; Kim, Shin Whan [KEPCO, Daejeon (Korea, Republic of)

    2015-05-15

    This paper is to investigate means of the available gravity makeup after the event to prevent or sustain the core uncovery and fuel failure for the typical advanced power reactor nuclear power plants (APR1400). Unlike the OPR1000 (optimized power reactor 1000 nuclear power plants), the refueling water storage tank of APR1400 cannot be used for gravity makeup since it is located on the bottom of the containment with a lower elevation than the reactor vessel. So, the other means of gravity makeup and their effect on the core uncovery are accounted. The use of the water used for the cask loading pit (CLP) during refueling or the safety injection line filling tank (SIFT), which are not designed for gravity makeup during the event, and safety injection tanks (SITs) are considered as the alternative source of makeup feed. The results show that gravity makeup of a SIT provides a sufficient operator action time for the LORHR with the station black out (SBO) during the mid-loop operation for the APR1400. From the LORHR event analysis, the effective means of gravity makeup for APR1400 to cope with this event concurrent loss of all AC power is determined as the gravity feed using SITs. Other means for gravity makeup using CLP or SIFT, which are not designed to mitigate the LORHR event, are evaluated as not effective to the event due to the large flow resistances and the low elevation head to overcome the system pressure increase during the LORHR. The use of one SIT and two SITs for the LORHR provides the core uncovery times as 3 hr 8 min and 4 hr 32 min extending 1 hr 15 min and 2 hr 38 min from the base case, respectively.

  12. An Experimental Investigation on APR1400 Penetration Weld Failure by Metallic Melt

    International Nuclear Information System (INIS)

    The penetrations are considered as the most vulnerable parts with respect to the reactor vessel failure when a core melt severe accident occurs and the corium reaches the lower head. Penetration tube failure modes can be divided into two categories; tube ejection out of the vessel lower head and rupture of the penetration tube outside the vessel. Tube ejection begins with degrading the penetration tube weld strength to zero as the weld is exposed to temperatures as high as the weld melting temperature, which is called weld failure, and then overcoming any binding force in the hole in the vessel wall that results from differential thermal expansion of the tube and vessel wall. Tube rupture assumes that the debris bed has melted the instrument tube inside the reactor and melt migrates down into the tube to a location outside the vessel wall where a pressure rupture can occur, thus breaching the pressure boundary. In the present paper, we have a focus on the tube ejection failure mode, specifically on the APR1400 weld failure by direct contact with a metallic melt. The objective is to investigate experimentally the ablation kinetics of an APR1400 penetration weld during the interactions with a metallic melt and to suggest the modification of the existing weld failure model. This paper involves the interaction experiments of two different metallic melts (metallic corium and stainless steel melts) with a weld specimen, and rough estimation of weld failure time. The interaction experiments between the metallic melts and an APR1400 penetration weld were performed to investigate the ablation kinetics of the penetration weld. Metallic corium and stainless steel melts were generated using an induction heating technique and interacted with a penetration weld specimen. The ablation rate of the weld specimen showed a range from 0.109 to 0..244 mm/s and thus the APR1400 penetration weld was estimated to be failed at hundreds of times after the interaction with the melt

  13. Development of the Diverse Means for Reactor Shutdown Function of EU-APR1400

    International Nuclear Information System (INIS)

    This paper provides general descriptions of the EBS focusing on basic design characteristics such as system function, configuration and operation, and presents results from the preliminary verification of system performance. The diverse means for the reactor shutdown function of EU-APR1400 have been developed to comply with the diversity principle of the European design requirements of a new nuclear power plant. The preliminary verification of the EBS performance was done by the ATWS analysis. The analysis results show that the EBS was designed properly. Diversity is the fundamental principle in safety system design of a new nuclear power plant, which uses different mitigation measures to provide diverse ways of responding to a significant event. Regarding the diversity principle, EU-APR1400 (European APR1400) safety system should be in accordance with European design requirements. EBS (Emergency Boration System) is designed to provide the diverse means to shut down the reactor against ATWS (Anticipated Transient Without Scram) and to mitigate the event consequences in the EUAPR1400

  14. Assistant Personal Robot (APR): Conception and Application of a Tele-Operated Assisted Living Robot

    Science.gov (United States)

    Clotet, Eduard; Martínez, Dani; Moreno, Javier; Tresanchez, Marcel; Palacín, Jordi

    2016-01-01

    This paper presents the technical description, mechanical design, electronic components, software implementation and possible applications of a tele-operated mobile robot designed as an assisted living tool. This robotic concept has been named Assistant Personal Robot (or APR for short) and has been designed as a remotely telecontrolled robotic platform built to provide social and assistive services to elderly people and those with impaired mobility. The APR features a fast high-mobility motion system adapted for tele-operation in plain indoor areas, which incorporates a high-priority collision avoidance procedure. This paper presents the mechanical architecture, electrical fundaments and software implementation required in order to develop the main functionalities of an assistive robot. The APR uses a tablet in order to implement the basic peer-to-peer videoconference and tele-operation control combined with a tactile graphic user interface. The paper also presents the development of some applications proposed in the framework of an assisted living robot. PMID:27136552

  15. Single-tube condensation experiment in Passive Auxiliary Feedwater System of APR1400+

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Chang Wook; No, Hee Cheon; Yun, Bong Yo; Jeon, Byong Guk [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

    2012-05-15

    Conventional Korean nuclear power plants, Advanced Power Reactors (APR), are characterized by an active cooling system. However, Active cooling system may not prevent significant damage without any AC power source available for its operation as vividly illustrated through the recent Fukushima incident. In the APR1400+ to be designed, an independent passive cooling system was added in order to overcome the aforementioned shortcomings. In the Passive Auxiliary Feedwater System (PAFS), gravity force and density difference between steam and water are used. The system comprises of 240 condensation tubes to efficiently remove decay heat. Before applying the PAFS to APR1400+, the system's safety and heat removal performance must be verified. The present study experimentally evaluates the heat removal performance of a single tube in the PAFS. The objectives of SCOP (Single-tube Condensation experiment facility of PAFS) are the evaluation of the heat removal performance in the tube of the PAFS and database construction under various tube designs and test conditions. Reaching these objectives, we developed advanced measurement techniques for the amount of moisture, heat flux, and water film thickness.

  16. Assistant Personal Robot (APR: Conception and Application of a Tele-Operated Assisted Living Robot

    Directory of Open Access Journals (Sweden)

    Eduard Clotet

    2016-04-01

    Full Text Available This paper presents the technical description, mechanical design, electronic components, software implementation and possible applications of a tele-operated mobile robot designed as an assisted living tool. This robotic concept has been named Assistant Personal Robot (or APR for short and has been designed as a remotely telecontrolled robotic platform built to provide social and assistive services to elderly people and those with impaired mobility. The APR features a fast high-mobility motion system adapted for tele-operation in plain indoor areas, which incorporates a high-priority collision avoidance procedure. This paper presents the mechanical architecture, electrical fundaments and software implementation required in order to develop the main functionalities of an assistive robot. The APR uses a tablet in order to implement the basic peer-to-peer videoconference and tele-operation control combined with a tactile graphic user interface. The paper also presents the development of some applications proposed in the framework of an assisted living robot.

  17. Assistant Personal Robot (APR): Conception and Application of a Tele-Operated Assisted Living Robot.

    Science.gov (United States)

    Clotet, Eduard; Martínez, Dani; Moreno, Javier; Tresanchez, Marcel; Palacín, Jordi

    2016-01-01

    This paper presents the technical description, mechanical design, electronic components, software implementation and possible applications of a tele-operated mobile robot designed as an assisted living tool. This robotic concept has been named Assistant Personal Robot (or APR for short) and has been designed as a remotely telecontrolled robotic platform built to provide social and assistive services to elderly people and those with impaired mobility. The APR features a fast high-mobility motion system adapted for tele-operation in plain indoor areas, which incorporates a high-priority collision avoidance procedure. This paper presents the mechanical architecture, electrical fundaments and software implementation required in order to develop the main functionalities of an assistive robot. The APR uses a tablet in order to implement the basic peer-to-peer videoconference and tele-operation control combined with a tactile graphic user interface. The paper also presents the development of some applications proposed in the framework of an assisted living robot. PMID:27136552

  18. A Study on the Application of the Display Sharing Function In the APR1400 MCR

    International Nuclear Information System (INIS)

    APR1400 digital Main Control Room (MCR) has been applied to Korean Nuclear Power Plants since Shin-Kori 3 and 4. APR1400 MCR has the advantages to reduce the physical and mental workload and to increase situation awareness through integrated information of Compact Operator Console, Computerized Procedure System (CPS) and Large Display Panel (LDP). But although digital MCR has many advantages, it has a weak point that operators cannot easily oversee other operator's operational behavior like soft control actions. This environment makes it difficult to perform concurrent and independent verification from the viewpoint of human error prevention. This paper presents the application method and design of display sharing function through combination using Large Display Panel (LDP) and Information Flat Panel Display (IFPD) of operator console for more reliable operation than before. Because display sharing function is applied within the Information Processing System (IPS), it is required to maintain the system requirement of the IPS such as the CPU and network load. For quality assurance, display sharing function will be developed in accordance with Human Factors Engineering program (NUREG-0711) and Software Program Manual (SPM). We expect that this technology strengthen the reliable operation of the APR1400

  19. Single-tube condensation experiment in Passive Auxiliary Feedwater System of APR1400+

    International Nuclear Information System (INIS)

    Conventional Korean nuclear power plants, Advanced Power Reactors (APR), are characterized by an active cooling system. However, Active cooling system may not prevent significant damage without any AC power source available for its operation as vividly illustrated through the recent Fukushima incident. In the APR1400+ to be designed, an independent passive cooling system was added in order to overcome the aforementioned shortcomings. In the Passive Auxiliary Feedwater System (PAFS), gravity force and density difference between steam and water are used. The system comprises of 240 condensation tubes to efficiently remove decay heat. Before applying the PAFS to APR1400+, the system's safety and heat removal performance must be verified. The present study experimentally evaluates the heat removal performance of a single tube in the PAFS. The objectives of SCOP (Single-tube Condensation experiment facility of PAFS) are the evaluation of the heat removal performance in the tube of the PAFS and database construction under various tube designs and test conditions. Reaching these objectives, we developed advanced measurement techniques for the amount of moisture, heat flux, and water film thickness.

  20. Consideration of MAAP 5.0.2 ESF Model Characteristics for APR1400 NPP

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Mi Ro; Kim, Hyeong Taek [KHNP-CRI, Daejeon (Korea, Republic of)

    2014-10-15

    After the Fukushima accident, EPRI has developed the MAAP (Modular Accident Analysis Program) version 5 that is expected to make up the limitation of MAAP4, that is to say, the appropriateness of the model for the severe accident phenomena and the applicability to the phenomena in the spent fuel pool and the halfloop operation. Up to now, the newest version of MAAP is 5.0.2 (Build 5020000) that was released officially in December, 2013. In addition to this, it is expected that MAAP 5.0.3 version will be published sooner or later. As a kind of post-Fukushima measures, KHNP is developing the probabilistic safety assessment (PSA) and severe accident management guideline (SAMG) for low power and shutdown (LPSD) mode and MAAP 5.0.2 should be used in these projects as a major analysis program. So, first of all, it is necessary that the parameter file for domestic NPP should be upgraded as current Ver. MAAP4 to Ver. MAAP 5.0.2. KHNP has developed the draft version of parameter file for APR1400 type NPP and is being upgraded continuously. The Engineering Safety Features (ESF) model is one of the unique features of MAAP. In this study, we try to share the general information of the MAAP ESF model and the specific characteristics of APR1400 ESF model based on the newly developed MAAP 5.0.2 parameter file. Currently, while developing the LPSD PSA and LPSD SAMG as a kind of post-Fukushima measures, KHNP have the plan in order to upgrade the old parameter file based on MAAP4 to that based on MAAP5.0.2 for all domestic nuclear power plants. And, as the first effort, we are developing the MAAP 5.0.2 parameter file for APR1400 type NPP. In this study, we tried to develop the more accurate and reasonable ESF model of APR1400. In this process, we can find the distinctions and characteristics of specific ESF model and generalized ESF model of MAAP5.0.2. Also, we can eliminate the confusing concepts existed in the two models. So, it is judged that the newly developed MAAP5

  1. Evaluation of the Main Steam Line Break Accident for the APR+ Standard Design using MARS-KS

    Energy Technology Data Exchange (ETDEWEB)

    Park, M. H.; Kim, Y. S.; Hwang, Min Jeong; Sim, S. K. [Environment Energy Technology, Daejeon (Korea, Republic of); Bang, Young Seok [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2015-05-15

    As a part of licensing evaluation of the APR+ (Advanced Power Reactor +) standard design, Korea Institute of Nuclear Safety(KINS) performed safety evaluation of the APR+ Standard Safety Analysis Report(SSAR). The results of the safety evaluation of the APR+ Main Steam Line Break(MSLB) accident is presented for the most limiting post-trip return-to-power case with the single failure assumption of the Loss Of Offsite Power(LOOP). MARS-KS regulatory safety analysis code has been used to evaluate safety as well as the system behavior during MSLB accident. The MARS-KS analysis results are compared with the results of the MSLB safety analysis presented in the SSAR of the APR+. Independent safety evaluation has been performed using MARS-KS regulatory safety analysis code for the APR+ MSLB accident inside containment for the limiting case of the full power post-trip return-to-power. The results of MARS-KS analysis were compared with the results of the MSLB safety analysis presented in the APR+ SSAR. Due to higher cooldown of the MARS-KS analysis, the MARS-KS analysis results in a higher positive reactivity insertion into the core by the negative moderator and fuel temperature reactivity coefficients than the APR+ SSAR analysis. Both results show no return-to-power during the limiting case of the MSLB inside containment. However, APR+ SSAR moderator temperature reactivity insertion should be evaluated against the MARS-KS moderator density reactivity insertion for is conservatism. This study also clearly shows asymmetric thermal hydraulic behavior during the MSLB accident at intact and affected sides of the downcomer and the core. These asymmetric phenomena should be further investigated for the effects on the system design.

  2. Evaluation of the Main Steam Line Break Accident for the APR+ Standard Design using MARS-KS

    International Nuclear Information System (INIS)

    As a part of licensing evaluation of the APR+ (Advanced Power Reactor +) standard design, Korea Institute of Nuclear Safety(KINS) performed safety evaluation of the APR+ Standard Safety Analysis Report(SSAR). The results of the safety evaluation of the APR+ Main Steam Line Break(MSLB) accident is presented for the most limiting post-trip return-to-power case with the single failure assumption of the Loss Of Offsite Power(LOOP). MARS-KS regulatory safety analysis code has been used to evaluate safety as well as the system behavior during MSLB accident. The MARS-KS analysis results are compared with the results of the MSLB safety analysis presented in the SSAR of the APR+. Independent safety evaluation has been performed using MARS-KS regulatory safety analysis code for the APR+ MSLB accident inside containment for the limiting case of the full power post-trip return-to-power. The results of MARS-KS analysis were compared with the results of the MSLB safety analysis presented in the APR+ SSAR. Due to higher cooldown of the MARS-KS analysis, the MARS-KS analysis results in a higher positive reactivity insertion into the core by the negative moderator and fuel temperature reactivity coefficients than the APR+ SSAR analysis. Both results show no return-to-power during the limiting case of the MSLB inside containment. However, APR+ SSAR moderator temperature reactivity insertion should be evaluated against the MARS-KS moderator density reactivity insertion for is conservatism. This study also clearly shows asymmetric thermal hydraulic behavior during the MSLB accident at intact and affected sides of the downcomer and the core. These asymmetric phenomena should be further investigated for the effects on the system design

  3. Diverse Design Features of EU-APR1400 for Residual Heat Removal Function with Open RCS

    International Nuclear Information System (INIS)

    Diversity is the fundamental principle in safety system design of new nuclear power plants, which uses different mitigation measures to provide diverse ways of responding to a significant event. Regarding the diversity principle, EU-APR1400 (European APR1400) safety system should be in accordance with European design requirements. This paper provides how the core residual heat can be removed with open RCS (Reactor Coolant System) closure head condition using diverse cooling systems assuming a loss of SCS (Shutdown Cooling System). The loss of SCS results from a common cause failure of SCS or a loss of UHS (Ultimate Heat Sink). One of the postulated common cause failures which lead to the loss of SCS can be a manufacturing deficiency of shutdown cooling pumps, component cooling water pumps or essential service water pumps. The limiting event of the loss of SCS is the loss of UHS since the loss of UHS causes losses of safety systems including SCS, CCWS and ESWS. NO operator action inside the MCR (Main Control Room) during the first 30 minutes and outside the MCR during the first 60 minutes can be credited to recover the failed SCS. The diverse means of the EU-APR1400 for the residual heat removal function with RCS open condition have been developed to comply with the diversity principle of the European design requirements of new nuclear power plants. The results of the preliminary assessment show that the diverse design features are expected to satisfy the design criteria. In the future, more detailed design and assessment for this means will be performed considering interface requirements with completing the design of relevant systems and components

  4. Diverse Design Features of EU-APR1400 for Residual Heat Removal Function with Open RCS

    Energy Technology Data Exchange (ETDEWEB)

    Kweon, Hyeong Do; Lee, Keun Sung; Kim, Yong Soo; Kim, Sung Hwan [Korea Hydro and Nuclear Power Co., Ltd., Daejeon (Korea, Republic of)

    2014-05-15

    Diversity is the fundamental principle in safety system design of new nuclear power plants, which uses different mitigation measures to provide diverse ways of responding to a significant event. Regarding the diversity principle, EU-APR1400 (European APR1400) safety system should be in accordance with European design requirements. This paper provides how the core residual heat can be removed with open RCS (Reactor Coolant System) closure head condition using diverse cooling systems assuming a loss of SCS (Shutdown Cooling System). The loss of SCS results from a common cause failure of SCS or a loss of UHS (Ultimate Heat Sink). One of the postulated common cause failures which lead to the loss of SCS can be a manufacturing deficiency of shutdown cooling pumps, component cooling water pumps or essential service water pumps. The limiting event of the loss of SCS is the loss of UHS since the loss of UHS causes losses of safety systems including SCS, CCWS and ESWS. NO operator action inside the MCR (Main Control Room) during the first 30 minutes and outside the MCR during the first 60 minutes can be credited to recover the failed SCS. The diverse means of the EU-APR1400 for the residual heat removal function with RCS open condition have been developed to comply with the diversity principle of the European design requirements of new nuclear power plants. The results of the preliminary assessment show that the diverse design features are expected to satisfy the design criteria. In the future, more detailed design and assessment for this means will be performed considering interface requirements with completing the design of relevant systems and components.

  5. APR1400 l and C architecture with the advanced design feature including high reliability and maintainability

    International Nuclear Information System (INIS)

    The standard design of Advanced Power Reactor 1400 (APR1400) has been developed from 1992 to 2001 and obtained design certification from Korea Institute of Nuclear Safety (KINS) in 2002. The APR1400 standard design is being applied to the construction project of Shin-Kori 3, 4 nuclear power plants, which are scheduled to go into commercial operation in 2013 and 2014 respectively. Full digital I and C systems are adopted in safety and non-safety system of Shin-Kori 3, 4 to enhance safety and cost effectiveness of nuclear power plant. The NSSS/BOP control systems, which have been traditionally independent, are integrated in one DCS platform and one network to reduce the number of cabinets and improve system performance and maintainability. Safety grade I and C systems are designed to meet the regulatory requirements for real-time performance, reliability, single-failure criterion, independence, failure mode effect analysis (FMEA), defense-in-depth and diversity, deterministic control and communication, environmental qualification etc. Defense against common mode failure (CMF) of digital plant protection system is one of the key requirements in designing digital I and C systems. Diverse Protection System (DPS) is designed to be diverse from Plant Protection System (PPS) as a defense against common mode failure of digital plant protection system. Diverse manual ESF actuation is also designed to enforce plant safety against severe situation due to simultaneous all digital system failures of plant protection system. Currently, Shin-Kori 3,4 project is being constructed according to the detailed design based on standard design of APR1400 I and C system. Application of full digital I and C system in Shin-Kori 3,4 is expected to increase safety, reliability and maintainability. (authors)

  6. MARS calculation of PAFS (passive auxiliary feedwater system) heat exchanger in APR+

    International Nuclear Information System (INIS)

    APR+ (Advanced Power Reactor Plus), the next generation nuclear power plant in Korea, adopts PAFS (Passive Auxiliary Feedwater System) as one of the advanced safety feature. To design the condensation heat exchanger in PAFS, the two-phase flow phenomena in horizontal U-tube and PCCT (Passive Condensate Cooling Tank) were investigated by MARS calculation. By benchmarking with NOKO experimental result, MARS code showed a reasonable capability to quantitatively predict the condensation in horizontal tube heat exchanger. And the design of PAFS heat exchanger was proved to sufficiently remove the decay heat by the condensation heat transfer without any active auxiliary feedwater system

  7. MARS calculation of PAFS (passive auxiliary feedwater system) heat exchanger in APR+

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Byoung Uhn; Yun, Byong Jo; Bae, Sung Won; Choi, Ki Yong; Song, Chul Hwa [KAERI, Daejeon (Korea, Republic of); Cheon, Jong [Korea Hydro and Nuclear Power Co., Daejeon (Korea, Republic of)

    2009-07-01

    APR+ (Advanced Power Reactor Plus), the next generation nuclear power plant in Korea, adopts PAFS (Passive Auxiliary Feedwater System) as one of the advanced safety feature. To design the condensation heat exchanger in PAFS, the two-phase flow phenomena in horizontal U-tube and PCCT (Passive Condensate Cooling Tank) were investigated by MARS calculation. By benchmarking with NOKO experimental result, MARS code showed a reasonable capability to quantitatively predict the condensation in horizontal tube heat exchanger. And the design of PAFS heat exchanger was proved to sufficiently remove the decay heat by the condensation heat transfer without any active auxiliary feedwater system.

  8. Thérapies à partir du tissu adipeux : de la chirurgie esthétique et reconstructrice à la thérapie cellulaire. Application à la régénération des tendons chez les chevaux

    OpenAIRE

    Girard, Anne-Claire

    2012-01-01

    Utilisée depuis plus d'un siècle en chirurgie esthétique, la greffe autologue de tissu adipeux, ou lipofilling, est une technique sûre permettant le comblement des tissus mous. Cependant, bien que la technique ait connue de nettes améliorations au cours du temps, les chirurgiens font toujours face à une résorption du greffon qui oblige dans la majorité des cas à planifier plusieurs autres interventions afin que le résultat esthétique soit en adéquation avec les attentes du patient. Le procédé...

  9. Probability of Neutralization Estimation for APR1400 Physical Protection System Design Effectiveness Evaluation

    International Nuclear Information System (INIS)

    It is focusing on development of a new designing process which can be compatible to international standards such as IAEA1 and NRC2 suggest. Evaluation for the design effectiveness was found as one of the areas to improve. If a design doesn't meet a certain level of effectiveness, it should be re-designed accordingly. The effectiveness can be calculated with combination of probability of Interruption and probability of neutralization. System Analysis of Vulnerability to Intrusion (SAVI) has been developed by Sandia National Laboratories for that purpose. With SNL's timely detection methodology, SAVI has been used by U.S. nuclear utilities to meet the NRC requirements for PPS design effectiveness evaluation. For the SAVI calculation, probability of neutralization is a vital input element that must be supplied. This paper describes the elements to consider for neutralization, probability estimation methodology, and the estimation for APR1400 PPS design effectiveness evaluation process. Markov chain and Monte Carlo simulation are often used for simple numerical calculation to estimate PN. The results from both methods are not always identical even for the same situation. PN values for APR1400 evaluation were calculated based on Markov chain method and modified to be applicable for guards/adversaries ratio based analysis

  10. Analysis of a 12-Finger Rod Drop using RETRAN/MASTER Code System for APR1400

    International Nuclear Information System (INIS)

    The Optimized Power Reactor 1000 (OPR1000) has 4-finger and 12-finger Control Element Assemblies (CEAs). When the 12-finger CEA is dropped, Core Protection Calculator System (CPCS) shuts down the reactor to prevent fuel damage that could occur from the sudden reactor power peaking. By contrast, the improved CPCS of Advanced Power Reactor 1400 (APR1400), which has systems similar to those of the OPR1000, decreases reactor power rapidly using its Reactor Power Cutback System (RPCS) to avoid unwanted reactor trips caused by the CPCS during a 12- finger CEA drop event. RETRAN is a best-estimate code for transient analysis of Non-LOCA. The RETRAN control logic, which includes the function of reducing reactor power during a 12-Finger CEA drop, has been developed for the APR1400. A MATRAN program has also been developed. MATRAN is the interface program for realtime processing to connect RETRAN with MASTER code which is a nuclear analysis and design code. MATRAN supplies adequate feedback reactivities from the MASTER code to RETRAN code. The purpose of this study is to analyze the behavior of a nuclear reactor core and its primary system using conventional RETRAN analysis procedure and MATRAN program analysis procedure during a 12- finger CEA drop. In addition, the axial power distribution and Axial Shape Index (ASI) are produced by the MATRAN program and they are confirmed as within operation limits

  11. Advanced Design Features of APR1400 and Realization in Shin Kori Construction Project

    International Nuclear Information System (INIS)

    APR1400 adopted several advanced design features. To ensure their proper operation as a part of ShinKori 3,4 project, both experimental and analytical work are continuing. In this paper, work on the advanced design features related to enhanced safety is examined. APR1400 safety injection system consists of four independent trains which include four safety injection pump and tanks. A passive flow regulating device called fluidic device is installed in the safety injection tanks. Separate effect tests including a full scale fluidic device tests have been conducted. Integral system tests are in progress. Combination of these work with the analytical work using RELAP5/Mod3 would ensure the proper operation of the new safety injection systems. To mitigate severe accidents, hydrogen mitigation system using PARs and igniters is adopted. Also, active injection system and the streamlined insulation design are adopted to enhance the in-vessel retention capability with the external cooling of RPV strategy. Analytic work with supporting experiments is performed. We are certain that these preparatory work would help the successful adaptation of ADF in ShinKori project. (authors)

  12. Probability of Neutralization Estimation for APR1400 Physical Protection System Design Effectiveness Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Myungsu; Lim, Heoksoon; Na, Janghwan; Chi, Moongoo [Korea Hydro and Nuclear Power Co. Ltd. Central Research Institute, Daejeon (Korea, Republic of)

    2015-05-15

    It is focusing on development of a new designing process which can be compatible to international standards such as IAEA1 and NRC2 suggest. Evaluation for the design effectiveness was found as one of the areas to improve. If a design doesn't meet a certain level of effectiveness, it should be re-designed accordingly. The effectiveness can be calculated with combination of probability of Interruption and probability of neutralization. System Analysis of Vulnerability to Intrusion (SAVI) has been developed by Sandia National Laboratories for that purpose. With SNL's timely detection methodology, SAVI has been used by U.S. nuclear utilities to meet the NRC requirements for PPS design effectiveness evaluation. For the SAVI calculation, probability of neutralization is a vital input element that must be supplied. This paper describes the elements to consider for neutralization, probability estimation methodology, and the estimation for APR1400 PPS design effectiveness evaluation process. Markov chain and Monte Carlo simulation are often used for simple numerical calculation to estimate P{sub N}. The results from both methods are not always identical even for the same situation. P{sub N} values for APR1400 evaluation were calculated based on Markov chain method and modified to be applicable for guards/adversaries ratio based analysis.

  13. Experimental study on the operational and the cooling performance of the APR+ passive auxiliary feedwater system

    International Nuclear Information System (INIS)

    The passive auxiliary feedwater system (PAFS) is one of the advanced safety features adopted in the APR+ which is intended to completely replace the conventional active auxiliary feedwater system. The PAFS cools down the steam generator secondary side and eventually removes the decay heat from the reactor core by introducing a natural driving force mechanism; i.e., condensing steam in nearly-horizontal U-tubes submerged inside the passive condensation cooling tank (PCCT). With an aim of validating the cooling and operational performance of the PAFS, the separate effect test, PASCAL (PAFS Condensing Heat Removal Assessment Loop), is being performed to experimentally investigate the condensation heat transfer and natural convection phenomena in the PAFS. A single nearly-horizontal U-tube whose dimension is same as the prototypic U-tube of the APR+ PAFS is simulated in the PASCAL test. By performing the PASCAL test, the major thermal-hydraulic parameters such as local/overall heat transfer coefficients, fluid temperature inside the tube, wall temperature of the tube, and pool temperature distribution in the PCCT were produced not only to evaluate the current condensation heat transfer model but also to present database for the safety analysis related with the PAFS. (authors)

  14. Detection of the apr gene in proteolytic psychrotrophic bacteria isolated from refrigerated raw milk.

    Science.gov (United States)

    Martins, Maurilio L; de Araújo, Elza F; Mantovani, Hilário C; Moraes, Célia A; Vanetti, Maria C D

    2005-07-15

    Bacteria of the genus Pseudomonas have been associated with the spoilage of raw milk and dairy products due to the production of thermostable proteolytic enzymes. The apr gene encodes for alkaline metalloprotease in Pseudomonas and other related bacteria. Its presence in psychrotrophic proteolytic bacteria isolated from raw milk collected from cooling tanks was verified. A polymerase chain reaction (PCR) technique was used with degenerate primers. Total DNA from 112 isolates was pooled in different groups and then used as template for the amplification reactions. Controls consisted of DNA extracted from 26 cultures. An expected DNA fragment of 194 bp was detected in groups that contained bacteria identified as Pseudomonas. The PCR product was observed only when DNA from control cultures of Pseudomonas aeruginosa, Pseudomonas fluorescens, Serratia marcescens and Aeromonas hydrophila were used. A detection limit assay indicated that the apr gene could be directly amplified from pasteurized milk inoculated with 10(8) CFU/ml of P. fluorescens. With this method it was possible to detect proteolytic bacteria at 10(5) CFU/ml in reconstituted skim milk powder if cells were recovered for DNA extraction before amplification. PMID:15992619

  15. Thermal-hydraulic tests and analyses for the APR1400's development and licensing

    International Nuclear Information System (INIS)

    The program on Thermal-Hydraulic Evaluation by Testing and Analysis (THETA) for the development and licensing of the new design features in the APR1400 (Advanced Power Reactor-1400) is briefly introduced with a presentation on the research motivation and typical results of the separate effect tests and analyses of the major design features. The first part deals with multi-dimensional phenomena related to the safety analysis of the APR1400. One research area is related to the multi-dimensional behavior of the Safety Injection (SI) water in a reactor pressure vessel downcomer that uses a direct vessel injection type of SI system. The other area is associated with the condensation of steam jets and the resultant thermal mixing in a water pool; these phenomena are relevant to the depressurization of a Reactor Coolant System (RCS). The second part describes our efforts to develop new components for safety enhancements, such as a fluidic device as a passive SI flow controller and a sparger to depressurize the RCS. This work contributes to an understanding of the new thermal-hydraulic phenomena that are relevant to advanced reactor system designs; it also improves the prediction capabilities of analysis tools for multi-dimensional flow behavior, especially in complicated geometries

  16. Après-Coup in French Psychoanalysis: The Long Afterlife of Nachträglichkeit: The First Hundred Years, 1893 to 1993.

    Science.gov (United States)

    House, Jonathan; Slotnick, Julie

    2015-10-01

    Après-coup finds its origins in Freud's earliest psychoanalytic writings, but it was only half a century ago that French psychoanalysts rediscovered, clarified, and developed the concept and so brought it recognition as an essential Freudian concept. Because the history of après-coup is embedded in the French reading of Freud, this article will give an account of that reading in relation to après-coup. PMID:26485487

  17. Evaluation of Effect of N2 Gas on the Cooling Capability of Passive Auxiliary Feedwater System (PAFS) in APR+

    International Nuclear Information System (INIS)

    In Korea, Advanced Power Reactor Plus (APR+) has being developed by adding passive safety features to Advanced Power Reactor 1400MWe (APR1400). Passive Auxiliary Feedwater System (PAFS) is one of passive system adopted in the APR+ to replace the conventional active auxiliary feedwater system. Because PAFS removes decay heat from the reactor core, it is required to verify the performance of PAFS in postulated accidents cases. In addition, an effect of noncondensable gas on the heat removal capability of PAFS should be evaluated since the non-condensable gas may deteriorate a condensation heat transfer through the condensation heat exchanger in PAFS. In this study, the effect of N2 gas was evaluated using MARS

  18. Thermal-hydraulic evaluation of passive containment cooling system of improved APR+ during LOCAs

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, Byong Guk; NO, Hee Cheon, E-mail: hcno@kaist.ac.kr

    2014-10-15

    Highlights: • Larger air holdup tanks are confirmed to be needed for PCCS through MARS simulation. • Condensation model in MARS gives lower heat transfer than Dehbi's correlation. • Heat transfer resistance of steam–air mixture is dominant for PCCS tubes. • Heat sink structures remove dominant amount of decay heat initially. • Flow instability is eased at higher tube inlet form loss, return level, and angle. - Abstract: Various reactor concepts and technologies have been devised and evaluated to ensure the integrity of the core and the containment under a prolonged station blackout. After the successful validation of the passive auxiliary feedwater system (PAFS) of Advanced Power Reactor Plus (APR+), Korea is considering an improved APR+ with a passive containment cooling system (PCCS). In a previous paper, we suggested a PCCS design based on APR+ and performed a scoping analysis. We performed a MARS simulation for the thermal hydraulic evaluation of the system behavior, including natural circulation through the Passive Condensation Cooling Tank (PCCT) water pool and inside PCCS tubes as well as steam–air mixture condensation inside the containment. Through a simulation using the MARS system code, we investigated the effect of air holdup tanks (AHTs) on reduction of the air fraction in the containment, the effects of several steam–air mixture condensation models, the role of heat structures, and the flow instability inside the PCCS tubes. We found that the presence of AHT reduced the number of required PCCS tubes by more than half and the heat resistance of the steam–air mixture side is dominant in terms of governing the overall performance of PCCS. The embedded MARS condensation model and Uchida's correlation gave lower heat transfer coefficients than Dehbi's correlation, and heat structures removed more decay heat than PCCS tubes. Finally, intense flow instability inside the PCCS tubes was observed and was mitigated by placing

  19. Le Chaebol après la crise financière de 1997

    Directory of Open Access Journals (Sweden)

    Chung-Yeol Park

    2008-11-01

    Full Text Available L’objet de cet article est de présenter les mutations subies par les Chaebols à la suite de la crise financière de 1997. La première section est consacrée à un bref rappel de la formation et du développement des Chaebols, ainsi qu’à une caractérisation des attributs de leur forme organisationnelle. Il s’agit ainsi d’indiquer la « forme  canonique » que revêtait le Chaebol avant la crise, afin de fixer des repères pour mesurer et évaluer l’ampleur et la nature des mutations intervenues après la crise de 1997. La deuxième et la troisième section proposent une analyse de la réforme financière et de la réforme du secteur des entreprises conduites en Corée après 1997 et largement influencées par le FMI. La quatrième section présente une analyse concrète des changements au sein de deux Chaebols majeurs (Hyundai et Samsung depuis la crise financière. A partir de ces études de cas et de données empiriques complémentaires sont mis en évidence tout à la fois les changements et la permanence dans la structure et le comportement des Chaebols, suite aux modifications institutionnelles introduites après la crise financière de 1997.The Chaebol after the 1997. Financial Crisis Changes and Continuity. The paper presents the changes undergone by the Korean Chaebols after the financial crisis of 1997. The first section shortly recalls the history of the birth and development of the Chaebols and presents their specific organizational traits.  The second and third sections are dedicated to the presentation of the financial reforms and of the reforms of the enterprises implemented in Korea after 1997. The fourth section presents two cases studies of the changes introduced after 1997 on two major chaebols : Hyundai Group and Samsung Group. These case studies and other more general empirical data are used to evaluate both the changes and the continuity in Chaebol’s organizational forms and behaviours after the 1997

  20. Analysis of Heat Removal Capability of PAFS (Passive Auxiliary Feedwater System) in APR (Advanced Power Reactor Plus)

    International Nuclear Information System (INIS)

    As passive safety features for nuclear power plants receive increasing attention, South Korea has designed PAFS (Passive Auxiliary Feedwater System) for APR+ (Advanced Power Reactor Plus). Because the PAFS replaces a conventional active auxiliary feedwater system and plays a role in the ultimate heat sink for decay heat, it is necessary to evaluate the heat removal capability of PAFS under postulated accidents conditions. Therefore, the performance analysis is carried out for two accident cases: Loss of Condenser Vacuum (LOCV) and Feedwater Line Break (FLB) accidents. For the analysis, MARS-KS code is used and MARS-KS model is developed by adding PAFS model to the existing APR1400 model

  1. Analysis of Heat Removal Capability of PAFS (Passive Auxiliary Feedwater System) in APR (Advanced Power Reactor Plus)

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Y. J.; Kang, K. H.; Yun, B. J. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2012-03-15

    As passive safety features for nuclear power plants receive increasing attention, South Korea has designed PAFS (Passive Auxiliary Feedwater System) for APR+ (Advanced Power Reactor Plus). Because the PAFS replaces a conventional active auxiliary feedwater system and plays a role in the ultimate heat sink for decay heat, it is necessary to evaluate the heat removal capability of PAFS under postulated accidents conditions. Therefore, the performance analysis is carried out for two accident cases: Loss of Condenser Vacuum (LOCV) and Feedwater Line Break (FLB) accidents. For the analysis, MARS-KS code is used and MARS-KS model is developed by adding PAFS model to the existing APR1400 model.

  2. New tools for NTD vaccines: A case study of quality control assays for product development of the human hookworm vaccine Na-APR-1M74.

    Science.gov (United States)

    Pearson, Mark S; Jariwala, Amar R; Abbenante, Giovanni; Plieskatt, Jordan; Wilson, David; Bottazzi, Maria Elena; Hotez, Peter J; Keegan, Brian; Bethony, Jeffrey M; Loukas, Alex

    2015-01-01

    Na-APR-1(M74) is an aspartic protease that is rendered enzymatically inactive by site-directed mutagenesis and is a candidate antigen component in the Human Hookworm Vaccine. The mutant protease exerts vaccine efficacy by inducing antibodies that neutralize the enzymatic activity of wild type enzyme (Na-APR-1wt) in the gut of the hookworm, thereby depriving the worm of its ability to digest its blood meal. Previously, canines immunized with Na-APR-1(M74) and challenged with Ancylostoma caninum were partially protected against hookworm challenge infection, especially from the loss in hemoglobin observed in control canines and canine immunoglobulin (Ig) G raised against Na-APR-1 was shown to inhibit the enzymatic activity of Na-APR-1 wt in vitro, thereby providing proof of concept of Na-APR-1(M74) as a vaccine antigen. The mutated version, Na-APR-1(M74), was then expressed at the cGMP level using a Nicotiana benthamiana expression system (Fraunhofer, CMB, Delaware, MD), formulated with Alhydrogel®, and used to immunize mice in a dose-ranging study to explore the enzyme-neutralizing capacity of the resulting anti- Na-APR-1(M74) IgG. As little as 0.99 μg of recombinant Na-APR-1(M74) could induce anti Na-APR-1(M74) IgG in mice that were capable of inhibiting Na-APR-1w t-mediated digestion of a peptide substrate by 89%. In the absence of enzymatic activity of Na-APR-1(M74) as a surrogate marker of protein functionality, we developed an assay based on the binding of a quenched fluorescence-labeled inhibitor of aspartic proteases, BODIPY-FL pepstatin A (BDP). Binding of BDP in the active site of Na-APR-1 wt was demonstrated by inhibition of enzymatic activity, and competitive binding with unlabelled pepstatin A. BDP also bound to Na-APR-1(M74) which was assessed by fluorescence polarization, but with an ∼ 50-fold reduction in the dissociation constant. Taken together, these assays comprise a "toolbox" that could be useful for the analyses of Na-APR-1(M74) as it

  3. A MARS and MIDAS Linked Accident Simulation for Large LOCA in APR1400

    International Nuclear Information System (INIS)

    A linked calculation utilizing the design-basis code MARS and the severe accident code MIDAS has been accomplished for a station blackout simulation in APR1400. The MARS code was developed by using the RELAP3/MOD3 and COBRA-TF codes, while the MIDAS code is currently under a development process using the MELCOR code. The objectives of this paper are to explain how to identify the MAR-MIDAS linked calculation outlines and the technical problems, including the MARS data transfer method, the MIDAS input generation works and so on. For the performance verification of the MARS-MIDAS linked calculation, the MARS, MIDAS and their linkage system are run independently for the same initiating event, so that their data can be compared with each other after the selection of proper variables

  4. A MARS and MIDAS Linked Accident Simulation for Large LOCA in APR1400

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Young; Kim, K. R.; Kim, D. H.; Chung, B. D. [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    2006-07-01

    A linked calculation utilizing the design-basis code MARS and the severe accident code MIDAS has been accomplished for a station blackout simulation in APR1400. The MARS code was developed by using the RELAP3/MOD3 and COBRA-TF codes, while the MIDAS code is currently under a development process using the MELCOR code. The objectives of this paper are to explain how to identify the MAR-MIDAS linked calculation outlines and the technical problems, including the MARS data transfer method, the MIDAS input generation works and so on. For the performance verification of the MARS-MIDAS linked calculation, the MARS, MIDAS and their linkage system are run independently for the same initiating event, so that their data can be compared with each other after the selection of proper variables.

  5. Schemes of a MARS and MIDAS linked simulation for SBO in APR1400

    International Nuclear Information System (INIS)

    A linked calculation utilizing the design-basis code MARS and the severe accident code MIDAS has been accomplished for a station blackout simulation in APR1400. The MARS code was developed by using the RELAP3/MOD3 and COBRA-TF codes, while the MIDAS code is currently under a development process using the MELCOR code. In this paper, the MAR-MIDAS linked calculation outlines and the technical problems are presented, including the MARS data transfer method, the MARS and MIDAS node mapping and variable definition principles, the MIDAS input generation works and so on. For the performance verification of the MARS-MIDAS linked calculation, the MARS, MIDAS and their linkage system are run independently for the same initiating event, so that their data can be compared with each other after the selection of proper variables. (author)

  6. Signoles Aude, Le Hamas au pouvoir et après ?, Toulouse, Editions Milan, 2006.

    Directory of Open Access Journals (Sweden)

    Jean-François Legrain

    2007-11-01

    Full Text Available Dans les étroites limites imposées par la collection (absence totale de notes et de bibliographie, 112 p. en format réduit, le petit livre d’Aude Signoles, Le Hamas au pouvoir et après ?, commence à combler un vide de l’édition française. Le seul livre jusque là disponible en français et entièrement consacré à Hamas remonte à 7 années maintenant ; doté de nombreuses erreurs factuelles et faisant comme si Hamas était apparu avec l’autonomie des années 1990, il ignorait tout de son passé d’Ass...

  7. Study on MELCOR Modeling for Emergency External Water Injection Scenario of SBO in APR1400

    International Nuclear Information System (INIS)

    In the present study, a MELCOR model for APR1400 was developed and applied to analyze a SBO scenario selected to confirm the effectiveness of the means. In this analysis, the primary and secondary emergency cooling water injection were considered. Leakage from the Reactor Coolant Pump (RCP) seal and opening of the Atmosphere Dump Valve (ADV) were modeled as well to simulate the external pump injection strategy. In this study, the analysis results showed that the external injection strategy with an ADV manual opening could successfully cool down the reactor for a station blackout accident through its effective implementation. It was found that the RCP seal leakage rate is a sensitive parameter for depressurization of the RCS. In this regard, further study is needed to develop a realistic RCP seal leakage model, referring to detailed technical data

  8. Reliability analysis of protection system of advanced pressurized water reactor - APR 1400

    International Nuclear Information System (INIS)

    Reliability analysis was carried out for the protection system of the Korean Advanced Pressurized Water Reactor - APR 1400. The main focus of this study was the reliability analysis of digital protection system, however, towards giving an integrated statement of complete protection reliability an attempt has been made to include the shutdown devices and other related aspects based on the information available to date. The sensitivity analysis has been carried out for the critical components / functions in the system. Other aspects like importance analysis and human error reliability for the critical human actions form part of this work. The framework provided by this study and the results obtained shows that this analysis has potential to be utilized as part of risk informed approach for future design / regulatory applications

  9. Assessment of fluid flow characteristics for fluidic device in APR 1400

    International Nuclear Information System (INIS)

    New evolutionary light water reactors (LWRs) are being developed all over the world today. Some of those LWRs employ so-called passive safety components that use natural phenomena as the driving force such as expansion of pressurised gas, natural circulation, and so forth. These passive safety components and their systems are applied to improve the safety of nuclear power plants, further achieving not only to simplify the safety system, but also to improve its reliability and to provide a sufficient time margin to enable the operators to cope with accidents. The APR 1400 (Advanced Pressurised Water Reactor), which is a Korean Next Generation Reactor, adopted fluidic device as one of its passive pieces of safety equipment. The fluidic device is installed at the bottom of the inner space of the Safety Injection Tank (SIT) to control the flow rate of emergency cooling water during a large break loss of coolant accident (LBLOCA). During the past two years, a scale model test to obtain the required flow characteristics of the device under the APR 1400 specific conditions has been performed in Korea. The performance verification test was conducted to obtain the optimum characteristics and design data of full fluidic device (FD). In this study, the thermal-hydraulic characteristics for the fluidic device are analysed using SIMPLE algorithm with an aim to develop the assessment and verification guidelines for the APR 1400. To assess the flow characteristics for fluidic device, a three dimensional numerical model is developed and its results are compared with those of experiments. The fluid flow characteristics of the FD, which is passive flow control device in the SIT of APR-1400 are assessed using SIMPLE algorithm using FLUENT code and are compared with the experimental results. In this study, the fluid flow rate and pressure in the FD are predicted on the basis of the boundary condition at the entrance of supply port, control port, and discharge port respectively, so as

  10. Marrakech, un mois plus tard, 10 ans après

    Directory of Open Access Journals (Sweden)

    Bernard Debarbieux

    2011-06-01

    Full Text Available Il y a bientôt un mois, la place Jemma el Fna, dans la médina de Marrakech, et tout Marrakech avec elle, étaient secouées par un attentat terroriste. La ville en parle intensément, dans les rues, dans les cafés, dans les journaux. Il y a 10 ans, cette même place entrait dans le cercle des sites du patrimoine Mondial de l'Humanité. Jemma el Fna retentit cette semaine des festivités organisées pour célébrer cet anniversaire. La fête après le drame ? Comme pour oublier ? Certainement pas. Toujou...

