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Sample records for approach esclerosis multiple

  1. Matrix Metalloproteinases in patients with Multiple Sclerosis. Metaloproteinasas de matriz en pacientes con esclerosis múltiple

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    Alina González-Quevedo Monteagudo

    2007-05-01

    Full Text Available Fundament: The proteolitic rupture of the extracellular matrix due to metalloproteinase 2 and 9 is one of the aspects that can influence in the alteration of the permeability of the blood-brain barrier (BBB in multiple sclerosis. Objective: To determine metalloproteinase activity with gelatinous activity in patients suffering from multiple sclerosis. Methods: the cerebrospinal fluid (CSF samples taken from 31 patients suffering from multiple sclerosis and a control group formed by 21 patients without neurological disease. The metalloproteinase 2 and 9 activities in the cerebrospinal fluid were determined by zimográfica technique through polyacrylamide gel electrophoresis. The bands were later analysed by their molecular weight and the relative metalloproteinase 9 activity was calculated. Total protein concentrations, albumin and immunoglobulin G (IgG, the IgG rate and the Q rate were assessed to evaluate the IgG intrathecal and the functional state of the blood-brain barrier. Results: metalloproteinase 2 activity was detected in the cerebrospinal fluid of all patients and control group. Metalloproteinase 9 activity was only found in the 61.3 % of the patients. The presence of relative metalloproteinase 9 activity was neither associated with the clinical variables nor the laboratory ones. An association was found between its presence and the oligoclonal bands in patients with multiple sclerosis. In those patients under immunomodular treatment it was presented with less frequency. Conclusions: There is a possible participation of Metalloproteinase 9 in the immunopathological mechanisms of the multiple sclerosis.

    Fundamento: La ruptura proteolítica de la matriz extracelular por las metaloproteinasas 2 y 9 es uno de los aspectos que puede influir en la alteración de la permeabilidad de la barrera hematoencefálica en la esclerosis m

  2. Compromiso neuronal en esclerosis múltiple Neuronal injury in multiple sclerosis

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    Jorge Correale

    2006-10-01

    Full Text Available La esclerosis múltiple (EM ha sido considerada clásicamente como una enfermedad desmielinizante. Si bien el compromiso neurodegenerativo fue previamente descripto, sólo recientemente ha sido enfatizado. Por estudios recientes se ha identificado la degeneración axonal como el mayor determinante de discapacidad neurológica irreversible en pacientes con EM. El daño axonal se inicia tempranamente y permanece silente durante años, la discapacidad neurológica se desarrolla cuando se alcanza cierto umbral de pérdida axonal y los mecanismos de compensación se agotan. Se han propuesto tres hipótesis para explicar el daño axonal: 1 El daño es causado por un proceso inflamatorio, 2 Existe una excesiva acumulación de Ca2+ intraaxonal, 3 Los axones desmielinizados evolucionan a un proceso degenerativo producto de la falta de soporte trófico provisto por la mielina o células formadoras de mielina. Si bien la EM fue tradicionalmente considerada como una enfermedad de la sustancia blanca, el proceso de desmielinización también ocurre en la corteza cerebral. Las lesiones corticales muestran injuria neuronal representada por transección de axones y dendritas, así como apoptosis de neuronas. Dado que los métodos convencionales de resonancia magnética nuclear (RMN son limitados en su capacidad para brindar información sobre el compromiso axonal en EM, procedimientos como tensor de difusión, espectroscopia por resonancia magnética, resonancia magnética funcional, y nuevas técnicas para medir atrofia han sido desarrollados recientemente para monitorear su evolución. El reconocimiento de que EM es en parte un proceso neurodegenerativo impone abordar de manera crítica la patogenia de la enfermedad, a fin de considerar nuevas estrategias de tratamiento.The concept of multiple sclerosis (MS as a demyelinating disease is deeply ingrained. Although the existence of a neurodegenerative component has always been apparent, it has only recently

  3. Esclerosis múltiple: alteraciones cognitivas y actividades de la vida diaria = Multiple sclerosis : cognitive impairments and activities of daily living

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    Alegre Ayala, Jorge

    2008-02-01

    Full Text Available RESUMENLas alteraciones cognitivas ocasionadas por la Esclerosis Múltiple (EM dificultan el desempeño ocupacional de estos pacientes. No existe un patrón específico de deterioro cognitivo aunque son comunes las afectaciones de la memoria, los procesos atencionales, la velocidad de procesamiento de la información, las funciones ejecutivas, la fluidez verbal y la capacidad visuoespacial. Pese a no ser tan conocidos como los problemas físicos, los déficit cognitivos provocan limitaciones en la capacidad de estas personas para realizar sus actividades de la vida diaria (AVD. El artículo muestra explicaciones sobre las principales alteraciones cognitivas de la enfermedad y ejemplos de actividades de la vida diaria dañadas por éstas. SUMMARY Cognitive impairments caused by Multiple Sclerosis make these patients´ occupational performance difficult. It is not exist a specific pattern of cognitive injury although they are usual the affections in memory, attention process, speed of information processing, executive functions, verbal fluency and visual and spatial skills. Though are not so known like physical problems, the cognitive deficits provokes limitations in the ability of these persons to realize their activities of daily living. Article shows explains about principal cognitive impairments and examples of damage in the activities of daily living caused by Multiple Sclerosis.

  4. Esclerosis múltiple en una mujer fallecida por quemaduras en el incendio del domicilio Multiple sclerosis in a woman died by burns in a house fire

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    J. Lucena

    2004-10-01

    Full Text Available La esclerosis múltiple (EM o esclerosis en placas es la más común de las enfermedades inflamatorias desmielinizantes del SNC y el trastorno neurológico más incapacitante en los adultos jóvenes. Se caracteriza por la aparición de lesiones focales diseminadas en la sustancia blanca denominadas placas en las que lo más llamativo es la pérdida de la mielina (desmielinización con preservación relativa de los axones. Es infrecuente que esta enfermedad entre en el campo de investigación médico-forense, ya que, habitualmente, está bien diagnosticada clínicamente y en caso de tener interés la confirmación del diagnóstico post-mortem se realizaría una autopsia clínica. Presentamos los hallazgos neuropatológicos de una mujer de 47 años, en situación de invalidez (silla de ruedas por una EM de 17 años de evolución, que fallece como consecuencia de las quemaduras producidas por un incendio en el domicilio.The multiple sclerosis (MS or plaque sclerosis is the most frequent of the inflammatory demyelinating diseases of the SNC and the most incapacitating neurological disorder in young adults. It is characterized by the presence of focal an scattered lesions in the white matter called plaques in which the hallmark is the loss of myelin (demyelination with the preservation of axons. It is uncommon that this disorder enters in the medico-legal field because, in general, has a very good clinical diagnosis and in case of interest to confirm the post-mortem diagnosis a clinical autopsy would be performed. We present the neuropathological findings of a woman aged 47 years, handicapped (wheel's chair due to MS with a progression of 17 years, who died by burns in a house fire.

  5. Esclerosis múltiple en una mujer fallecida por quemaduras en el incendio del domicilio Multiple sclerosis in a woman died by burns in a house fire

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    J. Lucena; M. Salguero; A. Rico; Blanco, M.; Marín, R.; E. Barrero; F. Heredia

    2004-01-01

    La esclerosis múltiple (EM) o esclerosis en placas es la más común de las enfermedades inflamatorias desmielinizantes del SNC y el trastorno neurológico más incapacitante en los adultos jóvenes. Se caracteriza por la aparición de lesiones focales diseminadas en la sustancia blanca denominadas placas en las que lo más llamativo es la pérdida de la mielina (desmielinización) con preservación relativa de los axones. Es infrecuente que esta enfermedad entre en el campo de investigación médico-for...

  6. Rol de las células T regulatorias en esclerosis múltiple Role of T-regulatory cells in multiple sclerosis

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    Juan Ignacio Rojas

    2010-02-01

    Full Text Available La esclerosis múltiple (EM es una enfermedad inflamatoria autoinmune desmielinizante del sistema nervioso central (SNC. La mayoría de las enfermedades autoinmunes se originan por la activación anormal de la respuesta inflamatoria contra auto-antígenos (la mayoría de ellos desconocidos a la fecha como consecuencia de la pérdida de la tolerancia periférica. Las células T-regulatorias constituyen un grupo esencial de linfocitos T encargados del mantenimiento de la tolerancia periférica, la prevención de enfermedades autoinmunes y la limitación de enfermedades inflamatorias crónicas. Teniendo en cuenta la importancia de la tolerancia periférica, las células T-regulatorias serían componentes cruciales en el escenario fisiopatológico de los procesos autoinmunes, incluyendo la EM. El presente trabajo recopila los conocimientos actuales sobre la función de las células T-regulatorias en la EM, la enfermedad autoinmune desmielinizante del SNC más prevalente en los seres humanos.Multiple sclerosis (MS is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS. Most of autoimmune diseases arise by an abnormal activation of the inflammatory response against self-antigens (most of them unknown up to date as a consequence of dysfunction in peripheral tolerance. Regulatory T-cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory conditions. Based on that knowledge, T-regulatory cells have emerged as a key component of the physiopathology of autoimmune diseases including MS. This review compiles the current knowledge on the role and function of T-regulatory cells in MS, the most prevalent CNS autoimmune disease in humans.

  7. Incapacidad laboral en esclerosis múltiple: a propósito de un caso Working disability in multiple sclerosis: a propos of a case

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    Gian C. Navarro Chumbes

    2010-12-01

    Full Text Available Enfermera de 34 años de edad que acude a la Unidad Médica de Valoración de Incapacidades del INSS (Instituto Nacional de Seguridad Social para valoración de Incapacidad Temporal (IT; diagnosticada de Esclerosis Múltiple (EM hace 10 años, presentó 6 brotes, por lo que requirió tratamiento con Acetato de Glatirámero y se le adaptó el puesto de trabajo. Actualmente tiene un EDSS (Expanded Disability Status Scale estimado de 1,0, y actualmente no está con tratamiento inmunomodulador. Este caso clínico lo que busca es conocer de qué manera se valora la incapacidad laboral en los casos de trabajadores que padecen de EM, asimismo cómo se determina el grado de menoscabo en función del EDSS y qué aspectos laborales son tomados en consideración.A 34-year old woman, nurse, who arrives to the Medical Assessment Disability Unit of SSNI (Social Security National Institute for to assess Temporary Disability (TD, she was diagnosed of Multiple Sclerosis (MS 10 years ago, she had 6 outbreaks and because of that she was treated with Glatiramer Acetate and also her workstation was adapted. At the moment she has an EDSS (Expanded Disability Status Scale of 1.0, and now she does not receive immunomodulator treatment. With this case report we want to know the way that labour disability is evaluated for workers that complain of MS, also how the damage degree is determined according to EDSS and what labour aspects are taken into consideration.

  8. Intensive Farmaco- Surveillance of Interferon Alpha 2b Recombinant in Multiple Sclerosis. Farmacovigilancia intensiva al interferón alfa 2b recombinante en la esclerosis múltiple.

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    Hailen Bobillo López

    recombinant was safe in the treatment of the multiple sclerosis in these patients.

     

    Fundamento: El interferón alfa 2b recombinante, de producción nacional, se utiliza en el tratamiento de diferentes enfermedades, entre ellas la esclerosis múltiple. Para su comercialización se necesita conocer su margen de seguridad. Objetivo: Evaluar las reacciones adversas del interferón alfa 2b recombinante en el tratamiento de la esclerosis múltiple. Método: Durante el período comprendido entre 1996 y 2006, se revisaron las 70 historias clínicas y cuadernos de recogida de datos de los pacientes incluidos en el ensayo clínico nacional, fase IV aleatorizado, a doble ciegas, desarrollado en la Clínica de Esclerosis Múltiple del Hospital ¨Dr. Gustavo Aldereguía Lima¨ de Cienfuegos. Con respecto al total de reacciones adversas manifestadas, se analizó tipo, tiempo de duración, empleo de tratamiento o no para contrarrestarlas, grado de intensidad (leve, moderada, grave o mortal y de causalidad (definitiva, probable, posible, condicional o no relacionada. Resultados: Del total de pacientes, 53 presentaron 207 reacciones adversas al interferón. Las más frecuentes fueron: fiebre, cefalea, escalofríos, artralgia, astenia y mialgia, siendo la mayoría efectos colaterales moderados y de carácter definitivo. En 197 pacientes el desenlace fue favorable. Conclusiones: El uso del interferón alfa 2β recombinante fue seguro en el tratamiento de la esclerosis múltiple en estos pacientes.

  9. Analgesia epidural para el trabajo de parto en gestante con esclerosis múltiple Epidural analgesia during labour of a patient with multiple sclerosis

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    M.J. Mayorga Buiza; F. Caba Barrientos; F. Suárez Cordero; M. Echevarría Moreno

    2010-01-01

    La Esclerosis Múltiple (EM), es una enfermedad del SNC siendo 2 veces más frecuente su aparición en mujeres, el 70% de ellas en edad fértil. Desde el punto de vista anestésico nos encontramos ante una enfermedad con elevada susceptibilidad neurológica que podría agravarse tanto por la propia cirugía, la técnica anestésica como por la medicación utilizada. Por otra parte se plantea como atender la demanda de analgesia para el trabajo de parto en mujeres con EM, que es el grupo de edad con mayo...

  10. Descubriendo el significado de los fenómenos cronicidad, progresión y singularidad en el diagnóstico de la esclerosis múltiple Discovering the meaning of the phenomena of chronic disease, progression and singularity in the multiple sclerosis diagnosis

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    Virginia Salinas Pérez

    2012-09-01

    Full Text Available Justificación: Los pacientes asignarán un significado a fenómenos que definen la enfermedad en su vivencia ante el diagnóstico. Objetivo: Describir qué significa para los pacientes los fenómenos de cronicidad, singularidad y progresión en el diagnóstico de esclerosis múltiple. Metodología: cualitativa fenomenológica descriptiva. Muestreo intencional en 13 participantes. Se realizó entrevistas en profundidad con guión semi-estructurado y análisis de contenido según método de Taylor-Bogdan. Resultados: El fenómeno crónico desde la esperanza en la investigación y el tándem brote-recaída-degenerativo como amenaza real. Los pacientes necesitan información veraz y positiva en el diagnóstico. Conclusiones: El fenómeno crónico está relacionado con la capacidad previa de ser sano con sentimientos de tristeza e impotencia. Entienden la progresión como degeneración con miedo e incertidumbre de futuro. La esclerosis múltiple es una enfermedad desconocida en el diagnóstico y la califican de extraña o diferente para cada uno.Justification: The patients will assign a meaning and significance to define the disease in their experience about the diagnosis. Aim: Describe what it means for a person the phenomena of chronic disease, singularity and progression as a result of the multiple sclerosis diagnosis. Method: Qualitative methodology with phenomenological descriptive approach. It used intentional sampling up to thirteen participants. They were deeply interviewed with a half-organized outline and it carried out content analysis according to the Taylor-Bogdan method. Results: The chronic phenomenon in the hope in the research and the attack-relapse-degenerative tandem is a real threat. The patients need a truthful and positive information in the diagnosis. Conclusions: The chronic phenomenon is related to the previous capacity of being healthy with the feelings of sadness and impotence. They understand the progression like

  11. Esclerosis sistémica

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    Méndez Rodriguez, Alexis

    2013-01-01

    La esclerosis sistémica es una conectivopatía crónica, multisistémica, con un amplio espectro de manifestaciones clínicas y cuya morbimortalidadestá determinada por el grado de compromiso visceral. La patogenia es desconocida, pero se plantea una interacción entre factores genéticospredisponentes y desencadenantes ambientales.Su presentación clínica más frecuente es la conocida como Síndrome de CREST, acrónimo de calcinosis, fenómeno de Raynaud, trastornode motilidad esofágica, esclerodactili...

  12. Seasonal distribution and evolving forms of multiple sclerosis patients diagnosed from April 2004 to November 2007 Distribución estacional y formas evolutivas de esclerosis múltiple en pacientes diagnosticados entre Abril del 2004 y Noviembre del 2007

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    Hermes Fundora-Hernández

    2009-09-01

    Full Text Available BACKGROUND: Multiple sclerosis (MS was first reported in Cuba in 1965. The most frequent appearance is observed in the first six months of the year. OBJECTIVE: To determine the seasonal distribution and evolving forms of MS patients diagnosed with the disease between April 2004 and November 2007. METHOD: Twenty-one patients with suspected MS and 42 outbreaks were studied. Patients were classified according to Lublin and Revingold's criteria for clinical forms and according to McDonald. RESULTS: Most patients were classified in outbreak and remission and only two patients classified as primary-progressive multiple sclerosis. The higher number of outbreaks occurred in the first two quarters of the year. CONCLUSION: It is recommended to study further weather variables that may be related to the emergence of these outbreaks in our environment.INTRODUCCIÓN: La esclerosis múltiple (EM fue reportada en Cuba por primera vez en 1965. Se ha venido observando la aparición más frecuente en los primeros seis meses del año. OBJETIVO: Determinar la distribución estacional y formas evolutivas de EM en pacientes con diagnóstico de esta enfermedad entre abril 2004 y noviembre 2007. MÉTODO: Se estudiaron 21 pacientes con sospecha de EM y un total de 42 brotes. Los pacientes fueron clasificados según los criterios de Lublin y Revingold para las formas evolutivas y según los criterios de McDonald. RESULTADOS: Solo dos pacientes clasificaron en la forma evolutiva progresiva primaria; los primeros dos trimestres del año fueron los de mayor número de brotes. CONCLUSIÓN: Se recomienda profundizar en las variables climatológicas que pudieran tener vínculo con la aparición de estos brotes en nuestro medio.

  13. C3c intrathecal synthesis evaluation in patients with multiple sclerosis Evaluación de la síntesis intratecal de C3c en pacientes con esclerosis múltiple

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    Bárbara Padilla-Docal

    2007-09-01

    Full Text Available INTRODUCTION: Multiple sclerosis (MS is a chronic, inflammatory and progressive disease of the central nervous system in which local inflammatory injuries of the brain white matter appears, being the most outstanding feature the myeline loss (demyelination. OBJECTIVE: To determine if the complement system might be involved in the MS immunopathogeny favouring the mechanism intervening in the myelin destruction. METHOD: Samples of sera and CSF from twelve patients with a diagnosis of MS obtained at the moment of the admission to the hospital at the beginning of the break out, were collected. Levels of C3c and albumin in sera and in CSF were quantified using radial immunodiffusion plates. RESULTS: High values over 80% of intrathecal synthesis were obtained except in one of the patients. CONCLUSION: Intrathecal synthesis of C3c and its liberation to the CSF means that the activation of the complement system in any of the two ways has taken place, and that once performed its biological functions, has suffered a degradation process.INTRODUCCIÓN: La esclerosis múltiple (EM es una enfermedad crónica, inflamatoria y progresiva del sistema nervioso central que cursa con la aparición de lesiones inflamatorias focales en la sustancia blanca cerebral, en las que lo más llamativo es la pérdida de mielina (desmielinización. OBJETIVO: Conocer si el sistema de complemento puede estar involucrado en la inmunopatogenia de la EM favoreciendo los mecanismos que median la destrucción de la mielina. MÉTODO: Se colectaron muestras de suero y LCR de doce pacientes con diagnóstico de EM obtenidas en el momento del ingreso al inicio del brote. Se cuantificaron los niveles de C3c y albúmina en suero y en LCR en placas de inmunodifusión radial. RESULTADOS: Se obtuvieron altos valores que superan el 80% de síntesis intratecal, menos en uno de los pacientes. CONCLUSION: La síntesis intratecal de C3c y su liberación al LCR significa que ha sucedido la activaci

  14. Adverse Reactions due to the Usage Ofadverse Effects due to the Usage of T biomodulina and corticotropin in Patients Suffering from Multiple Sclerosis Efectos adversos por el uso de la biomodulina T y la corticotropina en pacientes con esclerosis múltiple

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    Idalmis Suárez Luis

    Full Text Available Background: T biomodulina is a thymic natural product with anti-inflammatory and immunomodulator action. Corticotropin is a steroid which is also used in the treatment of multiple sclerosis. Objetives: To compare the adverse effects of the biomodulina and corticotroprin in the treatment of multiple sclerosis. Methods: Phase II clinical trial, open, randomized and controlled on 17 patients suffering from multiple sclerosis to whom the following treatment was applied: group one, 100mg IV biomodulina during 10 days, 20 mg the following 20 days; group two: 1 mg of corticotroprin during 10 days followed by 0,5 mg the very next 20 days. The adverse events were evaluated from the 10th day up to the 30th day classifying its intensity as absent, mild, moderate, severe, very severe. The duration and the type of event were also classified. Results: Safeness on 8 patients treated with biomodulina and 7 patients treated with cortcotropin were assessed. 40 adverse events took place: 24 patients in whose corticotropin was used, 16 in the treatment with biomodulina (80 and 53, 3% respectively, while the moderate adverse reactions in the usage of corticotropin were more frequent. The shorter period of time of the events was produced by biomodulina. Conclusions: The usage of biomodulina was safer in the treatment of multiple sclerosis because the adverse events as well as the period of time were less intense.
    Fundamento: La biomodulina T es unproducto natural tímico con acciónantinflamatoria y acción inmunomoduladora. La corticotropina es un esteroide utilizado también en el tratamiento de la esclerosis múltiple. Objetivo: Comparar el comportamiento de efectos adversos de la biomodulina y la corticotropina en el tratamiento de la esclerosis múltiple. Métodos: Ensayo clínico fase II, abierto

  15. Esclerosis múltiple. : nuestra experiencia

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    Houlne, M.; Zalazar, M.; Sagaz, A.; López Laur, José Daniel

    2006-01-01

    Objetivos: analizar la experiencia obtenida y evaluar los resultados urodinámicos del estudio de 18 pacientes con esclerosis múltiple. Material y Métodos: se estudiaron 18 casos, valorándose la historia clínica, ecografía vesical y renal, analizándolos urodinámicamente con uroflujometría, residuo post miccional (RPM), cistotonometría y electromiografía esfinteriana. Urocultivo y antibiograma de orina. Resultados: del análisis de toda...

  16. Inmunopatología de la esclerosis múltiple

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    Francisco J Quintana

    2014-10-01

    Full Text Available La esclerosis múltiple es una enfermedad inflamatoria desmielinizante que afecta el sistema nervioso central y que es considerada una de las principales causas de discapacidad en jóvenes adultos. Las causas de la esclerosis múltiple son aún desconocidas, aunque se cree que una combinación de factores genéticos y ambientales resulta en una respuesta autoinmune que promueve la degeneración neuronal/axonal. En esta revisión se analiza la asociación entre la respuesta inmune y la neurodegeneración en la esclerosis múltiple.

  17. Calcinosis en Esclerosis Sistémica

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    Tamara Caínzos Romero; Sabela Sánchez Trigo

    2014-01-01

    Paciente de 85 años diagnosticada de esclerosis sistémica con esclerodermia limitada de años de evolución con ANA positivos a título de 1:5120 patrón anticentrómero, antiScl-70 y anti-Jo negativos. Sus principales manifestaciones clínicas son: Raynaud grave y úlceras digitales a tratamiento con nifedipino y bosentán, hipertensión pulmonar leve, esclerodactilia y calcificación extensa de tejidos blandos en ambas manos, 4º dedo de mano derecha y 4º-5º dedos de mano izquierda, con deformidades ...

  18. Anestesia subaracnóidea para cesariana em paciente portadora de esclerose múltipla: relato de caso Anestesia subaracnoidea para cesárea en paciente portadora de esclerosis múltiple: relato de caso Subarachnoid anesthesia for cesarean section in a patient with multiple sclerosis: case report

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    Fabiano Timbó Barbosa

    2007-06-01

    ón de cesárea. Después de la monitorización se realizó anestesia subaracnoidea con bupivacaína a 0,5% hiperbara (12,5 mg asociada a la morfina (0,1 mg. El procedimiento evolucionó sin interferencias y la paciente recibió su alta hospitalaria 48 horas después del parto sin empeoramiento de los síntomas preexistentes. CONCLUSIONES: El presente caso nos sugiere que la anestesia raquidea puede ser administrada en paciente portador de esclerosis múltiple sin la incidencia obligatoria de exacerbaciones agudas de los síntomas en el período postoperatorio.BACKGROUND AND OBJECTIVES: Multiple sclerosis is an acquired disease characterized by demyelinated areas in the brain and spinal cord. The clinical presentation depends on the anatomical areas involved. The main causes of death are infection, respiratory failure, and status epilepticus. It affects genetically predisposed patients after contact with environmental factors, especially viruses. The objective of this report was to present the anesthetic technique used in a patient with multiple sclerosis undergoing cesarean section. CASE REPORT: A 32-year old patient, 60 kg, with multiple sclerosis, treated with methylprednisolone, was admitted to the obstetric ward for a cesarean section. After monitoring, subarachnoid anesthesia was performed with 0.5% hyperbaric bupivacaine (12.5 mg associated with morphine (0.1 mg. The procedure evolved without any intercurrences and the patient was discharged from the hospital 48 hours after delivery without worsening of her symptoms. CONCLUSIONS: This case suggests that spinal anesthesia can be administered in patients with multiple sclerosis without the acute worsening of their symptoms in the postoperative period.

  19. Calcinosis en Esclerosis Sistémica

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    Tamara Caínzos Romero

    2014-12-01

    Full Text Available Paciente de 85 años diagnosticada de esclerosis sistémica con esclerodermia limitada de años de evolución con ANA positivos a título de 1:5120 patrón anticentrómero, antiScl-70 y anti-Jo negativos. Sus principales manifestaciones clínicas son: Raynaud grave y úlceras digitales a tratamiento con nifedipino y bosentán, hipertensión pulmonar leve, esclerodactilia y calcificación extensa de tejidos blandos en ambas manos, 4º dedo de mano derecha y 4º-5º dedos de mano izquierda, con deformidades en flexión bilaterales, que pueden observarse en estudios de radiografía simple de ambas manos. La calcinosis resulta del depósito de cristales de hidroxiapatita de calcio fundamentalmente. Aunque los resultados son, en general malos, se han utilizado diltiazem, colchicina y los AINES en los casos que se produce una reacción inflamatoria similar a la pseudogota, en los casos más graves es necesario recurrir a la cirugía.

  20. Las variables meteorológicas no explican el gradiente norte-sur en la mortalidad por esclerosis múltiple en España Meteorological variables do not explain the North-South gradient in mortality from multiple sclerosis in Spain

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    Dolores Prieto-Salceda

    2007-08-01

    Full Text Available Objetivo: Comprobar si las variables meteorológicas justifican el gradiente norte-sur en la mortalidad por esclerosis múltiple (EM en España. Métodos: La tasa de mortalidad por EM ajustada por edad en cada provincia de 1975 a 1998 se correlacionó con la media anual de diferentes variables meteorológicas. Resultados: Las temperaturas mínima, media y máxima, el número medio de horas de sol y el número de días soleados se correlacionaron negativamente con la mortalidad por EM, mientras que la cantidad de lluvia se correlacionó positivamente con la EM. La mayor parte de las correlaciones desaparecen al ajustar por latitud. En cambio, la mortalidad por EM está asociada con la latitud incluso después de ajustar por los factores meteorológicos. Conclusión: El gradiente norte-sur en la mortalidad por EM en España no puede explicarse completamente por factores meteorológicos. Son necesarias otras hipótesis para justicar esta asociación.Objectives: To determine whether weather conditions explain the North-South gradient in multiple sclerosis (MS mortality described in Spain. Methods: The age-adjusted MS mortality rate by Spanish provinces from 1975 to 1998 was correlated with several climatic variables. Results: MS mortality was negatively correlated with minimum, average and maximum temperatures, the mean number of hours of sunshine, and the mean number of sunny days. A positive correlation was found with the average amount of rain. Most correlations disappeared after adjusting by latitude. However, MS mortality was associated with latitude after adjusting by climatic factors. Conclusions: The North-South gradient in MS mortality in Spain cannot be fully explained by weather differences. Therefore, other hypotheses are required to explain this association.

  1. Is tumor necrosis factor - 376a promoter polymorphism associated with susceptibility to multiple sclerosis? ¿El polimorfismo-376A del promotor del gen del factor de necrosis tumoral se asocia con una mayor susceptibilidad a padecer esclerosis múltiple?

    Directory of Open Access Journals (Sweden)

    Marcelo A. Kauffman

    2007-10-01

    Full Text Available A single nucleotide polymorphism (SNP at position -376 of the tumor necrosis factor á gene (TNFA has been associated with susceptibility to multiple sclerosis (MS in Spain. However, no association was found in populations from the USA and The Netherlands. Here we investigate the association between the TNFA - 376A SNP and MS susceptibility in Argentinean patients with MS. The A/G genotype was found in 4.4% of patients (n=90 and in 4.8% of healthy individuals (n=84; p=0.92; odds ratio=0.93; confidence interval: 0.23- 3.84. Thus, no significant differences in genotype and allele frequencies were found between healthy individuals and patients with MS in Argentina.Un polimorfismo de nucleótido único (SNP, por sus iniciales en inglés en la posición -376 del gen codificante del factor de necrosis tumoral á (TNFA ha sido asociado en España con un mayor riesgo a padecer esclerosis múltiple (EM. Sin embargo, esta asociación no fue encontrada en estudios hechos en poblaciones provenientes de los EE.UU. y Holanda. Aquí investigamos la asociación entre el SNP TNFA -376A y el desarrollo de EM en una población de pacientes argentinos con EM. El genotipo A/G fue encontrado en 4.4% de los pacientes (n=90 y en 4.8% de los controles sanos (n=84; p=0.92; odds ratio=0.93; intervalo de confianza: 0.23-3.84. En consecuencia, no encontramos diferencias en las frecuencias alélicas y genotípicas entre los sujetos enfermos y los controles sanos en Argentina.

  2. Esclerosis tuberosa y manifestaciones orales. Caso clínico

    OpenAIRE

    López López, José; Rodríguez de Rivera Campillo, Ma Eugenia; Marques Soares, Maria Sueli; Finestres Zubeldia, Fernando; Chimenos Küstner, Eduardo; Roselló Llabrés, Xavier

    2004-01-01

    La esclerosis tuberosa (ET) es una anomalía congénita del desarrollo embrionario que se transmite de forma autosómica dominante y tiene diferentes formas de expresión clínica. Se clasifica dentro de las denominadas facomatosis (phakos "mancha" y oma "tumor"), que son anomalías del desarrollo, susceptibles de originar tumores y/o hamartomas del sistema nervioso. Es importante destacar que las lesiones del sistema nervioso se acompañan, prácticamente siempre, de anomalías cutáneas. En este trab...

  3. La esclerosis múltiple en el embarazo

    OpenAIRE

    Mieres Negro, Elena

    2016-01-01

    La esclerosis múltiple es una enfermedad autoinmune, neurodegenerativa, crónica y de causa desconocida, que cursa en forma de brotes en los que se produce la desmielinización de los axones del Sistema Nervioso Central (SNC). A estas reagudizaciones le siguen periodos de remisión de distinta duración dependiendo del patrón de progresión. El pronóstico de esta patología difiere en cada individuo al ser una enfermedad autoinmune. Sin embargo, las secuelas de estos brotes están ...

  4. Neuropsicología de la Esclerosis Múltiple

    OpenAIRE

    Mula, María

    2014-01-01

    Este estudio es una revisión amplia sobre los diferentes campos que integra la Esclerosis Múltiple con el fin de recopilar datos sobre el funcionamiento neuropsicológico de la enfermedad. Desarrollo. Las funciones neuropsicológicas más frecuentemente afectadas son la atención, la velocidad de procesamiento, la memoria de trabajo, la memoria verbal y visuoespacial, así como las funciones ejecutivas. A lo largo del tiempo se han ido creando varias baterías desarrolladas para valorar este deteri...

  5. Perfil descritivo de esclerose múltipla com início até os 16 anos nos pacientes de um centro de referência do estado de São Paulo Perfil descriptivo de esclerosis múltiple con inicio hasta los 16 años de edad en los pacientes del centro de referencia del litoral de la provincia de São Paulo Descriptive profile of multiple sclerosis starting until the age of 16 in the reference center of the state of São Paulo

    Directory of Open Access Journals (Sweden)

    Yára Dadalti Fragoso

    2012-12-01

    Full Text Available OBJETIVO: Descrever o perfil de pacientes com esclerose múltipla iniciada até os 16 anos de idade no litoral do estado de São Paulo, Brasil. DESCRIÇÃO DOS CASOS: Análise retrospectiva das características dos pacientes que tiveram o episódio inicial de esclerose múltipla até os 16 anos. Nesta situação encontravam-se nove meninas e quatro meninos (7,1% da população total de esclerose múltipla da região. A idade média por ocasião do diagnóstico foi de 13,9 anos (variação entre 8 e 16, sendo a média atual de 19,5 anos (12 a 28. A apresentação inicial da doença foi: ataxia (quatro casos, neurite óptica (dois, motora cortical (dois, sensitiva cortical (dois, distonia (dois e esclerose múltipla medular (um. Todos os pacientes iniciaram com a forma remitente-recorrente da esclerose múltipla e dois deles, atualmente, apresentam a forma progressiva secundária. COMENTÁRIOS: A esclerose múltipla com início até os 16 anos precisa ser adequadamente registrada e discutida entre pediatras, neurologistas e neuropediatras. Poucos médicos têm bom conhecimento desta condição e a demora no diagnóstico e no tratamento pode ter consequências devastadoras para essas crianças e adolescentes.OBJETIVO: Describir el perfil de los pacientes con esclerosis múltiple iniciada hasta los 16 años de edad, en la región del litoral de la provincia de São Paulo, Brasil. DESCRIPCIÓN DE LOS CASOS: Análisis retrospectivo, a partir de los registros médicos, de las características de los pacientes que tuvieron episodio inicial de esclerosis multiple hasta los 16 años de edad. Fueron nueve muchachas y cuatro muchachos en esta situación (7,1% de la población total de esclerosis multiple en la región. El promedio de edad en el momento del diagnóstico fue de 13,9 años (variación 8-16, siendo el promedio de edad actual de 19,5 años (12-28. La presentación inicial de la enfermedad fue ataxia (4 casos, neuritis óptica (2 casos, motora

  6. Efeito da equoterapia na estabilidade postural de portadores de esclerose múltipla: estudo preliminar Efecto de la hipoterapia en la estabilidad postural de portadores de esclerosis múltiple: estudio preliminar Effect of hippotherapy on the postural stability of patients with multiple sclerosis: a preliminary study

    Directory of Open Access Journals (Sweden)

    Karla Mendonça Menezes

    2013-03-01

    Full Text Available OBJETIVO: Este estudo se propôs a verificar se a estimulação por meio da equoterapia é capaz de desencadear alterações no controle postural de portadores de esclerose múltipla (EM. MÉTODO: Fizeram parte deste estudo 11 portadores de EM divididos em Grupo Intervenção (GI e Grupo Controle (GC. O GI foi inserido num programa de hipoterapia durante 4 meses, sendo conduzidas 2 sessões semanais com duração de 50 minutos cada. A estabilidade postural foi avaliada utilizando uma plataforma de força (para calcular o deslocamento do centro de pressão (COP, durante 30 segundos, em postura ereta quasi-estática, com olhos abertos e fechados, antes e após o treinamento com equoterapia. O tratamento estatístico foi feito através do ANOVA e Post hoc de Tukey com pOBJETIVO: El objetivo de éste estudio fue identificar los efectos de la hipoterapia sobre el control postural en pacientes con esclerosis múltiple (EM. MÉTODO: Hicieron parte de este estudio 11 portadores de EM divididos en Grupo Intervención (GI y Grupo Control (GC. El GI fue insertado en un programa de hipoterapia durante cuatro meses, siendo realizadas dos sesiones semanales con duración de 50 minutos cada una. La estabilidad postural fue evaluada utilizando una plataforma de fuerza (para calcular el desplazamiento del centro de presión (COP, durante 30 segundos en postura erecta casi-estática, con ojos abiertos y cerrados, antes y después del entrenamiento con hipoterapia. El tratamiento estadístico fue realizado a través de ANOVA y Post hoc de Tukey con pOBJECTIVE: This study intended to identify the effects of hippotherapy on the postural control of multiple sclerosis (MS patients. METHODS: Eleven MS patients were separated into two groups: Intervention Group (IG and Control Group (CG. Hippotherapy consisted of two 50-minute sessions each week for four months. Postural stability was evaluated before and after hippotherapy using a force plate to calculate the center of

  7. [Brief Neuropsychological Battery for multiple sclerosis. Normative data stratified by age and educational level].

    Science.gov (United States)

    Duque, P; Oltra-Cucarella, J; Fernandez, O; Sepulcre, J; Grupo de Estudio de la Bateria Neuropsicologica Breve En la Esclerosis Multiple, Grupo de Estudio de la Bateria Neuropsicologica Breve En la Esclerosis Multiple

    2017-02-01

    Introduccion. La interpretacion del rendimiento en los tests cognitivos utilizados en la evaluacion neuropsicologica de pacientes con esclerosis multiple difiere en funcion del nivel educativo del evaluado. Objetivos. Aportar datos normativos de la bateria neuropsicologica breve (BNB) en la esclerosis multiple, estratificados por edad y nivel educativo, y demostrar la utilidad de la bateria para discriminar entre sujetos sanos y pacientes con esclerosis multiple. Sujetos y metodos. Se utilizaron los datos de 701 controles sanos de la muestra de baremacion original de la BNB en la esclerosis multiple, y se estratificaron por edad y nivel educativo mediante analisis de regresion de puntuaciones escalares. Se comparo el rendimiento del grupo control con un grupo de 112 pacientes con esclerosis multiple. Resultados. Se hallaron diferencias significativas entre los grupos en las variables de la BNB, en especial en tareas de velocidad de procesamiento, memoria de trabajo y memoria verbal. La edad y el sexo no mostraron efectos relevantes. Conclusiones. Los datos indican que la BNB en la esclerosis multiple es una herramienta sensible para identificar alteraciones cognitivas en la esclerosis multiple, con especial enfasis en las tareas de memoria de trabajo.

  8. Uniting To Introduce Multiple Intelligences Teaching Approaches.

    Science.gov (United States)

    Weber, Ellen

    1999-01-01

    In Seneca, New York, the partnership between Houghton College teachers-in-training and Cuba-Rushford students and faculty has yielded unprecedented benefits. The high school proposed a guideline for integrative projects in humanities and science; the college contributed multiple intelligences teaching approaches (MITA) activities to achieve these…

  9. Esclerosis sistémica complicada con síncope y bloqueo AV completo

    OpenAIRE

    Francisco Femenía; Mauricio Arce; Martín Arrieta

    2010-01-01

    La esclerosis sistémica es una compleja enfermedad que afecta el tejido conectivo, el sistema vascular y el sistema inmunológico, y se caracteriza por fibrosis cutánea y de órganos viscerales. Los bloqueos de rama y los hemibloqueos se presentan en el 25 a 75% de los casos y constituyen predictores independientes de mortalidad. Los bloqueos auriculoventriculares de segundo o tercer grado son muy raros. Presentamos el caso de una mujer de 47 años de edad, con diagnóstico de esclerosis sistémic...

  10. Factores de riesgo en el inicio y desarrollo de la Esclerosis Múltiple

    OpenAIRE

    Antolín Lobo, Irene

    2015-01-01

    La Esclerosis Múltiple es una enfermedad inflamatoria desmielinizante crónica, de etiología desconocida, caracterizada por el ataque del propio sistema inmunitario al Sistema Nervioso Central. Esta revisión bibliográfica descriptiva, se centra en el estudio de diferentes variables que actúan como factores de riesgo influyentes en el inicio y desarrollo de la enfermedad. Se decidió realizar esta investigación, por ser la Esclerosis Múltiple una de las principales causas de disca...

  11. Caracterización nutricional y de calidad de vida en pacientes de esclerosis múltiple

    OpenAIRE

    Nieto Guindo, Pablo

    2014-01-01

    Objetivos: Caracterizar el estado nutricional y la calidad de vida en pacientes de Esclerosis Múltiple (EM), y su relación con el grado de discapacidad física. Material y Métodos: Se realizó un estudio de tipo descriptivo y transversal, en el que se incluyeron 31 pacientes diagnosticados de Esclerosis Múltiple. Dichos pacientes pertenecían al Centro Integral de Enfermedades Neurológicas de la ciudad de Albacete o a la Asociación de Esclerosis Múltiple de Almería. Para la caracterizac...

  12. Fuzzy multiple linear regression: A computational approach

    Science.gov (United States)

    Juang, C. H.; Huang, X. H.; Fleming, J. W.

    1992-01-01

    This paper presents a new computational approach for performing fuzzy regression. In contrast to Bardossy's approach, the new approach, while dealing with fuzzy variables, closely follows the conventional regression technique. In this approach, treatment of fuzzy input is more 'computational' than 'symbolic.' The following sections first outline the formulation of the new approach, then deal with the implementation and computational scheme, and this is followed by examples to illustrate the new procedure.

  13. Multiple Model Approaches to Modelling and Control,

    DEFF Research Database (Denmark)

    on the ease with which prior knowledge can be incorporated. It is interesting to note that researchers in Control Theory, Neural Networks,Statistics, Artificial Intelligence and Fuzzy Logic have more or less independently developed very similar modelling methods, calling them Local ModelNetworks, Operating...... of introduction of existing knowledge, as well as the ease of model interpretation. This book attempts to outlinemuch of the common ground between the various approaches, encouraging the transfer of ideas.Recent progress in algorithms and analysis is presented, with constructive algorithms for automated model...

  14. Esclerosis sistémica complicada con síncope y bloqueo AV completo

    Directory of Open Access Journals (Sweden)

    Francisco Femenía

    2010-10-01

    Full Text Available La esclerosis sistémica es una compleja enfermedad que afecta el tejido conectivo, el sistema vascular y el sistema inmunológico, y se caracteriza por fibrosis cutánea y de órganos viscerales. Los bloqueos de rama y los hemibloqueos se presentan en el 25 a 75% de los casos y constituyen predictores independientes de mortalidad. Los bloqueos auriculoventriculares de segundo o tercer grado son muy raros. Presentamos el caso de una mujer de 47 años de edad, con diagnóstico de esclerosis sistémica, quien presenta episodio sincopal secundario a bloqueo auriculoventricular completo con necesidad de implante de marcapasos definitivo.

  15. Simplification of multiple Fourier series - An example of algorithmic approach

    Science.gov (United States)

    Ng, E. W.

    1981-01-01

    This paper describes one example of multiple Fourier series which originate from a problem of spectral analysis of time series data. The example is exercised here with an algorithmic approach which can be generalized for other series manipulation on a computer. The generalized approach is presently pursued towards applications to a variety of multiple series and towards a general purpose algorithm for computer algebra implementation.

  16. Multiple objectives application approach to waste minimization

    Institute of Scientific and Technical Information of China (English)

    张清宇

    2002-01-01

    Besides economics and controllability, waste minimization has now become an obje ctive in designing chemical processes, and usually leads to high costs of invest ment and operation. An attempt was made to minimize waste discharged from chemic al reaction processes during the design and modification process while the opera tion conditions were also optimized to meet the requirements of technology and e conomics. Multiobjectives decision nonlinear programming (NLP) was employed to o ptimize the operation conditions of a chemical reaction process and reduce waste . A modeling language package-SPEEDUP was used to simulate the process. This p aper presents a case study of the benzene production process. The flowsheet factors affecting the economics and waste generation were examined. Constraints were imposed to reduce the number of objectives and carry out optimal calculations e asily. After comparisons of all possible solutions, best-compromise approach wa s applied to meet technological requirements and minimize waste.

  17. Multiple objectives application approach to waste minimization

    Institute of Scientific and Technical Information of China (English)

    张清宇

    2002-01-01

    Besides econormics and controllability, waste minimization has now become an objective in designing chemical processes,and usually leads to high costs of investment and operation.An attempt was mede to minimize waste discharged from chemical reaction processes during the design and modification process while the operation conditions were also optimized to meet the requirements of technology and economics.Multiob-jectives decision nonlinear programming(NLP) was emplyed optimize the operation conditions of a chemical reaction process and reduce waste. A modeling package-SPEEDUP was used to simulate the process.This paper presents a case study of the benzenc production process.The flowsheer factors affecting the economics and waste generation were examined.Constraints were imposed to reduce the number of objectives and carry out optimal calculations easily.After comparisons of all possiblle solutions,best-compromise approach was applied to meet technological requirements and minimize waste.

  18. Accuracy and reaction time in recognition of facial emotions in people with multiple sclerosis.

    Science.gov (United States)

    Parada-Fernández, Pamela; Oliva-Macías, Mireia; Amayra, Imanol; López-Paz, Juan F; Lázaro, Esther; Martínez, Óscar; Jometón, Amaia; Berrocoso, Sarah; García de Salazar, Héctor; Pérez, Manuel

    2015-11-16

    Introduccion. La expresion facial emocional constituye una guia basica en la interaccion social y, por lo tanto, las alteraciones en su expresion o reconocimiento implican una limitacion importante para la comunicacion. Por otro lado, el deterioro cognitivo y la presencia de sintomas depresivos, que se encuentran comunmente en los pacientes con esclerosis multiple, no se sabe como influyen en el reconocimiento emocional. Objetivo. Considerar la evaluacion del tiempo de reaccion y precision en la respuesta de reconocimiento de expresiones faciales de las personas afectadas por esclerosis multiple y valorar las posibles variables que pueden modular el reconocimiento de emociones, como la depresion y las funciones cognitivas. Sujetos y metodos. El estudio tiene un diseño no experimental transversal con una sola medicion. La muestra esta compuesta por 85 participantes, 45 con diagnostico de esclerosis multiple y 40 sujetos control. Resultados. Los sujetos con esclerosis multiple revelaban diferencias significativas tanto en el tiempo de reaccion y la precision de respuesta en pruebas neuropsicologicas en comparacion con el grupo control. Se identificaron modelos explicativos en el reconocimiento emocional. Conclusion. Los sujetos con esclerosis multiple se enfrentan a dificultades en el reconocimiento de emociones faciales, y se observaron diferencias en la memoria, atencion, velocidad de procesamiento y sintomatologia depresiva en relacion con el grupo control.

  19. Approaches to data analysis of multiple-choice questions

    Directory of Open Access Journals (Sweden)

    Lin Ding

    2009-09-01

    Full Text Available This paper introduces five commonly used approaches to analyzing multiple-choice test data. They are classical test theory, factor analysis, cluster analysis, item response theory, and model analysis. Brief descriptions of the goals and algorithms of these approaches are provided, together with examples illustrating their applications in physics education research. We minimize mathematics, instead placing emphasis on data interpretation using these approaches.

  20. MANGO: a new approach to multiple sequence alignment.

    Science.gov (United States)

    Zhang, Zefeng; Lin, Hao; Li, Ming

    2007-01-01

    Multiple sequence alignment is a classical and challenging task for biological sequence analysis. The problem is NP-hard. The full dynamic programming takes too much time. The progressive alignment heuristics adopted by most state of the art multiple sequence alignment programs suffer from the 'once a gap, always a gap' phenomenon. Is there a radically new way to do multiple sequence alignment? This paper introduces a novel and orthogonal multiple sequence alignment method, using multiple optimized spaced seeds and new algorithms to handle these seeds efficiently. Our new algorithm processes information of all sequences as a whole, avoiding problems caused by the popular progressive approaches. Because the optimized spaced seeds are provably significantly more sensitive than the consecutive k-mers, the new approach promises to be more accurate and reliable. To validate our new approach, we have implemented MANGO: Multiple Alignment with N Gapped Oligos. Experiments were carried out on large 16S RNA benchmarks showing that MANGO compares favorably, in both accuracy and speed, against state-of-art multiple sequence alignment methods, including ClustalW 1.83, MUSCLE 3.6, MAFFT 5.861, Prob-ConsRNA 1.11, Dialign 2.2.1, DIALIGN-T 0.2.1, T-Coffee 4.85, POA 2.0 and Kalign 2.0.

  1. Multiple scattering approach to X-ray absorption spectroscopy

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    In this paper we present the state of the art of the theoretical background needed for analyzing X-ray absorption spectra in the whole energy range. The multiple-scattering (MS) theory is presented in detail with some applications on real systems. We also describe recent progress in performing geometrical fitting of the XANES (X-ray absorption near-edge structure) energy region and beyond using a full multiple-scattering approach.

  2. Heuristic Solution Approaches to the Double TSP with Multiple Stacks

    DEFF Research Database (Denmark)

    Petersen, Hanne Løhmann

    2006-01-01

    This paper introduces the Double Travelling Salesman Problem with Multiple Stacks and presents a three different metaheuristic approaches to its solution. The Double Travelling Salesman Problem with Multiple Stacks is concerned with finding the shortest route performing pickups and deliveries...... are developed for the problem and used with each of the heuristics. Finally some computational results are given along with lower bounds on the objective value....

  3. Heuristic Solution Approaches to the Double TSP with Multiple Stacks

    DEFF Research Database (Denmark)

    Petersen, Hanne Løhmann

    This paper introduces the Double Travelling Salesman Problem with Multiple Stacks and presents a three different metaheuristic approaches to its solution. The Double Travelling Salesman Problem with Multiple Stacks is concerned with finding the shortest route performing pickups and deliveries...... are developed for the problem and used with each of the heuristics. Finally some computational results are given along with lower bounds on the objective value....

  4. Hadronic and elementary multiplicity distributions in a geometrical approach

    CERN Document Server

    Valin, P; Menon, M J

    2000-01-01

    We construct the hadronic multiplicity distribution in terms of an elementary distribution (at given impact parameter) and the inelastic overlap function characterized by the observed BEL (Blacker-Edgier-Larger) behaviour. With suitable parametrizations for the elementary quantities, based on some geometrical arguments and the most recent data on e+e- annihilation, an excellent description of pp and p(bar)p inelastic multiplicity distributions at the highest energies is obtained. With this approach, we quantitatively correlate the violations of scalings in multiplicity distributions (Koba-Nielsen-Olesen) and elastic scattering (Geometrical) at high energies.

  5. Esclerosis Múltiple en Pacientes Pediátricos: Fisiopatología, Diagnóstico y Manejo

    OpenAIRE

    Oscar Mauricio Espitia Segura; Juan David Farfán Albarracín

    2011-01-01

    Objetivo: Revisar la literatura disponible sobre esclerosis múltiple en la población pediátrica.Métodos: Revisión sistemática de la literatura encontrada en las bases de datos Scopus y PubMed posterior al año 2000.Resultados y Conclusiones: La Esclerosis Múltiple es una enfermedad con una tasa de incidencia de 2 – 4 / 100.000 habitantes en Colombia, de la cual la población pediátrica representa entre 2,7 – 5% de los casos. Las causas que se han atribuido a la enfermedad son múltiples, incluye...

  6. Apoptosis linfocitaria y efecto inmunomodulador de interferón beta en la esclerosis múltiple

    OpenAIRE

    Barcenilla Rodríguez, Hugo

    2013-01-01

    La esclerosis múltiple es una enfermedad crónica desmielinizante caracterizada por la presencia de células inflamatorias en el sistema nervioso central. Aunque su causa primara todavía se desconoce, hay evidencias de que los linfocitos T y B tienen un papel patogénico en el desarrollo de la enfermedad. Se ha demostrado la eficacia del interferón beta (IFN[beta]) en el tratamiento de la esclerosis múltiple pero su mecanismo de acción continúa siendo una incógnita. Existen pocos estudios que ev...

  7. Tratamiento del equilibrio en pacientes con esclerosis múltiple: una revisión sistemática

    OpenAIRE

    Benavides Ramiro, Ana

    2014-01-01

    RESUMEN: Introducción: la alteración en el equilibrio es una de las causas que generan mayor discapacidad en los pacientes con esclerosis múltiple, lo que hace necesario el conocimiento de las diferentes técnicas de tratamiento existentes para paliarlo. Objetivo: revisar la literatura que estudia la efectividad de las diferentes técnicas más utilizadas y valorar los efectos producidos en el equilibrio de los pacientes con esclerosis múltiple. Material y métodos: se realizó una búsqueda biblio...

  8. A Multiple Regression Approach to Normalization of Spatiotemporal Gait Features.

    Science.gov (United States)

    Wahid, Ferdous; Begg, Rezaul; Lythgo, Noel; Hass, Chris J; Halgamuge, Saman; Ackland, David C

    2016-04-01

    Normalization of gait data is performed to reduce the effects of intersubject variations due to physical characteristics. This study reports a multiple regression normalization approach for spatiotemporal gait data that takes into account intersubject variations in self-selected walking speed and physical properties including age, height, body mass, and sex. Spatiotemporal gait data including stride length, cadence, stance time, double support time, and stride time were obtained from healthy subjects including 782 children, 71 adults, 29 elderly subjects, and 28 elderly Parkinson's disease (PD) patients. Data were normalized using standard dimensionless equations, a detrending method, and a multiple regression approach. After normalization using dimensionless equations and the detrending method, weak to moderate correlations between walking speed, physical properties, and spatiotemporal gait features were observed (0.01 normalization using the multiple regression method reduced these correlations to weak values (|r| normalization using dimensionless equations and detrending resulted in significant differences in stride length and double support time of PD patients; however the multiple regression approach revealed significant differences in these features as well as in cadence, stance time, and stride time. The proposed multiple regression normalization may be useful in machine learning, gait classification, and clinical evaluation of pathological gait patterns.

  9. Esclerosis múltiple, calidad de vida y atención sociosanitaria

    Directory of Open Access Journals (Sweden)

    José Carrón

    2013-12-01

    Full Text Available La esclerosis múltiple es una enfermedad neurodegenerativa. Se caracteriza por presentar una gran variabilidad de síntomas y por evolucionar en forma de crisis o brotes. Históricamente se han observado divergencias en los datos sobre su prevalencia. Según los datos manejados en este estudio, puede afirmarse que la prevalencia se da, al menos, en 78 casos por cada 100.000 habitantes para Navarra, y que alcanza los 144 casos en el conjunto del Estado español. Esas cifras revelan que los datos utilizados tradicionalmente estaban notablemente por debajo de las cifras reales. En la actualidad no existe ninguna respuesta curativa para la esclerosis múltiple, pero sí opciones terapéuticas paliativas que alivian su cronicidad. En ese sentido, y como en todas las enfermedades crónicas, la mejora de la calidad de vida es hoy en día una cuestión de máxima importancia. La investigación nos muestra mejoras significativas principalmente en aspectos médico-sanitarios, pero también revela debilidades en otras áreas relacionadas con la autonomía y la movilidad de las personas afectadas, con su inserción en el ámbito laboral, con sus relaciones sociales, con la necesidad de mejorar el apoyo a su entorno familiar o con la imagen social. En la esclerosis múltiple emergen de manera simultánea necesidades sociales y sanitarias. En ese sentido, todo avance en el desarrollo de la atención sociosanitaria será positivo para las personas afectadas y para su entorno.

  10. Ocurrencia simultánea de neurofibromatosis y esclerosis tuberosa, adquiridas como neomutaciones

    OpenAIRE

    Janeiro, P; Cunha, M.; Cordeiro, I; Santos, H.; Antunes, N

    2008-01-01

    Introducción. La neurofibromatosis tipo 1 y la esclerosis tuberosa son dos síndromes neurocutáneos distintos, resultado de la mutación de genes supresores tumorales, que aumentan la propensión a la génesis tumoral. Ambas tienen una herencia autosómica dominante y la mitad de los casos corresponden a nuevas mutaciones. Estas enfermedades raramente se presentan asociadas. Caso clínico. Niño sin antecedentes familiares de enfermedades neurocutáneas, que presenta características de neurofibrom...

  11. Tratamiento conductual de la esclerosis lateral amiotrófica avanzada: reporte de un caso

    OpenAIRE

    Landa Ramírez, Edgar; Universidad Nacional Autónoma de México; Juárez Loya, Angélica; Universidad Nacional Autónoma de México

    2013-01-01

    El objetivo del presente estudio fue desarrollar una intervención conductual para modificar las principales necesidades reportadas por un paciente con esclerosis lateral amiotrófica en etapa avanzada con hospitalización prolongada. Se realizó una evaluación de las capacidades biológicas y psicológicas todavía presentes en el paciente y se identificaron las siguientes necesidades: comunicación con el personal de salud, uso de distractores durante la estancia hospitalaria y mejoría de la relaci...

  12. Esclerosis múltiple: a propósito de un caso

    OpenAIRE

    Franquis González, Juan Heriberto; Sierra Ojeda, Sonia; Espinosa Mondaza, Carlos

    2011-01-01

    La esclerosis múltiple es una patología, inflamatoría, autoinmune, desmielinizante y crónica que afecta al sistema nervioso central. Este daño en la mielina se traduce en un mal funcionamiento de las fibras nerviosas. Se ha presentado en individuos genéticamente susceptibles e involucra factores inmunológicos y mediadores de la respuesta inmune así como la posibilidad de relación con factores ambientales y agentes virales. Se caracteriza por ataques recurrentes multifocales de signos y síntom...

  13. Premisas de la tautología autoinmune en la esclerosis múltiple

    OpenAIRE

    Díaz Cortes, Diana Vanessa; Rodríguez Rodríguez, Alberto

    2012-01-01

    La esclerosis múltiple (EM) es una enfermedad desmielinizante del sistema nervioso central. Varias características de la EM son comunes a muchas enfermedades autoinmunes, como la mayor prevalencia en las mujeres (razón mujer:hombre 3:1), mecanismos fisiopatológicos comunes, heterogeneidad clínica, factores ambientales, herencia poligénica moderada, susceptibilidad génica, co-ocurrencia de diferentes enfermedades autoinmunes en un individuo y en los miembros de la familia, y respuesta a la ter...

  14. Esclerosis Múltiple. Manifestaciones clínicas, diagnóstico, tratamiento y estudio poblacional

    OpenAIRE

    Moreno Moya, Leticia

    2016-01-01

    La esclerosis múltiple forma parte del grupo de las enfermedades desmielinizantes inflamatorias idiopáticas. Es una enfermedad autoinmune crónica que afecta al SNC. Se caracteriza por inflamación, desmielinización y pérdida neuronal seguida de gliosis reactiva. La teoría más aceptada sobre su origen indica un factor ambiental desconocido que induce una respuesta inmune en personas genéticamente predispuestas produciendo la enfermedad. Debido a la desmielinización que se produce en esta enf...

  15. Afectación retiniana en un modelo murino experimental de esclerosis múltiple

    OpenAIRE

    Jiménez Casares, Sandra

    2015-01-01

    La esclerosis múltiple (EM) es una enfermedad neurodegenerativa autoinmune adquirida, caracterizada por un proceso crónico de desmielinización inflamatoria que afecta de forma específica al sistema nervioso central (SNC) [1-6]. Es mediada por el ataque del sistema inmune a través de células T, contra antígenos del SNC. Hay destrucción o daño de la vaina de mielina (desmielinización), pérdida de oligodendrocitos y neuronas lo que lleva al aumento de la disfuncionalidad neurológica. Con el obje...

  16. Esclerosis múltiple en España: realidad, necesidades sociales y calidad de vida

    OpenAIRE

    Federación Española de Lucha contra la Esclerosis Múltiple (FELEM)

    2007-01-01

    Se calcula que en España hay alrededor de 40.000 pacientes de esclerosis múltiple, una enfermedad de difícil diagnóstico y que puede llegar a ser muy discapacitante. Con el fin de conocer mejor a este colectivo y de sensibilizar a la población general sobre esta dolencia, el Ministerio de Trabajo y Asuntos Sociales ha encargado el presente estudio. En él se han empleado técnicas cuantitativas y cualitativas para recoger información de cuatro agentes sociales implicados en este trastorno: las ...

  17. Informe del Estudio. Actividad Física y Deporte en Esclerosis Múltiple

    OpenAIRE

    Esclerosis Múltiple España

    2015-01-01

    Tradicionalmente, el ejercicio como parte del abordaje de la Esclerosis Múltiple ha sido infrautilizado y objeto de controversia. A menudo, los médicos recomendaban que se evitara realizar ejercicio físico a las personas con esta enfermedad, debido sobre todo al incremento de la temperatura corporal asociada al deporte y vinculada a su vez con el empeoramiento de síntomas asociados a la enfermedad (discapacidad visual y paresis), así como a la fatiga, otro de los síntomas más comunes y discap...

  18. Ejercicio físico en pacientes con esclerosis múltiple

    OpenAIRE

    Etxebeste Díez, Ane

    2013-01-01

    La esclerosis múltiple (EM) es la principal causa de incapacidad neurológica en adultos jóvenes y de mediana edad. Es una enfermedad desmielinizante del Sistema Nervioso Central (SNC), cuya evolución es impredecible y sus efectos y síntomas son muy variados. Su principal observación anatomopatológica es la destrucción inmunitaria de la mielina. La fatiga es un síntoma muy común en estos pacientes, lo cual ha provocado durante muchos años que éstos fueran personas inactivas. Objetivos: E...

  19. Collaborative product and process model: Multiple Viewpoints approach

    CERN Document Server

    Geryville, Hichem; Ouzrout, Yacine; Sapidis, Nikolaos

    2007-01-01

    The design and development of complex products invariably involves many actors who have different points of view on the problem they are addressing, the product being developed, and the process by which it is being developed. The actors' viewpoints approach was designed to provide an organisational framework in which these different perspectives or points of views, and their relationships, could be explicitly gathered and formatted (by actor activity's focus). The approach acknowledges the inevitability of multiple interpretation of product information as different views, promotes gathering of actors' interests, and encourages retrieved adequate information while providing support for integration through PLM and/or SCM collaboration. In this paper, we present our multiple viewpoints approach, and we illustrate it by an industrial example on cyclone vessel product.

  20. A Multiple Model Approach to Modeling Based on LPF Algorithm

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Input-output data fitting methods are often used for unknown-structure nonlinear system modeling. Based on model-on-demand tactics, a multiple model approach to modeling for nonlinear systems is presented. The basic idea is to find out, from vast historical system input-output data sets, some data sets matching with the current working point, then to develop a local model using Local Polynomial Fitting (LPF) algorithm. With the change of working points, multiple local models are built, which realize the exact modeling for the global system. By comparing to other methods, the simulation results show good performance for its simple, effective and reliable estimation.``

  1. Departures from optimality when pursuing multiple approach or avoidance goals.

    Science.gov (United States)

    Ballard, Timothy; Yeo, Gillian; Neal, Andrew; Farrell, Simon

    2016-07-01

    This article examines how people depart from optimality during multiple-goal pursuit. The authors operationalized optimality using dynamic programming, which is a mathematical model used to calculate expected value in multistage decisions. Drawing on prospect theory, they predicted that people are risk-averse when pursuing approach goals and are therefore more likely to prioritize the goal in the best position than the dynamic programming model suggests is optimal. The authors predicted that people are risk-seeking when pursuing avoidance goals and are therefore more likely to prioritize the goal in the worst position than is optimal. These predictions were supported by results from an experimental paradigm in which participants made a series of prioritization decisions while pursuing either 2 approach or 2 avoidance goals. This research demonstrates the usefulness of using decision-making theories and normative models to understand multiple-goal pursuit. (PsycINFO Database Record

  2. A Distributed Hunting Approach for Multiple Autonomous Robots

    Directory of Open Access Journals (Sweden)

    Zhiqiang Cao

    2013-04-01

    Full Text Available A novel distributed hunting approach for multiple autonomous robots in unstructured mode‐free environments, which is based on effective sectors and local sensing, is proposed in this paper. The visual information, encoder and sonar data are integrated in the robot’s local frame, and the effective sector is introduced. The hunting task is modelled as three states: search state, round‐obstacle state, and hunting state, and the corresponding switching conditions and control strategies are given. A form of cooperation will emerge where the robots interact only locally with each other. The evader, whose motion is a priori unknown to the robots, adopts an escape strategy to avoid being captured. The approach is scalable and may cope with problems of communication and wheel slippage. The effectiveness of the proposed approach is verified through experiments with a team of wheeled robots.

  3. Adenopatía supraclavicular como forma de presentación de un carcinoma de cérvix asociado al complejo esclerosis tuberosa con linfangioleiomiomatosis

    OpenAIRE

    Pablo López Mato; Alfonso Varela Fariña; Elena Seco Hernández; Antonio J. Chamorro Fernández

    2013-01-01

    La linfangioleiomiomatosis es una proliferación del tejido muscular broncovascular que recientemente se ha definido como una expresión incompleta de la entidad “complejo esclerosis tuberosa”, una facomatosis a la que se asocian diversas neoplasias. Presentamos un caso de carcinoma de cérvix con metástasis supraclaviculares y cervicales, asociado a linfangioleiomiomatosis en el contexto de un “complejo esclerosis tuberosa”.

  4. Adenopatía supraclavicular como forma de presentación de un carcinoma de cérvix asociado al complejo esclerosis tuberosa con linfangioleiomiomatosis

    Directory of Open Access Journals (Sweden)

    Pablo López Mato

    2013-09-01

    Full Text Available La linfangioleiomiomatosis es una proliferación del tejido muscular broncovascular que recientemente se ha definido como una expresión incompleta de la entidad “complejo esclerosis tuberosa”, una facomatosis a la que se asocian diversas neoplasias. Presentamos un caso de carcinoma de cérvix con metástasis supraclaviculares y cervicales, asociado a linfangioleiomiomatosis en el contexto de un “complejo esclerosis tuberosa”.

  5. Canonical approach to finite density QCD with multiple precision computation

    CERN Document Server

    Fukuda, Ryutaro; Oka, Shotaro

    2015-01-01

    We calculate the baryon chemical potential ($\\mu_B$) dependence of thermodynamic observables, i.e., pressure, baryon number density and susceptibility by lattice QCD using the canonical approach. We compare the results with those by the multi parameter reweighting (MPR) method; Both methods give very consistent values in the regions where errors of the MPR are under control. The canonical method gives reliable results over $\\mu_ B/T=3$,with $T$ being temperature. Multiple precision operations play an important roll in the evaluation of canonical partition functions.

  6. Esclerosis Tuberosa asociada a Síndrome Nefrótico y falla renal aguda

    OpenAIRE

    Gabriela Santos Revilla; Kevin Schreiber Álvarez; Aníbal Manrique Acha; Luis Miguel Orellana Solís; Josué Bernardo Holguín; David Loja Oropeza

    2014-01-01

    El complejo de esclerosis tuberosa es una facomatosis, caracterizada por lesiones cutáneas, epilepsia y retardo mental; de variable afectación a: cerebro, riñones, corazón y otros órganos. De carácter autosómico dominante, existe entre un 60 a 70% de mutaciones de novo. Las lesiones renales se pueden identificar hasta en un 57.5% de pacientes.Se reporta el caso de un paciente varón de 20 años de edad en el Hospital Nacional Arzobispo Loayza. Se presentó con angiofibromas cutáneos, placas de Cha...

  7. El perfil neuropsicológico en la esclerosis múltiple

    OpenAIRE

    Arango-Lasprilla, Juan Carlos; DeLuca, John; Chiaravalloti, Nancy

    2007-01-01

    La Esclerosis Múltiple (EM) es la enfermedad neurológica no traumática más común entre personas jóvenes y adultos en etapas medias de la vida. La presente investigación tuvo como objetivo estudiar el perfil neuropsicológico de un grupo de sujetos con EM. A ochenta sujetos con diagnóstico de EM y 40 sujetos sanos se les administró una batería de evaluación neuropsicológica. El grupo de personas con EM presentó puntuaciones más bajas en todas las pruebas y, en el 84% de las variables medidas (1...

  8. Per-Sample Multiple Kernel Approach for Visual Concept Learning

    Directory of Open Access Journals (Sweden)

    Ling-Yu Duan

    2010-01-01

    Full Text Available Learning visual concepts from images is an important yet challenging problem in computer vision and multimedia research areas. Multiple kernel learning (MKL methods have shown great advantages in visual concept learning. As a visual concept often exhibits great appearance variance, a canonical MKL approach may not generate satisfactory results when a uniform kernel combination is applied over the input space. In this paper, we propose a per-sample multiple kernel learning (PS-MKL approach to take into account intraclass diversity for improving discrimination. PS-MKL determines sample-wise kernel weights according to kernel functions and training samples. Kernel weights as well as kernel-based classifiers are jointly learned. For efficient learning, PS-MKL employs a sample selection strategy. Extensive experiments are carried out over three benchmarking datasets of different characteristics including Caltech101, WikipediaMM, and Pascal VOC'07. PS-MKL has achieved encouraging performance, comparable to the state of the art, which has outperformed a canonical MKL.

  9. Per-Sample Multiple Kernel Approach for Visual Concept Learning

    Directory of Open Access Journals (Sweden)

    Tian Yonghong

    2010-01-01

    Full Text Available Abstract Learning visual concepts from images is an important yet challenging problem in computer vision and multimedia research areas. Multiple kernel learning (MKL methods have shown great advantages in visual concept learning. As a visual concept often exhibits great appearance variance, a canonical MKL approach may not generate satisfactory results when a uniform kernel combination is applied over the input space. In this paper, we propose a per-sample multiple kernel learning (PS-MKL approach to take into account intraclass diversity for improving discrimination. PS-MKL determines sample-wise kernel weights according to kernel functions and training samples. Kernel weights as well as kernel-based classifiers are jointly learned. For efficient learning, PS-MKL employs a sample selection strategy. Extensive experiments are carried out over three benchmarking datasets of different characteristics including Caltech101, WikipediaMM, and Pascal VOC'07. PS-MKL has achieved encouraging performance, comparable to the state of the art, which has outperformed a canonical MKL.

  10. A divide and conquer approach to multiple alignment.

    Science.gov (United States)

    Dress, A; Füllen, G; Perrey, S

    1995-01-01

    We present a report on work in progress on a divide and conquer approach to multiple alignment. The algorithm makes use of the costs calculated from applying the standard dynamic programming scheme to all pairs of sequences. The resulting cost matrices for pairwise alignment give rise to secondary matrices containing the additional costs imposed by fixing the path through the dynamic programming graph at a particular vertex. Such a constraint corresponds to a division of the problem obtained by slicing both sequences between two particular positions, and aligning the two sequences on the left and the two sequences on the right, charging for gaps introduced at the slicing point. To obtain an estimate for the additional cost imposed by forcing the multiple alignment through a particular vertex in the whole hypercube, we will take a (weighted) sum of secondary costs over all pairwise projections of the division of the problem, as defined by this vertex, that is, by slicing all sequences at the points suggested by the vertex. We then use that partition of every single sequence under consideration into two 'halfs' which imposes a minimal (weighted) sum of pairwise additional costs, making sure that one of the sequences is divided somewhere close to its midpoint. Hence, each iteration can cut the problem size in half. As the enumeration of all possible partitions may restrict this approach to small-size problems, we eliminate futile partitions, and organize their enumeration in a way that starts with the most promising ones.(ABSTRACT TRUNCATED AT 250 WORDS)

  11. Mapeo de la evolución de una enfermedad usando sistemas Neuro-Difusos. Caso de estudio: Esclerosis Múltiple

    Directory of Open Access Journals (Sweden)

    Héctor A. Tabares O.

    2012-06-01

    Full Text Available El presente artículo propone un modelo para estudiar la evolución de la esclerosis múltiple, enfermedad desmielinizante, neurodegenerativa y crónica del sistema nervioso central. El modelo planteado se basa en la utilización de un sistema neuro-difuso como herramienta para describir la progresión de la enfermedad, empleando un caso particular para su validación. Los datos de estudio corresponden a la historia clínica de un paciente con diagnóstico de esclerosis múltiple desde 2003, quien ha padecido cinco episodios críticos. El modelo desarrollado permitió detectar los cambios de la inflación neurológica del paciente.

  12. SOME NEUROCHEMICAL DISTURBANCES IN MULTIPLE SCLEROSIS

    Directory of Open Access Journals (Sweden)

    Vladimir V. Markelov

    2006-04-01

    Full Text Available ABSTRACTThe data presented in this manuscript suggest a pivotal role of the central nervous system (CNS in the regulation of immune status. We describe here that some neurochemical disturbances may provoke development of various diseases including multiple sclerosis. Some theoretic and practical backgrounds, how to improve the multiple sclerosis sufferers and patients with other autoimmune disorders, are also given.RESUMENLos datos que presentamos en este manuscrito, sugieren un papel guia del sistema nervioso central (SNC en la regulación del estado inmune. Describimos aquí que varias alteraciones neuroquímicas pueden provocar el desarrollo de varias enfermedades, incluyendo esclerosis múltiple. También se comenta acerca del trasfondo teórico y práctico, y cómo mejorar a víctimas y pacientes con esclerosis múltiple y otras alteraciones autoinmunes.

  13. Reserva cognitiva y déficit en la planificación en pacientes con esclerosis múltiple.

    Directory of Open Access Journals (Sweden)

    Lilia Mestas

    2012-01-01

    Full Text Available

    La esclerosis múltiple afecta el sistema nervioso produciendo alteraciones cognitivas. La memoria es uno de los más afectados, no obstante la naturaleza ó factor primario de alteración aún no se clarifica. Objetivo: Estudia las diferencias en el procesamiento de la información verbal en un grupo de pacientes con esta patologíaa neurológica respecto a un grupo de control sano. Para ello se analizó el desempeño neuropsicológico de 16 pacientes con esclerosis múltiple de tipo remitente-recurrente y un grupo de control equiparado en las variables sociodemográficas. A los dos grupos se les aplic? el Test de Aprendizaje Verbal España-Complutense, y se realizó una comparación entre diversos índices de la prueba, además de un análisis de correlaciones entre las variables socio-demográficas del grupo experimental para identificar algún factor protector. Resultados: el grupo de esclerosis múltiple obtuvo rendimientos inferiores en los índices analizados respecto al de control, además de una correlación positiva entre años de escolaridad y el inicio de la enfermedad y entre el inicio de la enfermedad y la ocupación. Los datos encontrados parecen indicar que los pacientes con esclerosis múltiple tienen poca capacidad de planificación, que incide de manera directa en su desempeño en tareas de memoria y aprendizaje.

  14. Phylo: a citizen science approach for improving multiple sequence alignment.

    Directory of Open Access Journals (Sweden)

    Alexander Kawrykow

    Full Text Available BACKGROUND: Comparative genomics, or the study of the relationships of genome structure and function across different species, offers a powerful tool for studying evolution, annotating genomes, and understanding the causes of various genetic disorders. However, aligning multiple sequences of DNA, an essential intermediate step for most types of analyses, is a difficult computational task. In parallel, citizen science, an approach that takes advantage of the fact that the human brain is exquisitely tuned to solving specific types of problems, is becoming increasingly popular. There, instances of hard computational problems are dispatched to a crowd of non-expert human game players and solutions are sent back to a central server. METHODOLOGY/PRINCIPAL FINDINGS: We introduce Phylo, a human-based computing framework applying "crowd sourcing" techniques to solve the Multiple Sequence Alignment (MSA problem. The key idea of Phylo is to convert the MSA problem into a casual game that can be played by ordinary web users with a minimal prior knowledge of the biological context. We applied this strategy to improve the alignment of the promoters of disease-related genes from up to 44 vertebrate species. Since the launch in November 2010, we received more than 350,000 solutions submitted from more than 12,000 registered users. Our results show that solutions submitted contributed to improving the accuracy of up to 70% of the alignment blocks considered. CONCLUSIONS/SIGNIFICANCE: We demonstrate that, combined with classical algorithms, crowd computing techniques can be successfully used to help improving the accuracy of MSA. More importantly, we show that an NP-hard computational problem can be embedded in casual game that can be easily played by people without significant scientific training. This suggests that citizen science approaches can be used to exploit the billions of "human-brain peta-flops" of computation that are spent every day playing games

  15. An Efficient Approach of Processing Multiple Continuous Queries

    Institute of Scientific and Technical Information of China (English)

    Wen Liu; Yan-Ming Shen; Peng Wang

    2016-01-01

    As stream data is being more frequently collected and analyzed, stream processing systems are faced with more design challenges. One challenge is to perform continuous window aggregation, which involves intensive computation. When there are a large number of aggregation queries, the system may suffer from scalability problems. The queries are usually similar and only differ in window specifications. In this paper, we propose collaborative aggregation which promotes aggregate sharing among the windows so that repeated aggregate operations can be avoided. Different from the previous approaches in which the aggregate sharing is restricted by the window pace, we generalize the aggregation over multiple values as a series of reductions. Therefore, the results generated by each reduction step can be shared. The sharing process is formalized in the feed semantics and we present the compose-and-declare framework to determine the data sharing logic at a very low cost. Experimental results show that our approach offers an order of magnitude performance improvement to the state-of-the-art results and has a small memory footprint.

  16. Multiple-linac approach for tritium production and other applications

    Energy Technology Data Exchange (ETDEWEB)

    Ruggiero, A.G.

    1995-01-10

    This report describes an approach to tritium production based on the use of multiple proton linear accelerators. Features of a single APTT Linac as proposed by the Los Alamos National Laboratory are presented and discussed. An alternative approach to the attainment of the same total proton beam power of 200 MW with several lower-performance superconducting Linacs is proposed and discussed. Although each of these accelerators are considerable extrapolations of present technology, the latter can nevertheless be built at less technical risk when compared to the single high-current APT Linac, particularly concerning the design and the performance of the low-energy front-end. The use of superconducting cavities is also proposed as a way of optimizing the accelerating gradient, the overall length, and the operational costs. The superconducting technology has already been successfully demonstrated in a number of large-size projects and should be seriously considered for the acceleration of intense low-energy beams of protons. Finally, each linear accelerator would represent an ideal source of very intense beams of protons for a variety of applications, such as: weapons and waste actinide transmutation processes, isotopes for medical application, spallation neutron sources, and the generation of intense beams of neutrinos and muons for nuclear and high-energy physics research. The research community at large has obviously an interest in providing expertise for, and in having access to, the demonstration, the construction, the operation, and the exploitation of these top-performance accelerators.

  17. [Multiple sclerosis in literature, cinema and television].

    Science.gov (United States)

    Collado-Vazquez, S; Carrillo, J M; Cano-de-la-Cuerda, R

    2016-12-16

    Introduccion. En la actualidad, la atencion del paciente con esclerosis multiple y su entorno supone un reto clinico y terapeutico para los profesionales de la salud. El objetivo del presente trabajo es analizar la aparicion de la esclerosis multiple en la literatura, el cine y la television, y reflexionar sobre su imagen en dichos medios. Desarrollo. Se han revisado algunas obras representativas que han abordado la esclerosis multiple, y se ha observado que en muchas de ellas se ofrece una vision muy fidedigna de la enfermedad. Del mismo modo, se han revisado las principales peliculas y series de television que, en ocasiones, son un reflejo cercano al publico general de la vision e impacto de la enfermedad sobre los pacientes o familiares, no exentas de excesos dramaticos y distorsiones de la realidad. Conclusiones. La literatura refleja, en gran medida, la epidemiologia real, los sintomas y la progresion de la enfermedad, mientras que las opciones diagnosticas y terapeuticas parecen estar en un segundo plano. El cine y la television han ofrecido una imagen correcta, pero en ocasiones atendiendo mas a efectos dramaticos. Es importante que la literatura, el cine y la television ofrezcan una vision ajustada a la realidad de esta enfermedad para dar a conocer esta afeccion neurologica y contribuir a disminuir su estigma.

  18. Comparing the Effect of Inquiry-Based Multiple Intelligence Approach and Non-Inquiry Based Multiple Intelligence Approach on Achievement in Science

    Directory of Open Access Journals (Sweden)

    Mohd Ali Samsudin

    2015-11-01

    Full Text Available The paper focused attention on comparing the effect of inquiry based multiple intelligence approach and non-inquiry based multiple intelligence approach on achievement of pupils in some selected primary schools. Two primary schools were selected purposively with one intact class from each school. Each intact class of thirty (30 pupils was randomly assigned to the two groups used for the study. A total of sixty (60 pupils were used in the study. The two groups were assigned each to the inquiry based multiple intelligence approach group and the non- inquiry based multiple intelligence approach group. The research design was a quasi-experimental design, involving a pretest and post-test in achievement of students. The reliability of the test instrument was established at 0.75 which was considered adequate. A pretest- was administered to the pupils .The pupils were taught science concepts based on the curriculum of the ministry of education for a period of eight (8 weeks using the inquiry- based multiple intelligence approach and non- inquiry multiple intelligence approach for group A and B respectively after which the post-test- was administered. . Findings using the statistical tools of mean, median, standard deviation the one way analysis of covariant (ANCOVA were used to proffer answers to the generated research questions and hypotheses revealed that there was significant difference between the achievement scores of pupils in science for the use of non- inquiry based multiple intelligence approach and non- inquiry based multiple intelligence approach on. It was also statistically established that the effect of inquiry based multiple intelligence approach was on achievement is science was better. Conclusion and recommendations such as introducing and enhancing the use of inquiry based multiple intelligence approach in primary and secondly schools were made.

  19. GEMSP: a new therapeutic approach to multiple sclerosis.

    Science.gov (United States)

    Geffard, Michel; Duleu, Sebastien; Bessede, Alban; Vigier, Valerie; Bodet, Dominique; Mangas, Arturo; Covenas, Rafael

    2012-09-01

    A new therapeutic approach called Endotherapia (GEMSP) for the treatment of Multiple Sclerosis (MS) is suggested. Endotherapia is the result of an immunopathological strategy addressing chronic incurable diseases with a multifactorial etiology. This approach combines a biomedical evaluation of circulating immunoglobulins directed against specific self-antigens and self-antigens modified by free radicals. GEMSP is a "tailor-made" combination of small molecules (fatty acids, antioxidants, radical scavengers, amino acids) linked to a non-immunogenic linear chain of poly-L.lysine (PLL). Each individual linkage or PLL derivative offers great advantages, such as an increase in the half-life of the active small molecules. GEMSP inhibits brain leukocyte infiltration and abolishes episodes of experimental autoimmune encephalomyelitis. In a clinical trial with 102 MS patients treated with GEMSP Endotherapia, 28% of them showed a worsening of their state; 20% showed a decrease in the progression of the disease; 17% showed disease stabilization; and 35% showed a reversal of the evolution of disease; i.e., an improvement in their disease state. In 72% of the cases, a positive evolution of the state of the MS patients treated with Endotherapia was observed (a decrease or stabilization of disease evolution or an improvement). Endotherapia is very safe and no side-effects were reported for GEMSP. Moreover, GEMSP showed no toxicity either in experimental animals or in humans. It seems that Endotherapia is a promising therapy for MS, with no side-effects, which should be considered in the management of long-term pathologies.

  20. Teaching Electric Circuits with Multiple Batteries: A Qualitative Approach

    Science.gov (United States)

    Smith, David P.; van Kampen, Paul

    2011-01-01

    We have investigated preservice science teachers' qualitative understanding of circuits consisting of multiple batteries in single and multiple loops using a pretest and post-test method and classroom observations. We found that most students were unable to explain the effects of adding batteries in single and multiple loops, as they tended to use…

  1. Isolation of Polyvalent Bacteriophages by Sequential Multiple-Host Approaches.

    Science.gov (United States)

    Yu, Pingfeng; Mathieu, Jacques; Li, Mengyan; Dai, Zhaoyi; Alvarez, Pedro J J

    2015-11-20

    Many studies on phage biology are based on isolation methods that may inadvertently select for narrow-host-range phages. Consequently, broad-host-range phages, whose ecological significance is largely unexplored, are consistently overlooked. To enhance research on such polyvalent phages, we developed two sequential multihost isolation methods and tested both culture-dependent and culture-independent phage libraries for broad infectivity. Lytic phages isolated from activated sludge were capable of interspecies or even interorder infectivity without a significant reduction in the efficiency of plating (0.45 to 1.15). Two polyvalent phages (PX1 of the Podoviridae family and PEf1 of the Siphoviridae family) were characterized in terms of adsorption rate (3.54 × 10(-10) to 8.53 × 10(-10) ml/min), latent time (40 to 55 min), and burst size (45 to 99 PFU/cell), using different hosts. These phages were enriched with a nonpathogenic host (Pseudomonas putida F1 or Escherichia coli K-12) and subsequently used to infect model problematic bacteria. By using a multiplicity of infection of 10 in bacterial challenge tests, >60% lethality was observed for Pseudomonas aeruginosa relative to uninfected controls. The corresponding lethality for Pseudomonas syringae was ∼ 50%. Overall, this work suggests that polyvalent phages may be readily isolated from the environment by using different sequential hosts, and this approach should facilitate the study of their ecological significance as well as enable novel applications.

  2. Multiple approaches to microbial source tracking in tropical northern Australia

    KAUST Repository

    Neave, Matthew

    2014-09-16

    Microbial source tracking is an area of research in which multiple approaches are used to identify the sources of elevated bacterial concentrations in recreational lakes and beaches. At our study location in Darwin, northern Australia, water quality in the harbor is generally good, however dry-season beach closures due to elevated Escherichia coli and enterococci counts are a cause for concern. The sources of these high bacteria counts are currently unknown. To address this, we sampled sewage outfalls, other potential inputs, such as urban rivers and drains, and surrounding beaches, and used genetic fingerprints from E. coli and enterococci communities, fecal markers and 454 pyrosequencing to track contamination sources. A sewage effluent outfall (Larrakeyah discharge) was a source of bacteria, including fecal bacteria that impacted nearby beaches. Two other treated effluent discharges did not appear to influence sites other than those directly adjacent. Several beaches contained fecal indicator bacteria that likely originated from urban rivers and creeks within the catchment. Generally, connectivity between the sites was observed within distinct geographical locations and it appeared that most of the bacterial contamination on Darwin beaches was confined to local sources.

  3. Management of pain in multiple sclerosis: a pharmacological approach.

    Science.gov (United States)

    Solaro, Claudio; Uccelli, Michele Messmer

    2011-08-16

    About half of patients with multiple sclerosis (MS) report pain; treatment for pain alone accounts for nearly 30% of the total use of medications for the management of all MS-related symptoms. Patients with MS can experience more than one type of pain simultaneously and at any point during the disease course, even in newly or recently diagnosed cases. Pain in MS can be associated with other symptoms, including spasticity, fatigue and mood disorder. Pain sufferers experience disruption in daily life activities, work, mood, recreation and general enjoyment of life, and report low satisfaction with pain management. Many clinical features of pain are often unrecognized by clinicians and are difficult for patients to describe. The majority of clinical evidence regarding treatment stems from small pilot and open-label studies; therefore, treatment of pain associated with MS is often based on anecdotal reports and clinicians' experience. The open-label design of the majority of studies, the unavailability of large samples and the difficulty of performing placebo-controlled studies because of ethical considerations result in insufficient evidence to support or refute the effectiveness of pain medications. This Review presents available data regarding pharmacological approaches for addressing pain in MS and highlights the shortcomings in pain management research.

  4. CURRENT APPROACHES FOR RESEARCH OF MULTIPLE SCLEROSIS BIOMARKERS

    Directory of Open Access Journals (Sweden)

    Kolyada T.I

    2016-12-01

    Full Text Available Current data concerning features of multiple sclerosis (MS etiology, pathogenesis, clinical course and treatment of disease indicate the necessity of personalized approach to the management of MS patients. These features are the variety of possible etiological factors and mechanisms that trigger the development of MS, different courses of disease, and significant differences in treatment efficiency. Phenotypic and pathogenetic heterogeneity of MS requires, on the one hand, the stratification of patients into groups with different treatment depending on a number of criteria including genetic characteristics, disease course, stage of the pathological process, and forms of the disease. On the other hand, it requires the use of modern methods for assessment of individual risk of developing MS, its early diagnosis, evaluation and prognosis of the disease course and the treatment efficiency. This approach is based on the identification and determination of biomarkers of MS including the use of systems biology technology platforms such as genomics, proteomics, metabolomics and bioinformatics. Research and practical use of biomarkers of MS in clinical and laboratory practice requires the use of a wide range of modern medical and biological, mathematical and physicochemical methods. The group of "classical" methods used to study MS biomarkers includes physicochemical and immunological methods aimed at the selection and identification of single molecular biomarkers, as well as methods of molecular genetic analysis. This group of methods includes ELISA, western blotting, isoelectric focusing, immunohistochemical methods, flow cytometry, spectrophotometric and nephelometric methods. These techniques make it possible to carry out both qualitative and quantitative assay of molecular biomarkers. The group of "classical methods" can also include methods based on polymerase chain reaction (including multiplex and allele-specific PCR and genome sequencing

  5. An Holistic Approach for Counsellors: Embracing Multiple Intelligences

    Science.gov (United States)

    Booth, Rosslyn; O'Brien, Patrick John

    2008-01-01

    This paper explores a range of therapeutic modalities used by counsellors of children and positions those modalities within Gardner's theory of multiple intelligences. Research by O'Brien ("Gardner's theory of multiple intelligence and its implications for the counselling of children." Unpublished doctoral dissertation, Queensland University of…

  6. Esclerosis sistémica complicada con síncope y bloqueo AV completo Systemic sclerosis complicated with syncope and complete AV block

    OpenAIRE

    Francisco Femenía; Mauricio Arce; Martín Arrieta

    2010-01-01

    La esclerosis sistémica es una compleja enfermedad que afecta el tejido conectivo, el sistema vascular y el sistema inmunológico, y se caracteriza por fibrosis cutánea y de órganos viscerales. Los bloqueos de rama y los hemibloqueos se presentan en el 25 a 75% de los casos y constituyen predictores independientes de mortalidad. Los bloqueos auriculoventriculares de segundo o tercer grado son muy raros. Presentamos el caso de una mujer de 47 años de edad, con diagnóstico de esclerosis sistémic...

  7. Caracterización de la esclerosis tuberosa en pacientes que consultan al Hospital Universitario San Vicente de Paúl, Medellín, Colombia

    OpenAIRE

    Dagoberto Nicanor Cabrera Hémer; Jaime Carrizosa Moog; Olga Juliana Cuéllar; Dionis Vallejo Mesa; José Vladimir Tobón Areiza; José William Cornejo Ochoa

    2008-01-01

    La esclerosis tuberosa (ET) es una enfermedad autosómica dominante, que afecta muchos sistemas y cursa con diversas manifestaciones clínicas, entre ellas epilepsia, retardo mental y lesiones cutáneas. Se hizo un estudio retrospectivo para contribuir a la caracterización de la esclerosis tuberosa en Medellín, Colombia. Se revisaron 21 historias, 62% mujeres y 38% hombres; la edad media al momento del diagnóstico fue 23 meses, todos los pacientes tenían epilepsia y lesiones cutáneas, las crisis...

  8. Influencia de la toma de anticonceptivos hormonales combinados orales en el debut y el curso clínico de la esclerosis múltiple recurrente remitente

    OpenAIRE

    Hernández Clares, Rocío

    2016-01-01

    La Esclerosis Múltiple (EM) es una enfermedad desmielinizante inflamatoria crónica del sistema nervioso central (SNC) que afecta de forma típica a personas jóvenes, alrededor de la tercera década de la vida, suponiendo la segunda causa de discapacidad neurológica a esa edad. La paradoja de que las mujeres tengan un mayor riesgo de esclerosis múltiple pero que los hombres tengan una evolución peor de la enfermedad ha ayudado a descubrir un aspecto fascinante de la fisiopatología de la EM, a...

  9. Teaching electric circuits with multiple batteries: A qualitative approach

    Directory of Open Access Journals (Sweden)

    David P. Smith*

    2011-11-01

    Full Text Available We have investigated preservice science teachers’ qualitative understanding of circuits consisting of multiple batteries in single and multiple loops using a pretest and post-test method and classroom observations. We found that most students were unable to explain the effects of adding batteries in single and multiple loops, as they tended to use reasoning based on current and resistance where reasoning based on voltage is a necessity. We also found that problems such as thinking of the battery as a source of constant current resurfaced in this new context, and that answers given were inconsistent with current conservation. We describe the curriculum we developed that enables students to model circuits with multiple batteries qualitatively. Post-test results show that the majority of students were able to apply their newly developed model to make accurate predictions for complex circuits.

  10. Hallazgos radiológicos en manos de una cohorte de pacientes colombianos con esclerosis sistémica

    OpenAIRE

    Herrera Acevedo, Julián Bernardo

    2014-01-01

    Introducción: la esclerosis sistémica (ES) es una enfermedad del tejido conectivo que se caracteriza por cambios vasculares, inmunes y Xibróticos en la piel y ciertos Órganos internos. Una de las manifestaciones mas relevantes de la enfermedad es el compromiso de los músculos y las articulaciones. Este es especialmente frecuente en las manos, de allí que las personas afectadas sufran una limitación funcional importante que impacta la calidad de vida. Se han descrito diferentes hallazgos...

  11. Fibroma desmoplásico del alvéolo maxilar asociado a esclerosis tuberosa: reporte de caso

    OpenAIRE

    Mejía Cortés, Maddy; Departamento de Patología, Hospital Universitario San Ignacio, Bogotá, Colombia. Docente del Departamento de Patología, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia.; De León Rodríguez, Oscar; Odontólogo cirujano maxilofacial, Hospital Universitario San Ignacio. Profesor de la Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia.; Peña, Claudia; Pontificia Universidad Javeriana, Bogotá, Colombia. Facultad de Odontología, Universidad Nacional de Colombia.; Paez, Jorge; Pontificia Universidad Javeriana, Bogotá, Colombia.; Solarte, Paula; Pontificia Universidad Javeriana; Bermúdez Rey, Maria Carolina; Pontificia Universidad Javeriana, Bogotá, Colombia

    2016-01-01

     La esclerosis tuberosa es un trastorno autosómico dominante que se manifiesta con la formación de hamartomas en múltiples órganos y sistemas, como el sistema nervioso central, la piel, los riñones, los pulmones y el corazón. Los pacientes se ven afectados por cuadros de convulsiones, así como por hallazgos cutáneos. En la cavidad oral, las lesiones se presentan en el esmalte dental y constituyen la presentación más frecuente, pero rara vez se encuentran lesiones en los maxilares. El fibroma ...

  12. Revisión Sistemática y Crítica de la disartria en la Esclerosis Múltiple

    OpenAIRE

    Pérez Fernández, Carolina

    2014-01-01

    Background: Esta Revisión Bibliográfica parte de diversas descripciones de casos de pacientes con Esclerosis Múltiple, recogidas en 26 artículos. Objetivo: Se pretende revisar la literatura médica disponible sobre aspectos logopédicos relacionados con la enfermedad y conocer el tratamiento asociado a esos síntomas. Metodología: Revisión Sistemática en bases de datos Pubmed y Ebscohost de estudios de casos que hagan referencia a sintomatología asociada, especialmente relac...

  13. Efectividad del tratamiento fisioterápico en el equilibrio en el paciente con esclerosis múltiple

    OpenAIRE

    Hernando Garijo, Ignacio

    2016-01-01

    La esclerosis múltiple es una enfermedad potencialmente incapacitante que afecta con gran frecuencia al equilibrio en las personas que la padecen. Este deterioro del equilibrio aumenta el riesgo de caídas, dando lugar a lesiones añadidas, incremento del gasto sanitario y aumento de la inactividad por miedo a volver a sufrir una caída. En este estudio se propone como objetivo contrastar la efectividad del tratamiento de fisioterapia sobre el equilibrio en pacientes que sufren...

  14. Caracterización de SNP de susceptibilidad en dos microRNA relacionados con la esclerosis múltiple

    OpenAIRE

    De la Cuesta Etxeberria, Maialen

    2016-01-01

    La esclerosis múltiple es una enfermedad crónica autoinmune y desmielinizante del sistema nervioso central caracterizada por las lesiones o placas escleróticas que presentan sus pacientes. Estas placas se forman como consecuencia de una desmielinización focal aguda e inflamatoria asociada a una posible pérdida axonal con una posterior remielinización.La función de estas moléculas de RNA, compuestas por 22 nucleótidos aproximadamente, es regular la expresión génica, bien degradando el mRNA,...

  15. Influencia de la movilización del plexo sacro en pacientes con esclerosis múltiple

    OpenAIRE

    Ulecia Barrios, Miriam

    2016-01-01

    INTRODUCCIÓN: La esclerosis múltiple se considera la mayor causa no traumática de discapacidad en adultos jóvenes, presentando un 80% de los pacientes espasticidad. La movilización neural, considerando el sistema nervioso como un único sistema continuo, mejora las condiciones fisiológicas del sistema. OBJETIVOS: Determinar la influencia de la movilización del plexo sacro en la fatiga, en la espasticidad, en el rango articular de la flexión de cadera y en la velocidad y segurida...

  16. Multiple Intelligences within the Cross-Curricular Approach

    Directory of Open Access Journals (Sweden)

    Anthoula Vaiou

    2010-02-01

    Full Text Available The present study was realized in a Greek 6th grade State Primary School class and was based on Howard Gardner’s theory of multiple intelligences, which was first introduced in 1983. More particularly, it was explored to what extent the young learners possess multiple intelligences through the use of a specially-designed questionnaire and a series of interviews. The findings of the above have served as a tool to the construction of a project work based on students’ learning preferences within a cross-curricular framework, easily applicable to the Greek State School curriculum. All learners were activated to participate within a school environment that traditionally promotes linguistic and mathematical skills matching dominant multiple intelligences or a combination of some of them to thematic units already taught by Greek teachers. The suggested project was assessed through observation and student portfolio, showing that the young learners’ multiple intelligences were exploited to a great extent, promoting the learning process satisfactorily. The results of this study can provide a contribution to the literature of multiple intelligences in the Greek reality and suggest a need for further consideration and exploration in the field. Finally, the researcher of this study hopes the present work could function as a springboard for more elaborated studies in the future.

  17. Esclerosis lateral amiotrofica; complicaciones gastrointestinales en nutrición enteral domiciliaria

    Directory of Open Access Journals (Sweden)

    R. Ramírez Puerta

    2013-12-01

    Full Text Available Objetivos: Analizar las complicaciones relacionadas con el soporte nutricional enteral en los pacientes con esclerosis lateral amiotrófica que forman parte de nuestro programa de ventilación mecánica domiciliaria, haciendo especial hincapié en las gastrointestinales. Método: Estudio retrospectivo de tipo descriptivo de enfermos que se incluyeron en nuestro Programa de Ventilación Mecánica Domiciliaria (PVMD dirigido por médicos intensivistas, mediante la revisión sistemática de historias clínicas (procedentes de una base de datos de Microsoft Access, durante los años 2004-2011. Resultados: Entre los años 2004-2011 se siguieron 73 pacientes con diagnostico de Esclerosis lateral amiotrófica: 34 de ellos (46,6% rechazaron el aporte nutricional a través de gastrostomía o de sonda nasogástrica, mientras que 39 (53,4% aceptaron su colocación. De los 39 pacientes en los que se inició la NED: 20 eran mujeres mujeres (51,3%. La edad media de los pacienes fue de 60,6 + 13,4 años (IC 95% 56,464,8. Los diagnósticos al ingreso en el PVMD fueron: ELA, 21 casos (53,8%, y ELA con afectación bulbar, 18 (43,1%. Se alimentaron a través de GEP 34 pacientes (87,2%, con gastrostomía quirúrgica 3 (7,7% y mediante sonda nasogástrica 3 (7,7%. La gastrostomía percutánea endoscópica se realizó tras la inclusión de los pacientes en el programa, con una media días de 222,7 + 356,6 (IC 95% 110,8-334,7. En pacientes con ELA la media fue de 271,4 + 449,5 días (IC 95% 130,3-412,1, con ELA y afectación bulbar de 126,4 + 131,3 días (IC 95% 90-172,6. El recambio de sonda fue de 7,3 + 4,8 meses (IC 95% 4-10,6. La nutrición enteral tuvo una duración media de 578,6 + 872,9 días (IC 95% 304,7-852,6. Se hallaron complicaciones en 35 pacientes (89,7%, y solamente en 4, no se encontró ninguna (10,3%. Ver tabla II. El estreñimiento se manifestó, después del inicio de la NE, en 30 pacientes (76,9%; sin embargo, ya existía previamente en 18 de

  18. Control design approaches for nonlinear systems using multiple models

    Institute of Scientific and Technical Information of China (English)

    Junyong ZHAI; Shumin FEI; Feipeng DA

    2007-01-01

    It is difficult to realize control for some complex nonlinear systems operated in different operating regions.Based on developing local models for different operating regions of the process, a novel algorithm using multiple models is proposed. It utilizes dynamic model bank to establish multiple local models, and their membership functions are defined according to respective regions. Then the nonlinear system is approximated to a weighted combination of the local models.The stability of the nonlinear system is proven. Finally, simulations are given to demonstrate the validity of the proposed method.

  19. Valor del grosor de la capa de fibras nerviosas de la retina medido mediante tomografía de coherencia óptica como marcador de daño neuroaxonal en la esclerosis múltiple

    OpenAIRE

    López Lizcano, Ruth María

    2012-01-01

    Estudio del valor del grosor de la Capa de Fibras Nerviosas de la Retina (CFNR) a lo largo de un año como marcador de daño neuroaxonal en pacientes con distintos estadios de Esclerosis Múltiple (EM): pacientes con síndrome clínico aislado (CIS) que es el estadio más inicial de enfermedad desmielinizante, pacientes con esclerosis múltiple remitente-recurrente (EMRR) y pacientes con esclerosis múltiple primaria-progresiva (EMPP) frente a sujetos sanos. Estudio de las posibles correlaciones exis...

  20. Uso de esteronitronas para el tratamiento y prevención del ictus o accidente cerebrovascular, enfermedades de alzheimer, parkinson y esclerosis lateral amiotrófica

    OpenAIRE

    Marco-Contelles, José; Alcázar González, Alberto

    2013-01-01

    Uso y preparación de esteronitronas con alta permeabilidad a la barrera hematoencefálica, capacidad antioxidante y neuroprotectora, como potenciales fármacos para el tratamiento del ictus o accidente cerebrovascular, enfermedades de Alzheimer, Parkinson y esclerosis lateral amiotrófica.

  1. Perfil clínico y hallazgos diagnósticos en pacientes con esclerosis múltiple en Bogotá, Colombia

    OpenAIRE

    Roa Henríquez, Eglett Sofía

    2010-01-01

    Estudio descriptivo en el que se evaluaron 40 pacientes con diagnostico de esclerosis múltiple en la ciudad de Bogotá y se realizo un análisis de sus aspectos demográficos, características clínicas, curso de la enfermedad, estudios diagnósticos y aspectos del tratamiento.

  2. New approach to multiple attribute decision making with interval numbers

    Institute of Scientific and Technical Information of China (English)

    Zhang Quan; Gao Qisheng; Geng Jinhua

    2008-01-01

    In an ambiguous decision domain, the evaluation values of alternatives against attributes would be interval numbers because of the inherent, uncertain property of the problems. By using a number of linear program-ming models, Bryson and Mobolurin propose an approach to compute attribute weights and overall values of the alternatives in the form of interval numbers. The intervals of the overall values of alternatives are then transformed into points or crisp values for comparisons among the alternatives. However, the attribute weights are different because of the use of linear programming models in Bryson and Mobolurin's approach. Thus, the alternatives are not comparable because different attribute weights are employed to calculate the overall values of the alternatives.A new approach is proposed to overcome the drawbacks of Bryson and Mobolurin's approach. By transforming the decision matrix with intervals into the one with crisp values, a new linear programming model is proposed, to calculate the attribute weights for conducting alternative ranking.

  3. A New Variational Approach for Multiplicative Noise and Blur Removal

    Science.gov (United States)

    Ullah, Asmat; Chen, Wen; Khan, Mushtaq Ahmad; Sun, HongGuang

    2017-01-01

    This paper proposes a new variational model for joint multiplicative denoising and deblurring. It combines a total generalized variation filter (which has been proved to be able to reduce the blocky-effects by being aware of high-order smoothness) and shearlet transform (that effectively preserves anisotropic image features such as sharp edges, curves and so on). The new model takes the advantage of both regularizers since it is able to minimize the staircase effects while preserving sharp edges, textures and other fine image details. The existence and uniqueness of a solution to the proposed variational model is also discussed. The resulting energy functional is then solved by using alternating direction method of multipliers. Numerical experiments showing that the proposed model achieves satisfactory restoration results, both visually and quantitatively in handling the blur (motion, Gaussian, disk, and Moffat) and multiplicative noise (Gaussian, Gamma, or Rayleigh) reduction. A comparison with other recent methods in this field is provided as well. The proposed model can also be applied for restoring both single and multi-channel images contaminated with multiplicative noise, and permit cross-channel blurs when the underlying image has more than one channel. Numerical tests on color images are conducted to demonstrate the effectiveness of the proposed model. PMID:28141802

  4. A New Variational Approach for Multiplicative Noise and Blur Removal.

    Science.gov (United States)

    Ullah, Asmat; Chen, Wen; Khan, Mushtaq Ahmad; Sun, HongGuang

    2017-01-01

    This paper proposes a new variational model for joint multiplicative denoising and deblurring. It combines a total generalized variation filter (which has been proved to be able to reduce the blocky-effects by being aware of high-order smoothness) and shearlet transform (that effectively preserves anisotropic image features such as sharp edges, curves and so on). The new model takes the advantage of both regularizers since it is able to minimize the staircase effects while preserving sharp edges, textures and other fine image details. The existence and uniqueness of a solution to the proposed variational model is also discussed. The resulting energy functional is then solved by using alternating direction method of multipliers. Numerical experiments showing that the proposed model achieves satisfactory restoration results, both visually and quantitatively in handling the blur (motion, Gaussian, disk, and Moffat) and multiplicative noise (Gaussian, Gamma, or Rayleigh) reduction. A comparison with other recent methods in this field is provided as well. The proposed model can also be applied for restoring both single and multi-channel images contaminated with multiplicative noise, and permit cross-channel blurs when the underlying image has more than one channel. Numerical tests on color images are conducted to demonstrate the effectiveness of the proposed model.

  5. Missing Data and Multiple Imputation: An Unbiased Approach

    Science.gov (United States)

    Foy, M.; VanBaalen, M.; Wear, M.; Mendez, C.; Mason, S.; Meyers, V.; Alexander, D.; Law, J.

    2014-01-01

    The default method of dealing with missing data in statistical analyses is to only use the complete observations (complete case analysis), which can lead to unexpected bias when data do not meet the assumption of missing completely at random (MCAR). For the assumption of MCAR to be met, missingness cannot be related to either the observed or unobserved variables. A less stringent assumption, missing at random (MAR), requires that missingness not be associated with the value of the missing variable itself, but can be associated with the other observed variables. When data are truly MAR as opposed to MCAR, the default complete case analysis method can lead to biased results. There are statistical options available to adjust for data that are MAR, including multiple imputation (MI) which is consistent and efficient at estimating effects. Multiple imputation uses informing variables to determine statistical distributions for each piece of missing data. Then multiple datasets are created by randomly drawing on the distributions for each piece of missing data. Since MI is efficient, only a limited number, usually less than 20, of imputed datasets are required to get stable estimates. Each imputed dataset is analyzed using standard statistical techniques, and then results are combined to get overall estimates of effect. A simulation study will be demonstrated to show the results of using the default complete case analysis, and MI in a linear regression of MCAR and MAR simulated data. Further, MI was successfully applied to the association study of CO2 levels and headaches when initial analysis showed there may be an underlying association between missing CO2 levels and reported headaches. Through MI, we were able to show that there is a strong association between average CO2 levels and the risk of headaches. Each unit increase in CO2 (mmHg) resulted in a doubling in the odds of reported headaches.

  6. Capitalising on multiplicity: an transdisciplinary systems approach to landscape research

    NARCIS (Netherlands)

    Tress, B.; Tress, G.

    2001-01-01

    Different disciplines have landscape as the focal point of their research. They are successful in presenting new findings about landscapes within their specialization, but collaboration - and thus, transfer of knowledge across disciplinary boundaries - is seldom realized because a common approach th

  7. Integrating Stratification and Information Approaches for Multiple Constrained CAT.

    Science.gov (United States)

    Leung, Chi-Keung; Chang, Hua-Hua; Hau, Kit-Tai

    It is widely believed that item selection methods using the maximum information approach (MI) can maintain high efficiency in trait estimation by repeatedly choosing high discriminating (alpha) items. However, the consequence is that they lead to extremely skewed item exposure distribution in which items with high alpha values becoming overly…

  8. New approaches in the management of multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Laurie J Barten

    2010-11-01

    Full Text Available Laurie J Barten1, Douglas R Allington1, Kendra A Procacci2, Michael P Rivey11The University of Montana and Community Medical Center, Missoula, MT, USA; 2The University of Montana School of Pharmacy, Missoula, MT, USAAbstract: Multiple sclerosis (MS is a central nervous system chronic inflammatory disease that is characterized by an extensive and complex immune response. Scientific advances have occurred in immunology, pathophysiology, and diagnostic and clinical assessment tools, and recent discovery of unique therapeutic targets has spurred numerous Phase II and Phase III clinical trials. Reductions in MS relapse rates and improvements in T2 or gadolinium-enhancing lesion burdens have been reported from Phase III trials that include fingolimod, alemtuzumab, cladribine, and rituximab. Promising Phase II trial data exist for teriflunomide, daclizumab, laquinimod, and fumarate. The optimism created by these favorable findings must be tempered with evaluation of the adverse effect profile produced by these new agents. Given the discovery of progressive multifocal leukoencephalopathy with the use of natalizumab, ongoing vigilance for rare and life-threatening reactions due to new agents should be paramount. Patients with MS often experience difficulty with ambulation, spasticity, and cognition. Recent clinical trial data from two Phase III dalfampridine-SR trials indicate certain patients receive benefits in ambulation. This article provides an overview of data from clinical trials of newer agents of potential benefit in MS.Keywords: multiple sclerosis, Phase II trials, Phase III trials, progressive multifocal leukoencephalopathy, monoclonal antibody

  9. AN APPROACH FOR COMMON INTERFACE FOR MULTIPLE ONLINE BANKING (CIMOBM

    Directory of Open Access Journals (Sweden)

    Sree Rekha Gurajala

    2012-04-01

    Full Text Available This research work was initiated with a main objective of providing progressively higher degree of security in online banking (web bank ing for future generation Internet banking. The underlying knowledge models are represented using petrinet formalism in all the phases and systems. The plan is also represented using petrinets. Hierarchical timed petrinets (HTPN is used for our modeling, since it captures the temporal requirements of the real time online banking operations as well as facilitates the modeling of the large-scale system with multiple levels of abstraction. The necessary primitives for the plan representation includi ng concurrency, synchronization, temporal, activity sequencing, mutual exclusion, resource constraints and decision making actions are defined using petrinet constructs. The static and dynamic actions as well as resource modeling are illustrated using timed petri net model, developed using HPsim tool. Planning a petrinet framework is one of the easy understandable ways of representing complex problems and various issues involved. We have presented some simulation models for representing the complex web-banking model which is common for multiple banks.

  10. Diagnosis of Multiple Fixture Faults in Multiple-Station Manufacturing Processes Based on State Space Approach

    Institute of Scientific and Technical Information of China (English)

    田兆青; 来新民; 林忠钦

    2004-01-01

    Dimensional quality is one of the most critical challenges in industries, which uses the multistage manufacturing process (MMP) such as assembly and machining for automotive and aerospace industries. According to investigations, fixture faults accounted for 72% of all the dimensional faults. Previous studies focused on only one fault or multiple faults occurred in one station or one fault in multiple stations, but these cases rarely appear in the real manufacturing. This paper presents a method for diagnosis of multiple fixture faults in the multi-station manufacturing process. The proposed method is based on the state space model of the MMP processes, which carries the information of the fixture layout geometry and sensor position. To identify the root cause, three continuous steps were used: a) development of the state space model and the construction of the statistics variables on offline mode, b) measurement of the coordinate measuring machines data on online mode and calculation of the statistics variables, and c) diagnostic algorithm for identifying the root cause. The presented paper integrates the state space model of the manufacturing processes and hypothesis test considering the impact of the measure noises. A case study verifies the proposed method.

  11. An algorithmic approach to multiple complete digest mapping

    Energy Technology Data Exchange (ETDEWEB)

    Fasulo, D.P.; Karp, R.M.; Thayer, E.C. [Univ. of Washington, Seattle, WA (United States)] [and others

    1997-12-01

    Multiple Complete Digest (MCD) mapping is a method of determining the locations of restriction sites along a target DNA strand. The resulting restriction sites along a target DNA strand. The resulting restriction map has many potential applications in DNA sequencing and genetics. In this work, we present a heuristic for fragment identification, one step in the process of constructing an MCD map. We assume that we are given information about one or more complete digestions of a clone library covering the area to be mapped. From this data, we identify groups of restriction fragments on different clones that correspond to the same region of the target DNA. Maintaining certain constraints on the groups allows us to form a system of simple linear inequalities whose solution yields the desired map. We demonstrate the effectiveness of our heuristic on real data provided by the Genome Center at the University of Washington. 5 refs., 6 figs.

  12. Vital Approach to Transition: Slovene Multiple Case Study

    Directory of Open Access Journals (Sweden)

    Suzanne Winbauer Catana

    2003-03-01

    Full Text Available This paper uses a multiple case study to suggest the effectiveness in application of an integrated model for the design of sustainable change strategies in high velocity environments and organizations. The model integrates awareness of current organizational cultural characteristics with leadership intent and strategy formation. The cultural analysis provides a lens through which diverse organizational values are exposed and stakeholders can assess organizational alignment with the external environment, organizational mission and future vision. Using the inherent differentiation of values as creative tensions, strategies are formulated for purposeful change to improve alignment. Leadership inquiry is used to suggest an alignment of personal intent with the strategic initiatives to project sustainable change. This Values, Inquiry, and Tensions Alignment for Leadership model (VITAL is applied as an intervention sequence which provides information, direction, and motivation for sustainable change in transition organizations and environments.

  13. Multiple Targeting Approaches on Histamine H3 Receptor Antagonists.

    Science.gov (United States)

    Khanfar, Mohammad A; Affini, Anna; Lutsenko, Kiril; Nikolic, Katarina; Butini, Stefania; Stark, Holger

    2016-01-01

    With the very recent market approval of pitolisant (Wakix®), the interest in clinical applications of novel multifunctional histamine H3 receptor antagonists has clearly increased. Since histamine H3 receptor antagonists in clinical development have been tested for a variety of different indications, the combination of pharmacological properties in one molecule for improved pharmacological effects and reduced unwanted side-effects is rationally based on the increasing knowledge on the complex neurotransmitter regulations. The polypharmacological approaches on histamine H3 receptor antagonists on different G-protein coupled receptors, transporters, enzymes as well as on NO-signaling mechanism are described, supported with some lead structures.

  14. Multiple Targeting Approaches on Histamine H3 Receptor Antagonists

    Directory of Open Access Journals (Sweden)

    Mohammad eKhanfar

    2016-05-01

    Full Text Available With the very recent market approval of pitolisant (Wakix®, the interest in clinical applications of novel multifunctional histamine H3 receptor antagonists has clearly increased. Since histamine H3 receptor antagonists in clinical development have been tested for a variety of different indications, the combination of pharmacological properties in one molecule for improved pharmacological effects and reduced unwanted side-effects is rationally based on the increasing knowledge on the complex neurotransmitter regulations. The polypharmacological approaches on histamine H3 receptor antagonists on different G-protein coupled receptors, transporters, enzymes as well as on NO-signaling mechanism are described, supported with some lead structures.

  15. A Systematic Approach to Multiple Breath Nitrogen Washout Test Quality

    Science.gov (United States)

    Klingel, Michelle; Pizarro, Maria Ester; Hall, Graham L.; Ramsey, Kathryn; Foong, Rachel; Saunders, Clare; Robinson, Paul D.; Webster, Hailey; Hardaker, Kate; Kane, Mica; Ratjen, Felix

    2016-01-01

    Background Accurate estimates of multiple breath washout (MBW) outcomes require correct operation of the device, appropriate distraction of the subject to ensure they breathe in a manner representative of their relaxed tidal breathing pattern, and appropriate interpretation of the acquired data. Based on available recommendations for an acceptable MBW test, we aimed to develop a protocol to systematically evaluate MBW measurements based on these criteria. Methods 50 MBW test occasions were systematically reviewed for technical elements and whether the breathing pattern was representative of relaxed tidal breathing by an experienced MBW operator. The impact of qualitative and quantitative criteria on inter-observer agreement was assessed across eight MBW operators (n = 20 test occasions, compared using a Kappa statistic). Results Using qualitative criteria, 46/168 trials were rejected: 16.6% were technically unacceptable and 10.7% were excluded due to inappropriate breathing pattern. Reviewer agreement was good using qualitative criteria and further improved with quantitative criteria from (κ = 0.53–0.83%) to (κ 0.73–0.97%), but at the cost of exclusion of further test occasions in this retrospective data analysis. Conclusions The application of the systematic review improved inter-observer agreement but did not affect reported MBW outcomes. PMID:27304432

  16. A Systematic Approach to Multiple Breath Nitrogen Washout Test Quality.

    Directory of Open Access Journals (Sweden)

    Renee Jensen

    Full Text Available Accurate estimates of multiple breath washout (MBW outcomes require correct operation of the device, appropriate distraction of the subject to ensure they breathe in a manner representative of their relaxed tidal breathing pattern, and appropriate interpretation of the acquired data. Based on available recommendations for an acceptable MBW test, we aimed to develop a protocol to systematically evaluate MBW measurements based on these criteria.50 MBW test occasions were systematically reviewed for technical elements and whether the breathing pattern was representative of relaxed tidal breathing by an experienced MBW operator. The impact of qualitative and quantitative criteria on inter-observer agreement was assessed across eight MBW operators (n = 20 test occasions, compared using a Kappa statistic.Using qualitative criteria, 46/168 trials were rejected: 16.6% were technically unacceptable and 10.7% were excluded due to inappropriate breathing pattern. Reviewer agreement was good using qualitative criteria and further improved with quantitative criteria from (κ = 0.53-0.83% to (κ 0.73-0.97%, but at the cost of exclusion of further test occasions in this retrospective data analysis.The application of the systematic review improved inter-observer agreement but did not affect reported MBW outcomes.

  17. A Multiple Model Approach to Modeling Based on Fuzzy Support Vector Machines

    Institute of Scientific and Technical Information of China (English)

    冯瑞; 张艳珠; 宋春林; 邵惠鹤

    2003-01-01

    A new multiple models(MM) approach was proposed to model complex industrial process by using Fuzzy Support Vector Machines (F SVMs). By applying the proposed approach to a pH neutralization titration experi-ment, F_SVMs MM not only provides satisfactory approximation and generalization property, but also achieves superior performance to USOCPN multiple modeling method and single modeling method based on standard SVMs.

  18. An agent-based negotiation approach for balancing multiple coupled control domains

    DEFF Research Database (Denmark)

    Umair, Aisha; Clausen, Anders; Jørgensen, Bo Nørregaard

    2015-01-01

    Solving multi-objective multi-issue negotiation problems involving interdependent issues distributed among multiple control domains is inherent to most non-trivial cyber-physical systems. In these systems, the coordinated operation of interconnected subsystems performing autonomous control....... The proposed approach can solve negotiation problems with interdependent issues across multiple coupled control domains. We demonstrate our approach by solving a coordination problem where a Combined Heat and Power Plant must allocate electricity for three commercial greenhouses to ensure the required plant...

  19. A Novel Approach to Discriminate Subgroups in Multiple Sclerosis

    Directory of Open Access Journals (Sweden)

    Mehrdad Farrokhi

    2017-01-01

    Full Text Available Multiple sclerosis (MS is an autoimmune disease of central nervous system. Since different types of immune cells are involved in MS pathogenesis, in this study we aimed to evaluate serum levels of several immunological components including soluble CD4 (sCD4, sCD8, sCD163, and immunoglobulins as markers of activity of T-cells, macrophages, and B-cells in different types of MS. Serum levels of sCD4, sCD8, and sCD163 of patients with relapsing-remitting MS (RRMS, n=61, primary progressive MS (PRMS, n=31, secondary progressive MS (SPMS, n=31, clinical isolated syndrome (CIS, n=31 and neuromyelitis optica (NMO, n=31, and healthy controls (n=49 were measured using enzyme-linked immunosorbent assay (ELISA. Serum levels of Ig-G, Ig-M, and Ig-A were determined using nephelometric technique. Serum levels of sCD4, sCD8, sCD163, Ig-G, Ig-M, and Ig-A were significantly different in five groups of cases (p<0.05. Furthermore, application of stepwise method of discriminant analysis yielded 4 significant discriminant functions of classification due to the presence of six levels of categorical variables in the analysis. The most important function explained 85.5% of the total variance with the correlation value of 0.79. Taken together, our preliminary analysis suggests that although we found some functions to discriminate most of the patients, further studies will be required to individuate immunological markers characterizing the different type of MS including RRMS, PPMS, SPMS, CIS and NMO as proved by the data on sCD4, sCD163, Ig-M, and Ig-G in blood. 

  20. La esclerosis múltiple en el embarazo: reporte de tres casos en el Hospital Universitario de San Ignacio (HUSI)

    OpenAIRE

    Toro C., Angélica María; Pontificia Universidad Javeriana

    2012-01-01

    Introducción: Se presentan tres casos de pacientes con esclerosis múltiple (EM), diagnosticadas previo al embarazo, y que fueron evaluadas en la Unidad de Medicina Materno-Fetal durante sus controles y parto en el Hospital Universitario de San Ignacio, centro de referencia nivel IV que atiende población embarazada de alto riesgo obstétrico perteneciente al régimen contributivo.Objetivo: Describir las formas de presentación, fisiopatología, etiología y cuadro clínico de la EM, así como su comp...

  1. Novel approaches to understanding carbon redistribution at multiple scales

    Science.gov (United States)

    Dungait, Jennifer; Beniston, Joshua; Lal, Rattan; Horrocks, Claire; Collins, Adrian; Mariappen, Sankar; Quine, Timothy

    2014-05-01

    Established biogeochemical techniques are used to trace organic inputs typically derived directly or indirectly from plants into soils, sediments and water using lipid biomarkers. Recently, advances in bulk and compound specific stable 13C isotope analyses have provided novel ways of exploring the source and residence times of organic matter in soils using the natural abundance stable 13C isotope signature of C3 and C4 plant end member values. However, the application of biogeochemical source tracing technologies at the molecular level at field to catchment scales has been slow to develop because of perceived problems with dilution of molecular-scale signals. This paper describes the results of recent experiments in natural and agricultural environments in the UK (Collins et al., 2013; Dungait et al., 2013) and United States (Beniston et al., submitted) that have successfully applied new tracing techniques using stable 13C isotope and complementary approaches to explore the transport of sediment-bound organic carbon at a range of scales from the small plot (m2) to field (ha) and small catchment (10's ha). References Beniston et al (submitted) The effects of crop residue removal on soil erosion and macronutrient dynamics on soils under no till for 42 years. Biogeosciences Collins et al (2013) Catchment source contributions to the sediment-bound organic matter degrading salmonid spawning gravels in a lowland river, southern England. Science of the Total Environment 456-457, 181-195. Dungait et al (2013) Microbial responses to the erosional redistribution of soil organic carbon in arable fields. Soil Biology and Biochemistry 60, 195-201. Puttock et al (2012) Stable carbon isotope analysis of fluvial sediment fluxes over two contrasting C4-C3 semi-arid vegetation transitions. Rapid Communications in Mass Spectrometry 26, 2386-2392.

  2. Scenario-based modeling for multiple allocation hub location problem under disruption risk: multiple cuts Benders decomposition approach

    Science.gov (United States)

    Yahyaei, Mohsen; Bashiri, Mahdi

    2017-03-01

    The hub location problem arises in a variety of domains such as transportation and telecommunication systems. In many real-world situations, hub facilities are subject to disruption. This paper deals with the multiple allocation hub location problem in the presence of facilities failure. To model the problem, a two-stage stochastic formulation is developed. In the proposed model, the number of scenarios grows exponentially with the number of facilities. To alleviate this issue, two approaches are applied simultaneously. The first approach is to apply sample average approximation to approximate the two stochastic problem via sampling. Then, by applying the multiple cuts Benders decomposition approach, computational performance is enhanced. Numerical studies show the effective performance of the SAA in terms of optimality gap for small problem instances with numerous scenarios. Moreover, performance of multi-cut Benders decomposition is assessed through comparison with the classic version and the computational results reveal the superiority of the multi-cut approach regarding the computational time and number of iterations.

  3. Strongly and weakly directed approaches to teaching multiple representation use in physics

    Directory of Open Access Journals (Sweden)

    David Rosengrant

    2007-06-01

    Full Text Available Good use of multiple representations is considered key to learning physics, and so there is considerable motivation both to learn how students use multiple representations when solving problems and to learn how best to teach problem solving using multiple representations. In this study of two large-lecture algebra-based physics courses at the University of Colorado (CU and Rutgers, the State University of New Jersey, we address both issues. Students in each of the two courses solved five common electrostatics problems of varying difficulty, and we examine their solutions to clarify the relationship between multiple representation use and performance on problems involving free-body diagrams. We also compare our data across the courses, since the two physics-education-research-based courses take substantially different approaches to teaching the use of multiple representations. The course at Rutgers takes a strongly directed approach, emphasizing specific heuristics and problem-solving strategies. The course at CU takes a weakly directed approach, modeling good problem solving without teaching a specific strategy. We find that, in both courses, students make extensive use of multiple representations, and that this use (when both complete and correct is associated with significantly increased performance. Some minor differences in representation use exist, and are consistent with the types of instruction given. Most significant are the strong and broad similarities in the results, suggesting that either instructional approach or a combination thereof can be useful for helping students learn to use multiple representations for problem solving and concept development.

  4. The theory of gyrokinetic turbulence: A multiple-scales approach

    Science.gov (United States)

    Plunk, Gabriel Galad

    Gyrokinetics is a rich and rewarding playground to study some of the mysteries of modern physics -- such as turbulence, universality, self-organization and dynamic criticality -- which are found in physical systems that are driven far from thermodynamic equilibrium. One such system is of particular importance, as it is central in the development of fusion energy -- this system is the turbulent plasma found in magnetically confined fusion device. In this thesis I present work, motivated by the quest for fusion energy, which seeks to uncover some of the inner workings of turbulence in magnetized plasmas. I present three projects, based on the work of me and my collaborators, which take a tour of different aspects and approaches to the gyrokinetic turbulence problem. I begin with the fundamental theory of gyrokinetics, and a novel formulation of its extension to the equations for mean-scale transport -- the equations which must be solved to determine the performance of Magnetically confined fusion devices. The results of this work include (1) the equations of evolution for the mean scale (equilibrium) density, temperature and magnetic field of the plasma, (2) a detailed Poynting's theorem for the energy balance and (3) the entropy balance equations. The second project presents gyrokinetic secondary instability theory as a mechanism to bring about saturation of the basic instabilities that drive gyrokinetic turbulence. Emphasis is put on the ability for this analytic theory to predict basic properties of the nonlinear state, which can be applied to a mixing length phenomenology of transport. The results of this work include (1) an integral equation for the calculation of the growth rate of the fully gyrokinetic secondary instability with finite Larmor radius (FLR) affects included exactly, (2) the demonstration of the robustness of the secondary instability at fine scales (krhoi for ion temperature gradient (ITG) turbulence and krhoe ≪ 1 for electron temperature

  5. Determinación de infecciones sistémicas por micoplasma en pacientes con esclerosis lateral amiotrófica clínicamente definida

    OpenAIRE

    Flores Río de la Loza,Luis Javier; Ordoñez Lozano,Graciela; Pineda Olvera,Benjamín

    2004-01-01

    La esclerosis lateral amiotrófica es una enfermedad degenerativa con curso progresivo y fatal. Se estudiaron 75 pacientes en el curso de un año en el Instituto Nacional de Neurología y Neurocirugía usando los anteriores diagnósticos como el escorial. Se tomaron muestras sanguíneas y se práctico prueba de detección del micoplasmas plus. Se encontró una relación entre la infección crónica del micoplasma y la esclerosis lateral amiotrófica, como se ha demostrado en otros estudios. Sin embargo, n...

  6. Comparative study of the multiple fault isolation approaches based on the structures of residual sets

    Science.gov (United States)

    Bartyś, Michał

    2014-12-01

    This paper presents a comparative study of the applicability features of the three chosen multiple fault isolation approaches based on the binary evaluated structures of residual sets. Firstly, all considered approaches are briefly described. Then, their computational effectiveness is discussed. Next, the low-level implementation of the compared approaches is characterised and the set of experimental results is presented. Finally, the results of experiments are discussed and the appropriate recommendations for diagnostic engineering practice are formulated.

  7. Limited Multiple-Writer: An Approach to Dealing with False Sharing in Software DSMs

    Institute of Scientific and Technical Information of China (English)

    谢向辉; 韩承德

    2000-01-01

    False sharing is one of the most important factors impacting the performance of DSM (distributed shared memory) systems. The single-writer ap proach is simple, but it cannot avoid the ping-pong effect of the data page thrashing, while the multiple-writer approach is effective for false sharing but with high cost. This paper proposes a new approach, called limited multiple-writer (LMW) to han dling multiple writers in software DSM. It distinguishes two kinds of multiple-writer as lock-based form and barrier-based form, and handles them with different policies. It discards the Twin and Diff in traditional multiple-writer approach, and simplifies the implementation of niultiple-writer in software DSM systems. The implementa tion of LMW in a CVM (Coherent Virtual Machine) software DSM system, which is based on a network of workstations, is introduced. Evaluation results show that for some applications such as SOR (Successive Over-Relaxation), LU (Lower triangular and Upper triangular), FFT (Fast Fourier Transformation), and IS (Integer Sorting), LMW provides a significant reduction inexecution time (11%, 16%, 33% and 46%) compared with the traditional multiple-writer approach on the platform.

  8. The double travelling salesman problem with multiple stacks - Formulation and heuristic solution approaches

    DEFF Research Database (Denmark)

    Petersen, Hanne Løhmann; Madsen, Oli B.G.

    2009-01-01

    This paper introduces the double travelling salesman problem with multiple stacks and presents four different metaheuristic approaches to its solution. The double TSP with multiple stacks is concerned with determining the shortest route performing pickups and deliveries in two separated networks...... different neighbourhood structures are developed for the problem and used with each of three local search metaheuristics. Additionally some simpler removal and reinsertion operators are used in a Large neighbourhood search framework. Finally some computational results are given along with lower bounds...

  9. A Monte Carlo Study on Multiple Output Stochastic Frontiers: Comparison of Two Approaches

    DEFF Research Database (Denmark)

    Henningsen, Geraldine; Henningsen, Arne; Jensen, Uwe

    In the estimation of multiple output technologies in a primal approach, the main question is how to handle the multiple outputs. Often an output distance function is used, where the classical approach is to exploit its homogeneity property by selecting one output quantity as the dependent variable...... as directional components as regressors. A number of studies have compared these specifications using real world data and have found significant differences in the inefficiency estimates. However, in order to get to the bottom of these differences, we apply a Monte-Carlo simulation. We test the robustness...

  10. [Cognitive performance and quality of life in multiple sclerosis in Gipuzkoa].

    Science.gov (United States)

    Sistiaga, Andone; Castillo-Triviño, Tamara; Aliri, Jone; Gaztañaga, Mirari; Acha, Joana; Arruti, Maialen; Otaegui, David; Olascoaga, Javier

    2014-04-16

    Introduccion. El deterioro cognitivo y la presencia de sintomas depresivos, comunes en los pacientes con esclerosis multiple, inciden en la calidad de vida de los pacientes. Objetivo. Describir la calidad de vida, la afectacion cognitiva y los niveles de depresion, en relacion con otras variables clinicas, en los pacientes con esclerosis multiple de la provincia de Gipuzkoa. Pacientes y metodos. Se evaluo neuropsicologicamente a 114 pacientes. Se incluyeron el MSQoL-54 y el inventario de depresion de Beck para evaluar la calidad de vida y los niveles de depresion. Se emprendieron tres analisis principales: comparacion del rendimiento cognitivo entre subtipos, analisis de correlacion entre variables clinicas, neuropsicologicas y de calidad de vida, y analisis sobre los efectos del genero en el rendimiento cognitivo. Resultados. Se halla en la esclerosis multiple un patron neuropsicologico caracterizado por enlentecimiento en el procesamiento de la informacion y dificultades atencionales. La calidad de vida se relaciona con sintomas depresivos y con el rendimiento cognitivo global pero no con factores clinicos como la tasa de brote o la duracion de la enfermedad. Los datos confirman un peor rendimiento cognitivo en los hombres, sobre todo en la memoria auditiva verbal. Conclusiones. El genero se presenta como un factor modulador en el impacto de la enfermedad sobre el rendimiento cognitivo, que refuerza el interes de estudios que clarifiquen el origen de dichas diferencias. Ademas, la calidad de vida muestra una mayor relacion con la adaptacion a la enfermedad que con sus sintomas.

  11. An iterative fullwave simulation approach to multiple scattering in media with randomly distributed microbubbles.

    Science.gov (United States)

    Joshi, Aditya; Lindsey, Brooks; Dayton, Paul; Pinton, Gianmarco; Muller, Marie

    2017-03-07

    - Ultrasound contrast agents (UCA), such as microbubbles, enhance the scattering properties of blood, which is otherwise hypoechoic. The multiple scattering interactions of the acoustic field with UCA's are poorly understood due to the complexity of the multiple scattering theories and the nonlinear microbubble response. The majority of bubble models describe the behavior of UCA's as single, isolated microbubbles suspended in infinite medium. Multiple scattering models such as the Independent Scattering Approximation can approximate phase velocity and attenuation for low scatterer volume fraction. However, all current models and simulations approach only describe multiple scattering and nonlinear bubble dynamics separately. Here we present an approach that combines two existing models: 1) a full-wave model that describes nonlinear propagation and scattering interactions in a heterogeneous attenuating medium and 2) a Paul-Sarkar model that describes the nonlinear interactions between an acoustic field and microbubbles. These two models were solved numerically and combined with an iterative approach. The convergence of this combined model was explored in silico for 0.5%, 1% and 2% bubble concentration by volume. The backscattering predicted by our modeling approach was verified experimentally with water tank measurements performed with a 128-element linear array transducer. An excellent agreement in terms of the fundamental and harmonic acoustic fields is shown. Additionally, our model correctly predicts the phase velocity and attenuation measured using through transmission and predicted by the Independent Scattering Approximation.

  12. Multiple Realities: A Relationship Narrative Approach in Therapy with Black-White Mixed-Race Clients.

    Science.gov (United States)

    Rockquemore, Kerry Ann; Laszloffy, Tracey A.

    2003-01-01

    Emerging empirical research on racial identity formation among persons with one Black and one White parent reveals that multiple identity options are possible. Presents a relational narrative approach to therapy with Black-White mixed-race clients who experience systematic invalidation of their chosen racial identity through a detailed case…

  13. A Multiple-Strategy-Based Approach to Word and Collocation Acquisition

    Science.gov (United States)

    Myers, James L.; Chang, Shu-Fen

    2009-01-01

    Acquiring an adequate vocabulary is a cognitive challenge for foreign language learners. Varied exposures to newly acquired words as they occur in meaningful contexts may facilitate the process of vocabulary learning. In this study we investigated the effects of such a multiple-strategy-based vocabulary teaching approach. We conducted an…

  14. Improving Students' Creative Thinking and Achievement through the Implementation of Multiple Intelligence Approach with Mind Mapping

    Science.gov (United States)

    Widiana, I. Wayan; Jampel, I. Nyoman

    2016-01-01

    This classroom action research aimed to improve the students' creative thinking and achievement in learning science. It conducted through the implementation of multiple intelligences with mind mapping approach and describing the students' responses. The subjects of this research were the fifth grade students of SD 8 Tianyar Barat, Kubu, and…

  15. Predicting Speech Intelligibility with a Multiple Speech Subsystems Approach in Children with Cerebral Palsy

    Science.gov (United States)

    Lee, Jimin; Hustad, Katherine C.; Weismer, Gary

    2014-01-01

    Purpose: Speech acoustic characteristics of children with cerebral palsy (CP) were examined with a multiple speech subsystems approach; speech intelligibility was evaluated using a prediction model in which acoustic measures were selected to represent three speech subsystems. Method: Nine acoustic variables reflecting different subsystems, and…

  16. Multiple Solutions Approach (MSA): Conceptions and Practices of Primary School Teachers in Ghana

    Science.gov (United States)

    Nabie, Michael Johnson; Raheem, Kolawole; Agbemaka, John Bijou; Sabtiwu, Rufai

    2016-01-01

    The study explored the curriculum guidelines and primary school teachers' conceptions and practices of the Multiple Solutions Approach (MSA) in teaching mathematics using basic qualitative research design. Informal conversation interviews (ICIs), observations, video and document analyses were used to collect data. Participants included a purposive…

  17. An approach to implement PSO to optimize outage probability of coded cooperative communication with multiple relays

    Directory of Open Access Journals (Sweden)

    Sindhu Hak Gupta

    2016-09-01

    Full Text Available Coded Cooperative Communication is a novel concept and it is the solution to utilize the benefits of MIMO (Multiple Input Multiple Output gains on distributed scale. In this paper the outage behavior of coded cooperative communication with multiple relays is examined. The numerical expression for outage probability is derived. Nakagami-m fading statics is considered. Outage probability is observed to be function of various free and constrained parameters. An approach is presented to implement PSO and optimize the free parameters on which outage probability of coded cooperative communication with multiple relay depends. Analytical and Matlab simulation results reveal that the proposed technique outperforms Non Optimized technique and exhibit a promising performance.

  18. Enfermedad cardíaca grave en la esclerosis sistémica Severe cardiac disease in scleroderma

    Directory of Open Access Journals (Sweden)

    Alejandro R. Grinberg

    2004-10-01

    Full Text Available Una mujer de 36 años de edad con diagnóstico de esclerosis sistémica (ES desarrolló un cuadro agudo de miositis esquelética e insuficiencia cardíaca grave. Evolucionó con shock cardiogénico y a pesar del tratamiento con drogas inotrópicas y altas dosis de corticoides falleció a los cinco días de haber ingresado. La autopsia reveló áreas de necrosis coagulativa miocárdicas con miocitolisis y necrosis en banda de contracción. Son muy pocos los casos comunicados de insuficiencia cardíaca grave asociada a la ES.A 36 year-old female with a diagnosis of systemic sclerosis suffered from an acute episode of skeletal myositis and refractory heart failure with cardiogenic shock. Despite immunosuppressive treatment with high doses of corticosteroids and hemodynamic support she died five days after admission. The autopsy showed cardiac myocytolysis, myocyte necrosis and contraction band necrosis. There are very few reported cases of severe heart failure associated to systemic sclerosis.

  19. Esclerosis múltiple: análisis de necesidades y calidad de vida de los afectados y su entorno

    Directory of Open Access Journals (Sweden)

    José Carrón Sánchez

    2013-12-01

    Full Text Available La evolución en el paradigma desde el que se contempla la discapacidad, y en concreto la esclerosis múltiple, ha estado marcada por los cambios en el concepto de salud, en el avance en los derechos sociales subjetivos y en la implantación progresiva de un modelo inclusivo para su abordaje. Con esta investigación se pretende responder a las preguntas de ese nuevo paradigma, revisando la situación epidemiológica, los estudios anteriores, y el desarrollo de una metodología complementaria desde lo cuantitativo y lo cualitativo. El trabajo de campo –desarrollado en el ámbito de la Comunidad Foral de Navarra– y su posterior análisis nos ofrece una prevalencia considerablemente mayor que la habitualmente manejada hasta ahora, un perfil con características bastante estables en el que destaca el importante grado incapacitante y su correlato socioeconómico, y el aumento en los tratamientos farmacológicos respecto a datos anteriores. La ausencia de una respuesta curativa y el avance en las terapias paliativas exigen, como paso ineludible, la necesidad de poner el foco en aquellos aspectos que mejoren la calidad de vida de las personas afectadas y su entorno.

  20. A novel approach to multiple sequence alignment using hadoop data grids.

    Science.gov (United States)

    Sudha Sadasivam, G; Baktavatchalam, G

    2010-01-01

    Multiple alignment of protein sequences helps to determine evolutionary linkage and to predict molecular structures. The factors to be considered while aligning multiple sequences are speed and accuracy of alignment. Although dynamic programming algorithms produce accurate alignments, they are computation intensive. In this paper we propose a time efficient approach to sequence alignment that also produces quality alignment. The dynamic nature of the algorithm coupled with data and computational parallelism of hadoop data grids improves the accuracy and speed of sequence alignment. The principle of block splitting in hadoop coupled with its scalability facilitates alignment of very large sequences.

  1. Valor diagnóstico y pronóstico de la evaluación de la capa de fibras nerviosas de la retina en la esclerosis múltiple

    OpenAIRE

    Herrero Latorre, Raquel; Polo Llorens, Vicente; Frezzotti, Pablo; García Martín, Elena

    2013-01-01

    Introducción: El tema principal de las cuatro publicaciones internacionales que componen esta tesis doctoral se centra en el estudio de la capa de fibras nerviosas de la retina en pacientes con esclerosis múltiple como método para mejorar y acelerar el proceso diagnóstico así como el seguimiento y la monitorización de esta enfermedad. Material y Métodos: Se realizó un estudio observacional y prospectivo donde se incluyeron 150 sujetos con esclerosis múltiple y 150 sujetos sanos. El protoc...

  2. On the Interaction Between Multiple Paths and Wireless Mesh Networks Scheduler Approaches

    Directory of Open Access Journals (Sweden)

    Valeria Loscrì

    2008-07-01

    Full Text Available Multi-path routing allows building and use of multiple paths for routing between a source-destination pair. This paper investigates the problem of selecting multiple routing paths to provide better reliability and load balancing in wireless mesh networks with stationary nodes. Previous work has investigated the use of additional data redundancy to improve the throughput of the network. In these specific cases, node disjoint-ness property of the multiple paths is required. In this work we investigate multipath routing without packet duplication, and no disjointed paths for achieving better performance in terms of packet delivery rate and low delay. We propose a very simple reactive on-demand distance vector routing protocol. Multiple paths built through this approach are loop-free. In order to better exploit resources redundancy (with the term resources redundancy we mean the possibility to exploit more nodes to send data packets, it is our belief that a routing protocol cannot be independent of the MAC layer. For this reason, we evaluated our routing protocol on four different MAC approaches specifically designed for Wireless Mesh Networks (WMNs. Firstly, we implemented the Coordinated Distributed Scheduler scheme of the Std. IEEE 802.16. Secondly, since some parameters have been left unstandardized in this scheme, we proposed an enhanced version of the CDS, in which a simple and dynamic criterion has been designed to set one of these parameters. Furthermore, we proposed two different scheduling schemes called Randomized- MAC (R-MAC and Distributed Scheduling Scheme (DSS. We evaluated the impact of multiple paths in respect of the single path on all the scheduler schemes cited above. Results show as the simple routing approach is effective with every MAC protocol considered.

  3. The multiple viewpoints as approach to information retrieval within collaborative development context

    CERN Document Server

    Geryville, Hichem; Bouras, Abdelaziz; Sapidis, Nikolaos

    2007-01-01

    Nowadays, to achieve competitive advantage, the industrial companies are considering that success is sustained to great product development. That is to manage the product throughout its entire lifecycle. Achieving this goal requires a tight collaboration between actors from a wide variety of domains, using different software tools producing various product data types and formats. The actors' collaboration is mainly based on the exchange /share product information. The representation of the actors' viewpoints is the underlying requirement of the collaborative product development. The multiple viewpoints approach was designed to provide an organizational framework following the actors' perspectives in the collaboration, and their relationships. The approach acknowledges the inevitability of multiple integration of product information as different views, promotes gathering of actors' interest, and encourages retrieved adequate information while providing support for integration through PLM and/or SCM collaborati...

  4. Comprehensive analysis of lipid composition in crude palm oil using multiple lipidomic approaches.

    Science.gov (United States)

    Cheong, Wei Fun; Wenk, Markus R; Shui, Guanghou

    2014-05-20

    Palm oil is currently the leading edible oil consumed worldwide. Triacylglycerol (TAG) and diacylglycerol (DAG) are the dominant lipid classes in palm oil. Other lipid classes present in crude palm oil, such as phospholipids and galactolipids, are very low in abundance. These low-abundance lipids constitute key intermediates in lipid biosynthesis. In this study, we applied multiple lipidomic approaches, including high-sensitivity and high-specificity multiple reaction monitoring, to comprehensively quantify individual lipid species in crude palm oil. We also established a new liquid chromatography-coupled mass spectrometry method that allows direct quantification of low-abundance galactolipids in palm oil without the need for sample pretreatment. As crude palm oil contains large amounts of neutral lipids, our direct-detection method circumvents many of the challenges encountered with conventional lipid quantification methods. This approach allows direct measurement of lipids with no hassle during sample preparation and is more accurate and precise compared with other methods.

  5. A Memory/Immunology-Based Control Approach with Applications to Multiple Spacecraft Formation Flying

    Directory of Open Access Journals (Sweden)

    Liguo Weng

    2013-01-01

    Full Text Available This paper addresses the problem of formation control for multiple spacecrafts in Planetary Orbital Environment (POE. Due to the presence of diverse interferences and uncertainties in the outer space, such as the changing spacecraft mass, unavailable space parameters, and varying gravity forces, traditional control methods encounter great difficulties in this area. A new control approach inspired by human memory and immune system is proposed, and this approach is shown to be capable of learning from past control experience and current behavior to improve its performance. It demands much less system dynamic information as compared with traditional controls. Both theoretic analysis and computer simulation verify its effectiveness.

  6. [Structural and functional changes of the hippocampus in patients with multiple sclerosis and their relationship with memory processes].

    Science.gov (United States)

    Cruz-Gómez, Álvaro J; Belenguer-Benavides, Antonio; Martínez-Bronchal, Beatriz; Fittipaldi-Márquez, M Sol; Forn, Cristina

    2016-01-01

    Introduccion. Una de las alteraciones cognitivas mas prevalentes en los pacientes con esclerosis multiple son los problemas de codificacion de la informacion (tanto verbal como visual), proceso relacionado con el hipocampo. Objetivo. Estudiar la relacion entre los procesos de aprendizaje y retencion de la informacion a largo plazo con el volumen hipocampal y la conectividad funcional (CF) en pacientes con esclerosis multiple comparados con un grupo control. Sujetos y metodos. Ambos grupos fueron evaluados con la bateria neuropsicologica breve, que incluye pruebas de memoria verbal y visual. Se realizo el estudio de volumetria de la sustancia gris mediante la tecnica de morfometria basada en el voxel y un estudio de CF de voxel de semilla centrado en la zona de interes (hipocampo). Se realizaron analisis de asociacion entre rendimiento en memoria y cambios volumetricos y de CF. Resultados. Los resultados mostraron atrofia en la sustancia gris en el hipocampo izquierdo y una menor CF entre el hipocampo izquierdo y el troncoencefalo, el cerebelo, el giro fusiforme y el giro temporal superior en los pacientes respecto al grupo control. En el grupo de pacientes se observa una correlacion positiva entre la sustancia gris en ambos hipocampos y el rendimiento en memoria verbal, asi como una correlacion positiva entre el rendimiento en memoria visual y la CF entre el hipocampo izquierdo y diversas regiones temporales. Conclusiones. Los resultados muestran una relacion entre el rendimiento de memoria verbal y visual, y cambios estructurales y funcionales en el hipocampo en pacientes con esclerosis multiple.

  7. A multiple endpoint approach to predict the hepatotoxicity of pharmaceuticals in vitro

    OpenAIRE

    Truisi, Germaine Loredana

    2014-01-01

    A new approach was evaluated to predict the hepatotoxic potential of pharmaceuticals. For this purpose, primary rat and human hepatocytes cultured in an optimised sandwich configuration were used; thus, allowing the long-term, repeat-dosing of drugs. The strategy based on the evaluation of multiple endpoints, including cytotoxicity, biokinetic profiling, transcriptomics and proteomics. Pharmaceuticals with known toxicities and pharmacokinetic properties were used as model compounds.

  8. The Application of a Multiple Measurement Approach to Investigate the Effects of a Dance Program on Educable Mentally Retarded Adolescents.

    Science.gov (United States)

    Crain, Cindy; And Others

    1984-01-01

    A multiple measurement approach with eight measurements was used to answer research questions regarding physical and social effects that occur when educable mentally retarded adolescents were exposed to a 10-week dance program. This approach was found to be useful for identifying multiple effects and generating hypotheses for further study.…

  9. Eficacia de las terapias celular y génica como agentes inmunomoduladores en el tratamiento de la esclerosis múltiple

    OpenAIRE

    2015-01-01

    El interferón beta (IFNb) ha sido uno de los fármacos más utilizados en el tratamiento de la esclerosis múltiple (EM), gracias a su efecto inmunomodulador, antiproliferativo y antiviral. Sin embargo, existe un porcentaje de pacientes que responden de forma subóptima al tratamiento, sugiriendo la necesidad de buscar alternativas terapéuticas innovadoras. En este contexto se ha observado que las células madre mesenquimales derivadas del tejido adiposo (AdMSCs) presentan capacidad inmunomodulado...

  10. Astrocitoma subependimario de células gigantes asociado a complejo de esclerosis tuberosa: recomendaciones para el diagnóstico oportuno y tratamiento.

    OpenAIRE

    Matilde Ruiz; Sandra Sánchez; Alejandro Rea; Roberto Sanromán; Joao García; Antonio Bravo; Infante Cantú; Hugo Ceja; Ariadna González; María del Mar Sáez

    2015-01-01

    RESUMEN El complejo de esclerosis tuberosa es una enfermedad genética poco frecuente, autosómica dominante con fenotipo y expresión clínica muy variables. Se caracteriza por alteraciones en la migración, diferenciación y proliferación celulares con formación de múltiples tumores benignos llamados hamartomas, las cuales afectan principalmente piel, encéfalo, riñón, ojo, corazón y pulmón. Los astrocitomas subependimarios de células gigantes son tumores benignos de crecimien...

  11. Rehabilitación del sistema vestibular como tratamiento para mejorar el equilibrio en pacientes con esclerosis múltiple. Revisión bibliográfica.

    OpenAIRE

    Gomez Jareño, Iera

    2016-01-01

    Antecedentes: La esclerosis múltiple es la enfermedad inflamatoria más frecuente del sistema nervioso central, y la segunda causa de discapacidad neurológica en adultos jóvenes. En este tipo de pacientes, el vértigo y la falta de equilibrio debida a alteraciones del sistema vestibular son síntomas muy comunes. Se han empleado distintos programas de entrenamiento del equilibrio entre los cuales se encuentra la rehabilitación vestibular. Objetivos: El objetivo de esta revisión es...

  12. Tratamiento fisioterápico en la esclerosis lateral amiotrófica (ELA). Revisión bibliográfica

    OpenAIRE

    Martín Bravo, Beatriz

    2014-01-01

    Dentro de las enfermedades neurodegenerativas progresivas se encuentra la esclerosis lateral amiotrófica (ELA), considerada una enfermedad devastadora debido a su carácter progresivo e invalidante, que lleva al paciente a una completa dependencia en cuestión de años e, inevitablemente, a la muerte. Supone un problema importante de salud por el tremendo sufrimiento que causa a pacientes y familiares. Sin embargo, con una correcta coordinación multidisciplinar aumentar la supervivencia en ci...

  13. Papel de los polimorfismos de los genes hemo-oxigenasa 1 y 2 en el riesgo de desarrollo de esclerosis múltiple

    OpenAIRE

    Millán Pascual, Jorge

    2016-01-01

    La esclerosis múltiple (en adelante EM) muestra una susceptibilidad genética conocida desde las primeras descripciones de la enfermedad y, aunque los esfuerzos para desentrañar y comprender las bases genéticas de la enfermedad han sido contínuos, tanto con abordajes poblacionales como moleculares, los resultados son hasta la fecha modestos. La susceptibilidad genética se confirma en hechos incuestionables como la existencia de un riesgo étnico diferente, la agregación familiar y la asimetría ...

  14. Ecografía orbitaria con medición de nervio óptico aplicada a la esclerosis múltiple

    OpenAIRE

    Pérez Sánchez, Soledad

    2016-01-01

    Falta palabras clave La esclerosis múltiple es una enfermedad inflamatoria desmielinizante que afecta al sistema nervioso central. Se ha convertido en una de las principales causas de discapacidad en adultos jóvenes, pues la edad habitual de aparición es entre los 20 y los 40 años. Las lesiones del SNC detectadas en la enfermedad se caracterizan por la disrupción de la barrera hematoencefálica, inflamación, desmielinización, pérdida de oligodendrocitos, gliosis reactiva y degeneración neur...

  15. La fatiga y los trastornos cognitivos asociados a la esclerosis múltiple. Aspectos a considerar en el abordaje de Fisioterapia.

    OpenAIRE

    Concejero Gómez de Salazar, Belén

    2013-01-01

    Este trabajo establece una visión general de la esclerosis múltiple tratando los siguientes puntos: Concepto, historia, diagnóstico, anatomía, epidemiología, etiología, pronóstico y alteraciones asociadas. Se centra en los trastornos motores, en los cognitivos y en la fatiga para estudiar las posibles repercusiones en el tratamiento de Fisioterapia. Bajo la perspectiva de un equipo interdisciplinar se desarrollan unas pautas que puedan ayudar al fisioterapeuta en el manejo del paciente con E...

  16. An optimization based sampling approach for multiple metrics uncertainty analysis using generalized likelihood uncertainty estimation

    Science.gov (United States)

    Zhou, Rurui; Li, Yu; Lu, Di; Liu, Haixing; Zhou, Huicheng

    2016-09-01

    This paper investigates the use of an epsilon-dominance non-dominated sorted genetic algorithm II (ɛ-NSGAII) as a sampling approach with an aim to improving sampling efficiency for multiple metrics uncertainty analysis using Generalized Likelihood Uncertainty Estimation (GLUE). The effectiveness of ɛ-NSGAII based sampling is demonstrated compared with Latin hypercube sampling (LHS) through analyzing sampling efficiency, multiple metrics performance, parameter uncertainty and flood forecasting uncertainty with a case study of flood forecasting uncertainty evaluation based on Xinanjiang model (XAJ) for Qing River reservoir, China. Results obtained demonstrate the following advantages of the ɛ-NSGAII based sampling approach in comparison to LHS: (1) The former performs more effective and efficient than LHS, for example the simulation time required to generate 1000 behavioral parameter sets is shorter by 9 times; (2) The Pareto tradeoffs between metrics are demonstrated clearly with the solutions from ɛ-NSGAII based sampling, also their Pareto optimal values are better than those of LHS, which means better forecasting accuracy of ɛ-NSGAII parameter sets; (3) The parameter posterior distributions from ɛ-NSGAII based sampling are concentrated in the appropriate ranges rather than uniform, which accords with their physical significance, also parameter uncertainties are reduced significantly; (4) The forecasted floods are close to the observations as evaluated by three measures: the normalized total flow outside the uncertainty intervals (FOUI), average relative band-width (RB) and average deviation amplitude (D). The flood forecasting uncertainty is also reduced a lot with ɛ-NSGAII based sampling. This study provides a new sampling approach to improve multiple metrics uncertainty analysis under the framework of GLUE, and could be used to reveal the underlying mechanisms of parameter sets under multiple conflicting metrics in the uncertainty analysis process.

  17. A direct approach to generalised multiple mapping conditioning for selected turbulent diffusion flame cases

    Science.gov (United States)

    Sundaram, Brruntha; Klimenko, Alexander Yuri; Cleary, Matthew John; Ge, Yipeng

    2016-07-01

    This work presents a direct and transparent interpretation of two concepts for modelling turbulent combustion: generalised Multiple Mapping Conditioning (MMC) and sparse-Lagrangian Large Eddy Simulation (LES). The MMC approach is presented as a hybrid between the Probability Density Function (PDF) method and approaches based on conditioning (e.g. Conditional Moment Closure, flamelet, etc.). The sparse-Lagrangian approach, which allows for a dramatic reduction of computational cost, is viewed as an alternative interpretation of the Filtered Density Function (FDF) methods. This work presents simulations of several turbulent diffusion flame cases and discusses the universality of the localness parameter between these cases and the universality of sparse-Lagrangian FDF methods with MMC.

  18. Surgical approach in patients with hyperparathyroidism in multiple endocrine neoplasia type 1: total versus partial parathyroidectomy

    Directory of Open Access Journals (Sweden)

    Francesco Tonelli

    2012-01-01

    Full Text Available Usually, primary hyperparathyroidism is the first endocrinopathy to be diagnosed in patients with multiple endocrine neoplasia type 1, and is also the most common one. The timing of the surgery and strategy in multiple endocrine neoplasia type 1/hyperparathyroidism are still under debate. The aims of surgery are to: 1 correct hypercalcemia, thus preventing persistent or recurrent hyperparathyroidism; 2 avoid persistent hypoparathyroidism; and 3 facilitate the surgical treatment of possible recurrences. Currently, two types of surgical approach are indicated: 1 subtotal parathyroidectomy with removal of at least 3-3 K glands; and 2 total parathyroidectomy with grafting of autologous parathyroid tissue. Transcervical thymectomy must be performed with both of these procedures. Unsuccessful surgical treatment of hyperparathyroidism is more frequently observed in multiple endocrine neoplasia type 1 than in sporadic hyperparathyroidism. The recurrence rate is strongly influenced by: 1 the lack of a pre-operative multiple endocrine neoplasia type 1 diagnosis; 2 the surgeon's experience; 3 the timing of surgery; 4 the possibility of performing intra-operative confirmation (histologic examination, rapid parathyroid hormone assay of the curative potential of the surgical procedure; and, 5 the surgical strategy. Persistent hyperparathyroidism seems to be more frequent after subtotal parathyroidectomy than after total parathyroidectomy with autologous graft of parathyroid tissue. Conversely, recurrent hyperparathyroidism has a similar frequency in the two surgical strategies. To plan further operations, it is very helpful to know all the available data about previous surgery and to undertake accurate identification of the site of recurrence.

  19. Identification of Biomarkers in Cerebrospinal Fluid and Serum of Multiple Sclerosis Patients by Immunoproteomics Approach

    Directory of Open Access Journals (Sweden)

    Paolo Colomba

    2014-12-01

    Full Text Available Multiple sclerosis (MS is an autoimmune inflammatory demyelinating disease of the central nervous system. At present, the molecular mechanisms causing the initiation, development and progression of MS are poorly understood, and no reliable proteinaceous disease markers are available. In this study, we used an immunoproteomics approach to identify autoreactive antibodies in the cerebrospinal fluid of MS patients to use as candidate markers with potential diagnostic value. We identified an autoreactive anti-transferrin antibody that may have a potential link with the development and progression of MS. We found this antibody at high levels also in the serum of MS patients and created an immunoenzymatic assay to detect it. Because of the complexity and heterogeneity of multiple sclerosis, it is difficult to find a single marker for all of the processes involved in the origin and progression of the disease, so the development of a panel of biomarkers is desirable, and anti-transferrin antibody could be one of these.

  20. Triaging multiple victims in an avalanche setting: the Avalanche Survival Optimizing Rescue Triage algorithmic approach.

    Science.gov (United States)

    Bogle, Lee B; Boyd, Jeff J; McLaughlin, Kyle A

    2010-03-01

    As winter backcountry activity increases, so does exposure to avalanche danger. A complicated situation arises when multiple victims are caught in an avalanche and where medical and other rescue demands overwhelm resources in the field. These mass casualty incidents carry a high risk of morbidity and mortality, and there is no recommended approach to patient care specific to this setting other than basic first aid principles. The literature is limited with regard to triaging systems applicable to avalanche incidents. In conjunction with the development of an electronic avalanche rescue training module by the Canadian Avalanche Association, we have designed the Avalanche Survival Optimizing Rescue Triage algorithm to address the triaging of multiple avalanche victims to optimize survival and disposition decisions.

  1. Multiple Stressors and Ecological Complexity Require A New Approach to Coral Reef Research

    Directory of Open Access Journals (Sweden)

    Linwood Hagan Pendleton

    2016-03-01

    Full Text Available Ocean acidification, climate change, and other environmental stressors threaten coral reef ecosystems and the people who depend upon them. New science reveals that these multiple stressors interact and may affect a multitude of physiological and ecological processes in complex ways. The interaction of multiple stressors and ecological complexity may mean that the negative effects on coral reef ecosystems will happen sooner and be more severe than previously thought. Yet, most research on the effects of global change on coral reefs focus on one or few stressors and pathways or outcomes (e.g. bleaching. Based on a critical review of the literature, we call for a regionally targeted strategy of mesocosm-level research that addresses this complexity and provides more realistic projections about coral reef impacts in the face of global environmental change. We believe similar approaches are needed for other ecosystems that face global environmental change.

  2. Multiple, sclerosis: clinical feature, pathogenesis and current therapeutical approaches; Encephalomyelitis disseminata: Klinik, Pathogenese und aktuelle Therapiekonzepte

    Energy Technology Data Exchange (ETDEWEB)

    Merkelbach, S.; Koelmel, C.; Schimrigk, K. [Universitaet des Saarlandes, Homburg/Saar (Germany). Neurologische Klinik

    2000-11-01

    Multiple sclerosis (MS) is considered as a T-cell mediated autoimmune disease. Caused by central nervous system demyelination and axonal damage varying clinical signs do occur either with relapsing-remitting or with chronic progressive course. Based on pathogenetic considerations immunomodulative and immunosuppressive therapeutical approaches are used to limit the disease progression. Clinical symptoms, diagnostic criteria, pathogenetical considerations, and consecutive therapeutical interventions are summarized. (orig.) [German] Die Encephalomyelitis disseminata oder Multiple Sklerose (ED oder MS) gilt als T-Zell-vermittelte Autoimmunerkrankung. Schubfoermig oder chronisch progredient kommt es im Zentralnervensystem infolge einer Demyelinisierung der weissen Substanz und axonaler Schaedigungen zu einer Vielzahl neurologischer Symptome. Basierend auf pathogenetischen Erkenntnissen werden derzeit immunmodulative und immunsuppressive Therapien eingesetzt, die den Krankheitsverlauf zumindest bremsen. Klinische Symptome, diagnostische Kriterien, pathogenetische Ueberlegungen und sich daraus ableitende Therapiekonzepte werden zusammenfassend dargestellt. (orig.)

  3. Multiple emotions: a person-centered approach to the relationship between intergroup emotion and action orientation.

    Science.gov (United States)

    Fernando, Julian W; Kashima, Yoshihisa; Laham, Simon M

    2014-08-01

    Although a great deal of research has investigated the relationship between emotions and action orientations, most studies to date have used variable-centered techniques to identify the best emotion predictor(s) of a particular action. Given that people frequently report multiple or blended emotions, a profitable area of research may be to adopt person-centered approaches to examine the action orientations elicited by a particular combination of emotions or "emotion profile." In two studies, across instances of intergroup inequality in Australia and Canada, we examined participants' experiences of six intergroup emotions: sympathy, anger directed at three targets, shame, and pride. In both studies, five groups of participants with similar emotion profiles were identified by cluster analysis and their action orientations were compared; clusters indicated that the majority of participants experienced multiple emotions. Each action orientation was also regressed on the six emotions. There were a number of differences in the results obtained from the person-centered and variable-centered approaches. This was most apparent for sympathy: the group of participants experiencing only sympathy showed little inclination to perform prosocial actions, yet sympathy was a significant predictor of numerous action orientations in regression analyses. These results imply that sympathy may only prompt a desire for action when experienced in combination with other emotions. We suggest that the use of person-centered and variable-centered approaches as complementary analytic strategies may enrich research into not only the affective predictors of action, but emotion research in general.

  4. An Application of Graphical Approach to Construct Multiple Testing Procedure in a Hypothetical Phase III Design

    Directory of Open Access Journals (Sweden)

    Naitee eTing

    2014-01-01

    Full Text Available Many multiple testing procedures (MTP have been developed in recent years. Among these new procedures, the graphical approach is flexible and easy to communicate with non-statisticians. A hypothetical Phase III clinical trial design is introduced in this manuscript to demonstrate how graphical approach can be applied in clinical product development. In this design, an active comparator is used. It is thought that this test drug under development could potentially be superior to this comparator. For comparison of efficacy, the primary endpoint is well established and widely accepted by regulatory agencies. However, an important secondary endpoint based on Phase II findings looks very promising. The target dose may have a good opportunity to deliver superiority to the comparator. Furthermore, a lower dose is included in case the target dose may demonstrate potential safety concerns. This Phase III study is designed as a non-inferiority trial with two doses, and two endpoints. This manuscript will illustrate how graphical approach is applied to this design in handling multiple testing issues.

  5. Enhanced understanding of the terrestrial carbon cycle through multiple constraints in model-data-integration approaches

    Science.gov (United States)

    Carvalhais, N.; Forkel, M.; Oijen, M. V.; Keenan, T. F.; MacBean, N.; Rolinski, S.; Peylin, P. P.; Schuermann, G. J.; Zaehle, S.; Reichstein, M.

    2015-12-01

    The representation of exchanges of carbon, water and energy between the land surface and the atmosphere still reveals significant model limitations in explaining temporal and spatial variability. Despite agreement between models for contemporaneous periods, prognostic simulations reveal a strong between-model divergence regarding the role of the land surface in the global carbon cycle. The integration of multiple data-streams in inverse modelling approaches for parameterization and model evaluation, ultimately leads to model improvement. Here we explore multiple-constraint approaches ranging from in situ to regional and global spatial scales. Constraints include stocks and fluxes of water and carbon. We show that integrating multiple datasets contributes to a better representation of ecosystem dynamics in different models, from forest and dynamic vegetation models to land surface schemes. At site scale, model-data comparisons reveal substantial differences in the modelled temporal dynamics of carbon stocks and turnover times and their relationships with climate, especially at annual scales. Inter-annual variability remains a problem for all models, even after parameter optimization. At regional and global scales, the integration of multiple data-streams to constrain albedo, phenology and primary productivity patterns yields a significant improvement in regional simulations of vegetation dynamics, from seasons to longer-term trends. The role of environmental controls and vegetation dynamics in explaining recent trends in the amplitude of the seasonal cycle of atmospheric CO2 is evaluated using an improved dynamic vegetation model. We conclude by identifying major challenges in model-data-integration: to explore the information content in longer time series; avoid confounding effects of missing processes on parameter estimation; set up cost functions for multivariate-data integration; quantification of uncertainties arising from data bias, model structure, and

  6. Esclerosis sistémica complicada con síncope y bloqueo AV completo Systemic sclerosis complicated with syncope and complete AV block

    Directory of Open Access Journals (Sweden)

    Francisco Femenía

    2010-10-01

    Full Text Available La esclerosis sistémica es una compleja enfermedad que afecta el tejido conectivo, el sistema vascular y el sistema inmunológico, y se caracteriza por fibrosis cutánea y de órganos viscerales. Los bloqueos de rama y los hemibloqueos se presentan en el 25 a 75% de los casos y constituyen predictores independientes de mortalidad. Los bloqueos auriculoventriculares de segundo o tercer grado son muy raros. Presentamos el caso de una mujer de 47 años de edad, con diagnóstico de esclerosis sistémica, quien presenta episodio sincopal secundario a bloqueo auriculoventricular completo con necesidad de implante de marcapasos definitivo.Systemic sclerosis is a complex disease that affects the connective tissue, the vascular system and the immune system. It typically produces skin and organ fibrosis. Cardiac bundle branch blocks and fascicular blocks occur in 25-75% of the cases and were found to be independent predictors of mortality. Second and third degree atrioventricular block are very rare. We present the case of a 47 year-old female with diagnosis of systemic sclerosis, presented with syncope secondary to complete atrioventricular block requiring permanent pacemaker implantation.

  7. Caracterización de la esclerosis tuberosa en pacientes que consultan al Hospital Universitario San Vicente de Paúl, Medellín, Colombia

    Directory of Open Access Journals (Sweden)

    Dagoberto Nicanor Cabrera Hémer

    2008-11-01

    Full Text Available La esclerosis tuberosa (ET es una enfermedad autosómica dominante, que afecta muchos sistemas y cursa con diversas manifestaciones clínicas, entre ellas epilepsia, retardo mental y lesiones cutáneas. Se hizo un estudio retrospectivo para contribuir a la caracterización de la esclerosis tuberosa en Medellín, Colombia. Se revisaron 21 historias, 62% mujeres y 38% hombres; la edad media al momento del diagnóstico fue 23 meses, todos los pacientes tenían epilepsia y lesiones cutáneas, las crisis más frecuentes fueron las parciales con generalización secundaria (66%, 47% tuvieron espasmos infantiles, la mayoría presentaron dos o más tipos de crisis (90%. Todos los pacientes recibieron anticonvulsivantes, los más frecuentemente utilizados fueron: fenobarbital, ácido valproico, vigabatrina, carbamazepina y clonazepam. En general, la mayoría de los pacientes requirieron varios medicamentos durante la evolución de su enfermedad y los pocos que lograron un adecuado control de la epilepsia, lo hicieron con anticonvulsivantes de primera generación. CONCLUSIÓN:las características de nuestra serie son similares a las reportadas en la literatura mundial. Los antiepilépticos de primera generación siguen siendo la principal herramienta terapéutica para el tratamiento inicial de los pacientes Medellín.

  8. Different approaches for centralized and decentralized water system management in multiple decision makers' problems

    Science.gov (United States)

    Anghileri, D.; Giuliani, M.; Castelletti, A.

    2012-04-01

    There is a general agreement that one of the most challenging issues related to water system management is the presence of many and often conflicting interests as well as the presence of several and independent decision makers. The traditional approach to multi-objective water systems management is a centralized management, in which an ideal central regulator coordinates the operation of the whole system, exploiting all the available information and balancing all the operating objectives. Although this approach allows to obtain Pareto-optimal solutions representing the maximum achievable benefit, it is based on assumptions which strongly limits its application in real world contexts: 1) top-down management, 2) existence of a central regulation institution, 3) complete information exchange within the system, 4) perfect economic efficiency. A bottom-up decentralized approach seems therefore to be more suitable for real case applications since different reservoir operators may maintain their independence. In this work we tested the consequences of a change in the water management approach moving from a centralized toward a decentralized one. In particular we compared three different cases: the centralized management approach, the independent management approach where each reservoir operator takes the daily release decision maximizing (or minimizing) his operating objective independently from each other, and an intermediate approach, leading to the Nash equilibrium of the associated game, where different reservoir operators try to model the behaviours of the other operators. The three approaches are demonstrated using a test case-study composed of two reservoirs regulated for the minimization of flooding in different locations. The operating policies are computed by solving one single multi-objective optimal control problem, in the centralized management approach; multiple single-objective optimization problems, i.e. one for each operator, in the independent case

  9. Drug induced mortality: a multiple cause approach on Italian causes of death Register

    Directory of Open Access Journals (Sweden)

    Francesco Grippo

    2015-04-01

    Full Text Available Background: Drug-related mortality is a complex phenomenon that has several health, social and economic effects. In this paper trends of drug-induced mortality in Italy are analysed. Two approaches have been followed: the traditional analysis of the underlying cause of death (UC (data refers to the Istat mortality database from 1980 to 2011, and the multiple cause (MCanalysis, that is the analysis of all conditions reported on the death certificate (data for 2003-2011 period.Methods: Data presented in this paper are based on the Italian mortality register. The selection of Icd codes used for the analysis follows the definition of the European Monitoring Centre for Drugs and Drug Addiction. Using different indicators (crude and standardized rates, ratio multiple to underlying, the results obtained from the two approaches (UC and MC have been compared. Moreover, as a measure of association between drug-related causes and specific conditions on the death certificate, an estimation of the age-standardized relative risk (RR has been used.Results: In the years 2009-2011, the total number of certificates whit mention of drug use was 1,293, 60% higher than the number UC based. The groups of conditions more strongly associated with drug-related causes are the mental and behavioral disorders (especially alcohol consumption, viral hepatitis, cirrhosis and fibrosis of liver, AIDS and endocarditis.Conclusions : The analysis based on multiple cause approach shows, for the first time, a more detailed picture of the drug related death; it allows to better describe the mortality profiles and to re-evaluate  the contribution of a specific cause to death.

  10. Attitude control of an object commonly held by multiple robot arms - A Lyapunov approach

    Science.gov (United States)

    Kreutz, Kenneth; Wen, John T.

    1988-01-01

    Multiple robot arms moving a commonly held object can be viewed as complex actuators whose purpose is to provide net forces and moments to the object. These forces and moments can be used to control the orientation, or attitude, of the object via the Euler equation describing attitude evolution in response to applied moments at the mass center. In contrast to the common approach that feedback-linearizes the attitude dynamics to a double integrator form with respect to some three-parameter local representation of orientation, the authors control the object using a globally nonsingular representation. Using an energy-motivated Liapunov function, globally stable control of attitude is shown.

  11. Malformaciones venosas orofaciales de bajo flujo: esclerosis endoluminal con láser de diodo Low-flow orofacial venous malformations: endoluminal sclerosis with a diode laser

    Directory of Open Access Journals (Sweden)

    M. Puche Torres

    2010-06-01

    Full Text Available Introducción: Las anomalías vasculares son procesos frecuentes que se localizan en más del 50% de los casos en la región de la cabeza y el cuello. Las técnicas clásicas de tratamiento, tales como la cirugía y la esclerosis química, han dado paso a modernas técnicas menos invasivas, tales como el láser Nd:YAG. Por otra parte, se ha utilizado con éxito el láser de diodo (980 nm para el tratamiento de varices mediante esclerosis endoluminal. Nuestra propuesta es la utilización del láser de diodo (l 980 nm para provocar una esclerosis por fotocoagulación intralesional de las malformaciones venosas de bajo flujo dada la capacidad de este láser de ser transmitido por fibra óptica. Objetivo: Exponer nuestros resultados en el tratamiento de malformaciones venosas de bajo flujo (MVBF orofaciales mediante la terapéutica de esclerosis endoluminal con láser de diodo. Material y métodos: Revisamos 84 pacientes que presentaban MVBF orofaciales tratados con láser de diodo. Describimos la técnica de realización y se muestran los resultados postoperatorios a corto plazo. Resultados: Tras un periodo de seguimiento no inferior a 12 meses se constató curación en el 95,24% aplicando una o dos sesiones y solamente en 4 casos se objetivó recidiva. Concluimos que la técnica de esclerosis endoluminal con láser de diodo de MVBF en el área orofacial se constituye como una nueva técnica de tratamiento, mínimamente invasiva, ambulatoria, y que permite la resolución de los casos sin tener que recurrir a cirugías más agresivas y con excelentes resultados funcionales y estéticos.Background: Vascular anomalies are common processes that involve the head and neck region in more than 50% of the cases. Traditional treatment options such as surgery and chemical sclerosis have given way to modern less-invasive techniques, including Nd:YAG laser treatment. On the other hand, 980 nm laser diode has been successfully used for the endovenous sclerosis

  12. Hierarchical approach to optimization of parallel matrix multiplication on large-scale platforms

    KAUST Repository

    Hasanov, Khalid

    2014-03-04

    © 2014, Springer Science+Business Media New York. Many state-of-the-art parallel algorithms, which are widely used in scientific applications executed on high-end computing systems, were designed in the twentieth century with relatively small-scale parallelism in mind. Indeed, while in 1990s a system with few hundred cores was considered a powerful supercomputer, modern top supercomputers have millions of cores. In this paper, we present a hierarchical approach to optimization of message-passing parallel algorithms for execution on large-scale distributed-memory systems. The idea is to reduce the communication cost by introducing hierarchy and hence more parallelism in the communication scheme. We apply this approach to SUMMA, the state-of-the-art parallel algorithm for matrix–matrix multiplication, and demonstrate both theoretically and experimentally that the modified Hierarchical SUMMA significantly improves the communication cost and the overall performance on large-scale platforms.

  13. Prediction Approach of Critical Node Based on Multiple Attribute Decision Making for Opportunistic Sensor Networks

    Directory of Open Access Journals (Sweden)

    Qifan Chen

    2016-01-01

    Full Text Available Predicting critical nodes of Opportunistic Sensor Network (OSN can help us not only to improve network performance but also to decrease the cost in network maintenance. However, existing ways of predicting critical nodes in static network are not suitable for OSN. In this paper, the conceptions of critical nodes, region contribution, and cut-vertex in multiregion OSN are defined. We propose an approach to predict critical node for OSN, which is based on multiple attribute decision making (MADM. It takes RC to present the dependence of regions on Ferry nodes. TOPSIS algorithm is employed to find out Ferry node with maximum comprehensive contribution, which is a critical node. The experimental results show that, in different scenarios, this approach can predict the critical nodes of OSN better.

  14. [Optic neuritis in childhood. A pediatric series, literature review and treatment approach].

    Science.gov (United States)

    Lopez-Martin, D; Martinez-Anton, J

    2016-08-01

    Introduccion. En la edad pediatrica, la forma mas frecuente de neuritis optica se presenta generalmente despues de un cuadro infeccioso, con edema de papila, que suele ser bilateral y tiene buen pronostico. La conversion a esclerosis multiple es infrecuente. Objetivo. Presentar las caracteristicas clinicas y de laboratorio de una serie pediatrica de neuritis optica. Pacientes y metodos. Se analiza una serie de 17 casos de neuritis optica en niños y jovenes de 4 a 14 años, referidos entre los años 2000 y 2015. Resultados. La edad mediana de la serie fue de 11 años. Predominaron los pacientes de sexo femenino y el antecedente infeccioso fue poco frecuente; en cinco pacientes, la afectacion fue bilateral, y cuatro casos se presentaron como neuritis optica retrobulbar. La resonancia magnetica mostro hiperintensidad en T2 en los nervios opticos afectados en cinco pacientes. El estudio del liquido cefalorraquideo y bandas oligoclonales fue normal en todos los casos. Los pacientes, tratados con metilprednisolona intravenosa, tuvieron buena recuperacion. Solo en tres casos se comprobo una evolucion posterior a esclerosis multiple. Conclusiones. En esta serie, los casos que evolucionaron a esclerosis multiple no mostraron diferencias clinicas, aunque si presentaron mayor cantidad de lesiones hiperintensas en la resonancia magnetica. Este hecho, descrito en trabajos previos, apoya nuestro esquema diagnostico y terapeutico en un intento por acercarnos al manejo optimo de esta patologia.

  15. Why is the Arkavathy River drying? A multiple hypothesis approach in a data scarce region

    Directory of Open Access Journals (Sweden)

    V. Srinivasan

    2015-01-01

    Full Text Available The developing world faces unique challenges in achieving water security as it is disproportionately exposed to stressors such as climate change while also undergoing demographic growth, agricultural intensification and industrialization. Investigative approaches are needed that can inform sound policy development and planning to address the water security challenge in the context of data scarcity. We investigated the "predictions under change" problem in the Thippagondanahalli (TG Halli catchment of the Arkavathy sub-basin in South India. River inflows into the TG Halli reservoir have declined since the 1970s, and the reservoir is currently operating at only 20% of its built capacity. The mechanisms responsible for the drying of the river are not understood, resulting in uncoordinated and potentially counter-productive management responses. The objective of this study was to investigate potential explanations of the drying trend and thus obtain predictive insight. We used a multiple working hypothesis approach to investigate the decline in inflow into TG Halli reservoir. Five hypotheses were tested using data from field surveys and reliable secondary sources: (1 changes in rainfall amount, timing and storm intensity, (2 rising temperatures, (3 increased groundwater extraction, (4 expansion of eucalyptus plantations, and (5 increased fragmentation of the river channel. Our results indicate that proximate anthropogenic drivers of change such as groundwater pumping, expansion of eucalyptus plantations, and to a lesser extent channel fragmentation, are much more likely to have caused the decline in surface flows in the TG Halli catchment than changing climate. The case study shows that direct human interventions play a significant role in altering the hydrology of watersheds. The multiple working hypotheses approach presents a systematic way to quantify the relative contributions of anthropogenic drivers to hydrologic change. The approach not only

  16. Full-field illumination approach with multiple speckle for optical-resolution photoacoustic microscopy (Conference Presentation)

    Science.gov (United States)

    Poisson, Florian; Bossy, Emmanuel

    2016-03-01

    Optical-resolution photoacoustic endomicroscopy (OR-PAE) allows going beyond the limited penetration depth of conventional optical-resolution photoacoustic systems. Recently, it has been shown that OR-PAE may be performed through minimally invasive multimode fibers, by raster scanning a focus spot with optical wavefront shaping [1]. Here we introduce for the first time an approach to perform OR-PAE through a multimode fiber with a full-field illumination approach. By using multiple known speckle patterns, we show that it is possible to obtain optical-diffraction limited photoacoustic images, with the same resolution as that obtained by raster scanning a focus spot, i.e that of the speckle grain size. The fluctuations patterns of the photoacoustic amplitude at each pixel in the sample plane with the series of multiple speckle illumination were used to encode each pixel. This approach with known speckle illumination requires an initial calibration stage, that consists in learn a set of fluctuation patterns pixel per pixel, which will encode patterns each pixel of the scanned area. A point-like absorber was scanned across the filed-of-view during the calibration stage to acquire the reference patterns. Image reconstruction may be carried out by cross-correlating the series of photoacoustic amplitude measured with the sample to the reference patterns obtained during the calibration stage. In this work, the approach above was carried out both theoretically with Monte-carlo simulations and experimentally through a multi-mode fiber with samples made of absorbing spheres. [1] Papadopoulos et al., " Optical-resolution photoacoustic microscopy by use of a multimode fiber", Appl. Phys. Lett., 102(21), 2013

  17. A Systems Engineering Approach to Multiple Attribute Utility Theory and Multiple Objective Optimization Theory: With Application To Aircraft Retrofit Design.

    Science.gov (United States)

    1980-01-01

    Keeney, R., Sicherman, A., "An Interactive Computer Program for Assess- ing and Analyzing Preferences Concerning Multiple Objectives," IIASA ...With Cardinal Utility," ,Management Science, Vol. 23, No. 2, Oct., 1976a. Keeney, R.L., "Energy Policy and Value Tradeoffs," IIASA , Report RM-75-76...Objectives," IIASA , Schloss Laxenburg, Austria, April, 1975. Keeney, R.L., Raiffa, H., Decisions With Multiple Objectives: Prefer- ences and Value

  18. AN EFFECTIVE MULTIPLE CRITERIA APPROACH TO INFRASTRUCTURE RECONSTRUCTION IN DEVASTATED COUNTRIES

    Institute of Scientific and Technical Information of China (English)

    K.A.NIGIM; K.W.HIPEL; G.B.SMITH

    2006-01-01

    Infrastructure facilities in many countries have been repeatedly subjected to natural or human-induced disasters. International aid institutions, such as the United Nations Development Program (UNDP), United States Aid International Development (USAID), Japan International Cooperation Agency (JICA) and the World Bank International Aid Development (IDA), are endeavoring to assist in the reconstruction of devastated countries. Development institutions normally face the problem of selecting and implementing relevant priority infrastructure projects that are needed in various sectors. Usually there are also several key local players in the decision making process. In many cases, these main decision makers have contradictory objectives that lead to conflict and thereby hamper the reconstruction process. In response to this kind of problem, an effective approach has been developed within the field of Multiple Criteria Decision Analysis (MCDA), the Analytical Hierarchy Process (AHP), that can assist decision makers in prioritizing projects to meet specified goals and objectives. Using the AHP approach, the problem of selecting infrastructure projects is dealt with systematically when applying this flexible MCDA technique. This approach takes into account possible uncertainties and social discrepancies, and can use the judgments of the decision makers themselves when there is a lack of technical or historical data. Decision makers from international financial aid institutions, donor agencies, governmental and the local community can utilize this proposed approach.

  19. Integrated health messaging for multiple neglected zoonoses: Approaches, challenges and opportunities in Morocco.

    Science.gov (United States)

    Ducrotoy, M J; Yahyaoui Azami, H; El Berbri, I; Bouslikhane, M; Fassi Fihri, O; Boué, F; Petavy, A F; Dakkak, A; Welburn, S; Bardosh, K L

    2015-12-01

    Integrating the control of multiple neglected zoonoses at the community-level holds great potential, but critical data is missing to inform the design and implementation of different interventions. In this paper we present an evaluation of an integrated health messaging intervention, using powerpoint presentations, for five bacterial (brucellosis and bovine tuberculosis) and dog-associated (rabies, cystic echinococcosis and leishmaniasis) zoonotic diseases in Sidi Kacem Province, northwest Morocco. Conducted by veterinary and epidemiology students between 2013 and 2014, this followed a process-based approach that encouraged sequential adaptation of images, key messages, and delivery strategies using auto-evaluation and end-user feedback. We describe the challenges and opportunities of this approach, reflecting on who was targeted, how education was conducted, and what tools and approaches were used. Our results showed that: (1) replacing words with local pictures and using "hands-on" activities improved receptivity; (2) information "overload" easily occurred when disease transmission pathways did not overlap; (3) access and receptivity at schools was greater than at the community-level; and (4) piggy-backing on high-priority diseases like rabies offered an important avenue to increase knowledge of other zoonoses. We conclude by discussing the merits of incorporating our validated education approach into the school curriculum in order to influence long-term behaviour change.

  20. Estimating variable effective population sizes from multiple genomes: a sequentially markov conditional sampling distribution approach.

    Science.gov (United States)

    Sheehan, Sara; Harris, Kelley; Song, Yun S

    2013-07-01

    Throughout history, the population size of modern humans has varied considerably due to changes in environment, culture, and technology. More accurate estimates of population size changes, and when they occurred, should provide a clearer picture of human colonization history and help remove confounding effects from natural selection inference. Demography influences the pattern of genetic variation in a population, and thus genomic data of multiple individuals sampled from one or more present-day populations contain valuable information about the past demographic history. Recently, Li and Durbin developed a coalescent-based hidden Markov model, called the pairwise sequentially Markovian coalescent (PSMC), for a pair of chromosomes (or one diploid individual) to estimate past population sizes. This is an efficient, useful approach, but its accuracy in the very recent past is hampered by the fact that, because of the small sample size, only few coalescence events occur in that period. Multiple genomes from the same population contain more information about the recent past, but are also more computationally challenging to study jointly in a coalescent framework. Here, we present a new coalescent-based method that can efficiently infer population size changes from multiple genomes, providing access to a new store of information about the recent past. Our work generalizes the recently developed sequentially Markov conditional sampling distribution framework, which provides an accurate approximation of the probability of observing a newly sampled haplotype given a set of previously sampled haplotypes. Simulation results demonstrate that we can accurately reconstruct the true population histories, with a significant improvement over the PSMC in the recent past. We apply our method, called diCal, to the genomes of multiple human individuals of European and African ancestry to obtain a detailed population size change history during recent times.

  1. Precise segmentation of multiple organs in CT volumes using learning-based approach and information theory.

    Science.gov (United States)

    Lu, Chao; Zheng, Yefeng; Birkbeck, Neil; Zhang, Jingdan; Kohlberger, Timo; Tietjen, Christian; Boettger, Thomas; Duncan, James S; Zhou, S Kevin

    2012-01-01

    In this paper, we present a novel method by incorporating information theory into the learning-based approach for automatic and accurate pelvic organ segmentation (including the prostate, bladder and rectum). We target 3D CT volumes that are generated using different scanning protocols (e.g., contrast and non-contrast, with and without implant in the prostate, various resolution and position), and the volumes come from largely diverse sources (e.g., diseased in different organs). Three key ingredients are combined to solve this challenging segmentation problem. First, marginal space learning (MSL) is applied to efficiently and effectively localize the multiple organs in the largely diverse CT volumes. Second, learning techniques, steerable features, are applied for robust boundary detection. This enables handling of highly heterogeneous texture pattern. Third, a novel information theoretic scheme is incorporated into the boundary inference process. The incorporation of the Jensen-Shannon divergence further drives the mesh to the best fit of the image, thus improves the segmentation performance. The proposed approach is tested on a challenging dataset containing 188 volumes from diverse sources. Our approach not only produces excellent segmentation accuracy, but also runs about eighty times faster than previous state-of-the-art solutions. The proposed method can be applied to CT images to provide visual guidance to physicians during the computer-aided diagnosis, treatment planning and image-guided radiotherapy to treat cancers in pelvic region.

  2. An objective-oriented approach to program comprehension using multiple information sources

    Institute of Scientific and Technical Information of China (English)

    ZHAO Wei; ZHANG Lu; SUN JiaSu; MEI Hong

    2008-01-01

    Program comprehension is a key activity throughout software maintenance and reuse.The knowledge acquired through comprehending programs can guide en-gineers to perform various kinds of software maintenance and reuse tasks.The effective comprehension strategy and the associated efficient approach,as well as the sophisticated tool support,are the indispensable elements for an entire solu-tion to program comprehension to reduce the high costs of this nontrivial activity.This paper presents an objective-oriented comprehension strategy,contrasting to the traditional comprehensive understanding strategy in the literature.It is a kind of on-demand understanding for specific tasks and more effective in practice.In ad-dition,using multiple information sources to understand programs is proposed with the corresponding framework.From these two points of views,we propose a feature-oriented program comprehension approach using requirement documenta-tion.This approach aims at a specific category of feature-related software mainte-nance and reuse tasks.Case studies are conducted to evaluate the proposed solu-tion.Results from the studied cases show that the experimental prototype provides more explicit advices for software engineers when performing these tasks.

  3. Fine Surveying and 3D Modeling Approach for Wooden Ancient Architecture via Multiple Laser Scanner Integration

    Directory of Open Access Journals (Sweden)

    Qingwu Hu

    2016-03-01

    Full Text Available A multiple terrestrial laser scanner (TLS integration approach is proposed for the fine surveying and 3D modeling of ancient wooden architecture in an ancient building complex of Wudang Mountains, which is located in very steep surroundings making it difficult to access. Three-level TLS with a scalable measurement distance and accuracy is presented for data collection to compensate for data missed because of mutual sheltering and scanning view limitations. A multi-scale data fusion approach is proposed for data registration and filtering of the different scales and separated 3D data. A point projection algorithm together with point cloud slice tools is designed for fine surveying to generate all types of architecture maps, such as plan drawings, facade drawings, section drawings, and doors and windows drawings. The section drawings together with slicing point cloud are presented for the deformation analysis of the building structure. Along with fine drawings and laser scanning data, the 3D models of the ancient architecture components are built for digital management and visualization. Results show that the proposed approach can achieve fine surveying and 3D documentation of the ancient architecture within 3 mm accuracy. In addition, the defects of scanning view and mutual sheltering can overcome to obtain the complete and exact structure in detail.

  4. INCLUSION OF CHILDREN WITH INTELLECTUAL AND MULTIPLE DISABILITIES: A COMMUNITY-BASED REHABILITATION APPROACH, INDIA

    Directory of Open Access Journals (Sweden)

    Ram LAKHAN

    2013-03-01

    Full Text Available Background: Inclusion of children with intellectual disabilities (ID and multiple disabilities (MD in regular schools in India is extremely poor. One of the key objectives of community-based rehabilitation (CBR is to include ID & MD children in regular schools. This study attempted to find out association with age, ID severity, poverty, gender, parent education, population, and multiple disabilities comprising one or more disorders cerebral palsy, epilepsy and psychiatric disorders with inclusion among 259 children in Barwani Block of Barwani District in the state of Madhya Pradesh, India.Aim: Inclusion of children with intellectual and multiple disabilities in regular schools through CBR approach in India.Method: Chi square test was conducted to investigate association between inclusion and predictor variables ID categories, age, gender, poverty level, parent education, population type and multiple disabilities. Result: Inclusion was possible for borderline 2(66.4%, mild 54(68.3%, moderate 18(18.2%, and age range from 5 to 12 years 63 (43%. Children living in poor families 63 (30.6%, not poor 11(18.9%, parental edu­ca­ti­on none 52 (26%, primary level 11 (65%, midd­le school 10 (48% high school 0 (0% and bachelor degree 1(7%, female 34 (27.9%, male 40 (29.2%, tribal 40 (28.7%, non-tribal 34(28.3% and multiple disabled with cerebral palsy 1(1.2%, epilepsy 3 (4.8% and psychiatry disorders 12 (22.6% were able to receive inclusive education. Sig­ni­ficant difference in inclusion among ID ca­te­gories (c2=99.8, p < 0.001, poverty (c2=3.37, p 0.044, parental education (c2=23.7, p < 0.001, MD CP (c2=43.9, p < 0.001 and epilepsy (c2=22.4, p < 0.001 were seen.Conclusion: Inclusion through CBR is feasible and acceptable in poor rural settings in India. CBR can facilitate inclusion of children with borderline, mild and moderate categories by involving their parents, teachers and community members.

  5. Comparing partial least square approaches in a gene- or region-based association study for multiple quantitative phenotypes.

    Science.gov (United States)

    Yuan, Zhongshang; Zhang, Xiaoshuai; Li, Fangyu; Zhao, Jinghua; Xue, Fuzhong

    2014-01-01

    On thinking quantitatively of complex diseases, there are at least three statistical strategies for association studies: one single-nucleotide polymorphism (SNP) on a single trait, gene or region (with multiple SNPs) on a single trait, and gene or region on multiple traits. The third approach is the most general in dissecting genetic mechanisms underlying complex diseases underpinning multiple quantitative traits. Gene or region association methods based on partial least square (PLS) approaches have been shown to have apparent power advantage. However, few approaches have been developed for multiple quantitative phenotypes or traits underlying a condition or disease, and the performance of various PLS approaches used in association studies for multiple quantitative traits have not been assessed. Here we exploit association between multiple SNPs and multiple phenotypes or traits, from a regression perspective, through exhaustive scan statistics (sliding window) using PLS and sparse PLS regressions. Simulations were conducted to assess the performance of the proposed scan statistics and compare them with existing methods. The proposed methods were applied to 12 regions of genome-wide association study data from the European Prospective Investigation of Cancer-Norfolk study.

  6. Diffuse Interface Methods for Multiple Phase Materials: An Energetic Variational Approach

    CERN Document Server

    Brannick, J; Qian, T; Sun, H

    2014-01-01

    In this paper, we introduce a diffuse interface model for describing the dynamics of mixtures involving multiple (two or more) phases. The coupled hydrodynamical system is derived through an energetic variational approach. The total energy of the system includes the kinetic energy and the mixing (interfacial) energies. The least action principle (or the principle of virtual work) is applied to derive the conservative part of the dynamics, with a focus on the reversible part of the stress tensor arising from the mixing energies. The dissipative part of the dynamics is then introduced through a dissipation function in the energy law, in line with the Onsager principle of least energy dissipation. The final system, formed by a set of coupled time-dependent partial differential equations, reflects a balance among various conservative and dissipative forces and governs the evolution of velocity and phase fields. To demonstrate the applicability of the proposed model, a few two-dimensional simulations have been car...

  7. Local Action Groups and Rural Sustainable Development. A spatial multiple criteria approach for efficient territorial planning

    DEFF Research Database (Denmark)

    Palmisano, Giovanni Ottomano; Govindan, M.E., PhD.,, Kannan; Boggia, Antonio

    2016-01-01

    Rural Sustainable Development is a very important topic under the European Union policy, and it is currently promoted through the European Agricultural Fund for Rural Development 2014–2020. This fund is managed at sub-regional level by the Community-Led Local Development approach that involves...... Local Action Groups in order to promote the objectives of Rural Sustainable Development within rural municipalities. Each Local Action Group applies the Strengths, Weaknesses, Opportunities and Threats analysis in order to identify for its own rural municipalities the strategic elements to which...... of their rural municipalities, and therefore to aid the identification of a common Rural Sustainable Development strategy to allocate the European Agricultural Fund for Rural Development budget. This decision problem was tackled by applying a Multiple Criteria Spatial Decision Support System that integrates...

  8. An efficient multiple particle filter based on the variational Bayesian approach

    KAUST Repository

    Ait-El-Fquih, Boujemaa

    2015-12-07

    This paper addresses the filtering problem in large-dimensional systems, in which conventional particle filters (PFs) remain computationally prohibitive owing to the large number of particles needed to obtain reasonable performances. To overcome this drawback, a class of multiple particle filters (MPFs) has been recently introduced in which the state-space is split into low-dimensional subspaces, and then a separate PF is applied to each subspace. In this paper, we adopt the variational Bayesian (VB) approach to propose a new MPF, the VBMPF. The proposed filter is computationally more efficient since the propagation of each particle requires generating one (new) particle only, while in the standard MPFs a set of (children) particles needs to be generated. In a numerical test, the proposed VBMPF behaves better than the PF and MPF.

  9. Optimal investment under multiple defaults risk: a BSDE-decomposition approach

    CERN Document Server

    Jiao, Ying; Pham, Huyên

    2011-01-01

    We study an optimal investment problem under contagion risk in a financial model subject to multiple jumps and defaults. The global market information is formulated as progressive enlargement of a default-free Brownian filtration, and the dependence of default times is modelled by a conditional density hypothesis. In this It\\^o-jump process model, we give a decomposition of the corresponding stochastic control problem into stochastic control problems in the default-free filtration, which are determined in a backward induction. The dynamic programming method leads to a backward recursive system of quadratic Backward Stochastic Differential Equations (BSDEs) in Brownian filtration, and our main result is to prove under fairly general conditions the existence and uniqueness of a solution to this system, which characterizes explicitly the value function and optimal strategies to the optimal investment problem. We illustrate our solutions approach with some numerical tests emphasizing the impact of default intensi...

  10. A Coordinated Approach to Channel Estimation in Large-scale Multiple-antenna Systems

    CERN Document Server

    Yin, Haifan; Filippou, Miltiades; Liu, Yingzhuang

    2012-01-01

    This paper addresses the problem of channel estimation in multi-cell interference-limited cellular networks. We consider systems employing multiple antennas and are interested in both the finite and large-scale antenna number regimes (so-called "Massive MIMO"). Such systems deal with the multi-cell interference by way of per-cell beamforming applied at each base station. Channel estimation in such networks, which is known to be hampered by the pilot contamination effect, constitute a major bottleneck for overall performance. We present a novel approach which tackles this problem by enabling a low-rate coordination between cells during the channel estimation phase itself. The coordination makes use of the additional second-order statistical information about the user channels, which are shown to offer a powerful way of discriminating across interfering users with even strongly correlated pilot sequences. Importantly, we demonstrate analytically that in the large number of antennas regime the pilot contaminatio...

  11. A multivariate partial least squares approach to joint association analysis for multiple correlated traits

    Institute of Scientific and Technical Information of China (English)

    Yang Xu; Wenming Hu; Zefeng Yang; Chenwu Xu

    2016-01-01

    Many complex traits are highly correlated rather than independent. By taking the correlation structure of multiple traits into account, joint association analyses can achieve both higher statistical power and more accurate estimation. To develop a statistical approach to joint association analysis that includes allele detection and genetic effect estimation, we combined multivariate partial least squares regression with variable selection strategies and selected the optimal model using the Bayesian Information Criterion (BIC). We then performed extensive simulations under varying heritabilities and sample sizes to compare the performance achieved using our method with those obtained by single-trait multilocus methods. Joint association analysis has measurable advantages over single-trait methods, as it exhibits superior gene detection power, especially for pleiotropic genes. Sample size, heritability, polymorphic information content (PIC), and magnitude of gene effects influence the statistical power, accuracy and precision of effect estimation by the joint association analysis.

  12. A multivariate partial least squares approach to joint association analysis for multiple correlated traits

    Institute of Scientific and Technical Information of China (English)

    Yang Xu; Wenming Hu; Zefeng Yang; Chenwu Xu

    2016-01-01

    Many complex traits are highly correlated rather than independent. By taking the correlation structure of multiple traits into account, joint association analyses can achieve both higher statistical power and more accurate estimation. To develop a statistical approach to joint association analysis that includes allele detection and genetic effect estimation, we combined multivariate partial least squares regression with variable selection strategies and selected the optimal model using the Bayesian Information Criterion(BIC). We then performed extensive simulations under varying heritabilities and sample sizes to compare the performance achieved using our method with those obtained by single-trait multilocus methods. Joint association analysis has measurable advantages over single-trait methods, as it exhibits superior gene detection power, especially for pleiotropic genes. Sample size, heritability,polymorphic information content(PIC), and magnitude of gene effects influence the statistical power, accuracy and precision of effect estimation by the joint association analysis.

  13. Exploring finite density QCD phase transition with canonical approach -Power of multiple precision computation-

    CERN Document Server

    Oka, Shotaro

    2015-01-01

    The canonical approach for finite density lattice QCD has a numerical instability. This instability makes it difficult to use the method reliably at the finite real chemical potential region. We studied this instability in detail and found that it is caused by the cancellation of significant digits. In order to reduce the effect of this cancellation, we adopt the multiple precision calculation for our discrete Fourier transformation (DFT) program, and we get the canonical partition function Zc(n,T) with required accuracy. From the obtained Zc(n,T), we calculate Lee--Yang zero distribution varying the number of significant digits. As a result, some curves surround the origin in the fugacity plane, but they are moved by varying the number of significant digits. Hence, we conclude that these curves are pseudo phase transition lines, and not real ones.

  14. Material Selection for Dye Sensitized Solar Cells Using Multiple Attribute Decision Making Approach

    Directory of Open Access Journals (Sweden)

    Sarita Baghel

    2014-01-01

    Full Text Available Dye sensitized solar cells (DSCs provide a potential alternative to conventional p-n junction photovoltaic devices. The semiconductor thin film plays a crucial role in the working of DSC. This paper aims at formulating a process for the selection of optimum semiconductor material for nanostructured thin film using multiple attribute decision making (MADM approach. Various possible available semiconducting materials and their properties like band gap, cost, mobility, rate of electron injection, and static dielectric constant are considered and MADM technique is applied to select the best suited material. It was found that, out of all possible candidates, titanium dioxide (TiO2 is the best semiconductor material for application in DSC. It was observed that the proposed results are in good agreement with the experimental findings.

  15. Multiple Triangulation Analysis: another approach to determine the orientation of magnetic flux ropes

    Directory of Open Access Journals (Sweden)

    X.-Z. Zhou

    2006-07-01

    Full Text Available Another approach (Multiple Triangulation Analysis, MTA is presented to determine the orientation of magnetic flux rope, based on 4-point measurements. A 2-D flux rope model is used to examine the accuracy of the MTA technique in a theoretical way. It is found that the precision of the estimated orientation is dependent on both the spacecraft separation and the constellation path relative to the flux rope structure. However, the MTA error range can be shown to be smaller than that of the traditional MVA technique. As an application to real Cluster data, several flux rope events on 26 January 2001 are analyzed using MTA, to obtain their orientations. The results are compared with the ones obtained by several other methods which also yield flux rope orientation. The estimated axis orientations are shown to be fairly close, suggesting the reliability of the MTA method.

  16. A user-friendly forest model with a multiplicative mathematical structure: a Bayesian approach to calibration

    Directory of Open Access Journals (Sweden)

    M. Bagnara

    2014-10-01

    Full Text Available Forest models are being increasingly used to study ecosystem functioning, through the reproduction of carbon fluxes and productivity in very different forests all over the world. Over the last two decades, the need for simple and "easy to use" models for practical applications, characterized by few parameters and equations, has become clear, and some have been developed for this purpose. These models aim to represent the main drivers underlying forest ecosystem processes while being applicable to the widest possible range of forest ecosystems. Recently, it has also become clear that model performance should not be assessed only in terms of accuracy of estimations and predictions, but also in terms of estimates of model uncertainties. Therefore, the Bayesian approach has increasingly been applied to calibrate forest models, with the aim of estimating the uncertainty of their results, and of comparing their performances. Some forest models, considered to be user-friendly, rely on a multiplicative or quasi-multiplicative mathematical structure, which is known to cause problems during the calibration process, mainly due to high correlations between parameters. In a Bayesian framework using a Markov Chain Monte Carlo sampling this is likely to impair the reaching of a proper convergence of the chains and the sampling from the correct posterior distribution. Here we show two methods to reach proper convergence when using a forest model with a multiplicative structure, applying different algorithms with different number of iterations during the Markov Chain Monte Carlo or a two-steps calibration. The results showed that recently proposed algorithms for adaptive calibration do not confer a clear advantage over the Metropolis–Hastings Random Walk algorithm for the forest model used here. Moreover, the calibration remains time consuming and mathematically difficult, so advantages of using a fast and user-friendly model can be lost due to the calibration

  17. Augmenting Tertiary Students' Soft Skills Via Multiple Intelligences Instructional Approach: Literature Courses in Focus

    Directory of Open Access Journals (Sweden)

    El Sherief Eman

    2017-01-01

    Full Text Available The second half of the twentieth century is a witness to an unprecedentedly soaring increase in the number of students joining the arena of higher education(UNESCO,2001. Currently, the number of students at Saudi universities and colleges exceeds one million vis-à-vis 7000 in 1970(Royal Embassy of Saudi Arabia, Washington. Such enormous body of learners in higher education is per se diverse enough to embrace distinct learning styles, assorted repertoire of backgrounds, prior knowledge, experiences, and perspectives; at this juncture, they presumably share common aspiration which is hooking a compatible post in the labor market upon graduation, and to subsequently be capable of acting competently in a scrupulously competitive workplace environment. Bunch of potentialities and skills are patently vital for a graduate to reach such a prospect. Such bunch of skills in a conventional undergraduate paradigm of education were given no heed, being rather postponed to the post-graduation phase. The current Paper postulated tremendous  merits of deploying the Multiple Intelligences theory as a project-based approach, within  literature classes in higher education; a strategy geared towards reigniting students’ engagement, nurturing their critical thinking capabilities, sustaining their individualistic dispositions, molding them as inquiry-seekers, and ending up engendering life-long, autonomous learners,  well-armed with the substantial skills for traversing the rigorous competition in future labor market.  Keywords: Multiple intelligences, teaching Literature, motivation, autonomous learning, critical thinking.

  18. A quantitative approach for integrating multiple lines of evidence for the evaluation of environmental health risks

    Directory of Open Access Journals (Sweden)

    Jerome J. Schleier III

    2015-01-01

    Full Text Available Decision analysis often considers multiple lines of evidence during the decision making process. Researchers and government agencies have advocated for quantitative weight-of-evidence approaches in which multiple lines of evidence can be considered when estimating risk. Therefore, we utilized Bayesian Markov Chain Monte Carlo to integrate several human-health risk assessment, biomonitoring, and epidemiology studies that have been conducted for two common insecticides (malathion and permethrin used for adult mosquito management to generate an overall estimate of risk quotient (RQ. The utility of the Bayesian inference for risk management is that the estimated risk represents a probability distribution from which the probability of exceeding a threshold can be estimated. The mean RQs after all studies were incorporated were 0.4386, with a variance of 0.0163 for malathion and 0.3281 with a variance of 0.0083 for permethrin. After taking into account all of the evidence available on the risks of ULV insecticides, the probability that malathion or permethrin would exceed a level of concern was less than 0.0001. Bayesian estimates can substantially improve decisions by allowing decision makers to estimate the probability that a risk will exceed a level of concern by considering seemingly disparate lines of evidence.

  19. Systematic Analysis of the Multiple Bioactivities of Green Tea through a Network Pharmacology Approach

    Directory of Open Access Journals (Sweden)

    Shoude Zhang

    2014-01-01

    Full Text Available During the past decades, a number of studies have demonstrated multiple beneficial health effects of green tea. Polyphenolics are the most biologically active components of green tea. Many targets can be targeted or affected by polyphenolics. In this study, we excavated all of the targets of green tea polyphenolics (GTPs though literature mining and target calculation and analyzed the multiple pharmacology actions of green tea comprehensively through a network pharmacology approach. In the end, a total of 200 Homo sapiens targets were identified for fifteen GTPs. These targets were classified into six groups according to their related disease, which included cancer, diabetes, neurodegenerative disease, cardiovascular disease, muscular disease, and inflammation. Moreover, these targets mapped into 143 KEGG pathways, 26 of which were more enriched, as determined though pathway enrichment analysis and target-pathway network analysis. Among the identified pathways, 20 pathways were selected for analyzing the mechanisms of green tea in these diseases. Overall, this study systematically illustrated the mechanisms of the pleiotropic activity of green tea by analyzing the corresponding “drug-target-pathway-disease” interaction network.

  20. Unambiguous molecular detections with multiple genetic approach for the complicated chromosome 22q11 deletion syndrome

    Directory of Open Access Journals (Sweden)

    Lin Lung-Huang

    2009-02-01

    Full Text Available Abstract Background Chromosome 22q11 deletion syndrome (22q11DS causes a developmental disorder during the embryonic stage, usually because of hemizygous deletions. The clinical pictures of patients with 22q11DS vary because of polymorphisms: on average, approximately 93% of affected individuals have a de novo deletion of 22q11, and the rest have inherited the same deletion from a parent. Methods using multiple genetic markers are thus important for the accurate detection of these microdeletions. Methods We studied 12 babies suspected to carry 22q11DS and 18 age-matched healthy controls from unrelated Taiwanese families. We determined genomic variance using microarray-based comparative genomic hybridization (array-CGH, quantitative real-time polymerase chain reaction (qPCR and multiplex ligation-dependent probe amplification (MLPA. Results Changes in genomic copy number were significantly associated with clinical manifestations for the classical criteria of 22q11DS using MPLA and qPCR (p Conclusion Both MLPA and qPCR could produce a clearly defined range of deleted genomic DNA, whereas there must be a deleted genome that is not distinguishable using MLPA. These data demonstrate that such multiple genetic approaches are necessary for the unambiguous molecular detection of these types of complicated genomic syndromes.

  1. Statistical Downscaling: A Comparison of Multiple Linear Regression and k-Nearest Neighbor Approaches

    Science.gov (United States)

    Gangopadhyay, S.; Clark, M. P.; Rajagopalan, B.

    2002-12-01

    The success of short term (days to fortnight) streamflow forecasting largely depends on the skill of surface climate (e.g., precipitation and temperature) forecasts at local scales in the individual river basins. The surface climate forecasts are used to drive the hydrologic models for streamflow forecasting. Typically, Medium Range Forecast (MRF) models provide forecasts of large scale circulation variables (e.g. pressures, wind speed, relative humidity etc.) at different levels in the atmosphere on a regular grid - which are then used to "downscale" to the surface climate at locations within the model grid box. Several statistical and dynamical methods are available for downscaling. This paper compares the utility of two statistical downscaling methodologies: (1) multiple linear regression (MLR) and (2) a nonparametric approach based on k-nearest neighbor (k-NN) bootstrap method, in providing local-scale information of precipitation and temperature at a network of stations in the Upper Colorado River Basin. Downscaling to the stations is based on output of large scale circulation variables (i.e. predictors) from the NCEP Medium Range Forecast (MRF) database. Fourteen-day six hourly forecasts are developed using these two approaches, and their forecast skill evaluated. A stepwise regression is performed at each location to select the predictors for the MLR. The k-NN bootstrap technique resamples historical data based on their "nearness" to the current pattern in the predictor space. Prior to resampling a Principal Component Analysis (PCA) is performed on the predictor set to identify a small subset of predictors. Preliminary results using the MLR technique indicate a significant value in the downscaled MRF output in predicting runoff in the Upper Colorado Basin. It is expected that the k-NN approach will match the skill of the MLR approach at individual stations, and will have the added advantage of preserving the spatial co-variability between stations, capturing

  2. Comparing Multiple Intelligences Approach with Traditional Teaching on Eight Grade Students' Achievement in and Attitudes toward Science

    Science.gov (United States)

    Kaya, Osman Nafiz; Dogan, Alev; Gokcek, Nur; Kilic, Ziya; Kilic, Esma

    2007-01-01

    The purpose of this study was to investigate the effects of multiple intelligences (MI) teaching approach on 8th Grade students' achievement in and attitudes toward science. This study used a pretest-posttest control group experimental design. While the experimental group (n=30) was taught a unit on acids and bases using MI teaching approach, the…

  3. Towards ecosystem accounting: a comprehensive approach to modelling multiple hydrological ecosystem services

    Science.gov (United States)

    Duku, C.; Rathjens, H.; Zwart, S. J.; Hein, L.

    2015-10-01

    Ecosystem accounting is an emerging field that aims to provide a consistent approach to analysing environment-economy interactions. One of the specific features of ecosystem accounting is the distinction between the capacity and the flow of ecosystem services. Ecohydrological modelling to support ecosystem accounting requires considering among others physical and mathematical representation of ecohydrological processes, spatial heterogeneity of the ecosystem, temporal resolution, and required model accuracy. This study examines how a spatially explicit ecohydrological model can be used to analyse multiple hydrological ecosystem services in line with the ecosystem accounting framework. We use the Upper Ouémé watershed in Benin as a test case to demonstrate our approach. The Soil Water and Assessment Tool (SWAT), which has been configured with a grid-based landscape discretization and further enhanced to simulate water flow across the discretized landscape units, is used to simulate the ecohydrology of the Upper Ouémé watershed. Indicators consistent with the ecosystem accounting framework are used to map and quantify the capacities and the flows of multiple hydrological ecosystem services based on the model outputs. Biophysical ecosystem accounts are subsequently set up based on the spatial estimates of hydrological ecosystem services. In addition, we conduct trend analysis statistical tests on biophysical ecosystem accounts to identify trends in changes in the capacity of the watershed ecosystems to provide service flows. We show that the integration of hydrological ecosystem services into an ecosystem accounting framework provides relevant information on ecosystems and hydrological ecosystem services at appropriate scales suitable for decision-making.

  4. Guided wave-based identification of multiple cracks in beams using a Bayesian approach

    Science.gov (United States)

    He, Shuai; Ng, Ching-Tai

    2017-02-01

    A guided wave damage identification method using a model-based approach is proposed to identify multiple cracks in beam-like structures. The guided wave propagation is simulated using spectral finite element method and a crack element is proposed to take into account the mode conversion effect. The Bayesian model class selection algorithm is employed to determine the crack number and then the Bayesian statistical framework is used to identify the crack parameters and the associated uncertainties. In order to improve the efficiency and ensure the reliability of identification, the Transitional Markov Chain Monte Carlo (TMCMC) method is implemented in the Bayesian approach. A series of numerical case studies are carried out to assess the performance of the proposed method, in which the sensitivity of different guided wave modes and effect of different levels of measurement noise in identifying different numbers of cracks is studied in detail. The proposed method is also experimentally verified using guided wave data obtained from laser vibrometer. The results show that the proposed method is able to accurately identify the number, locations and sizes of the cracks, and also quantify the associated uncertainties. In addition the proposed method is robust under measurement noise and different situations of the cracks.

  5. A Fisher Kernel Approach for Multiple Instance Based Object Retrieval in Video Surveillance

    Directory of Open Access Journals (Sweden)

    MIRONICA, I.

    2015-11-01

    Full Text Available This paper presents an automated surveillance system that exploits the Fisher Kernel representation in the context of multiple-instance object retrieval task. The proposed algorithm has the main purpose of tracking a list of persons in several video sources, using only few training examples. In the first step, the Fisher Kernel representation describes a set of features as the derivative with respect to the log-likelihood of the generative probability distribution that models the feature distribution. Then, we learn the generative probability distribution over all features extracted from a reduced set of relevant frames. The proposed approach shows significant improvements and we demonstrate that Fisher kernels are well suited for this task. We demonstrate the generality of our approach in terms of features by conducting an extensive evaluation with a broad range of keypoints features. Also, we evaluate our method on two standard video surveillance datasets attaining superior results comparing to state-of-the-art object recognition algorithms.

  6. A heuristic approach using multiple criteria for environmentally benign 3PLs selection

    Science.gov (United States)

    Kongar, Elif

    2005-11-01

    Maintaining competitiveness in an environment where price and quality differences between competing products are disappearing depends on the company's ability to reduce costs and supply time. Timely responses to rapidly changing market conditions require an efficient Supply Chain Management (SCM). Outsourcing logistics to third-party logistics service providers (3PLs) is one commonly used way of increasing the efficiency of logistics operations, while creating a more "core competency focused" business environment. However, this alone may not be sufficient. Due to recent environmental regulations and growing public awareness regarding environmental issues, 3PLs need to be not only efficient but also environmentally benign to maintain companies' competitiveness. Even though an efficient and environmentally benign combination of 3PLs can theoretically be obtained using exhaustive search algorithms, heuristics approaches to the selection process may be superior in terms of the computational complexity. In this paper, a hybrid approach that combines a multiple criteria Genetic Algorithm (GA) with Linear Physical Weighting Algorithm (LPPW) to be used in efficient and environmentally benign 3PLs is proposed. A numerical example is also provided to illustrate the method and the analyses.

  7. Case Studies on an Approach to Multiple Autonomous Vehicle Motion Coordination

    Institute of Scientific and Technical Information of China (English)

    D.K. Liu; X. Wu; G. Paul; G. Dissanayake

    2006-01-01

    This paper conducts a series of case studies on a novel Simultaneous Path and Motion Planning (SiPaMoP) approach[1] to multiple autonomous or Automated Guided Vehicle (AGV) motion coordination in bidirectional networks. The SiPaMoP approach plans collision-free paths for vehicles based on the principle of shortest path by dynamically changing the vehicles' paths, traveling speeds or waiting times, whichever gives the shortest traveling time. It integrates path planning, collision avoidance and motion planning into a comprehensive model and optimizes the vehicles' path and motion to minimize the completion time of a set of tasks. Five case studies, i.e., head-on collision avoidance,catching-up collision avoidance, buffer node generation and collision avoidance, prioritybased motion coordination, and safety distance based planning, are presented. The results demonstrated that the method can effectively plan the path and motion for a team of autonomous vehicles or AGVs, and solve the problems of traffic congestion and collision under various conditions.

  8. A minimally invasive multiple marker approach allows highly efficient detection of meningioma tumors

    Directory of Open Access Journals (Sweden)

    Meese Eckart

    2006-12-01

    Full Text Available Abstract Background The development of effective frameworks that permit an accurate diagnosis of tumors, especially in their early stages, remains a grand challenge in the field of bioinformatics. Our approach uses statistical learning techniques applied to multiple antigen tumor antigen markers utilizing the immune system as a very sensitive marker of molecular pathological processes. For validation purposes we choose the intracranial meningioma tumors as model system since they occur very frequently, are mostly benign, and are genetically stable. Results A total of 183 blood samples from 93 meningioma patients (WHO stages I-III and 90 healthy controls were screened for seroreactivity with a set of 57 meningioma-associated antigens. We tested several established statistical learning methods on the resulting reactivity patterns using 10-fold cross validation. The best performance was achieved by Naïve Bayes Classifiers. With this classification method, our framework, called Minimally Invasive Multiple Marker (MIMM approach, yielded a specificity of 96.2%, a sensitivity of 84.5%, and an accuracy of 90.3%, the respective area under the ROC curve was 0.957. Detailed analysis revealed that prediction performs particularly well on low-grade (WHO I tumors, consistent with our goal of early stage tumor detection. For these tumors the best classification result with a specificity of 97.5%, a sensitivity of 91.3%, an accuracy of 95.6%, and an area under the ROC curve of 0.971 was achieved using a set of 12 antigen markers only. This antigen set was detected by a subset selection method based on Mutual Information. Remarkably, our study proves that the inclusion of non-specific antigens, detected not only in tumor but also in normal sera, increases the performance significantly, since non-specific antigens contribute additional diagnostic information. Conclusion Our approach offers the possibility to screen members of risk groups as a matter of routine

  9. A multi-disciplinary approach for the integrated assessment of multiple risks in delta areas.

    Science.gov (United States)

    Sperotto, Anna; Torresan, Silvia; Critto, Andrea; Marcomini, Antonio

    2016-04-01

    The assessment of climate change related risks is notoriously difficult due to the complex and uncertain combinations of hazardous events that might happen, the multiplicity of physical processes involved, the continuous changes and interactions of environmental and socio-economic systems. One important challenge lies in predicting and modelling cascades of natural and man -made hazard events which can be triggered by climate change, encompassing different spatial and temporal scales. Another regard the potentially difficult integration of environmental, social and economic disciplines in the multi-risk concept. Finally, the effective interaction between scientists and stakeholders is essential to ensure that multi-risk knowledge is translated into efficient adaptation and management strategies. The assessment is even more complex at the scale of deltaic systems which are particularly vulnerable to global environmental changes, due to the fragile equilibrium between the presence of valuable natural ecosystems and relevant economic activities. Improving our capacity to assess the combined effects of multiple hazards (e.g. sea-level rise, storm surges, reduction in sediment load, local subsidence, saltwater intrusion) is therefore essential to identify timely opportunities for adaptation. A holistic multi-risk approach is here proposed to integrate terminology, metrics and methodologies from different research fields (i.e. environmental, social and economic sciences) thus creating shared knowledge areas to advance multi risk assessment and management in delta regions. A first testing of the approach, including the application of Bayesian network analysis for the assessment of impacts of climate change on key natural systems (e.g. wetlands, protected areas, beaches) and socio-economic activities (e.g. agriculture, tourism), is applied in the Po river delta in Northern Italy. The approach is based on a bottom-up process involving local stakeholders early in different

  10. A multiple metrics approach to prioritizing strategies for measuring and managing reactive nitrogen in the San Joaquin Valley of California

    Science.gov (United States)

    Horowitz, Ariel I.; Moomaw, William R.; Liptzin, Daniel; Gramig, Benjamin M.; Reeling, Carson; Meyer, Johanna; Hurley, Kathleen

    2016-06-01

    Human alteration of the nitrogen cycle exceeds the safe planetary boundary for the use of reactive nitrogen (Nr). We complement global analysis by analyzing regional mass flows and the relative consequences of multiple chemical forms of Nr as they ‘cascade’ through multiple environmental media. The goals of this paper are (1) to identify the amounts of Nr that flow through a specific nitrogen rich region, (2) develop multiple metrics to characterize and compare multiple forms of Nr and the different damages that they cause, and (3) to use these metrics to assess the most societally acceptable and cost effective means for addressing the many dimensions of Nr damage. This paper uses a multiple metrics approach that in addition to mass flows considers economic damage, health and mitigation costs and qualitative damages to evaluate options for mitigating Nr flows in California’s San Joaquin Valley (SJV). Most analysis focuses attention on agricultural Nr because it is the largest flow in terms of mass. In contrast, the multiple metrics approach identifies mobile source Nr emissions as creating the most economic and health damage in the SJV. Emissions of Nr from mobile sources are smaller than those from crop agriculture and dairy in the SJV, but the benefits of abatement are greater because of reduced health impacts from air pollution, and abatement costs are lower. Our findings illustrate the benefit of a comprehensive multiple metrics approach to Nr management.

  11. A Hybrid One-Way ANOVA Approach for the Robust and Efficient Estimation of Differential Gene Expression with Multiple Patterns

    OpenAIRE

    Mohammad Manir Hossain Mollah; Rahman Jamal; Norfilza Mohd Mokhtar; Roslan Harun; Md. Nurul Haque Mollah

    2015-01-01

    Background Identifying genes that are differentially expressed (DE) between two or more conditions with multiple patterns of expression is one of the primary objectives of gene expression data analysis. Several statistical approaches, including one-way analysis of variance (ANOVA), are used to identify DE genes. However, most of these methods provide misleading results for two or more conditions with multiple patterns of expression in the presence of outlying genes. In this paper, an attempt ...

  12. A landscape lake flow pattern design approach based on automated CFD simulation and parallel multiple objective optimization.

    Science.gov (United States)

    Guo, Hao; Tian, Yimei; Shen, Hailiang; Wang, Yi; Kang, Mengxin

    A design approach for determining the optimal flow pattern in a landscape lake is proposed based on FLUENT simulation, multiple objective optimization, and parallel computing. This paper formulates the design into a multi-objective optimization problem, with lake circulation effects and operation cost as two objectives, and solves the optimization problem with non-dominated sorting genetic algorithm II. The lake flow pattern is modelled in FLUENT. The parallelization aims at multiple FLUENT instance runs, which is different from the FLUENT internal parallel solver. This approach: (1) proposes lake flow pattern metrics, i.e. weighted average water flow velocity, water volume percentage of low flow velocity, and variance of flow velocity, (2) defines user defined functions for boundary setting, objective and constraints calculation, and (3) parallels the execution of multiple FLUENT instances runs to significantly reduce the optimization wall-clock time. The proposed approach is demonstrated through a case study for Meijiang Lake in Tianjin, China.

  13. [Diet and multiple sclerosis].

    Science.gov (United States)

    Pozuelo-Moyano, Beatriz; Benito-León, Julián

    2014-05-16

    Introduccion. El tipo de dieta se ha relacionado con el proceso inflamatorio que forma parte de la esclerosis multiple (EM). En los ultimos años, distintas lineas de investigacion han generado una gran cantidad de conocimiento sobre la participacion de la dieta en la patogenesis de la EM. Objetivo. Elucidar de modo critico las evidencias que relacionan distintos tipos de dietas y alimentos con la EM. Desarrollo. Se incluye una actualizacion de los estudios publicados mas significativos que han analizado el papel de la dieta en la patogenesis y en el tratamiento de la EM. Para explorar la asociacion entre la dieta y el riesgo de EM se ha revisado la evidencia disponible hasta el momento, pasando por estudios observacionales hasta terminar con estudios de intervencion. Conclusiones. Se necesita mas investigacion sobre la nutricion como factor de riesgo, ya que podria tener relacion con la enfermedad, y el control de esta podria llevar a una disminucion significativa de la incidencia o progresion de la patologia.

  14. [Smoking and multiple sclerosis].

    Science.gov (United States)

    Arruti, Maialen; Castillo-Triviño, Tamara; Egüés, Nerea; Olascoaga, Javier

    2015-02-16

    Introduccion. La esclerosis multiple (EM) es una enfermedad autoinmune de etiologia compleja, hoy por hoy desconocida, en la que factores geneticos y ambientales determinan la susceptibilidad. En los ultimos años, el efecto del tabaco ha sido uno de los factores ambientales que ha emergido en la EM, y se ha asociado tanto a un aumento de la susceptibilidad como a un aumento de la progresion. Objetivo. Revisar la evidencia actual sobre el papel del tabaco en la EM. Desarrollo. Se incluye una actualizacion de los estudios publicados que han analizado distintos aspectos del tabaco en la EM: vias patogenicas implicadas, asociacion del tabaco y riesgo de EM, interaccion con otros factores de riesgo y efecto del tabaco en el curso de la enfermedad. Conclusiones. Los estudios observacionales demuestran que el tabaquismo incrementa de forma significativa el riesgo de EM (odds ratio ~ 1,5) y es un factor de riesgo independiente. Sin embargo, la EM es una enfermedad compleja y el aumento de riesgo por el tabaco puede diferir en funcion de la interaccion con otros factores geneticos y ambientales. El papel del tabaco como factor de progresion es mas controvertido, con resultados contradictorios y estudios de gran variabilidad, lo que dificulta establecer una conclusion firme. Los mecanismos por los que el tabaquismo modifica el riesgo y posiblemente la progresion de la enfermedad no son aun conocidos.

  15. Risk Governance of Multiple Natural Hazards: Centralized versus Decentralized Approach in Europe

    Science.gov (United States)

    Komendantova, Nadejda; Scolobig, Anna; Vinchon, Charlotte

    2014-05-01

    The multi-risk approach is a relatively new field and its definition includes the need to consider multiple hazards and vulnerabilities in their interdependency (Selva, 2013) and the current multi-hazards disasters, such as the 2011 Tohoku earthquake, tsunami and nuclear catastrophe, showed the need for a multi-risk approach in hazard mitigation and management. Our knowledge about multi-risk assessment, including studies from different scientific disciplines and developed assessment tools, is constantly growing (White et al., 2001). However, the link between scientific knowledge, its implementation and the results in terms of improved governance and decision-making have gained significantly less attention (IRGC, 2005; Kappes et al., 2012), even though the interest to risk governance, in general, has increased significantly during the last years (Verweiy and Thompson, 2006). Therefore, the key research question is how risk assessment is implemented and what is the potential for the implementation of a multi-risk approach in different governance systems across Europe. More precisely, how do the characteristics of risk governance, such as the degree of centralization versus decentralization, influence the implementation of a multi-risk approach. The methodology of this research includes comparative case study analysis of top-down and bottom-up interactions in governance in the city of Naples, (Italy), where the institutional landscape is marked by significant autonomy of Italian regions in decision-making processes for assessing the majority of natural risks, excluding volcanic, and in Guadeloupe, French West Indies, an overseas department of France, where the decision-making process is marked by greater centralization in decision making associated with a well established state governance within regions, delegated to the prefect and decentralised services of central ministries. The research design included documentary analysis and extensive empirical work involving

  16. Individual exposure to air pollution and lung function in Korea: spatial analysis using multiple exposure approaches.

    Science.gov (United States)

    Son, Ji-Young; Bell, Michelle L; Lee, Jong-Tae

    2010-11-01

    Interpolation methods can estimate individual-level exposures to air pollution from ambient monitors; however, few studies have evaluated how different approaches may affect health risk estimates. We applied multiple methods of estimating exposure for several air pollutants. We investigated how different methods of estimating exposure may influence health effect estimates in a case study of lung function data, forced expiratory volume in 1s (FEV1), and forced vital capacity (FVC), for 2102 cohort subjects in Ulsan, Korea, for 2003-2007. Measurements from 13 monitors for particulate matter inverse distance weighting, and kriging. We assessed associations between pollutants and lung function in linear regression models, controlling for age, sex, and body mass index. Cross-validation indicated that kriging provided the most accurate estimated exposures. FVC was associated with all air pollutants under all methods of estimating exposure. Only ozone was associated with FEV1. An 11 ppb increase in lag-0-2 8-h maximum ozone was associated with a 6.1% (95% confidence interval 5.0, 7.3%) decrease in FVC and a 0.50% (95% confidence interval 0.03, 0.96%) decrease in FEV1, based on kriged exposures. Central health effect estimates were generally higher using exposures based on averaging across all monitors or kriging. Results based on the nearest monitor approach had the lowest variance. Findings suggest that spatial interpolation methods may provide better estimates than monitoring values alone by reflecting the spatial variability of individual-level exposures and generating estimates for locations without monitors.

  17. La difícil decisión de ventilación mecánica en esclerosis lateral amiotrófica: A propósito de dos casos.

    OpenAIRE

    Rey de Castro Mujica, Jorge; PORTOCARRERO URDAY, Alexandra; VALDEZ FERNANDEZ-BACA, Luis Manuel

    2012-01-01

    Esclerosis Lateral Amiotrófica (ELA) es una enfermedad progresiva y debilitante, invariablemente fatal que afecta a las neuronas motoras, en la que las funciones cognitivas del paciente permanecen intactas y habitualmente en las fases avanzadas se presenta insuficiencia respiratoria ventilatoria requiriendo alguna modalidad de soporte ventilatorio. Dos casos con diagnóstico de ELA forma bulbar se beneficiaron de esta intervención terapéutica en nuestra ciudad.

  18. A sequential approach to calibrate ecosystem models with multiple time series data

    Science.gov (United States)

    Oliveros-Ramos, Ricardo; Verley, Philippe; Echevin, Vincent; Shin, Yunne-Jai

    2017-02-01

    When models are aimed to support decision-making, their credibility is essential to consider. Model fitting to observed data is one major criterion to assess such credibility. However, due to the complexity of ecosystem models making their calibration more challenging, the scientific community has given more attention to the exploration of model behavior than to a rigorous comparison to observations. This work highlights some issues related to the comparison of complex ecosystem models to data and proposes a methodology for a sequential multi-phases calibration (or parameter estimation) of ecosystem models. We first propose two criteria to classify the parameters of a model: the model dependency and the time variability of the parameters. Then, these criteria and the availability of approximate initial estimates are used as decision rules to determine which parameters need to be estimated, and their precedence order in the sequential calibration process. The end-to-end (E2E) ecosystem model ROMS-PISCES-OSMOSE applied to the Northern Humboldt Current Ecosystem is used as an illustrative case study. The model is calibrated using an evolutionary algorithm and a likelihood approach to fit time series data of landings, abundance indices and catch at length distributions from 1992 to 2008. Testing different calibration schemes regarding the number of phases, the precedence of the parameters' estimation, and the consideration of time varying parameters, the results show that the multiple-phase calibration conducted under our criteria allowed to improve the model fit.

  19. Drug repurposing: a systematic approach to evaluate candidate oral neuroprotective interventions for secondary progressive multiple sclerosis.

    Directory of Open Access Journals (Sweden)

    Hanna M Vesterinen

    Full Text Available To develop and implement an evidence based framework to select, from drugs already licenced, candidate oral neuroprotective drugs to be tested in secondary progressive multiple sclerosis.Systematic review of clinical studies of oral putative neuroprotective therapies in MS and four other neurodegenerative diseases with shared pathological features, followed by systematic review and meta-analyses of the in vivo experimental data for those interventions. We presented summary data to an international multi-disciplinary committee, which assessed each drug in turn using pre-specified criteria including consideration of mechanism of action.We identified a short list of fifty-two candidate interventions. After review of all clinical and pre-clinical evidence we identified ibudilast, riluzole, amiloride, pirfenidone, fluoxetine, oxcarbazepine, and the polyunsaturated fatty-acid class (Linoleic Acid, Lipoic acid; Omega-3 fatty acid, Max EPA oil as lead candidates for clinical evaluation.We demonstrate a standardised and systematic approach to candidate identification for drug rescue and repurposing trials that can be applied widely to neurodegenerative disorders.

  20. A Multiple-Model Approach for Synchronous Generator Nonlinear System Identification

    Science.gov (United States)

    Ahmadi, Seyed Salman; Karrari, Mehdi

    2012-07-01

    In this paper, a multiple model approach is proposed for the identification of synchronous generators. In the literature, the same structure often is used for all local models. Therefore, to obtain a precise model for the operating condition of the synchronous generator with severely nonlinear behavior, many local models are required. The proposed method determines the complexity of local models based on complexity of behavior of the synchronous generator at different operating conditions. There are two choices for increasing model precision at each iteration of the proposed method: (i) increasing the number of local models in one region, or (ii) increasing local model complexity in the same region. The proposed method has been tested on experimental data collected on a 3 kVA micro-machine. In the study, the field voltage is considered as the input and the active output power and the terminal voltage are considered as the outputs of the synchronous generator. The proposed method provides a more precise model with fewer parameters compared to some well known methods such as LOLIMOT and global polynomial models.

  1. An Approach to Automatic Motion Synthesis Harmonized with Music for Multiple Objects

    Science.gov (United States)

    Wang, Qi; Nakatani, Mie; Nishida, Shogo

    This paper proposed a research approach to automatic choreography synthesis based on SMF(Standard Midi File) for multiple animated figures. Based on the K.Hevner’s theory, 8 types of emotion in each beat can be extracted from music structure elements, such as tempo, key, rythm, melody, harmony, pitch, which can be computed from SMF. The time of one beat is limited to transmit the emotion to human. By the analysis of emotion, a music can be integrated to several time intervals, every which includes several continuous beats. The top value of synthetic emotion vector represents the emotion type of the interval. Based on the experiment result of C.Matsumoto, 14 motion factors can be mapped from the emotion of interval. According to the 14 motion factors, the macro-motions at the terminals of every interval, and the micromotions between every interval can be generated by mapping rules. We made a prototype system and did a subjective evaluation experiment. The result is fairly good at the congruity between generated motions and given emotion music. A successful research to solve these issues should lead to aid the designation of 3DCG animation.

  2. A Novel Multiple Attribute Satisfaction Evaluation Approach with Hesitant Intuitionistic Linguistic Fuzzy Information

    Directory of Open Access Journals (Sweden)

    Shanghong Yang

    2014-01-01

    Full Text Available This paper investigates the multiple attribute decision making (MADM problems in which the attribute values take the form of hesitant intuitionistic linguistic fuzzy element (HILFE. Firstly, motivated by the idea of intuitionistic linguistic variables (ILVs and hesitant fuzzy elements (HFEs, the concept, operational laws, and comparison laws of HILFE are defined. Then, some aggregation operators are developed for aggregating the hesitant intuitionistic linguistic fuzzy information, such as hesitant intuitionistic linguistic fuzzy weighted aggregation operators, hesitant intuitionistic linguistic fuzzy ordered weighted aggregation operators, and generalized hesitant intuitionistic linguistic fuzzy weighted aggregation operators. Moreover, some desirable properties of these operators and the relationships between them are discussed. Based on the hesitant intuitionistic linguistic fuzzy weighted average (HILFWA operator and the hesitant intuitionistic linguistic fuzzy weighted geometric (HILFWG operator, an approach for evaluating satisfaction degree is proposed under hesitant intuitionistic linguistic fuzzy environment. Finally, a practical example of satisfaction evaluation for milk products is given to illustrate the application of the proposed method and to demonstrate its practicality and effectiveness.

  3. Predicting multiple ecotoxicological profiles in agrochemical fungicides: a multi-species chemoinformatic approach.

    Science.gov (United States)

    Speck-Planche, Alejandro; Kleandrova, Valeria V; Luan, Feng; Cordeiro, M Natália D S

    2012-06-01

    Agriculture is needed to deal with crop losses caused by biotic stresses like pests. The use of pesticides has played a vital role, contributing to improve crop production and harvest productivity, providing a better crop quality and supply, and consequently contributing with the improvement of the human health. An important group of these pesticides is fungicides. However, the use of these agrochemical fungicides is an important source of contamination, damaging the ecosystems. Several studies have been realized for the assessment of the toxicity in agrochemical fungicides, but the principal limitation is the use of structurally related compounds against usually one indicator species. In order to overcome this problem, we explore the quantitative structure-toxicity relationships (QSTR) in agrochemical fungicides. Here, we developed the first multi-species (ms) chemoinformatic approach for the prediction multiple ecotoxicological profiles of fungicides against 20 indicators species and their classifications in toxic or nontoxic. The ms-QSTR discriminant model was based on substructural descriptors and a heterogeneous database of compounds. The percentages of correct classification were higher than 90% for both, training and prediction series. Also, substructural alerts responsible for the toxicity/no toxicity in fungicides respect all ecotoxicological profiles, were extracted and analyzed.

  4. Formation tracker design of multiple mobile robots with wheel perturbations: adaptive output-feedback approach

    Science.gov (United States)

    Yoo, Sung Jin

    2016-11-01

    This paper presents a theoretical design approach for output-feedback formation tracking of multiple mobile robots under wheel perturbations. It is assumed that these perturbations are unknown and the linear and angular velocities of the robots are unmeasurable. First, adaptive state observers for estimating unmeasurable velocities of the robots are developed under the robots' kinematics and dynamics including wheel perturbation effects. Then, we derive a virtual-structure-based formation tracker scheme according to the observer dynamic surface design procedure. The main difficulty of the output-feedback control design is to manage the coupling problems between unmeasurable velocities and unknown wheel perturbation effects. These problems are avoided by using the adaptive technique and the function approximation property based on fuzzy logic systems. From the Lyapunov stability analysis, it is shown that point tracking errors of each robot and synchronisation errors for the desired formation converge to an adjustable neighbourhood of the origin, while all signals in the controlled closed-loop system are semiglobally uniformly ultimately bounded.

  5. Machine learning approach identifies new pathways associated with demyelination in a viral model of multiple sclerosis

    Science.gov (United States)

    Ulrich, Reiner; Kalkuhl, Arno; Deschl, Ulrich; Baumgärtner, Wolfgang

    2010-01-01

    Abstract Theiler’s murine encephalomyelitis is an experimentally virus-induced inflammatory demyelinating disease of the spinal cord, displaying clinical and pathological similarities to chronic progressive multiple sclerosis. The aim of this study was to identify pathways associated with chronic demyelination using an assumption-free combined microarray and immunohistology approach. Movement control as determined by rotarod assay significantly worsened in Theiler’s murine encephalomyelitis -virus-infected SJL/J mice from 42 to 196 days after infection (dpi). In the spinal cords, inflammatory changes were detected 14 to 196 dpi, and demyelination progressively increased from 42 to 196 dpi. Microarray analysis revealed 1001 differentially expressed genes over the study period. The dominating changes as revealed by k-means and functional annotation clustering included up-regulations related to intrathecal antibody production and antigen processing and presentation via major histocompatibility class II molecules. A random forest machine learning algorithm revealed that down-regulated lipid and cholesterol biosynthesis, differentially expressed neurite morphogenesis and up-regulated toll-like receptor-4-induced pathways were intimately associated with demyelination as measured by immunohistology. Conclusively, although transcriptional changes were dominated by the adaptive immune response, the main pathways associated with demyelination included up-regulation of toll-like receptor 4 and down-regulation of cholesterol biosynthesis. Cholesterol biosynthesis is a rate limiting step of myelination and its down-regulation is suggested to be involved in chronic demyelination by an inhibition of remyelination. PMID:19183246

  6. Examination of the role of magnetic resonance imaging in multiple sclerosis: A problem-orientated approach

    Directory of Open Access Journals (Sweden)

    McFarland Henry

    2009-01-01

    Full Text Available Magnetic Resonance Imaging (MRI has brought in several benefits to the study of Multiple Sclerosis (MS. It provides accurate measurement of disease activity, facilitates precise diagnosis, and aid in the assessment of newer therapies. The imaging guidelines for MS are broadly divided in to approaches for imaging patients with suspected MS or clinically isolated syndromes (CIS or for monitoring patients with established MS. In this review, the technical aspects of MR imaging for MS are briefly discussed. The imaging process need to capture the twin aspects of acute MS viz. the autoimmune acute inflammatory process and the neurodegenerative process. Gadolinium enhanced MRI can identify acute inflammatory lesions precisely. The commonly applied MRI marker of disease progression is brain atrophy. Whole brain magnetization Transfer Ratio (MTR and Magnetic Resonance Spectroscopy (MRS are two other techniques use to monitor disease progression. A variety of imaging techniques such as Double Inversion Recovery (DIR, Spoiled Gradient Recalled (SPGR acquisition, and Fluid Attenuated Inversion Recovery (FLAIR have been utilized to study the cortical changes in MS. MRI is now extensively used in the Phase I, II and III clinical trials of new therapies. As the technical aspects of MRI advance rapidly, and higher field strengths become available, it is hoped that the impact of MRI on our understanding of MS will be even more profound in the next decade.

  7. A Novel Kalman Filter with State Constraint Approach for the Integration of Multiple Pedestrian Navigation Systems

    Directory of Open Access Journals (Sweden)

    Haiyu Lan

    2015-07-01

    Full Text Available Numerous solutions/methods to solve the existing problems of pedestrian navigation/localization have been proposed in the last decade by both industrial and academic researchers. However, to date there are still major challenges for a single pedestrian navigation system (PNS to operate continuously, robustly, and seamlessly in all indoor and outdoor environments. In this paper, a novel method for pedestrian navigation approach to fuse the information from two separate PNSs is proposed. When both systems are used at the same time by a specific user, a nonlinear inequality constraint between the two systems’ navigation estimates always exists. Through exploring this constraint information, a novel filtering technique named Kalman filter with state constraint is used to diminish the positioning errors of both systems. The proposed method was tested by fusing the navigation information from two different PNSs, one is the foot-mounted inertial navigation system (INS mechanization-based system, the other PNS is a navigation device that is mounted on the user’s upper body, and adopting the pedestrian dead reckoning (PDR mechanization for navigation update. Monte Carlo simulations and real field experiments show that the proposed method for the integration of multiple PNSs could improve each PNS’ navigation performance.

  8. The impact of a multiple intelligences teaching approach drug education programme on drug refusal skills of Nigerian pupils.

    Science.gov (United States)

    Nwagu, Evelyn N; Ezedum, Chuks E; Nwagu, Eric K N

    2015-09-01

    The rising incidence of drug abuse among youths in Nigeria is a source of concern for health educators. This study was carried out on primary six pupils to determine the effect of a Multiple Intelligences Teaching Approach Drug Education Programme (MITA-DEP) on pupils' acquisition of drug refusal skills. A programme of drug education based on the Multiple Intelligences Teaching Approach (MITA) was developed. An experimental group was taught using this programme while a control group was taught using the same programme but developed based on the Traditional Teaching Approach. Pupils taught with the MITA acquired more drug refusal skills than those taught with the Traditional Teaching Approach. Urban pupils taught with the MITA acquired more skills than rural pupils. There was no statistically significant difference in the mean refusal skills of male and female pupils taught with the MITA.

  9. Correlations between multiplicities and average transverse momentum in the percolating colour strings approach

    CERN Document Server

    Braun, M A; Pajares, C; Vechernin, V V

    2004-01-01

    Long range correlations multiplicity-multiplicity, $p_T^2$-multiplicity and $p^2 - p^2_T$ are studied in the percolating colour string picture under different assumptions of the dynamics of string interaction. It is found that the strength of these correlations is rather insensitive to these assumptions nor to the geometry of formed fused string clusters. Both multiplicity-multiplicity and $p_T^2$-multiplicity correlations are found to scale and depend only on the string density. The $p_T^2$-multiplicity correlations, which are absent in the independent string picture, are found to be of the order of 10% for central heavy ion collisions and can serve as a clear signature of string fusion. In contrast the $p^2_T - p^2_T$ correlations turned out to be inversely proportional to the number of strings and so very small for relaistic collisions.

  10. Speech and Language Therapists' Approaches to Communication Intervention with Children and Adults with Profound and Multiple Learning Disability

    Science.gov (United States)

    Goldbart, Juliet; Chadwick, Darren; Buell, Susan

    2014-01-01

    Background: People with profound intellectual and multiple disabilities (PMLD) have communication impairments as one defining characteristic. Aims: To explore speech and language therapists' (SLTs) decision making in communication interventions for people with PMLD, in terms of the intervention approaches used, the factors informing the decisions…

  11. PMCHAP: a new approach for haplotype inference using nuclear families with only one parent and multiple offspring.

    Science.gov (United States)

    Ding, X D; Zhang, Q; Simianer, H

    2008-10-01

    A new approach is suggested to perform joint haplotype reconstruction and haplotype frequency estimation in families consisting of multiple full sibs where only one parent is genotyped. It can also deal with the mixed data structures with 0 and 1 parent genotyped. The approach is based on the maximum likelihood principle using the expectation-maximization algorithm and thus combines pedigree information within families and linkage disequilibrium information between families with assumption of no recombination. In a simulation study of single nucleotide polymorphisms, the new algorithm termed PMCHAP (parent multiple children haplotyping) is shown to provide significantly better results than an approximation used so far, especially providing better estimates with increasing family sizes. It will be especially helpful for research in multiparous species like pigs, dogs, fish, and many lab animals where it is easy to collect families with multiple siblings.

  12. Strongly and weakly directed approaches to teaching multiple representation use in physics

    OpenAIRE

    David Rosengrant; Kohl, Patrick B.; Finkelstein, Noah D.

    2007-01-01

    Good use of multiple representations is considered key to learning physics, and so there is considerable motivation both to learn how students use multiple representations when solving problems and to learn how best to teach problem solving using multiple representations. In this study of two large-lecture algebra-based physics courses at the University of Colorado (CU) and Rutgers, the State University of New Jersey, we address both issues. Students in each of the two courses solved five com...

  13. Carbon balance assessment of a natural steppe of southern Siberia by multiple constraint approach

    Directory of Open Access Journals (Sweden)

    L. Belelli Marchesini

    2007-01-01

    Full Text Available Steppe ecosystems represent an interesting case in which the assessment of carbon balance may be performed through a cross validation of the eddy covariance measurements against ecological inventory estimates of carbon exchanges (Ehman, 2002; Curtis, 2002.

    Indeed, the widespread presence of ideal conditions for the applicability of the eddy covariance technique, as vast and homogeneous grass vegetation cover over flat terrains (Baldocchi, 2003, make steppes a suitable ground to ensure a constrain to flux estimates with independent methodological approaches.

    We report about the analysis of the carbon cycle of a true steppe ecosystem in southern Siberia during the growing season of 2004 in the framework of the TCOS-Siberia project activities performed by continuous monitoring of CO2 fluxes at ecosystem scale by the eddy covariance method, fortnightly samplings of phytomass, and ingrowth cores extractions for NPP assessment, and weekly measurements of heterotrophic component of soil CO2 effluxes obtained by an experiment of root exclusion.

    The carbon balance of the monitored natural steppe was, according to micrometeorological measurements, a sink of carbon of 151.7± 30.1 gC m−2, cumulated during the growing season from May to September. This result was in agreement with the independent estimate through ecological inventory which yielded a sink of 150.1 gC m−2 although this method was characterized by a large uncertainty (±130% considering the 95% confidence interval of the estimate. Uncertainties in belowground process estimates account for a large part of the error. Thus, in particular efforts to better quantify the dynamics of root biomass (growth and turnover have to be undertaken in order to reduce the uncertainties in the assessment of NPP. This assessment should be preferably based on the application of multiple methods, each one characterized by its own merits and

  14. SiteBinder: an improved approach for comparing multiple protein structural motifs.

    Science.gov (United States)

    Sehnal, David; Vařeková, Radka Svobodová; Huber, Heinrich J; Geidl, Stanislav; Ionescu, Crina-Maria; Wimmerová, Michaela; Koča, Jaroslav

    2012-02-27

    There is a paramount need to develop new techniques and tools that will extract as much information as possible from the ever growing repository of protein 3D structures. We report here on the development of a software tool for the multiple superimposition of large sets of protein structural motifs. Our superimposition methodology performs a systematic search for the atom pairing that provides the best fit. During this search, the RMSD values for all chemically relevant pairings are calculated by quaternion algebra. The number of evaluated pairings is markedly decreased by using PDB annotations for atoms. This approach guarantees that the best fit will be found and can be applied even when sequence similarity is low or does not exist at all. We have implemented this methodology in the Web application SiteBinder, which is able to process up to thousands of protein structural motifs in a very short time, and which provides an intuitive and user-friendly interface. Our benchmarking analysis has shown the robustness, efficiency, and versatility of our methodology and its implementation by the successful superimposition of 1000 experimentally determined structures for each of 32 eukaryotic linear motifs. We also demonstrate the applicability of SiteBinder using three case studies. We first compared the structures of 61 PA-IIL sugar binding sites containing nine different sugars, and we found that the sugar binding sites of PA-IIL and its mutants have a conserved structure despite their binding different sugars. We then superimposed over 300 zinc finger central motifs and revealed that the molecular structure in the vicinity of the Zn atom is highly conserved. Finally, we superimposed 12 BH3 domains from pro-apoptotic proteins. Our findings come to support the hypothesis that there is a structural basis for the functional segregation of BH3-only proteins into activators and enablers.

  15. Harmonisation of variables names prior to conducting statistical analyses with multiple datasets: an automated approach

    Directory of Open Access Journals (Sweden)

    Bosch-Capblanch Xavier

    2011-05-01

    Full Text Available Abstract Background Data requirements by governments, donors and the international community to measure health and development achievements have increased in the last decade. Datasets produced in surveys conducted in several countries and years are often combined to analyse time trends and geographical patterns of demographic and health related indicators. However, since not all datasets have the same structure, variables definitions and codes, they have to be harmonised prior to submitting them to the statistical analyses. Manually searching, renaming and recoding variables are extremely tedious and prone to errors tasks, overall when the number of datasets and variables are large. This article presents an automated approach to harmonise variables names across several datasets, which optimises the search of variables, minimises manual inputs and reduces the risk of error. Results Three consecutive algorithms are applied iteratively to search for each variable of interest for the analyses in all datasets. The first search (A captures particular cases that could not be solved in an automated way in the search iterations; the second search (B is run if search A produced no hits and identifies variables the labels of which contain certain key terms defined by the user. If this search produces no hits, a third one (C is run to retrieve variables which have been identified in other surveys, as an illustration. For each variable of interest, the outputs of these engines can be (O1 a single best matching variable is found, (O2 more than one matching variable is found or (O3 not matching variables are found. Output O2 is solved by user judgement. Examples using four variables are presented showing that the searches have a 100% sensitivity and specificity after a second iteration. Conclusion Efficient and tested automated algorithms should be used to support the harmonisation process needed to analyse multiple datasets. This is especially relevant when

  16. Predicting relapsing-remitting dynamics in multiple sclerosis using discrete distribution models: a population approach.

    Directory of Open Access Journals (Sweden)

    Nieves Velez de Mendizabal

    Full Text Available Relapsing-remitting dynamics are a hallmark of autoimmune diseases such as Multiple Sclerosis (MS. A clinical relapse in MS reflects an acute focal inflammatory event in the central nervous system that affects signal conduction by damaging myelinated axons. Those events are evident in T1-weighted post-contrast magnetic resonance imaging (MRI as contrast enhancing lesions (CEL. CEL dynamics are considered unpredictable and are characterized by high intra- and inter-patient variability. Here, a population approach (nonlinear mixed-effects models was applied to analyse of CEL progression, aiming to propose a model that adequately captures CEL dynamics.We explored several discrete distribution models to CEL counts observed in nine MS patients undergoing a monthly MRI for 48 months. All patients were enrolled in the study free of immunosuppressive drugs, except for intravenous methylprednisolone or oral prednisone taper for a clinical relapse. Analyses were performed with the nonlinear mixed-effect modelling software NONMEM 7.2. Although several models were able to adequately characterize the observed CEL dynamics, the negative binomial distribution model had the best predictive ability. Significant improvements in fitting were observed when the CEL counts from previous months were incorporated to predict the current month's CEL count. The predictive capacity of the model was validated using a second cohort of fourteen patients who underwent monthly MRIs during 6-months. This analysis also identified and quantified the effect of steroids for the relapse treatment.The model was able to characterize the observed relapsing-remitting CEL dynamic and to quantify the inter-patient variability. Moreover, the nature of the effect of steroid treatment suggested that this therapy helps resolve older CELs yet does not affect newly appearing active lesions in that month. This model could be used for design of future longitudinal studies and clinical trials, as

  17. (Re-) Framing Authenticity: Considering Multiple Social Identities Using Autoethnographic and Intersectional Approaches

    Science.gov (United States)

    Jones, Susan R.; Kim, Yoolee Choe; Skendall, Kristan Cilente

    2012-01-01

    The purpose of this autoethnographic study was to explore the lived experience of identity construction and negotiation of multiple identities using an intersectional framework. Results present examples of the troublesome nature of authenticity as multiple identities were negotiated and managed based upon context and the influence of power and…

  18. A Multiple-plane Approach to Measure the Structural Properties of Functionally Active Regions in the Human Cortex

    Science.gov (United States)

    Wang, Xin; Garfinkel, Sarah N.; King, Anthony P.; Angstadt, Mike; Dennis, Michael J.; Xie, Hong; Welsh, Robert C.; Tamburrino, Marijo B.; Liberzon, Israel

    2009-01-01

    Advanced magnetic resonance imaging (MRI) techniques provide the means of studying both the structural and the functional properties of various brain regions, allowing us to address the relationship between the structural changes in human brain regions and the activity of these regions. However, analytical approaches combining functional (fMRI) and structural (sMRI) information are still far from optimal. In order to improve the accuracy of measurement of structural properties in active regions, the current study tested a new analytical approach that repeated a surface-based analysis at multiple planes crossing different depths of cortex. Twelve subjects underwent a fear conditioning study. During these tasks, fMRI and sMRI scans were acquired. The fMRI images were carefully registered to the sMRI images with an additional correction for cortical borders. The fMRI images were then analyzed with the new multiple-plane surface-based approach as compared to the volume-based approach, and the cortical thickness and volume of an active region were measured. The results suggested (1) using an additional correction for cortical borders and an intermediate template image produced an acceptable registration of fMRI and sMRI images; (2) surface-based analysis at multiple depths of cortex revealed more activity than the same analysis at any single depth; (3) projection of active surface vertices in a ribbon fashion improved active volume estimates; and (4) correction with gray matter segmentation removed non-cortical regions from the volumetric measurement of active regions. In conclusion, the new multiple-plane surface-based analysis approaches produce improved measurement of cortical thickness and volume of active brain regions. These results support the use of novel approaches for combined analysis of functional and structural neuroimaging. PMID:19922802

  19. Tailor-made rehabilitation approach using multiple types of hybrid assistive limb robots for acute stroke patients: A pilot study.

    Science.gov (United States)

    Fukuda, Hiroyuki; Morishita, Takashi; Ogata, Toshiyasu; Saita, Kazuya; Hyakutake, Koichi; Watanabe, Junko; Shiota, Etsuji; Inoue, Tooru

    2016-01-01

    This article investigated the feasibility of a tailor-made neurorehabilitation approach using multiple types of hybrid assistive limb (HAL) robots for acute stroke patients. We investigated the clinical outcomes of patients who underwent rehabilitation using the HAL robots. The Brunnstrom stage, Barthel index (BI), and functional independence measure (FIM) were evaluated at baseline and when patients were transferred to a rehabilitation facility. Scores were compared between the multiple-robot rehabilitation and single-robot rehabilitation groups. Nine hemiplegic acute stroke patients (five men and four women; mean age 59.4 ± 12.5 years; four hemorrhagic stroke and five ischemic stroke) underwent rehabilitation using multiple types of HAL robots for 19.4 ± 12.5 days, and 14 patients (six men and eight women; mean age 63.2 ± 13.9 years; nine hemorrhagic stroke and five ischemic stroke) underwent rehabilitation using a single type of HAL robot for 14.9 ± 8.9 days. The multiple-robot rehabilitation group showed significantly better outcomes in the Brunnstrom stage of the upper extremity, BI, and FIM scores. To the best of the authors' knowledge, this is the first pilot study demonstrating the feasibility of rehabilitation using multiple exoskeleton robots. The tailor-made rehabilitation approach may be useful for the treatment of acute stroke.

  20. Multiple classifier systems in texton-based approach for the classification of CT images of Lung

    DEFF Research Database (Denmark)

    Gangeh, Mehrdad J.; Sørensen, Lauge; Shaker, Saher B.

    2010-01-01

    In this paper, we propose using texton signatures based on raw pixel representation along with a parallel multiple classifier system for the classification of emphysema in computed tomography images of the lung. The multiple classifier system is composed of support vector machines on the texton.......e., texton size and k value in k-means. Our results show that while aggregation of single decisions by SVMs over various k values using multiple classifier systems helps to improve the results compared to single SVMs, combining over different texton sizes is not beneficial. The performance of the proposed...

  1. Charged particle multiplicity and transverse energy distribution using Weibull-Glauber approach in heavy-ion collisions

    CERN Document Server

    Behera, Nirbhay K; Naik, Bharati; Nandi, Basanta K; Pani, Tanmay

    2016-01-01

    The charged particle multiplicity distribution and the transverse energy distribution measured in heavy-ion collisions at top RHIC and LHC energies are described using the two-component model approach based on convolution of Monte Carlo Glauber model with the Weibull model for particle production. The model successfully describes the multiplicity and transverse energy distribution of minimum bias collision data for a wide range of energies. We also propose that Weibull-Glauber model can be used to determine the centrality classes in heavy-ion collision as an alternative to the conventional Negative Binomial distribution for particle production.

  2. Field data and numerical modeling: A multiple lines of evidence approach for assessing vapor intrusion exposure risks.

    Science.gov (United States)

    Pennell, Kelly G; Scammell, Madeleine K; McClean, Michael D; Suuberg, Eric M; Moradi, Ali; Roghani, Mohammadyousef; Ames, Jennifer; Friguglietti, Leigh; Indeglia, Paul A; Shen, Rui; Yao, Yijun; Heiger-Bernays, Wendy J

    2016-06-15

    USEPA recommends a multiple lines of evidence approach to make informed decisions at vapor intrusion sites because the vapor intrusion pathway is notoriously difficult to characterize. Our study uses this approach by incorporating groundwater, soil gas, indoor air field measurements and numerical models to evaluate vapor intrusion exposure risks in a Metro-Boston neighborhood known to exhibit lower than anticipated indoor air concentrations based on groundwater concentrations. We collected and evaluated five rounds of field sampling data over the period of one year. Field data results show a steep gradient in soil gas concentrations near the groundwater surface; however as the depth decreases, soil gas concentration gradients also decrease. Together, the field data and the numerical model results suggest that a subsurface feature is limiting vapor transport into indoor air spaces at the study site and that groundwater concentrations are not appropriate indicators of vapor intrusion exposure risks in this neighborhood. This research also reveals the importance of including relevant physical models when evaluating vapor intrusion exposure risks using the multiple lines of evidence approach. Overall, the findings provide insight about how the multiple lines of evidence approach can be used to inform decisions by using field data collected using regulatory-relevant sampling techniques, and a well-established 3-D vapor intrusion model.

  3. A Combined PMHT and IMM Approach to Multiple-Point Target Tracking in Infrared Image Sequence

    Directory of Open Access Journals (Sweden)

    Mukesh A. Zaveri

    2007-09-01

    Full Text Available Data association and model selection are important factors for tracking multiple targets in a dense clutter environment. In this paper, we provide an effective solution to the tracking of multiple single-pixel maneuvering targets in a sequence of infrared images by developing an algorithm that combines a sequential probabilistic multiple hypothesis tracking (PMHT and interacting multiple model (IMM. We explicitly model maneuver as a change in the target's motion model and demonstrate its effectiveness in our tracking application discussed in this paper. We show that inclusion of IMM enables tracking of any arbitrary trajectory in a sequence of infrared images without any a priori special information about the target dynamics. IMM allows us to incorporate different dynamic models for the targets and PMHT helps to avoid the uncertainty about the observation origin. It operates in an iterative mode using expectation-maximization (EM algorithm. The proposed algorithm uses observation association as missing data.

  4. A Combined PMHT and IMM Approach to Multiple-Point Target Tracking in Infrared Image Sequence

    Directory of Open Access Journals (Sweden)

    Merchant SN

    2007-01-01

    Full Text Available Data association and model selection are important factors for tracking multiple targets in a dense clutter environment. In this paper, we provide an effective solution to the tracking of multiple single-pixel maneuvering targets in a sequence of infrared images by developing an algorithm that combines a sequential probabilistic multiple hypothesis tracking (PMHT and interacting multiple model (IMM. We explicitly model maneuver as a change in the target's motion model and demonstrate its effectiveness in our tracking application discussed in this paper. We show that inclusion of IMM enables tracking of any arbitrary trajectory in a sequence of infrared images without any a priori special information about the target dynamics. IMM allows us to incorporate different dynamic models for the targets and PMHT helps to avoid the uncertainty about the observation origin. It operates in an iterative mode using expectation-maximization (EM algorithm. The proposed algorithm uses observation association as missing data.

  5. A geospatial modelling approach to predict seagrass habitat recovery under multiple stressor regimes

    Science.gov (United States)

    Restoration of estuarine seagrass habitats requires a clear understanding of the modes of action of multiple interacting stressors including nutrients, climate change, coastal land-use change, and habitat modification. We have developed and demonstrated a geospatial modeling a...

  6. Confluence at distal end of multiple coronary artery fistulae: two cases treated with interventional approach

    Institute of Scientific and Technical Information of China (English)

    SHEN Xiang-qian; HU Xin-qun; LI Jiang; ZHOU Tao; FANG Zhen-fei; ZHOU Sheng-hua; TANG Jian-jun; QI Shu-shan; L(U) Xiao-ling

    2008-01-01

    @@ Coronarv artery fistula(CAF), an uncommon congenital heart disease,often results in myocardial ischemia.1-3 In the last two decades,there are some reports about interventional treatment of CAF,4-6but few on transcatheter treatment of multiple CAFS.With different interventional procedures, we treated successfully two cases of percutaneous closure of two multiple CAFs which were confluent at the distal ends.

  7. Multiple Religious Belonging in the Netherlands: An Empirical Approach to Hybrid Religiosity

    OpenAIRE

    Berghuijs Joantine

    2017-01-01

    Dutch society is highly secularized in terms of decreasing church membership and church attendance. Meanwhile, there are many ‘religious creatives’ who fulfil their need for meaning by using multiple religious sources. This paper presents an empirical investigation into the occurrence and nature of hybrid religion in the Netherlands, seen as ‘multiple religious belonging’ (MRB). After a number of global indications of the importance of MRB, this is the first attempt to quantify and detail MRB...

  8. A New Approach to Design Graph Based Search Engine for Multiple Domains Using Different Ontologies

    CERN Document Server

    Mukhopadhyay, Debajyoti

    2011-01-01

    Search Engine has become a major tool for searching any information from the World Wide Web (WWW). While searching the huge digital library available in the WWW, every effort is made to retrieve the most relevant results. But in WWW majority of the Web pages are in HTML format and there are no such tags which tells the crawler to find any specific domain. To find more relevant result we use Ontology for that particular domain. If we are working with multiple domains then we use multiple ontologies. Now in order to design a domain specific search engine for multiple domains, crawler must crawl through the domain specific Web pages in the WWW according to the predefined ontologies.

  9. One-dimensional multiple-well oscillators: A time-dependent quantum mechanical approach

    Indian Academy of Sciences (India)

    Neetu Gupta; Amlan K Roy; B M Deb

    2002-10-01

    Time-dependent Schrödinger equation (TDSE) is solved numerically to calculate the ground- and first three excited-state energies, expectation values $\\langle x^{2j}\\rangle$, $j=1,2,\\ldots,6$ and probability densities of quantum mechanical multiple-well oscillators. An imaginary-time evolution technique, coupled with the minimization of energy expectation value to reach a global minimum, subject to orthogonality constraint (for excited states) has been employed. Pseudodegeneracy in symmetric, deep multiple-well potentials, probability densities and the effect of an asymmetry parameter on pseudodegeneracy are discussed.

  10. Robust Generation of Dynamic Data Structure Visualizations with Multiple Interaction Approaches

    Science.gov (United States)

    Cross, James H., II; Hendrix, T. Dean; Umphress, David A.; Barowski, Larry A.; Jain, Jhilmil; Montgomery, Lacey N.

    2009-01-01

    jGRASP has three integrated approaches for interacting with its dynamic viewers for data structures: debugger, workbench, and text-based interactions that allow individual Java statements and expressions to be executed/evaluated. These approaches can be used together to provide a complementary set of interactions with the dynamic viewers. Data…

  11. Multiple chiral doublet candidate nucleus $^{105}$Rh in a relativistic mean-field approach

    CERN Document Server

    Li, Jian; Meng, J; 10.1103/PhysRevC.83.037301

    2011-01-01

    Following the reports of two pairs of chiral doublet bands observed in $^{105}$Rh, the adiabatic and configuration-fixed constrained triaxial relativistic mean-field (RMF) calculations are performed to investigate their triaxial deformations with the corresponding configuration and the possible multiple chiral doublet (M$\\chi$D) phenomenon. The existence of M$\\chi$D phenomenon in $^{105}$Rh is highly expected.

  12. Intradistrict Resource Reallocation for Latino English Language Learners: An Exploratory Multiple Case Study Approach

    Science.gov (United States)

    Jimenez-Castellanos, Oscar; Rodriguez, James L.

    2009-01-01

    This article seeks to contribute to the recent discussion regarding school finance, teacher quality, and English language learners (ELLs) based on a comparative study within a school district with a significant ELL population. The study described in this article utilizes an exploratory multiple case study methodology to examine the complex…

  13. Economic Evaluations of Targeted Therapy and Risk-Stratified Treatment Approaches in Multiple Myeloma

    NARCIS (Netherlands)

    J.G. Gaultney (Jennifer G.)

    2014-01-01

    markdownabstract__Abstract__ Multiple myeloma (MM) is a malignant plasma cell disorder accounting for 1% of all cancer diagnoses worldwide and 13% of all hematologic malignancies [1]. Worldwide, the incidence of MM is 0.4 to 5 per 100,000 people per year [2]. Incidence rates are higher among males

  14. Scheduling System for Multiple Unmanned Aerial Vehicles in Indoor Environments Using the CSP Approach

    DEFF Research Database (Denmark)

    Park, Youngsoo; Khosiawan, Yohanes; Moon, Ilkyeong

    2016-01-01

    In recent years there has been an increased demand in use of multiple unmanned aerial vehicles (UAVs) for surveillance and material handling tasks in indoor environments. However, only a limited number of studies have been reported on UAV scheduling in an indoor 3D environment. This paper presents...

  15. Using a Multiple Perspectives Framework: A Methodological Approach to Analyse Complex and Contradictory Interview Data

    Science.gov (United States)

    Santoro, Ninetta

    2014-01-01

    In this article I describe how a multiple perspectives framework drawn from the field of social work informed my analysis of interview data obtained from Australian preservice teachers who had gone on an international study trip. One incident recounted differently by three separate interviewees meant that the sometimes-similar and…

  16. Mechanisms of Oxidative Damage in Multiple Sclerosis and a Cell Therapy Approach to Treatment

    Directory of Open Access Journals (Sweden)

    Jonathan Witherick

    2011-01-01

    Full Text Available Although significant advances have recently been made in the understanding and treatment of multiple sclerosis, reduction of long-term disability remains a key goal. Evidence suggests that inflammation and oxidative stress within the central nervous system are major causes of ongoing tissue damage in the disease. Invading inflammatory cells, as well as resident central nervous system cells, release a number of reactive oxygen and nitrogen species which cause demyelination and axonal destruction, the pathological hallmarks of multiple sclerosis. Reduction in oxidative damage is an important therapeutic strategy to slow or halt disease processes. Many drugs in clinical practice or currently in trial target this mechanism. Cell-based therapies offer an alternative source of antioxidant capability. Classically thought of as being important for myelin or cell replacement in multiple sclerosis, stem cells may, however, have a more important role as providers of supporting factors or direct attenuators of the disease. In this paper we focus on the antioxidant properties of mesenchymal stem cells and discuss their potential importance as a cell-based therapy for multiple sclerosis.

  17. Symptomatic therapy in multiple sclerosis: a review for a multimodal approach in clinical practice

    DEFF Research Database (Denmark)

    de Sa, João Carlos Correia; Airas, Laura; Bartholome, Emmanuel;

    2011-01-01

    As more investigations into factors affecting the quality of life of patients with multiple sclerosis (MS) are undertaken, it is becoming increasingly apparent that certain comorbidities and associated symptoms commonly found in these patients differ in incidence, pathophysiology and other factors...

  18. Enriching Student Concept Images: Teaching and Learning Fractions through a Multiple-Embodiment Approach

    Science.gov (United States)

    Zhang, Xiaofen; Clements, M. A.; Ellerton, Nerida F.

    2015-01-01

    This study investigated how fifth-grade children's concept images of the unit fractions represented by the symbols 1/2, 1/3/ and 1/4 changed as a result of their participation in an instructional intervention based on multiple embodiments of fraction concepts. The participants' concept images were examined through pre- and post-teaching written…

  19. Caracterización Clínica y Paraclínica de una Cohorte de pacientes con diagnostico de esclerosis sistémica temprana en la ciudad de Bogotá que asistieron a la consulta externa de la Unidad de Reumatología de la Universidad Nacional de Colombia entre 2010 y 2014

    OpenAIRE

    Martínez Lozano, Diego Javier

    2015-01-01

    La esclerosis sistémica en es una enfermedad rara del tejido conectivo, que se caracteriza por deposito excesivo de colágeno y fibrosis progresiva de la piel, que puede ser órgano especifica. Objetivo: Describir el comportamiento clínico y paraclínico de una cohorte de pacientes con esclerosis sistémica temprana de la Universidad Nacional de Colombia y establecer asociaciones entre las diferentes variables, y de la misma manera evaluar el desarrollo de complicaciones y describi...

  20. An integrated modeling approach to support management decisions of coupled groundwater-agricultural systems under multiple uncertainties

    Science.gov (United States)

    Hagos Subagadis, Yohannes; Schütze, Niels; Grundmann, Jens

    2015-04-01

    The planning and implementation of effective water resources management strategies need an assessment of multiple (physical, environmental, and socio-economic) issues, and often requires new research in which knowledge of diverse disciplines are combined in a unified methodological and operational frameworks. Such integrative research to link different knowledge domains faces several practical challenges. Such complexities are further compounded by multiple actors frequently with conflicting interests and multiple uncertainties about the consequences of potential management decisions. A fuzzy-stochastic multiple criteria decision analysis tool was developed in this study to systematically quantify both probabilistic and fuzzy uncertainties associated with complex hydrosystems management. It integrated physical process-based models, fuzzy logic, expert involvement and stochastic simulation within a general framework. Subsequently, the proposed new approach is applied to a water-scarce coastal arid region water management problem in northern Oman, where saltwater intrusion into a coastal aquifer due to excessive groundwater extraction for irrigated agriculture has affected the aquifer sustainability, endangering associated socio-economic conditions as well as traditional social structure. Results from the developed method have provided key decision alternatives which can serve as a platform for negotiation and further exploration. In addition, this approach has enabled to systematically quantify both probabilistic and fuzzy uncertainties associated with the decision problem. Sensitivity analysis applied within the developed tool has shown that the decision makers' risk aversion and risk taking attitude may yield in different ranking of decision alternatives. The developed approach can be applied to address the complexities and uncertainties inherent in water resources systems to support management decisions, while serving as a platform for stakeholder participation.

  1. [Response to treatment with interferon beta in patients with multiple sclerosis. Validation of the Rio Score].

    Science.gov (United States)

    Rio, J; Rovira, A; Blanco, Y; Sainz, A; Perkal, H; Robles, R; Ramio-Torrenta, Ll; Diaz, R M; Arroyo, R; Urbaneja, P; Fernandez, O; Garcia-Merino, J A; Reyes, M P; Oreja-Guevara, C; Prieto, J M; Izquierdo, G; Olascoaga, J; Alvarez-Cermeno, J C; Simon, E; Pujal, B; Comabella, M; Montalban, X

    2016-08-16

    Introduccion. Se han propuesto diferentes criterios de respuesta al tratamiento con interferon beta, y el Rio Score es uno de los mas utilizados. El objetivo de este estudio fue validar la utilidad del Rio Score en una cohorte independiente. Pacientes y metodos. Estudio multicentrico, prospectivo y longitudinal de pacientes con esclerosis multiple remitente recurrente tratados con interferon beta. Los pacientes fueron clasificados basandose en la presencia de brotes, lesiones activas (nuevas en T2 o lesiones que captaban gadolinio) en la resonancia magnetica, incremento confirmado de la discapacidad o combinaciones de estas variables (brotes, incremento en la Expanded Disability Status Scale y lesiones activas) tras un año de tratamiento. Se utilizo un analisis de regresion con el fin de identificar las variables de prediccion de respuesta despues de un seguimiento de tres años. Resultados. Se incluyo a 249 pacientes con esclerosis multiple remitente recurrente. El modelo logistico confirmo que la presencia de dos (odds ratio = 6,6; IC 95% = 2,7-16,1; p discapacidad durante el tratamiento con interferon beta.

  2. [Factors associated to the work situation of patients with multiple sclerosis].

    Science.gov (United States)

    Cores, Evangelina V; Vanotti, Sandra; Burin, Débora I; Politis, Daniel G; Villa, Andrés

    2014-02-16

    Introduccion. La esclerosis multiple es una enfermedad neurologica desmielinizante que suele provocar trastornos motrices, perceptivos, afectivos y cognitivos a quienes la padecen. Estos sintomas pueden llevar a la persona a perder su empleo, y disminuir la calidad de vida del paciente y sus familiares. Objetivo. Revisar estudios sobre variables demograficas, clinicas, cognitivas, psiquiatricas, laborales y sociales asociadas con la situacion laboral. Desarrollo. Estudios transversales y longitudinales han detectado variables relacionadas con el desempleo. Las investigaciones empiricas muestran una influencia clara de la discapacidad fisica, la fatiga y el curso de la enfermedad sobre la situacion laboral. Sin embargo, el genero, la depresion, la edad, la duracion de la enfermedad y las variables cognitivas no poseen el mismo grado de evidencia. Caracteristicas de la ocupacion, como discriminacion laboral, actitud del empleador, leyes laborales, actitud de los compañeros de trabajo y dificultades en el transporte han sido variables poco consideradas. Conclusiones. Muchos de los factores que determinan la perdida de empleo en un paciente con esclerosis multiple pueden identificarse a tiempo para poder modificarlos o compensarlos. Los conocimientos aportados por los estudios reseñados permiten detectar a aquellos pacientes que se encuentran en riesgo de perder su empleo para realizar intervenciones posibles con el objetivo de prevenir esta situacion. En particular, el perfil de vulnerabilidad incluye alta discapacidad fisica y fatiga, curso progresivo de la enfermedad y presencia de deterioro cognitivo, entre otros.

  3. NEW APPROACHES FOR COMPUTING DYNAMIC LOAD-CARRYING CAPACITY OF MULTIPLE COOPERATING ROBOTIC MANIPULATORS

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    A novel unified method for computing the dynamic load-carrying capacity(DLCC) of multiple cooperating robotic manipulators is developed.In this method,the kinematic constraints and the governing dynamic equations of the multiple robot system are formulated in the joint space by using the method of transference of dependence from one set of generalized coordinates to another,and the virtual work principle,which includes the readily available dynamics and joint torques of individual manipulators,and the dynamic of payload.Based on this dynamic model,the upper limit of the DLCC at any points on a given trajectory is obtained by solving a small-size linear programming problem.This method is conceptually straightforward,and it is applicable also to the cases of multi-fingered robot hands and multi-legged walking machines.

  4. CRISPR-PCS: a powerful new approach to inducing multiple chromosome splitting in Saccharomyces cerevisiae

    Science.gov (United States)

    Sasano, Yu; Nagasawa, Koki; Kaboli, Saeed; Sugiyama, Minetaka; Harashima, Satoshi

    2016-01-01

    PCR-mediated chromosome splitting (PCS) was developed in the yeast Saccharomyces cerevisiae. It is based on homologous recombination and enables division of a chromosome at any point to form two derived and functional chromosomes. However, because of low homologous recombination activity, PCS is limited to a single site at a time, which makes the splitting of multiple loci laborious and time-consuming. Here we have developed a highly efficient and versatile chromosome engineering technology named CRISPR-PCS that integrates PCS with the novel genome editing CRISPR/Cas9 system. This integration allows PCS to utilize induced double strand breaks to activate homologous recombination. CRISPR-PCS enhances the efficiency of chromosome splitting approximately 200-fold and enables generation of simultaneous multiple chromosome splits. We propose that CRISPR-PCS will be a powerful tool for breeding novel yeast strains with desirable traits for specific industrial applications and for investigating genome function. PMID:27530680

  5. Adaptive management of applications across multiple clouds: The SeaClouds Approach

    Directory of Open Access Journals (Sweden)

    Antonio Brogi

    2015-04-01

    Full Text Available How to deploy and manage, in an efficient and adaptive way, complex applications across multiple heterogeneous cloud platforms is one of the problems that have emerged with the cloud revolution. In this paper we present context, motivations and objectives of the EU research project SeaClouds, which aims at enabling a seamless adaptive multi-cloud management of complex applications by supporting the distribution, monitoring and migration of application modules over multiple heterogeneous cloud platforms. After positioning SeaClouds with respect to related cloud initiatives, we present the SeaClouds architecture and discuss some of its aspect, such as the use of the OASIS standard TOSCA and the compatibility with the OASIS CAMP initiative.

  6. A Novel Approach to Beam Steering Using Arrays Composed of Multiple Unique Radiating Modes

    Science.gov (United States)

    Labadie, Nathan Richard

    Phased array antennas have found wide application in both radar and wireless communications systems particularly as implementation costs continue to decrease. The primary advantages of electronically scanned arrays are speed of beam scan and versatility of beamforming compared to mechanically scanned fixed beam antennas. These benefits come at the cost of a few well known design issues including element pattern rolloff and mutual coupling between elements. Our primary contribution to the field of research is the demonstration of significant improvement in phased array scan performance using multiple unique radiating modes. In short, orthogonal radiating modes have minimal coupling by definition and can also be generated with reduced rolloff at wide scan angles. In this dissertation, we present a combination of analysis, full-wave electromagnetic simulation and measured data to support our claims. The novel folded ring resonator (FRR) antenna is introduced as a wideband and multi-band element embedded in a grounded dielectric substrate. Multiple radiating modes of a small ground plane excited by a four element FRR array were also investigated. A novel hemispherical null steering antenna composed of two collocated radiating elements, each supporting a unique radiating mode, is presented in the context of an anti-jam GPS receiver application. Both the antenna aperture and active feed network were fabricated and measured showing excellent agreement with analytical and simulated data. The concept of using an antenna supporting multiple radiating modes for beam steering is also explored. A 16 element hybrid linear phased array was fabricated and measured demonstrating significantly improved scan range and scanned gain compared to a conventional phased array. This idea is expanded to 2 dimensional scanning arrays by analysis and simulation of a hybrid phased array composed of novel multiple mode monopole on patch antenna sub-arrays. Finally, we fabricated and

  7. Practice-oriented optical thin film growth simulation via multiple scale approach

    Energy Technology Data Exchange (ETDEWEB)

    Turowski, Marcus, E-mail: m.turowski@lzh.de [Laser Zentrum Hannover e.V., Hollerithallee 8, Hannover 30419 (Germany); Jupé, Marco [Laser Zentrum Hannover e.V., Hollerithallee 8, Hannover 30419 (Germany); QUEST: Centre of Quantum Engineering and Space-Time Research, Leibniz Universität Hannover (Germany); Melzig, Thomas [Fraunhofer Institute for Surface Engineering and Thin Films IST, Bienroder Weg 54e, Braunschweig 30108 (Germany); Moskovkin, Pavel [Research Centre for Physics of Matter and Radiation (PMR-LARN), University of Namur (FUNDP), 61 rue de Bruxelles, Namur 5000 (Belgium); Daniel, Alain [Centre for Research in Metallurgy, CRM, 21 Avenue du bois Saint Jean, Liège 4000 (Belgium); Pflug, Andreas [Fraunhofer Institute for Surface Engineering and Thin Films IST, Bienroder Weg 54e, Braunschweig 30108 (Germany); Lucas, Stéphane [Research Centre for Physics of Matter and Radiation (PMR-LARN), University of Namur (FUNDP), 61 rue de Bruxelles, Namur 5000 (Belgium); Ristau, Detlev [Laser Zentrum Hannover e.V., Hollerithallee 8, Hannover 30419 (Germany); QUEST: Centre of Quantum Engineering and Space-Time Research, Leibniz Universität Hannover (Germany)

    2015-10-01

    Simulation of the coating process is a very promising approach for the understanding of thin film formation. Nevertheless, this complex matter cannot be covered by a single simulation technique. To consider all mechanisms and processes influencing the optical properties of the growing thin films, various common theoretical methods have been combined to a multi-scale model approach. The simulation techniques have been selected in order to describe all processes in the coating chamber, especially the various mechanisms of thin film growth, and to enable the analysis of the resulting structural as well as optical and electronic layer properties. All methods are merged with adapted communication interfaces to achieve optimum compatibility of the different approaches and to generate physically meaningful results. The present contribution offers an approach for the full simulation of an Ion Beam Sputtering (IBS) coating process combining direct simulation Monte Carlo, classical molecular dynamics, kinetic Monte Carlo, and density functional theory. The simulation is performed exemplary for an existing IBS-coating plant to achieve a validation of the developed multi-scale approach. Finally, the modeled results are compared to experimental data. - Highlights: • A model approach for simulating an Ion Beam Sputtering (IBS) process is presented. • In order to combine the different techniques, optimized interfaces are developed. • The transport of atomic species in the coating chamber is calculated. • We modeled structural and optical film properties based on simulated IBS parameter. • The modeled and the experimental refractive index data fit very well.

  8. A UNIVERSAL APPROACH FOR CONTINUOUS OR DISCRETE NONLINEAR PROGRAMMINGS WITH MULTIPLE VARIABLES AND CONSTRAINTS

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    A universal numerical approach for nonlinear mathematic programming problems is presented with an application of ratios of first-order differentials/differences of objective functions to constraint functions with respect to design variables. This approach can be efficiently used to solve continuous and, in particular, discrete programmings with arbitrary design variables and constraints. As a search method, this approach requires only computations of the functions and their partial derivatives or differences with respect to design variables, rather than any solution of mathematic equations. The present approach has been applied on many numerical examples as well as on some classical operational problems such as one-dimensional and two-dimensional knap-sack problems, one-dimensional and two-dimensional resource-distribution problems, problems of working reliability of composite systems and loading problems of machine, and more efficient and reliable solutions are obtained than traditional methods. The present approach can be used without limitation of modeling scales of the problem. Optimum solutions can be guaranteed as long as the objective function,constraint functions and their first-order derivatives/differences exist in the feasible domain or feasible set. There are no failures of convergence and instability when this approach is adopted.

  9. Climate change, livelihoods and the multiple determinants of water adequacy: two approaches at regional to global scale

    Science.gov (United States)

    Lissner, Tabea; Reusser, Dominik

    2015-04-01

    Inadequate access to water is already a problem in many regions of the world and processes of global change are expected to further exacerbate the situation. Many aspects determine the adequacy of water resources: beside actual physical water stress, where the resource itself is limited, economic and social water stress can be experienced if access to resource is limited by inadequate infrastructure, political or financial constraints. To assess the adequacy of water availability for human use, integrated approaches are needed that allow to view the multiple determinants in conjunction and provide sound results as a basis for informed decisions. This contribution proposes two parts of an integrated approach to look at the multiple dimensions of water scarcity at regional to global scale. These were developed in a joint project with the German Development Agency (GIZ). It first outlines the AHEAD approach to measure Adequate Human livelihood conditions for wEll-being And Development, implemented at global scale and at national resolution. This first approach allows viewing impacts of climate change, e.g. changes in water availability, within the wider context of AHEAD conditions. A specific focus lies on the uncertainties in projections of climate change and future water availability. As adequate water access is not determined by water availability alone, in a second step we develop an approach to assess the water requirements for different sectors in more detail, including aspects of quantity, quality as well as access, in an integrated way. This more detailed approach is exemplified at region-scale in Indonesia and South Africa. Our results show that in many regions of the world, water scarcity is a limitation to AHEAD conditions in many countries, regardless of differing modelling output. The more detailed assessments highlight the relevance of additional aspects to assess the adequacy of water for human use, showing that in many regions, quality and

  10. NEWTONIAN IMPERIALIST COMPETITVE APPROACH TO OPTIMIZING OBSERVATION OF MULTIPLE TARGET POINTS IN MULTISENSOR SURVEILLANCE SYSTEMS

    Directory of Open Access Journals (Sweden)

    A. Afghan-Toloee

    2013-09-01

    Full Text Available The problem of specifying the minimum number of sensors to deploy in a certain area to face multiple targets has been generally studied in the literatures. In this paper, we are arguing the multi-sensors deployment problem (MDP. The Multi-sensor placement problem can be clarified as minimizing the cost required to cover the multi target points in the area. We propose a more feasible method for the multi-sensor placement problem. Our method makes provision the high coverage of grid based placements while minimizing the cost as discovered in perimeter placement techniques. The NICA algorithm as improved ICA (Imperialist Competitive Algorithm is used to decrease the performance time to explore an enough solution compared to other meta-heuristic schemes such as GA, PSO and ICA. A three dimensional area is used for clarify the multiple target and placement points, making provision x, y, and z computations in the observation algorithm. A structure of model for the multi-sensor placement problem is proposed: The problem is constructed as an optimization problem with the objective to minimize the cost while covering all multiple target points upon a given probability of observation tolerance.

  11. Estudio en fase I de utilización de las células madre de médula ósea autólogas en pacientes con esclerosis lateral amiotrófica

    OpenAIRE

    Blanquer Blanquer, Miguel

    2012-01-01

    Nuestro objetivo fue comprobar la seguridad de la infusión intraespinal de células mononucleadas de médula ósea autóloga (BMNCs) y buscar signos de neurotrofismo celular en pacientes con esclerosis lateral amiotrófica (ELA). Realizamos un ensayo fase I, infundiendo BMNCs en el cordón posterior medular. La seguridad se definió como la ausencia de eventos adversos severos relacionados con el tratamiento. Incluimos once pacientes. No hubo eventos adversos severos relacionados con el tratamiento....

  12. Caracterización clínica, inmunológica y hallazgos capilaroscopicos de esclerosis sistémica, y asociación con compromiso pulmonar en una población Colombiana

    OpenAIRE

    Gil Calderón, Diana Rocío

    2013-01-01

    Introducción: La esclerosis sistémica es una enfermedad crónica, multisistemica y muy heterogénea en su presentación y compromiso de órgano durante su evolución, tales como hipertensión pulmonar arterial, enfermedad pulmonar intersticial difusa, ulceras digitales, compromiso cardiaco, gastrointestinal y renal, dicha variación está enmarcada con la etnicidad. Nuevos criterios han sido propuestos con el objetivo de detectarla en estadios tempranos y mejorar el pronóstico. Objetivos: Describir l...

  13. Viviendo con esclerosis sistémica y enfermedad pulmonar intersticial: impacto en el significado subjetivo de actividad física y la calidad de vida, desde la perspectiva de mujeres con esta patología

    OpenAIRE

    Murillo Rodríguez, Laura Eugenia

    2014-01-01

    Tesis texto completo. Determina que la Esclerosis Sistémica (ES) es una enfermedad inflamatoria crónica del tejido conectivo, que se caracteriza por la producción excesiva de colágeno en la piel y en los órganos internos tales como pulmones, corazón, riñón y tracto gastrointestinal. por la hiperreactividad vascular obliterante (obstruidos) y los fenómenos microvasculares (afectación de la red capilar que incluye vasos sanguíneos y arterias). El deterioro de estos órganos produce un amplio ...

  14. Asociación de Antígenos Leucocitarios humanos de clase II (HLA-II) con Esclerosis Sistémica Progresiva en una cohorte de pacientes colombianos

    OpenAIRE

    Jaramillo Arroyave, Daniel

    2014-01-01

    Introducción: La Esclerosis Sistémica (ES) es una enfermedad inflamatoria crónica de etiología desconocida caracterizada por fibrosis de piel y órganos internos, además de proliferación micro vascular y fenómenos de autoinmunidad. Su patogénesis sigue en estudio y se ha determinado la importancia que juega la parte genética en su desarrollo. El HLA de clase II ha resultado ser un parámetro importante desde el punto de vista de probabilidad de desarrollo de la enfermedad, perfil clínico y sero...

  15. Megadosis de metilprednisolona oral frente a intravenosa para el brote de esclerosis múltiple comparación de la eficacia clínica y radiológica /

    OpenAIRE

    Ramo Tello, Cristina

    2013-01-01

    La majoria de pacients amb esclerosi múltiple (EM), patiran, sobretot al principi de la seva malaltia, episodis subaguts de dèficit neurològic (brots), dels que es recuperaran en major o menor mesura. Minimitzar el risc de patir un brot és el fonament en el qual es basen les teràpies actuals per a l'EM, si bé cap de les disponibles és capaç d'evitar-lo completament, per la qual cosa, el tractament adequat del brot, que persegueix escurçar la seva durada y millorar la seva recuperació, continu...

  16. Análisis de la capacidad vital forzada como indicador de inicio de ventilación no invasiva en enfermos con esclerosis lateral amiotrófica

    OpenAIRE

    Martínez González, Daniel

    2014-01-01

    La Esclerosis lateral amiotrófica (ELA) es una enfermedad neurodegenerativa de causa desconocida que se caracteriza por la pérdida de neuronas motoras en la médula espinal, el tronco cerebral y la corteza motora. Como consecuencia se produce un debilitamiento progresivo de los músculos de las extremidades, bulbares, torácicos y abdominales. La consecuencia directa de este hecho tiene repercusiones sobre la morbimortalidad en los pacientes con ELA. Ésta se constituye principalmente por problem...

  17. Evaluaci??n de la fuerza muscular y de los efectos sobre la misma de un programa de entrenamiento y de desentrenamiento en afectados por esclerosis m??ltiple de Castilla y Le??n

    OpenAIRE

    Medina P??rez, Carlos

    2012-01-01

    210 p. Con este trabajo nos hemos propuesto evaluar la fuerza muscular, observar los efectos de un programa de entrenamiento de fuerza de doce semanas de duraci??n, realizado con una intensidad entre el 35% y el 70% de la fuerza isom??trica m??xima y determinar los efectos del mismo durante un periodo de desentrenamiento de doce semanas, en los afectados por esclerosis m??ltiple en la Comunidad Aut??noma de Castilla y Le??n. En base a ello, las principales conclusiones de este trabajo son:...

  18. Métodos fisioterápicos y de actividad física en la prevención de caídas de pacientes con esclerosis múltiple

    OpenAIRE

    Gorria Redondo, Aurkene

    2014-01-01

    Introducción: La esclerosis múltiple es una enfermedad neurológica que se caracteriza por la inflamación y destrucción de la mielina del sistema nervioso central. El riesgo de caídas de estos pacientes es relativamente alto, la mayoría suceden durante la marcha. Objetivos: Comprobar la efectividad de una fisioterapia basada en la actividad física en la mejora de la calidad de la marcha y disminución del riesgo de caídas en pacientes con EM, así como identificar...

  19. A hybrid approach to simulate multiple photon scattering in X-ray imaging

    Energy Technology Data Exchange (ETDEWEB)

    Freud, N. [CNDRI, Laboratory of Nondestructive Testing using Ionizing Radiations, INSA-Lyon Scientific and Technical University, Bat. Antoine de Saint-Exupery, 20, avenue Albert Einstein, 69621 Villeurbanne Cedex (France)]. E-mail: nicolas.freud@insa-lyon.fr; Letang, J.-M. [CNDRI, Laboratory of Nondestructive Testing using Ionizing Radiations, INSA-Lyon Scientific and Technical University, Bat. Antoine de Saint-Exupery, 20, avenue Albert Einstein, 69621 Villeurbanne Cedex (France); Babot, D. [CNDRI, Laboratory of Nondestructive Testing using Ionizing Radiations, INSA-Lyon Scientific and Technical University, Bat. Antoine de Saint-Exupery, 20, avenue Albert Einstein, 69621 Villeurbanne Cedex (France)

    2005-01-01

    A hybrid simulation approach is proposed to compute the contribution of scattered radiation in X- or {gamma}-ray imaging. This approach takes advantage of the complementarity between the deterministic and probabilistic simulation methods. The proposed hybrid method consists of two stages. Firstly, a set of scattering events occurring in the inspected object is determined by means of classical Monte Carlo simulation. Secondly, this set of scattering events is used as a starting point to compute the energy imparted to the detector, with a deterministic algorithm based on a 'forced detection' scheme. For each scattering event, the probability for the scattered photon to reach each pixel of the detector is calculated using well-known physical models (form factor and incoherent scattering function approximations, in the case of Rayleigh and Compton scattering respectively). The results of the proposed hybrid approach are compared to those obtained with the Monte Carlo method alone (Geant4 code) and found to be in excellent agreement. The convergence of the results when the number of scattering events increases is studied. The proposed hybrid approach makes it possible to simulate the contribution of each type (Compton or Rayleigh) and order of scattering, separately or together, with a single PC, within reasonable computation times (from minutes to hours, depending on the number of pixels of the detector). This constitutes a substantial benefit, compared to classical simulation methods (Monte Carlo or deterministic approaches), which usually requires a parallel computing architecture to obtain comparable results.

  20. A three-sample multiple-recapture approach to census population estimation with heterogeneous catchability.

    Science.gov (United States)

    Derroch, J N; Fienberg, S E; Glonek, G F; Junker, B W

    1993-09-01

    "A central assumption in the standard capture-recapture approach to the estimation of the size of a closed population is the homogeneity of the 'capture' probabilities. In this article we develop an approach that allows for varying susceptibility to capture through individual parameters using a variant of the Rasch model from psychological measurement situations. Our approach requires an additional recapture. In the context of census undercount estimation, this requirement amounts to the use of a second independent sample or alternative data source to be matched with census and Post-Enumeration Survey (PES) data.... We illustrate [our] models and their estimation using data from a 1988 dress-rehearsal study for the 1990 census conducted by the U.S. Bureau of the Census, which explored the use of administrative data as a supplement to the PES. The article includes a discussion of extensions and related models."

  1. Multiple subtropical stratospheric intrusions over Reunion Island: Observational, Lagrangian, and Eulerian numerical modeling approaches

    Science.gov (United States)

    Vérèmes, H.; Cammas, J.-P.; Baray, J.-L.; Keckhut, P.; Barthe, C.; Posny, F.; Tulet, P.; Dionisi, D.; Bielli, S.

    2016-12-01

    Signatures of multiple stratospheric intrusions were observed on simultaneous and collocated ozone and water vapor profiles retrieved by lidars and radiosondes at the Maïdo Observatory, Reunion Island (21°S, 55°E, 2160 m above sea level), during MAïdo LIdar Calibration CAmpaign in April 2013. A singular structure of the ozone vertical profile with three peaks (in excess of 90 ppbv, at 8, 10, and 13 km altitude) embedded in a thick dry layer of air suggested stratospheric intrusions with multiple origins. The hypothesis is corroborated by a synoptic analysis based on re-analyses. European Centre for Medium-Range Weather Forecasts ERA-Interim temporal series associated with 5 days Lagrangian back trajectories initialized on each ozone peak allows to capture their stratospheric origin. The ozone peak at the lowest altitude is associated with an irreversible tropopause folding process along the polar jet stream during an extratropical cutoff low formation. Simultaneous lidar water vapor profiles of this peak show that the anticorrelation with ozone has been removed, due to mixing processes. Back trajectories indicate that the two other ozone peaks observed at higher altitudes are associated with the dynamics of the subtropical jet stream and the lower stratosphere. The observations confirm the recent stratospheric origins. The highest ozone peak is explained by the horizontal distribution of the intrusion. Use of a Lagrangian Reverse Domain Filling model and of the Meso-NH Eulerian mesoscale model with a passive stratospheric tracer allow to further document the stratosphere-troposphere transport processes and to describe the detailed potential vorticity and ozone structures in which are embedded in the observed multiple stratospheric intrusions.

  2. Exploring multiple intelligences theory in the context of science education: An action research approach

    Science.gov (United States)

    Goodnough, Karen Catherine

    2000-10-01

    Since the publication of Frames of Mind: The Theory in Practice, multiple intelligences, theory (Gardner, 1983) has been used by practitioners in a variety of ways to make teaching and learning more meaningful. However, little attention has been focused on exploring the potential of the theory for science teaching and learning. Consequently, this research study was designed to: (1) explore Howard Gardner's theory of multiple intelligences (1983) and its merit for making science teaching and learning more meaningful; (2) provide a forum for teachers to engage in critical self-reflection about their theory and practice in science education; (3) study the process of action research in the context of science education; and (4) describe the effectiveness of collaborative action research as a framework for teacher development and curriculum development. The study reports on the experiences of four teachers (two elementary teachers, one junior high teacher, and one high school teacher) and myself, a university researcher-facilitator, as we participated in a collaborative action research project. The action research group held weekly meetings over a five-month period (January--May, 1999). The inquiry was a qualitative case study (Stake, 1994) that aimed to understand the perspectives of those directly involved. This was achieved by using multiple methods to collect data: audiotaped action research meetings, fieldnotes, semi-structured interviews, journal writing, and concept mapping. All data were analysed on an ongoing basis. Many positive outcomes resulted from the study in areas such as curriculum development, teacher development, and student learning in science. Through the process of action research, research participants became more reflective about their practice and thus, enhanced their pedagogical content knowledge (Shulman, 1987) in science. Students became more engaged in learning science, gained a greater understanding of how they learn, and experienced a

  3. Hybrid approaches for multiple-species stochastic reaction–diffusion models

    Energy Technology Data Exchange (ETDEWEB)

    Spill, Fabian, E-mail: fspill@bu.edu [Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215 (United States); Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (United States); Guerrero, Pilar [Department of Mathematics, University College London, Gower Street, London WC1E 6BT (United Kingdom); Alarcon, Tomas [Centre de Recerca Matematica, Campus de Bellaterra, Edifici C, 08193 Bellaterra (Barcelona) (Spain); Departament de Matemàtiques, Universitat Atonòma de Barcelona, 08193 Bellaterra (Barcelona) (Spain); Maini, Philip K. [Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford OX2 6GG (United Kingdom); Byrne, Helen [Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford OX2 6GG (United Kingdom); Computational Biology Group, Department of Computer Science, University of Oxford, Oxford OX1 3QD (United Kingdom)

    2015-10-15

    Reaction–diffusion models are used to describe systems in fields as diverse as physics, chemistry, ecology and biology. The fundamental quantities in such models are individual entities such as atoms and molecules, bacteria, cells or animals, which move and/or react in a stochastic manner. If the number of entities is large, accounting for each individual is inefficient, and often partial differential equation (PDE) models are used in which the stochastic behaviour of individuals is replaced by a description of the averaged, or mean behaviour of the system. In some situations the number of individuals is large in certain regions and small in others. In such cases, a stochastic model may be inefficient in one region, and a PDE model inaccurate in another. To overcome this problem, we develop a scheme which couples a stochastic reaction–diffusion system in one part of the domain with its mean field analogue, i.e. a discretised PDE model, in the other part of the domain. The interface in between the two domains occupies exactly one lattice site and is chosen such that the mean field description is still accurate there. In this way errors due to the flux between the domains are small. Our scheme can account for multiple dynamic interfaces separating multiple stochastic and deterministic domains, and the coupling between the domains conserves the total number of particles. The method preserves stochastic features such as extinction not observable in the mean field description, and is significantly faster to simulate on a computer than the pure stochastic model. - Highlights: • A novel hybrid stochastic/deterministic reaction–diffusion simulation method is given. • Can massively speed up stochastic simulations while preserving stochastic effects. • Can handle multiple reacting species. • Can handle moving boundaries.

  4. Segmenting Multiple Sclerosis Lesions Using a Spatially Constrained K-Nearest Neighbour Approach

    DEFF Research Database (Denmark)

    Lyksborg, Mark; Larsen, Rasmus; Sørensen, Per Soelberg;

    2012-01-01

    We propose a method for the segmentation of Multiple Sclerosis lesions. The method is based on probability maps derived from a K-Nearest Neighbours classification. These are used as a non parametric likelihood in a Bayesian formulation with a prior that assumes connectivity of neighbouring voxels......, the diffusion MRI measures of Fractional Anisotropy (FA), Mean Diffusivity (MD) and several spatial features. Results show a benefit from the inclusion of diffusion primarily to the most difficult cases. Results shows that combining probabilistic K-Nearest Neighbour with a Markov Random Field formulation leads...... to a slight improvement of segmentations....

  5. Learning from Multiple Collaborating Intelligent Tutors: An Agent-based Approach.

    Science.gov (United States)

    Solomos, Konstantinos; Avouris, Nikolaos

    1999-01-01

    Describes an open distributed multi-agent tutoring system (MATS) and discusses issues related to learning in such open environments. Topics include modeling a one student-many teachers approach in a computer-based learning context; distributed artificial intelligence; implementation issues; collaboration; and user interaction. (Author/LRW)

  6. A Genetic Algorithm Approach for Group Formation in Collaborative Learning Considering Multiple Student Characteristics

    Science.gov (United States)

    Moreno, Julian; Ovalle, Demetrio A.; Vicari, Rosa M.

    2012-01-01

    Considering that group formation is one of the key processes in collaborative learning, the aim of this paper is to propose a method based on a genetic algorithm approach for achieving inter-homogeneous and intra-heterogeneous groups. The main feature of such a method is that it allows for the consideration of as many student characteristics as…

  7. Fostering Creativity: A Multiple Intelligences Approach to Designing Learning in Undergraduate Fine Art

    Science.gov (United States)

    Clarke, Angela; Cripps, Peter

    2012-01-01

    Curriculum and pedagogy in undergraduate fine art can promote an approach to learning creativity that is more about being an artist than knowing about art. Lecturers can provide a road map for developing particular dispositions, in relation to student ideas and perceptions, to foster personalised creativity. This requires that lecturers have an…

  8. Identification of cardiac myofilament protein isoforms using multiple mass spectrometry based approaches

    NARCIS (Netherlands)

    Kooij, V.; Venkatraman, V.; Kirk, J.A.; Ubaida-Mohien, C.; Graham, D.R.; Faber, M.J.; Eyk, J.E. Van

    2014-01-01

    PURPOSE: The identification of protein isoforms in complex biological samples is challenging. We, therefore, used an MS approach to unambiguously identify cardiac myofilament protein isoforms based on the observation of a tryptic peptide consisting of a sequence unique to a particular isoform. EXPER

  9. MSblender: A probabilistic approach for integrating peptide identifications from multiple database search engines.

    Science.gov (United States)

    Kwon, Taejoon; Choi, Hyungwon; Vogel, Christine; Nesvizhskii, Alexey I; Marcotte, Edward M

    2011-07-01

    Shotgun proteomics using mass spectrometry is a powerful method for protein identification but suffers limited sensitivity in complex samples. Integrating peptide identifications from multiple database search engines is a promising strategy to increase the number of peptide identifications and reduce the volume of unassigned tandem mass spectra. Existing methods pool statistical significance scores such as p-values or posterior probabilities of peptide-spectrum matches (PSMs) from multiple search engines after high scoring peptides have been assigned to spectra, but these methods lack reliable control of identification error rates as data are integrated from different search engines. We developed a statistically coherent method for integrative analysis, termed MSblender. MSblender converts raw search scores from search engines into a probability score for every possible PSM and properly accounts for the correlation between search scores. The method reliably estimates false discovery rates and identifies more PSMs than any single search engine at the same false discovery rate. Increased identifications increment spectral counts for most proteins and allow quantification of proteins that would not have been quantified by individual search engines. We also demonstrate that enhanced quantification contributes to improve sensitivity in differential expression analyses.

  10. Graphene based multiple heterojunctions as an effective approach for high-performance gas sensing

    Science.gov (United States)

    Wu, Chia-Lin; Cheng, Ching-Cheng; Sun, Tzu-Min; Haider, Golam; Liou, Yi-Rou; Tan, Wei-Jyun; Chiang, Chia-Wei; Chen, Yang-Fang

    2016-09-01

    We develop graphene-based multiple heterojunctions to realize sensors with a very high sensitivity (current across the heterojunction. The charge induced by the absorbed molecules remains in the graphene layer without transferring into the underlying layer owing to the well-designed band alignment among the constituent materials, which results in ultra-fast and highly sensitive performance. Furthermore, we demonstrate that with different polarities of external bias, the graphene multiple-junction sensors can be used to selectively detect different gases. In addition to the suitable band alignment, the high performance of our device arises from the sandwich structure of top and bottom electrodes, which enables to exponentially enhance the current across the Schottky junction. Moreover, the large shift of the Fermi level of graphene induced by its inherent nature of low density of states also plays an important role. Compared with all published reports, our device possesses a much better performance. Particularly, the response time is three orders of magnitude faster than those of reported values, which can provide a critical step to advance graphene based gas sensors toward real world applications.

  11. A trace ratio maximization approach to multiple kernel-based dimensionality reduction.

    Science.gov (United States)

    Jiang, Wenhao; Chung, Fu-lai

    2014-01-01

    Most dimensionality reduction techniques are based on one metric or one kernel, hence it is necessary to select an appropriate kernel for kernel-based dimensionality reduction. Multiple kernel learning for dimensionality reduction (MKL-DR) has been recently proposed to learn a kernel from a set of base kernels which are seen as different descriptions of data. As MKL-DR does not involve regularization, it might be ill-posed under some conditions and consequently its applications are hindered. This paper proposes a multiple kernel learning framework for dimensionality reduction based on regularized trace ratio, termed as MKL-TR. Our method aims at learning a transformation into a space of lower dimension and a corresponding kernel from the given base kernels among which some may not be suitable for the given data. The solutions for the proposed framework can be found based on trace ratio maximization. The experimental results demonstrate its effectiveness in benchmark datasets, which include text, image and sound datasets, for supervised, unsupervised as well as semi-supervised settings.

  12. A Novel Approach for Ganglioside Structural Analysis Based on Electrospray Multiple-Stage Mass Spectrometry

    Science.gov (United States)

    Zamfir, Alina D.; Vukelić, Željka; Schneider, Andrea; Sisu, Eugen; Dinca, Nicolae; Ingendoh, Arnd

    2007-01-01

    A powerful method for detailed structural analysis based on electrospray ionization high-capacity ion-trap multiple-stage mass spectrometry (MS) is for the first time introduced in glycolipidomics. The method was optimized for accurate structural elucidation of human brain gangliosides and specifically applied to normal adult human hippocampus-associated structures. The multiple-stage MS experiments reported here allowed for a complete structural characterization of the oligosaccharide moiety of a GM1 ganglioside species. This was achieved by elucidating the sequence and identification of the GM1a structural isomer from the sialic acid attachment site at the neutral oligosaccharide chain. Moreover, the determination of the d18:1/18:0 sphingoid base/fatty acid composition of the ceramide moiety could be confirmed by this method. The novel protocol developed here proves high potential for rapid, reliable, and reproducible investigation of complex lipid-linked carbohydrates such as polysialylated gangliosides or species carrying some other groups that easily cleave off. PMID:17916791

  13. New approaches in the management of spasticity in multiple sclerosis patients: role of cannabinoids

    Directory of Open Access Journals (Sweden)

    Paul F Smith

    2010-02-01

    Full Text Available Paul F SmithDepartment of Pharmacology and Toxicology, School of Medical Sciences, University of Otago, Dunedin, New ZealandAbstract: Cannabinoids such as Cannabis-based medicinal extracts (CBMEs are increasingly being used in the treatment of spasticity associated with multiple sclerosis (MS. They have been shown to have a beneficial effect on spasticity; however, this evidence is largely based on subjective rating scales. Objective measurements using the Ashworth scale have tended to show no significant effect; however, the validity of this scale has been questioned. The available clinical trial data suggest that the adverse side effects associated with using CBMEs are generally mild, such as dry mouth, dizziness, somnolence, nausea and intoxication. However, most of these trials were run over a period of months and it is possible that other adverse side effects could develop with long-term use. There may be reason to be concerned about the use of therapeutic cannabinoids by adolescents, people predisposed to psychosis and pregnant women.Keywords: multiple sclerosis, spasticity, cannabinoids, Cannabis

  14. Object detection with DoG scale-space: a multiple kernel learning approach.

    Science.gov (United States)

    Nilufar, Sharmin; Ray, Nilanjan; Zhang, Hong

    2012-08-01

    Difference of Gaussians (DoG) scale-space for an image is a significant way to generate features for object detection and classification. While applying DoG scale-space features for object detection/classification, we face two inevitable issues: dealing with high dimensional data and selecting/weighting of proper scales. The scale selection process is mostly ad-hoc to date. In this paper, we propose a multiple kernel learning (MKL) method for both DoG scale selection/weighting and dealing with high dimensional scale-space data. We design a novel shift invariant kernel function for DoG scale-space. To select only the useful scales in the DoG scale-space, a novel framework of MKL is also proposed. We utilize a 1-norm support vector machine (SVM) in the MKL optimization problem for sparse weighting of scales from DoG scale-space. The optimized data-dependent kernel accommodates only a few scales that are most discriminatory according to the large margin principle. With a 2-norm SVM this learned kernel is applied to a challenging detection problem in oil sand mining: to detect large lumps in oil sand videos. We tested our method on several challenging oil sand data sets. Our method yields encouraging results on these difficult-to-process images and compares favorably against other popular multiple kernel methods.

  15. Optimal Control of Gene Regulatory Networks with Effectiveness of Multiple Drugs: A Boolean Network Approach

    Science.gov (United States)

    Kobayashi, Koichi; Hiraishi, Kunihiko

    2013-01-01

    Developing control theory of gene regulatory networks is one of the significant topics in the field of systems biology, and it is expected to apply the obtained results to gene therapy technologies in the future. In this paper, a control method using a Boolean network (BN) is studied. A BN is widely used as a model of gene regulatory networks, and gene expression is expressed by a binary value (0 or 1). In the control problem, we assume that the concentration level of a part of genes is arbitrarily determined as the control input. However, there are cases that no gene satisfying this assumption exists, and it is important to consider structural control via external stimuli. Furthermore, these controls are realized by multiple drugs, and it is also important to consider multiple effects such as duration of effect and side effects. In this paper, we propose a BN model with two types of the control inputs and an optimal control method with duration of drug effectiveness. First, a BN model and duration of drug effectiveness are discussed. Next, the optimal control problem is formulated and is reduced to an integer linear programming problem. Finally, numerical simulations are shown. PMID:24058904

  16. A Fault-Tolerant Multiple Sensor Fusion Approach Applied to UAV Attitude Estimation

    Directory of Open Access Journals (Sweden)

    Yu Gu

    2016-01-01

    Full Text Available A novel sensor fusion design framework is presented with the objective of improving the overall multisensor measurement system performance and achieving graceful degradation following individual sensor failures. The Unscented Information Filter (UIF is used to provide a useful tool for combining information from multiple sources. A two-step off-line and on-line calibration procedure refines sensor error models and improves the measurement performance. A Fault Detection and Identification (FDI scheme crosschecks sensor measurements and simultaneously monitors sensor biases. Low-quality or faulty sensor readings are then rejected from the final sensor fusion process. The attitude estimation problem is used as a case study for the multiple sensor fusion algorithm design, with information provided by a set of low-cost rate gyroscopes, accelerometers, magnetometers, and a single-frequency GPS receiver’s position and velocity solution. Flight data collected with an Unmanned Aerial Vehicle (UAV research test bed verifies the sensor fusion, adaptation, and fault-tolerance capabilities of the designed sensor fusion algorithm.

  17. Practical Approaches to the Use of Lenalidomide in Multiple Myeloma: A Canadian Consensus

    Directory of Open Access Journals (Sweden)

    Donna Reece

    2012-01-01

    Full Text Available In Canada, lenalidomide combined with dexamethasone (Len/Dex is approved for use in relapsed or refractory multiple myeloma (RRMM. Our expert panel sought to provide an up-to-date practical guide on the use of lenalidomide in the managing RRMM within the Canadian clinical setting, including management of common adverse events (AEs. The panel concluded that safe, effective administration of Len/Dex treatment involves the following steps: (1 lenalidomide dose adjustment based on creatinine clearance and the extent of neutropenia or thrombocytopenia, (2 dexamethasone administered at 20–40 mg/week, and (3 continuation of treatment until disease progression or until toxicity persists despite dose reduction. Based on available evidence, the following precautions should reduce the risk of common Len/Dex AEs: (1 all patients treated with Len/Dex should receive thromboprophylaxis, (2 erythropoiesis-stimulating agents (ESAs should be used cautiously, and (3 females of child-bearing potential and males in contact with such females must use multiple contraception methods. Finally, while Len/Dex can be administered irrespective of prior therapy and in all prognostic subsets, patients with chromosomal deletion 17(p13 have less favorable outcomes with all treatments, including Len/Dex. New directions for the use of lenalidomide in RRMM are also considered.

  18. Performance and physiological responses to repeated-sprint exercise: a novel multiple-set approach.

    Science.gov (United States)

    Serpiello, Fabio R; McKenna, Michael J; Stepto, Nigel K; Bishop, David J; Aughey, Robert J

    2011-04-01

    We investigated the acute and chronic responses to multiple sets of repeated-sprint exercise (RSE), focusing on changes in acceleration, intermittent running capacity and physiological responses. Ten healthy young adults (7 males, 3 females) performed an incremental test, a Yo-Yo intermittent recovery test level1 (Yo-Yo IR1), and one session of RSE. RSE comprised three sets of 5 × 4-s maximal sprints on a non-motorised treadmill, with 20 s of passive recovery between repetitions and 4.5 min of passive recovery between sets. After ten repeated-sprint training sessions, participants repeated all tests. During RSE, performance was determined by measuring acceleration, mean and peak power/velocity. Recovery heart rate (HR), HR variability, and finger-tip capillary lactate concentration ([Lac(-)]) were measured. Performance progressively decreased across the three sets of RSE, with the indices of repeated-sprint ability being impaired to a different extent before and after training. Training induced a significant increase (p RSE. There were strong correlations between Yo-Yo IR1 performance and indices of RSE performance, especially acceleration post-training (r = 0.88, p = 0.004). Repeated-sprint training, comprising only 10 min of exercise overall, effectively improved performance during multiple-set RSE. This exercise model better reflects team-sport activities than single-set RSE. The rapid training-induced improvement in acceleration, quantified here for the first time, has wide applications for professional and recreational sport activities.

  19. A Hybrid One-Way ANOVA Approach for the Robust and Efficient Estimation of Differential Gene Expression with Multiple Patterns.

    Directory of Open Access Journals (Sweden)

    Mohammad Manir Hossain Mollah

    Full Text Available Identifying genes that are differentially expressed (DE between two or more conditions with multiple patterns of expression is one of the primary objectives of gene expression data analysis. Several statistical approaches, including one-way analysis of variance (ANOVA, are used to identify DE genes. However, most of these methods provide misleading results for two or more conditions with multiple patterns of expression in the presence of outlying genes. In this paper, an attempt is made to develop a hybrid one-way ANOVA approach that unifies the robustness and efficiency of estimation using the minimum β-divergence method to overcome some problems that arise in the existing robust methods for both small- and large-sample cases with multiple patterns of expression.The proposed method relies on a β-weight function, which produces values between 0 and 1. The β-weight function with β = 0.2 is used as a measure of outlier detection. It assigns smaller weights (≥ 0 to outlying expressions and larger weights (≤ 1 to typical expressions. The distribution of the β-weights is used to calculate the cut-off point, which is compared to the observed β-weight of an expression to determine whether that gene expression is an outlier. This weight function plays a key role in unifying the robustness and efficiency of estimation in one-way ANOVA.Analyses of simulated gene expression profiles revealed that all eight methods (ANOVA, SAM, LIMMA, EBarrays, eLNN, KW, robust BetaEB and proposed perform almost identically for m = 2 conditions in the absence of outliers. However, the robust BetaEB method and the proposed method exhibited considerably better performance than the other six methods in the presence of outliers. In this case, the BetaEB method exhibited slightly better performance than the proposed method for the small-sample cases, but the the proposed method exhibited much better performance than the BetaEB method for both the small- and large

  20. Defect Modes in Multiple-Constituent One-Dimensional Photonic Crystals Examined by an Analytic Bloch-Mode Approach

    Institute of Scientific and Technical Information of China (English)

    SANG Hong-Yi; LI Zhi-Yuan; GU Ben-Yuan

    2005-01-01

    @@ Defect modes in one-dimensional photonic crystals (PCs) can be readily detected from the solution of the transmission spectra via the standard transfer-matrix method. We adopt an analytic Bloch-mode approach to examine this problem in terms of eigenmode solutions and investigate the dispersion behaviour of localized defect modes supported by a defect layer sandwiched within two symmetric semi-infinite PCs that are made from multiple constituents. The results show that the number of defect modes grows when the dielectric constant and width of the defect layer increase.

  1. Deterministic light focusing in space and time through multiple scattering media with a Time-Resolved Transmission Matrix approach

    CERN Document Server

    Mounaix, Mickael; Gigan, Sylvain

    2016-01-01

    We report a method to characterize the propagation of an ultrashort pulse of light through a multiple scattering medium by measuring its time-resolved transmission matrix. This method is based on the use of a spatial light modulator together with a coherent time-gated detection of the transmitted speckle field. Using this matrix, we demonstrate the focusing of the scattered pulse at any arbitrary position in space and time after the medium. Our approach opens new perspectives for both fundamental studies and applications in imaging and coherent control in disordered media.

  2. Estrategias de resolución del PASAT en pacientes con Esclerosis Múltiple y viabilidad de una versión corta del test

    Directory of Open Access Journals (Sweden)

    Evangelina Cores

    2011-12-01

    Full Text Available El PASAT es una herramienta de evaluación neuropsicológica frecuentemente implementada en la clínica de pacientes con Esclerosis Múltiple (EM. Este estudio se propone analizar las estrategias de resolución del PASAT y establecer la sensibilidad de una versión corta de 30 ítems y otra de 20 ítems en pacientes con EM. Metodología: Se administró una batería neuropsicológica a 38 pacientes con EM curso recaídas y remisiones y 32 voluntarios sanos de similar edad y escolaridad. Resultados: El PASAT-3 diferenció significativamente el grupo EM del grupo control en el total de respuestas correctas (Z = -2,714, p = ,007, chunkings (Z = -2,478, p = ,013 y díadas (Z = -2,647, p = ,008. El efecto de tamaño para todos los puntajes fue moderado. Respecto de la versión de 60 ítems, la versión de 30 ítems demostró una sensibilidad del 85%, con solo dos falsos negativos y la versión de 20 ítems logró una sensibilidad del 57%. Discusión: La puntuación de chunks y díadas es útil para medir las estrategias de resolución de la tarea. La versión corta del test de 30 ítems es una medida apropiada para su uso en la clínica neuropsicológica.

  3. Esclerosis lateral amiotrófica: ¿es el astrocito la célula primariamente dañada?

    Directory of Open Access Journals (Sweden)

    Roberto E. Sica

    2013-12-01

    Full Text Available La esclerosis lateral amiotrófica (ELA es considerada una enfermedad primaria de las motoneuronas. Ninguno de los procesos que conforman su patogenia ha probado ser su causa. Tampoco pudo demostrarse que factores ambientales la originen. Las neuronas mueren por apoptosis, hecho que abre la posibilidad de que ello sea debido a cambios en su ambiente, sin que constituyan el blanco directo de la noxa que ocasiona la enfermedad. El examen del medio que circunda a las motoneuronas encuentra a los astrocitos como responsables de su bienestar. Éstos son células plásticas, adaptan su función al tipo de neurona con la que se relacionan, cada población astrocitaria es única; si fuera afectada, las neuronas que le son dependientes padecerían. En el caso de las motoneuronas, esta circunstancia llevaría a la alteración de la producción astrocitaria de neurotransmisores y transportadores y a la carencia de nutrientes y factores tróficos que le suministran. Para explicar por qué en la ELA los síntomas se trasladan de un grupo muscular al vecino, observación correlacionada con lo que ocurre en las neuronas motoras corticales y espinales, la hipótesis aquí sostenida sugiere que el factor causante migra de un astrocito a otro, lesionándolos y privando a las motoneuronas del cuidado que le prodigan. También propone que una proteína del astrocito se pliega defectuosamente, transformándose en infecciosa e induciendo el plegamiento errado de sus similares normales, trasladándose entre los astrocitos protoplásmicos y a los astrocitos fibrosos que rodean la vía piramidal, utilizando para ello las sinapsis de hendidura.

  4. DEWA: A Multiaspect Approach for Multiple Face Detection in Complex Scene Digital Image

    Directory of Open Access Journals (Sweden)

    Setiawan Hadi

    2013-09-01

    Full Text Available A new approach for detecting faces in a digital image with unconstrained background has been developed. The approach is composed of three phases: segmentation phase, filtering phase and localization phase. In the segmentation phase, we utilized both training and non-training methods, which are implemented in user selectable color space. In the filtering phase, Minkowski addition-based objects removal has been used for image cleaning. In the last phase, an image processing method and a data mining method are employed for grouping and localizing objects, combined with geometric-based image analysis. Several experiments have been conducted using our special face database that consists of simple objects and complex objects. The experiment results demonstrated that the detection accuracy is around 90% and the detection speed is less than 1 second in average.

  5. DEWA: A Multiaspect Approach for Multiple Face Detection in Complex Scene Digital Image

    Directory of Open Access Journals (Sweden)

    Setiawan Hadi

    2007-05-01

    Full Text Available A new approach for detecting faces in a digital image with unconstrained background has been developed. The approach is composed of three phases: segmentation phase, filtering phase and localization phase. In the segmentation phase, we utilized both training and non-training methods, which are implemented in user selectable color space. In the filtering phase, Minkowski addition-based objects removal has been used for image cleaning. In the last phase, an image processing method and a data mining method are employed for grouping and localizing objects, combined with geometric-based image analysis. Several experiments have been conducted using our special face database that consists of simple objects and complex objects. The experiment results demonstrated that the detection accuracy is around 90% and the detection speed is less than 1 second in average.

  6. Monte Carlo wave packet approach to dissociative multiple ionization in diatomic molecules

    DEFF Research Database (Denmark)

    Leth, Henriette Astrup; Madsen, Lars Bojer; Mølmer, Klaus

    2010-01-01

    A detailed description of the Monte Carlo wave packet technique applied to dissociative multiple ionization of diatomic molecules in short intense laser pulses is presented. The Monte Carlo wave packet technique relies on the Born-Oppenheimer separation of electronic and nuclear dynamics...... and provides a consistent theoretical framework for treating simultaneously both ionization and dissociation. By simulating the detection of continuum electrons and collapsing the system onto either the neutral, singly ionized or doubly ionized states in every time step the nuclear dynamics can be solved....... The computational effort is restricted and the model is applicable to any molecular system where electronic Born-Oppenheimer curves, dipole moment functions, and ionization rates as a function of nuclear coordinates can be determined....

  7. An Optical / Wireless Integrated Approach to provide Multiple Gateways in Wireless Mesh Networks

    Directory of Open Access Journals (Sweden)

    Muhammad Raheel

    2012-03-01

    Full Text Available Wireless Mesh Network is an application technology different from the traditional peer-to-peer wireless bridge; it provides the multi-hop and multi-path connection to form a wireless environment of MESH framework so that the occurrence of single point failure can be prevented.WMNs are to provide high bandwidth broadband service to a large community of users through the use Internet Gateways which acts as a central point of internet attachment for the mesh routers, it is likely to be a potential bottleneck because of its limited wireless link capacity and security considerations of the Internet Gateways .By integrating Optical fiber network technologies with wireless mesh network we can achieve the Security and increase the capacity of the network, in this paper we define integration models with multiple gateways in the access network, which increases the capacity of wireless networks, increase security in network gateways, and decreases access point complexity through centralized management.

  8. Power-Performance Tradeoffs in Wide Dynamic Range Image Sensors with Multiple Reset Approach

    Directory of Open Access Journals (Sweden)

    Arthur Spivak

    2011-03-01

    Full Text Available A variety of solutions for widening the dynamic range (DR of CMOS image sensors have been proposed throughout the years. These solutions can be categorized into different groups according to the principle used for DR widening. One of the methods, which is based on autonomous control over the integration time, was implemented by our group. We proposed the multiple resets algorithm, which was successfully implemented in three generations of WDR image sensors. While achieving the same goal of widening the DR of the sensor, each of the implemented imagers had a different architecture, and therefore presented different performance and power figures. This paper reviews designs of the aforementioned sensors and presents a comprehensive analysis of their power consumption. Power-performance tradeoffs are also discussed. Advantages and disadvantages of each sensor are presented.

  9. Prediction of peptide conformation by multicanonical algorithm a new approach to the multiple-minima problem

    CERN Document Server

    Hansmann, Uwe H E; Hansmann, Ulrich H.E.; Okamoto, Yuko

    1993-01-01

    We apply a recently developed method, multicanonical algorithm, to the problem of tertiary structure prediction of peptides and proteins. As a simple example to test the effectiveness of the algorithm, Met-enkephalin is studied and the ergodicity problem, or multiple-minima problem, is shown to be overcome by this algorithm. The lowest-energy conformation obtained agrees with that determined by other efficient methods such as Monte Carlo simulated annealing. The superiority of the present method to simulated annealing lies in the fact that the relationship to the canonical ensemble remains exactly controlled. Once the multicanonical parameters are determined, only one simulation run is necessary to obtain the lowest-energy conformation and furthermore the results of this one run can be used to calculate various thermodynamic quantities at any temperature. The latter point is demonstrated by the calculation of the average potential energy and specific heat as functions of temperature.

  10. A Bayesian Game-Theoretic Approach for Distributed Resource Allocation in Fading Multiple Access Channels

    Directory of Open Access Journals (Sweden)

    Gaoning He

    2010-01-01

    Full Text Available A Bayesian game-theoretic model is developed to design and analyze the resource allocation problem in K-user fading multiple access channels (MACs, where the users are assumed to selfishly maximize their average achievable rates with incomplete information about the fading channel gains. In such a game-theoretic study, the central question is whether a Bayesian equilibrium exists, and if so, whether the network operates efficiently at the equilibrium point. We prove that there exists exactly one Bayesian equilibrium in our game. Furthermore, we study the network sum-rate maximization problem by assuming that the users coordinate according to a symmetric strategy profile. This result also serves as an upper bound for the Bayesian equilibrium. Finally, simulation results are provided to show the network efficiency at the unique Bayesian equilibrium and to compare it with other strategies.

  11. Multiple microscopic approaches demonstrate linkage between chromoplast architecture and carotenoid composition in diverse Capsicum annuum fruit.

    Science.gov (United States)

    Kilcrease, James; Collins, Aaron M; Richins, Richard D; Timlin, Jerilyn A; O'Connell, Mary A

    2013-12-01

    Increased accumulation of specific carotenoids in plastids through plant breeding or genetic engineering requires an understanding of the limitations that storage sites for these compounds may impose on that accumulation. Here, using Capsicum annuum L. fruit, we demonstrate directly the unique sub-organellar accumulation sites of specific carotenoids using live cell hyperspectral confocal Raman microscopy. Further, we show that chromoplasts from specific cultivars vary in shape and size, and these structural variations are associated with carotenoid compositional differences. Live-cell imaging utilizing laser scanning confocal (LSCM) and confocal Raman microscopy, as well as fixed tissue imaging by scanning and transmission electron microscopy (SEM and TEM), all demonstrated morphological differences with high concordance for the measurements across the multiple imaging modalities. These results reveal additional opportunities for genetic controls on fruit color and carotenoid-based phenotypes.

  12. Pinning Synchronization of Directed Networks With Switching Topologies: A Multiple Lyapunov Functions Approach.

    Science.gov (United States)

    Wen, Guanghui; Yu, Wenwu; Hu, Guoqiang; Cao, Jinde; Yu, Xinghuo

    2015-12-01

    This paper studies the global pinning synchronization problem for a class of complex networks with switching directed topologies. The common assumption in the existing related literature that each possible network topology contains a directed spanning tree is removed in this paper. Using tools from M -matrix theory and stability analysis of the switched nonlinear systems, a new kind of network topology-dependent multiple Lyapunov functions is proposed for analyzing the synchronization behavior of the whole network. It is theoretically shown that the global pinning synchronization in switched complex networks can be ensured if some nodes are appropriately pinned and the coupling is carefully selected. Interesting issues of how many and which nodes should be pinned for possibly realizing global synchronization are further addressed. Finally, some numerical simulations on coupled neural networks are provided to verify the theoretical results.

  13. A probabilistic graphical model approach in 30 m land cover mapping with multiple data sources

    OpenAIRE

    Wang, Jie; Ji, Luyan; Huang, Xiaomeng; Fu, Haohuan; Xu, Shiming; Li, Congcong

    2016-01-01

    There is a trend to acquire high accuracy land-cover maps using multi-source classification methods, most of which are based on data fusion, especially pixel- or feature-level fusions. A probabilistic graphical model (PGM) approach is proposed in this research for 30 m resolution land-cover mapping with multi-temporal Landsat and MODerate Resolution Imaging Spectroradiometer (MODIS) data. Independent classifiers were applied to two single-date Landsat 8 scenes and the MODIS time-series data, ...

  14. Biased Competition in Visual Processing Hierarchies: A Learning Approach Using Multiple Cues.

    Science.gov (United States)

    Gepperth, Alexander R T; Rebhan, Sven; Hasler, Stephan; Fritsch, Jannik

    2011-03-01

    In this contribution, we present a large-scale hierarchical system for object detection fusing bottom-up (signal-driven) processing results with top-down (model or task-driven) attentional modulation. Specifically, we focus on the question of how the autonomous learning of invariant models can be embedded into a performing system and how such models can be used to define object-specific attentional modulation signals. Our system implements bi-directional data flow in a processing hierarchy. The bottom-up data flow proceeds from a preprocessing level to the hypothesis level where object hypotheses created by exhaustive object detection algorithms are represented in a roughly retinotopic way. A competitive selection mechanism is used to determine the most confident hypotheses, which are used on the system level to train multimodal models that link object identity to invariant hypothesis properties. The top-down data flow originates at the system level, where the trained multimodal models are used to obtain space- and feature-based attentional modulation signals, providing biases for the competitive selection process at the hypothesis level. This results in object-specific hypothesis facilitation/suppression in certain image regions which we show to be applicable to different object detection mechanisms. In order to demonstrate the benefits of this approach, we apply the system to the detection of cars in a variety of challenging traffic videos. Evaluating our approach on a publicly available dataset containing approximately 3,500 annotated video images from more than 1 h of driving, we can show strong increases in performance and generalization when compared to object detection in isolation. Furthermore, we compare our results to a late hypothesis rejection approach, showing that early coupling of top-down and bottom-up information is a favorable approach especially when processing resources are constrained.

  15. Mass functions assessment: case of multiple hypothesis for the evidential approach

    Science.gov (United States)

    Menard, Michel; Zahzah, El-hadi; Shahin, Ahmad

    1996-12-01

    The purpose of this paper is to define the mass functions for a set of multiple mixed hypothesis in an context of Dempster/Shafer (DS) theory which offers an interesting tool to combine data providing from heterogeneous sources more or less reliable by managing imprecision and uncertainty. This is particularly important when dealing with multi-modality imaging (satellite image), where the fusion of information increases the global knowledge about the phenomenon while decreasing the imprecision and uncertainty about it. This theory also enables us to assign masses to 2D elements (D: decision space) rather than to D elements as in probabilistic theory. The DS has been used in many applications in the field of image analysis, but without its all powerful. When using with only simple hypothesis (an object belongs to only one class), the theory falls in the probabilistic case, which is considered as a particular case. Bloch and Barnett attempt to use double hypothesis but their method still remains particular and restrictive. We propose in this paper a method to extract for a class the consonance and dissonance degrees among several classifiers (methods), and the integration of these terms to initialize the mass functions with multiple mixed hypothesis in order to use the orthogonal Dempster/Shafer Rule. The problem must be viewed from multiclass, multi-sources (images) and multi- point of view (methods or classifiers used) context. We first show how our method works with 1 -- image, 2 -- classifiers, and 2 -- hypothesis and then generalize for P - - images, K -- sources and 2D -- hypothesis.

  16. Hybrid approaches for multiple-species stochastic reaction-diffusion models.

    KAUST Repository

    Spill, Fabian

    2015-10-01

    Reaction-diffusion models are used to describe systems in fields as diverse as physics, chemistry, ecology and biology. The fundamental quantities in such models are individual entities such as atoms and molecules, bacteria, cells or animals, which move and/or react in a stochastic manner. If the number of entities is large, accounting for each individual is inefficient, and often partial differential equation (PDE) models are used in which the stochastic behaviour of individuals is replaced by a description of the averaged, or mean behaviour of the system. In some situations the number of individuals is large in certain regions and small in others. In such cases, a stochastic model may be inefficient in one region, and a PDE model inaccurate in another. To overcome this problem, we develop a scheme which couples a stochastic reaction-diffusion system in one part of the domain with its mean field analogue, i.e. a discretised PDE model, in the other part of the domain. The interface in between the two domains occupies exactly one lattice site and is chosen such that the mean field description is still accurate there. In this way errors due to the flux between the domains are small. Our scheme can account for multiple dynamic interfaces separating multiple stochastic and deterministic domains, and the coupling between the domains conserves the total number of particles. The method preserves stochastic features such as extinction not observable in the mean field description, and is significantly faster to simulate on a computer than the pure stochastic model.

  17. [Multiplicity of syndromes associating manic and depressive symptoms: the need for a dimensional approach].

    Science.gov (United States)

    Henry, C; M'baïlara, K; Desage, A; Antoniol, B

    2006-01-01

    The heterogeneity of mood states in bipolar disorders leads to some confusion in diagnostic and therapeutic strategies. Apart from the classical syndromes characterizing euphoric mania and melancholic depression, recent literature has pointed to alternative mood states associating both manic and depressive symptoms. This resulted in the definition of various syndromes including mixed states, dysphoric mania, agitated depression and more recently the depressive mixed state. This consequently raises the question of the best therapeutic strategies. As the boundaries between the various states associating both depressive and manic symptoms have yet to be clarified, there is a need to further discuss whether dimensional rather than categorical approaches could help to further refine their definitions and define the best therapeutic strategies. As stated by Kraepelin, mood episodes in manic-depressive illness were defined according to three dimensions: mood, cognitive processes, and motor and motivational drive. Cognitive and motor processes were regarded as quantitative items whose alterations may correspond to either an increase or a decrease. The current definitions are far from this dimensional approach. Thus, the current diagnostic criteria make it difficult to define mixed states. Such poorly convincing diagnostic criteria may account for the description of many other states exhibiting both manic and depressive symptoms. A dimensional approach could be useful to define mood states in bipolar disorders. These dimensions should progressive, from inhibition to excitation. Because tonality affects is not a dimension, the emotional reactivity (hyper-reactivity versus hypo-reactivity) represents an additional dimension that would help characterize these states better.

  18. A Runway Incursion Detection Approach Based on Multiple Protected Area and Flight Status Machine for A-SMGCS

    Directory of Open Access Journals (Sweden)

    Li Jing

    2016-01-01

    Full Text Available A-SMGCS is a modular system defined in the ICAO (International Civil Aviation Organization Manual on Advanced Surface Movement Guidance and Control System (A-SMGCS .One of A-SMGCS goals is to provide enhanced safety and protection of the runway. This paper presents a novel runway incursion detection approach for A-SMGCS, in which a multiple protected area is proposed to decrease complexity of pre-treatment for incursion judgment, and a flight status machine is designed to specify the transitions of one flight from one target status to another. Additionally, an HMI (Human Machine Interface independently developed by the Second Research Institute of CAAC (Civil Aviation Administration of China was designed in order to validate the runway incursion detection approach, the result shows that the algorithm has the potential to significantly improve runway safety by early detection and alerting of runway incursions.

  19. Multiple Feature Fusion Based on Co-Training Approach and Time Regularization for Place Classification in Wearable Video

    Directory of Open Access Journals (Sweden)

    Vladislavs Dovgalecs

    2013-01-01

    Full Text Available The analysis of video acquired with a wearable camera is a challenge that multimedia community is facing with the proliferation of such sensors in various applications. In this paper, we focus on the problem of automatic visual place recognition in a weakly constrained environment, targeting the indexing of video streams by topological place recognition. We propose to combine several machine learning approaches in a time regularized framework for image-based place recognition indoors. The framework combines the power of multiple visual cues and integrates the temporal continuity information of video. We extend it with computationally efficient semisupervised method leveraging unlabeled video sequences for an improved indexing performance. The proposed approach was applied on challenging video corpora. Experiments on a public and a real-world video sequence databases show the gain brought by the different stages of the method.

  20. Collision-free Multiple Unmanned Combat Aerial Vehicles Cooperative Trajectory Planning for Time-critical Missions using Differential Flatness Approach

    Directory of Open Access Journals (Sweden)

    Xueqiang Gu

    2014-01-01

    Full Text Available This paper investigates the cooperative trajectory planning for multiple unmanned combat aerial vehicles in performing autonomous cooperative air-to-ground target attack missions. Firstly, the collision-free cooperative trajectory planning problem for time-critical missions is formulated as a cooperative trajectory optimal control problem (CTP-OCP, which is based on an approximate allowable attack region model, several constraints model, and a multi-criteria objective function. Next, a planning algorithm based on the differential flatness, B-spline curves and nonlinear programming is designed to solve the CTP-OCP. In particular, the notion of the virtual time is introduced to deal with the temporal constraints. Finally, the proposed approach is validated by two typical scenarios and the simulation results show the feasibility and effectiveness of the proposed planning approach.Defence Science Journal, Vol. 64, No. 1, January 2014, DOI:10.14429/dsj.64.2999

  1. Simulating mesoscale coastal evolution for decadal coastal management: A new framework integrating multiple, complementary modelling approaches

    Science.gov (United States)

    van Maanen, Barend; Nicholls, Robert J.; French, Jon R.; Barkwith, Andrew; Bonaldo, Davide; Burningham, Helene; Brad Murray, A.; Payo, Andres; Sutherland, James; Thornhill, Gillian; Townend, Ian H.; van der Wegen, Mick; Walkden, Mike J. A.

    2016-03-01

    Coastal and shoreline management increasingly needs to consider morphological change occurring at decadal to centennial timescales, especially that related to climate change and sea-level rise. This requires the development of morphological models operating at a mesoscale, defined by time and length scales of the order 101 to 102 years and 101 to 102 km. So-called 'reduced complexity' models that represent critical processes at scales not much smaller than the primary scale of interest, and are regulated by capturing the critical feedbacks that govern landform behaviour, are proving effective as a means of exploring emergent coastal behaviour at a landscape scale. Such models tend to be computationally efficient and are thus easily applied within a probabilistic framework. At the same time, reductionist models, built upon a more detailed description of hydrodynamic and sediment transport processes, are capable of application at increasingly broad spatial and temporal scales. More qualitative modelling approaches are also emerging that can guide the development and deployment of quantitative models, and these can be supplemented by varied data-driven modelling approaches that can achieve new explanatory insights from observational datasets. Such disparate approaches have hitherto been pursued largely in isolation by mutually exclusive modelling communities. Brought together, they have the potential to facilitate a step change in our ability to simulate the evolution of coastal morphology at scales that are most relevant to managing erosion and flood risk. Here, we advocate and outline a new integrated modelling framework that deploys coupled mesoscale reduced complexity models, reductionist coastal area models, data-driven approaches, and qualitative conceptual models. Integration of these heterogeneous approaches gives rise to model compositions that can potentially resolve decadal- to centennial-scale behaviour of diverse coupled open coast, estuary and inner

  2. A Generic Multiple Reaction Monitoring Based Approach for Plant Flavonoids Profiling Using a Triple Quadrupole Linear Ion Trap Mass Spectrometry

    Science.gov (United States)

    Yan, Zhixiang; Lin, Ge; Ye, Yang; Wang, Yitao; Yan, Ru

    2014-06-01

    Flavonoids are one of the largest classes of plant secondary metabolites serving a variety of functions in plants and associating with a number of health benefits for humans. Typically, they are co-identified with many other secondary metabolites using untargeted metabolomics. The limited data quality of untargeted workflow calls for a shift from the breadth-first to the depth-first screening strategy when a specific biosynthetic pathway is focused on. Here we introduce a generic multiple reaction monitoring (MRM)-based approach for flavonoids profiling in plants using a hybrid triple quadrupole linear ion trap (QTrap) mass spectrometer. The approach includes four steps: (1) preliminary profiling of major aglycones by multiple ion monitoring triggered enhanced product ion scan (MIM-EPI); (2) glycones profiling by precursor ion triggered EPI scan (PI-EPI) of major aglycones; (3) comprehensive aglycones profiling by combining MIM-EPI and neutral loss triggered EPI scan (NL-EPI) of major glycone; (4) in-depth flavonoids profiling by MRM-EPI with elaborated MRM transitions. Particularly, incorporation of the NH3 loss and sugar elimination proved to be very informative and confirmative for flavonoids screening. This approach was applied for profiling flavonoids in Astragali radix ( Huangqi), a famous herb widely used for medicinal and nutritional purposes in China. In total, 421 flavonoids were tentatively characterized, among which less than 40 have been previously reported in this medicinal plant. This MRM-based approach provides versatility and sensitivity that required for flavonoids profiling in plants and serves as a useful tool for plant metabolomics.

  3. Digital adaptive coronagraphy using SLMs: promising prospects of a novel approach, including high-contrast imaging of multiple stars systems

    Science.gov (United States)

    Kühn, Jonas; Patapis, Polychronis

    2016-07-01

    We introduce a new technological framework for high-contrast coronagraphy, namely digital adaptive coronagraphy (DAC) using spatial light modulators (SLMs), taking advantage of recent advances in this technology. We present proof-of-principle experimental results in the visible, using a transmissive twisted nematic liquid crystal SLM display to show that SLMs can be successfully implemented as focal-plane phase-mask coronagraphs (4QPM, 8OPM,...), and that the technology is essentially in place to address realistic instrumental configurations. We explore a specific application where SLM-based adaptive coronagraphy might be particularly competitive, which is direct imaging of multiple stars systems, by simultaneously nulling multiple point sources in the field. Using a simple approach to compute a brightness-weighted synthetized coronagraphic phase map, we show that in the case of binaries the contrast gain over using a regular phase map can exceed 4 stellar magnitudes for a 1:1 binaries down to separation as close as 1 λ/D. Thanks to video-rate update frequency of the SLM, the technique is in principle compatible with sky rotation in the case of altitude-azimuth telescope mounts, and can address multiple target configurations with no actual mechanical or hardware change.

  4. A study on the regulatory approach of KNGR multiple failure events

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Keun Sun; Kweon, Y. C.; Kang, H. J.; Lee, S. J.; Cheong, D. Y.; Lee, Y. S.; Lee, M. K. [Sunmoon Univ., Asan (Korea, Republic of); Jeong, Ji Hwan [Baekseok College of Cultural studies, Cheonan (Korea, Republic of)

    2001-01-15

    This project is to provide the regulatory direction of containment bypass during multiple steam generator tube failure issue for the Korean Next Generation Reactors, which is a part of major technical issues resulted from the safety regulation R and D on the KNGR. The outstanding results are as follows : the Multiple Steam Generator Tube Repture(MSGTR) event has never been occurred in the history of commercial nuclear reactor operation but single Steam Generator Tube Rupture(SGTR) event is reported to occur every two years. A probabilistic safety analysis study on MSGTR event, however, show its probability of occurrence is to be the same order as the design basis accidents such as LACA. In this regard, the ability of NPPs to cope with MSGTR event is required. Some requirements on initial and boundary conditions are suggested to be used in the analyses of NPPs during MSGTR events. The items that should be considered in establishing regulatory requirements are summarized as follows : the analyses of MSGTR events should be performed by a best-estimate method with normal full power conditions except initial reactor power of 102%, all safety- and non-safety grade systems and components are assumed to be available only in automatic mode, tube ruptures are assumed to occur at the steam generator which is in the loop connected with a pressurizer, guillotine-type tube raptures are assumed near tube sheet on hot-leg side, the results of 1-5 tube ruptures should be compared, an appropriate break flow model should be used and critical flow model can be compared, an appropriate break flow model should be used and critical flow model can be used if needed, operator response time should be based on ANSI/ANS-51.1-1983 and ANSI/ANS-58.8-1984, acceptance criteria should be stated in terms of MSSV lift time as well as radiological consequences. It is recommended that some analyses should be carried out in order to figure out the effects of tube rupture modelling methods. A single

  5. In vivo imaging of system xc- as a novel approach to monitor multiple sclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Abraham; Szczupak, Boguslaw; Arrieta, Ander [CIC biomaGUNE, Molecular Imaging Unit, San Sebastian (Spain); Vazquez-Villoldo, Nuria; Soria, Federico N.; Domercq, Maria; Matute, Carlos [University of the Basque Country, Department of Neurosciences, Leioa (Spain); UPV/EHU, Achucarro Basque Center for Neuroscience, Zamudio (Spain); Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Leioa (Spain); Gomez-Vallejo, Vanessa; Llop, Jordi [CIC biomaGUNE, Molecular Imaging Unit, San Sebastian (Spain); CIC biomaGUNE, Radiochemistry and Nuclear Imaging, San Sebastian (Spain); Padro, Daniel; Plaza-Garcia, Sandra; Reese, Torsten [CIC biomaGUNE, Molecular Imaging Unit, San Sebastian (Spain); CIC biomaGUNE, Magnetic Resonance Imaging, San Sebastian (Spain)

    2016-06-15

    Glutamate excitotoxicity contributes to oligodendroglial and axonal damage in multiple sclerosis pathology. Extracellular glutamate concentration in the brain is controlled by cystine/glutamate antiporter (system xc-), a membrane antiporter that imports cystine and releases glutamate. Despite this, the system xc{sup -} activity and its connection to the inflammatory reaction in multiple sclerosis (MS) is largely unknown. Longitudinal in vivo magnetic resonance (MRI) and positron emission tomography (PET) imaging studies with 2-[{sup 18}F]Fluoro-2-deoxy-D-glucose ([{sup 18}F]FDG), [{sup 11}C]-(R)-1-(2-chlorophenyl)-N-methyl-N-1(1-methylpropyl) -3-isoquinolinecarbox amide ([{sup 11}C]PK11195) and (4S)-4-(3-{sup 18}F-fluoropropyl)-L-glutamate ([{sup 18}F]FSPG) were carried out during the course of experimental autoimmune encephalomyelitis (EAE) induction in rats. [{sup 18}F]FSPG showed a significant increase of system xc{sup -} function in the lumbar section of the spinal cord at 14 days post immunization (dpi) that stands in agreement with the neurological symptoms and ventricle edema formation at this time point. Likewise, [{sup 18}F]FDG did not show significant changes in glucose metabolism throughout central nervous system and [{sup 11}C]PK11195 evidenced a significant increase of microglial/macrophage activation in spinal cord and cerebellum 2 weeks after EAE induction. Therefore, [{sup 18}F]FSPG showed a major capacity to discriminate regions of the central nervous system affected by the MS in comparison to [{sup 18}F]FDG and [{sup 11}C]PK11195. Additionally, clodronate-treated rats showed a depletion in microglial population and [{sup 18}F]FSPG PET signal in spinal cord confirming a link between neuroinflammatory reaction and cystine/glutamate antiporter activity in EAE rats. Altogether, these results suggest that in vivo PET imaging of system xc{sup -} could become a valuable tool for the diagnosis and treatment evaluation of MS. (orig.)

  6. Novel Approaches to Detect Serum Biomarkers for Clinical Response to Interferon-β Treatment in Multiple Sclerosis

    Science.gov (United States)

    Gandhi, Kaushal S.; McKay, Fiona C.; Diefenbach, Eve; Crossett, Ben; Schibeci, Stephen D.; Heard, Robert N.; Stewart, Graeme J.; Booth, David R.; Arthur, Jonathan W.

    2010-01-01

    Interferon beta (IFNβ) is the most common immunomodulatory treatment for relapsing-remitting multiple sclerosis (RRMS). However, some patients fail to respond to treatment. In this study, we identified putative clinical response markers in the serum and plasma of people with multiple sclerosis (MS) treated with IFNβ. In a discovery-driven approach, we use 2D-difference gel electrophoresis (DIGE) to identify putative clinical response markers and apply power calculations to identify the sample size required to further validate those markers. In the process we have optimized a DIGE protocol for plasma to obtain cost effective and high resolution gels for effective spot comparison. APOA1, A2M, and FIBB were identified as putative clinical response markers. Power calculations showed that the current DIGE experiment requires a minimum of 10 samples from each group to be confident of 1.5 fold difference at the p<0.05 significance level. In a complementary targeted approach, Cytometric Beadarray (CBA) analysis showed no significant difference in the serum concentration of IL-6, IL-8, MIG, Eotaxin, IP-10, MCP-1, and MIP-1α, between clinical responders and non-responders, despite the association of these proteins with IFNβ treatment in MS. PMID:20463963

  7. Novel approaches to detect serum biomarkers for clinical response to interferon-beta treatment in multiple sclerosis.

    Science.gov (United States)

    Gandhi, Kaushal S; McKay, Fiona C; Diefenbach, Eve; Crossett, Ben; Schibeci, Stephen D; Heard, Robert N; Stewart, Graeme J; Booth, David R; Arthur, Jonathan W

    2010-05-05

    Interferon beta (IFNbeta) is the most common immunomodulatory treatment for relapsing-remitting multiple sclerosis (RRMS). However, some patients fail to respond to treatment. In this study, we identified putative clinical response markers in the serum and plasma of people with multiple sclerosis (MS) treated with IFNbeta. In a discovery-driven approach, we use 2D-difference gel electrophoresis (DIGE) to identify putative clinical response markers and apply power calculations to identify the sample size required to further validate those markers. In the process we have optimized a DIGE protocol for plasma to obtain cost effective and high resolution gels for effective spot comparison. APOA1, A2M, and FIBB were identified as putative clinical response markers. Power calculations showed that the current DIGE experiment requires a minimum of 10 samples from each group to be confident of 1.5 fold difference at the p<0.05 significance level. In a complementary targeted approach, Cytometric Beadarray (CBA) analysis showed no significant difference in the serum concentration of IL-6, IL-8, MIG, Eotaxin, IP-10, MCP-1, and MIP-1alpha, between clinical responders and non-responders, despite the association of these proteins with IFNbeta treatment in MS.

  8. Novel approaches to detect serum biomarkers for clinical response to interferon-beta treatment in multiple sclerosis.

    Directory of Open Access Journals (Sweden)

    Kaushal S Gandhi

    Full Text Available Interferon beta (IFNbeta is the most common immunomodulatory treatment for relapsing-remitting multiple sclerosis (RRMS. However, some patients fail to respond to treatment. In this study, we identified putative clinical response markers in the serum and plasma of people with multiple sclerosis (MS treated with IFNbeta. In a discovery-driven approach, we use 2D-difference gel electrophoresis (DIGE to identify putative clinical response markers and apply power calculations to identify the sample size required to further validate those markers. In the process we have optimized a DIGE protocol for plasma to obtain cost effective and high resolution gels for effective spot comparison. APOA1, A2M, and FIBB were identified as putative clinical response markers. Power calculations showed that the current DIGE experiment requires a minimum of 10 samples from each group to be confident of 1.5 fold difference at the p<0.05 significance level. In a complementary targeted approach, Cytometric Beadarray (CBA analysis showed no significant difference in the serum concentration of IL-6, IL-8, MIG, Eotaxin, IP-10, MCP-1, and MIP-1alpha, between clinical responders and non-responders, despite the association of these proteins with IFNbeta treatment in MS.

  9. Impulsive synchronization of Markovian jumping randomly coupled neural networks with partly unknown transition probabilities via multiple integral approach.

    Science.gov (United States)

    Chandrasekar, A; Rakkiyappan, R; Cao, Jinde

    2015-10-01

    This paper studies the impulsive synchronization of Markovian jumping randomly coupled neural networks with partly unknown transition probabilities via multiple integral approach. The array of neural networks are coupled in a random fashion which is governed by Bernoulli random variable. The aim of this paper is to obtain the synchronization criteria, which is suitable for both exactly known and partly unknown transition probabilities such that the coupled neural network is synchronized with mixed time-delay. The considered impulsive effects can be synchronized at partly unknown transition probabilities. Besides, a multiple integral approach is also proposed to strengthen the Markovian jumping randomly coupled neural networks with partly unknown transition probabilities. By making use of Kronecker product and some useful integral inequalities, a novel Lyapunov-Krasovskii functional was designed for handling the coupled neural network with mixed delay and then impulsive synchronization criteria are solvable in a set of linear matrix inequalities. Finally, numerical examples are presented to illustrate the effectiveness and advantages of the theoretical results.

  10. Dealing with missing covariates in epidemiologic studies: a comparison between multiple imputation and a full Bayesian approach.

    Science.gov (United States)

    Erler, Nicole S; Rizopoulos, Dimitris; Rosmalen, Joost van; Jaddoe, Vincent W V; Franco, Oscar H; Lesaffre, Emmanuel M E H

    2016-07-30

    Incomplete data are generally a challenge to the analysis of most large studies. The current gold standard to account for missing data is multiple imputation, and more specifically multiple imputation with chained equations (MICE). Numerous studies have been conducted to illustrate the performance of MICE for missing covariate data. The results show that the method works well in various situations. However, less is known about its performance in more complex models, specifically when the outcome is multivariate as in longitudinal studies. In current practice, the multivariate nature of the longitudinal outcome is often neglected in the imputation procedure, or only the baseline outcome is used to impute missing covariates. In this work, we evaluate the performance of MICE using different strategies to include a longitudinal outcome into the imputation models and compare it with a fully Bayesian approach that jointly imputes missing values and estimates the parameters of the longitudinal model. Results from simulation and a real data example show that MICE requires the analyst to correctly specify which components of the longitudinal process need to be included in the imputation models in order to obtain unbiased results. The full Bayesian approach, on the other hand, does not require the analyst to explicitly specify how the longitudinal outcome enters the imputation models. It performed well under different scenarios. Copyright © 2016 John Wiley & Sons, Ltd.

  11. Multivariate dimensionality reduction approaches to identify gene-gene and gene-environment interactions underlying multiple complex traits.

    Directory of Open Access Journals (Sweden)

    Hai-Ming Xu

    Full Text Available The elusive but ubiquitous multifactor interactions represent a stumbling block that urgently needs to be removed in searching for determinants involved in human complex diseases. The dimensionality reduction approaches are a promising tool for this task. Many complex diseases exhibit composite syndromes required to be measured in a cluster of clinical traits with varying correlations and/or are inherently longitudinal in nature (changing over time and measured dynamically at multiple time points. A multivariate approach for detecting interactions is thus greatly needed on the purposes of handling a multifaceted phenotype and longitudinal data, as well as improving statistical power for multiple significance testing via a two-stage testing procedure that involves a multivariate analysis for grouped phenotypes followed by univariate analysis for the phenotypes in the significant group(s. In this article, we propose a multivariate extension of generalized multifactor dimensionality reduction (GMDR based on multivariate generalized linear, multivariate quasi-likelihood and generalized estimating equations models. Simulations and real data analysis for the cohort from the Study of Addiction: Genetics and Environment are performed to investigate the properties and performance of the proposed method, as compared with the univariate method. The results suggest that the proposed multivariate GMDR substantially boosts statistical power.

  12. Ansiedad y depresión en la esclerosis múltiple remitente-recidivante: relación con las alteraciones neuropsicológicas y la percepción subjetiva de deterioro cognitivo en pacientes con discapacidad mínima/leve.

    Directory of Open Access Journals (Sweden)

    Teresa Olivares-Pérez

    2009-07-01

    Full Text Available Introducción. La ansiedad y la depresión son trastornos psiquiátricos vinculados a la Esclerosis Múltiple (EM. Sin embargo, la ansiedad no ha sido prácticamente estudiada. Objetivos. Examinar la asociación de ambos trastornos con el deterioro neuropsicológico y su contribución a la autopercepción de deterioro cognitivo. Sujetos y métodos. Se estudiaron 33 pacientes con EM Remitente-Recidivante y niveles de discapacidad mínima-leve. Instrumentos: Hospital Anxiety and Depression Scale (HADS; Multiple Sclerosis Neuropsychological Screening Questionnaire; Brief Repeatable Battery of Neuropsychological Tests. El examen neuropsicológico se aplicó a 67 controles. Resultados. La ansiedad y la depresión no están relacionadas con el deterioro neuropsicológico. La gravedad de la sintomatología ansiosa está especialmente asociada a una menor duración de la EM. Ansiedad y depresión están altamente correlacionadas y ambas predicen la percepción subjetiva de deterioro. La capacidad predictiva del HADS-total sobre la percepción subjetiva de deterioro fue similar a la obtenida por las subescalas de ansiedad y depresión por separado. Conclusiones. La autopercepción de deterioro cognitivo en la EMRR con discapacidad mínima podría estar relacionada con un factor de malestar psicológico general compartido por la ansiedad y la depresión. Nuestros resultados resaltan la importancia de detectar y tratar la sintomatología ansiosa en fases iniciales de la EM.

  13. Formalized Conflicts Detection Based on the Analysis of Multiple Emails: An Approach Combining Statistics and Ontologies

    Science.gov (United States)

    Zakaria, Chahnez; Curé, Olivier; Salzano, Gabriella; Smaïli, Kamel

    In Computer Supported Cooperative Work (CSCW), it is crucial for project leaders to detect conflicting situations as early as possible. Generally, this task is performed manually by studying a set of documents exchanged between team members. In this paper, we propose a full-fledged automatic solution that identifies documents, subjects and actors involved in relational conflicts. Our approach detects conflicts in emails, probably the most popular type of documents in CSCW, but the methods used can handle other text-based documents. These methods rely on the combination of statistical and ontological operations. The proposed solution is decomposed in several steps: (i) we enrich a simple negative emotion ontology with terms occuring in the corpus of emails, (ii) we categorize each conflicting email according to the concepts of this ontology and (iii) we identify emails, subjects and team members involved in conflicting emails using possibilistic description logic and a set of proposed measures. Each of these steps are evaluated and validated on concrete examples. Moreover, this approach's framework is generic and can be easily adapted to domains other than conflicts, e.g. security issues, and extended with operations making use of our proposed set of measures.

  14. Supervised pre-processing approaches in multiple class variables classification for fish recruitment forecasting

    KAUST Repository

    Fernandes, José Antonio

    2013-02-01

    A multi-species approach to fisheries management requires taking into account the interactions between species in order to improve recruitment forecasting of the fish species. Recent advances in Bayesian networks direct the learning of models with several interrelated variables to be forecasted simultaneously. These models are known as multi-dimensional Bayesian network classifiers (MDBNs). Pre-processing steps are critical for the posterior learning of the model in these kinds of domains. Therefore, in the present study, a set of \\'state-of-the-art\\' uni-dimensional pre-processing methods, within the categories of missing data imputation, feature discretization and feature subset selection, are adapted to be used with MDBNs. A framework that includes the proposed multi-dimensional supervised pre-processing methods, coupled with a MDBN classifier, is tested with synthetic datasets and the real domain of fish recruitment forecasting. The correctly forecasting of three fish species (anchovy, sardine and hake) simultaneously is doubled (from 17.3% to 29.5%) using the multi-dimensional approach in comparison to mono-species models. The probability assessments also show high improvement reducing the average error (estimated by means of Brier score) from 0.35 to 0.27. Finally, these differences are superior to the forecasting of species by pairs. © 2012 Elsevier Ltd.

  15. A simulation-optimisation approach for designing water distribution networks under multiple objectives

    Science.gov (United States)

    Grundmann, Jens; Pham Van, Tinh; Müller, Ruben; Schütze, Niels

    2014-05-01

    Especially in arid and semi-arid regions, water distribution networks are of major importance for an integrated water resources management in order to convey water over long distances from sources to consumers. However, to design a network optimally is still a challenge which requires an appropriate determination of: (1) pipe/pump/tank characteristics - decision variables (2) cost/network reliability - objective functions including (3) a given set of constraints. Thereby, objective functions are contradicting, which means that by minimising costs network reliability is decreasing resulting in a higher risk of network failures. For solving this multi-objective design problem, a simulation-optimisation approach is developed. The approach couples a hydraulic network model (Epanet) with an optimiser, namely the covariance matrix adaptation evolution strategy (CMAES). The simulation-optimisation model is applied on international published benchmark cases for single and multi-objective optimisation and simultaneous optimisation of above mentioned decision variables as well as network layout. Results are encouraging. The proposed model performs with similar or better results, which means smaller costs and higher network reliability. Subsequently, the new model is applied for an optimal design and operation of a water distribution system to supply the coastal arid region of Al-Batinah (North of Oman) with water for agricultural production.

  16. Study on the regulatory approach of KNGR multiple steam generator tube rupture events

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Keun Sun; Kweon, Y. C.; Lee, S. J.; Lee, Y. S.; Cheong, D. Y.; Park, T. J.; Lee, M. G.; Cheon, Y. H. [Sunmoon Univ., Asan (Korea, Republic of); Cheong, J. H. [Baekseok College of Cultural Studies, Cheonan (Korea, Republic of)

    2001-10-15

    The scope and contents performed in this project are as follows : firstly, reviews of the structure and contents of local and foreign regulatory requirements as well as analysis of design features related to safety improvement and containment bypass during multiple steam generator tube failure of advanced reactors of domestic and foreign countries. Secondly, analyses of the state-of-the-art of the development of local and foreign regulatory requirements, research trends, design features and safety goals of advanced reactors, especially for technical issues related to the containment bypass during MSGTR event. Thirdly, analyses of the event of MSGTR for the KNGR using MAS 1.4 which is the best-estimate system code developed by Korea Atomic Energy Research Institute. Errors in input-decks established last year have been corrected during this analysis. Fourthly, assessment of the effects of several parameters on the consequences following a MSGTR event. Tube rupture location, selection of affected steam generator, tube modeling method, discharge coefficient (C{sub D}) are examined. Fifthly, establishment of regulatory direction of technical issues related to the containment bypass during MSGTR event.

  17. Intracolonic multiple pebbles in young adults: Radiographic imaging and conventional approach to a case

    Institute of Scientific and Technical Information of China (English)

    Mehmet Eryilmaz; Orkun Ozturk; Oner Mentes; Kenan Soylu; Murat Durusu; K(o)ksal Oner

    2006-01-01

    Most of the foreign bodies detected in adult gastrointestinal systems are accidentally swallowed pins. In this study, we presented a case with intracolonic multiple pebbles. A 20-year-old man was admitted to emergency surgery policlinic for abdominal pain for 2 d without any alleviation or aggravation. His upright plain abdominal radiographic imaging revealed about 30-40 overt dense opacities in lumen of colonic segments, with oval and well shaped contours, each approximately 1cm x 1cm in size. The multiplanar reconstructions and threedimensional images combined with sectional screening showed that all pebbles had passed completely into the colon and no foreign bodies had remained in the ileal segments. On psychiatric assessment, he was found to have immature personality features, difficulty in overcoming stressors and adaptation disorder. He recovered by conservative management and radiographic monitoring applied during his follow-up. Thus, it can be concluded that, in differential diagnosis of abdominal pain in adult ages, though less frequently seen than in children,gastrointestinal system foreign bodies should always be kept in mind and it should be considered that ingestion of pebbles may be one of the factors contributing to abdominal pain particularly in young adults with psychiatric problems. In such cases suspected of having foreign bodies which cannot be detected by plain films, abdominal tomography can be an alternative for diagnostic imaging.

  18. A Multiple Model Approach to Track Head Orientation With Delta Quaternions.

    Science.gov (United States)

    Himberg, Henry; Motai, Yuichi; Bradley, Arthur

    2013-02-01

    Virtual reality and augmented reality environments using helmet-mounted displays create a sense of immersion by closely coupling user head motion to display content. Delays in the presentation of visual information can destroy the sense of presence in the simulation environment when it causes a lag in the display response to user head motion. The effect of display lag can be minimized by predicting head orientation, allowing the system to have sufficient time to counteract the delay. In this paper, anew head orientation prediction technique is proposed that uses a multiple delta quaternion (DQ) extended Kalman filter to track angular head velocity and angular head acceleration. This method is independent of the device used for orientation measurement, relying on quaternion orientation as the only measurement data. A new orientation prediction algorithm is proposed that estimates future head orientation as a function of the current orientation measurement and a predicted change in orientation, using the velocity and acceleration estimates. Extensive experimentation shows that the new method improves head orientation prediction when compared to single filter DQ prediction.

  19. An approximate approach to sample size determination in bioequivalence testing with multiple pharmacokinetic responses.

    Science.gov (United States)

    Tsai, Chen-An; Huang, Chih-Yang; Liu, Jen-Pei

    2014-08-30

    The approval of generic drugs requires the evidence of average bioequivalence (ABE) on both the area under the concentration-time curve and the peak concentration Cmax . The bioequivalence (BE) hypothesis can be decomposed into the non-inferiority (NI) and non-superiority (NS) hypothesis. Most of regulatory agencies employ the two one-sided tests (TOST) procedure to test ABE between two formulations. As it is based on the intersection-union principle, the TOST procedure is conservative in terms of the type I error rate. However, the type II error rate is the sum of the type II error rates with respect to each null hypothesis of NI and NS hypotheses. When the difference in population means between two treatments is not 0, no close-form solution for the sample size for the BE hypothesis is available. Current methods provide the sample sizes with either insufficient power or unnecessarily excessive power. We suggest an approximate method for sample size determination, which can also provide the type II rate for each of NI and NS hypotheses. In addition, the proposed method is flexible to allow extension from one pharmacokinetic (PK) response to determination of the sample size required for multiple PK responses. We report the results of a numerical study. An R code is provided to calculate the sample size for BE testing based on the proposed methods.

  20. Epigenetic Modulating Agents as a New Therapeutic Approach in Multiple Myeloma

    Energy Technology Data Exchange (ETDEWEB)

    Maes, Ken, E-mail: kemaes@vub.ac.be; Menu, Eline; Van Valckenborgh, Els [Department of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussel (Belgium); Van Riet, Ivan [Stem Cell Laboratory, Department Clinical Hematology, Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan 101, 1090 Brussel (Belgium); Vanderkerken, Karin; De Bruyne, Elke, E-mail: kemaes@vub.ac.be [Department of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussel (Belgium)

    2013-04-15

    Multiple myeloma (MM) is an incurable B-cell malignancy. Therefore, new targets and drugs are urgently needed to improve patient outcome. Epigenetic aberrations play a crucial role in development and progression in cancer, including MM. To target these aberrations, epigenetic modulating agents, such as DNA methyltransferase inhibitors (DNMTi) and histone deacetylase inhibitors (HDACi), are under intense investigation in solid and hematological cancers. A clinical benefit of the use of these agents as single agents and in combination regimens has been suggested based on numerous studies in pre-clinical tumor models, including MM models. The mechanisms of action are not yet fully understood but appear to involve a combination of true epigenetic changes and cytotoxic actions. In addition, the interactions with the BM niche are also affected by epigenetic modulating agents that will further determine the in vivo efficacy and thus patient outcome. A better understanding of the molecular events underlying the anti-tumor activity of the epigenetic drugs will lead to more rational drug combinations. This review focuses on the involvement of epigenetic changes in MM pathogenesis and how the use of DNMTi and HDACi affect the myeloma tumor itself and its interactions with the microenvironment.

  1. A multiple degree of freedom modeling approach of piezoelectret foam in a multilayer stack configuration

    Science.gov (United States)

    Tefft, Edward C.; Anton, Steven R.

    2016-04-01

    As electronic devices become both ubiquitous and more energy efficient, powering them with energy harvested from, for example, piezoelectric materials has become a subject of much interest. The field does indeed show promise, as harvesting energy from smart materials has the potential to replace batteries completely in some low-power applications. This paper presents modeling of piezo-electret foam assembled in a multilayer stack configuration, with the required adhesives and conductors, as a multiple degree of freedom (MDOF) system. The benefits of using the foam over some piezo-ceramics include its high flexibility, its light weight, and its lead-free composition. This model predicts the mechanical and electromechanical response to base excitation for any number of layers of piezo-electret foam. Building upon previous work which modeled the piezo-electret stack as a single degree of freedom (SDOF) system, the MDOF model provides information concerning the response of internal stack layers. The MDOF model is validated against the experimentally determined mechanical and electrical responses of a 20-layer piezo-electret foam stack. Also, the internal stack dynamics at higher order vibration modes suggest that charge cancellation is a serious outcome of vibration at these modes that designers need to consider.

  2. Classification of Hypertrophy of Labia Minora: Consideration of a Multiple Component Approach.

    Science.gov (United States)

    González, Pablo I

    2015-11-01

    Labia minora hypertrophy of unknown and under-reported incidence in the general population is considered a variant of normal anatomy. Its origin is multi-factorial including genetic, hormonal, and infectious factors, and voluntary elongation of the labiae minorae in some cultures. Consults with patients bothered by this condition have been increasing with patients complaining of poor aesthetics and symptoms such as difficulty with vaginal secretions, vulvovaginitis, chronic irritation, and superficial dyspareunia, all of which can have a negative effect on these patients' sexuality and self esteem. Surgical management of labial hypertrophy is an option for women with these physical complaints or aesthetic issues. Labia minora hypertrophy can consist of multiple components, including the clitoral hood, lateral prepuce, frenulum, and the body of the labia minora. To date, there is not a consensus in the literature with respect to the classification and definition of varying grades of hypertrophy, aside from measurement of the length in centimeters. In order to offer patients the most appropriate surgical technique, an objective and understandable classification that can be used as part of the preoperative evaluation is necessary. Such a classification should have the aim of offering patients the best cosmetic and functional results with the fewest complications.

  3. A Hybrid Multiple-Criteria Decision-Making Approach for Photovoltaic Solar Plant Location Selection

    Directory of Open Access Journals (Sweden)

    Amy H. I. Lee

    2017-01-01

    Full Text Available Due to decaying fossil resource and increasing environmental consciousness, the demand of renewable energy resources is escalating these days. Photovoltaic solar energy is one of the most popular renewable energy resources in places where sunlight is abundant. The selection of a desirable location for constructing a photovoltaic solar plant is the first and one of the most important stages in the plant construction to provide a long-term energy production. In this paper, a comprehensive multiple-criteria decision-making model, which incorporates the interpretive structural modeling (ISM, fuzzy analytic network process (FANP and VIKOR (VlseKriterijumska OptimizacijaI Kompromisno Resenje in Serbian,meaning multi-criteria optimization and compromise solution, is proposed to select the most suitable photovoltaic solar plant location. The ISM is applied first to determine the interrelationships among the criteria and among the sub-criteria,andtheresults are used to construct a decision-making network. The FANP is applied next to solve the network and to calculate the importance weights of the sub-criteria. Finally, the VIKOR is adopted to determine the ranking of the photovoltaic solar plant locations. The proposed model is applied in a case study in evaluating photovoltaic solar plant locations in Taiwan. By applying the proposed model, decision makers can have a better thinking process and make more appropriate decisions justifiably.

  4. Full Three Dimensional Orbits For Multiple Stars on Close Approaches to the Central Supermassive Black Hole

    CERN Document Server

    Ghez, A M; Duchêne, G; Hornstein, S D; Morris, M; Salim, S; Tanner, A

    2003-01-01

    With the advent of adaptive optics on the W. M. Keck 10 m telescope, two significant steps forward have been taken in building the case for a supermassive black hole at the center of the Milky Way and understanding the black hole's effect on its environment. Using adaptive optics and speckle imaging to study the motions of stars in the plane of sky with +-~2 mas precision over the past 7 years, we have obtained the first simultaneous orbital solution for multiple stars. Among the included stars, three are newly identified (S0-16, S0-19, S0-20). The most dramatic orbit is that of the newly identified star S0-16, which passed a mere 60 AU from the central dark mass at a velocity of 9,000 km/s in 1999. The orbital analysis results in a new central dark mass estimate of 3.6(+-0.4)x10^6(D/8kpc)^3 Mo. This dramatically strengthens the case for a black hole at the center of our Galaxy, by confining the dark matter to within a radius of 0.0003 pc or 1,000 Rsh and thereby increasing the inferred dark mass density by f...

  5. Nanoparticle delivery systems, general approaches, and their implementation in multiple myeloma.

    Science.gov (United States)

    de la Puente, Pilar; Azab, Abdel Kareem

    2017-02-16

    Multiple myeloma (MM) is a hematological malignancy that remains incurable, with relapse rates >90%. The main limiting factor for the effective use of chemotherapies in MM is the serious side effects caused by these drugs. The emphasis in cancer treatment has shifted from cytotoxic, non-specific chemotherapies to molecularly targeted and rationally designed therapies showing greater efficacy and fewer side effects. Traditional chemotherapy has shown several disadvantages such as lack of targeting capabilities, systemic toxicity, and side effects; low therapeutic index, as well as most anticancer drugs, has poor water solubility. Nanoparticle delivery systems (NPs) are capable of targeting large doses of chemotherapies into the target area while sparing healthy tissues, overcoming the limitations of traditional chemotherapy. Here, we review the current state of the art in nanoparticle-based strategies designed to treat MM. Many nanoparticle delivery systems have been studied for myeloma using non-targeted NPs (liposomes, polymeric NPs, and inorganic NPs), triggered NPs, as well as targeted NPs (VLA-4, ABC drug transporters, bone microenvironment targeting). The results in preclinical and clinical studies are promising; however, there remains much to be learned in the emerging field of nanomedicine in myeloma.

  6. A Latent Variable Approach for Meta-Analysis of Gene Expression Data from Multiple Microarray Experiments

    Directory of Open Access Journals (Sweden)

    Chinnaiyan Arul M

    2007-09-01

    Full Text Available Abstract Background With the explosion in data generated using microarray technology by different investigators working on similar experiments, it is of interest to combine results across multiple studies. Results In this article, we describe a general probabilistic framework for combining high-throughput genomic data from several related microarray experiments using mixture models. A key feature of the model is the use of latent variables that represent quantities that can be combined across diverse platforms. We consider two methods for estimation of an index termed the probability of expression (POE. The first, reported in previous work by the authors, involves Markov Chain Monte Carlo (MCMC techniques. The second method is a faster algorithm based on the expectation-maximization (EM algorithm. The methods are illustrated with application to a meta-analysis of datasets for metastatic cancer. Conclusion The statistical methods described in the paper are available as an R package, metaArray 1.8.1, which is at Bioconductor, whose URL is http://www.bioconductor.org/.

  7. Ensemble approach combining multiple methods improves human transcription start site prediction

    LENUS (Irish Health Repository)

    Dineen, David G

    2010-11-30

    Abstract Background The computational prediction of transcription start sites is an important unsolved problem. Some recent progress has been made, but many promoters, particularly those not associated with CpG islands, are still difficult to locate using current methods. These methods use different features and training sets, along with a variety of machine learning techniques and result in different prediction sets. Results We demonstrate the heterogeneity of current prediction sets, and take advantage of this heterogeneity to construct a two-level classifier (\\'Profisi Ensemble\\') using predictions from 7 programs, along with 2 other data sources. Support vector machines using \\'full\\' and \\'reduced\\' data sets are combined in an either\\/or approach. We achieve a 14% increase in performance over the current state-of-the-art, as benchmarked by a third-party tool. Conclusions Supervised learning methods are a useful way to combine predictions from diverse sources.

  8. A Multiple Source Approach to Organisational Justice: The Role of the Organisation, Supervisors, Coworkers, and Customers

    Directory of Open Access Journals (Sweden)

    Agustin Molina

    2015-07-01

    Full Text Available The vast research on organisational justice has focused on the organisation and the supervisor. This study aims to further this line of research by integrating two trends within organisational justice research: the overall approach to justice perceptions and the multifoci perspective of justice judgments. Specifically, this study aims to explore the effects of two additional sources of justice, coworker-focused justice and customer-focused justice, on relevant employees’ outcomes—burnout, turnover intentions, job satisfaction, and workplace deviance— while controlling the effect of organisation-focused justice and supervisor-focused justice. Given the increased importance attributed to coworkers and customers, we expect coworker-focused justice and customer-focused justice to explain incremental variance in the measured outcomes, above and beyond the effects of organisation-focused justice and supervisor-focused justice. Participants will be university students from Austria and Germany employed by service organisations. Data analysis will be conducted using structural equation modeling.

  9. Multiple Perspective Approach for the Development of Information Systems Based on Advanced Mathematical Models

    DEFF Research Database (Denmark)

    Carugati, Andrea

    . The resulting methodology builds on these four results. The methodology is based on an emergent and iterative process focused on the discussion of software prototypes built as boundary objects: visual, usable, bi-directional, and up-to-date. Iterations are kept short so that the prototypes remain simple enough...... modeling (AMM) in scheduling and control systems. Advanced mathematical techniques are relatively new in scheduling and control systems, at least in real production situations, and therefore the project included the research of methods and tools for the development of these systems. Because of the novelty...... with a relativist approach. Arriving at the design of an ISD methodology required the combination of previous theoretical results with the observations from the case study. The case study showed some of the key elements to be integrated in the methodology. Firstly, plans and models are subject of a high degree...

  10. Alemtuzumab Induced Thyroid Disease in Multiple Sclerosis: A Review and Approach to Management.

    Science.gov (United States)

    Mahzari, Moeber; Arnaout, Amel; Freedman, Mark S

    2015-09-01

    Alemtuzumab, an anti-CD52 monoclonal antibody, was recently approved for treatment of MS in Canada, having shown to significantly reduce relapses and disability in patients, particularly those who relapsed despite first line treatment. Offsetting its benefit however, is the development of novel secondary autoimmune disease, particularly affecting the thyroid gland in up to 36% of patients. The incidence of Alemtuzumab induced thyroid dysfunction (AITD) will likely rise as alemtuzumab becomes more widely used for treating MS. We review the clinical and investigational cues that help delineate the aetiology and management of thyrotoxicosis and hypothyroidism in ATID. AITD can be easily managed and we present a simple approach for its evaluation and management by neurologists that should be implemented prior to considering a referral to an internist or endocrinologist for further opinion or treatment.

  11. Scenario Based Approach for Multiple Source Tsunami Hazard Assessment for Sines, Portugal

    Science.gov (United States)

    Wronna, Martin; Omira, Rachid; Baptista, Maria Ana

    2015-04-01

    In this paper, we present a scenario-based approach for tsunami hazard assessment for the city and harbour of Sines, Portugal one the test-sites of project ASTARTE. Sines holds one of the most important deep-water ports which contains oil-bearing, petrochemical, liquid bulk, coal and container terminals. The port and its industrial infrastructures are facing the ocean to the southwest facing the main seismogenic sources. This work considers two different seismic zones: the Southwest Iberian Margin and the Gloria Fault. Within these two regions, a total of five scenarios were selected to assess tsunami impact at the test site. These scenarios correspond to the worst-case credible scenario approach based upon the largest events of the historical and paleo tsunami catalogues. The tsunami simulations from the source area towards the coast is carried out using NSWING a Non-linear Shallow Water Model With Nested Grids. The code solves the non-linear shallow water equations using the discretization and explicit leap-frog finite difference scheme, in a Cartesian or Spherical frame. The initial sea surface displacement is assumed to be equal to the sea bottom deformation that is computed by Okada equations. Both uniform and non-uniform slip conditions are used. The presented results correspond to the models using non-uniform slip conditions. In this study, the static effect of tides is analysed for three different tidal stages MLLW (mean lower low water) MSL (mean sea level) and MHHW (mean higher high water). For each scenario, inundation is described by maximum values of wave height, flow depth, drawdown, run-up and inundation distance. Synthetic waveforms are computed at virtual tide gages at specific locations outside and inside the harbour. The final results consist of Aggregate Scenario Maps presented for the different inundation parameters. This work is funded by ASTARTE - Assessment, Strategy And Risk Reduction for Tsunamis in Europe - FP7-ENV2013 6.4-3, Grant 603839

  12. MANAGEMENT OF POSTURAL LOW BACK PAIN AMONG THE INFORMATION TECHNOLOGY PROFESSIONALS: A MULTIPLE THERAPUETIC INTERVENTION APPROACH

    Directory of Open Access Journals (Sweden)

    Shahul Hameed Pakkir Mohamed

    2015-12-01

    Full Text Available Objective: This study aimed to find out the effectiveness of multiple therapeutic intervention combinations to manage Postural Low back pain among the Information Technology [IT] Professionals. Study design: The randomized control study design. Materials and Methods: All the subjects (N=90 were randomized into three groups which consists of one control and two experimental groups. The subjects in the Experimental group I were given Motor Control Training and Ergonomic Training whereas the Experimental group II were given Myofascial Release, Motor Control Training and Ergonomic Training was given for a period of 6 weeks that includes first 3 weeks of Myofascial Release along with Motor Control Training and Ergonomic Training, further the Motor Control Training and Ergonomic Training was continued for the period of 4 to 6 weeks duration. The subjects in the control group were not given any therapeutic modalities throughout the study. The effectiveness of the therapeutic interventions were measured through three outcome parameters such as Back pain intensity, Back pain disability and Transversus Abdominis muscle strength. The Analysis of Covariance and Scheffe’s post hoc tests were applied to study the treatment effectiveness. The effectiveness of the therapeutic intervention at three different time intervals was also analyzed using repeated measures ANOVA and if found significant, a Newman Keul’s post hoc tests was employed to study the significance between two time intervals. Results & Conclusion: The results of this study concluded that the Experimental group-II is found to be better than Experimental group-I and Control group in the reduction of Low Back pain intensity, Back pain disability and Transversus Abdominis muscle strength of the Software professionals with Postural low back pain.

  13. Predicting aquatic toxicities of chemical pesticides in multiple test species using nonlinear QSTR modeling approaches.

    Science.gov (United States)

    Basant, Nikita; Gupta, Shikha; Singh, Kunwar P

    2015-11-01

    In this study, we established nonlinear quantitative-structure toxicity relationship (QSTR) models for predicting the toxicities of chemical pesticides in multiple aquatic test species following the OECD (Organization for Economic Cooperation and Development) guidelines. The decision tree forest (DTF) and decision tree boost (DTB) based QSTR models were constructed using a pesticides toxicity dataset in Selenastrum capricornutum and a set of six descriptors. Other six toxicity data sets were used for external validation of the constructed QSTRs. Global QSTR models were also constructed using the combined dataset of all the seven species. The diversity in chemical structures and nonlinearity in the data were evaluated. Model validation was performed deriving several statistical coefficients for the test data and the prediction and generalization abilities of the QSTRs were evaluated. Both the QSTR models identified WPSA1 (weighted charged partial positive surface area) as the most influential descriptor. The DTF and DTB QSTRs performed relatively better than the single decision tree (SDT) and support vector machines (SVM) models used as a benchmark here and yielded R(2) of 0.886 and 0.964 between the measured and predicted toxicity values in the complete dataset (S. capricornutum). The QSTR models applied to six other aquatic species toxicity data yielded R(2) of >0.92 (DTF) and >0.97 (DTB), respectively. The prediction accuracies of the global models were comparable with those of the S. capricornutum models. The results suggest for the appropriateness of the developed QSTR models to reliably predict the aquatic toxicity of chemicals and can be used for regulatory purpose.

  14. Therapeutic approach by Aloe vera in experimental model of multiple sclerosis.

    Science.gov (United States)

    Mirshafiey, A; Aghily, B; Namaki, S; Razavi, A; Ghazavi, A; Ekhtiari, P; Mosayebi, G

    2010-09-01

    Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that leads to an inflammatory demyelination, axonal damage, and progressive neurologic disability that affects approximately 2.5 million people worldwide. The aim of the present research was to test the therapeutic effect of Aloe vera in experimental model of MS. All experiments were conducted on C57BL/6 male mice aged 6-8 weeks. To induce the experimental autoimmune encephalomyelitis (EAE), 250 microg of the myelin oligodendrocyte glycoprotein 35-55 peptide emulsified in complete freund's adjuvant was injected subcutaneously on day 0 over two flank areas. In addition, 200 ng of pertussis toxin in 100 microL phosphate buffered saline was injected intraperitoneally on days 0 and 2. The therapeutic protocol was carried out intragastrically using 120 mg/kg/day Aloe vera from 7 days before to 21 days after EAE induction. The mice were killed 21 days after EAE induction. The brains of mice were removed for histological analysis and their isolated splenocytes were cultured. The results indicated that treatment with Aloe vera caused a significant reduction in severity of the disease in experimental model of MS. Histological analysis showed 3 +/- 2 plaques in Aloe vera-treated mice compared with 5 +/- 1 plaques in control group. The density of mononuclear infiltration in the CNS of Aloe vera-treated mice (500 +/- 200) was significantly less in comparison to 700 +/- 185 cells in control group. Moreover, the serum level of nitric oxide in treatment group was significantly less than control animals. The level of interferon-gamma in cell culture supernatant of treated mice splenocytes was lower than control group, whereas decrease in serum level of interleukin-10 in treatment group was not significant in comparison with control mice. These data indicate that Aloe vera therapy can attenuate the disease progression in experimental model of MS.

  15. Projecte EM-Line!: programa de rehabilitación cognitiva para pacientes afectados de esclerosis múltiple

    OpenAIRE

    Gich Fullà, Jordi

    2013-01-01

    The clinical manifestations of Multiple Sclerosis are motor, sensitive, cerebellar and cognitive alterations. It evolves with a high degree of physical and cognitive disability. The “EM-line! Project” has its origins in the need to provide effective treatment for cognitive problems given that a gap in cognitive treatment was detected, especially at the onset of the disease. For this reason, the main objective of the “EM-line! Project” was: To supply free cognitive rehabilitation materials th...

  16. ADMET Evaluation in Drug Discovery. 16. Predicting hERG Blockers by Combining Multiple Pharmacophores and Machine Learning Approaches.

    Science.gov (United States)

    Wang, Shuangquan; Sun, Huiyong; Liu, Hui; Li, Dan; Li, Youyong; Hou, Tingjun

    2016-08-01

    Blockade of human ether-à-go-go related gene (hERG) channel by compounds may lead to drug-induced QT prolongation, arrhythmia, and Torsades de Pointes (TdP), and therefore reliable prediction of hERG liability in the early stages of drug design is quite important to reduce the risk of cardiotoxicity-related attritions in the later development stages. In this study, pharmacophore modeling and machine learning approaches were combined to construct classification models to distinguish hERG active from inactive compounds based on a diverse data set. First, an optimal ensemble of pharmacophore hypotheses that had good capability to differentiate hERG active from inactive compounds was identified by the recursive partitioning (RP) approach. Then, the naive Bayesian classification (NBC) and support vector machine (SVM) approaches were employed to construct classification models by integrating multiple important pharmacophore hypotheses. The integrated classification models showed improved predictive capability over any single pharmacophore hypothesis, suggesting that the broad binding polyspecificity of hERG can only be well characterized by multiple pharmacophores. The best SVM model achieved the prediction accuracies of 84.7% for the training set and 82.1% for the external test set. Notably, the accuracies for the hERG blockers and nonblockers in the test set reached 83.6% and 78.2%, respectively. Analysis of significant pharmacophores helps to understand the multimechanisms of action of hERG blockers. We believe that the combination of pharmacophore modeling and SVM is a powerful strategy to develop reliable theoretical models for the prediction of potential hERG liability.

  17. MultiDK: A Multiple Descriptor Multiple Kernel Approach for Molecular Discovery and Its Application to The Discovery of Organic Flow Battery Electrolytes

    CERN Document Server

    Kim, Sung-Jin; Aspuru-Guzik, Alán

    2016-01-01

    We propose a multiple descriptor multiple kernel (MultiDK) method for efficient molecular discovery using machine learning. We show that the MultiDK method improves both the speed and the accuracy of molecular property prediction. We apply the method to the discovery of electrolyte molecules for aqueous redox flow batteries. Using \\emph{multiple-type - as opposed to single-type - descriptors}, more relevant features for machine learning can be obtained. Following the principle of the 'wisdom of the crowds', the combination of multiple-type descriptors significantly boosts prediction performance. Moreover, MultiDK can exploit irregularities between molecular structure and property relations better than the linear regression method by employing multiple kernels - more than one kernel functions for a set of the input descriptors. The multiple kernels consist of the Tanimoto similarity function and a linear kernel for a set of binary descriptors and a set of non-binary descriptors, respectively. Using MultiDK, we...

  18. Parallel optimization and genotyping of multiple single-nucleotide polymorphism markers by sample pooling approach using cycling-gradient CE with multiple injections.

    Science.gov (United States)

    Minarik, Marek; Benesova, Lucie; Fantova, Lucie; Horacek, Jiri; Heracek, Jiri; Loukola, Anu

    2006-10-01

    Increasing importance of single-nucleotide polymorphisms (SNPs) in determination of disease susceptibility or in prediction of therapy response brings attention of many molecular diagnostic laboratories to simple and low-cost SNP genotyping methodologies. We have recently introduced a mutation detection technique based on analysis of homo- and heteroduplex PCR fragments resolved in cycling temperature gradient conditions on a conventional multicapillary-array DNA sequencer. The main advantage of this technique is in its simplicity with no requirement for sample cleanup prior to the analysis. In this report we present a practical application of the technology for genotyping of SNP markers in two separate clinical projects resulting in a combined set of 44 markers screened in over 500 patients. Initially, a design of PCR primers and conditions was performed for each SNP marker. Then, optimization of CE running conditions (limited just to the proper selection of temperature cycling) was performed on pools of 20 DNA samples to increase the probability of having each of the two allele types represented in the sample. After selecting the optimum conditions, screening of markers in patients was performed using a multiple-injection approach for further acceleration of the sample throughput. The rate of successful optimization of experimental conditions without any pre-selection based on the SNP sequence or melting characteristics was 80% from the initial SNP marker candidates. By studying the failed markers, we attempt to identify critical factors enabling successful typing. The presented technique is very useful for low to medium sized SNP genotyping projects mostly applied in pharmacogenomic research as well as in clinical diagnostics. The main advantages include low cost, simple setup and validation of SNP markers.

  19. A comparison of biogenic iron quotas during a diatom spring bloom using multiple approaches

    Directory of Open Access Journals (Sweden)

    A. L. King

    2011-09-01

    Full Text Available Biogenic Fe quotas were determined using three distinct techniques on samples collected concurrently in the subtropical Pacific Ocean east of New Zealand. Fe quotas were measured using radioisotope uptake experiments (24 h incubation, bulk filtration and analysis by inductively-coupled plasma mass spectrometer (ICPMS, and single-cell synchrotron x-ray fluorescence (SXRF analysis over a sixteen-day period (year days 263 to 278 of 2008 during a quasi-Lagrangian drifter experiment that tracked the evolution of the annual spring diatom bloom within a counter-clockwise open-ocean eddy. Overall, radioisotope uptake-determined Fe quotas (washed with oxalate reagent to remove extracellular Fe were the lowest (0.5–1.0 mmol Fe:mol P; 4–8 μmol Fe:mol C, followed by single-cell Fe quotas (2.3–7.5 mmol Fe:mol P; 17–57 μmol Fe:mol C, and the highest and most variable quotas were from the bulk filtration ICPMS approach that used the oxalate reagent wash, corrected for lithogenic Fe using Al (0.8–21 mmol Fe:mol P; 4–136 μmol Fe:mol C. During the evolution of the spring bloom within the eddy (year days 263 to 272, the surface mixed layer inventories of particulate organic elements (C, N, P, Si and chlorophyll increased while Fe quotas estimated from all three approaches exhibited a general decline. After the onset of the bloom decline, the drogued buoys exited the eddy center (days 273 to 277. Fe quotas returned to pre-bloom values during this part of the study. Our standardized and coordinated sampling protocols reveal the general observed trend in Fe quotas: ICPMS > SXRF > radioisotope uptake. We discuss the inherent differences between the techniques and argue that each technique has its individual merits and uniquely contributes to the characterization of the oceanic particulate Fe pool.

  20. A comparison of biogenic iron quotas during a diatom spring bloom using multiple approaches

    Directory of Open Access Journals (Sweden)

    A. L. King

    2012-02-01

    Full Text Available Biogenic Fe quotas were determined using three distinct techniques on samples collected concurrently in the subtropical Pacific Ocean east of New Zealand. Fe quotas were measured using radioisotope uptake experiments (24 h incubation, bulk filtration and analysis by inductively-coupled plasma mass spectrometer (ICPMS, and single-cell synchrotron x-ray fluorescence (SXRF analysis over a sixteen-day period (year days 263 to 278 of 2008 during a quasi-Lagrangian drifter experiment that tracked the evolution of the annual spring diatom bloom within a counter-clockwise open-ocean eddy. Overall, radioisotope uptake-determined Fe quotas (washed with oxalate reagent to remove extracellular Fe were the lowest (0.5–1.0 mmol Fe:mol P; 4–8 μmol Fe:mol C, followed by single-cell Fe quotas (2.3–7.5 mmol Fe:mol P; 17–57 μmol Fe:mol C, and the highest and most variable quotas were from the bulk filtration ICPMS approach that used the oxalate reagent wash, corrected for lithogenic Fe using Al (0.8–21 mmol Fe:mol P; 4–136 μmol Fe:mol C. During the evolution of the spring bloom within the eddy (year days 263 to 272, the surface mixed layer inventories of particulate biogenic elements (C, N, P, Si and chlorophyll increased while Fe quotas estimated from all three approaches exhibited a general decline. After the onset of the bloom decline, the drogued buoys exited the eddy center (days 273 to 277. Fe quotas returned to pre-bloom values during this part of the study. Our standardized and coordinated sampling protocols reveal the general observed trend in Fe quotas: ICPMS > SXRF > radioisotope uptake. We discuss the inherent differences between the techniques and argue that each technique has its individual merits and uniquely contributes to the characterization of the oceanic particulate Fe pool.

  1. Energy production through organic fraction of municipal solid waste-A multiple regression modeling approach.

    Science.gov (United States)

    Ramesh, N; Ramesh, S; Vennila, G; Abdul Bari, J; MageshKumar, P

    2016-12-01

    In the 21st century, people migrated from rural to urban areas for several reasons. As a result, the populations of Indian cities are increasing day by day. On one hand, the country is developing in the field of science and technology and on the other hand, it is encountering a serious problem called 'Environmental degradation'. Due to increase in population, the generation of solid waste is also increased and is being disposed in open dumps and landfills which lead to air and land pollution. This study is attempted to generate energy out of organic solid waste by the bio- fermentation process. The study was conducted for a period of 7 months at Erode, Tamilnadu and the reading on various parameters like Hydraulic retention time, organic loading rate, sludge loading rate, influent pH, effluent pH, inlet volatile acids, out let volatile fatty acids, inlet VSS/TS ratio, outlet VSS/TS ratio, influent COD, effluent COD and % of COD removal are recorded for every 10 days. The aim of the present study is to develop a model through multiple linear regression analysis with COD as dependent variable and various parameters like HRT, OLR, SLR, influent, effluent, VSS/TS ratio, influent COD, effluent COD, etc as independent variables and to analyze the impact of these parameters on COD. The results of the model developed through step-wise regression method revealed that only four parameters Influent COD, effluent COD, VSS/TS and Influent/pH were main influencers of COD removal. The parameters influent COD and VSS/TS have positive impact on COD removal and the parameters effluent COD and Influent/pH have negative impact. The parameter Influent COD has the highest order of impact, followed by effluent COD, VSS/TS and influent pH. The other parameters HRT, OLR, SLR, INLET VFA and OUTLET VFA were not significantly contributing to the removal of COD. The implementation of the process suggested through this study might bring in dual benefit to the community, viz treatment of solid

  2. Manipulation of orthogonal neural systems together in electrophysiological recordings: the MONSTER approach to simultaneous assessment of multiple neurocognitive dimensions.

    Science.gov (United States)

    Kappenman, Emily S; Luck, Steven J

    2012-01-01

    Event-related potentials (ERPs) are a powerful tool in understanding and evaluating cognitive, affective, motor, and sensory processing in both healthy and pathological samples. A typical ERP recording session takes considerable time but is designed to isolate only 1-2 components. Although this is appropriate for most basic science purposes, it is an inefficient approach for measuring the broad set of neurocognitive functions that may be disrupted in a neurological or psychiatric disease. The present study provides a framework for more efficiently evaluating multiple neural processes in a single experimental paradigm through the manipulation of functionally orthogonal dimensions. We describe the general MONSTER (Manipulation of Orthogonal Neural Systems Together in Electrophysiological Recordings) approach and explain how it can be adapted to investigate a variety of neurocognitive domains, ERP components, and neural processes of interest. We also demonstrate how this approach can be used to assess group differences by providing data from an implementation of the MONSTER approach in younger (18-30 y of age) and older (65-85 y of age) adult samples. This specific implementation of the MONSTER framework assesses 4 separate neural processes in the visual domain: (1) early sensory processing, using the C1 wave; (2) shifts of covert attention, with the N2pc component; (3) categorization, with the P3 component; and (4) self-monitoring, with the error-related negativity. Although the MONSTER approach is primarily described in the context of ERP experiments, it could also be adapted easily for use with functional magnetic resonance imaging.

  3. The efficacy and safety of natalizumab for the treatment of multiple sclerosis in Portugal: a retrospective study.

    Science.gov (United States)

    Sousa, L; de Sa, J; Sa, M J; Cerqueira, J J; Martins-Silva, A

    2014-11-01

    Introduccion. Los estudios han demostrado que el natalizumab constituye un tratamiento eficaz contra la esclerosis multiple remitente recurrente (EMRR). Hasta la fecha, no habia datos de pacientes portugueses. Objetivo. Determinar la eficacia y la seguridad del natalizumab en pacientes con EMRR atendidos en la practica clinica ordinaria en Portugal. Pacientes y metodos. Los datos clinicos de adultos con EMRR tratados con natalizumab en centros especializados de neurologia en Portugal se introdujeron de forma retrospectiva en una base de datos para llevar a cabo un analisis entre octubre de 2010 y febrero de 2012. Se analizo el cambio en la tasa anualizada de brotes (TAB), en las puntuaciones de la escala ampliada de discapacidad (EDSS) y en el estado de discapacidad. Resultados. Se admitio un total de 383 pacientes atendidos en 20 centros. Antes de iniciar el tratamiento con natalizumab, la mediana inicial de la EDSS era de 4,0 y la TAB media, de 1,64. La mayor parte de los pacientes ya habia recibido tratamiento contra la esclerosis multiple (93,0%). La duracion media del tratamiento con natalizumab era de 12 meses. El tratamiento propicio reducciones significativas (p = 12 meses (n = 288) y durante >= 24 meses (n = 160). El natalizumab resulto mas eficaz en los pacientes que presentaban un menor grado de discapacidad (EDSS discapacidad y en aquellos que no han recibido ningun tratamiento modificador de la enfermedad hasta el momento.

  4. Ecosystem services sustainability in the Mediterranean Sea: assessment of status and trends using multiple modelling approaches

    Science.gov (United States)

    Liquete, Camino; Piroddi, Chiara; Macías, Diego; Druon, Jean-Noël; Zulian, Grazia

    2016-01-01

    Mediterranean ecosystems support important processes and functions that bring direct benefits to human society. Yet, marine ecosystem services are usually overlooked due to the challenges in identifying and quantifying them. This paper proposes the application of several biophysical and ecosystem modelling approaches to assess spatially and temporally the sustainable use and supply of selected marine ecosystem services. Such services include food provision, water purification, coastal protection, lifecycle maintenance and recreation, focusing on the Mediterranean region. Overall, our study found a higher number of decreasing than increasing trends in the natural capacity of the ecosystems to provide marine and coastal services, while in contrast the opposite was observed to be true for the realised flow of services to humans. Such a study paves the way towards an effective support for Blue Growth and the European maritime policies, although little attention is paid to the quantification of marine ecosystem services in this context. We identify a key challenge of integrating biophysical and socio-economic models as a necessary step to further this research. PMID:27686533

  5. Numerical evaluation of the bispectrum in multiple field inflation—the transport approach with code

    Science.gov (United States)

    Dias, Mafalda; Frazer, Jonathan; Mulryne, David J.; Seery, David

    2016-12-01

    We present a complete framework for numerical calculation of the power spectrum and bispectrum in canonical inflation with an arbitrary number of light or heavy fields. Our method includes all relevant effects at tree-level in the loop expansion, including (i) interference between growing and decaying modes near horizon exit; (ii) correlation and coupling between species near horizon exit and on superhorizon scales; (iii) contributions from mass terms; and (iv) all contributions from coupling to gravity. We track the evolution of each correlation function from the vacuum state through horizon exit and the superhorizon regime, with no need to match quantum and classical parts of the calculation; when integrated, our approach corresponds exactly with the tree-level Schwinger or `in-in' formulation of quantum field theory. In this paper we give the equations necessary to evolve all two- and three-point correlation functions together with suitable initial conditions. The final formalism is suitable to compute the amplitude, shape, and scale dependence of the bispectrum in models with |fNL| of order unity or less, which are a target for future galaxy surveys such as Euclid, DESI and LSST. As an illustration we apply our framework to a number of examples, obtaining quantitatively accurate predictions for their bispectra for the first time. Two accompanying reports describe publicly-available software packages that implement the method.

  6. Artificial multiple criticality and phase equilibria: an investigation of the PC-SAFT approach.

    Science.gov (United States)

    Yelash, Leonid; Müller, Marcus; Paul, Wolfgang; Binder, Kurt

    2005-11-01

    The perturbed-chain statistical associating fluid theory (PC-SAFT) is studied for a wide range of temperature, T, pressure, p, and (effective) chain length, m, to establish the generic phase diagram of polymers according to this theory. In addition to the expected gas-liquid coexistence, two additional phase separations are found, termed "gas-gas" equilibrium (at very low densities) and "liquid-liquid" equilibrium (at densities where the system is expected to be solid already). These phase separations imply that in one-component polymer systems three critical points occur, as well as equilibria of three fluid phases at triple points. However, Monte Carlo simulations of the corresponding system yield no trace of the gas-gas and liquid-liquid equilibria, and we conclude that the latter are just artefacts of the PC-SAFT approach. Using PC-SAFT to correlate data for polybutadiene melts, we suggest that discrepancies in modelling the polymer density at ambient temperature and high pressure can be related to the presumably artificial liquid-liquid phase separation at lower temperatures. Thus, particular care is needed in engineering applications of the PC-SAFT theory that aims at predicting properties of macromolecular materials.

  7. Cardiovascular disease risk reduction for tenth graders. A multiple-factor school-based approach.

    Science.gov (United States)

    Killen, J D; Telch, M J; Robinson, T N; Maccoby, N; Taylor, C B; Farquhar, J W

    All tenth graders in four senior high schools (N = 1447) from two school districts participated in a cardiovascular disease risk-reduction trial. Within each district, one school was assigned at random to receive a special 20-session risk-reduction intervention and one school served as a control. At a two-month follow-up, risk factor knowledge scores were significantly greater for students in the treatment group. Compared with controls, a higher proportion of those in the treatment group who were not exercising regularly at baseline reported regular exercise at follow-up. Almost twice as many baseline experimental smokers in the treatment group reported quitting at follow-up, while only 5.6% of baseline experimental smokers in the treatment group graduated to regular smoking compared with 10.3% in the control group. Students in the treatment group were more likely to report that they would choose "heart-healthy" snack items. Beneficial treatment effects were observed for resting heart rate, body mass index, triceps skin fold thickness, and subscapular skin fold thickness. The results suggest that it is feasible to provide cardiovascular disease risk-reduction training to a large segment of the population through school-based primary prevention approaches.

  8. Ecosystem services sustainability in the Mediterranean Sea: assessment of status and trends using multiple modelling approaches

    Science.gov (United States)

    Liquete, Camino; Piroddi, Chiara; Macías, Diego; Druon, Jean-Noël; Zulian, Grazia

    2016-09-01

    Mediterranean ecosystems support important processes and functions that bring direct benefits to human society. Yet, marine ecosystem services are usually overlooked due to the challenges in identifying and quantifying them. This paper proposes the application of several biophysical and ecosystem modelling approaches to assess spatially and temporally the sustainable use and supply of selected marine ecosystem services. Such services include food provision, water purification, coastal protection, lifecycle maintenance and recreation, focusing on the Mediterranean region. Overall, our study found a higher number of decreasing than increasing trends in the natural capacity of the ecosystems to provide marine and coastal services, while in contrast the opposite was observed to be true for the realised flow of services to humans. Such a study paves the way towards an effective support for Blue Growth and the European maritime policies, although little attention is paid to the quantification of marine ecosystem services in this context. We identify a key challenge of integrating biophysical and socio-economic models as a necessary step to further this research.

  9. An information potential approach for tracking and surveilling multiple moving targets using mobile sensor agents

    Science.gov (United States)

    Lu, W.; Zhang, G.; Ferrari, S.; Fierro, R.; Palunko, I.

    2011-05-01

    The problem of surveilling moving targets using mobile sensor agents (MSAs) is applicable to a variety of fields, including environmental monitoring, security, and manufacturing. Several authors have shown that the performance of a mobile sensor can be greatly improved by planning its motion and control strategies based on its sensing objectives. This paper presents an information potential approach for computing the MSAs' motion plans and control inputs based on the feedback from a modified particle filter used for tracking moving targets. The modified particle filter, as presented in this paper implements a new sampling method (based on supporting intervals of density functions), which accounts for the latest sensor measurements and adapts, accordingly, a mixture representation of the probability density functions (PDFs) for the target motion. It is assumed that the target motion can be modeled as a semi-Markov jump process, and that the PDFs of the Markov parameters can be updated based on real-time sensor measurements by a centralized processing unit or MSAs supervisor. Subsequently, the MSAs supervisor computes an information potential function that is communicated to the sensors, and used to determine their individual feedback control inputs, such that sensors with bounded field-of-view (FOV) can follow and surveil the target over time.

  10. A scenario-based modeling approach for emergency evacuation management and risk analysis under multiple uncertainties.

    Science.gov (United States)

    Lv, Y; Huang, G H; Guo, L; Li, Y P; Dai, C; Wang, X W; Sun, W

    2013-02-15

    Nuclear emergency evacuation is important to prevent radioactive harms by hazardous materials and to limit the accidents' consequences; however, uncertainties are involved in the components and processes of such a management system. In the study, an interval-parameter joint-probabilistic integer programming (IJIP) method is developed for emergency evacuation management under uncertainties. Optimization techniques of interval-parameter programming (IPP) and joint-probabilistic constrained (JPC) programming are incorporated into an integer linear programming framework, so that the approach can deal with uncertainties expressed as joint probability and interval values. The IJIP method can schedule the optimal routes to guarantee the maximum population evacuated away from the effected zone during a finite time. Furthermore, it can also facilitate post optimization analysis to enhance robustness in controlling system violation risk imposed on the joint-probabilistic constraints. The developed method has been applied to a case study of nuclear emergency management; meanwhile, a number of scenarios under different system conditions have been analyzed. It is indicated that the solutions are useful for evacuation management practices. The result of the IJIP method can not only help to raise the capability of disaster responses in a systematic manner, but also provide an insight into complex relationships among evacuation planning, resources utilizations, policy requirements and system risks.

  11. A Multiple Parameters Biodosimetry Tool with Various Blood Cell Counts - the Hemodose Approach

    Science.gov (United States)

    Hu, Shaowen

    2014-01-01

    There continue to be important concerns about the possibility of the occurrence of acute radiation syndromes following nuclear and radiological terrorism or accidents that may result in mass casualties in densely populated areas. To guide medical personnel in their clinical decisions for effective medical management and treatment of the exposed individuals, biological markers are usually applied to examine radiation induced biological changes to assess the severity of radiation injury to sensitive organ systems. Among these the peripheral blood cell counts are widely used to assess the extent of radiation induced bone marrow injury. This is due to the fact that the hematopoietic system is the most vulnerable part of the human body to radiation damage. Particularly, the lymphocyte, granulocyte, and platelet cells are the most radiosensitive of the blood elements, and monitoring their changes after exposure is regarded as a practical and recommended laboratory test to estimate radiation dose and injury. Based upon years of physiological and pathophysiological investigation of mammalian hematopoietic systems, and rigorous coarse-grained bio-mathematical modeling and validation on species from mouse, to dog, monkey, and human, we have developed a set of software tools Hemodose, which can use single or serial granulocyte, lymphocyte, leukocyte, or platelet counts after exposure to estimate absorbed doses of adult victims very rapidly and accurately. Some patient data from historical accidents are utilized as examples to demonstrate the capabilities of these tools as a rapid point-of-care diagnostic or centralized high-throughput assay system in a large-scale radiological disaster scenario. Most significant to the improvement of national and local preparedness of a potential nuclear/radiological disaster, this HemoDose approach establishes robust correlations between the absorbed doses and victim's various types of blood cell counts not only in the early time window (1

  12. Self-reported trait mindfulness and affective reactivity: a motivational approach using multiple psychophysiological measures.

    Directory of Open Access Journals (Sweden)

    Danielle Cosme

    Full Text Available As a form of attention, mindfulness is qualitatively receptive and non-reactive, and is thought to facilitate adaptive emotional responding. One suggested mechanism is that mindfulness facilitates disengagement from an affective stimulus and thereby decreases affective reactivity. However, mindfulness has been conceptualized as a state, intervention, and trait. Because evidence is mixed as to whether self-reported trait mindfulness decreases affective reactivity, we used a multi-method approach to study the relationship between individual differences in self-reported trait mindfulness and electrocortical, electrodermal, electromyographic, and self-reported responses to emotional pictures. Specifically, while participants (N = 51 passively viewed pleasant, neutral, and unpleasant IAPS pictures, we recorded high-density (128 channels electrocortical, electrodermal, and electromyographic data to the pictures as well as to acoustic startle probes presented during the pictures. Afterwards, participants rated their subjective valence and arousal while viewing the pictures again. If trait mindfulness spontaneously reduces general emotional reactivity, then for individuals reporting high rather than low mindfulness, response differences between emotional and neutral pictures would show relatively decreased early posterior negativity (EPN and late positive potential (LPP amplitudes, decreased skin conductance responses, and decreased subjective ratings for valence and arousal. High mindfulness would also be associated with decreased emotional modulation of startle eyeblink and P3 amplitudes. Although results showed clear effects of emotion on the dependent measures, in general, mindfulness did not moderate these effects. For most measures, effect sizes were small with rather narrow confidence intervals. These data do not support the hypothesis that individual differences in self-reported trait mindfulness are related to spontaneous emotional responses

  13. Deterministic approach for multiple-source tsunami hazard assessment for Sines, Portugal

    Science.gov (United States)

    Wronna, M.; Omira, R.; Baptista, M. A.

    2015-11-01

    In this paper, we present a deterministic approach to tsunami hazard assessment for the city and harbour of Sines, Portugal, one of the test sites of project ASTARTE (Assessment, STrategy And Risk Reduction for Tsunamis in Europe). Sines has one of the most important deep-water ports, which has oil-bearing, petrochemical, liquid-bulk, coal, and container terminals. The port and its industrial infrastructures face the ocean southwest towards the main seismogenic sources. This work considers two different seismic zones: the Southwest Iberian Margin and the Gloria Fault. Within these two regions, we selected a total of six scenarios to assess the tsunami impact at the test site. The tsunami simulations are computed using NSWING, a Non-linear Shallow Water model wIth Nested Grids. In this study, the static effect of tides is analysed for three different tidal stages: MLLW (mean lower low water), MSL (mean sea level), and MHHW (mean higher high water). For each scenario, the tsunami hazard is described by maximum values of wave height, flow depth, drawback, maximum inundation area and run-up. Synthetic waveforms are computed at virtual tide gauges at specific locations outside and inside the harbour. The final results describe the impact at the Sines test site considering the single scenarios at mean sea level, the aggregate scenario, and the influence of the tide on the aggregate scenario. The results confirm the composite source of Horseshoe and Marques de Pombal faults as the worst-case scenario, with wave heights of over 10 m, which reach the coast approximately 22 min after the rupture. It dominates the aggregate scenario by about 60 % of the impact area at the test site, considering maximum wave height and maximum flow depth. The HSMPF scenario inundates a total area of 3.5 km2.

  14. Multiple origins of endosymbiosis within the Enterobacteriaceae (γ-Proteobacteria: convergence of complex phylogenetic approaches

    Directory of Open Access Journals (Sweden)

    Husník Filip

    2011-12-01

    Full Text Available Abstract Background The bacterial family Enterobacteriaceae gave rise to a variety of symbiotic forms, from the loosely associated commensals, often designated as secondary (S symbionts, to obligate mutualists, called primary (P symbionts. Determination of the evolutionary processes behind this phenomenon has long been hampered by the unreliability of phylogenetic reconstructions within this group of bacteria. The main reasons have been the absence of sufficient data, the highly derived nature of the symbiont genomes and lack of appropriate phylogenetic methods. Due to the extremely aberrant nature of their DNA, the symbiotic lineages within Enterobacteriaceae form long branches and tend to cluster as a monophyletic group. This state of phylogenetic uncertainty is now improving with an increasing number of complete bacterial genomes and development of new methods. In this study, we address the monophyly versus polyphyly of enterobacterial symbionts by exploring a multigene matrix within a complex phylogenetic framework. Results We assembled the richest taxon sampling of Enterobacteriaceae to date (50 taxa, 69 orthologous genes with no missing data and analyzed both nucleic and amino acid data sets using several probabilistic methods. We particularly focused on the long-branch attraction-reducing methods, such as a nucleotide and amino acid data recoding and exclusion (including our new approach and slow-fast analysis, taxa exclusion and usage of complex evolutionary models, such as nonhomogeneous model and models accounting for site-specific features of protein evolution (CAT and CAT+GTR. Our data strongly suggest independent origins of four symbiotic clusters; the first is formed by Hamiltonella and Regiella (S-symbionts placed as a sister clade to Yersinia, the second comprises Arsenophonus and Riesia (S- and P-symbionts as a sister clade to Proteus, the third Sodalis, Baumannia, Blochmannia and Wigglesworthia (S- and P-symbionts as a sister

  15. A Personalized Approach in Progressive Multiple Sclerosis: The Current Status of Disease Modifying Therapies (DMTs and Future Perspectives

    Directory of Open Access Journals (Sweden)

    Emanuele D’Amico

    2016-10-01

    Full Text Available Using the term of progressive multiple sclerosis (PMS, we considered a combined population of persons with secondary progressive MS (SPMS and primary progressive MS (PPMS. These forms of MS cannot be challenged with efficacy by the licensed therapy. In the last years, several measures of risk estimation were developed for predicting clinical course in MS, but none is specific for the PMS forms. Personalized medicine is a therapeutic approach, based on identifying what might be the best therapy for an individual patient, taking into account the risk profile. We need to achieve more accurate estimates of useful predictors in PMS, including unconventional and qualitative markers which are not yet currently available or practicable routine diagnostics. The evaluation of an individual patient is based on the profile of disease activity.Within the neurology field, PMS is one of the fastest-moving going into the future.

  16. Cellular Approach to Long-Range $p_t$ and Multiplicity Correlations in the String Fusion Model

    CERN Document Server

    Vechernin, V V

    2003-01-01

    The long-range $p_t$ and multiplicity($n$) correlations in high-energy nuclear collisions are studied in the framework of a simple cellular analog of the string fusion model. Two cases with local and global string fusion is considered. The $p_t$--$n$ and $n$--$n$ correlation functions and correlation coefficients are calculated analytically in some asymptotic cases using suggested Gauss approximation. It's shown that at large string density the $p_t$--$n$ and $n$--$n$ correlation coefficients are connected and the scaling takes place. The behavior of the correlations at small string density is also studied. The asymptotic results are compared with results of the numerical calculations in the framework of proposed cellular approach.

  17. A Personalized Approach in Progressive Multiple Sclerosis: The Current Status of Disease Modifying Therapies (DMTs) and Future Perspectives

    Science.gov (United States)

    D’Amico, Emanuele; Patti, Francesco; Zanghì, Aurora; Zappia, Mario

    2016-01-01

    Using the term of progressive multiple sclerosis (PMS), we considered a combined population of persons with secondary progressive MS (SPMS) and primary progressive MS (PPMS). These forms of MS cannot be challenged with efficacy by the licensed therapy. In the last years, several measures of risk estimation were developed for predicting clinical course in MS, but none is specific for the PMS forms. Personalized medicine is a therapeutic approach, based on identifying what might be the best therapy for an individual patient, taking into account the risk profile. We need to achieve more accurate estimates of useful predictors in PMS, including unconventional and qualitative markers which are not yet currently available or practicable routine diagnostics. The evaluation of an individual patient is based on the profile of disease activity.Within the neurology field, PMS is one of the fastest-moving going into the future. PMID:27763513

  18. Some experiments with a savings heuristic and a tabu search approach for the vehicle routing problem with multiple deliverymen

    Directory of Open Access Journals (Sweden)

    Vanessa de Oliveira Ferreira

    2012-08-01

    Full Text Available In this work we consider a variant of the vehicle routing problem that allows the assignment of multiple deliverymen to one or more routes. A practical motivation for this variant arises, for example, in the distribution of beverages in highly dense urban areas, characterized by the difficulty in serving daily requests within regular working day hours with a single deliveryman per vehicle. We present a mathematical model and a savings algorithm in order to generate low cost routes that maximize the number of requests served in compliance with the maximum route time. The impact of the extra deliverymen on the solutions provided by the proposed heuristic is assessed by means of sets of generated examples based on classical instances of literature. It is also presented the results obtained by an adaptation of a tabu search approach from the literature.

  19. WebMOTIFS: automated discovery, filtering and scoring of DNA sequence motifs using multiple programs and Bayesian approaches.

    Science.gov (United States)

    Romer, Katherine A; Kayombya, Guy-Richard; Fraenkel, Ernest

    2007-07-01

    WebMOTIFS provides a web interface that facilitates the discovery and analysis of DNA-sequence motifs. Several studies have shown that the accuracy of motif discovery can be significantly improved by using multiple de novo motif discovery programs and using randomized control calculations to identify the most significant motifs or by using Bayesian approaches. WebMOTIFS makes it easy to apply these strategies. Using a single submission form, users can run several motif discovery programs and score, cluster and visualize the results. In addition, the Bayesian motif discovery program THEME can be used to determine the class of transcription factors that is most likely to regulate a set of sequences. Input can be provided as a list of gene or probe identifiers. Used with the default settings, WebMOTIFS accurately identifies biologically relevant motifs from diverse data in several species. WebMOTIFS is freely available at http://fraenkel.mit.edu/webmotifs.

  20. Effects of long-term differential fertilization on eukaryotic microbial communities in an arable soil: a multiple barcoding approach.

    Science.gov (United States)

    Lentendu, Guillaume; Wubet, Tesfaye; Chatzinotas, Antonis; Wilhelm, Christian; Buscot, François; Schlegel, Martin

    2014-07-01

    To understand the fine-scale effects of changes in nutrient availability on eukaryotic soil microorganisms communities, a multiple barcoding approach was used to analyse soil samples from four different treatments in a long-term fertilization experiment. We performed PCR amplification on soil DNA with primer pairs specifically targeting the 18S rRNA genes of all eukaryotes and three protist groups (Cercozoa, Chrysophyceae-Synurophyceae and Kinetoplastida) as well as the ITS gene of fungi and the 23S plastid rRNA gene of photoautotrophic microorganisms. Amplicons were pyrosequenced, and a total of 88,706 quality filtered reads were clustered into 1232 operational taxonomic units (OTU) across the six data sets. Comparisons of the taxonomic coverage achieved based on overlapping assignment of OTUs revealed that half of the eukaryotic taxa identified were missed by the universal eukaryotic barcoding marker. There were only little differences in OTU richness observed between organic- (farmyard manure), mineral- and nonfertilized soils. However, the community compositions appeared to be strongly structured by organic fertilization in all data sets other than that generated using the universal eukaryotic 18S rRNA gene primers, whereas mineral fertilization had only a minor effect. In addition, a co-occurrence based network analysis revealed complex potential interaction patterns between OTUs from different trophic levels, for example between fungivorous flagellates and fungi. Our results demonstrate that changes in pH, moisture and organic nutrients availability caused shifts in the composition of eukaryotic microbial communities at multiple trophic levels.

  1. A new breast cancer risk analysis approach using features extracted from multiple sub-regions on bilateral mammograms

    Science.gov (United States)

    Sun, Wenqing; Tseng, Tzu-Liang B.; Zheng, Bin; Zhang, Jianying; Qian, Wei

    2015-03-01

    A novel breast cancer risk analysis approach is proposed for enhancing performance of computerized breast cancer risk analysis using bilateral mammograms. Based on the intensity of breast area, five different sub-regions were acquired from one mammogram, and bilateral features were extracted from every sub-region. Our dataset includes 180 bilateral mammograms from 180 women who underwent routine screening examinations, all interpreted as negative and not recalled by the radiologists during the original screening procedures. A computerized breast cancer risk analysis scheme using four image processing modules, including sub-region segmentation, bilateral feature extraction, feature selection, and classification was designed to detect and compute image feature asymmetry between the left and right breasts imaged on the mammograms. The highest computed area under the curve (AUC) is 0.763 ± 0.021 when applying the multiple sub-region features to our testing dataset. The positive predictive value and the negative predictive value were 0.60 and 0.73, respectively. The study demonstrates that (1) features extracted from multiple sub-regions can improve the performance of our scheme compared to using features from whole breast area only; (2) a classifier using asymmetry bilateral features can effectively predict breast cancer risk; (3) incorporating texture and morphological features with density features can boost the classification accuracy.

  2. Numerical Evaluation and Optimization of Multiple Hydraulically Fractured Parameters Using a Flow-Stress-Damage Coupled Approach

    Directory of Open Access Journals (Sweden)

    Yu Wang

    2016-04-01

    Full Text Available Multiple-factor analysis and optimization play a critical role in the the ability to maximizethe stimulated reservoir volume (SRV and the success of economic shale gas production. In this paper, taking the typical continental naturally fractured silty laminae shale in China as anexample, response surface methodology (RSM was employed to optimize multiple hydraulic fracturing parameters to maximize the stimulated area in combination with numerical modeling based on the coupled flow-stress-damage (FSD approach. This paper demonstrates hydraulic fracturing effectiveness by defining two indicesnamelythe stimulated reservoir area (SRA and stimulated silty laminae area (SLA. Seven uncertain parameters, such as laminae thickness, spacing, dip angle, cohesion, internal friction angle (IFA, in situ stress difference (SD, and an operational parameter-injection rate (IR with a reasonable range based on silty Laminae Shale, Southeastern Ordos Basin, are used to fit a response of SRA and SLA as the objective function, and finally identity the optimum design under the parameters based on simultaneously maximizingSRA and SLA. In addition, asensitivity analysis of the influential factors is conducted for SRA and SLA. The aim of the study is to improve the artificial ability to control the fracturing network by means of multi-parameteroptimization. This work promises to provide insights into the effective exploitation of unconventional shale gas reservoirs via optimization of the fracturing design for continental shale, Southeastern Ordos Basin, China.

  3. A possibilistic programming approach for the location problem of multiple cross-docks and vehicle routing scheduling under uncertainty

    Science.gov (United States)

    Meysam Mousavi, S.; Tavakkoli-Moghaddam, Reza; Jolai, Fariborz

    2013-10-01

    This article considers the design of cross-docking systems under uncertainty in a model that consists of two phases: (1) a strategic-based decision-making process for selecting the location of cross-docks to operate, and (2) an operational-based decision-making process for vehicle routing scheduling with multiple cross-docks. This logistic system contains three echelons, namely suppliers, cross-docks and retailers, in an uncertain environment. In the first phase, a new multi-period cross-dock location model is introduced to determine the minimum number of cross-docks among a set of location sites so that each retailer demand should be met. Then, in the second phase, a new vehicle routing scheduling model with multiple cross-docks is formulated in which each vehicle is able to pickup from or deliver to more than one supplier or retailer, and the pickup and delivery routes start and end at the corresponding cross-dock. This article is the first attempt to introduce an integrated model for cross-docking systems design under a fuzzy environment. To solve the presented two-phase mixed-integer programming (MIP) model, a new fuzzy mathematical programming-based possibilistic approach is used. Furthermore, experimental tests are carried out to demonstrate the effectiveness of the presented model. The computational results reveal the applicability and suitability of the developed fuzzy possibilistic two-phase model in a variety of problems in the domain of cross-docking systems.

  4. A heuristic optimization approach for Air Quality Monitoring Network design with the simultaneous consideration of multiple pollutants.

    Science.gov (United States)

    Elkamel, A; Fatehifar, E; Taheri, M; Al-Rashidi, M S; Lohi, A

    2008-08-01

    An interactive optimization methodology for allocating the number and configuration of an Air Quality Monitoring Network (AQMN) in a vast area to identify the impact of multiple pollutants is described. A mathematical model based on the multiple cell approach (MCA) was used to create monthly spatial distributions for the concentrations of the pollutants emitted from different emission sources. These spatial temporal patterns were subject to a heuristic optimization algorithm to identify the optimal configuration of a monitoring network. The objective of the optimization is to provide maximum information about multi-pollutants (i.e., CO, NO(x) and SO(2)) emitted from each source within a given area. The model was applied to a network of existing refinery stacks and the results indicate that three stations can provide a total coverage of more than 70%. In addition, the effect of the spatial correlation coefficient (R(C)) on total area coverage was analyzed. The modeling results show that as the cutoff correlation coefficient R(C) is increased from 0.75 to 0.95, the number of monitoring stations required for total coverage is increased. A high R(C) based network may not necessarily cover the entire region, but the covered region will be well represented. A low R(C) based network, on the other hand, would offer more coverage of the region, but the covered region may not be satisfactorily represented.

  5. Quantifying Forest Spatial Pattern Trends at Multiple Extents: An Approach to Detect Significant Changes at Different Scales

    Directory of Open Access Journals (Sweden)

    Ludovico Frate

    2014-09-01

    Full Text Available We propose a procedure to detect significant changes in forest spatial patterns and relevant scales. Our approach consists of four sequential steps. First, based on a series of multi-temporal forest maps, a set of geographic windows of increasing extents are extracted. Second, for each extent and date, specific stochastic simulations that replicate real-world spatial pattern characteristics are run. Third, by computing pattern metrics on both simulated and real maps, their empirical distributions and confidence intervals are derived. Finally, multi-temporal scalograms are built for each metric. Based on cover maps (1954, 2011 with a resolution of 10 m we analyze forest pattern changes in a central Apennines (Italy reserve at multiple spatial extents (128, 256 and 512 pixels. We identify three types of multi-temporal scalograms, depending on pattern metric behaviors, describing different dynamics of natural reforestation process. The statistical distribution and variability of pattern metrics at multiple extents offers a new and powerful tool to detect forest variations over time. Similar procedures can (i help to identify significant changes in spatial patterns and provide the bases to relate them to landscape processes; (ii minimize the bias when comparing pattern metrics at a single extent and (iii be extended to other landscapes and scales.

  6. The effects of intracranial volume adjustment approaches on multiple regional MRI volumes in healthy aging and Alzheimer’s disease

    Directory of Open Access Journals (Sweden)

    Olga eVoevodskaya

    2014-10-01

    Full Text Available In neurodegeneration research, normalization of regional volumes by intracranial volume (ICV is important to estimate the extent of disease-driven atrophy. There is little agreement as to whether raw volumes, volume-to-ICV fractions or regional volumes from which the ICV factor has been regressed out should be used for volumetric brain imaging studies. Using multiple regional cortical and subcortical volumetric measures generated by Freesurfer (51 in total, the main aim of this study was to elucidate the implications of these adjustment approaches. Magnetic resonance imaging (MRI data were analyzed from two large cohorts, the population-based PIVUS cohort (N=406, all subjects age 75 and the Alzheimer disease Neuroimaging Initiative (ADNI cohort (N=724. Further, we studied whether the chosen ICV normalization approach influenced the relationship between hippocampus and cognition in the three diagnostic groups of the ADNI cohort (Alzheimer’s disease, mild cognitive impairment and healthy individuals. The ability of raw vs adjusted hippocampal volumes to predict diagnostic status was also assessed. In both cohorts raw volumes correlate positively with ICV, but do not scale directly proportionally with it. The correlation direction is reversed for all volume-to-ICV fractions, except the lateral and third ventricles. Most grey matter fractions are larger in females, while lateral ventricle fractions are greater in males. Residual correction effectively eliminated the correlation between the regional volumes and ICV and removed gender differences. The association between hippocampal volumes and cognition was not altered by ICV normalization. Comparing prediction of diagnostic status using the different approaches, small but significant differences were found. The choice of normalization approach should be carefully considered when designing a volumetric brain imaging study.

  7. A decision analysis approach to climate adaptation: comparing multiple pathways for multi-decadal decision making

    Science.gov (United States)

    Lin, B. B.; Little, L.

    2013-12-01

    Policy planners around the world are required to consider the implications of adapting to climatic change across spatial contexts and decadal timeframes. However, local level information for planning is often poorly defined, even though climate adaptation decision-making is made at this scale. This is especially true when considering sea level rise and coastal impacts of climate change. We present a simple approach using sea level rise simulations paired with adaptation scenarios to assess a range of adaptation options available to local councils dealing with issues of beach recession under present and future sea level rise and storm surge. Erosion and beach recession pose a large socioeconomic risk to coastal communities because of the loss of key coastal infrastructure. We examine the well-known adaptation technique of beach nourishment and assess various timings and amounts of beach nourishment at decadal time spans in relation to beach recession impacts. The objective was to identify an adaptation strategy that would allow for a low frequency of management interventions, the maintenance of beach width, and the ability to minimize variation in beach width over the 2010 to 2100 simulation period. 1000 replications of each adaptation option were produced against the 90 year simulation in order to model the ability each adaptation option to achieve the three key objectives. Three sets of adaptation scenarios were identified. Within each scenario, a number of adaptation options were tested. The three scenarios were: 1) Fixed periodic beach replenishment of specific amounts at 20 and 50 year intervals, 2) Beach replenishment to the initial beach width based on trigger levels of recession (5m, 10m, 20m), and 3) Fixed period beach replenishment of a variable amount at decadal intervals (every 10, 20, 30, 40, 50 years). For each adaptation option, we show the effectiveness of each beach replenishment scenario to maintain beach width and consider the implications of more

  8. Desempeño mnésico y funciones ejecutivas en pacientes con esclerosis múltiple (EM

    Directory of Open Access Journals (Sweden)

    Fernanda López-Ramón

    2008-12-01

    Full Text Available The Episodic Memory (EM and the Executive Functions (EF are cognitive areas that are affected in patients with diagnosis of Multiple Sclerosis (MS. Nowadays there exists scarce works destined to explore the influence of the EF on measures of mnesic performance in MS. For this reason, we analyze the effect of the EF on the performance in a set of memory measures. We worked with a clinical group (n=36 and with a control group (n=36 compared by age and educational level. The results show that the clinical group obtained significantly low average values in all the mnesic indexes (with exception of recognition and in all the executive measures. All the executive indexes showed significant associations with some of the indexes of mnesic performance. These findings suggest that the problems in the episodic memory in EM patients could be analyzed as the manifestation of a global disorder that could be similar to the one that involves the EF.

  9. Neuropsychological syndromes in multiple sclerosis

    OpenAIRE

    Gil Moreno, Mª José; Cerezo García, Marta; Marasescu, Raluca; Pinel González, Ana; López Álvarez, Laudino; Aladro Benito, Yolanda

    2013-01-01

    Síndromes neuropsicológicos en la esclerosis múltiple. Antecedentes: entre el 45-65% de los pacientes con esclerosis múltiple (EM) manifiestan déficits cognitivos en velocidad de procesamiento de la información (VPI), atención, memoria, funciones ejecutivas (FE) y visuoconstrucción. La alteración del lenguaje y la gnosis visual es infrecuente y poco reconocida. El objetivo es la descripción cognitiva, clínica y radiológica de cinco pacientes con EM con síndromes neuropsicológicos (SNPS). Méto...

  10. An Alternative Humans to Mars Approach: Reducing Mission Mass with Multiple Mars Flyby Trajectories and Minimal Capability Investments

    Science.gov (United States)

    Whitley, Ryan J.; Jedrey, Richard; Landau, Damon; Ocampo, Cesar

    2015-01-01

    Mars flyby trajectories and Earth return trajectories have the potential to enable lower- cost and sustainable human exploration of Mars. Flyby and return trajectories are true minimum energy paths with low to zero post-Earth departure maneuvers. By emplacing the large crew vehicles required for human transit on these paths, the total fuel cost can be reduced. The traditional full-up repeating Earth-Mars-Earth cycler concept requires significant infrastructure, but a Mars only flyby approach minimizes mission mass and maximizes opportunities to build-up missions in a stepwise manner. In this paper multiple strategies for sending a crew of 4 to Mars orbit and back are examined. With pre-emplaced assets in Mars orbit, a transit habitat and a minimally functional Mars taxi, a complete Mars mission can be accomplished in 3 SLS launches and 2 Mars Flyby's, including Orion. While some years are better than others, ample opportunities exist within a given 15-year Earth-Mars alignment cycle. Building up a mission cadence over time, this approach can translate to Mars surface access. Risk reduction, which is always a concern for human missions, is mitigated by the use of flybys with Earth return (some of which are true free returns) capability.

  11. Identification of novel adhesins of M. tuberculosis H37Rv using integrated approach of multiple computational algorithms and experimental analysis.

    Science.gov (United States)

    Kumar, Sanjiv; Puniya, Bhanwar Lal; Parween, Shahila; Nahar, Pradip; Ramachandran, Srinivasan

    2013-01-01

    Pathogenic bacteria interacting with eukaryotic host express adhesins on their surface. These adhesins aid in bacterial attachment to the host cell receptors during colonization. A few adhesins such as Heparin binding hemagglutinin adhesin (HBHA), Apa, Malate Synthase of M. tuberculosis have been identified using specific experimental interaction models based on the biological knowledge of the pathogen. In the present work, we carried out computational screening for adhesins of M. tuberculosis. We used an integrated computational approach using SPAAN for predicting adhesins, PSORTb, SubLoc and LocTree for extracellular localization, and BLAST for verifying non-similarity to human proteins. These steps are among the first of reverse vaccinology. Multiple claims and attacks from different algorithms were processed through argumentative approach. Additional filtration criteria included selection for proteins with low molecular weights and absence of literature reports. We examined binding potential of the selected proteins using an image based ELISA. The protein Rv2599 (membrane protein) binds to human fibronectin, laminin and collagen. Rv3717 (N-acetylmuramoyl-L-alanine amidase) and Rv0309 (L,D-transpeptidase) bind to fibronectin and laminin. We report Rv2599 (membrane protein), Rv0309 and Rv3717 as novel adhesins of M. tuberculosis H37Rv. Our results expand the number of known adhesins of M. tuberculosis and suggest their regulated expression in different stages.

  12. Identification of novel adhesins of M. tuberculosis H37Rv using integrated approach of multiple computational algorithms and experimental analysis.

    Directory of Open Access Journals (Sweden)

    Sanjiv Kumar

    Full Text Available Pathogenic bacteria interacting with eukaryotic host express adhesins on their surface. These adhesins aid in bacterial attachment to the host cell receptors during colonization. A few adhesins such as Heparin binding hemagglutinin adhesin (HBHA, Apa, Malate Synthase of M. tuberculosis have been identified using specific experimental interaction models based on the biological knowledge of the pathogen. In the present work, we carried out computational screening for adhesins of M. tuberculosis. We used an integrated computational approach using SPAAN for predicting adhesins, PSORTb, SubLoc and LocTree for extracellular localization, and BLAST for verifying non-similarity to human proteins. These steps are among the first of reverse vaccinology. Multiple claims and attacks from different algorithms were processed through argumentative approach. Additional filtration criteria included selection for proteins with low molecular weights and absence of literature reports. We examined binding potential of the selected proteins using an image based ELISA. The protein Rv2599 (membrane protein binds to human fibronectin, laminin and collagen. Rv3717 (N-acetylmuramoyl-L-alanine amidase and Rv0309 (L,D-transpeptidase bind to fibronectin and laminin. We report Rv2599 (membrane protein, Rv0309 and Rv3717 as novel adhesins of M. tuberculosis H37Rv. Our results expand the number of known adhesins of M. tuberculosis and suggest their regulated expression in different stages.

  13. White matter cysts in patients with tuberous sclerosis; Quistes de sustancia blanca en pacientes con esclerosis tuberosa

    Energy Technology Data Exchange (ETDEWEB)

    Marti-Bonmati, L.; Dosda, R. [Hospital Universitario Dr. Peset. Servicio de Resonancia Magnetica ATQ-Quiron. Valencia (Spain); Menor, F. [Hospital Infantil La Fe. Valencia (Spain); Arana, E. [Hospital Casa de La Salud. Valencia (Spain); Poyatos, C. [Hospital Universitario Dr. Peset. Valencia (Spain)

    1999-07-01

    The presence of cysts in the white matter of the central nervous system of patients with tuberous sclerosis (TS) is an uncommon finding that has been reported only recently in neuroimaging studies. This article assesses the prevalence of these lesions in a large series of patients studied by magnetic resonance imaging (MRI) and their relationship to other epidemiological and imaging findings. MRI studies were performed in 46 patients (23 males and 23 females) with a mean age of 12.7 years, and the results were examined retrospectively in the search for cortical tubers, subependymal nodules and white matter nodules, lines and cysts. Nine patients (19.6%) presented cysts in white matter. Seven had only one cyst and the remaining two patients each had two. Multiple regression analysis relating the presence of the cysts with other neuroimaging findings in these patients revealed a statistically significant relationship only with white matter nodules (odds ratio: 7.5; p=0.006). White matter cysts are small, supratentorial lesions of deep location. There is a statistically relationship between the presence of these cysts and that of nodular lesions in the white matter. This finding supports the theory that the cyst originate from white matter nodules. (Author) 17 refs.

  14. Acceleration of Ab Initio QM/MM Calculations under Periodic Boundary Conditions by Multiscale and Multiple Time Step Approaches.

    Science.gov (United States)

    Nam, Kwangho

    2014-10-14

    Development of multiscale ab initio quantum mechanical and molecular mechanical (AI-QM/MM) method for periodic boundary molecular dynamics (MD) simulations and their acceleration by multiple time step approach are described. The developed method achieves accuracy and efficiency by integrating the AI-QM/MM level of theory and the previously developed semiempirical (SE) QM/MM-Ewald sum method [J. Chem. Theory Comput. 2005, 1, 2] extended to the smooth particle-mesh Ewald (PME) summation method. In the developed methods, the total energy of the simulated system is evaluated at the SE-QM/MM-PME level of theory to include long-range QM/MM electrostatic interactions, which is then corrected on the fly using the AI-QM/MM level of theory within the real space cutoff. The resulting energy expression enables decomposition of total forces applied to each atom into forces determined at the low-level SE-QM/MM method and correction forces at the AI-QM/MM level, to integrate the system using the reversible reference system propagator algorithm. The resulting method achieves a substantial speed-up of the entire calculation by minimizing the number of time-consuming energy and gradient evaluations at the AI-QM/MM level. Test calculations show that the developed multiple time step AI-QM/MM method yields MD trajectories and potential of mean force profiles comparable to single time step QM/MM results. The developed method, together with message passing interface (MPI) parallelization, accelerates the present AI-QM/MM MD simulations about 30-fold relative to the speed of single-core AI-QM/MM simulations for the molecular systems tested in the present work, making the method less than one order slower than the SE-QM/MM methods under periodic boundary conditions.

  15. Estudio clínico y de resonancia magnética del rendimiento cognitivo en síndromes neurológicos aislados sugestivos de esclerosis múltiple

    OpenAIRE

    Arévalo Navinés, María Jesús

    2014-01-01

    Introducció: Històricament, encara que la presència d’alteracions cognitives en l’esclerosi múltiple (EM) ja va ser descrita per Charcot a finals del segle XIX, no ha estat fins fa pocs anys que ha cobrat especial rellevància. S’estima una freqüència del 40-60% de disfunció cognitiva en la població general que pateix aquesta malaltia i, més recentment, d’aproximadament el 27-57%, en pacients amb síndromes neurològics aïllats (SNA), segons diferents criteris de referència. Els objectius del pr...

  16. Estudios de resonancia magnética y técnicas electrofisiológicas para evaluar y predecir la discapacidad en pacientes con esclerosis múltiple

    OpenAIRE

    Llufriu Duran, Sara

    2013-01-01

    [spa] La presente tesis se basa en cuatro artículos originales y un artículo de revisión que pertenecen a una misma línea de trabajo: el uso de técnicas de resonancia magnética (RM) y electrofisiológicas para evaluar y predecir la discapacidad física o cognitiva en pacientes con esclerosis múltiple (EM). En primer lugar, a través de RM convencional se ha evaluado el comportamiento radiológico de determinados patrones de lesiones cerebrales y su asociación con una peor evolución de la discapac...

  17. Influencia de las hormonas sexuales en mujeres con esclerosis múltiple durante la memoria de trabajo y la activación cerebral medida con mapeo electroencefalográfico

    Directory of Open Access Journals (Sweden)

    Marisol Silva

    2012-07-01

    Full Text Available La Esclerosis Múltiple es una enfermedad inflamatoria desmielinizante del Sistema Nervioso Central, que se presenta con más frecuencia en mujeres, lo cual sugiere que las hormonas sexuales parecen modular la manifestación de la sintomatología. La actividad electroencefalografíca no ha sido evaluada en mujeres con Esclerosis Múltiple durante el procesamiento de Memoria de Trabajo y su estado hormonal. Los registros se realizaron en las fases folicular y lútea del ciclo menstrual de manera simultánea la tarea cognitiva y el electroencefalograma, además se correlacionaron con los niveles hormonales. La fase lútea mostró una ejecución mejor con un mayor número de categorías alcanzadas (p<0.004, un menor número de errores perseverativos (p<0.003 y un mayor número de ensayos para alcanzar una categoría (p<0.011, se asoció con un aumento de la actividad de Theta (p<0.018 y Alfa 2 (p<0.000. El 92% de la variabilidad en el número de ensayos de la tarea, fue explicada por la actividad de Theta y Alfa 2, Hormona Luteinizante y Estrona en la fase folicular, en la fase lútea el 90% de la variabilidad fue explicada por la actividad de Theta, Hormona Luteinizante, Progesterona y Estradiol. La Memoria de trabajo mejora en la fase lútea del ciclo menstrual, sugiriendo que la progesterona parece facilitar actividad de Theta.

  18. Population Balance Modeling of Polydispersed Bubbly Flow in Continuous-Casting Using Multiple-Size-Group Approach

    Science.gov (United States)

    Liu, Zhongqiu; Li, Linmin; Qi, Fengsheng; Li, Baokuan; Jiang, Maofa; Tsukihashi, Fumitaka

    2015-02-01

    A population balance model based on the multiple-size-group (MUSIG) approach has been developed to investigate the polydispersed bubbly flow inside the slab continuous-casting mold and bubble behavior including volume fraction, breakup, coalescence, and size distribution. The Eulerian-Eulerian approach is used to describe the equations of motion of the two-phase flow. All the non-drag forces (lift force, virtual mass force, wall lubrication force, and turbulent dispersion force) and drag force are incorporated in this model. Sato and Sekiguchi model is used to account for the bubble-induced turbulence. Luo and Svendsen model and Prince and Blanch model are used to describe the bubbles breakup and coalescence behavior, respectively. A 1/4th water model of the slab continuous-casting mold was applied to investigate the distribution and size of bubbles by injecting air through a circumferential inlet chamber which was made of the specially-coated samples of mullite porous brick, which is used for the actual upper nozzle. Against experimental data, numerical results showed good agreement for the gas volume fraction and local bubble Sauter mean diameter. The bubble Sauter mean diameter in the upper recirculation zone decreases with increasing water flow rate and increases with increasing gas flow rate. The distribution of bubble Sauter mean diameter along the width direction of the upper mold increases first, and then gradually decreases from the SEN to the narrow wall. Close agreements between the predictions and measurements demonstrate the capability of the MUSIG model in modeling bubbly flow inside the continuous-casting mold.

  19. [Consensus document on spasticity in patients with multiple sclerosis. Grupo de Enfermedades Desmielinizantes de la Sociedad Española de Neurología].

    Science.gov (United States)

    Oreja-Guevara, Celia; Montalban, Xavier; de Andrés, Clara; Casanova-Estruch, Bonaventura; Muñoz-García, Delicias; García, Inmaculada; Fernández, Óscar

    2013-10-16

    Introduccion. La esclerosis multiple es una enfermedad neurologica cronica, desmielinizante e inflamatoria. Los neurologos implicados en el tratamiento sintomatico de esta enfermedad tienden a aplicar criterios diagnosticos y de tratamiento heterogeneos. Objetivo. Elaborar un documento de consenso para establecer criterios homogeneos para el tratamiento de la espasticidad, basados en el conocimiento cientifico disponible que faciliten la toma de decisiones en la practica clinica habitual. Desarrollo. Un grupo de expertos españoles en esclerosis multiple del Grupo de Enfermedades Desmielinizantes de la Sociedad Española de Neurologia (SEN) se reunieron para revisar los aspectos relacionados con la espasticidad en esta enfermedad y elaborar el consenso. Tras una busqueda bibliografica exhaustiva y siguiendo la metodologia metaplan se establecieron unas recomendaciones preliminares para incorporar al documento. Finalmente, cada argumento se clasifico segun su grado de recomendacion, atendiendo a las categorias del sistema SIGN (Scottish Intercollegiate Guidelines Network). El texto resultante fue sometido a la revision de los miembros del Grupo de Enfermedades Desmielinizantes de la SEN. Se ha alcanzado un consenso de expertos respecto a los factores desencadenantes de la espasticidad, la sintomatologia relacionada, los criterios diagnosticos, los metodos de valoracion de la espasticidad, la calidad de vida y los criterios en el manejo terapeutico (farmacologicos y no farmacologicos). Conclusion. Las recomendaciones contenidas en este consenso pueden ser una herramienta util para el neurologo para la practica clinica del dia a dia y para mejorar la calidad de vida del paciente, ya que permiten un mejor diagnostico y tratamiento de la espasticidad.

  20. A coupled wave-3-D hydrodynamics model of the Taranto Sea (Italy): a multiple-nesting approach

    Science.gov (United States)

    Gaeta, Maria Gabriella; Samaras, Achilleas G.; Federico, Ivan; Archetti, Renata; Maicu, Francesco; Lorenzetti, Giuliano

    2016-09-01

    The present work describes an operational strategy for the development of a multiscale modeling system, based on a multiple-nesting approach and open-source numerical models. The strategy was applied and validated for the Gulf of Taranto in southern Italy, scaling large-scale oceanographic model results to high-resolution coupled wave-3-D hydrodynamics simulations for the area of Mar Grande in the Taranto Sea. The spatial and temporal high-resolution simulations were performed using the open-source TELEMAC suite, forced by wind data from the COSMO-ME database, boundary wave spectra from the RON buoy at Crotone and results from the Southern Adriatic Northern Ionian coastal Forecasting System (SANIFS) regarding sea levels and current fields. Model validation was carried out using data collected in the Mar Grande basin from a fixed monitoring station and during an oceanographic campaign in October 2014. The overall agreement between measurements and model results in terms of waves, sea levels, surface currents, circulation patterns and vertical velocity profiles is deemed to be satisfactory, and the methodology followed in the process can constitute a useful tool for both research and operational applications in the same field and as support of decisions for management and design of infrastructures.

  1. Longitudinal gradient coils with enhanced radial uniformity in restricted diameter: Single-current and multiple-current approaches

    Science.gov (United States)

    Romero, Javier A.; Domínguez, Gabriela A.; Anoardo, Esteban

    2017-03-01

    An important requirement for a gradient coil is that the uniformity of the generated magnetic field gradient should be maximal within the active volume of the coil. For a cylindrical geometry, the radial uniformity of the gradient turns critic, particularly in cases where the gradient-unit has to be designed to fit into the inner bore of a compact magnet of reduced dimensions, like those typically used in fast-field-cycling NMR. In this paper we present two practical solutions aimed to fulfill this requirement. We propose a matrix-inversion optimization algorithm based on the Biot-Savart law, that using a proper cost function, allows maximizing the uniformity of the gradient and power efficiency. The used methodology and the simulation code were validated in a single-current design, by comparing the computer simulated field map with the experimental data measured in a real prototype. After comparing the obtained results with the target field approach, a multiple-element coil driven by independent current sources is discussed, and a real prototype evaluated. Opposed equispaced independent windings are connected in pairs conforming an arrangement of independent anti-Helmholtz units. This last coil seizes 80% of its radial dimension with a gradient uniformity better than 5%. The design also provides an adaptable region of uniformity along with adjustable coil efficiency.

  2. Estimation of source location and ground impedance using a hybrid multiple signal classification and Levenberg-Marquardt approach

    Science.gov (United States)

    Tam, Kai-Chung; Lau, Siu-Kit; Tang, Shiu-Keung

    2016-07-01

    A microphone array signal processing method for locating a stationary point source over a locally reactive ground and for estimating ground impedance is examined in detail in the present study. A non-linear least square approach using the Levenberg-Marquardt method is proposed to overcome the problem of unknown ground impedance. The multiple signal classification method (MUSIC) is used to give the initial estimation of the source location, while the technique of forward backward spatial smoothing is adopted as a pre-processer of the source localization to minimize the effects of source coherence. The accuracy and robustness of the proposed signal processing method are examined. Results show that source localization in the horizontal direction by MUSIC is satisfactory. However, source coherence reduces drastically the accuracy in estimating the source height. The further application of Levenberg-Marquardt method with the results from MUSIC as the initial inputs improves significantly the accuracy of source height estimation. The present proposed method provides effective and robust estimation of the ground surface impedance.

  3. Prediction of Currency Volume Issued in Taiwan Using a Hybrid Artificial Neural Network and Multiple Regression Approach

    Directory of Open Access Journals (Sweden)

    Yuehjen E. Shao

    2013-01-01

    Full Text Available Because the volume of currency issued by a country always affects its interest rate, price index, income levels, and many other important macroeconomic variables, the prediction of currency volume issued has attracted considerable attention in recent years. In contrast to the typical single-stage forecast model, this study proposes a hybrid forecasting approach to predict the volume of currency issued in Taiwan. The proposed hybrid models consist of artificial neural network (ANN and multiple regression (MR components. The MR component of the hybrid models is established for a selection of fewer explanatory variables, wherein the selected variables are of higher importance. The ANN component is then designed to generate forecasts based on those important explanatory variables. Subsequently, the model is used to analyze a real dataset of Taiwan's currency from 1996 to 2011 and twenty associated explanatory variables. The prediction results reveal that the proposed hybrid scheme exhibits superior forecasting performance for predicting the volume of currency issued in Taiwan.

  4. Fuzzy Analytical Hierarchical Process and Spatially Explicit Uncertainty Analysis Approach for Multiple Forest Fire Risk Mapping. GI_Forum|GI_Forum 2015 – Geospatial Minds for Society|

    OpenAIRE

    2016-01-01

    Uncertainty is associated with GIS- Multi Criteria Decision Analysis (GIS-MCDA) when applied to disaster modeling. Technically speaking, GIS-MCDA model outcomes are prone to multiple types of uncertainty and error. In order to minimize the inherent uncertainty, within this research we introduced a novel approach of spatial explicit uncertainty and sensitivity analysis for GIS-MCDA models. This novel approach is developed based on early works published by FEZIZADEH et al. 2014a, 2014b and make...

  5. Patients with multiple synchronous colonic cancer hepatic metastases benefit from enrolment in a “liver first” approach protocol

    Institute of Scientific and Technical Information of China (English)

    Dimitrios; Kardassis; Achilleas; Ntinas; Dimosthenis; Miliaras; Alexros; Kofokotsios; Konstantinos; Papazisis; Dionisios; Vrochides

    2014-01-01

    AIM: To assess a protocol for treating patients with multiple synchronous colonic cancer liver metastases, which are unresectable in one stage. METHODS: Patients enrolled in the "liver first" protocol presented with colon-only(not rectal) cancer and multiple synchronous hepatic metastases(type Ⅱ or Ⅲ). All patients showed good performance status(ECOG PS 0-1) and were treated with curative intent. Complete oncologic staging including positron emission tomography-computed tomography was performed in order to rule out extrahepatic disease. If bowel obstruction was imminent, an intraluminal colonic stent was placed endoscopically. Subsequently, all patients received standardised neo-adjuvant chemotherapy, that is, FOLFOX or XELOX regimens combined with an antiangiogenic agent(bevacizumab or cetuximab). Provided that a response to chemotherapy was observed, patients underwent either one or two hepatectomies with or without portal vein embolization followed by the indicated colectomy. Further chemotherapy was administered after each procedure. Re-staging was performed after each chemotherapeutic treatment. Disease progression at any stage resulted in discontinuation of the protocol and conversion to palliative disease management.RESULTS: Prospectively recorded data from 11 consecutive patients(8 men) were analysed for this study. Their mean age at the time of their first assessment was 65.7(SD ± 15.3) years. Six(54.6%) patients presented with type Ⅲ metastatic disease. The minimum and maximum follow-up periods were 7.3 and 39.6 mo, respectively. The mean overall survival of all patients was 16.5(95%CI: 10.0-23.2) mo. A colonic stent had to be placed in 5(45.5%) patients due to the onset of an intraluminal obstruction. Four(36.4%) patients succeeded in completing all planned surgical operations. Their mean overall survival was 27.2(95%CI: 15.1-39.3) mo and the mean disease-free survival was 7.7(95%CI: 3.0-12.5) mo. Patients, who were obliged to shift to palliative

  6. The impact of farmers’ participation in field trials in creating awareness and stimulating compliance with the World Health Organization’s farm-based multiple-barrier approach

    DEFF Research Database (Denmark)

    Amponsah, Owusu; Vigre, Håkan; Schou, Torben Wilde;

    2016-01-01

    The results of a study aimed as assessing the extent to which urban vegetable farmers’ participation in field trials can impact on their awareness and engender compliance with the World Health Organization’s farm-based multiple-barrier approach are presented in this paper. Both qualitative...

  7. A Bayesian Approach to a Multiple-Group Latent Class-Profile Analysis: The Timing of Drinking Onset and Subsequent Drinking Behaviors among U.S. Adolescents

    Science.gov (United States)

    Chung, Hwan; Anthony, James C.

    2013-01-01

    This article presents a multiple-group latent class-profile analysis (LCPA) by taking a Bayesian approach in which a Markov chain Monte Carlo simulation is employed to achieve more robust estimates for latent growth patterns. This article describes and addresses a label-switching problem that involves the LCPA likelihood function, which has…

  8. Developing Stimulus Control of the High-Rate Social-Approach Responses of an Adult with Mental Retardation: A Multiple-Schedule Evaluation

    Science.gov (United States)

    Grow, Laura L.; LeBlanc, Linda A.; Carr, James E.

    2010-01-01

    We evaluated a multiple schedule in which the extinction (S-) components were signaled overtly by a black lanyard and the reinforcement (S+) components were not correlated with any programmed stimuli in developing stimulus control over the high-rate social-approach responses of an adult with mental retardation. Responding was consistently low in…

  9. [Affective and psychotic disorders in multiple sclerosis].

    Science.gov (United States)

    Pozuelo-Moyano, Beatriz; Benito-León, Julián

    2015-12-01

    Introduccion. La esclerosis multiple (EM) es la segunda causa mas importante de discapacidad de origen neurologico en los adultos jovenes. Tanto la sintomatologia fisica como la psiquiatrica (trastornos afectivos y psicoticos) impactan de manera negativa en la calidad de vida relacionada con la salud de los pacientes con EM. Objetivo. Elucidar de modo critico la prevalencia y la patogenia de los sintomas afectivos y psicoticos presentes en la EM. Desarrollo. Se incluye una actualizacion de los estudios publicados mas significativos que han analizado la prevalencia y la patogenia de la sintomatologia afectiva y psicotica en los pacientes con EM. Para explorar la asociacion entre los sintomas afectivos y psicoticos con la EM se ha revisado la evidencia disponible hasta el momento. Conclusiones. La depresion es el trastorno psiquiatrico mas frecuente en la EM. Es necesaria mas investigacion para elucidar los mecanismos subyacentes que pueden provocar sintomas afectivos y psicoticos en la EM. El control de dichos sintomas en los pacientes de EM podria mejorar su calidad de vida relacionada con la salud.

  10. An efficient sequential approach to tracking multiple objects through crowds for real-time intelligent CCTV systems.

    Science.gov (United States)

    Li, Liyuan; Huang, Weimin; Gu, Irene Yu-Hua; Luo, Ruijiang; Tian, Qi

    2008-10-01

    Efficiency and robustness are the two most important issues for multiobject tracking algorithms in real-time intelligent video surveillance systems. We propose a novel 2.5-D approach to real-time multiobject tracking in crowds, which is formulated as a maximum a posteriori estimation problem and is approximated through an assignment step and a location step. Observing that the occluding object is usually less affected by the occluded objects, sequential solutions for the assignment and the location are derived. A novel dominant color histogram (DCH) is proposed as an efficient object model. The DCH can be regarded as a generalized color histogram, where dominant colors are selected based on a given distance measure. Comparing with conventional color histograms, the DCH only requires a few color components (31 on average). Furthermore, our theoretical analysis and evaluation on real data have shown that DCHs are robust to illumination changes. Using the DCH, efficient implementations of sequential solutions for the assignment and location steps are proposed. The assignment step includes the estimation of the depth order for the objects in a dispersing group, one-by-one assignment, and feature exclusion from the group representation. The location step includes the depth-order estimation for the objects in a new group, the two-phase mean-shift location, and the exclusion of tracked objects from the new position in the group. Multiobject tracking results and evaluation from public data sets are presented. Experiments on image sequences captured from crowded public environments have shown good tracking results, where about 90% of the objects have been successfully tracked with the correct identification numbers by the proposed method. Our results and evaluation have indicated that the method is efficient and robust for tracking multiple objects (>or= 3) in complex occlusion for real-world surveillance scenarios.

  11. 教师教育研究的多元路径观照%Multiple Approaches to Teacher Education Research

    Institute of Scientific and Technical Information of China (English)

    张晓峰

    2014-01-01

    Empirical study should be the main body in teacher education research , for research is based on data collection in essence . Teachers are involved in educational activities . They should be encouraged to carry out teacher education research . Quantitative study and qualitative study are the two basic approaches to teacher education research . They have different characteristics and are suitable for different research settings . An open and multiple methodology should be adopted in teacher education research .%研究本质上是基于经验证据的,经验研究应该是构成教师教育研究的主体。广大教师是教师教育活动的当事人,应该广泛邀请他们从事教师教育研究。在教师教育研究中,量化研究与质性研究是两种基本的认识路径,各有不同的特点和适用对象。当前,重视研究的多元方法论,特别是将质性研究和量化研究并重,已成为许多研究者的共识。要以多元、开放的方法论推进教师教育研究,促进教师教育研究的健康发展。

  12. Esclerosis sistémica

    OpenAIRE

    Margolles, Mario; Mérida, Sara

    2014-01-01

    Enfermedades Raras en Asturias. Dirección General de Salud Pública y Participación. Informes breves 10 Also called scleroderma (if it affects the skin) or syndrome CREST is a connective tissue disease characterized by changes in skin, blood vessels, skeletal muscles and in to unknown causes. Este proyecto ha sido financiado a cargo de los fondos para la cohesión territorial 2010 del Ministerio de Sanidad y Política Social que fueron aprobados en el CISNS, como apoyo a la ...

  13. Treatment of advanced head and neck cancer: multiple daily dose fractionated radiation therapy and sequential multimodal treatment approach.

    Science.gov (United States)

    Nissenbaum, M; Browde, S; Bezwoda, W R; de Moor, N G; Derman, D P

    1984-01-01

    Fifty-eight patients with advanced head and neck cancer were entered into a randomised trial comparing chemotherapy (DDP + bleomycin) alone, multiple daily fractionated radiation therapy, and multimodality therapy consisting of chemotherapy plus multiple fractionated radiation therapy. Multimodal therapy gave a significantly higher response rate (69%) than either single-treatment modality. The use of a multiple daily dose fractionation allowed radiation therapy to be completed over 10 treatment days, and the addition of chemotherapy to the radiation treatment did not significantly increase toxicity. Patients receiving multimodal therapy also survived significantly longer (median 50 weeks) than those receiving single-modality therapy (median 24 weeks).

  14. Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer's disease-experimental approach and therapeutic implications

    OpenAIRE

    Jun eWang; Weina eBi; Alice eCheng; Daniel eFreire; Prashant eVempati; Wei eZhao; Bing eGong; Elsa eJanle; Tzu-Ying eChen; Mario eFerruzzi; James eSchmeidler; Lap eHo; Giulio Maria Pasinetti

    2014-01-01

    Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease of aging and currently has no cure. Its onset and progression are influenced by multiple factors. There is growing consensus that successful treatment will rely on simultaneously targeting multiple pathological features of AD. Polyphenol compounds have many proven health benefits. In this study, we tested the hypothesis that combining three polyphenolic preparations (grape seed extract, resveratrol and Concord grape ju...

  15. A critical assessment of shrinkage-based regression approaches for estimating the adverse health effects of multiple air pollutants

    Science.gov (United States)

    Roberts, Steven; Martin, Michael

    Most investigations of the adverse health effects of multiple air pollutants analyse the time series involved by simultaneously entering the multiple pollutants into a Poisson log-linear model. Concerns have been raised about this type of analysis, and it has been stated that new methodology or models should be developed for investigating the adverse health effects of multiple air pollutants. In this paper, we introduce the use of the lasso for this purpose and compare its statistical properties to those of ridge regression and the Poisson log-linear model. Ridge regression has been used in time series analyses on the adverse health effects of multiple air pollutants but its properties for this purpose have not been investigated. A series of simulation studies was used to compare the performance of the lasso, ridge regression, and the Poisson log-linear model. In these simulations, realistic mortality time series were generated with known air pollution mortality effects permitting the performance of the three models to be compared. Both the lasso and ridge regression produced more accurate estimates of the adverse health effects of the multiple air pollutants than those produced using the Poisson log-linear model. This increase in accuracy came at the expense of increased bias. Ridge regression produced more accurate estimates than the lasso, but the lasso produced more interpretable models. The lasso and ridge regression offer a flexible way of obtaining more accurate estimation of pollutant effects than that provided by the standard Poisson log-linear model.

  16. Designing Multi Objective Facility Location Models Based on Multiple Type Facility Dispersion and Data Envelopment Analysis Using Fuzzy Goal Programing Approach

    OpenAIRE

    Mahdi Karbasian1; Mahdi Dashti

    2013-01-01

    In this paper, four different multiple-type dispersion facilities location modeling formulations have been developed, which utilize efficiency measures of Data Envelopment Analysis to find optimal and efficient facility location patterns. While the problems studied previously do not clearly indicate which candidate is elected by a unit, simultaneous DEA approach has been used for analysis. In these models, existing facilities are considered. These models with two objectives, considerabely mat...

  17. Multiple-Strain Approach and Probabilistic Modeling of Consumer Habits in Quantitative Microbial Risk Assessment: A Quantitative Assessment of Exposure to Staphylococcal Enterotoxin A in Raw Milk.

    Science.gov (United States)

    Crotta, Matteo; Rizzi, Rita; Varisco, Giorgio; Daminelli, Paolo; Cunico, Elena Cosciani; Luini, Mario; Graber, Hans Ulrich; Paterlini, Franco; Guitian, Javier

    2016-03-01

    Quantitative microbial risk assessment (QMRA) models are extensively applied to inform management of a broad range of food safety risks. Inevitably, QMRA modeling involves an element of simplification of the biological process of interest. Two features that are frequently simplified or disregarded are the pathogenicity of multiple strains of a single pathogen and consumer behavior at the household level. In this study, we developed a QMRA model with a multiple-strain approach and a consumer phase module (CPM) based on uncertainty distributions fitted from field data. We modeled exposure to staphylococcal enterotoxin A in raw milk in Lombardy; a specific enterotoxin production module was thus included. The model is adaptable and could be used to assess the risk related to other pathogens in raw milk as well as other staphylococcal enterotoxins. The multiplestrain approach, implemented as a multinomial process, allowed the inclusion of variability and uncertainty with regard to pathogenicity at the bacterial level. Data from 301 questionnaires submitted to raw milk consumers were used to obtain uncertainty distributions for the CPM. The distributions were modeled to be easily updatable with further data or evidence. The sources of uncertainty due to the multiple-strain approach and the CPM were identified, and their impact on the output was assessed by comparing specific scenarios to the baseline. When the distributions reflecting the uncertainty in consumer behavior were fixed to the 95th percentile, the risk of exposure increased up to 160 times. This reflects the importance of taking into consideration the diversity of consumers' habits at the household level and the impact that the lack of knowledge about variables in the CPM can have on the final QMRA estimates. The multiple-strain approach lends itself to use in other food matrices besides raw milk and allows the model to better capture the complexity of the real world and to be capable of geographical

  18. The reconstruction of late Holocene environmental change at Redhead Lagoon, NSW, using a multiple-method approach

    Energy Technology Data Exchange (ETDEWEB)

    Franklin, N.; Gale, S. [University of Sydney, Sydney, NSW (Australia). School of Geoscience, Division of Geography; Heijnis, H. [Australian Nuclear Science and Technology Organisation (ANSTO), Lucas Heights, NSW (Australia)

    1999-11-01

    accumulation. However, since the 1960s, urbanisation has also contributed to accelerated sedimentation and urban pollution within the basin. The sedimentary record also illustrates dramatic and sudden changes in sediment chemistry. In particular, atmospheric pollution from industrial activities has affected lake sediment quality. Increases in heavy metal trace elements such as lead, zinc, arsenic, nickel and copper have been attributed to fallout of atmospheric particulate matter from the nearby smelter at Cockle Creek and the coal-fired power stations around Lake Macquarie. This study shows that a multiple-method approach is capable of yielding important insights into the history of environmental conditions within a single catchment. A combination of analyses together with documented records of land use changes can improve the reliability of the dates obtained by the more established chronological techniques

  19. Advantages of the Multiple Case Series Approach to the Study of Cognitive Deficits in Autism Spectrum Disorder

    Science.gov (United States)

    Towgood, Karren J.; Meuwese, Julia D. I.; Gilbert, Sam J.; Turner, Martha S.; Burgess, Paul W.

    2009-01-01

    In the neuropsychological case series approach, tasks are administered that tap different cognitive domains, and differences within rather than across individuals are the basis for theorising; each individual is effectively their own control. This approach is a mainstay of cognitive neuropsychology, and is particularly suited to the study of…

  20. A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies

    NARCIS (Netherlands)

    Lange, C; Lyon, H; DeMeo, D; Raby, B; Silverman, EK; Weiss, ST

    2003-01-01

    We introduce a new powerful nonparametric testing strategy for family-based association studies in which multiple quantitative traits are recorded and the phenotype with the strongest genetic component is not known prior to the analysis. In the first stage, using a population-based test based on the

  1. Employment among Working-Age Adults with Multiple Sclerosis: A Data-Mining Approach to Identifying Employment Interventions

    Science.gov (United States)

    Bishop, Malachy; Chan, Fong; Rumrill, Phillip D., Jr.; Frain, Michael P.; Tansey, Timothy N.; Chiu, Chung-Yi; Strauser, David; Umeasiegbu, Veronica I.

    2015-01-01

    Purpose: To examine demographic, functional, and clinical multiple sclerosis (MS) variables affecting employment status in a national sample of adults with MS in the United States. Method: The sample included 4,142 working-age (20-65 years) Americans with MS (79.1% female) who participated in a national survey. The mean age of participants was…

  2. Enhancing learning at work. How to combine theoretical and data-driven approaches, and multiple levels of data?

    NARCIS (Netherlands)

    Kalakoski, V.; Ratilainen, H.; Drupsteen, L.

    2015-01-01

    This research plan focuses on learning at work. Our aim is to gather empirical data on multiple factors that can affect learning for work, and to apply computational methods in order to understand the preconditions of effective learning. The design will systematically combine theory- and data-driven

  3. Columns formed by multiple twinning in nickel layers—An approach of grain boundary engineering by electrodeposition

    DEFF Research Database (Denmark)

    Alimadadi, Hossein; da Silva Fanta, Alice Bastos; Somers, Marcel A. J.;

    2013-01-01

    Complementary microscopic and diffraction based methods revealed a peculiar microstructure of electrodeposited nickel. For the as-deposited layer, thus, without any additional treatment, multiple twinning yields a high population of Σ3n boundaries, which interrupts the network of normal high angle...

  4. Multivariate Regression Approach To Integrate Multiple Satellite And Tide Gauge Data For Real Time Sea Level Prediction

    DEFF Research Database (Denmark)

    Cheng, Yongcun; Andersen, Ole Baltazar; Knudsen, Per

    2010-01-01

    The Sea Level Thematic Assembly Center in the EUFP7 MyOcean project aims at build a sea level service for multiple satellite sea level observations at a European level for GMES marine applications. It aims to improve the sea level related products to guarantee the sustainability and the quality o...... stations with satellite altimetry....

  5. Advanced in silico approaches for drug discovery: Mining information from multiple biological and chemical data through mtk-QSBER and pt-QSPR strategies.

    Science.gov (United States)

    Speck-Planche, Alejandro; Cordeiro, Maria Natália Dias Soeiro

    2017-01-24

    The last decade has been seeing an increase of public-private partnerships in drug discovery, mostly driven by factors such as the decline in productivity, the high costs, time, and resources needed, along with the requirements of regulatory agencies. In this context, traditional computer-aided drug discovery techniques have been playing an important role, enabling the identification of new molecular entities at early stages. However, recent advances in chemoinformatics and systems pharmacology, alongside with a growing body of high quality, publicly accessible medicinal chemistry data, have led to the emergence of novel in silico approaches. These novel approaches are able to integrate a vast amount of multiple chemical and biological data into a single modeling equation. The present review analyzes two main kinds of such cutting-edge in silico approaches. In a first subsection, we discuss the updates on multitasking models for quantitative structure-biological effect relationships (mtk-QSBER), whose applications have been significantly increasing in the past years. In a second subsection, we provide detailed information regarding a novel approach that combines perturbation theory with quantitative structure-property relationships modeling tools (pt-QSPR). Finally, and most importantly, we show that the joint use of mtk-QSBER and pt-QSPR modeling tools are apt to guide drug discovery through its multiple stages: from in vitro assays to preclinical studies and clinical trials.

  6. Placa fibrosa de la frente o del cuero cabelludo: Un marcador cutáneo temprano del complejo de la esclerosis tuberosa Forehead or scalp fibrous plaque: An earley cutaneous marker in tuberous sclerosis complex

    Directory of Open Access Journals (Sweden)

    A. E Saponaro

    2010-09-01

    Full Text Available El complejo de la Esclerosis tuberosa es una afección hereditaria, que se transmite en forma autosómica dominante. Se caracteriza por convulsiones, retraso mental y manifestaciones en diversos órganos. Los signos cutáneos suelen ser determinantes para el diagnóstico de la enfermedad. Entre éstos se destaca la placa fibrosa, la que se localiza más frecuentemente en la frente, pero puede observarse en cualquier área del cuero cabelludo. Cuando está presente, suele ser el signo cutáneo inicial de la enfermedad, como ocurrió en nuestro paciente, subdiagnosticado. Su importancia radica entonces en reconocerlo como un marcador precoz y patognomónico de la enfermedad.The complex of tuberous sclerosis is an hereditary disease that passes in the autosomal dominant way. It is characterized by convulsions, mental retardation and manifestations in different organs. The cutaneous signs are used to be determinant for the diagnosis of the illness. Among these, it is important the fibrous plaque, which is usually localized in the forehead, but it can also be observed in any area of the scalp.When it is presented, it is used to be the first cutaneous sign of the illness, and like it happened in our patient, underdiagnosed. So, the importance of the fibrous plaque lies in recognizing it as an early cutaneous marker and pathognomonic of the disease.

  7. Approach to a case of multiple irregular red cell antibodies in a liver transplant recipient: Need for developing competence

    Directory of Open Access Journals (Sweden)

    Ravi C Dara

    2015-01-01

    Full Text Available Liver transplant procedure acts as a challenge for transfusion services in terms of specialized blood components, serologic problems, and immunologic effects of transfusion. Red cell alloimmunization in patients awaiting a liver transplant complicate the process by undue delay or unavailability of compatible red blood cell units. Compatible blood units can be provided by well-equipped immunohematology laboratory, which has expertise in resolving these serological problems. This report illustrates resolution of a case with multiple alloantibodies using standard techniques, particularly rare antisera. Our case re-emphasizes the need for universal antibody screening in all patients as part of pretransfusion testing, which helps to identify atypical antibodies and plan for appropriate transfusion support well in time. We recommend that the centers, especially the ones that perform complex procedures like solid organ transplants and hematological transplants should have the necessary immunohematological reagents including rare antisera to resolve complex cases of multiple antibodies as illustrated in this case.

  8. Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer’s disease: Experimental approach and therapeutic implications

    Directory of Open Access Journals (Sweden)

    Jun eWang

    2014-03-01

    Full Text Available Alzheimer’s disease (AD is the most prevalent neurodegenerative disease of aging and currently has no cure. Its onset and progression are influenced by multiple factors. There is growing consensus that successful treatment will rely on simultaneously targeting multiple pathological features of AD. Polyphenol compounds have many proven health benefits. In this study, we tested the hypothesis that combining three polyphenolic preparations (grape seed extract, resveratrol and Concord grape juice extract, with different polyphenolic compositions and partially redundant bioactivities, may simultaneously and synergistically mitigate amyloid-β (Aβ mediated neuropathology and cognitive impairments in a mouse model of AD. We found that administration of the polyphenols in combination did not alter the profile of bioactive polyphenol metabolites in the brain. We also found that combination treatment resulted in better protection against cognitive impairments compared to individual treatments, in J20 AD mice. Electrophysiological examination showed that acute treatment with select brain penetrating polyphenol metabolites, derived from these polyphenols, improved oligomeric Aβ (oAβ-induced long term potentiation (LTP deficits in hippocampal slices. Moreover, we found greatly reduced total amyloid content in the brain following combination treatment. Our studies provided experimental evidence that application of polyphenols targeting multiple disease-mechanisms may yield a greater likelihood of therapeutic efficacy.

  9. Assessment of Serum Nitrogen Species and Inflammatory Parameters in Relapsing-Remitting Multiple Sclerosis Patients Treated with Different Therapeutic Approaches

    Directory of Open Access Journals (Sweden)

    Natalia Niedziela

    2016-01-01

    Full Text Available The role of nitric oxide and its reactive derivatives (NOx is well known in the pathogenesis of multiple sclerosis, which is an inflammatory disease while NOx seems to be important in coordinating inflammatory response. The purpose of the present study was to assess serum NOx as one of the nitrogen species and inflammatory parameters in relapsing-remitting multiple sclerosis patients and to compare the effectiveness of various types of disease-modifying therapies that reduce nitric oxide and inflammatory biomarkers. Elevated NOx level was observed in patients who received the first-line disease-modifying therapy (interferons beta-1a and beta-1b in comparison with the subjects treated with the second-line disease-modifying therapy (natalizumab; fingolimod and healthy controls without significant differences in C-reactive protein and interleukin-1 beta. A negative correlation was observed between serum NOx level and the duration of multiple sclerosis confirmed in the whole study population and in subjects treated with the first-line agents. Only serum NOx, concentration could reveal a potential efficacy of disease-modifying therapy with a better reduction in NOx level due to the second-line agents of disease-modifying therapy.

  10. Human-centered approaches in geovisualization design: investigating multiple methods through a long-term case study.

    Science.gov (United States)

    Lloyd, David; Dykes, Jason

    2011-12-01

    Working with three domain specialists we investigate human-centered approaches to geovisualization following an ISO13407 taxonomy covering context of use, requirements and early stages of design. Our case study, undertaken over three years, draws attention to repeating trends: that generic approaches fail to elicit adequate requirements for geovis application design; that the use of real data is key to understanding needs and possibilities; that trust and knowledge must be built and developed with collaborators. These processes take time but modified human-centred approaches can be effective. A scenario developed through contextual inquiry but supplemented with domain data and graphics is useful to geovis designers. Wireframe, paper and digital prototypes enable successful communication between specialist and geovis domains when incorporating real and interesting data, prompting exploratory behaviour and eliciting previously unconsidered requirements. Paper prototypes are particularly successful at eliciting suggestions, especially for novel visualization. Enabling specialists to explore their data freely with a digital prototype is as effective as using a structured task protocol and is easier to administer. Autoethnography has potential for framing the design process. We conclude that a common understanding of context of use, domain data and visualization possibilities are essential to successful geovis design and develop as this progresses. HC approaches can make a significant contribution here. However, modified approaches, applied with flexibility, are most promising. We advise early, collaborative engagement with data – through simple, transient visual artefacts supported by data sketches and existing designs – before moving to successively more sophisticated data wireframes and data prototypes.

  11. [Compliance of the guidelines of the Spanish Neurology Society in the treatment of patients with multiple sclerosis].

    Science.gov (United States)

    Oreja-Guevara, Celia; Río, Jordi; Gobartt, Ana L

    2015-08-16

    Introduccion. El tratamiento de la esclerosis multiple se basa en la administracion de farmacos modificadores de la enfermedad (FAME), utilizados para frenar el curso natural de la enfermedad. Objetivo. Evaluar el grado de cumplimiento de las guias terapeuticas de la Sociedad Española de Neurologia (SEN) de 2010 por parte de los neurologos. Pacientes y metodos. Estudio observacional, retrospectivo y multicentrico de 218 pacientes adultos con esclerosis multiple de al menos cinco años de evolucion y en tratamiento con FAME. Los datos se obtuvieron de la historia clinica y se compararon con las recomendaciones de la SEN. Resultados. Segun las guias de la SEN de 2010, el 82% de los pacientes presentaba respuesta clinica adecuada, y el 18%, respuesta clinica inadecuada al FAME actual; el 94% y 92%, respectivamente, mantuvieron ese tratamiento. Los pacientes en los que la respuesta clinica inadecuada no origino un cambio del FAME actual llevaban en tratamiento mas tiempo y experimentaron con mayor frecuencia progresion de su discapacidad e incremento del numero de brotes. El 48% de los pacientes inicio tratamiento de primera linea con interferon beta-1a, administrado por via subcutanea (29%) o intramuscular (19%), seguido de interferon beta-1b y acetato de glatiramero. Algunos pacientes recibieron tratamientos de segunda linea como segunda/tercera opcion (15% y 28%, respectivamente), pero el uso de estos tratamientos (especialmente natalizumab) solo se generalizo a partir de la cuarta linea de tratamiento. Conclusiones. De acuerdo con las guias de la SEN de 2010, la mayoria de los pacientes tuvo una respuesta clinica adecuada. Un elevado porcentaje de pacientes con respuesta clinica inadecuada continuo con el tratamiento actual.

  12. Primary Sclerosing Cholangitis: Multiple Phenotypes, Multiple Approaches.

    Science.gov (United States)

    Sarkar, Souvik; Bowlus, Christopher L

    2016-02-01

    Primary sclerosing cholangitis (PSC) is a heterogeneous, idiopathic, inflammatory disorder frequently associated with inflammatory bowel diseases. PSC patients may be classified into several subphenotypes. Investigations of pediatric, nonwhite, and female PSC patients have revealed distinguishing features. The natural history of PSC is variable in progression with numerous possible clinical outcomes. PSC patients may suffer bacterial cholangitis, cholangiocarcinoma, or colorectal adenocarcinoma. Treatments focusing on bile acid therapy and immunosuppression have not proven beneficial. Interest in PSC and international collaboration has led to improved understanding of the heterogeneity and the genetic structure and introduced possible effective therapeutics.

  13. A comparative study of multiple regression analysis and back propagation neural network approaches on plain carbon steel in submerged-arc welding

    Indian Academy of Sciences (India)

    ABHIJIT SARKAR; PRASENJIT DEY; R N RAI; SUBHAS CHANDRA SAHA

    2016-05-01

    Weld bead plays an important role in determining the quality of welding particularly in high heat input processes. This research paper presents the development of multiple regression analysis (MRA) and artificial neural network (ANN) models to predict weld bead geometry and HAZ width in submerged arcwelding process. Design of experiments is based on Taguchi’s L16 orthogonal array by varying wire feed rate,transverse speed and stick out to develop a multiple regression model, which has been checked for adequacy andsignificance. Also, ANN model was accomplished with the back propagation approach in MATLAB program to predict bead geometry and HAZ width. Finally, the results of two prediction models were compared and analyzed. It is found that the error related to the prediction of bead geometry and HAZ width is smaller in ANN than MRA.

  14. A General Micro-Level Modeling Approach to Analyzing Interconnected SDGs: Achieving SDG 6 and More through Multiple-Use Water Services (MUS

    Directory of Open Access Journals (Sweden)

    Ralph P. Hall

    2017-02-01

    Full Text Available The 2030 agenda presents an integrated set of Sustainable Development Goals (SDGs and targets that will shape development activities for the coming decade. The challenge now facing development organizations and governments is how to operationalize this interconnected set of goals and targets through effective projects and programs. This paper presents a micro-level modeling approach that can quantitatively assess the impacts associated with rural water interventions that are tailored to specific communities. The analysis focuses on how a multiple-use water services (MUS approach to SDG 6 could reinforce a wide range of other SDGs and targets. The multilevel modeling framework provides a generalizable template that can be used in multiple sectors. In this paper, we apply the methodology to a dataset on rural water services from Mozambique to show that community-specific equivalents of macro-level variables used in the literature such as Cost of Illness (COI avoided can provide a better indication of the impacts of a specific intervention. The proposed modeling framework presents a new frontier for designing projects in any sector that address the specific needs of communities, while also leveraging the knowledge gained from previous projects in any country. The approach also presents a way for agencies and organizations to design projects or programs that bridge sectors/disciplines (water, irrigation, health, energy, economic development, etc. to advance an interconnected set of SDGs and targets.

  15. Stepped MS(All) Relied Transition (SMART): An approach to rapidly determine optimal multiple reaction monitoring mass spectrometry parameters for small molecules.

    Science.gov (United States)

    Ye, Hui; Zhu, Lin; Wang, Lin; Liu, Huiying; Zhang, Jun; Wu, Mengqiu; Wang, Guangji; Hao, Haiping

    2016-02-11

    Multiple reaction monitoring (MRM) is a universal approach for quantitative analysis because of its high specificity and sensitivity. Nevertheless, optimization of MRM parameters remains as a time and labor-intensive task particularly in multiplexed quantitative analysis of small molecules in complex mixtures. In this study, we have developed an approach named Stepped MS(All) Relied Transition (SMART) to predict the optimal MRM parameters of small molecules. SMART requires firstly a rapid and high-throughput analysis of samples using a Stepped MS(All) technique (sMS(All)) on a Q-TOF, which consists of serial MS(All) events acquired from low CE to gradually stepped-up CE values in a cycle. The optimal CE values can then be determined by comparing the extracted ion chromatograms for the ion pairs of interest among serial scans. The SMART-predicted parameters were found to agree well with the parameters optimized on a triple quadrupole from the same vendor using a mixture of standards. The parameters optimized on a triple quadrupole from a different vendor was also employed for comparison, and found to be linearly correlated with the SMART-predicted parameters, suggesting the potential applications of the SMART approach among different instrumental platforms. This approach was further validated by applying to simultaneous quantification of 31 herbal components in the plasma of rats treated with a herbal prescription. Because the sMS(All) acquisition can be accomplished in a single run for multiple components independent of standards, the SMART approach are expected to find its wide application in the multiplexed quantitative analysis of complex mixtures.

  16. Force-based and displacement-based reliability assessment approaches for highway bridges under multiple hazard actions

    Directory of Open Access Journals (Sweden)

    Chao Huang

    2015-08-01

    Full Text Available The strength limit state of American Association of State Highway and Transportation Officials (AASHTO Load and Resistance Factor Design (LRFD Bridge Design Specifications is developed based on the failure probabilities of the combination of non-extreme loads. The proposed design limit state equation (DLSE has been fully calibrated for dead load and live load by using the reliability-based approach. On the other hand, most of DLSEs in other limit states, including the extreme events Ⅰ and Ⅱ, have not been developed and calibrated though taking certain probability-based concepts into account. This paper presents an assessment procedure of highway bridge reliabilities under the limit state of extreme event Ⅰ, i. e., the combination of dead load, live load and earthquake load. A force-based approach and a displacement-based approach are proposed and implemented on a set of nine simplified bridge models. Results show that the displacement-based approach comes up with more convergent and accurate reliabilities for selected models, which can be applied to other hazards.

  17. Multiple-Scenario Unmanned Aerial System Control: A Systems Engineering Approach and Review of Existing Control Methods

    Directory of Open Access Journals (Sweden)

    Christopher M. Eaton

    2016-01-01

    Full Text Available The use of unmanned aerial systems (UASs in both the public and military environments is predicted to grow significantly. As the demand for UASs grows, the availability of more robust and capable vehicles that can perform multiple mission types will be needed. In the public sector, the demand will grow for UASs to be used for agriculture, forestry, and search and rescue missions. Militaries continue to demand more UAS capabilities for diverse operations around the world. Significant research has been performed and continues to progress in the areas of autonomous UAS control. A majority of the work focuses on subsets of UAS control: path planning, autonomy, small UAS controls, and sensors. Minimal work exists on a system-level problem of multiple-scenario UAS control for integrated systems. This paper provides a high-level modular system architecture definition that is modifiable across platform types and mission requirements. A review of the current research and employment of UAS capabilities is provided to evaluate the state of the capabilities required to enable the proposed architecture.

  18. Fibroma desmoplásico de mandíbula asociado a esclerosis tuberosa: Revisión de la literatura y presentación de un caso Desmoplastic fibroma of the jaw associated with tuberous sclerosis: Literature review and case report

    Directory of Open Access Journals (Sweden)

    M. Acosta Feria

    2008-04-01

    Full Text Available La esclerosis tuberosa es una anomalía congénita del desarrollo embrionario que se transmite de forma autosómica dominante caracterizada por la presencia por trastornos neurológicos, cutáneos o dermatológicos, y retraso mental. Se pueden afectar otros órganos y sistemas, y dar manifestaciones orofaciales. La lesión a nivel del esmalte dental constituye la lesión intraoral más frecuente. Rara vez se pueden encontrar lesiones óseas en los maxilares. El fibroma desmoplásico es un infrecuente tumor fibroso intraóseo localmente agresivo de lento crecimiento, que se asocia muy rara vez a la esclerosis tuberosa. Presentamos el caso clínico de un paciente de 33 años afecto de esclerosis tuberosa con una lesión en la mandíbula diagnosticada como fibroma desmoplásico. Se discuten los métodos diagnósticos, presentación clínica y tratamiento.Tuberous sclerosis is a congenital anomaly of embryonic development with an autosomal dominant inheritance. It is characterized by the presence of neurologic and dermatologic disorders and mental retardation. It can affect other organs and systems and produce orofacial manifestations. Dental enamel defects are the most frequent intraoral lesion. Bone lesions rarely occur in the upper jaw. Desmoplastic fibroma is an infrequent, slow-growing, locally aggressive intraosseous fibrous tumor that rarely is associated with tuberous sclerosis. We report the clinical case of a 33-year-old man with tuberous sclerosis and a jaw lesion diagnosed as desmoplastic fibroma. The diagnostic methods, clinical presentation, and treatment are discussed.

  19. An Interdisciplinary Approach in Rehabilitation of an Adult Mutilated Dentition with Multiple Missing Permanent Teeth--A Case Report.

    Science.gov (United States)

    Agrawal, Sarvesh; Jose, Nidhin Philip; Bandi, Rohan S; Jain, Nimit; Rodrigues, Shobha J

    2015-01-01

    Adult orthodontics has been an area of increasing focus in recent times. Comprehensive treatment of adults is more challenging due to a myriad of problems that coexist in an adult that makes treatment planning more challenging. A large number of individuals seek dental care because of aesthetic reasons, that is, the desire to look more attractive by improving their smiles. The role an attractive smile plays on a person's self-image and confidence cannot be overemphasized. Evaluating and treating patients for the purpose of smile design often involves a multi-discipline approach. Achieving an ideal smile may require orthodontics, orthognathic surgery, periodontal therapy, including soft tissue repositioning and bone re-contouring, cosmetic dentistry, and plastic surgery. This aesthetic approach to patient care produces the best dental and dental-facial beauty. This paper describes a case report in which an orthodontist, an endodontist, and a prosthodontist worked as a team to improve the patients smile and confidence.

  20. Enfermedad pulmonar intersticial en Esclerosis Sistémica : diferencia en la presentación clínica y evolución clínica y evolución entre pacientes con anticuerpos Scl-70 frente PM-Scl

    OpenAIRE

    Guillén del Castillo, Alfredo

    2013-01-01

    La esclerosis sistémica (ES) es una enfermedad autoinmune multisistémica que afecta de forma variable a diferentes órganos. En el pulmón produce la enfermedad pulmonar intersticial difusa (EPID), cuyo pronóstico difiere según el autoanticuerpo asociado. Se estudiaron las características clínicas y espirométricas de 63 pacientes diagnosticados de ES y EPID, con positividad para anti-Scl-70 o anti-PM-Scl. En el grupo anti-Scl-70 se documentó mayor prevalencia de úlceras digitales y afección gas...

  1. Fibroma desmoplásico de mandíbula asociado a esclerosis tuberosa: Revisión de la literatura y presentación de un caso Desmoplastic fibroma of the jaw associated with tuberous sclerosis: Literature review and case report

    OpenAIRE

    M. Acosta Feria; P. Infante Cossío; D. López Vaquero; A. Carranza Carranza; J.L. Gutiérrez Pérez

    2008-01-01

    La esclerosis tuberosa es una anomalía congénita del desarrollo embrionario que se transmite de forma autosómica dominante caracterizada por la presencia por trastornos neurológicos, cutáneos o dermatológicos, y retraso mental. Se pueden afectar otros órganos y sistemas, y dar manifestaciones orofaciales. La lesión a nivel del esmalte dental constituye la lesión intraoral más frecuente. Rara vez se pueden encontrar lesiones óseas en los maxilares. El fibroma desmoplásico es un infrecuente tum...

  2. Características de la función ejecutiva en pacientes con esclerosis múltiple progresiva primaria y remitente recurrente entre los 20 y 50 años pertenecientes a la fundación PSIQUE de la ciudad de Medellín, Antioquía

    OpenAIRE

    Fernández Medina, Juliana María

    2012-01-01

    Ubicación en Biblioteca USB Medellín (San Benito): CD-2457t .-- Grupo de Investigación en Neurodesarrollo y Conducta .-- Linea de Investigación: Neurodegenerativa Introducción: La Esclerosis Múltiple (EM) es una enfermedad neurodegenerativa de tipo progresivo que se caracteriza por ser autoinmune, en la cual se genera una acción desmielinizante de la sustancia blanca del cerebro, generando alteraciones neurológicas y neuropsicológicas, donde la causa es multifactorial de etiología desconoc...

  3. Importancia de la terapia física en la optimización de las manifestaciones incapacitantes y de la calidad de vida en pacientes con Esclerosis Lateral Amiotrófica: Revisión bibliográfica.

    OpenAIRE

    Olmo Treceño, Gema del

    2015-01-01

    La esclerosis lateral amiotrófica es la manifestación más frecuente de la enfermedad de la motoneurona. Se trata de una enfermedad neurodegenerativa, progresiva e incapacitante, caracterizada por la afectación de la primera y segunda neurona motora, con baja incidencia y prevalencia y escasa supervivencia. El tratamiento es sintomático, paliativo y multidisciplinar; el único medicamento que se prescribe es el riluzol, como tratamiento modificador de la acción del glutamato. ...

  4. Respuesta clínica y ecocardiográfica en pacientes con hipertensión pulmonar y esclerosis sistémica tratados con sildenafil, atendidos en consulta externa de reumatología, del Hospital Carlos Andrade Marín, entre Marzo 2014 y Enero 2015

    OpenAIRE

    González Castillo, Daniel David

    2015-01-01

    La Esclerosis sistémica e Hipertensión pulmonar son condiciones que afectan la calidad de vida. El monitoreo de la evolución de estas condiciones, a través de ecocardiografía y cateterismo cardiaco junto al tratamiento farmacológico con inhibidores de la 5 fosfodiesterasa debe buscar mejorar la calidad y sobrevida de quienes la padecen. Objetivos: Evaluar la respuesta clínica, tolerancia al ejercicio, y ecocardiográfica de la hipertensión pulmonar al tratamiento con sildenafil en pacientes co...

  5. Ansiedad y depresión en la esclerosis múltiple remitente-recidivante: relación con las alteraciones neuropsicológicas y la percepción subjetiva de deterioro cognitivo en pacientes con discapacidad mínima/leve.

    OpenAIRE

    Teresa Olivares-Pérez; Antonieta Nieto-Barco; Moisés Betancort-Montesinos; Yaiza Pérez- Martín; Miguel Ángel Hernández-Pérez; José Barroso-Ribal

    2009-01-01

    Introducción. La ansiedad y la depresión son trastornos psiquiátricos vinculados a la Esclerosis Múltiple (EM). Sin embargo, la ansiedad no ha sido prácticamente estudiada. Objetivos. Examinar la asociación de ambos trastornos con el deterioro neuropsicológico y su contribución a la autopercepción de deterioro cognitivo. Sujetos y métodos. Se estudiaron 33 pacientes con EM Remitente-Recidivante y niveles de discapacidad mínima-leve. Instrumentos: Hospital Anxiety and Depression Scale (HADS); ...

  6. Ecological effects of multiple stressors on a deep lake (Lago Maggiore, Italy integrating neo and palaeolimnological approaches

    Directory of Open Access Journals (Sweden)

    Davide A.L. Vignati

    2012-01-01

    Full Text Available To understand interactions of lake physical characteristics, trophic dynamics and climate in Lago Maggiore, we compare longterm limnological and meteorological monitoring data and results from sediment cores. We include analyses of nutrients, pigments, diatoms and cladoceran microfossils. Over the past decades, caloric content increased. Eutrophication from the 1960s to early 1980s was followed by oligotrophication. DDTs, PCBs and Hg showed high contamination in the ‘60s, compared to point source inputs in the ‘90s. Algal biomass was predicted by total pigments and some algal specific carotenoids. Following nutrient enrichment, Chydorus sphaericus, and total abundance of cladocerans changed inversely with trophic status. Fewer large Daphnia since the late ‘80s matched an increase in with subfossil Eubosmina mucro lengths. Both were explained by the 10-fold increase in Bythotrephes longimanus from 1987 to 1993, when an increase of its mean annual population density occurred during warmer winter and springs. Bythotrephes remained abundant and further increased during the following 10 years as water temperature increased. We conclude that warmer water affects food chains indirectly by changing habitat use and predator-prey interactions. Relative abundances of Daphnia and its peak population density in the warm year of the oligotrophic period (2003 were close to the record from the mesotrophic period in 1982, supporting the hypothesis that warming can produce a eutrophication-like signal. The study illustrates the complexity of biological responses to synchronous changes in multiple drivers (e.g., eutrophication, fish introduction, ban of fish harvesting, chemical pollution, and climate and, despite this complexity, how Lago Maggiore responded to multiple stressors.

  7. Designing Multi Objective Facility Location Models Based on Multiple Type Facility Dispersion and Data Envelopment Analysis Using Fuzzy Goal Programing Approach

    Directory of Open Access Journals (Sweden)

    Mahdi Karbasian

    2013-01-01

    Full Text Available In this paper, four different multiple-type dispersion facilities location modeling formulations have been developed, which utilize efficiency measures of Data Envelopment Analysis to find optimal and efficient facility location patterns. While the problems studied previously do not clearly indicate which candidate is elected by a unit, simultaneous DEA approach has been used for analysis. In these models, existing facilities are considered. These models with two objectives, considerabely match the real world problems. Since these four models are multiobjective, a fuzzy goal programming approach has been applied to solve the four problems. In this paper, after introducing the proposed models, an example, with the results of numerical calculations has been presented.

  8. A multi-nuclide approach to quantify long-term erosion rates and exposure history through multiple glacial-interglacial cycles

    DEFF Research Database (Denmark)

    Strunk, Astrid; Larsen, Nicolaj Krog; Knudsen, Mads Faurschou;

    possible to resolve the complex pattern of exposure history under a fluctuating ice sheet. In this study, we quantify long-term erosion rates along with durations of multiple exposure periods in West Greenland by applying a novel Markov Chain Monte Carlo (MCMC) inversion approach to existing 10Be and 26Al....... The new MCMC approach allows us to constrain the most likely landscape history based on comparisons between simulated and measured cosmogenic nuclide concentrations. It is a fundamental assumption of the model that the exposure history at the site/location can be divided into two distinct regimes: i...... simulates numerous different landscape scenarios based on these four parameters and zooms in on the most plausible combination of model parameters. We apply the MCMC-model to the concentrations of 10Be and 26Al measured in previously published studies from Upernavik, Uummannaq and Sisimiut and quantify...

  9. Assessment of BTEX-induced health risk under multiple uncertainties at a petroleum-contaminated site: An integrated fuzzy stochastic approach

    Science.gov (United States)

    Zhang, Xiaodong; Huang, Guo H.

    2011-12-01

    Groundwater pollution has gathered more and more attention in the past decades. Conducting an assessment of groundwater contamination risk is desired to provide sound bases for supporting risk-based management decisions. Therefore, the objective of this study is to develop an integrated fuzzy stochastic approach to evaluate risks of BTEX-contaminated groundwater under multiple uncertainties. It consists of an integrated interval fuzzy subsurface modeling system (IIFMS) and an integrated fuzzy second-order stochastic risk assessment (IFSOSRA) model. The IIFMS is developed based on factorial design, interval analysis, and fuzzy sets approach to predict contaminant concentrations under hybrid uncertainties. Two input parameters (longitudinal dispersivity and porosity) are considered to be uncertain with known fuzzy membership functions, and intrinsic permeability is considered to be an interval number with unknown distribution information. A factorial design is conducted to evaluate interactive effects of the three uncertain factors on the modeling outputs through the developed IIFMS. The IFSOSRA model can systematically quantify variability and uncertainty, as well as their hybrids, presented as fuzzy, stochastic and second-order stochastic parameters in health risk assessment. The developed approach haw been applied to the management of a real-world petroleum-contaminated site within a western Canada context. The results indicate that multiple uncertainties, under a combination of information with various data-quality levels, can be effectively addressed to provide supports in identifying proper remedial efforts. A unique contribution of this research is the development of an integrated fuzzy stochastic approach for handling various forms of uncertainties associated with simulation and risk assessment efforts.

  10. 不确定语言环境下的多属性决策方法%Linguistic approaches to multiple attribute decision making in uncertain linguistic setting

    Institute of Scientific and Technical Information of China (English)

    徐泽水; 达庆利

    2004-01-01

    We study multiple attribute decision-making problems with uncertain linguistic information, in which the preference values take the form of uncertain linguistic variables. We introduce some operational laws of uncertain linguistic variables and a formula for the comparison between two uncertain linguistic variables. We propose two new aggregation operators called extended uncertain linguistic aggregation (EULA) operator and interval linguistic aggregation (ILA) operator, and then develop an EULA operator-based linguistic approach and an ILA operator-based linguistic approach, respectively, to multiple attribute decision making in uncertain linguistic setting. The approaches are straightforward and do not produce any loss of information. Finally, an illustrative example is given to verify the developed approaches and to demonstrate their practicality and effectiveness.%研究了偏好值以不确定语言变量形式给出的多属性决策问题. 介绍了不确定语言变量的运算法则, 给出了不确定语言变量之间两两比较的可能度公式, 提出了2种新的数据信息集成算子拓展的不确定语言集成(EULA)算子和区间语言集成(ILA)算子, 并且分别提出了基于EULA算子和基于ILA算子的不确定语言环境下的多属性决策方法. 这2种方法不仅简洁、易懂, 而且在运算过程中不会丢失任何决策信息. 最后, 通过算例对2种方法的实用性和有效性进行了说明.

  11. Summative Integrierte Multiple Choice-Prüfungen: Ein Promotor oder eine Hindernis für bedeutungsorientiertes Lernen der Studierenden [Summative integrative multiple choice examinations: Do they promote or prevent deep learning approaches?

    Directory of Open Access Journals (Sweden)

    Himmelbauer, Monika

    2009-11-01

    Full Text Available [english] Numerous studies provide evidence that the learning approach of students has an influence on their academic performance in examinations. As part of the 2001 reform of the medical curriculum at the Medical University of Vienna, a new assessment system was implemented for knowledge testing that predominantly relies on multiple-choice examinations. The principal purpose of this study was to clarify the question to what extent this rather strong concentration on multiple-choice questions promotes and/or prevents actual learning. Using a standardized questionnaire, 58 students in the 4th year of the curriculum (the first cohort in the test run of the new curriculum, MCW-150 were interviewed. The inventory included learning approaches as well as the academic performance on MC examinations. Results demonstrate that the best test performance correlates with high motivation to achieve, well-organised studying, and orientation towards deeper understanding. Surface approaches - for example memorization - have less relevance for achieving success. According to Coles the role of examinations is to contribute to the way students find their best method for successful studying. Thus one may conclude that students see successful task management less in pure memorization, but view it as a challenge that requires learning on a higher level. Insofar the new assessment system has no adverse impact on learning orientation and learning approach in the cohort MCW-150. [german] Zahlreiche Studien belegen, dass die Lernorientierung von Studierenden einen Einfluss auf deren akademische Prüfungsleistung hat. Im Rahmen einer Studienplanreform im Fach Humanmedizin wurde 2001 an der Medizinischen Universität Wien ein neues Prüfungssystem implementiert, in welchem zur Wissensfeststellung vorwiegend Multiple-Choice-Prüfungen eingesetzt werden. Die Klärung der Frage, inwiefern die ziemlich starke Konzentration auf Multiple-Choice-Prüfungen die Lernorientierung in

  12. Systematic approach to optimize a pretreatment method for ultrasensitive liquid chromatography with tandem mass spectrometry analysis of multiple target compounds in biological samples.

    Science.gov (United States)

    Togashi, Kazutaka; Mutaguchi, Kuninori; Komuro, Setsuko; Kataoka, Makoto; Yamazaki, Hiroshi; Yamashita, Shinji

    2016-08-01

    In current approaches for new drug development, highly sensitive and robust analytical methods for the determination of test compounds in biological samples are essential. These analytical methods should be optimized for every target compound. However, for biological samples that contain multiple compounds as new drug candidates obtained by cassette dosing tests, it would be preferable to develop a single method that allows the determination of all compounds at once. This study aims to establish a systematic approach that enables a selection of the most appropriate pretreatment method for multiple target compounds without the use of their chemical information. We investigated the retention times of 27 known compounds under different mobile phase conditions and determined the required pretreatment of human plasma samples using several solid-phase and liquid-liquid extractions. From the relationship between retention time and recovery in a principal component analysis, appropriate pretreatments were categorized into several types. Based on the category, we have optimized a pretreatment method for the identification of three calcium channel blockers in human plasma. Plasma concentrations of these drugs in a cassette-dose clinical study at microdose level were successfully determined with a lower limit of quantitation of 0.2 pg/mL for diltiazem, 1 pg/mL for nicardipine, and 2 pg/mL for nifedipine.

  13. Controlling a Rehabilitation Robot with Brain-Machine Interface: An approach based on Independent Component Analysis and Multiple Kernel Learning

    Directory of Open Access Journals (Sweden)

    Yi-Hung Liu

    2013-03-01

    Full Text Available Patients suffering from severe motor disabilities usually require assistance from other people when doing rehabilitation exercises, which causes the rehabilitation process to be time-consuming and inconvenient. Therefore, we propose an automatic feature extraction method for a brain-machine interface that allows patients to control a robot using their own brain waves. A brain–machine interface (BMI based on the P300 event-related potential (ERP, called Brain Controlled Rehabilitation System (BCRS, was developed to detect the intentions of patients. Using the BCRS, patients can communicate with the robot through their brain waves. However, deciding how to obtain an automatically extracted, useful EEG signal is a difficult and important problem for BMI research. In this paper, Independent Component Analysis – Multiple Kernel Learning (ICA-MKL is used to directly extract a useful signal and build the classification mode for BCRS. The results reveal that this method is useful for automatically extracting the P300 signal and the accuracy is better than MKL. In additional, the same method can be extended into any motor imaginary area and the accuracy of ICA-MKL for brain imaginary data is also good to removing eye-blink artifacts and the accuracy performance is also good.

  14. Downscaling 250-m MODIS growing season NDVI based on multiple-date landsat images and data mining approaches

    Science.gov (United States)

    Gu, Yingxin; Wylie, Bruce K.

    2015-01-01

    The satellite-derived growing season time-integrated Normalized Difference Vegetation Index (GSN) has been used as a proxy for vegetation biomass productivity. The 250-m GSN data estimated from the Moderate Resolution Imaging Spectroradiometer (MODIS) sensors have been used for terrestrial ecosystem modeling and monitoring. High temporal resolution with a wide range of wavelengths make the MODIS land surface products robust and reliable. The long-term 30-m Landsat data provide spatial detailed information for characterizing human-scale processes and have been used for land cover and land change studies. The main goal of this study is to combine 250-m MODIS GSN and 30-m Landsat observations to generate a quality-improved high spatial resolution (30-m) GSN database. A rule-based piecewise regression GSN model based on MODIS and Landsat data was developed. Results show a strong correlation between predicted GSN and actual GSN (r = 0.97, average error = 0.026). The most important Landsat variables in the GSN model are Normalized Difference Vegetation Indices (NDVIs) in May and August. The derived MODIS-Landsat-based 30-m GSN map provides biophysical information for moderate-scale ecological features. This multiple sensor study retains the detailed seasonal dynamic information captured by MODIS and leverages the high-resolution information from Landsat, which will be useful for regional ecosystem studies.

  15. A Hybrid Multiple Criteria Group Decision-Making Approach for Green Supplier Selection in the TFT-LCD Industry

    Directory of Open Access Journals (Sweden)

    Che-Wei Tsui

    2014-01-01

    Full Text Available The awareness of the need for environmental protection is increasing throughout the world. The focuses of green supplier selection are on considering environmental criteria and strengthening the competitiveness of the entire supply chain. The purpose of this study is to develop a green supplier selection procedure for the thin film transistor liquid crystal display (TFT-LCD industry using polarizer suppliers as an example. First, a decision framework for green supplier selection is developed based on literatures and the supplier audit forms provided by an anonymous flat panel display manufacturer in Taiwan. Then, a hybrid multiple criteria group decision-making (MCGDM method is proposed based on analytic hierarchy process (AHP, entropy, elimination and choice expressing the reality III (ELECTRE III, and the linear assignment method to assist the manufacturer in choosing among four polarizer suppliers. The final ranking results for green supplier selection and different opinions from each department are provided. An improvement report is suggested to enhance suppliers’ performance. For the evaluation procedure, most managers emphasize the importance of current capability and the capability of research and development. Furthermore, we found that the subsidiary supplier should improve quality control competence immediately to be considered as the potential candidate of primary supplier.

  16. Sampled-data-based consensus and containment control of multiple harmonic oscillators: A motion-planning approach

    Science.gov (United States)

    Liu, Yongfang; Zhao, Yu; Chen, Guanrong

    2016-11-01

    This paper studies the distributed consensus and containment problems for a group of harmonic oscillators with a directed communication topology. First, for consensus without a leader, a class of distributed consensus protocols is designed by using motion planning and Pontryagin's principle. The proposed protocol only requires relative information measurements at the sampling instants, without requiring information exchange over the sampled interval. By using stability theory and the properties of stochastic matrices, it is proved that the distributed consensus problem can be solved in the motion planning framework. Second, for the case with multiple leaders, a class of distributed containment protocols is developed for followers such that their positions and velocities can ultimately converge to the convex hull formed by those of the leaders. Compared with the existing consensus algorithms, a remarkable advantage of the proposed sampled-data-based protocols is that the sampling periods, communication topologies and control gains are all decoupled and can be separately designed, which relaxes many restrictions in controllers design. Finally, some numerical examples are given to illustrate the effectiveness of the analytical results.

  17. Statistical epistasis and progressive brain change in schizophrenia: an approach for examining the relationships between multiple genes.

    Science.gov (United States)

    Andreasen, N C; Wilcox, M A; Ho, B-C; Epping, E; Ziebell, S; Zeien, E; Weiss, B; Wassink, T

    2012-11-01

    Although schizophrenia is generally considered to occur as a consequence of multiple genes that interact with one another, very few methods have been developed to model epistasis. Phenotype definition has also been a major challenge for research on the genetics of schizophrenia. In this report, we use novel statistical techniques to address the high dimensionality of genomic data, and we apply a refinement in phenotype definition by basing it on the occurrence of brain changes during the early course of the illness, as measured by repeated magnetic resonance scans (i.e., an 'intermediate phenotype.') The method combines a machine-learning algorithm, the ensemble method using stochastic gradient boosting, with traditional general linear model statistics. We began with 14 genes that are relevant to schizophrenia, based on association studies or their role in neurodevelopment, and then used statistical techniques to reduce them to five genes and 17 single nucleotide polymorphisms (SNPs) that had a significant statistical interaction: five for PDE4B, four for RELN, four for ERBB4, three for DISC1 and one for NRG1. Five of the SNPs involved in these interactions replicate previous research in that, these five SNPs have previously been identified as schizophrenia vulnerability markers or implicate cognitive processes relevant to schizophrenia. This ability to replicate previous work suggests that our method has potential for detecting a meaningful epistatic relationship among the genes that influence brain abnormalities in schizophrenia.

  18. Cooperative Transmission in Mobile Wireless Sensor Networks with Multiple Carrier Frequency Offsets: A Double-Differential Approach

    Directory of Open Access Journals (Sweden)

    Kun Zhao

    2014-01-01

    Full Text Available As a result of the rapidly increasing mobility of sensor nodes, mobile wireless sensor networks (MWSNs would be subject to multiple carrier frequency offsets (MCFOs, which result in time-varying channels and drastically degrade the network performance. To enhance the performance of such MWSNs, we propose a relay selection (RS based double-differential (DD cooperative transmission scheme, termed RSDDCT, in which the best relay sensor node is selected to forward the source sensor node’s signals to the destination sensor node with the detect-and-forward (DetF protocol. Assuming a Rayleigh fading environment, first, exact closed-form expressions for the outage probability and average bit error rate (BER of the RSDDCT scheme are derived. Then, simple and informative asymptotic outage probability and average BER expressions at the large signal-to-noise ratio (SNR regime are presented, which reveal that the RSDDCT scheme can achieve full diversity. Furthermore, the optimum power allocation strategy in terms of minimizing the average BER is investigated, and simple analytical solutions are obtained. Simulation results demonstrate that the proposed RSDDCT scheme can achieve excellent performance over fading channels in the presence of unknown random MCFOs. It is also shown that the proposed optimum power allocation strategy offers substantial average BER performance improvement over the equal power allocation strategy.

  19. Robust inference from multiple test statistics via permutations: a better alternative to the single test statistic approach for randomized trials.

    Science.gov (United States)

    Ganju, Jitendra; Yu, Xinxin; Ma, Guoguang Julie

    2013-01-01

    Formal inference in randomized clinical trials is based on controlling the type I error rate associated with a single pre-specified statistic. The deficiency of using just one method of analysis is that it depends on assumptions that may not be met. For robust inference, we propose pre-specifying multiple test statistics and relying on the minimum p-value for testing the null hypothesis of no treatment effect. The null hypothesis associated with the various test statistics is that the treatment groups are indistinguishable. The critical value for hypothesis testing comes from permutation distributions. Rejection of the null hypothesis when the smallest p-value is less than the critical value controls the type I error rate at its designated value. Even if one of the candidate test statistics has low power, the adverse effect on the power of the minimum p-value statistic is not much. Its use is illustrated with examples. We conclude that it is better to rely on the minimum p-value rather than a single statistic particularly when that single statistic is the logrank test, because of the cost and complexity of many survival trials.

  20. A novel geotechnical/geostatistical approach for exploration and production of natural gas from multiple geologic strata, Phase 1

    Energy Technology Data Exchange (ETDEWEB)

    Overbey, W.K. Jr.; Reeves, T.K.; Salamy, S.P.; Locke, C.D.; Johnson, H.R.; Brunk, R.; Hawkins, L. (BDM Engineering Services Co., Morgantown, WV (United States))

    1991-05-01

    This research program has been designed to develop and verify a unique geostatistical approach for finding natural gas resources. The project has been conducted by Beckley College, Inc., and BDM Engineering Services Company (BDMESC) under contract to the US Department of Energy (DOE), Morgantown Energy Technology Center (METC). This section, Volume II, contains a detailed discussion of the methodology used and the geological and production information collected and analyzed for this study. A companion document, Volume 1, provides an overview of the program, technique and results of the study. In combination, Volumes I and II cover the completion of the research undertaken under Phase I of this DOE project, which included the identification of five high-potential sites for natural gas production on the Eccles Quadrangle, Raleigh County, West Virginia. Each of these sites was selected for its excellent potential for gas production from both relatively shallow coalbeds and the deeper, conventional reservoir formations.

  1. Predictive Modeling of Antioxidant Coumarin Derivatives Using Multiple Approaches: Descriptor-Based QSAR, 3D-Pharmacophore Mapping, and HQSAR

    Directory of Open Access Journals (Sweden)

    Indrani MITRA

    2016-09-01

    Full Text Available The inability of the systemic antioxidants to alleviate the exacerbation of free radical formation from metabolic outputs and environmental pollutants claims an urgent demand for the identification and design of new chemical entities with potent antioxidant activity. In the present work, different QSAR approaches have been utilized for identifying the essential structural attributes imparting a potential antioxidant activity profile of the coumarin derivatives. The descriptor-based QSAR model provides a quantitative outline regarding the structural prerequisites of the molecules, while 3D pharmacophore and HQSAR models emphasize the favourable spatial arrangement of the various chemical features and the crucial molecular fragments, respectively. All the models infer that the fused benzene ring and the oxygen atom of the pyran ring constituting the parent coumarin nucleus capture the prime pharmacophoric features, imparting superior antioxidant activity to the molecules. The developed models may serve as indispensable query tools for screening untested molecules belonging to the class of coumarin derivatives.

  2. Hepatoportal sclerosis clinical different evolutionary stages: presentation of 3 cases and literature review Esclerosis hepatoportal en estadios clínicos evolutivos diferentes: presentación de 3 casos y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    Alejandro Martínez-Caselles

    2012-02-01

    Full Text Available Hepatoportal sclerosis (HPS is characterized by presinusoidal intrahepatic portal hypertension associated with splenomegaly and anemia in patients with non-cirrhotic liver. Liver biopsy is essential, especially to rule out other processes. Being a disease of unknown etiology, the majority of cases have been described in eastern countries. However, it may be an underdiagnosed disease in the West. Symptoms are related to portal hypertension and the clinical spectrum is wide, ranging from anemia with normal liver function tests to bleeding due to esophageal varices. Treatment is directed to the complications and the prognosis is better than in patients with cirrhosis. We report three cases of HPS presenting at different clinical stages and the findings of liver biopsies, the clinical outcomes and a review of scientific literature.La esclerosis hepatoportal se caracteriza por hipertensión portal intrahepática presinusoidal asociada a esplenomegalia y anemia en pacientes con un hígado no cirrótico. La biopsia hepática es fundamental, sobre todo para descartar otros procesos. Se trata de un cuadro de etiología desconocida cuya gran mayoría de los casos se ha descrito en países orientales, si bien podría estar infradiagnosticada en Occidente. Se manifiesta con síntomas asociados a la hipertensión portal y el espectro clínico es muy amplio: desde anemia con pruebas de función hepática normales hasta hemorragia por varices esofagogástricas. Su tratamiento es el de las complicaciones y el pronóstico es mejor que en los pacientes con cirrosis. Presentamos tres casos de EHP que presentan estadios clínicos diferentes, así como los hallazgos de las biopsias hepáticas, su evolución clínica posterior y una revisión de la literatura científica.

  3. Identifying multiple timescale rainfall controls on Mojave Desert ecohydrology using an integrated data and modeling approach for Larrea tridentata

    Science.gov (United States)

    Ng, Gene-Hua Crystal; Bedford, David R.; Miller, David M.

    2015-01-01

    The perennial shrub Larrea tridentata is widely successful in North American warm deserts but is also susceptible to climatic perturbations. Understanding its response to rainfall variability requires consideration of multiple timescales. We examine intra-annual to multi-year relationships using model simulations of soil moisture and vegetation growth over 50 years in the Mojave National Preserve in southeastern California (USA). Ecohydrological model parameters are conditioned on field and remote sensing data using an ensemble Kalman filter. Although no specific periodicities were detected in the rainfall record, simulated leaf-area-index exhibits multi-year dynamics that are driven by multi-year (∼3-years) rains, but with up to a 1-year delay in peak response. Within a multi-year period, Larrea tridentata is more sensitive to winter rains than summer. In the most active part of the root zone (above ∼80 cm), >1-year average soil moisture drives vegetation growth, but monthly average soil moisture is controlled by root uptake. Moisture inputs reach the lower part of the root zone (below ∼80 cm) infrequently, but once there they can persist over a year to help sustain plant growth. Parameter estimates highlight efficient plant physiological properties facilitating persistent growth and high soil hydraulic conductivity allowing deep soil moisture stores. We show that soil moisture as an ecological indicator is complicated by bidirectional interactions with vegetation that depend on timescale and depth. Under changing climate, Larrea tridentata will likely be relatively resilient to shorter-term moisture variability but will exhibit higher sensitivity to shifts in seasonal to multi-year moisture inputs.

  4. Identifying conditions for inducible protein production in E. coli: combining a fed-batch and multiple induction approach

    Directory of Open Access Journals (Sweden)

    Choi Young J

    2006-08-01

    Full Text Available Abstract Background In the interest of generating large amounts of recombinant protein, inducible systems have been studied to maximize both the growth of the culture and the production of foreign proteins. Even though thermo-inducible systems were developed in the late 1970's, the number of studies that focus on strategies for the implementation at bioreactor scale is limited. In this work, the bacteriophage lambda PL promoter is once again investigated as an inducible element but for the production of green fluorescent protein (GFP. Culture temperature, induction point, induction duration and number of inductions were considered as factors to maximize GFP production in a 20-L bioreactor. Results It was found that cultures carried out at 37°C resulted in a growth-associated production of GFP without the need of an induction at 42°C. Specific production was similar to what was achieved when separating the growth and production phases. Shake flask cultures were used to screen for desirable operating conditions. It was found that multiple inductions increased the production of GFP. Induction decreased the growth rate and substrate yield coefficients; therefore, two time domains (before and after induction having different kinetic parameters were created to fit a model to the data collected. Conclusion Based on two batch runs and the simulation of culture dynamics, a pre-defined feeding and induction strategy was developed to increase the volumetric yield of a temperature regulated expression system and was successfully implemented in a 20-L bioreactor. An overall cell density of 5.95 g DW l-1 was achieved without detriment to the cell specific production of GFP; however, the production of GFP was underestimated in the simulations due to a significant contribution of non-growth associated product formation under limiting nutrient conditions.

  5. A targeted spatial-temporal proteomics approach implicates multiple cellular trafficking pathways in human cytomegalovirus virion maturation.

    Science.gov (United States)

    Moorman, Nathaniel J; Sharon-Friling, Ronit; Shenk, Thomas; Cristea, Ileana M

    2010-05-01

    The assembly of infectious virus particles is a complex event. For human cytomegalovirus (HCMV) this process requires the coordinated expression and localization of at least 60 viral proteins that comprise the infectious virion. To gain insight into the mechanisms controlling this process, we identified protein binding partners for two viral proteins, pUL99 (also termed pp28) and pUL32 (pp150), which are essential for HCMV virion assembly. We utilized HCMV strains expressing pUL99 or pUL32 carboxyl-terminal green fluorescent protein fusion proteins from their native location in the HCMV genome. Based on the presence of ubiquitin in the pUL99 immunoisolation, we discovered that this viral protein colocalizes with components of the cellular endosomal sorting complex required for transport (ESCRT) pathway during the initial stages of virion assembly. We identified the nucleocapsid and a large number of tegument proteins as pUL32 binding partners, suggesting that events controlling trafficking of this viral protein in the cytoplasm regulate nucleocapsid/tegument maturation. The finding that pUL32, but not pUL99, associates with clathrin led to the discovery that the two viral proteins traffic via distinct pathways during the early stages of virion assembly. Additional investigation revealed that the majority of the major viral glycoprotein gB initially resides in a third compartment. Analysis of the trafficking of these three viral proteins throughout a time course of virion assembly allowed us to visualize their merger into a single large cytoplasmic structure during the late stages of viral assembly. We propose a model of HCMV virion maturation in which multiple components of the virion traffic independently of one another before merging.

  6. Hematological approaches to multiple myeloma: trends from a Brazilian subset of hematologists. A cross-sectional study

    Directory of Open Access Journals (Sweden)

    Lucila Nassif Kerbauy

    Full Text Available ABSTRACT CONTEXT AND OBJECTIVE: For the last nine years, hematologists and oncologists have gathered annually at an educational symposium organized by a Brazilian and an American hospital. During the 2015 Board Review, a survey among the attendees evaluated the differences in management and treatment methods for multiple myeloma (MM. DESIGN AND SETTING: Cross-sectional study during an educational hematology symposium in São Paulo, Brazil. METHODS: Hematologists present at the symposium gave responses to an electronic survey by means of mobile phone. RESULTS: Among the 350 attendees, 217 answered the questionnaire. Most of the participants believed that immunotargeting agents (iTA might be effective for slowing MM progression in heavily pretreated patients (67% and that continued exposure to therapy might lead to emergence of resistant clones in patients with MM (76%. Most of the physicians use maintenance therapy after hematopoietic stem cell transplantation (95% and 45% of them would further restrict it to post-transplantation patients with underlying high-risk disease. The first-line drugs used for transplantation-ineligible patients (TI-MM were bortezomib-thalidomide-dexamethasone (31%, bortezomib-dexamethasone (28%, lenalidomide-dexamethasone (Rd; 17% and melphalan-based therapy (10%. Lenalidomide was the drug of choice for post-transplantation maintenance for half of the participants. No significant differences were observed regarding age or length of experience. CONCLUSION: The treatment choices for TI-MM patients were highly heterogenous and the melphalan-based regimen represented only 10% of the first-line options. Use of maintenance therapy after transplantation was a common choice. Some results from the survey were divergent from the evidence in the literature.

  7. Selection of an appropriate wastewater treatment technology: a scenario-based multiple-attribute decision-making approach.

    Science.gov (United States)

    Kalbar, Pradip P; Karmakar, Subhankar; Asolekar, Shyam R

    2012-12-30

    Many technological alternatives for wastewater treatment are available, ranging from advanced technologies to conventional treatment options. It is difficult to select the most appropriate technology from among a set of available alternatives to treat wastewater at a particular location. Many factors, such as capital costs, operation and maintenance costs and land requirement, are involved in the decision-making process. Sustainability criteria must also be incorporated into the decision-making process such that appropriate technologies are selected for developing economies such as that of India. A scenario-based multiple-attribute decision-making (MADM) methodology has been developed and applied to the selection of wastewater treatment alternative. The four most commonly used wastewater treatment technologies for treatment of municipal wastewater in India are ranked for various scenarios. Six scenarios are developed that capture the regional and local societal priorities of urban, suburban and rural areas and translate them into the mathematical algorithm of the MADM methodology. The articulated scenarios depict the most commonly encountered decision-making situations in addressing technology selection for wastewater treatment in India. A widely used compensatory MADM technique, TOPSIS, has been selected to rank the alternatives. Seven criteria with twelve indicators are formulated to evaluate the alternatives. Different weight matrices are used for each scenario, depending on the priorities of the scenario. This study shows that it is difficult to select the most appropriate wastewater treatment alternative under the "no scenario" condition (equal weights given to each attribute), and the decision-making methodology presented in this paper effectively identifies the most appropriate wastewater treatment alternative for each of the scenarios.

  8. Identifying multiple time scale rainfall controls on Mojave Desert ecohydrology using an integrated data and modeling approach for Larrea tridentata

    Science.gov (United States)

    Ng, Gene-Hua Crystal; Bedford, David R.; Miller, David M.

    2015-06-01

    The perennial shrub Larrea tridentata is widely successful in North American warm deserts but is also susceptible to climatic perturbations. Understanding its response to rainfall variability requires consideration of multiple time scales. We examine intra-annual to multiyear relationships using model simulations of soil moisture and vegetation growth over 50 years in the Mojave National Preserve in southeastern California (USA). Ecohydrological model parameters are conditioned on field and remote sensing data using an ensemble Kalman filter. Although no specific periodicities were detected in the rainfall record, simulated leaf-area-index exhibits multiyear dynamics that are driven by multiyear (˜3 years) rains, but with up to a 1 year delay in peak response. Within a multiyear period, Larrea tridentata is more sensitive to winter rains than summer. In the most active part of the root zone (above ˜80 cm), >1 year average soil moisture drives vegetation growth, but monthly average soil moisture is controlled by root uptake. Moisture inputs reach the lower part of the root zone (below ˜80 cm) infrequently, but once there they can persist over a year to help sustain plant growth. Parameter estimates highlight efficient plant physiological properties facilitating persistent growth and high soil hydraulic conductivity allowing deep soil moisture stores. We show that soil moisture as an ecological indicator is complicated by bidirectional interactions with vegetation that depend on time scale and depth. Under changing climate, Larrea tridentata will likely be relatively resilient to shorter-term moisture variability but will exhibit higher sensitivity to shifts in seasonal to multiyear moisture inputs.

  9. Relative accuracy of spatial predictive models for lynx Lynx canadensis derived using logistic regression-AIC, multiple criteria evaluation and Bayesian approaches

    Directory of Open Access Journals (Sweden)

    Shelley M. ALEXANDER

    2009-02-01

    Full Text Available We compared probability surfaces derived using one set of environmental variables in three Geographic Information Systems (GIS-based approaches: logistic regression and Akaike’s Information Criterion (AIC, Multiple Criteria Evaluation (MCE, and Bayesian Analysis (specifically Dempster-Shafer theory. We used lynx Lynx canadensis as our focal species, and developed our environment relationship model using track data collected in Banff National Park, Alberta, Canada, during winters from 1997 to 2000. The accuracy of the three spatial models were compared using a contingency table method. We determined the percentage of cases in which both presence and absence points were correctly classified (overall accuracy, the failure to predict a species where it occurred (omission error and the prediction of presence where there was absence (commission error. Our overall accuracy showed the logistic regression approach was the most accurate (74.51%. The multiple criteria evaluation was intermediate (39.22%, while the Dempster-Shafer (D-S theory model was the poorest (29.90%. However, omission and commission error tell us a different story: logistic regression had the lowest commission error, while D-S theory produced the lowest omission error. Our results provide evidence that habitat modellers should evaluate all three error measures when ascribing confidence in their model. We suggest that for our study area at least, the logistic regression model is optimal. However, where sample size is small or the species is very rare, it may also be useful to explore and/or use a more ecologically cautious modelling approach (e.g. Dempster-Shafer that would over-predict, protect more sites, and thereby minimize the risk of missing critical habitat in conservation plans[Current Zoology 55(1: 28 – 40, 2009].

  10. Relative accuracy of spatial predictive models for lynx Lynx canadensis derived using logistic regression-AIC, multiple criteria evaluation and Bayesian approaches

    Institute of Scientific and Technical Information of China (English)

    Hejun KANG; Shelley M.ALEXANDER

    2009-01-01

    We compared probability surfaces derived using one set of environmental variables in three Geographic Information Systems (GIS) -based approaches: logistic regression and Akaike's Information Criterion (AIC),Multiple Criteria Evaluation (MCE),and Bayesian Analysis (specifically Dempster-Shafer theory). We used lynx Lynx canadensis as our focal species,and developed our environment relationship model using track data collected in Banff National Park,Alberta,Canada,during winters from 1997 to 2000. The accuracy of the three spatial models were compared using a contingency table method. We determined the percentage of cases in which both presence and absence points were correctly classified (overall accuracy),the failure to predict a species where it occurred (omission error) and the prediction of presence where there was absence (commission error). Our overall accuracy showed the logistic regression approach was the most accurate (74.51% ). The multiple criteria evaluation was intermediate (39.22%),while the Dempster-Shafer (D-S) theory model was the poorest (29.90%). However,omission and commission error tell us a different story: logistic regression had the lowest commission error,while D-S theory produced the lowest omission error. Our results provide evidence that habitat modellers should evaluate all three error measures when ascribing confidence in their model. We suggest that for our study area at least,the logistic regression model is optimal. However,where sample size is small or the species is very rare,it may also be useful to explore and/or use a more ecologically cautious modelling approach (e.g. Dempster-Shafer) that would over-predict,protect more sites,and thereby minimize the risk of missing critical habitat in conservation plans.

  11. A statistical approach to rank multiple priorities in Environmental Epidemiology: an example from high-risk areas in Sardinia, Italy

    Directory of Open Access Journals (Sweden)

    Dolores Catelan

    2008-11-01

    Full Text Available In Environmental Epidemiology, long lists of relative risk estimates from exposed populations are compared to a reference to scrutinize the dataset for extremes. Here, inference on disease profiles for given areas, or for fixed disease population signatures, are of interest and summaries can be obtained averaging over areas or diseases. We have developed a multivariate hierarchical Bayesian approach to estimate posterior rank distributions and we show how to produce league tables of ranks with credibility intervals useful to address the above mentioned inferential problems. Applying the procedure to a real dataset from the report “Environment and Health in Sardinia (Italy” we selected 18 areas characterized by high environmental pressure for industrial, mining or military activities investigated for 29 causes of deaths among male residents. Ranking diseases highlighted the increased burdens of neoplastic (cancerous, and non-neoplastic respiratory diseases in the heavily polluted area of Portoscuso. The averaged ranks by disease over areas showed lung cancer among the three highest positions.

  12. Willingness to pay for improved respiratory and cardiovascular health: a multiple-format, stated-preference approach.

    Science.gov (United States)

    Johnson, F R; Banzhaf, M R; Desvousges, W H

    2000-06-01

    This study uses stated-preference (SP) analysis to measure willingness to pay (WTP) to reduce acute episodes of respiratory and cardiovascular ill health. The SP survey employs a modified version of the health state descriptions used in the Quality of Well Being (QWB) Index. The four health state attributes are symptom, episode duration, activity restrictions and cost. Preferences are elicited using two different SP formats: graded-pair and discrete-choice. The different formats cause subjects to focus on different evaluation strategies. Combining two elicitation formats yields more valid and robust estimates than using only one approach. Estimates of indirect utility function parameters are obtained using advanced panel econometrics for each format separately and jointly. Socio-economic differences in health preferences are modelled by allowing the marginal utility of money relative to health attributes to vary across respondents. Because the joint model captures the combined preference information provided by both elicitation formats, these model estimates are used to calculate WTP. The results demonstrate the feasibility of estimating meaningful WTP values for policy-relevant respiratory and cardiac symptoms, even from subjects who never have personally experienced these conditions. Furthermore, because WTP estimates are for individual components of health improvements, estimates can be aggregated in various ways depending upon policy needs. Thus, using generic health attributes facilitates transferring WTP estimates for benefit-cost analysis of a variety of potential health interventions.

  13. Using fuzzy multiple criteria decision-making approach for assessing the risk of railway reconstruction project in Taiwan.

    Science.gov (United States)

    Lu, Shih-Tong; Yu, Shih-Heng; Chang, Dong-Shang

    2014-01-01

    This study investigates the risk factors in railway reconstruction project through complete literature reviews on construction project risks and scrutinizing experiences and challenges of railway reconstructions in Taiwan. Based on the identified risk factors, an assessing framework based on the fuzzy multicriteria decision-making (fuzzy MCDM) approach to help construction agencies build awareness of the critical risk factors on the execution of railway reconstruction project, measure the impact and occurrence likelihood for these risk factors. Subjectivity, uncertainty and vagueness within the assessment process are dealt with using linguistic variables parameterized by trapezoid fuzzy numbers. By multiplying the degree of impact and the occurrence likelihood of risk factors, estimated severity values of each identified risk factor are determined. Based on the assessment results, the construction agencies were informed of what risks should be noticed and what they should do to avoid the risks. That is, it enables construction agencies of railway reconstruction to plan the appropriate risk responses/strategies to increase the opportunity of project success and effectiveness.

  14. A novel geotechnical/geostatistical approach for exploration and production of natural gas from multiple geologic strata, Phase 1

    Energy Technology Data Exchange (ETDEWEB)

    Overbey, W.K. Jr.; Reeves, T.K.; Salamy, S.P.; Locke, C.D.; Johnson, H.R.; Brunk, R.; Hawkins, L. (BDM Engineering Services Co., Morgantown, WV (United States))

    1991-05-01

    This research program has been designed to develop and verify a unique geostatistical approach for finding natural gas resources. The research has been conducted by Beckley College, Inc. (Beckley) and BDM Engineering Services Company (BDMESC) under contract to the US Department of Energy (DOE), Morgantown Energy Technology Center. Phase 1 of the project consisted of compiling and analyzing relevant geological and gas production information in selected areas of Raleigh County, West Virginia, ultimately narrowed to the Eccles, West Virginia, 7 {1/2} minute Quadrangle. The Phase 1 analysis identified key parameters contributing to the accumulation and production of natural gas in Raleigh County, developed analog models relating geological factors to gas production, and identified specific sites to test and verify the analysis methodologies by drilling. Based on the Phase 1 analysis, five sites have been identified with high potential for economic gas production. Phase 2 will consist of drilling, completing, and producing one or more wells at the sites identified in the Phase 1 analyses. The initial well is schedules to the drilled in April 1991. This report summarizes the results of the Phase 1 investigations. For clarity, the report has been prepared in two volumes. Volume 1 presents the Phase 1 overview; Volume 2 contains the detailed geological and production information collected and analyzed for this study.

  15. Peptide Regulation of Cofilin Activity in the CNS: A Novel Therapeutic Approach for Treatment of Multiple Neurological Disorders.

    Science.gov (United States)

    Shaw, Alisa E; Bamburg, James R

    2017-02-19

    Cofilin is a ubiquitous protein which cooperates with many other actin-binding proteins in regulating actin dynamics. Cofilin has essential functions in nervous system development including neuritogenesis, neurite elongation, growth cone pathfinding, dendritic spine formation, and the regulation of neurotransmission and spine function, components of synaptic plasticity essential for learning and memory. Cofilin's phosphoregulation is a downstream target of many transmembrane signaling processes, and its misregulation in neurons has been linked in rodent models to many different neurodegenerative and neurological disorders including Alzheimer disease (AD), aggression due to neonatal isolation, autism, manic/bipolar disorder, and sleep deprivation. Cognitive and behavioral deficits of these rodent models have been largely abrogated by modulation of cofilin activity using viral-mediated, genetic, and/or small molecule or peptide therapeutic approaches. Neuropathic pain in rats from sciatic nerve compression has also been reduced by modulating the cofilin pathway within neurons of the dorsal root ganglia. Neuroinflammation, which occurs following cerebral ischemia/reperfusion, but which also accompanies many other neurodegenerative syndromes, is markedly reduced by peptides targeting specific chemokine receptors, which also modulate cofilin activity. Thus, peptide therapeutics offer potential for cost-effective treatment of a wide variety of neurological disorders. Here we discuss some recent results from rodent models using therapeutic peptides with a surprising ability to cross the rodent blood brain barrier and alter cofilin activity in brain. We also offer suggestions as to how neuronal-specific cofilin regulation might be achieved.

  16. Robust design of multiple trailing edge flaps for helicopter vibration reduction: A multi-objective bat algorithm approach

    Science.gov (United States)

    Mallick, Rajnish; Ganguli, Ranjan; Seetharama Bhat, M.

    2015-09-01

    The objective of this study is to determine an optimal trailing edge flap configuration and flap location to achieve minimum hub vibration levels and flap actuation power simultaneously. An aeroelastic analysis of a soft in-plane four-bladed rotor is performed in conjunction with optimal control. A second-order polynomial response surface based on an orthogonal array (OA) with 3-level design describes both the objectives adequately. Two new orthogonal arrays called MGB2P-OA and MGB4P-OA are proposed to generate nonlinear response surfaces with all interaction terms for two and four parameters, respectively. A multi-objective bat algorithm (MOBA) approach is used to obtain the optimal design point for the mutually conflicting objectives. MOBA is a recently developed nature-inspired metaheuristic optimization algorithm that is based on the echolocation behaviour of bats. It is found that MOBA inspired Pareto optimal trailing edge flap design reduces vibration levels by 73% and flap actuation power by 27% in comparison with the baseline design.

  17. Hybrid approach combining multiple characterization techniques and simulations for microstructural analysis of proton exchange membrane fuel cell electrodes

    Science.gov (United States)

    Cetinbas, Firat C.; Ahluwalia, Rajesh K.; Kariuki, Nancy; De Andrade, Vincent; Fongalland, Dash; Smith, Linda; Sharman, Jonathan; Ferreira, Paulo; Rasouli, Somaye; Myers, Deborah J.

    2017-03-01

    The cost and performance of proton exchange membrane fuel cells strongly depend on the cathode electrode due to usage of expensive platinum (Pt) group metal catalyst and sluggish reaction kinetics. Development of low Pt content high performance cathodes requires comprehensive understanding of the electrode microstructure. In this study, a new approach is presented to characterize the detailed cathode electrode microstructure from nm to μm length scales by combining information from different experimental techniques. In this context, nano-scale X-ray computed tomography (nano-CT) is performed to extract the secondary pore space of the electrode. Transmission electron microscopy (TEM) is employed to determine primary C particle and Pt particle size distributions. X-ray scattering, with its ability to provide size distributions of orders of magnitude more particles than TEM, is used to confirm the TEM-determined size distributions. The number of primary pores that cannot be resolved by nano-CT is approximated using mercury intrusion porosimetry. An algorithm is developed to incorporate all these experimental data in one geometric representation. Upon validation of pore size distribution against gas adsorption and mercury intrusion porosimetry data, reconstructed ionomer size distribution is reported. In addition, transport related characteristics and effective properties are computed by performing simulations on the hybrid microstructure.

  18. Multiple approaches for the detection and characterization of viral and plasmid symbionts from a collection of marine fungi.

    Science.gov (United States)

    Nerva, L; Ciuffo, M; Vallino, M; Margaria, P; Varese, G C; Gnavi, G; Turina, M

    2016-07-02

    The number of reported mycoviruses is increasing exponentially due to the current ability to detect mycoviruses using next-generation sequencing (NGS) approaches, with a large number of viral genomes built in-silico using data from fungal transcriptome projects. We decided to screen a collection of fungi originating from a specific marine environment (associated with the seagrass Posidonia oceanica) for the presence of mycoviruses: our findings reveal a wealth of diversity among these symbionts and this complexity will require further studies to address their specific role in this ecological niche. In specific, we identified twelve new virus species belonging to nine distinct lineages: they are members of megabirnavirus, totivirus, chrysovirus, partitivirus and five still undefined clades. We showed evidence of an endogenized virus ORF, and evidence of accumulation of dsRNA from metaviridae retroviral elements. We applied different techniques for detecting the presence of mycoviruses including (i) dsRNA extraction and cDNA cloning, (ii) small and total RNA sequencing through NGS techniques, (iii) rolling circle amplification (RCA) and total DNA extraction analyses, (iv) virus purifications and electron microscopy. We tried also to critically evaluate the intrinsic value and limitations of each of these techniques. Based on the samples we could compare directly, RNAseq analysis is superior to sRNA for de novo assembly of mycoviruses. To our knowledge this is the first report on the virome of fungi isolated from marine environment. The GenBank/eMBL/DDBJ accession numbers of the sequences reported in this paper are: KT601099-KT601110; KT601114-KT601120; KT592305; KT950836-KT950841.

  19. An Integrated Modeling Framework Forecasting Ecosystem Exposure-- A Systems Approach to the Cumulative Impacts of Multiple Stressors

    Science.gov (United States)

    Johnston, J. M.

    2013-12-01

    Freshwater habitats provide fishable, swimmable and drinkable resources and are a nexus of geophysical and biological processes. These processes in turn influence the persistence and sustainability of populations, communities and ecosystems. Climate change and landuse change encompass numerous stressors of potential exposure, including the introduction of toxic contaminants, invasive species, and disease in addition to physical drivers such as temperature and hydrologic regime. A systems approach that includes the scientific and technologic basis of assessing the health of ecosystems is needed to effectively protect human health and the environment. The Integrated Environmental Modeling Framework 'iemWatersheds' has been developed as a consistent and coherent means of forecasting the cumulative impact of co-occurring stressors. The Framework consists of three facilitating technologies: Data for Environmental Modeling (D4EM) that automates the collection and standardization of input data; the Framework for Risk Assessment of Multimedia Environmental Systems (FRAMES) that manages the flow of information between linked models; and the Supercomputer for Model Uncertainty and Sensitivity Evaluation (SuperMUSE) that provides post-processing and analysis of model outputs, including uncertainty and sensitivity analysis. Five models are linked within the Framework to provide multimedia simulation capabilities for hydrology and water quality processes: the Soil Water Assessment Tool (SWAT) predicts surface water and sediment runoff and associated contaminants; the Watershed Mercury Model (WMM) predicts mercury runoff and loading to streams; the Water quality Analysis and Simulation Program (WASP) predicts water quality within the stream channel; the Habitat Suitability Index (HSI) model scores physicochemical habitat quality for individual fish species; and the Bioaccumulation and Aquatic System Simulator (BASS) predicts fish growth, population dynamics and bioaccumulation

  20. A rugged high-throughput analytical approach for the determination and quantification of multiple mycotoxins in complex feed matrices.

    Science.gov (United States)

    Dzuman, Zbynek; Zachariasova, Milena; Lacina, Ondrej; Veprikova, Zdenka; Slavikova, Petra; Hajslova, Jana

    2014-04-01

    We have developed and optimized high throughput method for reliable detection and quantification of 56 Fusarium, Alternaria, Penicillium, Aspergillus and Claviceps mycotoxins in a wide range of animal feed samples represented by cereals, complex compound feeds, extracted oilcakes, fermented silages, malt sprouts or dried distillers' grains with solubles (DDGS). From three tested extraction approaches (acetonitrile, acetonitrile/water, and QuEChERS), the QuEChERS-based method (Quick, Easy, Cheap, Effective, Rugged and Safe) was selected as the best in terms of analytes recoveries and low matrix effects. For separation and detection of target mycotoxins, method based on ultra-high performance liquid chromatography coupled with sensitive tandem mass spectrometry (U-HPLC-MS/MS) was employed. With regards to a high complexity of most of investigated feed samples, optimization of extraction/purification process was needed in the first phase to keep the method as rugged as possible. A special attention was paid to the pH of extraction solvents, especially with regard to the pH-sensitive silages. Additionally, purification of the acetonitrile extract by dispersive solid phase clean-up was assessed. Significant elimination of lipidic compounds was observed when using C18 silica sorbent. Matrix co-extracts were characterized by ultra-high performance liquid chromatography coupled with ultra-high resolution mass spectrometry (U-HPLC-HRMS). Large variability of matrix effects depending on the nature of examined feed was demonstrated in depth on a broad set of samples. Simple and unbiased strategies for their compensation were suggested.

  1. Catabolite regulation analysis of Escherichia coli for acetate overflow mechanism and co-consumption of multiple sugars based on systems biology approach using computer simulation.

    Science.gov (United States)

    Matsuoka, Yu; Shimizu, Kazuyuki

    2013-10-20

    It is quite important to understand the basic principle embedded in the main metabolism for the interpretation of the fermentation data. For this, it may be useful to understand the regulation mechanism based on systems biology approach. In the present study, we considered the perturbation analysis together with computer simulation based on the models which include the effects of global regulators on the pathway activation for the main metabolism of Escherichia coli. Main focus is the acetate overflow metabolism and the co-fermentation of multiple carbon sources. The perturbation analysis was first made to understand the nature of the feed-forward loop formed by the activation of Pyk by FDP (F1,6BP), and the feed-back loop formed by the inhibition of Pfk by PEP in the glycolysis. Those together with the effect of transcription factor Cra caused by FDP level affected the glycolysis activity. The PTS (phosphotransferase system) acts as the feed-back system by repressing the glucose uptake rate for the increase in the glucose uptake rate. It was also shown that the increased PTS flux (or glucose consumption rate) causes PEP/PYR ratio to be decreased, and EIIA-P, Cya, cAMP-Crp decreased, where cAMP-Crp in turn repressed TCA cycle and more acetate is formed. This was further verified by the detailed computer simulation. In the case of multiple carbon sources such as glucose and xylose, it was shown that the sequential utilization of carbon sources was observed for wild type, while the co-consumption of multiple carbon sources with slow consumption rates were observed for the ptsG mutant by computer simulation, and this was verified by experiments. Moreover, the effect of a specific gene knockout such as Δpyk on the metabolic characteristics was also investigated based on the computer simulation.

  2. Multiple sclerosis; Multiple Sklerose

    Energy Technology Data Exchange (ETDEWEB)

    Grunwald, I.Q.; Kuehn, A.L.; Backens, M.; Papanagiotou, P. [Universitaet des Saarlandes, Abteilung fuer Diagnostische und Interventionelle Neuroradiologie, Radiologische Klinik, Homburg/Saar (Germany); Shariat, K. [Universitaet des Saarlandes, Klinik fuer Neurochirurgie, Homburg/Saar (Germany); Kostopoulos, P. [Universitaet des Saarlandes, Klinik fuer Neurologie, Homburg/Saar (Germany)

    2008-06-15

    Multiple sclerosis is the most common chronic inflammatory disease of myelin with interspersed lesions in the white matter of the central nervous system. Magnetic resonance imaging (MRI) plays a key role in the diagnosis and monitoring of white matter diseases. This article focuses on key findings in multiple sclerosis as detected by MRI. (orig.) [German] Die Multiple Sklerose (MS) ist die haeufigste chronisch-entzuendliche Erkrankung des Myelins mit eingesprengten Laesionen im Bereich der weissen Substanz des zentralen Nervensystems. Die Magnetresonanztomographie (MRT) hat bei der Diagnosestellung und Verlaufskontrolle eine Schluesselrolle. Dieser Artikel befasst sich mit Hauptcharakteristika der MR-Bildbebung. (orig.)

  3. Summarizing EC50 estimates from multiple dose-response experiments: a comparison of a meta-analysis strategy to a mixed-effects model approach.

    Science.gov (United States)

    Jiang, Xiaoqi; Kopp-Schneider, Annette

    2014-05-01

    Dose-response studies are performed to investigate the potency of a compound. EC50 is the concentration of the compound that gives half-maximal response. Dose-response data are typically evaluated by using a log-logistic model that includes EC50 as one of the model parameters. Often, more than one experiment is carried out to determine the EC50 value for a compound, requiring summarization of EC50 estimates from a series of experiments. In this context, mixed-effects models are designed to estimate the average behavior of EC50 values over all experiments by considering the variabilities within and among experiments simultaneously. However, fitting nonlinear mixed-effects models is more complicated than in a linear situation, and convergence problems are often encountered. An alternative strategy is the application of a meta-analysis approach, which combines EC50 estimates obtained from separate log-logistic model fitting. These two proposed strategies to summarize EC50 estimates from multiple experiments are compared in a simulation study and real data example. We conclude that the meta-analysis strategy is a simple and robust method to summarize EC50 estimates from multiple experiments, especially suited in the case of a small number of experiments.

  4. Massive MIMO 多小区系统中导频污染减轻方法%Approach of pilot contamination reduction in Massive MIMO multiple cells system

    Institute of Scientific and Technical Information of China (English)

    周志超; 肖扬; 王东

    2016-01-01

    In the Massive multiple input multiple output (MIMO)multiple cells system,the reverse train-ing pilots sequences of terminals,which are from different cells,are non-orthogonal due to the reuse of these pi-lots between cells with the mode of time division duplex.The non-orthogonality of the training sequences leads to pilots contamination,which makes the forward channel estimation and pre-coding inaccuracy and blocks the improvement of the system.An approach is proposed,which is based on the cells crossed classification orthogo-nal identity and pilots power control,to reduce the pilots contamination.All the cells are classified crosswise and orthogonal identifications are distributed to the terminals and base stations in different kinds of cells.Fur-ther,terminals add the allocated identification to the head of their pilots so that the base stations can identify the sources of the received pilots.Pilots power control is applied to the terminals in the same kind of cells to reduce the influence for the base station in intersecting cells.Theory analysis and simulations results verify that the proposed approach is not only simple but also effective to alleviate pilots contamination.%Massive 多输入多输出(multiple-input multiple-output,MIMO)多小区系统时分双工(time division duplex,TDD)模式中,导频训练序列在小区间是复用的,小区间不正交的导频序列会造成严重地导频污染,从而降低信道估计和预编码的准确性,成为系统性能提升的瓶颈。针对此问题,提出基于小区交叉分类正交识别和上行导频功率控制的导频污染减轻方法。对所有小区进行交叉分类,给相邻的不同类小区分配正交的小区识别位,并把相应的识别位加到本小区终端发射的导频序列头部,使基站能够识别来自不同类小区终端的导频序列。同时控制同类小区内终端发射导频序列的功率,减少对交叉同类小区内基站的影响

  5. The utilization of an ultrasound-guided 8-gauge vacuum-assisted breast biopsy system as an innovative approach to accomplishing complete eradication of multiple bilateral breast fibroadenomas

    Directory of Open Access Journals (Sweden)

    Povoski Stephen P

    2007-10-01

    Full Text Available Abstract Background Ultrasound-guided vacuum-assisted breast biopsy technology is extremely useful for diagnostic biopsy of suspicious breast lesions and for attempted complete excision of appropriately selected presumed benign breast lesions. Case presentation A female patient presented with 16 breast lesions (eight within each breast, documented on ultrasound and all presumed to be fibroadenomas. Over a ten and one-half month period of time, 14 of these 16 breast lesions were removed under ultrasound guidance during a total of 11 separate 8-gauge Mammotome® excision procedures performed during seven separate sessions. Additionally, two of these 16 breast lesions were removed by open surgical excision. A histopathologic diagnosis of fibroadenoma and/or fibroadenomatous changes was confirmed at all lesion excision sites. Interval follow-up ultrasound imaging revealed no evidence of a residual lesion at the site of any of the 16 original breast lesions. Conclusion This report describes an innovative approach of utilizing ultrasound-guided 8-gauge vacuum-assisted breast biopsy technology for assisting in achieving complete eradication of multiple bilateral fibroadenomas in a patient who presented with 16 documented breast lesions. As such, this innovative approach is highly recommended in similar appropriately selected patients.

  6. The genetics of multiple sclerosis: review of current and emerging candidates

    Directory of Open Access Journals (Sweden)

    Muñoz-Culla M

    2013-08-01

    Full Text Available Maider Muñoz-Culla,1,2 Haritz Irizar,1,2 David Otaegui1,2 1Multiple Sclerosis Unit, Instituto Biodonostia, San Sebastián, Spain; 2Red Española de Esclerosis Múltiple (REEM, Barcelona, Spain Abstract: Multiple sclerosis (MS is a complex disease in which environmental, genetic, and epigenetic factors determine the risk of developing the disease. The human leukocyte antigen region is the strongest susceptibility locus linked to MS, but it does not explain the whole heritability of the disease. To find other non-human leukocyte antigen loci associated with the disease, high-throughput genotyping, sequencing, and gene-expression studies have been performed, producing a valuable quantity of information. An overview of the genomic and expression studies is provided in this review, as well as microRNA-expression studies, highlighting the importance of combining all the layers of information in order to elucidate the causes or pathological mechanisms occurring in the disease. Genetics in MS is a promising field that is presumably going to be very productive in the next decade understanding the cross talk between all the factors contributing to the development of MS. Keywords: multiple sclerosis, genetics, gene expression, microRNA

  7. Development of a concept for a personalized approach in the perioperative antiplatelet therapy administration/discontinuation management based on multiple electrode aggregometry in patients undergoing coronary artery surgery.

    Science.gov (United States)

    Petricevic, Mate; Milicic, Davor; White, Alexandra; Boban, Marko; Mihaljevic, Martina Zrno; Piljic, Dragan; Rotim, Ante; Buca, Ante; Mihalj, Mario; Biocina, Bojan

    2015-10-01

    In patients undergoing coronary artery surgery, improvements in clinical outcomes currently rely on continued refinements of the surgical technique and modulation of adjuvant pharmacotherapy. Despite medical and technological advances, negligible rate of bleeding and ischemic events still persist necessitating further improvements in patient management. Platelet function testing (PFT) might play an important role in meticulous balancing between the risk of bleeding and thrombotic events. A suitable balance can be achieved by implementing a personalized, PFT based approach in antiplatelet therapy (APT) administration/discontinuation management. Despite emerging evidence on the widespread variability in platelet inhibitory response to APT, numerous PFT devices and heterogeneity in reporting study results hamper pooling of the evidence which in turn results with a lack of consensus in "on treatment" platelet reactivity associated with ischemic and bleeding events in perioperative phase. The literature on multiple electrode aggregometry (Multiplate(®); Roche Diagnostics, Mannheim, Germany) in coronary artery disease patients was reviewed systematically. Based on the evidence evaluating the relationship between "drug specific" PFT and bleeding or adverse ischemic events, we sought to define therapeutic window for the most commonly administered antiplatelet drugs such as aspirin (ASPI test) and adenosine-diphosphate receptor blockers (ADP test). Preoperatively, APT administration was primarily focused to avoid bleeding complications. ASPI test value of 20 AUC and ADP test value of management would be targeted. It seems that the "one-size-fits-all" concept of perioperative APT administration management is outdated and further development of PFT based, personalized APT administration/discontinuation management is desirable. This concept therefore presents a possible step forward in patient care and provides a platform for further interventional trials whereby the impact

  8. Association of Protein Translation and Extracellular Matrix Gene Sets with Breast Cancer Metastasis: Findings Uncovered on Analysis of Multiple Publicly Available Datasets Using Individual Patient Data Approach.

    Directory of Open Access Journals (Sweden)

    Nilotpal Chowdhury

    Full Text Available Microarray analysis has revolutionized the role of genomic prognostication in breast cancer. However, most studies are single series studies, and suffer from methodological problems. We sought to use a meta-analytic approach in combining multiple publicly available datasets, while correcting for batch effects, to reach a more robust oncogenomic analysis.The aim of the present study was to find gene sets associated with distant metastasis free survival (DMFS in systemically untreated, node-negative breast cancer patients, from publicly available genomic microarray datasets.Four microarray series (having 742 patients were selected after a systematic search and combined. Cox regression for each gene was done for the combined dataset (univariate, as well as multivariate - adjusted for expression of Cell cycle related genes and for the 4 major molecular subtypes. The centre and microarray batch effects were adjusted by including them as random effects variables. The Cox regression coefficients for each analysis were then ranked and subjected to a Gene Set Enrichment Analysis (GSEA.Gene sets representing protein translation were independently negatively associated with metastasis in the Luminal A and Luminal B subtypes, but positively associated with metastasis in Basal tumors. Proteinaceous extracellular matrix (ECM gene set expression was positively associated with metastasis, after adjustment for expression of cell cycle related genes on the combined dataset. Finally, the positive association of the proliferation-related genes with metastases was confirmed.To the best of our knowledge, the results depicting mixed prognostic significance of protein translation in breast cancer subtypes are being reported for the first time. We attribute this to our study combining multiple series and performing a more robust meta-analytic Cox regression modeling on the combined dataset, thus discovering 'hidden' associations. This methodology seems to yield new and

  9. Multiple Assembly Rules Drive the Co-occurrence of Orthopteran and Plant Species in Grasslands: Combining Network, Functional and Phylogenetic Approaches

    Science.gov (United States)

    Fournier, Bertrand; Mouly, Arnaud; Gillet, François

    2016-01-01

    Understanding the factors underlying the co-occurrence of multiple species remains a challenge in ecology. Biotic interactions, environmental filtering and neutral processes are among the main mechanisms evoked to explain species co-occurrence. However, they are most often studied separately or even considered as mutually exclusive. This likely hampers a more global understanding of species assembly. Here, we investigate the general hypothesis that the structure of co-occurrence networks results from multiple assembly rules and its potential implications for grassland ecosystems. We surveyed orthopteran and plant communities in 48 permanent grasslands of the French Jura Mountains and gathered functional and phylogenetic data for all species. We constructed a network of plant and orthopteran species co-occurrences and verified whether its structure was modular or nested. We investigated the role of all species in the structure of the network (modularity and nestedness). We also investigated the assembly rules driving the structure of the plant-orthopteran co-occurrence network by using null models on species functional traits, phylogenetic relatedness and environmental conditions. We finally compared our results to abundance-based approaches. We found that the plant-orthopteran co-occurrence network had a modular organization. Community assembly rules differed among modules for plants while interactions with plants best explained the distribution of orthopterans into modules. Few species had a disproportionately high positive contribution to this modular organization and are likely to have a key importance to modulate future changes. The impact of agricultural practices was restricted to some modules (3 out of 5) suggesting that shifts in agricultural practices might not impact the entire plant-orthopteran co-occurrence network. These findings support our hypothesis that multiple assembly rules drive the modular structure of the plant-orthopteran network. This

  10. Response to heavy, non-floating oil spilled in a Great Lakes river environment: a multiple-lines-of-evidence approach for submerged oil assessment and recovery

    Science.gov (United States)

    Dollhopf, Ralph H.; Fitzpatrick, Faith A.; Kimble, Jeffrey W.; Capone, Daniel M.; Graan, Thomas P.; Zelt, Ronald B.; Johnson, Rex

    2014-01-01

    The Enbridge Line 6B pipeline release of diluted bitumen into the Kalamazoo River downstream of Marshall, MI in July 2010 is one of the largest freshwater oil spills in North American history. The unprecedented scale of impact and massive quantity of oil released required the development and implementation of new approaches for detection and recovery. At the onset of cleanup, conventional recovery techniques were employed for the initially floating oil and were successful. However, volatilization of the lighter diluent, along with mixing of the oil with sediment during flooded, turbulent river conditions caused the oil to sink and collect in natural deposition areas in the river. For more than three years after the spill, recovery of submerged oil has remained the predominant operational focus of the response. The recovery complexities for submerged oil mixed with sediment in depositional areas and long-term oil sheening along approximately 38 miles of the Kalamazoo River led to the development of a multiple-lines-of-evidence approach comprising six major components: geomorphic mapping, field assessments of submerged oil (poling), systematic tracking and mapping of oil sheen, hydrodynamic and sediment transport modeling, forensic oil chemistry, and net environmental benefit analysis. The Federal On-Scene Coordinator (FOSC) considered this information in determining the appropriate course of action for each impacted segment of the river. New sources of heavy crude oils like diluted bitumen and increasing transportation of those oils require changes in the way emergency personnel respond to oil spills in the Great Lakes and other freshwater ecosystems. Strategies to recover heavy oils must consider that the oils may suspend or sink in the water column, mix with fine-grained sediment, and accumulate in depositional areas. Early understanding of the potential fate and behavior of diluted bitumen spills when combined with timely, strong conventional recovery methods can

  11. Remielinización total en un paciente con diagnóstico de Esclerosis Múltiple remitente recurrente en tratamiento con Interferón beta 1a

    Directory of Open Access Journals (Sweden)

    María José Vargas F.

    2012-09-01

    Full Text Available INTRODUCTION: Multiple Sclerosis is a chronic demyelinatingdisease, with unknown etiology, that affect the central nervoussystem. Mainly affects women between 20 and 40 years old, andis one of the most important causes of young people disability.It happens because an autoimmune inflammatory process in thewhite matters at the central nervous system, producing demyelinatinglesions that causes the symptoms. The clinical presentationis changeable, the most frequent is the relapsing remittingform, it is marked by periods of improvement between worseningones, which in most cases is not complete. CASE REPORT:Female, 21 years old, with the diagnoses of relapsing-remittingmultiple sclerosis, that in a medical control, after six monthssince the diagnosis confirmation and the beginning of thetreatment with interferon beta 1a and without symptoms, has atotal remyelination of the injuries at the central nervous system,without pathological evidence at the magnetic resonance imaging.DISCUSSION: The remyelination of the injuries, that causethe remission of the symptoms, is usually parcial with lowerquality myelin, which is thinner and is identify by magnetic resonanceimaging as “shadow plaques”. The total remyelinationof all the injuries at the central nervous system is scantily reported,only in 2.6% of the patients, and propose that inherentfactors are involve at the myelin regeneration process, opening anew investigative line.

  12. Evaluation of Hybrid Theoretical Approaches for Structural Determination of a Glycine-Linked Cisplatin Derivative via Infrared Multiple Photon Dissociation (IRMPD) Action Spectroscopy.

    Science.gov (United States)

    He, C C; Kimutai, B; Bao, X; Hamlow, L; Zhu, Y; Strobehn, S F; Gao, J; Berden, G; Oomens, J; Chow, C S; Rodgers, M T

    2015-11-01

    To gain a better understanding of the binding mechanism and assist in the optimization of chemical probing and drug design applications, experimental and theoretical studies of a series of amino acid-linked cisplatin derivatives are being pursued. Glyplatin (glycine-linked cisplatin) was chosen for its structural simplicity and to enable backbone effects to be separated from side-chain effects on the structure and reactivity of ornithine- and lysine-linked cisplatin (Ornplatin and Lysplatin, respectively). Infrared multiple photon dissociation (IRMPD) action spectroscopy experiments were performed on Glyplatin to characterize its structure and guide the selection of the most effective hybrid theoretical approach for determining its structure and IR spectrum. The simplicity of the Glyplatin system allows a wide variety of density functionals, treatments of the Pt center including the use of all-electron basis sets vs valence basis sets combined with an effective core potential (ECP), and basis sets for all other atoms to be evaluated at a reasonable computational cost. The results for Glyplatin provide the foundation for calculations of more complex amino acid-linked cisplatin derivatives such as Ornplatin and Lysplatin. Present results suggest that the B3LYP/mDZP/def2-TZVP hybrid method can be effectively employed for structural and IR characterization of more complex amino acid-linked cisplatin complexes and their nucleic acid derivatives.

  13. An improved approach for measuring the impact of multiple CO2 conductances on the apparent photorespiratory CO2 compensation point through slope-intercept regression.

    Science.gov (United States)

    Walker, Berkley J; Skabelund, Dane C; Busch, Florian A; Ort, Donald R

    2016-06-01

    Biochemical models of leaf photosynthesis, which are essential for understanding the impact of photosynthesis to changing environments, depend on accurate parameterizations. One such parameter, the photorespiratory CO2 compensation point can be measured from the intersection of several CO2 response curves measured under sub-saturating illumination. However, determining the actual intersection while accounting for experimental noise can be challenging. Additionally, leaf photosynthesis model outcomes are sensitive to the diffusion paths of CO2 released from the mitochondria. This diffusion path of CO2 includes both chloroplastic as well as cell wall resistances to CO2 , which are not readily measurable. Both the difficulties of determining the photorespiratory CO2 compensation point and the impact of multiple intercellular resistances to CO2 can be addressed through application of slope-intercept regression. This technical report summarizes an improved framework for implementing slope-intercept regression to evaluate measurements of the photorespiratory CO2 compensation point. This approach extends past work to include the cases of both Rubisco and Ribulose-1,5-bisphosphate (RuBP)-limited photosynthesis. This report further presents two interactive graphical applications and a spreadsheet-based tool to allow users to apply slope-intercept theory to their data.

  14. A novel clinical approach for long-term retention and durability of resin restorations bonded to multiple developmental defects of enamel

    Science.gov (United States)

    Harika, Rapala; Dutta, Brahmananda; Arun, Parsa; Teja, Raveen P.

    2016-01-01

    Dental enamel is a unique, highly mineralized tissue of ectodermal origin. It is characterized by lack of metabolic activity once formed, implying that disturbances during development can manifest as permanent defects in the erupted tooth. Although the etiology of enamel defects may be attributed to local, systemic, genetic, or environmental factors, most are likely to be multifactorial in nature. The time frame of exposure and the mechanism underpinning the causative factors determine the presentation of these defects. These developmental defects of enamel (DDE) may range from slight abnormalities of the tooth's color to a complete absence of the enamel, some of which may be sensed by an individual as being disfiguring and call for treatment to improve the appearance of the dentition. Molar incisor hypomineralization (MIH) is a relatively common condition that varies in clinical severity, remains localized to permanent incisors and first permanent molars, and whose prevalence varies between 2.8 and 25% depending upon the study. Adhesion and retention of resin restorations is challenging in long-term rehabilitation in these cases. This paper presents a novel approach in the functional and esthetic rehabilitation of a 13-year-old female child diagnosed with multiple DDEs. PMID:28032054

  15. Modelo de oposições múltiplas modificado: abordagem baseada em traços distintivos Modified multiple oppositions' model: approach based on distinctive features

    Directory of Open Access Journals (Sweden)

    Karina Carlesso Pagliarin

    2009-01-01

    Full Text Available O objetivo deste trabalho foi propor uma abordagem com enfoque em traços distintivos para o Modelo de Oposições Múltiplas e testar sua aplicação em um sujeito falante do Português Brasileiro. O Modelo foi aplicado em um sujeito do sexo masculino, com desvio fonológico moderado-severo e idade de seis anos e meio. Após avaliação fonológica, procedeu-se à seleção dos sons-alvo. Considerou-se o sistema fonológico inicial, bem como os traços distintivos alterados ([+voz], [+soante], [+aproximante], [coronal/±anterior], [-contínuo]. Os traços com maior número de alterações eram [+voz, +soante, +aproximante], justificando a escolha dos seguintes sons-alvo para tratamento: /r/ x /l/ x // x // x /z/, em onset medial.Tendo como base a aplicação desse modelo em falantes do inglês, percebeu-se a necessidade de introduzir alguns procedimentos, como: a escolha dos sons-alvo a partir dos traços distintivos alterados e a estrutura da sessão terapêutica. Ao final, o sujeito foi reavaliado a fim de verificar as aquisições no sistema fonológico. Após dez sessões de fonoterapia,o sujeito adquiriu os fonemas /l, , , z/, generalizando-os para outras posições na palavra (/Z/ e /l/ em onset inicial. Verificou-se, também, a ocorrência de generalização para a mesma classe e para outras classes de sons (/b/, /d/, /g/, /v/. No entanto, o fonema /r/ não foi adquirido. Esta proposta mostrou-se efetiva, pois o sujeito apresentou melhora em seu sistema fonológico com poucas sessões terapêuticas. Pôde-se observar que o Modelo de Oposições Múltiplas, utilizando a abordagem com base em traços distintivos é eficaz, pois favoreceu diversas mudanças fonológicas.The aim of this study was to propose an approach based on distinctive features for the Multiple Oppositions Model, and to test its application on a Brazilian Portuguese speaker. The model was used with a male subject with moderate-severe phonological disorder and six years

  16. Orchestrating Multiple Intelligences

    Science.gov (United States)

    Moran, Seana; Kornhaber, Mindy; Gardner, Howard

    2006-01-01

    Education policymakers often go astray when they attempt to integrate multiple intelligences theory into schools, according to the originator of the theory, Howard Gardner, and his colleagues. The greatest potential of a multiple intelligences approach to education grows from the concept of a profile of intelligences. Each learner's intelligence…

  17. Dimensión respiratoria de la escala ALSFRS-R y la función respiratoria en la esclerosis lateral amiotrófica Respiratory domain of revised amyotrophic lateral sclerosis: Functional Rating Scale

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    Sandra E. Lima

    2009-10-01

    Full Text Available Virtualmente todos los pacientes con esclerosis lateral amiotrófica tendrán disnea, que es quizá el síntoma más penoso de esta devastadora enfermedad. El objetivo de este estudio fue correlacionar la dimensión respiratoria de la escala ALSFRS-R, la capacidad vital forzada y las presiones estáticas máximas bucales. Se estudiaron prospectivamente 20 pacientes consecutivos sin disnea durante 24 meses. El puntaje total de la escala ALSFRS-R disminuyó de 34.3 ± 10.3 a 22.1 ± 8.0 (p = 0.0325; la contribución de la dimensión respiratoria fue insignificante. En quienes refirieron disnea (n: 12, la capacidad vital forzada cayó un 41 ± 21 % del valor inicial pero con similar caída (46 ± 23%, 8 pacientes no refirieron disnea. La correlación entre la escala ALSFRS-R con la capacidad vital forzada (litros fue r: 0.73, (p = 0.0016 y con la presión inspiratoria máxima (cm H2O, r: 0.84, p = 0.0038. La correlación entre la capacidad vital forzada (% con la disnea fue r s: 0.23, p = 0.1400. La correlación de la disnea con la presión inspiratoria máxima (% fue r s: 0.58, p = 0.0300 y con la presión espiratoria máxima (%, r s: 0.49, p = 0.0400. La dimensión respiratoria de la escala ALSFRS-R no permitió predecir el grado de deterioro funcional respiratorio. Esto sugiere que dicha dimensión no reemplaza a las mediciones funcionales respiratorias y, debido a que la insuficiencia respiratoria puede no ser evidente, la realización de dichas pruebas provee una base objetiva de seguimiento y permite planear medidas con anticipación.Virtually all patients with amyotrophic lateral sclerosis will complain of dyspnea, which is perhaps the most distressing symptom of this devastating disease. The objective was to correlate respiratory domain of ALSFRS-R with forced vital capacity and maximal static pressures in the mouth. We designed a prospective study in 20 consecutive patients without dyspnea during 24 months. The global decline of ALSFRS

  18. Outcome of sporadic amyotrophic lateral sclerosis treated With non-invasive ventilation and riluzole Sobrevida en pacientes con esclerosis lateral amiotrófica esporádica tratados con ventilación no invasiva y riluzole

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    Martín Sívori

    2007-08-01

    Full Text Available Sporadic amyotrophic lateral sclerosis (sALS is a progressive degenerative motor neuron disorder lacking specific treatment. Riluzole is the only drug able to modestly slow down the course of the disease. Respiratory insufficiency is the main cause of death; non invasive ventilation (NIV has shown to improve survival. Our aim was to evaluate the effect of NIV and riluzole on survival. Ninety seven patients with a diagnosis of sALS were assessed and followed up for 60 months. Twenty nine patients received NIV and 68 did not (nNIV. Overall median survival In the NIV group was 15.41 ± 7.78 months vs. 10.88 ± 7.78 months in the nNIV group (p= 0.028. Median survival time was not different in patients receiving riluzole (n=44, as compared with those who did not (n=53, although at month 4th and 5th riluzole treated patients showed a modest benefit. In those who only received NIV (n=11 or only riluzole (n=26, survival time was 13.45 ± 13.44 months and 11.19 ± 7.79 months, respectively. Patients who received both NIV and riluzole (n=18 had a median survival time of 16.61 ± 10.97 months vs. 10.69 ± 7.86 months for those who received only supportive treatment (n=42 (p= 0.021. NIV improved survival in our series of patients. Riluzole did not show any significant impact on survival when employed as the only therapy. Patients receiving both treatments simultaneously had a significant longer survival.La esclerosis lateral amiotrófica esporádica (sALS es una enfermedad degenerativa para la que no existe tratamiento etiológico eficaz. El riluzole prolonga poco la sobrevida. La principal causa de muerte es la insuficiencia respiratoria. Uno de los tratamientos para esta última es la ventilación asistida no invasiva (NIV con equipos de doble nivel de presión. El objetivo de este trabajo fue determinar el impacto en la sobrevida de estos enfermos combinando ventilación no invasiva y riluzole. Se evaluaron y siguieron durante 60 meses 97 pacientes con

  19. Complejo nódulo subependimario-astrocitoma subependimario gigantocelular en niños con esclerosis tuberosa Subependymal nodules-subependymal giant cell astrocytoma complex in children with tuberous sclerosis

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    Lucas Bongiorni

    2009-01-01

    Full Text Available El objetivo fue describir las características clínico imagenológicas de niños con esclerosis tuberosa que presentaron el complejo Nódulo Subependimario (NS-Astrocitoma Subependimario Gigantocelular(ASGC y analizar el comportamiento evolutivo de dicho "complejo" para detectar precozmente su crecimiento y evitar las complicaciones de la hipertensión endocraneana (HTE. Evaluamos 22 pacientes con diagnóstico anátomo patológico de ASGC. El diagnóstico del tumor se realizó a una media de 10.1 años. Pudimos observar la evolución de NS a ASGC; estos NS se ubicaron adyacentes al agujero de Monro y con el tiempo tuvieron un importante crecimiento con intensa captación de contraste e hidrocefalia. La aceleración en el crecimiento de estos NS y su "transformación" en ASGC se produjo a los 10 años de edad promedio, con un diámetro medio de 9 mm. Ningún NS alejado de los forámenes de Monro evolucionó a ASGC. Quince pacientes (68% fueron operados con síntomas de hipertensión endocraneana. La edad media de la cirugía fue 10.8 años. Seis pacientes presentaron déficit visual. En estos últimos, el diámetro medio mayor del tumor fue 31.5 mm, mayor que los 18.7 mm del grupo de pacientes que no presentó secuela visual. El seguimiento clínico imagenológico periódico de toda lesión subependimaria próxima a los agujeros de Monro, permitiría en etapa presintomática anticipar un tratamiento quirúrgico, que reduciría la incidencia de HTE. Estudios prospectivos podrían determinar si el complejo NS-ASGC corresponde a una misma entidad en distinta etapa evolutiva, o son dos lesiones con diferente potencial de crecimiento.The object of this paper is to describe the imaging and clinical characteristics of subependymal nodule (SN - subependymal giant cell astrocytoma (SGCA complex in tuberous sclerosis and analyze its evolution in order to attempt early detection and the prevention of intracranial hypertension. We evaluated 22 patients with

  20. [Prevalence of multiple sclerosis in the Region of Murcia].

    Science.gov (United States)

    Carreon-Guarnizo, E; Andreu-Reinon, E; Cerdan-Sanchez, M; Carrasco-Torres, R; Hernandez-Clares, R; Prieto-Valiente, L; Garcia-Escriba, C; Sola-Roca, A; Martinez-Andreu, M E; Miralles Gonzalez-Conde, M A; Martin-Fernandez, J J; Meca-Lallana, J E

    2016-05-01

    Introduccion. La esclerosis multiple (EM) es una enfermedad inflamatoria desmielinizante del sistema nervioso central con patogenia inmunomediada. Recientes estudios indican un aumento de su prevalencia, y numerosos trabajos relacionan el virus de Epstein-Barr (VEB) con su etiologia. Objetivo. Analisis de prevalencia de la EM en la Region de Murcia, incluyendo la descripcion de las caracteristicas clinicas en el momento del inicio de la enfermedad, y del estado serologico del VEB de los pacientes con EM. Pacientes y metodos. Estudio epidemiologico retrospectivo, tomando como muestra la poblacion residente en el area sanitaria centro-oeste de la Region de Murcia (257.865 habitantes). Se analizan datos clinicos y serologicos extraidos de diferentes fuentes. Resultados. Prevalencia de la EM en la poblacion estudiada: 88 casos/100.000 habitantes. Prevalencia de la EM junto con el sindrome desmielinizante aislado: 98,4 casos/100.000 habitantes. Incidencia media de la EM: 5,8 casos/100.000 habitantes/año. En el inicio de la EM, el 67,8% eran mujeres, el 81,9% presentaba un curso recurrente-remitente, la edad media era de 31,4 años, el sistema funcional mas frecuentemente afectado era el sensitivo (45,1%), el inicio fue monofocal en el 55,4% y el grado de discapacidad en la Expanded Disability Status Scale era de 2,1 puntos. La seroprevalencia del VEB fue del 99,3%. La reactivacion de la infeccion por VEB se relaciono con actividad clinica de EM en 10 pacientes (45,4%). Conclusiones. Actualmente, la prevalencia de la EM en la Region de Murcia es similar a la estimada en otras comunidades autonomas españolas. El estudio confirma la tendencia de incremento de prevalencia observada en las ultimas decadas.