WorldWideScience

Sample records for applying design principles

  1. Universal Design for Online Courses: Applying Principles to Pedagogy

    Science.gov (United States)

    Rao, Kavita; Edelen-Smith, Patricia; Wailehua, Cat-Uyen

    2015-01-01

    Universal design (UD) educational frameworks provide useful guidelines for designing accessible learning environments with the intention of supporting students with and without disabilities. This article describes how one university instructor defined and applied the principles of Universal Instructional Design (UID) to pedagogy, while designing…

  2. Ergonomics and design: its principles applied in the industry.

    Science.gov (United States)

    Tavares, Ademario Santos; Silva, Francisco Nilson da

    2012-01-01

    Industrial Design encompasses both product development and optimization of production process. In this sense, Ergonomics plays a fundamental role, because its principles, methods and techniques can help operators to carry out their tasks most successfully. A case study carried out in an industry shows that the interaction among Design, Production Engineering and Materials Engineering departments may improve some aspects concerned security, comfort, efficiency and performance. In this process, Ergonomics had shown to be of essential importance to strategic decision making to the improvement of production section.

  3. Accessible by Design: Applying UDL Principles in a First Year Undergraduate Course

    Science.gov (United States)

    Kumar, Kari Lynne; Wideman, Maureen

    2014-01-01

    This article presents a case study of a technology-enhanced face-to-face health sciences course in which the principles of Universal Design for Learning (UDL) were applied. Students were offered a variety of means of representation, engagement, and expression throughout the course, and were surveyed and interviewed at the end of the term to…

  4. Sign Redesign: Applying Design Principles to Improve Signage in an Academic Library

    Directory of Open Access Journals (Sweden)

    Sheila Kasperek

    2014-05-01

    Full Text Available When the Mansfield University library’s Special Events and Customer Service Committee created a communications plan for the library, the opportunity presented itself to overhaul the library signs. Applying basic design principles of contrast, alignment, and repetition along with standards from the Americans with Disabilities Act, the library improved the visual communications within the library. Patrons can now read signs from a distance and understand their purpose. Using common design elements, the library began presenting official library information more cohesively. Extending beyond signs, these design principles are now part of the library’s print publications and promotional items. With this consistency, the library brand is more easily recognizable both within the library and across campus. This article describes some basic elements of design and the process of redesigning the signs.

  5. A Study of the Effectiveness of Information Design Principles Applied to Clinical Research Questionnaires.

    Science.gov (United States)

    Zimmerman, Beverly B.; Schultz, Jessica R.

    2000-01-01

    Investigates the effectiveness of information design principles and feedback-based usability testing in developing clinical questionnaires. Finds that a form developed using information design principles collected significantly more data than did a control form. (SR)

  6. 41 CFR 102-76.55 - What sustainable development principles must Federal agencies apply to the siting, design, and...

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What sustainable... and Construction Sustainable Development § 102-76.55 What sustainable development principles must... Acquisition,” Federal agencies must apply sustainable development principles to the siting, design,...

  7. Workspace Design: A case study applying participatory design principles of healthy workplaces in an industrial setting

    DEFF Research Database (Denmark)

    Broberg, Ole

    2010-01-01

    in a case involving the design and implementation of a new mixing technology in an industrial plant. The case showed how the WSD concept can contribute to an engineering design process. The WSD team took the role as workspace designer and by the participatory workshops achieved an impact on the technology......The Danish Workspace Design (WSD) research program is aimed to develop and trial a potential new concept for ergonomists and other workplace consultants who are to engage in socio-technical design processes. The objective of this paper is to report on the trial of the workspace design concept...... project. In the role as workspace designer it was important for the WSD team to make sure that the achievements in the workshops were “transmitted” to and sustained in the ordinary engineering design process. In this case, it turned out that the artefacts such as a layout game board and documents...

  8. HIGH QUALITY ENVIRONMENTAL PRINCIPLES APPLIED TO THE ARCHITECTONIC DESIGN SELECTION PROCEDURE: THE NUTRE LAB CASE

    Directory of Open Access Journals (Sweden)

    Claudia Barroso Krause

    2012-06-01

    Full Text Available The need to produce more sustainable buildings has been influencing the design decisions all over the world. That’s why it is imperative, in Brazil, the development of strategies and method to aid the decision making during the design process, focused on high quality environmental. This paper presents a decision support tool based on the principles of sustainable construction developed by the Project, Architecture and Sustainability Research Group (GPAS of Federal University of Rio de Janeiro – Brazil. The methodology has been developed for the selection of a preliminary design of a laboratory to be built at Rio Technology Park at the University campus. The support provided by GPAS occurred in three stages: the elaboration of the Reference Guide for the competitors, the development of a methodology to evaluate the proposed solutions (based on environmental performance criteria and the assistance of the members of jury in the trial phase. The theoretical framework was based upon the concepts of the bioclimatic architecture, the procedures specified by the certification HQE® (Haute Qualité Environnementale and the method suggested by the ADDENDA® architecture office. The success of this experience points out the possibility to future application in similar cases.

  9. Applying the Principles of Project Management to a Collegiate Automotive Engineering Design Project

    OpenAIRE

    Dvorkin, William Nathan

    2016-01-01

    The Hybrid Electric Vehicle Team of Virginia Tech is a collegiate automotive engineering design team that reengineers production vehicles to reduce environmental impact while maintaining vehicle marketability. The team Project Manager is responsible for coordinating high-level management and planning activities with the goal of better aligning the team with business and automotive industry practices. Project management responsibilities within the Hybrid Electric Vehicle Team are divided into ...

  10. Aesthetic Principles for Instructional Design

    Science.gov (United States)

    Parrish, Patrick E.

    2009-01-01

    This article offers principles that contribute to developing the aesthetics of instructional design. Rather than describing merely the surface qualities of things and events, the concept of aesthetics as applied here pertains to heightened, integral experience. Aesthetic experiences are those that are immersive, infused with meaning, and felt as…

  11. RFID design principles

    CERN Document Server

    Lehpamer, Harvey

    2012-01-01

    This revised edition of the Artech House bestseller, RFID Design Principles, serves as an up-to-date and comprehensive introduction to the subject. The second edition features numerous updates and brand new and expanded material on emerging topics such as the medical applications of RFID and new ethical challenges in the field. This practical book offers you a detailed understanding of RFID design essentials, key applications, and important management issues. The book explores the role of RFID technology in supply chain management, intelligent building design, transportation systems, military

  12. Fundamental Principles of Alarm Design

    DEFF Research Database (Denmark)

    Us, Tolga; Jensen, Niels; Lind, Morten;

    2011-01-01

    Traditionally alarms are designed on the basis of empirical guidelines rather than on a sound scientific framework rooted in a theoretical foundation for process and control system design. This paper proposes scientific principles and a methodology for design of alarms based on a functional...... be applied to any engineering system which can be modeled by MFM. The methodology provides a set of alarms which can facilitate event interpretation and operator support for abnormal situation management. The proposed design methodology provides the information content of the alarms, but does not deal...

  13. Applying quantum principles to psychology

    International Nuclear Information System (INIS)

    This article starts out with a detailed example illustrating the utility of applying quantum probability to psychology. Then it describes several alternative mathematical methods for mapping fundamental quantum concepts (such as state preparation, measurement, state evolution) to fundamental psychological concepts (such as stimulus, response, information processing). For state preparation, we consider both pure states and densities with mixtures. For measurement, we consider projective measurements and positive operator valued measurements. The advantages and disadvantages of each method with respect to applications in psychology are discussed. (paper)

  14. Principles of smile design

    Directory of Open Access Journals (Sweden)

    Bhuvaneswaran Mohan

    2010-01-01

    Full Text Available An organized and systematic approach is required to evaluate, diagnose and resolve esthetic problems predictably. It is of prime importance that the final result is not dependent only on the looks alone. Our ultimate goal as clinicians is to achieve pleasing composition in the smile by creating an arrangement of various esthetic elements. This article reviews the various principles that govern the art of smile designing. The literature search was done using PubMed search and Medline. This article will provide a basic knowledge to the reader to bring out a functional stable smile.

  15. Principles of smile design.

    Science.gov (United States)

    Bhuvaneswaran, Mohan

    2010-10-01

    An organized and systematic approach is required to evaluate, diagnose and resolve esthetic problems predictably. It is of prime importance that the final result is not dependent only on the looks alone. Our ultimate goal as clinicians is to achieve pleasing composition in the smile by creating an arrangement of various esthetic elements. This article reviews the various principles that govern the art of smile designing. The literature search was done using PubMed search and Medline. This article will provide a basic knowledge to the reader to bring out a functional stable smile.

  16. Universal Instructional Design Principles for Mobile Learning

    Science.gov (United States)

    Elias, Tanya

    2011-01-01

    The report extends a previous analysis of universal instructional design principles in distance education by applying them to the design of mobile learning. Eight principles with particular relevance for distance education are selected, and their recommendations are discussed in relation to the design of educational materials for a range of mobile…

  17. Deriving and applying generally applicable safety principles

    Energy Technology Data Exchange (ETDEWEB)

    Spray, S.D.

    1998-08-01

    The nuclear detonation safety of modern nuclear weapons depends on a coordinated safety theme incorporating three general safety principles: isolation, inoperability, and incompatibility. The success of this approach has encouraged them to study whether these and/or other principles might be useful in other applications. Not surprisingly, no additional first-principles (based on physical laws) have been identified. However, a more widely applicable definition and application of the principle-based approach has been developed, resulting in a selection of strategies that are basically subsets and varied combinations of the more general principles above. However, identification of principles to be relied on is only one step in providing a safe design. As one other important example, coordinating overall architecture and strategy is essential: the authors term this a safety theme.

  18. What Metadata Principles Apply to Scientific Data?

    Science.gov (United States)

    Mayernik, M. S.

    2014-12-01

    Information researchers and professionals based in the library and information science fields often approach their work through developing and applying defined sets of principles. For example, for over 100 years, the evolution of library cataloging practice has largely been driven by debates (which are still ongoing) about the fundamental principles of cataloging and how those principles should manifest in rules for cataloging. Similarly, the development of archival research and practices over the past century has proceeded hand-in-hand with the emergence of principles of archival arrangement and description, such as maintaining the original order of records and documenting provenance. This project examines principles related to the creation of metadata for scientific data. The presentation will outline: 1) how understandings and implementations of metadata can range broadly depending on the institutional context, and 2) how metadata principles developed by the library and information science community might apply to metadata developments for scientific data. The development and formalization of such principles would contribute to the development of metadata practices and standards in a wide range of institutions, including data repositories, libraries, and research centers. Shared metadata principles would potentially be useful in streamlining data discovery and integration, and would also benefit the growing efforts to formalize data curation education.

  19. Simplified energy design economics: principles of economics applied to energy conservation and solar energy investments in buildings

    Energy Technology Data Exchange (ETDEWEB)

    Marshall, H.E.; Ruegg, R.T.

    1980-01-01

    A guide to basic economic concepts and tools for solving simple economic problems in energy conservation and for understanding complex problems is provided. The concepts of economic efficiency are discussed, followed by a discussion of the basic principles of economics required to comprehend the economic evaluations of alternative investment decisions. Step-by-step procedures for evaluating the economic desirability of alternative investments are presented to illustrate and reinforce an understanding of the principles. Five tools of economic analysis discussed are: life-cycle cost, net benefits or savings, savings-to-investment ratio, internal rate of return, and discounted payback. A solar energy system with a conventional backup system is evaluated for cost effectiveness against a conventional energy system used alone using the five tools. Factors affecting benefits and costs discussed are: discount rate, incentives, inflation, salvage value, taxes, time horizon, and uncertainty. A glossary, discount formulas and factors, and uniform present worth factors modified for energy price escalation are covered in appendices. (MCW)

  20. Applying Software Engineering Principles to Process Modeling

    OpenAIRE

    Henry, Joel

    1992-01-01

    Process models are constructed using specific modeling methods or techniques. These techniques impart certain characteristics to the models they produce. Application of the software engineering principles of information hiding, top-down functional decomposition and stepwise refinement to process modeling imparts many desirable characteristics to the process models produced. This paper describes an approach to process modeling which applies these software engineering principles to control flow...

  1. Universal Instructional Design Principles for Mobile Learning

    OpenAIRE

    Tanya Elias

    2011-01-01

    The report extends a previous analysis of universal instructional design principles in distance education by applying them to the design of mobile learning. Eight principles with particular relevance for distance education are selected, and their recommendations are discussed in relation to the design of educational materials for a range of mobile devices. The problems and opportunities of mobile learning are discussed as is the need for educators to focus on content design issues rather th...

  2. Education and training for advanced practice: Principles of course design and assessment applied to a 'stereotactic needle core biopsy of the breast' module

    International Nuclear Information System (INIS)

    In order to realise the promise of the NHS Plan, radiographers are extending their practice to encompass tasks previously undertaken by radiologists and advancing their practice by taking responsibility for clinical decision-making and autonomous membership of multidisciplinary healthcare teams. In partnership with clinical service providers Higher Education Institutes are devising programmes of study to support such professional development. This article reviews the design of a 20 credit post-graduate (M level) module in stereotactic needle core biopsy of the breast. Particular consideration is given to underpinning educational principles of course design and assessment and how these are applied in order that teaching, learning and assessment have academic rigour and clinical competence of successful students is assured

  3. Education and training for advanced practice: Principles of course design and assessment applied to a 'stereotactic needle core biopsy of the breast' module

    Energy Technology Data Exchange (ETDEWEB)

    Dixon, Anne-Marie [Division of Radiography, University of Bradford, Bradford BD5 0BB (United Kingdom)]. E-mail: a.m.dixon@bradford.ac.uk

    2006-05-15

    In order to realise the promise of the NHS Plan, radiographers are extending their practice to encompass tasks previously undertaken by radiologists and advancing their practice by taking responsibility for clinical decision-making and autonomous membership of multidisciplinary healthcare teams. In partnership with clinical service providers Higher Education Institutes are devising programmes of study to support such professional development. This article reviews the design of a 20 credit post-graduate (M level) module in stereotactic needle core biopsy of the breast. Particular consideration is given to underpinning educational principles of course design and assessment and how these are applied in order that teaching, learning and assessment have academic rigour and clinical competence of successful students is assured.

  4. Simplified energy design economics: principles of economics applied to energy conservation and solar energy investments in buildings. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Marshall, H.E.; Ruegg, R.T.; Wilson, F.

    1980-01-01

    This handbook introduces the architect and engineer to economic analysis techniques for evaluating alternative energy conservation investments in buildings. Life-cycle cost, benefit-cost, savings-to-investment, payback, and rate-of-return analyses are explained and illustrated. The procedure for discounting is described for a heat pump investment. Formulas, tables of discount factors, and detailed instructions are provided to give the reader all information required to make economic evaluations of energy conserving building designs.

  5. Simplified energy design economics: Principles of economics applied to energy conservation and solar energy investments in buildings

    Science.gov (United States)

    Marshall, H. E.; Ruegg, R. T.; Wilson, F.

    1980-01-01

    Economic analysis techniques for evaluating alternative energy conservation investments in buildings are presented. Life cycle cost, benefit cost, savings to investment, payback, and rate of return analyses are explained and illustrated. The procedure for discounting is described for a heat pump investment. Formulas, tables of discount factors, and detailed instructions are provided to give all information required to make economic evaluations of energy conserving building designs.

  6. Applying Connectivist Principles and the Task-Based Approach to the Design of a Multimodal Didactic Unit

    Directory of Open Access Journals (Sweden)

    Yeraldine Aldana Gutiérrez

    2012-12-01

    Full Text Available This article describes the pedagogical intervention developed in a public school as part of the research “Exploring Communications Practices through Facebook as a Mediatic Device”, framed within the computer mediated communications field. Twelve ninth graders’ communications practices were explored and addressed by means of multimodal technological resources and tasks based on the connectivist learning view. As a result, a didactic unit was designed in the form of the digital book Diverface. This one in turn displayed information through different media channels and semiotic elements to support its multimodal features. Teachers and students might thus need to reconstruct an alternative multimodal literacy so that they can produce and interpret texts of the same nature in online environments.

  7. Logical database design principles

    CERN Document Server

    Garmany, John; Clark, Terry

    2005-01-01

    INTRODUCTION TO LOGICAL DATABASE DESIGNUnderstanding a Database Database Architectures Relational Databases Creating the Database System Development Life Cycle (SDLC)Systems Planning: Assessment and Feasibility System Analysis: RequirementsSystem Analysis: Requirements Checklist Models Tracking and Schedules Design Modeling Functional Decomposition DiagramData Flow Diagrams Data Dictionary Logical Structures and Decision Trees System Design: LogicalSYSTEM DESIGN AND IMPLEMENTATION The ER ApproachEntities and Entity Types Attribute Domains AttributesSet-Valued AttributesWeak Entities Constraint

  8. Study of Screen Design Principles for Visualizing Medical Records.

    Science.gov (United States)

    Fujita, Kenichiro; Takemura, Tadamasa; Kuroda, Tomohiro

    2015-01-01

    To improve UX of EMR/EHR, the screen design principles for the visualization are required. Through the study of common attributes of medical records, we present four principles and show three screen designs by applying them.

  9. Initial Design principles

    OpenAIRE

    Jensen, Thomas; Vatrapu, Ravi

    2015-01-01

    This paper presents a design science approach to solving persistent problems in the international shipping eco system by creating the missing common information infrastructures. Specifically, this paper reports on an ongoing dialogue between stakeholders in the shipping industry and information systems researchers engaged in the design and development of a prototype for an innovative IT-artifact called Shipping Information Pipeline which is a kind of “an internet” for shipping information. Th...

  10. Applied Control Systems Design

    CERN Document Server

    Mahmoud, Magdi S

    2012-01-01

    Applied Control System Design examines several methods for building up systems models based on real experimental data from typical industrial processes and incorporating system identification techniques. The text takes a comparative approach to the models derived in this way judging their suitability for use in different systems and under different operational circumstances. A broad spectrum of control methods including various forms of filtering, feedback and feedforward control is applied to the models and the guidelines derived from the closed-loop responses are then composed into a concrete self-tested recipe to serve as a check-list for industrial engineers or control designers. System identification and control design are given equal weight in model derivation and testing to reflect their equality of importance in the proper design and optimization of high-performance control systems. Readers’ assimilation of the material discussed is assisted by the provision of problems and examples. Most of these e...

  11. Universal Instructional Design Principles for Mobile Learning

    Directory of Open Access Journals (Sweden)

    Tanya Elias

    2011-02-01

    Full Text Available The report extends a previous analysis of universal instructional design principles in distance education by applying them to the design of mobile learning. Eight principles with particular relevance for distance education are selected, and their recommendations are discussed in relation to the design of educational materials for a range of mobile devices. The problems and opportunities of mobile learning are discussed as is the need for educators to focus on content design issues rather than on searching for the next new technology.

  12. Applying Critical Scandinavian ISD research principles in an African Context

    DEFF Research Database (Denmark)

    Mengiste, Shegaw Anagaw; Tjørnehøj, Gitte

    2013-01-01

    these countries have a vast need for the technology to develop their economies and living standards. We investigate opportunities of applying Scandinavian principles for ISD&I in the context of Africa, through analyzing and comparing two action research projects that have applied two classic approaches; The Trade...... Unionist (TU) and the Activity Theory approach. We focus specifically on the principles of participation, empowerment, and evolutionary design and discuss how they can help mitigate the challenges, create opportunities and exploit possibilities of ISD&I in this context. Based on this we argue how and why...

  13. The principles of garden design

    OpenAIRE

    Turner, Tom

    2008-01-01

    This ebook explains the 3 classic design principles: gardens should be useful, gardens should be well-made and gardens should be beautiful. They derive from Vitruvius and have influenced the design of gardens since ancient times and are as important today as they have always been.

  14. Structuring Principles for the Designer

    DEFF Research Database (Denmark)

    Miller, Thomas Dedenroth; Pedersen, Per Erik Elgård

    1998-01-01

    This paper suggests a list of structuring principles that support the designer in making alternative concepts for product architectures. Different architectures may support different points of diversification in the product life-cycle. The aim is to balance reuse of resources and reduction...... of variability in design processes and manufacturing processes with product performance and unit costs....

  15. Principles and Criteria for Design

    DEFF Research Database (Denmark)

    Beghin, D.; Cervetto, D.; Hansen, Peter Friis

    1997-01-01

    The mandate of ISSC Committee IV.1 on principles and Criteria for Design is to report on the following:The ongoing concern for quantification of general economic and safety criteria for marine structures and for the development of appropriate principles for rational life cycle design using...... such criteria. Reassessment of existing structures shall also be addressed. Special attention shall be given to issues affecting code formulation and development, with accounting of all uncertainties affecting actual structural behaviour.The emphasis is on ships, with offshore structures teated primarily...

  16. Design Principles for Hybrid Ventilation

    DEFF Research Database (Denmark)

    Heiselberg, Per

    For many years mechanical and natural ventilation systems have developed separately. Naturally, the next step in this development is the development of ventilation concepts that utilize and combine the best features from each system to create a new type of ventilation system -Hybrid Ventilation....... The hybrid ventilation concepts, design challenges and - principles are discussed and illustrated by four building examples....

  17. Principles of modern digital design

    CERN Document Server

    Lala, Parag K

    2007-01-01

    A major objective of this book is to fill the gap between traditional logic design principles and logic design/optimization techniques used in practice. Over the last two decades several techniques for computer-aided design and optimization of logic circuits have been developed. However, underlying theories of these techniques are inadequately covered or not covered at all in undergraduate text books. This book covers not only the ""classical"" material found in current text books but also selected materials that modern logic designers need to be familiar with.

  18. Teaching Spreadsheets: Curriculum Design Principles

    CERN Document Server

    Tort, Francoise

    2010-01-01

    EuSpRIG concerns direct researchers to revisit spreadsheet education, taking into account error auditing tools, checklists, and good practices. This paper aims at elaborating principles to design a spreadsheet curriculum. It mainly focuses on two important issues. Firstly, it is necessary to establish the spreadsheet invariants to be taught, especially those concerning errors and good practices. Secondly, it is important to take into account the learners' ICT experience, and to encourage them to attitudes that foster self-learning. We suggest key principles for spreadsheet teaching, and we illustrate them with teaching guidelines.

  19. Industrial instrumentation principles and design

    CERN Document Server

    Padmanabhan, Tattamangalam R

    2000-01-01

    Pneumatic, hydraulic and allied instrumentation schemes have given way to electronic schemes in recent years thanks to the rapid strides in electronics and allied areas. Principles, design and applications of such state-of-the-art instrumentation schemes form the subject matter of this book. Through representative examples, the basic building blocks of instrumentation schemes are identified and each of these building blocks discussed in terms of its design and interface characteristics. The common generic schemes synthesized with such building blocks are dealt with subsequently. This forms the scope of Part I. The focus in Part II is on application. Displacement and allied instrumentation, force and allied instrumentation and process instrumentation in terms of temperature, flow, pressure level and other common process variables are dealt with separately and exhaustively. Despite the diversity in the sensor principles and characteristics and the variety in the applications and their environments, it is possib...

  20. Design principles underlying circadian clocks.

    OpenAIRE

    Rand, D.A.; Shulgin, B. V.; D. Salazar; Millar, A. J.

    2004-01-01

    A fundamental problem for regulatory networks is to understand the relation between form and function: to uncover the underlying design principles of the network. Circadian clocks present a particularly interesting instance, as recent work has shown that they have complex structures involving multiple interconnected feedback loops with both positive and negative feedback. While several authors have speculated on the reasons for this, a convincing explanation is still lacking.We analyse both t...

  1. Comprehensive Program Review: Applying TQM Principles.

    Science.gov (United States)

    Ostroth, D. David

    1996-01-01

    Reviews one system successfully used to implement Total Quality Management (TQM) principles and techniques in a student affairs department at a large public university. Discusses TQM applications and argues that implementation of TQM requires both planned staff training and an organization-wide culture change. (RJM)

  2. Applying Pedagogical Principles to CALL Courseware Development.

    Science.gov (United States)

    Wyatt, David H.

    This paper on the application of principles to computer-assisted language learning (CALL) first clarifies the the relationships between the capabilities of the computer (and computer-controlled technology) and the main approaches to second language learning. Fourteen common types of CALL programs are briefly reviewed. A "relational" classification…

  3. Design principles for precision mechanisms

    CERN Document Server

    Soemers, Herman

    2011-01-01

    The successful design of mechanisms for products, tools and equipment relies on excellent concepts and properly designed details. Both are covered in this book. Many of the examples presented have been realised in practice and properly evaluated, giving the reader/designer a high level of confidence. Every example comes with the considerations underlying the application and the limitations of the particular idea. This book is based on the work started in the 1960s by W. van der Hoek at Philips in Eindhoven, the Netherlands, and subsequently continued by M.P. Koster, culminating in the Dutch-language book “Constructieprincipes” [Design principles for accurate movement and positioning]. The core of their design approach has been preserved, while theory and examples were updated and the English language was adopted to reach a broad audience within the Netherlands as well as abroad. Herman (H.M.J.R.) Soemers is associated with the University of Twente, Enschede, the Netherlands. He also works as a technolog...

  4. Basic principles of applied nuclear techniques

    International Nuclear Information System (INIS)

    The technological applications of radioactive isotopes and radiation in South Africa have grown steadily since the first consignment of man-made radioisotopes reached this country in 1948. By the end of 1975 there were 412 authorised non-medical organisations (327 industries) using hundreds of sealed sources as well as their fair share of the thousands of radioisotope consignments, annually either imported or produced locally (mainly for medical purposes). Consequently, it is necessary for South African technologists to understand the principles of radioactivity in order to appreciate the industrial applications of nuclear techniques

  5. Macro-environmental policy: Principles and design

    International Nuclear Information System (INIS)

    The central theme of this book is how macro-environmental policy can be developed, which does not prescribe or suggest specific technologies and products bu realizes the environmental quality desired by changing the general context. The publication is composed of four main parts. The framework for analysis and the normative principles for policy design and evaluation, the first two parts, form the analytic core. The framework for analysis gives a classification of instruments in terms of permutations of a limited number of defining elements. The normative principles guide choices in instrument design and, as the flexible response strategy, guide their application in specific policies. Detailing two main new instruments (the standard method for life cycle analysis and the substance deposit, and applying the instrument strategy as developed to the cases make up the next two parts

  6. Redis applied design patterns

    CERN Document Server

    Chinnachamy, Arun

    2014-01-01

    This book is for developers who are already proficient in programming and capable of designing systems using traditional databases, but are new to Redis. It is assumed that you understand the basics of Redis and are familiar with the various data structures. You are also expected to be proficient in one or more programming languages through which you want to use Redis.

  7. Cryostat design case studies, principles and engineering

    CERN Document Server

    2016-01-01

    This book enables the reader to learn the fundamental and applied aspects of practical cryostat design by examining previous design choices and resulting cryostat performance. Through a series of extended case studies the book presents an overview of existing cryostat design covering a wide range of cryostat types and applications, including the magnet cryostats that comprise the majority of the Large Hadron Collider at CERN, space-borne cryostats containing sensors operating below 1 K, and large cryogenic liquid storage vessels. It starts with an introductory section on the principles of cryostat design including practical data and equations. This section is followed by a series of case studies on existing cryostats, describing the specific requirements of the cryostat, the challenges involved and the design choices made along with the resulting performance of the cryostat. The cryostat examples used in the studies are chosen to cover a broad range of cryostat applications and the authors of each case are ...

  8. Visual Design Principles: An Empirical Study of Design Lore

    Science.gov (United States)

    Kimball, Miles A.

    2013-01-01

    Many books, designers, and design educators talk about visual design principles such as balance, contrast, and alignment, but with little consistency. This study uses empirical methods to explore the lore surrounding design principles. The study took the form of two stages: a quantitative literature review to determine what design principles are…

  9. Design principles for riboswitch function.

    Directory of Open Access Journals (Sweden)

    Chase L Beisel

    2009-04-01

    Full Text Available Scientific and technological advances that enable the tuning of integrated regulatory components to match network and system requirements are critical to reliably control the function of biological systems. RNA provides a promising building block for the construction of tunable regulatory components based on its rich regulatory capacity and our current understanding of the sequence-function relationship. One prominent example of RNA-based regulatory components is riboswitches, genetic elements that mediate ligand control of gene expression through diverse regulatory mechanisms. While characterization of natural and synthetic riboswitches has revealed that riboswitch function can be modulated through sequence alteration, no quantitative frameworks exist to investigate or guide riboswitch tuning. Here, we combined mathematical modeling and experimental approaches to investigate the relationship between riboswitch function and performance. Model results demonstrated that the competition between reversible and irreversible rate constants dictates performance for different regulatory mechanisms. We also found that practical system restrictions, such as an upper limit on ligand concentration, can significantly alter the requirements for riboswitch performance, necessitating alternative tuning strategies. Previous experimental data for natural and synthetic riboswitches as well as experiments conducted in this work support model predictions. From our results, we developed a set of general design principles for synthetic riboswitches. Our results also provide a foundation from which to investigate how natural riboswitches are tuned to meet systems-level regulatory demands.

  10. Design Principles for Closed Loop Supply Chains

    NARCIS (Netherlands)

    H.R. Krikke (Harold); C.P. Pappis (Costas); G.T. Tsoulfas; J.M. Bloemhof-Ruwaard (Jacqueline)

    2001-01-01

    textabstractIn this paper we study design principles for closed loop supply chains. Closed loop supply chains aim at closing material flows thereby limiting emission and residual waste, but also providing customer service at low cost. We study 'traditional' and 'new' design principles known in the l

  11. An Analysis of the Economy Principle Applied in Cyber Language

    Institute of Scientific and Technical Information of China (English)

    肖钰敏

    2015-01-01

    With the development of network technology,cyber language,a new social dialect,is widely used in our life.The author analyzes how the economy principle is applied in cyber language from three aspects—word-formation,syntax and non-linguistic symbol.And the author collects,summarizes and analyzes the relevant language materials to prove the economy principle’s real existence in chat room and the reason why the economy principle is applied widely in cyber space.

  12. Applying the principles of augmented learning to photonics laboratory work

    Science.gov (United States)

    Fischer, U. H. P.; Haupt, Matthias; Reinboth, Christian; Just, Jens-Uwe

    2007-06-01

    Most modern communication systems are based on opto-electrical methods, wavelength division multiplex (WDM) being the most widespread. Likewise, the use of polymeric fibres (POF) as an optical transmission medium is expanding rapidly. Therefore, enabling students to understand how WDM and/or POF systems are designed and maintained is an important task of universities and vocational schools that offer education in photonics. In the current academic setting, theory is mostly being taught in the classroom, while students gain practical knowledge by performing lab experiments utilizing specialized teaching systems. In an ideal setting, students should perform such experiments with a high degree of autonomy. By applying the principles of augmented learning to photonics training, contemporary lab work can be brought closer to these ideal conditions. This paper introduces "OPTOTEACH", a new teaching system for photonics lab work, designed by Harz University and successfully released on the German market by HarzOptics. OPTOTEACH is the first POF-WDM teaching system, specifically designed to cover a multitude of lab experiments in the field of optical communication technology. It is illustrated, how this lab system is supplemented by a newly developed optical teaching software - "OPTOSOFT" - and how the combination of system and software creates a unique augmented learning environment. The paper details, how the didactic concept for the software was conceptualised and introduces the latest beta version. OPTOSOFT is specifically designed not only as an attachment to OPTOTEACH, it also allows students to rehearse various aspects of theoretical optics and experience a fully interactive and feature-rich self-learning environment. The paper further details the first experiences educators at Harz University have made working with the lab system as well as the teaching software. So far, the augmented learning concept was received mostly positive, although there is some potential

  13. Game Design Principles based on Human Error

    Directory of Open Access Journals (Sweden)

    Guilherme Zaffari

    2016-03-01

    Full Text Available This paper displays the result of the authors’ research regarding to the incorporation of Human Error, through design principles, to video game design. In a general way, designers must consider Human Error factors throughout video game interface development; however, when related to its core design, adaptations are in need, since challenge is an important factor for fun and under the perspective of Human Error, challenge can be considered as a flaw in the system. The research utilized Human Error classifications, data triangulation via predictive human error analysis, and the expanded flow theory to allow the design of a set of principles in order to match the design of playful challenges with the principles of Human Error. From the results, it was possible to conclude that the application of Human Error in game design has a positive effect on player experience, allowing it to interact only with errors associated with the intended aesthetics of the game.

  14. Paradigms and Principles Shaping Educational Design Research

    NARCIS (Netherlands)

    McKenney, Susan

    2014-01-01

    McKenney, S. (2013). Paradigms and Principles Shaping Educational Design Research. Invited panel presentation at the annual meeting of the European Association for Research on Learning and Instruction. August 27-31, Munich.

  15. Basic design principles of colorimetric vision systems

    Science.gov (United States)

    Mumzhiu, Alex M.

    1998-10-01

    Color measurement is an important part of overall production quality control in textile, coating, plastics, food, paper and other industries. The color measurement instruments such as colorimeters and spectrophotometers, used for production quality control have many limitations. In many applications they cannot be used for a variety of reasons and have to be replaced with human operators. Machine vision has great potential for color measurement. The components for color machine vision systems, such as broadcast quality 3-CCD cameras, fast and inexpensive PCI frame grabbers, and sophisticated image processing software packages are available. However the machine vision industry has only started to approach the color domain. The few color machine vision systems on the market, produced by the largest machine vision manufacturers have very limited capabilities. A lack of understanding that a vision based color measurement system could fail if it ignores the basic principles of colorimetry is the main reason for the slow progress of color vision systems. the purpose of this paper is to clarify how color measurement principles have to be applied to vision systems and how the electro-optical design features of colorimeters have to be modified in order to implement them for vision systems. The subject of this presentation far exceeds the limitations of a journal paper so only the most important aspects will be discussed. An overview of the major areas of applications for colorimetric vision system will be discussed. Finally, the reasons why some customers are happy with their vision systems and some are not will be analyzed.

  16. Principles for Effective Hypermedia Design.

    Science.gov (United States)

    Brooks, Randy M.

    1993-01-01

    Argues that effective hypermedia designs should meet four goals: (1) minimize clutter so that the document looks and feels simple to use; (2) create an image appropriate to the corporate sponsor and to the users' expectations; (3) provide ready access to stored information; (4) minimize the effort, technology, and resources needed. (SR)

  17. Team learning center design principles

    Energy Technology Data Exchange (ETDEWEB)

    Daily, B.; Loveland, J.; Whatley, A. [New Mexico State Univ., Las Cruces, NM (United States)] [and others

    1995-06-01

    This is a preliminary report of a multi-year collaboration of the authors addressing the subject: Can a facility be designed for team learning and would it improve the efficiency and effectiveness of team interactions? Team learning in this context is a broad definition that covers all activities where small to large groups of people come together to work, to learn, and to share through team activities. Multimedia, networking, such as World Wide Web and other tools, are greatly enhancing the capability of individual learning. This paper addresses the application of technology and design to facilitate group or team learning. Many organizational meetings need tens of people to come together to do work as a large group and then divide into smaller subgroups of five to ten to work and then to return and report and interact with the larger group. Current facilities were not, in general, designed for this type of meeting. Problems with current facilities are defined and a preliminary design solution to many of the identified problems is presented.

  18. Improving Business School Courses by Applying Lean Principles and Practices

    Science.gov (United States)

    Emiliani, M. L.

    2004-01-01

    Describes the application of lean principles and practices to the design and delivery of a graduate business course on leadership taken by part-time working professional students in a classroom setting. The principal objectives were to improve consistency between what was taught in the course and how the course was taught, eliminate waste, improve…

  19. Game Design Principles based on Human Error

    OpenAIRE

    Guilherme Zaffari; André Luiz Battaiola

    2016-01-01

    This paper displays the result of the authors’ research regarding to the incorporation of Human Error, through design principles, to video game design. In a general way, designers must consider Human Error factors throughout video game interface development; however, when related to its core design, adaptations are in need, since challenge is an important factor for fun and under the perspective of Human Error, challenge can be considered as a flaw in the system. The research u...

  20. Design Principles for Augmented Reality Learning

    Science.gov (United States)

    Dunleavy, Matt

    2014-01-01

    Augmented reality is an emerging technology that utilizes mobile, context-aware devices (e.g., smartphones, tablets) that enable participants to interact with digital information embedded within the physical environment. This overview of design principles focuses on specific strategies that instructional designers can use to develop AR learning…

  1. Design Communication: Transfer of Design Principles & Practice

    OpenAIRE

    Guille, Jackie

    2011-01-01

    The report documents a consultancy undertaken for Traidcraft, UK focused on one of their long-standing suppliers St. Mary's Mahila Shikshan Kendra (SMSK), Ahmedabad in the provision of training in design innovation, to both consolidate and sustain their existing creative practice in embroidered products and to support and facilitate the progressive development of design expertise at SMSK. Traidcraft is the UK’s leading Fairtrade organisation and has had a valued relationship with SMSK that st...

  2. Design Principles for Synthesizable Processor Cores

    DEFF Research Database (Denmark)

    Schleuniger, Pascal; McKee, Sally A.; Karlsson, Sven

    2012-01-01

    As FPGAs get more competitive, synthesizable processor cores become an attractive choice for embedded computing. Currently popular commercial processor cores do not fully exploit current FPGA architectures. In this paper, we propose general design principles to increase instruction throughput...... through the use of micro-benchmarks that our principles guide the design of a processor core that improves performance by an average of 38% over a similar Xilinx MicroBlaze configuration....... on FPGA-based processor cores: first, superpipelining enables higher-frequency system clocks, and second, predicated instructions circumvent costly pipeline stalls due to branches. To evaluate their effects, we develop Tinuso, a processor architecture optimized for FPGA implementation. We demonstrate...

  3. Design principles of interactive animated models for electronic learning tools

    OpenAIRE

    Дайняк, И. В.; Баев, В. С.; Карпович, С. Е.

    2013-01-01

    The design principles of interactive animated models for multimedia representation of educational materials were described. The interface of animated model was presented; it consists of header, border, scene, text message area, animation control panel, list of episodes. The animation effects for the applying to animated objects were developed, and templates of animated models were presented.

  4. Design Principles for Natural and Hybrid Ventilation

    DEFF Research Database (Denmark)

    Heiselberg, Per

    For many years mechanical and natural ventilation systems have developed separately. Naturally, the next step in this development is the development of ventilation concepts that utilize and combine the best features from each system to create a new type of ventilation system- Hybrid Ventilation....... The hybrid ventilation concepts, design challenges and principles are discussed and illustrated by four building examples....

  5. Teaching geometrical principles to design students

    Directory of Open Access Journals (Sweden)

    Christoph Bartneck

    2009-12-01

    Full Text Available We propose a new method of teaching the principles of geometry to design students. The students focus on a field of design in which geometry is the design: tessellation. We review different approaches to geometry and the field of tessellation before we discuss the setup of the course. Instead of employing 2D drawing tools, such as Adobe Illustrator, the students define their tessellation in mathematical formulas, using the Mathematica software. This procedure enables them to understand the mathematical principles on which graphical tools, such as Illustrator are built upon. But we do not stop at a digital representation of their tessellation design we continue to cut their tessellations in Perspex. It moves the abstract concepts of math into the real world, so that the students can experience them directly, which provides a tremendous reward to the students.

  6. A Protocol for Evaluating Contextual Design Principles

    Directory of Open Access Journals (Sweden)

    Arthur Stamps

    2014-11-01

    Full Text Available This paper explains how scientific data can be incorporated into urban design decisions, such as evaluating contextual design principles. The recommended protocols are based on the Cochrane Reviews that have been widely used in medical research. The major concepts of a Cochrane Review are explained, as well as the underlying mathematics. The underlying math is meta-analysis. Data are reported for three applications and seven contextual design policies. It is suggested that use of the Cochrane protocols will be of great assistance to planners by providing scientific data that can be used to evaluate the efficacies of contextual design policies prior to implementing those policies.

  7. Polymer composite principles applied to hair styling gels.

    Science.gov (United States)

    Wade Rafferty, Denise; Zellia, Joseph; Hasman, Daniel; Mullay, John

    2008-01-01

    A novel approach is taken to understand the mechanical performance of fixative-treated hair tresses. Polymer composite principles are applied to explain the performance. Examples are given for polyacrylate-2 crosspolymer that show that the choice of neutralizer affects the film properties of anionic acrylic polymers by plasticization or by hardening through ionic (physical) crosslinking. The effect of these changes in the polymer film on the composite properties was determined by mechanical stiffness and high-humidity curl retention testing. It is shown that both adhesion to the hair and polymer cohesion are important in determining fixative polymer performance. The implications of the results for the formulation of fixative systems are discussed.

  8. Intelligent computer systems in engineering design principles and applications

    CERN Document Server

    Sunnersjo, Staffan

    2016-01-01

    This introductory book discusses how to plan and build useful, reliable, maintainable and cost efficient computer systems for automated engineering design. The book takes a user perspective and seeks to bridge the gap between texts on principles of computer science and the user manuals for commercial design automation software. The approach taken is top-down, following the path from definition of the design task and clarification of the relevant design knowledge to the development of an operational system well adapted for its purpose. This introductory text for the practicing engineer working in industry covers most vital aspects of planning such a system. Experiences from applications of automated design systems in practice are reviewed based on a large number of real, industrial cases. The principles behind the most popular methods in design automation are presented with sufficient rigour to give the user confidence in applying them on real industrial problems. This book is also suited for a half semester c...

  9. Challenges in applying the ACPO principles in cloud forensic investigations

    Directory of Open Access Journals (Sweden)

    Harjinder Singh Lallie

    2012-03-01

    Full Text Available The numerous advantages offered by cloud computing has fuelled its growth and has made it one of the most significant of current computing trends. The same advantages have created complex issues for those conducting digital forensic investigations. Digital forensic investigators rely on the ACPO guidelines when conducting an investigation, however the guidelines make no reference to some of the issues presented by cloud investigations.This study investigates the impact of cloud computing on ACPO’s core principles and asks whether there is a need for the principles and guidelines to be reviewed to address the issues presented by cloud computing. Empirical research is conducted and data collected from key experts in the field of digital forensics.This research presents several key findings: there is a very real concern for how cloud computing will affect digital forensic investigations; the ACPO principles cannot easily be applied in all cloud investigations but are generally sufficient for cloud computing forensic investigations. However the advent of cloud computing is a significant development in technology and may in the near future warrant a review of the guidelines in particular to incorporate the involvement of third parties in cloud investigations.

  10. Principles and techniques for designing precision machines

    Energy Technology Data Exchange (ETDEWEB)

    Hale, L C

    1999-02-01

    This thesis is written to advance the reader's knowledge of precision-engineering principles and their application to designing machines that achieve both sufficient precision and minimum cost. It provides the concepts and tools necessary for the engineer to create new precision machine designs. Four case studies demonstrate the principles and showcase approaches and solutions to specific problems that generally have wider applications. These come from projects at the Lawrence Livermore National Laboratory in which the author participated: the Large Optics Diamond Turning Machine, Accuracy Enhancement of High- Productivity Machine Tools, the National Ignition Facility, and Extreme Ultraviolet Lithography. Although broad in scope, the topics go into sufficient depth to be useful to practicing precision engineers and often fulfill more academic ambitions. The thesis begins with a chapter that presents significant principles and fundamental knowledge from the Precision Engineering literature. Following this is a chapter that presents engineering design techniques that are general and not specific to precision machines. All subsequent chapters cover specific aspects of precision machine design. The first of these is Structural Design, guidelines and analysis techniques for achieving independently stiff machine structures. The next chapter addresses dynamic stiffness by presenting several techniques for Deterministic Damping, damping designs that can be analyzed and optimized with predictive results. Several chapters present a main thrust of the thesis, Exact-Constraint Design. A main contribution is a generalized modeling approach developed through the course of creating several unique designs. The final chapter is the primary case study of the thesis, the Conceptual Design of a Horizontal Machining Center.

  11. Universal Instructional Design Principles for Moodle

    Directory of Open Access Journals (Sweden)

    Tanya Elias

    2010-05-01

    Full Text Available The paper identifies a set of universal instructional design (UID principles appropriate to distance education (DE and tailored to the needs of instructional designers and instructors teaching online. These principles are then used to assess the accessibility level of a sample online course and the availability of options in its LMS platform (Moodle to increase course accessibility. Numerous accessibility-sensitive plug-in modules are found to be available to Moodle users, though relatively few features were included in the sample course analysed. This may be because they have not been made available to instructors at the institutional level. The paper offers a series of recommendations to improve the accessibility of online DE to learners with diverse abilities, disabilities, and needs.

  12. Implantable biomedical microsystems design principles and applications

    CERN Document Server

    Bhunia, Swarup; Sawan, Mohamad

    2015-01-01

    Research and innovation in areas such as circuits, microsystems, packaging, biocompatibility, miniaturization, power supplies, remote control, reliability, and lifespan are leading to a rapid increase in the range of devices and corresponding applications in the field of wearable and implantable biomedical microsystems, which are used for monitoring, diagnosing, and controlling the health conditions of the human body. This book provides comprehensive coverage of the fundamental design principles and validation for implantable microsystems, as well as several major application areas. Each co

  13. Generative design applied to industrial design

    OpenAIRE

    Rebelo Pinto, Carolina

    2015-01-01

    Few industrial and product designers are familiar with Generative Design and its possible benefits and limitations. This thesis is a work towards the understanding of what Generative Design with regards to Industrial Design and Product Design could be. The main quest of the thesis was to discover what are the main practices and current productions in the field of Generative Design in connection to Industrial and Product Design; and additionally what could be the possible opportunities for ind...

  14. Apply Design Patterns to Refactor Software Design

    Science.gov (United States)

    Baggs, Rhoda; Shaykhian, Gholam Ali

    2007-01-01

    Refactoring software design is a method of changing software design while explicitly preserving its unique design functionalities. Presented approach is to utilize design patterns as the basis for refactoring software design. Comparison of a design solution will be made through C++ programming language examples to exploit this approach. Developing reusable component will be discussed, the paper presents that the construction of such components can diminish the added burden of both refactoring and the use of design patterns.

  15. Do flow principles of operations management apply to computing centres?

    CERN Document Server

    Abaunza, Felipe; Hameri, Ari-Pekka; Niemi, Tapio

    2014-01-01

    By analysing large data-sets on jobs processed in major computing centres, we study how operations management principles apply to these modern day processing plants. We show that Little’s Law on long-term performance averages holds to computing centres, i.e. work-in-progress equals throughput rate multiplied by process lead time. Contrary to traditional manufacturing principles, the law of variation does not hold to computing centres, as the more variation in job lead times the better the throughput and utilisation of the system. We also show that as the utilisation of the system increases lead times and work-in-progress increase, which complies with traditional manufacturing. In comparison with current computing centre operations these results imply that better allocation of jobs could increase throughput and utilisation, while less computing resources are needed, thus increasing the overall efficiency of the centre. From a theoretical point of view, in a system with close to zero set-up times, as in the c...

  16. Y-12 Sustainable Design Principles for Building Design and Construction

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, J. G.

    2008-11-01

    B&W Y-12 is committed to modernizing the Y-12 complex to meet future needs with a sustainable and responsive infrastructure and to integrating sustainability principles and practices into Y-12 work (Y72-001, B&W Y-12 Environmental, Safety and Health Policy). This commitment to sustainability and specifically sustainable design of buildings is also incorporated into Presidential Executive Orders (EO), DOE Orders (DOE O), and goals. Sustainable building design is an approach to design, construct, and operate facilities in an efficient and environmentally sound manner that will produce a healthful, resource-efficient and productive working environment that is inherently protective of the environment. The DOE has established the following 5 Guiding Principles for High Performance Sustainable Building (HPSB), and has issued directives that require Y-12 to incorporate the principles and a number of supporting specific practices and techniques into building design, construction and renovation projects: (1) Employ Integrated Design Principles; (2) Optimize Energy Performance; (3) Protect and Conserve Water; (4) Enhance Indoor Environmental Quality; and (5) Reduce Environmental Impact of Materials. The purpose of this document is to present the required sustainable building principles, practices and techniques, summarize the key drivers for incorporating them into Y-12 projects, and present additional recommendations and resources that can be used to support sustainable buildings to enhance the environmental and economic performance of the Y-12 Complex.

  17. Design principles for therapeutic angiogenic materials

    Science.gov (United States)

    Briquez, Priscilla S.; Clegg, Lindsay E.; Martino, Mikaël M.; Gabhann, Feilim Mac; Hubbell, Jeffrey A.

    2016-01-01

    Despite extensive research, pro-angiogenic drugs have failed to translate clinically, and therapeutic angiogenesis, which has potential in the treatment of various cardiovascular diseases, remains a major challenge. Physiologically, angiogenesis — the process of blood-vessel growth from existing vasculature — is regulated by a complex interplay of biophysical and biochemical cues from the extracellular matrix (ECM), angiogenic factors and multiple cell types. The ECM can be regarded as the natural 3D material that regulates angiogenesis. Here, we leverage knowledge of ECM properties to derive design rules for engineering pro-angiogenic materials. We propose that pro-angiogenic materials should be biomimetic, incorporate angiogenic factors and mimic cooperative interactions between growth factors and the ECM. We highlight examples of material designs that demonstrate these principles and considerations for designing better angiogenic materials.

  18. Existential Design Applied in Universal Design Settings.

    Science.gov (United States)

    Torkildsby, Anne Britt

    2016-01-01

    The critical design method aims to discuss ways of opening up the (design) brief when planning, designing, building, operating and maintaining the future of the built environment - public as well as private, indoor as well as outdoor. Focusing on "designials" (fundamental forms of design being), the methodology intends to illustrate the fact that objects; including buildings, parks, transportation systems, etc. may directly encroach upon certain "existentials" (fundamental forms of human being) - thus shed light on how a design process is normally conducted, and furthermore, how that affects people's existential well-being. PMID:27534284

  19. Applied optics and optical design

    CERN Document Server

    Conrady, A E

    2011-01-01

    ""For the optical engineer it is an indispensable work."" - Journal, Optical Society of America""As a practical guide this book has no rival."" - Transactions, Optical Society""A noteworthy contribution,"" - Nature (London)Part I covers all ordinary ray-tracing methods, together with the complete theory of primary aberrations and as much of higher aberration as is needed for the design of telescopes, low-power microscopes and simple optical systems. Chapters: Fundamental Equations, Spherical Aberration, Physical Aspect of Optical Images, Chromatic Aberration, Design of Achromatic Object-Glass

  20. Applying persuasive design in a diabetes mellitus application

    OpenAIRE

    Smink, Sjoerd

    2012-01-01

    This paper describes persuasive design methods and compares this to an application currently under development for diabetes mellitus patients. Various elements of persuasion and a categorization of persuasion types are mentioned. Also discussed are principles of how successful persuasion should be designed, as well as the practical applications and ethics of persuasive design. This paper is not striving for completeness of theories on the topic, but uses the theories to compare it to an appli...

  1. Applying Software Design Methodology to Instructional Design

    Science.gov (United States)

    East, J. Philip

    2004-01-01

    The premise of this paper is that computer science has much to offer the endeavor of instructional improvement. Software design processes employed in computer science for developing software can be used for planning instruction and should improve instruction in much the same manner that design processes appear to have improved software. Techniques…

  2. Applying Craniofacial Principles to Neurosurgical Exposures in Cerebrovascular Aneurysm Repair.

    Science.gov (United States)

    Alperovich, Michael; Frey, Jordan D; Potts, Matthew B; Riina, Howard A; Staffenberg, David A

    2016-06-01

    The subspecialty of craniofacial surgery emphasizes skeletal exposure, preservation of critical structures, and provision of a superior cosmetic result. In recent decades, an emphasis on minimally invasive neurosurgical exposure has paved the way for increased collaboration between neurosurgeons and craniofacial surgeons.The 1990s saw the growing popularity of an eyebrow incision for orbital roof craniotomies in neurosurgery to address lesions in the anterior skull base. Disadvantages of this approach included conspicuous scarring above the brow skin, risk of injury to the frontal branch of the facial nerve, and numbness from supraorbital or supratrochlear nerve transection.A transpalpebral approach was first described in 2008 in the neurosurgical literature. An approach familiar to the craniofacial surgeon, transpalpebral exposure is used for zygomaticomaxillary complex fractures as well as aesthetic brow and periorbital surgery.In conjunction with neurosurgery, the authors have applied craniofacial principles to address the major pitfalls of the transpalpebral craniotomy. The authors present their patient series experience. Hopefully, in the future, other institutions will have increased collaboration between craniofacial surgeons and neurosurgeons. PMID:27192638

  3. Principles of Language Learning Activity Design Based on Constructivism

    Institute of Scientific and Technical Information of China (English)

    于玉星

    2010-01-01

    <正>This essay introduces constructivism and its four key theories in learning and explores its applications in language learning activity design.Following the theoretical background analysis,it proposes three principles concerning English language teaching activity design,namely interactive thinking principle,I + 1 principle and authentic communication principle.This paper also provides some practical teaching activities such as supporting examples of how these three principles can work in language teaching.

  4. The Extent of Jordanian Banks Commitment in Applying the Principles of Corporate Governance

    OpenAIRE

    Eman Al hanini

    2014-01-01

    This study aimed to reveal the extent of Jordanian banks? commitment to apply the principles of corporate governance. And to achieve this objective , a questionnaire was designed and distributed to a sample consisted of 120 respondents of the general managers? assistants, managers of the administrations , managers of the branches, the assistants of the managers of the branches and the employees of the audit departments in the Jordanian banks. After data was analyzed using SPSS, the study conc...

  5. Design Principles for Nickel/Hydrogen Cells and Batteries

    Science.gov (United States)

    Thaller, Lawrence H.; Manzo, Michelle A.; Gonzalez-Sanabria, Olga D.

    1987-01-01

    Individual-pressure-vessel (IPV) nickel/hydrogen cells and bipolar batteries developed for use as energy-storage subsystems for satelite applications. Design principles applied draw upon extensive background in separator technology, alkaline-fuel-cell technology and several alkaline-cell technology areas. Principals are rather straightforward applications of capillary-force formalisms, coupled with slowly developing data base resulting from careful post-test analyses. Based on preconceived assumptions relative to how devices work and how to be designed so they display longer cycle lives at deep discharge.

  6. Design principles of shift current photovoltaics

    Science.gov (United States)

    Cook, Ashley; Fregoso, Benjamin; de Juan, Fernando; Moore, Joel

    While the basic principles and limitations of conventional solar cells are well understood, relatively little attention has gone toward evaluating and maximizing the potential efficiency of photovoltaic devices based on shift currents. In this work, a sum rule approach is introduced and used to outline design principles for optimizing shift currents for photon energies near the band gap, which depend on wavefunctions via Berry connections as well as standard band structure. Using these we identify two new classes of shift current photovoltaics, ferroelectric polymer films and orthorhombic monochalcogenides, both of which exhibit peak photoresponsivities larger than predictions for previously-known photovoltaics of this type. Using physically-motivated tight-binding models, the full frequency dependent response of these materials is obtained. Exploring the phase space of these models, we find photoresponsivities that can exceed 100 mA/W. These results show that considering the microscopic origin of shift current via effective models allows one to improve the possible efficiency of devices using this mechanism and better grasp their potential to compete with conventional solar cells. This work was completed with the support of an NSERC Michael Smith Foreign Study Supplement.

  7. Applying the Legal Security Principle in Administrative Law

    Directory of Open Access Journals (Sweden)

    Vasilica NEGRUŢ

    2015-08-01

    Full Text Available The objective of the paper is founded on a very current topic and of real interest. Using content analysis, through a descriptive study research, this study aims at identifying the content of the legal security principle and the way in which the courts in Romania, the public authorities achieve a proper application of this European principle. For this purpose, it was achieved an analysis of specific objectives aiming at, in particular, the requirements of legal security principle and the way in which they manifest in the national law. We appreciate that, although it does not beneficiate of an express assignment in the Romanian legislation, being a creation of jurisprudence, the legal security principle is in the current context, a fundamental principle of state law, which should give every citizen the opportunity to evolve into a secured, predictable legal environment.

  8. 12 CFR 223.22 - What valuation and timing principles apply to asset purchases?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false What valuation and timing principles apply to...) Valuation and Timing Principles Under Section 23A § 223.22 What valuation and timing principles apply to asset purchases? (a) Valuation—(1) In general. Except as provided in paragraph (a)(2) of this section,...

  9. 12 CFR 223.21 - What valuation and timing principles apply to credit transactions?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false What valuation and timing principles apply to...) Valuation and Timing Principles Under Section 23A § 223.21 What valuation and timing principles apply to credit transactions? (a) Valuation—(1) Initial valuation. Except as provided in paragraph (a)(2) or...

  10. Fuel cells principles, design, and analysis

    CERN Document Server

    Revankar, Shripad T

    2014-01-01

    ""This book covers all essential themes of fuel cells ranging from fundamentals to applications. It includes key advanced topics important for understanding correctly the underlying multi-science phenomena of fuel cell processes. The book does not only cope with traditional fuel cells but also discusses the future concepts of fuel cells. The book is rich on examples and solutions important for applying the theory into practical use.""-Peter Lund, Aalto University, Helsinki""A good introduction to the range of disciplines needed to design, build and test fuel cells.""-Nigel Brandon, Imperial Co

  11. [The bioethical principlism model applied in pain management].

    Science.gov (United States)

    Souza, Layz Alves Ferreira; Pessoa, Ana Paula da Costa; Barbosa, Maria Alves; Pereira, Lilian Varanda

    2013-03-01

    An integrative literature review was developed with the purpose to analyze the scientific production regarding the relationships between pain and the principles of bioethics (autonomy, beneficence, nonmaleficence and justice). Controlled descriptors were used in three international data sources (LILACS, SciELO, MEDLINE), in April of 2012, totaling 14 publications categorized by pain and autonomy, pain and beneficence, pain and nonmaleficence, pain and justice. The adequate relief of pain is a human right and a moral issue directly related with the bioethical principlism standard model (beneficence, non-maleficence, autonomy and justice). However, many professionals overlook the pain of their patients, ignoring their ethical role when facing suffering. It was concluded that principlism has been neglected in the care of patients in pain, showing the need for new practices to change this setting.

  12. Principles of human joint replacement design and clinical application

    CERN Document Server

    Buechel, Frederick F

    2015-01-01

    This book is written for the users and designers of joint replacements. In its second extended edition it conveys to the reader the knowledge accumulated by the authors during their forty year effort on the development of replacement devices for the lower limb for the purpose of aiding the reader in their design and evaluation of joint replacement devices. The early chapters describe the engineering, scientific and medical principles needed for replacement joint evaluation. One must understand the nature and performance of the materials involved and their characteristics in vivo, i.e. the response of the body to implant materials. It is also essential to understand the response of the implants to applied loading and motion, particularly in the hostile physiological environment. A chapter describes the design methodology now required for joint replacement in the USA and EU countries. The remaining chapters provide a history of joint replacement, an evaluation of earlier and current devices and sample case hist...

  13. Principles of Human Joint Replacement Design and Clinical Application

    CERN Document Server

    Buechel, Frederick F

    2012-01-01

    Drs. Buechel, an orthopaedic surgeon, and Pappas, a professor of Mechanical Engineering, are the designers of several successful joint replacement systems. The most well-known of these is the pioneering LCS knee replacement. They have written this book for the users and designers of joint replacements. It is an attempt to convey to the reader the knowledge accumulated by the authors during their thirty five year effort on the development of replacement devices for the lower limb for the purpose of aiding the reader in their design and evaluation of joint replacement devices. The early chapters describe the engineering, scientific and medical principles needed for replacement joint evaluation. One must understand the nature and performance of the materials involved and their characteristics in vivo, i.e. the response of the body to implant materials. It is also essential to understand the response of the implants to applied loading and motion, particularly in the hostile physiological environment. A chapter de...

  14. Toward instructional design principles: Inducing Faraday's law with contrasting cases

    Science.gov (United States)

    Kuo, Eric; Wieman, Carl E.

    2016-06-01

    Although physics education research (PER) has improved instructional practices, there are not agreed upon principles for designing effective instructional materials. Here, we illustrate how close comparison of instructional materials could support the development of such principles. Specifically, in discussion sections of a large, introductory physics course, a pair of studies compare two instructional strategies for teaching a physics concept: having students (i) explain a set of contrasting cases or (ii) apply and build on previously learned concepts. We compare these strategies for the teaching of Faraday's law, showing that explaining a set of related contrasting cases not only improves student performance on Faraday's law questions over building on a previously learned concept (i.e., Lorentz force), but also prepares students to better learn subsequent topics, such as Lenz's law. These differences persist to the final exam. We argue that early exposure to contrasting cases better focuses student attention on a key feature related to both concepts: change in magnetic flux. Importantly, the benefits of contrasting cases for both learning and enjoyment are enhanced for students who did not first attend a Faraday's law lecture, consistent with previous research suggesting that being told a solution can circumvent the benefits of its discovery. These studies illustrate an experimental approach for understanding how the structure of activities affects learning and performance outcomes, a first step toward design principles for effective instructional materials.

  15. Lean principles applied to software development – avoiding waste

    Directory of Open Access Journals (Sweden)

    Ionel NAFTANAILA

    2009-12-01

    Full Text Available Under the current economic conditions many organizations strive to continue the trend towards adopting better software development processes, in order to take advantage of the numerous benefits that these can offer. Those benefits include quicker return on investment, better software quality, and higher customer satisfaction. To date, however, there is little body of research that can guide organizations in adopting modern software development practices, especially when it comes to Lean thinking and principles. To address this situation, the current paper identifies and structures the main wastes (or muda in Lean terms in software development as described by Lean principles, in an attempt to bring into researchers’ and practitioners’ attention Lean Software Development, a modern development methodology based on well-established practices such as Lean Manufacturing or Toyota Production System.

  16. An Approach to Representation for Principle Scheme Design

    Institute of Scientific and Technical Information of China (English)

    ZhangJianming; WeiXiaoPeng; 等

    2002-01-01

    One of the open issues in principle scheme design of mechanical systems is principle representation,which not only outlies the physical principles,but also facilitates the design synthesis.An energy-based approach to represent principle scheme design is proposed.Firstly,an energy interaction model of mechanical systems is established and an intermediate model is derived,in which principle scheme design is transformed into solving the energy functions of system.Then the energy functions are modeled with the language of bond graphs,and principle representation for componenyts is presented.Finally,characteristics of the developed representation approach are analyzed and a design example of gate drive system is given to demonstrate this approach.

  17. 41 CFR 102-3.95 - What principles apply to the management of advisory committees?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What principles apply to...-FEDERAL ADVISORY COMMITTEE MANAGEMENT How Are Advisory Committees Managed? § 102-3.95 What principles... principles to the management of their advisory committees: (a) Provide adequate support. Before...

  18. The Cheshire Cat principle applied to hybrid bag models

    International Nuclear Information System (INIS)

    Here is argued for the Cheshire Cat point of view according to which the bag (itself) has only notational, but no physical significance. It is explained in a 1+1 dimensional exact Cheshire Cat model how a fermion can escape from the bag by means of an anomaly. We also suggest that suitably constructed hybrid bag models may be used to fix such parameters of effective Lagrangians that can otherwise be obtained from experiments only. This idea is illustrated in a calculation of the mass of the pseudoscalar η' meson in 1+1 dimension. Thus there is hope to find a construction principle for a phenomenologically sensible model. (orig.)

  19. Principles of Micellar Electrokinetic Capillary Chromatography Applied in Pharmaceutical Analysis

    Directory of Open Access Journals (Sweden)

    Árpád Gyéresi

    2013-02-01

    Full Text Available Since its introduction capillary electrophoresis has shown great potential in areas where electrophoretic techniques have rarely been used before, including here the analysis of pharmaceutical substances. The large majority of pharmaceutical substances are neutral from electrophoretic point of view, consequently separations by the classic capillary zone electrophoresis; where separation is based on the differences between the own electrophoretic mobilities of the analytes; are hard to achieve. Micellar electrokinetic capillary chromatography, a hybrid method that combines chromatographic and electrophoretic separation principles, extends the applicability of capillary electrophoretic methods to neutral analytes. In micellar electrokinetic capillary chromatography, surfactants are added to the buffer solution in concentration above their critical micellar concentrations, consequently micelles are formed; micelles that undergo electrophoretic migration like any other charged particle. The separation is based on the differential partitioning of an analyte between the two-phase system: the mobile aqueous phase and micellar pseudostationary phase. The present paper aims to summarize the basic aspects regarding separation principles and practical applications of micellar electrokinetic capillary chromatography, with particular attention to those relevant in pharmaceutical analysis.

  20. General design safety principles for nuclear power plants

    International Nuclear Information System (INIS)

    This Safety Guide provides the safety principles and the approach that have been used to implement the Code in the Safety Guides. These safety principles and the approach are tied closely to the safety analyses needed to assist the design process, and are used to verify the adequacy of nuclear power plant designs. This Guide also provides a framework for the use of other design Safety Guides. However, although it explains the principles on which the other Safety Guides are based, the requirements for specific applications of these principles are mostly found in the other Guides

  1. Human Systems Interface Design Methods Using Ecological Interface Design Principles

    International Nuclear Information System (INIS)

    The results of this study categorized into two parts. The first part is the guidelines for EID designs. The procedure to observe for EID design is composed of 6 steps; 1) to define a target system, 2) to make an abstraction hierarchy model, 3) to check the link structure among each components included in the layers of abstraction hierarchy model, 4) to transform information requirements to variables, 5) to make the graphs related to each variables, 6) to check the graphs by visual display design principles and heuristic rules. The second part is an EID design alternative for nuclear power plant. The EID for high level function represents the energy balance and energy flow in each loop of nuclear power plant. The EID for middle level function represents the performance indicators of each equipment involved in the all processes of changing from coolants to steam. The EID for low level function represents the values measured in each equipment such as temperature, pressure, water level and so on

  2. Applying principles of intercultural communication to personality disorder therapy.

    Science.gov (United States)

    Leising, Daniel

    2008-09-01

    Psychotherapy with patients who were diagnosed with a personality disorder bears a strong resemblance to intercultural communication. I suggest conceptualizing the situation of a patient with a personality disorder as being similar to that of an overseas traveller. Like the traveller, the patient faces the task of getting along in a social environment that does not share many of his or her ingrained values regarding 'appropriate' interpersonal behaviour. In order to reduce the potential for misunderstandings and interpersonal problems, the patient would benefit from (a) learning about the culturally accepted rules of interacting and (b) partly adopting those rules. Borrowing from training manuals for intercultural communication, I suggest a number of therapeutic principles that specifically address the discrepancies between the patient's habits and internalized values, and the cultural conventions that govern the social environment in which the patient lives. PMID:18426694

  3. Applying the Principles of Homicide by Heart Attack.

    Science.gov (United States)

    Hlavaty, Leigh; Sung, LokMan

    2016-06-01

    Homicide by heart attack is a well-established model in forensic pathology that describes death elicited during or immediately after a criminal act where a threat or fear of physical injury is present. After its introduction nearly 4 decades ago, the principle has undergone a handful of modifications but still maintains its core concepts. All cases of this nature during a 20-year period at the Wayne County Medical Examiner's Office were compared and contrasted for demographics, circumstances and scene investigation, and autopsy and toxicology findings. Of the cases fulfilling the previously established criteria for homicide by heart attack, more than 80% displayed significant changes because of hypertension. This finding coincides with the high prevalence of hypertension in our urban population and highlights the significance of this disease. Also present were minor external and internal injuries in select cases, which reinforce the understanding that physical contact between the decedent and assailant does not preclude this diagnosis. PMID:27049661

  4. Applying the Principles of Homicide by Heart Attack.

    Science.gov (United States)

    Hlavaty, Leigh; Sung, LokMan

    2016-06-01

    Homicide by heart attack is a well-established model in forensic pathology that describes death elicited during or immediately after a criminal act where a threat or fear of physical injury is present. After its introduction nearly 4 decades ago, the principle has undergone a handful of modifications but still maintains its core concepts. All cases of this nature during a 20-year period at the Wayne County Medical Examiner's Office were compared and contrasted for demographics, circumstances and scene investigation, and autopsy and toxicology findings. Of the cases fulfilling the previously established criteria for homicide by heart attack, more than 80% displayed significant changes because of hypertension. This finding coincides with the high prevalence of hypertension in our urban population and highlights the significance of this disease. Also present were minor external and internal injuries in select cases, which reinforce the understanding that physical contact between the decedent and assailant does not preclude this diagnosis.

  5. Applying Operant Conditioning Principles to the Management of Organizations.

    Science.gov (United States)

    DeVries, David L.; Jablonsky, Stephen F.

    Following Walter Nord (1969), the present article contains a predictive model of individual behavior based on both operant conditioning and management literatures. The behavior of an organizational member is seen as a function of the reinforcement contingencies applied by various groups in his environment and of his cognitive assessment of such…

  6. Design Principles for Improving the Process of Publishing Open data

    OpenAIRE

    Zuiderwijk, A.M.G.; Janssen, M.F.W.H.A.; Choenni, R.; Meijer, R.F.

    2014-01-01

    · Purpose: Governments create large amounts of data. However, the publication of open data is often cumbersome and there are no standard procedures and processes for opening data. This blocks the easy publication of government data. The purpose of this paper is to derive design principles for improving the open data publishing process of public organizations. · Design/methodology/approach: Action Design Research (ADR) was employed to derive design principles. The literature was used as a foun...

  7. Teaching the Principles of Effective Online Course Design: What Works?

    Directory of Open Access Journals (Sweden)

    Clare Gormley

    2014-06-01

    Full Text Available While much has been written about the pedagogy and challenges of online learning, there is comparatively little research that advises how online course design competencies can be achieved. Certainly a growing range of course design resources is being created and made openly available, but there is a need to evaluate their actual impact on practice. This predominantly qualitative study describes the impact of two learning interventions – open online tutorials and a design and development workshop – aimed at introducing the fundamentals of online course design. Four online course developers at an Irish university were interviewed about their experiences creating multimedia-based online courses. Two of the developers were given access to targeted learning interventions and were subsequently interviewed about their experiences using those interventions. The main findings were that novice online course developers can potentially learn and apply design principles through a dedicated introductory phase, techniques that promote discussion of effective pedagogy, and ongoing collaboration in course design. These strategies could be adapted to specific contexts elsewhere.

  8. Applying the Principles of Augmented Learning to Photonics Laboratory Work

    CERN Document Server

    Fischer, Ulrich H P; Just, Jens-Uwe; Haupt, Matthias

    2007-01-01

    This paper introduces "OPTOTEACH", a new teaching system for photonics lab work, designed by Harz University and successfully released on the German market by HarzOptics. OPTOTEACH is the first POF-WDM teaching system, specifically designed to cover a multitude of lab experiments in the field of optical communication technology. It is illustrated, how this lab system is supplemented by a newly developed optical teaching software - "OPTOSOFT" - and how the combination of system and software creates a unique augmented learning environment. The paper details, how the didactic concept for the software was conceptualised and introduces the latest beta version. OPTOSOFT is specifically designed not only as an attachment to OPTOTEACH, it also allows students to rehearse various aspects of theoretical optics and experience a fully interactive and feature-rich self-learning environment. The paper further details the first experiences educators at Harz University have made working with the lab system as well as the tea...

  9. Fractographic principles applied to Y-TZP mechanical behavior analysis.

    Science.gov (United States)

    Ramos, Carla Müller; Cesar, Paulo Francisco; Bonfante, Estevam Augusto; Rubo, José Henrique; Wang, Linda; Borges, Ana Flávia Sanches

    2016-04-01

    The purpose of this study was to evaluate the use of fractography principles to determine the fracture toughness of Y-TZP dental ceramic in which KIc was measured fractographically using controlled-flaw beam bending techniques and to correlate the flaw distribution with the mechanical properties. The Y-TZP blocks studied were: Zirconia Zirklein (ZZ); Zirconcad (ZCA); IPS e.max ZirCad (ZMAX); and In Ceram YZ (ZYZ). Samples were prepared (16mm×4mm×2mm) according to ISO 6872 specifications and subjected to three-point bending at a crosshead speed of 0.5mm/min. Weibull probability curves (95% confidence bounds) were calculated and a contour plot with the Weibull modulus (m) versus characteristic strength (σ0) was used to examine the differences among groups. The fractured surface of each specimen was inspected in a scanning electron microscope (SEM) for qualitative and quantitative fractographic analysis. The critical defect size (c) and fracture toughness (KIc) were estimated. The fractured surfaces of the samples from all groups showed similar fractographic characteristics, except ZCA showed pores and defects. Fracture toughness and the flexural strength values were not different among the groups except for ZCA. The characteristic strength (pzirconia polycrystalline ceramics. PMID:26722988

  10. Welding As Science: Applying Basic Engineering Principles to the Discipline

    Science.gov (United States)

    Nunes, A. C., Jr.

    2010-01-01

    This Technical Memorandum provides sample problems illustrating ways in which basic engineering science has been applied to the discipline of welding. Perhaps inferences may be drawn regarding optimal approaches to particular welding problems, as well as for the optimal education for welding engineers. Perhaps also some readers may be attracted to the science(s) of welding and may make worthwhile contributions to the discipline.

  11. Universal Design: Process, Principles, and Applications

    Science.gov (United States)

    Burgstahler, Sheryl

    2009-01-01

    Designing any product or environment involves the consideration of many factors, including aesthetics, engineering options, environmental issues, safety concerns, industry standards, and cost. Typically, designers focus their attention on the average user. In contrast, universal design (UD), according to the Center for Universal Design," is the…

  12. Application of Lean Principles to Design Processes in Construction Consultancy Firms

    Directory of Open Access Journals (Sweden)

    Marzouk, Mohamed

    2011-12-01

    Full Text Available Simulation modelling and Lean principles have both been applied in the construction industry to improve work processes. The outcomes from their implementation are outstanding and have motivated construction researchers to seek means by which other aspects of construction production could benefit from this development. Therefore the aim of this research is to use computer simulation as a tool for assessing the impact of applying Lean principles to design processes in construction consultancy firms to aid in decision making at early stages of construction projects. A comprehensive model for the design process was built before the principles of Lean construction were depicted in the model. Through a detailed case study, it was concluded that applying Lean construction principles to the design process significantly helped to improve process efficiency, in terms of reduced process durations and increased resource utilisation.

  13. Human factor engineering applied to nuclear power plant design

    Energy Technology Data Exchange (ETDEWEB)

    Manrique, A. [TECNATOM SA, BWR General Electric Business Manager, Madrid (Spain); Valdivia, J.C. [TECNATOM SA, Operation Engineering Project Manager, Madrid (Spain); Jimenez, A. [TECNATOM SA, Operation Engineering Div. Manager, Madrid (Spain)

    2001-07-01

    For the design and construction of new nuclear power plants as well as for maintenance and operation of the existing ones new man-machine interface designs and modifications are been produced. For these new designs Human Factor Engineering must be applied the same as for any other traditional engineering discipline. Advantages of implementing adequate Human Factor Engineering techniques in the design of nuclear reactors have become not only a fact recognized by the majority of engineers and operators but also an explicit requirement regulated and mandatory for the new designs of the so called advanced reactors. Additionally, the big saving achieved by a nuclear power plant having an operating methodology which significantly decreases the risk of operating errors makes it necessary and almost vital its implementation. The first step for this is preparing a plan to incorporate all the Human Factor Engineering principles and developing an integral design of the Instrumentation and Control and Man-machine interface systems. (author)

  14. Urban Principles for Ecological Landscape Design and Maintenance: Scientific Fundamentals

    Directory of Open Access Journals (Sweden)

    Steward T. A. Pickett

    2008-01-01

    Full Text Available Urban ecology is a rapidly developing scientific discipline with great relevance to sustainable city design and management. Though several frameworks have been proposed in the last 10 years, urban ecology, as yet, has no complete, mature theory. There are, however, general principles emerging that may facilitate the development of such a theory. In the meantime, these principles can serve as useful guides for ecological landscape design and maintenance. This paper aims to use the principles to conceptually frame a series of papers to follow in this special issue. The main ecological principles concerning cities are that: 1 Cities are ecosystems; 2 Cities are spatially heterogeneous; 3 Cities are dynamic; 4 Human and natural processes interact in cities; and 5 Ecological processes are still at work and are important in cities. The first three principles address the structure of cities and the change in structure through time. The remaining two principles focus on ecological processes in cities. We briefly summarize each of these principles and their roots in the ecological and design fields. Each principle points to ecological functions that can be translated into ecosystem services. Application of these principles to ecological landscape design and maintenance is discussed.

  15. Educational software design: applying models of learning

    OpenAIRE

    Richards, Stephen

    2011-01-01

    The model of learning adopted within this paper is the 'spreading ripples' (SR) model proposed by Race (1994). This model was chosen for two important reasons. First, it makes use of accessible ideas and language, .and is therefore simple. Second, .Race suggests that the model can be used in the design, of educational and training programmes (and can thereby be applied to the design of computer-based learning materials).DOI:10.1080/0968776960040303

  16. Applied game theory and optimal mechanism design

    OpenAIRE

    Zhang, Qi

    2014-01-01

    This thesis applies game theory to study optimal toehold bidding strategies during takeover competition, the problem of optimal design of voting rules and the design of package bidding mechanism to implement the core allocations. It documents three different research questions that are all related to auction theory. Chapter 2 develops a two-stage takeover game to explain toehold puzzle in the context of takeover. Potential bidders are allowed to acquire target shares in the open market, subje...

  17. Architectural design of heterogeneous metallic nanocrystals--principles and processes.

    Science.gov (United States)

    Yu, Yue; Zhang, Qingbo; Yao, Qiaofeng; Xie, Jianping; Lee, Jim Yang

    2014-12-16

    CONSPECTUS: Heterogeneous metal nanocrystals (HMNCs) are a natural extension of simple metal nanocrystals (NCs), but as a research topic, they have been much less explored until recently. HMNCs are formed by integrating metal NCs of different compositions into a common entity, similar to the way atoms are bonded to form molecules. HMNCs can be built to exhibit an unprecedented architectural diversity and complexity by programming the arrangement of the NC building blocks ("unit NCs"). The architectural engineering of HMNCs involves the design and fabrication of the architecture-determining elements (ADEs), i.e., unit NCs with precise control of shape and size, and their relative positions in the design. Similar to molecular engineering, where structural diversity is used to create more property variations for application explorations, the architectural engineering of HMNCs can similarly increase the utility of metal NCs by offering a suite of properties to support multifunctionality in applications. The architectural engineering of HMNCs calls for processes and operations that can execute the design. Some enabling technologies already exist in the form of classical micro- and macroscale fabrication techniques, such as masking and etching. These processes, when used singly or in combination, are fully capable of fabricating nanoscopic objects. What is needed is a detailed understanding of the engineering control of ADEs and the translation of these principles into actual processes. For simplicity of execution, these processes should be integrated into a common reaction system and yet retain independence of control. The key to architectural diversity is therefore the independent controllability of each ADE in the design blueprint. The right chemical tools must be applied under the right circumstances in order to achieve the desired outcome. In this Account, after a short illustration of the infinite possibility of combining different ADEs to create HMNC design

  18. Architectural design of heterogeneous metallic nanocrystals--principles and processes.

    Science.gov (United States)

    Yu, Yue; Zhang, Qingbo; Yao, Qiaofeng; Xie, Jianping; Lee, Jim Yang

    2014-12-16

    CONSPECTUS: Heterogeneous metal nanocrystals (HMNCs) are a natural extension of simple metal nanocrystals (NCs), but as a research topic, they have been much less explored until recently. HMNCs are formed by integrating metal NCs of different compositions into a common entity, similar to the way atoms are bonded to form molecules. HMNCs can be built to exhibit an unprecedented architectural diversity and complexity by programming the arrangement of the NC building blocks ("unit NCs"). The architectural engineering of HMNCs involves the design and fabrication of the architecture-determining elements (ADEs), i.e., unit NCs with precise control of shape and size, and their relative positions in the design. Similar to molecular engineering, where structural diversity is used to create more property variations for application explorations, the architectural engineering of HMNCs can similarly increase the utility of metal NCs by offering a suite of properties to support multifunctionality in applications. The architectural engineering of HMNCs calls for processes and operations that can execute the design. Some enabling technologies already exist in the form of classical micro- and macroscale fabrication techniques, such as masking and etching. These processes, when used singly or in combination, are fully capable of fabricating nanoscopic objects. What is needed is a detailed understanding of the engineering control of ADEs and the translation of these principles into actual processes. For simplicity of execution, these processes should be integrated into a common reaction system and yet retain independence of control. The key to architectural diversity is therefore the independent controllability of each ADE in the design blueprint. The right chemical tools must be applied under the right circumstances in order to achieve the desired outcome. In this Account, after a short illustration of the infinite possibility of combining different ADEs to create HMNC design

  19. Applying principles of health system strengthening to eye care

    Directory of Open Access Journals (Sweden)

    Karl Blanchet

    2012-01-01

    Full Text Available Understanding Health systems have now become the priority focus of researchers and policy makers, who have progressively moved away from a project-centred perspectives. The new tendency is to facilitate a convergence between health system developers and disease-specific programme managers in terms of both thinking and action, and to reconcile both approaches: one focusing on integrated health systems and improving the health status of the population and the other aiming at improving access to health care. Eye care interventions particularly in developing countries have generally been vertically implemented (e.g. trachoma, cataract surgeries often with parallel organizational structures or specialised disease specific services. With the emergence of health system strengthening in health strategies and in the service delivery of interventions there is a need to clarify and examine inputs in terms governance, financing and management. This present paper aims to clarify key concepts in health system strengthening and describe the various components of the framework as applied in eye care interventions.

  20. Applying Evidence-based Medicine Principles to Fracture Management

    Directory of Open Access Journals (Sweden)

    Joseph eBernstein

    2014-10-01

    Full Text Available Bone has the capacity to regenerate and not scar after injury—-sometimes leaving behind no evidence at all of a prior fracture. As surgeons capable of facilitating such healing, it becomes our responsibility to help choose a treatment that minimizes functional deficits and residual symptoms. And in the case of the geriatric hip fracture, we have seen the accumulation of a vast amount of evidence to help guide us.The best method we currently have for selecting treatment plans is by the practice of evidence-based medicine. According to the now accepted hierarchy, the best is called Level I evidence (eg, well performed randomized controlled trials—but this evidence is best only if it is available and appropriate. Lower forms of accepted evidence include cohort studies, case control studies, case series and case reports, and last, expert opinion--all of which can be potentially instructive. The hallmark of evidence-based treatment is not so much the reliance on evidence in general, but to use the best available evidence relative to the particular patient, the clinical setting and surgeon experience. Correctly applied, varying forms of evidence each have a role in aiding surgeons offer appropriate care for their patients--to help them best fix the fracture.

  1. Principle design and data of graphite components

    International Nuclear Information System (INIS)

    The High Temperature Engineering Test Reactor (HTTR) constructed by Japan Atomic Energy Research Institute (JAERI) is a graphite-moderated and helium-gas-cooled reactor with prismatic fuel elements of hexagonal blocks. The reactor internal structures of the HTTR are mainly made up of graphite components. As well known, the graphite is a brittle material and there were no available design criteria for brittle materials. Therefore, JAERI had to develop the design criteria taking account of the brittle fracture behavior. In this paper, concept and key specification of the developed graphite design criteria is described, and also an outline of the quality control specified in the design criteria is mentioned

  2. Toward Instructional Design Principles: Inducing Faraday's Law with Contrasting Cases

    Science.gov (United States)

    Kuo, Eric; Wieman, Carl E.

    2016-01-01

    Although physics education research (PER) has improved instructional practices, there are not agreed upon principles for designing effective instructional materials. Here, we illustrate how close comparison of instructional materials could support the development of such principles. Specifically, in discussion sections of a large, introductory…

  3. Robust design principles for reducing variation in functional performance

    DEFF Research Database (Denmark)

    Christensen, Martin Ebro; Howard, Thomas J.

    2016-01-01

    and perceived quality of a product and efforts should be made to minimise it. The design principles are identified by a systematic decomposition of the Taguchi Transfer Function in combination with the use of existing literature and the authors’ experience. The paper presents 15 principles and describes...

  4. Design Principles for Achieving Integrated Healthcare Information Systems

    DEFF Research Database (Denmark)

    Jensen, Tina Blegind

    2013-01-01

    and Lyytinen, to examine the design principles that facilitated this smallscale project to expand and become widespread. As a result of my findings, I outline three lessons learned that emphasize: (i) principles of flexibility, (ii) expansion from the installed base through modular strategies and (iii...

  5. Effective motion design applied to energy-efficient handling processes

    Energy Technology Data Exchange (ETDEWEB)

    Brett, Tobias

    2013-10-01

    Industrial robots are available in a large variety of mechanical alternatives regarding size, motor power, link length ratio or payload. The four major types of serial kinematics dominating the market are complemented by various parallel kinematics for special purpose. In contrast, few other path planning alternatives are applied in industrial robotics which are based on similar analytic solution principles. The objective of this thesis is to develop a systematic design method for artifacts in motion, to integrate motion design and mechanical design to enable new processes for production. For each design, a theoretical benchmark is developed, which cannot be attained by conventional robots in principle. A key performance indicator enables to measure the degree of goal achievement towards the benchmark during all design phases. Motion behaviors are identified on a local level by dynamic systems modeling and are integrated into new global behavior featuring a new quality, suitable for exceeding the design benchmark in industrial processes. Two exemplary handling robot designs are presented. The first concept enables motion behavior to consume less electrical power than kinetic energy transferred to and from its payload during motion. The second concept enables motion with four degrees of freedom by single motor stimulation, reducing idle power consumption on factor 4 towards conventional robots.

  6. Publish Subscribe Systems Design and Principles

    CERN Document Server

    Tarkoma, Sasu

    2012-01-01

    This book offers an unified treatment of the problems solved by publish/subscribe, how to design and implement the solutions In this book, the author provides an insight into the publish/subscribe technology including the design, implementation, and evaluation of new systems based on the technology.  The book also addresses the basic design patterns and solutions, and discusses their application in practical application scenarios. Furthermore, the author examines current standards and industry best practices as well as recent research proposals in the area. Finally, necessary content ma

  7. Design principles and outcomes of peer assessment in higher education

    NARCIS (Netherlands)

    van den Berg, I.; Admiraal, W.; Pilot, A.

    2006-01-01

    Design principles and outcomes of peer assessment in higher education This study aims to find effective designs of peer assessment of written assignments in the context of university teaching. To discover features yielding optimal results, several designs of peer assessment were developed, implement

  8. Applied statistical designs for the researcher

    CERN Document Server

    Paulson, Daryl S

    2003-01-01

    Showcasing a discussion of the experimental process and a review of basic statistics, this volume provides methodologies to identify general data distribution, skewness, and outliers. It features a unique classification of the nonparametric analogs of their parametric counterparts according to the strength of the collected data. Applied Statistical Designs for the Researcher discusses three varieties of the Student t test, including a comparison of two different groups with different variances; two groups with the same variance; and a matched, paired group. It introduces the analysis of variance and Latin Square designs and presents screening approaches to comparing two factors and their interactions.

  9. Design principles for radiological protection instrumentation systems

    International Nuclear Information System (INIS)

    This Code of Practice takes the form of recommendations intended for designers and installers of Radiological Protection Instrumentation, and should also be of value to the newcomer to the R.P.I. field. Topics are discussed under the following headings: outline of R.P.I. requirements, specifying the requirement, satisfying the requirements, (overall design, availability and reliability, information display, human factors, power supplies, manufacture, quality assurance, testing, and cost analysis), supply, location and operation of the equipment, importance of documentation. (U.K.)

  10. Principles of waveform diversity and design

    CERN Document Server

    Wicks, Michael

    2011-01-01

    This is the first book to discuss current and future applications of waveform diversity and design in subjects such as radar and sonar, communications systems, passive sensing, and many other technologies. Waveform diversity allows researchers and system designers to optimize electromagnetic and acoustic systems for sensing, communications, electronic warfare or combinations thereof. This book enables solutions to problems, explaining how each system performs its own particular function, as well as how it is affected by other systems and how those other systems may likewise be affected. It is

  11. Wireless sensor networks principles, design and applications

    CERN Document Server

    Yang, Shuang-Hua

    2014-01-01

    Wireless Sensor Networks presents the latest practical solutions to the design issues presented in wireless-sensor-network-based systems. Novel features of the text, distributed throughout, include workable solutions, demonstration systems and case studies of the design and application of wireless sensor networks (WSNs) based on the first-hand research and development experience of the author, and the chapters on real applications: building fire safety protection; smart home automation; and logistics resource management. Case studies and applications illustrate the practical perspectives of: ·         sensor node design; ·         embedded software design; ·         routing algorithms; ·         sink node positioning; ·         co-existence with other wireless systems; ·         data fusion; ·         security; ·         indoor location tracking; ·         integrating with radio-frequency identification; and ·         In...

  12. Principles and Design Rationale of Composition Filters

    NARCIS (Netherlands)

    Bergmans, Lodewijk; Aksit, Mehmet; Filman, Robert E.; Elrad, Tzilla; Clarke, Siobhán; Akşit, Mehmet

    2004-01-01

    A wide range of aspect-oriented programming languages has appeared in the past years [7]. Current research on future generation AOP languages is addressing issues like flexibility, expressive power and safety. We think that it is important to understand the motivations and design decisions of the fi

  13. Models and design principles for teacher research

    NARCIS (Netherlands)

    Admiraal, Wilfried; Smit, Ben; Zwart, Rosanne

    2014-01-01

    Teacher research is a way to bridge the gap between theory and teaching practice. Various types of teacher research can be distinguished, including most commonly: action research, selfstudy, lesson study, design-based research, and scholarship of teaching and learning. All types of teacher research

  14. Applying lean management principles to the creation of a postpartum hemorrhage care bundle.

    Science.gov (United States)

    Faulkner, Beth

    2013-10-01

    A lean management process is a set of interventions, each of which creates value for the customer. Lean management is not a new concept, but is relatively new to health care. Postpartum hemorrhage (PPH) is the most common cause of maternal death worldwide in both developing and developed countries. We applied lean management principles as an innovative approach to improving outcomes in patients with PPH. Initial results using principles of lean management indicated significant improvements in response time and family-centered care. When applied rigorously and throughout the organization, lean principles can have a dramatic effect on productivity, cost and quality. PMID:24138659

  15. Applying lean management principles to the creation of a postpartum hemorrhage care bundle.

    Science.gov (United States)

    Faulkner, Beth

    2013-10-01

    A lean management process is a set of interventions, each of which creates value for the customer. Lean management is not a new concept, but is relatively new to health care. Postpartum hemorrhage (PPH) is the most common cause of maternal death worldwide in both developing and developed countries. We applied lean management principles as an innovative approach to improving outcomes in patients with PPH. Initial results using principles of lean management indicated significant improvements in response time and family-centered care. When applied rigorously and throughout the organization, lean principles can have a dramatic effect on productivity, cost and quality.

  16. Design principles of metal-cutting machine tools

    CERN Document Server

    Koenigsberger, F

    1964-01-01

    Design Principles of Metal-Cutting Machine Tools discusses the fundamentals aspects of machine tool design. The book covers the design consideration of metal-cutting machine, such as static and dynamic stiffness, operational speeds, gearboxes, manual, and automatic control. The text first details the data calculation and the general requirements of the machine tool. Next, the book discusses the design principles, which include stiffness and rigidity of the separate constructional elements and their combined behavior under load, as well as electrical, mechanical, and hydraulic drives for the op

  17. Design principles for efficient, repeated jumpgliding

    International Nuclear Information System (INIS)

    Combined jumping and gliding locomotion, or ‘jumpgliding’, can be an efficient way for small robots or animals to travel over cluttered terrain. This paper presents functional requirements and models for a simple jumpglider which formalize the benefits and limitations of using aerodynamic surfaces to augment jumping ability. Analysis of the model gives insight into design choices and control strategies for higher performance and to accommodate special conditions such as a slippery launching surface. The model informs the design of a robotic platform that can perform repeated jumps using a carbon fiber spring and a pivoting wing. Experiments with two different versions of the platform agree with predictions from the model and demonstrate a significantly greater range, and lower cost-of-transport, than a comparable ballistic jumper. (papers)

  18. Principle of equipartition of entransy dissipation for heat exchanger design

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    In the present work,a principle of equipartition of entransy dissipation(EoED) for heat exchanger design is established,which says that for a heat exchanger design with given heat duty and heat transfer area,the total entransy dissipation rate reaches the minimum when the local entransy dissipation rate is uniformly distributed along the heat exchanger.When the heat transfer coefficient is unfixed,the total entransy dissipation obtained by the EoED principle is less than that obtained by the principle of equipartition of temperature difference(EoTD).Furthermore,the exchanger effectiveness obtained by the EoED principle is larger than that obtained by the EoTD principle.When the heat transfer coefficient is fixed,the EoED principle is equivalent to the EoTD principle.We show that the equipartition of entropy production(EoEP) and EoED principles give rise to difference in entropy generation and entransy dissipation for a heat exchanger optimization design.The discrepancies are caused by distinct features of entropy production minimization and entransy dissipation minimization principles,the former is to optimize the design of heat exchanger by making the lost available work minimum,while the latter is not involved with heat-work conversion.It is found that the entropy generation number is not suitable for evaluating heat exchanger performance,since it directly depends on the inlet and outlet temperatures of working fluids.On the contrary,the entransy dissipation number is not directly related to the inlet and outlet temperatures of working fluids.Therefore,the entransy dissipation number is more suitable for serving as a criterion to evaluate heat exchanger performance.

  19. Wind turbine technology principles and design

    CERN Document Server

    Adaramola, Muyiwa

    2014-01-01

    IntroductionPart I: AerodynamicsWind Turbine Blade Design; Peter J. Schubel and Richard J. CrossleyA Shrouded Wind Turbine Generating High Output Power with Wind-Lens Technology; Yuji Ohya and Takashi KarasudaniEcomoulding of Composite Wind Turbine Blades Using Green Manufacturing RTM Process; Brahim AttafAerodynamic Shape Optimization of a Vertical-Axis Wind Turbine Using Differential Evolution; Travis J. Carrigan, Brian H. Dennis, Zhen X. Han, and Bo P. WangPart II: Generators and Gear Systems

  20. Preserving SSC Design Function Using RCM Principles

    International Nuclear Information System (INIS)

    Reliability-Centered Maintenance (RCM) can be defined as an approach that employs preventive, predictive, proactive, and reactive maintenance practices and strategies in an integrated manner to increase the probability that a Structure, System, or Component (SSC) will function as designed over its life cycle with optimum maintenance. The goal of RCM is to preserve the SSC intended design function at the lowest cost by developing a maintenance strategy that is supported by sound technical and economic justification. RCM has been used extensively by the aircraft, space, defense, power generation, and manufacturing industries where functional failures of SSCs can have the potential to compromise worker or public safety, cause adverse environmental impact, cause loss of production, and/or result in excessive damage to critical SSCs. This paper provides a framework for performing an RCM analysis in support of DOE Order 430.1A (Life Cycle Asset Management) and DOE Order 420.1B (Facility Safety). The influence of RCM on the various aspects of the maintenance program including the work control process is also discussed

  1. Applying the Principles of Systems Engineering and Project Management to Optimize Scientific Research

    Science.gov (United States)

    Peterkin, Adria J.

    2016-01-01

    Systems Engineering is an interdisciplinary practice that analyzes different facets of a suggested area to properly develop and design an efficient system guided by the principles and restrictions of the science community. When entering an institution with quantitative and analytical scientific theory it is important to make sure that all parts of a system correlates in a structured and systematic manner so that all areas of intricacy will be prevented or quickly deduced. My research focused on interpreting and implementing Systems Engineering techniques in the construction, integration and operation of a NASA Radio Jove Kit to Observe Jupiter radio emissions. Jupiter emissions read at very low frequencies so when building the telescope it had to be able to read less than 39.5 MHz. The projected outcome was to receive long L-bursts and short S-burts signals; however, during the time of observation Jupiter was in conjunction with the Sun. We then decided to use the receiver built from the NASA Radio Jove Kit to hook it up to the Karl Jansky telescope to make an effort to listen to solar flares as well, nonetheless, we were unable to identify these signals and further realized they were noise. The overall project was a success in that we were able to apply and comprehend, the principles of Systems Engineering to facilitate the build.

  2. Software Design Principles to Enhance SDN Architecture

    Directory of Open Access Journals (Sweden)

    Iyad Alazzam

    2016-08-01

    Full Text Available SDN as a network architecture emerged on top of existing technologies and knowledge. Through defining the controller as a software program, SDN made a strong connection between networking and software engineering. Traditionally, network programs were vendor specific and embedded in hardware switches and routers. SDN focuses on isolation between control and forwarding or data planes. However, in the complete SDN network, there are many other areas (i.e. CPU, memory, hardware, bandwidth and software. In this paper, we propose extending SDN architecture and propose isolation layers with the goal of improving the overall network design. Such flexible architecture can support future evolution and changes without the need to significantly change original components or modules.

  3. PRINCIPLE OF POST-PRODUCTION DESIGN OF HYDRAULIC ACTUATORS

    OpenAIRE

    A. V. Puzanov

    2015-01-01

    In work the problem of design-technology preparation of production of hydraulic actuators is staticized. The structure and business processes of design and production are analysed. Methods and means of reorganization of project works for the purpose of cutting-down of time of preparation of production are offered. The directions of reorganization of process of design are formulated. The principle of carrying out procedures of design-technology preparation of production of hydraulic actuators ...

  4. Design of the optocoupler applied to medical lighting systems.

    Science.gov (United States)

    Yang, Xibin; Lit, Rui; Zhu, Jianfeng; Xiong, Daxi

    2012-12-01

    A new type of optocoupler applied to medical lighting system is proposed, and the principle, Etendue and design process is introduced. With the help of Tracrpro, modeling and simulation of the optocoupler is conducted and the parameters are optimized. Analysis of factors affecting the energy coupling efficiency is done. With a view towards the development of Ultra High Brightness Light Emitting Diodes (UHB-LEDs), which play an important role a new sources of lighting in various biomedical devices, including those used in diagnosis and treatment, a series of simulations are executed and a variety of solutions are achieved. According to simulation results, the design target of coupling efficiency is achieved and the optical uniformity is also significantly improved. According to the result of theoretical analysis, verification experiments are designed and simulation results are verified. The optocoupler, which has simple structure, compact size and low cost, is suitable for applications in the field of low-cost medical domain.

  5. Engineering Design of an Adaptive Leg Prosthesis Using Biological Principles

    DEFF Research Database (Denmark)

    Lenau, Torben Anker; Dentel, Andy; Invarsdottir, Thorunn;

    2010-01-01

    The biomimetic design process is explored through a design case: An adaptive leg prosthesis. The aim is to investigate if the biomimetic design process can be carried out with a minimum of biological knowledge and without using advanced design methods. In the design case biomimetic design was suc...... was successfully carried out using library search resulting in 14 biological analogies for the design problem 'shape adaption'. It is proposed that search results are handled using special cards describing the biological phenomena and the functional principles....

  6. Principle design of an energy efficient transfemoral prosthesis

    NARCIS (Netherlands)

    Ünal, R.; Hekman, E.E.G.; Carloni, R.; Koopman, H.F.J.M.; Stramigioli, S.

    2009-01-01

    In the pursuit of realizing an energy efficient transfemoral prosthetic, in this paper we present a preliminary study on a principle design. In particular, the design is based on the idea that the efficiency of the system can be realized by energetically coupling the knee and the ankle joints. In or

  7. The Origins of Graphic Screen Design Principles Theory or Rhetoric?

    Science.gov (United States)

    International Journal of Instructional Media, 2005

    2005-01-01

    Trainers have long relied on visuals to make their training more effective. This paper explores whether or not graphic design principles, commonly employed by trainers in presentations and Web-based training modules, influence the learning process. A review of the core works in the field of instructional design reveals that most of the principles…

  8. [Design principles of the POLIMAG-01 basic model].

    Science.gov (United States)

    Kabishev, V N; Kadyrkov, A P; Makarov, V V; Mikheev, A A; Panin, N I; Solomakha, V N

    2007-01-01

    The design principles and functional capabilities of the basic model of the POLIMAG-01 magnetotherapy apparatus are described. Technical characteristics of the apparatus are specified. Original engineering solutions involved in the apparatus design provide local, distributed, and general magnetotherapy. PMID:18277402

  9. Instructional Audio Guidelines: Four Design Principles to Consider for Every Instructional Audio Design Effort

    Science.gov (United States)

    Carter, Curtis W.

    2012-01-01

    This article contends that instructional designers and developers should attend to four particular design principles when creating instructional audio. Support for this view is presented by referencing the limited research that has been done in this area, and by indicating how and why each of the four principles is important to the design process.…

  10. Patterns, principles, and practices of domain-driven design

    CERN Document Server

    Millett, Scott

    2015-01-01

    Methods for managing complex software construction following the practices, principles and patterns of Domain-Driven Design with code examples in C# This book presents the philosophy of Domain-Driven Design (DDD) in a down-to-earth and practical manner for experienced developers building applications for complex domains. A focus is placed on the principles and practices of decomposing a complex problem space as well as the implementation patterns and best practices for shaping a maintainable solution space. You will learn how to build effective domain models through the use of tactical pat

  11. Principle and Method for Structural Design of Digital Woven Fabric

    Institute of Scientific and Technical Information of China (English)

    ZHOU Jiu; NG Frankie

    2006-01-01

    Digital woven textiles are one of the latest research areas of digital textiles. The key of research on design of digital woven fabrics lies in structural design. Nowadays, the application of digital design technology has fundamentally changed the concept of structural design of woven fabric,giving rise to design methods and effects that were deemed impossible before. A study has been carried out to analyze the nature of woven structures and the methods of structural design. This paper proposes an innovative principle and method of structural design under digital design concept, on which the design of digital gamut weaves and establishment of weave-database were presented to meet the requirement of balanced interlacement. It is envisaged that the results of this study will enhance future research in creation of digital woven fabrics, with particular emphasis on digital jacquard fabrics. Meanwhile, this study is also laid the foundation for the intelligent design of woven textile.

  12. Student design projects in applied acoustics.

    Science.gov (United States)

    Bös, Joachim; Moritz, Karsten; Skowronek, Adam; Thyes, Christian; Tschesche, Johannes; Hanselka, Holger

    2012-03-01

    This paper describes a series of student projects which are intended to complement theoretical education in acoustics and engineering noise control with practical experience. The projects are also intended to enhance the students' ability to work in a team, to manage a project, and to present their results. The projects are carried out in close cooperation with industrial partners so that the students can get a taste of the professional life of noise control engineers. The organization of such a project, its execution, and some of the results from the most recent student project are presented as a demonstrative example. This latest project involved the creation of noise maps of a production hall, the acoustic analysis of a packaging machine, and the acoustic analysis of a spiral vibratory conveyor. Upon completion of the analysis, students then designed, applied, and verified some simple preliminary noise reduction measures to demonstrate the potential of these techniques.

  13. Student design projects in applied acoustics.

    Science.gov (United States)

    Bös, Joachim; Moritz, Karsten; Skowronek, Adam; Thyes, Christian; Tschesche, Johannes; Hanselka, Holger

    2012-03-01

    This paper describes a series of student projects which are intended to complement theoretical education in acoustics and engineering noise control with practical experience. The projects are also intended to enhance the students' ability to work in a team, to manage a project, and to present their results. The projects are carried out in close cooperation with industrial partners so that the students can get a taste of the professional life of noise control engineers. The organization of such a project, its execution, and some of the results from the most recent student project are presented as a demonstrative example. This latest project involved the creation of noise maps of a production hall, the acoustic analysis of a packaging machine, and the acoustic analysis of a spiral vibratory conveyor. Upon completion of the analysis, students then designed, applied, and verified some simple preliminary noise reduction measures to demonstrate the potential of these techniques. PMID:22423803

  14. DATA CRYSTALLIZATION APPLIED FOR DESIGNING NEW PRODUCTS

    Institute of Scientific and Technical Information of China (English)

    Kenichi HORIE; Yoshiharu MAENO; Yukio OHSAWA

    2007-01-01

    It is only the observable part of the real world that can be stored in data.For such incomplete and ill-structured data,data crystallizing aims at presenting the hidden structure among events including unobservable events.This is realized by data crystallization,where dummy items,corresponding to potential existence ofunobservable events,are inserted to the given data.These dummy items and their relations with observable events are visualized by applying KeyGraph to the data with dummy items,like the crystallization of snow where dusts are involved in the formation of crystallization of water molecules.For tuning the granularity level of structure to be visualized,the tool of data crystallization is integrated with human's process of understanding significant scenarios in the real world.This basic method is expected to be applicable for various real world domains where previous methods of chance-discovery lead human to successful decision making.In this paper,we apply the data crystallization with human-interactive annealing (DCHA) to the design of products in a real company.The results show its effect to industrial decision making.

  15. Evaluating Educational Software Authoring Environments Using a Model Based on Software Engineering and Instructional Design Principles.

    Science.gov (United States)

    Collis, Betty A.; Gore, Marilyn

    1987-01-01

    This study suggests a new model for the evaluation of educational software authoring systems and applies this model to a particular authoring system, CSR Trainer 4000. The model used is based on an integrated set of software engineering and instructional design principles. (Author/LRW)

  16. Applying Software Design Patterns on iOS Application : A Case Study: Finnkino

    OpenAIRE

    Atik, Mohammad Abdullah

    2014-01-01

    Software developers practice software design patterns and principles to solve commonly occurring problems while ensuring extensible robust and maintainable system. The thesis aimed to study a subset of software patterns and principles. The practical goal of the thesis was to develop an iOS application with proper patterns applied. The main focus was to recognize which pattern would suit for an application’s various design challenges and what benefits would be harnessed by it. The study ai...

  17. The principle of double effect applied to ethical dilemmas of social robots

    DEFF Research Database (Denmark)

    Bentzen, Martin Mose

    2016-01-01

    The introduction of social robots into society will require that they follow ethical principles which go beyond consequentialism. In this paper, I show how to apply the principle of double effect to solve an ethical dilemma involving robots studied by Alan Winfield and colleagues. The principle...... of double effect states conditions for ethically acceptable behavior when there are both positive and negative consequences of an action. I propose a formal semantics with actions, causes, intentions, and utilities based upon the work of Judea Pearl, John Horty, and others. With this formal semantics......, the question of whether an action is permitted according to the principle of double effect is reduced to deciding whether a certain formula is true or otherwise....

  18. Design Principles for Cell Phone Learning in EFL

    Science.gov (United States)

    Wang, Feihong

    2010-01-01

    Cell phone learning (C-learning), as an instructional approach, has been gaining more and more attention in the field of teaching English as a foreign language (EFL) in the last 10 years. While studies have proved C-learning an effective instructional approach in research settings, a review of literature indicates the lack of design principles to…

  19. Design Principles for Improving the Process of Publishing Open data

    NARCIS (Netherlands)

    Zuiderwijk, A.M.G.; Janssen, M.F.W.H.A.; Choenni, R. .; Meijer, R.F.

    2014-01-01

    · Purpose: Governments create large amounts of data. However, the publication of open data is often cumbersome and there are no standard procedures and processes for opening data. This blocks the easy publication of government data. The purpose of this paper is to derive design principles for improv

  20. Virtual Worlds; Real Learning: Design Principles for Engaging Immersive Environments

    Science.gov (United States)

    Wu (u. Sjarpm)

    2012-01-01

    The EMDT master's program at Full Sail University embarked on a small project to use a virtual environment to teach graduate students. The property used for this project has evolved our several iterations and has yielded some basic design principles and pedagogy for virtual spaces. As a result, students are emerging from the program with a better grasp of future possibilities.

  1. 39 CFR 3050.10 - Analytical principles to be applied in the Postal Service's annual periodic reports to the...

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Analytical principles to be applied in the Postal... REGULATORY COMMISSION PERSONNEL PERIODIC REPORTING § 3050.10 Analytical principles to be applied in the... Commission, the Postal Service shall use only accepted analytical principles. With respect to its...

  2. Computers as components principles of embedded computing system design

    CERN Document Server

    Wolf, Marilyn

    2012-01-01

    Computers as Components: Principles of Embedded Computing System Design, 3e, presents essential knowledge on embedded systems technology and techniques. Updated for today's embedded systems design methods, this edition features new examples including digital signal processing, multimedia, and cyber-physical systems. Author Marilyn Wolf covers the latest processors from Texas Instruments, ARM, and Microchip Technology plus software, operating systems, networks, consumer devices, and more. Like the previous editions, this textbook: Uses real processors to demonstrate both technology and tec

  3. Design for social innovation: emerging principles and approaches

    OpenAIRE

    Chick, Anne

    2012-01-01

    Anne Chick’s essay ‘Design for social innovation: emerging principles and approaches’, rounds off this collection by addressing key challenges that we all face as designers in embedding social- and bio-sustainability in our practices. She asks us to consider the complex social issues in this emerging new research landscape and what strategies, tools, methods and collaborations are needed to be effective participants in providing solutions and meaningful policy changes.

  4. Some Novel Design Principles for Collective Behaviors in Mobile Robots

    Energy Technology Data Exchange (ETDEWEB)

    OSBOURN, GORDON C.

    2002-09-01

    We present a set of novel design principles to aid in the development of complex collective behaviors in fleets of mobile robots. The key elements are: the use of a graph algorithm that we have created, with certain proven properties, that guarantee scalable local communications for fleets of arbitrary size; the use of artificial forces to simplify the design of motion control; the use of certain proximity values in the graph algorithm to simplify the sharing of robust navigation and sensor information among the robots. We describe these design elements and present a computer simulation that illustrates the behaviors readily achievable with these design tools.

  5. The Levels of Conceptual Interoperability Model: Applying Systems Engineering Principles to M&S

    CERN Document Server

    WANG, Wenguang; WANG, Weiping

    2009-01-01

    This paper describes the use of the Levels of Conceptual Interoperability Model (LCIM) as a framework for conceptual modeling and its descriptive and prescriptive uses. LCIM is applied to show its potential and shortcomings in the current simulation interoperability approaches, in particular the High Level Architecture (HLA) and Base Object Models (BOM). It emphasizes the need to apply rigorous engineering methods and principles and replace ad-hoc approaches.

  6. Does the modality principle for multimedia learning apply to science classrooms?

    NARCIS (Netherlands)

    Harskamp, Egbert G.; Mayer, Richard E.; Suhre, Cor

    2007-01-01

    This study demonstrated that the modality principle applies to multimedia learning of regular science lessons in school settings. In the first field experiment, 27 Dutch secondary school students (age 16-17) received a self-paced, web-based multimedia lesson in biology. Students who received lessons

  7. Applying principles of Design For Assembly to ITER maintenance operations

    NARCIS (Netherlands)

    Heemskerk, C.; de M. Baar,; Elzendoorn, B.; Koning, J.; Verhoeven, T.; de Vreede, F.

    2009-01-01

    In ITER, maintenance operations in the vessel and in the Hot Cell will be largely done by Remote Handling (RH). Remotely performed maintenance actions tend to be more time-costly than actions performed by direct human access. With a human operator in the control loop and adequate situational feedbac

  8. Applying Operating System Principles to SDN Controller Design

    OpenAIRE

    Monaco, Matthew; Michel, Oliver; Keller, Eric

    2015-01-01

    Rather than creating yet another network controller which provides a framework in a specific (potentially new) programming language and runs as a monolithic application, in this paper we extend an existing operating system and leverage its software ecosystem in order to serve as a practical SDN controller. This paper introduces yanc, a controller platform for software-defined networks which exposes the network configuration and state as a file system, enabling user and system applications to ...

  9. Innovative Principle and Method for Digital Jacquard Fabric Designing

    Institute of Scientific and Technical Information of China (English)

    ZHOU Jiu; NG Fran-kie; SZETO Y C; HUI C L

    2007-01-01

    Digital jacquard fabric has its design concept and method directly borrowed from computer images and color modes, which enabled creation of jacquard fabric design that is far beyond what freehand patterns can express. In this paper, the principles of digital jacquard fabric design were classified into two parts: colorless mode and colorful mode, and an innovative layered combination design method has been suggested contenting with this new design concept, by which digital jacquard fabric can be designed from colorless single-layer structure to colorful compound structure. As a result, designed colorless and colorful jacquard fabrics are capable of expressing picturesque and photo-realistic effects with a mega level color number on face of fabric. It is envisaged that the results of the study are of tremendous benefit to the creation of new jacquard fabric ith an inimitable digital effect and this creation pose no problem in mass production.

  10. Design Principles for Effective Knowledge Discovery from Big Data

    Energy Technology Data Exchange (ETDEWEB)

    Begoli, Edmon [ORNL; Horey, James L [ORNL

    2012-01-01

    Big data phenomenon refers to the practice of collection and processing of very large data sets and associated systems and algorithms used to analyze these massive datasets. Architectures for big data usually range across multiple machines and clusters, and they commonly consist of multiple special purpose sub-systems. Coupled with the knowledge discovery process, big data movement offers many unique opportunities for organizations to benefit (with respect to new insights, business optimizations, etc.). However, due to the difficulty of analyzing such large datasets, big data presents unique systems engineering and architectural challenges. In this paper, we present three sys- tem design principles that can inform organizations on effective analytic and data collection processes, system organization, and data dissemination practices. The principles presented derive from our own research and development experiences with big data problems from various federal agencies, and we illustrate each principle with our own experiences and recommendations.

  11. Theory-generating practice. Proposing a principle for learning design

    DEFF Research Database (Denmark)

    Buhl, Mie

    2016-01-01

    This contribution proposes a principle for learning design – Theory-Generating Practice (TGP) – as an alternative to the way university courses are traditionally taught and structured, with a series of theoretical lectures isolated from practical experience and concluding with an exam or a project...... building, and takes tacit knowledge into account. The article introduces TGP, contextualizes it to a Danish tradition of didactics, and discusses it in relation to contemporary conceptual currents of didactic design and learning design. This is followed by a theoretical framing of TGP. Finally, three...

  12. Rational principles of compound selection for combinatorial library design.

    Science.gov (United States)

    Tropsha, Alexander; Zheng, Weifan

    2002-03-01

    It is practically impossible in a short period of time to synthesize and test all compounds in any large exhaustive chemical library. We discuss rational approaches to selecting representative subsets of virtual libraries that help direct experimental synthetic efforts for both targeted and diverse library design. For targeted library design, we consider principles based on the similarity to lead molecules. In the case of diverse library design, we discuss algorithms aimed at the selection of both diverse and representative subsets of the entire chemical library space. We illustrate methodologies with several practical examples.

  13. Applying design thinking elsewhere: Organizational context matters

    NARCIS (Netherlands)

    Smulders, F.E.H.M.; Dorst, K.; Vermaas, P.E.

    2014-01-01

    In this contribution design thinking is taken as a transfer of design methods from product development to other domains. It is argued that the success of this transfer depends on the organisational context offered to design thinking in these other domains. We describe the application of design metho

  14. Applying the V Model and Axiomatic Design in the Domain of IT Architecture Practice

    NARCIS (Netherlands)

    Tarenskeen, Debbie; Bakker, René; Joosten, Stef

    2015-01-01

    This paper applies and discusses the principles of Axiomatic Design for changing IT architecture in health care. It presents three case studies positioned in the field of Enterprise architecture that explore how IT architects, as professionals, manage change and re-design the structure of the IT sys

  15. Sustaining Academic Life: A Case for Applying Principles of Social Sustainability to the Academic Profession

    Science.gov (United States)

    Hammond, Cathryn; Churchman, Deborah

    2008-01-01

    Purpose: This paper aims to examine the social sustainability of academic work in Australian tertiary institutions, in addition to offering a summary of recent research on social sustainability with a particular emphasis on Barron and Gauntlett's work. Design/methodology/approach: Barron and Gauntlett's principles of social sustainability are used…

  16. Zero Energy Buildings – Design Principles and Built Examples

    DEFF Research Database (Denmark)

    for the development of zero energy houses. These strategies and technologies are illustrated through simple design principles and built examples • identify technical and architectural potentials and challenges related to design strategies of crucial importance to the development of zero energy houses • identify......Designing a zero energy building is a complicated task, and in order to achieve good results it is necessary to include knowledge from a range of sources. Therefore, cooperation is required between different professions and between generalists and specialists from the very beginning of the process...... knowledge must be acquired, depending on the project in question. Through a cross-disciplinary approach to architecture and building design, and based on an integrated design process, this publication will: • introduce a number of design strategies and technologies which are particularly important...

  17. Digital sonar design in underwater acoustics principles and applications

    CERN Document Server

    Li, Qihu

    2012-01-01

    "Digital Sonar Design in Underwater Acoustics Principles and Applications" provides comprehensive and up-to-date coverage of research on sonar design, including the basic theory and techniques of digital signal processing, basic concept of information theory, ocean acoustics, underwater acoustic signal propagation theory, and underwater signal processing theory. This book discusses the general design procedure and approaches to implementation, the design method, system simulation theory and techniques, sonar tests in the laboratory, lake and sea, and practical validation criteria and methods for digital sonar design. It is intended for researchers in the fields of underwater signal processing and sonar design, and also for navy officers and ocean explorers. Qihu Li is a professor at the Institute of Acoustics, Chinese Academy of Sciences, and an academician of the Chinese Academy of Sciences.

  18. Design principles of a web interface for monitoring tools

    Energy Technology Data Exchange (ETDEWEB)

    Aiftimiei, C; Pra, S D; Fantinel, S [INFN-Padova, Padova (Italy); Andreozzi, S; Fattibene, E; Misurelli, G [INFN-CNAF, Bologna (Italy); Cuscela, G; Donvito, G; Dudhalkar, V; Maggi, G; Pierro, A [INFN-Bari, Bari (Italy)], E-mail: giuseppe.misurelli@cnaf.infn.it, E-mail: enrico.fattibene@cnaf.infn.it

    2008-07-15

    A monitoring tool of a complex Grid system can gather a huge amount of information that have to be presented to the users in the most comprehensive way. Moreover different types of consumers could be interested in inspecting and analyzing different subsets of data. The main goal in designing a Web interface for the presentation of monitoring information is to organize the huge amount of data in a simple, user-friendly and usable structure. One more problem is to consider different approaches, skills and interests that all the possible categories of users have in looking for the desired information. Starting from the Information Architecture guidelines for the Web, it is possible to design Web interfaces towards a closer user experience and to deal with an advanced user interaction through the implementation of many Web standard technologies. In this paper, we will present a number of principles for the design of Web interface for monitoring tools that provide a wider, richer range of possibilities for what concerns the user interaction. These principles are based on an extensive review of the current literature in Web design and on the experience with the development of the GridICE monitoring tool. The described principles can drive the evolution of the Web interface of Grid monitoring tools.

  19. Using Persuasive Design Principles in Motivational Feeling towards Children Dental Anxiety (CDA)

    Science.gov (United States)

    Salam, Sobihatun Nur-Abdul; Yahaya, Wan Ahmad Jaafar-Wan; Ali, Azillah-Mohd

    This paper is focusing the potential use of persuasive design principles in motivating children's dental anxiety. The main intention of the paper is to emphasize an attempt of how persuasive design principle can be designed into educational material using CD ROM based multimedia learning environment to overcome the CDA. Firstly, we describe a problem domain which discuss about the universal feeling of CDA and secondly the current practices in handling those negative feelings. Thirdly, the conceptual background of PMLE and how the principle has been applied in designing the information interfaces and presentation of a persuasive multimedia learning environment (PMLE) are described. Fourthly, an experimental design was used to validate the effects of prototype which assessed children dental anxiety level before and after the demonstration and utilization of a PMLE. Primary school children age between seven and nine years old are selected as respondents. Fifthly, the result of the study has revealed the feedback from children regarding baseline test and children dental anxiety test. It shows how by using persuasive design principles as an overall strategy in designing PMLE was able to motivate children feelings towards dental anxiety and could let the children behave in a good manner for dental visit in the future.

  20. Client Mobile Software Design Principles for Mobile Learning Systems

    Directory of Open Access Journals (Sweden)

    Qing Tan

    2009-01-01

    Full Text Available In a client-server mobile learning system, client mobile software must run on the mobile phone to acquire, package, and send student’s interaction data via the mobile communications network to the connected mobile application server. The server will receive and process the client data in order to offer appropriate content and learning activities. To develop the mobile learning systems there are a number of very important issues that must be addressed. Mobile phones have scarce computing resources. They consist of heterogeneous devices and use various mobile operating systems, they have limitations with their user/device interaction capabilities, high data communications cost, and must provide for device mobility and portability. In this paper we propose five principles for designing Client mobile learning software. A location-based adaptive mobile learning system is presented as a proof of concept to demonstrate the applicability of these design principles.

  1. Greenhouse design applying CFD for Indonesian conditions

    NARCIS (Netherlands)

    Campen, J.B.

    2005-01-01

    In the design phase of a test site in Indonesia computational fluid dynamics has been used to design the construction of the plastic greenhouse. Greenhouses in Indonesia are built to protect the crop from heavy rain and insects. The climate in four different greenhouse designs is calculated without

  2. Instructional design principles for cooperative learning in Asia

    OpenAIRE

    Nguyen, Phuong-Mai; Terlouw, C.; Pilot, A.

    2006-01-01

    Social sciences possess a plethora of studies about cooperative learning. However, most of these researches have been conducted mainly by and on Westerners with fundamental assumptions based on Western values. Many recent intercultural studies proved that people cooperate with each other differently across cultures. This suggests a need of different model and different design principles for Cooperative Learning(CL) in non-Western cultures. Particular focus of this paper is on Confucian Herita...

  3. The prescriptive quality of 11 design principles for knowledge productivity

    OpenAIRE

    Verdonschot, Suzanne G.M.; Kessels, Joseph W.M.

    2008-01-01

    This study explores the learning processes that contribute to knowledge productivity: gradual improvement and radical innovation of an organisation’s operating procedures, products, and services, based on the development and application of new knowledge. The research is based on the assumption that innovation is the result of a series of powerful social learning processes. Previous research revealed a set of eleven design principles that reflect factors that really matter in an innovation pro...

  4. Power electronics basics operating principles, design, formulas, and applications

    CERN Document Server

    Rozanov, Yuriy; Chaplygin, Evgeny; Voronin, Pavel

    2015-01-01

    Power Electronics Basics: Operating Principles, Design, Formulas, and Applications provides fundamental knowledge for the analysis and design of modern power electronic devices. This concise and user-friendly resource:Explains the basic concepts and most important terms of power electronicsDescribes the power assemblies, control, and passive components of semiconductor power switchesCovers the control of power electronic devices, from mathematical modeling to the analysis of the electrical processesAddresses pulse-width modulation, power quality control, and multilevel, modular, and multicell

  5. Seeing is believing: good graphic design principles for medical research.

    Science.gov (United States)

    Duke, Susan P; Bancken, Fabrice; Crowe, Brenda; Soukup, Mat; Botsis, Taxiarchis; Forshee, Richard

    2015-09-30

    Have you noticed when you browse a book, journal, study report, or product label how your eye is drawn to figures more than to words and tables? Statistical graphs are powerful ways to transparently and succinctly communicate the key points of medical research. Furthermore, the graphic design itself adds to the clarity of the messages in the data. The goal of this paper is to provide a mechanism for selecting the appropriate graph to thoughtfully construct quality deliverables using good graphic design principles. Examples are motivated by the efforts of a Safety Graphics Working Group that consisted of scientists from the pharmaceutical industry, Food and Drug Administration, and academic institutions. PMID:26112209

  6. Seeing is believing: good graphic design principles for medical research.

    Science.gov (United States)

    Duke, Susan P; Bancken, Fabrice; Crowe, Brenda; Soukup, Mat; Botsis, Taxiarchis; Forshee, Richard

    2015-09-30

    Have you noticed when you browse a book, journal, study report, or product label how your eye is drawn to figures more than to words and tables? Statistical graphs are powerful ways to transparently and succinctly communicate the key points of medical research. Furthermore, the graphic design itself adds to the clarity of the messages in the data. The goal of this paper is to provide a mechanism for selecting the appropriate graph to thoughtfully construct quality deliverables using good graphic design principles. Examples are motivated by the efforts of a Safety Graphics Working Group that consisted of scientists from the pharmaceutical industry, Food and Drug Administration, and academic institutions.

  7. Industrial and process furnaces principles, design and operation

    CERN Document Server

    Jenkins, Barrie

    2014-01-01

    Furnaces sit at the core of all branches of manufacture and industry, so it is vital that these are designed and operated safely and effi-ciently. This reference provides all of the furnace theory needed to ensure that this can be executed successfully on an industrial scale. Industrial and Process Furnaces: Principles, 2nd Edition provides comprehensive coverage of all aspects of furnace operation and design, including topics essential for process engineers and operators to better understand furnaces. This includes: the combustion process and its control, furnace fuels, efficiency,

  8. Iterative approach to the Schwinger variational principle applied to electron—molecular-ion collisions

    OpenAIRE

    Lucchese, Robert R.; McKoy, Vincent

    1981-01-01

    We present a study of electron—molecular-ion collisions. The scattering equations are solved using an iterative approach to the Schwinger variational principle. These equations are formulated using the Coulomb Green's function to properly treat the long-range Coulomb tail of the molecular-ion potential. We apply this approach to electron—hydrogen-molecular-ion collisions in the static-exchange approximation. We obtain elastic differential cross sections, and also use the continuum states from...

  9. A Framework for Understanding and Applying Ethical Principles in Network and Security Research

    Science.gov (United States)

    Kenneally, Erin; Bailey, Michael; Maughan, Douglas

    Current information and communications technology poses a variety of ethical challenges for researchers. In this paper, we present an intellectual framework for understanding and applying ethical principles in networking and security research rooted in the guidance suggested by an ongoing Department of Homeland Security working group on ethics. By providing this prototype ethical impact assessment, we seek to encourage community feedback on the working group's nascent efforts and spur researchers to concretely evaluate the ethical impact of their work.

  10. The Logistic Principles for Fast Flexible Strategy Design of the Company in Crisis Time

    Directory of Open Access Journals (Sweden)

    Dušan Malindžák

    2011-06-01

    Full Text Available The article deals with design of the logistic principles enabling an enterpriseto create a strategy flexible in terms of business and marketingand stable and steady in terms of manufacturing. In order to create astrategy model the following principles can be applied: shortening theperiod of capacity planning combined with flexible planning, syncro– MRP (Material Required Planning principle, the application of forecastingin capacity planning, creation with partners of one of the cooperationforms such as supply chain, demand chain, lean supply chain,agile supply chain, leagile supply chain, and using the dbr (Drum BufferRope, APS(Advanced Planning System and SCP (Supply ChainPlanning systems. The article describes application of this principlefor model design of the flexible strategy for Chemosvit fólie a. s. company,and the results of this application in the crisis time 2009–2011.

  11. Microelectronics from fundamentals to applied design

    CERN Document Server

    Di Paolo Emilio, Maurizio

    2016-01-01

    This book serves as a practical guide for practicing engineers who need to design analog circuits for microelectronics.  Readers will develop a comprehensive understanding of the basic techniques of analog modern electronic circuit design, discrete and integrated, application as sensors and control and data acquisition systems,and techniques of PCB design.  ·         Describes fundamentals of microelectronics design in an accessible manner; ·         Takes a problem-solving approach to the topic, offering a hands-on guide for practicing engineers; ·         Provides realistic examples to inspire a thorough understanding of system-level issues, before going into the detail of components and devices; ·         Uses a new approach and provides several skills that help engineers and designers retain key and advanced concepts.

  12. Semiconductor-inspired design principles for superconducting quantum computing.

    Science.gov (United States)

    Shim, Yun-Pil; Tahan, Charles

    2016-01-01

    Superconducting circuits offer tremendous design flexibility in the quantum regime culminating most recently in the demonstration of few qubit systems supposedly approaching the threshold for fault-tolerant quantum information processing. Competition in the solid-state comes from semiconductor qubits, where nature has bestowed some very useful properties which can be utilized for spin qubit-based quantum computing. Here we begin to explore how selective design principles deduced from spin-based systems could be used to advance superconducting qubit science. We take an initial step along this path proposing an encoded qubit approach realizable with state-of-the-art tunable Josephson junction qubits. Our results show that this design philosophy holds promise, enables microwave-free control, and offers a pathway to future qubit designs with new capabilities such as with higher fidelity or, perhaps, operation at higher temperature. The approach is also especially suited to qubits on the basis of variable super-semi junctions. PMID:26983379

  13. Semiconductor-inspired design principles for superconducting quantum computing

    Science.gov (United States)

    Shim, Yun-Pil; Tahan, Charles

    2016-01-01

    Superconducting circuits offer tremendous design flexibility in the quantum regime culminating most recently in the demonstration of few qubit systems supposedly approaching the threshold for fault-tolerant quantum information processing. Competition in the solid-state comes from semiconductor qubits, where nature has bestowed some very useful properties which can be utilized for spin qubit-based quantum computing. Here we begin to explore how selective design principles deduced from spin-based systems could be used to advance superconducting qubit science. We take an initial step along this path proposing an encoded qubit approach realizable with state-of-the-art tunable Josephson junction qubits. Our results show that this design philosophy holds promise, enables microwave-free control, and offers a pathway to future qubit designs with new capabilities such as with higher fidelity or, perhaps, operation at higher temperature. The approach is also especially suited to qubits on the basis of variable super-semi junctions. PMID:26983379

  14. Semiconductor-inspired design principles for superconducting quantum computing.

    Science.gov (United States)

    Shim, Yun-Pil; Tahan, Charles

    2016-03-17

    Superconducting circuits offer tremendous design flexibility in the quantum regime culminating most recently in the demonstration of few qubit systems supposedly approaching the threshold for fault-tolerant quantum information processing. Competition in the solid-state comes from semiconductor qubits, where nature has bestowed some very useful properties which can be utilized for spin qubit-based quantum computing. Here we begin to explore how selective design principles deduced from spin-based systems could be used to advance superconducting qubit science. We take an initial step along this path proposing an encoded qubit approach realizable with state-of-the-art tunable Josephson junction qubits. Our results show that this design philosophy holds promise, enables microwave-free control, and offers a pathway to future qubit designs with new capabilities such as with higher fidelity or, perhaps, operation at higher temperature. The approach is also especially suited to qubits on the basis of variable super-semi junctions.

  15. Principle of bio-inspired insect wing rotational hinge design

    Science.gov (United States)

    Fei, Fan

    A principle for designing and fabricating bio-inspired miniature artificial insect flapping wing using flexure rotational hinge design is presented. A systematic approach of selecting rotational hinge stiffness value is proposed. Based on the understanding of flapping wing aerodynamics, a dynamic simulation is constructed using the established quasi-steady model and the wing design. Simulations were performed to gain insight on how different parameters affect the wing rotational response. Based on system resonance a model to predict the optimal rotational hinge stiffness based on given wing parameter and flapping wing kinematic is proposed. By varying different wing parameters, the proposed method is shown to be applicable to a wide range of wing designs with different sizes and shapes. With the selected hinge stiffness value, aspects of the rotational joint design is discussed and an integrated wing-hinge structure design using laminated carbon fiber and polymer film is presented. Manufacturing process of such composite structure is developed to achieve high accuracy and repeatability. The yielded hinge stiffness is verified by measurements. To validate the proposed model, flapping wing experiments were conducted. A flapping actuation set up is built using DC motor and a controller is implemented on a microcontroller to track desired wing stroke kinematic. Wing stroke and rotation kinematic were extracted using a high speed camera and the lift generation is evaluated. A total of 49 flapping experiments were presented, experimental data shows good correlation with the model's prediction. With the wing rotational hinge stiffness designed so that the rotational resonant frequency is twice as the stroke frequency, the resulting wing rotation generates near optimal lift. With further simulation, the proposed model shows low sensitivity to wing parameter variation. As a result, giving a design parameter of a flapping wing robot platform, the proposed principle can

  16. Bayesian Design Space applied to Pharmaceutical Development

    OpenAIRE

    Lebrun, Pierre

    2012-01-01

    Given the guidelines such as the Q8 document published by the International Conference on Harmonization (ICH), that describe the “Quality by Design” paradigm for the Pharmaceutical Development, the aim of this work is to provide a complete methodology addressing this problematic. As a result, various Design Spaces were obtained for different analytical methods and a manufacturing process. In Q8, Design Space has been defined as the “the multidimensional combination and interaction of input...

  17. Engineering emergence: applied theory for game design

    OpenAIRE

    Dormans, J.

    2012-01-01

    Dit proefschrift presenteert twee theoretische kaders voor het ontwerpen van games en beschrijft hoe game designers deze kunnen inzetten om het game ontwerpproces te stroomlijnen. Er bestaan op dit moment meerdere ontwerptheorie¨en voor games, maar geen enkele kan rekenen op een breed draagvlak binnen de game industrie. Vooral academische ontwerptheorie¨en hebben regelmatig een slechte reputatie. Het eerste kader dat game designers inzicht biedt in spelregels en hun werking heet Machinations ...

  18. Design principles of the human brain: an evolutionary perspective.

    Science.gov (United States)

    Hofman, Michel A

    2012-01-01

    The evolution of the brain in mammals has been accompanied by a reorganization of the brain as a result of differential growth of certain brain regions. Consequently, the geometry of the brain, and especially the size and shape of the cerebral cortex, has changed notably during evolution. Comparative studies of the cerebral cortex suggest that there are general architectural principles governing its growth and evolutionary development and that the primate neocortex is uniformly organized and composed of neural processing units. We are beginning to understand the geometric, biophysical, and energy constraints that have governed the evolution of these neuronal networks. In this review, some of the design principles and operational modes will be explored that underlie the information processing capacity of the cerebral cortex in primates, and it will be argued that with the evolution of the human brain we have nearly reached the limits of biological intelligence.

  19. Designing for Open Learning: Design Principles and Scalability Affordances in Practice

    OpenAIRE

    Firssova, Olga; Brouns, Francis; Kalz, Marco

    2016-01-01

    This work-in-progress paper elaborates on a gradually evolving approach to design of open learning and the design principles used by the Open University of the Netherlands in short open courses - online masterclasses and in Massive Open Online Courses – delivered in the learning environment of the Open University and in the experimental multilingual MOOC aggregator EMMA as part of a European project. As the paper will demonstrate, these principles can be seen as building blocks of open scalab...

  20. Design Principles for Serious Video Games in Mathematics Education: From Theory to Practice

    Directory of Open Access Journals (Sweden)

    Konstantinos Chorianopoulos

    2014-09-01

    Full Text Available There is growing interest in the employment of serious video games in science education, but there are no clear design principles. After surveying previous work in serious video game design, we highlighted the following design principles: 1 engage the students with narrative (hero, story, 2 employ familiar gameplay mechanics from popular video games, 3 engage students into constructive trial and error game-play and 4 situate collaborative learning. As illustrated examples we designed two math video games targeted to primary education students. The gameplay of the math video games embeds addition operations in a seamless way, which has been inspired by that of classic platform games. In this way, the students are adding numbers as part of popular gameplay mechanics and as a means to reach the video game objective, rather than as an end in itself. The employment of well-defined principles in the design of math video games should facilitate the evaluation of learning effectiveness by researchers. Moreover, educators can deploy alternative versions of the games in order to engage students with diverse learning styles. For example, some students might be motived and benefited by narrative, while others by collaboration, because it is unlikely that one type of serious video game might fit all learning styles. The proposed principles are not meant to be an exhaustive list, but a starting point for extending the list and applying them in other cases of serious video games beyond mathematics and learning.

  1. In search of design principles for developing digital learning & performance support for a student design task

    NARCIS (Netherlands)

    Bollen, Lars; Van der Meij, Hans; Leemkuil, Henny; McKenney, Susan

    2016-01-01

    A digital learning and performance support environment for university student design tasks was developed. This paper describes on the design rationale, process, and the usage results to arrive at a core set of design principles for the construction of such an environment. We present a collection of

  2. In search of design principles for developing digital learning & performance support for a student design task

    NARCIS (Netherlands)

    Bollen, Lars; Meij, van der Hans; Leemkuil, Henny; McKenney, Susan

    2015-01-01

    A digital learning and performance support environment for university student design tasks was developed. This paper describes on the design rationale, process, and the usage results to arrive at a core set of design principles for the construction of such an environment. We present a collection of

  3. Integrating rock mechanics issues with repository design through design process principles and methodology

    Energy Technology Data Exchange (ETDEWEB)

    Bieniawski, Z.T. [Pennsylvania State Univ., University Park, PA (United States)

    1996-04-01

    A good designer needs not only knowledge for designing (technical know-how that is used to generate alternative design solutions) but also must have knowledge about designing (appropriate principles and systematic methodology to follow). Concepts such as {open_quotes}design for manufacture{close_quotes} or {open_quotes}concurrent engineering{close_quotes} are widely used in the industry. In the field of rock engineering, only limited attention has been paid to the design process because design of structures in rock masses presents unique challenges to the designers as a result of the uncertainties inherent in characterization of geologic media. However, a stage has now been reached where we are be able to sufficiently characterize rock masses for engineering purposes and identify the rock mechanics issues involved but are still lacking engineering design principles and methodology to maximize our design performance. This paper discusses the principles and methodology of the engineering design process directed to integrating site characterization activities with design, construction and performance of an underground repository. Using the latest information from the Yucca Mountain Project on geology, rock mechanics and starter tunnel design, the current lack of integration is pointed out and it is shown how rock mechanics issues can be effectively interwoven with repository design through a systematic design process methodology leading to improved repository performance. In essence, the design process is seen as the use of design principles within an integrating design methodology, leading to innovative problem solving. In particular, a new concept of {open_quotes}Design for Constructibility and Performance{close_quotes} is introduced. This is discussed with respect to ten rock mechanics issues identified for repository design and performance.

  4. Integrating rock mechanics issues with repository design through design process principles and methodology

    International Nuclear Information System (INIS)

    A good designer needs not only knowledge for designing (technical know-how that is used to generate alternative design solutions) but also must have knowledge about designing (appropriate principles and systematic methodology to follow). Concepts such as open-quotes design for manufactureclose quotes or open-quotes concurrent engineeringclose quotes are widely used in the industry. In the field of rock engineering, only limited attention has been paid to the design process because design of structures in rock masses presents unique challenges to the designers as a result of the uncertainties inherent in characterization of geologic media. However, a stage has now been reached where we are be able to sufficiently characterize rock masses for engineering purposes and identify the rock mechanics issues involved but are still lacking engineering design principles and methodology to maximize our design performance. This paper discusses the principles and methodology of the engineering design process directed to integrating site characterization activities with design, construction and performance of an underground repository. Using the latest information from the Yucca Mountain Project on geology, rock mechanics and starter tunnel design, the current lack of integration is pointed out and it is shown how rock mechanics issues can be effectively interwoven with repository design through a systematic design process methodology leading to improved repository performance. In essence, the design process is seen as the use of design principles within an integrating design methodology, leading to innovative problem solving. In particular, a new concept of open-quotes Design for Constructibility and Performanceclose quotes is introduced. This is discussed with respect to ten rock mechanics issues identified for repository design and performance

  5. Proof of principle for epitope-focused vaccine design

    Science.gov (United States)

    Correia, Bruno E.; Bates, John T.; Loomis, Rebecca J.; Baneyx, Gretchen; Carrico, Chris; Jardine, Joseph G.; Rupert, Peter; Correnti, Colin; Kalyuzhniy, Oleksandr; Vittal, Vinayak; Connell, Mary J.; Stevens, Eric; Schroeter, Alexandria; Chen, Man; MacPherson, Skye; Serra, Andreia M.; Adachi, Yumiko; Holmes, Margaret A.; Li, Yuxing; Klevit, Rachel E.; Graham, Barney S.; Wyatt, Richard T.; Baker, David; Strong, Roland K.; Crowe, James E.; Johnson, Philip R.; Schief, William R.

    2014-03-01

    Vaccines prevent infectious disease largely by inducing protective neutralizing antibodies against vulnerable epitopes. Several major pathogens have resisted traditional vaccine development, although vulnerable epitopes targeted by neutralizing antibodies have been identified for several such cases. Hence, new vaccine design methods to induce epitope-specific neutralizing antibodies are needed. Here we show, with a neutralization epitope from respiratory syncytial virus, that computational protein design can generate small, thermally and conformationally stable protein scaffolds that accurately mimic the viral epitope structure and induce potent neutralizing antibodies. These scaffolds represent promising leads for the research and development of a human respiratory syncytial virus vaccine needed to protect infants, young children and the elderly. More generally, the results provide proof of principle for epitope-focused and scaffold-based vaccine design, and encourage the evaluation and further development of these strategies for a variety of other vaccine targets, including antigenically highly variable pathogens such as human immunodeficiency virus and influenza.

  6. Application of Instructional Design Principles in Developing an Online Information Literacy Curriculum.

    Science.gov (United States)

    Mi, Misa

    2016-01-01

    An online information literacy curriculum was developed as an intervention to engage students in independent study and self-assessment of their learning needs and learning outcomes, develop proficiency in information skills, and foster lifelong learning. This column demonstrates how instructional design principles were applied to create the learning experiences integrated into various courses of the medical curriculum to promote active learning of information skills and maximize self-directed learning outcomes for lifelong learning.

  7. Applying Universal Design for Learning to Instructional Lesson Planning

    Science.gov (United States)

    McGhie-Richmond, Donna; Sung, Andrew N.

    2013-01-01

    Universal Design for Learning is a framework for developing inclusive instructional lesson plans. The effects of introducing Universal Design for Learning Principles and Guidelines in a university teacher education program with pre-service and practicing teachers were explored in a mixed methods approach. The results indicate that the study…

  8. Maximum Principle for Linear-Convex Boundary Control Problems applied to Optimal Investment with Vintage Capital

    CERN Document Server

    Faggian, Silvia

    2007-01-01

    The paper concerns the study of the Pontryagin Maximum Principle for an infinite dimensional and infinite horizon boundary control problem for linear partial differential equations. The optimal control model has already been studied both in finite and infinite horizon with Dynamic Programming methods in a series of papers by the same author, or by Faggian and Gozzi. Necessary and sufficient optimality conditions for open loop controls are established. Moreover the co-state variable is shown to coincide with the spatial gradient of the value function evaluated along the trajectory of the system, creating a parallel between Maximum Principle and Dynamic Programming. The abstract model applies, as recalled in one of the first sections, to optimal investment with vintage capital.

  9. SYSTEMATIC PRINCIPLES AND METHODS OF SYMBOLIC APPROACHES IN URBAN DESIGN

    Directory of Open Access Journals (Sweden)

    BULAKH I. V

    2015-12-01

    Full Text Available Formulation of the problem. The low level of expression and personalization of mass architecture of the second half of the twentieth century connected with the spread of industrial technology and even to a greater extent with mechanistic traditionally functional relation to the average person as, abstract consumer architecture. The condition out of the critical situation is focusing on matters aesthetic, artistic understanding and harmonious image creation environment. The problem of increasing architectural and artistic level of architectural and urban planning solutions to overcome the monotony of planning and development, creating aesthetically expressive urban environment does not lose relevance over the past decades. Understanding and acceptance of enigma and dynamic development of cities encourage architects to find new design techniques that are able to provide in the future a reasonable possibility of forming artistic and aesthetic image of the modern city. Purpose. Define and systematize the principles of symbolization architectural and planning images; propose methods symbolism in the architectural planning of image of the urban environment. Conclusion based on analysis of the enhanced concept symbolizing the image of Architecture and Planning, the place, role and symbolization trends at all levels of the urban environment - planning, three-dimensional and improvement of urban areas; first identified the main stages and levels of symbolization (analohyzatsyya, schematization and alehoryzatsiya, their features and characteristics, formulated the basic principles of symbolization architectural and planning of image, namely the principles of communication between figurative analogies, transformation of subsequent circuits, switching allegorical groupings and metamorfizm ultimate goal – symbol birth .

  10. Design principles and algorithms for automated air traffic management

    Science.gov (United States)

    Erzberger, Heinz

    1995-01-01

    This paper presents design principles and algorithm for building a real time scheduler. The primary objective of the scheduler is to assign arrival aircraft to a favorable landing runway and schedule them to land at times that minimize delays. A further objective of the scheduler is to allocate delays between high altitude airspace far from the airport and low altitude airspace near the airport. A method of delay allocation is described that minimizes the average operating cost in the presence of errors in controlling aircraft to a specified landing time.

  11. Engineering emergence: applied theory for game design

    OpenAIRE

    Scha, R.J.H.; Brunekreef, J.J.; Dormans, J.

    2012-01-01

    Joris Dormans ontwikkelde softwaretools om het ontwerpen van games te ondersteunen en naar een hoger plan te tillen. Toegepaste theorie voor game design, zoals Dormans die voorstelt, is er op gericht om creativiteit te ondersteunen, het ontwerpproces te versnellen, en de kwaliteit van games te verhogen. Hierbij spelen twee theoretische kaders een rol. Het eerste kader beschrijft games als systemen van spelregels, waarbij de onderlinge structuur van doorslaggevend belang is in het onvoorspelba...

  12. Five Principles for MOOC Design: With a Case Study

    Directory of Open Access Journals (Sweden)

    John R. Drake

    2015-05-01

    Full Text Available New web technologies have enabled online education to take on a massive scale, prompting many universities to create massively open online courses (MOOCs that take advantage of these technologies in a seemingly effortless manner. Designing a MOOC, however, is anything but trivial. It involves developing content, learning activities, and assessments to accommodate both the massiveness and openness of the course. To design an effective MOOC, instructors need to integrate both pedagogical and information systems theory. In this paper, we present a case study of a MOOC grant and a series of decisions made in its development. These decisions, when paired with the theoretical framework, suggest five principles – meaningful, engaging, measurable, accessible, and scalable – may be applicable to future MOOC development projects.

  13. IFE Power Plant design principles. Drivers. Solid state laser drivers

    International Nuclear Information System (INIS)

    The present status of solid state laser drivers for an inertial confinement thermonuclear fusion power plant is discussed. In particular, the feasibility of laser diode pumped solid state laser drivers from both the technical and economic points of view is briefly reviewed. Conceptual design studies showed that they can, in principle, satisfy the design requirements. However, development of new solid state materials with long fluorescence lifetimes and good thermal characteristics is a key issue for laser diode pumped solid state lasers. With the advent of laser diode pumping many materials which were abandoned in the past can presently be reconsidered as viable candidates. It is also concluded that it is important to examine the technical requirements for solid state lasers in relation to target performance criteria. The progress of laser diode pumped lasers in industrial applications should also be closely watched to provide additional information on the economic feasibility of this type of driver. 15 refs, 9 figs, 2 tabs

  14. First Principles Design of Non-Centrosymmetric Metal Oxides

    Science.gov (United States)

    Young, Joshua Aaron

    The lack of an inversion center in a material's crystal structure can result in many useful material properties, such as ferroelectricity, piezoelectricity and non-linear optical behavior. Recently, the desire for low power, high efficiency electronic devices has spurred increased interest in these phenomena, especially ferroelectricity, as well as their coupling to other material properties. By studying and understanding the fundamental structure-property relationships present in non-centrosymmetric materials, it is possible to purposefully engineer new compounds with the desired "acentric" qualities through crystal engineering. The families of ABO3 perovskite and ABO2.5 perovskite-derived brownmillerite oxides are ideal for such studies due to their wide range of possible chemistries, as well as ground states that are highly tunable owing to strong electron-lattice coupling. Furthermore, control over the B-O-B bond angles through epitaxial strain or chemical substitution allows for the rapid development of new emergent properties. In this dissertation, I formulate the crystal-chemistry criteria necessary to design functional non-centrosymmetric oxides using first-principles density functional theory calculations. Recently, chemically ordered (AA')B2O 6 oxides have been shown to display a new form of rotation-induced ferroelectric polarizations. I now extend this property-design methodology to alternative compositions and crystal classes and show it is possible to induce a host of new phenomena. This dissertation will address: 1) the formulation of predictive models allowing for a priori design of polar oxides, 2) the optimization of properties exhibited by these materials through chemical substitution and cation ordering, and 3) the use of strain to control the stability of new phases. Completion of this work has led to a deeper understanding of how atomic structural features determine the physical properties of oxides, as well as the successful elucidation of

  15. Bernoulli's Principle Applied to Brain Fluids: Intracranial Pressure Does Not Drive Cerebral Perfusion or CSF Flow.

    Science.gov (United States)

    Schmidt, Eric; Ros, Maxime; Moyse, Emmanuel; Lorthois, Sylvie; Swider, Pascal

    2016-01-01

    In line with the first law of thermodynamics, Bernoulli's principle states that the total energy in a fluid is the same at all points. We applied Bernoulli's principle to understand the relationship between intracranial pressure (ICP) and intracranial fluids. We analyzed simple fluid physics along a tube to describe the interplay between pressure and velocity. Bernoulli's equation demonstrates that a fluid does not flow along a gradient of pressure or velocity; a fluid flows along a gradient of energy from a high-energy region to a low-energy region. A fluid can even flow against a pressure gradient or a velocity gradient. Pressure and velocity represent part of the total energy. Cerebral blood perfusion is not driven by pressure but by energy: the blood flows from high-energy to lower-energy regions. Hydrocephalus is related to increased cerebrospinal fluid (CSF) resistance (i.e., energy transfer) at various points. Identification of the energy transfer within the CSF circuit is important in understanding and treating CSF-related disorders. Bernoulli's principle is not an abstract concept far from clinical practice. We should be aware that pressure is easy to measure, but it does not induce resumption of fluid flow. Even at the bedside, energy is the key to understanding ICP and fluid dynamics. PMID:27165887

  16. General principles and stages of optimal AFCS design

    Science.gov (United States)

    Platonov, A.; Zaitsev, Ie.

    2014-11-01

    The goal of the paper is a discussion of general principle and stages of the optimal analog feedback communication systems (AFCS) design. Previous research devoted to the analysis of particularities of AFCS functioning gave necessary analytical basis for transition to practical design of optimal AFCS. This is new class of communication systems (CS) transmitting the signals, under given bit error rate (BER), with bit rate equal to the capacity of the forward channel and power-bandwidth efficiency attaining the theoretical limit. In the paper, we describe the ordered sequence of the stages of transition from the abstract results to designing of the pre-commercial versions of optimal AFCS considering them as the basic communication link "sensor node (SN)" - "base station" (BS) of the wireless sensor network (WSN). We also show that verified theoretical results enable analytically argued decision making at different stages of designing of the high quality and energy efficient WSN communication links. This facilitates optimisation of the project works schedule, distribution of the tasks and resources for their realization, reduce the time and cost of design.

  17. Design Principles for Oxygen Reduction and Evolution on Oxide Catalysts

    Science.gov (United States)

    Shao-Horn, Yang

    2012-02-01

    Driven by growing concerns about global warming and the depletion of petroleum resources, developing renewable energy production and storage technologies represent one of the major scientific challenges of the 21^st century. A critical element in pursuit of this quest is the discovery of efficient and cost-effective catalysts used in solar fuel production via electrochemical energy conversion processes such as oxygen evolution reaction (OER) and oxygen reduction reaction (ORR), both of which are central to the efficiencies of direct-solar and electrolytic water-splitting devices, fuel cells, and metal-air batteries. Although the Sabatier's principle provides a qualitative argument in tuning catalytic activity by varying the bond strength between catalyst surface and reactant/product (neither too strong nor too weak leading to the maximum activity at moderate bond strength), it has no predictive power to find catalysts with enhanced activity. Identifying a ``design principle'' that links catalyst properties to the catalytic activity is critical to accelerate the search for highly active catalysts based on abundant elements, and minimize the use of precious metals. Here we establish a molecular principle that governs the activities of oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) for oxide catalysts, where the activities primarily correlate to the σ* orbital (``eg'') occupation of surface transition-metal cations established by systematic examination of more than ten to fifteen transition-metal oxides. The intrinsic ORR and OER activities exhibit a volcano-shaped dependence on the eg occupancy and the activities peak at an eg occupancy close to unity. Our findings reflect the critical influence of the σ* orbital on the energetics of surface reaction intermediates on surface transition metal ions such as the O2^2-/OH^- displacement and the OH^- regeneration, and thus highlight the importance of surface oxide electronic structure in controlling

  18. Productivity Improvement by Applying DILO (Time and Motion and Lean Principles

    Directory of Open Access Journals (Sweden)

    Mallikarjun Koripadu

    2014-10-01

    Full Text Available In recent years, service industries are struggling to improve their processes efficiencies. Lean principles and the methodologies are becoming a prime problem solving approaches to perform the operational processes with a minimum non-value adding activities resulting in reduced wait time, movements, defect rates and other delays in the process. This paper addresses the implementation of lean principles in a one of the service organizations. The main objective of this paper is to draw the As-Is process map, conduct process analysis to identify non-value added activities, capture the time using DILO (day in a life of…, simplify or eliminate the same and improve efficiency of the process. Through the application of lean principles the As-Is and To-Be process maps are constructed to improve the operational processes by identifying different waste and its sources of wastes. A noticeable reduction in processing time is observed in the process by simplifying and eliminating the non value added activities in the process. This case study can be useful in developing a more generic approach to design lean environment

  19. Synthetic RNAs for gene regulation: design principles and computational tools

    Directory of Open Access Journals (Sweden)

    Alessandro eLaganà

    2014-12-01

    Full Text Available The use of synthetic non-coding RNAs for post-transcriptional regulation of gene expression has not only become a standard laboratory tool for gene functional studies, but it has also opened up new perspectives in the design of new and potentially promising therapeutic strategies. Bioinformatics has provided researchers with a variety of tools for the design, the analysis and the evaluation of RNAi agents such as small-interfering RNA (siRNA, short-hairpin RNA (shRNA, artificial microRNA (a-miR and microRNA sponges. More recently, a new system for genome engineering based on the bacterial CRISPR-Cas9 system (Clustered Regularly Interspaced Short Palindromic Repeats, was shown to have the potential to also regulate gene expression at both transcriptional and post-transcriptional level in a more specific way. In this mini review, we present RNAi and CRISPRi design principles and discuss the advantages and limitations of the current design approaches.

  20. Coalescence vs. concatenation: Sophisticated analyses vs. first principles applied to rooting the angiosperms.

    Science.gov (United States)

    Simmons, Mark P; Gatesy, John

    2015-10-01

    It has recently been concluded that phylogenomic data from 310 nuclear genes support the clade of (Amborellales, Nymphaeales) as sister to the remaining angiosperms and that shortcut coalescent phylogenetic methods outperformed concatenation for these data. We falsify both of those conclusions here by demonstrating that discrepant results between the coalescent and concatenation analyses are primarily caused by the coalescent methods applied (MP-EST and STAR) not being robust to the highly divergent and often mis-rooted gene trees that were used. This result reinforces the expectation that low amounts of phylogenetic signal and methodological artifacts in gene-tree reconstruction can be more problematic for shortcut coalescent methods than is the assumption of a single hierarchy for all genes by concatenation methods when these approaches are applied to ancient divergences in empirical studies. We also demonstrate that a third coalescent method, ASTRAL, is more robust to mis-rooted gene trees than MP-EST or STAR, and that both Observed Variability (OV) and Tree Independent Generation of Evolutionary Rates (TIGER), which are two character subsampling procedures, are biased in favor of characters with highly asymmetrical distributions of character states when applied to this dataset. We conclude that enthusiastic application of novel tools is not a substitute for rigorous application of first principles, and that trending methods (e.g., shortcut coalescent methods applied to ancient divergences, tree-independent character subsampling), may be novel sources of previously under-appreciated, systematic errors. PMID:26002829

  1. Parallel power electronics filters in three-phase four-wire systems principle, control and design

    CERN Document Server

    Wong, Man-Chung; Lam, Chi-Seng

    2016-01-01

    This book describes parallel power electronic filters for 3-phase 4-wire systems, focusing on the control, design and system operation. It presents the basics of power-electronics techniques applied in power systems as well as the advanced techniques in controlling, implementing and designing parallel power electronics converters. The power-quality compensation has been achieved using active filters and hybrid filters, and circuit models, control principles and operational practice problems have been verified by principle study, simulation and experimental results. The state-of-the-art research findings were mainly developed by a team at the University of Macau. Offering background information and related novel techniques, this book is a valuable resource for electrical engineers and researchers wanting to work on energy saving using power-quality compensators or renewable energy power electronics systems. .

  2. Applying persuasive design in a diabetes mellitus application

    NARCIS (Netherlands)

    Smink, Sjoerd

    2012-01-01

    This paper describes persuasive design methods and compares this to an application currently under development for diabetes mellitus patients. Various elements of persuasion and a categorization of persuasion types are mentioned. Also discussed are principles of how successful persuasion should be d

  3. Carbon-rich icosahedral boron carbide designed from first principles

    Energy Technology Data Exchange (ETDEWEB)

    Jay, Antoine; Vast, Nathalie; Sjakste, Jelena; Duparc, Olivier Hardouin [Ecole Polytechnique, Laboratoire des Solides Irradiés, CEA-DSM-IRAMIS, CNRS UMR 7642, F-91120 Palaiseau (France)

    2014-07-21

    The carbon-rich boron-carbide (B{sub 11}C)C-C has been designed from first principles within the density functional theory. With respect to the most common boron carbide at 20% carbon concentration B{sub 4}C, the structural modification consists in removing boron atoms from the chains linking (B{sub 11}C) icosahedra. With C-C instead of C-B-C chains, the formation of vacancies is shown to be hindered, leading to enhanced mechanical strength with respect to B{sub 4}C. The phonon frequencies and elastic constants turn out to prove the stability of the carbon-rich phase, and important fingerprints for its characterization have been identified.

  4. Usability principles to design mobile workplace learning content

    Directory of Open Access Journals (Sweden)

    Alessia Messuti

    2015-04-01

    Full Text Available The article describes the design of a mobile workplace learning tool for trainers of the International Training Centre of the International Labour Organization. The motivation behind is to provide trainers with a practical tool that will enable them to recall information at the moment of need and continue to learn in context. On this purpose a set of visual augmented reality cards was created, taking into consideration the fundamental mobile learning and usability principles. The nature of the article is empirical as it reports an experiment carried out with trainers which aimed at testing cards usability and learnability. Results show that the integration of both online and offline strategies was perceived as an added value as trainers could choose to retrieve information as they mostly like; finally, it also resulted in high usability scores, an aspect that contributes to their effectiveness at the workplace.

  5. Using the principles of circadian physiology enhances shift schedule design

    Energy Technology Data Exchange (ETDEWEB)

    Connolly, J.J.; Moore-Ede, M.C.

    1987-01-01

    Nuclear power plants must operate 24 h, 7 days a week. For the most part, shift schedules currently in use at nuclear power plants have been designed to meet operational needs without considering the biological clocks of the human operators. The development of schedules that also take circadian principles into account is a positive step that can be taken to improve plant safety by optimizing operator alertness. These schedules reduce the probability of human errors especially during backshifts. In addition, training programs that teach round-the-clock workers how to deal with the problems of shiftwork can help to optimize performance and alertness. These programs teach shiftworkers the underlying causes of the sleep problems associated with shiftwork and also provide coping strategies for improving sleep and dealing with the transition between shifts. When these training programs are coupled with an improved schedule, the problems associated with working round-the-clock can be significantly reduced.

  6. Temporal Evolution of Design Principles in Engineering Systems: Analogies with Human Evolution

    DEFF Research Database (Denmark)

    Deb, Kalyanmoy; Bandaru, Sunith; Tutum, Cem Celal

    2012-01-01

    constructed later during optimization. Interestingly, there exists a simile between evolution of design principles with that of human evolution. Such information about the hierarchy of key design principles should enable designers to have a deeper understanding of their problems....... among near-Paretooptimal solutions, the main crux of this paper lies in a demonstration of temporal evolution of these principles during the course of optimization. The results reveal that certain important design principles start to evolve early on, whereas some detailed design principles get...

  7. Does the principle of minimum work apply at the carotid bifurcation: a retrospective cohort study

    International Nuclear Information System (INIS)

    There is recent interest in the role of carotid bifurcation anatomy, geometry and hemodynamic factors in the pathogenesis of carotid artery atherosclerosis. Certain anatomical and geometric configurations at the carotid bifurcation have been linked to disturbed flow. It has been proposed that vascular dimensions are selected to minimize energy required to maintain blood flow, and that this occurs when an exponent of 3 relates the radii of parent and daughter arteries. We evaluate whether the dimensions of bifurcation of the extracranial carotid artery follow this principle of minimum work. This study involved subjects who had computed tomographic angiography (CTA) at our institution between 2006 and 2007. Radii of the common, internal and external carotid arteries were determined. The exponent was determined for individual bifurcations using numerical methods and for the sample using nonlinear regression. Mean age for 45 participants was 56.9 ± 16.5 years with 26 males. Prevalence of vascular risk factors was: hypertension-48%, smoking-23%, diabetes-16.7%, hyperlipidemia-51%, ischemic heart disease-18.7%. The value of the exponent ranged from 1.3 to 1.6, depending on estimation methodology. The principle of minimum work (defined by an exponent of 3) may not apply at the carotid bifurcation. Additional factors may play a role in the relationship between the radii of the parent and daughter vessels

  8. IN QUEST OF TOTAL QUALITY MANAGEMENT PRINCIPLES IN ARCHITECTURAL DESIGN SERVICES: EVIDENCE FROM TURKEY

    Directory of Open Access Journals (Sweden)

    Umut Durmus

    2010-12-01

    Full Text Available Proposal: Architectural design companies increasingly recognize that time spent on management is not at the expense of their production and there are always better ways to organize business. Although architects have long placed a traditional emphasis on quality, quality management is still a new concept for the majority of architectural design companies, which have to organize relatively more complicated operations nowadays to meet their clients’ expectations. This study aims to understand how architectural design companies define quality and explores the extent to which Total Quality Management (TQM principles like continual improvement, employee involvement, customer satisfaction and others can be pertinent in these companies. Adopting a qualitative research strategy, the authors interviewed with the owner-managers of 10 widely-recognized architectural design companies of different size in Istanbul. The results from the content analysis of semi-structured interview data suggest that i TQM principles cannot be directly applied in architectural design companies without an appropriate translation; ii special characteristics of design services are important to explain quality-related perceptions of owner-managers; iii the owner-managers feel the pressure from the changing internal and external environmental conditions, however few of them adopt a systematic and documented approach to quality management. Architectural design offices which aim to establish a quality management system can benefit from this study to understand potential problem areas on their road.

  9. A practical guide to applying lean tools and management principles to health care improvement projects.

    Science.gov (United States)

    Simon, Ross W; Canacari, Elena G

    2012-01-01

    Manufacturing organizations have used Lean management principles for years to help eliminate waste, streamline processes, and cut costs. This pragmatic approach to structured problem solving can be applied to health care process improvement projects. Health care leaders can use a step-by-step approach to document processes and then identify problems and opportunities for improvement using a value stream process map. Leaders can help a team identify problems and root causes and consider additional problems associated with methods, materials, manpower, machinery, and the environment by using a cause-and-effect diagram. The team then can organize the problems identified into logical groups and prioritize the groups by impact and difficulty. Leaders must manage action items carefully to instill a sense of accountability in those tasked to complete the work. Finally, the team leaders must ensure that a plan is in place to hold the gains.

  10. Applying object technology principles to business reengineering in the oil, gas, and petrochemical industries

    International Nuclear Information System (INIS)

    The oil, gas, and petrochemical industries face a dilemma, to be financially competitive while complying with strict and expanding environmental, safety, and health regulation. Companies need new tools and techniques, indeed a completely new paradigm for organizing and performing work. They must build efficient and flexible business processes, ones that rely on advanced information systems for improved decision making and productivity. And they must adopt a culture of change and improvement to permit the business to change as the business climate changes. Fortunately, two industry developments are changing the traditional business paradigm in a dramatic way; business reengineering and object technology. Applying principles of object technology in the performance of business reengineering makes available a new form of business modeling that transforms the technique of modeling a business while directly supported the development of its enabling information systems. This modeling technique is called Object Modeling and is becoming an important force in improving business competitiveness

  11. Non-Flutter Design Principle for long Span Bridges

    DEFF Research Database (Denmark)

    Johansson, Jens; Andersen, Michael Styrk; Starch Øvre, Michele

    The case of flutter on a sharp edged flat plate section model, with a height-to-width ratio of 1:10, has been investigated at four different torsional-to-vertical frequency ratios equal to 0.71, 0.88, 1.19 and 2.10. At a torsional-to-vertical frequency ratio of approximately 1.1 the flutter wind...... velocity for a thin airfoil shows an asymptotical behavior. In traditional bridge design the torsional-to-vertical frequency ratio is increased to obtain higher flutter wind velocities. In the present study, we investigate, what we will label the non-flutter design principle, in which the torsional......-to-vertical frequency ratio will deliberately be smaller than 1. Two cases with frequency ratios of 1.19 and 2.10 showed classical and torsional flutter, respectively. Within the maximum wind velocity obtainable in the wind tunnel the two cases with a frequency ratio below 1 did not show any sign of aerodynamic...

  12. Conceptual design principles for the MHD-induction generator

    International Nuclear Information System (INIS)

    Conceptual design of the MHD-Induction generator using the exhaust plasma from the fusion reactor divertor as the working fluid and the principles of induction by transformer action is considered in this work. Exciting magnetic field is provided by a set of multi-conductors sheet carrying time varying sinusoidal current. Spacing of line conductors is discrete and arranged such that alternation of boundary layer separation will occur at the generator channel wall, provided the magnetic Reynolds number will exceed 10% as had been already established in published carried out by the 2nd, author. An output three phase conventional winding will carry the induced output voltage by transformer action. Solutions of the induced field identified as odd triangular time varying waves are expanded through Fourier Theorm into its fundamental and a large set of odd harmonics. For the ultimate aim of securing pure sinusoidal output, detailed conceptual design for the conventional winding is carried out, especially for an optimum winding pitch factor. Selection of winding pitch factor of 83.5% resulted in significant reduction in the 5th, the 7th and the eleventh harmonics by 1%, 0.5% and 0.04% of the fundamental strength. Solutions are obtained up to the 65th harmonic to ensure reliable information regarding minimization of their strength

  13. Silver Nanoclusters: From Design Principles to Practical Applications

    KAUST Repository

    Abdulhalim, Lina G.

    2015-12-08

    A strategy based on reticulating metal ions and organic ligands into atomically precise gold and silver nanoclusters (NCs) with high monodispersity has been advanced to a point that allows the design of NCs with strict stoichiometries, functionalities and valence. Of the Ag NCs discovered, Ag44 is the most studied, not only due to its high absorption that transcends the visible spectrum suitable for photovoltaics but also because of its long excited state lifetime, as revealed by nanosecond transient absorption spectroscopy. A major principle discovered in this dissertation is the ability to produce Ag44 in scalable amounts and with high stability in addition to modulation of the functional groups of the organic ligands via a fast and complete ligand exchange process. This new discovery has led to the development of synthetic designs in which new sizes were obtained by varying the reaction parameters (e.g., ligands functionality, reaction temperature and time), namely, Ag29 using dithiols and phosphines. The synthesized NCs possess tetravalent functionalities that facilitate their crystallization and characterization. Furthermore, Ag29 glows red and is therefore a possible candidate for sensing and imaging applications.

  14. Design principles for engaging and retaining virtual citizen scientists.

    Science.gov (United States)

    Wald, Dara M; Longo, Justin; Dobell, A R

    2016-06-01

    Citizen science initiatives encourage volunteer participants to collect and interpret data and contribute to formal scientific projects. The growth of virtual citizen science (VCS), facilitated through websites and mobile applications since the mid-2000s, has been driven by a combination of software innovations and mobile technologies, growing scientific data flows without commensurate increases in resources to handle them, and the desire of internet-connected participants to contribute to collective outputs. However, the increasing availability of internet-based activities requires individual VCS projects to compete for the attention of volunteers and promote their long-term retention. We examined program and platform design principles that might allow VCS initiatives to compete more effectively for volunteers, increase productivity of project participants, and retain contributors over time. We surveyed key personnel engaged in managing a sample of VCS projects to identify the principles and practices they pursued for these purposes and led a team in a heuristic evaluation of volunteer engagement, website or application usability, and participant retention. We received 40 completed survey responses (33% response rate) and completed a heuristic evaluation of 20 VCS program sites. The majority of the VCS programs focused on scientific outcomes, whereas the educational and social benefits of program participation, variables that are consistently ranked as important for volunteer engagement and retention, were incidental. Evaluators indicated usability, across most of the VCS program sites, was higher and less variable than the ratings for participant engagement and retention. In the context of growing competition for the attention of internet volunteers, increased attention to the motivations of virtual citizen scientists may help VCS programs sustain the necessary engagement and retention of their volunteers.

  15. Design principles for engaging and retaining virtual citizen scientists.

    Science.gov (United States)

    Wald, Dara M; Longo, Justin; Dobell, A R

    2016-06-01

    Citizen science initiatives encourage volunteer participants to collect and interpret data and contribute to formal scientific projects. The growth of virtual citizen science (VCS), facilitated through websites and mobile applications since the mid-2000s, has been driven by a combination of software innovations and mobile technologies, growing scientific data flows without commensurate increases in resources to handle them, and the desire of internet-connected participants to contribute to collective outputs. However, the increasing availability of internet-based activities requires individual VCS projects to compete for the attention of volunteers and promote their long-term retention. We examined program and platform design principles that might allow VCS initiatives to compete more effectively for volunteers, increase productivity of project participants, and retain contributors over time. We surveyed key personnel engaged in managing a sample of VCS projects to identify the principles and practices they pursued for these purposes and led a team in a heuristic evaluation of volunteer engagement, website or application usability, and participant retention. We received 40 completed survey responses (33% response rate) and completed a heuristic evaluation of 20 VCS program sites. The majority of the VCS programs focused on scientific outcomes, whereas the educational and social benefits of program participation, variables that are consistently ranked as important for volunteer engagement and retention, were incidental. Evaluators indicated usability, across most of the VCS program sites, was higher and less variable than the ratings for participant engagement and retention. In the context of growing competition for the attention of internet volunteers, increased attention to the motivations of virtual citizen scientists may help VCS programs sustain the necessary engagement and retention of their volunteers. PMID:26365126

  16. Development and characterization of a cell culture manufacturing process using quality by design (QbD) principles.

    Science.gov (United States)

    Marasco, Daniel M; Gao, Jinxin; Griffiths, Kristi; Froggatt, Christopher; Wang, Tongtong; Wei, Gan

    2014-01-01

    The principles of quality by design (QbD) have been applied in cell culture manufacturing process development and characterization in the biotech industry. Here we share our approach and practice in developing and characterizing a cell culture manufacturing process using QbD principles for establishing a process control strategy. Process development and characterization start with critical quality attribute identification, followed by process parameter and incoming raw material risk assessment, design of experiment, and process parameter classification, and conclude with a design space construction. Finally, a rational process control strategy is established and documented. PMID:23828505

  17. Design Principles for the Information Architecture of a SMET Education Digital Library.

    Science.gov (United States)

    Dong, Andy; Agogino, Alice M.

    This implementation paper introduces principles for the information architecture of an educational digital library, principles that address the distinction between designing digital libraries for education and designing digital libraries for information retrieval in general. Design is a key element of any successful product. Good designers and…

  18. Optical Design and Stray Light Concepts and Principles

    Science.gov (United States)

    Breault, Robert P.; Turner, Mary

    To insure that an optical system systemperforms to specifications, the optical engineer needs to fully consider several aspects of the design process. Each of these tasks can be aided with the use of software tools. The optical engineer needs to understand the strengths and limitations of the available software tools and how to best apply these programs to each design. There are several distinct steps in the implementation of an optical system: the first order optical layout, optimized design of the optical system, performing stray, scattered and ghost analysis, performing a tolerance analysis of the optical system and performing manufacturing analysis. Although each of these steps are often considered separately, and often require the use of several different software tools, it is imperative for the engineer to consider the entire process during each phase of system development so that issues arising from stray light or manufacturing tolerances do not force a redesign of the system. A thorough understanding of the optical design and analysis process as well as the proper use of available optical software tools are necessary to insure the optimum optical design for each specific application.

  19. Human Factors Principles in Design of Computer-Mediated Visualization for Robot Missions

    Energy Technology Data Exchange (ETDEWEB)

    David I Gertman; David J Bruemmer

    2008-12-01

    With increased use of robots as a resource in missions supporting countermine, improvised explosive devices (IEDs), and chemical, biological, radiological nuclear and conventional explosives (CBRNE), fully understanding the best means by which to complement the human operator’s underlying perceptual and cognitive processes could not be more important. Consistent with control and display integration practices in many other high technology computer-supported applications, current robotic design practices rely highly upon static guidelines and design heuristics that reflect the expertise and experience of the individual designer. In order to use what we know about human factors (HF) to drive human robot interaction (HRI) design, this paper reviews underlying human perception and cognition principles and shows how they were applied to a threat detection domain.

  20. Design principles in the development of (public) health information infrastructures.

    Science.gov (United States)

    Neame, Roderick

    2012-01-01

    In this article the author outlines the key issues in the development of a regional health information infrastructure suitable for public health data collections. A set of 10 basic design and development principles as used and validated in the development of the successful New Zealand National Health Information Infrastructure in 1993 are put forward as a basis for future developments. The article emphasises the importance of securing clinical input into any health data that is collected, and suggests strategies whereby this may be achieved, including creating an information economy alongside the care economy. It is suggested that the role of government in such developments is to demonstrate leadership, to work with the sector to develop data, messaging and security standards, to establish key online indexes, to develop data warehouses and to create financial incentives for adoption of the infrastructure and the services it delivers to users. However experience suggests that government should refrain from getting involved in local care services data infrastructure, technology and management issues.

  1. Design Principles and Algorithms for Air Traffic Arrival Scheduling

    Science.gov (United States)

    Erzberger, Heinz; Itoh, Eri

    2014-01-01

    This report presents design principles and algorithms for building a real-time scheduler of arrival aircraft based on a first-come-first-served (FCFS) scheduling protocol. The algorithms provide the conceptual and computational foundation for the Traffic Management Advisor (TMA) of the Center/terminal radar approach control facilities (TRACON) automation system, which comprises a set of decision support tools for managing arrival traffic at major airports in the United States. The primary objective of the scheduler is to assign arrival aircraft to a favorable landing runway and schedule them to land at times that minimize delays. A further objective of the scheduler is to allocate delays between high-altitude airspace far away from the airport and low-altitude airspace near the airport. A method of delay allocation is described that minimizes the average operating cost in the presence of errors in controlling aircraft to a specified landing time. This report is a revision of an earlier paper first presented as part of an Advisory Group for Aerospace Research and Development (AGARD) lecture series in September 1995. The authors, during vigorous discussions over the details of this paper, felt it was important to the air-trafficmanagement (ATM) community to revise and extend the original 1995 paper, providing more detail and clarity and thereby allowing future researchers to understand this foundational work as the basis for the TMA's scheduling algorithms.

  2. Embodied Language Learning and Cognitive Bootstrapping: Methods and Design Principles

    Directory of Open Access Journals (Sweden)

    Caroline Lyon

    2016-05-01

    Full Text Available Co-development of action, conceptualization and social interaction mutually scaffold and support each other within a virtuous feedback cycle in the development of human language in children. Within this framework, the purpose of this article is to bring together diverse but complementary accounts of research methods that jointly contribute to our understanding of cognitive development and in particular, language acquisition in robots. Thus, we include research pertaining to developmental robotics, cognitive science, psychology, linguistics and neuroscience, as well as practical computer science and engineering. The different studies are not at this stage all connected into a cohesive whole; rather, they are presented to illuminate the need for multiple different approaches that complement each other in the pursuit of understanding cognitive development in robots. Extensive experiments involving the humanoid robot iCub are reported, while human learning relevant to developmental robotics has also contributed useful results. Disparate approaches are brought together via common underlying design principles. Without claiming to model human language acquisition directly, we are nonetheless inspired by analogous development in humans and consequently, our investigations include the parallel co-development of action, conceptualization and social interaction. Though these different approaches need to ultimately be integrated into a coherent, unified body of knowledge, progress is currently also being made by pursuing individual methods.

  3. The principle of wave superposition applied to the quantum well laser and the motor-bike exhaust system

    Science.gov (United States)

    Jakovidis, Greg; McLeod, Ian D.; Morgan, Michael J.

    1990-05-01

    The use of simple ideas applied to 'real-world' situations is of considerable pedagogical value in teaching introductory physics. The principle of wave superposition is applied to understanding the physics of two very different devices: a quantum well laser and a motor-bike exhaust system. Reasonable agreement is found between the predictions of simple models, and the measured parameters of actual devices.

  4. HEURISTIC OPTIMIZATION AND ALGORITHM TUNING APPLIED TO SORPTIVE BARRIER DESIGN

    Science.gov (United States)

    While heuristic optimization is applied in environmental applications, ad-hoc algorithm configuration is typical. We use a multi-layer sorptive barrier design problem as a benchmark for an algorithm-tuning procedure, as applied to three heuristics (genetic algorithms, simulated ...

  5. Transformer design principles with applications to core-form power transformers

    CERN Document Server

    Del Vecchio, Robert M; Feeney, Mary-Ellen F

    2001-01-01

    Transformer Design Principles presents the theory of transformer operation and the methods and techniques of designing them. It emphasizes the physical principles and mathematical tools for simulating transformer behavior, including modern computer techniques. The scope of the book includes types of construction, circuit analysis, mechanical aspects of design, high voltage insulation requirements, and cooling design. The authors also address test procedures and reliability methods to assure successful design and discuss the economic analysis of designs. Summarizing material currently scattered

  6. Laser beam riding guided system principle and design research

    Science.gov (United States)

    Qu, Zhou; Jin, Yi; Xu, Zhou; Xing, Hao

    2016-01-01

    With the development of science and technology, precision-strike weapons has been considered to be important for winning victory in military field. Laser guidance is a major method to execute precision-strike in modern warfare. At present, the problems of primary stage of Laser guidance has been solved with endeavors of countries. Several technical aspects of laser-beam riding guided system have been mature, such as atmosphere penetration of laser beam, clutter inhibition on ground, laser irradiator, encoding and decoding of laser beam. Further, laser beam quality, equal output power and atmospheric transmission properties are qualified for warfare situation. Riding guidance instrument is a crucial element of Laser-beam riding guided system, and is also a vital element of airborne, vehicle-mounted and individual weapon. The optical system mainly consist of sighting module and laser-beam guided module. Photoelectric detector is the most important sensing device of seeker, and also the key to acquire the coordinate information of target space. Currently, in consideration of the 1.06 u m of wavelength applied in all the semi-active laser guided weapons systems, lithium drifting silicon photodiode which is sensitive to 1.06 u m of wavelength is used in photoelectric detector. Compared to Solid and gas laser, diode laser has many merits such as small volume, simple construction, light weight, long life, low lost and easy modulation. This article introduced the composition and operating principle of Laser-beam riding guided system based on 980 nm diode laser, and made a analysis of key technology; for instance, laser irradiator, modulating disk of component, laser zooming system. Through the use of laser diode, Laser-beam riding guided system is likely to have smaller shape and very light.

  7. Effective Principles in Designing E-Course in Light of Learning Theories

    Science.gov (United States)

    Afifi, Muhammad K.; Alamri, Saad S.

    2014-01-01

    The researchers conducted an exploratory study to determine the design quality of some E-courses delivered via the web to a number of colleagues at the university. Results revealed a number of shortcomings in the design of these courses, mostly due to the absence of effective principles in the design of these E-courses, especially principles of…

  8. Applying Delphi method for strategic design of social entrepreneurship

    OpenAIRE

    Κάβουρα, Ανδρονίκη; Andersson, Tuula; Kavoura, Androniki

    2016-01-01

    This paper aims to examine the strategic design for entrepreneurial activity. This study examines and evaluates a qualitative Delphi methodology used in a research for the strategy development needs of entrepreneurship counselling and education. The strategic design presented may well apply to non-profit organisations due to the fact that limited resources in funding of non-profit organisations exist. Design/methodology/approach – This paper introduces methodological considerations of applyin...

  9. Applying axiomatic design methodology in developing modified libertation products

    Directory of Open Access Journals (Sweden)

    Bibiana Margarita Vallejo Díaz

    2010-04-01

    Full Text Available Some conceptual elements regarding the axiomatic design method were applied to a specific case-study regarding developing modified liberation compressed product (CLM-UN, for use in the agricultural sector as pH regulating agent in solil. The study was orientated towards defining functional requeriments, design parameters and process variables for manufacturing the product. Independence and information were evaluated, supporting axiomatic design as an alternative for integral product and process design (as a rational and systemic exercise, facilitating producing products having the quality which future users expect from them.

  10. A game plan: Gamification design principles in mHealth applications for chronic disease management.

    Science.gov (United States)

    Miller, Aaron S; Cafazzo, Joseph A; Seto, Emily

    2016-06-01

    Effective chronic disease management is essential to improve positive health outcomes, and incentive strategies are useful in promoting self-care with longevity. Gamification, applied with mHealth (mobile health) applications, has the potential to better facilitate patient self-management. This review article addresses a knowledge gap around the effective use of gamification design principles, or mechanics, in developing mHealth applications. Badges, leaderboards, points and levels, challenges and quests, social engagement loops, and onboarding are mechanics that comprise gamification. These mechanics are defined and explained from a design and development perspective. Health and fitness applications with gamification mechanics include: bant which uses points, levels, and social engagement, mySugr which uses challenges and quests, RunKeeper which uses leaderboards as well as social engagement loops and onboarding, Fitocracy which uses badges, and Mango Health, which uses points and levels. Specific design considerations are explored, an example of the efficacy of a gamified mHealth implementation in facilitating improved self-management is provided, limitations to this work are discussed, a link between the principles of gaming and gamification in health and wellness technologies is provided, and suggestions for future work are made. We conclude that gamification could be leveraged in developing applications with the potential to better facilitate self-management in persons with chronic conditions. PMID:24986104

  11. A game plan: Gamification design principles in mHealth applications for chronic disease management.

    Science.gov (United States)

    Miller, Aaron S; Cafazzo, Joseph A; Seto, Emily

    2016-06-01

    Effective chronic disease management is essential to improve positive health outcomes, and incentive strategies are useful in promoting self-care with longevity. Gamification, applied with mHealth (mobile health) applications, has the potential to better facilitate patient self-management. This review article addresses a knowledge gap around the effective use of gamification design principles, or mechanics, in developing mHealth applications. Badges, leaderboards, points and levels, challenges and quests, social engagement loops, and onboarding are mechanics that comprise gamification. These mechanics are defined and explained from a design and development perspective. Health and fitness applications with gamification mechanics include: bant which uses points, levels, and social engagement, mySugr which uses challenges and quests, RunKeeper which uses leaderboards as well as social engagement loops and onboarding, Fitocracy which uses badges, and Mango Health, which uses points and levels. Specific design considerations are explored, an example of the efficacy of a gamified mHealth implementation in facilitating improved self-management is provided, limitations to this work are discussed, a link between the principles of gaming and gamification in health and wellness technologies is provided, and suggestions for future work are made. We conclude that gamification could be leveraged in developing applications with the potential to better facilitate self-management in persons with chronic conditions.

  12. Applying complexity theory: a review to inform evaluation design.

    Science.gov (United States)

    Walton, Mat

    2014-08-01

    Complexity theory has increasingly been discussed and applied within evaluation literature over the past decade. This article reviews the discussion and use of complexity theory within academic journal literature. The aim is to identify the issues to be considered when applying complexity theory to evaluation. Reviewing 46 articles, two groups of themes are identified. The first group considers implications of applying complexity theory concepts for defining evaluation purpose, scope and units of analysis. The second group of themes consider methodology and method. Results provide a starting point for a configuration of an evaluation approach consistent with complexity theory, whilst also identifying a number of design considerations to be resolved within evaluation planning.

  13. Integrating Quality Matters into Hybrid Course Design: A Principles of Marketing Case Study

    Science.gov (United States)

    Young, Mark R.

    2014-01-01

    Previous research supports the idea that the success of hybrid or online delivery modes is more a function of course design than delivery media. This article describes a case study of a hybrid Principles of Marketing course that implemented a comprehensive redesign based on design principles espoused by the Quality Matters Program, a center for…

  14. 10 CFR 435.6 - Sustainable principles for siting, design and construction. [Reserved

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Sustainable principles for siting, design and construction. 435.6 Section 435.6 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY STANDARDS FOR... Residential Buildings. § 435.6 Sustainable principles for siting, design and construction....

  15. 10 CFR 433.6 - Sustainable principles for siting, design and construction. [Reserved

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Sustainable principles for siting, design and construction. 433.6 Section 433.6 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY STANDARDS FOR... § 433.6 Sustainable principles for siting, design and construction....

  16. Design of Learning Objects for Concept Learning: Effects of Multimedia Learning Principles and an Instructional Approach

    Science.gov (United States)

    Chiu, Thomas K. F.; Churchill, Daniel

    2016-01-01

    Literature suggests using multimedia learning principles in the design of instructional material. However, these principles may not be sufficient for the design of learning objects for concept learning in mathematics. This paper reports on an experimental study that investigated the effects of an instructional approach, which includes two teaching…

  17. Design Principles for Serious Video Games in Mathematics Education: From Theory to Practice

    OpenAIRE

    Konstantinos Chorianopoulos; Michail Giannakos

    2014-01-01

    There is growing interest in the employment of serious video games in science education, but there are no clear design principles. After surveying previous work in serious video game design, we highlighted the following design principles: 1) engage the students with narrative (hero, story), 2) employ familiar gameplay mechanics from popular video games, 3) engage students into constructive trial and error game-play and 4) situate collaborative learning. As illustrated examples we designed two...

  18. Design Principles for the Development of the Balanced Scorecard

    Science.gov (United States)

    Keser Ozmantar, Zehra; Gedikoglu, Tokay

    2016-01-01

    Purpose: The purpose of this paper is to investigate the development and implementation process of the balanced scorecard (BSC) approach in an educational institution in the context of the Turkish educational system. It also aims, on the basis of the results of the applications in a particular school, to define principles through which the…

  19. Content Analysis and Readibility Formulas as Applied To The Accounting Principles Board "Opinions"

    Science.gov (United States)

    Stead, Bette Ann

    1977-01-01

    Discusses a study analyzing twenty-four of the Accounting Principles Board "Opinions" (APB Opinions) and concludes that the APB context is very difficult to read and understand for both accounting and nonaccounting majors. (MH)

  20. How the Principle of Risk Management Can Be Applied to Different Types of Projects?

    OpenAIRE

    Yuanyuan Zhang

    2009-01-01

    Project risk management is a process which combines the analysis and management of the risks with a project and the principles of risk management include two key points which are risk analysis and risk control and arrangement. The case studies clarify the principles of project risk management can be used in different types of projects, and also when doing risk management it should be followed by right steps, choosing the right analysis methods, quantifying the risks precisely and formulating ...

  1. Agile Principles Applied to a Complex Long Term Research Activity - The PERIMETER Approach

    OpenAIRE

    Dillon, Eileen; Sivrikaya, Fikret; Haemmerle, Christian; Salgarelli, Luca

    2009-01-01

    Agile software development is a group of software development methodologies that are based on similar principles, as defined in the Agile Manifesto. Agile software projects are characterized by iterative and incremental development, accommodation of changes and active customer participation. The popularity of agile principles is steadily increasing. Their adopters report that this development process leads to higher software quality and customer satisfaction ratings when compared to using ...

  2. Culture change in infection control: applying psychological principles to improve hand hygiene.

    Science.gov (United States)

    Cumbler, Ethan; Castillo, Leilani; Satorie, Laura; Ford, Deborah; Hagman, Jan; Hodge, Therese; Price, Lisa; Wald, Heidi

    2013-01-01

    Hand hygiene occurs at the intersection of habit and culture. Psychological and social principles, including operant conditioning and peer pressure of conforming social norms, facilitate behavior change. Participatory leadership and level hierarchies are needed for sustainable patient safety culture. Application of these principles progressively and significantly improved hand hygiene compared with the hospital aggregate control. Changes to hand hygiene auditing and response processes demonstrate ability to improve and sustain adherence rates within a clinical microsystem. PMID:23669615

  3. Teaching scientific principles through a computer-based, design-centered learning environment

    Science.gov (United States)

    Wolfe, Michael Brian

    Research on science instruction indicates that the traditional science classroom is not always effective in improving students' scientific understanding. Physics courses, in particular, do not promote the ability to apply scientific principles for many reasons, based on their focus on procedural problem-solving and lab exercises. In this dissertation, I propose the Designing-to-Learn Architecture (DTLA), a design-centered goal-based scenario (GBS) architecture, theoretically grounded in the literature on design-centered learning environments, goal-based scenarios, intelligent tutoring systems and simulations. The DTLA offers an alternative approach to addressing the issues encountered in the traditional science classroom. The architecture consists of an artifact with associated design goals; components with component options; a simulation; a reference database; and guided tutorials. I describe the design of Goin' Up?, the prototype DTL application, serving as the basis for evaluating the effectiveness of the DTLA. I present results of interview and testing protocols from the formative evaluation of Goin' Up?, suggesting that learning outcomes, though not statistically significant, could be improved through DTLA enhancements informed by usage patterns in software sessions. I conclude with an analysis of the results and suggestions for improvements to the DTLA, including additional components to address reflection, provide support for novice designers, and offer tutorial guidance on the analysis of the artifact.

  4. Natural Stone Waste Powders Applied to SCC Mix Design

    NARCIS (Netherlands)

    Hunger, M.; Brouwers, H.J.H.

    2008-01-01

    In order to comply with current trends concerning sustainability, saving of primary materials and energy savings, this paper addresses Eco-concrete. The major focus thereby is on the increased efficiency of cement use. Applying a new mix design method for concrete, cement contents can be decreased a

  5. Bionic Concept Applied to Flow Slab Design of PEMFC

    Science.gov (United States)

    Wang, C. T.; Chang, C. P.

    A character of fuel cell with high potency and low pollution was known well and considered as a new generation of power technology. In this study a novel design of flow slab addressed and originated from bionic concept will be applied to improve the performance of PEMFC. Simulation results executed at Re = 100 show that the bionic flow type will possess a better uniformity of velocity and lower pressure drop. Besides, the integral performance concerned at SDR and PDR will also show the bionic flow type to be an outstanding design. Hence, this novel flow design addressed will be useful to promotion of PEMFC.

  6. Universal Design in Postsecondary Education: Process, Principles, and Applications

    Science.gov (United States)

    Burgstahler, Sheryl

    2009-01-01

    Designing any product or environment involves the consideration of many factors, including aesthetics, engineering options, environmental issues, safety concerns, industry standards, and cost. Typically, designers focus their attention on the average user. In contrast, universal design (UD), according to the Center for Universal Design, "is the…

  7. Applying Adaptive Agricultural Management & Industrial Ecology Principles to Produce Lower- Carbon Ethanol from California Energy Beets

    Science.gov (United States)

    Alexiades, Anthy Maria

    The life cycle assessment of a proposed beet-to-ethanol pathway demonstrates how agricultural management and industrial ecology principles can be applied to reduce greenhouse gas emissions, minimize agrochemical inputs and waste, provide ecosystem services and yield a lower-carbon fuel from a highly land-use efficient, first-generation feedstock cultivated in California. Beets grown in California have unique potential as a biofuel feedstock. A mature agricultural product with well-developed supply chains, beet-sugar production in California has contracted over recent decades, leaving idle production capacity and forcing growers to seek other crops for use in rotation or find a new market for beets. California's Low Carbon Fuel Standard (LCFS) faces risk of steeply-rising compliance costs, as greenhouse gas reduction targets in the transportation sector were established assuming commercial volumes of lower-carbon fuels from second-generation feedstocks -- such as residues, waste, algae and cellulosic crops -- would be available by 2020. The expected shortfall of cellulosic ethanol has created an immediate need to develop lower-carbon fuels from readily available feedstocks using conventional conversion technologies. The life cycle carbon intensity of this ethanol pathway is less than 28 gCO2e/MJEthanol: a 72% reduction compared to gasoline and 19% lower than the most efficient corn ethanol pathway (34 gCO2e/MJ not including indirect land use change) approved under LCFS. The system relies primarily on waste-to-energy resources; nearly 18 gCO2e/MJ are avoided by using renewable heat and power generated from anaerobic digestion of fermentation stillage and gasification of orchard residues to meet 88% of the facility's steam demand. Co-products displace 2 gCO2e/MJ. Beet cultivation is the largest source of emissions, contributing 15 gCO 2e/MJ. The goal of the study is to explore opportunities to minimize carbon intensity of beet-ethanol and investigate the potential

  8. Applying riding-posture optimization on bicycle frame design.

    Science.gov (United States)

    Hsiao, Shih-Wen; Chen, Rong-Qi; Leng, Wan-Lee

    2015-11-01

    Customization design is a trend for developing a bicycle in recent years. Thus, the comfort of riding a bike is an important factor that should be paid much attention to while developing a bicycle. From the viewpoint of ergonomics, the concept of "fitting object to the human body" is designed into the bicycle frame in this study. Firstly, the important feature points of riding posture were automatically detected by the image processing method. In the measurement process, the best riding posture was identified experimentally, thus the positions of feature points and joint angles of human body were obtained. Afterwards, according to the measurement data, three key points: the handlebar, the saddle and the crank center, were identified and applied to the frame design of various bicycle types. Lastly, this study further proposed a frame size table for common bicycle types, which is helpful for the designer to design a bicycle. PMID:26154206

  9. Top 10 principles for designing healthy coastal ecosystems like the Salish Sea

    Science.gov (United States)

    Gaydos, Joseph K.; Dierauf, Leslie; Kirby, Grant; Brosnan, Deborah; Gilardi, Kirsten; Davis, Gary E.

    2008-01-01

    Like other coastal zones around the world, the inland sea ecosystem of Washington (USA) and British Columbia (Canada), an area known as the Salish Sea, is changing under pressure from a growing human population, conversion of native forest and shoreline habitat to urban development, toxic contamination of sediments and species, and overharvest of resources. While billions of dollars have been spent trying to restore other coastal ecosystems around the world, there still is no successful model for restoring estuarine or marine ecosystems like the Salish Sea. Despite the lack of a guiding model, major ecological principles do exist that should be applied as people work to design the Salish Sea and other large marine ecosystems for the future. We suggest that the following 10 ecological principles serve as a foundation for educating the public and for designing a healthy Salish Sea and other coastal ecosystems for future generations: (1) Think ecosystem: political boundaries are arbitrary; (2) Account for ecosystem connectivity; (3) Understand the food web; (4) Avoid fragmentation; (5) Respect ecosystem integrity; (6) Support nature's resilience; (7) Value nature: it's money in your pocket; (8) Watch wildlife health; (9) Plan for extremes; and (10) Share the knowledge.

  10. Graphical symbols -- Safety colours and safety signs -- Part 1: Design principles for safety signs in workplaces and public areas

    CERN Document Server

    International Organization for Standardization. Geneva

    2002-01-01

    This International Standard establishes the safety identification colours and design principles for safety signs to be used in workplaces and in public areas for the purpose of accident prevention, fire protection, health hazard information and emergency evacuation. It also establishes the basic principles to be applied when developing standards containing safety signs. This part of ISO 3864 is applicable to workplaces and all locations and all sectors where safety-related questions may be posed. However, it is not applicable to the signalling used for guiding rail, road, river, maritime and air traffic and, generally speaking, to those sectors subject to a regulation which may differ.

  11. Applying the maximum information principle to cell transmission model of tra-ffic flow

    Institute of Scientific and Technical Information of China (English)

    刘喜敏; 卢守峰

    2013-01-01

    This paper integrates the maximum information principle with the Cell Transmission Model (CTM) to formulate the velo-city distribution evolution of vehicle traffic flow. The proposed discrete traffic kinetic model uses the cell transmission model to cal-culate the macroscopic variables of the vehicle transmission, and the maximum information principle to examine the velocity distri-bution in each cell. The velocity distribution based on maximum information principle is solved by the Lagrange multiplier method. The advantage of the proposed model is that it can simultaneously calculate the hydrodynamic variables and velocity distribution at the cell level. An example shows how the proposed model works. The proposed model is a hybrid traffic simulation model, which can be used to understand the self-organization phenomena in traffic flows and predict the traffic evolution.

  12. The Impact of People-Oriented Principle on Package Design

    Institute of Scientific and Technical Information of China (English)

    侯咏雪

    2014-01-01

    In modern design, it’s frequently advocated to adopt the recyclable and sustainable design as well as to use green and sustainable materials, which is a manifestation of the harmony between man and the nature.

  13. Using a problem-solving strategy to train students to apply general principles and to improve students' epistemology

    Science.gov (United States)

    McCoy, B.

    2011-12-01

    General studies science classes at many universities, such as physical science, Earth science, or astronomy, stress memorization and repetition of concepts. This approach leaves students with little appreciation for how science is used to explain phenomena from general principles. We present a novel instructional technique for an Earth science class in which the students are instructed in the use of a general problem solving strategy, adapted from a quantitative problem solving strategy developed by physics education research, in order to train the students in how to apply general principles. Using the Epistemological Beliefs Assessment for Physical Science, we have found that explicit training in problem solving significantly improves students' epistemology.

  14. Applied predictive analytics principles and techniques for the professional data analyst

    CERN Document Server

    Abbott, Dean

    2014-01-01

    Learn the art and science of predictive analytics - techniques that get results Predictive analytics is what translates big data into meaningful, usable business information. Written by a leading expert in the field, this guide examines the science of the underlying algorithms as well as the principles and best practices that govern the art of predictive analytics. It clearly explains the theory behind predictive analytics, teaches the methods, principles, and techniques for conducting predictive analytics projects, and offers tips and tricks that are essential for successful predictive mode

  15. Teaching principles of qualitative analysis to industrial design engineers

    NARCIS (Netherlands)

    Stappers, P.J.

    2012-01-01

    Doing qualitative field research has become a standard part of academic human-centered design education. Part of the challenge is to bring design students a thorough understanding of research methods, and practical skills in performing small scale user research as part of design projects. This invo

  16. A Learning and Interaction design framework, from a study on formulating principles for the design of engaging music learning games

    DEFF Research Database (Denmark)

    Weitze, Charlotte Lærke; Ørngreen, Rikke

    2012-01-01

    Based on a preliminary action research study investigating the design of digital music games and years of experiences from interaction design processes of learning resources, this extended abstract presents a framework that mixes designs for learning principles and game design with a process view...

  17. Magnetoelectic multiferroic superlattices and interfaces: Designing spintronic materials from first principles

    Science.gov (United States)

    Zanolli, Zeila

    2015-03-01

    The research challenges of the near and far future in electronics focus on the quest for new materials and novel device concepts to achieve low energy consumption, increased reliability and high device density. These can be obtained by designing active elements and interconnects whose operating principle is not (only) based on the electron charge but on the spin degree of freedom of the electron. The nanoscopic size of the materials calls for atomistic and parameter free (ab initio) simulations, which have proven to be crucial in achieving the necessary accuracy and predictive power. Materials which present a coupling between ferroelectricity and magnetism, i.e. magnetoelectric (ME) multiferroics, have been proposed as fundamental building blocks for spintronic devices. However ferroelectricity and magnetism are often exclusive or weakly coupled in bulk. In this talk, we will discuss how superlattices of perovskites can be designed from first principles to achieve strongly coupled ME and, hence, achieve control the weak magnetization via an electric field. Most important, advanced epitaxial techniques allow one to actually grow such magnetoelectric superlattices. Another route to optimize spintronic devices is to exploit the unique electronic and transport properties of Carbon-based nanomaterials. The latter present spin diffusion lengths up to 100 μm and high electron velocity. However, a large spin diffusion length comes at the price of small Spin Orbit coupling, which limits the possibility of manipulating electrons via an external applied field. Further, to achieve graphene-based devices one also needs to open its vanishing electronic gap. We use first principle techniques to show that placing graphene on a ME substrate can overcome these limitations by inducing magnetism and opening an electronic band-gap in the hybrid organic-multiferroic material. Z.Z. acknowledges EC support under the Marie-Curie IEF (PIEF-Ga-2011-300036), computational resources from the

  18. Experimental designs for autoregressive models applied to industrial maintenance

    International Nuclear Information System (INIS)

    Some time series applications require data which are either expensive or technically difficult to obtain. In such cases scheduling the points in time at which the information should be collected is of paramount importance in order to optimize the resources available. In this paper time series models are studied from a new perspective, consisting in the use of Optimal Experimental Design setup to obtain the best times to take measurements, with the principal aim of saving costs or discarding useless information. The model and the covariance function are expressed in an explicit form to apply the usual techniques of Optimal Experimental Design. Optimal designs for various approaches are computed and their efficiencies are compared. The methods working in an application of industrial maintenance of a critical piece of equipment at a petrochemical plant are shown. This simple model allows explicit calculations in order to show openly the procedure to find the correlation structure, needed for computing the optimal experimental design. In this sense the techniques used in this paper to compute optimal designs may be transferred to other situations following the ideas of the paper, but taking into account the increasing difficulty of the procedure for more complex models. - Highlights: • Optimal experimental design theory is applied to AR models to reduce costs. • The first observation has an important impact on any optimal design. • Either the lack of precision or small starting observations claim for large times. • Reasonable optimal times were obtained relaxing slightly the efficiency. • Optimal designs were computed in a predictive maintenance context

  19. Signaled Stopping and Cognitive, Language Principles Applied to Public Relations Writing.

    Science.gov (United States)

    Ramsey, Shirley A.

    To investigate the hypothesis that cognitive rules govern writing behavior, Carter's signaled stopping technique was used to study language and cognitive effects in public relations messages. Principles from Grunig, et al (1985) Axiomatic Theory of Cognition and Writing, which proposed premises, axioms and definitions about writing, were applied…

  20. Module Cluster: TTP-005.00 (GSC). Applied Behavior Analysis Principles.

    Science.gov (United States)

    Brent, George; And Others

    This module cluster enables (a) students to operationally define various classroom behaviors; (b) define and utilize behavioral principles; and (c) correctly employ measurement methods which facilitate information gathering, monitoring, and management of academic and/or "problem" classroom behaviors. It contains modules in the following ten areas:…

  1. Applying the Principle of Dynamic Equivalence in the Translation of the Heading of News Report

    Institute of Scientific and Technical Information of China (English)

    赵宁

    2008-01-01

    Nida's famous notion of Dynamic Equivalence in translation process is characterized by three stages - analysis,transfer and restructuring,which age explained in detail.The application of these principles are illustrated by providing step-by-step explanation on the translation process of headings of two news reports,which age selected from Far Eastern Economic Review.

  2. Huygens-Feynman-Fresnel principle as the basis of applied optics.

    Science.gov (United States)

    Gitin, Andrey V

    2013-11-01

    The main relationships of wave optics are derived from a combination of the Huygens-Fresnel principle and the Feynman integral over all paths. The stationary-phase approximation of the wave relations gives the correspondent relations from the point of view of geometrical optics.

  3. Applying Lean principles and Kaizen rapid improvement events in public health practice.

    Science.gov (United States)

    Smith, Gene; Poteat-Godwin, Annah; Harrison, Lisa Macon; Randolph, Greg D

    2012-01-01

    This case study describes a local home health and hospice agency's effort to implement Lean principles and Kaizen methodology as a rapid improvement approach to quality improvement. The agency created a cross-functional team, followed Lean Kaizen methodology, and made significant improvements in scheduling time for home health nurses that resulted in reduced operational costs, improved working conditions, and multiple organizational efficiencies.

  4. