WorldWideScience

Sample records for approval reference number

  1. 8 CFR 207.6 - Control over approved refugee numbers.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Control over approved refugee numbers. 207... ADMISSION OF REFUGEES § 207.6 Control over approved refugee numbers. Current numerical accounting of approved refugees is maintained for each special group designated by the President. As refugee status...

  2. 75 FR 34150 - Renewal of Approved Information Collection, OMB Control Number 1004-0168

    Science.gov (United States)

    2010-06-16

    ... Bureau of Land Management Renewal of Approved Information Collection, OMB Control Number 1004-0168 AGENCY... intention to request that the Office of Management and Budget (OMB) renew its approval to collect information from private landowners in western Oregon who are authorized to transport timber over...

  3. Number of Drilling Permits Approved by Fiscal Year on Federal Lands by BLM

    Data.gov (United States)

    Bureau of Land Management, Department of the Interior — This table contains the total number of Applications for Permit to Drill (APDs) by state approved by the BLM each fiscal year. Oil and gas operators may not begin...

  4. Number of patients studied prior to approval of new medicines

    DEFF Research Database (Denmark)

    Duijnhoven, Ruben G; Straus, Sabine M J M; Raine, June M;

    2013-01-01

    medicines and 438 (IQR 132-915) for orphan medicines. On average, chronic medication was studied in a larger number of patients (median 2,338, IQR 1,462-4,135) than medication for intermediate (878, IQR 513-1,559) or short-term use (1,315, IQR 609-2,420). Safety and efficacy of chronic use was studied...... in fewer than 1,000 patients for at least 6 and 12 mo in 46.4% and 58.3% of new medicines, respectively. Among the 84 medicines intended for chronic use, 68 (82.1%) met the guideline recommendations for 6-mo use (at least 300 participants studied for 6 mo and at least 1,000 participants studied for any...... length of time), whereas 67 (79.8%) of the medicines met the criteria for 12-mo patient exposure (at least 100 participants studied for 12 mo). CONCLUSIONS: For medicines intended for chronic use, the number of patients studied before marketing is insufficient to evaluate safety and long-term efficacy...

  5. Animal Science. Instructor Guide [and] Student Reference. Volume 28, Number 3 [and] Volume 28, Number 4.

    Science.gov (United States)

    Baker, Andy; And Others

    This instructor guide and the corresponding student reference contain 4 units that include 30 lessons for a course in animal science for 11th- and 12th-grade agriculture science students. The units cover nutrition, genetics, reproduction, and animal health. The instructor's guide contains the following: objectives, competencies, motivational…

  6. Equine Science. Instructor Guide [and] Student Reference. Volume 27, Number 4 [and] Volume 27, Number 5.

    Science.gov (United States)

    Leffert, Kenneth L.; And Others

    This instructor guide and the corresponding student reference contain 10 lessons to enhance an Agricultural Science I course for grade 9. The lessons cover the following topics: introduction, psychology and handling, conformation and selection, genetics and reproduction, herd health, hoof care, nutrition, equipment and facilities, handling horses,…

  7. Detailed Chemical Kinetic Reaction Mechanisms for Primary Reference Fuels for Diesel Cetane Number and Spark-Ignition Octane Number

    Energy Technology Data Exchange (ETDEWEB)

    Westbrook, C K; Pitz, W J; Mehl, M; Curran, H J

    2010-03-03

    For the first time, a detailed chemical kinetic reaction mechanism is developed for primary reference fuel mixtures of n-hexadecane and 2,2,4,4,6,8,8-heptamethyl nonane for diesel cetane ratings. The mechanisms are constructed using existing rules for reaction pathways and rate expressions developed previously for the primary reference fuels for gasoline octane ratings, n-heptane and iso-octane. These reaction mechanisms are validated by comparisons between computed and experimental results for shock tube ignition and for oxidation under jet-stirred reactor conditions. The combined kinetic reaction mechanism contains the submechanisms for the primary reference fuels for diesel cetane ratings and submechanisms for the primary reference fuels for gasoline octane ratings, all in one integrated large kinetic reaction mechanism. Representative applications of this mechanism to two test problems are presented, one describing fuel/air autoignition variations with changes in fuel cetane numbers, and the other describing fuel combustion in a jet-stirred reactor environment with the fuel varying from pure 2,2,4,4,6,8,8-heptamethyl nonane (Cetane number of 15) to pure n-hexadecane (Cetane number of 100). The final reaction mechanism for the primary reference fuels for diesel fuel and gasoline is available on the web.

  8. Selection of Suitable Endogenous Reference Genes for Relative Copy Number Detection in Sugarcane

    Directory of Open Access Journals (Sweden)

    Bantong Xue

    2014-05-01

    Full Text Available Transgene copy number has a great impact on the expression level and stability of exogenous gene in transgenic plants. Proper selection of endogenous reference genes is necessary for detection of genetic components in genetically modification (GM crops by quantitative real-time PCR (qPCR or by qualitative PCR approach, especially in sugarcane with polyploid and aneuploid genomic structure. qPCR technique has been widely accepted as an accurate, time-saving method on determination of copy numbers in transgenic plants and on detection of genetically modified plants to meet the regulatory and legislative requirement. In this study, to find a suitable endogenous reference gene and its real-time PCR assay for sugarcane (Saccharum spp. hybrids DNA content quantification, we evaluated a set of potential “single copy” genes including P4H, APRT, ENOL, CYC, TST and PRR, through qualitative PCR and absolute quantitative PCR. Based on copy number comparisons among different sugarcane genotypes, including five S. officinarum, one S. spontaneum and two S. spp. hybrids, these endogenous genes fell into three groups: ENOL-3—high copy number group, TST-1 and PRR-1—medium copy number group, P4H-1, APRT-2 and CYC-2—low copy number group. Among these tested genes, P4H, APRT and CYC were the most stable, while ENOL and TST were the least stable across different sugarcane genotypes. Therefore, three primer pairs of P4H-3, APRT-2 and CYC-2 were then selected as the suitable reference gene primer pairs for sugarcane. The test of multi-target reference genes revealed that the APRT gene was a specific amplicon, suggesting this gene is the most suitable to be used as an endogenous reference target for sugarcane DNA content quantification. These results should be helpful for establishing accurate and reliable qualitative and quantitative PCR analysis of GM sugarcane.

  9. Number of Patients Studied Prior to Approval of New Medicines: A Database Analysis

    NARCIS (Netherlands)

    Duijnhoven, R.G.; Straus, S.M.J.M.; Raine, J.M.; de Boer, A.; Hoes, A.W.; De Bruin, M.L.

    2013-01-01

    Background: At the time of approval of a new medicine, there are few long-term data on the medicine’s benefit–risk balance. Clinical trials are designed to demonstrate efficacy, but have major limitations with regard to safety in terms of patient exposure and length of follow-up. This study of the n

  10. Number of Patients Studied Prior to Approval of New Medicines: A Database Analysis

    NARCIS (Netherlands)

    R.G. Duijnhoven (Ruben); S.M.J.M. Straus (Sabine); J.W. Raine (John); A.C. de Boer (Anthonius); A.W. Hoes (Arno); M.L. de Bruin (Marie)

    2013-01-01

    textabstractBackground: At the time of approval of a new medicine, there are few long-term data on the medicine's benefit-risk balance. Clinical trials are designed to demonstrate efficacy, but have major limitations with regard to safety in terms of patient exposure and length of follow-up. This st

  11. Practical and fast quantum random number generation based on photon arrival time relative to external reference

    Energy Technology Data Exchange (ETDEWEB)

    Nie, You-Qi; Zhang, Jun, E-mail: zhangjun@ustc.edu.cn; Pan, Jian-Wei [Hefei National Laboratory for Physical Sciences at the Microscale and Department of Modern Physics, University of Science and Technology of China, Hefei, Anhui 230026 (China); Synergetic Innovation Center of Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, Anhui 230026 (China); Zhang, Hong-Fei; Wang, Jian [Hefei National Laboratory for Physical Sciences at the Microscale and Department of Modern Physics, University of Science and Technology of China, Hefei, Anhui 230026 (China); Zhang, Zhen; Ma, Xiongfeng [Center for Quantum Information, Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing 100084 (China)

    2014-02-03

    We present a practical high-speed quantum random number generator, where the timing of single-photon detection relative to an external time reference is measured as the raw data. The bias of the raw data can be substantially reduced compared with the previous realizations. The raw random bit rate of our generator can reach 109 Mbps. We develop a model for the generator and evaluate the min-entropy of the raw data. Toeplitz matrix hashing is applied for randomness extraction, after which the final random bits are able to pass the standard randomness tests.

  12. Practical and fast quantum random number generation based on photon arrival time relative to external reference

    Science.gov (United States)

    Nie, You-Qi; Zhang, Hong-Fei; Zhang, Zhen; Wang, Jian; Ma, Xiongfeng; Zhang, Jun; Pan, Jian-Wei

    2014-02-01

    We present a practical high-speed quantum random number generator, where the timing of single-photon detection relative to an external time reference is measured as the raw data. The bias of the raw data can be substantially reduced compared with the previous realizations. The raw random bit rate of our generator can reach 109 Mbps. We develop a model for the generator and evaluate the min-entropy of the raw data. Toeplitz matrix hashing is applied for randomness extraction, after which the final random bits are able to pass the standard randomness tests.

  13. 78 FR 77449 - GSA Approves Renewal of North American Numbering Council Charter Through September 20, 2015

    Science.gov (United States)

    2013-12-23

    ... public cannot be overstated. Telephone numbers are the means by which consumers gain access to, and reap the benefits of, the public switched telephone network. The Council's recommendations to the... is the telephone numbering plan for the United States and its territories, Canada, Bermuda, and...

  14. Entomology for Agricultural Science II Core Curriculum. Instructor Guide, Volume 23, Number 2, and Student Reference, Volume 23, Number 3.

    Science.gov (United States)

    DeFelice, Karen L.

    This unit is a basic introduction to entomology. The instructor guide and the corresponding student reference contain seven lessons: (1) introduction to entomology; (2) insect collection; (3) insect identification; (4) methods of control; (5) chemical control measures; (6) safe use of insecticides; and (7) integrated pest management. Students…

  15. Introduction to Animal Nutrition. Instructor Guide [and] Student Reference. Volume 28, Number 7 [and] Volume 28, Number 8.

    Science.gov (United States)

    Peiter, Andrea; And Others

    This instructor guide and the corresponding student reference contain five lessons about animal science for inclusion in Vocational Instructional Management System (VIMS) agricultural education courses. The lessons cover these topics: the monogastric digestive system, the ruminant digestive system, the importance of meeting nutritional needs, how…

  16. Introduction to Animal Reproduction. Instructor Guide [and] Student Reference. Volume 28, Number 5 [and] Volume 28, Number 6.

    Science.gov (United States)

    Peiter, Andrea; And Others

    This instructor guide and the corresponding student reference contain seven lessons about animal reproduction for inclusion in Vocational Instructional Management System (VIMS) agricultural education courses. The lessons cover the following topics: the male and female reproductive systems, puberty and the estrous cycle, conception and gestation,…

  17. 76 FR 68759 - GSA Approves Renewal of North American Numbering Council Charter Through September 23, 2013

    Science.gov (United States)

    2011-11-07

    ... telecommunications industry and to the American public cannot be overstated. Telephone numbers are the means by which consumers gain access to, and reap the benefits of, the public switched telephone network. The...

  18. Plant Science. Instructor Guide [and] Student Reference. Volume 24, Numbers 3 and 4.

    Science.gov (United States)

    Humphrey, John Kevin

    This document consists of two separately published guides for a course on plant science: an instructor's guide and a student's reference manual. Each part consists of eight lessons and cover the following topics: (1) importance of plants; (2) classification of plants; (3) plant growth factors; (4) weeds, diseases, insects; (5) germination; (6)…

  19. A novel SNP analysis method to detect copy number alterations with an unbiased reference signal directly from tumor samples

    Directory of Open Access Journals (Sweden)

    LaFramboise William A

    2011-01-01

    Full Text Available Abstract Background Genomic instability in cancer leads to abnormal genome copy number alterations (CNA as a mechanism underlying tumorigenesis. Using microarrays and other technologies, tumor CNA are detected by comparing tumor sample CN to normal reference sample CN. While advances in microarray technology have improved detection of copy number alterations, the increase in the number of measured signals, noise from array probes, variations in signal-to-noise ratio across batches and disparity across laboratories leads to significant limitations for the accurate identification of CNA regions when comparing tumor and normal samples. Methods To address these limitations, we designed a novel "Virtual Normal" algorithm (VN, which allowed for construction of an unbiased reference signal directly from test samples within an experiment using any publicly available normal reference set as a baseline thus eliminating the need for an in-lab normal reference set. Results The algorithm was tested using an optimal, paired tumor/normal data set as well as previously uncharacterized pediatric malignant gliomas for which a normal reference set was not available. Using Affymetrix 250K Sty microarrays, we demonstrated improved signal-to-noise ratio and detected significant copy number alterations using the VN algorithm that were validated by independent PCR analysis of the target CNA regions. Conclusions We developed and validated an algorithm to provide a virtual normal reference signal directly from tumor samples and minimize noise in the derivation of the raw CN signal. The algorithm reduces the variability of assays performed across different reagent and array batches, methods of sample preservation, multiple personnel, and among different laboratories. This approach may be valuable when matched normal samples are unavailable or the paired normal specimens have been subjected to variations in methods of preservation.

  20. Chromosome number evolution in Hymenophyllum (Hymenophyllaceae), with special reference to the subgenus Hymenophyllum.

    Science.gov (United States)

    Hennequin, Sabine; Ebihara, Atsushi; Dubuisson, Jean-Yves; Schneider, Harald

    2010-04-01

    With about 100 species distributed worldwide, Hymenophyllum subg. Hymenophyllum is the largest subgenus of filmy ferns. It also displays morphological disparity and extreme chromosome numbers variation, with n=11, 12, 13, 14, 18, 21, 22, 26, 28, and 34. We use DNA sequences from the genes rbcL, part of accD, rps4, and the intergenic spacers rbcL-accD, rps4-trnS, and trnG-trnR to infer relationships within Hymenophyllum, with a focus on this subgenus. In the subgenus Hymenophyllum, two main clades are retrieved together with several minor clades whose placement within the subgenus remains ambiguous. We then investigate the evolution of chromosome numbers in the genus and the subgenus, using a maximum likelihood approach taking into account phylogenetic uncertainty. We provide evidence that Hymenophyllum experienced descending aneuploidy during its evolutionary history, especially within the subgenus Hymenophyllum. Reduction in chromosome numbers is particularly extreme in one clade of the subgenus, with the lowest number reported for homosporous ferns. In addition, this group of species displays a high instability in its chromosome number. Both the reduction and the instability in chromosome number may coincide with the distribution of these species in either temperate areas or at high elevations.

  1. Some Numbers behind Canada's Decision to Adopt an Orphan Drug Policy: US Orphan Drug Approvals in Canada, 1997-2012.

    Science.gov (United States)

    Herder, Matthew; Krahn, Timothy Mark

    2016-05-01

    We examined whether access to US-approved orphan drugs in Canada has changed between 1997 (when Canada chose not to adopt an orphan drug policy) and 2012 (when Canada reversed its policy decision). Specifically, we looked at two dimensions of access to US-approved orphan drugs in Canada: (1) regulatory access; and (2) temporal access. Whereas only 63% of US-approved orphan drugs were granted regulatory approval in 1997, we found that regulatory access to US-approved orphan drugs in Canada increased to 74% between 1997 and 2012. However, temporal access to orphan drugs is slower in Canada: in a head-on comparison of 40 matched drugs, only two were submitted and four were approved first in Canada; moreover, the mean review time in Canada (423 days) was longer than that in the US (mean = 341 days), a statistically significant difference (t[39] = 2.04, p = 0.048). These results raise questions about what motivated Canada's apparent shift in orphan drug policy.

  2. What factors explain the number of physical therapy treatment sessions in patients referred with low back pain; a multilevel analysis

    Directory of Open Access Journals (Sweden)

    Dekker Joost

    2005-11-01

    Full Text Available Abstract Background It is well-known that the number of physical therapy treatment sessions varies over treatment episodes. Information is lacking, however, on the source and explanation of the variation. The purposes of the current study are: 1 to determine how the variance in the number of physical therapy treatment sessions in patients with non-specific low back pain (LBP in the Netherlands is distributed over patient level, therapist level and practice level; and 2 to determine the factors that explain the variance. Methods Data were used from a national registration network on physical therapy. Our database contained information on 1,733 patients referred with LBP, treated by 97 therapists working in 41 practices. The variation in the number of treatment sessions was investigated by means of multilevel regression analyses. Results Eighty-eight per cent of the variation in the number of treatment sessions for patients with LBP is located at patient level and seven per cent is located at practice level. It was possible to explain thirteen per cent of all variance. The duration of the complaint, prior therapy, and the patients' age and gender in particular are related to the number of physical therapy treatment sessions. Conclusion Our results suggest that the number of physical therapy treatment sessions in patients with LBP mainly depends on patient characteristics. More variation needs to be explained, however, to improve the transparency of care. Future research should examine the contribution of psychosocial factors, baseline disability, and the ability to learn motor behavior as possible factors in the variation in treatment sessions.

  3. The importance of selecting the appropriate reference genes for quantitative real time PCR as illustrated using colon cancer cells and tissue [version 2; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Catríona M. Dowling

    2016-03-01

    Full Text Available Quantitative real-time reverse-transcription polymerase chain reaction (RT-qPCR remains the most sensitive technique for nucleic acid quantification. Its popularity is reflected in the remarkable number of publications reporting RT-qPCR data. Careful normalisation within RT-qPCR studies is imperative to ensure accurate quantification of mRNA levels. This is commonly achieved through the use of reference genes as an internal control to normalise the mRNA levels between different samples. The selection of appropriate reference genes can be a challenge as transcript levels vary with physiology, pathology and development, making the information within the transcriptome flexible and variable. In this study, we examined the variation in expression of a panel of nine candidate reference genes in HCT116 and HT29 2-dimensional and 3-dimensional cultures, as well as in normal and cancerous colon tissue. Using normfinder we identified the top three most stable genes for all conditions. Further to this we compared the change in expression of a selection of PKC coding genes when the data was normalised to one reference gene and three reference genes. Here we demonstrated that there is a variation in the fold changes obtained dependent on the number of reference genes used. As well as this, we highlight important considerations namely; assay efficiency tests, inhibition tests and RNA assessment which should also be implemented into all RT-qPCR studies. All this data combined demonstrates the need for careful experimental design in RT-qPCR studies to help eliminate false interpretation and reporting of results.

  4. The importance of selecting the appropriate reference genes for quantitative real time PCR as illustrated using colon cancer cells and tissue [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Catríona M Dowling

    2016-01-01

    Full Text Available Quantitative real-time reverse-transcription polymerase chain reaction (RT-qPCR remains the most sensitive technique for nucleic acid quantification. Its popularity is reflected in the remarkable number of publications reporting RT-qPCR data. Careful normalisation within RT-qPCR studies is imperative to ensure accurate quantification of mRNA levels. This is commonly achieved through the use of reference genes as an internal control to normalise the mRNA levels between different samples. The selection of appropriate reference genes can be a challenge as transcript levels vary with physiology, pathology and development, making the information within the transcriptome flexible and variable. In this study, we examined the variation in expression of a panel of nine candidate reference genes in HCT116 and HT29 2-dimensional and 3-dimensional cultures, as well as in normal and cancerous colon tissue. Using normfinder we identified the top three most stable genes for all conditions. Further to this we compared the change in expression of a selection of PKC coding genes when the data was normalised to one reference gene and three reference genes. Here we demonstrated that there is a variation in the fold changes obtained dependent on the number of reference genes used. As well as this, we highlight important considerations namely; assay efficiency tests, inhibition tests and RNA assessment which should also be implemented into all RT-qPCR studies. All this data combined demonstrates the need for careful experimental design in RT-qPCR studies to help eliminate false interpretation and reporting of results.

  5. Phase-reference monitoring in coherent-state discrimination assisted by a photon-number resolving detector

    Science.gov (United States)

    Bina, Matteo; Allevi, Alessia; Bondani, Maria; Olivares, Stefano

    2016-05-01

    Phase estimation represents a crucial challenge in many fields of Physics, ranging from Quantum Metrology to Quantum Information Processing. This task is usually pursued by means of interferometric schemes, in which the choice of the input states and of the detection apparatus is aimed at minimizing the uncertainty in the estimation of the relative phase between the inputs. State discrimination protocols in communication channels with coherent states also require the monitoring of the optical phase. Therefore, the problem of phase estimation is relevant to face the issue of coherent states discrimination. Here we consider a quasi-optimal Kennedy-like receiver, based on the interference of two coherent signals, to be discriminated, with a reference local oscillator. By means of the Bayesian processing of a small amount of data drawn from the outputs of the shot-by-shot discrimination protocol, we demonstrate the achievement of the minimum uncertainty in phase estimation, also in the presence of uniform phase noise. Moreover, we show that the use of photon-number resolving detectors in the receiver improves the phase-estimation strategy, especially with respect to the usually employed on/off detectors. From the experimental point of view, this comparison is realized by employing hybrid photodetectors.

  6. Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance [version 1; referees: 5 approved

    Directory of Open Access Journals (Sweden)

    Marie-Claude N. Laffitte

    2016-09-01

    Full Text Available Leishmania has a plastic genome, and drug pressure can select for gene copy number variation (CNV. CNVs can apply either to whole chromosomes, leading to aneuploidy, or to specific genomic regions. For the latter, the amplification of chromosomal regions occurs at the level of homologous direct or inverted repeated sequences leading to extrachromosomal circular or linear amplified DNAs. This ability of Leishmania to respond to drug pressure by CNVs has led to the development of genomic screens such as Cos-Seq, which has the potential of expediting the discovery of drug targets for novel promising drug candidates.

  7. Effect of inlet-air humidity, temperature, pressure, and reference Mach number on the formation of oxides of nitrogen in a gas turbine combustor

    Science.gov (United States)

    Marchionna, N. R.; Diehl, L. A.; Trout, A. M.

    1973-01-01

    Tests were conducted to determine the effect of inlet air humidity on the formation of oxides of nitrogen (NOx) from a gas turbine combustor. Combustor inlet air temperature ranged from 506 K (450 F) to 838 K (1050 F). The tests were primarily run at a constant pressure of 6 atmospheres and reference Mach number of 0.065. The NOx emission index was found to decrease with increasing inlet air humidity at a constant exponential rate: NOx = NOx0e-19H (where H is the humidity and the subscript 0 denotes the value at zero humidity). the emission index increased exponentially with increasing normalized inlet air temperature to the 1.14 power. Additional tests made to determine the effect of pressure and reference Mach number on NOx showed that the NOx emission index varies directly with pressure to the 0.5 power and inversely with reference Mach number.

  8. Introduction to Agricultural Business Unit. Student Reference for Agricultural Science I Core Curriculum. [Volume 19, Number 20.

    Science.gov (United States)

    Timko, Joseph J.; Birkenholz, Robert J.

    This student reference on agricultural business, designed to accompany the lessons outlined in the 1984 instructor's guide, "Introduction to Agricultural Business," has seven lessons: (1) introduction to agribusiness; (2) careers in agribusiness; (3) agribusiness in the community; (4) the role of the employee in an agribusiness; (5)…

  9. Searching for Information on Tests: Reference Sources and a Search Strategy. Iowa Testing Programs Occasional Papers Number 38.

    Science.gov (United States)

    Jordan, Robert P.

    Research methodologies in several of the social sciences require the use of tests. When assisting social science researchers who seek information on tests, reference librarians do not, themselves, always have direct access to the instruments. Librarians should not only have the knowledge that various print and electronic database resources are…

  10. What factors explain the number of physical therapy treatment sessions in patients referred with low back pain; a multilevel analysis

    NARCIS (Netherlands)

    Swinkels, I.C.S.; Wimmers, R.H.; Groenewegen, P.P.; Bosch, van den W.J.; Dekker, J.; Ende, van den C.H.M.

    2005-01-01

    BACKGROUND: It is well-known that the number of physical therapy treatment sessions varies over treatment episodes. Information is lacking, however, on the source and explanation of the variation. The purposes of the current study are: 1) to determine how the variance in the number of physical thera

  11. What factors explains the number of physical therapy treatment sessions in patients referred with low back pain: a multilevel analysis.

    NARCIS (Netherlands)

    Swinkels, I.C.S.; Wimmers, R.H.; Groenewegen, P.P.; Bosch, W.J.H. van den; Ende, C.H.M. van den

    2005-01-01

    BACKGROUND: It is well-known that the number of physical therapy treatment sessions varies over treatment episodes. Information is lacking, however, on the source and explanation of the variation. The purposes of the current study are: 1) to determine how the variance in the number of physical thera

  12. What factors explain the number of physical therapy treatment sessions in patients referred with low back pain : a multilevel analysis

    NARCIS (Netherlands)

    Swinkels, I.C.; Wimmers, R.H.; Groenewegen, P.P.; Bosch, W.J.H.M. van den; Dekker, J.; Ende, C.H.M. van den

    2005-01-01

    BACKGROUND: It is well-known that the number of physical therapy treatment sessions varies over treatment episodes. Information is lacking, however, on the source and explanation of the variation. The purposes of the current study are: 1) to determine how the variance in the number of physical thera

  13. Nondestructive Waste Assay Using Gamma-Ray Active & Passive Computed Tomography. Mixed Waste Focus Area. OST Reference Number 2123

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    1999-09-01

    This project was supported by the Mixed Waste Focus Area (MWFA) and the Federal Environmental Technology Center (FETC) to develop an improved nondestructive assay (NDA) capability that uses gamma-ray computed tomography and gamma-energy spectral analysis techniques to perform waste assay measurements. It was the intent of the Gamma-Ray Active & Passive Computed Tomography (A&PCT) development and demonstration project to enhance the overall utility of waste assay through the implementation of techniques that can accommodate known measurement complications, e.g., waste matrix and radioactive material distribution heterogeneities. This technology can measure the radionuclide content in all types of waste regardless of their classification as low level (LLW), transuranic (TRU) or mixed (MLLW or MTRU). The nondestructive waste assay capability needed to support Department of Energy (DOE) mixed waste characterization needs is necessarily a function of the waste form configurations in inventory. These waste form configurations exhibit a number of variables impacting assay system response that must be accounted for to ensure valid measurement data. Such variables include: matrix density, matrix elemental composition, matrix density distribution, radioactive material radionuclidic/isotopic composition, radioactive material physical/chemical form, and physical distribution in the waste matrix. Existing nondestructive assay technologies have identified capability limits with respect to these variables. Certain combinations of these variables result in waste configurations within the capability of one or more of the existing systems. Other combinations that are prevalent in the inventory are outside of the capability of such systems.

  14. Starting and Operating Live Virtual Reference Services: A How-To-Do-It Manual for Librarians. How-To-Do-It Manuals for Librarians, Number 118.

    Science.gov (United States)

    Meola, Marc; Stormont, Sam

    This guide discusses the essentials of live virtual reference, preparing for virtual reference, and implementing and incorporating virtual reference. Chapter 1, "Understanding Live Virtual Reference," lays out what virtual reference is and how it compares to other forms of reference. Chapter 2, "Offering Live Virtual Reference," presents ten…

  15. Evaluating the effective numbers of independent tests and significant p-value thresholds in commercial genotyping arrays and public imputation reference datasets.

    Science.gov (United States)

    Li, Miao-Xin; Yeung, Juilian M Y; Cherny, Stacey S; Sham, Pak C

    2012-05-01

    Current genome-wide association studies (GWAS) use commercial genotyping microarrays that can assay over a million single nucleotide polymorphisms (SNPs). The number of SNPs is further boosted by advanced statistical genotype-imputation algorithms and large SNP databases for reference human populations. The testing of a huge number of SNPs needs to be taken into account in the interpretation of statistical significance in such genome-wide studies, but this is complicated by the non-independence of SNPs because of linkage disequilibrium (LD). Several previous groups have proposed the use of the effective number of independent markers (M(e)) for the adjustment of multiple testing, but current methods of calculation for M(e) are limited in accuracy or computational speed. Here, we report a more robust and fast method to calculate M(e). Applying this efficient method [implemented in a free software tool named Genetic type 1 error calculator (GEC)], we systematically examined the M(e), and the corresponding p-value thresholds required to control the genome-wide type 1 error rate at 0.05, for 13 Illumina or Affymetrix genotyping arrays, as well as for HapMap Project and 1000 Genomes Project datasets which are widely used in genotype imputation as reference panels. Our results suggested the use of a p-value threshold of ~10(-7) as the criterion for genome-wide significance for early commercial genotyping arrays, but slightly more stringent p-value thresholds ~5 × 10(-8) for current or merged commercial genotyping arrays, ~10(-8) for all common SNPs in the 1000 Genomes Project dataset and ~5 × 10(-8) for the common SNPs only within genes.

  16. Precision of the reportable result. Simultaneous optimisation of number of preparations and injections for sample and reference standard in quantitative liquid chromatography.

    Science.gov (United States)

    Ermer, J; Agut, C

    2014-08-01

    In pharmaceutical analysis, the precision of the reportable result, i.e. the result which is to be compared to the specification limit, is relevant for the evaluation of the suitability of the analytical procedure. But also for other applications, the precision of the result is important and an optimisation often of interest. However, increasing the number of determinations (e.g. injections or preparations) will reduce only the variability (or standard error) of the corresponding precision level. Therefore, the knowledge of the individual variance contributions, obtained from reliable precision studies is important to determine on a scientific basis which format of the (reportable) result, i.e. the number of injections and sample preparations (or even series), should be used. In case of relative analytical procedures such as LC, the calibration model and format, i.e. the number of determinations of the reference standard is one of the factors (besides instrument, operator, reagents, etc.) affecting the between-series variance contribution at intermediate precision/reproducibility level. Consequently, the precision of the reportable result is only valid for the calibration format used to obtain intermediate precision/reproducibility. Instead of repeating the whole precision study to optimize the calibration format, the present paper describes a statistical approach using variability results from the original precision study.

  17. Study of association between ovarian volume with the number of antral follicles and third day of menstruation FSH in infertile patients referred to Omid Persian gulf infertility Clinic

    Directory of Open Access Journals (Sweden)

    Elham Rahmani

    2016-09-01

    Full Text Available Background: Ovarian reserve tests have appeared as important, useful and new tools in evaluation of infertile women and by doing these tests, we can do for infertile couples advanced and necessary measures quickly. The goal of this study was to investigate the association between ovarian volume, Antral follicle counts and serum level of FSH at the third day of menstruation. Material and Methods: This study was conducted on 78 women between 18-49 years old who referred to Omid Persian gulf infertility Clinic with complaining of infertility in 2014. In patients who had inclusion criteria, measurement of ovarian volume were done with calculation of three diameters and the number of antral follicles by using vaginal ultrasound in third day of menstruation. Also, in this patients were measured the levels of FSH&LH in third day of menstruation. Pearson correlation coefficient were used to examine the relationship between ovarian volume and the number of Antral follicles and serum levels. Results: ovarian volume and Antral follicle counts (p=0.0001 decreased and serum level of FSH (p=0.0001 and LH (p=0,022 increased significantly with increasing of age. There was a strong positive correlation between ovarian volume and Antral follicle counts (r=0.96, p=0.0001 and there was a strong reversed correlation between ovarian volume and Antral follicle counts with FSH (r=0.50, p=0.0001. Conclusion: By increasing age, ovarian volume and Antral follicle counts decreased and FSH&LH levels increased. In fact, in the initial study of infertile patients, even by diagnosis of reduction in ovarian volume and Antral follicle count should be performed advanced therapies and there is no need to wait for expensive tests result.

  18. Disabling Emotion in Young Children with Particular Reference to Depression and Suicide: An Overview of Current Research. Unit for Child Studies Selected Papers Number 12.

    Science.gov (United States)

    Phillips, Shelley

    A review of the literature and a survey of texts show a remarkable absence of concern and reference to depression and suicidal behavior in young children. The meaning of death, the depressive and suicidal consequences of the agony of aloneness, and the fear of parental hostility, rage and abandonment are elements of early and middle childhood…

  19. 30 CFR 7.409 - Approval marking.

    Science.gov (United States)

    2010-07-01

    ... approval number in addition to the number and size (gauge) of conductors and cable type. For cables containing electric conductors, the marking shall also include the voltage rating. For splices, the...

  20. Drugs Approved for Melanoma

    Science.gov (United States)

    ... Ask about Your Treatment Research Drugs Approved for Melanoma This page lists cancer drugs approved by the ... that are not listed here. Drugs Approved for Melanoma Aldesleukin Cobimetinib Cotellic (Cobimetinib) Dabrafenib Dacarbazine DTIC-Dome ( ...

  1. Trends in global approvals of biotech crops (1992-2014).

    Science.gov (United States)

    Aldemita, Rhodora R; Reaño, Ian Mari E; Solis, Renando O; Hautea, Randy A

    2015-01-01

    With the increasing number of genetically modified (GM) events, traits, and crops that are developed to benefit the global population, approval of these technologies for food, feed, cultivation and import in each country may vary depending on needs, demand and trade interest. ISAAA established a GMO Approval Database to document global approvals of biotech crops. GM event name, crops, traits, developer, year of approval for cultivation, food/feed, import, and relevant dossiers were sourced from credible government regulatory websites and biosafety clearinghouses. This paper investigates the trends in GM approvals for food, feed and cultivation based on the number of approving countries, GM crops, events, and traits in the last 23 y (1992-2014), rationale for approval, factors influencing approvals, and their implications in GM crop adoption. Results show that in 2014, there was an accumulative increase in the number of countries granting approvals at 29 (79% developing countries) for commercial cultivation and 31 (70% developing countries) for food and 19 (80% developing developing) for feed; 2012 had the highest number of approving countries and cultivation approvals; 2011 had the highest number of country approvals for feed, and 2014 for food approvals. Herbicide tolerance trait had the highest events approved, followed by insect tolerance traits. Approvals for food product quality increased in the second decade. Maize had the highest number of events approved (single and stacked traits), and stacked traits product gradually increased which is already 30% of the total trait approvals. These results may indicate understanding and acceptance of countries to enhance regulatory capability to be able to benefit from GM crop commercialization. Hence, the paper provided information on the trends on the growth of the GM crop industry in the last 23 y which may be vital in predicting future GM crops and traits.

  2. Hunan Rare Earth Group Approved

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    <正>Following Guangdong,Guangxi,Fujian and Jiangxi,Hunan announced that it would consolidate its rare earth resources-the consolidation plan of Hunan Rare Earth Group has been approved. Consolidation of the rare earth industry of south China is in full swing.According to "Several Opinions of the State Council on Promoting the Sustainable and Healthy Development of Rare Earth Industry"(hereinafter referred to as "Several Opinions")released in 2011,

  3. Biosimilars approval process.

    Science.gov (United States)

    Zuñiga, Leyre; Calvo, Begoña

    2010-04-01

    For similar biological medicinal products, the so-called biosimilars, clinical trials are required rather than just the bioequivalence studies required to support the registration of a generic small molecule drug product. The EU Directive 2001/83/EC, as amended, stated that where a biological medicinal product which is similar to a reference biological product, does not meet the conditions in the definition of generic medicinal products the results of appropriate pre-clinical tests or clinical trials relating to these conditions must be provided. The challenge is to determine the exact nature of the non-clinical and clinical programme required to gain regulatory approval. The applicant is encouraged to provide a detailed description of the strategy used to demonstrate the biosimilar and the reference product have similar profiles in terms of quality, safety and efficacy. The extent to which comparability can be proven will have quite an impact on how many non-clinical and clinical studies the biosimilar applicant will be required to conduct. The dossier submitted by the applicant to the EMEA should cover all aspects of the comparability assessment and must include data on possible unwanted immune reactions to the therapeutic protein. Post-marketing pharmacovigilance plans are also expected to be included in the biosimilar dossier.

  4. Post-Approval Studies

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CDRH Post-Approval Studies Program encompasses design, tracking, oversight, and review responsibilities for studies mandated as a condition of approval of a...

  5. Reference Revolutions.

    Science.gov (United States)

    Mason, Marilyn Gell

    1998-01-01

    Describes developments in Online Computer Library Center (OCLC) electronic reference services. Presents a background on networked cataloging and the initial implementation of reference services by OCLC. Discusses the introduction of OCLC FirstSearch service, which today offers access to over 65 databases, future developments in integrated…

  6. 75 FR 65551 - Notice of Passenger Facility Charge (PFC) Approvals and Disapprovals

    Science.gov (United States)

    2010-10-25

    ... Authority, Wichita, Kansas. Application Number: 10-07-C-00-ICT. Application Type: Impose and use a PFC. PFC... Disapprovals. In September 2010, there were four applications approved. This notice also includes information on seven applications, one approved in May 2009, two approved in July 2010, and four approved...

  7. Reference Citation Format

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    <正>The format for citations in text and for bibliographic references follows GB/T 7714—2005.The citation should be ordered in number as it appears in the text of the submitted article.For journal article Sun,Y.,Li,B.,&Qu,J.F.Design and implementation of library intelligent IM reference robot.New Technology of Library and Information Service(in Chinese),2011,205:88–92.

  8. Reference Citation Format

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>The format for citations in text and for bibliographic references follows GB/T 7714—2005.The citation should be ordered in number as it appears in the text of the submitted article.For journal article Sun,Y.,Li,B.,&Qu,J.F.Design and implementation of library intelligent IM reference robot.New Technology of Library and Information Service(in Chinese),

  9. Drugs Approved for Thyroid Cancer

    Science.gov (United States)

    ... Ask about Your Treatment Research Drugs Approved for Thyroid Cancer This page lists cancer drugs approved by the ... that are not listed here. Drugs Approved for Thyroid Cancer Cabozantinib-S-Malate Caprelsa (Vandetanib) Cometriq (Cabozantinib-S-Malate) Doxorubicin ...

  10. Drugs Approved for Lung Cancer

    Science.gov (United States)

    ... Ask about Your Treatment Research Drugs Approved for Lung Cancer This page lists cancer drugs approved by the ... listed here. Drugs Approved for Non-Small Cell Lung Cancer Abitrexate (Methotrexate) Abraxane (Paclitaxel Albumin-stabilized Nanoparticle Formulation) ...

  11. Roaming Reference: Reinvigorating Reference through Point of Need Service

    Directory of Open Access Journals (Sweden)

    Kealin M. McCabe

    2011-11-01

    Full Text Available Roaming reference service was pursued as a way to address declining reference statistics. The service was staffed by librarians armed with iPads over a period of six months during the 2010-2011 academic year. Transactional statistics were collected in relation to query type (Research, Facilitative or Technology, location and approach (librarian to patron, patron to librarian or via chat widget. Overall, roaming reference resulted in an additional 228 reference questions, 67% (n=153 of which were research related. Two iterations of the service were implemented, roaming reference as a standalone service (Fall 2010 and roaming reference integrated with traditional reference desk duties (Winter 2011. The results demonstrate that although the Weller Library’s reference transactions are declining annually, they are not disappearing. For a roaming reference service to succeed, it must be a standalone service provided in addition to traditional reference services. The integration of the two reference models (roaming reference and reference desk resulted in a 56% decline in the total number of roaming reference questions from the previous term. The simple act of roaming has the potential to reinvigorate reference services as a whole, forcing librarians outside their comfort zones, allowing them to reach patrons at their point of need.

  12. Virtual Reference Services.

    Science.gov (United States)

    Brewer, Sally

    2003-01-01

    As the need to access information increases, school librarians must create virtual libraries. Linked to reliable reference resources, the virtual library extends the physical collection and library hours and lets students learn to use Web-based resources in a protected learning environment. The growing number of virtual schools increases the need…

  13. Reference Citation Format

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>The format for citations in text and for bibliographic references follows the Publication Manual of the American Psychological Association(5thEd.,2001)and GB/T 7714-2005.The citation of printed word should be ordered in number as it appears in the text of the submitted

  14. 我国18项干化学检测项目参考区间调查及与已发布和即将发布的卫生行业标准的比较和分析%Comparison and analysis on the reference intervals of Chinese 18 dry chemistry items with current health industry standards and draft for approval

    Institute of Scientific and Technical Information of China (English)

    钟堃; 王薇; 何法霖; 王治国

    2016-01-01

    目的:对我国医院检验科干化学检验项目的参考区间进行调查和分析,并与现行和即将发布的卫生行业标准进行比较,全面了解我国医院检验科干化学检验项目的参考区间应用情况。方法采用基于Web方式的室间质量评价(EQA)软件系统收集参加2014年全国干化学和常规化学参考区间调查的实验室上报数据,利用单样本t检验等统计方法对数据进行分析。结果有83.3%(30/36)的项目参考区间上、下限与卫生行业标准存在差异(P<0.05)。有83.3%(20/24)的项目男、女性参考区间上、下限与卫生行业标准存在差异(P<0.05)。有73.6%(53/72)的项目按检测系统分组得出的参考区间上、下限与卫生行业标准存在差异(P<0.05)。结论我国干化学检验项目目前应用的参考区间与卫生行业标准存在一定的差异,建议建立中国人群干化学检验项目的参考区间。%Objective To investigate the current application status of reference intervals for dry chemistry items in China,and compare with current health industry standards and draft for approval. Methods By Web-based external quality assessment(EQA) software system,the submitted data from the laboratories, which attended national reference interval investigation for dry chemistry and routine chemistry,2014,were collected. Statistical methods,such as single-sample t determination,were used to analyze the data. Results A total of 83.3%(30/36) of reference interval upper and lower limits had differences compared with those from health industry standards (P<0.05),and 83.3%(20/24)of male and female reference interval upper and lower limits had significantly statistical differences compared with those from health industry standards(P<0.05). The 73.6%(53/72)of measurement system reference interval upper and lower limits had significantly statistical differences compared with those from health industry standards(P<0

  15. Drugs Approved for Retinoblastoma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for retinoblastoma. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  16. Drugs Approved for Neuroblastoma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for neuroblastoma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  17. FWS Approved Acquisition Boundaries

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This data layer depicts the external boundaries of lands and waters that are approved for acquisition by the U.S. Fish and Wildlife Service (USFWS) in North America,...

  18. Premarket Approvals (PMA)

    Data.gov (United States)

    U.S. Department of Health & Human Services — Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An...

  19. FWS Approved Acquisition Boundaries

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This data layer depicts the external boundaries of lands and waters that are approved for acquisition by the U.S. Fish and Wildlife Service (USFWS) in North...

  20. 10 CFR 25.8 - Information collection requirements: OMB approval.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Information collection requirements: OMB approval. 25.8 Section 25.8 Energy NUCLEAR REGULATORY COMMISSION ACCESS AUTHORIZATION General Provisions § 25.8...), 25.21(c), 25.27(b), 25.29, and 25.31, SF-86 is approved under control number 3206-0007. (3) In §...

  1. 28 CFR 48.15 - Temporary approval.

    Science.gov (United States)

    2010-07-01

    ... Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) NEWSPAPER PRESERVATION ACT § 48.15 Temporary... temporary approval may do so by delivering a statement of protest or telephoning his views to an employee of the Department of Justice, whose name, address and telephone number shall be designated by...

  2. Pembrolizumab: first global approval.

    Science.gov (United States)

    Poole, Raewyn M

    2014-10-01

    Pembrolizumab [Keytruda(®) (US)], a humanized monoclonal antibody against the programmed death receptor-1 (PD-1) protein, has been developed by Merck & Co for the treatment of cancer. Pembrolizumab has received its first global approval for the treatment of advanced, unresectable or metastatic malignant melanoma in the US, for use in patients with disease progression after prior treatment with ipilimumab and, for BRAF V600 mutation-positive patients, a BRAF inhibitor. It is the first anti-PD-1 therapy to receive regulatory approval in the US, and is currently under regulatory review in the EU. This article summarizes the milestones in the development of pembrolizumab leading to this first approval for the treatment of malignant melanoma.

  3. Pomalidomide: first global approval.

    Science.gov (United States)

    Elkinson, Shelley; McCormack, Paul L

    2013-05-01

    Pomalidomide (Pomalyst(®)) is a small molecule analogue of thalidomide under development with Celgene Corporation for the oral treatment of haematological and connective tissue diseases. Pomalidomide has been approved in the USA and is awaiting approval in the EU for use with low-dose dexamethasone for the treatment of relapsed and refractory multiple myeloma that has progressed following at least two prior therapies, including lenalidomide and bortezomib. The efficacy and safety of pomalidomide as monotherapy in patients with relapsed and refractory multiple myeloma has also been evaluated in a phase III trial. The agent is in phase III clinical development for the treatment of myelofibrosis and in phase II development for systemic sclerosis. Pomalidomide is also being investigated in patients with amyloidosis, prostate cancer, small cell lung cancer, pancreatic cancer, graft-versus-host disease, and Waldenstrom's macroglobulinaemia. This article summarizes the milestones in the development of pomalidomide leading to this first global approval for relapsed and refractory multiple myeloma.

  4. Apremilast: first global approval.

    Science.gov (United States)

    Poole, Raewyn M; Ballantyne, Anita D

    2014-05-01

    Apremilast (Otezla(®)), an oral small molecule inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4), is under development with Celgene Corporation for the treatment of psoriatic arthritis, psoriasis, ankylosing spondylitis, Behçet's syndrome, atopic dermatitis, and rheumatoid arthritis. Apremilast is indicated for the treatment of active psoriatic arthritis in adults. Apremilast has received its first global approval for this indication in the USA. Regulatory submissions for approval in this indication are under review in Canada and Europe. Regulatory filings have also been submitted for apremilast in the treatment of plaque psoriasis in the USA and Europe. This article summarizes the milestones in the development of apremilast leading to its first approval for the treatment of psoriatic arthritis.

  5. Reference Citation Format

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>The format for citations in text and for bibliographic references follows the Publication Manual of the American Psychological Association(5thEd.,2001)and GB/T 7714-2005.The citation of printed word should be ordered in number as it appears in the text of the submitted article.For journal article1 Goodrum,A.A.,McCain,K.W.,&Lawrence,S.,et al.Scholarly publishing in the Internet age:

  6. Reference Citation Format

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    <正>The format for citations in text and for bibliographic references follows the Publication Manual of the American Psychological Association(5thEd.,2001)and GB/T 7714-2005.The citation of printed word should be ordered in number as it appears in the text of the submitted article.For journal article1 Goodrum,A.A.,McCain,K.W.,&Lawrence,S.,et al.Scholarly publishing in the Internet

  7. Reference Citation Format

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    <正>The format for citations in text and for bibliographic references follows the Publication Manual of the American Psychological Association(5thEd.,2001)and GB/T 7714-2005.The citation of printed word should be ordered in number as it appears in the text of the submitted article.For journal article1 Goodrum,A.A.,McCain,K.W.,&Lawrence,S.,et al.Scholarly publishing in the Internet

  8. Reference Citation Format

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    <正>The format for citations in text and for bibliographic references follows the Publication Manual of the American Psychological Association(5thEd.,2001)and GB/T 7714-2005.The citation of printed word should be ordered in number as it appears in the text of the submitted article.For journal article1 Goodrum,A.A.,McCain,K.W.,&Lawrence,S.,et al.Scholarly publishing in the Internet age:

  9. FDA Approval for Imiquimod

    Science.gov (United States)

    On July 15, 2004, the U.S. Food and Drug Administration (FDA) announced the approval of a new indication for Aldara® (imiquimod) topical cream for the treatment of superficial basal cell carcinoma (sBCC), a type of skin cancer.

  10. Heartland Winthrop Approval

    Science.gov (United States)

    This May 19, 2016 letter from EPA approves the petition from Heartland Corn Products regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable fuel (D-code 6) RINs under the RFS program.

  11. FHR Iowa Falls Approval

    Science.gov (United States)

    This October 22, 2015, letter from EPA approves the petition from Flint Hills Resources, LLC, regarding non-grandfathered ethanol produced through the FHR Iowa Falls Process, qualifying under the Clean Air Act for renewable fuel (D-code 6) RINs under the R

  12. Number names and number understanding

    DEFF Research Database (Denmark)

    Ejersbo, Lisser Rye; Misfeldt, Morten

    2014-01-01

    through using mathematical names for the numbers such as one-ten-one for 11 and five-ten-six for 56. The project combines the renaming of numbers with supporting the teaching with the new number names. Our hypothesis is that Danish children have more difficulties learning and working with numbers, because...

  13. 33 CFR 175.21 - Condition; size and fit; approval marking.

    Science.gov (United States)

    2010-07-01

    ...; and (c) Legibly marked with its approval number, as specified in 46 CFR part 160. ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Condition; size and fit; approval...; size and fit; approval marking. No person may use a recreational boat unless each PFD required by §...

  14. Repurposing of approved cardiovascular drugs.

    Science.gov (United States)

    Ishida, Junichi; Konishi, Masaaki; Ebner, Nicole; Springer, Jochen

    2016-09-20

    Research and development of new drugs requires both long time and high costs, whereas safety and tolerability profiles make the success rate of approval very low. Drug repurposing, applying known drugs and compounds to new indications, has been noted recently as a cost-effective and time-unconsuming way in developing new drugs, because they have already been proven safe in humans. In this review, we discuss drug repurposing of approved cardiovascular drugs, such as aspirin, beta-blockers, angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, cardiac glycosides and statins. Regarding anti-tumor activities of these agents, a number of experimental studies have demonstrated promising pleiotropic properties, whereas all clinical trials have not shown expected results. In pathological conditions other than cancer, repurposing of cardiovascular drugs is also expanding. Numerous experimental studies have reported possibilities of drug repurposing in this field and some of them have been tried for new indications ('bench to bedside'), while unexpected results of clinical studies have given hints for drug repurposing and some unknown mechanisms of action have been demonstrated by experimental studies ('bedside to bench'). The future perspective of experimental and clinical studies using cardiovascular drugs are also discussed.

  15. Approval times and the safety of new pharmaceuticals.

    Science.gov (United States)

    Rudholm, Niklas

    2004-12-01

    This study examined the relationship between the approval times for new pharmaceuticals and the number of adverse drug reactions reported to the Swedish Medical Products Agency. Yearly time-series data concerning the number of adverse drug reactions, as well as data concerning prices and quantities sold for 25 pharmaceutical substances during the period 1972-1996 were used. The results show that shorter approval times are associated with more adverse drug reactions, but also that the effects are quite small.

  16. Sagan numbers

    OpenAIRE

    Mendonça, J. Ricardo G.

    2012-01-01

    We define a new class of numbers based on the first occurrence of certain patterns of zeros and ones in the expansion of irracional numbers in a given basis and call them Sagan numbers, since they were first mentioned, in a special case, by the North-american astronomer Carl E. Sagan in his science-fiction novel "Contact." Sagan numbers hold connections with a wealth of mathematical ideas. We describe some properties of the newly defined numbers and indicate directions for further amusement.

  17. Fibonacci numbers

    CERN Document Server

    Vorob'ev, Nikolai Nikolaevich

    2011-01-01

    Fibonacci numbers date back to an 800-year-old problem concerning the number of offspring born in a single year to a pair of rabbits. This book offers the solution and explores the occurrence of Fibonacci numbers in number theory, continued fractions, and geometry. A discussion of the ""golden section"" rectangle, in which the lengths of the sides can be expressed as a ration of two successive Fibonacci numbers, draws upon attempts by ancient and medieval thinkers to base aesthetic and philosophical principles on the beauty of these figures. Recreational readers as well as students and teacher

  18. Implementation of a reference-scaled average bioequivalence approach for highly variable generic drug products by the US Food and Drug Administration.

    Science.gov (United States)

    Davit, Barbara M; Chen, Mei-Ling; Conner, Dale P; Haidar, Sam H; Kim, Stephanie; Lee, Christina H; Lionberger, Robert A; Makhlouf, Fairouz T; Nwakama, Patrick E; Patel, Devvrat T; Schuirmann, Donald J; Yu, Lawrence X

    2012-12-01

    Highly variable (HV) drugs are defined as those for which within-subject variability (%CV) in bioequivalence (BE) measures is 30% or greater. Because of this high variability, studies designed to show whether generic HV drugs are bioequivalent to their corresponding HV reference drugs may need to enroll large numbers of subjects even when the products have no significant mean differences. To avoid unnecessary human testing, the US Food and Drug Administration's Office of Generic Drugs developed a reference-scaled average bioequivalence (RSABE) approach, whereby the BE acceptance limits are scaled to the variability of the reference product. For an acceptable RSABE study, an HV generic drug product must meet the scaled BE limit and a point estimate constraint. The approach has been implemented successfully. To date, the RSABE approach has supported four full approvals and one tentative approval of HV generic drug products.

  19. 近年来美国FDA批准上市药品分析%Analysis of Drugs Approved by FDA in Recent Years

    Institute of Scientific and Technical Information of China (English)

    任瑜; 杨悦

    2014-01-01

    目的:分析近年来FDA批准上市的药品,为我国药品的研发和审批提供借鉴。方法通过查阅文献,分析美国上市药品的数量变化、重点治疗领域和审评时限变化。结果与结论近年来FDA批准上市的药品数量呈增加趋势,对孤儿药、儿科药、肿瘤疾病、神经及精神疾病等治疗领域重视度增加,审评时限逐渐缩短。我国可以参考美国FDA批准上市的药品,改进药品审批政策,从而促进创新药和仿制药的发展。%Objective To analyze drugs approved by FDA in recent years, and provide references for developing and approving drugs in China. Methods This article analyzes the number, review timeline and therapeutic area of drugs approved in America by literature. Results and Conclusion The number of drugs approved by FDA has increased recently, the review timeline is shortened, and they have improved their focus on orphan drug, pediatric drug, cancer area, neurological and psychiatric disease and so on. Our country can refer to the drugs FDA has approved, and improve the policies of drugs approving to facilitate the development of new drugs and generic drugs.

  20. Number names and number understanding

    DEFF Research Database (Denmark)

    Ejersbo, Lisser Rye; Misfeldt, Morten

    2014-01-01

    through using mathematical names for the numbers such as one-ten-one for 11 and five-ten-six for 56. The project combines the renaming of numbers with supporting the teaching with the new number names. Our hypothesis is that Danish children have more difficulties learning and working with numbers, because...... the Danish number names are more complicated than in other languages. Keywords: A research project in grade 0 and 1th in a Danish school, Base-10 system, two-digit number names, semiotic, cognitive perspectives....

  1. Beyond Natural Numbers: Negative Number Representation in Parietal Cortex

    OpenAIRE

    Blair, Kristen P.; Rosenberg-Lee, Miriam; Tsang, Jessica M.; Schwartz, Daniel L.; Menon, Vinod

    2012-01-01

    Unlike natural numbers, negative numbers do not have natural physical referents. How does the brain represent such abstract mathematical concepts? Two competing hypotheses regarding representational systems for negative numbers are a rule-based model, in which symbolic rules are applied to negative numbers to translate them into positive numbers when assessing magnitudes, and an expanded magnitude model, in which negative numbers have a distinct magnitude representation. Using an event-relate...

  2. 75 FR 45007 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

    Science.gov (United States)

    2010-07-30

    ... of Renewed Approval of Information Collection(s): Verification of Authenticity of Foreign License...: Verification of Authenticity of Foreign License, Rating and Medical Certification. Form Numbers: FAA form...

  3. 78 FR 58598 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

    Science.gov (United States)

    2013-09-24

    ... of Renewed Approval of Information Collection: Verification of Authenticity of Foreign License... INFORMATION: OMB Control Number: 2120-0724. Title: Verification of Authenticity of Foreign License,...

  4. Linaclotide: first global approval.

    Science.gov (United States)

    McWilliams, Vanessa; Whiteside, Glenn; McKeage, Kate

    2012-11-12

    Linaclotide is a once-daily, orally administered, first-in-class agonist of guanylate cyclase-C that is minimally absorbed. It is being developed to treat gastrointestinal disorders by Ironwood Pharmaceuticals and its partners, Forest Laboratories (North America), Almirall (Europe) and Astellas Pharma (Asia-Pacific). Linaclotide has received its first global approval in the US for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic idiopathic constipation (CIC), and a marketing submission has been filed in the EU for IBS-C. This article summarizes the milestones in the development of linaclotide leading to this first approval for IBS-C and CIC. This profile has been extracted and modified from the Adis R&D Insight drug pipeline database. Adis R&D Insight tracks drug development worldwide through the entire development process, from discovery, through pre-clinical and clinical studies to market launch.

  5. Pitolisant: First Global Approval.

    Science.gov (United States)

    Syed, Yahiya Y

    2016-09-01

    Pitolisant (Wakix™) is an inverse agonist of the histamine H3 receptor that is being developed by Bioproject. Oral pitolisant is approved in the EU for the treatment of narcolepsy with or without cataplexy in adults. Pitolisant has received a Temporary Authorization of Use in France for this indication in case of treatment failure, intolerance or contraindication to currently available treatment. Pitolisant has orphan drug designation in the EU and the USA. In the pivotal HARMONY I trial, pitolisant significantly decreased excessive daytime sleepiness versus placebo in adults with narcolepsy with or without cataplexy (primary endpoint). Pitolisant also significantly decreased cataplexy rate versus placebo in these patients. This article summarizes the milestones in the development of pitolisant leading to this first approval for narcolepsy.

  6. Eulerian numbers

    CERN Document Server

    Petersen, T Kyle

    2015-01-01

    This text presents the Eulerian numbers in the context of modern enumerative, algebraic, and geometric combinatorics. The book first studies Eulerian numbers from a purely combinatorial point of view, then embarks on a tour of how these numbers arise in the study of hyperplane arrangements, polytopes, and simplicial complexes. Some topics include a thorough discussion of gamma-nonnegativity and real-rootedness for Eulerian polynomials, as well as the weak order and the shard intersection order of the symmetric group. The book also includes a parallel story of Catalan combinatorics, wherein the Eulerian numbers are replaced with Narayana numbers. Again there is a progression from combinatorics to geometry, including discussion of the associahedron and the lattice of noncrossing partitions. The final chapters discuss how both the Eulerian and Narayana numbers have analogues in any finite Coxeter group, with many of the same enumerative and geometric properties. There are four supplemental chapters throughout, ...

  7. Library Reference Services.

    Science.gov (United States)

    Miller, Constance; And Others

    1985-01-01

    Seven articles on library reference services highlight reference obsolescence in academic libraries, major studies of unobtrusive reference tests, methods for evaluating reference desk performance, reference interview evaluation, problems of reference desk control, online searching by end users, and reference collection development in…

  8. Baricitinib: First Global Approval.

    Science.gov (United States)

    Markham, Anthony

    2017-03-13

    Baricitinib (Olumiant™) is an orally-administered, small-molecule, janus-associated kinase (JAK) inhibitor developed by Eli Lilly and Incyte Corporation for the treatment of rheumatoid arthritis (RA), atopic dermatitis and systemic lupus erythematosus. JAKs transduce intracellular signals from cell surface receptors for various cytokines and growth factors involved in inflammation and immune function, suggesting JAK inhibitors may be of therapeutic benefit in inflammatory conditions. In February 2017, baricitinib was approved in the EU, as monotherapy or in combination with methotrexate, for the treatment of moderate to severe active rheumatoid arthritis in adult patients who have responded inadequately to, or who are intolerant to one or more disease-modifying anti-rheumatic drugs (DMARDs). Regulatory approval to market baricitinib as a treatment for RA has also been sought in the USA and Japan. This article summarizes the milestones in the development of baricitinib leading to this first global approval for the treatment for moderate to severe active RA in adult patients who have responded inadequately to, or are intolerant to one or more DMARDs.

  9. Evolocumab: First Global Approval.

    Science.gov (United States)

    Markham, Anthony

    2015-09-01

    Evolocumab (Repatha™) is a fully human monoclonal antibody developed by Amgen that has been approved as a treatment for hypercholesterolaemia in the EU, and is awaiting approval in the USA and Japan. It specifically binds proprotein convertase subtilisin/kexin type 9 (PCSK9)-a negative regulator of low-density lipoprotein (LDL)-receptors-thereby improving the ability of the liver to bind LDL-cholesterol (LDL-C), leading to reduced LDL-C blood levels. The drug reduces LDL-C levels in patients with hypercholesterolaemia when used as monotherapy or in conjunction with a statin. This article summarizes the milestones in the development of evolocumab leading to this approval for the treatment of adults with primary hypercholesterolaemia (heterozygous familial and non-familial) or mixed dyslipidaemia as an adjunct to diet with or without a statin and/or other lipid lowering therapies, and in adults and adolescents aged ≥12 years with homozygous familial hypercholesterolaemia in combination with other lipid lowering therapies.

  10. A cross-sectional study of the number and frequency of terms used to refer to knowledge translation in a body of health literature in 2006: a Tower of Babel?

    Directory of Open Access Journals (Sweden)

    Dobbins Maureen

    2010-02-01

    Full Text Available Background The study of implementing research findings into practice is rapidly growing and has acquired many competing names (e.g., dissemination, uptake, utilization, translation and contributing disciplines. The use of multiple terms across disciplines pose barriers to communication and progress for applying research findings. We sought to establish an inventory of terms describing this field and how often authors use them in a collection of health literature published in 2006. Methods We refer to this field as knowledge translation (KT. Terms describing aspects of KT and their definitions were collected from literature, the internet, reports, textbooks, and contact with experts. We compiled a database of KT and other articles by reading 12 healthcare journals representing multiple disciplines. All articles published in these journals in 2006 were categorized as being KT or not. The KT articles (all KT were further categorized, if possible, for whether they described KT projects or implementations (KT application articles, or presented the theoretical basis, models, tools, methods, or techniques of KT (KT theory articles. Accuracy was checked using duplicate reading. Custom designed software determined how often KT terms were used in the titles and abstracts of articles categorized as being KT. Results A total of 2,603 articles were assessed, and 581 were identified as KT articles. Of these, 201 described KT applications, and 153 included KT theory. Of the 100 KT terms collected, 46 were used by the authors in the titles or abstracts of articles categorized as being KT. For all 581 KT articles, eight terms or term variations used by authors were highly discriminating for separating KT and non-KT articles (p Conclusions We collected 100 terms describing KT research. Authors used 46 of them in titles and abstracts of KT articles. Of these, approximately half discriminated between KT and non-KT articles. Thus, the need for consolidation and

  11. 46 CFR 193.01-3 - Incorporation by reference.

    Science.gov (United States)

    2010-10-01

    ... PROTECTION EQUIPMENT Application § 193.01-3 Incorporation by reference. (a) Certain material is incorporated... Specification for International Shore Connections for Marine Fire Applications, incorporation by reference approved for § 193.10-10. (2) (c) National Fire Protection Association (NFPA), 1 Batterymarch Park,...

  12. 20 CFR 416.1720 - Whom we refer.

    Science.gov (United States)

    2010-04-01

    ... Treatment of Alcoholism Or Drug Addiction § 416.1720 Whom we refer. We will refer you to an approved facility for treatment of your alcoholism or drug addiction if— (a) You are disabled; (b) You are not blind; (c) You are not 65 years old or older; and (d) Alcoholism or drug addiction is a contributing...

  13. 10 CFR 431.443 - Materials incorporated by reference.

    Science.gov (United States)

    2010-01-01

    ... reference. (a) General. The Department incorporates by reference the following standards into Subpart X of... Test Methods for Single- and Three-Phase Small Motors, IBR approved for § 431.444. (2) (c) IEEE...-1331, 1-800-678-IEEE (4333), or go to http://www.ieee.org/web/publications/home/index.html. (1)...

  14. Number theory

    CERN Document Server

    Andrews, George E

    1994-01-01

    Although mathematics majors are usually conversant with number theory by the time they have completed a course in abstract algebra, other undergraduates, especially those in education and the liberal arts, often need a more basic introduction to the topic.In this book the author solves the problem of maintaining the interest of students at both levels by offering a combinatorial approach to elementary number theory. In studying number theory from such a perspective, mathematics majors are spared repetition and provided with new insights, while other students benefit from the consequent simpl

  15. Magic Numbers

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    THE last digit of my home phone number in Beijing is 4. “So what?” European readers might ask.This was my attitude when I first lived in China; I couldn't understand why Chinese friends were so shocked at my indifference to the number 4. But China brings new discoveries every day, and I have since seen the light. I know now that Chinese people have their own ways of preserving their well being, and that they see avoiding the number 4 as a good way to stay safe.

  16. Instrumentation reference book

    CERN Document Server

    Boyes, Walt

    2002-01-01

    Instrumentation is not a clearly defined subject, having a 'fuzzy' boundary with a number of other disciplines. Often categorized as either 'techniques' or 'applications' this book addresses the various applications that may be needed with reference to the practical techniques that are available for the instrumentation or measurement of a specific physical quantity or quality. This makes it of direct interest to anyone working in the process, control and instrumentation fields where these measurements are essential.* Comprehensive and authoritative collection of technical information* Writte

  17. Reference Citation Format

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    <正>The format for citations in text and for bibliographic references follows the Publication Manual of the American Psychological Association(5thEd.,2001)and GB/T 7714-2005.The citation of printed word should be ordered in number as it appears in the text of the submitted article.For journal article1 Goodrum,A.A.,McCain,K.W.,&Lawrence,S.,et al.Scholarly publishing in the Internet age:A citation analysis of computer science literature.Information Processing and Manage-

  18. Reference Citation Format

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    <正>The format for citations in text and for bibliographic references follows the Publication Manual of the American Psychological Association(5thEd.,2001)and GB/T 7714-2005.The citation of printed word should be ordered in number as it appears in the text of the submitted article.For journal article1 Goodrum,A.A.,McCain,K.W.,&Lawrence,S.,et al.Scholarly publishing in the Internet age:A citation analysis of computer science literature.Information Processing and Management,2001,37:661-675.2 Fernandez,M.,Kadiyska,Y.,&Suciu,D.,et al.SilkRoute:A framework for publishing

  19. Reference Citation Format

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>The format for citations in text and for bibliographic references follows the Publication Manual of the American Psychological Association(5th Ed.,2001)and GB/T 7714-2005.The citation of printed word should be ordered in number as it appears in the text of the submitted article.For journal article1 Goodrum,A.A.,McCain,K.W.,&Lawrence,S.,et al.Scholarly publishing in the Internet age:A citation analysis of computer science literature.Information Processing and Management,2001,37:661-675.

  20. Reference Citation Format

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    <正>The format for citations in text and for bibliographic references follows the Publication Manual of the American Psychological Association(5thEd.,2001)and GB/T 7714-2005.The citation of printed word should be ordered in number as it appears in the text of the submitted article.For journal article1 Goodrum,A.A.,McCain,K.W.,&Lawrence,S.,et al.Scholarly publishing in the Internet age:A citation analysis of computer science literature.Information Processing and Management,2001,37:661-675.2 Fernandez.M

  1. Nice numbers

    CERN Document Server

    Barnes, John

    2016-01-01

    In this intriguing book, John Barnes takes us on a journey through aspects of numbers much as he took us on a geometrical journey in Gems of Geometry. Similarly originating from a series of lectures for adult students at Reading and Oxford University, this book touches a variety of amusing and fascinating topics regarding numbers and their uses both ancient and modern. The author intrigues and challenges his audience with both fundamental number topics such as prime numbers and cryptography, and themes of daily needs and pleasures such as counting one's assets, keeping track of time, and enjoying music. Puzzles and exercises at the end of each lecture offer additional inspiration, and numerous illustrations accompany the reader. Furthermore, a number of appendices provides in-depth insights into diverse topics such as Pascal’s triangle, the Rubik cube, Mersenne’s curious keyboards, and many others. A theme running through is the thought of what is our favourite number. Written in an engaging and witty sty...

  2. 78 FR 66826 - Prior Label Approval System: Generic Label Approval

    Science.gov (United States)

    2013-11-07

    ... submitted for evaluation and approval before use under the final rule are: (1) Labels for chicken produced..., such as ``no antibiotics administered'' or ``vegetarian fed''; (4) instructional or...

  3. 78 FR 2878 - Approval and Promulgation of Implementation Plans; Georgia: New Source Review-Prevention of...

    Science.gov (United States)

    2013-01-14

    ... Environmental protection, Air pollution control, Greenhouse gases, Incorporation by reference, Intergovernmental..., Regulatory Development Section, Air Planning Branch, Air, Pesticides and Toxics Management Division, U.S... Deterioration'' to approve changes to Georgia's SIP-approved regulations entitled ``Air Quality Control Rule...

  4. 78 FR 2415 - Agency Information Collection Activities: Application for Family Unity Benefits, Form Number I...

    Science.gov (United States)

    2013-01-11

    ... for Family Unity Benefits, Form Number I-817; Revision of a Currently Approved Collection ACTION: 30... approved information. (2) Title of the Form/Collection: Application for Family Unity Benefits. (3)...

  5. Obinutuzumab: first global approval.

    Science.gov (United States)

    Cameron, Fiona; McCormack, Paul L

    2014-01-01

    Obinutuzumab (Gazyva™) is an intravenously administered, humanized and glycoengineered, type II anti-CD20 monoclonal antibody for the treatment of B-cell malignancies. It is approved in the US for use in combination with chlorambucil for the first-line treatment of chronic lymphocytic leukaemia (CLL), and has been filed for approval in the EU in this indication. The antibody is based on GlycArt Biotechnology's (later Roche Glycart AG) proprietary GlycoMAb® technology, which uses glycoengineered antibodies that specifically increase antibody-dependent cellular cytotoxicity and thereby increase immune-mediated target cell death. Obinutuzumab is a type II anti-CD20 antibody that induces enhanced direct cell death. The monoclonal antibody is in worldwide phase III development with Roche and its subsidiaries, Genentech and Chugai Pharmaceutical, as well as Biogen Idec, for diffuse large B-cell lymphoma and non-Hodgkin's lymphoma generally, and is also in phase III development in countries outside of the US and EU for CLL.

  6. Safinamide: first global approval.

    Science.gov (United States)

    Deeks, Emma D

    2015-04-01

    Safinamide (Xadago(®)) is an oral α-aminoamide derivative developed by Newron for the treatment of Parkinson's disease (PD). The drug has both dopaminergic properties (highly selective and reversible inhibition of monoamine oxidase-B) and non-dopaminergic properties (selective sodium channel blockade and calcium channel modulation, with consequent inhibition of excessive glutamate release). Safinamide is approved in the EU, Iceland, Lichtenstein and Norway, as an add-on therapy to stable-dose levodopa, alone or in combination with other PD therapies in mid- to late-stage fluctuating PD patients; regulatory submissions have also been filed in the USA and Switzerland for its use in this indication. Additional submissions have been made in the USA, Iceland, Lichtenstein, Norway and Switzerland for early-stage PD. Safinamide has also undergone phase II investigation in PD patients with drug-induced dyskinesia (France, Germany, Austria, Canada and South Africa) or cognitive impairment (USA and Spain). This article summarizes the milestones in the development of safinamide leading to its first approval for PD.

  7. Drugs Approved for Cervical Cancer

    Science.gov (United States)

    ... Human Papillomavirus (HPV) Nonavalent Vaccine Recombinant Human Papillomavirus (HPV) Quadrivalent Vaccine Drugs Approved to Treat Cervical Cancer Avastin (Bevacizumab) Bevacizumab Blenoxane (Bleomycin) Bleomycin Hycamtin (Topotecan ...

  8. Negative Numbers

    Science.gov (United States)

    Galbraith, Mary J.

    1974-01-01

    Examination of models for representing integers demonstrates that formal operational thought is required for establishing the operations on integers. Advocated is the use of many models for introducing negative numbers but, apart from addition, it is recommended that operations on integers be delayed until the formal operations stage. (JP)

  9. Numbers, Please!

    Science.gov (United States)

    Thelin, John R.

    2013-01-01

    What topic would you choose if you had the luxury of writing forever? In this article, John Thelin provides his response: He would opt to write about the history of higher education in a way that relies on quantitative data. "Numbers, please!" is his research request in taking on a longitudinal study of colleges and universities over…

  10. FDA-Approved HIV Medicines

    Science.gov (United States)

    HIV Treatment FDA-Approved HIV Medicines (Last updated 2/27/2017; last reviewed 2/27/2017) Treatment with HIV medicines is ... approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in the ...

  11. Virtual reference services

    OpenAIRE

    Márdero Arellano, Miguel Ángel

    2001-01-01

    Analysis of virtual reference services, their standandars and new technologies that have changed the tradicional practice at the library’s reference desk. Major American virtual reference services initiatives and their characteristics are described.

  12. Electronic Approval of Invoices (AEF)

    CERN Multimedia

    2004-01-01

    With a view to the simplification of administrative procedures, AS and FI Departments have completed the second phase of the new procedure for the electronic approval of invoices via the EDH application. The aim of this new procedure is to rationalise the invoice approval process, notably by eliminating paper copies from the approval circuit. This will simplify the processing of invoices and facilitate their timely settlement, while at the same time maintaining a high level of security. Phase II includes handling the electronic approval process of invoices whose amounts do not correspond exactly to those of the associated orders. In such cases, budgetary approval is required for the entire invoiced amount. Further information can be obtained at : http://ais.cern.ch/projs/AEF/help/F_help.htm Phase II of the procedure will be introduced gradually with effect from April 2004. Finance Department, Accounts Payable Section Tel: 72295 Organisation and Procedures Tel: 75885 Information Technologies Department,...

  13. Distribution theory of algebraic numbers

    CERN Document Server

    Yang, Chung-Chun

    2008-01-01

    The book timely surveys new research results and related developments in Diophantine approximation, a division of number theory which deals with the approximation of real numbers by rational numbers. The book is appended with a list of challenging open problems and a comprehensive list of references. From the contents: Field extensions Algebraic numbers Algebraic geometry Height functions The abc-conjecture Roth''s theorem Subspace theorems Vojta''s conjectures L-functions.

  14. The theory of algebraic numbers

    CERN Document Server

    Pollard, Harry

    1998-01-01

    An excellent introduction to the basics of algebraic number theory, this concise, well-written volume examines Gaussian primes; polynomials over a field; algebraic number fields; and algebraic integers and integral bases. After establishing a firm introductory foundation, the text explores the uses of arithmetic in algebraic number fields; the fundamental theorem of ideal theory and its consequences; ideal classes and class numbers; and the Fermat conjecture. 1975 edition. References. List of Symbols. Index.

  15. Standard Reference Tables -

    Data.gov (United States)

    Department of Transportation — The Standard Reference Tables (SRT) provide consistent reference data for the various applications that support Flight Standards Service (AFS) business processes and...

  16. 42 CFR 84.50 - Types of respirators to be approved; scope of approval.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Types of respirators to be approved; scope of... Classification of Approved Respirators; Scope of Approval; Atmospheric Hazards; Service Time § 84.50 Types of respirators to be approved; scope of approval. Approvals shall be issued for the types of respirators...

  17. Drugs Approved for Stomach (Gastric) Cancer

    Science.gov (United States)

    ... about Your Treatment Research Drugs Approved for Stomach (Gastric) Cancer This page lists cancer drugs approved by the ... are not listed here. Drugs Approved for Stomach (Gastric) Cancer Cyramza (Ramucirumab) Docetaxel Doxorubicin Hydrochloride 5-FU (Fluorouracil ...

  18. Reference Citation Format

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    <正>The format for citations in text and for bibliographic references follows the Publication Manual of the American Psychological Association(5thEd.,2001)and GB/T 7714-2005.The citation of printed word should be ordered in number as it appears in the text of the submitted article.For journal article1 Goodrum,A.A.,McCain,K.W.,&Lawrence,S.,et al.Scholarly publishing in the Internet age:A citation analysis of computer science literature.Information Processing and Management,2001,37:661-675.2 Fernandez,M.,Kadiyska,Y.,&Suciu,D.,et al.SilkRoute:A framework for publishing relational data in XML.ACM Transactions on Database Systems,2002,27(4):438-493.

  19. Reference Citation Format

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    <正>The format for citations in text and for bibliographic references follows the Publication Manual of the American Psychological Association(5thEd.,2001)and GB/T 7714-2005.The citation of printed word should be ordered in number as it appears in the text of the submitted article.For journal article1 Goodrum,A.A.,McCain,K.W.,&Lawrence,S.,et al.Scholarly publishing in the Internet age:A citation analysis of computer science literature.Information Processing and Management,2001,37:661-675.2 Fernandez,M.,Kadiyska,Y.,&Suciu,D.,et al.SilkRoute:A framework for publishing relational data in XML.ACM Transactions on Database Systems,2002,27(4):438-493.

  20. Reference Citation Format

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    <正>The format for citations in text and for bibliographic references follows the Publication Manual of the American Psychological Association(5thEd.,2001)and GB/T 7714-2005.The citation of printed word should be ordered in number as it appears in the text of the submitted article.For journal article1 Goodrum,A.A.,McCain,K.W.,&Lawrence,S.,et al.Scholarly publishing in the Internet age:A citation analysis of computer science literature.Information Processing and Management,2001,37:661-675.2 Fernandez,M.,Kadiyska,Y.,&Suciu,D.,et al.SilkRoute:A framework for publishing relational data in XML.ACM Transactions on Database Systems,2002,27(4):438-493.

  1. Beyond natural numbers: negative number representation in parietal cortex.

    Science.gov (United States)

    Blair, Kristen P; Rosenberg-Lee, Miriam; Tsang, Jessica M; Schwartz, Daniel L; Menon, Vinod

    2012-01-01

    Unlike natural numbers, negative numbers do not have natural physical referents. How does the brain represent such abstract mathematical concepts? Two competing hypotheses regarding representational systems for negative numbers are a rule-based model, in which symbolic rules are applied to negative numbers to translate them into positive numbers when assessing magnitudes, and an expanded magnitude model, in which negative numbers have a distinct magnitude representation. Using an event-related functional magnetic resonance imaging design, we examined brain responses in 22 adults while they performed magnitude comparisons of negative and positive numbers that were quantitatively near (difference 6). Reaction times (RTs) for negative numbers were slower than positive numbers, and both showed a distance effect whereby near pairs took longer to compare. A network of parietal, frontal, and occipital regions were differentially engaged by negative numbers. Specifically, compared to positive numbers, negative number processing resulted in greater activation bilaterally in intraparietal sulcus (IPS), middle frontal gyrus, and inferior lateral occipital cortex. Representational similarity analysis revealed that neural responses in the IPS were more differentiated among positive numbers than among negative numbers, and greater differentiation among negative numbers was associated with faster RTs. Our findings indicate that despite negative numbers engaging the IPS more strongly, the underlying neural representation are less distinct than that of positive numbers. We discuss our findings in the context of the two theoretical models of negative number processing and demonstrate how multivariate approaches can provide novel insights into abstract number representation.

  2. Approval plans issues and innovations

    CERN Document Server

    Katz, Linda S

    2013-01-01

    How can you, as an acquisition librarians, keep current on the output of hundreds of publishers? The answer, of course, is that you cannot. For over 30 years, approval plans have been used by librarians to acquire current titles, save staff time, and build core collections. Even today, these reasons seem appropriate, as libraries try to maintain up-to-date collections and control personnel and operating budgets. However, as shown in Approval Plans: Issues and Innovations, the use of approval plans is not so simple and straightforward; their use is subject to complex procedures and policies--an

  3. Comparison and Analysis of the Reference Intervals of 9 Serum Routine Chemical Analytes between the Current Application of Clinical Laboratories and the Latest Health Industrial Standards Draft for Approval%国内临床化学9项常规项目参考区间与即将发布的卫生行业标准的比较和分析

    Institute of Scientific and Technical Information of China (English)

    钟堃; 王薇; 何法霖; 王治国

    2015-01-01

    目的:对全国医院检验科常规化学检验项目的参考区间进行调查,并与即将发布的卫生行业标准进行比较。方法采用基于 Web 方式的室间质量评价(EQA)软件系统,收集2012年度参加全国常规化学参考区间调查的实验室所上报的数据,使用专业统计软件对数据进行统计分析。结果共385家实验室回报了调查结果。在即将发布的卫生行业标准所涉及的检验项目中,绝大多数项目不分组或未给出分组时所使用的参考区间与行业标准相比较都存在显著统计学差异[t=-55.435~17.070,P <0.05,占86.1%(31/36)]。只有较少的实验室对参考区间进行了分组(约20%),部分实验室的分组规则与行业标准有一定的差异,与行业标准分组相同的实验室所给出的参考区间与行业标准相比也多存在极显著统计学差异[t=-39.365~13.155,P <0.01,占62.5%(10/16)]。结论即将发布参考区间与实际工作中所应用的参考区间差异较大,推广已经建立的具有权威性的临床常用生化检验项目参考区间很有必要在实际工作中使用行业标准所给出的参考区间前应进行参考区间的评估和验证。%Objective To investigate the current application status of reference intervals in routine chemistry and compare with the current health industry standards draft for approval.Methods By using web-based external quality assessment (EQA)software system,collected the submitted data from the laboratories which attended national reference intervals inves-tigation,used professional statistical software to analyze the data.Results 385 laboratories had submitted the investigation results.The vast majority of the analytes of attended laboratories had significant statistical differences in comparison with the health industry standards draft for approval in no grouping and not filled groups[t = - 55.435 ~ 17.070,P < 0.05, 86

  4. Reference change values.

    Science.gov (United States)

    Fraser, Callum G

    2011-09-30

    Reference change values (RCV) provide objective tools for assessment of the significance of differences in serial results from an individual. The concept is simple and the calculation easy, since all laboratories know their analytical imprecision (CV(A)) and estimates of within-subject biological variation (CV(I)) are available for a large number of quantities. Generally, CV(I) are constant over time, geography, methodology and in health and chronic stable disease. The formula is RCV=2(1/2) · Z · (CV(A)(2) + CV(I)(2))(1/2), where Z is the number of standard deviations appropriate to the probability. Correct interpretation of the semantics describing the clinical use of RCV is vital for selection of the Z-score. Many quantities of clinically importance exist for which good estimates of RCV are unavailable. Derivation of CV(I) may be difficult for such quantities: flair and imagination are required in selecting populations with chronic but stable disease on whom CV(I) can be determined. RCV can be used for delta-checking and auto-verification and laboratory information management systems (LIMS) can be adapted to do this. Recently, log-normal transformation to obtain unidirectional RCV has been used. Gaps in knowledge of RCV still require filling since the need for measures of change is clearly expressed in guidelines.

  5. A Needs Assessment of Marriage and Family Therapy Approved Supervision in Utah

    OpenAIRE

    2005-01-01

    This research presents data gathered through a needs assessment regarding approved supervision in Utah. A sample of ISO therapists in Utah gave descriptive facts about the current need for supervision in Utah as well as the number of therapists that are willing to provide supervision. Additionally, therapists that are not currently approved supervisors indicated whether or not they would be willing to become approved supervisors, what would make the designation more appealing, and what would ...

  6. Drugs Approved for Liver Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for liver cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  7. Drugs Approved for Vulvar Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for vulvar cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  8. Drugs Approved for Esophageal Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for esophageal cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  9. Drugs Approved for Vaginal Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) to prevent vaginal cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  10. Drugs Approved for Endometrial Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for endometrial cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  11. Drugs Approved for Penile Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for penile cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  12. Is It Really FDA Approved?

    Science.gov (United States)

    ... does not approve cosmetics. Examples of cosmetics are perfumes, makeup, moisturizers, shampoos, hair dyes, face and body ... and provide the agency with a notification before marketing a new formula. FDA conducts yearly inspections of ...

  13. Electronic Voucher Approval - Financial Management

    Data.gov (United States)

    US Agency for International Development — This process provides a workflow and eSignature capability which allows the CFO to router vouchers for review and electronic signature approval to COTRs in AIDW. It...

  14. Drugs Approved for Bladder Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for bladder cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

  15. Drugs Approved for Skin Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for skin cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  16. Drugs Approved for Breast Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for breast cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

  17. Drugs Approved for Kaposi Sarcoma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for Kaposi sarcoma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  18. Drugs Approved for Pancreatic Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for pancreatic cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

  19. Drugs Approved for Bone Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for bone cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  20. Elosulfase alfa: first global approval.

    Science.gov (United States)

    Sanford, Mark; Lo, Jin Han

    2014-04-01

    Elosulfase alfa (Vimizim™) is a recombinant form of N-acetylgalactosamine-6-sulfatase (GALNS) that was developed by BioMarin Pharmaceutical Inc. as an enzyme replacement therapy for patients with mucopolysaccharidosis type IVA (MPS IVA), also known as Morquio A syndrome. Patients with MPS IVA have a GALNS deficiency, which results in serious musculoskeletal, cardiorespiratory and other system disturbances. Elosulfase alfa was approved by the US FDA on 14 February 2014 for the treatment of MPS IVA. The European Medicines Agency Committee for Medicinal Products for Human Use (CHMP) has recently recommended that elosulfase alfa be approved for use in the EU in the same indication. Within the last year, the manufacturer has also filed applications for approval for the use of elosulfase alfa in MPS IVA in Brazil, Australia, Canada and Mexico. This article summarizes the milestones in the development of elosulfase alfa leading to its first global approval in MPS IVA.

  1. Drugs Approved for Prostate Cancer

    Science.gov (United States)

    ... 2015 2014 2013 2012 Media Resources Media Contacts Multicultural ... This page lists cancer drugs approved by the Food and Drug Administration (FDA) for prostate cancer. The list includes generic ...

  2. Trulance Approved for Chronic Constipation

    Science.gov (United States)

    ... news/fullstory_163171.html Trulance Approved for Chronic Constipation Drug designed to stimulate upper gastrointestinal tract To ... U.S. Food and Drug Administration to treat persistent constipation of unknown (idiopathic) cause in adults. Some 42 ...

  3. 2002 reference document; Document de reference 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    This 2002 reference document of the group Areva, provides information on the society. Organized in seven chapters, it presents the persons responsible for the reference document and for auditing the financial statements, information pertaining to the transaction, general information on the company and share capital, information on company operation, changes and future prospects, assets, financial position, financial performance, information on company management and executive board and supervisory board, recent developments and future prospects. (A.L.B.)

  4. 32 CFR 732.26 - Standard document numbers.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Standard document numbers. 732.26 Section 732.26... Document Numbers § 732.26 Standard document numbers. Adjudication authorities will assign to each claim approved for payment, a unique 15 position alpha/numeric standard document number (SDN)....

  5. Adapting drug approval pathways for bacteriophage-based therapeutics

    Directory of Open Access Journals (Sweden)

    Callum Cooper

    2016-08-01

    Full Text Available The global rise of multi-drug resistant bacteria has resulted in the notion that an antibiotic apocalypse is fast approaching. This has led to a number of well publicized calls for global funding initiatives to develop new antibacterial agents. The long clinical history of phage therapy in Eastern Europe, combined with more recent in vitro and in vivo success, demonstrates the potential for whole phage or phage based antibacterial agents. To date, no whole phage or phage derived products are approved for human therapeutic use in the EU or USA. There are at least three reasons for this: (i phages possess different biological, physical and pharmacological properties compared to conventional antibiotics. Phages need to replicate in order to achieve a viable antibacterial effect, resulting in complex pharmacodynamics / pharmacokinetics. (ii The specificity of individual phages requires multiple phages to treat single species infections, often as part of complex cocktails. (iii The current approval process for antibacterial agents has evolved with the development of chemically based drugs at its core, and is not suitable for phages. Due to similarities with conventional antibiotics, phage derived products such as endolysins are suitable for approval under current processes as biological therapeutic proteins. These criteria render the approval of phages for clinical use theoretically possible but not economically viable. In this review, pitfalls of the current approval process will be discussed for whole phage and phage derived products, in addition to the utilization of alternative approval pathways including adaptive licensing and Right to try legislation.

  6. 9 CFR 147.52 - Approved tests.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Approved tests. 147.52 Section 147.52... Approved Tests § 147.52 Approved tests. (a) The procedures for the bacteriological examination of poultry and poultry environments described in this part are approved tests for use in the NPIP. In...

  7. Cognitive representation of negative numbers.

    Science.gov (United States)

    Fischer, Martin H

    2003-05-01

    To understand negative numbers, must we refer to positive number representations (the phylogenetic hypothesis), or do we acquire a negative mental number line (the ontogenetic hypothesis)? In the experiment reported here, participants made lateralized button responses to indicate the larger of two digits from the range -9 to 9. Digit pairs were displayed spatially congruent or incongruent with either a phylogenetic or an ontogenetic mental number line. The pattern of decision latencies suggests that negative numbers become associated with left space, thus supporting the ontogenetic view.

  8. Comprehensive NASA Cis-Lunar Earth Moon Libration Orbit Reference and Web Application Project

    Data.gov (United States)

    National Aeronautics and Space Administration — To finalize a comprehensive NASA Cis-Lunar / Earth-Moon Libration Orbit Reference and Web Application begun using FY13 IRAD funding approved in May 2013. This GSFC...

  9. Genetics Home Reference

    Science.gov (United States)

    Skip Navigation Bar Home Current Issue Past Issues Genetics Home Reference Past Issues / Spring 2007 Table of ... of this page please turn Javascript on. The Genetics Home Reference (GHR) Web site — ghr.nlm.nih. ...

  10. CMS Statistics Reference Booklet

    Data.gov (United States)

    U.S. Department of Health & Human Services — The annual CMS Statistics reference booklet provides a quick reference for summary information about health expenditures and the Medicare and Medicaid health...

  11. Best Reference Sources 2001.

    Science.gov (United States)

    Coutts, Brian; McConnell, Tamara

    2002-01-01

    Presents an annotated list of the best reference materials published in 2001. Discusses activity in the reference publishing industry; costs; and lists print materials, Web sites, databases, and CD-ROMs. (LRW)

  12. Cohomology of number fields

    CERN Document Server

    Neukirch, Jürgen; Wingberg, Kay

    2013-01-01

    The second edition is a corrected and extended version of the first. It is a textbook for students, as well as a reference book for the working mathematician, on cohomological topics in number theory. The first part provides algebraic background: cohomology of profinite groups, duality groups, free products, and homotopy theory of modules, with new sections on spectral sequences and on Tate cohomology of profinite groups. The second part deals with Galois groups of local and global fields: Tate duality, structure of absolute Galois groups of local fields, extensions with restricted ramificatio

  13. Herbal reference standards.

    Science.gov (United States)

    Schwarz, Michael; Klier, Bernhard; Sievers, Hartwig

    2009-06-01

    This review describes the current definitions and regulatory requirements that apply to reference standards that are used to analyse herbal products. It also describes and discusses the current use of reference substances and reference extracts in the European and United States pharmacopoeias.

  14. 78 FR 76383 - Notice of Passenger Facility Charge (PFC) Approvals and Disapprovals

    Science.gov (United States)

    2013-12-17

    ... Airport Authority, Mobile, Alabama. Application Number: 13-06-C-00-MOB. Application Type: Impose and use a... Regional Airport (MOB). Determination: Approved. Based on information submitted in the public agency's... annual enplanements at MOB. Brief Description of Projects Approved for Collection and Use:...

  15. 76 FR 77550 - Extension of Approved Information Collection; OMB Control No. 1004-0162

    Science.gov (United States)

    2011-12-13

    ... Management and Budget (OMB) extend an existing approval to collect information from entities which conduct... Number: 1004-0162. Abstract: The BLM and FS collect this information in order to ensure that geophysical... Bureau of Land Management Extension of Approved Information Collection; OMB Control No. 1004-0162...

  16. 76 FR 68757 - Information Collection Approved by the Office of Management and Budget

    Science.gov (United States)

    2011-11-07

    ... COMMISSION Information Collection Approved by the Office of Management and Budget AGENCY: Federal... Office of Management and Budget (OMB) approval for the following public information collections pursuant... collection of information unless it displays a currently valid OMB control number, and no person is...

  17. 76 FR 40908 - Information Collection Approved by the Office of Management and Budget

    Science.gov (United States)

    2011-07-12

    ... COMMISSION Information Collection Approved by the Office of Management and Budget AGENCY: Federal... Management and Budget (OMB) approval for the following public information collection(s) pursuant to the... information unless it displays a currently valid OMB control number, and no person is required to respond to...

  18. 78 FR 57631 - Information Collection Request Submitted to OMB for Review and Approval; Comment Request; Ambient...

    Science.gov (United States)

    2013-09-19

    ... AGENCY Information Collection Request Submitted to OMB for Review and Approval; Comment Request; Ambient...), Ambient Air Quality Surveillance (Renewal) (EPA ICR No. 0940.27, OMB Control No. 2060-0084) to the Office... approved under the Nitrogen Oxides Ambient Monitoring ICR (OMB 2060-0638, EPA ICR Number 2358.03) and...

  19. Pharmacovigilance of biologicals : dynamics in post-approval safety learning

    NARCIS (Netherlands)

    Vermeer, N.S.

    2015-01-01

    Regulatory decisions to allow new drugs on the market by definition have to accept a certain level of uncertainty about the full benefit-risk balance. Pre-approval studies typically provide information on a limited number of patients over a relative short follow-up period, and handle strict inclusio

  20. 49 CFR 393.7 - Matter incorporated by reference.

    Science.gov (United States)

    2010-10-01

    ... by reference approved for § 393.62(d). (17) Specification for Sound Level Meters, American National... Specification for Strapping, Flat Steel and Seals, American Society for Testing and Materials (ASTM), D3953-97... and copies may be obtained by writing to: American Society for Testing and Materials, 100 Barr...

  1. 46 CFR 10.103 - Incorporation by reference.

    Science.gov (United States)

    2010-10-01

    ..., telephone: + 44 (0)20 7735 7611, http://www.imo.org: (1) The STCW—International Convention on Standards of Training, Certification and Watchkeeping for Seafarers, 1978, as amended 1995 (the STCW Convention or the STCW), incorporation by reference approved for §§ 10.107, 10.109, and 10.231. (2) The...

  2. 46 CFR 15.105 - Incorporation by reference.

    Science.gov (United States)

    2010-10-01

    ... Kingdom, telephone +44(0)20 7735 7611, http://www.imo.org. (1) STCW—The International Convention on Standards of Training, Certification and Watchkeeping for Seafarers, 1978, as amended 1995, (STCW Convention..., Certification and Watchkeeping Code, as amended 1995 (STCW Code), incorporation by reference approved for §§...

  3. Quantum metrology in coarsened measurement reference

    Science.gov (United States)

    Xie, Dong; Xu, Chunling; Wang, An Min

    2017-01-01

    We investigate the role of coarsened measurement reference, which originates from the coarsened reference time and basis, in quantum metrology. When the measurement is based on one common reference basis, the disadvantage of coarsened measurement can be removed by symmetry. Owing to the coarsened reference basis, the entangled state cannot perform better than the product state for a large number of probe particles in estimating the phase. Given a finite uncertainty of the coarsened reference basis, the optimal number of probe particles is obtained. Finally, we prove that the maximally entangled state always achieves better frequency precision in the case of non-Markovian dephasing than that in the case of Markovian dephasing. The product state is more resistant to the interference of the coarsened reference time than the entangled state.

  4. The Herschel Reference Survey

    CERN Document Server

    Boselli, A; Cortese, L; Bendo, G; Chanial, P; Buat, V; Davies, J; Auld, R; Rigby, E; Baes, M; Barlow, M; Bock, J; Bradford, M; Castro-Rodriguez, N; Charlot, S; Clements, D; Cormier, D; Dwek, E; Elbaz, D; Galametz, M; Galliano, F; Gear, W; Glenn, J; Gomez, H; Griffin, M; Hony, S; Isaak, K; Levenson, L; Lu, N; Madden, S; O'Halloran, B; Okumura, K; Oliver, S; Page, M; Panuzzo, P; Papageorgiou, A; Parkin, T; Perez-Fournon, I; Pohlen, M; Rangwala, N; Roussel, H; Rykala, A; Sacchi, N; Sauvage, M; Schulz, B; Schirm, M; Smith, M W L; Spinoglio, L; Stevens, J; Symeonidis, M; Vaccari, M; Vigroux, L; Wilson, C; Wozniak, H; Wright, G; Zeilinger, W

    2010-01-01

    The Herschel Reference Survey is a guaranteed time Herschel key project and will be a benchmark study of dust in the nearby universe. The survey will complement a number of other Herschel key projects including large cosmological surveys that trace dust in the distant universe. We will use Herschel to produce images of a statistically-complete sample of 323 galaxies at 250, 350 and 500 micron. The sample is volume-limited, containing sources with distances between 15 and 25 Mpc and flux limits in the K-band to minimize the selection effects associated with dust and with young high-mass stars and to introduce a selection in stellar mass. The sample spans the whole range of morphological types (ellipticals to late-type spirals) and environments (from the field to the centre of the Virgo Cluster) and as such will be useful for other purposes than our own. We plan to use the survey to investigate (i) the dust content of galaxies as a function of Hubble type, stellar mass and environment, (ii) the connection betwe...

  5. Approval of raxibacumab for the treatment of inhalation anthrax under the US Food and Drug Administration Animal rule

    Directory of Open Access Journals (Sweden)

    Chia-Wei eTsai

    2015-12-01

    Full Text Available On December 14, 2012, the FDA approved raxibacumab, the first product developed under Project BioShield to achieve this milestone, and the first biologic product to be approved through the FDA animal efficacy rule (or Animal Rule. Raxibacumab is approved for the treatment of adult and pediatric patients with inhalational anthrax due to Bacillus anthracis in combination with appropriate antibiotic drugs and for prophylaxis of inhalational anthrax when alternative therapies are not available or are not appropriate. The approval of Raxibacumab illustrates many of the challenges that product developers may encounter when pursuing approval under the Animal Rule and highlights a number of important regulatory and policy issues.

  6. Agricultural Marketing. Student Reference. Volume 12, Number 10. Agdex 810, Catalog Number AG-81-S.

    Science.gov (United States)

    Denker, Robert

    This student guide in agricultural marketing is designed to accompany the lessons in the curriculum unit, "Instructor's Guide in Agricultural Marketing" (CE 025 683). There are six sections in the student guide: (1) Introduction to Marketing; (2) Marketing Cash Grains; (3) Marketing Grain with a Protected Price; (4) Marketing Cash Livestock; (5)…

  7. Introduction to Poultry Production. Instructor Guide [and] Student Reference. Volume 31, Number 3 [and] Number 4.

    Science.gov (United States)

    Raphael, Katherine

    This packet contains both teacher and student materials for a unit on poultry production in vocational agriculture courses and covers the following lessons: (1) overview of the poultry industry; (2) selection and evaluation; (3) production; (4) reproduction; (5) health issues; and (6) processing and marketing. The lessons include the following…

  8. Electronic Approval of Invoices (AEF)

    CERN Multimedia

    2003-01-01

    With a view to the simplification of administrative procedures, AS and FI Divisions have drawn up a new procedure for the electronic approval of invoices via the EDH application. The aim of this new procedure is to rationalise the invoice approval process, notably by eliminating paper copies from the approval circuit. This will simplify the processing of invoices and facilitate their timely settlement, while at the same time maintaining a high level of security. This new procedure, in its current phase, will be gradually implemented from 1 November 2003 onwards. For clarification and further information, please see: http://ais.cern.ch/projs/AEF/help/help.htm . Finance Division, Accounts Payable Tel.: 7.22.95

  9. 77 FR 8865 - Public Water System Supervision Program Approval for the State of Illinois; Tentative Approval

    Science.gov (United States)

    2012-02-15

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Public Water System Supervision Program Approval for the State of Illinois; Tentative Approval... State of Illinois submitted a primacy application for its approved Public Water System...

  10. 40 CFR 1065.1010 - Reference materials.

    Science.gov (United States)

    2010-07-01

    ... and Technology that we have incorporated by reference. The first column lists the number and name of... Procedures,” Amended July 30, 2002, Mobile Source Division, California Air Resources Board 1065.805...

  11. 76 FR 11837 - 30-Day Notice of Proposed Information Collections: DS-4143, Brokering Prior Approval (License...

    Science.gov (United States)

    2011-03-03

    ... Controls, PM/DDTC. Form Number: None. Respondents: Business and Nonprofit Organizations. Estimated Number..., Directorate of Defense Trade Controls, PM/DDTC. Form Number: None. Respondents: Business and Nonprofit... Prior Approval (License). OMB Control Number: 1405-0142. Type of Request: Extension of...

  12. 75 FR 3271 - 30-Day Notice of Proposed Information Collections: DS-4143, Brokering Prior Approval (License...

    Science.gov (United States)

    2010-01-20

    ... Controls, PM/DDTC. Form Number: None. Respondents: Business and Nonprofit Organizations. Estimated Number..., Directorate of Defense Trade Controls, PM/DDTC. Form Number: None. Respondents: Business and Nonprofit... Prior Approval (License). OMB Control Number: 1405-0142. Type of Request: Extension of...

  13. Android quick APIs reference

    CERN Document Server

    Cinar, Onur

    2015-01-01

    The Android Quick APIs Reference is a condensed code and APIs reference for the new Google Android 5.0 SDK. It presents the essential Android APIs in a well-organized format that can be used as a handy reference. You won't find any technical jargon, bloated samples, drawn out history lessons, or witty stories in this book. What you will find is a software development kit and APIs reference that is concise, to the point and highly accessible. The book is packed with useful information and is a must-have for any mobile or Android app developer or programmer. In the Android Quick APIs Refe

  14. Workplace Ergonomics Reference Guide

    Science.gov (United States)

    Workplace Ergonomics Reference Guide 2 nd Edition A Publication of the Computer/Electronic Accommodations Program Real Solutions for Real ... Table of Contents.................................................................................................................................. ... Checklist ........................................................................................................................... 3 Ergonomic ...

  15. 75 FR 54419 - Notice: Elimination of Expiration Dates for Classification Approvals

    Science.gov (United States)

    2010-09-07

    ... implementation. For instance, explosives assigned EX numbers, and self-reactive materials and organic peroxide... to include all types of classification approvals, including explosives, oxidizing substances, organic peroxide materials and self- reactive substances. PHMSA is changing its policy and eliminating...

  16. Drugs Approved for Hodgkin Lymphoma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for Hodgkin lymphoma. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

  17. Drugs Approved for Multiple Myeloma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for multiple myeloma and other plasma cell neoplasms. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

  18. Drugs Approved for Myeloproliferative Neoplasms

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for myeloproliferative neoplasms. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

  19. Alkylbenzene Project in Xinjiang Approved

    Institute of Scientific and Technical Information of China (English)

    Zhou Weiyong

    1996-01-01

    @@ The feasibility study on alkylbenzene project in Dushanzi, Xinjiang Uygur Autonomous Region, submitted jointly by the government of Xinjiang UygurAutonomous Region and China National Petroleum Corporation (CNPC), has been approved by State Council recently,after pass appraisa l by China International Engineering Consulting Corporation entrusted by State Planning Committee.

  20. Aspect and Reference time

    NARCIS (Netherlands)

    Borik, O.

    2002-01-01

    This thesis provides a theory of aspect in Russian based on the notion of Reference time. The main claim advocated in this study is that there are two types of aspect, predicational/telicity aspect and perspective or Reference time aspect. It is argued that these two types should be carefully distin

  1. Reference class forecasting

    DEFF Research Database (Denmark)

    Flyvbjerg, Bent

    optimisme og misinformation. RCF bygger på teorier, som vandt Daniel Kahneman Nobelprisen i økonomi i 2002. RCF estimerer budgettet for et givet projekt på grundlag af de faktiske udfald for budgetterne i en reference-klasse af projekter. RCF udføres i tre trin: 1. Identifikation af en relevant reference...

  2. Marketing Reference Services.

    Science.gov (United States)

    Norman, O. Gene

    1995-01-01

    Relates the marketing concept to library reference services. Highlights include a review of the literature and an overview of marketing, including research, the marketing mix, strategic plan, marketing plan, and marketing audit. Marketing principles are applied to reference services through the marketing mix elements of product, price, place, and…

  3. Rethinking Virtual Reference

    Science.gov (United States)

    Tenopir, Carol

    2004-01-01

    Virtual reference services seem a natural extension of libraries digital collections and the emphasis on access to the library anytime, anywhere. If patrons use the library from home, it makes sense to provide them with person-to-person online reference. The Library of Congress (LC), OCLC, and several large library systems have developed and…

  4. Reference Service Training Manual.

    Science.gov (United States)

    Mielke, John; Young, William

    This manual is primarily designed as an orientation program for librarians new to the Reference Services Division at the State University of New York at Albany University Libraries. It contains practical information and some of the procedures necessary for providing service at the reference desk in these libraries. The appendices provide samples…

  5. China Connections Reference Book.

    Science.gov (United States)

    Kalat, Marie B.; Hoermann, Elizabeth F.

    This reference book focuses on six aspects of the geography of the People's Republic of China. They are: territory, governing units, population and land use, waterways, land forms, and climates. Designed as a primary reference, the book explains how the Chinese people and their lifestyles are affected by China's geography. Special components…

  6. Alcohol references on undergraduate males' Facebook profiles.

    Science.gov (United States)

    Egan, Katie G; Moreno, Megan A

    2011-09-01

    Perceived peer alcohol use is a predictor of consumption in college males; frequent references to alcohol on Facebook may encourage alcohol consumption. Content analysis of college males' Facebook profiles identified references to alcohol. The average age of 225 identified profiles was 19.9 years. Alcohol references were present on 85.3% of the profiles; the prevalence of alcohol was similar across each undergraduate grade. The average number of alcohol references per profile was 8.5 but increased with undergraduate year (p = .003; confidence interval = 1.5, 7.5). Students who were of legal drinking age referenced alcohol 4.5 times more than underage students, and an increase in number of Facebook friends was associated with an increase in displayed alcohol references (p < .001; confidence interval = 0.009, 0.02). Facebook is widely used in the college population; widespread alcohol displays on Facebook may influence social norms and cause increases in male college students' alcohol use.

  7. Number of Compositions and Convolved Fibonacci numbers

    OpenAIRE

    Janjic, Milan

    2010-01-01

    We consider two type of upper Hessenberg matrices which determinants are Fibonacci numbers. Calculating sums of principal minors of the fixed order of the first type leads us to convolved Fibonacci numbers. Some identities for these and for Fibonacci numbers are proved. We also show that numbers of compositions of a natural number with fixed number of ones appear as coefficients of characteristic polynomial of a Hessenberg matrix which determinant is a Fibonacci number. We derive the explicit...

  8. Number of Compositions and Convolved Fibonacci numbers

    CERN Document Server

    Janjic, Milan

    2010-01-01

    We consider two type of upper Hessenberg matrices which determinants are Fibonacci numbers. Calculating sums of principal minors of the fixed order of the first type leads us to convolved Fibonacci numbers. Some identities for these and for Fibonacci numbers are proved. We also show that numbers of compositions of a natural number with fixed number of ones appear as coefficients of characteristic polynomial of a Hessenberg matrix which determinant is a Fibonacci number. We derive the explicit formula for the number of such compositions, in terms of convolutions of Fibonacci numbers.

  9. Collaborating on Referring Expressions

    CERN Document Server

    Heeman, P A; Heeman, Peter A.; Hirst, Graeme

    1995-01-01

    This paper presents a computational model of how conversational participants collaborate in order to make a referring action successful. The model is based on the view of language as goal-directed behavior. We propose that the content of a referring expression can be accounted for by the planning paradigm. Not only does this approach allow the processes of building referring expressions and identifying their referents to be captured by plan construction and plan inference, it also allows us to account for how participants clarify a referring expression by using meta-actions that reason about and manipulate the plan derivation that corresponds to the referring expression. To account for how clarification goals arise and how inferred clarification plans affect the agent, we propose that the agents are in a certain state of mind, and that this state includes an intention to achieve the goal of referring and a plan that the agents are currently considering. It is this mental state that sanctions the adoption of g...

  10. 32 CFR 552.77 - Suspension approval.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Suspension approval. 552.77 Section 552.77 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY RESERVATIONS AND....77 Suspension approval. The installation commander will personally approve all cases in...

  11. 40 CFR 123.61 - Approval process.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Approval process. 123.61 Section 123... REQUIREMENTS Program Approval, Revision, and Withdrawal § 123.61 Approval process. (a) After determining that a...; and (6) Briefly outline the fundamental aspects of the State's proposed program, and the process...

  12. 40 CFR 145.31 - Approval process.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Approval process. 145.31 Section 145.31 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE UIC PROGRAM REQUIREMENTS Program Approval, Revision and Withdrawal § 145.31 Approval process....

  13. 12 CFR 611.510 - Approval procedures.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Approval procedures. 611.510 Section 611.510 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ORGANIZATION Transfer of Authorities § 611.510 Approval procedures. (a) Upon receipt of approval of a resolution by the Farm...

  14. CSS Pocket Reference

    CERN Document Server

    Meyer, Eric

    2011-01-01

    When you're working with CSS and need a quick answer, CSS Pocket Reference delivers. This handy, concise book provides all of the essential information you need to implement CSS on the fly. Ideal for intermediate to advanced web designers and developers, the 4th edition is revised and updated for CSS3, the latest version of the Cascading Style Sheet specification. Along with a complete alphabetical reference to CSS3 selectors and properties, you'll also find a short introduction to the key concepts of CSS. Based on Cascading Style Sheets: The Definitive Guide, this reference is an easy-to-us

  15. Regular Expression Pocket Reference

    CERN Document Server

    Stubblebine, Tony

    2007-01-01

    This handy little book offers programmers a complete overview of the syntax and semantics of regular expressions that are at the heart of every text-processing application. Ideal as a quick reference, Regular Expression Pocket Reference covers the regular expression APIs for Perl 5.8, Ruby (including some upcoming 1.9 features), Java, PHP, .NET and C#, Python, vi, JavaScript, and the PCRE regular expression libraries. This concise and easy-to-use reference puts a very powerful tool for manipulating text and data right at your fingertips. Composed of a mixture of symbols and text, regular exp

  16. Handbook of reference electrodes

    CERN Document Server

    Inzelt, György; Scholz, Fritz

    2013-01-01

    Reference Electrodes are a crucial part of any electrochemical system, yet an up-to-date and comprehensive handbook is long overdue. Here, an experienced team of electrochemists provides an in-depth source of information and data for the proper choice and construction of reference electrodes. This includes all kinds of applications such as aqueous and non-aqueous solutions, ionic liquids, glass melts, solid electrolyte systems, and membrane electrodes. Advanced technologies such as miniaturized, conducting-polymer-based, screen-printed or disposable reference electrodes are also covered. Essen

  17. STL pocket reference

    CERN Document Server

    Lischner, Ray

    2003-01-01

    The STL Pocket Reference describes the functions, classes, and templates in that part of the C++ standard library often referred to as the Standard Template Library (STL). The STL encompasses containers, iterators, algorithms, and function objects, which collectively represent one of the most important and widely used subsets of standard library functionality. The C++ standard library, even the subset known as the STL, is vast. It's next to impossible to work with the STL without some sort of reference at your side to remind you of template parameters, function invocations, return types--ind

  18. Biomedical Engineering Desk Reference

    CERN Document Server

    Ratner, Buddy D; Schoen, Frederick J; Lemons, Jack E; Dyro, Joseph; Martinsen, Orjan G; Kyle, Richard; Preim, Bernhard; Bartz, Dirk; Grimnes, Sverre; Vallero, Daniel; Semmlow, John; Murray, W Bosseau; Perez, Reinaldo; Bankman, Isaac; Dunn, Stanley; Ikada, Yoshito; Moghe, Prabhas V; Constantinides, Alkis

    2009-01-01

    A one-stop Desk Reference, for Biomedical Engineers involved in the ever expanding and very fast moving area; this is a book that will not gather dust on the shelf. It brings together the essential professional reference content from leading international contributors in the biomedical engineering field. Material covers a broad range of topics including: Biomechanics and Biomaterials; Tissue Engineering; and Biosignal Processing* A hard-working desk reference providing all the essential material needed by biomedical and clinical engineers on a day-to-day basis * Fundamentals, key techniques,

  19. R quick syntax reference

    CERN Document Server

    Tollefson, Margot

    2014-01-01

    The R Quick Syntax Reference is a handy reference book detailing the intricacies of the R language. Not only is R a free, open-source tool, R is powerful, flexible, and has state of the art statistical techniques available. With the many details which must be correct when using any language, however, the R Quick Syntax Reference makes using R easier.Starting with the basic structure of R, the book takes you on a journey through the terminology used in R and the syntax required to make R work. You will find looking up the correct form for an expression quick and easy. With a copy of the R Quick

  20. LINQ Pocket Reference

    CERN Document Server

    Albahari, Joseph

    2008-01-01

    Ready to take advantage of LINQ with C# 3.0? This guide has the detail you need to grasp Microsoft's new querying technology, and concise explanations to help you learn it quickly. And once you begin to apply LINQ, the book serves as an on-the-job reference when you need immediate reminders. All the examples in the LINQ Pocket Reference are preloaded into LINQPad, the highly praised utility that lets you work with LINQ interactively. Created by the authors and free to download, LINQPad will not only help you learn LINQ, it will have you thinking in LINQ. This reference explains: LINQ's ke

  1. Underwater Sound Reference Division

    Data.gov (United States)

    Federal Laboratory Consortium — The Underwater Sound Reference Division (USRD) serves as the U.S. standardizing activity in the area of underwater acoustic measurements, as the National Institute...

  2. Ozone Standard Reference Photometer

    Data.gov (United States)

    Federal Laboratory Consortium — The Standard Reference Photometer (SRP) Program began in the early 1980s as collaboration between NIST and the U.S. Environmental Protection Agency (EPA) to design,...

  3. Reference Climatological Stations

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Reference Climatological Stations (RCS) network represents the first effort by NOAA to create and maintain a nationwide network of stations located only in areas...

  4. Genetics Home Reference: hypermethioninemia

    Science.gov (United States)

    ... C. Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism. Hum Genet. ... healthcare professional . About Genetics Home Reference Site Map Customer Support Selection Criteria for Links USA.gov Copyright ...

  5. Toxicity Reference Database

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Toxicity Reference Database (ToxRefDB) contains approximately 30 years and $2 billion worth of animal studies. ToxRefDB allows scientists and the interested...

  6. Enterprise Reference Library

    Science.gov (United States)

    Bickham, Grandin; Saile, Lynn; Havelka, Jacque; Fitts, Mary

    2011-01-01

    Introduction: Johnson Space Center (JSC) offers two extensive libraries that contain journals, research literature and electronic resources. Searching capabilities are available to those individuals residing onsite or through a librarian s search. Many individuals have rich collections of references, but no mechanisms to share reference libraries across researchers, projects, or directorates exist. Likewise, information regarding which references are provided to which individuals is not available, resulting in duplicate requests, redundant labor costs and associated copying fees. In addition, this tends to limit collaboration between colleagues and promotes the establishment of individual, unshared silos of information The Integrated Medical Model (IMM) team has utilized a centralized reference management tool during the development, test, and operational phases of this project. The Enterprise Reference Library project expands the capabilities developed for IMM to address the above issues and enhance collaboration across JSC. Method: After significant market analysis for a multi-user reference management tool, no available commercial tool was found to meet this need, so a software program was built around a commercial tool, Reference Manager 12 by The Thomson Corporation. A use case approach guided the requirements development phase. The premise of the design is that individuals use their own reference management software and export to SharePoint when their library is incorporated into the Enterprise Reference Library. This results in a searchable user-specific library application. An accompanying share folder will warehouse the electronic full-text articles, which allows the global user community to access full -text articles. Discussion: An enterprise reference library solution can provide a multidisciplinary collection of full text articles. This approach improves efficiency in obtaining and storing reference material while greatly reducing labor, purchasing and

  7. Electronics engineer's reference book

    CERN Document Server

    Turner, L W

    1976-01-01

    Electronics Engineer's Reference Book, 4th Edition is a reference book for electronic engineers that reviews the knowledge and techniques in electronics engineering and covers topics ranging from basics to materials and components, devices, circuits, measurements, and applications. This edition is comprised of 27 chapters; the first of which presents general information on electronics engineering, including terminology, mathematical equations, mathematical signs and symbols, and Greek alphabet and symbols. Attention then turns to the history of electronics; electromagnetic and nuclear radiatio

  8. Reference Based Genome Compression

    OpenAIRE

    Chern, Bobbie; Ochoa, Idoia; Manolakos, Alexandros; No, Albert; Venkat, Kartik; Weissman, Tsachy

    2012-01-01

    DNA sequencing technology has advanced to a point where storage is becoming the central bottleneck in the acquisition and mining of more data. Large amounts of data are vital for genomics research, and generic compression tools, while viable, cannot offer the same savings as approaches tuned to inherent biological properties. We propose an algorithm to compress a target genome given a known reference genome. The proposed algorithm first generates a mapping from the reference to the target gen...

  9. Nelfinavir: fourth protease inhibitor approved.

    Science.gov (United States)

    1997-01-01

    The Food and Drug Administration (FDA) has granted accelerated approval to nelfinavir in both adult and pediatric formulations. Agouron, the manufacturer, used innovative computerized drug design techniques to discover, design, and refine the nelfinavir molecule. Nelfinavir is marketed under the trade name Viracept, and costs $5,000 per year. Early clinical trials find it to be as powerful as the other protease inhibitors, but with a different resistance profile. The drug has relatively few drug indications; however, several compounds have been contraindicated.

  10. Reference Man anatomical model

    Energy Technology Data Exchange (ETDEWEB)

    Cristy, M.

    1994-10-01

    The 70-kg Standard Man or Reference Man has been used in physiological models since at least the 1920s to represent adult males. It came into use in radiation protection in the late 1940s and was developed extensively during the 1950s and used by the International Commission on Radiological Protection (ICRP) in its Publication 2 in 1959. The current Reference Man for Purposes of Radiation Protection is a monumental book published in 1975 by the ICRP as ICRP Publication 23. It has a wealth of information useful for radiation dosimetry, including anatomical and physiological data, gross and elemental composition of the body and organs and tissues of the body. The anatomical data includes specified reference values for an adult male and an adult female. Other reference values are primarily for the adult male. The anatomical data include much data on fetuses and children, although reference values are not established. There is an ICRP task group currently working on revising selected parts of the Reference Man document.

  11. Oracle Data Dictionary Pocket Reference

    CERN Document Server

    Kreines, David

    2003-01-01

    If you work with Oracle, then you don't need to be told that the data dictionary is large and complex, and grows larger with each new Oracle release. It's one of the basic elements of the Oracle database you interact with regularly, but the sheer number of tables and views makes it difficult to remember which view you need, much less the name of the specific column. Want to make it simpler? The Oracle Data Dictionary Pocket Reference puts all the information you need right at your fingertips. Its handy and compact format lets you locate the table and view you need effortlessly without stoppin

  12. PVWatts Version 1 Technical Reference

    Energy Technology Data Exchange (ETDEWEB)

    Dobos, A. P.

    2013-10-01

    The NREL PVWatts(TM) calculator is a web application developed by the National Renewable Energy Laboratory (NREL) that estimates the electricity production of a grid-connected photovoltaic system based on a few simple inputs. PVWatts combines a number of sub-models to predict overall system performance, and makes several hidden assumptions about performance parameters. This technical reference details the individual sub-models, documents assumptions and hidden parameters, and explains the sequence of calculations that yield the final system performance estimation.

  13. References in the Australasian Medical Journal

    Directory of Open Access Journals (Sweden)

    Prakash Adhikari

    2010-12-01

    Full Text Available BackgroundReferences serve as an important tool in providing credibility to the published literature and to assist retrieval of the cited and related information. This study was done to observe the accuracy of references in articles published in Australasian Medical Journal.Method Fifty references were randomly selected from two different issues of Australasian Medical Journal (AMJ: Volume 3, Number 11, 2010 and Volume 3, Number 10, 2010. The instructions for authors of this journal were examined. References from each article were compared with the original for accuracy, using the following six elements: 1 authors; including spelling, initials, order and number; 2 title, including spelling and punctuation; 3 journal name, including use of correct abbreviation as listed in Index Medicus; 4 year; 5 volume; and 6 page numbers, including first and last page numbers. Citations were considered incorrect if there was an error in any of these six elements. References not cited from indexed journals were excluded. Statistical analysis was done by using frequency and percentage.ResultsResults show that 14.0% references in AMJ were inaccurate. Most common errors were author’s name and journal name. Author’s names were found to be incorrect in 10.0% references while journal name (either incorrect abbreviations or incorrect instructions or punctuation errors were found to be incorrect in 4.0%. Least common error was found in writing the title of the article (2.0%. There were no errors found in other elements.ConclusionErrors in citing the references are also found in the AMJ. The quoted error in this study (14.0% is comparable to other international literature. The majority of errors are avoidable. So, the authors, editors and the reviewers have to check for any errors seriously before publication in the journal.

  14. The Super Patalan Numbers

    OpenAIRE

    Richardson, Thomas M.

    2014-01-01

    We introduce the super Patalan numbers, a generalization of the super Catalan numbers in the sense of Gessel, and prove a number of properties analagous to those of the super Catalan numbers. The super Patalan numbers generalize the super Catalan numbers similarly to how the Patalan numbers generalize the Catalan numbers.

  15. Locus Reference Genomic sequences: An improved basis for describing human DNA variants

    KAUST Repository

    Dalgleish, Raymond

    2010-04-15

    As our knowledge of the complexity of gene architecture grows, and we increase our understanding of the subtleties of gene expression, the process of accurately describing disease-causing gene variants has become increasingly problematic. In part, this is due to current reference DNA sequence formats that do not fully meet present needs. Here we present the Locus Reference Genomic (LRG) sequence format, which has been designed for the specifi c purpose of gene variant reporting. The format builds on the successful National Center for Biotechnology Information (NCBI) RefSeqGene project and provides a single-fi le record containing a uniquely stable reference DNA sequence along with all relevant transcript and protein sequences essential to the description of gene variants. In principle, LRGs can be created for any organism, not just human. In addition, we recognize the need to respect legacy numbering systems for exons and amino acids and the LRG format takes account of these. We hope that widespread adoption of LRGs - which will be created and maintained by the NCBI and the European Bioinformatics Institute (EBI) - along with consistent use of the Human Genome Variation Society (HGVS)- approved variant nomenclature will reduce errors in the reporting of variants in the literature and improve communication about variants aff ecting human health. Further information can be found on the LRG web site (http://www.lrg-sequence.org). 2010 Dalgleish et al.; licensee BioMed Central Ltd.

  16. Astronomical catalog desk reference, 1994 edition

    Science.gov (United States)

    1994-01-01

    The Astronomical Catalog Desk Reference is designed to aid astronomers in locating machine readable catalogs in the Astronomical Data Center (ADC) archives. The key reference components of this document are as follows: A listing of shortened titles for all catalogs available from the ADC (includes the name of the lead author and year of publication), brief descriptions of over 300 astronomical catalogs, an index of ADC catalog numbers by subject keyword, and an index of ADC catalog numbers by author. The heart of this document is the set of brief descriptions generated by the ADC staff. The 1994 edition of the Astronomical Catalog Desk Reference contains descriptions for over one third of the catalogs in the ADC archives. Readers are encouraged to refer to this section for concise summaries of those catalogs and their contents.

  17. New celestial reference system

    Science.gov (United States)

    Seidelmann, P. K.; Kaplan, G. H.; van Flandern, T. C.

    It is pointed out that the IAU (1976) System of Astronomical Constants, the FK5 and new lunar and planetary theories are being introduced in 1984. The investigation and planning for the transition have revealed the complex interdependencies between observational techniques and the reference systems and their strong link to the rotating and orbiting earth. Details for the conversion to the new system are given. The concepts for a future reference system are developed, based on separating the real motions involved in such a way that observations from various moving platforms can be related to the appropriate coordinate system without involving motions that are not intrinsically involved in the observations. As a consequence, the reference systems determined or used in space, while affected by aberration and parallax, would logically be defined with no dependence on precession, nutation, polar motion, or Universal Time, all of which are concerned with motions of the earth's surface.

  18. Setting reference targets

    Energy Technology Data Exchange (ETDEWEB)

    Ruland, R.E.

    1997-04-01

    Reference Targets are used to represent virtual quantities like the magnetic axis of a magnet or the definition of a coordinate system. To explain the function of reference targets in the sequence of the alignment process, this paper will first briefly discuss the geometry of the trajectory design space and of the surveying space, then continue with an overview of a typical alignment process. This is followed by a discussion on magnet fiducialization. While the magnetic measurement methods to determine the magnetic centerline are only listed (they will be discussed in detail in a subsequent talk), emphasis is given to the optical/mechanical methods and to the task of transferring the centerline position to reference targets.

  19. Reference Based Genome Compression

    CERN Document Server

    Chern, Bobbie; Manolakos, Alexandros; No, Albert; Venkat, Kartik; Weissman, Tsachy

    2012-01-01

    DNA sequencing technology has advanced to a point where storage is becoming the central bottleneck in the acquisition and mining of more data. Large amounts of data are vital for genomics research, and generic compression tools, while viable, cannot offer the same savings as approaches tuned to inherent biological properties. We propose an algorithm to compress a target genome given a known reference genome. The proposed algorithm first generates a mapping from the reference to the target genome, and then compresses this mapping with an entropy coder. As an illustration of the performance: applying our algorithm to James Watson's genome with hg18 as a reference, we are able to reduce the 2991 megabyte (MB) genome down to 6.99 MB, while Gzip compresses it to 834.8 MB.

  20. 19 CFR 142.44 - Entry number range.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Entry number range. 142.44 Section 142.44 Customs... (CONTINUED) ENTRY PROCESS Line Release § 142.44 Entry number range. After an application for Line Release has received final approval, filers must provide the port director, in writing, with a range of entry...

  1. HTML & XHTML Pocket Reference

    CERN Document Server

    Robbins, Jennifer

    2010-01-01

    After years of using spacer GIFs, layers of nested tables, and other improvised solutions for building your web sites, getting used to the more stringent standards-compliant design can be intimidating. HTML and XHTML Pocket Reference is the perfect little book when you need answers immediately. Jennifer Niederst-Robbins, author Web Design in a Nutshell, has revised and updated the fourth edition of this pocket guide by taking the top 20% of vital reference information from her Nutshell book, augmenting it judiciously, cross-referencing everything, and organizing it according to the most com

  2. Perl Pocket Reference

    CERN Document Server

    Vromans, Johan

    2011-01-01

    If you have a Perl programming question, you'll find the answer quickly in this handy, easy-to-use quick reference. The Perl Pocket Reference condenses and organizes stacks of documentation down to the most essential facts, so you can find what you need in a heartbeat. Updated for Perl 5.14, the 5th edition provides a summary of Perl syntax rules and a complete list of operators, built-in functions, and other features. It's the perfect companion to O'Reilly's authoritative and in-depth Perl programming books, including Learning Perl, Programming Perl, and the Perl Cookbook..

  3. Electrical engineer's reference book

    CERN Document Server

    Jones, G R

    2013-01-01

    A long established reference book: radical revision for the fifteenth edition includes complete rearrangement to take in chapters on new topics and regroup the subjects covered for easy access to information.The Electrical Engineer's Reference Book, first published in 1945, maintains its original aims: to reflect the state of the art in electrical science and technology and cater for the needs of practising engineers. Most chapters have been revised and many augmented so as to deal properly with both fundamental developments and new technology and applications that have come to the fore since

  4. Python pocket reference

    CERN Document Server

    Lutz, Mark

    2010-01-01

    This is the book to reach for when you're coding on the fly and need an answer now. It's an easy-to-use reference to the core language, with descriptions of commonly used modules and toolkits, and a guide to recent changes, new features, and upgraded built-ins -- all updated to cover Python 3.X as well as version 2.6. You'll also quickly find exactly what you need with the handy index. Written by Mark Lutz -- widely recognized as the world's leading Python trainer -- Python Pocket Reference, Fourth Edition, is the perfect companion to O'Reilly's classic Python tutorials, also written by Mark

  5. CSS Pocket Reference

    CERN Document Server

    Meyer, Eric A

    2007-01-01

    They say that good things come in small packages, and it's certainly true for this edition of CSS Pocket Reference. Completely revised and updated to reflect the latest Cascading Style Sheet specifications in CSS 2.1, this indispensable little book covers the most essential information that web designers and developers need to implement CSS effectively across all browsers. Inside, you'll find: A short introduction to the key concepts of CSS A complete alphabetical reference to all CSS 2.1 selectors and properties A chart displaying detailed information about CSS support for every style ele

  6. bash Quick Reference

    CERN Document Server

    Robbins, Arnold

    2008-01-01

    In this quick reference, you'll find everything you need to know about the bash shell. Whether you print it out or read it on the screen, this PDF gives you the answers to the annoying questions that always come up when you're writing shell scripts: What characters do you need to quote? How do you get variable substitution to do exactly what you want? How do you use arrays? It's also helpful for interactive use. If you're a Unix user or programmer, or if you're using bash on Windows, you'll find this quick reference indispensable.

  7. JDBC Pocket Reference

    CERN Document Server

    Bales, Donald

    2003-01-01

    JDBC--the Java Database Connectivity specification--is a complex set of application programming interfaces (APIs) that developers need to understand if they want their Java applications to work with databases. JDBC is so complex that even the most experienced developers need to refresh their memories from time to time on specific methods and details. But, practically speaking, who wants to stop and thumb through a weighty tutorial volume each time a question arises? The answer is the JDBC Pocket Reference, a data-packed quick reference that is both a time-saver and a lifesaver. The JDBC P

  8. Beyond natural numbers: Representation of negative numbers in the parietal cortex

    OpenAIRE

    Kristen Pilner Blair; Miriam eRosenberg-Lee; Tsang, Jessica M.; Schwartz, Daniel L.; Vinod eMenon

    2012-01-01

    Unlike natural numbers, negative numbers do not have natural physical referents. How does the brain represent such abstract mathematical concepts? Two competing hypotheses regarding representational systems for negative numbers are a rule-based model, in which symbolic rules are applied to negative numbers to translate them into positive numbers when assessing magnitudes, and an expanded magnitude model, in which negative numbers have a distinct magnitude representation. Using an event-relate...

  9. Impressive Words: Linguistic Predictors of Public Approval of the U.S. Congress

    Science.gov (United States)

    Decter-Frain, Ari; Frimer, Jeremy A.

    2016-01-01

    What type of language makes the most positive impression within a professional setting? Is competent/agentic language or warm/communal language more effective at eliciting social approval? We examined this basic social cognitive question in a real world context using a “big data” approach—the recent record-low levels of public approval of the U.S. Congress. Using Linguistic Inquiry and Word Count (LIWC), we text analyzed all 123+ million words spoken by members of the U.S. House of Representatives during floor debates between 1996 and 2014 and compared their usage of various classes of words to their public approval ratings over the same time period. We found that neither agentic nor communal language positively predicted public approval. However, this may be because communion combines two disparate social motives (belonging and helping). A follow-up analysis found that the helping form of communion positively predicted public approval, and did so more strongly than did agentic language. Next, we conducted an exploratory analysis, examining which of the 63 standard LIWC categories predict public approval. We found that the public approval of Congress was highest when politicians used tentative language, expressed both positive emotion and anxiety, and used human words, numbers, prepositions, numbers, and avoided conjunctions and the use of second-person pronouns. These results highlight the widespread primacy of warmth over competence as the primary dimensions of social cognition. PMID:26941691

  10. References on Sustainable Buildings

    OpenAIRE

    2005-01-01

    This web site is developed with the aim to promote sustainable design and planning of buildings. Selected references including books, reports, audio/visual materials and journals are listed. Most of the materials can be found in the HKU Libraries. To facilitate retrieval, links are provided to the library catalogue system for further information and study.

  11. Reference-Dependent Sympathy

    Science.gov (United States)

    Small, Deborah A.

    2010-01-01

    Natural disasters and other traumatic events often draw a greater charitable response than do ongoing misfortunes, even those that may cause even more widespread misery, such as famine or malaria. Why is the response disproportionate to need? The notion of reference dependence critical to Prospect Theory (Kahneman & Tversky, 1979) maintains that…

  12. The Reference Encounter Model.

    Science.gov (United States)

    White, Marilyn Domas

    1983-01-01

    Develops model of the reference interview which explicitly incorporates human information processing, particularly schema ideas presented by Marvin Minsky and other theorists in cognitive processing and artificial intelligence. Questions are raised concerning use of content analysis of transcribed verbal protocols as methodology for studying…

  13. Selecting a Reference Object

    Science.gov (United States)

    Miller, Jared E.; Carlson, Laura A.; Hill, Patrick L.

    2011-01-01

    One way to describe the location of an object is to relate it to another object. Often there are many nearby objects, each of which could serve as a candidate to be the reference object. A common theoretical assumption is that features that make a given object salient relative to the candidate set are instrumental in determining which is selected.…

  14. X Python reference manual

    NARCIS (Netherlands)

    Mullender, K.S.

    1995-01-01

    This document describes the built-in types, exceptions, and functions of the X windows extension to Python. It assumes basic knowledge about the Python language and access to the X windows documentation. For an informal introduction to the language, see the Python Tutorial. The Python Reference Manu

  15. Python library reference

    NARCIS (Netherlands)

    Rossum, G. van

    1995-01-01

    Python is an extensible, interpreted, object-oriented programming language. It supports a wide range of applications, from simple text processing scripts to interactive WWW browsers. While the Python Reference Manual describes the exact syntax and semantics of the language, it does not describe the

  16. Extending reference assembly models

    DEFF Research Database (Denmark)

    Church, Deanna M.; Schneider, Valerie A.; Steinberg, Karyn Meltz;

    2015-01-01

    The human genome reference assembly is crucial for aligning and analyzing sequence data, and for genome annotation, among other roles. However, the models and analysis assumptions that underlie the current assembly need revising to fully represent human sequence diversity. Improved analysis tools...

  17. International Geomagnetic Reference Field

    DEFF Research Database (Denmark)

    Finlay, Chris; Maus, S.; Beggan, C. D.

    2010-01-01

    The eleventh generation of the International Geomagnetic Reference Field (IGRF) was adopted in December 2009 by the International Association of Geomagnetism and Aeronomy Working Group V‐MOD. It updates the previous IGRF generation with a definitive main field model for epoch 2005.0, a main field...

  18. Synthetic growth reference charts

    NARCIS (Netherlands)

    Hermanussen, Michael; Stec, Karol; Aßmann, Christian; Meigen, Christof; Van Buuren, Stef

    2016-01-01

    Objectives: To reanalyze the between-population variance in height, weight, and body mass index (BMI), and to provide a globally applicable technique for generating synthetic growth reference charts. Methods: Using a baseline set of 196 female and 197 male growth studies published since 1831, common

  19. Role and Reference Grammar.

    Science.gov (United States)

    Van Valin, Robert D., Jr.

    This paper discusses Role and Reference Grammar (RRG), which is a structuralist-formalist theory of grammar. RRG grew out of an attempt to answer two fundamental questions: (1) what would linguistic theory look like if it were based on the analysis of Lakhota, Tagalog, and Dyirbal, rather than on the analysis of English?; and (2) how can the…

  20. Digital Reference Service.

    Science.gov (United States)

    Mon, Lorri

    2000-01-01

    Discusses the increasing demand for digital reference services from government Web sites via email, and describes a partnership between the Government Printing Office and the federal depository library at the University of Illinois at Chicago to create electronic access to the Department of State Foreign Affairs Network (DOSFAN). (Author/LRW)

  1. An Amharic Reference Grammar.

    Science.gov (United States)

    Leslau, Wolf

    This reference grammar presents a structural description of the orthography, phonology, morphology, and syntax of Amharic, the national language of Ethiopia. The Amharic material in this work, designed to prepare the student for speaking and reading the language, appears in both Amharic script and phonetic transcription. See ED 012 044-5 for the…

  2. Companion diagnostics: a regulatory perspective from the last 5 years of molecular companion diagnostic approvals.

    Science.gov (United States)

    Roscoe, Donna M; Hu, Yun-Fu; Philip, Reena

    2015-01-01

    Companion diagnostics are essential for the safe and effective use of the corresponding therapeutic products. The US FDA has approved a number of companion diagnostics used to select cancer patients for treatment with contemporaneously approved novel therapeutics. The processes of co-development and co-approval of a therapeutic product and its companion diagnostic have been a learning experience that continues to evolve. Using several companion diagnostics as examples, this article describes the challenges associated with the scientific, clinical and regulatory hurdles faced by FDA and industry alike. Taken together, this discussion is intended to assist manufacturers toward a successful companion diagnostics development plan.

  3. 77 FR 30216 - Approval and Promulgation of Air Quality Implementation Plans; Maine; Reasonably Available...

    Science.gov (United States)

    2012-05-22

    ... Floor of the Tyson Building, Augusta Mental Health Institute Complex, Augusta, ME 04333-0017. FOR... Environmental protection, Air pollution control, Carbon monoxide, Incorporation by reference, Intergovernmental... AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; Maine;...

  4. 75 FR 8496 - Approval and Promulgation of Implementation Plans; Ohio New Source Review Rules

    Science.gov (United States)

    2010-02-25

    ... AGENCY 40 CFR Part 52 Approval and Promulgation of Implementation Plans; Ohio New Source Review Rules...) construction permit programs to the Ohio State Implementation Plan (SIP) based on the State's November 15, 2005...-31-01(ZZZZZ)(2)(h). This is a reference to the vacated equipment replacement provisions (ERP)....

  5. 78 FR 27065 - Approval and Promulgation of Implementation Plans; North Carolina; Control Techniques Guidelines...

    Science.gov (United States)

    2013-05-09

    ... Subjects in 40 CFR Part 52 Environmental protection, Air pollution control, Incorporation by reference... citation Title/subject effective date EPA approval date Explanation Subchapter 2D Air Pollution Control... citation of and Plastic Parts publication]. Coatings. Sect .0968 Automobile and Light 9/1/2010...

  6. 75 FR 69884 - Approval and Promulgation of Implementation Plans; Texas; Emissions Banking and Trading of...

    Science.gov (United States)

    2010-11-16

    ..., 2002, the TNRCC also adopted revisions to the Emission Credit Banking and Trading Program (referred to... 101, Subchapter H, Division 3, Section 101.357, and the Discrete Emission Credit Banking and Trading... AGENCY 40 CFR Part 52 Approval and Promulgation of Implementation Plans; Texas; Emissions Banking...

  7. On Number of Compositions of Natural Numbers

    CERN Document Server

    Janjic, Milan

    2010-01-01

    We first give a combinatorial interpretation of coefficients of Chebyshev polynomials, which allows us to connect them with compositions of natural numbers. Then we describe a relationship between the number of compositions of a natural number in which a certain number of parts are p-1, and other parts are not less than p with compositions in which all parts are not less than p. Then we find a relationship between principal minors of a type of Hessenberg matrices and compositions of natural numbers.

  8. On Multiplying Negative Numbers.

    Science.gov (United States)

    Crowley, Mary L.; Dunn, Kenneth A.

    1985-01-01

    Comments on the history of negative numbers, some methods that can be used to introduce the multiplication of negative numbers to students, and an explanation of why the product of two negative numbers is a positive number are included. (MNS)

  9. OMB Recommended vs Approved Operating Budget

    Data.gov (United States)

    Montgomery County of Maryland — This dataset includes the Fiscal Year 2015 County Executive Recommended and County Council Approved operating budgets for Montgomery County, for comparison purposes....

  10. Marketing Approval of Ethical Kampo Medicines.

    Science.gov (United States)

    Hakamatsuka, Takashi

    2017-01-01

     Kampo medicine is an original traditional medicine in Japan. Currently, 148 ethical Kampo formulations (Kampo prescription drugs) are registered in the National Health Insurance Price List. Kampo medicines can be prescribed under the national insurance system, which shows that they are part of conventional medicine in Japan. Japan has a unified drug approval system that does not distinguish between Western and Kampo medicines, and both are subject to the same regulations. The application for the market approval of ethical Kampo medicines is based on the general notification for drugs, i.e., "Handling of Ethical Combination Drugs" in "Precautions Necessary When Applying for Drug Marketing Approval" (Yakushokushinsa Notification No. 1121-12 of November 21, 2014). Furthermore, applications for the market approval of ethical Kampo medicines should follow the Kampo-specific notification of "Handling of Ethical Kampo Medicines" (Yakushin Notification No. 804 of June 25, 1980). Data from comparative studies with standard decoctions must be submitted with approval applications according to Yakushin 2 Notification No. 120 of May 31, 1985. The safety, efficacy, and quality of Kampo medicines are comprehensively assured by the Japanese Pharmacopoeia, Good Manufacturing Practice, Good Agricultural and Collection Practices, marketing approval certificate, approval standard, and pharmacovigilance. I believe that the basic framework for the market approval of ethical Kampo medicines has been established as described above. The key factors for the practical application of superior manufacturing technology and research achievements and the promotion of drug development are the specific guidelines for the approval of drugs of herbal origin.

  11. 30 CFR 18.81 - Field modification of approved (permissible) equipment; application for approval of modification...

    Science.gov (United States)

    2010-07-01

    ... TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Machines Assembled With Certified or Explosion-Proof Components, Field Modifications of Approved Machines... and Certification Center, 765 Technology Drive, Triadelphia, WV 26059. (b) Proposed...

  12. OSH technical reference manual

    Energy Technology Data Exchange (ETDEWEB)

    1993-11-01

    In an evaluation of the Department of Energy (DOE) Occupational Safety and Health programs for government-owned contractor-operated (GOCO) activities, the Department of Labor`s Occupational Safety and Health Administration (OSHA) recommended a technical information exchange program. The intent was to share written safety and health programs, plans, training manuals, and materials within the entire DOE community. The OSH Technical Reference (OTR) helps support the secretary`s response to the OSHA finding by providing a one-stop resource and referral for technical information that relates to safe operations and practice. It also serves as a technical information exchange tool to reference DOE-wide materials pertinent to specific safety topics and, with some modification, as a training aid. The OTR bridges the gap between general safety documents and very specific requirements documents. It is tailored to the DOE community and incorporates DOE field experience.

  13. All Square Chiliagonal Numbers

    Science.gov (United States)

    A?iru, Muniru A.

    2016-01-01

    A square chiliagonal number is a number which is simultaneously a chiliagonal number and a perfect square (just as the well-known square triangular number is both triangular and square). In this work, we determine which of the chiliagonal numbers are perfect squares and provide the indices of the corresponding chiliagonal numbers and square…

  14. Maritime Claims Reference Manual

    Science.gov (United States)

    1990-07-12

    8217 75028.8’ 28 Isla Conica 51010.7’ 75015.5’ 29 Roca Santa Lucia 51037.0’ 75.21.0’ 30 Roca Galicia 52003.4’ 75009.0’ 31 Islotes Evangelistas 52023.6’ 75005.6...amendment to the Marine Space Act which, inter alia , deletes reference to Rotuma as an archipelago. Instead, the waters within the baselines are

  15. Electrical engineer's reference book

    CERN Document Server

    Laughton, M A

    1985-01-01

    Electrical Engineer's Reference Book, Fourteenth Edition focuses on electrical engineering. The book first discusses units, mathematics, and physical quantities, including the international unit system, physical properties, and electricity. The text also looks at network and control systems analysis. The book examines materials used in electrical engineering. Topics include conducting materials, superconductors, silicon, insulating materials, electrical steels, and soft irons and relay steels. The text underscores electrical metrology and instrumentation, steam-generating plants, turbines

  16. GDB Pocket Reference

    CERN Document Server

    Robbins, Arnold

    2009-01-01

    The GNU debugger is valuable for testing, fixing, and retesting software because it allows you to see exactly what's going on inside of a program as it's executing. This new pocket reference shows you how to specify a target for debugging, perform a careful examination to find the cause of program failure, and make quick changes for further testing. The guide covers several popular programming languages.

  17. Open SHMEM Reference Implementation

    Energy Technology Data Exchange (ETDEWEB)

    2016-05-12

    OpenSHMEM is an effort to create a specification for a standardized API for parallel programming in the Partitioned Global Address Space. Along with the specification the project is also creating a reference implementation of the API. This implementation attempts to be portable, to allow it to be deployed in multiple environments, and to be a starting point for implementations targeted to particular hardware platforms. It will also serve as a springboard for future development of the API.

  18. Electroacoustical reference data

    CERN Document Server

    Eargle, John M

    2002-01-01

    The need for a general collection of electroacoustical reference and design data in graphical form has been felt by acousticians and engineers for some time. This type of data can otherwise only be found in a collection of handbooks. Therefore, it is the author's intention that this book serve as a single source for many electroacoustical reference and system design requirements. In form, the volume closely resembles Frank Massa's Acoustic Design Charts, a handy book dating from 1942 that has long been out of print. The basic format of Massa's book has been followed here: For each entry, graphical data are presented on the right page, while text, examples, and refer­ ences appear on the left page. In this manner, the user can solve a given problem without thumbing from one page to the next. All graphs and charts have been scaled for ease in data entry and reading. The book is divided into the following sections: A. General Acoustical Relationships. This section covers the behavior of sound transmis­ sion in...

  19. Automated Question Triage for Social Reference: A Study of Adopting Decision Factors from Digital Reference

    Science.gov (United States)

    Park, Jong Do

    2013-01-01

    The increasing popularity of Social Reference (SR) services has enabled a corresponding growth in the number of users engaging in them as well as in the number of questions submitted to the services. However, the efficiency and quality of the services are being challenged because a large quantity of the questions have not been answered or…

  20. Persistent Web References – Best Practices and New Suggestions

    DEFF Research Database (Denmark)

    Zierau, Eld; Nyvang, Caroline; Kromann, Thomas Hvid

    for various research fields, since an increasing number of references point to resources that only exist on the web. However, present practices using URL and date reference cannot be regarded as persistent due to the volatile nature of the Internet, - and present practices for references to web archives only...... refer to archive URLs which depends on the web archives access implementations. A major part of the suggested adjustments is a new web reference standard for archived web references (called wPID), which is a supplement to the current practices. The purpose of the standard is to support general, global...

  1. With Reference to Reference Genes: A Systematic Review of Endogenous Controls in Gene Expression Studies.

    Science.gov (United States)

    Chapman, Joanne R; Waldenström, Jonas

    2015-01-01

    The choice of reference genes that are stably expressed amongst treatment groups is a crucial step in real-time quantitative PCR gene expression studies. Recent guidelines have specified that a minimum of two validated reference genes should be used for normalisation. However, a quantitative review of the literature showed that the average number of reference genes used across all studies was 1.2. Thus, the vast majority of studies continue to use a single gene, with β-actin (ACTB) and/or glyceraldehyde 3-phosphate dehydrogenase (GAPDH) being commonly selected in studies of vertebrate gene expression. Few studies (15%) tested a panel of potential reference genes for stability of expression before using them to normalise data. Amongst studies specifically testing reference gene stability, few found ACTB or GAPDH to be optimal, whereby these genes were significantly less likely to be chosen when larger panels of potential reference genes were screened. Fewer reference genes were tested for stability in non-model organisms, presumably owing to a dearth of available primers in less well characterised species. Furthermore, the experimental conditions under which real-time quantitative PCR analyses were conducted had a large influence on the choice of reference genes, whereby different studies of rat brain tissue showed different reference genes to be the most stable. These results highlight the importance of validating the choice of normalising reference genes before conducting gene expression studies.

  2. Reference blindness: the influence of references on trust in Wikipedia

    NARCIS (Netherlands)

    Lucassen, Teun; Noordzij, Matthijs L.; Schraagen, Jan Maarten

    2011-01-01

    In this study we show the influence of references on trust in information. We changed the contents of reference lists of Wikipedia articles in such a way that the new references were no longer in any sense related to the topic of the article. Furthermore, the length of the reference list was varied.

  3. 77 FR 34027 - Proposed Extension of Approval of Information Collection; Comment Request-Testing and...

    Science.gov (United States)

    2012-06-08

    ... years from the date of approval by the Office of Management and Budget (OMB), of information collection... to perform each year varies, depending upon the number of carpet styles and the annual volume of... may vary from one to 200, depending upon the number of carpet styles and the annual production...

  4. 77 FR 42548 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

    Science.gov (United States)

    2012-07-19

    ... of Renewed Approval of Information Collection: Commercial Air Tour Operator Reports AGENCY: Federal... INFORMATION: OMB Control Number: 2120-0750. Title: Commercial Air Tour Operator Reports. Form Numbers: There...) of 2000. One of these amendments requires commercial air tour operators conducting tours...

  5. 77 FR 27271 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

    Science.gov (United States)

    2012-05-09

    ... of Renewed Approval of Information Collection: Commercial Air Tour Operator Reports AGENCY: Federal... INFORMATION: OMB Control Number: 2120-0750 Title: Commercial Air Tour Operator Reports Form Numbers: There are... 2000. One of these amendments requires commercial air tour operators conducting tours over...

  6. 14 CFR 21.325 - Export airworthiness approvals.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Export airworthiness approvals. 21.325... AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Export Airworthiness Approvals § 21.325 Export airworthiness approvals. (a) Kinds of approvals. (1) Export airworthiness approval of Class I products is...

  7. Numbers Defy the Law of Large Numbers

    Science.gov (United States)

    Falk, Ruma; Lann, Avital Lavie

    2015-01-01

    As the number of independent tosses of a fair coin grows, the rates of heads and tails tend to equality. This is misinterpreted by many students as being true also for the absolute numbers of the two outcomes, which, conversely, depart unboundedly from each other in the process. Eradicating that misconception, as by coin-tossing experiments,…

  8. Parameterizing by the Number of Numbers

    CERN Document Server

    Fellows, Michael R; Rosamond, Frances A

    2010-01-01

    The usefulness of parameterized algorithmics has often depended on what Niedermeier has called, "the art of problem parameterization". In this paper we introduce and explore a novel but general form of parameterization: the number of numbers. Several classic numerical problems, such as Subset Sum, Partition, 3-Partition, Numerical 3-Dimensional Matching, and Numerical Matching with Target Sums, have multisets of integers as input. We initiate the study of parameterizing these problems by the number of distinct integers in the input. We rely on an FPT result for ILPF to show that all the above-mentioned problems are fixed-parameter tractable when parameterized in this way. In various applied settings, problem inputs often consist in part of multisets of integers or multisets of weighted objects (such as edges in a graph, or jobs to be scheduled). Such number-of-numbers parameterized problems often reduce to subproblems about transition systems of various kinds, parameterized by the size of the system descripti...

  9. 40 CFR 52.1323 - Approval status.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Approval status. 52.1323 Section 52.1323 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... on January 16, 1979 (44 FR 3274) are met. (b) The Administrator approves Rule 10 CSR 10-2.290...

  10. Obinutuzumab breaks through to FDA approval.

    Science.gov (United States)

    2014-01-01

    The U.S. Food and Drug Administration approved the monoclonal antibody obinutuzumab for use with chlorambucil in patients with previously untreated chronic lymphocytic leukemia. The drug is the first to receive approval under the agency's breakthrough therapy designation, created in July 2012.

  11. 46 CFR 154.1005 - Equipment approval.

    Science.gov (United States)

    2010-10-01

    ... carried. (b) Each submerged cargo pump motor installation must be specially approved by the Commandant (CG... FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Design, Construction and Equipment Electrical § 154.1005 Equipment approval. (a) Electrical equipment that is required to be intrinsically safe...

  12. 24 CFR 214.103 - Approval criteria.

    Science.gov (United States)

    2010-04-01

    ... counseling staff must possess a working knowledge of HUD's housing and single-family mortgage insurance... COUNSELING PROGRAM Approval and Disapproval of Housing Counseling Agencies § 214.103 Approval criteria. The... counseling agencies, branches, and affiliates that are included in one application: (a) Nonprofit and...

  13. 38 CFR 21.7220 - Course approval.

    Science.gov (United States)

    2010-07-01

    ...; Pub. L. 98-525) (b) Course approval criteria. In administering benefits payable under 38 U.S.C.... (1) Section 21.4250 (except paragraph (c)(1))—Jurisdiction for course and licensing and certification... study; and (12) Section 21.4268—Approval of licensing and certification tests. (Authority: 38...

  14. 40 CFR 91.6 - Reference materials.

    Science.gov (United States)

    2010-07-01

    ... forth material from the Society of Automotive Engineers which has been incorporated by reference. The... Automotive Engineers International, 400 Commonwealth Dr., Warrendale, PA 15096-0001. Document number and name.... (1) ASTM material. The following table sets forth material from the American Society for Testing...

  15. Generating Application Ontologies from Reference Ontologies

    OpenAIRE

    Shaw, Marianne; Detwiler, Landon T.; Brinkley, James F.; Suciu, Dan

    2008-01-01

    The semantic web provides the possiblity of linking together large numbers of biomedical ontologies. Unfortunately, many of the biomedical ontologies that have been developed are domain-specific and do not share a common structure that will allow them to be easily combined. Reference ontologies provide the necessary ontological framework for linking together these smaller, specialized ontologies.

  16. 40 CFR 92.5 - Reference materials.

    Science.gov (United States)

    2010-07-01

    ... § 92.113 ASTM D 1945-91, Standard Test Method for Analysis of Natural Gas by Gas Chromatography § 92... Supercritical Fluid Chromatography § 92.113 ASTM E 29-93a, Standard Practice for Using Significant Digits in... follows: Document number and name 40 CFR part 92 reference SAE Paper 770141, Optimization of a...

  17. Electronic Reference Works and Library Budgeting Dilemma

    Science.gov (United States)

    Lawal, Ibironke O.

    2007-01-01

    The number of electronic resources has climbed up steadily in recent times. Some of these e-resources are reference sources, mostly in Science, Technology and Medicine (STM), which publishers convert to electronic for obvious reasons. The library budgets for materials usually have two main lines, budget for one time purchase (monographs) and…

  18. A Reference Architecture for Workflow Management Systems

    NARCIS (Netherlands)

    Grefen, Paul; Remmerts de Vries, Remmert

    1998-01-01

    In the workflow management field, fast developments are taking place. A growing number of systems is currently under development, both in academic and commercial environments. Consequently, a wide variety of ad hoc architectures has come into existence. Reference models are necessary, however, to al

  19. Mechanical engineer's reference book

    CERN Document Server

    Parrish, A

    1973-01-01

    Mechanical Engineer's Reference Book: 11th Edition presents a comprehensive examination of the use of Systéme International d' Unités (SI) metrication. It discusses the effectiveness of such a system when used in the field of engineering. It addresses the basic concepts involved in thermodynamics and heat transfer. Some of the topics covered in the book are the metallurgy of iron and steel; screw threads and fasteners; hole basis and shaft basis fits; an introduction to geometrical tolerancing; mechanical working of steel; high strength alloy steels; advantages of making components as castings

  20. XSLT 10 Pocket Reference

    CERN Document Server

    Lenz, Evan

    2008-01-01

    XSLT is an essential tool for converting XML into other kinds of documents: HTML, PDF file, and many others. It's a critical technology for XML-based platforms such as Microsoft .NET, Sun Microsystems' Sun One, as well as for most web browsers and authoring tools. As useful as XSLT is, however, most people have a difficult time getting used to its peculiar characteristics. The ability to use advanced techniques depends on a clear and exact understanding of how XSLT templates work and interact. The XSLT 1.0 Pocket Reference from O'Reilly wants to make sure you achieve that level of understan

  1. Electronics engineer's reference book

    CERN Document Server

    Mazda, F F

    1989-01-01

    Electronics Engineer's Reference Book, Sixth Edition is a five-part book that begins with a synopsis of mathematical and electrical techniques used in the analysis of electronic systems. Part II covers physical phenomena, such as electricity, light, and radiation, often met with in electronic systems. Part III contains chapters on basic electronic components and materials, the building blocks of any electronic design. Part IV highlights electronic circuit design and instrumentation. The last part shows the application areas of electronics such as radar and computers.

  2. Xcode 5 developer reference

    CERN Document Server

    Wentk, Richard

    2014-01-01

    Design, code, and build amazing apps with Xcode 5 Thanks to Apple's awesome Xcode development environment, you can create the next big app for Macs, iPhones, iPads, or iPod touches. Xcode 5 contains gigabytes of great stuff to help you develop for both OS X and iOS devices - things like sample code, utilities, companion applications, documentation, and more. And with Xcode 5 Developer Reference, you now have the ultimate step-by-step guide to it all. Immerse yourself in the heady and lucrative world of Apple app development, see how to tame the latest features and functions, and find loads of

  3. Rails Pocket Reference

    CERN Document Server

    Berry, Eric

    2008-01-01

    Rails 2.1 brings a new level of stability and power to this acclaimed web development framework, but keeping track of its numerous moving parts is still a chore. Rails Pocket Reference offers you a painless alternative to hunting for resources online, with brief yet thorough explanations of the most frequently used methods and structures supported by Rails 2.1, along with key concepts you need to work through the framework's most tangled corners. Organized to help you quickly find what you need, this book will not only get you up to speed on how Rails works, it also provides a handy referenc

  4. VBScript pocket reference

    CERN Document Server

    Lomax, Paul; Petrusha, Ron

    2008-01-01

    Microsoft's Visual Basic Scripting Edition (VBScript), a subset of Visual Basic for Applications, is a powerful language for Internet application development, where it can serve as a scripting language for server-side, client-side, and system scripting. Whether you're developing code for Active Server Pages, client-side scripts for Internet Explorer, code for Outlook forms, or scripts for Windows Script Host, VBScript Pocket Reference will be your constant companion. Don't let the pocket-friendly format fool you. Based on the bestsellingVBScript in a Nutshell, this small book details every V

  5. Sensor employing internal reference electrode

    DEFF Research Database (Denmark)

    2013-01-01

    The present invention concerns a novel internal reference electrode as well as a novel sensing electrode for an improved internal reference oxygen sensor and the sensor employing same.......The present invention concerns a novel internal reference electrode as well as a novel sensing electrode for an improved internal reference oxygen sensor and the sensor employing same....

  6. Number words and number symbols a cultural history of numbers

    CERN Document Server

    Menninger, Karl

    1992-01-01

    Classic study discusses number sequence and language and explores written numerals and computations in many cultures. "The historian of mathematics will find much to interest him here both in the contents and viewpoint, while the casual reader is likely to be intrigued by the author's superior narrative ability.

  7. Coal data: A reference

    Energy Technology Data Exchange (ETDEWEB)

    1995-02-01

    This report, Coal Data: A Reference, summarizes basic information on the mining and use of coal, an important source of energy in the US. This report is written for a general audience. The goal is to cover basic material and strike a reasonable compromise between overly generalized statements and detailed analyses. The section ``Supplemental Figures and Tables`` contains statistics, graphs, maps, and other illustrations that show trends, patterns, geographic locations, and similar coal-related information. The section ``Coal Terminology and Related Information`` provides additional information about terms mentioned in the text and introduces some new terms. The last edition of Coal Data: A Reference was published in 1991. The present edition contains updated data as well as expanded reviews and additional information. Added to the text are discussions of coal quality, coal prices, unions, and strikes. The appendix has been expanded to provide statistics on a variety of additional topics, such as: trends in coal production and royalties from Federal and Indian coal leases, hours worked and earnings for coal mine employment, railroad coal shipments and revenues, waterborne coal traffic, coal export loading terminals, utility coal combustion byproducts, and trace elements in coal. The information in this report has been gleaned mainly from the sources in the bibliography. The reader interested in going beyond the scope of this report should consult these sources. The statistics are largely from reports published by the Energy Information Administration.

  8. Directory of Certificates of Compliance for radioactive materials packages: Report of NRC approved packages. Volume 1, Revision 18

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-10-01

    The purpose of this directory is to make available a convenient source of information on packagings which have been approved by the US Nuclear Regulatory Commission. To assist in identifying packaging, an index by Model Number and corresponding Certificate of Compliance Number is included at the front of Volumes 1 and 2. An alphabetical listing by user name is included in the back of Volume 3 of approved QA programs. The reports include a listing of all users of each package design and approved QA programs prior to the publication date.

  9. Normal Fuzzy Number Evaluationon Soil Heavy Metals in the Water-Level Fluctuation Zones and Supralittoral Reference Zones of Xiangxi River%香溪河消落带及其上缘土壤重金属的正态模糊数评价

    Institute of Scientific and Technical Information of China (English)

    张海锋; 李晓玲; 戴泽龙; 胥焘; 罗玉红; 黄应平

    2016-01-01

    分别于2014年4,9月和2015年2月对三峡库区香溪河消落带(海拔165~175 m)及其上缘(海拔175~185 m)野外采集土样108个,采用原子吸收光谱法测定土壤重金属(Cr,Pb,Cu和Cd)的含量,用模糊污染指数模型-正态模糊数的地累积指数对不同出露时期的消落带及其上缘的土壤重金属含量进行评价.对出露前期(2014年4月),出露后期(2014年9月)和水淹出露期(2015年2月)的消落带上层土(0~20 cm)和下层土(20~40cm)的分析表明,Cd含量在出露后期达到最大值(上、下层土壤含量分别为1.21,0.94 mg·kg-1),在水淹出露时达到最小值(上、下层土壤含量分别为1.04,0.90 mg·kg-1).基于该方法评价结果,香溪河消落带及其上缘中Cd为中度污染,Cu和Pb均为轻度污染,Cr为清洁水平,综合评价为轻度污染等级.%A total of 108 soil samples got in April,September 2014 and February 2015 were collected from the water level fluctuation zones (WLFZs,165-175 m above MSL) and supralittoral reference zones(SRZs,175-185 m above MSL) along Xiangxi River,Three Gorges Reservoir.The heavy metal (Cr,Pb,Cu and Cd) concentrations of the soils were determined by the graphite furnace atomic absorption spectroscopy(GFAAS).A fuzzy model for the pollution index called geo-accumulation indexes based on normal fuzzy numbers (GIFNs) was employed for the determination of element contamination in different periods of exposure to heavy metals in the WLFZs and SRZs.The results showed that among the early exposure period (April 2014),the late exposure period (in September 2014) and the exposure after submergence (February 2015) with topsoil (0-20 cm) and subsoil (20-40 cm),Cd content reached the maximum value (the topsoil and subsoil heavy metal content were 1.21,0.94 mg · kg-1) in the late exposure period and reached a minimum value in the exposure period after submergence (the topsoil and subsoil heavy metal content were 1.04,0.90 mg · kg-1);Based on GIFNs for

  10. Those fascinating numbers

    CERN Document Server

    Koninck, Jean-Marie De

    2009-01-01

    Who would have thought that listing the positive integers along with their most remarkable properties could end up being such an engaging and stimulating adventure? The author uses this approach to explore elementary and advanced topics in classical number theory. A large variety of numbers are contemplated: Fermat numbers, Mersenne primes, powerful numbers, sublime numbers, Wieferich primes, insolite numbers, Sastry numbers, voracious numbers, to name only a few. The author also presents short proofs of miscellaneous results and constantly challenges the reader with a variety of old and new n

  11. New, expanded, and modified use of approved antineoplastic agents in ovarian cancer.

    Science.gov (United States)

    Markman, Maurie

    2007-02-01

    Over the past several years, clinical research efforts in ovarian cancer employing a number of U.S. Food and Drug Administration (FDA)-approved antineoplastic agents have permitted the development of approaches that both improve the effectiveness and decrease the toxicities of systemic therapy of ovarian cancer. These initiatives, including prospective trials and retrospective examinations of large clinical experience, have involved agents previously approved by the FDA for use in ovarian cancer (e.g., cisplatin, paclitaxel, topotecan, and liposomal doxorubicin) and the development of new strategies for drugs approved for other malignant conditions (e.g., gemcitabine, docetaxel, etoposide, irinotecan, vinorelbine, and bevacizumab). It can be anticipated that future studies involving novel approved agents will further expand the oncologist's weapons against ovarian cancer.

  12. The OTIS Reference Manual

    CERN Document Server

    Deppe, H; Trunk, U; Uwer, U

    2008-01-01

    This document describes the port definitions, electrical specifications, modes of operation and programming sequences of the OTIS TDC. The chip is developed for the Outer Tracker of the LHCb experiment. OTIS1.0 is the first full-scale prototype of this 32 channel TDC and has been submitted in April 2002 in a standard 0.25µm CMOS process. Within the clock driven architecture of the chip a DLL provides the reference for the drift time measurement. The drift time data of every channel is stored in the pipeline memory until a trigger decision arrives. A control unit provides memory and trigger management and handles data transmission to the subsequent DAQ stage. The latest chip version is OTIS1.3.

  13. Magnetohydrodynamic inertial reference system

    Science.gov (United States)

    Eckelkamp-Baker, Dan; Sebesta, Henry R.; Burkhard, Kevin

    2000-07-01

    Optical platforms increasingly require attitude knowledge and optical instrument pointing at sub-microradian accuracy. No low-cost commercial system exists to provide this level of accuracy for guidance, navigation, and control. The need for small, inexpensive inertial sensors, which may be employed in pointing control systems that are required to satisfy angular line-of-sight stabilization jitter error budgets to levels of 1-3 microradian rms and less, has existed for at least two decades. Innovations and evolutions in small, low-noise inertial angular motion sensor technology and advances in the applications of the global positioning system have converged to allow improvement in acquisition, tracking and pointing solutions for a wide variety of payloads. We are developing a small, inexpensive, and high-performance inertial attitude reference system that uses our innovative magnetohydrodynamic angular rate sensor technology.

  14. Tank characterization reference guide

    Energy Technology Data Exchange (ETDEWEB)

    De Lorenzo, D.S.; DiCenso, A.T.; Hiller, D.B.; Johnson, K.W.; Rutherford, J.H.; Smith, D.J. [Los Alamos Technical Associates, Kennewick, WA (United States); Simpson, B.C. [Westinghouse Hanford Co., Richland, WA (United States)

    1994-09-01

    Characterization of the Hanford Site high-level waste storage tanks supports safety issue resolution; operations and maintenance requirements; and retrieval, pretreatment, vitrification, and disposal technology development. Technical, historical, and programmatic information about the waste tanks is often scattered among many sources, if it is documented at all. This Tank Characterization Reference Guide, therefore, serves as a common location for much of the generic tank information that is otherwise contained in many documents. The report is intended to be an introduction to the issues and history surrounding the generation, storage, and management of the liquid process wastes, and a presentation of the sampling, analysis, and modeling activities that support the current waste characterization. This report should provide a basis upon which those unfamiliar with the Hanford Site tank farms can start their research.

  15. Alcohol References on Undergraduate Males’ Facebook Profiles

    Science.gov (United States)

    Egan, Katie G.; Moreno, Megan A.

    2011-01-01

    Perceived peer alcohol use is a predictor of consumption in college males; frequent references to alcohol on Facebook may encourage alcohol consumption. Content analysis of college males’ Facebook profiles identified references to alcohol. The average age of 225 identified profiles was 19.9 years. Alcohol references were present on 85.3% of the profiles; the prevalence of alcohol was similar across each undergraduate grade. The average number of alcohol references per profile was 8.5 but increased with undergraduate year (p = .003; confidence interval = 1.5, 7.5). Students who were of legal drinking age referenced alcohol 4.5 times more than underage students, and an increase in number of Facebook friends was associated with an increase in displayed alcohol references (p < .001; confidence interval = 0.009, 0.02). Facebook is widely used in the college population; widespread alcohol displays on Facebook may influence social norms and cause increases in male college students’ alcohol use. PMID:21406490

  16. Building Numbers from Primes

    Science.gov (United States)

    Burkhart, Jerry

    2009-01-01

    Prime numbers are often described as the "building blocks" of natural numbers. This article shows how the author and his students took this idea literally by using prime factorizations to build numbers with blocks. In this activity, students explore many concepts of number theory, including the relationship between greatest common factors and…

  17. Introduction to number theory

    CERN Document Server

    Vazzana, Anthony; Garth, David

    2007-01-01

    One of the oldest branches of mathematics, number theory is a vast field devoted to studying the properties of whole numbers. Offering a flexible format for a one- or two-semester course, Introduction to Number Theory uses worked examples, numerous exercises, and two popular software packages to describe a diverse array of number theory topics.

  18. Are Numbers Gendered?

    Science.gov (United States)

    Wilkie, James E. B.; Bodenhausen, Galen V.

    2012-01-01

    We examined the possibility that nonsocial, highly generic concepts are gendered. Specifically, we investigated the gender connotations of Arabic numerals. Across several experiments, we show that the number 1 and other odd numbers are associated with masculinity, whereas the number 2 and other even numbers are associated with femininity, in ways…

  19. δ-FIBONACCI NUMBERS

    OpenAIRE

    Damian Slota; Roman Witula

    2009-01-01

    The scope of the paper is the definition and discussion of the polynomial generalizations of the {sc Fibonacci} numbers called here $delta$-{sc Fibonacci} numbers. Many special identities and interesting relations for these new numbers are presented. Also, different connections between $delta$-{sc Fibonacci} numbers and {sc Fibonacci} and {sc Lucas} numbersare proven in this paper.

  20. Directory of certificates of compliance for radioactive materials packages. Summary report of NRC approved packages

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-10-01

    This directory contains a Summary Report of NRC Approved Packages for radioactive material packages effective September 14, 1979. Purpose of this directory is to make available a convenient source of information on packagings which have been approved by the US Nuclear Regulatory Commission. To assist in identifying packaging, an index by Model Number and corresponding Certificate of Compliance number is included at the back of each volume of the directory. The Summary Report includes a listing of all users of each package design prior to the publication date of the directory.

  1. Hyper Space Complex Number

    OpenAIRE

    Tan, Shanguang

    2007-01-01

    A new kind of numbers called Hyper Space Complex Numbers and its algebras are defined and proved. It is with good properties as the classic Complex Numbers, such as expressed in coordinates, triangular and exponent forms and following the associative and commutative laws of addition and multiplication. So the classic Complex Number is developed from in complex plane with two dimensions to in complex space with N dimensions and the number system is enlarged also.

  2. 76 FR 26616 - Wisconsin: Incorporation by Reference of Approved State Hazardous Waste Management Program

    Science.gov (United States)

    2011-05-09

    ..., 2006/2007 Edition, Sections NR 665.0071(1)(b)6, 666.900-666.905, 666.909, 666.910, 670.007, and 670.427...- 665.1202, chapter NR 665 Appendix I, III, IV, V and VI, sections NR 666.020-666.023, 666.070, 666.080, 666.100-666.112, 666.200-666.206, 666.210, 666.220, 666.225, 666.230,......

  3. 77 FR 59758 - Idaho: Incorporation by Reference of Approved State Hazardous Waste Management Program

    Science.gov (United States)

    2012-10-01

    ... Siting Act'', published in 2002 by the Michie Company, Law Publishers, Charlottesville, Virginia... Company, Law Publishers, Charlottesville, Virginia: sections 9-337 et seq.; 9-338; 9-339; 9-340A; 9-340B..., Title 39, Chapter 44, ``Hazardous Waste Management'', published in 2002 by the Michie Company,...

  4. 75 FR 17309 - Idaho: Incorporation by Reference of Approved State Hazardous Waste Management Program

    Science.gov (United States)

    2010-04-06

    ... Management'', published in 2002 by the Michie Company, Law Publishers: sections 39- 4404; 39-4405 (except 39... Michie Company, Law Publishers: sections 39-5804; 39-5809; 39-5810; 39-5813(2); 39-5814; 39-5816; 39..., Title 9, Chapter 3, ``Public Writings'', published in 1990 by the Michie Company, Law...

  5. 77 FR 29231 - Oklahoma: Incorporation by Reference of Approved State Hazardous Waste Management Program

    Science.gov (United States)

    2012-05-17

    ... relations, Penalties, Reporting and recordkeeping requirements, Water pollution control, Water supply..., 1445 Ross Avenue, Dallas, Texas 75202-2733. 4. Hand Delivery or Courier: Deliver your comments to Alima... Planning and Permitting Division, EPA Region 6, 1445 Ross Avenue, Dallas, Texas 75202-2733....

  6. 75 FR 36546 - Oklahoma: Incorporation by Reference of Approved State Hazardous Waste Management Program

    Science.gov (United States)

    2010-06-28

    ... relations, Penalties, Reporting and recordkeeping requirements, Water pollution control, Water supply..., 1445 Ross Avenue, Dallas, Texas 75202-2733. 4. Hand Delivery or Courier: Deliver your comments to Alima... Planning and Permitting Division, EPA Region 6, 1445 Ross Avenue, Dallas, Texas 75202-2733....

  7. 77 FR 46964 - Oklahoma: Incorporation by Reference of Approved State Hazardous Waste Management Program

    Science.gov (United States)

    2012-08-07

    ... lands, Intergovernmental relations, Penalties, Reporting and recordkeeping requirements, Water pollution... Planning and Permitting Division, EPA Region 6, 1445 Ross Avenue, Dallas, Texas 75202-2733. 4. Hand... Ross Avenue, Dallas, Texas 75202-2733. Instructions: Direct your comments to Docket ID No....

  8. 19 CFR 178.2 - Listing of OMB control numbers.

    Science.gov (United States)

    2010-04-01

    ... cultural property 1515-0147 § 12.121 Approval of blanket certification under the Toxic Substances Control... control numbers. 19 CFR Section Description OMB control No. § 4.7a Unique bill of lading identifier for... declaration) 1651-0001 Editorial Note: For Federal Register citations affecting § 178.2, see the List of...

  9. Possible number systems.

    Science.gov (United States)

    Rips, Lance J; Thompson, Samantha

    2014-03-01

    Number systems-such as the natural numbers, integers, rationals, reals, or complex numbers-play a foundational role in mathematics, but these systems can present difficulties for students. In the studies reported here, we probed the boundaries of people's concept of a number system by asking them whether "number lines" of varying shapes qualify as possible number systems. In Experiment 1, participants rated each of a set of number lines as a possible number system, where the number lines differed in their structures (a single straight line, a step-shaped line, a double line, or two branching structures) and in their boundedness (unbounded, bounded below, bounded above, bounded above and below, or circular). Participants also rated each of a group of mathematical properties (e.g., associativity) for its importance to number systems. Relational properties, such as associativity, predicted whether participants believed that particular forms were number systems, as did the forms' ability to support arithmetic operations, such as addition. In Experiment 2, we asked participants to produce properties that were important for number systems. Relational, operation, and use-based properties from this set again predicted ratings of whether the number lines were possible number systems. In Experiment 3, we found similar results when the number lines indicated the positions of the individual numbers. The results suggest that people believe that number systems should be well-behaved with respect to basic arithmetic operations, and that they reject systems for which these operations produce ambiguous answers. People care much less about whether the systems have particular numbers (e.g., 0) or sets of numbers (e.g., the positives).

  10. 75 FR 42117 - Information Collection Sent to the Office of Management and Budget (OMB) for Approval; OMB...

    Science.gov (United States)

    2010-07-20

    ... Approval; OMB Control Number 1018-0144; Wildlife Without Borders--Amphibians in Decline Grant Program...-0144. Title: Wildlife Without Borders--Amphibians in Decline Grant Program. Service Form Number(s): 3... Decline grant program to fund projects that conserve the world's rapidly declining amphibian species....

  11. 76 FR 70749 - Information Collection Request Sent to the Office of Management and Budget (OMB) for Approval...

    Science.gov (United States)

    2011-11-15

    ... (OMB) for Approval; Migratory Birds and Wetlands Conservation Grant Programs AGENCY: Fish and Wildlife... Number: 1018-0100. Title: Migratory Birds and Wetlands Conservation Grant Programs. Service Form Number(s.... Standard Grants--Applications 77 77 215 16,555 NAWCA Canadian and Mexican Standard 32 32 80 2,560...

  12. Approved but non-funded vaccines: accessing individual protection.

    Science.gov (United States)

    Scheifele, David W; Ward, Brian J; Halperin, Scott A; McNeil, Shelly A; Crowcroft, Natasha S; Bjornson, Gordean

    2014-02-07

    Funded immunization programs are best able to achieve high participation rates, optimal protection of the target population, and indirect protection of others. However, in many countries public funding of approved vaccines can be substantially delayed, limited to a portion of the at-risk population or denied altogether. In these situations, unfunded vaccines are often inaccessible to individuals at risk, allowing potentially avoidable morbidity and mortality to continue to occur. We contend that private access to approved but unfunded vaccines should be reconsidered and encouraged, with recognition that individuals have a prerogative to take advantage of a vaccine of potential benefit to them whether it is publicly funded or not. Moreover, numbers of "approved but unfunded" vaccines are likely to grow because governments will not be able to fund all future vaccines of potential benefit to some citizens. New strategies are needed to better use unfunded vaccines even though the net benefits will fall short of those of funded programs. Canada, after recent delays funding several new vaccine programs, has developed means to encourage private vaccine use. Physicians are required to inform relevant patients about risks and benefits of all recommended vaccines, publicly funded or not. Likewise, some provincial public health departments now recommend and promote both funded and unfunded vaccines. Pharmacists are key players in making unfunded vaccines locally available. Professional organizations are contributing to public and provider education about unfunded vaccines (e.g. herpes zoster, not funded in any province). Vaccine companies are gaining expertise with direct-to-consumer advertising. However, major challenges remain, such as making unfunded vaccines more available to low-income families and overcoming public expectations that all vaccines will be provided cost-free, when many other recommended personal preventive measures are user-pay. The greatest need is to

  13. Algebraic number theory

    CERN Document Server

    Jarvis, Frazer

    2014-01-01

    The technical difficulties of algebraic number theory often make this subject appear difficult to beginners. This undergraduate textbook provides a welcome solution to these problems as it provides an approachable and thorough introduction to the topic. Algebraic Number Theory takes the reader from unique factorisation in the integers through to the modern-day number field sieve. The first few chapters consider the importance of arithmetic in fields larger than the rational numbers. Whilst some results generalise well, the unique factorisation of the integers in these more general number fields often fail. Algebraic number theory aims to overcome this problem. Most examples are taken from quadratic fields, for which calculations are easy to perform. The middle section considers more general theory and results for number fields, and the book concludes with some topics which are more likely to be suitable for advanced students, namely, the analytic class number formula and the number field sieve. This is the fi...

  14. All square chiliagonal numbers

    Science.gov (United States)

    Aṣiru, Muniru A.

    2016-10-01

    A square chiliagonal number is a number which is simultaneously a chiliagonal number and a perfect square (just as the well-known square triangular number is both triangular and square). In this work, we determine which of the chiliagonal numbers are perfect squares and provide the indices of the corresponding chiliagonal numbers and square numbers. The study revealed that the determination of square chiliagonal numbers naturally leads to a generalized Pell equation x2 - Dy2 = N with D = 1996 and N = 9962, and has six fundamental solutions out of which only three yielded integer values for use as indices of chiliagonal numbers. The crossing/independent recurrence relations satisfied by each class of indices of the corresponding chiliagonal numbers and square numbers are obtained. Finally, the generating functions serve as a clothesline to hang up the indices of the corresponding chiliagonal numbers and square numbers for easy display and this was used to obtain the first few sequence of square chiliagonal numbers.

  15. Preliminary reference Earth model

    Science.gov (United States)

    Dziewonski, Adam M.; Anderson, Don L.

    1981-06-01

    A large data set consisting of about 1000 normal mode periods, 500 summary travel time observations, 100 normal mode Q values, mass and moment of inertia have been inverted to obtain the radial distribution of elastic properties, Q values and density in the Earth's interior. The data set was supplemented with a special study of 12 years of ISC phase data which yielded an additional 1.75 × 10 6 travel time observations for P and S waves. In order to obtain satisfactory agreement with the entire data set we were required to take into account anelastic dispersion. The introduction of transverse isotropy into the outer 220 km of the mantle was required in order to satisfy the shorter period fundamental toroidal and spheroidal modes. This anisotropy also improved the fit of the larger data set. The horizontal and vertical velocities in the upper mantle differ by 2-4%, both for P and S waves. The mantle below 220 km is not required to be anisotropic. Mantle Rayleigh waves are surprisingly sensitive to compressional velocity in the upper mantle. High S n velocities, low P n velocities and a pronounced low-velocity zone are features of most global inversion models that are suppressed when anisotropy is allowed for in the inversion. The Preliminary Reference Earth Model, PREM, and auxiliary tables showing fits to the data are presented.

  16. Sensor Characteristics Reference Guide

    Energy Technology Data Exchange (ETDEWEB)

    Cree, Johnathan V.; Dansu, A.; Fuhr, P.; Lanzisera, Steven M.; McIntyre, T.; Muehleisen, Ralph T.; Starke, M.; Banerjee, Pranab; Kuruganti, T.; Castello, C.

    2013-04-01

    The Buildings Technologies Office (BTO), within the U.S. Department of Energy (DOE), Office of Energy Efficiency and Renewable Energy (EERE), is initiating a new program in Sensor and Controls. The vision of this program is: • Buildings operating automatically and continuously at peak energy efficiency over their lifetimes and interoperating effectively with the electric power grid. • Buildings that are self-configuring, self-commissioning, self-learning, self-diagnosing, self-healing, and self-transacting to enable continuous peak performance. • Lower overall building operating costs and higher asset valuation. The overarching goal is to capture 30% energy savings by enhanced management of energy consuming assets and systems through development of cost-effective sensors and controls. One step in achieving this vision is the publication of this Sensor Characteristics Reference Guide. The purpose of the guide is to inform building owners and operators of the current status, capabilities, and limitations of sensor technologies. It is hoped that this guide will aid in the design and procurement process and result in successful implementation of building sensor and control systems. DOE will also use this guide to identify research priorities, develop future specifications for potential market adoption, and provide market clarity through unbiased information

  17. Understanding the biosimilar approval and extrapolation process-A case study of an epoetin biosimilar.

    Science.gov (United States)

    Agarwal, Amit B; McBride, Ali

    2016-08-01

    The World Health Organization defines a biosimilar as "a biotherapeutic product which is similar in terms of quality, safety and efficacy to an already licensed reference biotherapeutic product." Biosimilars are biologic medical products that are very distinct from small-molecule generics, as their active substance is a biological agent derived from a living organism. Approval processes are highly regulated, with guidance issued by the European Medicines Agency and US Food and Drug Administration. Approval requires a comparability exercise consisting of extensive analytical and preclinical in vitro and in vivo studies, and confirmatory clinical studies. Extrapolation of biosimilars from their original indication to another is a feasible but highly stringent process reliant on rigorous scientific justification. This review focuses on the processes involved in gaining biosimilar approval and extrapolation and details the comparability exercise undertaken in the European Union between originator erythropoietin-stimulating agent, Eprex(®), and biosimilar, Retacrit™.

  18. Global Reference Tables Services Architecture

    Data.gov (United States)

    Social Security Administration — This database stores the reference and transactional data used to provide a data-driven service access method to certain Global Reference Table (GRT) service tables.

  19. Odd Multiperfect Numbers

    CERN Document Server

    Chen, Shi-Chao

    2011-01-01

    A natural number $n$ is called {\\it multiperfect} or {\\it$k$-perfect} for integer $k\\ge2$ if $\\sigma(n)=kn$, where $\\sigma(n)$ is the sum of the positive divisors of $n$. In this paper, we establish the structure theorem of odd multiperfect numbers analogous as Euler's theorem on odd perfect numbers. We prove the divisibility of the Euler part of odd multiperfect numbers and characterize the forms of odd perfect numbers $n=\\pi^\\alpha M^2$ such that $\\pi\\equiv\\alpha(\\text{mod}8)$. We also present some examples to show the nonexistence of odd perfect numbers as applications.

  20. Safety-in-numbers

    DEFF Research Database (Denmark)

    Elvik, Rune; Bjørnskau, Torkel

    2017-01-01

    Highlights •26 studies of the safety-in-numbers effect are reviewed. •The existence of a safety-in-numbers effect is confirmed. •Results are consistent. •Causes of the safety-in-numbers effect are incompletely known.......Highlights •26 studies of the safety-in-numbers effect are reviewed. •The existence of a safety-in-numbers effect is confirmed. •Results are consistent. •Causes of the safety-in-numbers effect are incompletely known....

  1. The Complexity of Manipulating $k$-Approval Elections

    CERN Document Server

    Lin, Andrew

    2010-01-01

    An important problem in computational social choice theory is the computability and complexity of undesirable behavior among agents, such as control, manipulation, and bribery in election systems. These kind of voting strategies are often tempting at the individual level but disasterous for the agents as a whole. Creating election systems where the determination of such strategies is difficult is thus an important goal. Previous work in this area has demonstrated the complexity of misuse in cases involving a fixed number of candidates, and of specific election systems on unbounded number of candidates such as Borda. In contrast, we take the first step in generalizing the results of computational complexity of election misuse to cases of infinitely many systems on an unbounded number of candidates. Interesting families of systems include $k$-approval and $k$-veto elections, in which voters distinguish $k$ candidates from the candidate set. We also demonstrate a surprising connection between manipulation in ele...

  2. Drugs Approved for Colon and Rectal Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for use in colon cancer and rectal cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

  3. Drugs Approved for Gestational Trophoblastic Disease

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for gestational trophoblastic disease. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  4. Drugs Approved for Head and Neck Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for head and neck cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  5. FDA Approves First Immunotherapy for Lymphoma

    Science.gov (United States)

    The FDA has approved nivolumab (Opdivo®) for the treatment of patients with classical Hodgkin lymphoma whose disease has relapsed or worsened after receiving an autologous hematopoietic stem cell transplantation followed by brentuximab vedotin (Adcetris®)

  6. Depression: FDA-Approved Medications May Help

    Science.gov (United States)

    ... Products For Consumers Home For Consumers Consumer Updates Depression: FDA-Approved Medications May Help Share Tweet Linkedin ... symptoms in some people. back to top Diagnosing Depression Diagnosis—which should be from a health care ...

  7. Drugs Approved for Kidney (Renal Cell) Cancer

    Science.gov (United States)

    ... 2015 2014 2013 2012 Media Resources Media Contacts Multicultural Media ... This page lists cancer drugs approved by the Food and Drug Administration (FDA) for kidney (renal cell) cancer. The list ...

  8. Drugs Approved for Soft Tissue Sarcoma

    Science.gov (United States)

    ... 2015 2014 2013 2012 Media Resources Media Contacts Multicultural Media ... This page lists cancer drugs approved by the Food and Drug Administration (FDA) for soft tissue sarcoma. The list includes ...

  9. Drugs Approved for Non-Hodgkin Lymphoma

    Science.gov (United States)

    ... 2015 2014 2013 2012 Media Resources Media Contacts Multicultural Media ... This page lists cancer drugs approved by the Food and Drug Administration (FDA) for non-Hodgkin lymphoma. The list includes ...

  10. The dilemma of approving antidotes.

    Science.gov (United States)

    Steffen, Christian

    2007-04-20

    Clinical trials with antidotes are difficult to perform for a variety of practical, ethical, and financial reasons. As acute poisoning is a rare event, the commercial interest in basic and clinical research is low. Poisoned patients are usually not available for normal clinical trial procedures and, if they are, they cannot give informed consent. This situation results in a dilemma: antidotes are essential drugs. A resolution of the Council of Europe requests to guarantee the optimal availability of antidotes and the improvement of their use. As comprehensive data on the efficacy of antidotes are often missing, a marketing authorisation under exceptional circumstances according to Article 14(8) of Regulation (EC) No. 276/2004, will often be the only way to get an approval, as: (1) the indications for which the product in question is intended are encountered so rarely that the applicant cannot reasonably be expected to provide comprehensive evidence ("orphan drug"), (2) in the present state of scientific knowledge, comprehensive information cannot be provided, or (3) it would be contrary to generally accepted principles of medical ethics to collect such data. Typically, data on antidotes are obtained from a patchwork of studies with animals, human tissue and a few observations from human poisoning corroborated with data from clinical observations and biochemistry. Generalisations from chemical and mechanistic similarities between groups of poisons are usual, but often lack scientific evidence. Current standards of good clinical practice can rarely be observed. Therefore, public funding and other financial support are necessary incentives to initiate trials in this important area.

  11. Fundamentals of Managing Reference Collections

    Science.gov (United States)

    Singer, Carol A.

    2012-01-01

    Whether a library's reference collection is large or small, it needs constant attention. Singer's book offers information and insight on best practices for reference collection management, no matter the size, and shows why managing without a plan is a recipe for clutter and confusion. In this very practical guide, reference librarians will learn:…

  12. Comparison of select reference management tools.

    Science.gov (United States)

    Zhang, Yingting

    2012-01-01

    Bibliographic management tools have been widely used by researchers to store, organize, and manage their references for research papers, theses, dissertations, journal articles, and other publications. There are a number of reference management tools available. In order for users to decide which tool is best for their needs, it is important to know each tool's strengths and weaknesses. This article compares four reference management tools, one of which is licensed by University of Medicine and Dentistry of New Jersey libraries and the other three are open source and freely available. They were chosen based on their functionality, ease of use, availability to library users, and popularity. These four tools are EndNote/EndNote Web, Zotero, Connotea, and Mendeley Desktop/Mendeley Web. Each tool is analyzed in terms of the following features: accessing, collecting, organizing, collaborating, and citing/formatting. A comparison table is included to summarize the key features of these tools.

  13. Discovery: Prime Numbers

    Science.gov (United States)

    de Mestre, Neville

    2008-01-01

    Prime numbers are important as the building blocks for the set of all natural numbers, because prime factorisation is an important and useful property of all natural numbers. Students can discover them by using the method known as the Sieve of Eratosthenes, named after the Greek geographer and astronomer who lived from c. 276-194 BC. Eratosthenes…

  14. Analytic number theory

    CERN Document Server

    Matsumoto, Kohji

    2002-01-01

    The book includes several survey articles on prime numbers, divisor problems, and Diophantine equations, as well as research papers on various aspects of analytic number theory such as additive problems, Diophantine approximations and the theory of zeta and L-function Audience Researchers and graduate students interested in recent development of number theory

  15. Estimating Large Numbers

    Science.gov (United States)

    Landy, David; Silbert, Noah; Goldin, Aleah

    2013-01-01

    Despite their importance in public discourse, numbers in the range of 1 million to 1 trillion are notoriously difficult to understand. We examine magnitude estimation by adult Americans when placing large numbers on a number line and when qualitatively evaluating descriptions of imaginary geopolitical scenarios. Prior theoretical conceptions…

  16. 76 FR 27606 - Technical Corrections To Remove Obsolete References to Non-Automated Carriers From Electronic...

    Science.gov (United States)

    2011-05-12

    ... amends the U.S. Customs and Border Protection (CBP) regulations concerning the ] mandatory electronic... in the first sentence the words ``Customs Form 1302 or a Customs-approved electronic equivalent'' and... SECURITY Customs and Border Protection 19 CFR Part 4 Technical Corrections To Remove Obsolete References...

  17. Long-term safety and efficacy of biosimilar infliximab among patients with inflammatory arthritis switched from reference product

    Directory of Open Access Journals (Sweden)

    Abdalla A

    2017-03-01

    Full Text Available Abuelmagd Abdalla, Niamh Byrne, Richard Conway, Thomas Walsh, Geraldine Mannion, Michael Hanly, Miriam O’Sullivan, Ann Maria Curran, John J Carey Department of Rheumatology, Galway University Hospitals, Galway, Ireland Purpose: To evaluate the efficacy and safety of the biosimilar infliximab in adult patients with inflammatory arthritis switched from reference product in our center. Patients and methods: In April 2014, patients attending our rheumatology service for infliximab infusions were switched from reference product to the biosimilar infliximab following consent and hospital approval. Results: Around 34 patients with inflammatory arthritis were switched from reference product to biosimilar infliximab in 2014: 50% female, mean age 55 years (standard deviation=12.9, mean disease duration 14.79 years (9.7, median duration on infliximab 57 months, and two-thirds on oral disease-modifying antirheumatic drugs. There was no difference in efficacy or safety in the first 6 months of therapy. By the end of 2015, the mean follow-up on biosimilar infliximab was 15.8 (standard deviation=6.3 months. Our results showed no significant difference in Health Assessment Questionnaire score, patient global assessment of disease activity, number of disease flares, or the medication dose between the originator and the biosimilar infliximab. However, reported pain and C-reactive protein values were significantly higher during the longer follow-up period (p=0.043, 0.001 respectively. There was no significant difference in the number of adverse events or infusion reactions during follow-up periods. Only five (14.7% patients discontinued the biosimilar infliximab. Conclusion: Our patients experienced similar efficacy and safety for managing their arthritis with the biosimilar infliximab as the reference product infliximab, but at a much lower cost. Keywords: biologic therapy, rheumatic diseases, biosimilar exchange, infliximab, adult

  18. Reference analysis of the signal + background model in counting experiments II. Approximate reference prior

    Science.gov (United States)

    Casadei, D.

    2014-10-01

    The objective Bayesian treatment of a model representing two independent Poisson processes, labelled as ``signal'' and ``background'' and both contributing additively to the total number of counted events, is considered. It is shown that the reference prior for the parameter of interest (the signal intensity) can be well approximated by the widely (ab)used flat prior only when the expected background is very high. On the other hand, a very simple approximation (the limiting form of the reference prior for perfect prior background knowledge) can be safely used over a large portion of the background parameters space. The resulting approximate reference posterior is a Gamma density whose parameters are related to the observed counts. This limiting form is simpler than the result obtained with a flat prior, with the additional advantage of representing a much closer approximation to the reference posterior in all cases. Hence such limiting prior should be considered a better default or conventional prior than the uniform prior. On the computing side, it is shown that a 2-parameter fitting function is able to reproduce extremely well the reference prior for any background prior. Thus, it can be useful in applications requiring the evaluation of the reference prior for a very large number of times.

  19. Co-reference and reasoning.

    Science.gov (United States)

    Walsh, Clare R; Johnson-Laird, P N

    2004-01-01

    Co-reference occurs when two or more noun phrases refer to the same individual, as in the following inferential problem: Mark is kneeling by the fire or he is looking at the TV but not both. / Mark is kneeling by the fire. / Is he looking at the TV? In three experiments, we compared co-referential reasoning problems with problems referring to different individuals. Experiment 1 showed that co-reference improves accuracy. In Experiment 2, we replicated that finding and showed that co-reference speeds up both reading and inference. Experiment 3 showed that the effects of co-reference are greatest when the premises and the conclusion share co-referents. These effects led the participants to make illusory inferences--that is, to draw systematically invalid conclusions. The results are discussed in terms of the mental model theory of reasoning.

  20. 36 CFR 28.15 - Approval of local zoning ordinances.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Approval of local zoning... INTERIOR FIRE ISLAND NATIONAL SEASHORE: ZONING STANDARDS Federal Standards and Approval of Local Ordinances § 28.15 Approval of local zoning ordinances. (a) The Secretary shall approve local ordinances...

  1. 30 CFR 35.9 - Certificates of approval.

    Science.gov (United States)

    2010-07-01

    ... APPROVAL OF MINING PRODUCTS FIRE-RESISTANT HYDRAULIC FLUIDS General Provisions § 35.9 Certificates of approval. (a) Upon completion of an investigation of a hydraulic fluid MSHA will issue to the applicant... notification of approval will be issued. If a certificate of approval is issued, no test data or...

  2. Applied number theory

    CERN Document Server

    Niederreiter, Harald

    2015-01-01

    This textbook effectively builds a bridge from basic number theory to recent advances in applied number theory. It presents the first unified account of the four major areas of application where number theory plays a fundamental role, namely cryptography, coding theory, quasi-Monte Carlo methods, and pseudorandom number generation, allowing the authors to delineate the manifold links and interrelations between these areas.  Number theory, which Carl-Friedrich Gauss famously dubbed the queen of mathematics, has always been considered a very beautiful field of mathematics, producing lovely results and elegant proofs. While only very few real-life applications were known in the past, today number theory can be found in everyday life: in supermarket bar code scanners, in our cars’ GPS systems, in online banking, etc.  Starting with a brief introductory course on number theory in Chapter 1, which makes the book more accessible for undergraduates, the authors describe the four main application areas in Chapters...

  3. Death of Reference or Birth of a New Marketing Age?

    Science.gov (United States)

    Henry, Jo

    2011-01-01

    Reference transactions in academic libraries have been on the decline since mid-1990. The Academic Library Survey from the National Center for Education Statistics shows an average drop of 25% in reference use from 1996-2004 with higher numbers at some institutions such as the University of Maryland which plummeted 47% (Martell, 2008). The…

  4. Staffing by Design: A Methodology for Staffing Reference

    Science.gov (United States)

    Ward, David; Phetteplace, Eric

    2012-01-01

    The growth in number and kind of online reference services has resulted in both new users consulting library research services as well as new patterns of service use. Staffing in-person and virtual reference services desks adequately requires a systematic analysis of patterns of use across service points in order to successfully meet fluctuating…

  5. Africa South of the Sahara: A Guide to Reference Sources.

    Science.gov (United States)

    Mason, Mary, Comp.

    This annotated bibliography has been compiled as an introduction to reference resources for college-level African studies and to suggest useful tools for literature searches. It is a guide to materials in the library of McGill University. Call numbers are included. The titles cited refer to Africa South of the Sahara as a whole or to large…

  6. Virtual Reference Interferometry: Theory & Experiment

    Science.gov (United States)

    Galle, Michael Anthony

    This thesis introduces the idea that a simulated interferogram can be used as a reference for an interferometer. This new concept represents a paradigm shift from the conventional thinking, where a reference is the phase of a wavefront that traverses a known path. The simulated interferogram used as a reference is called a virtual reference. This thesis develops the theory of virtual reference interferometry and uses it for the characterization of chromatic dispersion in short length (virtual reference combines the advantages of these techniques so that it is both accurate and easy to operate. Chromatic dispersion measurements based on virtual reference interferometry have similar accuracy as the best conventional measurement techniques due to the ability to measure first and second order dispersion directly from the interference pattern. Unique capabilities of virtual reference interferometry are demonstrated, followed by a derivation of the operational constraints and system parameters. The technique is also applied to the characterization of few-mode fibers, a hot topic in telecommunications research where mode division multiplexing promises to expand network bandwidth. Also introduced is the theory of dispersive virtual reference interferometry, which can be used to overcome the bandwidth limitations associated with the measurement of near-zero dispersion-length optical components via compression of the interference pattern. Additionally, a method for utilizing the virtual reference interferometer in a low-coherence setup is introduced, enabling characterization in new wavelength ranges and further reducing the cost of characterization.

  7. Reference Design of the Mu2e Detector Solenoid

    CERN Document Server

    Feher, S; Brandt,, J; Cheban, S; Coleman, R; Dhanaraj, N; Fang, I; Lamm, M; Lombardo, V; Lopes, M; Miller, J; Ostojic, R ,; Orris, D; Page, T; Peterson, T; Tang, Z; Wands, R

    2014-01-01

    The Mu2e experiment at Fermilab has been approved by the Department of Energy to proceed developing the preliminary design. Integral to the success of Mu2e is the superconducting solenoid system. One of the three major solenoids is the Detector Solenoid that houses the stopping target and the detectors. The goal of the Detector Solenoid team is to produce detailed design specifications that are sufficient for vendors to produce the final design drawings, tooling and fabrication procedures and proceed to production. In this paper we summarize the Reference Design of the Detector Solenoid.

  8. Natural rates of teacher approval and disapproval in the classroom.

    Science.gov (United States)

    White, M A

    1975-01-01

    Sixteen classroom observational studies were conducted to determine natural rates of teacher verbal approval and disapproval in the classroom. Rates of teacher verbal approval and disapproval were measured by the Teacher Approval and Disapproval Observation Record (TAD) over Grades 1 through 12. Teacher verbal approval rates dropped over grade, with a marked drop after second grade. In every grade after second, the rate of teacher verbal disapproval exceeded the rate of teacher verbal approval. These rates are interpreted in terms of reinforcement theory.

  9. Predicting Lotto Numbers

    DEFF Research Database (Denmark)

    Jørgensen, Claus Bjørn; Suetens, Sigrid; Tyran, Jean-Robert

    numbers based on recent drawings. While most players pick the same set of numbers week after week without regards of numbers drawn or anything else, we find that those who do change, act on average in the way predicted by the law of small numbers as formalized in recent behavioral theory. In particular......We investigate the “law of small numbers” using a unique panel data set on lotto gambling. Because we can track individual players over time, we can measure how they react to outcomes of recent lotto drawings. We can therefore test whether they behave as if they believe they can predict lotto......, on average they move away from numbers that have recently been drawn, as suggested by the “gambler’s fallacy”, and move toward numbers that are on streak, i.e. have been drawn several weeks in a row, consistent with the “hot hand fallacy”....

  10. Predicting Lotto Numbers

    DEFF Research Database (Denmark)

    Jørgensen, Claus Bjørn; Suetens, Sigrid; Tyran, Jean-Robert

    We investigate the “law of small numbers” using a unique panel data set on lotto gambling. Because we can track individual players over time, we can measure how they react to outcomes of recent lotto drawings. We can therefore test whether they behave as if they believe they can predict lotto...... numbers based on recent drawings. While most players pick the same set of numbers week after week without regards of numbers drawn or anything else, we find that those who do change, act on average in the way predicted by the law of small numbers as formalized in recent behavioral theory. In particular......, on average they move away from numbers that have recently been drawn, as suggested by the “gambler’s fallacy”, and move toward numbers that are on streak, i.e. have been drawn several weeks in a row, consistent with the “hot hand fallacy”....

  11. The Relationship between Children's Familiarity with Numbers and Their Performance in Bounded and Unbounded Number Line Estimations

    Science.gov (United States)

    Ebersbach, Mirjam; Luwel, Koen; Verschaffel, Lieven

    2015-01-01

    Children's estimation skills on a bounded and unbounded number line task were assessed in the light of their familiarity with numbers. Kindergartners, first graders, and second graders (N = 120) estimated the position of numbers on a 1--100 number line, marked with either two reference points (i.e., 1 and 10: unbounded condition) or three…

  12. Fibonacci and Lucas numbers with applications

    CERN Document Server

    Koshy, Thomas

    2011-01-01

    [Koshy's] book is without doubt the most comprehensive and scholarly work on Fibonacci numbers to date and I am sure that it will quickly signal its presence and impose itself as an authoritative reference manual on Fibonacci numbers. -Napoleon Gauthier, Royal Military College of Canada, Kingston, ON What a gem this is! [...] My only regrest about the book is that it wasn't around years ago. It fills such a void. -Monte Zerger, Adams State College, Alamosa, CO

  13. Music By Numbers

    CERN Document Server

    Cocos, Mihail

    2011-01-01

    In this paper we present a mathematical way of defining musical modes, we derive a formula for the total number of modes and define the musicality of a mode as the total number of harmonic chords whithin the mode. We also give an algorithm for the construction of a duet of melodic lines given a sequence of numbers and a mode. We attach the .mus files of the counterpoints obtained by using the sequence of primes and several musical modes.

  14. Quantum Random Number Generators

    OpenAIRE

    Herrero-Collantes, Miguel; Garcia-Escartin, Juan Carlos

    2016-01-01

    Random numbers are a fundamental resource in science and engineering with important applications in simulation and cryptography. The inherent randomness at the core of quantum mechanics makes quantum systems a perfect source of entropy. Quantum random number generation is one of the most mature quantum technologies with many alternative generation methods. We discuss the different technologies in quantum random number generation from the early devices based on radioactive decay to the multipl...

  15. 78 FR 58268 - Notice of Request for Approval of an Information Collection; National Animal Health Monitoring...

    Science.gov (United States)

    2013-09-23

    ...; National Animal Health Monitoring System; Cervid 2014 Study AGENCY: Animal and Plant Health Inspection... intention to request approval of a new information collection for the National Animal Health Monitoring...: National Animal Health Monitoring System; Cervid 2014 Study. OMB Number: 0579-XXXX. Type of...

  16. 78 FR 58269 - Notice of Request for Approval of an Information Collection; National Animal Health Monitoring...

    Science.gov (United States)

    2013-09-23

    ...; National Animal Health Monitoring System; Bison 2014 Study AGENCY: Animal and Plant Health Inspection... intention to request approval of a new information collection for the National Animal Health Monitoring...: National Animal Health Monitoring System; Bison 2014 Study. OMB Number: 0579-XXXX. Type of...

  17. 78 FR 21338 - Notice of Request for Extension of a Currently Approved Information Collection (Registration...

    Science.gov (United States)

    2013-04-10

    ... race, color, national origin, gender, religion, age, disability, political beliefs, sexual orientation... Portal: This Web site provides the ability to type short comments directly into the comment field on this.... Type of Request: Extension of an approved information collection. OMB Control Number:...

  18. 78 FR 40090 - Notice of Request for Revision of a Currently Approved Information Collection (Interstate...

    Science.gov (United States)

    2013-07-03

    ..., national origin, gender, religion, age, disability, political beliefs, sexual orientation, and marital or... the ability to type short comments directly into the comment field on this Web page or attach a file... Products. Type of Request: Revision of an approved information collection. OMB Control Number:...

  19. 76 FR 65164 - Notice of Request for Extension of Approval of an Information Collection; Hawaiian and...

    Science.gov (United States)

    2011-10-20

    ... Collection; Hawaiian and Territorial Quarantine Notices AGENCY: Animal and Plant Health Inspection Service... your comment to Docket No. APHIS-2011-0096, Regulatory Analysis and Development, PPD, APHIS, Station 3A... and Territorial Quarantine Notices. OMB Number: 0579-0198. Type of Request: Extension of approval...

  20. 78 FR 1266 - Notice of Intent To Seek Approval To Extend a Current Information Collection

    Science.gov (United States)

    2013-01-08

    ... Research and Development Survey. OMB Control Number: 3145-0100. ] Expiration Date of Current Approval: October 31, 2013. Proposed Renewal Project: The Higher Education Research and Development Survey (formerly... working on R&D. Data are published in NSF's annual publication series Higher Education Research......

  1. 76 FR 79754 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

    Science.gov (United States)

    2011-12-22

    ... aircraft, engines, propellers, and spare parts locations. DATES: Written comments should be submitted by... of Renewed Approval of Information Collection: Recording of Aircraft Conveyances and Security... Aircraft Conveyances and Security Documents. Form Numbers: FAA Form 8050-41. Type of Review: Renewal of...

  2. 78 FR 55237 - Notice of a Request for Extension of a Currently Approved Information Collection

    Science.gov (United States)

    2013-09-10

    ... importer, manufacturer or exporter of certain dairy products; (2) certify they meet the eligibility... and non-cheese dairy products, and exporters of non-cheese dairy products. Estimated Number of... intention to request an extension for a currently approved information collection in support of the...

  3. 78 FR 17890 - Effective Date of Requirement for Premarket Approval for Automated External Defibrillator System.

    Science.gov (United States)

    2013-03-25

    ... devices it is appropriate to regulate them in class III. Furthermore, the problems with medical device... found to be substantially equivalent to such a device, will be permitted to continue marketing such... model numbers for which a manufacturer plans to seek marketing approval through its PMA. FDA...

  4. 78 FR 76387 - Notice of Passenger Facility Charge (PFC) Approvals and Disapprovals

    Science.gov (United States)

    2013-12-17

    ...-2835. Public Agency: City of Garden City, Kansas. Application Number: 13-01-C-00-GCK. Application Type... Garden City Regional Airport. Brief Description of Projects Approved for Collection and Use: Security... lighting. Rehabilitate taxiway--phase I. Install runway vertical/visual guidance system....

  5. 76 FR 49303 - Approval and Promulgation of Air Quality Implementation Plans; Minnesota; Rules Update

    Science.gov (United States)

    2011-08-10

    ...)--Continuous Emission Monitoring Systems (CEMS) and Continuous Opacity Monitoring Systems (COMS). Prior to the.... The current SIP approved CEMS rule, Minn. R. 7017.1000, was repealed and replaced with more detailed... document begins]. 7017.1140 CEMS design 03/01/99 08/10/11, [Insert page requirements. number where...

  6. 75 FR 67388 - Credit Watch Termination Initiative; Termination of Direct Endorsement (DE) Approval

    Science.gov (United States)

    2010-11-02

    ...-8000; telephone (202) 708-2830 (this is not a toll-free number). Persons with hearing or speech... published a notice (64 FR 26769), on its procedures for terminating Origination Approval Agreements with FHA... Freedom Mortgage Corp......... 907 Pleasant Valley Fort Worth....... 10/4/10 Denver. Ave. Mount Laurel,...

  7. 77 FR 5262 - Credit Watch Termination Initiative Termination of Direct Endorsement (DE) Approval

    Science.gov (United States)

    2012-02-02

    ...-8000; telephone (202) 708-2830 (this is not a toll-free number). Persons with hearing or speech... were approved before the Termination became effective may be submitted for insurance endorsement... jurisdiction effective date Homeownership center Mortgage Source LLC 600 Old Country New York...

  8. 75 FR 10013 - Agency Information Collection Activities: Request for Comments; Renewed Approval of Information...

    Science.gov (United States)

    2010-03-04

    ... in a right-of-way procedural (operations) manual the organization, policies and procedures of the...-date right-of-way procedural manual is set out in 23 CFR 710.201(c). The regulation allows States... Approval of Information Collection; State Right-of-Way Operations Manuals, OMB Control Number:...

  9. 76 FR 31674 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

    Science.gov (United States)

    2011-06-01

    ... of Renewed Approval of Information Collection; SWIFT Customer Satisfaction Survey AGENCY: Federal... determine how satisfied applicants are with the automated staffing solution. The information enables the FAA....Scott@faa.gov . SUPPLEMENTARY INFORMATION: OMB Control Number: 2120-0699. Title: SWIFT...

  10. 75 FR 29306 - Notice of Request for Extension of a Currently Approved Information Collection

    Science.gov (United States)

    2010-05-25

    ..., in a manner which protects the confidentiality of the reporting entity. AMS is in the best position..., swine, lamb, and boxed beef market news reports under the Livestock Mandatory Reporting Act of 1999...: Livestock Mandatory Reporting Act of 1999. OMB Number: 0581-0186. Expiration Date of Approval:...

  11. 50 CFR 403.03 - Review and approval of State request for management authority.

    Science.gov (United States)

    2010-10-01

    ... toward OSP; (iv) Do not permit take that is for scientific research or public display purposes except... management authority will not be approved unless it contains the following: (1) The scientific and common... maximum number of animals that may be taken without reducing the species below its OSP, and, in the...

  12. Predicting Lotto Numbers

    DEFF Research Database (Denmark)

    Suetens, Sigrid; Galbo-Jørgensen, Claus B.; Tyran, Jean-Robert Karl

    2016-01-01

    as formalized in recent behavioral theory. In particular, players tend to bet less on numbers that have been drawn in the preceding week, as suggested by the ‘gambler’s fallacy’, and bet more on a number if it was frequently drawn in the recent past, consistent with the ‘hot-hand fallacy’.......We investigate the ‘law of small numbers’ using a data set on lotto gambling that allows us to measure players’ reactions to draws. While most players pick the same set of numbers week after week, we find that those who do change react on average as predicted by the law of small numbers...

  13. Numbers, sequences and series

    CERN Document Server

    Hirst, Keith

    1994-01-01

    Number and geometry are the foundations upon which mathematics has been built over some 3000 years. This book is concerned with the logical foundations of number systems from integers to complex numbers. The author has chosen to develop the ideas by illustrating the techniques used throughout mathematics rather than using a self-contained logical treatise. The idea of proof has been emphasised, as has the illustration of concepts from a graphical, numerical and algebraic point of view. Having laid the foundations of the number system, the author has then turned to the analysis of infinite proc

  14. The adventure of numbers

    CERN Document Server

    Godefroy, Gilles

    2004-01-01

    Numbers are fascinating. The fascination begins in childhood, when we first learn to count. It continues as we learn arithmetic, algebra, geometry, and so on. Eventually, we learn that numbers not only help us to measure the world, but also to understand it and, to some extent, to control it. In The Adventure of Numbers, Gilles Godefroy follows the thread of our expanding understanding of numbers to lead us through the history of mathematics. His goal is to share the joy of discovering and understanding this great adventure of the mind. The development of mathematics has been punctuated by a n

  15. 78 FR 21547 - Approval and Promulgation of Air Quality Implementation Plans; Oregon: Eugene-Springfield PM10

    Science.gov (United States)

    2013-04-11

    ... approving the LMP in accordance with the principles outlined in the LMP Option memo. Upon the effective date..., the LMP references the Oregon ``Heat Smart'' law. This law has been adopted state-wide and requires... National Technology Transfer and Advancement Act of 1995 (15 U.S.C. 272 note) because application of...

  16. 78 FR 57857 - Medicare and Medicaid Programs; Application from the Compliance Team for Initial CMS-Approval of...

    Science.gov (United States)

    2013-09-20

    ... the Compliance Team for Initial CMS-Approval of its Rural Health Clinic Accreditation Program AGENCY... below, no later than 5 p.m. on October 21, 2013. ADDRESSES: In commenting, please refer to file code CMS... Services, Attention: CMS-3287-PN, P.O. Box 8016, Baltimore, MD 21244-8010. Please allow sufficient time...

  17. Relativistic formulation and reference frame

    OpenAIRE

    Klioner, Sergei A.

    2004-01-01

    After a short review of experimental foundations of metric theories of gravity, the choice of general relativity as a theory to be used for the routine modeling of Gaia observations is justified. General principles of relativistic modeling of astronomical observations are then sketched and compared to the corresponding Newtonian principles. The fundamental reference system -- Barycentric Celestial Reference System, which has been chosen to be the relativistic reference system underlying the f...

  18. User Preferences in Reference Services: Virtual Reference and Academic Libraries

    Science.gov (United States)

    Cummings, Joel; Cummings, Lara; Frederiksen, Linda

    2007-01-01

    This study examines the use of chat in an academic library's user population and where virtual reference services might fit within the spectrum of public services offered by academic libraries. Using questionnaires, this research demonstrates that many within the academic community are open to the idea of chat-based reference or using chat for…

  19. Acute Myeloid Leukemia - Genetics Home Reference [Genetics Home Reference (Conditions)

    Lifescience Database Archive (English)

    Full Text Available Conditions Genes Chromosomes Handbook Glossary Resources Conditions > Acute Myeloid...te myeloid leukemia with mutated CEBPA Fanconi anemia You may also search Genetics Home Reference for Acut...e Myeloid Leukemia for additional information. Published : October 27, 2014 Acute Myeloid Leukemia - Genetics Home Reference ...

  20. Java for dummies quick reference

    CERN Document Server

    Lowe, Doug

    2012-01-01

    A reference that answers your questions as you move through your coding The demand for Android programming and web apps continues to grow at an unprecedented pace and Java is the preferred language for both. Java For Dummies Quick Reference keeps you moving through your coding while you solve a problem, look up a command or syntax, or search for a programming tip. Whether you're a Java newbie or a seasoned user, this fast reference offers you quick access to solutions without requiring that you wade through pages of tutorial material. Leverages the true reference format that is organized with

  1. The Fibonacci Numbers.

    Science.gov (United States)

    Onstad, Torgeir

    1991-01-01

    After a brief historical account of Leonardo Pisano Fibonacci, some basic results concerning the Fibonacci numbers are developed and proved, and entertaining examples are described. Connections are made between the Fibonacci numbers and the Golden Ratio, biological nature, and other combinatorics examples. (MDH)

  2. Multispecies quantum Hurwitz numbers

    CERN Document Server

    Harnad, J

    2014-01-01

    The construction of hypergeometric 2D Toda $\\tau$-functions as generating functions for quantum Hurwitz numbers is extended here to multispecies families. Both the enumerative geometrical significance of these multispecies quantum Hurwitz numbers as weighted enumerations of branched coverings of the Riemann sphere and their combinatorial significance in terms of weighted paths in the Cayley graph of $S_n$ are derived.

  3. Hyperquarks and generation number

    CERN Document Server

    Buchmann, Alfons J

    2013-01-01

    In a model in which quarks and leptons are built up from two spin 1/2 preons as fundamental entities, a new class of fermionic bound states (hyperquarks) arises. It turns out that these hyperquarks are necessary to fulfill the 't Hooft anomaly constraint, which then links the number of fermionic generations to the number of colors and hypercolors.

  4. On the Lyapunov numbers

    OpenAIRE

    Kolyada, Sergiy; Rybak, Oleksandr

    2013-01-01

    We introduce and study the Lyapunov numbers -- quantitative measures of the sensitivity of a dynamical system $(X,f)$ given by a compact metric space $X$ and a continuous map $f:X \\to X$. In particular, we prove that for a minimal topologically weakly mixing system all Lyapunov numbers are the same.

  5. 76 FR 68780 - Renewal of Approved Information Collection, OMB Control Number 1004-0201

    Science.gov (United States)

    2011-11-07

    ... validity of the methodology and assumptions used; 3. The quality, utility and clarity of the information to..., including the use of appropriate automated, electronic, mechanical, or other forms of information technology... lessees, and operators. This collection enables the BLM to: (1) Learn the extent and qualities of...

  6. 32 CFR Appendix B to Part 623 - Approving Authority Addresses/Telephone Numbers *

    Science.gov (United States)

    2010-07-01

    ..., WATS 415-561-4110; B-12. Commander, US Army Armament Materiel Readiness Command, ATTN: DRSAR-MMS, Rock Island, IL 61229; B-13. Commander, US Army Armament Research and Development Command, Dover, NJ 07801;...

  7. 75 FR 1647 - Extension of Approved Information Collection, OMB Control Number 1004-0001

    Science.gov (United States)

    2010-01-12

    ... requirements in 43 CFR parts 3620 and 5510, which pertain to free use of, respectively, petrified wood, timber... manage the collection of limited quantities of petrified wood and timber for noncommercial purposes....

  8. [State of Michigan Teacher Education Manual 1970, Sections I and II--Approval of Teacher Education Institutions and Approval of Teacher Education Programs at Approved Teacher Education Institutions].

    Science.gov (United States)

    Michigan State Dept. of Education, Lansing. Teacher Preparation and Professional Development Services.

    This document presents rules and regulations of the Michigan State Board of Education concerning procedures for the approval of teacher education institutions and teacher education programs. The first section details processes in institutional approval, presenting: (1) legislative authority; (2) characteristics of the Approved Program System; (3)…

  9. High Falls generation station expansion approvals process

    Energy Technology Data Exchange (ETDEWEB)

    Litschko, C. [Lakeland Holding, Bracebridge, ON (Canada)

    2005-07-01

    Lakeland Holding Ltd. is the parent company for Lakeland Power Distribution Ltd., Bracebridge Generation Ltd., and Lakeland Energy Ltd. This PowerPoint presentation highlighted the High Falls generation expansion process. During construction of the High Falls plant, a concrete foundation was built beside the plant for future expansion. The expansion process involves building a 1,500 kilowatt generator to supply electricity to as many as 1600 households. The presentation described the context and background for the expansion and presented information on the water power generation plants. It presented site specifications as well as the approvals process by which final approval was granted in 2004. Observations and lessons learned from the approval process were identified. figs.

  10. Development of a P.A.C.E.-approved continuing education program for the community hospital.

    Science.gov (United States)

    Chrest, C B; Bresnahan, J L; Dubesa, E P; Wahlgren, E A

    1978-08-01

    A Professional Acknowledgment for Continuing Education (P.A.C.E.) approved continuing education program was developed for laboratory technologists at Sherman Hospital, Elgin, Illinois, on an in-service basis. The results of a needs analysis of staff technologists provided the basis for selection of program content. The program was presented as four one-hour monthly sessions and videotaped for showing at later dates. This methodology proved extremely effective in providing a maximum number of technologists with a P.A.C.E.-approved and documented continuing education program while keeping disruption of the work schedule in the laboratory to a minimum.

  11. Numbers in Action.

    Science.gov (United States)

    Rugani, Rosa; Sartori, Luisa

    2016-01-01

    Humans show a remarkable tendency to describe and think of numbers as being placed on a mental number line (MNL), with smaller numbers located on the left and larger ones on the right. Faster responses to small numbers are indeed performed on the left side of space, while responses to large numbers are facilitated on the right side of space (spatial-numerical association of response codes, SNARC effect). This phenomenon is considered the experimental demonstration of the MNL and has been extensively replicated throughout a variety of paradigms. Nevertheless, the majority of previous literature has mainly investigated this effect by means of response times and accuracy, whereas studies considering more subtle and automatic measures such as kinematic parameters are rare (e.g., in a reaching-to-grasp movement, the grip aperture is enlarged in responding to larger numbers than in responding to small numbers). In this brief review we suggest that numerical magnitude can also affect the what and how of action execution (i.e., temporal and spatial components of movement). This evidence could have large implications in the strongly debated issue concerning the effect of experience and culture on the orientation of MNL.

  12. Development of Pain Endpoint Models for Use in Prostate Cancer Clinical Trials and Drug Approval

    Science.gov (United States)

    2015-10-01

    Award Number: W81XWH-11-1-0639 TITLE: Development of Pain Endpoint Models for Use in Prostate Cancer Clinical Trials and Drug Approval PRINCIPAL...SEP 2014 – 29 SEP 2015 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER W81XWH-11-1-0639 Development of Pain Endpoint Models for Use in Prostate Cancer...standard methods for measuring pain palliation and pain progression in prostate cancer clinical trials that are feasible, methodologically rigorous, and

  13. Dedicated online virtual reference instruction.

    Science.gov (United States)

    Guillot, Ladonna; Stahr, Beth; Plaisance, Louise

    2005-01-01

    To facilitate nursing students' information literacy skills and enhance traditional library user services, academic librarians have developed synchronous (real-time) online virtual reference instruction in nursing research classes. The authors discuss collaborative efforts of nursing and library faculty in planning, implementing, and evaluating a discipline-specific virtual reference pilot program.

  14. The Virtual Reference Librarian's Handbook.

    Science.gov (United States)

    Lipow, Anne Grodzins

    This book is a practical guide to librarians and their administrators who are thinking about or in the early stages of providing virtual reference service. Part 1, "The Decision to Go Virtual," provides a context for thinking about virtual reference, including the benefits and problems, getting in the virtual frame of mind, and shopping…

  15. Reference counting for reversible languages

    DEFF Research Database (Denmark)

    Mogensen, Torben Ægidius

    2014-01-01

    deallocation. This requires the language to be linear: A pointer can not be copied and it can only be eliminated by deallocating the node to which it points. We overcome this limitation by adding reference counts to nodes: Copying a pointer to a node increases the reference count of the node and eliminating...

  16. Technostress and the Reference Librarian.

    Science.gov (United States)

    Kupersmith, John

    1992-01-01

    Defines "technostress" as the stress experienced by reference librarians who must constantly deal with the demands of new information technology and the changes they produce in the work place. Discussion includes suggested ways in which both organizations and individuals can work to reduce stress. (27 references) (LAE)

  17. Brief history of numbers

    CERN Document Server

    Corry, Leo

    2015-01-01

    The world around us is saturated with numbers. They are a fundamental pillar of our modern society, and accepted and used with hardly a second thought. But how did this state of affairs come to be? In this book, Leo Corry tells the story behind the idea of number from the early days of the Pythagoreans, up until the turn of the twentieth century. He presents an overview of how numbers were handled and conceived in classical Greek mathematics, in the mathematics of Islam, in European mathematics of the middle ages and the Renaissance, during the scientific revolution, all the way through to the

  18. Professor Stewart's incredible numbers

    CERN Document Server

    Stewart, Ian

    2015-01-01

    Ian Stewart explores the astonishing properties of numbers from 1 to10 to zero and infinity, including one figure that, if you wrote it out, would span the universe. He looks at every kind of number you can think of - real, imaginary, rational, irrational, positive and negative - along with several you might have thought you couldn't think of. He explains the insights of the ancient mathematicians, shows how numbers have evolved through the ages, and reveals the way numerical theory enables everyday life. Under Professor Stewart's guidance you will discover the mathematics of codes,

  19. Algebraic number theory

    CERN Document Server

    Weiss, Edwin

    1998-01-01

    Careful organization and clear, detailed proofs characterize this methodical, self-contained exposition of basic results of classical algebraic number theory from a relatively modem point of view. This volume presents most of the number-theoretic prerequisites for a study of either class field theory (as formulated by Artin and Tate) or the contemporary treatment of analytical questions (as found, for example, in Tate's thesis).Although concerned exclusively with algebraic number fields, this treatment features axiomatic formulations with a considerable range of applications. Modem abstract te

  20. Generalized Erdos Numbers

    CERN Document Server

    Morrison, Greg

    2010-01-01

    We propose a simple real-valued generalization of the well known integer-valued Erdos number as a topological, non-metric measure of the `closeness' felt between two nodes in an undirected, weighted graph. These real-valued Erdos numbers are asymmetric and are able to distinguish between network topologies that standard distance metrics view as identical. We use this measure to study some simple analytically tractable networks, and show the utility of our measure to devise a ratings scheme based on the generalized Erdos number that we deploy on the data from the NetFlix prize, and find a significant improvement in our ratings prediction over a baseline.

  1. Fundamentals of number theory

    CERN Document Server

    LeVeque, William J

    1996-01-01

    This excellent textbook introduces the basics of number theory, incorporating the language of abstract algebra. A knowledge of such algebraic concepts as group, ring, field, and domain is not assumed, however; all terms are defined and examples are given - making the book self-contained in this respect.The author begins with an introductory chapter on number theory and its early history. Subsequent chapters deal with unique factorization and the GCD, quadratic residues, number-theoretic functions and the distribution of primes, sums of squares, quadratic equations and quadratic fields, diopha

  2. Elementary theory of numbers

    CERN Document Server

    Sierpinski, Waclaw

    1988-01-01

    Since the publication of the first edition of this work, considerable progress has been made in many of the questions examined. This edition has been updated and enlarged, and the bibliography has been revised.The variety of topics covered here includes divisibility, diophantine equations, prime numbers (especially Mersenne and Fermat primes), the basic arithmetic functions, congruences, the quadratic reciprocity law, expansion of real numbers into decimal fractions, decomposition of integers into sums of powers, some other problems of the additive theory of numbers and the theory of Gaussian

  3. Numbers and computers

    CERN Document Server

    Kneusel, Ronald T

    2015-01-01

    This is a book about numbers and how those numbers are represented in and operated on by computers. It is crucial that developers understand this area because the numerical operations allowed by computers, and the limitations of those operations, especially in the area of floating point math, affect virtually everything people try to do with computers. This book aims to fill this gap by exploring, in sufficient but not overwhelming detail, just what it is that computers do with numbers. Divided into two parts, the first deals with standard representations of integers and floating point numb

  4. The emergence of number

    CERN Document Server

    Crossley, John N

    1987-01-01

    This book presents detailed studies of the development of three kinds of number. In the first part the development of the natural numbers from Stone-Age times right up to the present day is examined not only from the point of view of pure history but also taking into account archaeological, anthropological and linguistic evidence. The dramatic change caused by the introduction of logical theories of number in the 19th century is also treated and this part ends with a non-technical account of the very latest developments in the area of Gödel's theorem. The second part is concerned with the deve

  5. Elementary number theory

    CERN Document Server

    Dudley, Underwood

    2008-01-01

    Ideal for a first course in number theory, this lively, engaging text requires only a familiarity with elementary algebra and the properties of real numbers. Author Underwood Dudley, who has written a series of popular mathematics books, maintains that the best way to learn mathematics is by solving problems. In keeping with this philosophy, the text includes nearly 1,000 exercises and problems-some computational and some classical, many original, and some with complete solutions. The opening chapters offer sound explanations of the basics of elementary number theory and develop the fundamenta

  6. Advanced number theory

    CERN Document Server

    Cohn, Harvey

    1980-01-01

    ""A very stimulating book ... in a class by itself."" - American Mathematical MonthlyAdvanced students, mathematicians and number theorists will welcome this stimulating treatment of advanced number theory, which approaches the complex topic of algebraic number theory from a historical standpoint, taking pains to show the reader how concepts, definitions and theories have evolved during the last two centuries. Moreover, the book abounds with numerical examples and more concrete, specific theorems than are found in most contemporary treatments of the subject.The book is divided into three parts

  7. Accuracy of references in Internet Journal of Medical Update

    Directory of Open Access Journals (Sweden)

    Prakash Adhikari

    2011-07-01

    Full Text Available This study was done to observe the accuracy of references in articles published in Internet Journal of Medical Update (IJMU. Sixty references were randomly selected from IJMU (Volume 5, Number 2, July 2010, Volume 4, Number 2, July 2009 and Volume 4, Number 1, January 2009. The instructions for authors of this journal were looked carefully. All the references were compared with the original for accuracy, using the following six elements: authors name; journal name as per Index Medicus; year; volume; and page numbers. References were considered incorrect if there was an error in any of these six elements. Statistical analysis was done by using frequency and percentage. Ten percent references in Internet Journal of Medical Update were inaccurate. Most common errors were author’s name and title of the article. Author’s names were found to be incorrect in 5.0% references while title of the article was found to be incorrect in 3.3%. Least common error was found in writing the journal name (either incorrect abbreviations or incorrect instructions or punctuation errors in (1.7%. Inaccuracies of references are also found in the Internet Journal of Medical Update. The majority of errors in IJMU are avoidable. So, the authors, editors and the reviewers have to check for any errors seriously before publication in the journal.

  8. [Errors in literature references in the Nederlands Tijdschrift voor Geneeskunde].

    Science.gov (United States)

    Hobma, S O; Overbeke, A J

    1992-03-28

    Literature references contain a considerable number of inaccuracies, both in citations and in quotations. We investigated the accuracy of quotations and references in Nederlands Tijdschrift voor Geneeskunde. We checked at random 100 references of articles presented for publication during a period of 4 weeks using Index Medicus. The citation and quotation of another 100 references (50 with a reading list of less than 13, and 50 with a reading list of more than 24 articles) of published original articles were checked, using the original article. In the references of articles presented for publication 70% contained one or more inaccuracies. In the published articles 31% was not completely correct. In 5% these errors prevented immediate identification of the cited article. In one of every three articles a citation error was made: 5 trivial errors, 16 slightly misleading and 12 seriously misleading errors were found. We could not find a relation between the number of citation errors and the length of the reading list. The original source was not cited in 8 articles. Our conclusion is that the number of inaccuracies, in references as well as in citations, is high; authors should check this part of their articles more carefully. Notably the use of multiple references after a sentence with a number of statements is to be avoided.

  9. VLSI binary multiplier using residue number systems

    Energy Technology Data Exchange (ETDEWEB)

    Barsi, F.; Di Cola, A.

    1982-01-01

    The idea of performing multiplication of n-bit binary numbers using a hardware based on residue number systems is considered. This paper develops the design of a VLSI chip deriving area and time upper bounds of a n-bit multiplier. To perform multiplication using residue arithmetic, numbers are converted from binary to residue representation and, after residue multiplication, the result is reconverted to the original notation. It is shown that the proposed design requires an area a=o(n/sup 2/ log n) and an execution time t=o(log/sup 2/n). 7 references.

  10. Interactions: A Study of Office Reference Statistics

    Directory of Open Access Journals (Sweden)

    Naomi Lederer

    2012-06-01

    Full Text Available Objective – The purpose of this study was to analyze the data from a referencestatistics-gathering mechanism at Colorado State University (CSU Libraries. It aimedprimarily to better understand patron behaviours, particularly in an academic librarywith no reference desk.Methods – The researchers examined data from 2007 to 2010 of College LiaisonLibrarians’ consultations with patrons. Data were analyzed by various criteria,including patron type, contact method, and time spent with the patron. Theinformation was examined in the aggregate, meaning all librarians combined, andthen specifically from the Liberal Arts and Business subject areas.Results – The researchers found that the number of librarian reference consultationsis substantial. Referrals to librarians from CSU’s Morgan Library’s one public servicedesk have declined over time. The researchers also found that graduate students arethe primary patrons and email is the preferred contact method overall.Conclusion – The researchers found that interactions with patrons in librarians’ offices – either in person or virtually – remain substantial even without a traditional reference desk. The data suggest that librarians’ efforts at marketing themselves to departments, colleges, and patrons have been successful. This study will be of value to reference, subject specialist, and public service librarians, and library administrators as they consider ways to quantify their work, not only for administrative purposes, but in order to follow trends and provide services and staffing accordingly.

  11. Xyce parallel electronic simulator : reference guide.

    Energy Technology Data Exchange (ETDEWEB)

    Mei, Ting; Rankin, Eric Lamont; Thornquist, Heidi K.; Santarelli, Keith R.; Fixel, Deborah A.; Coffey, Todd Stirling; Russo, Thomas V.; Schiek, Richard Louis; Warrender, Christina E.; Keiter, Eric Richard; Pawlowski, Roger Patrick

    2011-05-01

    This document is a reference guide to the Xyce Parallel Electronic Simulator, and is a companion document to the Xyce Users Guide. The focus of this document is (to the extent possible) exhaustively list device parameters, solver options, parser options, and other usage details of Xyce. This document is not intended to be a tutorial. Users who are new to circuit simulation are better served by the Xyce Users Guide. The Xyce Parallel Electronic Simulator has been written to support, in a rigorous manner, the simulation needs of the Sandia National Laboratories electrical designers. It is targeted specifically to run on large-scale parallel computing platforms but also runs well on a variety of architectures including single processor workstations. It also aims to support a variety of devices and models specific to Sandia needs. This document is intended to complement the Xyce Users Guide. It contains comprehensive, detailed information about a number of topics pertinent to the usage of Xyce. Included in this document is a netlist reference for the input-file commands and elements supported within Xyce; a command line reference, which describes the available command line arguments for Xyce; and quick-references for users of other circuit codes, such as Orcad's PSpice and Sandia's ChileSPICE.

  12. Quantum random number generator

    Science.gov (United States)

    Pooser, Raphael C.

    2016-05-10

    A quantum random number generator (QRNG) and a photon generator for a QRNG are provided. The photon generator may be operated in a spontaneous mode below a lasing threshold to emit photons. Photons emitted from the photon generator may have at least one random characteristic, which may be monitored by the QRNG to generate a random number. In one embodiment, the photon generator may include a photon emitter and an amplifier coupled to the photon emitter. The amplifier may enable the photon generator to be used in the QRNG without introducing significant bias in the random number and may enable multiplexing of multiple random numbers. The amplifier may also desensitize the photon generator to fluctuations in power supplied thereto while operating in the spontaneous mode. In one embodiment, the photon emitter and amplifier may be a tapered diode amplifier.

  13. Really big numbers

    CERN Document Server

    Schwartz, Richard Evan

    2014-01-01

    In the American Mathematical Society's first-ever book for kids (and kids at heart), mathematician and author Richard Evan Schwartz leads math lovers of all ages on an innovative and strikingly illustrated journey through the infinite number system. By means of engaging, imaginative visuals and endearing narration, Schwartz manages the monumental task of presenting the complex concept of Big Numbers in fresh and relatable ways. The book begins with small, easily observable numbers before building up to truly gigantic ones, like a nonillion, a tredecillion, a googol, and even ones too huge for names! Any person, regardless of age, can benefit from reading this book. Readers will find themselves returning to its pages for a very long time, perpetually learning from and growing with the narrative as their knowledge deepens. Really Big Numbers is a wonderful enrichment for any math education program and is enthusiastically recommended to every teacher, parent and grandparent, student, child, or other individual i...

  14. Genetics by the Numbers

    Science.gov (United States)

    ... View All Articles | Inside Life Science Home Page Genetics by the Numbers By Chelsea Toledo and Kirstie ... June 11, 2012 Scholars have been studying modern genetics since the mid-19th century, but even today ...

  15. Drawing a random number

    DEFF Research Database (Denmark)

    Wanscher, Jørgen Bundgaard; Sørensen, Majken Vildrik

    2006-01-01

    highly uniform multidimensional draws, which are highly relevant for todays traffic models. This paper shows among others combined shuffling and scrambling seems needless, that scrambling gives the lowest correlation and that there are detectable differences between random numbers, dependent...

  16. Logo and Negative Numbers.

    Science.gov (United States)

    Strawn, Candace A.

    1998-01-01

    Describes LOGO's turtle graphics capabilities based on a sixth-grade classroom's activities with negative numbers and Logo programming. A sidebar explains LOGO and offers suggestions to teachers for using LOGO effectively. (LRW)

  17. Solar Indices - Sunspot Numbers

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Collection includes a variety of indices related to solar activity contributed by a number of national and private solar observatories located worldwide. This...

  18. Quantum random number generators

    Science.gov (United States)

    Herrero-Collantes, Miguel; Garcia-Escartin, Juan Carlos

    2017-01-01

    Random numbers are a fundamental resource in science and engineering with important applications in simulation and cryptography. The inherent randomness at the core of quantum mechanics makes quantum systems a perfect source of entropy. Quantum random number generation is one of the most mature quantum technologies with many alternative generation methods. This review discusses the different technologies in quantum random number generation from the early devices based on radioactive decay to the multiple ways to use the quantum states of light to gather entropy from a quantum origin. Randomness extraction and amplification and the notable possibility of generating trusted random numbers even with untrusted hardware using device-independent generation protocols are also discussed.

  19. Chemical Diversity of Metabolites from Fungi, Cyanobacteria, and Plants Relative to FDA-Approved Anticancer Agents.

    Science.gov (United States)

    El-Elimat, Tamam; Zhang, Xiaoli; Jarjoura, David; Moy, Franklin J; Orjala, Jimmy; Kinghorn, A Douglas; Pearce, Cedric J; Oberlies, Nicholas H

    2012-07-12

    A collaborative project has been undertaken to explore filamentous fungi, cyanobacteria, and tropical plants for anti-cancer drug leads. Through principal component analysis, the chemical space covered by compounds isolated and characterized from these three sources over the last four years was compared to each other and to the chemical space of selected FDA-approved anticancer drugs. Using literature precedence, nine molecular descriptors were examined: molecular weight, number of chiral centers, number of rotatable bonds, number of acceptor atoms for H-bonds (N,O,F), number of donor atoms for H-bonds (N and O), topological polar surface area using N,O polar contributions, Moriguchi octanol-water partition coefficient, number of nitrogen atoms, and number of oxygen atoms. Four principal components explained 87% of the variation found among 343 bioactive natural products and 96 FDA-approved anticancer drugs. Across the four dimensions, fungal, cyanobacterial and plant isolates occupied both similar and distinct areas of chemical space that collectively aligned well with FDA-approved anticancer agents. Thus, examining three separate re-sources for anticancer drug leads yields compounds that probe chemical space in a complementary fashion.

  20. Fibonacci's Forgotten Number

    Science.gov (United States)

    Brown, Ezra; Brunson, Cornelius

    2008-01-01

    Fibonacci's forgotten number is the sexagesimal number 1;22,7,42,33,4,40, which he described in 1225 as an approximation to the real root of x[superscript 3] + 2x[superscript 2] + 10x - 20. In decimal notation, this is 1.36880810785...and it is correct to nine decimal digits. Fibonacci did not reveal his method. How did he do it? There is also a…

  1. Improved scatterometry time-to-solution using virtual reference

    Science.gov (United States)

    Vaid, Alok; Iddawela, Givantha; Tsai, Jamie; Wainreb, Gilad; Isbester, Paul; Kang, Byung Cheol (Charles); Klots, Michael; Katz, Yinon; Bozdog, Cornel; Sendelbach, Matt

    2015-03-01

    Advanced nodes require precise detection and control of intricate profile details - scatterometry is tool of choice for such requirements. Scatterometry is a model-based technique, and needs extensive reference metrology for qualification. Such reference measurements are costly, time-consuming and often destructive causing delays in deployment. With increasing number of scatterometry steps in flow, and the requirement to collect more reference data points to statistically qualify shrinking metrology specifications, the cost and time for reference metrology is exponentially increasing. This work is aimed to significantly reduce this need. We developed a novel methodology whereby scatterometry spectral information itself is used to predict "virtual" reference data. We qualify this methodology on several key applications from 20nm and 14nm node. We find that performance of solution developed using proposed methodology is indeed similar to performance of solution obtained using real reference data, thereby significantly reducing the lead time to develop scatterometry solutions.

  2. Certified reference materials for testing of the presence/absence of Staphylococcus aureus enterotoxin A (SEA) in cheese.

    Science.gov (United States)

    Zeleny, Reinhard; Nia, Yacine; Schimmel, Heinz; Mutel, Isabelle; Hennekinne, Jacques-Antoine; Emteborg, Håkan; Charoud-Got, Jean; Auvray, Frédéric

    2016-08-01

    Staphylococcal enterotoxins (SEs) account for a substantial number of food-poisoning outbreaks. European legislation (Commission Regulation 1441/2007) stipulates the reference procedure for SE analysis in milk and dairy products, which is based on extraction, dialysis concentration and immunochemical detection using one of two approved assays (VIDAS(®) SET2, Ridascreen(®) SET Total). However, certified reference materials (CRMs) are lacking to support laboratories in performing reliable detection of Staphylococcus aureus enterotoxin A (SEA) in relevant matrices at sub-nanogram per gram levels. The certification of a set of three reference materials (blank and two SEA-containing materials) for testing of the presence/absence of SEA in cheese is described. The reference procedure was applied in an intercomparison with 15 laboratories, and results were reported in a qualitative manner (presence or absence of SEA in the sample). No false-negative or false-positive results were obtained. The certified values were stated as diagnostic specificity (blank material) or diagnostic sensitivity (SEA-containing materials) and were 100 % in all cases. Stability studies demonstrated suitable material stability when stored cooled or frozen. An in-house study on the recovery of SEA in the cheese materials using a double-sandwich enzyme-linked immunosorbent assay (ELISA) revealed comparable recovery values of around 45 % at the two spiking levels and in both the SEA-containing CRMs as well as blank CRM freshly spiked prior to analysis. The values were also comparable over time and among different analysts. The materials provide valuable support to laboratories for method validation and method performance verification and will increase the reliability of measuring SEA in cheese.

  3. The Ethics and Politics of Ethics Approval

    Science.gov (United States)

    Battin, Tim; Riley, Dan; Avery, Alan

    2014-01-01

    The regulatory scope of Human Research Ethics Committees can be problematic for a variety of reasons. Some scholars have argued the ethics approval process, for example, is antithetical to certain disciplines in the humanities and social sciences, while others are willing to give it qualified support. This article uses a case study to cast the…

  4. 40 CFR 52.2522 - Approval status.

    Science.gov (United States)

    2010-07-01

    ... provisions do not meet the requirements of 40 CFR 51.160 for scope. EPA also disapproves 45 CSR 13 section 9... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Approval status. 52.2522 Section 52.2522 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS...

  5. Approved Practices in Dairy Reproduction. Slide Script.

    Science.gov (United States)

    Roediger, Roger D.; Barr, Harry L.

    This slide script, part of a series of slide scripts designed for use in vocational agriculture classes, deals with approved practices in dairy reproduction. Included in the guide are narrations for use with 200 slides dealing with the following topics: the importance of good reproduction, the male and female roles in reproduction, selection of…

  6. 42 CFR 422.2266 - Deemed approval.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Deemed approval. 422.2266 Section 422.2266 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Medicare Advantage Marketing Requirements § 422.2266...

  7. 42 CFR 423.2266 - Deemed approval.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Deemed approval. 423.2266 Section 423.2266 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM VOLUNTARY MEDICARE PRESCRIPTION DRUG BENEFIT Part D Marketing Requirements §...

  8. 7 CFR 322.4 - Approved regions.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Approved regions. 322.4 Section 322.4 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of...

  9. 7 CFR 1425.4 - Approval.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS COOPERATIVE MARKETING ASSOCIATIONS § 1425.4 Approval. (a) For a cooperative to gain CMA status to participate in a marketing assistance loan or Loan deficiency... prepared in accordance with generally accepted accounting principles; (3) A copy of the articles...

  10. Perkins Bill is Approved by Congress

    Science.gov (United States)

    Cavanagh, Sean

    2006-01-01

    Career and technical education programs will face new pressure to show that they are academically rigorous and guiding high school students through a lineup of courses that prepares them for college or the workplace, under a bill approved by Congress. The reauthorization of the federal law known as the Perkins Act--dealing with what traditionally…

  11. Program and Course Approval Handbook. Fifth Edition

    Science.gov (United States)

    California Community Colleges, Chancellor's Office, 2013

    2013-01-01

    This "Program and Course Approval Handbook" assists California Community College (CCC) administrators, faculty, and staff in the development of programs and courses and the submission of these proposals for review by the Chancellor's Office. By law, the Chancellor is required to prepare and distribute a handbook for program and course…

  12. 7 CFR 3565.103 - Approval requirements.

    Science.gov (United States)

    2010-01-01

    ... lender must provide the Agency with an annual audited financial statement conducted in accordance with... reserves, to have an acceptable level of financial soundness as determined by a lender rating service (such... AGRICULTURE GUARANTEED RURAL RENTAL HOUSING PROGRAM Lender Requirements § 3565.103 Approval requirements....

  13. Approval of Spouse in Middle Age.

    Science.gov (United States)

    Troll, Lillian E.

    A strongly positive opinion of spouse in middle age tends to be associated with social conformity and family integration. Mutually approving couples were more often politically moderate, homogamous in religious background, and had more interpersonal power than their children. They also had more highly integrated family structures with low conflict…

  14. 7 CFR 3015.112 - Approval procedures.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Approval procedures. 3015.112 Section 3015.112 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL OFFICER, DEPARTMENT OF AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Programmatic Changes and Budget...

  15. Reflections on the Ethics-Approval Process

    Science.gov (United States)

    Murray, Lee; Pushor, Debbie; Renihan, Pat

    2012-01-01

    It is sometimes a difficult journey receiving ethics approval for research involving vulnerable populations, research involving our own children, or innovative research methodologies such as autoethnography. This autoethnographical account is a story about one student who wanted to write a PhD dissertation in a very different way and also the…

  16. 28 CFR 549.51 - Approval procedures.

    Science.gov (United States)

    2010-07-01

    ... SERVICES Plastic Surgery § 549.51 Approval procedures. The Clinical Director shall consider individually any request from an inmate or a BOP medical consultant. (a) In circumstances where plastic surgery is... the Clinical Director recommends plastic surgery for the good order and security of the...

  17. 40 CFR 1042.210 - Preliminary approval.

    Science.gov (United States)

    2010-07-01

    ... specific provisions that apply for deterioration factors. Decisions made under this section are considered... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Preliminary approval. 1042.210 Section 1042.210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION...

  18. 40 CFR 52.373 - Approval status.

    Science.gov (United States)

    2010-07-01

    ... approves the total suspended particulate regulation for foundry sand processes as submitted and identified... the particulate matter and not the requirement to emit not more than 0.75 pounds of particulate per ton of material cast, a provision which may be found in state regulation 19-508-18(f)(3)....

  19. 7 CFR 52.53 - Approved identification.

    Science.gov (United States)

    2010-01-01

    ...) When graded against a U.S. grade standard, meet the quality requirements for U.S Grade C or better; (5) Meet applicable fill weight and/or drained weight, Brix or other characteristics of a commodity related... approved by USDA inspection service prior to use. (b) Inspection (Continuous) grade and inspection...

  20. Generating application ontologies from reference ontologies.

    Science.gov (United States)

    Shaw, Marianne; Detwiler, Landon T; Brinkley, James F; Suciu, Dan

    2008-11-06

    The semantic web provides the possiblity of linking together large numbers of biomedical ontologies. Unfortunately, many of the biomedical ontologies that have been developed are domain-specific and do not share a common structure that will allow them to be easily combined. Reference ontologies provide the necessary ontological framework for linking together these smaller, specialized ontologies. We present extensions to the semantic web query language SparQL that will allow researchers to develop application ontologies that are derived from reference ontologies. We have modified the ARQ query processor to support subqueries, recursive subqueries, and Skolem functions for node creation. We demonstrate the utility of these extensions by deriving an application ontology from the Foundational Model of Anatomy.

  1. Graphite thermal expansion reference for high temperature

    Science.gov (United States)

    Gaal, P. S.

    1974-01-01

    The design requirements of the aerospace and high-temperature nuclear reactor industries necessitate reliable thermal expansion data for graphite and other carbonaceous materials. The feasibility of an acceptable reference for calibration of expansion measuring systems that operate in carbon-rich atmospheres at temperatures ranging to 2500 C is the prime subject of this work. Present-day graphite technology provides acceptable materials for stable, reproducible references, as reflected by some of the candidate materials. The repeatability for a single specimen in a given expansion measuring system was found to be plus or minus 1%, while the combined results of several tests made on a number of samples fell within a plus or minus 2.5% band.

  2. The Preliminaries of a Reference

    DEFF Research Database (Denmark)

    Butler, Graham; Sadl, Urska

    2017-01-01

    by the reasons why the Court after an oral hearing held in the presence of the parties and eight intervening Member States, and after hearing the Advocate General did not deliver one. The comment examines the legal framework, as well as the detailed procedural rules and guidelines that govern the cooperation...... of national courts in the preliminary reference procedure. It highlights the fact that preliminary references can only work when the preliminaries of a reference – the culture of sincere cooperation and litigation, efficient communication and flexible procedural rules – are in place....

  3. Fraction Multiplication and Division Models: A Practitioner Reference Paper

    Science.gov (United States)

    Ervin, Heather K.

    2017-01-01

    It is well documented in literature that rational number is an important area of understanding in mathematics. Therefore, it follows that teachers and students need to have an understanding of rational number and related concepts such as fraction multiplication and division. This practitioner reference paper examines models that are important to…

  4. Report number codes

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, R.N. (ed.)

    1985-05-01

    This publication lists all report number codes processed by the Office of Scientific and Technical Information. The report codes are substantially based on the American National Standards Institute, Standard Technical Report Number (STRN)-Format and Creation Z39.23-1983. The Standard Technical Report Number (STRN) provides one of the primary methods of identifying a specific technical report. The STRN consists of two parts: The report code and the sequential number. The report code identifies the issuing organization, a specific program, or a type of document. The sequential number, which is assigned in sequence by each report issuing entity, is not included in this publication. Part I of this compilation is alphabetized by report codes followed by issuing installations. Part II lists the issuing organization followed by the assigned report code(s). In both Parts I and II, the names of issuing organizations appear for the most part in the form used at the time the reports were issued. However, for some of the more prolific installations which have had name changes, all entries have been merged under the current name.

  5. Japanese government takes steps toward approving birth control pill.

    Science.gov (United States)

    1995-10-27

    On September 12, 1995, the Central Pharmaceutical Affairs Council of Japan recommended approval of low-dose oral contraceptives as a method of family planning. Doctors should be able to prescribe the pills after the standing members of the Council, part of the Ministry of Health and Family Welfare, meet next March. High-dose oral contraceptives can be obtained currently to treat menstrual irregularities, although many of the 200,000 prescriptions written annually are used for family planning. Approval for the low-dose contraceptives has been slow because of concerns regarding a possible relaxation of sexual mores (1965); adverse side effects (until 1987 when the Japanese Ministry of Health initiated clinical trials that established the safety and efficacy of the contraceptives); increased rates of human immunodeficiency virus (HIV) infection (1992); a higher number of drug reimbursement claims under the national health insurance system; and a decline in Japan's birthrate. Japan's birthrate fell from 4.5 children per woman in 1947 to 1.5 in 1993. 80% of contraceptive users rely on condom; 22% use the rhythm method, usually in conjunction with the condom; 7% use the IUD; and less than 2% use sterilization. Sterilization is only permitted for married couples and only when the woman's life or health is in danger, or either spouse has a mental illness, leprosy, or a hereditary disorder.

  6. The LHC in numbers

    CERN Multimedia

    Alizée Dauvergne

    2010-01-01

    What makes the LHC the biggest particle accelerator in the world? Here are some of the numbers that characterise the LHC, and their equivalents in terms that are easier for us to imagine.   Feature Number Equivalent Circumference ~ 27 km   Distance covered by beam in 10 hours ~ 10 billion km a round trip to Neptune Number of times a single proton travels around the ring each second 11 245   Speed of protons first entering the LHC 299 732 500 m/s 99.9998 % of the speed of light Speed of protons when they collide 299 789 760 m/s 99.9999991 % of the speed of light Collision temperature ~ 1016 °C ove...

  7. Chromosome numbers in Bromeliaceae

    Directory of Open Access Journals (Sweden)

    Cotias-de-Oliveira Ana Lúcia Pires

    2000-01-01

    Full Text Available The present study reports chromosome numbers of 17 species of Bromeliaceae, belonging to the genera Encholirium, Bromelia, Orthophytum, Hohenbergia, Billbergia, Neoglaziovia, Aechmea, Cryptanthus and Ananas. Most species present 2n = 50, however, Bromelia laciniosa, Orthophytum burle-marxii and O. maracasense are polyploids with 2n = 150, 2n = 100 and 2n = 150, respectively, while for Cryptanthus bahianus, 2n = 34 + 1-4B. B chromosomes were observed in Bromelia plumieri and Hohenbergia aff. utriculosa. The chromosome number of all species was determined for the first time, except for Billbergia chlorosticta and Cryptanthus bahianus. Our data supports the hypothesis of a basic number of x = 25 for the Bromeliaceae family and decreasing aneuploidy in the genus Cryptanthus.

  8. Quantum random number generation

    Science.gov (United States)

    Ma, Xiongfeng; Yuan, Xiao; Cao, Zhu; Qi, Bing; Zhang, Zhen

    2016-06-01

    Quantum physics can be exploited to generate true random numbers, which have important roles in many applications, especially in cryptography. Genuine randomness from the measurement of a quantum system reveals the inherent nature of quantumness—coherence, an important feature that differentiates quantum mechanics from classical physics. The generation of genuine randomness is generally considered impossible with only classical means. On the basis of the degree of trustworthiness on devices, quantum random number generators (QRNGs) can be grouped into three categories. The first category, practical QRNG, is built on fully trusted and calibrated devices and typically can generate randomness at a high speed by properly modelling the devices. The second category is self-testing QRNG, in which verifiable randomness can be generated without trusting the actual implementation. The third category, semi-self-testing QRNG, is an intermediate category that provides a tradeoff between the trustworthiness on the device and the random number generation speed.

  9. Directory of Certificates of Compliance for radioactive materials packages: Report of NRC approved quality assurance programs for radioactive materials packages. Volume 3, Revision 15

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-10-01

    The purpose of this directory is to make available a convenient source of information on packagings which have been approved by the US Nuclear Regulatory Commission. To assist in identifying packaging, an index by Model Number and corresponding Certificate of Compliance Number is included at the front of Volumes 1 and 2. An alphabetical listing by user name is included in the back of Volume 3 of approved QA programs. The reports include a listing of all users of each package design and approved QA programs prior to the publication date.

  10. Genetics Home Reference: warfarin resistance

    Science.gov (United States)

    ... novel VKORC1 mutations associated with oral anticoagulant resistance: insights into improved patient diagnosis and treatment. J Thromb ... healthcare professional . About Genetics Home Reference Site Map Customer Support Selection Criteria for Links USA.gov Copyright ...

  11. Genetics Home Reference: Canavan disease

    Science.gov (United States)

    ... disease, a rare early-onset human spongiform leukodystrophy: insights into its genesis and possible clinical interventions. Biochimie. ... healthcare professional . About Genetics Home Reference Site Map Customer Support Selection Criteria for Links USA.gov Copyright ...

  12. Genetics Home Reference: Vohwinkel syndrome

    Science.gov (United States)

    ... of connexins in ear and skin physiology - functional insights from disease-associated mutations. Biochim Biophys Acta. 2013 ... healthcare professional . About Genetics Home Reference Site Map Customer Support Selection Criteria for Links USA.gov Copyright ...

  13. Genetics Home Reference: Larsen syndrome

    Science.gov (United States)

    ... affinity in the absence of major structural disturbance: Insights from the crystal structures of filamin B actin ... healthcare professional . About Genetics Home Reference Site Map Customer Support Selection Criteria for Links USA.gov Copyright ...

  14. Genetics Home Reference: Brugada syndrome

    Science.gov (United States)

    ... rare variation in arrhythmia-susceptibility genes provides new insights into molecular diagnosis for Brugada syndrome. Hum Mol ... healthcare professional . About Genetics Home Reference Site Map Customer Support Selection Criteria for Links USA.gov Copyright ...

  15. Genetics Home Reference: psoriatic arthritis

    Science.gov (United States)

    ... PubMed Nograles KE, Brasington RD, Bowcock AM. New insights into the pathogenesis and genetics of psoriatic arthritis. ... healthcare professional . About Genetics Home Reference Site Map Customer Support Selection Criteria for Links USA.gov Copyright ...

  16. Genetics Home Reference: boomerang dysplasia

    Science.gov (United States)

    ... affinity in the absence of major structural disturbance: Insights from the crystal structures of filamin B actin ... healthcare professional . About Genetics Home Reference Site Map Customer Support Selection Criteria for Links USA.gov Copyright ...

  17. Genetics Home Reference: Meckel syndrome

    Science.gov (United States)

    ... genetics and pathogenic mechanisms for the severe ciliopathies: insights into neurodevelopment and pathogenesis of neural tube defects. ... healthcare professional . About Genetics Home Reference Site Map Customer Support Selection Criteria for Links USA.gov Copyright ...

  18. Genetics Home Reference: Brody myopathy

    Science.gov (United States)

    ... Kuppevelt TH, Ferlini A, Tomelleri G. Brody disease: insights into biochemical features of SERCA1 and identification of ... healthcare professional . About Genetics Home Reference Site Map Customer Support Selection Criteria for Links USA.gov Copyright ...

  19. Genetics Home Reference: hidradenitis suppurativa

    Science.gov (United States)

    ... JN. γ-Secretase mutations in hidradenitis suppurativa: new insights into disease pathogenesis. J Invest Dermatol. 2013 Mar; ... healthcare professional . About Genetics Home Reference Site Map Customer Support Selection Criteria for Links USA.gov Copyright ...

  20. Genetics Home Reference: Wolfram syndrome

    Science.gov (United States)

    ... V. Genotypic classification of patients with Wolfram syndrome: insights into the natural history of the disease and ... healthcare professional . About Genetics Home Reference Site Map Customer Support Selection Criteria for Links USA.gov Copyright ...

  1. Crescent Lake Wilderness Reference Sheet

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Reference sheet includes information about Crescent Lake National Wildlife Refuge, and results of the public hearing for Crescent Lake Wilderness Proposal.

  2. Algebraic theory of numbers

    CERN Document Server

    Samuel, Pierre

    2008-01-01

    Algebraic number theory introduces students not only to new algebraic notions but also to related concepts: groups, rings, fields, ideals, quotient rings and quotient fields, homomorphisms and isomorphisms, modules, and vector spaces. Author Pierre Samuel notes that students benefit from their studies of algebraic number theory by encountering many concepts fundamental to other branches of mathematics - algebraic geometry, in particular.This book assumes a knowledge of basic algebra but supplements its teachings with brief, clear explanations of integrality, algebraic extensions of fields, Gal

  3. CONFUSION WITH TELEPHONE NUMBERS

    CERN Document Server

    Telecom Service

    2002-01-01

    The area code is now required for all telephone calls within Switzerland. Unfortunately this is causing some confusion. CERN has received complaints that incoming calls intended for CERN mobile phones are being directed to private subscribers. This is caused by mistakenly dialing the WRONG code (e.g. 022) in front of the mobile number. In order to avoid these problems, please inform your correspondents that the correct numbers are: 079 201 XXXX from Switzerland; 0041 79 201 XXXX from other countries. Telecom Service  

  4. CONFUSION WITH TELEPHONE NUMBERS

    CERN Document Server

    Telecom Service

    2002-01-01

    he area code is now required for all telephone calls within Switzerland. Unfortunately this is causing some confusion. CERN has received complaints that incoming calls intended for CERN mobile phones are being directed to private subscribers. This is caused by mistakenly dialing the WRONG code (e.g. 022) in front of the mobile number. In order to avoid these problems, please inform your correspondents that the correct numbers are: 079 201 XXXX from Switzerland; 0041 79 201 XXXX from other countries. Telecom Service

  5. Minimal Niven Numbers

    Science.gov (United States)

    2007-12-26

    265–275. [7] H. G. Grundman, ‘ Sequences of consecutive Niven numbers’, Fibonacci Quart. 32 (1994), 174–175. [8] D. R. Heath-Brown and S. Konyagin...paper, we define a natural sequence in relation to q-Niven numbers. For a fixed but arbitrary k ∈ N and a base q ≥ 2, one may ask whether or not there...other words, ak is the smallest Niven number whose sum of the digits is a given positive integer k. We denote by ck the companion sequence ck = ak/k

  6. An analysis of FDA-approved drugs for inflammation and autoimmune diseases.

    Science.gov (United States)

    Kinch, Michael S; Merkel, Janie

    2015-08-01

    The term 'inflammation' captures a variety of disease processes linked with the immune system. An analysis of US Food and Drug Administration (FDA)-approved nuclear molecular entities (NMEs) reveals notable trends in terms of acute and chronic inflammatory indications. The number of NMEs peaked during the 1990s and has since declined by more than 50%. Whereas pharmaceutical companies have dominated the field, biotechnology companies now receive half of new approvals and academia has a relatively large role in terms of pivotal first patents. Another notable trend is that the relative number of NMEs targeting allergy has been decreasing, whereas those targeting autoimmune indications is increasing. Unlike other indications, NMEs for inflammation tend towards nuclear receptors and cytokines, and a disproportionate number of biologics target cytokine pathways.

  7. Approved Drug Products with Therapuetic Equivalence Evaluations (Orange Book)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The publication Approved Drug Products with Therapeutic Equivalence Evaluations (the List, commonly known as the Orange Book) identifies drug products approved on...

  8. 46 CFR 162.050-23 - Separator: Approval tests.

    Science.gov (United States)

    2010-10-01

    ...: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Pollution Prevention Equipment § 162.050-23 Separator: Approval... hour, the separator must be inclined at an angle of 22.5° with the plane of its normal...

  9. FDA Approves New Treatment for Dust Mite Allergies

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_163882.html FDA Approves New Treatment for Dust Mite Allergies Odactra ... life," said Dr. Peter Marks, director of the FDA's Center for Biologics Evaluation and Research. "The approval ...

  10. [New drug approvals over three decades from 1980 to 2009 in Japan--their therapeutic targets and biochemical properties].

    Science.gov (United States)

    Muramatsu, Makoto; Arisue, Yumiko

    2011-04-01

    We analyzed the therapeutic target molecules and biochemical properties of 893 new drugs with new molecular entities approved over three decades from 1980 to 2009 in Japan. According to our analysis of the therapeutic targets, 26.2% of new drugs were enzymes. Membrane receptors were found to be the second-most frequent molecular targets of the new drugs, representing 25.3% of the new drugs approved. The biochemical properties of the drugs were found to have changed over time. Though the total number of new drugs approved from the year 2000 was smaller than that in the 1980s and 1990s, the number of new protein drugs approved in the 2000s, largely recombinant bioactive substances and monoclonal antibodies, increased significantly compared with those approved in the 1980s and 1990s. The results obtained in this study indicated changes in the therapeutic targets, biochemical properties and therapeutic areas of new drugs approved over the last 30 years and suggest the aspects of the future development of new drugs.

  11. World Reference Center for Arboviruses.

    Science.gov (United States)

    1985-01-01

    viruses from many parts of the world. 7 %, 1.1%vl ’ e- "., Distribution of reagents. The reference center distributed 970 ampoules of reference sera...eight pools of Culiseta melanura collected during 1984 as part of a field study on Lyme disease and other zoonoses in Connecticut. A ninth strain was...dense amorphous masses, were present also in the cytoplasm. Smooth-surfaced reticula occurred in the cytoplasm and contained viral particles in

  12. Virtual reference: chat with us!

    Science.gov (United States)

    Lapidus, Mariana; Bond, Irena

    2009-01-01

    Virtual chat services represent an exciting way to provide patrons of medical libraries with instant reference help in an academic environment. The purpose of this article is to examine the implementation, marketing process, use, and development of a virtual reference service initiated at the Massachusetts College of Pharmacy and Health Sciences and its three-campus libraries. In addition, this paper will discuss practical recommendations for the future improvement of the service.

  13. TclTk Pocket Reference

    CERN Document Server

    Raines, Paul

    1998-01-01

    The Tcl/Tk combination is increasingly popular because it lets you produce sophisticated graphical interfaces with a few easy commands, develop and change scripts quickly, and conveniently tie together existing utilities or programming libraries. The Tcl/Tk Pocket Reference,a handy reference guide to the basic Tcl language elements, Tcl and Tk commands, and Tk widgets, is a companion volume to Tcl/Tk in a Nutshell.

  14. The role of references in the astronomical discourse

    CERN Document Server

    Girard, R

    1996-01-01

    We have counted the number of references in 1179 papers published in Astronomy and Astrophysics over twenty years. The number of references has increased by 60% between 1975 and 1995, reflecting the increase (by the same amount) of the literature which must be cited, and of the number of pages per paper. There are 1.5 times more references in predominantly observational fields than in others. References are used 1.65 times in the text, and there is no trend with time or field. They appear mostly in the introduction (30%) and in the main body of the paper (60%), but papers in predominantly observational fields tend to use less references in the introduction and more in the main body than papers in the other fields. Most references (62%) serve to support a result, and tend to be of theoretical nature. Astronomers are a very conformist bunch, as there are no trends with nationality, and references to conflicting evidence are kept at about 8%. The analysis of a series of papers by de Vaucouleurs on the Hubble con...

  15. Referring Expressions: A Unified Approach

    Institute of Scientific and Technical Information of China (English)

    K.M. Jaszczolt

    2001-01-01

    @@ 0. Introduction Expressions used by speakers to refer are commonly divided into two categories: that of directly referring expressions and that of expressions whose referring function is secured by the context of utterance. Directly referring expressions are normally said to include proper names, some pronouns including demonstrative, and demonstrative phrases. The other category comprises mainly definite and indefinite descriptions, the first being their most acclaimed representative. Definite descriptions are widely acknowledged to have referential uses. They are not referring expressions, so to speak, by default,but rather as a result of a contextually determined interpretation. As a category, they are frequently said to belong with quantifiers (Neale 1990; Recanati 1993). However, the arguments for classifying them with referring expressions are ample (Bach 1987a; Larson & Segal 1995; Brown 1995; Jaszczolt 1997a,1997b, 1999b). It is argued in Part I of this paper that although definite descriptions exhibit an ambiguity of use between the referential and the attributive reading, they also exhibit the property of having an unmarked, salient interpretation which makes them akin to directly referential terms. This salient reading is the referential interpretation, arrived at with the help of the hearer′s presumption of the presence of strong referential intention that supports the speaker′s utterance.

  16. Korean Reference HLW Disposal System

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Heui Joo; Lee, J. Y.; Kim, S. S. (and others)

    2008-03-15

    This report outlines the results related to the development of Korean Reference Disposal System for High-level radioactive wastes. The research has been supported around for 10 years through a long-term research plan by MOST. The reference disposal method was selected via the first stage of the research during which the technical guidelines for the geological disposal of HLW were determined too. At the second stage of the research, the conceptual design of the reference disposal system was made. For this purpose the characteristics of the reference spent fuels from PWR and CANDU reactors were specified, and the material and specifications of the canisters were determined in term of structural analysis and manufacturing capability in Korea. Also, the mechanical and chemical characteristics of the domestic Ca-bentonite were analyzed in order to supply the basic design parameters of the buffer. Based on these parameters the thermal and mechanical analysis of the near-field was carried out. Thermal-Hydraulic-Mechanical behavior of the disposal system was analyzed. The reference disposal system was proposed through the second year research. At the final third stage of the research, the Korean Reference disposal System including the engineered barrier, surface facilities, and underground facilities was proposed through the performance analysis of the disposal system.

  17. Haida Numbers and Calculation.

    Science.gov (United States)

    Cogo, Robert

    Experienced traders in furs, blankets, and other goods, the Haidas of the 1700's had a well-developed decimal system for counting and calculating. Their units of linear measure included the foot, yard, and fathom, or six feet. This booklet lists the numbers from 1 to 20 in English and Haida; explains the Haida use of ten, hundred, and thousand…

  18. Introducing Complex Numbers

    Science.gov (United States)

    Trudgian, Timothy

    2009-01-01

    One of the difficulties in any teaching of mathematics is to bridge the divide between the abstract and the intuitive. Throughout school one encounters increasingly abstract notions, which are more and more difficult to relate to everyday experiences. This article examines a familiar approach to thinking about negative numbers, that is an…

  19. Surveys in Number Theory

    CERN Document Server

    Alladi, Krishnaswami

    2008-01-01

    Contains chapters on number theory and related topics. This title covers topics that focus on multipartitions, congruences and identities, the formulas of Koshliakov and Guinand in Ramanujan's "Lost Notebook", alternating sign matrices and the Weyl character formulas, theta functions in complex analysis, and elliptic functions

  20. The magic of numbers

    CERN Document Server

    Bell, Eric Temple

    1991-01-01

    From one of the foremost interpreters for lay readers of the history and meaning of mathematics: a stimulating account of the origins of mathematical thought and the development of numerical theory. It probes the work of Pythagoras, Galileo, Berkeley, Einstein, and others, exploring how ""number magic"" has influenced religion, philosophy, science, and mathematics

  1. Revisiting the Sunspot Number

    CERN Document Server

    Clette, Frédéric; Vaquero, José M; Cliver, Edward W

    2014-01-01

    Our knowledge of the long-term evolution of solar activity and of its primary modulation, the 11-year cycle, largely depends on a single direct observational record: the visual sunspot counts that retrace the last 4 centuries, since the invention of the astronomical telescope. Currently, this activity index is available in two main forms: the International Sunspot Number initiated by R. Wolf in 1849 and the Group Number constructed more recently by Hoyt and Schatten (1998a,b). Unfortunately, those two series do not match by various aspects, inducing confusions and contradictions when used in crucial contemporary studies of the solar dynamo or of the solar forcing on the Earth climate. Recently, new efforts have been undertaken to diagnose and correct flaws and biases affecting both sunspot series, in the framework of a series of dedicated Sunspot Number Workshops. Here, we present a global overview of our current understanding of the sunspot number calibration. While the early part of the sunspot record befor...

  2. Baryon Number Violation

    CERN Document Server

    Babu, K S; Al-Binni, U; Banerjee, S; Baxter, D V; Berezhiani, Z; Bergevin, M; Bhattacharya, S; Brice, S; Brock, R; Burgess, T W; Castellanos, L; Chattopadhyay, S; Chen, M-C; Church, E; Coppola, C E; Cowen, D F; Cowsik, R; Crabtree, J A; Davoudiasl, H; Dermisek, R; Dolgov, A; Dutta, B; Dvali, G; Ferguson, P; Perez, P Fileviez; Gabriel, T; Gal, A; Gallmeier, F; Ganezer, K S; Gogoladze, I; Golubeva, E S; Graves, V B; Greene, G; Handler, T; Hartfiel, B; Hawari, A; Heilbronn, L; Hill, J; Jaffe, D; Johnson, C; Jung, C K; Kamyshkov, Y; Kerbikov, B; Kopeliovich, B Z; Kopeliovich, V B; Korsch, W; Lachenmaier, T; Langacker, P; Liu, C-Y; Marciano, W J; Mocko, M; Mohapatra, R N; Mokhov, N; Muhrer, G; Mumm, P; Nath, P; Obayashi, Y; Okun, L; Pati, J C; Pattie, R W; Phillips, D G; Quigg, C; Raaf, J L; Raby, S; Ramberg, E; Ray, A; Roy, A; Ruggles, A; Sarkar, U; Saunders, A; Serebrov, A; Shafi, Q; Shimizu, H; Shiozawa, M; Shrock, R; Sikdar, A K; Snow, W M; Soha, A; Spanier, S; Stavenga, G C; Striganov, S; Svoboda, R; Tang, Z; Tavartkiladze, Z; Townsend, L; Tulin, S; Vainshtein, A; Van Kooten, R; Wagner, C E M; Wang, Z; Wehring, B; Wilson, R J; Wise, M; Yokoyama, M; Young, A R

    2013-01-01

    This report, prepared for the Community Planning Study - Snowmass 2013 - summarizes the theoretical motivations and the experimental efforts to search for baryon number violation, focussing on nucleon decay and neutron-antineutron oscillations. Present and future nucleon decay search experiments using large underground detectors, as well as planned neutron-antineutron oscillation search experiments with free neutron beams are highlighted.

  3. Uniform random number generators

    Science.gov (United States)

    Farr, W. R.

    1971-01-01

    Methods are presented for the generation of random numbers with uniform and normal distributions. Subprogram listings of Fortran generators for the Univac 1108, SDS 930, and CDC 3200 digital computers are also included. The generators are of the mixed multiplicative type, and the mathematical method employed is that of Marsaglia and Bray.

  4. 40 CFR 86.1 - Reference materials.

    Science.gov (United States)

    2010-07-01

    ...-04, 86.1806-05. (xxviii) SAE J1978, Revised April 2002, OBD II Scan Tool—Equivalent to ISO/DIS 15031... known as On-board Diagnostics II (OBD-II), Approved on April 21, 2003, Title 13, California Code... Passenger Cars, Light-Duty Trucks, and Medium-Duty Vehicles and Engines (OBD-II), IBR approved for §...

  5. 28 CFR 551.11 - Authority to approve a marriage.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Authority to approve a marriage. 551.11... MISCELLANEOUS Marriages of Inmates § 551.11 Authority to approve a marriage. (a) The Warden may approve the marriage of a federal inmate confined in a federal institution. This authority may not be delegated...

  6. 50 CFR 15.26 - Approval of cooperative breeding programs.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false Approval of cooperative breeding programs... WILDLIFE AND PLANTS WILD BIRD CONSERVATION ACT Permits and Approval of Cooperative Breeding Programs § 15.26 Approval of cooperative breeding programs. Upon receipt of a complete application, the...

  7. 29 CFR 4221.14 - PBGC-approved arbitration procedures.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false PBGC-approved arbitration procedures. 4221.14 Section 4221... LIABILITY FOR MULTIEMPLOYER PLANS ARBITRATION OF DISPUTES IN MULTIEMPLOYER PLANS § 4221.14 PBGC-approved arbitration procedures. (a) Use of PBGC-approved arbitration procedures. In lieu of the procedures...

  8. 12 CFR 614.4470 - Loans subject to bank approval.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Loans subject to bank approval. 614.4470 Section 614.4470 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM LOAN POLICIES AND OPERATIONS Loan Approval Requirements § 614.4470 Loans subject to bank approval. (a) The following...

  9. 33 CFR 115.70 - Advance approval of bridges.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Advance approval of bridges. 115... BRIDGES BRIDGE LOCATIONS AND CLEARANCES; ADMINISTRATIVE PROCEDURES § 115.70 Advance approval of bridges. (a) The General Bridge Act of 1946 requires the approval of the location and plans of bridges...

  10. 14 CFR 21.269 - Export airworthiness approvals.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Export airworthiness approvals. 21.269 Section 21.269 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION....269 Export airworthiness approvals. The manufacturer may issue export airworthiness approvals....

  11. 76 FR 53526 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2011-08-26

    ... From the Federal Register Online via the Government Publishing Office SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule...

  12. 76 FR 42159 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2011-07-18

    ... From the Federal Register Online via the Government Publishing Office SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule...

  13. 27 CFR 24.26 - Authority to approve.

    Science.gov (United States)

    2010-04-01

    ..., DEPARTMENT OF THE TREASURY LIQUORS WINE Administrative and Miscellaneous Provisions Authorities § 24.26 Authority to approve. The appropriate TTB officer is authorized to approve, except as otherwise provided in... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Authority to approve....

  14. 48 CFR 32.409-1 - Recommendation for approval.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Recommendation for... Recommendation for approval. If recommending approval, the contracting officer shall transmit the following... authorization (see 32.410). (g) The recommendation for approval of the advance payment request....

  15. 29 CFR 4211.21 - Changes subject to PBGC approval.

    Science.gov (United States)

    2010-07-01

    ... method or modification to an allocation method that is not permitted under § 4211.12 if the method or... 29 Labor 9 2010-07-01 2010-07-01 false Changes subject to PBGC approval. 4211.21 Section 4211.21... Subject to PBGC Approval § 4211.21 Changes subject to PBGC approval. (a) General rule. Subject to...

  16. 44 CFR 78.9 - Planning grant approval process.

    Science.gov (United States)

    2010-10-01

    ... MITIGATION ASSISTANCE § 78.9 Planning grant approval process. The State POC will evaluate and approve... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Planning grant approval process. 78.9 Section 78.9 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT...

  17. 48 CFR 1845.607-170 - Contractor's approved scrap procedure.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor's approved scrap... Contractor Inventory 1845.607-170 Contractor's approved scrap procedure. (a) When a contractor has an approved scrap procedure, certain property may be routinely disposed of in accordance with that...

  18. 46 CFR 188.10-3 - Approved container.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Approved container. 188.10-3 Section 188.10-3 Shipping... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-3 Approved container. This term means a container which is properly labeled, marked and approved by DOT for the commodity which it contains....

  19. 7 CFR 996.22 - USDA-approved laboratory.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false USDA-approved laboratory. 996.22 Section 996.22 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... laboratory. USDA-approved laboratory means laboratories approved by the Science and Technology...

  20. Using Virtual Reference Transcripts for Staff Training.

    Science.gov (United States)

    Ward, David

    2003-01-01

    Describes a method of library staff training based on chat transcript analysis in which graduate student workers at a university reference desk examined transcripts of actual virtual reference desk transactions to analyze reference interviews. Discusses reference interview standards, reference desk behavior, and reference interview skills in…