  11. Development and Verification of MAAP5.0.3 Parameter file for APR1400

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Mi Ro; Kim, Hyeong Taek [KHNP-CRI, Daejeon (Korea, Republic of)

    2015-05-15

    After the Fukushima accident, EPRI has continuously upgrade the MAAP5 (Modular Accident Analysis Program version 5) that is expected to expand the limitation of MAAP4. As a result of those efforts, the MAAP5.0.2 (Build 5020000) was released officially in December, 2013. Also, in August, 2014, the newest version of MAAP5, MAAP 5.0.3 (Build 5030000), was officially released. The parameter file development is essential for severe accident analysis using MAAP code for specific plant. In 2014, KHNP developed the first draft version of MAAP 5.0.2 parameter file for APR1400 type NPP and had tested for some basic severe accident sequence. And, until now, KHNP has continuously complemented the first draft version of APR1400 type NPP parameter file for MAAP 5.0.2 and 5.0.3. In this study, we analysis the MCCI phenomena using MAAP 5.0.3 version with the 2''n''d draft version of APR1400 parameter file developed by KHNP. The purpose of this study is to compare the major difference in MAAP 5.0.2 and 5.0.3 MCCI model and to verify the appropriateness of the 2''n''d draft version of parameter file. The MCCI phenomena have been controversial issues in the severe accident progression, so there have been great efforts to solve them until now. As the part of these efforts, EPRI published MAAP 5.0.3 version which is known that the 'Lower head plenum model' and the 'MCCI model' was upgraded. KHNP have the plan in order to upgrade the old parameter file based on MAAP4 to that based on MAAP5.0.2 or higher version for all domestic nuclear power plants. So, we have continuously developed the MAAP 5.0.2 and 5.0.3 parameter file for APR1400 type NPP. In this study, we analyzed the MCCI phenomena using MAAP 5.0.3 and 2''n''d draft version parameter file. And we found some insight as belows; (1) The Melt Eruption Model can greatly affect the MCCI progression only in the case of limestone concrete in the wet cavity

  12. Vertical Seismic Responses of Seismically Isolated APR1400 Structures supported by Laminated Rubber Bearings

    International Nuclear Information System (INIS)

    The low horizontal shear stiffness of the isolator bearing is, typically, accompanied by large lateral displacements in the seismically isolated system. These large lateral displacements might lead to reductions in the vertical stiffness of the elastomeric or lead.rubber bearing (LRB). This paper summarizes the analytical study results performed with APR1400 model isolated with LRBs aimed at investigating the influence of vertical ground motion. Three types of earthquake motions are used as input motion. Floor response spectra are computed at the specific points of the structure to compare the vertical responses of seismically isolated structure to those of fixed base structure. The vertical responses of seismically isolated structure with LRBs might be increased than in the fixed base structure. This fact should be considered in the design stage. The vertical stiffness of the LRB should be reasonably estimated to design a seismically isolated nuclear structure

  13. Development and Verification of MAAP5.0.3 Parameter file for APR1400

    International Nuclear Information System (INIS)

    After the Fukushima accident, EPRI has continuously upgrade the MAAP5 (Modular Accident Analysis Program version 5) that is expected to expand the limitation of MAAP4. As a result of those efforts, the MAAP5.0.2 (Build 5020000) was released officially in December, 2013. Also, in August, 2014, the newest version of MAAP5, MAAP 5.0.3 (Build 5030000), was officially released. The parameter file development is essential for severe accident analysis using MAAP code for specific plant. In 2014, KHNP developed the first draft version of MAAP 5.0.2 parameter file for APR1400 type NPP and had tested for some basic severe accident sequence. And, until now, KHNP has continuously complemented the first draft version of APR1400 type NPP parameter file for MAAP 5.0.2 and 5.0.3. In this study, we analysis the MCCI phenomena using MAAP 5.0.3 version with the 2''n''d draft version of APR1400 parameter file developed by KHNP. The purpose of this study is to compare the major difference in MAAP 5.0.2 and 5.0.3 MCCI model and to verify the appropriateness of the 2''n''d draft version of parameter file. The MCCI phenomena have been controversial issues in the severe accident progression, so there have been great efforts to solve them until now. As the part of these efforts, EPRI published MAAP 5.0.3 version which is known that the 'Lower head plenum model' and the 'MCCI model' was upgraded. KHNP have the plan in order to upgrade the old parameter file based on MAAP4 to that based on MAAP5.0.2 or higher version for all domestic nuclear power plants. So, we have continuously developed the MAAP 5.0.2 and 5.0.3 parameter file for APR1400 type NPP. In this study, we analyzed the MCCI phenomena using MAAP 5.0.3 and 2''n''d draft version parameter file. And we found some insight as belows; (1) The Melt Eruption Model can greatly affect the MCCI progression only in the case of limestone concrete in the wet cavity

  14. Analysis Of Control Rod Ejection Of APR1400 By RELAP5

    International Nuclear Information System (INIS)

    This paper presents the analysis of Reactivity Induced Accident caused by ejection of a Control Element Assembly (CEA) from APR 1400 reactor vessel within 0.05 second. The initial condition were assumed as following: power level at 102%, delayed neutron fraction β = 412 pcm and CEA worth = 110 pcm. The analysis was simulated by RELAP5 code through two step: calculation of steady state and calculation of transient with initial condition mentioned as above. Some output results were presented with explanation: sequence of events corresponding to the time of the accident, the system behavior as power, reactivity feedback from fuel temperature changes (Doppler) as well as temperature, pressure, DNBR within 6 second of the accident. (author)

  15. Analysis Of Feedwater Line Break Of APR1400 By MARS Code

    International Nuclear Information System (INIS)

    This paper will deal with analysis of Feed water Line Break problem (FWLB) of the APR 1400 NPP with initial conditions: operation at 100% of power, double-ended break area of 0.058 m2 and the break location of the feedwater line between the check valve and the steam generator. The analysis was simulated by MARS code through two step: calculation for steady state and calculation for transient state with initial condition mentioned. Some output result were presented with explanation: sequence of events corresponding to the time of the accident, the system behavior as temperature, pressure, steam generator water levels as well as DNBR, etc. before and after the accident. (author)

  16. Preliminary Analysis of Ex-Vessel Steam Explosion using TEXAS-V code for APR1400

    International Nuclear Information System (INIS)

    The purpose of this study is to explore input development and the audit calculation using TEXAS-V code for ex-vessel steam explosion for a flooded reactor cavity of APR1400. TEXAS computational models are one of the simplified tools for simulations of fuel-coolant interaction during mixing, triggering and explosion phase. The models of TEXAS code were validated by performing the fundamental experimental investigation in the KROTOS facility at JRC, Ispra. The experiments such as KROTOS and FARO experiment are aimed at providing benchmark data to examine the effect of fuel-coolant initial conditions and mixing on explosion energetics with alumina and prototypical core material. TEXAS-V code used in this study was to analyze and predict the ex-vessel steam explosion for a reactor scale. The input deck to simulate the flooded reactor cavity of APR1400 is developed and base case calculation is performed. This study will provide a base for further study. The code will be of use for the evaluation and sensitivity study of ex-vessel steam explosion for ERVC strategy in the future studies. Analysis result of this study is similar to the result of other study. Through this study, it is found that TEXAS-V could be the used as a tool for predicting the steam explosion load on a reactor scale, as fast running computer code. In addition, TEXAS-V code could be to evaluate the impact of various uncertainties, which are not clearly understood yet, to provide a conservative envelope for the steam explosion

  17. Separate and integral effect tests for validation of cooling and operational performance of the APR+ passive auxiliary feedwater system

    International Nuclear Information System (INIS)

    The passive auxiliary feedwater system (PAFS) is one of the advanced safety features adopted in the APR+, which is intended to completely replace the conventional active auxiliary feedwater system. With an aim of validating the cooling and operational performance of PAFS, an experimental program is in progress at KAERI, which is composed of two kinds of tests; the separate effect test and the integral effect test. The separate effect test, PASCAL (PAFS Condensing Heat Removal Assessment Loop), is being performed to experimentally investigate the condensation heat transfer and natural convection phenomena in PAFS. A single, nearly-horizontal U-tube, whose dimensions are the same as the prototypic U-tube of the APR+ PAFS, is simulated in the PASCAL test. The PASCAL experimental result showed that the present design of PAFS satisfied the heat removal requirement for cooling down the reactor core during the anticipated accident transients. The integral effect test is in progress to confirm the operational performance of PAFS, coupled with the reactor coolant systems using the ATLAS facility. As the first integral effect test, an FLB (feedwater line break) accident was simulated for the APR+. From the integral effect test result, it could be concluded that the APR+ has the capability of coping with the hypothetical FLB accident by adopting PAFS and proper set-points of its operation.

  18. Validating the AP[R] German Language Exam through a Curricular Survey of Third-Year College Language Courses

    Science.gov (United States)

    Bischof, Deborah Lokai

    2005-01-01

    Curriculum surveys are used periodically to validate the use of Advanced Place Program[R] (AP[R]) Exams as assessments of skills required for advanced college-level study. In the case of AP German Language, the target level is third-year college language study. This article presents results from a 2003 curriculum survey completed by third-year…

  19. Development of the Phenomena Identification Ranking Table (PIRT) for the Passive Auxiliary Feedwater System (PAFS) of the APR+

    International Nuclear Information System (INIS)

    The APR+ (Advanced Power Reactor plus) is a Gen- III+ pressurized water reactor (PWR) of which the standard design is currently being developed in Korea. This reactor adopts new design features which are believed to contribute not only to enhancement in nuclear safety but also to improvement in economic competitiveness. While the conventional nuclear power plants have utilized the active cooling systems, the APR+ adopts two types of passive safety features; an advanced fluidic device (FD+) and a passive auxiliary feedwater system (PAFS). The PAFS is one of the passive cooling systems of the APR+ which can replace an active system for auxiliary feedwater injection to a steam generator. A schematic diagram of the PAFS is shown in Fig. 1. It cools down the secondary system by heat transfer at horizontal heat exchangers in a PCCT (Passive Condensation Cooling Tank). High pressure steam flow from the steam generator is condensed in the horizontal heat exchanger, and the water in the PCCT pool is evaporated by a boiling heat transfer at the outside wall of the heat exchanger. With an aim of validating the cooling and operational performance of the PAFS, a separate effect test, PASCAL (PAFS Condensing heat removal Assessment Loop) is being performed at KAERI (Korea Atomic Energy Research Institute). In this study, Phenomena Identification and Ranking Table (PIRT) has been developed for identifying the major parameters affecting the thermal-hydraulic phenomena which originate from the adoption of the PAFS in the APR+. The PIRT process can be widely used to improve a safety analysis code for a new application and to establish experimental programs and to support the resolution of the licensing issues. The PIRT process used in this study follows the methodology previously applied in the APR1400 (Advanced Power Reactor 1400 MWe) PIRTs for large break loss of coolant accident (LBLOCA) and direct vessel injection (DVI) line break events

  20. Development of the Phenomena Identification Ranking Table (PIRT) for the Passive Auxiliary Feedwater System (PAFS) of the APR+

    Energy Technology Data Exchange (ETDEWEB)

    Song, Chul Hwa; Chung, Bub Dong; Kang, Kyoung Ho; Kang, Han Ok [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Yun, Byong Jo [Pusan National University, Busan (Korea, Republic of); Bang, Young Suk [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of); Seong, Ho Je [KEPCO E and C, Yongin (Korea, Republic of); Hong, Soon Joon [FNC Technology Co. Ltd., Seoul (Korea, Republic of); Sim, Suk Ku [EN2t Inc., Daejeon (Korea, Republic of)

    2012-05-15

    The APR+ (Advanced Power Reactor plus) is a Gen- III+ pressurized water reactor (PWR) of which the standard design is currently being developed in Korea. This reactor adopts new design features which are believed to contribute not only to enhancement in nuclear safety but also to improvement in economic competitiveness. While the conventional nuclear power plants have utilized the active cooling systems, the APR+ adopts two types of passive safety features; an advanced fluidic device (FD+) and a passive auxiliary feedwater system (PAFS). The PAFS is one of the passive cooling systems of the APR+ which can replace an active system for auxiliary feedwater injection to a steam generator. A schematic diagram of the PAFS is shown in Fig. 1. It cools down the secondary system by heat transfer at horizontal heat exchangers in a PCCT (Passive Condensation Cooling Tank). High pressure steam flow from the steam generator is condensed in the horizontal heat exchanger, and the water in the PCCT pool is evaporated by a boiling heat transfer at the outside wall of the heat exchanger. With an aim of validating the cooling and operational performance of the PAFS, a separate effect test, PASCAL (PAFS Condensing heat removal Assessment Loop) is being performed at KAERI (Korea Atomic Energy Research Institute). In this study, Phenomena Identification and Ranking Table (PIRT) has been developed for identifying the major parameters affecting the thermal-hydraulic phenomena which originate from the adoption of the PAFS in the APR+. The PIRT process can be widely used to improve a safety analysis code for a new application and to establish experimental programs and to support the resolution of the licensing issues. The PIRT process used in this study follows the methodology previously applied in the APR1400 (Advanced Power Reactor 1400 MWe) PIRTs for large break loss of coolant accident (LBLOCA) and direct vessel injection (DVI) line break events

  1. Analysis of steam condensation in APR1400 IRWST for loss of coolant accident

    International Nuclear Information System (INIS)

    The In-Containment Refueling Water Storage Tank (IRWST) of APR1400 is installed at the bottom of containment building to promote the plant safety functions during an accident. This design feature brings about uncertainty factors which may necessitate conventional prediction of temperature and pressure of containment building improved or revised when an accident occurs. The hot steam which is released from RCS break enters the IRWST through four Pressure Relief Dampers (PRDs). It is expected to be condensed with water stored in IRWST, in which water is colder than incoming steam. The purpose of this study is to investigate the influence of IRWST and pressure relief damper on back pressure and temperature in APR1400 containment codes such as CONTEMPT-LT and GOTHIC. The comparison of codes showed that GOTHIC code be more appropriate for the prediction of containment pressure and temperature under the condition of steam condensation occurring in confined water pool. Especially, the GOTHIC has superior capability to treat multi-compartmentalized geometry This study developed one-compartment (single) model, two-compartment (separated) model, and three-dimension (3-D) model, respectively. Two compartment model separates the IRWST from the other containment compartments. In 3-D model, only the IRWST is nodalized with Cartesian modeling. The single model is developed for comparison with two-compartment model which can analyze PRD's influence. The separated model for predicting PRD's influence divides the space between containment and IRWST. 3-D model for IRWST was generated because it is not symmetric considering location of sparger, pump, and suction sump. Therefore, IRWST is simulated with not only detailed three-dimensional behavior but also independent flow paths for four PRDs. Many experimental studies for the direct-contact heat transfer in stratified steam water flows, cocurrent or countercurrent, have been performed (Segev et al., 1981; Lim et al., 1981; Kim and

  2. Apreçamento de opções de IDI usando o modelo CIR

    Directory of Open Access Journals (Sweden)

    José Santiago Fajardo Barbachan

    2003-06-01

    Full Text Available A opção de IDI da BM&F possui características peculiares que torna o seu apreçamento diferente das opções de taxa de juros mais comuns, como as de títulos de renda fixa. Este artigo desenvolve uma fórmula para apreçamento dessas opções de IDI, utilizando a precificação livre de arbitragem. O modelo utilizado considera apenas um fator estocástico: a taxa de juros livre de risco de curto prazo. A equação diferencial usada para modelar o comportamento da taxa de juros é a do modelo CIR (COX INGERSOLL & ROSS, 1985, que possui reversão à média e não permite a existência de taxas de juros nominais negativas. Também é feita uma estimação dos parâmetros do modelo proposto baseando-se em dados históricos, para então comparar o preço teórico da opção baseado nestes parâmetros com os preços de mercado e com o preço teórico considerando a modelagem de Vasicek (1977.The IDI option from the BM&F (Commodities and Futures Exchange has unusual characteristics, that make its pricing different from common interest rate options. This paper develops a closed form formula for the pricing of these IDI options, using an arbitrage-free pricing approach. The model used considers only one stochastic factor: the short-term risk-free interest rate. The differential equation used to model the behavior of the interest rate comes from the CIR (COX INGERSOLL & ROSS, 1985 model, which has mean reversion property and does not allow negative nominal interest rates. It is also done a parameter estimation of the proposed model based on historic data, and then compares the theoretical price of the option based on these parameters with the market price and with the theoretical price considering the Vasicek (1977 model.

  3. Numerical Analysis of Molten Corium Dispersion during Hypothetical High-Pressure Accidents in APR1400 Nuclear Power Plant

    International Nuclear Information System (INIS)

    During a hypothetical high-pressure accident in a nuclear power plant (NPP), molten corium can be ejected through a breach of a reactor pressure vessel (RPV) and dispersed by the following jet of a high pressure steam in the RPV. The dispersed corium is fragmented into smaller droplets in a reactor cavity of the NPP by the steam jet with very high velocity and is released into the upper compartment of the NPP by an overpressure in the cavity. The heat-carrying fragments of the corium transfer the thermal energy to the ambient air in the containment and react chemically with steam and generate hydrogen which may be burnt in the containment. The thermal loads from the ejected molten corium on the containment which is called direct containment heating (DCH) can threaten the integrity of the containment. New generation NPPs such as APR1400 and EPR have been designed in consideration of reducing the possibility of the containment failure from the DCH. In order for that, APR1400 has a convolute-type corium chamber connected to the reactor cavity. In the case of EPR, severe-accident dedicated depressurization valves are installed to preclude a high pressure melt ejection (HPME). DCH in a NPP containment is related to many physical phenomena such as multi-phase hydrodynamics, thermodynamics and chemical reaction. In the evaluation of the DCH load, the melt dispersion rates depending on the RPV pressure are the most important parameter. Mostly, DCH was evaluated by using lumped-analysis codes with some correlations obtained from experiments for the dispersion rates. The corium dispersion rates for many types of the NPP containments had been obtained by experiments in 90s. And some correlations from the experimental data were developed. As mentioned above, APR1400 has a corium chamber to reduce the corium dispersion rate. But there is no experimental data for the dispersion rate specific to the APR1400 cavity geometry. So its performance for capturing of the dispersed corium

  4. Numerical Analysis of Overpressure Transient during Cold Shutdown Operation for APR1400 Nuclear Power Plant

    International Nuclear Information System (INIS)

    ASME code describes specified requirements as allowable pressure for materials of RCPB for low temperature condition. RCPB should be protected during the condition as well because, if it fails, radioactive material can be released. ASME section III appendix G stipulates that maximum allowable pressure of reactor coolant system is 20% of hydrostatic test pressure which means the maximum allowable pressure below lowest service temperature. Generally we determine most severe mass-addition or energy-addition transients arisen by operator errors, malfunction of components or other causes for initiating events of LTOP (low temperature overpressure protection) analysis. According to safety analysis report for APR1400, most severe transient for mass addition begins from startup of one charging pump and four high pressure safety injection (HPSI) pumps at the same time and, on the other hand, most severe transient for energy addition begins from startup of one reactor coolant pump and, as a results of it, heat transfer from secondary side of SG filled with higher temperature water to primary side of SG. If RCS pressure increases and reaches a set pressure of LTOP relief valves, installed on suction pipe of shutdown cooling system (SCS), the valves perform the function of RCPB protection during cold shutdown status. PR1400 for overpressure transient under cold shutdown status. From the results of analysis of mass addition and energy addition, maximum RCS pressure is maintained lower than maximum allowable pressure for LTOP required in ASME code

  5. Numerical study on thermal stratification phenomenon in SCS branch pipe for APR1400

    International Nuclear Information System (INIS)

    The thermal stratification in the unisolable branch pipe for the Shutdown Cooling System (SCS) suction line for APR1400 has been studied. The vertical-horizontal branch pipe with an isolation valve at the end, and under Reactor System (RCS) operating condition is susceptible to the thermal stratification due to the stagnation flow around the isolation valve. The formation of the thermal stratification at the horizontal part of the branch line should be evaluated to determine the design consideration of thermal fatigue. Three dimensional transient analysis for the thermal stratification in a branch pipe is performed using the computational fluid dynamics code, FLUENT, to evaluate the velocity and temperature distribution. Parametric studies have been carried out to investigate the effect of the design and operating conditions. Parameters like the hot leg flow velocity, the outleakage through the isolation valve and the thermal insulation on piping wall are taken account. The analyses show that the temperature difference caused by the thermal stratification at the horizontal part of the unisolable branch pipe is not remarkable under normal operating conditions since the turbulent penetration length is developed deeply in the branch pipe due to the high velocity flow in the RCS hot leg. (author)

  6. A study on the mitigating capability of an auxiliary feedwater system during SBO for APR1400

    International Nuclear Information System (INIS)

    The objective of this paper is to establish an auxiliary feedwater (AFW) operational technical bases for the Korean Next Generation Reactor (APR1400) by modeling the plant, and by analyzing station blackout (SBO) using the MELCOR code. For the integrity of the reactor vessel and containment safety against severe accidents, it is essential to understand the severe accident sequences and to assess accident progression accurately using computer codes. Furthermore, it is important to attain the capability to analyze the advanced nuclear reactor design for the severe accident prevention and mitigation. Accident analyses are also undertaken to find out how effective AFW is mitigating in severe accident progresses. A nominal base case for SBO without AFW, time interval between feedwater stop and reactor vessel failure is 12,740 seconds. When AFW operates to mitigate the SBO accident progression 2, 4 and 8 hours after SBO starts, the reactor vessel failure is delayed for 20,415 seconds, 22,633 seconds and 26,508 seconds, respectively thus the operator has more time available for AC recovery and accident mitigation to prevent reactor vessel failure. (author)

  7. Numerical Analysis of Overpressure Transient during Cold Shutdown Operation for APR1400 Nuclear Power Plant

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Byung Soo; Kim, Yun Il; Jung, Ae Ju; Min, Bok Ki [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2015-05-15

    ASME code describes specified requirements as allowable pressure for materials of RCPB for low temperature condition. RCPB should be protected during the condition as well because, if it fails, radioactive material can be released. ASME section III appendix G stipulates that maximum allowable pressure of reactor coolant system is 20% of hydrostatic test pressure which means the maximum allowable pressure below lowest service temperature. Generally we determine most severe mass-addition or energy-addition transients arisen by operator errors, malfunction of components or other causes for initiating events of LTOP (low temperature overpressure protection) analysis. According to safety analysis report for APR1400, most severe transient for mass addition begins from startup of one charging pump and four high pressure safety injection (HPSI) pumps at the same time and, on the other hand, most severe transient for energy addition begins from startup of one reactor coolant pump and, as a results of it, heat transfer from secondary side of SG filled with higher temperature water to primary side of SG. If RCS pressure increases and reaches a set pressure of LTOP relief valves, installed on suction pipe of shutdown cooling system (SCS), the valves perform the function of RCPB protection during cold shutdown status. PR1400 for overpressure transient under cold shutdown status. From the results of analysis of mass addition and energy addition, maximum RCS pressure is maintained lower than maximum allowable pressure for LTOP required in ASME code.

  8. General relativistic magnetohydrodynamic simulations of binary neutron star mergers with the APR4 equation of state

    Science.gov (United States)

    Endrizzi, A.; Ciolfi, R.; Giacomazzo, B.; Kastaun, W.; Kawamura, T.

    2016-08-01

    We present new results of fully general relativistic magnetohydrodynamic simulations of binary neutron star (BNS) mergers performed with the Whisky code. All the models use a piecewise polytropic approximation of the APR4 equation of state for cold matter, together with a ‘hybrid’ part to incorporate thermal effects during the evolution. We consider both equal and unequal-mass models, with total masses such that either a supramassive NS or a black hole is formed after merger. Each model is evolved with and without a magnetic field initially confined to the stellar interior. We present the different gravitational wave (GW) signals as well as a detailed description of the matter dynamics (magnetic field evolution, ejected mass, post-merger remnant/disk properties). Our simulations provide new insights into BNS mergers, the associated GW emission and the possible connection with the engine of short gamma-ray bursts (both in the ‘standard’ and in the ‘time-reversal’ scenarios) and other electromagnetic counterparts.

  9. General Relativistic Magnetohydrodynamic Simulations of Binary Neutron Star Mergers with the APR4 Equation of State

    CERN Document Server

    Endrizzi, Andrea; Giacomazzo, Bruno; Kastaun, Wolfgang; Kawamura, Takumu

    2016-01-01

    We present new results of fully general relativistic magnetohydrodynamic (GRMHD) simulations of binary neutron star (BNS) mergers performed with the Whisky code. All the models use a piecewise polytropic approximation of the APR4 equation of state (EOS) for cold matter, together with a "hybrid" part to incorporate thermal effects during the evolution. We consider both equal and unequal-mass models, with total masses such that either a supramassive NS or a black hole (BH) is formed after merger. Each model is evolved with and without a magnetic field initially confined to the stellar interior. We present the different gravitational wave (GW) signals as well as a detailed description of the matter dynamics (magnetic field evolution, ejected mass, post-merger remnant/disk properties). Our simulations provide new insights into BNS mergers, the associated GW emission and the possible connection with the engine of short gamma-ray bursts (both in the "standard" and in the "time-reversal" scenarios) and other electro...

  10. Thermal-hydraulic evaluation of passive containment cooling system of improved APR+ during LOCAs

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, Byong Guk; No, Hee Cheon [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

    2014-05-15

    In performance of Passive Containment Cooling System (PCCS), sound operation of PCCS heat exchanger (HX) tubes is vital. To clarify their heat transfer function, various experiments are in progress, involving our group. Furthermore, in case of externally condensed HXs, careful evaluation of flow instability inside HX tubes are of prime importance. In PANDA integral tests targeting HXs of KERENA, a huge oscillation of flow inside tubes is observed. Flow instability is attributed to various reasons and classified into two types: static instability (ex. Ledinegg instability) and dynamic instability (ex. density wave oscillation). The former one is related to multiple stable flow rates at a given pressure drop under equilibrium condition while the latter one involves propagation time and feedback phenomena in transient condition. PCCS tubes correspond to the second type, dynamic instability. The detailed explanations are well documented. Our group suggested a PCCS design featuring an air holdup tank (AHT) for removing air near heat exchangers. Based on the design, the thermal hydraulic characteristics of PCCS are explored in this paper. Thermal hydraulic assessment of proposed PCCS is performed using a system code, MARS. Based on APR+, the required number of PCCS HX tubes are calculated with respect to AHT volume. We confirmed that larger AHT is preferred. Flow instability inside PCCS HX tubes are observed. Through sensitivity study, larger inlet orifice plate, return nozzle height, and tube angle are found to be most effective in stabilizing the flow.

  11. Numerical study of fluidic device in APR1400 using free surface model

    International Nuclear Information System (INIS)

    A fluidic device (FD) has been adopted in the safety injection tanks (SITs) of APR1400. A flow control mechanism of the FD was used to vary the flow regime in the vortex chamber corresponding to the SITs water level. The flow regime in the vortex chamber has a different pressure loss from low to high in accordance with the SITs water level. Nitrogen at the top of the SIT could be released owing to inertia of discharge flow when changing from a high flow rate to a low flow rate. This phenomenon is important to design improvement perspective because it can affect the performance of the FD. This paper shows a result of a preliminary numerical study to obtain the transient data related to air release in the flow turn down period using a two fluid free surface model provided from ANSYS CFX 13.0. In conclusion, there is no significant effect on the performance of the FD, though a small quantity of air is released during the flow turn down period

  12. Ārsta un farmaceita sadarbība pacientu aprūpē

    OpenAIRE

    Tione, Zane

    2016-01-01

    Sakārtota un pieejama veselības aprūpes sistēma valstī, var ievērojami uzlabot dzīves kvalitāti un nodrošināt valsts izaugsmi un konkurētspēju. Tomēr, kā zināms, svarīgs nosacījums šajā procesā ir arī pašu sistēmas dalībnieku iniciatīvai, viņu izrādītā vēlme uz sadarbību, vienotu mērķu sasniegšanai. Aktuāli ir noskaidrot kāda ir šī brīža situācija valstī, vai ārstiem un farmaceitiem ir vēlme šo komunikāciju uzlabot. Bakalaura darba mērķis ir noskaidrot vai pastāv ārstu un farmaceitu sadarbīb...

  13. Development of combined modularization technology for APR+ (Advanced Power Reactor) in Korea

    International Nuclear Information System (INIS)

    Full text: KHNP is currently operating 20 nuclear power plants and constructing 8 units in Korea. With the accumulated experience of operation and construction of NPPs over the past 50 years, KHNP tries to develop the original nuclear power reactor (APR+). The R and D project for 'combined modularization', which is a part of APR+ common core technology development, is being carried out and will be implemented by July 2010. This R and D project was initiated from the feasibility study on the modularization of structure and system facility for NPPs (2002). On the basis of the feasibility study result, The SC (Steel plate Concrete) structure technology development had been performed from 2005 to 2008, and the SC structure technology is under audit by the regulatory institution prior to the application for nuclear construction project. The research of combined modularization is an extension from the SC structure technology development. The research is divided into three phases. During first phase, by July 2010, the applicability of SC structure enlargement will be reviewed and conceptual design of combined/equipment modularization will be performed. In second phase, the basic design and construction feasibility evaluation of the screened combined/equipment modularization will be completed within July 2013. Afterward, in the final phase, optimized modularization technique will be realized through technical supplementation by Dec. 2015. Two main objectives will be achieved in the first phase study. The first one is to obtain design reliabilities for the SC structure by evaluating its applicability in auxiliary/compound building. The other one is to establish modularization requirements for design, procurement, manufacture and installation. To ensure these objectives, the flow sheet of technology development is greatly divided into 5 steps as follows. First step is to establish the screen criteria for adopting modularization. It's possible to catch the attitude of impact

  14. Sub compartment pressurization analysis for auxiliary building of APR1400DC

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Moon Oh; Lee, Hee Do [Atomic Creative Technology, Daejeon (Korea, Republic of)

    2012-10-15

    Generally, the sub compartment of PWR means a fully or partially enclosed volume that could house high-energy piping systems or restrict the flow of fluid in the event of a postulated pipe rupture. To meet the requirements of General Design Criteria (GDC) 4 and 50, Standard Review Plan (SRP) 6.2.1.2 states that the sub compartments shall be designed with sufficient margin to prevent the fracture of structure due to pressure differential across the walls of the sub- compartment and specifies the criteria related to the design and functional sub compartment nodalization schemes, vent flow path and vent flow behavior. Therefore the sub compartments structures within the containment and auxiliary building are designed to withstand the transient differential pressures loads, jet impingement forces, and pipe whip forces occurring due to a postulated pipe break. In this paper, the analyses of pressure transients after a postulated pipe rupture in sub compartments of APR1400DC auxiliary building is performed and the calculated peak differential pressures during the piping break transients for each sub compartment are less than structural design differential pressures.

  15. Evaluation on thermal-hydraulic characteristics for passive safety device of APR1400

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Seong Yeon; Lee, S. H.; Son, M. K. [Korea Association for Nuclear Technology, Taejon (Korea, Republic of); Jee, M. S.; Chung, M. H. [Chungnam National Univ., Taejon (Korea, Republic of)

    2001-07-15

    To establish evaluation and verification guideline for the APR1400, thermal-hydraulic characteristics for fuel rod bundle, reactor vessel and fluidic device is analyzed using FLUENT. Scope and major results of research are as follows : Thermal-hydraulic characteristics for nuclear fuel rod bundle: design data for nuclear fuel rod bundle and structure are surveyed, and 3 x 3 sub-channel model is adopted to investigate the fluid flow and heat transfer characteristics in fuel rod bundle. Computational results are compared with the heat transfer data measured by naphthalene sublimation method, and numerical analysis and evaluation are performed at various design conditions and flow conditions. Thermal-hydraulic characteristics for reactor vessel: reactor vessel design data are surveyed to develop numerical model. Porous media model is applied for fuel rod bundle, and full-scale, three dimensional simulation is performed at actual operating conditions. Distributions of velocity, pressure and temperature are discussed. Flow characteristics for fluidic device: three dimensional numerical model for fluidic device is developed, and numerical results are compared with experimental data obtained at KAERI in order to verify numerical simulation. In addition, variation of flow rate is investigated at various elapsed times after valve operating, and flow characteristics is analyzed at low and high flow rate conditions, respectively.

  16. Analysis of Condensation Phenomena in PAFS (Passive Auxiliary Feedwater System) Horizontal Heat Exchanger of APR+

    International Nuclear Information System (INIS)

    APR+ (Advanced Power Reactor Plus) is the next generation nuclear power plant in Korea. It adopts PAFS (Passive Auxiliary Feedwater System) on the secondary system. It can replace the conventional active system for auxiliary feedwater injection to the steam generator, and it enable to supply the coolant by a passive system. It cools down the secondary system by heat transfer at a horizontal U-tube in PCCT (Passive Condensate Cooling Tank). High pressure steam flow from the steam generator is condensed in the horizontal heat exchanger. The water in PCCT is maintained at an atmospheric pressure, so that boiling heat transfer at the outside wall of heat exchanger and natural convection occur in PCCT pool. The heat exchanger and PCCT is higher than steam generator, so condensate can be drained and injected to feedwater system without any active system. This study aims at design of the horizontal heat exchanger in PAFS. It should remove the heat generated in the steam generator. To satisfy this requirement, a system code analysis is conducted. The amount of condensation heat transfer is investigated by MARS (Multi-dimensional Analysis for Reactor Safety) code analysis

  17. Experimental program for validation of cooling and operational performance of the APR+ Passive auxiliary feedwater system

    International Nuclear Information System (INIS)

    PAFS (Passive Auxiliary Feedwater System) is one of the advanced passive safety systems adopted in the APR+ (Advanced Power Reactor plus), which is intended to completely replace the conventional active auxiliary feedwater system. PAFS cools down the steam generator's secondary side, and eventually removes the decay heat from the reactor core by introducing a natural driving force mechanism; i.e., condensing steam in nearly horizontal U-tubes submerged inside the passive condensation cooling tank (PCCT). With an aim of validating the cooling and operational performance of the PAFS, an experimental program is in progress at KAERI (Korea Atomic Energy Research Institute), which is composed of two kinds of tests; the separate effect test and the integral effect test. The separate effect test, PASCAL (PAFS Condensing Heat Removal Assessment Loop), is in progress to experimentally investigate the condensation heat transfer and natural convection phenomena in PAFS. The integral effect test is being performed to confirm the operational performance of the PAFS coupled with the other reactor coolant systems (RCS) using the thermal hydraulic integral effect test facility, ATLAS (Advanced Thermal hydraulic test Loop for Accident Simulation). This paper summarizes the up to date experimental results of the separate effect test and the integral effect test for PAFS from a cooling and operational performance point of view

  18. Preliminary Performance Analysis on APR+ PAFS Using RELAP5 and MARS Codes

    International Nuclear Information System (INIS)

    International nuclear industry has been adopting a passive safety system to enhance safety and reliability of nuclear power plant with advanced technology. Domestic industry has been also developing a specific advanced reactor, so-called advanced power reactor plus (APR+), with passive auxiliary feedwater system (PAFS). The PAFS was introduced to replace an active auxiliary feedwater system (AFWS) completely. The system function is to remove the residual heat in the primary system like the AFWS does when the main feedwater system is unavailable. PAFS consists of a passive condensate cooling tank (PCCT), a heat exchanger, valves, and pipes as shown in Fig. 1. When PAFS works, steam from steam generator is supplied and condensed into water in the heat exchange. And the water falls down by gravity and returns to the steam generator. This progress goes on repeatedly and it makes natural circulation possible in the system. The circulating flow removes continuously the primary residual heat without any active components. The performance of PAFS depends on various thermo-hydraulic (TH) phenomena occurred in the system. So understanding these phenomena is required to analyze its performance with TH code such as RELAP5 or MARS which is a regulatory audit code. Licensee in the domestic industry has been conducting the performance analysis of the PAFS with RELAP5. So the analysis of MARS model with the same input was carried out and difference between two codes was compared in this study

  19. A Framework to Measure Operator's Workload in Main Control Room of APR1400

    International Nuclear Information System (INIS)

    Though the work of operators has been changed a great deal, due to a lack of appropriate guidelines on the role allocation or communication method of operators, the problem of a lopsided workload for each operator has been raised. Thus, it is necessary to enhance the operation capability by developing the guidelines on the role definition and communication of operators in the advanced MCR of NPPs. To resolve this problem, however, a method of measuring the workload according to work execution of operators is necessary, but the applicable method is not available at this time. The objective of this research is to develop an analytical framework to evaluate the workload according to the work execution of power plant operators. A framework to measure the workload of crews in an advanced main control room has been suggested. In this research, we proposed a framework to measure and evaluate the workload of operators in an advanced MCR and the workload was measured through the simulator training experiment of the MCR of an APR1400. On the basis of these observations, it is necessary to reestablish the role and communication method of MCR operators suitable to the new operational environment and changed work and develops the appropriate operating guidelines

  20. Sensitivity Analysis of Ex-Vessel Steam Explosion usion TEXAS-V code for APR1400

    International Nuclear Information System (INIS)

    This study conducted the influence of melt velocity and melt diameter on the steam explosion calculation. There was strong influence of the jet diameter and velocity on the explosion. If there is the maximum pressure at the walls, the steam explosion loads can be too high to resist on the cavity wall. In the future study, TEXAS-V code will be used to evaluate the impact of various uncertainties to provide a conservative envelope for the steam explosion. In severe accidents, the corium can come into contact with coolant either when it flows to the bottom of the reactor vessel and encounters the reactor coolant, or when it breaches the reactor vessel and flows into the reactor containment. A steam explosion could then weaken the containment structures, such as the reactor vessel or the concrete walls of the containment building. The purpose of this study is to calculate using TEXAS-V code for ex-vessel steam explosion for a flooded reactor cavity of APR1400. TEXAS-V code to analyze and predict the ex-vessel steam explosion for a reactor scale is used

  1. Preliminary Performance Analysis on APR+ PAFS Using RELAP5 and MARS Codes

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyung Jin; Hong, Soon Joon [FNC Tech., SNU, Seoul (Korea, Republic of); Park, Ju Yeop; Seul, Kwang Won [KINS, Daejeon (Korea, Republic of)

    2010-10-15

    International nuclear industry has been adopting a passive safety system to enhance safety and reliability of nuclear power plant with advanced technology. Domestic industry has been also developing a specific advanced reactor, so-called advanced power reactor plus (APR+), with passive auxiliary feedwater system (PAFS). The PAFS was introduced to replace an active auxiliary feedwater system (AFWS) completely. The system function is to remove the residual heat in the primary system like the AFWS does when the main feedwater system is unavailable. PAFS consists of a passive condensate cooling tank (PCCT), a heat exchanger, valves, and pipes as shown in Fig. 1. When PAFS works, steam from steam generator is supplied and condensed into water in the heat exchange. And the water falls down by gravity and returns to the steam generator. This progress goes on repeatedly and it makes natural circulation possible in the system. The circulating flow removes continuously the primary residual heat without any active components. The performance of PAFS depends on various thermo-hydraulic (TH) phenomena occurred in the system. So understanding these phenomena is required to analyze its performance with TH code such as RELAP5 or MARS which is a regulatory audit code. Licensee in the domestic industry has been conducting the performance analysis of the PAFS with RELAP5. So the analysis of MARS model with the same input was carried out and difference between two codes was compared in this study

  2. Analysis of Condensation Phenomena in PAFS (Passive Auxiliary Feedwater System) Horizontal Heat Exchanger of APR+

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Byoung Uhn; Yun, Byong Jo; Bae, Sung Won; Choi, Ki Yong; Song, Chul Hwa [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Cheon, Jong [Korea Hydro and Nuclear Power Co., Daejeon (Korea, Republic of)

    2009-10-15

    APR+ (Advanced Power Reactor Plus) is the next generation nuclear power plant in Korea. It adopts PAFS (Passive Auxiliary Feedwater System) on the secondary system. It can replace the conventional active system for auxiliary feedwater injection to the steam generator, and it enable to supply the coolant by a passive system. It cools down the secondary system by heat transfer at a horizontal U-tube in PCCT (Passive Condensate Cooling Tank). High pressure steam flow from the steam generator is condensed in the horizontal heat exchanger. The water in PCCT is maintained at an atmospheric pressure, so that boiling heat transfer at the outside wall of heat exchanger and natural convection occur in PCCT pool. The heat exchanger and PCCT is higher than steam generator, so condensate can be drained and injected to feedwater system without any active system. This study aims at design of the horizontal heat exchanger in PAFS. It should remove the heat generated in the steam generator. To satisfy this requirement, a system code analysis is conducted. The amount of condensation heat transfer is investigated by MARS (Multi-dimensional Analysis for Reactor Safety) code analysis.

  3. Organizacijos aprūpinimo darbuotojais veiklų gerinimas gamybinės įmonės pavyzdžiu

    OpenAIRE

    Varnaitė, Evelina

    2008-01-01

    Darbas sudarytas iš trijų dalių. Pirmoje dalyje analizuojama Lietuvos ir užsienio mokslininkų suformuluota organizacijos aprūpinimo darbuotojais veiklų samprata, turinys, metodai, subjektai bei veiksniai, įtakojantys šias veiklas. Antrojoje dalyje pateikiami ir analizuojami tyrimo metu surinkti duomenys apie gamybinėje įmonėje atliekamas aprūpinimo darbuotojais veiklas. Analizė leido padaryti išvadą, kad įmonėje atliekamos aprūpinimo darbuotojais veiklos turi trūkumų. Todėl trečioje dalyje yr...

  4. Organizacijos aprūpinimu personalu veiklų tobulinimas ŽŪB „Nematekas“ pavyzdžiu

    OpenAIRE

    Matelytė, Giedrė

    2013-01-01

    Baigiamojo darbo tikslas – atlikti ŽŪB „Nematekas“ aprūpinimo personalu veiklų analizę ir pateikti projektinius sprendimus darbuotojų planavimo, verbavimo, atrankos ir adaptavimo procesams. Baigiamajame darbe atlikta personalo veiklų sampratos teorinė analizė. Atliekama personalo valdymo informacinio aprūpinimo veiklų, organizacijos aprūpinimo darbuotojais ir darbuotojų efektyvaus panaudojimo ir išlaikymo veiklų analizė. Analitinė darbo dalyje naudojami keturi tyrimo metodai: mokslinės litera...

  5. Single port-assisted fully laparoscopic abdominoperineal resection (APR) with immediate V-RAM flap reconstruction of the perineal defect.

    LENUS (Irish Health Repository)

    Ali, Sayid

    2012-09-01

    Abdominoperineal resection (APR) of anorectal cancers after neoadjuvant chemoradiotherapy may incur significant perineal morbidity. While vertical rectus abdominis muscle (V-RAM) flaps can fill the pelvic resection space with health tissue, their use has previously been described predominantly in association with laparotomy. Here, we describe a means of combination laparoscopic APR with V-RAM flap reconstruction that allows structural preservation of the entire abdominal wall throughout the oncological resection and of the deep parietal layers after V-RAM donation. Furthermore, a single port access device used at the end colostomy site allows a second senior surgeon assist with an additional two working instruments for the purpose of improved pelvic tissue retraction, especially useful in obese patients.

  6. Moderne Chirurgie der Leisten- und Narbenhernie

    OpenAIRE

    Lauscher, Johannes Christian

    2014-01-01

    Inguinal and incisional hernias belong to the most frequent diseases in general surgery. Our studies show a relevant change of the surgical treatment of inguinal hernias in the last 15 years. Repair with mesh has become standard, the rate of outpatient surgery is rising and the length of hospital stay of the inpatients is decreasing. The recurrence rate could be reduced due to mesh repair but the rate of chronic groin pain and dysesthesia after inguinal hernia repair is relevant. Minimal i...

  7. Scoping Test on the Effects of Boron and Buffer in the Mockup PLUS7 Fuel Assembly of the APR1400

    Energy Technology Data Exchange (ETDEWEB)

    Suh, Jeong Kwan; Kwon, Sun Guk; Kim, Jae Won; Lee, Jae Yong [KHNP Central Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    Test results of the repeatability and the boron/buffer effects are presented, and compared with the acceptance basis for the LTCC of the APR1400. To address GSI-191 of the APR1400, we have performed a series of FA tests using a mockup PLUS7. The test results of repeatability performed at limiting conditions meet the acceptance basis compared with the reference results (SK34-61∼64) within 7% difference. Boron and buffer in the fluid lowered pressure drop across the entire FA compared with the condition without them. The test results of boron and buffer effects meet the acceptance head loss (91.8 kPa) of the APR1400 with a sufficient margin. To address U. S. Nuclear Regulatory Commission (NRC) Generic Safety Issue (GSI)-191, we have performed a series of fuel assembly (FA) head loss tests. The goal of this test is to confirm that there is sufficient available head when the debris reaches the core inlets of the APR1400 during a loss-of-coolant accident (LOCA), and that the long-term core cooling (LTCC) is not impeded. To move forward with the resolution of GSI-191 in-vessel effects, we have performed a scoping test on the effects of boron and buffer at ambient temperature. In test SK34-205, repeatability of the tests was confirmed at the limiting conditions. In a scoping test SK34-245, boron and Tri-Sodium Phosphate (TSP) buffer were added prior to the debris addition.

  8. Developing Optimal Procedure of Emergency Outside Cooling Water Injection for APR1400 Extended SBO Scenario Using MARS Code

    International Nuclear Information System (INIS)

    In this study, we examined optimum operator actions to mitigate extended SBO using MARS code. Particularly, this paper focuses on analyzing outside core cooling water injection scenario, and aimed to develop optimal extended SBO procedure. Supplying outside emergency cooling water is the key feature of flexible strategy in extended SBO situation. An optimum strategy to maintain core cooling is developed for typical extended SBO. MARS APR1400 best estimate model was used to find optimal procedure. Also RCP seal leakage effect was considered importantly. Recent Fukushima accident shows the importance of mitigation capability against extended SBO scenarios. In Korea, all nuclear power plants incorporated various measures against Fukushima-like events. For APR1400 NPP, outside connectors are installed to inject cooling water using fire trucks or portable pumps. Using these connectors, outside cooling water can be provided to reactor, steam generators (SG), containment spray system, and spent fuel pool. In U. S., similar approach is chosen to provide a diverse and flexible means to prevent fuel damage (core and SFP) in external event conditions resulting in extended loss of AC power and loss of ultimate heat sink. Hence, hardware necessary to cope with extended SBO is already available for APR1400. However, considering the complex and stressful condition encountered by operators during extended SBO, it is important to develop guidelines/procedures to best cope with the event

  9. Evaluation of the APR+ Passive Auxiliary Feedwater System Performance during Main Feedwater Line Break Accident using MARS-KS

    International Nuclear Information System (INIS)

    Ever since the Nuclear Power Plant (NPP) started commercial operation, advanced NPPs have been developed to enhance performance and safety as well as the economics of the plant. As a part of a regulatory safety research of the advanced nuclear reactors, MARS-KS regulatory safety analysis code has been selected to evaluate the performance of the Passive Auxiliary Feedwater System (PAFS) during Main Feedwater Line Break (MFLB) accident of the APR+ (Advanced Power Reactor+) which is under development by Korea Hydro and Nuclear Power (KHNP). The results of the APR+ MFLB analysis and the performance of the PAFS are presented herein. MATS-KS MFLB analysis shows that the MARS-KS code well simulates dynamic thermal hydraulic behavior of the MFLB and maximum RCS pressure satisfies the acceptance criteria of 120% design RCS pressure for the MFLB accident. APR+ PAFS effectively removes the core decay heat by the natural circulation during the MFLB accidents, however, comprehensive performance of the PAFS should be evaluated against the design basis of 8 hours core heat removal until the conditions for the initiation of the Shutdown Cooling System (350 .deg. F and 400 psia) are met

  10. Evaluation of the APR+ Passive Auxiliary Feedwater System Performance during Main Feedwater Line Break Accident using MARS-KS

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Minjeong; Ralph, Marigomena; Sim, S. K. [Environment and Energy Technology, Inc., Daejeon (Korea, Republic of); Bang, Youngseok [KINS, Daejeon (Korea, Republic of)

    2013-05-15

    Ever since the Nuclear Power Plant (NPP) started commercial operation, advanced NPPs have been developed to enhance performance and safety as well as the economics of the plant. As a part of a regulatory safety research of the advanced nuclear reactors, MARS-KS regulatory safety analysis code has been selected to evaluate the performance of the Passive Auxiliary Feedwater System (PAFS) during Main Feedwater Line Break (MFLB) accident of the APR+ (Advanced Power Reactor+) which is under development by Korea Hydro and Nuclear Power (KHNP). The results of the APR+ MFLB analysis and the performance of the PAFS are presented herein. MATS-KS MFLB analysis shows that the MARS-KS code well simulates dynamic thermal hydraulic behavior of the MFLB and maximum RCS pressure satisfies the acceptance criteria of 120% design RCS pressure for the MFLB accident. APR+ PAFS effectively removes the core decay heat by the natural circulation during the MFLB accidents, however, comprehensive performance of the PAFS should be evaluated against the design basis of 8 hours core heat removal until the conditions for the initiation of the Shutdown Cooling System (350 .deg. F and 400 psia) are met.

  11. Drop size measurements and entrainment in APR1400 during LBLOCA reflood phase

    International Nuclear Information System (INIS)

    A study has been performed to investigate droplet size in the nuclear reactor of APR1400 during LBLOCA reflood phase and to develop droplet entrainment and deposition models for SPACE (Safety and Performance CodE) which is a safety analysis tool for PWR being developed in Korea. A freezing technique for measuring the size of droplets was developed to obtain the droplet size distribution in horizontal annular flow in a pipe with a 37.1 mm diameter. Droplets are frozen by using an extremely low temperature nitrogen gas with liquid film extraction. They are then photographed with a microscope and a CCD camera and measured by means of an image process. The results are compared with various experimental data. The droplet sizes measured by the freezing technique are comparable with those measured by other methods at a high superficial air velocity (of 50 m/s). However, because of the film extraction problem, the droplet sizes measured at a low superficial air velocity of less than 40 m/s are higher than those measured by other methods. A present method suggested for predicting the Sauter mean diameter is based on the maximum droplet size correlation for the experimental data, with and without liquid film extraction. The average droplet size is remarkably smaller downstream of the liquid film extractor because large droplets from the liquid film are excluded. In order to understand and to predict a heat transfer between superheated steam and droplets properly during reflood phase of LBLOCA, it is very important to measure broken droplet sizes by spacer grids. A study, therefore, has been performed to investigate droplet size in rod bundles with spacer grids and to develop a spacer grid droplet breakup model for safety analysis codes. Experiments were conducted with liquid droplets (SMD of 300∼700 μm) and various spacer grids at superficial air velocity of 10 m/s and 20 m/s based on FLECHT SEASET. The test channel and the grids were heated to 150 .deg. C to prevent

  12. Review on the NEI Methodology of Debris Transport Analysis in Sump Blockage Issue for APR1400

    International Nuclear Information System (INIS)

    Since USNRC (United State Nuclear Regulatory Committee) initially addressed post-accident sump performance under Unresolved Safety Issue USI A-43, sump blockage issue has gone through GSI-191, Regulation Guide 1.82, Rev. 3 (RG. 1.82 Rev.3), and generic Letter 2004-02 for PWRs (Pressurized Water Reactors). As a response of these USNRC's activities, NEI 04-07 was issued in order to evaluate the post-accident performance of a plant's recirculation sump. The baseline methodology of NEI 04-07 is composed of break selection, debris generation, latent debris, debris transport, and head loss. In analytical refinement of NEI 04-07, computational fluid dynamic (CFD) is suggested for the evaluation of debris transport in emergency core cooling (ECC) recirculation mode as guided by RG. 1.82 Rev.3. In Korea nuclear industry also keeps step with international activities of this safety issue, with Kori 1 plant as a pioneering edge. Korean nuclear industry has been also pursuing development of an advanced PWR of APR1400, which incorporates several improved safety features. One of the key features, considering sump blockage issue, is the adoption of IRWST (In-containment Refueling Water Storage Tank). This device, as the acronym implies, changes the emergency core cooling water injection pattern. This fact makes us to review the applicability of NEI 04-07's methodology. In this paper we discuss the applicability of NEI 04- 07's methodology, and more over, new methodology is proposed. And finally the preliminary debris transport is analyzed

  13. Steady state flow evaluations for passive auxiliary feedwater system of APR

    International Nuclear Information System (INIS)

    This paper briefly introduces a methodology to evaluate steady state flow of APR+ Passive Auxiliary Feedwater System (PAFS). The PAFS is being developed as a safety grade passive system to completely replace the existing active Auxiliary Feedwater System (AFWS). Natural circulation cooling can be generally classified into the single-phase, two-phase, and boiling-condensation modes. The PAF is designed to be operated in a boiling-condensation natural circulation mode. The steady-state flow rate should be equal to the steady-state boiling/condensation rate determined by the steady-state energy and momentum balances in the PAFS. The determined steady-state flow rate can be used in the design optimization for the natural circulation loop of the PAFS through the steady-state momentum balance. Since the retarding force, which is to be balanced by the driving force in the natural circulation system design depends on the reliable evaluation of the success of a natural circulation system design depends on the reliable evaluation of the pressure loss coefficients. In PAFS, the core decay heat is released by natural circulation flow between the S G secondary side and the Passive Condensation Heat Exchanger (PCHX) that is immersed in the Passive Condensation Cooling Tank (PCCT). The PCCT is located on the top of Auxiliary building The driving force is determined by the difference between the S/G (heat Source) secondary water level and condensation liquid (heat sink) level. It will overcome retarding force at flowrate in the system, which is determined by vaporization and condensation of the steam which is generated at the S/G by the latent heat in system. In this study, the theoretical method to estimate the steady state flow rate in boiling-condensation natural circulation system is developed and compared with test results

  14. Integral experiment and RELAP5 analysis for DVI line break SBLOCA in APR1400

    International Nuclear Information System (INIS)

    The thermal-hydraulic phenomena of Direct Vessel Injection (DVI) line Small-Break Loss-of-Coolant Accident (SBLOCA) in the pressurized water reactor, APR1400, were investigated. To understand the thermal-hydraulic phenomena during the SBLOCA transient, the reduced-height and reduced-pressure integral test loop, SNUF (Seoul National University Facility), was constructed according to the energy scaling methodology. The methodology conserves the mass inventory and energy of the system in the same time scale as the prototype. From the RELAP5 analysis, the energy scaling methodology was confirmed to show the reasonable transient when ideally scaled-down SNUF model was compared to the prototype model. In order to overcome the limitation of power in actual SNUF, the modified-power curve was utilized without simulating the forced flow by pump, so that those corrections did not affect the major phenomena during transient. Geometric distortion of actual SNUF also did not strongly disturb the thermal-hydraulic behaviors, especially occurrence of the downcomer seal clearing. In the experiments according to the conditions determined by energy scaling methodology, the phenomenon of downcomer seal clearing had a dominant role in decrease of the system pressure and increase of the coolant level of core. It occurred when the steam injected from cold legs penetrated the coolant in upper downcomer toward the broken DVI line. The experimental results was used to validate the calculation capability of RELAP5, especially for the downcomer seal clearing phenomenon, and to estimate the scale-up capability of RELAP5 code according to the scaling methodology. (authors)

  15. Analysis of severe accident progression for in-vessel corium retention estimation in the APR 1400

    International Nuclear Information System (INIS)

    The scope and content of this technical report is to evaluate high-pressure transients of total Loss of Feed Water (LOFW) to the steam generators and Station Blackout (SBO), and low-pressure transients of Loss of Coolant Accident (LOCA) without Safety Injection (SI) using the SCDAP/RELAP5/MOD3.3 computer code from transient initiation to reactor vessel failure in the APR 1400. The SCDAP/RELAP5/MOD3.3 results have shown that the pressurizer surge line had failed before reactor vessel failure, which results in a rapid decrease of RCS pressure in the high-pressure sequences of the LOFW and the SBO transients. The LOFW with intentional RCS depressurization using the safety depressurization system prevents failure of the pressurizer surge line and results in actuation of the safety injection tanks. A large mass of the melted and relocated core material in the bottom of core region at approximately 6 hours was relocated to the lower plenum of the reactor vessel in the 2-inch and the 3-inch SBLOCAs, which results in the reactor vessel failure by creep. In the SBLOCA sequence without the safety injection, the actuation of the SITs can be possible for the operator to have time of 4-5 hours in the action of the severe accident mitigation strategy to prevent reactor vessel failure. In all sequences, approximately 50-90 % of the core material was melted and relocated to the lower plenum of the reactor vessel at the time of reactor vessel failure and approximately 30-60 % of the fuel rod cladding was oxidized

  16. Experiment and RELAP5 analysis for the downcomer boiling of APR1400 under LBLOCA

    International Nuclear Information System (INIS)

    Experiment has been carried out to investigate the boiling phenomena in the downcomer and RELAP5/MOD3.2 has been assessed with the present experimental data. The heated wall with a thickness of 8.2 cm and a height of 27 cm is used, which is made of the same material as the prototype (APR1400) with chrome coating against rusting. From the experiment, we visually observed strong liquid recirculation and vapor jetting near the heated wall due to the axial migration of voids only in the thin layer of the heated wall but little bubble migration to the bulk region. The size of the thin layer is about 4 cm, which is used for the determination of the radial nodal size in the radial double-node schemes. The RELAP5 calculations using three different nodal schemes are compared with experimental data in aspects of water level, void fraction, wall temperatures and phase velocities. The radial single-node scheme produces no liquid recirculation, resulting in the sudden level drop due to a sudden increase in void fraction. The double-nodal scheme with the top-bottom radial connections yields the strong circulation, eliminating the sudden level drop. As a result, the scheme produces better results than the radial single-nodal scheme and the double-nodal scheme with all radial connections. Based on the information from the measurement of local liquid velocity profile and visual observation, the drift velocity model is developed to apply into the downcomer with a large gap and a vertical heated wall. The proposed drift velocity model has been implemented into RELAP5 and verified with the experimental results. (author)

  17. Cold-Leg Small Break LOCA Analysis of APR1400 Plant Using a SPACE/sEM Code

    International Nuclear Information System (INIS)

    The Small Break Loss-of-Coolant Accident (SBLOCA) evaluation methodology (EM) for APR1400, called sEM, is now being developed using SPACE code. SPACE/sEM is to set up a conservative evaluation methodology in accordance with appendix K of 10 CFR 50. Major required and acceptable features of the evaluation models are described as below. - Fission product decay : 1.2 times of ANS97 decay curve - Critical flow model : Henry-Fauske Moody two phase critical flow model - Metal-Water reaction model : Baker-Just equation - Critical Heat Flux (CHF) : B and W, Barnett and Modified Barnett correlation - Post-CHF : Groeneveld 5.7 film boiling correlation A series of test matrix is established to validate SPACE/sEM code in terms of major SBLOCA phenomena, e.g. core level swelling and boiling, core heat transfer, critical flow, loop seal clearance and their integrated effects. The separated effect tests (SETs) and integrated effect tests (IETs) are successfully performed and these results shows that SPACE/sEM code has a conservatism comparing with experimental data. Finally, plant calculations of SBLOCA for APR1400 are conducted as described below. - Break location sensitivity : DVI line, hot-leg, cold-leg, pump suction leg. - Break size spectrum : 0.4ft2∼0.02ft2(DVI) 0.5ft2∼0.02ft2(hot-leg, cold-leg, pump suction leg) This paper deals with break size spectrum analysis of cold-leg break accidents. Based on the calculation results, emergency core cooling system (ECCS) performances of APR1400 and typical SBLOCA phenomena can be evaluated. Cold-leg SBLOCA analysis for APR1400 is performed using SPACE/sEM code under harsh environment condition. SPACE/sEM code shows the typical SBLOCA behaviors and it is reasonably predicted. Although SPACE/sEM code has conservative models and correlations based on appendix K of 10 CFR 50, PCT does not exceed the requirement (1477 K). It is concluded that ECCS in APR1400 has a sufficient performance in cold-leg SBLOCA

  18. Development of an amphibious robot for visual inspection of APR1400 Npp IRWST strainer

    International Nuclear Information System (INIS)

    An amphibious inspection robot system (hereafter AIROS) is being developed to visually inspect the in-containment refueling storage water tank (hereafter IRWST) strainer in APR1400 instead of a human diver. Four IRWST strainers are located in the IRWST, which is filled with boric acid water. Each strainer has 108 sub-assembly strainer fin modules that should be inspected with the VT-3 method according to Reg. guide 1.82 and the operation manual. AIROS has 6 thrusters for submarine voyage and 4 legs for walking on the top of the strainer. An inverse kinematic algorithm was implemented in the robot controller for exact walking on the top of the IRWST strainer. The IRWST strainer has several top cross braces that are extruded on the top of the strainer, which can be obstacles of walking on the strainer, to maintain the frame of the strainer. Therefore, a robot leg should arrive at the position beside the top cross brace. For this reason, we used an image processing technique to find the top cross brace in the sole camera image. The sole camera image is processed to find the existence of the top cross brace using the cross edge detection algorithm in real time. A 5-DOF robot arm that has multiple camera modules for simultaneous inspection of both sides can penetrate narrow gaps. For intuitive presentation of inspection results and for management of inspection data, inspection images are stored in the control PC with camera angles and positions to synthesize and merge the images. The synthesized images are then mapped in a 3D CAD model of the IRWST strainer with the location information. An IRWST strainer mock-up was fabricated to teach the robot arm scanning and gaiting. It is important to arrive at the designated position for inserting the robot arm into all of the gaps. Exact position control without anchor under the water is not easy. Therefore, we designed the multi leg robot for the role of anchoring and positioning. Quadruped robot design of installing sole

  19. Development of an amphibious robot for visual inspection of APR1400 Npp IRWST strainer

    Energy Technology Data Exchange (ETDEWEB)

    Jang, You Hyun; Kim, Jong Seog [Korea Hydro Nuclear Power Central Research Institute, Daejeon (Korea, Republic of)

    2014-06-15

    An amphibious inspection robot system (hereafter AIROS) is being developed to visually inspect the in-containment refueling storage water tank (hereafter IRWST) strainer in APR1400 instead of a human diver. Four IRWST strainers are located in the IRWST, which is filled with boric acid water. Each strainer has 108 sub-assembly strainer fin modules that should be inspected with the VT-3 method according to Reg. guide 1.82 and the operation manual. AIROS has 6 thrusters for submarine voyage and 4 legs for walking on the top of the strainer. An inverse kinematic algorithm was implemented in the robot controller for exact walking on the top of the IRWST strainer. The IRWST strainer has several top cross braces that are extruded on the top of the strainer, which can be obstacles of walking on the strainer, to maintain the frame of the strainer. Therefore, a robot leg should arrive at the position beside the top cross brace. For this reason, we used an image processing technique to find the top cross brace in the sole camera image. The sole camera image is processed to find the existence of the top cross brace using the cross edge detection algorithm in real time. A 5-DOF robot arm that has multiple camera modules for simultaneous inspection of both sides can penetrate narrow gaps. For intuitive presentation of inspection results and for management of inspection data, inspection images are stored in the control PC with camera angles and positions to synthesize and merge the images. The synthesized images are then mapped in a 3D CAD model of the IRWST strainer with the location information. An IRWST strainer mock-up was fabricated to teach the robot arm scanning and gaiting. It is important to arrive at the designated position for inserting the robot arm into all of the gaps. Exact position control without anchor under the water is not easy. Therefore, we designed the multi leg robot for the role of anchoring and positioning. Quadruped robot design of installing sole

  20. Analysis of MSGTR events for APR1400 by means of best estimate thermal-hydraulic system code

    International Nuclear Information System (INIS)

    A multiple steam generator tube rupture (MSGTR) event has never occurred in the history of commercial nuclear reactor operation while single steam generator tube rupture (SGTR) event is reported to occur every two years. As there is no history of MSGTR event, the understandings of transients and consequences of this event are not so much. In this study, a postulated MSGTR event in advanced power reactor 1400 (APR1400) is analyzed using thermal-hydraulic system code. The APR 1400 is a two-loop, 1000 MWe, PWR supposed to be built in 2009. MARS1.4 is used in this study. The present study aims to understand the effects of rupture location in heat transfer tubes and selection of affected steam generator following a MSGTR event. The effects of five tube rupture locations are compared with each other. The comparison shows that the response of APR1400 is to allow shortest time for operator action following a tubes rupture in the vicinity of hot-leg side tube sheet and to allow longest time following a tube ruptures at the tube top. The MSSV lift time for rupture at tube-top is evaluated as 24.5% larger than that for rupture at hot-leg side tube sheet. Also, the MSSV lift time for four cases are compared in order to examine how long operator response time is allowed depending on which steam generator is affected. The comparison shows that the cases for both of two steam generators are affected allow longer time for operator action compared with the cases that a single steam generator is affected. Further more, the tube ruptures in the steam generator where a pressurizer is linked leads to the shortest operator response time

  1. Regulation of enterobactin iron transport in Escherichia coli: characterization of ent::Mu d(Apr lac) operon fusions.

    OpenAIRE

    Fleming, T P; Nahlik, M S; McIntosh, M A

    1983-01-01

    The vector Mu d(Apr lac) was utilized to construct operon fusions in the Escherichia coli enterobactin (ent) biosynthetic and transport genes. Enzyme assays indicated a 5- to 15-fold increase in the expression of beta-galactosidase when the fusion strains were grown under iron-deficient conditions. The polarity effects seen by Mu d insertions into entA, entC, and entE were consistent with a single operon, entA(CGB)E. The direction of transcription from iron-regulated promoters was determined ...

  2. Pastato aprūpinimas šiluma šilumos siurbliu su šiluminiu poliumi

    OpenAIRE

    Žostautas, Mauricijus

    2012-01-01

    Baigiamajame magistro darbe nagrinėjamas pastato, aprūpinimas šiluma šilumos siurbliu su šiluminiais poliais. Yra apžvelgtos esamos giliosios bei sekliosios geoterminės energijos panaudojimo panaudojimo galimybės Lietuvoje. Aprašytos prielaidos ir supaprastinimai šiluminių polių skaičiavimui, aprašytos skaičiavimo metodikos. Atlikti šiluminių polių skaičiavimai, naudojantis penkiomis metodikomis. Aprašytas pasirinktas pastatas, apskaičiuoti atitvarų šiluminiai rodikliai, nustatyta pastatui re...

  3. Kvartalo/objekto aprūpinimo šilumine energija variantų analizė

    OpenAIRE

    Pladas, Karolis

    2014-01-01

    Magistro baigiamajame darbe aptariamas Lietuvos ir Europos Sąjungos šalių energetikos sektorius. Apžvelgiamos direktyvos, strategijos, plėtros planai bei teisės aktai skirti energetikos plėtojimui šalyje. Tiriamuoju objektu pasirenkama Trakų Vokės katilinė, kuri aprūpina šiluma kvartalą degindama gamtines dujas vandens šildymo katiluose. Šiame darbe yra nagrinėjamos penkios alternatyvos: kogeneratorius ir dujiniai katilai, kogeneratorius su akumuliacine talpa ir dujiniais katilais, kogenerato...

  4. Multi-analytical characterisation of D’Aprés Cormon by José Veloso Salgado

    Energy Technology Data Exchange (ETDEWEB)

    Cardeira, A.M. [Faculdade de Belas-Artes da Universidade de Lisboa, Largo da Academia Nacional de Belas-Artes, 1249-058 Lisboa (Portugal); Centro de Física Atómica da Universidade de Lisboa, Av. Professor Gama Pinto 2, 1649-003 Lisboa (Portugal); Longelin, S. [Centro de Física Atómica da Universidade de Lisboa, Av. Professor Gama Pinto 2, 1649-003 Lisboa (Portugal); Costa, S.; Candeias, A. [Laboratório José de Figueiredo, Direcção Geral do Património Cultural, Rua das Janelas Verdes 37, 1249-018 Lisboa (Portugal); Laboratório HERCULES e Centro de Química de Évora, Universidade de Évora, Largo Marquês de Marialva 8, 7000 Évora (Portugal); Carvalho, M.L. [Centro de Física Atómica da Universidade de Lisboa, Av. Professor Gama Pinto 2, 1649-003 Lisboa (Portugal); Manso, M., E-mail: marta974@cii.fc.ul.pt [Centro de Física Atómica da Universidade de Lisboa, Av. Professor Gama Pinto 2, 1649-003 Lisboa (Portugal)

    2014-07-15

    This case study reveals the analytical characterisation carried out on ‘D’Aprés Cormon’ (1891) by Veloso Salgado, a copy of ‘Caïn’ (1880) by Fernando Cormon, belonging nowadays to Musée d’Orsay. Infrared Reflectography made in situ revealed underdrawing grid that was used to transpose the original painting to a smaller scale, pictorial style, execution method and retouched/restored areas. In situ EDXRF analysis together with Raman microscopy allowed the identification of gypsum, lead white, titanium white, yellow ochre, vermilion, ultramarine and lamp black. These results provide valuable information about the Salgado’s palette and his production technique.

  5. Multi-analytical characterisation of D’Aprés Cormon by José Veloso Salgado

    International Nuclear Information System (INIS)

    This case study reveals the analytical characterisation carried out on ‘D’Aprés Cormon’ (1891) by Veloso Salgado, a copy of ‘Caïn’ (1880) by Fernando Cormon, belonging nowadays to Musée d’Orsay. Infrared Reflectography made in situ revealed underdrawing grid that was used to transpose the original painting to a smaller scale, pictorial style, execution method and retouched/restored areas. In situ EDXRF analysis together with Raman microscopy allowed the identification of gypsum, lead white, titanium white, yellow ochre, vermilion, ultramarine and lamp black. These results provide valuable information about the Salgado’s palette and his production technique

  6. Thermal-Hydraulic Integral Effect Test Result on the Steam Generator Tube Rupture Accident in the APR1400

    International Nuclear Information System (INIS)

    A postulated SGTR (Steam Generator Tube Rupture) event of the APR1400 was experimentally investigated with the thermal-hydraulic integral effect test facility, ATLAS (Advanced Thermal-hydraulic Test Loop for Accident Simulation). It is generally known that the leak flow rate from the primary to the secondary side is the most important factor affecting the overall thermalhydraulic behaviors such as the depressurization rate of the RCS system, the water level increase and pressurization rate of the secondary system, and the consequent MSSV opening time, etc. As one of the most limiting SGTR accidents, a leak flow equivalent to a double-ended rupture of single and five U-tubes was simulated in this study. The main objectives of these tests were not only to provide physical insight into the system response of the APR1400 reactor during a transient situation of the SGTR but also to present integral effect test data for the validation of the SPACE (Safety and Performance Analysis Computer Code), which is now under development by the Korean nuclear industry

  7. A Bayesian inversion for slip distribution of 1 Apr 2007 Mw8.1 Solomon Islands Earthquake

    Science.gov (United States)

    Chen, T.; Luo, H.

    2013-12-01

    On 1 Apr 2007 the megathrust Mw8.1 Solomon Islands earthquake occurred in the southeast pacific along the New Britain subduction zone. 102 vertical displacement measurements over the southeastern end of the rupture zone from two field surveys after this event provide a unique constraint for slip distribution inversion. In conventional inversion method (such as bounded variable least squares) the smoothing parameter that determines the relative weight placed on fitting the data versus smoothing the slip distribution is often subjectively selected at the bend of the trade-off curve. Here a fully probabilistic inversion method[Fukuda,2008] is applied to estimate distributed slip and smoothing parameter objectively. The joint posterior probability density function of distributed slip and the smoothing parameter is formulated under a Bayesian framework and sampled with Markov chain Monte Carlo method. We estimate the spatial distribution of dip slip associated with the 1 Apr 2007 Solomon Islands earthquake with this method. Early results show a shallower dip angle than previous study and highly variable dip slip both along-strike and down-dip.

  8. Feed and Bleed Operation Analysis during Total Loss of Feedwater Accident for Supporting the PSA of APR+

    International Nuclear Information System (INIS)

    For estimating the safety of APR+ design, the probabilistic safety assessment (PSA) is performed. This paper discusses the minimum success criteria for successful feed and bleed procedure verified and decided when the secondary cooling is failed during Total loss of feedwater (TLOFW) accident. For verifying whether the equipment conditions proposed is enough to manage the transient event without core damage, the analysis is performed by RELAP5/MOD 3.3 code. During TLOFW event, the operator's action time is allowed for 80 minutes and the uncovered core could maintain the stable state for a long time, about a half or one hour by the positive effects given by the fast coolant circulation by RCP pump operation. In simulations considering test scenarios, the minimum required equipment for successful F and B managing during TLOFW without LOOP is verified that it is that F and B procedure could be performed successfully as if the operator would open at least one out of four POSRV within 80 minutes after secondary cooling failure for the RCS depressurization. These analysis results can be used for contribute more realistic and accurate performance of a APR+ PSA

  9. Evaluation of Steam and Gas-flow for APR1400 IRWST using GOTHIC 6.1b

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Mun Soo; Lee, Suk Ho; Kim, Han Gon [Korea Hydro and Nuclear Power Co., Daejeon (Korea, Republic of)

    2009-05-15

    The In-Containment Refueling Water Storage Tank (IRWST) of APR1400 is installed at the bottom of the containment building to promote the plant safety functions during an accident. This design feature brings about uncertainty factors that may necessitate improvement or revision of the conventional prediction of temperature and pressure of the containment building in the event of an accident. The hot steam that is released from a RCS break enters the IRWST through four Pressure Relief Dampers (PRDs). The steam is expected to be condensed with water stored in the IRWST, in which water is colder than the incoming steam. The purpose of this study is to investigate the influence of IRWST and PRDs on back pressure and temperature in APR1400 containment by utilizing a containment code: GOTHIC 6.1b (Generation of Thermal-Hydraulic Information for Containments). For this purpose, a multi-compartment and detailed three-dimensional model was developed to predict the steam and gas flow-rate in IRWST.

  10. Unit Risk Quotient (RQ) and Relative Significance of Radionuclide on Flora and Fauna to the EU-APR Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Keunsung [KHNP-CRI, Daejeon (Korea, Republic of); Kim, Sukhoon [FNC Technology Co., Ltd., Yongin (Korea, Republic of); Lee, Chonghui [KEPCO E and C, Yongin (Korea, Republic of)

    2015-05-15

    As part of the project for acquiring the certification from EUR organization, in accordance with Articles 4.8 and 5.5 specified in Section 2.20 of EUR Volume 2, the effects of ionizing radiation from the standard design of EU-APR on biota and ecosystems during operation and decommissioning phases shall be assessed. This assessment must be carried out according to the ERICA (i.e. Environmental Risk from Ionizing Contaminants: Assessment and management) integrated approach. This paper describes the evaluation results for unit risk quotient and relative significance by radionuclide derived from performing Tier 1 assessment on flora and fauna for the EU-APR design using ERICA Tool. As specified previously, Pa-231 and Th-228 are the most significant for the terrestrial and for the marine/freshwater ecosystems, respectively. And, in terms of environmental risk, those radionuclides having the most impact on flora and fauna are relatively more significant than isotope having the least impact by about 7 to 10 orders of magnitude.

  11. [Preparation and Identification of High Immunogenic A/PR/8/34 Maternal Strain HA Protein for Influenza Virus Classical Reassortment].

    Science.gov (United States)

    Tang, Jing; Xin, Li; Guo, Junfeng; Zhu, Wenfei; Zhang, Heyuan; Lang, Shaohui; Wang, Dayan; Shu, Yuelong

    2016-03-01

    Preparation of maternal strain A/PR/8/34 HA antiserum for influenza virus classical reassortment. A/PR/8/34 virus was digested by bromelain after inactivation and purification. 5%-20% sucrose continuous density gradient centrifugation method was used to purify HA protein. SIRD method was used to select the target protein. SDS-PAGE method was used to identified HA protein. High Immunogenic A/PR/8/34 HA protein was successfully prepared and HI titer reached 10240. High purity HA antiserum was identified by SIRD method. The key reagent in the classical reassortment of influenza virus was prepared, and the complete set of technical methods were explored, which laid the foundation for the independent research and development of seasonal influenza vaccine strains of China. PMID:27396155

  12. Evaluation of Effect of N{sub 2} Gas on the Cooling Capability of Passive Auxiliary Feedwater System (PAFS) in APR+

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Yun Je; Kang, Kyong Ho; Yun, Byong Jo [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2012-05-15

    In Korea, Advanced Power Reactor Plus (APR+) has being developed by adding passive safety features to Advanced Power Reactor 1400MWe (APR1400). Passive Auxiliary Feedwater System (PAFS) is one of passive system adopted in the APR+ to replace the conventional active auxiliary feedwater system. Because PAFS removes decay heat from the reactor core, it is required to verify the performance of PAFS in postulated accidents cases. In addition, an effect of noncondensable gas on the heat removal capability of PAFS should be evaluated since the non-condensable gas may deteriorate a condensation heat transfer through the condensation heat exchanger in PAFS. In this study, the effect of N{sub 2} gas was evaluated using MARS

  13. The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates.

    Directory of Open Access Journals (Sweden)

    Ruth M Kennan

    Full Text Available Many bacterial pathogens produce extracellular proteases that degrade the extracellular matrix of the host and therefore are involved in disease pathogenesis. Dichelobacter nodosus is the causative agent of ovine footrot, a highly contagious disease that is characterized by the separation of the hoof from the underlying tissue. D. nodosus secretes three subtilisin-like proteases whose analysis forms the basis of diagnostic tests that differentiate between virulent and benign strains and have been postulated to play a role in virulence. We have constructed protease mutants of D. nodosus; their analysis in a sheep virulence model revealed that one of these enzymes, AprV2, was required for virulence. These studies challenge the previous hypothesis that the elastase activity of AprV2 is important for disease progression, since aprV2 mutants were virulent when complemented with aprB2, which encodes a variant that has impaired elastase activity. We have determined the crystal structures of both AprV2 and AprB2 and characterized the biological activity of these enzymes. These data reveal that an unusual extended disulphide-tethered loop functions as an exosite, mediating effective enzyme-substrate interactions. The disulphide bond and Tyr92, which was located at the exposed end of the loop, were functionally important. Bioinformatic analyses suggested that other pathogenic bacteria may have proteases that utilize a similar mechanism. In conclusion, we have used an integrated multidisciplinary combination of bacterial genetics, whole animal virulence trials in the original host, biochemical studies, and comprehensive analysis of crystal structures to provide the first definitive evidence that the extracellular secreted proteases produced by D. nodosus are required for virulence and to elucidate the molecular mechanism by which these proteases bind to their natural substrates. We postulate that this exosite mechanism may be used by proteases produced by

  14. Monoclinically distorted perovskites, A2ZnTiO6 (A=Pr, Gd): Rietveld refinement, and dielectric studies

    International Nuclear Information System (INIS)

    Double perovskite related oxide A2ZnTiO6A=Pr, Gd were synthesized by the solid state reaction method at 1523 K. The structure and microstructure of the compounds were studied by X-ray, SAED and FESEM. Rietveld refinement of the powder X-ray analysis shows that the compounds crystallizes in monoclinic space group P21/n (a+b−b−) with unit cell parameter √2ap×√2ap×2ap (a=5.5026(1) Å, b=5.6305(1) Å, c=7.8149(1) Å, β=90.02(1)° for Pr2ZnTiO6 and a=5.3621(1) Å, b=5.6565(2) Å, c=7.6779(2) Å and β=90.264(2)° for Gd2ZnTiO6. Electron diffraction study confirms P21/n symmetry of the oxides. The monoclinic distortion is larger in Gd2ZnTiO6 than Pr2ZnTiO6 which is associated with the tolerance factor and the tilting angle of ZnO6 and TiO6 octahedra (ϕ=13.64° for Pr2ZnTiO6 and 16.51° for Gd2ZnTiO6). The compounds are highly ordered. The charge and size difference between B site cations are the driving force for the ordering of the B′O6 and B″O6 octahedra. Pr2ZnTiO6 shows a dielectric constant of 27 and dielectric loss of 0.003 while Gd2ZnTiO6 has a dielectric constant of 17 and dielectric loss of 0.005 measured at 1 MHz. - Graphical abstract: Synthesis of new double perovskite dielectric material with very low dielectric loss. - Highlights: • Synthesis of new monoclinically distorted double perovskite (Pr2ZnTiO6). • Synthesis of monoclinically distorted double perovskite (Gd2ZnTiO6). • Selected area electron diffraction study of A2ZnTiO6 (A=Pr, Gd). • Study of dielectric properties of A2ZnTiO6 (A=Pr, Gd)

  15. Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer

    OpenAIRE

    Fransson, Åsa; Glaessgen, Daria; Alfredsson, Jessica; Wiman, Klas G.; Bajalica-Lagercrantz, Svetlana; Mohell, Nina

    2016-01-01

    Background Mutation in the tumor suppressor gene TP53 is an early event in the development of high-grade serous (HGS) ovarian cancer and is identified in more than 96 % of HGS cancer patients. APR-246 (PRIMA-1MET) is the first clinical-stage compound that reactivates mutant p53 protein by refolding it to wild type conformation, thus inducing apoptosis. APR-246 has been tested as monotherapy in a Phase I/IIa clinical study in hematological malignancies and prostate cancer with promising result...

  16. Evolution a court terme des formes du phosphore d'un sol ferrallitique apres apports d'une boue urbaine

    OpenAIRE

    Brossard, M.; Mench, Michel; CLAIRON, Maurice; Laurent, J.Y.

    1991-01-01

    Une boue urbaine a été incorporée aux doses de 10 et 100 t (MS)●ha-1 dans l’horizon 0-20 cm d’un sol ferrallitique de Guadeloupe. L’expérimentation est conduite en microparcelles de plein champ pendant 500 j. Après prélèvement des échantillons de sol, les mottes de boue non fragmentées de taille supérieure à 5 mm sont triées manuellement. Les formes du phosphore du sol analysées sont les suivantes : phosphore total (Pt), organique (Po), minéral (Pm), extrait par un mélange bicarbonate-f...

  17. O après-coup e a reconsolidação da memória

    Directory of Open Access Journals (Sweden)

    Graziele Luiza Barizon Scopel Gerbasi

    2015-04-01

    Full Text Available Em diferentes áreas do conhecimento é reconhecido que a memória está sujeita a transformações ao longo do tempo. Partindo desse pressuposto, o objetivo do presente estudo é apresentar uma discussão compreendendo a ideia de que nossas recordações são suscetíveis a transformações e a concepção de après-coup. Há o delineamento de algumas ideias acerca da temporalidade em Psicanálise e do mecanismo de reconsolidação da memória segundo as Neurociências. Utilizando-se tais conceitos, evidenciou-se a viabilidade de se pensar uma interlocução entre a Psicanálise e as Neurociências.

  18. Fernand Braudel : Civilisation matérielle, Economie et Capitalisme trente ans après

    OpenAIRE

    Garner, Guillaume

    2013-01-01

    Trente ans après la publication par Fernand Braudel de sa trilogie Civilisation matérielle, Économie et Capitalisme XVe-XVIIIe siècle, l’IFHA (Guillaume Garner) et le Global and European Studies Institute de l’Université de Leipzig (Matthias Middell) se sont associés pour organiser une journée d’études franco-allemande, qui s’est tenue à Leipzig le 2 octobre 2009, dont le but était moins de discuter de la pertinence des conclusions formulées par F. Braudel que d’évaluer, sur le plan des probl...

  19. 返工设备——APR-5000-XLS阵列封装返工系统

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Metcal公司2001年推出阵列封装返工系统,确立了可重复性、精度和温度控制的新标准。该公司最近推出的APR-5000-XLS阵列封装返工系统,再次确立了精确、有成本效益的、最大范围元件类型的返工基准,可处理BGA,CSP,LGA(Land Grid Array),Micro SMD,MLF(Micro-Lead Frame),BCC(Bumped Chip Component)多种封装。

  20. 返工设备——APR-5000-XLS阵列封装返工系统

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    APR-5000-XLS阵列封装返工系统可处理BGA,CSP,LGA(Land Grid Array),Micro SMD,MLF(Micro—Lead Frame),BCC(Bumped Chip Component)多种封装。其可处理的板尺寸达610mm×610mm(24.5″×24.5″),厚度达6.35mm(0.25″)。双程、全空气底部预热,能处理大小不同规格的PCB板。采用5个热电偶输入和闭环RTD温度控制,

  1. O après-coup e a reconsolidação da memória

    OpenAIRE

    Graziele Luiza Barizon Scopel Gerbasi; Paulo José da Costa

    2015-01-01

    Em diferentes áreas do conhecimento é reconhecido que a memória está sujeita a transformações ao longo do tempo. Partindo desse pressuposto, o objetivo do presente estudo é apresentar uma discussão compreendendo a ideia de que nossas recordações são suscetíveis a transformações e a concepção de après-coup. Há o delineamento de algumas ideias acerca da temporalidade em Psicanálise e do mecanismo de reconsolidação da memória segundo as Neurociências. Utilizando-se tais conceitos, evidenciou-se ...

  2. Performance and scenario evaluation of PAFS through the LOFW accident in APR1400 by using MARS code

    International Nuclear Information System (INIS)

    In order to enhance the safety feature of the APR1400 through the passive ways, the passive auxiliary feedwater system(PAFS) is under preliminary consideration by KAERI. For the successful adaptation of PAFS, accident scenario evaluation of PWR plant that is assumed to have the PAFS system should be performed. Condensing heat exchanger assemblies are installed at the exterior boundary of the containment building per one steam generator. The performance of the heat exchanger is designed to remove the decay heat of the fuel completely. In normal operation condition, PAFS system is not connected with the steam and feed lines. A Total Loss of Feed Water(TLOFW) accident is selected for the performance and scenario evaluation after the severity check. The PAFS connection valves are open at the signal of 25% level trip of steam generator. With the single failure assumption of PAFS open valve, the scenario propagations are calculated by using MARS code

  3. Performance and scenario evaluation of PAFS through the LOFW accident in APR1400 by using MARS code

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Sung Won; Bae, Byoung Uhn; Yun, Byong Jo [Korea Atomic Energy Institute, Daejeon (Korea, Republic of)

    2009-07-01

    In order to enhance the safety feature of the APR1400 through the passive ways, the passive auxiliary feedwater system(PAFS) is under preliminary consideration by KAERI. For the successful adaptation of PAFS, accident scenario evaluation of PWR plant that is assumed to have the PAFS system should be performed. Condensing heat exchanger assemblies are installed at the exterior boundary of the containment building per one steam generator. The performance of the heat exchanger is designed to remove the decay heat of the fuel completely. In normal operation condition, PAFS system is not connected with the steam and feed lines. A Total Loss of Feed Water(TLOFW) accident is selected for the performance and scenario evaluation after the severity check. The PAFS connection valves are open at the signal of 25% level trip of steam generator. With the single failure assumption of PAFS open valve, the scenario propagations are calculated by using MARS code.

  4. Conceptual design of passive containment cooling system with air holdup tanks in the concrete containment of improved APR+

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, Byong Guk; NO, Hee Cheon, E-mail: hcno@kaist.ac.kr

    2014-02-15

    Highlights: • Conceptual design of passive containment cooling system (PCCS) based on APR+ is proposed. • Decay heat removal rate is to be maximized by introducing air holdup tanks (AHT). • Only air is transported into the AHT decreasing air mass fraction near HXs inside containment and increasing heat transfer rates. • Large AHT volume gives significantly higher heat removal rate. • External HXs have merits over in-tube HXs for long term cooling. - Abstract: The accident of the Fukushima nuclear power plant emphasized passive systems against prolonged station blackout. This paper aims at conceptual design of passive containment cooling system (PCCS) based on APR+, an advanced PWR developed in Korea with passive auxiliary feedwater system (PAFS). In the design, decay heat removal rate is to be maximized by introducing air holdup tanks (AHT). The AHT is an isolated space disposed above IRWST and is connected to the containment free space by vent lines through IRWST water and PAFS heat exchangers (HXs), where steam generated by decay heat is condensed. Since a lot of steam is condensed through in-tube HXs and IRWST water, air is mainly transported into the AHT decreasing air mass fraction near HXs inside containment and increasing heat transfer rates. Several design options (AHT volume, flow distribution in vent lines, HX types) are evaluated via scoping analysis. The scoping analysis had proved that AHT (>10% containment volume) decreased the required number of PCCS HXs to be installed less than a half, failure of valves caused marginal increase in HXs to be installed, and external HXs had merits over in-tube HXs for long term cooling.

  5. Design of condensation heat exchanger for the PAFS (Passive Auxiliary Feedwater System) of APR+ (Advanced Power Reactor Plus)

    International Nuclear Information System (INIS)

    Highlights: ► Condensation heat exchanger for the PAFS (Passive Auxiliary Feedwater System) was designed. ► The requirement of the heat removal rate and the prevention of water hammer phenomena were considered. ► The proposed design of the heat exchanger satisfied the requirement of the passive heat removal system. - Abstract: The APR+ (Advanced Power Reactor Plus), a next generation nuclear power plant in Korea, has adopted the PAFS (Passive Auxiliary Feedwater System) on the secondary system of the steam generator (SG) as an advanced safety feature. It is intended to replace the conventional auxiliary feedwater system, which consists of active components for the SG in a passive way. It removes decay heat from the reactor core by cooling down the secondary system of the SG using a condensation heat exchanger installed in the PCCT (Passive Condensation Cooling Tank). The objective of this study is to design a condensation heat exchanger for the PAFS and to evaluate the cooling performance for the proposed design using the thermal hydraulic system analysis code, MARS (Multi-dimensional Analysis for Reactor Safety). Requirements such as the heat removal capacity and the prevention of water hammer were preferentially considered to determine the design parameters of the heat exchanger tube. The MARS code analysis result showed that the proposed design of the PAFS heat exchanger is able to cool down the required amount of decay heat. The distribution of a liquid volume fraction and flow regime predicted by the MARS code shows that the proposed design of the heat exchanger excludes the water hammer inside the tube. Estimation of a two-phase flow pressure drop indicates that the pressure drop inside the tube is negligible compared to the total pressure drop in the PAFS. From the MARS code analysis, it is concluded that the proposed design of the condensation heat exchanger in the PAFS satisfies the overall criteria for the performance of the passive heat removal

  6. APR-246 (PRIMA-1(MET)) strongly synergizes with AZD2281 (olaparib) induced PARP inhibition to induce apoptosis in non-small cell lung cancer cell lines.

    Science.gov (United States)

    Deben, Christophe; Lardon, Filip; Wouters, An; Op de Beeck, Ken; Van den Bossche, Jolien; Jacobs, Julie; Van Der Steen, Nele; Peeters, Marc; Rolfo, Christian; Deschoolmeester, Vanessa; Pauwels, Patrick

    2016-06-01

    APR-246 (PRIMA-1(Met)) is able to bind mutant p53 and restore its normal conformation and function. The compound has also been shown to increase intracellular ROS levels. Importantly, the poly-[ADP-ribose] polymerase-1 (PARP-1) enzyme plays an important role in the repair of ROS-induced DNA damage. We hypothesize that by blocking this repair with the PARP-inhibitor AZD2281 (olaparib), DNA damage would accumulate in the cell leading to massive apoptosis. We observed that APR-246 synergistically enhanced the cytotoxic response of olaparib in TP53 mutant non-small cell lung cancer cell lines, resulting in a strong apoptotic response. In the presence of wild type p53 a G2/M cell cycle block was predominantly observed. NOXA expression levels were significantly increased in a TP53 mutant background, and remained unchanged in the wild type cell line. The combined treatment of APR-246 and olaparib induced cell death that was associated with increased ROS production, accumulation of DNA damage and translocation of p53 to the mitochondria. Out data suggest a promising targeted combination strategy in which the response to olaparib is synergistically enhanced by the addition of APR-246, especially in a TP53 mutant background. PMID:26975633

  7. A systematic core design method for reduction of critical boron concentration in APR 1400 with gadolinia-bearing assembly

    International Nuclear Information System (INIS)

    Highlights: • A systematic core design method reduces CBC of APR 1400. • The core design method solves a non-linear programming problem. • The solution is a set of new Gd-bearing fuel assembly design. • LP loading new Gd-bearing fuel assembly designs achieves target CBCs. • Lower L/H ratio shows longer hold-down effect than higher L/H ratio. - Abstract: A systematic core design method is developed to design Gd-bearing fuel assembly having two types of Gd rods, low-wt%-Gd rod and high-wt%-Gd rod. The purpose of the method is to lower the critical boron concentration (CBC) of a preliminary core loading pattern, and consequently to achieve more negative or less positive moderator temperature coefficient (MTC). The proposed core design method is a process of solving a non-linear programming problem stated with a system of equations. In this method, both the ratio of the number of low-wt%-Gd rod to the number of high-wt%-Gd rod (r) and the assembly average Gd wt% (w) are the solution variables of the system of equations. The target function is the amount of soluble boron concentration reduction, ΔCBC, which is correlated with the reactivity change, ΔkFA, per Gd-bearing fuel assembly by a quadratic reactivity equation. The coefficients of the quadratic equations are calculated prior to the determination of Gd-bearing fuel assembly pattern, using the least square method. The constraints required to determine (r, w) are physically realizable Gd rods pattern, Δki close to ΔkFA derived from ΔCBC, etc. An objective function, min[f(∑i(ΔkFA-Δki))], enables a final loading pattern to reach a target CBC. This design methodology is applied to APR 1400. Total six cases with various target CBCs are investigated to validate the proposed method. CASMO-3/MASTER calculations with new design assemblies produce lower CBCs at BOC than target CBCs keeping maximum pin power below the safety limit, and thus show more negative MTC

  8. War Medicine and Surgery, Punishment and Torture at the time of the Regiments of Renown - Chirurgie de guerre, médecine militaire, punitions et torture à l’époque des compagnies de mercenaires - Medicina e Chirurgia da guerra, Punizioni e Tortura all’epoca delle Compagnie di Ventura

    Directory of Open Access Journals (Sweden)

    Lugaresi M.

    2009-08-01

    Full Text Available This article highlights the main surgical and medical issues related to the age of the Regiments of Renown. Analyzing the main causes of death of Condottieres and Captains in the period 1300-1580, the treatment of wounds and the development of skills involved in the surgery of war, the more frequent Italian epidemic diseases in that time, the punishments and torture in force in the Republic of Venice, are described.Cet article expose les aspects les plus importants en matière de médecine et de chirurgie à l'époque des compagnies de mercenaires. En analysant les principales causes de décès des condottières et des capitaines entre 1300 et 1580, l’autrice décrit le traitement des blessures et le développement des techniques chirurgicales de guerre, les épidémies les plus fréquentes en Italie à cette époque-là, les peines et les tortures en vigueur sous la République Sérénissime de Venise.Questo articolo illustra i principali aspetti medici e chirurgici connessi all’epoca delle Compagnie di Ventura. Analizzando le principali cause di decesso dei Condottieri e dei Capitani nel periodo 1300-1580, vengono descritte la cura delle ferite e lo sviluppo delle tecniche applicate nella chirurgia da guerra, le epidemie più frequenti che colpirono l’Italia in tale epoca, le pene e la tortura in vigore nella Serenissima Repubblica di Venezia.

  9. APR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations.

    Science.gov (United States)

    Shen, Jinfeng; van den Bogaard, Ellen H; Kouwenhoven, Evelyn N; Bykov, Vladimir J N; Rinne, Tuula; Zhang, Qiang; Tjabringa, Geuranne S; Gilissen, Christian; van Heeringen, Simon J; Schalkwijk, Joost; van Bokhoven, Hans; Wiman, Klas G; Zhou, Huiqing

    2013-02-01

    p53 and p63 share extensive sequence and structure homology. p53 is frequently mutated in cancer, whereas mutations in p63 cause developmental disorders manifested in ectodermal dysplasia, limb defects, and orofacial clefting. We have established primary adult skin keratinocytes from ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) syndrome patients with p63 mutations as an in vitro human model to study the disease mechanism in the skin of EEC patients. We show that these patient keratinocytes cultured either in submerged 2D cultures or in 3D skin equivalents have impaired epidermal differentiation and stratification. Treatment of these patient keratinocytes with the mutant p53-targeting compound APR-246/PRIMA-1(MET) (p53 reactivation and induction of massive apoptosis) that has been successfully tested in a phase I/II clinical trial in cancer patients partially but consistently rescued morphological features and gene expression during epidermal stratification in both 2D and 3D models. This rescue coincides with restoration of p63 target-gene expression. Our data show that EEC patient keratinocytes with p63 mutations can be used for characterization of the abnormal molecular circuitry in patient skin and may open possibilities for the design of novel pharmacological treatment strategies for patients with mutant p63-associated developmental abnormalities. PMID:23355676

  10. A study on issues and solutions about logic functions applied to computerized procedure system in APR1400

    International Nuclear Information System (INIS)

    Plant procedures are instructions to guide operators in monitoring, decision making, and controlling nuclear power plants(NPPs). While plant procedures historically have been paper-based, computerized-based procedures are being developed to overcome the drawbacks of paper-based procedures. The CPS is used to integrate the operational instructions, plan process information and computerized operator support functions in advanced main control room (MCR) of APR1400. The logic functions applied to CPS are three categories: Procedure Entry Condition (PEC), Continuously Applied Step (CAS) re-execution condition, instruction evaluation. This automation using logic function can reduce operator 2019's burden about monitoring, decision making, controlling NPPs but this automation can also lower situation awareness and operator in the loop. These automation issues caused by logic function shall be closed to apply computerized procedure. This paper introduces issues drawn by system designer, plant operators, and human factors engineers. To close these introduced issues, this paper suggests solutions from system design, procedure writer's guideline, and operator training. This paper introduces issues drawn by system designer, plant operators, and human factors engineers. To close these introduced issues, this paper suggests solutions from system design, procedure writer's guideline, and operator training

  11. The fifteenth period report on the cooperative utilization of the AVF cyclotron at Osaka University RCNP (Dec 1982 - Apr 1983)

    International Nuclear Information System (INIS)

    The AVF cyclotron at the RCNP (Research Center for Nuclear Physics) of Osaka University has been cooperatively used by various researchers of Japanese universities or colleges. This collective report covers papers concerning various studies performed at the AVF during Dec 1982 to Apr 1983. Some of the titles of these papers are as follows : Elastic scattering of 56 MeV polarized deuterons from 12C and 40Ca ; Pionic three-nucleon capture reactions ; Measurement on branching ratios of short-lived beta emitter 23Mg and its hyperfine interactions ; Half-life and branching ratios of short-lived beta emitter 13O ; 7Li excitation of the giant resonances in 208Pb ; Measurements of spin polarization of residual nuclei after light particle emission in heavy ion reactions ; Target dependence of the sequential alpha decay through the narrow resonances of 20Ne ; Analyzing power of neutron continuum spectra for the 93Nb (p,nx) reaction and a simple one step OWBA analysis ; Energy dependence of the reaction mechanism for the 3He and alpha induced reactions ; Medium energy gamma rays following radiative capture of polarized protons on light nuclei. (Aoki, K.)

  12. A condensation heat transfer model for nearly horizontal tubes of the Passive Auxiliary Feedwater System in APR+

    International Nuclear Information System (INIS)

    A new condensation heat transfer model based on the flow regime in the nearly horizontal tube has been developed for the Passive Auxiliary Feed-water System (PAFS) of Korean Advanced Power Reactor Plus (APR+). This study focused on the stratified flow in horizontal tubes in which two different heat transfer mechanisms are involved. The void fraction was determined from the 1-D separated flow model (SFM) which incorporates closure relations for shear stress defined by single-phase based expressions and geometric relations for a concave interface using the eccentric circles. The wetted angle proposed by Hart's correlation (1989) was used to classify flow regimes into annular, stratified-wavy and stratified-smooth flow. The new film condensation heat transfer correlation based on Nusselt's integral analysis (1916) was proposed to predict the heat transfer coefficient affected by the vapor flow on the upper portion of tube in the stratified flow. Furthermore, the convective heat transfer correlation for single-phase heat transfer was used to predict the heat transfer coefficient for condensate flowing on the entire perimeter of annular flow and the bottom of the stratified flow. Both heat transfer correlations use Reynolds number based on the phasic actual velocities and geometric variables obtained from SFM. Finally, the new condensation heat transfer model package was evaluated against available experimental data for water and it showed good results. (author)

  13. General arrangement design optimization of emergency response facility (TSC, OSC) in Korea next generation reactor (APR-1400)

    International Nuclear Information System (INIS)

    The accident at the Three Mile Island (TMI) led to install some data processing and display equipment to assist control room personnel in rapidly evaluating the safety status. And also to place in the plant for providing operators with technical support and an emergency response center for radiological environmental assessments and determination of recommended public protective action during emergency. In practice, most of the countries possessing nuclear power plants including USA have partially or wholly adopted US NRC regulations and guidelines for Emergency Response Facility(ERF). Also the Korea nuclear power plants are implementing or operating ERF and SPDS after analyzing US NRC regulations and guideline since TMI accident. So this paper first been reviewed Korea Regulations, US NRC published codes and standards related to ERF (TSC/OSC). Finally this paper is described the design optimization of general arrangement in emergency response facility to improve emergency response capability in Korea Next Generation Reactor(APR-1400), which are best suitable for our domestic situation and also enhance the emergency response capability of ERF

  14. Discussion on RELAP5 and RETRAN3D Modeling for Passive Condensate Cooling Tank of Passive Auxiliary Feedwater System in APR+

    International Nuclear Information System (INIS)

    Domestic nuclear industry has started the development of APR+ as a Korean specific reactor for the export strategy. In the development of APR+ a passive auxiliary feedwater system (PAFS) has been considered as a noticeable candidate of improved design. The outline of PAFS and passive condensate cooling tank (PCCT) containing horizontal heat exchanger is shown in Fig. 1. For the successful design of PAFS, performance analyses or safety analyses are prerequisite using best estimate thermal hydraulic codes such as RELAP5 or RETRAN3D. Because of the inherent features of RELAP5 or RETRAN3D, pool model and condensation in horizontal tube have not been well-setup nor widely studied. This paper discusses about the PCCT phenomena including steam condensation in horizontal tube and pool heat transfer, and RELAP5 and RETRAN3D modeling

  15. Facteurs influençant le retour au travail après transplantation chez 61 patients rénaux ou hépatiques

    OpenAIRE

    Praz-Christianaz S.-M.

    2014-01-01

    Enjeux La réussite d'une transplantation rénale ou hépatique intègre non seulement le succès de l'acte chirurgical et sa prise en charge médicale post-greffe, mais également pour le patient greffé l'assurance d'une nouvelle qualité de vie dont le retour au travail fait partie. Le retour au travail après greffe est cependant généralement peu étudié dans la littérature et peu discuté semble-t-il au niveau médical que ce soit avant ou après greffe, quand bien même d'un point de vue médico-socio-...

  16. Une première consultation après la crise de décembre 2007Les élections partielles du 11 juin 2008

    OpenAIRE

    Cussac, Anne

    2008-01-01

    Après les élections générales du 27 décembre 2007, les Kenyans, dans certaines circonscriptions électorales ont denouveau été appelés aux urnes le 11 juin 2008, pour élire cinq députés et une cinquantaine de représentantslocaux. Ces élections partielles, qui se déroulées dans les circonscriptions d’Ainamoi, Emuhaya, Embakasi1, Kilgoris etWajir North, ont constitué la toute première consultation après la formation du gouvernement de grande coalition entrele Party of National Unity (PNU) du Pré...

  17. Mu dX, a derivative of Mu d1 (lac Apr) which makes stable lacZ fusions at high temperature.

    OpenAIRE

    Baker, T A; Howe, M M; Gross, C A

    1983-01-01

    We describe defective Mu phage Mu dX (Mu d1 Bx::Tn9 [lac Apr Cmr]) which is useful for insertion mutagenesis and for construction of lac operon fusions in vivo. Mu dX retains the insertion properties of Mu d1 but produces temperature-resistant lysogens and transposes at a reduced frequency. A method is described to convert existing Mu d1 insertions to Mu dX.

  18. Antiviral activity of the plant extracts from Thuja orientalis, Aster spathulifolius, and Pinus thunbergii against influenza virus A/PR/8/34.

    Science.gov (United States)

    Won, Ji-Na; Lee, Seo-Yong; Song, Dae-sub; Poo, Haryoung

    2013-01-01

    Influenza viruses cause significant morbidity and mortality in humans through epidemics or pandemics. Currently, two classes of anti-influenza virus drugs, M2 ion-channel inhibitors (amantadin and rimantadine) and neuraminidase inhibitors (oseltamivir and zanamivir), have been used for the treatment of the influenza virus infection. Since the resistance to these drugs has been reported, the development of a new antiviral agent is necessary. In this study, we examined the antiviral efficacy of the plant extracts against the influenza A/PR/8/34 infection. In vitro, the antiviral activities of the plant extracts were investigated using the cell-based screening. Three plant extracts, Thuja orientalis, Aster spathulifolius, and Pinus thunbergii, were shown to induce a high cell viability rate after the infection with the influenza A/PR/8/34 virus. The antiviral activity of the plant extracts also increased as a function of the concentration of the extracts and these extracts significantly reduced the visible cytopathic effect caused by virus infections. Furthermore, the treatment with T. orientalis was shown to have a stronger inhibitory effect than that with A. spathulifolius or P. thunbergii. These results may suggest that T. orientalis has anti-influenza A/PR/8/34 activity. PMID:23314378

  19. Development of a Phenomena Identification Ranking Table (PIRT) for a Station Black Out (SBO) Accident of the APR1400

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Kyoung Ho; Yun, Byong Jo; Sim, Suk Ku and others

    2013-10-15

    SBO is one of the most important DEC in that without any proper operator actions, a total loss of heat sink leads to core uncover, to core damage, and ultimately a core melt-down scenario under high pressure. Due to this safety importance, SBO is considered to be a base test item of the OECD-ATLAS project. In this study, Phenomena Identification Ranking Table (PIRT) has been developed for identifying the major parameters affecting the thermal-hydraulic phenomena in SBO transients. Development of PIRT for SBO transient is expected to contribute to making strategy for performing a thermal-hydraulic integral effect test with ATLAS which includes determination of proper test conditions and improvement of measurements. The PIRT process used in this study follows the methodology previously applied in the Passive Auxiliary Feedwater System (PAFS) of the APR+ (Advanced Power Reactor Plus). The PIRT has been developed for identifying the major parameters affecting the thermal-hydraulic phenomena during a SBO transient. The PSC was determined to be the core mixture level from the expert panel discussion. As for the major components of the nuclear power plant, the rank of the importance and the knowledge level were summarized for each of the three temporal phases. Taking into account the important phenomena from the PIRT result, it can be confirmed that ATLAS has a capability of simulating the major thermal-hydraulic phenomena during a SBO transient as realistically as possible. The present PIRT is expected to contribute to making strategy for performing a thermal-hydraulic integral effect test with ATLAS in the framework of the OECD-ATLAS project.

  20. Texture et Anisotropie du comportement mécanique après laminage à chaud d'un alliage léger Aluminium Cuivre Lithium (2050) pour l'aéronautique

    OpenAIRE

    Contrepois, Quentin

    2010-01-01

    Ce travail vise à comprendre l’évolution de la texture cristallographique et l’anisotropie du comportement mécanique après laminage à chaud et traitements thermiques d’un Al-Cu-Li 2050 et d’un Al-Zn-Mg-Cu 7050, et expliquer leurs différences. La texture est analysée par EBSD et RX après des essais de compression plane à chaud et après des laminages à chaud industriels. L’anisotropie est étudiée sur des tôles fortes industrielles après différents détensionnements et dans différents états micro...

  1. PRIMA-1Met/APR-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53

    DEFF Research Database (Denmark)

    Zandi, Roza; Selivanova, Galina; Christensen, Camilla Laulund;

    2011-01-01

    Small cell lung cancer (SCLC) is a highly malignant disease with poor prognosis, necessitating the need to develop new and efficient treatment modalities. PRIMA-1(Met) (p53-dependent reactivation of massive apoptosis), also known as APR-246, is a small molecule, which restores tumor suppressor...... function to mutant p53 and induces cancer cell death in various cancer types. Since p53 is mutated in more than 90% of SCLC, we investigated the ability of PRIMA-1(Met) to induce apoptosis and inhibit tumor growth in SCLC with different p53 mutations....

  2. Peut-on réaliser une analgésie péridurale après un blood patch récent?

    Science.gov (United States)

    Chkoura, Khalid; Kechna, Hicham; Loutid, Jaouad; Ouzad, Omar; Hachimi, Moulay Ahmed; Hannafi, Sidi Mohamed

    2015-01-01

    Le blood patch constitue le traitement de référence du syndrome post ponction lombaire. Son efficacité a été démontrée par plusieurs essais randomisés comparant le BPE aux mesures conservatrices et au placebo. Il consiste en l'injection d'une quantité de sang autologue dans l'espace péridurale afin d'obturer la brèche dure-mérienne. La réalisation d'une analgésie péridurale après antécédent de blood patch est possible, malgré la persistance de questions sur les délais de retour à la normal de l'espace péridurale. Nous rapportons un cas où une analgésie péridurale a été réalisée avec succès trois semaines après un blood patch. PMID:26600909

  3. Recovery and radio-resistance in mice after external irradiation; Restauration et radio-resistance chez la souris apres irradiation externe

    Energy Technology Data Exchange (ETDEWEB)

    Le Guillou, S. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1965-07-01

    The author presents a literature study concerning recovery from external irradiation and an analysis of experimental data (which appear to suggest the idea of a radio-resistance in animals), as well as the hypotheses put forward for explaining this phenomenon. The author then describes an experiment carried out on mice whose LD 50/30 days increased from 1005 to 1380 rads and for which it was shown that an increase occurs in the number of certain anti-bodies circulating after a low dose of {gamma} irradiation. (author) [French] L'auteur presente une etude bibliographique de la restauration apres irradiation externe et une analyse des donnees experimentales qui paraissent suggerer la notion de radioresistance chez les animaux ainsi que les hypotheses cherchant a expliquer ce phenomene. Il relate ensuite une experience realisee sur des souris dont la DL 50/30 jours est passee de 1005 a 1380 rads et dans laquelle est montree l'augmentation de certains anticorps circulant apres une faible dose d'irradiation gamma. (auteur)

  4. Photodiagnostic et chirurgie guidés par la fluorescence

    OpenAIRE

    Mordon, Serge; Bourg-Heckly, Geneviève

    2015-01-01

    Pour de nombreux cancers, plus le diagnostic est réalisé précocement, moins les traitements sont lourds et meilleures sont les chances de guérison. L'utilisation de méthodes optiques de diagnostic précoce, basées sur des mesures de fluorescence (photodiagnostic) repose soit sur une fluorescence naturelle, soit sur la répartition d'un marqueur fluorescent permettant de distinguer le tissu tumoral du tissu sain. En cancérologie, l'ablation chirurgicale complète de la tumeur est un des facteurs ...

  5. Erhalt der Arteria rectalis superior in der Divertikulitis-Chirurgie

    OpenAIRE

    Schachtebeck, Michael

    2016-01-01

    Background: Preservation of the superior rectal artery (SRA) in sigmoid resection continues to be a matter of debate. The practical relevance of preserving the SRA has not been thoroughly investigated and randomized controlled trials are largely missing. In tubular sigmoid resection the SRA is preserved. The artery can be preserved in anterior resection, too. Vascular supply to bowel anastomosis has been determined as an important factor for postoperative healing. This thesis investigates the...

  6. Bypassmaterialien in der Gefäßchirurgie

    OpenAIRE

    Eidt, D; Roll, S.; Kulp, W; Müller-Nordhorn, J.; Vauth, C; Greiner, W; Willich, SN; von der Schulenburg, JM

    2006-01-01

    Introduction Arteriosclerotic changes can lead to circulatory disturbances in various areas of the human vascular system. In addition to pharmacological therapy and the management of risk factors (e. g. hypertension, diabetes, lipid metabolism disorders, and lifestyle), surgical interventions also play an important role in the treatment of arteriosclerosis. Long-segment arterial occlusions, in particular, can be treated successfully with bypass sur-gery. A number of different materials are av...

  7. Die plastisch-rekonstruktive Chirurgie aus Sicht der Kinderchirurgie

    Directory of Open Access Journals (Sweden)

    Finke, Rainer

    2013-02-01

    Full Text Available Plastic reconstructive surgery from a pediatric surgical point of view means more than to apply adult surgical techniques and methods to pediatric conditions. A child’s multidimensional characteristics and particularity, development potential, wishes and expectations must be respected during planning and conduction of surgical procedures. In this article the relevance of the four pillars of plastic surgery for the different phases of childhood are portrayed. Especially the legal and ethnic problems of treatment modalities of disorders of sex differentiation are discussed, particularly taking into consideration the heterogeneity of this entity. We see no indication for gender assigning operations during childhood since an informed consent cannot be obtained due to the age of the patient. A cosmetic and only gender emphasizing operation for a child with congenital adrenal hyperplasia may only be performed in concordance with the guidelines of the German Ethics Council and after extensive and independent consultation.

  8. L'hypnose et son application en chirurgie.

    OpenAIRE

    Faymonville, Marie; Defechereux, Thierry; Joris, Jean; Adant, J. P.; Hamoir, Etienne; Meurisse, Michel

    1998-01-01

    Since 1992, we have used hypnosis routinely in more than 1400 patients undergoing surgery. We found that hypnosis used in patients as an adjunct to conscious sedation and local anesthesia was associated with improved intraoperative patient comfort, and with reduced anxiety, pain, intraoperative requirements for anxiolytic and analgesic drugs, optimal surgical conditions and a faster recovery of the patient. We reported our clinical experience and our fundamental research. Peer reviewed

  9. Die plastisch-rekonstruktive Chirurgie aus Sicht der Kinderchirurgie

    OpenAIRE

    Finke, R

    2013-01-01

    Plastic reconstructive surgery from a pediatric surgical point of view means more than to apply adult surgical techniques and methods to pediatric conditions. A child's multidimensional characteristics and particularity, development potential, wishes and expectations must be respected during planning and conduction of surgical procedures. In this article the relevance of the four pillars of plastic surgery for the different phases of childhood are portrayed. Especially the legal and ethnic pr...

  10. Die plastisch-rekonstruktive Chirurgie aus Sicht der Kinderchirurgie

    OpenAIRE

    Finke, Rainer

    2013-01-01

    Plastic reconstructive surgery from a pediatric surgical point of view means more than to apply adult surgical techniques and methods to pediatric conditions. A child’s multidimensional characteristics and particularity, development potential, wishes and expectations must be respected during planning and conduction of surgical procedures. In this article the relevance of the four pillars of plastic surgery for the different phases of childhood are portrayed. Especially the legal and ethnic pr...

  11. Wassergefiltertes Infrarot A in Chirurgie, Dermatologie, Sportmedizin und weiteren Bereichen

    OpenAIRE

    Hoffmann, Gerd

    2012-01-01

    Wassergefiltertes Infrarot A (wIRA) stellt eine spezielle Form der Infrarotstrahlung (Wärmestrahlung) im Bereich von 780–1400 nm dar, die aufgrund ihrer sehr guten Verträglichkeit in der Medizin zur Prävention und Therapie verwendet wird. wIRA entspricht dem Großteil der in gemäßigten Klimazonen die Erdoberfläche wassergefiltert erreichenden Infrarotstrahlung der Sonne (Filterwirkung des Wassers und des Wasserdampfs der Erdatmosphäre). Durch die Wasserfilterung werden die Strahlungsanteile ge...

  12. Plastische chirurgie bij patiënten met een aangezichtsverlamming

    NARCIS (Netherlands)

    Werker, P M N

    2007-01-01

    In short-term irreversible paralysis caused by facial nerve problems the aim is to re-innervate the paralysed facial musculature. Whenever a paralysis remains untreated for longer than 12-18 months successful re-innervation is unlikely. In longer-term paralysis the symmetry of the face at rest can b

  13. Truman, "faith-based" diplomatie et ambigüités du Plan Marshall : cas de la France de l'après-guerre

    OpenAIRE

    Autran, Jean-Marie

    2015-01-01

    La "Faith-based" diplomatie américaine et les ambiguïtés du plan Marshall : le cas de la France dans l’après-guerre. Le Président Harry S. Truman (1945-1953) affirme dès 1946 que les E.U. doivent s’armer d'une « diplomatie fondée sur la foi » pour encourager la reconstruction spirituelle d'une Europe « déchristianisée » face au communisme. Pour faire barrage au marxisme de l’Union Soviétique, il fallait commencer par la France, vue comme la pierre de voûte spirituelle. Plus que toute autre na...

  14. Development of a Prototypical Condensation Model for the Nearly Horizontal Heat Exchanger Tube of the APR+ PAFS(Passive Auxiliary Feed-water System)

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Tae Hwan; Yun, Byong Jo; Jeong, Jae Jun [Pusan National Univ., Busan (Korea, Republic of)

    2013-10-15

    In this study, a new condensation heat transfer model was developed for the separated flow regime in the nearly horizontal tube. A new heat transfer model which takes into account of different heat transfer mechanisms occurred in the upper and lower regions of perimeters was developed in the nearly horizontal tube. The present model shows good prediction capability against experimental data. Passive Auxiliary Feed-water System(PAFS) which is adopted in the Korean advanced nuclear power plant, APR+, removes decay heat by condensing steam from the secondary side in the nearly horizontal tubes under the accident condition. The comparison of prediction against PASCAL(2011) experimental data obtained by KAERI indicated that the best estimated safety analysis code such as MARS tends to underestimate the condensation heat transfer coefficient.

  15. Development of a Prototypical Condensation Model for the Nearly Horizontal Heat Exchanger Tube of the APR+ PAFS(Passive Auxiliary Feed-water System)

    International Nuclear Information System (INIS)

    In this study, a new condensation heat transfer model was developed for the separated flow regime in the nearly horizontal tube. A new heat transfer model which takes into account of different heat transfer mechanisms occurred in the upper and lower regions of perimeters was developed in the nearly horizontal tube. The present model shows good prediction capability against experimental data. Passive Auxiliary Feed-water System(PAFS) which is adopted in the Korean advanced nuclear power plant, APR+, removes decay heat by condensing steam from the secondary side in the nearly horizontal tubes under the accident condition. The comparison of prediction against PASCAL(2011) experimental data obtained by KAERI indicated that the best estimated safety analysis code such as MARS tends to underestimate the condensation heat transfer coefficient

  16. La présence des Nabatéens en Italie (ier siècle av.-iie siècle apr. J.-C.)

    OpenAIRE

    Schwentzel, Christian-Georges

    2015-01-01

    La présence des Nabatéens en Italie est attestée par plusieurs documents épigraphiques ainsi que par quelques monuments découverts à Pouzzoles : des autels et des objets de culte, des sculptures. Cette présence s’est sans doute développée à la fin du iie s. av. J.-C., ou au début du ier siècle av. J.-C., avant de s’effacer, probablement au iie siècle apr. J.-C. En tout cas, les documents épigraphiques mentionnant la présence de Nabatéens en Italie sont datés des règnes de Malichos Ier (58-30 ...

  17. The LasB Elastase of Pseudomonas aeruginosa Acts in Concert with Alkaline Protease AprA To Prevent Flagellin-Mediated Immune Recognition.

    Science.gov (United States)

    Casilag, Fiordiligie; Lorenz, Anne; Krueger, Jonas; Klawonn, Frank; Weiss, Siegfried; Häussler, Susanne

    2016-01-01

    The opportunistic pathogen Pseudomonas aeruginosa is capable of establishing severe and persistent infections in various eukaryotic hosts. It encodes a wide array of virulence factors and employs several strategies to evade immune detection. In the present study, we screened the Harvard Medical School transposon mutant library of P. aeruginosa PA14 for bacterial factors that modulate interleukin-8 responses in A549 human airway epithelial cells. We found that in addition to the previously identified alkaline protease AprA, the elastase LasB is capable of degrading exogenous flagellin under calcium-replete conditions and prevents flagellin-mediated immune recognition. Our results indicate that the production of two proteases with anti-flagellin activity provides a failsafe mechanism for P. aeruginosa to ensure the maintenance of protease-dependent immune-modulating functions. PMID:26502908

  18. Modele de simulation de la duree d'humectation des feuilles au champ apres une pluie. Cas d'un couvert homogene

    OpenAIRE

    Huber, L.

    1988-01-01

    La présence d’eau libre à la surface des organes végétaux pendant un temps minimal est un facteur essentiel lors de la contamination de la plante-hôte par un champignon. Afin de prévoir l’occurrence de ce phénomène en terme de durée, un modèle multi-couches de transfert de masse et d’énergie est adapté au cas de la simulation de la durée d’humectation des feuilles après une pluie au sein d’un couvert végétal homogène. Le but est de spatialiser ce paramètre intéressant les phytopathologis...

  19. Facteurs prédictifs d'une intolérance au glucose après un diabète gestationnel

    OpenAIRE

    Guillermin-Spahr, Marie-Luce

    2004-01-01

    Les critères permettant de prédire la persistance d'une IG après un diabète gestationnel sont insuffisants. Nous avons analysé les caractéristiques ante- et post partum (PP) de 239 femmes avec diabète gestationnel. Les résultats de l'hyperglycémie provoquée (HGPO) 6 semaines post partum étaient: 51% normal; 15% IG; 11% diabète vrai; et 23% IG non diagnostique. Des 42 femmes diagnostiquées précocement (< 24ème semaine), 23% avaient un test normal, et 40% avaient un diabète persistant. Les fact...

  20. Facteurs prédictifs d'une intolérance au glucose après un diabète gestationnel

    OpenAIRE

    Guillermin-Spahr, Marie-Luce; Golay, Alain

    2005-01-01

    Les critères permettant de prédire la persistance d'une IG après un diabète gestationnel sont insuffisants. Nous avons analysé les caractéristiques ante- et post partum (PP) de 239 femmes avec diabète gestationnel. Les résultats de l'hyperglycémie provoquée (HGPO) 6 semaines post partum étaient: 51% normal; 15% IG; 11% diabète vrai; et 23% IG non diagnostique. Des 42 femmes diagnostiquées précocement (< 24ème semaine), 23% avaient un test normal, et 40% avaient un diabète persistant. Les fact...

  1. Best Estimate Thermal-Hydraulic System Analysis using the MARS Code for the Steam Generator Tube Rupture Accident in the APR1400

    International Nuclear Information System (INIS)

    A postulated SGTR (Steam Generator Tube Rupture) accident of the APR1400 was analysed using the best estimate safety analysis code, MARS (Multidimensional Analysis of Reactor Safety). The SGTR accident is one of the design basis accidents, which has a unique feature of the penetration of the barrier between the reactor coolant system (RCS) and the secondary system resulting from the failure of a steam generator U-tube. The SGTR has an importance in safety due to a concern of a containment bypass of radioactive inventory. In the course of the SGTR, the radioactivity leaking from a broken steam generator Utube mixes with the shell-side water in an affected steam generator. Leak flow from ruptured U-tubes can increase a water level and a pressure of the affected steam generator. Following a reactor trip and a turbine trip, the main steam safety valves (MSSVs) can be open to mitigate an increase in the secondary system pressure. Meanwhile, the SGTR can provide a direct flow path from the primary to the secondary system resulting in the release of fission products into the atmosphere. As one of the most limiting SGTR accidents, a leak flow equivalent to a double-ended rupture of five Utubes was analysed in this study. The main objective of this study is not only to provide physical insight into the system response of the APR1400 reactor during a SGTR but also to investigate the effect of reactor trip type of the HSGL (High Steam Generator Level) trip and the LPP (Low Pressurizer Pressure) trip on the thermal-hydraulic system response

  2. Precificação de consultoria empresarial com a contribuição das estratégias de apreçamento = Entrepreneurial Counseling Pricing with Pricing Strategy Contribution

    Directory of Open Access Journals (Sweden)

    Nivaldo João dos Santos

    2008-11-01

    Full Text Available A precificação de serviços de consultoria também pode se beneficiar dos conceitos e idéias das estratégias de apreçamento de bens de consumo de massa, especificamente na área de consultoria de gestão empresarial. Apesar deste campo ser dominado por grandes corporações multinacionais, ainda existe espaço para empresas e profissionais nacionais. Por se tratar de mercado que envolve valores de grande magnitude, imaginasse que as instituições de sucesso adotem estratégia de apreçamento. Neste trabalho, estratégias de apreçamento foram selecionadas para exame e verificação de aplicabilidade quando do estabelecimento valor pelos serviços da consultoria de gestão empresarial. O apreçamento de desnatação, apreçamento de penetração, apreçamento neutro e apreçamento baseado em valor tiveram seus conceitos sintetizados para fins de verificação. O apreçamento baseado em valor se revelou o mais propício para este tipo de produto (consultoria e o processo de comunicação é o elemento crítico para evidenciar valor, benefícios e, finalmente, justificar o preço do serviço. A sugestão de roteiro para apreçamento de serviço de consultoria empresarial é apresentada ao final, como resultado da análise das diversas estratégias de apreçamento.The pricing of counseling services may also benefit from strategy concepts and ideas ofmass consumption goods pricing, specifically within the entrepreneurial managementcounseling area. Even though this field has been taken over by big multinationalcorporations, there is still some space for national enterprisings and professionals. As itis a market that involves values of great magnitude, it is thought that successfulinstitutions adopt this pricing strategy. In this study, pricing strategies were selectedfor analysis and applicability checking by the time the price for entrepreneurialmanagement counseling service was established. The skimming pricing, penetratingpricing, neutral

  3. A Study on Scenario Selection for Evaluation of Fission Product Behavior during a Severe Accident at APR 1400 Nuclear Power Plants

    International Nuclear Information System (INIS)

    As a part of an 'Evaluation of the State-of-the-Art on the Fission Product Behavior and Improvement of the Iodine Evaluation Model' Project, we at KINS plan to investigate source term behavior during a severe accident by MELCOR and to eventually compare it with results by RAIM which is an add-on code to MELCOR including iodine behavior model developed by KINS. Since species and amount of fission products in the containment depend on a specific accident, it is necessary to select accident scenarios for the study, especially taking account of its relative importance of occurrence or resultant effects for a specific plant. In this regard, we have reviewed U.S.NRC's Stateof- the-Art Reactor Consequence Analyses (SOARCA) and applied the SOARCA's method of scenario selection to Probabilistic Safety Assessment (PSA) for Shin-Kori 3·4 nuclear power plants which are APR1400 type reactors. Furthermore, we have selected scenarios from the PSA results with a new criterion in the light of risk, which consists of probability and consequence of accidents of interest. In this study, we have selected scenarios for evaluation of fission product behavior during a severe accident. Applying the U.S.NRC's SOARCA method to Shin-Kori 3·4 PSA revealed that it is practically useful to set a relative criterion for scenario studies since making a definite criterion as in SOARCA requires to consider many spatiotemporal factors such as regulation policies and safety technologies. With this in mind, the relative criterion of the scenario selection has been created using release frequency and release fraction of source term in the respect of risk from APR 1400 type Shin-Kori 3·4 Level 2 PSA. The selected representing scenarios are ISLOCA, SGTR, and SBO. A preliminary analysis has been tried for a SBO sequence with more severe and simple assumptions using MELCOR. The results show early release of volatile elements in the containment

  4. A Study on Scenario Selection for Evaluation of Fission Product Behavior during a Severe Accident at APR 1400 Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, E. S.; Kim, Han-Chul [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of); Cho, Song-Won [NSETec, Daejeon (Korea, Republic of)

    2015-05-15

    As a part of an 'Evaluation of the State-of-the-Art on the Fission Product Behavior and Improvement of the Iodine Evaluation Model' Project, we at KINS plan to investigate source term behavior during a severe accident by MELCOR and to eventually compare it with results by RAIM which is an add-on code to MELCOR including iodine behavior model developed by KINS. Since species and amount of fission products in the containment depend on a specific accident, it is necessary to select accident scenarios for the study, especially taking account of its relative importance of occurrence or resultant effects for a specific plant. In this regard, we have reviewed U.S.NRC's Stateof- the-Art Reactor Consequence Analyses (SOARCA) and applied the SOARCA's method of scenario selection to Probabilistic Safety Assessment (PSA) for Shin-Kori 3·4 nuclear power plants which are APR1400 type reactors. Furthermore, we have selected scenarios from the PSA results with a new criterion in the light of risk, which consists of probability and consequence of accidents of interest. In this study, we have selected scenarios for evaluation of fission product behavior during a severe accident. Applying the U.S.NRC's SOARCA method to Shin-Kori 3·4 PSA revealed that it is practically useful to set a relative criterion for scenario studies since making a definite criterion as in SOARCA requires to consider many spatiotemporal factors such as regulation policies and safety technologies. With this in mind, the relative criterion of the scenario selection has been created using release frequency and release fraction of source term in the respect of risk from APR 1400 type Shin-Kori 3·4 Level 2 PSA. The selected representing scenarios are ISLOCA, SGTR, and SBO. A preliminary analysis has been tried for a SBO sequence with more severe and simple assumptions using MELCOR. The results show early release of volatile elements in the containment.

  5. Analysis of PAFS (Passive Auxiliary Feedwater System) horizontal heat exchanger in APR+ and the scale-up capability of experimental loop

    International Nuclear Information System (INIS)

    APR+ (Advanced Power Reactor Plus) is the next generation nuclear power plant in Korea. It adopts PAFS (Passive Auxiliary Feedwater System) on the secondary system. It can replace the conventional active system for auxiliary feedwater injection to the steam generator, and it enables the coolant to be supplied by a passive system. It cools down the secondary system by heat transfer at a horizontal U-tube in PCCT (Passive Condensation Cooling Tank). High pressure steam flow from the steam generator is condensed in the horizontal heat exchanger. The water in PCCT is maintained at an atmospheric pressure, so that boiling heat transfer at the outside wall of heat exchanger and natural convection occur in PCCT pool. The heat exchanger and PCCT is higher than the steam generator, so condensate can be drained and injected to feedwater system without any active system. This study aims at analyzing the heat removal capacity for the design of the horizontal heat exchanger in PAFS. To design the condensation heat exchanger in PAFS, and the two-phase flow phenomena in horizontal U-tube and were investigated by MARS (Multi-dimensional Analysis for Reactor Safety, a thermal hydraulic system analysis code) calculation. By benchmarking with NOKO experimental result, MARS code showed a reasonable capability to quantitatively predict the condensation in horizontal tube heat exchanger. For the design of PAFS heat exchanger in APR+, the calculation results proved to sufficiently remove the decay heat of 138 MW in total by the condensation heat transfer without any active auxiliary feedwater system during TLOFW (Total Loss of Feed Water) accident. In the analysis, the distribution of thermal equilibrium quality and local liquid fraction in the horizontal U-tube was also investigated. In order to experimentally investigate the condensation phenomena and natural convection in PAFS, a test loop with a single horizontal U-tube and PCCT is under construction at KAERI (Korea Atomic Energy

  6. Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET.

    Science.gov (United States)

    Shalom-Feuerstein, Ruby; Serror, Laura; Aberdam, Edith; Müller, Franz-Josef; van Bokhoven, Hans; Wiman, Klas G; Zhou, Huiqing; Aberdam, Daniel; Petit, Isabelle

    2013-02-01

    Ectodermal dysplasia is a group of congenital syndromes affecting a variety of ectodermal derivatives. Among them, ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) syndrome is caused by single point mutations in the p63 gene, which controls epidermal development and homeostasis. Phenotypic defects of the EEC syndrome include skin defects and limbal stem-cell deficiency. In this study, we designed a unique cellular model that recapitulated major embryonic defects related to EEC. Fibroblasts from healthy donors and EEC patients carrying two different point mutations in the DNA binding domain of p63 were reprogrammed into induced pluripotent stem cell (iPSC) lines. EEC-iPSC from both patients showed early ectodermal commitment into K18(+) cells but failed to further differentiate into K14(+) cells (epidermis/limbus) or K3/K12(+) cells (corneal epithelium). APR-246 (PRIMA-1(MET)), a small compound that restores functionality of mutant p53 in human tumor cells, could revert corneal epithelial lineage commitment and reinstate a normal p63-related signaling pathway. This study illustrates the relevance of iPSC for p63 related disorders and paves the way for future therapy of EEC. PMID:23355677

  7. Development of a New Condensation Heat Transfer Model for the Nearly Horizontal Tube of the APR+ PAFS (Passive Auxiliary Feed-water System)

    International Nuclear Information System (INIS)

    Korea Atomic Energy Research Institute (KAERI) has recently conducted PASCAL experiment to confirm the performance of PAFS. From the work, it is founded that the condensation heat transfer coefficient predicted by best estimated safety analysis code MARS (Multi-dimensional Analysis of Reactor Safety) was underestimated compared to the experimental data. Shah correlation embedded in MARS code is the typical model using the empirical two-phase multiplier to determine condensation heat transfer coefficient for annular flow in the condensing tube. On the other hand, the PASCAL experiment indicated that a stratified-wavy flow generally tends to occur in the downward inclined tube of the condensation heat exchanger. Therefore, in order to improve the prediction capability of safety analysis codes for PAFS, the present study has proposed a new condensation heat transfer model package for the nearly horizontal tube, which determines mechanistically the local heat transfer coefficient based on the flow regimes. To enhance prediction capability of one-dimensional best estimated code MARS for the PAFS of the Korean 3.5 generation nuclear power plant APR+, a new condensation heat transfer model package has been developed. The model package consists of the one-dimensional separated model for the void fraction, a flow regime model based on wetted angle, and the condensation heat transfer correlations. The model package considers the inclination angle of the condensing tube and various flow regimes that are expected in the tube during condensation process

  8. Coseismic Dip Slip Distribution of the 1 Apr 2007 Solomon Islands Mw8.1 Earthquake from a Fully Bayesian Inversion

    Science.gov (United States)

    Chen, T.

    2009-12-01

    102 uplift and subsidence measurements over the southeastern end of the rupture zone from two field surveys shortly after 1 Apr 2007 Solomon Islands Earthquake provide a unique geodetic constraint in the following inversion of distributed slip. In the conventional inversion of geodetic data for spatial distribution of fault slip the solution is maintained by minimizing the second-order spatial derivative of slip and the smoothing parameter is often selected subjectively at the bend of the trade-off curve of misfit as a function of slip roughness. A fully Bayesian slip inversion method[Fukuda et al.,2008] is used to overcome the deficiency of selecting the smoothing parameter subjectively. The smoothing parameter is estimated with the distributed slip at the same time under a unified theoretical Bayesian framework. The joint posterior probability density function of distributed slip and smoothing parameter is formulated using Bayes’ theorem and sampled with Markov chain Monte Carlo method. I will apply this method to coseismic slip distribution associated with the 2007 Mw8.1 Solomon Islands earthquake and compare the results of this method with conventional method and the coseismic finite fault model of Furlong et al.[2009].

  9. Numerical Analysis of In-Vessel Retention using MARS-Ga for APR1400 under the Ga-based External Reactor Vessel Cooling

    International Nuclear Information System (INIS)

    To stabilize and terminate the severe accident through enhancing the coolability of the degraded core, this paper introduces an approach to avoid heat removal limit by replacing flooding material from the borated water to the liquid metal, gallium. The attractive properties such as the low melting point, high boiling point, and no reaction with water ensure that gallium can play an important role in nuclear safety as an alternative coolant in the gap between the vessel and the vessel insulation. The properties of liquid gallium compared to other materials are indicated. For the investigation on the effect of gallium for IVR-ERVCS, numerical simulation for severe accident in APR 1400 using MARS-LMR was performed. In this study, the numerical analysis of gallium-based IVR-ERVCS using MARS-LMR was performed. The range of temperature distribution in this system was considered as an important factor and then the possibility of ERVC using liquid gallium was confirmed. In addition, It will perform the sensitivity studies for the heat transfer area between liquid gallium and borated water to design the optimum ERVC using liquid gallium

  10. Development of a New Condensation Heat Transfer Model for the Nearly Horizontal Tube of the APR+ PAFS (Passive Auxiliary Feed-water System)

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Taehwan; Jeong, Jaejun; Yun, Byongjo [Pusan National Univ., Busan (Korea, Republic of); Kang, Kyongho; Park, Yusun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Cheon, Jong [KHNP Central Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    Korea Atomic Energy Research Institute (KAERI) has recently conducted PASCAL experiment to confirm the performance of PAFS. From the work, it is founded that the condensation heat transfer coefficient predicted by best estimated safety analysis code MARS (Multi-dimensional Analysis of Reactor Safety) was underestimated compared to the experimental data. Shah correlation embedded in MARS code is the typical model using the empirical two-phase multiplier to determine condensation heat transfer coefficient for annular flow in the condensing tube. On the other hand, the PASCAL experiment indicated that a stratified-wavy flow generally tends to occur in the downward inclined tube of the condensation heat exchanger. Therefore, in order to improve the prediction capability of safety analysis codes for PAFS, the present study has proposed a new condensation heat transfer model package for the nearly horizontal tube, which determines mechanistically the local heat transfer coefficient based on the flow regimes. To enhance prediction capability of one-dimensional best estimated code MARS for the PAFS of the Korean 3.5 generation nuclear power plant APR+, a new condensation heat transfer model package has been developed. The model package consists of the one-dimensional separated model for the void fraction, a flow regime model based on wetted angle, and the condensation heat transfer correlations. The model package considers the inclination angle of the condensing tube and various flow regimes that are expected in the tube during condensation process.

  11. Numerical Study on the Effect of Reactor Internal Structure Geometry Treatment Method on the Prediction Accuracy for Scale-down APR+ Flow Distribution

    International Nuclear Information System (INIS)

    Internal structures, especially those located in the upstream of a reactor core, may have a significant influence on the core inlet flow rate distribution depending on both their shapes and the relative distance between the internal structures and the core inlet. In this study, to examine the effect of the reactor internal structure geometry treatment method on the prediction accuracy for the scale-down APR+ flow distribution, simulations with real geometry modeling were conducted using ANSYS CFX R.14, a commercial computational fluid dynamics software, and the predicted results were compared with those of the porous medium assumption. It was concluded that the core inlet flow distribution could be predicted more accurately by considering the real geometry of the internal structures located in the upstream of the core inlet. Therefore, if sufficient computational resources are available, an exact representation of these internal structures, for example, lower support structure bottom plate and ICI nozzle support plate, is needed for the accurate simulation of the reactor internal flow

  12. Observations of TeV gamma-rays from Mrk 421 during Dec. 2005 to Apr. 2006 with the TACTIC telescope

    CERN Document Server

    Yadav, K K; Tickoo, A K; Rannot, R C; Godambe, S; Koul, M K; Dhar, V K; Thoudam, S; Bhatt, N; Bhattacharya, S; Chanchalani, K; Goyal, H C; Kaul, R K; Kothari, M; Kotwal, S; Koul, R; Sahayanathan, S; Sharma, M; Venugopal, K

    2007-01-01

    The TACTIC $\\gamma$-ray telescope has observed Mrk 421 on 66 clear nights from Dec. 07, 2005 to Apr. 30, 2006, totalling $\\sim$ 202 hours of on-source observations. Here, we report the detection of flaring activity from the source at $\\geq$ 1 TeV energy and the time-averaged differential $\\gamma$-ray spectrum in the energy range 1-11 TeV for the data taken between Dec. 27, 2005 to Feb. 07, 2006 when the source was in a relatively higher state as compared to the rest of the observation period. Analysis of this data spell, comprising about $\\sim$97h reveals the presence of a $\\sim 12.0 \\sigma$ $\\gamma$-ray signal with daily flux of $>$ 1 Crab unit on several days. A pure power law spectrum with exponent $-3.11\\pm0.11$ as well as a power law spectrum with an exponential cutoff $(\\Gamma = -2.51\\pm0.26$ and $E_0=(4.7\\pm2.1) TeV)$ are found to provide reasonable fits to the inferred differential spectrum within statistical uncertainties. We believe that the TeV light curve presented here, for nearly 5 months of ext...

  13. Les westerns de John Ford : Du libéralisme d’avant-guerre au conservatisme d’après-guerre

    Directory of Open Access Journals (Sweden)

    Jean-Pierre Esquenazi

    2012-05-01

    Full Text Available L’article propose un moyen de mesurer l’influence sur les cinéastes du milieu dans lequel ils vivent. Sont examinés trois ensembles de westerns de John Ford (réalisés avant guerre, dans l’immédiat après guerre et dans la décennie 1955-1965. Chaque groupe est lié à une situation particulière de l’institution hollywoodienne et de la communauté des cinéastes. L’étude de la mise en scène de scènes récurrentes dans tous ces films révèle des différences pertinentes. Celles-ci peuvent être comprises comme des réactions à l’actualité sociale et politique de Hollywood. The article proposes a way to measure the influence on filmmakers of the environment in which they live. Three wholes of westerns, produced during the pre-war, during the immediate post war and during the decade 1955-1965, are reviewed. Each group is linked to a particular situation of the Hollywood industry. The study of the mise en scene of recurrent scenes in these films reveals relevant differences. These can be understood as reactions to the social and political state of the Hollywood industry.

  14. A study on Requirements of Data Base Translator for APR1400 Computerized Procedure System at Shin-Hanul unit 1 and 2

    International Nuclear Information System (INIS)

    The CPS is one of the Man Machine Interface (MMI) resources and the CPS can directly display plant graphic objects which are in the Digital Control System (DCS). And the CPS can send a request to DCS to provide DCS screen which is called step support display through DCS link button on a computerized procedure. The procedure writers can insert DCS graphic information to computerized procedure through data base which is provided by CPS Editing System (CPSES). The data base which is provided by CPSES conforms to the naming rule of DCS graphic objects. The naming rule of DCS graphic objects is defined by vendor thus status of DCS graphic objects which are in computerized procedure at Shin-Kori plant cannot be displayed on CPS at Shin-Hanul plant. To use computerized procedure which is written by other plant procedure writer, DCS graphic objects shall be translated by its plant data base. This paper introduces requirements of data base translator to reduce translation and re-inserting graphic objects burden. This paper introduces the requirements of data base translator of CPSES for APR1400 CPS at Shin-Hanul unit 1 and 2. The translator algorithms shall be tested to update data base of CPSES effectively. The prototype of translator is implemented and is being tested using real plant DB. This translator can be applied to Shin- Hanul unit1 and 2 through software V and V

  15. Anti-leukaemic effects induced by APR-246 are dependent on induction of oxidative stress and the NFE2L2/HMOX1 axis that can be targeted by PI3K and mTOR inhibitors in acute myeloid leukaemia cells.

    Science.gov (United States)

    Ali, Dina; Mohammad, Dara K; Mujahed, Huthayfa; Jonson-Videsäter, Kerstin; Nore, Beston; Paul, Christer; Lehmann, Sören

    2016-07-01

    The small molecule APR-246 (PRIMA-1(MET) ) is a novel drug that restores the activity of mutated and unfolded TP53 protein. However, the mechanisms of action and potential off-target effects are not fully understood. Gene expression profiling in TP53 mutant KMB3 acute myeloid leukaemia (AML) cells showed that genes which protected cells from oxidative stress to be the most up-regulated. APR-246 exposure also induced reactive oxygen species (ROS) formation and depleted glutathione in AML cells. The genes most up-regulated by APR-246, confirmed by quantitative real time polymerase chain reaction, were heme oxygenase-1 (HMOX1, also termed HO-1), SLC7A11 and RIT1. Up-regulation of HMOX1, a key regulator of cellular response to ROS, was independent of TP53 mutational status. NFE2L2 (also termed Nrf2), a master regulator of HMOX1 expression, showed transcriptional up-regulation and nuclear translocation by APR-246. Down-regulation of NFE2L2 by siRNA in AML cells significantly increased the antitumoural effects of APR-246. The PI3K inhibitor wortmannin and the mTOR inhibitor rapamycin inhibited APR-246-induced nuclear translocation of NFE2L2 and counteracted the protective cellular responses to APR-246, resulting in synergistic cell killing together with APR-246. In conclusion, ROS induction is important for antileukaemic activities of APR-246 and inhibiting the protective response of the Nrf-2/HMOX1 axis using PI3K inhibitors, enhances the antileukaemic effects. PMID:26991755

  16. L'aprenentatge de l'anglès a través de l'educació física : el programa 'Mou-te i aprèn'. English language acdquisition through Physical Education: the 'Mou-te i aprèn' programme.

    OpenAIRE

    Coral, Josep

    2010-01-01

    L’objecte d’estudi d’aquest article és la relació entre l’educació física i l’aprenentatge de la llengua anglesa, per mitjà de l’enfocament educatiu AICLE (CLIL, en anglès), concretat en el programa Mou-te i aprèn. Pel que fa a l’educació física es fonamenta en la metodologia d’instrucció directa: global pura, anàlisi progressiu i anàlisi seqüencial, complementada amb estratègies d’aprenentatge cooperatiu. L’educació física és una forma diferent i excel·lent d’aprendre la llengua. La combinac...

  17. Récupération après reconstruction du ligament croisé antérieur et prévention des ruptures : étude biomécanique d'un mouvement pluri-articulaire

    OpenAIRE

    Pairot de Fontenay, Benoît

    2014-01-01

    La reconstruction chirurgicale est le traitement préconisé après rupture du Ligament Croisé Antérieur (LCA) chez les patients sportifs. Cette opération est suivie d'une longue période de rééducation et les résultats en termes de reprise du sport et de récidive ne sont pas totalement satisfaisants. Ainsi ce travail s'articule autour de deux objectifs : l'amélioration de la récupération après lésion du LCA et la prévention des primo-ruptures. Dans un premier temps, nous avons évalué les altérat...

  18. L'Arabie du Sud et la mer du IIIème siècle av. au VIème siècle apr. J.‑C.

    OpenAIRE

    Schiettecatte, Jérémie

    2012-01-01

    Etude de l'évolution du commerce maritime en Arabie du Sud du 3e siècle avant au 6e siècle après et de l'évolution des ports et du tracé des voies de navigation en fonction du contexte politique plus large (évolution de l'empire romain, de la Perse sassanide).

  19. Phylogenetic Diversity and Spatial Distribution of the Microbial Community Associated with the Caribbean Deep-water Sponge Polymastia cf. corticata by 16S rRNA, aprA, and amoA Gene Analysis

    OpenAIRE

    Meyer, Birte; Kuever, Jan

    2008-01-01

    Denaturing gradient gel electrophoresis (DGGE)-based analyses of 16S rRNA, aprA, and amoA genes demonstrated that a phylogenetically diverse and complex microbial community was associated with the Caribbean deep-water sponge Polymastia cf. corticata Ridley and Dendy, 1887. From the 38 archaeal and bacterial 16S rRNA phylotypes identified, 53% branched into the sponge-specific, monophyletic sequence clusters determined by previous studies (considering predominantly shallow-water sponge species...

  20. "Mēness aptiekas" farmaceitiskās aprūpes pakalpojumu kvalitātes izvērtējums un pilnveides iespējas

    OpenAIRE

    Matute, Anete

    2016-01-01

    Maģistra darbā „Mēness aptiekas” farmaceitiskās aprūpes pakalpojumu kvalitātes izvērtējums un pilnveides iespējas” autore, balstoties uz pakalpojumu kvalitātes novērtēšanas teorētiskajiem modeļiem, izvērtējusi „Mēness aptiekas” tīkla Jūrmalas aptieku sniegto pakalpojumu kvalitātes dažādas dimensijas. Mūsdienu apstākļos farmaceitiskā aprūpe ir kļuvusi par būtisku primārās veselības aprūpes sastāvdaļu, tādēļ šo pakalpojumu pieejamībai un kvalitātei tiek pievērsta aizvien lielāka uzmanība gan ...

  1. Análise do efeito não linear do patrimônio líquido no apreçamento de fundos de investimento em ações

    Directory of Open Access Journals (Sweden)

    Paulo Rogério Faustino Matos

    2012-01-01

    Full Text Available Este artigo faz uso do Capital Asset Pricing Model (CAPM, em sua versão canônica e com extensões não lineares, visando a apreçar um painel de 75 fundos de investimento em ações no Brasil, ao longo dos últimos 11 anos. O resultado sugere que a versão linear desse arcabouço não seja capaz de apreçar ou de prever retornos reais de fundos que possuam elevados patrimônio líquido (PL e outperformance, em relação ao índice da Bolsa de Valores de São Paulo (Ibovespa, corroborando evidências anteriores. A versão não linear com thresholds baseados no PL parece lidar melhor com a questão de alfas de Jensen significativos, apesar de ser estatisticamente indicada apenas para poucos fundos com elevado PL, mas baixa outperformance. Essa é uma evidência de que, apesar de o tamanho influenciar na gestão e, possivelmente, na performance de um fundo, a modelagem de apreçamento desse efeito deve ser feita linearmente.

  2. Coadministration of Hedera helix L. Extract Enabled Mice to Overcome Insufficient Protection against Influenza A/PR/8 Virus Infection under Suboptimal Treatment with Oseltamivir.

    Science.gov (United States)

    Hong, Eun-Hye; Song, Jae-Hyoung; Shim, Aeri; Lee, Bo-Ra; Kwon, Bo-Eun; Song, Hyuk-Hwan; Kim, Yeon-Jeong; Chang, Sun-Young; Jeong, Hyeon Gun; Kim, Jong Geal; Seo, Sang-Uk; Kim, HyunPyo; Kwon, YongSoo; Ko, Hyun-Jeong

    2015-01-01

    Several anti-influenza drugs that reduce disease manifestation exist, and although these drugs provide clinical benefits in infected patients, their efficacy is limited by the emergence of drug-resistant influenza viruses. In the current study, we assessed the therapeutic strategy of enhancing the antiviral efficacy of an existing neuraminidase inhibitor, oseltamivir, by coadministering with the leaf extract from Hedera helix L, commonly known as ivy. Ivy extract has anti-inflammatory, antibacterial, antifungal, and antihelminthic properties. In the present study, we investigated its potential antiviral properties against influenza A/PR/8 (PR8) virus in a mouse model with suboptimal oseltamivir that mimics a poor clinical response to antiviral drug treatment. Suboptimal oseltamivir resulted in insufficient protection against PR8 infection. Oral administration of ivy extract with suboptimal oseltamivir increased the antiviral activity of oseltamivir. Ivy extract and its compounds, particularly hedrasaponin F, significantly reduced the cytopathic effect in PR8-infected A549 cells in the presence of oseltamivir. Compared with oseltamivir treatment alone, coadministration of the fraction of ivy extract that contained the highest proportion of hedrasaponin F with oseltamivir decreased pulmonary inflammation in PR8-infected mice. Inflammatory cytokines and chemokines, including tumor necrosis factor-alpha and chemokine (C-C motif) ligand 2, were reduced by treatment with oseltamivir and the fraction of ivy extract. Analysis of inflammatory cell infiltration in the bronchial alveolar of PR8-infected mice revealed that CD11b+Ly6G+ and CD11b+Ly6Cint cells were recruited after virus infection; coadministration of the ivy extract fraction with oseltamivir reduced infiltration of these inflammatory cells. In a model of suboptimal oseltamivir treatment, coadministration of ivy extract fraction that includes hedrasaponin F increased protection against PR8 infection that could be

  3. Coadministration of Hedera helix L. Extract Enabled Mice to Overcome Insufficient Protection against Influenza A/PR/8 Virus Infection under Suboptimal Treatment with Oseltamivir.

    Directory of Open Access Journals (Sweden)

    Eun-Hye Hong

    Full Text Available Several anti-influenza drugs that reduce disease manifestation exist, and although these drugs provide clinical benefits in infected patients, their efficacy is limited by the emergence of drug-resistant influenza viruses. In the current study, we assessed the therapeutic strategy of enhancing the antiviral efficacy of an existing neuraminidase inhibitor, oseltamivir, by coadministering with the leaf extract from Hedera helix L, commonly known as ivy. Ivy extract has anti-inflammatory, antibacterial, antifungal, and antihelminthic properties. In the present study, we investigated its potential antiviral properties against influenza A/PR/8 (PR8 virus in a mouse model with suboptimal oseltamivir that mimics a poor clinical response to antiviral drug treatment. Suboptimal oseltamivir resulted in insufficient protection against PR8 infection. Oral administration of ivy extract with suboptimal oseltamivir increased the antiviral activity of oseltamivir. Ivy extract and its compounds, particularly hedrasaponin F, significantly reduced the cytopathic effect in PR8-infected A549 cells in the presence of oseltamivir. Compared with oseltamivir treatment alone, coadministration of the fraction of ivy extract that contained the highest proportion of hedrasaponin F with oseltamivir decreased pulmonary inflammation in PR8-infected mice. Inflammatory cytokines and chemokines, including tumor necrosis factor-alpha and chemokine (C-C motif ligand 2, were reduced by treatment with oseltamivir and the fraction of ivy extract. Analysis of inflammatory cell infiltration in the bronchial alveolar of PR8-infected mice revealed that CD11b+Ly6G+ and CD11b+Ly6Cint cells were recruited after virus infection; coadministration of the ivy extract fraction with oseltamivir reduced infiltration of these inflammatory cells. In a model of suboptimal oseltamivir treatment, coadministration of ivy extract fraction that includes hedrasaponin F increased protection against PR8

  4. Inhibitory effect of cinnamaldehyde, derived from Cinnamomi cortex, on the growth of influenza A/PR/8 virus in vitro and in vivo.

    Science.gov (United States)

    Hayashi, K; Imanishi, N; Kashiwayama, Y; Kawano, A; Terasawa, K; Shimada, Y; Ochiai, H

    2007-04-01

    We have investigated the inhibitory effect of trans-cinnamaldehyde (CA), one of the principal constituents of essential oil derived from Cinnamomi cortex, on the growth of influenza A/PR/8 virus in vitro and in vivo. When 1-h drug treatment was initiated at various times post-infection (p.i.) in Madin-Darby canine kidney cells using a fixed dose of CA (40 microM), the maximum inhibitory effect (29.7% virus yield of control) was obtained when drug treatment was started at 3h p.i. Under the same treatment schedule, CA inhibited the virus growth in a dose-dependent manner (20-200 microM), and, at 200 microM, the virus yield was reduced to an undetectable level. RT-PCR and SDS-PAGE analyses showed that CA inhibited viral protein synthesis at the post-transcriptional level. In mice infected with the lung-adapted PR-8 virus, inhalation (50mg/cage/day) and nasal inoculation (250 microg/mouse/day) of CA significantly increased survival rates on the 8 days to 100% and 70%, respectively, in contrast to a survival rate of 20% in the untreated control group. Importantly, inhalation of CA caused virus yield reduction by 1 log in bronchoalveolar lavage fluid on day 6 after infection, compared with that of the untreated control group. These findings might provide further support to the empirical indication of Cinnamomi cortex-containing Kampo medicines for acute respiratory infectious diseases. PMID:17303260

  5. Première expérience de l'utilisation du Misoprostol comme soin après avortement (SAA) à Libreville, Gabon

    Science.gov (United States)

    Mayi-Tsonga, Sosthène; Minkobame, Ulysse; Mbila, Arielle; Assoumou, Pamphile; Diop, Ayisha; Winikoff, Beverly

    2014-01-01

    Introduction Une étude a été menée afin de déterminer le taux d'acceptabilité de 400µg de misoprostol par voie sublinguale comme traitement de première intention de l'avortement incomplet et de préciser le taux d'avortement complet ou vacuité utérine. Méthodes Les femmes éligibles avaient un diagnostic clinique d'avortement incomplet avec une taille utérine inférieure à celle d'un utérus de 12 semaines d'aménorrhées (SA). Chacune a reçu 400µg de misoprostol par voie sublinguale. Les femmes ont été revues après une semaine. A J7, celles qui n'avaient pas complètement expulsé ont eu le choix entre une nouvelle consultation de suivi à J14 et la pratique d'une évacuation chirurgicale immédiate. Résultats 145 patientes ont été éligibles et ont toutes accepté la méthode (100%). L’âge moyen était de 25,9 ± 6 ans. A J7, 120 patientes étaient guéries (85,7%). A J14, le taux de réussitea été de 95,7% soit 134 patientes guéries. Les patientes guéries ont déclaré être très satisfaites (57,5%), satisfaites (41,8%) et insatisfaite (0,7%). Au total,128 femmes (95,5%) ont dit être prêtes à utiliser de nouveau le misoprostol comme méthode d’évacuation utérine en cas d'avortement incomplet. Conclusion L’étude démontre que le 400µg misoprostol par voie sublinguale nous permet de prendre en charge d'une manière adéquate l'avortement incomplet surtout dans les pays à faible ressource et notamment dans les structures sanitaires de première ligne ou éloignées. PMID:25469194

  6. Croire après la bombe : les interactions entre violence, religion et développement au Sri Lanka

    Directory of Open Access Journals (Sweden)

    Indika Bulankulame

    2013-03-01

    Full Text Available Pendant les trente ans qu’a duré la guerre civile au Sri Lanka, de nombreux citoyens ont été touchés par des attentats à la bombe destinés à perturber la vie quotidienne, non seulement dans les zones de guerre mais aussi dans les quartiers urbains, particulièrement à Colombo, la capitale. Si beaucoup ont perdu la vie, d’autres ont survécu, mais restent profondément meurtris, handicapés et traumatisés. Le présent article explore la signification de la « survie » telle que l’ont éprouvée les personnes dotées du nouveau statut de « victimes d’attentats à la bombe ». Son auteur s’interroge sur la capacité des survivants à assumer leur rôle de soutien de famille et/ou à faire face aux graves bouleversements économiques consécutifs aux profonds changements survenus dans leur vie. L’article constate de manière générale qu’en raison de la perte de revenus et de l’incapacité de participer pleinement à l’économie de marché, les survivants sont relégués à la marge des grands débats sur le développement et des possibilités qui en découleraient. La fin des hostilités a marqué un tournant clair en faveur du développement du Sri Lanka et, dans cette période cruciale d’après-guerre, il importe de se pencher sur les différentes façons dont la religion peut répondre aux besoins des survivants. C’est pourquoi l’interaction dynamique entre religion, violence politique et développement est mise en relief. Dans l’examen des mécanismes d’adaptation et de survie, il est question des réponses qu’offre la religion à la mondialisation (néolibérale tributaire du marché et à l’exposition à la terreur et à la violence, en atténuant l’expérience des traumatismes et en permettant aux survivants de se confronter à la réalité au quotidien.

  7. Effects of cell differentiation on replication of A/WS/33, WSN, and A/PR/8/34 influenza viruses in mouse brain cell cultures: biological and immunological characterization of products.

    OpenAIRE

    Bradshaw, G L; Schlesinger, R W; Schwartz, C D

    1989-01-01

    The responses of mouse embryo brain (MEB) cell cultures and of Madin-Darby canine kidney cells and chicken embryo fibroblasts to infection with A/PR/8/34 (PR8), A/WS/33 (WS), or the neurovirulent WSN variant were compared in terms of (i) single-cycle yields of hemagglutinating and associated neuraminidase (NA) activities and plaque-forming particles, the latter with or without trypsin activation [PFU(TR++) or PFU(TR--), respectively], and (ii) expression of nucleoprotein (NP), M1, and NS1 pro...

  8. 冷战后法国外交政策的调整%La rénovation de la politique diplomatique en France aprés la Guerre froide

    Institute of Scientific and Technical Information of China (English)

    汪波

    2002-01-01

    Le gouvemement francais a rénové sa politique diplomatique après la guerre froide. Cette rénovation consiste à coopérer avec les Etats-Unis au sein de LOTAN, à participer d′avantage au proeessus de paix au Moyen-Orient et à exercer plus dinfluence sur lesaffaires africaines. Basée sur une reconnaissance du changement de la situation internationale, cette rénovation a pour objectif de consolider la position de la France au sein de la communauté internationale.

  9. L’exclusion des scientifiques allemands et de la langue allemande des congrès scientifiques internationaux après la Première Guerre mondiale

    OpenAIRE

    Reinbothe, Roswitha

    2013-01-01

    Après la Première Guerre mondiale les académies des sciences des pays alliés décidèrent de boycotter les scientifiques allemands et la langue allemande et fondèrent en même temps de nouvelles organisations scientifiques internationales : le Conseil international de recherches pour les sciences, qui chapeautait des unions internationales dans les disciplines les plus importantes, et l’Union académique internationale pour les sciences de l’homme. Les langues principales de ces organisations éta...

  10. Effet du numéro d'oestrus et du nombre de jours après le vêlage sur la probabilité de conception chez les vaches laitières

    DEFF Research Database (Denmark)

    Friggens, Nic; Labouriau, Rodrigo

    été observés quotidiennement pour toutes les vaches, du vêlage jusqu'à la gestation confirmée ou jusqu'à deux cent quatre-vingt dix jours après le vêlage. Des inséminations ont été effectuées à chaque chaleur observée à partir du trente-cinquième jour post partum jusqu'à ce que la vache ait été jugée...

  11. Māsas rīcība pēcoperācijas brūču aprūpē ķirurģijas nodaļā

    OpenAIRE

    Spruntule, Inga

    2016-01-01

    Bakalaura darba tēma „Māsas rīcība pēcoperācijas brūču aprūpē ķirurģijas nodaļā” . Tēmas aktualitāti nosaka tas, ka ik dienu slimnīcās veic neskaitāmas operācijas un infekcija ir viena no komplikācijām pēcoperācijas periodā. Inficēšanās iemesli ir dažādi. Roku nemazgāšana ir viens no galvenajiem veidiem, kā izplatās infekcija slimnīcās. Ir aktuāli noskaidrot māsas rīcību pēcoperācijas brūču aprūpē, jo aseptikas un antiseptikas, roku mazgāšana un dezinfekcija, kā arī cimdu lietošana var mazi...

  12. Māsu izpratnes pilnveide par pacientu izglītošanu primārajā un sekundārajā veselības aprūpē

    OpenAIRE

    Fridrihsone, Baiba

    2016-01-01

    Pacientu izglītošana ir māsas pienākums, tomēr, māszinības programmās, kā arī veselības aprūpes iestādēs, pacientu izglītošana tiek veikta nepilnīgi vai netiek veikta nemaz. Problēmas risināšanai tika izvirzīts mērķis: izzināt kā pilnveidot māsu izpratni par pacientu izglītošanu primārajā un sekundārajā veselības aprūpē. Pētāmā grupa bija Latvijas Universitātes, Medicīnas fakultātes, profesionālās bakalaura studiju programmas (PBSP) “Māszinības” 4.kursa studenti, kuri pārstāvēja sešas māsu ap...

  13. L’aprenentatge de l’anglès a través de l’educació física: el programa ‘Mou-te i aprèn’ English language acquisition through physical education: the ‘Mou-te i aprèn’ programme El aprendizaje del inglés a través de la educación física: el programa ‘Mou-te i aprèn’

    Directory of Open Access Journals (Sweden)

    Josep Coral i Mateu

    2011-09-01

    Full Text Available L’objecte d’estudi d’aquest article és la relació entre l’educació física i l’aprenentatge de la llengua anglesa, per mitjà de l’enfocament educatiu AICLE (CLIL, en anglès, concretat en el programa Mou-te i aprèn. Pel que fa a l’educació física es fonamenta en la metodologia d’instrucció directa: global pura, anàlisi progressiu i anàlisi seqüencial, complementada amb estratègies d’aprenentatge cooperatiu. L’educació física és una forma diferent i excel·lent d’aprendre la llengua. La combinació de les diferents metodologies i tècniques són molt efectives per millorar alhora el llenguatge, la motricitat i la salut. ______________________________________________ L’objet d’étude de cet article est la relation entre ’éducation physique et l’apprentissage de la langue anglaise, grâce à la perspective éducative Content and Language Integrated Learning (CLIL, concrétisée dans le programme Mou-te i aprèn. En ce qui concerne l’éducation physique, elle est fondée sur la méthodologie d’instruction directe, globale, pure, d’analyse progressive et d’analyse séquentielle, complétée par des stratégies d’apprentissage coopératif. L’éducation physique est une manière différente et excellente d’apprendre la langue. La combinaison des différentes méthodologies et techniques est tout à fait effective pour améliorer la langue, la motricité de même que la santéThe aim of this article is to explore the relationship between physical education and learning the English language through the CLIL (Content and Language Integrated Learning approach, implemented through the Mou-te i aprèn [‘Move yourself and learn’] programme. With regard to physical education it is based on the methodology of direct instruction: pure global, progressive analysis and sequential analysis, supplemented with cooperative learning strategies. Physical education is a different, effective way to learn the

  14. L’aprenentatge de l’anglès a través de l’educació física: el programa ‘Mou-te i aprèn’ English language acquisition through physical education: the ‘Mou-te i aprèn’ programme El aprendizaje del inglés a través de la educación física: el programa ‘Mou-te i aprèn’

    OpenAIRE

    Josep Coral i Mateu

    2011-01-01

    L’objecte d’estudi d’aquest article és la relació entre l’educació física i l’aprenentatge de la llengua anglesa, per mitjà de l’enfocament educatiu AICLE (CLIL, en anglès), concretat en el programa Mou-te i aprèn. Pel que fa a l’educació física es fonamenta en la metodologia d’instrucció directa: global pura, anàlisi progressiu i anàlisi seqüencial, complementada amb estratègies d’aprenentatge cooperatiu. L’educació física és una forma diferent i excel·lent d’aprendre la llengua. La combinac...

  15. L’abdication du Congrès après le 11 septembre : crise constitutionnelle ou politique ?

    Directory of Open Access Journals (Sweden)

    Maya KANDEL

    2011-09-01

    Full Text Available L’effondrement des tours jumelles de Manhattan le 11 septembre 2001 a renversé le rapport existant entre législatif et exécutif américains. Alors que certains avaient pu qualifier George W. Bush après son élection de « premier président post-impérial » face à un Congrès en pleine reconquête de ses prérogatives depuis la fin de la guerre froide, l’entrée des Etats-Unis dans la « guerre contre la terreur » a vu le retour d’une présidence impériale, et réduit les parlementaires à un rôle de quasi figuration. Historiquement, l’évolution semble attendue. Les phases d’extraversion de l’Amérique ont toujours correspondu à une affirmation de la prééminence présidentielle. Plus encore, en temps de crise et dès lors que la sécurité du peuple est en jeu, la prérogative constitutionnelle qui fait du président le commandant en chef des forces armées du pays lui donne une marge de manœuvre incomparable dans l’élaboration de la politique étrangère. Il était logique que le 11 septembre garantisse à Bush la victoire sur le Congrès dans la « compétition pour le privilège de conduire la politique étrangère du pays ». Les parlementaires se sont montrés particulièrement complaisants face à l’expansion des pouvoirs de l’exécutif, qu’ils ont souvent eux-mêmes autorisée – en particulier dans les mois qui ont suivi les attaques, puis par la suite, en raison de l’utilisation habile par Bush et le parti républicain d’une « politique de la peur » particulièrement efficace. Mais l’Administration Bush est allée beaucoup plus loin que cette simple logique. Par la pratique des signing statements, « déclarations de signature » ajoutées aux lois, le Président s’est accordé le droit d’interpréter, voire de choisir ou de corriger, certaines portions de la législation votée par le Congrès. Cette pratique n’a pas été inventée par Bush mais, qualitativement comme

  16. Confluences Méditerranée, n° 81, 2012/2, 236 p.Dossier : Algérie, 50 ans après

    OpenAIRE

    Mohammedi, Sidi Mohammed

    2015-01-01

    « L’Algérie fête cette année les 50 ans de son indépendance, une occasion pour revenir sur son parcours à la fois politique, économique et culturel. C’est l’objectif recherché par la revue Confluences Méditerranée à travers ce numéro consacré à « L’Algérie, 50 ans après » (p. 09). C’est ainsi qu’a ouvert Sid-Ahmed Souiah sa présentation en attirant l’attention que l’exhaustivité n’était pas recherchée pour choisir les thématiques retenues mais, plutôt, de présenter une variété de contribution...

  17. Aprèn història en anglès! Un projecte d’innovació de llengües estrangeres a l’Institut Julio Antonio de Móra d’Ebre

    OpenAIRE

    Loreto Meix-Boira

    2012-01-01

    Aprèn història en anglès! és un projecte d’innovació de llengües estrangeres creat per ensenyar història en anglès a estudiants de secundària la llengua materna dels quals no és l’anglès (CLIL, Content and Language Integrated Learning, també conegut com a AICLE, aprenentatge integrat de continguts i llengua estrangera ). El projecte consta de tres blocs que tracten aspectes polítics, socials, econòmics i culturals sobre el món antic, Egipte i Roma, i l’edat mitjana (Life in Ancient Egypt, Anc...

  18. La prévention du suicide chez l'adolescent hospitalisé après une tentative échouée: quel est le rôle infirmier ?

    OpenAIRE

    Chabanel, Fanny; Bagnoud, Perle; Roche-Meredith, Loriane; Dupuis, Patricia

    2012-01-01

    Plusieurs études menées dans des pays différents mettent en avant que le suicide des adolescents est un problème de santé publique de grande envergure. En effet, après plusieurs lectures d’articles de recherche, nous avons remarqué que dans la majorité des pays industrialisés le suicide des adolescents est une des trois premières causes de mortalité. Nous nous sommes donc questionnées à ce sujet et nous avons eu envie de connaître le rôle de l’infirmière quant à la prévention du suicide chez ...

  19. Apreçamento de opções sobre taxa de câmbio R$/US$ negociadas no Brasil: uma comparação entre os modelos Black e redes neurais artificiais

    Directory of Open Access Journals (Sweden)

    Leandro dos Santos Maciel

    2012-03-01

    Full Text Available No estudo aqui apresentado, aplicou-se um modelo de rede neural multicamadas para o apreçamento de calls sobre taxa de câmbio R$/US$, negociadas na Bolsa de Valores, Mercadorias & Futuros de São Paulo (BM&FBovespa, para o período de janeiro de 2004 a dezembro de 2007. A partir dos preços efetivamente praticados no mercado, comparou-se o desempenho entre essa técnica e o modelo de Black, utilizando-se métricas usuais de erro e testes estatísticos. Os resultados obtidos revelaram, em geral, a melhor adequação do modelo de inteligência artificial, em comparação ao modelo de Black, nos diferentes graus de moneyness.

  20. Professionnalisation à travers la socialisation internationale et les "usages de l'Europe". Le cas des organisations syndicales en Bulgarie, KNSB et KT Podkrepa, après 1989.

    OpenAIRE

    Spasova, Slavina

    2015-01-01

    Comment appréhender l’acteur syndical dans le changement des cycles historiques et « le passage, à la fin des années 80, d’une conjoncture économique à une autre, d’une forme syndicale à une autre ». (Mouriaux, René dans Launey, Michel 1990). En se passionnant par ce questionnement notre thèse de doctorat se penche sur l’étude de cas de la construction de l’acteur syndical et son rôle dans l’espace politique, économique et social en Bulgarie après 1989. Un pays qui à l’orée de l’instauration ...

  1. Caractéristiques spatiales de la couverture des buissons après différentes perturbations par le feu dans les Pyrénées

    OpenAIRE

    Montané, Francesc; Casals, Pere; Taull, Marc; Lambert, Bernard; Dale, Mark R.T.

    2009-01-01

    * Les empiètements boisés sur les prairies sont un phénomène mondial. Dans les Pyrénées, le feu a été utilisé comme un outil de gestion pour transformer une partie des empiètements boisés en prairies. * Cette étude vise à comparer les caractéristiques spatiales des couverts de buissons 4 ans après 4 différentes perturbations (feu prescrit, feu prescrit répété, feu spontané dans des buissons âgés de 20 ans et feu spontané dans buissons âgés de 5 ans), et aussi de comparer la couverture des bui...

  2. Magaly Del Vecchio-Drion, La Prise de Cordres et de Sebille, chanson de geste du xiiie siècle, édition d’après le ms. BN

    OpenAIRE

    Vecchio-Drion, Magaly Del

    2012-01-01

    La Prise de Cordres et de Sebille appartient au Cycle de Guillaume d’Orange, plus précisément, au Cycle des Narbonnais. Cet ensemble de chansons, qui se situe au moment des enfances de Guillaume, narre les exploits des frères du comte d’Orange après ce que l’on a coutume d’appeler le « département des fils Aymeri » et comprend les textes suivants : Aymeri de Narbonne, Narbonnais, Siège de Barbastre, Mort Aymeri de Narbonne. À ce noyau s’ajoutent Guibert d’Andrenas et La Prise de Cordres et de...

  3. Evaluation du matériel pour les obturations des restaurations préventives, avant et après un stress mécanique et thermal, étude in vitro

    OpenAIRE

    Chaskelis, Ivonne

    2014-01-01

    Le but de cette étude in vitro a été d’évaluer l’adaptation marginale de trois résines différentes utilisées pour le traitement des cavités minimales. 30 molaires humaines supérieures, désignées de façon randomisée, divisées en 3 groupes expérimentaux ont été soumises à des charges mécaniques et thermiques après avoir été obturées par 3 matériaux différents (groupe 1 : Optibond® FL + Optibond® FL, groupe 2 : Optibond® FL + premise® Flow, groupe 3 : Optibond® FL + Premise®). L’adaptation margi...

  4. Valutazione dell'appropriatezza dei ricoveri in un Policlinico Universitario: analisi mediante l'uso comparativo dei sistemi di classificazione isogravitá APR-DRG e Disease Staging e del PRUO

    Directory of Open Access Journals (Sweden)

    M. Volpe

    2003-05-01

    Full Text Available

    Obiettivi: valutare l’appropriatezza organizzativa dei ricoveri effettuati in un Policlinico Universitario attraverso la comparazione di due metodi, dei quali uno basato sui dati della scheda di dimissione ospedaliera ed utilizza, rispettivamente, i sistemi di classificazione iso-gravità APR-DRG e Disease Staging e l’altro sulla revisione delle cartelle cliniche mediante il PRUO.

    Metodi: oggetto di analisi sono i ricoveri ordinari effettuati nell’anno 2001 ed afferenti ai DRG inclusi nella delibera della Giunta Regionale del Lazio 864/2002 che recepisce il D.P.C.M. 29/11/2001 sui livelli essenziali di assistenza.

    Risultati: i risultati evidenziano che le due varianti del
    metodo basato sulla SDO (metodo APPRO mostrano quote di ricoveri inappropriati sovrapponibili rispetto al complesso dei ricoveri oggetto di analisi, ma con differenze anche rilevanti tra APR-DRG e Disease Staging in relazione ai singoli DRG considerati, riconducibili ai diversi algoritmi di attribuzione del livello di severità utilizzati dai due sistemi. L’analisi campionaria effettuata con il metodo PRUO su casi afferenti ai DRG della DGR 864/2002 caratterizzati da livelli di severità minimi evidenzia una proporzione di ricoveri inappropriati superiore a quella determinata tramite i metodi basati sulla SDO. Tale differenza è verosimilmente dovuta al ruolo del valore delle soglie percentuali di accettabilità individuate dalla Regione Lazio per ciascun DRG: le quote di ricoveri che eccedono tali soglie sono considerate inappropriate.

    Conclusioni: sulla base dei risultati ottenuti gli autori
    descrivono gli interventi organizzativi adottati per ottimizzare il contesto di erogazione delle prestazioni
    oggetto di analisi, discutono vantaggi e limiti dei metodi SDO-based e del metodo analitico PRUObased e ne propongono l

  5. Tarifa e Ocupação em Hotéis: provocando o modelo de apreçamento convencional

    Directory of Open Access Journals (Sweden)

    Eder Paschoal Pinto

    2010-07-01

    -style:italic; mso-bidi-font-style:normal;} p.Captulo, li.Captulo, div.Captulo {mso-style-name:Capítulo; mso-style-unhide:no; margin-top:12.0pt; margin-right:0cm; margin-bottom:12.0pt; margin-left:0cm; text-align:justify; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman","serif"; mso-fareast-font-family:"Times New Roman"; font-weight:bold; mso-bidi-font-weight:normal;} .MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-size:10.0pt; mso-ansi-font-size:10.0pt; mso-bidi-font-size:10.0pt;} @page WordSection1 {size:612.0pt 792.0pt; margin:70.85pt 3.0cm 70.85pt 3.0cm; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.WordSection1 {page:WordSection1;} -->

    Resumo

    O objetivo central deste trabalho é discutir a relação entre tarifa e taxa de ocupação em hotéis. As teorias de segmentação de clientes, composto mercadológico e estratégia de apreçamento foram aplicadas ao estudo. Os hotéis de Santos classificados como Turístico e Luxo foram escolhidos intencionalmente. Oitenta e três por cento deles responderam ao

  6. Aprèn història en anglès! Un projecte d’innovació de llengües estrangeres a l’Institut Julio Antonio de Móra d’Ebre

    Directory of Open Access Journals (Sweden)

    Loreto Meix-Boira

    2012-07-01

    Full Text Available Aprèn història en anglès! és un projecte d’innovació de llengües estrangeres creat per ensenyar història en anglès a estudiants de secundària la llengua materna dels quals no és l’anglès (CLIL, Content and Language Integrated Learning, també conegut com a AICLE, aprenentatge integrat de continguts i llengua estrangera . El projecte consta de tres blocs que tracten aspectes polítics, socials, econòmics i culturals sobre el món antic, Egipte i Roma, i l’edat mitjana (Life in Ancient Egypt, Ancient Rome i Middle Ages. Amb els materials creats per a aquest projecte, els estudiants tindran l’oportunitat de treballar amb textos atractius i amb una gran varietat d’activitats durant unes 140 hores. L’alumnat prendrà contacte amb les TIC (tecnologies de la informació i la comunicació, ja que part del material es troba a la xarxa i, a més, es tracta d’un projecte interdisciplinari, en el qual es treballen les ciències socials, l’anglès i les TIC. El material és adequat per utilitzar-lo amb alumnes de 12 a 15 anys.

  7. La chronologie du royaume de Qatabân du Ier siècle avant J.-C. au Ier siècle après J.-C.

    Directory of Open Access Journals (Sweden)

    Mounir Arbach

    2002-04-01

    Full Text Available Les nouvelles découvertes archéologiques et épigraphiques de ces dernières années, effectuées au cours des fouilles franco-italiennes à Tamna`, l'ancienne capitale du royaume de Qatabân, permettent d'établir une nouvelle chronologie des souverains de Qatabân entre le Ier siècle avant J.-C. et le Ier siècle après J.- C.The chronology of the kingdom of Qatabân, from the 1st century BC to the 1st century AD. Archaeological and epigraphical discoveries made in recent years by the Franco-Italian excavations at Tamna`, the ancient capital of the kingdom of Qatabân, allows us to establish a new chronology for the kings of Qatabân during the 1st century BC and the 1st century AD.

  8. Les travaux de défense des châteaux delphinaux pendant la guerre de Cent Ans. Etude des réparations d'après les comptes de châtellenies au XIVe siècle

    OpenAIRE

    Nicolas, Nathalie

    2000-01-01

    International audience Cet article propose d'éclairer l'étude monumentale des châteaux delphinaux situés aujourd'hui dans le département des Hautes-Alpes d'après les réparations enregistrées par les châtelains du Dauphiné, dans leur comptabilité annuelle, en particulier au cours des années 1360 à 1400.

  9. La voie foncière et administrative en appui à la voie écologique et agricole pour une gestion décentralisée des ressources naturelles dans le programme Après-Barrages au Sénégal

    Directory of Open Access Journals (Sweden)

    Vincke, PP.

    1994-01-01

    Full Text Available Natural Resources Management, From The Ecological To The Land Tenure And Administrative Process : The "Apres-Barrages" Experience In Senegal. To get over the difficulty of convincing rural population to apply scientifical and technical recommandations related to nature conservation, an institutional process has been initiated in order to create a framework prompting local popular support and that could result in integrated rural space development supported by natural ressources management.

  10. Tēvu bērnības pieredze, depresijas un trauksmes simptomi perinatālajā periodā un to saistība ar viņu iesaistīšanos jaundzimušā aprūpē

    OpenAIRE

    Vedeņejeva, Veronika

    2016-01-01

    Maģistra darba pētījuma mērķis ir longitudināli izpētīt, kāda saistība pastāv starp vīrieša bērnības pieredzi un viņa iesaisti jaundzimušā bērna aprūpē, kā arī, vai topošo tēvu psiholoģiskais stāvoklis bērna perinatālajā periodā paredz viņa iesaistīšanos jaundzimušā aprūpē. Pie tam bija nozīmīgi izprast vīrieša psiholoģiskā stāvokļa dinamiku perinatālajā periodā, un vai izmaiņas psiholoģiskajā stāvoklī ir nozīmīgs faktors vīrieša iesaistei sava bērna aprūpē. Maģistra darba pētījums sastāvēja ...

  11. Emocionālās izdegšanas sindroms garīgās veselības aprūpē strādājošo māsu vidū

    OpenAIRE

    Cvetkovs, Andrejs

    2016-01-01

    Maģistra darba tēma – “Emocionālās izdegšanas sindroms garīgās veselības aprūpē strādājošo māsu vidū”. Pētījuma mērķis ir noskaidrot sakarības starp emocionālā intelekta līmeni un emocionālā izdegšanas sindroma attīstības pakāpi garīgās veselības aprūpē strādājošajām māsām. Saskaņā ar pētījuma tēmu tika izvirzīta hipotēze – pastāv sakarība starp garīgās veselības aprūpē strādājošo māsu emocionālā intelekta līmeni un emocionālās izdegšanas sindroma attīstības pakāpi. Lai sasniegtu pētījuma mē...

  12. State of the Art der plastisch-rekonstruktiven Chirurgie aus Sicht der Gynäkologie

    Directory of Open Access Journals (Sweden)

    Nestle-Krämling, Carolin

    2012-12-01

    Full Text Available In Germany plastic-reconstructive techniques are used in gynecology for aesthetic reasons as well as for correction of congenital malformations, reconstructive surgery or defect coverage after tumour resection in the genital area, in the abdominal region and in breast surgery. The evolution of plastic and reconstructive surgery in gynecology comprises the hole spectrum of allogenic and autologous techniques in the field of aesthetic and reconstructive surgery.

  13. Tomographie par coherence optique pour le guidage de chirurgies minimalement invasives du rachis

    Science.gov (United States)

    Beaudette, Kathy

    Adolescent idiopathic scoliosis is a complex 3D deformity of the spine which requires surgical intervention in severe cases of the condition. The existing corrective procedure of scoliosis is very invasive; it involves a long incision and a large instrumentation, in addition to the fusion of a section of the spine. To improve postoperative conditions and to preserve patients' spinal flexibility, novel fusionless surgical approaches involving growth modulation are under investigation. With this objective in mind, a multidisciplinary team from École Polytechnique of Montreal and Sainte-Justine University Hospital Research Center is developing a surgical technique based on the insertion of micro-staples between vertebral growth plates and corresponding intervertebral disks. Each micro-staple passively modulates the vertebral growth on the convex side of the scoliotic curvature. This modulation modifies vertebral geometry which, for scoliotic patients, presents a wedging deformity. The modulation induced by these devices could lead to the correction of the curvature of the spine. This innovative procedure would preserve the flexibility of the spine as well as the health of intervertebral disks, in addition to being compatible with minimally invasive approaches. However, to be efficient, the micro-staples must be placed at the junction between the growth plate and the disk with a sub-millimeter precision. An intraoperative guiding system is therefore required to ensure the success of the intervention. Optical coherence tomography (OCT) is a promising candidate for this application. OCT is based on low-coherence interferometry and provides cross-sectional images with a resolution about 10 μm for a depth of 2 to 3 mm. This technique allows for the real-time acquisition of images and is compatible with endoscopy, thereby showing a potential for the intraoperative guidance of minimally invasive surgeries (MIS) of the spine. The main objective of this master's project is therefore to evaluate the possibility of using OCT to localize as well as identify spinal structures (such as growth plates, osseous tissue, intervertebral disks and connective tissue) and to guide the insertion of micro-staples. To attain this objective, an OCT handheld probe was designed and developed according to the surgical constraints of MIS performed by thoracoscopy (through the thorax). This probe has an external diameter of 17 mm and is 30 cm long. Coupled with a fibered interferometer, the axial and lateral resolutions of the probe are of 16 and 27 μm respectively. The OCT probe was used in vivo during an open surgery on a porcine model. Different tissues within the operative window (lung, muscles, osseous tissues and intervertebral disk) were imaged during the procedure. These preliminary in vivo tests demonstrated that the probe is capable of identifying different types of tissue with a good sensitivity and an adequate penetration depth. These results also showed that a visual inspection of the in vivo OCT images alone is not sufficient to localize the growth plates on the vertebrae. An ex vivo study using porcine vertebrae was therefore performed to identify quantitative markers in order to facilitate the interpretation of in vivo OCT images. OCT images were initially compared to corresponding histological sections. The ensuing results showed that the connective tissue layer presents a band pattern due to the birefringence properties of the collagen-rich tissue. The intervertebral disk was also shown to have a characteristic lamellar structure on OCT images. Lastly, within growth plate and osseous tissue locations, the OCT signal decay is monotonic, but with different attenuation coefficients (different slopes). Relative attenuation coefficients were therefore measured for each tissue (growth plate, osseous tissue, connective tissue and intervertebral disk) on several specimens and were compared. These results showed that growth plates present an average relative attenuation coefficient statistically different from the other tissues. An automatic growth plate segmentation algorithm was then developed and tested. The algorithm was applied to images from an ex vivo specimen of a porcine vertebra and successfully identified most of the growth plate (> 75%) amidst the osseous tissue of the vertebral body and the intervertebral disk. This master's project shows that OCT presents contrast, resolution and penetration depth that are sufficient for the identification of musculoskeletal structures of the spine. It is thus reasonable to believe that, ultimately, OCT could be used for the intraoperative guiding of the insertion of micro-staples during corrective surgeries of scoliosis.

  14. Status quo der plastisch-rekonstruktiven Chirurgie aus der Sicht der Mund-, Kiefer- und Gesichtschirurgie

    OpenAIRE

    Heiland, Max; Eichhorn, Wolfgang; Gröbe, Alexander; Hanken, Henning; Riecke, Björn; Smeets, Ralf; Al-Dam, Ahmed

    2012-01-01

    The prior aim of facial plastic-reconstructive surgery was and will be the adequate restitution of appearance and function so that patients with trauma- or tumorassociated defects as well as congenital malformations can be successfully rehabilitated. Nowadays, three major techniques are used to achieve this goal: local flaps, pedicled flaps and microsurgical flaps. This overview article describes in detail the three major techniques of facial plastic reconstructive surgery from past to presen...

  15. Standortbestimmung – Status quo der plastisch-rekonstruktiven Chirurgie aus der Sicht der Handchirurgie

    OpenAIRE

    Koulaxouzidis, Georgios; Stark, G. Björn

    2012-01-01

    Modern plastic-reconstructive surgery, much like hand surgery, repres a young and fast-developing surgical discipline. The principles of plastic surgery originate in the developmental stages of surgery and have considerable influence on hand surgery. Microsurgery, free or pedicled transfer of tissue, peripheral nerve surgery, plexus surgery, tendon transfers, arthroplasty, vascularized bone transfers, or toe to thumb transplants, are all performed while considering plastic surgical principles...

  16. Standortbestimmung – Status quo der plastisch-rekonstruktiven Chirurgie aus der Sicht der Handchirurgie

    Directory of Open Access Journals (Sweden)

    Koulaxouzidis, Georgios

    2012-12-01

    Full Text Available Modern plastic-reconstructive surgery, much like hand surgery, repres a young and fast-developing surgical discipline. The principles of plastic surgery originate in the developmental stages of surgery and have considerable influence on hand surgery. Microsurgery, free or pedicled transfer of tissue, peripheral nerve surgery, plexus surgery, tendon transfers, arthroplasty, vascularized bone transfers, or toe to thumb transplants, are all performed while considering plastic surgical principles and represent just a part of plastic surgical techniques which are daily applied in hand-surgical routine. They emphasize the intimate relationship and the mutual influence between the two disciplines. The future of plastic surgery is likely to include composite tissue allotransplantation, flap prefabrication, virtual surgical planning, application of growth factors to influence bone growth, fracture healing, angiogenesis, tendon healing or wound healing. Furthermore, the field of tissue engineering is likely to introduce novel materials, such as nerve conduits. All of the above may have direct influence on hand surgery and, therefore, the future of plastic and hand surgery is at least as intricately intertwined as was their past. They will remain related through the characteristics that led to their development: innovation, creativity, diversity and the search for individualized solutions.

  17. Status quo der plastisch-rekonstruktiven Chirurgie aus Sicht der Viszeralchirurgie

    Directory of Open Access Journals (Sweden)

    Kröpil, Feride

    2013-12-01

    Full Text Available The Art of Surgery has a very long tradition and is one of the earliest treatments for serious injuries of diverse causes. Due to achievements in anesthesia and intensive care medicine in the second half of the nineteenth century, postoperative morbidity and mortality have been appreciably reduced. Operative techniques could be expanded and new operative therapies could be introduced. Although the last two-hundred years have brought about increasing specialization in medicine and operative specialties have developed in multiple areas, the operative spectrum of the visceral surgeon has remained rather broad and diverse. Numerous operative procedures are carried out in the entire gastroi tract as well as the body surface. Many of these are to treat diseases, while others are of help in the plastic reconstruction of organs and the body surface. Thanks to specialization, among the positive developments are shortened operation time and length of hospital stay, as well as reduced postoperative morbidity and mortality. The advances in minimal-invasive surgery and the progress in surgical instruments and suturing techniques are some origins of these positive developments. This article cannot cover all possible resections and reconstructions of the visceral surgeon, but will instead concentrate on two major sites. The operative treatment of inguinal hernias is one of the oldest operations known to humanity. Because hernias are one of the most common operations of all visceral surgical procedures, their surgical therapy shall be particularly highlighted here. But the plastic and reconstructive possibilities of the visceral surgeon are by no means limited to hernia repair. So this manuscript will further provide insight into the resection and reconstruction possibilities of the esophagus, one of the most challenging procedures in this field.

  18. Status quo der plastisch-rekonstruktiven Chirurgie aus der Sicht der Mund-, Kiefer- und Gesichtschirurgie

    Directory of Open Access Journals (Sweden)

    Heiland, Max

    2012-12-01

    Full Text Available The prior aim of facial plastic-reconstructive surgery was and will be the adequate restitution of appearance and function so that patients with trauma- or tumorassociated defects as well as congenital malformations can be successfully rehabilitated. Nowadays, three major techniques are used to achieve this goal: local flaps, pedicled flaps and microsurgical flaps. This overview article describes in detail the three major techniques of facial plastic reconstructive surgery from past to present and gives an outlook on upcoming new techniques like the virtual planning of reconstructive measures.

  19. Segmentace trhu plastické chirurgie v ČR

    OpenAIRE

    Maříková, Pavla

    2011-01-01

    Main objective of my thesis is to recommend a marketing orientation for clinics through an understanding of why men and women undergo plastic surgery and what is their reason to start considering it. Because women use plastic surgery more than men, the study is mainly focused on them. Another target is to compare competing invasive and non-invasive cosmetic treatments. The research part is consisting of a quantitative research. Quantitative research is based on online questionnaire and distri...

  20. State of the Art der plastisch-rekonstruktiven Chirurgie aus Sicht der Gynäkologie

    OpenAIRE

    Nestle-Krämling, Carolin

    2012-01-01

    In Germany plastic-reconstructive techniques are used in gynecology for aesthetic reasons as well as for correction of congenital malformations, reconstructive surgery or defect coverage after tumour resection in the genital area, in the abdominal region and in breast surgery. The evolution of plastic and reconstructive surgery in gynecology comprises the hole spectrum of allogenic and autologous techniques in the field of aesthetic and reconstructive surgery.

  1. Correlation of serum vascular endothelial growth factor levels with plasma,serum and P-APR in breast cancer%乳腺癌患者血管内皮生长因子水平与外周血各成分的相关性

    Institute of Scientific and Technical Information of China (English)

    罗琼; 陶霖玉

    2009-01-01

    Objective To look for a better way to assay vascular endothelial growth factor(VEGF) and explore the correlation of serum VEGF levels with platelet and leucocyte count in breast cancer by comparison of peripheral blood plasma, serum and P-APR. Methods Blood samples were obtained from 42 patients with breast cancer and 20 healthy volunteers. Serum, plasma and P-APR samples were analyzed for VEGF using a commercially available sandwich ELISA, and assayed for semiquantitative measurement using microplatereader. At the same time, samples were analyzed by hematology analyzer. Results The level of VEGF in peripheral blood positively correlated to platelet (health control group: r=0.424, P=0.063) and leucocyte (health control group: r=0.443, P=0.050). The difference in VEGF values of P-APR between the localized breast cancer group and the health control group was statistically significant. Conclusion The level of VEGF in peripheral blood positively correlates to platelet and leucocyte. Platelet and leucocyte possibly secrete VEGF in vitro. Compared with serum and plasma, P-APR is the best section assaying VEGF in peripheral blood.%目的 寻求血管内皮生长因子(VEGF)的最佳检测方法并探讨VEGF水平与血小板、白细胞数量之间的关系.方法 采集42例乳腺癌患者(乳腺癌组)及20例健康志愿者(对照组)外周静脉血,用VEGF单克隆抗体ELISA法分别测定血清、血浆、P-APR VEGF水平,经酶标仪半定量,同时血细胞分析仪计数血小板、白细胞数量.结果 血清VEGF水平与血小板数量呈正相关(r=0.424,P=0.063),血清VEGF水平与白细胞数量呈正相关(r=0.443,P=0.050).P-APR中的VEGF含量在局限性乳腺癌组与对照组间的差异有统计学意义(P=0.007).结论 外周血VEGF水平与血小板、白细胞呈线性相关,血小板、白细胞在外周血中可分泌VEGF;相对血清、血浆,P-APR是外周血中VEGF检测的最佳成分.

  2. Monthly results of measurements: Apr 1997

    International Nuclear Information System (INIS)

    This report of the OPRI (Office of Protection against Ionizing Radiations) exposes the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, fishes), sea water around nuclear sites and other sites. The activities of various radioisotopes are presented in tables

  3. Le CFEY et après…

    Directory of Open Access Journals (Sweden)

    François Burgat

    2000-09-01

    Full Text Available La livraison des Chroniques Yéménites 2000 s'inscrit dans le droit fil de l'initiative heureuse prise en 1993 par Frank Mermier, tout en prolongeant un effort entrepris dans la livraison précédente : allégées des comptes rendus de recherche cantonnés désormais au rapport scientifique du Centre et à son site Internet, les Chroniques entendent plus que jamais présenter un vaste panorama de la recherche sur le Yémen ou de la production intellectuelle de ce pays. La revue est désormais dotée d'un...

  4. PACITA: volta no. 06 (Apr. 2014)

    OpenAIRE

    PACITA Consortium (Hrsg.)

    2015-01-01

    volta – Science, Technology and Society in Europe; No. 06 – April 2014PACITA (Parliaments and civil society in Technology Assessment) has been a four-year EU financed project under FP7 aimed at increasing the capacity and enhancing the institutional foundation for knowledge-based policy-making on issues involving science, technology and innovation, mainly based upon the diversity of practices in Parliamentary Technology Assessment (PTA). The key practices in focus have been interactive in the...

  5. PACITA: volta no. 08 (Apr. 2015)

    OpenAIRE

    PACITA Consortium (Hrsg.)

    2015-01-01

    volta – Science, Technology and Society in Europe; No. 08 – April 2015PACITA (Parliaments and civil society in Technology Assessment) has been a four-year EU financed project under FP7 aimed at increasing the capacity and enhancing the institutional foundation for knowledge-based policy-making on issues involving science, technology and innovation, mainly based upon the diversity of practices in Parliamentary Technology Assessment (PTA). The key practices in focus have been interactive in the...

  6. PACITA: volta no. 04 (Apr. 2013)

    OpenAIRE

    PACITA Consortium (Hrsg.)

    2015-01-01

    volta – Science, Technology and Society in Europe; No. 04 – April 2013PACITA (Parliaments and civil society in Technology Assessment) has been a four-year EU financed project under FP7 aimed at increasing the capacity and enhancing the institutional foundation for knowledge-based policy-making on issues involving science, technology and innovation, mainly based upon the diversity of practices in Parliamentary Technology Assessment (PTA). The key practices in focus have been interactive in the...

  7. Võistlused : [kalasport, 28. apr. - 30. juun. 2012

    Index Scriptorium Estoniae

    2012-01-01

    Kevadkalake, Töörahva Kala, Kevadsärg, Vagula Röövik, Saadjärve Haug, EMV Õngitsemises (mehed), Linnakala, Suure-Jaani Spinning, Tuulekala Trolling, Rakvere Koger, Gorodenko Spinning, EMV Õngitsemises (naised ja noored)

  8. Monthly results of measurements: Apr 2001

    International Nuclear Information System (INIS)

    This report of the OPRI (Office of Protection against Ionizing Radiations) exposes the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, fishes), sea water around nuclear sites and other sites. The activities of various radioisotopes are presented in tables

  9. From après-ski to après-tourism: the Alps in transition?

    Directory of Open Access Journals (Sweden)

    Philippe Bourdeau

    2009-12-01

    Full Text Available Winter sports occupy a prominent place in European tourism, not only because of their economic importance in mountainous areas but also due to their major symbolic significance in the "leisure civilisation". Yet the world of winter tourism is full of uncertainties connected with climate change and also with evolutions and structural breaks that call into question the development model on which it is based. This context of profound change gives us the opportunity to question the limits of the industrial model that has governed the development of the Alps for the practice of skiing and to examine alternative future scenarios to "all-out skiing" and even "all-out tourism".Les sports d’hiver occupent une place de premier plan dans le tourisme européen, non seulement du fait de leur poids économique dans les régions de montagne, mais aussi par leur forte dimension symbolique dans la « civilisation des loisirs ». Pourtant l’univers du tourisme hivernal est parcouru par de nombreuses incertitudes liées au changement climatique, mais aussi à des évolutions et des ruptures structurelles qui remettent en question le modèle de développement sur lequel il repose. Ce contexte de mutation permet d’interroger les limites du modèle industriel qui a présidé à l’aménagement des Alpes pour la pratique du ski et d’examiner des figures d’avenir alternatives au « tout ski » et même au « tout tourisme ».

  10. Les réseaux sociaux et l’échange entre l’homme politique et les internautes : le cas de Facebook après les élections présidentielles en France Social Networks and the Exchange Between Politicians and Surfers: Facebook and the presidential post elections in France

    OpenAIRE

    Galia Yanoshevsky

    2010-01-01

    A travers l’analyse des interactions entre hommes politiques et internautes sur Facebook après les élections présidentielles de 2007 en France, cet article vise à montrer comment les réseaux sociaux sont exploités par les deux parties. Au départ un réseau décentralisé qui lie les gens sans intervention politico-hiérarchique, Facebook est mobilisé par les hommes politiques au service de leur besoins. Quelles en sont les conséquences pour la sphère publique : s’agit-il d’un outil qui permet à l...

  11. Registrierung von 3D-Ultraschall mit MRT- und CT-Daten für die navigierte Chirurgie

    OpenAIRE

    Dekomien, Claudia

    2013-01-01

    Das in dieser Arbeit vorgestellte ultraschallbasierte Navigationssystemen basiert auf der Registrierung von präoperativen MRT- oder CT-Volumendaten mit dem intraoperativen 3D-Ultraschall. Für die Registrierung des intraoperativen Ultraschall mit den präoperativen Bilddaten wird ein Oberflächen-Volumen-Algorithmus verwendet. Im Rahmen dieser Arbeit wurden die in Vorarbeiten entwickelte ultraschallbasierte Registrierung wie folgt erweitert: Erweiterung auf die Registrierung von MRT-...

  12. Chirurgie de la déglutition dans le traitement d'aspirations récidivantes

    OpenAIRE

    Von Wihl, S; Bouayed, S; Kohler, Romain Pierre; Dulguerov, Pavel

    2012-01-01

    Severe dysphagia resulting in repeated aspirations and pneumonia are difficult to treat with swallowing therapy and surgical treatment is often required. Our study retrospectively reviews our experience with 19 such cases operated by laryngeal suspension and laryngotracheal separation. Restoration of oral nutrition was possible in 45% of laryngeal suspension cases and in 75% of laryngotracheal separation operations. These surgical techniques prevent severe aspirations while conserving phonati...

  13. Utilité de l'examen clinique dans la recherche de foyers infectieux avant chirurgie cardiaque

    OpenAIRE

    Lardon, Nicole; Quinodoz, Didier François; Kalangos, Afksendiyos; Dulguerov, Pavel

    2000-01-01

    In many institutions patients are evaluated to rule out an infectious focus in the ENT sphere prior to cardiac surgery. In a prospective clinical study we assessed the contribution of history and clinical examination in the detection of ENT infections.

  14. reconstruction de formes pour la chirurgie assistée par ordinateur basée sur l'enregistrement

    OpenAIRE

    Fleute, Markus

    2001-01-01

    L'objectif de cette thèse est la reconstruction de surfaces anatomiques à partir d'un nombre restreint de radiographies et de points acquis en phase per-operatoire. L'approche proposée repose sur une mise en correspondance des données avec un modèle déformable statistique afin d'incorporer de la connaissance à priori sur la forme de l'objet à reconstruire. L'élaboration d'un tel modèle statistique nécessite l'analyse de forme dans une population donnée. Pour cette analyse un modèle générique ...

  15. Mechanismen des vaskulären endothelialen Wachstumsfaktors (VEGF) in der klinischen und experimentellen Plastisch-Rekonstruktiven Chirurgie

    OpenAIRE

    Infanger, Manfred

    2010-01-01

    Vascular endothelial growth factor (VEGF) is one of the most potent mediator of vascular regulation in angiogenesis and vascular permeability. Especially in Plastic reconstructive Surgery, the impact of VEGF is important. Our data clearly document that treatment with VEGF is beneficial to the healing in vascular microsurgery. In severe burn injury, VEGF serum level is strongly enhanced and correlated with local and general tissue edema. For tissue engineering in Plastic surgery, simulated whi...

  16. Die Gefäßarchitektur der Bauchwand und ihre Stellung in der Plastischen Chirurgie : eine anatomische Untersuchung

    OpenAIRE

    Okafor, Chukwubikem Akabogu

    2008-01-01

    Background and Aim: Wound healing complications and / or necrosis of the umbilicus, due to decreased vascularisation as a result of plastic surgical interventions as in abdominoplasty or abdominal flap surgery e.g. TRAM-flaps, VRAM-flaps, DIEP-flaps and SIEA-flaps are frequent. Aim of this study is to define territories of the abdominal wall which run the risk of decreased vascularisation in order to optimise plastic surgical techniques.Methods: Twelve fresh and unfixed human corpes of either...

  17. Optimisation of radio-guided interventional procedures in vascular surgery; Optimisation des procedures interventionnelles radioguidees en chirurgie vasculaire

    Energy Technology Data Exchange (ETDEWEB)

    Sabatier, Jean [Service de chirurgie vasculaire, Clinique de l' Europe, 73 Boulevard de l' Europe, 76100 Rouen (France)

    2011-07-15

    Vascular surgery has evolved in the past twenty-five years, with the appearance of endovascular techniques which are assuming an increasingly important place in the therapeutic arsenal against peripheral vascular pathologies. These techniques require the use of an X-ray image intensifier (XRII) which exposes the medical personnel, ancillary staff and patient to ionising radiation. The most common arterial damage that can be treated by endovascular techniques concern the thoracic aorta, the abdominal aorta, the visceral arteries, the arteries to the brain, the arteries of the upper and lower limbs. These interventions take place in operating theaters in a surgical environment with the use of a mobile XRII ring and a radiation-transparent carbon surgical table. The radiation protection of the staff and the patient is in any case based, whenever possible, on the use of pulsed techniques, diaphragms, and the wearing of protective aprons and goggles. Depending on the part of the body and the damage being treated, the irradiation dose will be extremely variable. (author)

  18. Lung cancer from the perspective of internal medicine and surgery; Lungenkrebs aus Sicht der Inneren Medizin und Chirurgie

    Energy Technology Data Exchange (ETDEWEB)

    Prasse, A.; Mueller-Quernheim, J. [Universitaetsklinikum Freiburg, Abteilung fuer Pneumologie, Medizinische Klinik, Freiburg (Germany); Waller, C. [Universitaetsklinikum Freiburg, Abteilung fuer Haematologie und Onkologie, Medizinische Klinik, Freiburg (Germany); Passlick, B. [Universitaetsklinikum Freiburg, Abteilung fuer Thoraxchirurgie, Chirurgische Klinik, Freiburg (Germany)

    2010-08-15

    In previous years numerous advances in diagnostics, staging and therapy of lung cancer have been achieved. Nevertheless, it remains the most frequent cause of death from cancerous diseases. Early diagnosis and exact staging enable multimodal therapy regimens adjusted to age and comorbidities, which result in complete remission in a few and in prolonged survival and good quality of life in most patients. Curative surgery is possible in stage I non-small cell lung cancer (NSCLC) and results in a 5-year survival rates of up to approximately 75%. Using multimodal therapy approaches long-term survival can even be achieved in 40-50% of patients with advanced T4 tumors. However, in NSCLC with distant metastases median survival time is only 8-12 months. In elderly patients with no surgical options low cytotoxic monotherapy can be employed with a palliative intent. In the limited disease stage of small cell lung cancer (SCLC) long lasting remission after polychemotherapy has been observed in a minority of patients. However, in the extensive disease stage polychemotherapy prolongs the survival time of SCLC patients from 1-2 months to approximately 12 months. (orig.) [German] In den zurueckliegenden Jahren hat es bzgl. Diagnostik, Stadieneinteilung und Therapie des Lungenkarzinoms einige Fortschritte gegeben. Dennoch ist es weiterhin die haeufigste Todesursache durch Krebserkrankungen. Eine zuegige Diagnostik, gefolgt von einer exakten Stadieneinteilung, erlauben multimodale Therapieansaetze, die an Lebensalter und Komorbiditaeten angepasst werden koennen. Kurative Operationen sind im Stadium I des nichtkleinzelligen Lungenkarzinoms (NSCLC) moeglich und fuehren zu einem 5-Jahres-Ueberleben von bis zu 75% aber auch bei fortgeschrittenen T4-Tumoren kann durch eine multimodale Therapie noch ein Langzeitueberleben von 40-50% erreicht werden. Beim nichtkleinzelligen Lungenkarzinom mit Fernmetastasen betraegt die mediane Ueberlebenszeit jedoch nur noch 8-12 Monate. Insgesamt fuehren die aktuell verfuegbaren multimodalen Therapien bei den meisten Patienten zu einer Lebensverlaengerung mit guter Lebensqualitaet. Zur Palliation kommen bei inoperablen Patienten in hohem Alter Monochemotherapien mit nur geringer Toxizitaet zum Einsatz. Beim kleinzelligem Lungenkarzinom im Stadium ''limited disease'' werden gelegentlich langfristige Remission nach Polychemotherapie beobachtet. Im Stadium ''extensive disease'' verlaengert diese die Lebenserwartung von 1-2 auf etwa 12 Monate. (orig.)

  19. Les réseaux sociaux et l’échange entre l’homme politique et les internautes : le cas de Facebook après les élections présidentielles en France Social Networks and the Exchange Between Politicians and Surfers: Facebook and the presidential post elections in France

    Directory of Open Access Journals (Sweden)

    Galia Yanoshevsky

    2010-10-01

    Full Text Available A travers l’analyse des interactions entre hommes politiques et internautes sur Facebook après les élections présidentielles de 2007 en France, cet article vise à montrer comment les réseaux sociaux sont exploités par les deux parties. Au départ un réseau décentralisé qui lie les gens sans intervention politico-hiérarchique, Facebook est mobilisé par les hommes politiques au service de leur besoins. Quelles en sont les conséquences pour la sphère publique : s’agit-il d’un outil qui permet à l’internaute de déjouer les usages de marketing politique qu’en fait l’homme politique ?The purpose of this article is to show how social networks, and more specifically Facebook, are used by politicians and their supporters. This is achieved through a detailed analysis of exchange of posts between politicians and surfers in the period following the presidential election campaigns in France of 2007. It is shown how politicians take advantage of Facebook, despite its initially being a decentralized social network, connecting people without a political or hierarchic purpose. The article attempts to show some of the consequences of such an exploitation of a public network for the public sphere and asks how much leverage there is for the surfers/citizens in moderating political marketing on Facebook.

  20. Conservation et disparition des repères de crue – Exemple des repères apposés après la crue de 1930 en Lot-et-Garonne et dans le sud du Tarn

    Directory of Open Access Journals (Sweden)

    François Gazelle

    2009-04-01

    Full Text Available Pour matérialiser les niveaux atteints par les crues importantes en des points significatifs, et pour en conserver la mémoire à toutes fins utiles, la loi BACHELOT de juillet 2003 fait obligation aux mairies ou services d'État de mettre en place des repères visibles, pratique qui n'est pas nouvelle mais qui tendait à s'estomper d'autant qu'elle n'était pas réglementaire. On peut s'interroger sur la conservation de ces repères au fil des décennies. À ce titre, les auteurs ont exploité les données archivistiques et effectué des enquêtes de terrain pour appréhender la présence ou l'absence de repères placés après la crue de 1930 en deux secteurs du Sud-Ouest de la France, et saisir les causes des disparitions recensées.In order to show the levels reached by major flood events at significant points, and in order to record the information for future reference, the law promoted by BACHELOT in July 2003 places an obligation on municipal councils and state-run bodies to put in place visible markers, a practice which is not new but which had tended to die out while it was not a statutory requirement. It is reasonable to raise the question of the conservation of these markers over the decades. With this in mind, the authors made use of archival data and carried out field investigations in order to determine the presence or absence of markers put in place after the flood of 1930 in two areas of south-western France, and to establish the causes of the disappearances that they found.

  1. Chernobyl, 16 years later; Tchernobyl, 16 ans apres

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-04-01

    This document on the Chernobyl site evolution is constituted around four main questions. What about the future of the Chernobyl site, the damaged reactor and the ''sarcophagus'' constructed around the reactor? What about the sanitary consequences of the accident on the liquidators asked to blot out the radiation and the around people exposed to radiation? What about the contaminated land around the power plant and their management? Concerning the France, what were the ''radioactive cloud'' sanitary consequences? (A.L.B.)

  2. Chernobyl, after the apocalypse; Tchernobyl, apres l'apocalypse

    Energy Technology Data Exchange (ETDEWEB)

    Coumarianos, Ph

    2000-07-01

    This document recalls the human aspects of the Tchernobyl reactor accident threw a series of testimonies, from the power plant head and engineers, to the firemen and people from the surrounding population. (J.S.)

  3. Acid Rain Data at Yokohama, Japan (Apr. 2003-Aug. 2004)

    OpenAIRE

    Murayama, Haruta

    2005-01-01

    Rain samples were collected adequately at the center of Yokohama city from April 2003 to August 2004. Total numbers of samples were 214. pH values and electric conductivity (E.G.) were measured immediately after catched samples and then chemical species were analyzed. This report is contained all observed data. Frequency of acid rain(pH

  4. L'OPTIQUE QUANTIQUE ATOMIQUE : APRES LES BOSONS, LES FERMIONS

    OpenAIRE

    Westbrook, Christoph I; Aspect, Alain; Boiron, Denis

    2007-01-01

    Les avancées de l'optique atomique permettent de plus en plus de rapprochements avec l'optique traditionnelle ; les expériences fondatrices de corrélation de photons en optique quantique ont trouvé leurs analogues atomiques. L'observation récente du groupement et dégroupement d'atomes ouvre des perspectives sur des observations de systèmes fortement corrélés d'un grand nombre de particules.

  5. Thyroid tumors after irradiation; Tumeurs de la thyroide apres irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Schlumberger, M. [Centre de Lutte Contre le Cancer Gustave-Roussy, 94 - Villejuif (France)

    1995-12-31

    Epidemiological studies have shown an increased incidence of thyroid tumors after external irradiation during childhood. These studies have shown a long latency and have pointed out risk factors, related either to the subject (young age, female sex) or to the radiation (dose, fractionation, protection). Irradiation by Iodine 131 in adulthood does not seen to increase the risk of thyroid tumor but in childhood data are too scarce to allow any conclusion. Similarly, the risks following low radiation doses and/or protected radiation exposure are still matter of debate. (author). 41 refs., 5 tabs., 1 fig.

  6. Chernobyl, 12 years later; Tchernobyl, douze ans apres

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-01

    This report draws an account of the consequences of Chernobyl accident 12 years after the disaster. It is made up of 7 chapters whose titles are: (1) Some figures about Chernobyl accident, (2) The Chernobyl nuclear power plant, (3) Sanitary consequences of Chernobyl accident, (4) The management of contaminated lands, (5) The impact in France of Chernobyl fallout, (6) The Franco-German cooperation, and (7) Glossary.

  7. Chernobyl, 14 years later; Tchernobyl, 14 ans apres

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    This report draws an account of the consequences of Chernobyl accident 14 years after the disaster. It is made up of 8 chapters whose titles are: (1) Some figures about Chernobyl accident, (2) Chernobyl nuclear power plant, (3)Sanitary consequences of Chernobyl accident, (4) The management of contaminated lands, (5) The impact in France of Chernobyl fallout, (6) International cooperation, (7) More information about Chernobyl and (8) Glossary.

  8. Chernobyl, 13 years after; Tchernobyl, 13 ans apres

    Energy Technology Data Exchange (ETDEWEB)

    Regniault-Lacharme, Mireille; Metivier, Henri [Inst. de Protection et de Surete Nucleaire, CEA Centre d' Etudes de Fontenay-aux-Roses, 92 (France)

    1999-04-01

    This is an annual report, regularly issued by IPSN, that presents the ecological and health consequences of the Chernobyl Nuclear Accident. The present status of the Chernobyl Nuclear Plant, which Ukraine engaged to stop definitively in year 2000, is summarized. The only reactor unit now in operation is Chernobylsk-3 Reactor which poses two safety questions: evolution of cracks in part of the tubing and behaviour of the pressure tubes. Although, some improvements in the RBMK reactor types were introduced, problems remain that make IPSN to stress the requirement of stopping this NPP completely. In the contaminated territories surrounding Chernobyl incidence rate of infant thyroid cancers continues to grow, reaching values 10 to 100 times higher than the natural rate. In France the IPSN analyzed 60,000 records carried out in 17 sites during May 1986 and April 1989. It was estimated that the individual dose received during 60 years (1986-2046) by the inhabitants of the most affected zone (eastern France) is lower than 1.5 mSv, a value lower than 1% of the natural cosmic and telluric radioactivity exposure for the same period. For the persons assumed to live in the most attacked forests (from eastern France) and nourishing daily with venison and mushrooms the highest estimate is 1 mSv a year. Concerning the 'hot spots', identified in mountains by IPSN and CRIIRAD, the doses received by excursionists are around 0.015 mSv. For an average inhabitant of the country the dose piled up in the thyroid due to iodine-131 fallout is estimated to 0.5-2 mSv for an adult and 6.5-16 mSv for an infant. These doses are 100 to 1000 times lower than the ones to which the infants living in the neighbourhood of Chernobyl are exposed to. The contents of the report is displayed in the following six chapters: 1. Chernobyl in some figures; 2. The 'sarcophagus' and the reactors of the Chernobyl NPP; 3. Health consequences of the Chernobyl accident;. 4. The impact of Chernobyl fallout in France; 5. Chernobyl's environment and the management of contaminated territories.; 6. The French-German initiative for Chernobyl.

  9. Extended Station Blackout Coping Capabilities of APR1400

    OpenAIRE

    Sang-Won Lee; Tae Hyub Hong; Mi-Ro Seo; Young-Seung Lee; Hyeong-Taek Kim

    2014-01-01

    The Fukushima Dai-ichi nuclear power plant accident shows that an extreme natural disaster can prevent the proper restoration of electric power for several days, so-called extended SBO. In Korea, the government and industry performed comprehensive special safety inspections on all domestic nuclear power plants against beyond design bases external events. One of the safety improvement action items related to the extended SBO is installation of external water injection provision and equipment t...

  10. Market Review RE Market Apr.10~20

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ RE carbonate in Baotou was in tight supply due to the strong demand.Prices of Nd and Pr products kept on rising recently.Affected by the price rising of SmEuGd concentrate in Baotou,price of europium went upward.

  11. Le facteur soudanais, avant et après

    OpenAIRE

    Marchal, Roland

    2002-01-01

    Le 11 septembre 2001 reposait la question de la nature du régime soudanais et des étranges amitiés qu’il a cultivées depuis son arrivée au pouvoir, le 30 juin 1989. En effet, les États occidentaux savaient que le chef d’Al- Qaida, Oussama Ben Laden, avait longtemps résidé au Soudan – de 1991 à 1996 – parmi bien d’autres militants fondamentalistes, et que les liens avec les courants les plus durs de l’islamisme s’étaient poursuivis. De nombreux observateurs auguraient alors une forte réacti...

  12. Zorn: Avant/Après/Passé

    Directory of Open Access Journals (Sweden)

    John Lowell Brackett

    2012-06-01

    Full Text Available Witold Wachowski’s brief exchange with John Zorn provides us with many valuable insights relating to the composer’s aesthetic. Zorn’s professed antipathy towards audiences, his faith in the creative instinct of the “artist,” and his belief in the transcendental nature of musical works (as a gateway into a world of “truth” and “beauty” are all refrains commonly encountered in many interviews with the composer. Given the fact that Zorn emphasizes these themes in his very short interview with Wachowski, we can assume that these ideas form the core of Zorn’s musical and artistic aesthetic. For any person with even a basic knowledge of Western aesthetic traditions, however, these same aesthetic features and positions characterize musical institutions common to the Western art tradition, particularly the “romantic” ideal of music and composers that developed in the nineteenth century. Philosophers (most notably Hegel and Kant along with music critics and composers (such as Friedrich Schiller, E.T.A. Hoffmann, Friedrich Schlegel, Robert Schumann, and Eduard Hanslick all contributed to the development of a romantic musical aesthetic in the nineteenth century that emphasized the role of the artist (as a “genius” or “god-like” who created “works” that – through purely musical relations that exist irregardless of the listener’s abilities – reveal hidden worlds of truth and beauty, worlds far-removed from the humdrum concerns of daily existence. Given the close (nearly one-to-one correspondences between Zorn and aestheticians/philosophers of the nineteenth century, one could make the argument that Zorn holds a “romantic” view of music and art.

  13. Chernobyl, fifteen years after; Tchernobyl, 15 ans apres

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-04-01

    This work has been constituted around four questions: the future of the Chernobyl site, the damaged reactor, and the sarcophagus around it; the health consequences of the accident on the persons that have worked on the damaged reactor and on the population in the countries the most exposed to fallout,; the situation of contaminated territories around the power plant and their management today; the last question concerns especially the France with the consequences of the radioactive cloud and what we know about the health risks induced by this event. (N.C.)

  14. ABSTRACTS( Vol. 26 No. 2 Apr. 2012)

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Fa Lin, Wang Lei, Zheng Yajuan, Zhang Qi and Zhang Xiaohu. The application of acoustics in oil logging and geophysical exploration. PI. 2012,26 (2): 1-6 By using the method of acoustic-electric analogue, this paper sets up the equivalent circuits of acoustic transducer, and gives the relationship between the acoustic-signal radiated by the source-transducer and the driving-voltage signal and that between the acoustic-signal and electric-signal converted from the receiver-transducer. This paper employs the convolution of the driving-voltage signal with the electric-acoustic impulse response of the source-transducer to replace some assumed acoustic-source functions adopted in previouly published literature on acoustic logging, such as Tsang wavelet and so on. In this paper the concept and theory of signal transmission is used to analyze the total acoustic- logging process, and the acoustic-logging transmission network model is set up. This model sets up the theoretical basis for accurate measurements of propagation speed, phase, amplitude and frequency information of acoustic-logging signal. The development of a new device, Kaiser in-situ stress system is introduced. This device is designed to measure in-situ stresses via detected acoustic emissions caused by the Kaiser effect in rocks. The system provides a technical means for both the economic and efficient evaluation of the three principal stresses in rocks. This is useful to assess the in-situ stress field in oil and gas reservoirs and to predict natural geology hazard. A new algorithm of inversion oil reservoir by using logging data and seismic exploration date is also described.

  15. Two years after the storms; 2 ans apres les tempetes

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-12-01

    This document takes stock on the power distribution repair, two years after the storms of december 1999 in France. It also presents the new organization (FIRE) developed to face such natural or accidental disasters. (A.L.B.)

  16. La politique française à l’égard de l’émigration juive polonaise de l’immédiat après-guerre French policy towards the Exodus of Polish Jews in the Aftermath of World War II

    Directory of Open Access Journals (Sweden)

    Julia Maspero

    2012-03-01

    Full Text Available Cet article traite de la politique française à l’égard de l’émigration juive polonaise de l’immédiat après-guerre. Cette politique se définit en France et dans les zones françaises d’occupation en Allemagne et en Autriche. Comme le montre l’existence d’une catégorie « DP juifs » dans les recensements ainsi que la mise en place de camps DP juifs et de kibboutzim, les autorités françaises considéraient les réfugiés juifs de l’Est comme un groupe à part. Cet article montre le rôle important, pour atteindre la France et l’Italie puis la Palestine, joué par les zones françaises d’occupation de part leur position géographique cruciale (relations diplomatiques avec les Américains et Italiens, politique de refoulement…. La France a quant à elle été pour ces réfugiés bien plus un pays de transit vers les Amériques et la Palestine qu’un pays d’accueil, comme on peut le constater à travers les tentatives de contrôle des flux : mise en place d’un accord sur l’admission en transit de 8 000 réfugiés juifs de Pologne (conditions de l’accord, position des différents ministères français et des organisations juives en France… et refoulement vers l’Allemagne.This article is about the French policy towards Polish Jews emigration in the aftermath of WWII. This policy has been defined in France and in French zones of occupation in Germany and Austria. As shown by the existence of a “Jewish DPs” category in the census and the setting up of Jewish DP camps and kibbutzim, French authorities considered Jewish refugees from Eastern Europe as a separate group. This article shows the important role played by the French zones in the path followed by Jewish refugees in order to reach France and Italy and then Palestine (diplomatic relations with Americans and Italians, the policy of expulsion. It also shows that France has been for these refugees more a transit country to Americas and Palestine than

  17. Aspects architecturaux de la transformation de Hà Nội après le Đổi mới (1986 : contradictions, phantasmes, espoirs Architectural Aspects of Hà Nội’s Transformation after Đổi mới (1986: Contradictions, Fantasies, Hopes

    Directory of Open Access Journals (Sweden)

    Heinz Schütte

    2009-06-01

    Full Text Available Depuis le Đổi mới, c’est-à-dire depuis la progressive libéralisation de l’économie vietnamienne, Hà Nội a connu de profondes mutations. Après des décennies de guerres et l’échec de la mise en place d’un système économique socialiste, des changements radicaux se sont opérés dans le paysage urbain de Hà Nội. Ces modifications sont visibles dans le bâti urbain pour tout visiteur de la ville. Cet article tente de montrer que, contrairement aux apparences, ce processus de transformation n’est ni aléatoire ni chaotique, mais qu’il suit une logique historique et culturelle, et qu’il ne peut être réduit à un phénomène de globalisation. Les riches villas du Lac de l’Ouest sont représentatives des valeurs d’une nouvelle classe sociale qui a émergé suite au Đổi mới. Les mutations architecturales de la ville reflètent les changements sociaux : la ville tend à devenir un lieu de consommation alors que les riches villas se bâtissent à sa périphérie, bouleversant ainsi l’organisation de l’espace traditionnel.Ever since Đổi mới, the arrival of capitalist market forms, and the evolution of corresponding social relations, Hà Nội has undergone a dramatic upheaval. After revolutions, wars and the failure of centralized economy, we are currently witnessing a radical change from pre-modernity to the modernity of a globalized age. The consequences are perceptible when strolling through Hà Nội’s streets and talking to the capital’s inhabitants. This article attempts to demonstrate that the process of transformation is not as random or chaotic, as it may seem, but that it follows a logic that can be historically categorized. The posh new villas on West Lake and their upwardly mobile owners represent new, syncretic values; the origins of family businesses are carefully hidden; the individual activities in the 36 guild streets of the Old Quarter; these are all testaments to change that

  18. La trochantérite tuberculeuse, un diagnostic souvent difficile

    Science.gov (United States)

    Mhammdi, Younes; Boufettal, Moncef; Kharmaz, Mohamed; Lahlou, Abdou; Mahfoud, Mustapha; EL Bardouni, Ahmed; Berrada, Mohamed Saleh

    2016-01-01

    La trochantérite tuberculeuse est une affection rare (<2% des tuberculoses ostéo-articulaires), même en pays à forte endémie, elle est caractérisée par une symptomatologie insidieuse rendant souvent son diagnostic tardif. Les auteurs rapportent une série de 9 cas, le diagnostic a été posé sur des études bactériologiques et histologiques après un bilan d'imagerie (échographie, IRM, TDM). Le traitement de cette affection est médical (antibiothérapie antituberculeuse), et la chirurgie ne trouve sa place qu'en cas de complications et permet d'améliorer l’évolution. PMID:27279938

  19. L’itinéraire d’un chirurgien nord-vietnamien : Entre révolution nationale et science internationale

    OpenAIRE

    Aso, Michitake; Guénel, Annick

    2015-01-01

    Formé à l’École française, le chirurgien vietnamien Tôn Thất Tùng rejoint le Viêt Minh dès le début de la guerre d’Indochine, et met ses compétences au service de la résistance. Après 1954, il participe à la reconstruction sanitaire de la République démocratique du Viêt Nam. En retour de ses services, l’État lui offre la possibilité de reprendre ses travaux sur la chirurgie hépatique, commencés sous la colonisation. La mise au point d’une technique nouvelle lui permet de publier dans des jour...

  20. Epidemiological analysis on virus etiology of acute respiratory infection during Oct 2010 and Apr 2011 in Beijing%北京地区2010年10月至2011年4月急性呼吸道感染病毒流行特征分析

    Institute of Scientific and Technical Information of China (English)

    黄芳; 石伟先; 崔淑娟; 钱海坤; Yan Li; 邓瑛

    2011-01-01

    spectrum were influenza A virus, respiratory syncytial virus and adenovirus. The positive ratio for the virus detection was distributed timely. It was high from Oct to Apr of next year and it as maximum in Nov (93.75%) while it was dropped down from Mar. The dominated viruses were different in different months and in different age groups. For the 0 ~ 5 age groups, the respiratory syncytial virus was maximum and for 5 ~ 15 age group adenovirus was found largest while for all the other age groups more than 15 years old influenza A was the dominated virus. Conclusions Influenza virus, respiratory syncytial virus, adenovirus were the main pathogens leading to acute respiratory infection during winter and spring in Beijing and the pathogens have specific epidemiology according to the ages and months.

  1. Aplikace marketingu na klinice plastické chirurgie v Českých Budějovicích

    OpenAIRE

    MAŘÍKOVÁ, Lucie

    2010-01-01

    The aim of the thesis is to found out what are the specifics of aplication marketing in plastic surgery, describe target group of clients and esamine which are the most widely used marketing tools in plastic surgery.

  2. Place of surgery in high-risk tumours of the prostate; Place de la chirurgie dans les tumeurs de la prostate a haut risque

    Energy Technology Data Exchange (ETDEWEB)

    Soulie, M. [Service d' urologie, d' andrologie et de transplantation renale, hopital de Rangueil, CHU de Toulouse, 31 - Toulouse (France); Universite Paul-Sabatier, 31 - Toulouse (France); Rozet, F. [Service d' urologie, institut Montsouris, 75 - Paris (France); Universite Descartes-Paris 5, 75 - Paris (France); Hennequin, C. [Service de radiotherapie, hopital Saint-Louis, 75 - Paris (France); Universite Paris-Diderot Paris-7, 75 - Paris (France); Salomon, L. [Service d' urologie, hopital Henri-Mondor, 94 - Creteil (France); Universite Paris-Est Creteil Val-de-Marne, 94 - Creteil (France)

    2010-10-15

    Among the different options recommended for high-risk prostate cancer, radical prostatectomy is admitted as radiotherapy, but its role is still controversial in mono-therapy and difficult to evaluate in combined treatments. The results of clinical trials combining an external radiotherapy to a long-term androgen deprivation in locally advanced tumours sustain the principle of a multidisciplinary management in high-risk prostate cancer. The impact of surgery on the risk of progression and local recurrence is important in selected patients with low grade and small tumoral volume. Clinical and histological data associated to the MRI assessment remain essential and enhance the preoperative multidisciplinary decision, especially regarding nodal and distant metastases. Radical prostatectomy with an extended pelvic lymphadenectomy can be considered as a viable alternative to radiotherapy and hormonal therapy in these patients with a long life expectancy but presenting a high risk of local progression and a low risk of metastatic disease. Morbidity of the procedure is similar to radical prostatectomy for organ-confined tumours despite more erectile dysfunction due to non-sparing radical prostatectomy in most of cases. Oncological results from recent compiled series show 10- and 15-year specific survival rates around 85 and 75%, respectively, including adjuvant or salvage treatments with radiotherapy, androgen deprivation or chemotherapy. (authors)

  3. Korrelation der bioelektrischen Impedanz-Analyse (BIA) und Lebensqualität nach körperformenden Eingriffen in der Plastischen Chirurgie

    OpenAIRE

    Smeets, Ralf

    2003-01-01

    Introduction: In plastic surgery, body contouring becomes more popular. In this study, long-term effects of abdominoplasty and liposuction on fat-/BMI-values and changes in quality of life were analysed. Materials and methods: The study included two patient groups who underwent plastic surgery between October 1998 and November 2001. 57 patients (group A) underwent liposuction, 41 (group B) abdominoplasty. Fat and BMI-values were determined one hour before surgery, at the first postoperative d...

  4. Chirurgie virtuelle : modélisation temps réel des tissus mous, interactions et système haptique dédié

    OpenAIRE

    Chendeb, Safwan

    2007-01-01

    The medical field is emerging recently some pedagogic simulators like what it exists from several years in other field like flight simulator or car driving simulator. Indeed, the current training of surgeons is performed on corpses (difficult, expensive and not practical) and companionship (with experienced surgeons). These difficulties involve a growing demand for surgical pedagogic simulators, especially in the field of mini-invasive surgery, with a consideration of gestures and tactile sen...

  5. Entwicklung eines verfahrens zur Herstellung eines rein autologen Fibrinklebers und dessen Anwendung im Tissue Engineering von Knorpelgewebe für die plastisch-rekonstruktive Chirurgie

    OpenAIRE

    Loch, Alexander

    2010-01-01

    Methods of tissue engineering combine cells and biomaterials to grow regenerative tissue. Because of its excellent biocompatibility fibrin has become a frequently used matrix in tissue engineering. To date, autologous fibrinogen has usually been polymerised with bovine thrombin. Bovine thrombin, however can cause severe immunological side effects and in some cases patients even died after recurrent use. The objective of this study was to explore the practicability of obtaining autologous thro...

  6. Mikrochirurgische Rekonstruktionsverfahren in der MKG-Chirurgie: Indikationen, Ergebnisse und Risikofaktoren untersucht anhand einer retrospektiven Analyse des Zeitraumes 1998-2003 unter Verwendung einer neu implementierten Datenbank

    OpenAIRE

    Leitner, Christoph

    2007-01-01

    Einleitung: Wenngleich in den letzten drei Jahrzehnten keine wesentlichen Fortschritte hinsichtlich der Überlebenszeit von Patienten mit bösartigen Kopf-Halstumoren erreicht werden konnten, haben mikrochirurgische Gewebetransplantationen in den letzten 15 Jahren die Möglichkeiten der Rekonstruktion großer im Rahmen operativer Tumorbehandlungen entstehender Weichteil- und Knochendefekte im Mund-, Kiefer- und Gesichtsbereich revolutioniert, mit deren Hilfe eine defektadäquate Versorgung und so...

  7. Akustisch evozierte Hirnstammpotentiale bei Hunden zur Untersuchung der primär sekretorischen Otitis media im Rahmen der laserassistierten Chirurgie des Brachyzephalen Syndroms

    OpenAIRE

    Truar, Katrin

    2015-01-01

    Durch die höhere Verfügbarkeit von Schnittbildverfahren in der Kleintiermedizin treten Flüssigkeitsansammlungen in der Bulla tympanica immer häufiger als Zufallsbefund bei Hunden, insbesondere bei brachyzephalen Rassen, auf. Aufgrund der fehlenden klinischen Symptome der Patienten ist eine akute Entzündung unwahrscheinlich. Daher bezeichnen neuere Studien diese Flüssigkeitsansammlung als primär sekretorische Otitis media (PSOM). In der vorliegenden Studie wurde untersucht, ob Hunde der Ras...

  8. Apprentissage de la chirurgie orthopédique assisté par ordinateur : Le cas du Système Tutoriel Intelligent TELEOS

    OpenAIRE

    Toussaint, Ben-Manson; Luengo, Vanda; Vadcard, Lucile; Tonetti, Jérôme

    2014-01-01

    El objeto de la investigación presentada en este artículo es el diseño de Entorno Informático de Aprendizaje Humano. El caso estudiado es el Sistema Tutorial Inteligente TELEOS (Technology Enhanced Learning Environment for Orthopaedic Surgery) que apoya al aprendizaje de la cirugía ortopédica percutánea, más precisamente, vertebroplastia y atornillamiento sacroilíaco. El artículo resume el conjunto de los trabajos de investigación que forma la base del desarrollo de este sistema, sus funciona...

  9. COMENTARIU LA ARTICOLUL FISTULE CHOLÉCYSTO - DUODÉNALE E. Christide - Revista de Chirurgie 1938; 7 - 8/41: 579 - 585

    OpenAIRE

    Nicolae M. Constantinescu

    2012-01-01

    Prezenţa unei fistule colecisto-duodenale este încă şi astăzi de cele maimulte ori o descoperire intraoperatorie. Deşifrecvenţa acestei complicaţii a bolii litiaziceeste relativ redusă (în jur de 2% dupăGlenn[1]ea ar trebui să beneficieze de undiagnostic preoperator mai mare decât celactualcare nu depăşeşte 1/6 bolnavi [2], şiaceasta datorită mortalităţii postoperatorii de15-22%, mult superioară celei înregistrateînabsenţa acestei complicaţii [2]. Preoperatorindicii importante ne sunt date de...

  10. Chronic effects of JP-8 jet-fuel exposure on the lungs. Annual report, 1 Apr 91-1 Apr 92

    Energy Technology Data Exchange (ETDEWEB)

    Witten, M.L.

    1992-04-23

    This research has resulted in four separate projects. The first was the exposure of Fischer 344 rats to JP-8 jet fuel for 7 or 28 days. This exposure resulted in changes in pulmonary function and lung chemical mediators, specifically Substance P, after 28 days of exposure. The second project dealt with blocking the increase in SP in these rats by a pretreatment regimen with capsaicin before jet fuel exposure. Capsaicin caused a further increase in lung permeability and a million-fold increase in airway sensitivity to histamine after the 7-day jet fuel exposure. The third project dealt with the effects of a 7-day jet fuel exposure in congenic mice who are deficient in the inducibility of the aryl hydrocarbon hydroxylase enzyme. These mice are relatively resistant to the effects of jet fuel-induced lung injury. The fourth project investigated the effects of the jet fuel exposure on secondary organs, specifically the liver, spleen, and kidneys. There were pathological differences in the liver, spleen, and kidneys between the 7-day jet fuel exposure group and baseline controls. However, some of these differences were not apparent in the 28-day exposure group, possibly indicating compensatory mechanisms to the exposure.

  11. De l’après-ski à l’après-tourisme, une figure de transition pour les Alpes ?

    Directory of Open Access Journals (Sweden)

    Philippe Bourdeau

    2009-12-01

    Full Text Available Les sports d’hiver occupent une place de premier plan dans le tourisme européen, non seulement du fait de leur poids économique dans les régions de montagne, mais aussi par leur forte dimension symbolique dans la « civilisation des loisirs ». Pourtant l’univers du tourisme hivernal est parcouru par de nombreuses incertitudes liées au changement climatique, mais aussi à des évolutions et des ruptures structurelles qui remettent en question le modèle de développement sur lequel il repose. Ce contexte de mutation permet d’interroger les limites du modèle industriel qui a présidé à l’aménagement des Alpes pour la pratique du ski et d’examiner des figures d’avenir alternatives au « tout ski » et même au « tout tourisme ».Winter sports occupy a prominent place in European tourism, not only because of their economic importance in mountainous areas but also due to their major symbolic significance in the "leisure civilisation". Yet the world of winter tourism is full of uncertainties connected with climate change and also with evolutions and structural breaks that call into question the development model on which it is based. This context of profound change gives us the opportunity to question the limits of the industrial model that has governed the development of the Alps for the practice of skiing and to examine alternative future scenarios to "all-out skiing" and even "all-out tourism".

  12. Oncoplastie avec conservation mammaire dans le traitement du cancer du sein: à propos de 16 cas

    Science.gov (United States)

    Bouzoubaa, Wail; Laadioui, Meryam; Jayi, Sofia; Alaoui, Fatime Zahra Fdili; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Moulay Abdelilah

    2015-01-01

    Le cancer du sein est actuellement le cancer le plus fréquent chez la femme, et pose un véritable problème diagnostique et thérapeutique. Le dépistage des lésions à un stade de plus en plus précoce, a permis une extension des indications du traitement conservateur radiochirurgical, qui était initialement limitées aux tumeurs de moins de 3 cm, unifocales, non inflammatoires. Par ailleurs, l'utilisation de traitements préopératoires permet d’étendre les indications du traitement conservateur à des tumeurs plus volumineuses. Parallèlement à cette extension des indications de conservation mammaire, on a observé le développement de nouvelles approches thérapeutiques notamment la chirurgie oncoplastique, technique du ganglion sentinelle et chirurgie stéréotaxique, dont les résultats initiaux sont très encouragent. A travers cette étude réalisée dans le service de gynécologie et obstétrique II du CHU HASSAN II de FES au MAROC, après l'analyse rétrospective de 16 patientes traitées par traitement conservateur et oncoplastie, nous avons voulus montrer notre aptitude a réalisé ses techniques chirurgicales et a bien prendre en charge ces patientes, mais aussi évaluer ces techniques en termes de résultat carcinologique et de résultat esthétique, aussi en terme de survie globale, survie sans métastase et en termes de récidive locale entre les plasties mammaires et les traitements usuels: mastectomie et traitement conservateur classique. PMID:26430477

  13. IAEA Newsbriefs. V. 9, no. 2(64). Apr-May 1994

    International Nuclear Information System (INIS)

    This issue gives brief information on the following topics: IAEA Board of Governor's Meetings in Early June, Nuclear Safety Convention, Monitoring and Verification in Iraq, Nuclear Power Regulation in China, Scientific Award for Marine Environment Programme, Assessing Radioactivity Levels at Sea, Safety at Chernobyl, An 'Energy-Ecology Dilemma', Safeguards at Nuclear Fuel Plant, Uranium Resources, Production, and Demand, Radioactive Waste Management, Global Climate Change Studies, Isotopes in Hydrology, Conference on Nuclear Power Option, Nuclear Fusion Research, Nuclear Techniques in Soil/Plant Studies, International Conference on Radiation and Society: Comprehending Radiation Risk, Experimental Fusion Reactor, Middle East NWFZ Concept Discussed, Symbolic Sculpture from South Africa, Update on Nuclear Electricity, and other short information

  14. Quarterly report of Ibaraki environmental radiation monitoring, Apr-Jun 2000

    International Nuclear Information System (INIS)

    The measurement results of space gamma dose rate at the monitoring stations and points showed less than the upper limit of variability width determined by the data monitoring committees The radioactivity in the atmosphere was not detected in the air dust, fall out and rainwater. 131I in the milk (raw milk) was not detected. The results of measurement of radioactivity in the off gas of nuclear installation by the radionuclide analysis and total beta activity measurement showed the same or less than the past data. Total alpha activity was not detected. The radioactivity measurement results in the waste of the nuclear installation by the radionuclide analysis and the total beta activity measurement was less than the reference dose determined by the data monitoring committees. The total gamma activity was not detected or the same level as the past one. (S.Y.)

  15. Quarterly report of Ibaraki environmental radiation monitoring, Apr-Jun 1999

    International Nuclear Information System (INIS)

    An environmental radiation monitoring was carried out from April to June 1999. The space gamma dose rates in the monitoring stations and posts were less than the upper limit of wide of variability determined by the data monitoring committees The radioactivity in the air dust, fall out and rainwater was not detected. 131I in milk (raw milk) and 3H in seawater were not detected. The radioactivity of off-gas of nuclear installation was not detected or less than the past level by the radionuclide analysis and total beta activity measurement. Moreover, the results of total alpha and gamma activity were not detected or the same level as the past values. (S.Y.)

  16. IAEA Newsbriefs. V. 12, no. 2(75). Apr-May 1997

    International Nuclear Information System (INIS)

    This issue gives brief information on the following topics: IAEA safeguards inspectorate granted broader rights, Conferences on nuclear liability, waste safety in early September, States set nuclear safety review meeting, Statements of IAEA Director General, Namibia joins anti-trafficking programme, Symposium on desalination in Republic of Korea, Energy issues on agenda of nuclear fuel cycle symposium in June, IAEA seminars and symposia this autumn, Recent IAEA publications, Atoms for animal health and productivity, Studying the past to learn about the future, Nuclear power status around the world, and other short information

  17. Structure de la croute terrestre en Algerie d'après les ondes sisiuiques

    Directory of Open Access Journals (Sweden)

    M. BOCKEL

    1972-06-01

    Full Text Available It has been tried to exploit in the best ways all data of
    the algerian shocks till 1969 using the various documents and publications
    found in the Seismological Center of Algiers. Various methods used for the
    near shocks ( < 700 km first and for the farther events later, show that:
    — The velocities are: Pg = 5,55 km/s, Sg = 3,22 km/s, Pn = 7,77 km/s,
    Sn = 4,32 km/s at least for the smaller distances; these velocities, relatively
    little, become greater for distances above 800 km, which means certainly
    a great increase of velocity in the upper mantle.
    — There is no significant variations of velocity between the regions
    of Algiers and Sótif.
    — The algerian shocks are shallow: most of them have a depth less
    than 15 km.

  18. Symposium on Electromagnetic Launcher Technology, 5th, Sandestin, FL, Apr. 3-5, 1990, Proceedings

    Science.gov (United States)

    Gooden, Clarence E.

    1991-01-01

    The present conference on electromagnetic accelerators (EMAs) and railguns (RGs) discusses active-current management for four-rail RGs, the design of a compulsator-drive 60-caliber RG, EMA studies with augmented rails, muzzle-shunt augmentation of conventional RGs, effect of in-bore gas on RG performance, the distributed-energy store RG, plasma diagnostics for high power ignitron development, a review of EMA armature research, RG hybrid armatures, a new solid-armature design concept, and the electrodynamics of RG plasma armatures. Also discussed is RG modeling at speed using three-dimensional finite elements, power supply technology for EMAs, rotating machine power supplies for next-generation EMAs, advanced EMA power supplies with magnetic-flux compression, metal-to-metal switches for large currents, lightweight high-effiency energy-storage transformers, hypervelocity projectile development for EMAs, structural design issues for EMA projectiles, stiff RGs, a reinforced Al conductor for cryogenic applications, mass-stabilized projectile designs for EMA launch, indictively-commutated coilguns, an actively switched pulsed induction accelerator, a plasma gun-augmented electrothermal accelerator, a symmetrical rail accelerator, and a travelling-wave synchronous coil gun.

  19. Underground coal gasification (citations from the Engineering Index Data Base). Report for 1970-Apr 80

    Energy Technology Data Exchange (ETDEWEB)

    Cavagnaro, D.M.

    1980-05-01

    The bibliography presents worldwide research pertaining to underground (in-situ) coal gasification. It includes environmental effects, the different processes and techniques that are used, gas removal, rock fracturing, costs, and economics. (This updated bibliography contains 269 abstracts, 106 of which are new entries to the previous edition.)

  20. Underground coal gasification (citations from the NTIS Data Base). Report for 1979-Apr 80

    Energy Technology Data Exchange (ETDEWEB)

    Cavagnaro, D.M.

    1980-05-01

    The bibliography of Federally-sponsored research cites many aspects of in-situ gasification techniques, including rock fracturing, combustion, gas removal, economics, costs, and environmental factors. (This updated bibliography contains 93 abstracts, 53 of which are new entries to the previous edition.)

  1. Chemical analysis of steel (citations from the NTIS Data Base). Report for 1964-Apr 80

    Energy Technology Data Exchange (ETDEWEB)

    Cavagnaro, D.M.

    1980-05-01

    Information is cited on chemical analysis of boron, nitrogen, hydrogen, sulfur, silicon, carbon, oxygen, aluminum, rare earths, and other trace elements in steel. In addition, research on the determination of major elements, including iron, is covered. New techniques and refinement of older techniques, including x-ray fluorescence, spectroscopy, chromatography, activation analysis, and wet chemical methods are also included. (This updated bibliography contains 240 abstracts, 14 of which are new entries to the previous edition.)

  2. Minimizing infarct size. Annual scientific report, 1 Jul 1975--15 Apr 1976

    Energy Technology Data Exchange (ETDEWEB)

    Braunwald, E.

    1976-04-15

    Several goals were achieved during this period of 9 months, both in the experimental laboratory and in patients with acute myocardial infarction. (1) A study of the effects of aprotinin administration on myocardial ischemic injury, subsequent necrosis and collateral blood flow following acute coronary artery occlusion was carried out to completion. (2) A study of the effect of cobra venom factor on myocardial necrosis was completed and the factors responsible for its action were examined. (3) A comparison was made of the effects of nitroglycerin and nitroprusside on ischemic injury and regional myocardial blood flow in patients with acute myocardial infarction and in dogs with coronary occlusions. (4) A method of direct measurement of infarct size in the rat was developed. It consists of occlusion of the main left coronary artery and the histologic quantification of the infarct at 48 hours and 3 weeks later by serial histologic sections or alternatively by measuring total left ventricular myocardial creative phosphokinase activity. (5) New electrocardiographic methods have been developed in order to evaluate atraumatically the extent of myocardial infarction in patients. (6) Intravenous injection of (113)mIn-ENTMP and (99m)TcENTMP in dogs following coronary artery occlusion permitted a sequential double labeling of the damaged myocardium. (7) Since hyaluronidase is a very effective drug in reducing myocardial damage both in the experimental animal and in patients with acute myocardial infarction, a study was carried out to ascertain its effects on collateral flow.

  3. Sexual dysfunctions after prostate cancer radiation therapy; Dysfonctions sexuelles apres irradiation pour cancer de la prostate

    Energy Technology Data Exchange (ETDEWEB)

    Droupy, S. [Service d' urologie-andrologie, CHU Caremeau, 30 - Nimes (France)

    2010-10-15

    Sexual dysfunctions are a quality of life main concern following prostate cancer treatment. After both radiotherapy and brachytherapy, sexual function declines progressively, the onset of occurrence of erectile dysfunction being 12-18 months after both treatments. The pathophysiological pathways by which radiotherapy and brachytherapy cause erectile dysfunction are multi-factorial, as patient co-morbidities, arterial damage, exposure of neurovascular bundle to high levels of radiation, and radiation dose received by the corpora cavernosa at the crurae of the penis may be important in the aetiology of erectile dysfunction. Diagnosis and treatment of postradiation sexual dysfunctions must integrate pre-therapeutic evaluation and information to provide to the patient and his partner a multidisciplinary sexual medicine management. (authors)

  4. State of the Art Report for Development of Control Element Drive Mechanism of the APR+ Reactor

    International Nuclear Information System (INIS)

    Recently newly-developed nuclear reactors with increased safety and enhanced performance by developed countries in the nuclear area are competing in the global nuclear market. Several reactors, for example AP600 and AP1000 by Westinghouse Electric Co. in USA, EPR by Areva in Europe, APWR by Mitsubishi Heavy Industry in Japan in the pressurized power reactor, are competing to preoccupy the nuclear market during Nuclear Renaissance. Dedicated control element drive mechanism with enhanced performance and increased safety are developed for these new reactors. And load follow capability is required, and it is estimated that load follow requirement make design requirement of a control element drive mechanism harsh. It is necessary to review the current technical state of a control element drive mechanism. This work is aimed to review the design characteristics of a past and current control element drive mechanism for a nuclear reactor and to check the direction and goal of CEDM design development recently

  5. Optically pumped metal vapor lasers. Final technical report, 15 Apr 1978-15 Jul 1980

    International Nuclear Information System (INIS)

    The properties of optically-excited Hg/NH3 and Hg/ND3 mixtures have been studied as a function of mercury pressure in the range 1 to 40 torr. At low mercury pressures, less than or equal to 1 torr, the well-known uv emission band due to HgNH3* is dominant; this regime has been investigated extensively over the past ten years. However, at higher pressures the uv band disappears and is replaced by a strong green emission band, centered near 500 nm. From a detailed study of the spectral and temporal characteristics of the green band, it is concluded that it arises from the formation of the Hg2NH3* (or Hg2ND3*) excited molecular complex. The lifetime of this exciplex has been measured and is found to be 3.8 μsec (+- 25%). Because of interest in the system as a potential energy storage laser medium, optical transmission measurements have been carried out at selected wavelengths. Net absorption has been observed across the green band at high mercury density, as well as in the uv band in the low density regime

  6. Thyroid cancer following exposure to ionising radiation; Cancer de la thyroide apres exposition aux rayonnements ionisants

    Energy Technology Data Exchange (ETDEWEB)

    Schlumberger, M. [Institut de cancerologie Gustave-Roussy, 114, rue edouard-Vaillant, 94805 Villejuif cedex (France); Universite Paris Sud 11, 114, rue edouard-Vaillant, 94805 Villejuif cedex (France); Chevillard, S.; Ory, K. [Commissariat a l' energie atomique et aux energies alternatives, route du Panorama, 92265 Fontenay-aux-Roses cedex (France); Dupuy, C. [Institut de cancerologie Gustave-Roussy, 114, rue edouard-Vaillant, 94805 Villejuif cedex (France); Universite Paris Sud 11, 114, rue edouard-Vaillant, 94805 Villejuif cedex (France); UMR 8200 CNRS, 114, rue edouard-Vaillant, 94805 Villejuif cedex (France); Le Guen, B. [Division production nucleaire, direction production ingenierie, EDF, Tete-Pleyel, 1, place Pleyel, 93282 Saint-Denis cedex (France); De Vathaire, F. [Institut de cancerologie Gustave-Roussy, 114, rue edouard-Vaillant, 94805 Villejuif cedex (France); Universite Paris Sud 11, 114, rue edouard-Vaillant, 94805 Villejuif cedex (France); equipe d' epidemiologie des radiations, centre d' etudes en sante des populations, UMR 1018 Inserm, 114, rue edouard-Vaillant, 94805 Villejuif cedex (France)

    2011-08-15

    Exposure to ionising radiations during childhood increases the risk of thyroid cancer. Similar risk factors have been found after external radiation exposure or internal contamination with radioactive iodine isotopes. In case of contamination with radio-iodines, administration of potassium iodide can prevent thyroid irradiation. (authors)

  7. Salvage treatments for prostatic radiation failure; Traitements de rattrapage apres radiotherapie prostatique

    Energy Technology Data Exchange (ETDEWEB)

    Baumert, H. [Service d' urologie, groupe hospitalier Paris Saint-Joseph, 75 - Paris (France)

    2010-10-15

    Local recurrence after external radiotherapy or brachytherapy occurs in 30% of patients treated for prostate cancer. These recurrences can be localised to the prostate and controlled by salvage treatment. Salvage prostatectomy is the gold standard treatment, however, it is associated with a high morbidity rate. Minimally invasive treatments such as cryo-therapy and high intensity focused ultrasound (HIFU) can be proposed to treat local recurrences. Indications, complications and oncological results of these salvage treatments are discussed in this article. (author)

  8. Multiple assets position determination in a 3-dimensional environment using the APRS protocol

    OpenAIRE

    Foutzitzis, Evangelos K.

    2007-01-01

    Increased situational awareness in the battlefield is one of the main objectives in today?s operations and applies to all levels of commands. Several attempts have been made to use tracking devices for detecting and continuously updating the positional data of friendly assets on a map. Current applications like Falcon View fulfill their objective in presenting the location of targets of interest on a digital mapping environment. Falcon View is a geographic information system (GIS) used extens...

  9. Pas de roman avant le mariage, tous les romans après le mariage

    Directory of Open Access Journals (Sweden)

    Tone Smolej

    2002-11-01

    Full Text Available Dans cet article, l’auteur explore la bibliothèque imaginaire des personnages du cycle des Rougon-Macquart, d’Émile Zola. Il se penche plus particulièrement sur les livres lus par deux catégories de personnages : les révoltés à l’égard du système politique et les jeunes filles.

  10. Numerical analysis of APR1400 Steam Generator by CUPID/MARS heat structure coupling

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jae Ryong Lee; Lee, Seung Jun; Pakr, Ik Kyu; Yoon, Han Young [KAERI, Daejeon (Korea, Republic of); Cho, Hyoung Kyu [Seoul National University, Seoul (Korea, Republic of)

    2015-05-15

    To design and analyze steam generators, many computer codes have been developed and used around the world. In this study, the coupled CUPID and MARS code was used for the simulation of boiler side of the PWR steam generator. This paper presents the description of the coupling method, validation for porous media approach against the rod bundle experiment and the preliminary simulation results of PWR steam generator using the coupled code. In the present study, the multi-scale thermal-hydraulic analysis method using the coupled CUPID/MARS code was applied for the simulation of the steam generator. The primary side of the steam generator and other RCS was simulated by MARS and the secondary side was calculated by CUPID with porous media approach. For coupled simulation, the porous medium was applied in order to take into account the effect of the U-tube bundle and other supporting structure which play a role to be a flow resistance. More realistic physical model such as moisture separator slug behavior should be developed for the near future. The application of the coupled simulation should be extended to the accident scenario.

  11. IAEA Newsbriefs. V. 15, no. 2(87). Apr-May 2000

    International Nuclear Information System (INIS)

    This issue gives information about the following topics: meeting of states for review of global nuclear non-proliferation treaty, status of signatures of Additional Protocols for strengthened safeguards system as of April 2000, IAEA participation in projects on water resources in relation to the world water day 2000, IAEA's programmes and activities for technology transfer, IAEA international symposia and seminars, safety of radioactive waste management, joining international conventions in nuclear field by more states, status of nuclear power around the world as of April 2000, and other short information

  12. IAEA Newsbriefs. V. 13, no. 2(79). Apr-May 1998

    International Nuclear Information System (INIS)

    This issue gives brief information on the following topics: IAEA Board Meetings Set in May and June, Database of the IAEA's International Nuclear Information Systems (INIS) is being made available over the Internet free of charge, Senior Expert Group Starts Review of IAEA Programmes, IAEA Reports to Security Council on Nuclear Inspections in Iraq, Parties Consider Extending Fusion Research through the ITER Project, Status of Joint Safety and Nuclear Liability Conventions, Proposed Global Convention Against Nuclear Terrorism, Upcoming Symposia and Conferences, New IAEA Books, Nuclear Data File, and other short information

  13. Energy-conserving coating - pigment research. Final report, Sep 88-Apr 91

    Energy Technology Data Exchange (ETDEWEB)

    Novinson, T.

    1991-05-01

    This report documents research into novel experimental paints made from color-reversible pigments. These pigments are of two types: Photochromic and thermochromic. The first group changes color on exposure to light, and the second changes color when subjected to a change in temperature. If successfully incorporated into a coating and applied to walls and roofs, these pigments could reduce heating and cooling costs by presenting a more absorbent color in the winter and a more reflective color in the summer.

  14. L'économie publique locale quinze ans après : entre espace et territoire

    OpenAIRE

    Guy Gilbert; Alain Guengant

    2002-01-01

    The paper concentrates on the changes which would be necessary to introduce in a new edition of the textbook « Économie Publique Locale » authored by Pierre-Henry DERYCKE and Guy GILBERT and first published in 1988, in order to take into account the development of economic analysis and the evolution of the institutional and economic conditions since that time. Two perspectives are chosen ; the first one highlights the development of spatial economic theory, the second emphasizes an institutio...

  15. L'avortement en France, vingt ans après la loi

    OpenAIRE

    Fougeyrollas, Béatrice; Zaidman, Claude

    2009-01-01

    Béatrice Fougeyrollas, médecin généraliste qui travaille dans un centre d'IVG depuis plus de 10 ans, nous livre ses réflexions (propos recueillis par Claude Zaidman) Je suis médecin généraliste et je travaille dans un centre d'IVG depuis plus de 10 ans. Dans cette structure, nous pratiquons des interruptions de grossesse mais nous avons aussi une très grosse activité de consultations de contraception et de consultations gynécologiques courantes, c'est-à-dire que les femmes nous demandent de l...

  16. RRS James Cook Cruise 71, 29 Apr - 12 May 2012. Porcupine Abyssal Plain: sustained ocean observation

    OpenAIRE

    Lampitt, R.S.; et al.

    2013-01-01

    The objective of the PAP observatory is to provide high temporal resolution (hours) of an increasing number of variables which are relevant from the perspective of the biology, physics and chemistry of the upper water column, the midwater and the underlying seabed. These observations are made over a relatively small spatial scale (30km) in the open ocean over a very flat area of seabed at a depth of 4800m. The site has been under examination for over 20 years and during that time, substantial...

  17. State of the Art Report for Development of Control Element Drive Mechanism of the APR+ Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jae Seon; Choi, Suhn; Song, Chul Hwa

    2008-10-15

    Recently newly-developed nuclear reactors with increased safety and enhanced performance by developed countries in the nuclear area are competing in the global nuclear market. Several reactors, for example AP600 and AP1000 by Westinghouse Electric Co. in USA, EPR by Areva in Europe, APWR by Mitsubishi Heavy Industry in Japan in the pressurized power reactor, are competing to preoccupy the nuclear market during Nuclear Renaissance. Dedicated control element drive mechanism with enhanced performance and increased safety are developed for these new reactors. And load follow capability is required, and it is estimated that load follow requirement make design requirement of a control element drive mechanism harsh. It is necessary to review the current technical state of a control element drive mechanism. This work is aimed to review the design characteristics of a past and current control element drive mechanism for a nuclear reactor and to check the direction and goal of CEDM design development recently.

  18. Musique et conflits armés après 1945

    OpenAIRE

    Anagnostou, Panagiota; Buch, Esteban; Castanet, Pierre Albert; Cusick, Suzanne G.; Fryberger, Annelies; Gómez Gálvez, Mauricio; Grant, Morag Josephine; Gribenski, Fanny; Hallam, Huw; Jardin, Étienne; Mayaud, Isabelle; Nuxoll, Cornelia; Pédelaborde, Cindy; Ramaut-Chevassus, Béatrice; Rogers, Jillian

    2014-01-01

    Dans son ouvrage De la guerre, paru pour la première fois en 1832, Carl von Clausewitz affirme que la guerre se situe à l’intérieur des rapports politiques : elle serait un véritable « instrument politique, une continuation des rapports politiques, la réalisation des rapports politiques par d’autres moyens ». Ainsi, l’un des apports les plus importants de la pensée de Clausewitz à la compréhension de la guerre, résultant de ce postulat, serait que celle-ci ne constitue pas la rupture d’un pro...

  19. Optical pattern recognition III; Proceedings of the Meeting, Orlando, FL, Apr. 21, 22, 1992

    Science.gov (United States)

    Casasent, David P. (Editor); Chao, Tien-Hsin (Editor)

    1992-01-01

    Consideration is given to transitioning of optical processing into systems (TOPS), optical correlator hardware, phase-only optical correlation filters, optical distortion-invariant correlation filters, and optical neural networks. Particular attention is given to a test target for optical correlators, a TOPS electronic warfare channelizer program, a portable video-rate optical correlator, a joint transform correlator employing electron trapping materials, a novelty filtered optical correlator using a photorefractive crystal, a comparison of correlation performance of smart ternary phase-amplitude filters with gray-scale and binary input scenes, real-time distortion-tolerant composite filters for automatic target identification, landscaping the correlation surface, fast designing of a circular harmonic filter using simulated annealing, feature-based correlation filters for distortion invariance, automatic target recognition using a feature-based optical neural network, and a holographic inner-product processor for pattern recognition.

  20. Autour d'un petit livre. Alfred Loisy cent ans après

    OpenAIRE

    Losito, Giacomo

    2010-01-01

    Ce volume recueille les actes d'un colloque dont il faut savoir gré à Emile Goichot, Claude Langlois et François Laplanche de l'avoir organisé en mettant à contribution les meilleurs spécialistes allemands, suisses et italiens de la crise moderniste, à côté des historiens français de longue date (Pierre Colin, Bernard Montagnes et le doyen des études de Modernistica, Emile Poulat), des spécialistes des sciences religieuses de l'École Pratique des Hautes Études, des théologiens du Centre Sèvre...

  1. Numerical analysis of APR1400 Steam Generator by CUPID/MARS heat structure coupling

    International Nuclear Information System (INIS)

    To design and analyze steam generators, many computer codes have been developed and used around the world. In this study, the coupled CUPID and MARS code was used for the simulation of boiler side of the PWR steam generator. This paper presents the description of the coupling method, validation for porous media approach against the rod bundle experiment and the preliminary simulation results of PWR steam generator using the coupled code. In the present study, the multi-scale thermal-hydraulic analysis method using the coupled CUPID/MARS code was applied for the simulation of the steam generator. The primary side of the steam generator and other RCS was simulated by MARS and the secondary side was calculated by CUPID with porous media approach. For coupled simulation, the porous medium was applied in order to take into account the effect of the U-tube bundle and other supporting structure which play a role to be a flow resistance. More realistic physical model such as moisture separator slug behavior should be developed for the near future. The application of the coupled simulation should be extended to the accident scenario

  2. Long Lake Nat'l. Wildlife Narrative-Jan.-Feb.-Mar.-Apr. 1944

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Long Lake NWR outlines Refuge accomplishments from January through April of 1944. The report begins by summarizing the weather conditions...

  3. An IntervIew wIth Maria DiCenzo, London AprIl 2011

    OpenAIRE

    Skoog, Kristin

    2011-01-01

    Dr Maria DiCenzo is Associate Professor of English and Film Studies at Wilfrid Laurier University (Canada).1 Her research focuses on feminist media history, particularly late nineteenth- and early twentieth-century women’s print media and social movements, as well as twentieth-century British political theatre. DiCenzo has published widely on the late Victorian and Edwardian feminist periodical press, and she has also provided thoughtful and provocative commentary on the development of femini...

  4. The nuclear risk: Chernobylsk eight years after. Le risque nucleaire: Tchernobyl huit ans apres

    Energy Technology Data Exchange (ETDEWEB)

    Giraud, R.

    1994-01-01

    When Chernobylsk-4 reactor explodes in april 1986, more than 1.8*10[sup +18] becquerels were disseminated around. Effects on human populations show that thyroid cancers, leukemias, stress effects (increase of drugs and alcohol consumption, psychosomatic troubles...) strongly growth, and that low radiation doses carry a deregulation of lipids metabolism. A new sarcophagus must be built. Treatment of radioactive wastes (350.000 m[sup 3]) was done in urgency and must be done now or put in the new sarcophagus. And there are in the ex-USSR 15 high risks reactors. (A.B.). 5 refs., 9 photos.

  5. People and things. CERN Courier, Apr 1991, v. 31(3)

    International Nuclear Information System (INIS)

    The article reports on achievements of various people, staff changes and position opportunities within the CERN organization and contains news updates on upcoming or past events: ; In 1992 the XVth International Conference on High Energy Accelerators will be held from 20-24 July at the Congress Centrum, Hamburg, Germany. ; The 100 or so places for the CERN Accelerator School's 'Radiofrequency Engineering for Particle Accelerators' course in Oxford from 3-10 April were sold out well in advance. ; A Symposium on Quantum Physics, in memory of John Stewart Bell who died on 1 October 1990 will be held at CERN on 2-3 May

  6. Quelques aspects des paysages ruraux kosovars d'après guerre

    OpenAIRE

    Barthes, Angela

    2005-01-01

    Les campagnes kosovares sont radicalement transformées depuis la perte du statut de région autonome (1989) et la survenue des conflits. Aujourd'hui, les coopératives agricoles et les industries agro-alimentaires d'état ont cessé de fonctionner. Aujourd'hui, les friches dominent, malgré la reprise micro-économique de structures d'exploitations familiales. En conséquence de la présence de multiples constructions anarchiques inachevées, le paysage ressemble à un vaste chantier désorganisé parsem...

  7. La signifiance du rêve cent ans après

    OpenAIRE

    Rey-Flaud, Henri

    2011-01-01

    Partant d’une note rajoutée à la Traumdeutung en 1925, selon laquelle le rêve ne se réduit ni à son contenu manifeste, ni à son contenu latent, mais consiste dans le travail qu’il produit, l’auteur entreprend d’établir que le rêve est l’espace élu où s’énonce la vérité pure du désir (Begierde) derrière le voile des souhaits énoncés (Wünsche). Ce principe oblige à distinguer les signifiants fondamentaux du sujet (les « lettres »), proximes du cœur ombilical du rêve, et les représentations de c...

  8. Simulation of Transient Scenarios for Passive Auxiliary Feedwater System in APR+

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Byounguhn; Kim, Seok; Park, Yusun; Kang, Kyungho [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-05-15

    In this study, postulated transient scenarios occurring in the PAFS were simulated to evaluate the operational performance of system and investigate the thermal hydraulic phenomena of the two-phase natural convection flow. The transient tests simulated in this study are PAFS start-up actuation test (SU) and non-condensable gas effect test (NC). In this study, postulated transient cenarios occurring in the PAFS were simulated to evaluate the performance of the condensation heat transfer and investigate the thermal hydraulic phenomena of the two-phase natural convection flow. Start-up actuation test simulated the initial transient when the PAFS actuation signal was generated and the natural convection flow was initiated in the loop, and any significant two-phase flow instability was not observed in the test. The purpose of the non-condensable gas effect test is to study the characteristics of the condensation heat transfer in the heat exchanger when the nitrogen gas was injected. The test results proved that the existence of the non-condensable gas up did not produce a meaningful decrease of the cooling capability in the PAFS. From the experimental results described above, the cooling and operating performance of the PAFS was validated with respect to occurrence of the various transient scenarios and it was proved that the function of the PAFS can be effectively performed during the transient situation. The result will be also utilized in validation of the thermal hydraulic system code in the future.

  9. Simulation of Transient Scenarios for Passive Auxiliary Feedwater System in APR+

    International Nuclear Information System (INIS)

    In this study, postulated transient scenarios occurring in the PAFS were simulated to evaluate the operational performance of system and investigate the thermal hydraulic phenomena of the two-phase natural convection flow. The transient tests simulated in this study are PAFS start-up actuation test (SU) and non-condensable gas effect test (NC). In this study, postulated transient cenarios occurring in the PAFS were simulated to evaluate the performance of the condensation heat transfer and investigate the thermal hydraulic phenomena of the two-phase natural convection flow. Start-up actuation test simulated the initial transient when the PAFS actuation signal was generated and the natural convection flow was initiated in the loop, and any significant two-phase flow instability was not observed in the test. The purpose of the non-condensable gas effect test is to study the characteristics of the condensation heat transfer in the heat exchanger when the nitrogen gas was injected. The test results proved that the existence of the non-condensable gas up did not produce a meaningful decrease of the cooling capability in the PAFS. From the experimental results described above, the cooling and operating performance of the PAFS was validated with respect to occurrence of the various transient scenarios and it was proved that the function of the PAFS can be effectively performed during the transient situation. The result will be also utilized in validation of the thermal hydraulic system code in the future

  10. La formule des traces tordue d'apr\\`es le Friday Morning Seminar

    CERN Document Server

    Labesse, Jean-Pierre

    2012-01-01

    Based on the notes of the Friday Morning Seminar held in the IAS in 1983-1984 (often quoted as Morning Seminar on the Trace Formula), we give a complete and detailed proof of the Twisted Trace Formula in its primitive form i.e. its noninvariant form. ----- Notre ambition est de donner, en nous basant pour l'essentiel sur les notes du Friday Morning Seminar de l'IAS en 1983-1984 (souvent cit\\'e sous le nom de Morning Seminar on the Trace Formula), une version compl\\`ete de la preuve de la formule des traces dans le cas tordu dans sa version primitive c'est-\\`a-dire non invariante.

  11. Acute exercise does not induce an acute phase response (APR) in Standardbred trotters

    DEFF Research Database (Denmark)

    Kristensen, Lena; Buhl, Rikke; Nostell, Katarina; Bak, Lars; Petersen, Ellen; Lindholm, Maria; Jacobsen, Stine

    2014-01-01

    have been caused by exercise-induced hemolysis, which indicates that horses might experience a condition similar to athlete’s anemia in humans. The pathogenesis and clinical implications of the hematological and blood-biochemical changes elicited by acute exercise in Standardbred trotters in the...

  12. Retour à Adam Smith (1723-1790) après deux siècles?

    OpenAIRE

    Pelletier, Gérard-R.

    1990-01-01

    After a review of current assessments of Smithian economics, the author stresses the interest of the entire system at historical, sociological and ethical levels. The renewed interest in Smith comes from his ethical positions rather than from his skills as an economic analyst. The solution to the vexing problem of ever finding an acceptable ethics in distribution theory seems to be found somewhere between utilitarian and deontological theories. But neither of these two theories alone succeeds...

  13. IAEA Newsbriefs. V. 14, no. 2(83). Apr-May 1999

    International Nuclear Information System (INIS)

    This issue gives brief information on the following topics: Nuclear Safety: States Taking 'Steps in Right Direction', Contracting Parties to Convention on Nuclear Safety, Nuclear Power Worldwide, Nuclear's Future: Director General Address in Japan, Year 2000 Programme and Budget Goes Before IAEA Board, The IAEA and Y2K Issues: Reports, Workshops, Internet Links, Strengthened Safeguards System: Status of Additional Protocols, States Join International Conventions in Nuclear Fields, IAEA International Scientific Symposia and Seminars in 1999, In Memoriam: Munir Ahmad Khan, and other short information

  14. Radioactivity survey of total diet for Saitama residents. Apr. 2011 - Mar. 2013

    International Nuclear Information System (INIS)

    In order to estimate the human intake and the committed effective dose of several radioactive materials, the duplicate diet samples sampled from Saitama residents were analyzed. The average daily intakes of 134Cs and 137Cs in 2011 were 0.43 and 0.48 Bq/person·day, and those in 2012 were 0.065 and 0.15 Bq/person·day. The committed effective doses in 2011 and 2012 are estimated to be 5.5 and 1.1 μSv, respectively. The estimated dose in 2011 is almost 80 times higher than that before the occurrence of Fukushima Daiichi Nuclear Power Plant accident. However, it is found that this dose is less than 1% of the annual effective dose limit for members of the public (1 mSv/year). (author)

  15. Long Lake National Wildlife Refuge: Narrative report: Jan.-Apr., 1947

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Long Lake NWR outlines Refuge accomplishments from January through April of 1947. The report begins by summarizing the weather conditions...

  16. Green fuels, growth engines after petroleum; Les carburants verts, moteurs de la croissance apres le petrole

    Energy Technology Data Exchange (ETDEWEB)

    Mili, Dino

    2010-09-15

    The contribution of the new fuels to a greener environment is important and immediate. Thanks to clean novel technologies and to commercial plant projects in development, companies like Enerkem contribute to satisfy increasing global demand for clean energy. They stimulate local economies by creating jobs in an industry that offers real growth potential. Green fuels will gradually allow us to let go of non sustainable energy sources like oil to adopt a way of life based on sustainable development. They will also allow a shift towards a green economy. [French] La contribution des nouveaux carburants a un environnement plus vert est importante et immediate. Grace a des technologies propres novatrices et a des projets d'sines commerciales en developpement, des entreprises comme Enerkem contribuent a satisfaire a la demande mondiale croissante en energie propre. Elles stimulent les economies locales par la creation d'emplois dans une industrie qui offre un veritable potentiel de croissance. Les carburants verts permettront graduellement de nous affranchir des sources d'energie non renouvelables comme le petrole pour adopter un mode de vie base sur le developpement durable. Ils permettront aussi un virage vers une economie verte.

  17. IAEA Newsbriefs. V. 11, no. 2(71). Apr-May 1996

    International Nuclear Information System (INIS)

    This issue gives brief information on the following topics: Chernobyl Conference sums up Scientific Understanding, International Forum on the Safety of RBMK Reactors, IAEA Board of Governors, Radiological Study of the Mururoa and Fangataufa Atolls, Safeguards Support, Workshop on Modelling Methods for Water Systems, Uranium Market Trends, Security Council Resolution on Iraq, South East Asian NWFZ, Radioactive Waste Management, Nuclear Seminar in Poland, and other short information

  18. Space Congress, 29th, Cocoa Beach, FL, Apr. 21-24, 1992, Proceedings

    Science.gov (United States)

    The present volume on the quest for new frontiers in space discusses weather impacts on space operations, planning for the performance of future space bases, a new guidance and control unit for the Titan IV vehicle, and nondestructive evaluation of Shuttle Columbia tiles. Attention is given to Space Shuttle payload accommodations and trends in customer demands, a generic propellants transfer unit, making space part of general education, space station on-orbit solar array loads during assembly, and dimensional stability of the attitude reference assembly on SSF. Topics addressed include National Launch System payload accommodations and launch operations, the integrated factory/launch site processing concept, Pioneer 10 interstellar studies, and the role of advanced nuclear propulsion systems in precursor interstellar missions. Also discussed are legal challenges in realizing interstellar initiatives, Mars transportation system synthesis, and NASA's commercial space program. (For individual items see A93-25277 to A93-25313)

  19. Thermionics. A bibliography with abstracts. Search period covered: 1970--Apr 1975. [190 references

    Energy Technology Data Exchange (ETDEWEB)

    Grooms, D.W.

    1975-04-01

    Research on thermionic power generation, power plant design, converter design, and basic research on thermionic materials are cited in the bibliography. Spacecraft applications are included. (Contains 190 abstracts).

  20. Study on the VFD (Variable Frequency Drive) for RCP (Reactor Coolant Pump) Motors of APR1400

    International Nuclear Information System (INIS)

    Most industrial facilities are continually searching for ways to reduce energy costs while increasing or maintaining current production. In terms of electric motors, Variable Frequency Drive (VFD) units represent a critical opportunity for energy savings. Currently, VFDs are used on about ten (10) percent of industrial process motors, and this percentage is increasing every year. Properly applied VFDs have been documented to save as much as fifty percent of the energy consumed by certain industrial processes. Nuclear Power - Power plants in general and Nuclear Power Plants (NPPs) in particular are slow to adopt new technology. The nuclear power industry requires a nearly absolute demonstration through operating experience in other industries in which the new approach will result in a net improvement in plant reliability without any surprises. Only recently has the nuclear industry begun to adapt VFD units for large motors. Specifically, there are several examples in the Boiling Water Reactor (BWR) fleet of replacing Motor-Generator (M-G) sets with VFD units for Reactor Recirculation (RR) pump motor service. At one station, VFD units were introduced upstream of the Circulating Water (CWP) pump motors to address environmental issues. They units are taking advantage of VFD technology whose benefits include increased reliability, reduction in electrical house load, improved flow control, and reduced maintenance. RCP Application - In the case of new generation, it has been reported that the Westinghouse AP1000 will make use of VFD units for the Reactor Coolant Pump (RCP) motors

  1. La bourse, un contenant qui court après son contenu*

    OpenAIRE

    Tournier, Maurice

    2014-01-01

    Où les grippe-sous d’autrefois serraient-ils leur "monnaie courante" ? Dans une bourse, un boursicaud, une boursette, voire une bougette, une aumônière, un escars, voire une escarcelle. Pour les plus riches, l’or s’est mis à dormir en tas, laissant le "cours" aux billets puis aux chèques ; les mots de la petite thésaurisation ont alors disparu. Seule est restée la Bourse, drainant vers elle les économies des autres. L’art de tirer l’argent des poches. Des poches grèques, par exemple. C’est la...

  2. Aspekty managementu hudebního festivalu Apríles

    OpenAIRE

    Wildová, Veronika

    2012-01-01

    The work deals with the management of cultural events in the open air, and focuses on music festivals. It examines the development of the concept of popular music festivals since their beginning and maps festivals in the Czech Republic. It is based on the personal experience of the author with the organization of the festival, and describes various aspects of event management from concept to its realization. Points out the difficulties that occur in the organization, and proposes a solution o...

  3. 15 CFR 781.2 - Purposes of the Additional Protocol and APR.

    Science.gov (United States)

    2010-01-01

    ... Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL.../Infcircs/index.html), except that it excludes IAEA access to activities with direct national security... about aspects of the U.S. civil nuclear fuel cycle, including: Mining and concentration of nuclear...

  4. Infrared optical materials VI; Proceedings of the Meeting, Orlando, FL, Apr. 4, 5, 1988

    Science.gov (United States)

    Musikant, Solomon

    1988-01-01

    Recent advances in IR optics are discussed in reviews and reports. Topics addressed include IR sensors and mirrors, IR-transmitting ceramics, IR waveguides, and IR glasses. Consideration is given to in situ visualization of the solid-liquid interface during crystal growth, (HgZn)Te IR photovoltaic detectors, lanthana-strengthened yttria IR-transmitting materials, high-temperature transmission measurements of IR window materials, fabrication of heavy-metal-fluoride glass fibers containing ultralow amounts of oxygen and water, and the material properties required for hollow fibers transmitting high-power IR radiation.

  5. Fibre optics '90; Proceedings of the Meeting, London, England, Apr. 24-26, 1990

    International Nuclear Information System (INIS)

    The present conference on fiber optics emphasizes the use of components, devices, and materials for hostile environments, and also encompasses applications of optoelectronics in sensors, communications, 'white light' interferometry, the properties of monomode optical fibers, and coherent optical systems. Specific issues addressed include erbium-doped fiber amplifiers in communications, the use of optical amplification in communication, optical fibers in the adverse space environment, the effects of temperature variations on loose-tube and tight-buffered optical fiber cables, and radiation effects in polarization-maintaining fibers. Also addressed are methods to test the effects of high-ionizing-radiation dose rates on optical fiber data links, sensors for meteorological data acquisition, sensor technology for smart structure development, radiative ignition by loose agglomerates of fine fibers, and a multipurpose evanescent mode-coupling-based device

  6. APR-5000-XLS阵列封装返工系统

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    APR—5000-XLS阵列封装返工系统可处理BGA,CSP,LGA,Micro SMD,MLF(Micro—Lead Frame),BCC(Bumped Chip Copponent)多种封装。其可处理的板尺寸达610cm-610cm,厚度达6.35mm。双程、全空气底部预热,能处理大小不同规格的PCB板。采用5个热电偶输入和闭环RTD温度控制,可分析多点温度,精细控制返工区的温度。计算机监控时间、温度、加热气流量,保证进程控制和高重复性。

  7. High energy gain, high quality laser particle accelerator development at JAERI-APR

    International Nuclear Information System (INIS)

    Recent activities related to laser-plasma acceleration at Advanced Photon Research Center, Japan Atomic Energy Research Institute are presented. Gas density measurements of a pulsed gas valve and wakefield measurements have been performed with two types of interferometers. A wakefield of 20 GV/m excited in the gas-jet plasma has been obtained at a plasma density of 7x1017 cm-3. We have shown by 1D-3V particle-in-cell simulation that a high quality electron beam with a transverse emittance of 0.3 π mm-mrad and with an energy of 7.0±0.5 MeV can be produced using a colliding optical injection. Our proposed experiments using a 100 TW laser beam and a 150 MeV electron beam are also presented

  8. Monthly results of measurements. Apr 1999; Tableaux mensuels des mesures. Avril 1999

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    This report of the O.P.R.I. (Office of Protection against Ionizing Radiations) exposes the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, fishes), sea water around nuclear sites and other sites. The activities of various radioisotopes are presented in tables. (N.C.)

  9. Monthly results of measurements: Apr 1997; Tableaux mensuels des mesures. Avril 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    This report of the OPRI (Office of Protection against Ionizing Radiations) exposes the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, fishes), sea water around nuclear sites and other sites. The activities of various radioisotopes are presented in tables.

  10. Monthly results of measurements: Apr 2001; Tableaux mensuels des mesures. Avril 2001

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    This report of the OPRI (Office of Protection against Ionizing Radiations) exposes the principal results concerning the routine monitoring of environmental radioactivity in France: atmospheric dusts, rainwater, surface water, underground water, sewage water, drinking water, food chain (milk, vegetables, fishes), sea water around nuclear sites and other sites. The activities of various radioisotopes are presented in tables.

  11. Securite nutritionnelle a Haiti : situation avant et apres le seisme et recommandations pour l'avenir

    OpenAIRE

    Bassett, Lucy

    2010-01-01

    Children in Haiti are born into some of the harshest conditions on the planet, and are left at a disadvantage in terms of growth, development, and potential to thrive. Malnutrition rates in Haiti are among the worst in the Latin America and Caribbean Region. Nearly one-third of all children under-five suffer from stunted growth and three quarters of children 6-24 months are anemic. Malnutr...

  12. Intracellular proteinases Apr1p and CPz1p from Candida albicans

    Czech Academy of Sciences Publication Activity Database

    Bauerová, Václava; Dolejší, Elena; Hrušková-Heidingsfeldová, Olga; Pichová, Iva

    France : -, 2009. s. 96-96. [FEBS Advanced Lecture Course Human Fungal Pathogens Molecular Mechanism of Host-Pathogen /3./. 02.05.2009-08.05.2009, La Colle sur Loup] R&D Projects: GA ČR(CZ) GA310/09/1945; GA MŠk(CZ) LC531 Institutional research plan: CEZ:AV0Z40550506 Keywords : aspartic protease * Candida parapsilosis * carboxypeptidase Subject RIV: CE - Biochemistry

  13. Proliferation after the Iraq war; La proliferation apres la guerre d'Irak

    Energy Technology Data Exchange (ETDEWEB)

    Daguzan, J.F

    2004-09-15

    This article uses the Iraq war major event to analyze the approach used by the US to fight against proliferation. It questions the decision and analysis process which has led to the US-British intervention and analyzes the consequences of the war on the proliferation of other countries and on the expected perspectives. Finally, the future of proliferation itself is questioned: do we have to fear more threat or is the virtuous circle of non-proliferation well started? (J.S.)

  14. Study on thermal-hydraulic phenomena in porous media. Semiannual report Apr. 1998 to Mar. 1999

    International Nuclear Information System (INIS)

    This study deals with thermal-hydraulic phenomena in a porous media. When the foreign substances flow into the fuel subassembly with wire spacer, they would choke up the subchannel and form a porous blockage. The objective of this study is to clarify the thermalhydraulic phenomena in porous media and to develop the analytical method to predict the thermal-hydraulic field, deciding the maximum temperature on the fuel pin surface. This study is performed in cooperation with University of Tsukuba and Japan Nuclear Cycle Development Institute (JNC) from November 1997 to March 2000. This report describes the results for the second period from April 1998 to March 1999. In the last year, we confirmed that the visualization method used NaI solution as working fluid was applicable to flow visualization in the porous media. In this year period, we conducted the experiment to measure the velocity field inside and outside the blockage used Particle Image Velocimetry (PIV) analysis and Laser Doppler Velocimetry (LDV). The test section was simplified and 20 times enlarged the two subchannel of the fuel subassembly in the reactor, included the porous blockage consisted of the Pyrex grass spheres. NaI solution was used as the working fluid. When the concentration of NaI is 56.9wt% in the solution, the refraction-rate is correspond to that of the Pyrex grass. Before the experiment, we measured the density, viscosity, and thermal conductivity of 56.9wt% NaI solution. The velocity profile inside and outside the blockage was measured in detail. The knowledge was acquired of the relation of the flow in between the blockage and the unplugged channel. Moreover, we tried to measure the fluid temperature inside the blockage in the NaI solution, used Laser Induced Fluorescence (LIF) method. At the fist, we checked the relation between the brightness of the fluorescence and solution temperature. And then, we revealed that the LIF method could be used even in the NaI solution. (author)

  15. People and things. CERN Courier, Apr 1985, v.25(3)

    International Nuclear Information System (INIS)

    The article reports on achievements of various people, staff changes and position opportunities within the CERN organization and contains news updates on upcoming or past events. To commemorate the 25th anniversary of Austria's joining CERN and the forming of the first high energy physics group in the country, a celebration took place last November in the Auditorium of the old University of Vienna. From 25-28 February next year, another (the fourth) Vienna Wire Chamber Conference will take place. The fifth US Summer School on High Energy Particle Accelerators is to be held at the Stanford Linear Accelerator Center from 15-26 July

  16. LHC Beam Splash seen by the ATLAS detector - 5 Apr 2015 - run 260272 - event 6539

    CERN Multimedia

    ATLAS Collaboration

    2015-01-01

    Event display of one of the collimator "splash" events seen by the ATLAS experiment in LHC Run-2, on Tuesday April the 5th : run 260272, event 6539 . The collimator position is 140m in front of the ATLAS interaction point.

  17. Rice Lake Migratory Waterfowl Refuge: Quarterly narrative report for period ending Apr. 30, 1940

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This narrative report for Rice Lake NWR outlines Refuge accomplishments from February through April of 1940. The report begins by summarizing the weather conditions...

  18. The Erika tanker shipwreck, one year later. synthesis; Naufrage du petrolier Erika, un an apres. synthese

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-12-01

    In december 1999 the Erika tanker shipwreck broke along the Brittany coast leading to the most important sea pollution by hydrocarbons, since the Amoco-Cadiz. One year after this accident the Ministry of the territory management and of the environment takes stock on the actions carried on after the shipwreck: the management of the POLMAR fund, the shoreline cleaning, the land and water ecosystems restoration, the wastes storage and processing, the ecological consequences. A special part is devoted to the maritime transport regulations and safety and to the victims compensation. (A.L.B.)

  19. Breast cancers and leukaemias after irradiation. Cancers du sein et leucemies apres irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Vathaire, F. de (Centre de Lutte Contre le Cancer Gustave-Roussy, 94 - Villejuif (France))

    1994-01-01

    The influence of new data or recent re-analysis concerning the risks of breast cancer and leukaemia after irradiation is summarized in this article. The risk of breast cancer, particularly after irradiation during childhood, seems to be more important than estimated previously. Because the pattern of risk after irradiation seems to be multiplicative and since breast cancer is very frequent among western populations, these new findings may have important consequences in public health. Despite leukaemias have been known for a long time to be a radioinduced tumour, very little information is available about the effects of age at irradiation and dose rate. (author). 9 refs., 2 tabs.

  20. Construction of APR1000 nuclear power information management system based on international standards

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Seung Hwan [Korea Electric Power Research Institute, Daejeon (Korea, Republic of); Song, Deok Yong; Han, Byung Sub [Enesys Co., Daejeon (Korea, Republic of); An, Kyung Ik; Hwang, Jin Sang [PartDB Co., Daejeon (Korea, Republic of)

    2010-10-15

    In recent years, due to speedy rise of international oil prices, orders of nuclear power plant construction have been in progress by many countries to solve the stable supply of power. Our country has continued to perform nuclear power construction. As only a few developed countries like Japan and European countries have its own nuclear power construction technology, competition among them is keen. Our country has awarded the contract of UAE nuclear power plants based on the accumulated nuclear power plant construction technologies so far. In this regard, KEPCO has recognized the needs of information management system to manage nuclear power information and proceeded the implementation of nuclear power information management system for export-model

  1. People and things. CERN Courier, Apr 1990, v. 30(3)

    International Nuclear Information System (INIS)

    The article reports on achievements of various people, staff changes and position opportunities within the CERN organization and contains news updates on upcoming or past events: ; In a January 31 test at the Continuous Electron Beam Accelerator Facility (CEBAF) under construction at Newport News, Virginia, a beam from the injector's 500 keV room temperature section was accelerated to 2.5 MeV in one cavity of the quarter-cryomodule containing the injector's initial superconducting accelerating cavity pair. ; To explore in detail and update the physics possibilities for the Large Hadron Collider (LHC) project at CERN, the European Committee for Future Accelerators (ECFA) is now preparing for an LHC Workshop to be held in Aachen from 5-10 October. ; The 1990 CERN School of Computing, organized in collaboration with the Inter-University Institute for High Energies, VUB-ULB, Brussels, will take place from 2-15 September at Nieuwpoort, Belgium. ; To reinforce the increased spirit of cooperation resulting from CERN's growing attraction for scientists from all over Europe and from further afield, the Laboratory embarked last year on a programme of drawing up bilateral agreements to put ongoing collaboration on a firmer footing

  2. Apres le Deluge at State U: A Comprehensive Public University Responds to the Great Recession

    Science.gov (United States)

    Skinner, Richard A.; Miller, Emily R.

    2013-01-01

    In this article, the authors describe one institution--East Carolina University--that they think is representative of an important type and a large proportion of American universities, the comprehensive public university, and its responses to the lingering Great Recession. As a group, comprehensives handle almost 40 per cent of the total student…

  3. The Development of CPSES Plug-in(CPMP) for APR1400 Computerized Procedure Effective Maintenance

    International Nuclear Information System (INIS)

    The Computerized Procedure System (CPS) is one of the Man Machine Interface (MMI) resources of the Shin-Kori 3 and 4 nuclear power plants. The CPS is a computerized operator support system that enables operating crew to execute procedures in an accurate and fast manner. The Computerized Procedure (CP) is the XML data file in executable format that can be installed in the Procedure eXecution System (PXS) for execution. The CP contains specific information related to a particular procedure (i.e. LOCA). These computerized procedures such as Alarm Response Procedures (ARP) are separated into individual alarm procedure to maximize function interface between CPS and DCS. E.g. 'Procedure open by alarm list'. The procedure writer's burden to manage many procedures has been increased because of separated procedures. This paper introduces Computerized Procedure System Engineering System (CPSES) plug-in that is computerized procedure management program (CPMP) to reduce procedure writer's burden. This paper introduces the main features of CPMP. CPMP reduces procedure writer's or CPX maintainer's burden. This program is implemented and tested by program design requirement

  4. Beyrouth après la guerre : une géographie urbaine

    OpenAIRE

    Michael F. Davie

    1993-01-01

    Cette contribution vise à présenter les changements importants, induits par la guerre, qui ont affecté la ville de Beyrouth et ses banlieues depuis 1975. Elle se veut aussi un panorama de la recherche actuelle sur cette ville effectuée par des géographes, urbanistes et sociologues urbains tant en France qu'au Liban.

  5. RV Knorr Cruise KN200-4, 13 Apr-03 May 2011. RAPID Mooring Cruise

    OpenAIRE

    Johns, W.; Frajka-Williams, E.; et al, .

    2011-01-01

    This report describes the mooring operations conducted during RV Knorr cruise KN200-4 between 13 April and 3 May 2011. These mooring operations were completed as part of the United Kingdom Natural Environment Research Council (NERC) funded RAPID-WATCH Programme to monitor the Atlantic Meridional Overturning Circulation (MOC) at 26.5°N. The primary purpose on this cruise for the UK team was to service the RAPID Western Boundary moorings while the US teams worked on the Western Boundary Tim...

  6. La déstalinisation en Tchécoslovaquie après 1956

    Czech Academy of Sciences Publication Activity Database

    Pernes, Jiří

    Prague: Institut d'Histoire contemporaine de l'Academie des Science de la République tchéque, 2008 - (Flock, S.; Kocian, J.), s. 106-116 ISBN 978-80-7285-092-1 Institutional research plan: CEZ:AV0Z80630520 Keywords : communist regime * destalinisation * Czechoslovakia Subject RIV: AB - History

  7. Development of a Hi per PWR Fuel assembly for OPR1000 and APR1400

    International Nuclear Information System (INIS)

    KEPCO Nuclear Fuel Co., Ltd. (KNF) launched a new advanced high performance fuel development project in September of 2005, and the HIPER (High Performance with Efficiency and Reliability) fuel was successfully developed in 2010, accomplishing a series of out-of-pile tests. The HIPER Lead Test Assemblies (LTAs) were fabricated in early 2011, and LTA in-reactor verification testing was started in the mid of 2011. The LTAs are scheduled to undergo in-reactor verification testing over four years approximately, and then HIPER fuel will be supplied commercially after obtaining the commercial supply license. In this paper, the development objectives, main design features, including PWR fuel technology development strategy in Korea, out-of-pile test outlines and in-pile test plan for HIPER fuel are described

  8. IAEA Newsbriefs. V. 10, no. 1(67). Mar-Apr 1995

    International Nuclear Information System (INIS)

    This issue gives brief information on the following topics: IAEA Board to Consider Proposal on Safeguards, IAEA Director General to Address NPT Conference in mid-April, IAEA Hosts UN System-Wide Meeting, Joint IAEA/EC/WHO Conference on Chernobyl Announced, IAEA Concludes Post-Chernobyl Research Project, Uranium Data in Environmental Monitoring, Director General Address in Chile, South Africa, the Philippines Host Nuclear Information Seminars, Upcoming IAEA Conferences, Symposia and Seminars, Isotopes in Water Resources Management, Environmental Impacts of Radioactive Releases, Joint FAO/IAEA Symposium on Crop Improvement, Other Conferences, Symposia and Seminars in 1995, Safeguards and Non-Proliferation Developments (IAEA Safeguards Agreements, New NPT Members), Handbook on Nuclear Communications, SIT Campaign in Zanzibar, and other short information

  9. LHC Beam Splash seen by the ATLAS detector, 7 Apr 2015 - Run 260466 - event 22425

    CERN Multimedia

    Adam Bourdarios, Claire

    2015-01-01

    Event display of one of the collimator "splash" event seen by the ATLAS experiment in LHC Run-2 , on Tuesday April the 7th : event 22425, run 260466. The collimator position is 140m in front of the ATLAS interaction point. The spray of particles enters ATLAS from the left hand side of the picture. The length of the yellow bars indicates the energy deposited in the ATLAS calorimeter.

  10. LHC Beam Splash seen by the ATLAS detector - 7 Apr 2015 - Run 260466 - event 14046

    CERN Multimedia

    Adam Bourdarios, Claire

    2015-01-01

    Event display of one of the collimator "splash" event seen by the ATLAS experiment in LHC Run-2 , on Tuesday April the 7th : event 14046, run 260466. The collimator position is 140m in front of the ATLAS interaction point.

  11. Study on the VFD (Variable Frequency Drive) for RCP (Reactor Coolant Pump) Motors of APR1400

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jung Ha; Robert, M. Field; Kim, Tae Ryong [Department of NPP Engineering, KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

    2014-10-15

    Most industrial facilities are continually searching for ways to reduce energy costs while increasing or maintaining current production. In terms of electric motors, Variable Frequency Drive (VFD) units represent a critical opportunity for energy savings. Currently, VFDs are used on about ten (10) percent of industrial process motors, and this percentage is increasing every year. Properly applied VFDs have been documented to save as much as fifty percent of the energy consumed by certain industrial processes. Nuclear Power - Power plants in general and Nuclear Power Plants (NPPs) in particular are slow to adopt new technology. The nuclear power industry requires a nearly absolute demonstration through operating experience in other industries in which the new approach will result in a net improvement in plant reliability without any surprises. Only recently has the nuclear industry begun to adapt VFD units for large motors. Specifically, there are several examples in the Boiling Water Reactor (BWR) fleet of replacing Motor-Generator (M-G) sets with VFD units for Reactor Recirculation (RR) pump motor service. At one station, VFD units were introduced upstream of the Circulating Water (CWP) pump motors to address environmental issues. They units are taking advantage of VFD technology whose benefits include increased reliability, reduction in electrical house load, improved flow control, and reduced maintenance. RCP Application - In the case of new generation, it has been reported that the Westinghouse AP1000 will make use of VFD units for the Reactor Coolant Pump (RCP) motors.

  12. La radiothérapie du cancer de l'endomètre: expérience de l'institut national d'oncologie à propos de 52 cas

    Science.gov (United States)

    Mezouri, Imane; Berhili, Soufiane; Mouhajir, Nawal; Bellefqih, Sara; Elkacemi, Hanan; Kebdani, Tayeb; Benjaafar, Noureddine

    2016-01-01

    Le cancer de l'endomètre est le cancer gynécologique le plus fréquent en occident. Il concerne principalement les femmes ménopausées. L'objectif de notre travail est de rapporter l'expérience du service de radiothérapie à l'Institut National d'Oncologie (INO) dans la prise en charge du cancer de l'endomètre. Nous avons analysé rétrospectivement 52 cas de cancer de l'endomètre traités dans le service de radiothérapie de l'INO entre 2007 à 2009. Les données collectées à partir des dossiers médicaux de nos patientes concernaient les aspects épidémiologiques, cliniques, thérapeutiques et évolutifs de ce cancer. La médiane d’âge des patientes était de 57 ans, 87% étaient ménopausées. Le délai moyen de consultation était de six mois. Le maitre symptôme était des métrorragies chez 51 patientes. Le diagnostic histologique a été porté sur un curetage biopsique de l'endomètre dans 51% des cas. L'examen anatomopathologique a montré un adénocarcinome endométrioïde dans 92% des cas. Après le bilan, 27% des patientes étaient stade I, 30% stade II, 20% stade III et 1% stade IVA selon la classification de la Fédération Internationale de Gynécologie Obstétrique (FIGO). Après la chirurgie, 51% des patientes ont reçu une radiothérapie externe. La dose délivrée était de 46 Gray (Gy). Une curiethérapie du fond vaginal a été délivrée chez toutes les patientes. Sur le plan évolutif, 83% des patientes étaient toujours suivies en situation de bon contrôle de leur maladie, 8% ont eu une récidive locorégionale et 4% avaient des métastases à distance. Ainsi, le cancer de l'endomètre est un cancer dont le traitement repose sur la chirurgie. La radiothérapie est le traitement adjuvant principal. PMID:27279969

  13. SPECT-CT and parathyroid scintigraphy: about an imaging case in surgery; TEMP-TDM et scintigraphie parathyroidienne: a propos d'un cas de l'imagerie a la chirurgie

    Energy Technology Data Exchange (ETDEWEB)

    Venel, Y.; Rouvre, M.; Baulieu, J.L. [CHRU Bretonneau, Service de medecine nucleaire et ultrasons, 37 - Tours (France); Lardy, H. [CHRU Clocheville, service de chirurgie viscerale et plastique, 37 - Tours (France); Nivet, H. [CHRU Bretonneau, Service de nephrologie, 37 - Tours (France); Sirinelli, D. [CHRU Clocheville, service de radiologie pediatrique, 37 - Tours (France)

    2010-07-01

    Purpose: With the introduction of hybrid cameras raises the question of adaptation protocols, including parathyroid scintigraphy where several types of acquisitions are possible. The case we are going to exhibit helped to adapt our protocol by anatomical verifying during surgery with isotopic detection. Conclusions: With this case, we decided to make in routine the protocol including a MIBI injection, a cervico-thoracic image at 10 minutes and at 1 hour and 15 minutes then a coupled SPECT at 1 hour and 30 minutes. The dual isotope scintigraphy is reserved for the failures of the previous method. (N.C.)

  14. Can preoperative radiotherapy of rectal cancer convert a radical abdomino-perineal resection into a sphincter preserving surgery?; La radiotherapie preoperatoire peut-elle convertir une amputation abdominoperineale en une chirurgie conservatrice dans les adenocarcinomes du rectum?

    Energy Technology Data Exchange (ETDEWEB)

    Gerard, J.P.; Favrel, V.; Chapet, O.; Freyer, G. [Centre Hospitalier Universitaire Lyon-Sud, 69 - Pierre-Benite (France)

    1999-11-01

    Randomized trials published in the literature do not demonstrate definitively that preoperative radiotherapy increases the chance of sphincter preservation in rectal cancer. A long interval (four to six weeks) between radiotherapy and surgery may increase in selected cases of low rectal cancer the chance of sphincter preservation. Such an improvement must not lead to an increased rate of local recurrence and must preserve a good functional sphincter. Ongoing trials of dose escalation and concurrent radio-chemotherapy will provide interesting data regarding this complex question. (author)

  15. The place radiotherapy alone with respect to surgery and radiotherapy in locally advanced vulva cancers; Place de la radiotherapie seule par rapport a la chirurgie et la radiotherapie dans les cancers vulvaires localement evolues

    Energy Technology Data Exchange (ETDEWEB)

    Mansouri, S.; Naim, A.; Moukhlissi, M.; Tawfik, N.; Bouchbika, Z.; Benchekroun, N.; Jouhadi, H.; Sahraoui, S.; Benider, A. [Centre de radiotherapie-oncologie, centre hospitalier universitaire, Ibn-Rochd, Casablanca (Morocco)

    2011-10-15

    The author report a study which aimed at evaluating the place or radiotherapy associated with surgery and of radiotherapy without surgery when taking into care locally advanced vulva cancers. The study is based on 46 cases. After 24 months, different aspects, such as recurrence and survival, have been assessed. It appears that there is no survival difference without recurrences between both sets. Short communication

  16. Vliv médií na vnímání vlastního těla s důrazem na problematiku estetické chirurgie

    OpenAIRE

    Vančurová, Olga

    2010-01-01

    The bachelor thesis is related to the cosmetic surgery as a trend of the modern times. The thesis consists of theoretical and practical part. The theoretical part is divided into five chapters. The first, second and third chapter deal with the explanation of the terms plastic and cosmetic surgery, history of plastic and cosmetic surgery and the chosen procedures. The fourth chapter discusses the researches carried out in the field of cosmetic surgery, the medialized of cosmetic surgery and th...

  17. Évaluation d'outils d'assistance naviguée et robotisée à la découpe osseuse pour la chirurgie des tumeurs du pelvis

    OpenAIRE

    Cartiaux, Olivier

    2010-01-01

    This thesis originates from the research project "Sarcome" that we conducted in close collaboration with the Department of orthopaedic surgery of the UCL and the Saint-Luc University Hospital (Brussels). This project deals with the surgical treatment of malignant osseous tumors within the pelvis. Nowadays, one of the most satisfactory solutions is a large resection combined with reconstruction by massive allografts (without limb amputation). However, the conventional (freehand) bone-cutting p...

  18. Surgery of congestive heart failure - the role of computed tomography in the pre- and postsurgical diagnostic evaluation; Chirurgie der Herzinsuffizienz - Stellenwert der Computertomographie in der prae- und postoperativen Diagnostik

    Energy Technology Data Exchange (ETDEWEB)

    Lembcke, A.; Kivelitz, D.E.; Rogalla, P.; Dewey, M.; Klessen, C.; Hamm, B.; Enzweiler, C.N.H. [Inst. fuer Radiologie, Charite - Universitaetsmedizin Berlin, Charite Campus Mitte, Berlin (Germany); Dohmen, P.M.; Konertz, W.F. [Klinik fuer Kardiovaskulaere Chirurgie, Charite - Universitaetsmedizin Berlin, Charite Campus Mitte, Berlin (Germany); Wiese, T.H. [Inst. fuer Radiologie, Augusta-Kranken-Anstalt, Bochum (Germany)

    2005-07-01

    The treatment of advanced, drug resistant congestive heart failure gains in importance in the field of cardiac surgery. Cardiac imaging for preoperative assessment and follow-up focuses on the determination of ventricular volumes and function as well as on the detection of postoperative complications. Computed tomography (CT) is highly accurate irrespective of the individual patient's anatomic situation, has a low examiner dependence and short examination time, does not require an arterial vascular access and can be performed in patients with metal implants. CT is the modality of choice in the follow-up of heart transplants to detect extracardiac and cardiac complications including coronary calcifications as an early sign of transplant vasculopathy. In addition, CT visualizes the elements of mechanical assist devices and can identify their possible local cardiac and mediastinal complications CT can detect fibrolipomatous involution of the mobilized muscle flap in dynamic cardiomyoplasty and can depict fibrous reactions along the epicardial mesh implant in passive cardiac containment. Further indications include assessment of typical local postoperative complications, such as intrathoracic infection and mediastinal bleeding, intracardiac thrombus formation or pericardial effusion. CT is routinely used for evaluating bypass patency but is limited in assessing associated valve defects since it does not visualize flow. (orig.)

  19. « Hygiène », in Émile Littré, Dictionnaire de médecine, de chirurgie, de pharmacie et des sciences qui s’y rapportent

    OpenAIRE

    2013-01-01

    HYGIÈNE. s. f. [hygiene, το ύγιευόυ, de ύγιειυός, sain ; all. Gesundheitslehre, Hygiene, angl. hygiene, it. igiene, esp. higiene]. Étude des rapports sanitaires de l’homme avec le monde extérieur et des moyens de faire contribuer ces rapports à la viabilité de l’individu et de l’espèce (Arnould). L’hygiène a pour objet d’établir les règles à suivre pour le choix des moyens propres à entretenir et même à améliorer l’action normale des organes, et, par suite, à prévenir l’apparition des maladie...

  20. Back to life – Exoskeletal finger-prosthesis in a semiprofessional boxer – limitations of reconstructive surgery in symbrachydactyly [Zurück ins Leben – Epithesenversorgung bei einer semiprofessionellen Boxerin – Limitationen der rekonstruktiven Chirurgie bei der Symbrachydaktylie

    Directory of Open Access Journals (Sweden)

    Jokuszies, Andreas

    2012-04-01

    Full Text Available [english] We report an unusual case of an 18-year-old female semiprofessional boxer presenting with finger and nail deformity of the right hand after symbrachydactyly separation in childhood in whom we performed exoskeletal prosthesis for aesthetic reasons.Because of the complexity of finger deformities and limitation of surgical interventions exoskeletal prosthesis were performed.To evaluate a potential improvement of finger dexterity we performed the Nine Hole Peg Test. This is a simple and commercially available upper extremity functional assessment instrument. To evaluate the quality of life we performed the Short Form 36-Item Health Survey (, a questionnaire designed to examine a person’s perceived health status.The prosthesis provided an excellent aesthetic result and improvement of self-confidence. No functional improvement could be obtained in this special case as it is described in patients with finger amputations.Especially in women malformations of the hand and fingers are often associated with psychological impairments and social isolation. In this case and after surgery in childhood exoskeletal prostheses provide a useful option to improve the aesthetical outcome as well as quality of life.[german] Wir berichten über eine 18-jährige semiprofessionelle Boxerin mit Nagel- und Fingerdeformitäten der rechten Hand nach operativer Korrektur einer Symbrachydaktylie in der Kindheit. Zur Verbesserung des Erscheinungsbildes der rechten Hand erfolgte die Anpassung von Fingerepithesen.Die Anpassung der Epithesen erfolgte in diesem Fall aufgrund der limitierten chirurgischen Behandlungsoptionen und diente in erster Linie zur Verbesserung der Ästhetik und Steigerung des Selbstwertgefühls. Zur objektiven Messung der Fingerfertigkeit setzten wir den Nine Hole Peg Test ein. Dieser Test ist ein einfaches und kommerziell erhältliches Instrument zur funktionellen Messung im Bereich der oberen Gliedmaßen.Zur Erfassung der gesundheitsbezogenen Lebensqualität wendeten wir den SF-36 (Short Form 36-Item Health Survey an. Dieser Test erfasst acht Dimensionen der subjektiven Gesundheit.Entgegen der Beschreibung bei Patienten nach Fingeramputation konnte in diesem speziellen Fall keine Verbesserung der Fingerfertigkeit erzielt werden. Es zeigte sich jedoch eine deutlliche Verbesserung im Hinblick auf die Lebensqualität der Patientin.Insbesondere Frauen sind durch fehlgebildete Hände und Finger infolge angeborener Fehlbildungen, aber auch nach Trauma häufig psychisch stark belastet, was nicht selten zu sozialer Isolation und Beeinträchtigung des Selbstwertgefühls führt.Hier können Epithesen dazu beitragen, das ästhetische Erscheinungsbild der Hand deutlich zu verbessern und die Lebensqualität der Patienten zu steigern.

  1. Concerts & Opera

    Index Scriptorium Estoniae

    2006-01-01

    Kammerorkestri Kremerata Baltica kontserdid: 19. apr. Londonis LSO St Lukesis, 21. apr. Oxfordis Sheldonian Theatre'is, 17. apr. Aldeburghis, 20. apr. Manchesteris Bridgewater Hallis, 23. apr. Wales Millennium Centre'is, 22. apr. Edinburghis Usher Hallis

  2. Lymphome de la thyroide : à propos d’un cas et revue de littérature

    Directory of Open Access Journals (Sweden)

    L.Taali

    2016-01-01

    Full Text Available Les lymphomes thyroïdiens sont rares. Ils peuvent être primitifs, représentant moins de 5% des néoplasies thyroïdiennes et se développant dans la plupart des cas sur une affection thyroïdienne préexistante notamment une thyroïdite d'Hashimoto, ou secondaires constituant une des localisations d'un lymphome disséminé. C’est une pathologie agressive, se présentant sous forme de goitre douloureux, d'installation rapide avec des signes compressifs. La majorité sont des lymphomes non hodgkinien type B. Nous rapportons un cas de lymphome thyroïdien primitif, diagnostiqué chez une patiente admise aux urgences dans un tableau de détresse respiratoire sur un énorme goitre apparu depuis 4 mois, sans antécédents pathologiques. Le diagnostic histologique était fait suite à une biopsie chirurgicale lors de la trachéotomie. Le traitement a consisté en une chimiothérapie exclusive. L'évolution était favorable. Nous discutons, après revue de littérature, les difficultés diagnostiques et les modalités thérapeutiques, tout en précisant la place de la chirurgie.

  3. Measuring ocean waves from space; Proceedings of the Symposium, Johns Hopkins University, Laurel, MD, Apr. 15-17, 1986

    Science.gov (United States)

    Beal, Robert C. (Editor)

    1987-01-01

    Papers are presented on ocean-wave prediction; the quasi-universal form of the spectra of wind-generated gravity waves at different stages of their development; the limitations of the spectral measurements and observations of the group structure of surface waves; the effect of swell on the growth of wind wave; operational wave forecasting; ocean-wave models, and seakeeping using directional wave spectra. Consideration is given to microwave measurements of the ocean-wave directional spectra; SIR research; estimating wave energy spectra from SAR imagery, with the radar ocean-wave spectrometer, and SIR-B; the wave-measurement capabilities of the surface contour radar and the airborne oceanographic lidar; and SIR-B ocean-wave enhancement with fast-Fourier transform techniques. Topics discussed include wave-current interaction; the design and applicability of Spectrasat; the need for a global wave monitoring system; the age and source of ocean swell observed in Hurricane Josephine; and the use of satellite technology for insulin treatment.

  4. APR-246/PRIMA-1MET rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations

    OpenAIRE

    Shen, Jinfeng; van den Bogaard, Ellen H.; Kouwenhoven, Evelyn N.; Vladimir J.N. Bykov; Rinne, Tuula; Zhang, Qiang; Tjabringa, Geuranne S.; Gilissen, Christian; Van Heeringen, Simon J.; Schalkwijk, Joost; Van Bokhoven, Hans; Wiman, Klas G.; Zhou, Huiqing

    2013-01-01

    p53 and p63 share extensive sequence and structure homology. p53 is frequently mutated in cancer, whereas mutations in p63 cause developmental disorders manifested in ectodermal dysplasia, limb defects, and orofacial clefting. We have established primary adult skin keratinocytes from ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) syndrome patients with p63 mutations as an in vitro human model to study the disease mechanism in the skin of EEC patients. We show that these patien...

  5. Edgar Morin et Patrick Singaïny, Avant, pendant après le 11 janvier

    OpenAIRE

    Keslassy, Eric

    2015-01-01

    Les attentats du 7, 8 et 9 janvier 2015 ont plongé la France dans la sidération. Un état de choc qui n’est pas propice à l’analyse. Edgar Morin et Patrick Singaïny tentent néanmoins de produire une réflexion visant à comprendre ce qui s’est passé. Ils s’efforcent également de proposer des pistes pour que cela n’arrive plus (même si le livre ne formule pas réellement de pistes concrètes). Le plan de l’ouvrage est conforme à son titre. Son objectif est en effet de réfléchir – rapidement – à tro...

  6. RTE: a first assessment after one year of existence; RTE: un premier bilan apres une annee d'existence

    Energy Technology Data Exchange (ETDEWEB)

    Merlin, A. [Reseau de Transport et d' Electricite, RTE, 92 - Paris la Defense (France)

    2001-11-01

    Just over a year ago, on 1 July 2000, the manager of the French public Electricity Transport Network - RTE - entered the French electricity scene. Its creation is a result of the law of 10 February 2000 concerning the modernization and development of the electric utility, which transposes into French Law the European directive of December 1996. This law, which organizes the introduction in the market French electricity scene, foresees that the transport network manager is independent from EDF's other activities, for this network can now be used not solely by the famous operator. The entire equipment and most of the skills which contribute to the management of the public transport network were thus separated from EDF's other activities and merged into what has become RTE. This separation has been carefully prepared as soon as the principles of introduction of competition in the electricity market were established by the European directive. It was created in six month with the help of the regulatory and control authorities, the Secretary of State for Industry and the Electricity Regulation Committee (CRE). This anticipation has enabled a smooth transition and if RTE remains with EDF,it is today completely independent for managerial, accounting and financial aspects. (author)

  7. L´architecture gothique et ses enjeux nationaux en Europe apres la Seconde Guerre mondial. [Débat

    Czech Academy of Sciences Publication Activity Database

    Araguas, P.; Benešovská, Klára; Coomans, T.; Draper, P.; Espaňol, F.; Klein, B.; Sandron, D.

    Paris: Institut national d´histoire de l´art, 2007, s. 74-98. ISBN 2-200-92183-7 Institutional research plan: CEZ:AV0Z80330511 Keywords : Gothic architecture * historiography * national tradition Subject RIV: AL - Art, Architecture, Cultural Heritage

  8. The supplication: Tchernobyl, chronicles of the world after the apocalypse; La supplication: Tchernobyl, chroniques du monde apres l`apocalypse

    Energy Technology Data Exchange (ETDEWEB)

    Alexievitch, S

    1998-12-31

    This book is the result of a three year inquiry in the region of Tchernobyl (Russia) after the reactor accident, during which the author has questioned the population and collected their statement in order to reconstruct their mental feeling after the catastrophe. (J.S.)

  9. La reconstruction des édifices religieux en Basse-Normandie après la Seconde Guerre mondiale

    Directory of Open Access Journals (Sweden)

    Alain Nafilyan

    2012-04-01

    Full Text Available L’étude entreprise aux fins de protection au titre des monuments historiques a permis d’établir une synthèse globale relative à la reconstruction des édifices religieux en la replaçant dans son contexte local historique et économique. L’analyse typologique a mis en lumière un grand éclatement formel offrant diversité et tâtonnement architectural, très caractéristiques des hésitations stylistiques dans l’architecture des années 1950. L’art du vitrail trouva une place privilégiée au travers d’une recherche toujours plus plastique et subtile autour de la diffusion de la lumière. La conclusion tentera d’apporter sous forme de synthèse une contribution à une légitime interrogation : peut-on parler d’un « style » de la reconstruction ?The study begun for the purposes of legal protection in conformance with ancient memorials allowed to establish synthetic material global relative to the reconstruction of the religious buildings by replacing it in its historic and economic local context. The typological analysis revealed a big formal explosion offering very characteristic, architectural variety and experimentation of the stylistic hesitances in the architecture of the 1950s. The art of stained-glass window making found a privileged position through research always more plastic around the lighting of the church. The conclusion will try to bring in the form of synthesis a contribution to a legitimate interrogation: can we speak about a « style » of the reconstruction?

  10. Strontium-90 and cesium-137 in milk (producing districts for WHO program) (from Apr. 1981 to Nov. 1981)

    International Nuclear Information System (INIS)

    90Sr and 137Cs in milk (producing districts for WHO program) were determined. Raw milk was collected in producing districts. The results from April to November 1981 are shown in a table. (Namekawa, K.)

  11. Structure interne du piton de la Fournaise et de l'Etna d'après la tomographie sismique

    OpenAIRE

    Hirn, A.; Lépine, J.C; Sapin, M. (Michel); Laigle, M.; Nicolich, R; Gallart, J.; Lankar, V.; Nercessian, A; De Voogd, B; Charvis, Philippe; Veinante, J.L.; Verhille, J.

    1999-01-01

    Seismic approaches reveal the lithospheric structure and geodynamic contexts of Piton de la Fournaise and Etna. A set of tomographic experiments constrains their internal structures with a resolution providing insight into edifice evolution and eruptive behavior. The hotspot context of La Réunion island thus appears to differ from the Hawaiian one by a reduced plate flexure, large proportion of low velocity-density in the edifice, crustal underplating under the presently active part, which ma...

  12. Symposium on Electromagnetic Launch Technology, 6th, Univ. of Texas, Austin, Apr. 28-30, 1992, Proceedings

    Science.gov (United States)

    Grosser, Julie K.

    1993-01-01

    The present conference discusses topics in the military and commercial applications of electrical launcher systems, electromagnetic and electrothermal 'railgun' launchers, 'coilguns', armature and launcher designs, power-conditioning and energy storage systems, and launcher materials and structures and their diagnostics. Attention is given to an earth-to-orbit railgun launcher, polyphase and multiphase railguns, hypervelocity projectile design, determining the Lorentz forces in plasma armatures, pulse power generators, advanced compulsator technology, airborne-platform electric launcher applications, magnetic design for structural stiffness, current multipliers, pulse-forming network design, and cannon-caliber electromagnetic launchers.

  13. Atmospheric particle detectors. 1964-April 1980 (citations from the NTIS Data Base). Report for 1964-Apr 80

    Energy Technology Data Exchange (ETDEWEB)

    Cavagnaro, D.M.

    1980-05-01

    The cited reports cover detectors that are used primarily in air pollution and mine emission applications. Citations include monitoring site selection, applicable instrumentation, and determination of particle concentration. Excluded are studies on the chemical analysis of particles. (This updated bibliography contains 225 abstracts, 12 of which are new entries to the previous edition.)

  14. Study on thermal-hydraulic phenomena in porous media. Summarized report from 1997 Apr. to 2000 Mar

    International Nuclear Information System (INIS)

    This study deals with thermal-hydraulic phenomena in a porous blockage of a Fast Breeder Reactor. When foreign substances flow into the fuel subassembly with wire spacer, they would choke up the sub-channel and form a porous blockage. The objective of this study is to clarify the thermal-hydraulic phenomena in porous media and to develop the analytical method to predict the thermal-hydraulic field, deciding the maximum temperature on the fuel pin surface. This study is performed in cooperation with University of Tsukuba and Japan Nuclear Cycle Development Institute (JNC) from November 1997 to March 2000. This report describes the results for three years from April 1997 to March 2000. The visualization method using NaI solution as working fluid and Pyrex grass as structure was applicable to the porous media flow. When the concentration of NaI is 56.9 [wt%] in the solution, the refraction-rate corresponds to that of the Pyrex grass. The experiments to measure the velocity field inside and outside the blockage with Particle Image Velocimetry (PIV) analysis and Laser Doppler Velocimetry (LDV) were conducted. Moreover, we tried to measure the fluid temperature inside the blockage in the NaI solution, using Laser Induced Fluorescence (LIF) method. We checked the relation between the brightness of the fluorescence and solution temperature. And then, we revealed that the LIF method could be used even in the NaI solution. We also conducted the numerical analysis for the experiments. We confirmed that the calculation using the porous boby model is applicable to the analysis of the flow behavior around the porous blockage. (author)

  15. Les modalités d'adaptation après le premier choc pétrolier

    OpenAIRE

    Philippe Choffel; Philippe Cuneo; Francis Kramarz

    1988-01-01

    [spa] Las modalidades de adaptaciôn después del primer choque petrolero - Luego del primer choque petrolero, las modalidades de adaptación fueron muy diferentes según que la empresa estuviese en crecimiento, en recesión, endeudada o que fuese rentable. Una diferenciación distingue también las distintas evoluciones de acuerdo con las politicas de gestion de la mano de obra implementadas. Es asi como fueron puestas en evidencia diez categorias de evoluciones que pueden esquematizarse en tres gr...

  16. Incidence et traitement des lymphocèles après greffe rénale

    OpenAIRE

    Molteni T.

    2012-01-01

    1.1. La greffe de rein La greffe d'organes a révolutionné la médecine. De tout le temps elle a suscité les fantasmes et les rêves : la pratique est ancestrale ; elle remonte au 3ème siècle lorsque Saint Côme et Saint Damien réalisent pour la première fois une greffe de jambe de Maure sur un patient. Il faudra néanmoins attendre le 20ème siècle pour voir la transplantation se réaliser plus concrètement avec succès et se généraliser. A Vienne, en 1902, le Dr. Ulmann (1861-1937) pratique la tout...

  17. Test and evaluation of IR detectors and arrays II; Proceedings of the Meeting, Orlando, FL, Apr. 22, 23, 1992

    Science.gov (United States)

    Hoke, Forney M.

    The present conference discusses a radiometric calibration system for IR cameras, a methodology for testing IR focal-plane arrays in simulated nuclear radiation environments, process optimization for Si:As In-bumped focal-plane arrays, precise MTF measurements for focal-plane arrays, and IR focal-plane array crosstalk measurement. Also discussed are an imaging metric for IR focal-plane arrays, optical stimuli for high-volume automated testing of 2D HgCdTe focal-plane arrays, the evaluation of a solid-state photomultiplier focal-plane array for SDI, spectral effects on bulk photoconductors operated at cryogenic temperatures, and a novel technique for measuring the ionizing radiation effects in MOS transistors.

  18. Disjonction symphysaire après un accouchement par voie basse dystocique: à propos d'un cas

    Science.gov (United States)

    Laadioui, Meriem; Slimani, Wafae; Jayi, Sofia; Alaoui, Fatimazahra Fdili; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Moulay Aabdelilah

    2014-01-01

    La disjonction symphysaire est une affection rare, qui se définie par un élargissement au niveau de l'articulation inter-symphysaire estimé supérieur à 10 mm. Cette affection nécessite une prise en charge spécialisée en cas de douleurs sévères et invalidantes. Nous rapportant le cas d'une patiente présentant des douleurs pelviennes intense avec impotence du MI gauche à J2 d'un accouchement dystocique, l'examen clinique a objectivé une douleur exquise à la palpation de la symphyse pubienne. Le diagnostic a été confirmé par une radiologie du bassin de face objectivant un élargissement de la symphyse pubienne de 15 mm, la prise en charge thérapeutique a consisté en une mise sous décharge et anti-coagulation préventive avec un traitement antalgique à base de paracétamol et AINS. L’évolution était favorable. A travers notre cas, nous insisterons sur les caractéristiques de cette pathologie notamment pronostic, ce qui permettra au praticien de comprendre l'intérêt du diagnostic et prise en charge précoce de cette entité qu'elle évoquer devant toute douleurs pelviennes survenant au cours de la grossesse ou en post partum. PMID:24932344

  19. Evolution of pulmonary scintigraphy after thrombo-endarterectomy (TE); Evolution de la scintigraphie pulmonaire apres thrombo-endarteriectomie (TE)

    Energy Technology Data Exchange (ETDEWEB)

    Benada, A.; Grimon, G.; Saidi, L. [Service de Medecine Nucleaire, Hopital Antoine-Beclere, 92141 Clamart (France); Parent, F.; Jagot, J.L. [Service de Pneumologie, Hopital Antoine-Beclere, 92141 Clamart (France); Dartevelle, P. [Service de Chirurgie Thoracique, Hopital Marie Lannelongue (France); Desgrez, A.; Prigent, A. [Service de Medecine Nucleaire, Hopital Antoine-Beclere, 92141 Clamart (France)

    1997-12-31

    The TE is an alternative to lung transplant in case of post-emboli pulmonary arterial hyper blood pressure (PE-PAHBP). This work describes the changes in the pulmonary perfusion scintigraphy (PS) in the follow-up of a TE. Twenty two patients afflicted by PE-PAHBP, benefited by a TE. The pre-surgery PS have shown an average of 8.5 {+-} 2.2 hypo-perfused or non-perfused segments (min. = 5, max. = 13). Fifteen patients have had an initial post-surgery PS in the first month (average = 16 days {+-} 2.1 after TE) and all have had ulterior examination at 4.4 {+-} 2.4 months after TE (from 3 to 11 months). Finally, 9 patients have been reviewed for a tardy PS to pursue the evolution after 1 year. A table gives the initial post-surgery results as follows: amelioration of > 3 segments without aggravation - 4 patients; aggravation of > 2 segments - 9 patients; stability of discrete amelioration of scintigraphic image - 2 patients. The aggravation concerns 6.4 {+-} 2.3 segments (min. = 4, max. = 11), and is associated always to an amelioration (on 5.2 {+-} 1.9 segments, min. = 3, max. = 4) what evokes a flux flip-flop. Neither the number of pre-surgery afflicted segments, or the number of segments ameliorated are different between the patients with flux flip-flop and the others. Concerning the evolution, 7/9 patients presenting a flip-flop, have had a PS at 4 months: 5 presented a disappearance or regression in the aspect of flip-flop, and 2 presented a feeble regression in the aspect of flip-flop. The PS at less then 1 year shows that the number of abnormal segments became 6.2 {+-} 2.4; the amelioration estimated on only PS was only 2.4 {+-} 3.4 segments, what is in contradiction with the favorable evolution of clinics and hemodynamics in all the patients of this study. Concerning the tardy evolution, the amelioration of scintigraphic images can occur up to 1 year (2 patients) and 2 years (2 patients) after TE. In conclusion, the post-surgery early scintigraphic images often evoke and global aggravation, likely related to a flux flip-flop. This initial examination should not be considered as reference in judging the evolution which in our study can be continued up to 2 years

  20. Digues et polders littoraux : réflexions après la tempête Xynthia

    Directory of Open Access Journals (Sweden)

    Fernand Verger

    2011-06-01

    Full Text Available Les digues de polders littoraux comprennent plusieurs catégories : digues de mer, digues de rebras, digues dormantes et digues ruinées. Dans le marais Poitevin, la tempête Xynthia, pendant laquelle la mer a atteint un niveau exceptionnel, a submergé l'ensemble du réseau des digues. Elle a permis de prendre conscience de l'état du réseau des digues et de l'absence d'une ligne continue de digues dormantes d'un niveau suffisant pour limiter l'extension de l'inondation.Des solutions adoptées ailleurs en Europe, comme la transformation des polders en polders d'été ou la dépoldérisation n'ont pas été envisagées. La réparation à l'identique, avec un renforcement a été adoptée. D'une façon plus générale, des indices sont proposés pour aider à la gestion des polders littoraux. Ces indices doivent tenir compte de la valeur écosystémique des schorres dont la biodiversité et la productivité sont exceptionnelles. La nécessité de quantifier les enjeux – ce qui est certes difficile – apparaît d'autant plus nécessaire que la montée du niveau de la mer risque de contraindre une politique de maintien rigide du trait de côte à des investissements disproportionnés à long terme.Polder dikes coasts include several categories: sea dikes, sleeper dikes and devastated levees. In Marais Poitevin, during the storm Xynthia, the entire network of dikes has been flooded due to the exceptional level of the sea at that time. This situation has raised awareness of the status network of the current network of levees and of the lack of a continuous line of sleeper levees at a sufficient level to limit the extent of the flooding.Solutions adopted elsewhere in Europe, such as processing of the polders in summer polders or depolderization have not been considered. The decision has been taken to repair at the same and to reinforce the previous defences. In a more general way, the elaboration of indexes has been done to improve the management of coastal polders. These indexes should reflect the ecosystem value of salt marshes whose biodiversity and productivity are outstanding. Although it may be difficult, the necessity to assess the different issues is necessary indeed because the rising of the sea level may force to maintain rigid coastline at a disproportionate investment in the long term.

  1. Radviliškio miesto aprūpinimo šiluma galimybių analizė

    OpenAIRE

    Tamošiūnaitė, Jurgita

    2006-01-01

    Nowadays the majority of the companies stocking services of central heats face to the necessity to modernize the sources of the heat generation. In this Master’s Work there are analysing “Radviliškio šiluma” companies feeding the heat, boiler – houses in Radviliškis, the opportunities of the investments in order to reduce the prime cost of feeding the heat in their heat system. There are analyzing these alternatives: the basic variant, the peat burning, the cogeneration installing, and the op...

  2. RRS "Discovery" Cruise D279, 04 Apr - 10 May 2004. A Transatlantic hydrography section at 24.5N

    OpenAIRE

    Cunningham, S. A.

    2005-01-01

    The cruise report describes the acquisition and processing of transatlantic hydrographic, velocity, chemistry and other measurements made during three cruises in Spring 2004 at 24.5°N. Measurements were made from shallow water near Africa to shallow water just off Palm Springs beach on the eastern seaboard of the USA. During the principal cruise, RRS Discovery Cruise D279 (4 April to 10 May 2004), 125 full depth CTD and lowered acoustic Doppler current profiler (LADP) stations were complete...

  3. Regulation mechanisms of the FLT3-ligand after irradiation; Mecanismes de regulation du FLT3-ligand apres irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Prat-Lepesant, M

    2005-06-15

    The hematopoietic compartment is one of the most severely damaged after chemotherapy, radiotherapy or accidental irradiations. Whatever its origin, the resulting damage to the bone marrow remains difficult to evaluate. Thus, it would be of great interest to get a biological indicator of residual hematopoiesis in order to adapt the treatment to each clinical situation. Recent results indicated that the plasma Flt3 ligand concentration was increased in patients suffering from either acquired or induced aplasia, suggesting that Flt3 ligand might be useful as a biological indicator of bone marrow status. We thus followed in a mouse model as well as in several clinical situations the variations in plasma Flt3 ligand concentration, after either homogeneous or heterogeneous irradiations. These variations were correlated to the number of hematopoietic progenitors and to other parameters such as duration and depth of pancytopenia. The results indicated that the concentration of Flt3 ligand in the blood reflects the bone marrow status, and that the follow-up of plasma Flt3 ligand concentration could give predictive information about the bone marrow function and the duration and severity of pancytopenia and thrombocytopenia. Nevertheless, the clinical use of Flt3 ligand as a biological indicator of bone marrow damage require the knowledge of the mechanisms regulating the variations in plasma Flt3 ligand concentration. We thus developed a study in the mouse model. The results indicated that the variations in plasma Flt3 ligand variations were not solely due to a balance between its production by lymphoid cells and its consumption by hematopoietic cells. Moreover, we showed that T lymphocytes are not the main regulator of plasma Flt3 ligand concentration as previously suggested, and that other cell types, possibly including bone marrow stromal cells, might be strongly implicated. These results also suggest that the Flt3 ligand is a main systemic regulator of hematopoiesis, especially during induced bone marrow aplasia. (author)

  4. Synthesis report about the after-mine mission; Rapport de synthese sur la mission apres-mine

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    The French ministry of economy finances and industry has assigned the mission of evaluating the after-mine management system to the general inspection of finances and the general council of mines. The after-mine management system encompasses all procedures of coal, iron and potash mines closing down, land reclamation and environmental remedial action and site rehabilitation. This document makes first a status of the problems generated by the stoppage of mining activities: technical aspects, costs, institutional, organisational and juridical aspects, conservation of competences, international benchmarking elements and good practices implemented in foreign countries. Then, in a second part, this report presents the recommendations of the after-mine mission about the mastery of after-mine costs in agreement with the respect of the technical and social goals, with the development of the after-mine institutional system with the scheduled disappearance of Charbonnages de France and Mines de Potasses d'Alsace companies, and with the conservation of competences in the framework of the post-mine operational structure proposed by the mission. (J.S.)

  5. Trente ans après l'arbre des causes : ergonomie et bien-être au travai

    OpenAIRE

    Grosjean, Vincent

    2009-01-01

    International audience Ergonomics in France has recently begun to focus on psychosocial risks. This disciple tends to favor angles of approach different from the approaches typically found in the literature. The safety practice could benefit from this renewed approach. As far as the prevention of occupational risks is concerned, another approach of French origin has had a strong impact. This is the fault tree analysis, popularized by the french Institute for Research and Safety (INRS) sinc...

  6. Chernobyl in the French mass media 14 years after the accident; Tchernobyl dans la presse francaise 14 ans apres

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2001-02-01

    The author presents how the mass media have dealt with the fourteenth anniversary of the Chernobyl accident. Nowadays Chernobyl epitomizes the hazards of nuclear energy. Public opinion has become extremely sensitive to topics concerning human health. This sensitivity is due to previous important affairs such as the scandal of the tainted blood, the mad cow disease or the syndrome of the Balkan war. Most media have broadened the debate to the sanitary impact of nuclear activities. The hyper-mediatization of the legal case of a man prosecuting the French state for no having taken adequate measures when the radioactive cloud spread over France, has given the feeling that French authorities have always wrongly minimized the consequences of the accident. (A.C.)

  7. Superconductivity applications for infrared and microwave devices II; Proceedings of the Meeting, Orlando, FL, Apr. 4, 5, 1991

    Science.gov (United States)

    Heinen, Vernon O. (Editor); Bhasin, Kul B. (Editor)

    1991-01-01

    Topics discussed include thin-film technology, microwave transmission lines and resonators, microwave devices and circuits, infrared detectors and bolometers, and superconducting junctions. Papers are presented on possible enhancement in bolometric response using free-standing film of YBa2Cu3O(x), aging and surface instability in high-Tc superconductors, epitaxial Tl2Ba2CaCu2O8 thin films on LaAlO3 and their microwave device properties, the performance of stripline resonators using sputtered YBCO films, and a coplanar waveguide microwave filter of YBa2Cu3O7. Attention is also given to the performance characteristics of Y-Ba-Cu-O microwave superconducting detectors, high-Tc bolometer developments for planetary missions, infrared detectors from YBaCuO thin films, high-temperature superconductor junction technology, and submillimeter receiver components using superconducting tunnel junctions.

  8. Superconductivity applications for infrared and microwave devices; Proceedings of the Meeting, Orlando, FL, Apr. 19, 20, 1990

    Science.gov (United States)

    Bhasin, Kul B. (Editor); Heinen, Vernon O. (Editor)

    1990-01-01

    Various papers on superconductivity applications for IR and microwave devices are presented. The individual topics addressed include: pulsed laser deposition of Tl-Ca-Ba-Cu-O films, patterning of high-Tc superconducting thin films on Si substrates, IR spectra and the energy gap in thin film YBa2Cu3O(7-delta), high-temperature superconducting thin film microwave circuits, novel filter implementation utilizing HTS materials, high-temperature superconductor antenna investigations, high-Tc superconducting IR detectors, high-Tc superconducting IR detectors from Y-Ba-Cu-O thin films, Y-Ba-Cu0-O thin films as high-speed IR detectors, fabrication of a high-Tc superconducting bolometer, transition-edge microbolometer, photoresponse of YBa2Cu3O(7-delta) granular and epitaxial superconducting thin films, fast IR response of YBCO thin films, kinetic inductance effects in high-Tc microstrip circuits at microwave frequencies.

  9. Western Gulf of Mexico April 1994 Ocean Currents, Geographic NAD83, MMS (1999) [ocean_currents_wgom_Apr_MMS_1994

    Data.gov (United States)

    Louisiana Geographic Information Center — This is one data set of a data package consisting of thirteen point data sets that have as attributes the direction and velocity of ocean currents in the western...

  10. Eastern Gulf of Mexico April 1997 Ocean Currents, Geographic NAD83, MMS (1999) [ocean_currents_egom_Apr_MMS_1997

    Data.gov (United States)

    Louisiana Geographic Information Center — This is one data set of a data package consisting of thirteen point data sets that have as attributes the direction and velocity of ocean currents in the 'eastern'...

  11. Après le spectacle : les impacts psychosociaux de consommation de pornographie homosexuelle masculine chez les hommes gais

    Directory of Open Access Journals (Sweden)

    SIMON CORNEAU

    2010-01-01

    Full Text Available Cette recherche qualitative exploratoire vise à mettre à jour les impacts psychosociaux possibles de consommation de pornographie homosexuelle masculine à travers les discours de 20 usagers gais de Toronto (Canada. La consommation de pornographie semble plus acceptée et normalisée chez les hommes gais que chez les hommes hétérosexuels. Une telle consommation peut avoir une incidence sur certains aspects de la santé sexuelle et de la santé mentale. L'analyse thématique du corpus de nos données nous révèle que les impacts peuvent se faire sentir au niveau de l'apprentissage, de l'édification de la fantasmatique, de la validation de la sexualité entre hommes, de l'ingérence dans la vie sexuelle et enfin, sur l'habituation et sur l'image de soi/image corporelle. À l'aide de l’analyse critique de discours, nous avons pu documenter les discours sociaux plus larges en jeu dans les récits des usagers et voir de quelle façon ils se positionnent à l'intérieur de ces mêmes discours.

  12. Le deuil des conjoints après un cancer : entre évaluation et expérience subjective

    OpenAIRE

    Fasse, Léonor,

    2013-01-01

    In 2011, in France, more than 147 525 men and women died through cancer. This disease doesn’t affect only the oldest: 41 000 untimely deaths, before 65 years, are caused by cancer (FRANCIM, InVS, CIRC). All these persons were supposed to live with a partner. Faced with the patient’s death, more or less sustainable psychological, physical or social upheavals will affect the spouse.The cancer patient’s relatives and family constitute one of the patient’s main sources of support throughout the d...

  13. Ce qu'on en dit après - le Currency Board argentin et sa fin tragique

    OpenAIRE

    Sgard, Jérôme

    2004-01-01

    L'Argentine a mené entre 1991 et 2001 une des expériences de currency board les plus remarquables de la période moderne. Comment rendre compte de cette expérience, prise dans son ensemble ? Qu'apprend-elle sur les avantages et les inconvénients des currency board ? Comment expliquer son échec final et quelles conclusions plus générales en tirer ? Telles sont les questions auxquelles cet article souhaite apporter des éléments de réponse. Pour cela, l'auteur commence par rappeler les principaux...

  14. L'après guerre civile : les étapes de la réconciliation nationale

    OpenAIRE

    Martinez, Luis

    2000-01-01

    Entre 1993 et 1997, trois défis menaçaient le régime algérien : la mise en place d'une alternative politique regroupée sous la communauté catholique de Sant' Egidio à Rome, le développement d'une guérilla islamiste et la faillite financière de l'Etat. En juin 1997, à l'exception du FIS, les partis qui composaient le "front du refus" participent aux élections législatives et acceptent de siéger à l'Assemblée nationale (...).

  15. Ahmedabad après le séisme : l'État dépassé

    OpenAIRE

    Jaffrelot, Christophe

    2001-01-01

    Ahmedabad, le 11 février 2001. Le bus assurant la navette entre la gare et l’hôtel Cama porte encore sur le pare-brise l’écriteau indiquant qu’il a été réquisitionné par une ONG britannique pour les opérations de secours. À l’hôtel, où d’énormes fissures lézardent les plafonds et les murs, les dernières équipes de médecins étrangers occupent, comme les autres (rares) pensionnaires, le quatrième et dernier étage – une précaution élémentaire en cas de réplique, explique le réceptionniste (...)....

  16. Représentation de l'espace gaulois d'après Grégoire de Tours

    Directory of Open Access Journals (Sweden)

    Xavier Rodier

    2004-12-01

    Full Text Available The systematic mapping of place names in Gaul from the collected works of Gregory of Tours (late 6th century stimulated some thoughts on the modern representation of space for this period. Different cartographic tools were employed to transform the distribution of location points into a spatial image. Lastly, the proposed virtual map provides the possibility to travel around this created space and explore it. While this virtual map generated new perspectives regarding the database of Gregory, it also showed the limited use one can make of this information regarding space.

  17. Alloy phase stability and design; Proceedings of the Symposium, San Francisco, CA, Apr. 18-20, 1990

    International Nuclear Information System (INIS)

    The present conference on phase stability and design in alloys encompasses the first principles and theories of phase stability, experimental results in relation to phase-stability theory, the mechanical properties of alloys, the alloy design of ordered intermetallics, the designs of nickel-based superalloys, steels, and Al-based alloys. Specific issues addressed include the phase stability and ground-state properties of the Al-Ti system, electronic structure and phase-stability properties in Al-Li alloys, the thermodynamic stability of ordered intermetallic compound phases, phase stability in binary Ti-Al, and photoemission from ordered and disordered Cu3Au. Also addressed are the effects of scandium on the phase stability of Al3Nb and Al3Zr, the deformation and fracture behavior of TiAl, the design of (L1 sub 2)-type Ni3Si intermetallics, alloy phase-stability requirements in single-crystal superalloys, and quasicrystalline phase decomposition in a rapidly solidified Al-Fe-V-Si alloy

  18. Radionuclide lymphoscintigraphy in limb edemas; La lymphoscintigraphie dans la pathologie lymphatique des membres: reflexions apres 20 ans d`utilisation

    Energy Technology Data Exchange (ETDEWEB)

    Pecking, A.P. [Centre Rene Huguenin, 92 - Saint-Cloud (France); Cluzan, R.V. [Hopital Cognacq-Jay, 75 - Paris (France)

    1997-12-31

    Indirect radionuclide lymphoscintigraphy is a safe, non-invasive and physiological method for the assessment of the limb lymphatic system. Colloids as antimony or rhenium sulphide labeled with 99m technetium have been widely used for morphological studies. Quantitative studies involving a continuous count rate monitoring of the injection sites followed by a computer analysis of dynamic image sequences have been a new promising step for an objective measurement of the peripheral lymphatic function. The injection site is always bilateral on the first web space of either the hand or the foot using a small volume (<0.2 mL) of the radiocolloid. This method has been validated on 30 young healthy volunteers and normal values established from a group of 125 upper and 141 lower limbs (normal subjects). The normal results showed a slight but continuous decrease in lymphatic function depending on the age of the subject. In pathological situations, we observed dysfunction of the lymphatic system in pure lymphoedemas or so-called lympho-venous edemas as demonstrated on the 1,182 upper and 2,463 lower limbs tested. The radionuclide lymphoscintigraphy may be helpful in cases of unilateral swollen limbs demonstrating a lymphatic dysfunction on a clinically normal contralateral limb at the first stage of a distal edema which appears within a few weeks or days, in a transient edema phase when normal status and oedema alternate. The lymphoscintigraphy gives objective and reproducible parameters necessary to assess the lymphatic variation under therapy (decongestive physiotherapy, surgery, drugs) and may be useful in the selection of new lympho-tonic treatments. This method is only reflecting the lymphatic function and is unable to appreciate the total lymphatic flow of the limb. Its results only reflect what happens at the injection site and it may be necessary to add a second test using a proximal injection in order to assess the occurrence of lymph nodes not visualized by the general method. (authors). 18 refs.

  19. Mettre en oeuvre une GMAO maintenance industrielle, service après-vente, maintenance immobilière

    CERN Document Server

    Frédéric, Marc

    2003-01-01

    Pour les entreprises, l'utilisation d'un progiciel de GMAO [Gestion de la Maintenance Assistée par Ordinateur] est devenue un outil incontournable de gestion technico-budgétaire des activités de maintenance. Cependant, sans une bonne prise en compte des besoins techniques, financiers et humains, l'implantation d'un logiciel de GMAO risque de conduire à des échecs coûteux et aux effets irréversibles. Cet ouvrage très pratique propose donc de passer en revue toutes les étapes de la mise en œuvre d'une GMAO, de l'analyse des besoins jusqu'aux impacts organisationnels, en donnant tous les éléments permettant la réussite d'un projet d'implantation de GMAO.

  20. Gesellschaft fuer angewandte Mathematik und Mechanik, Scientific Annual Meeting, Technische Universitaet Wien, Vienna, Austria, Apr. 5-9, 1988, Reports

    Science.gov (United States)

    Various papers on applied mathematics and mechanics are presented. The general topics considered include: numerical treatment of implicit differential equations and differential algebraic systems; software for scientific calculation; structural analysis and simulation; stochastic methods; biomathematics; interpolation and approximation; quadrature; optimization; methods in operations research; enclosures for linear and nonlinear equations; enclosures for functional equations; ordinary differential equations and dynamical systems; ordinary differential and difference equations; and numerics of stiff differential equations. Also addressed are: waves, analysis, applications, and numerics in partial differential equations; large systems of linear equations; multigrid methods; iterative processes in applied function theory; discrete mathematics and informatics; fundamentals, special methods, and shells in FEM; beams and special applications; fundamentals, solid mechanics, and fluid mechanics in BEM.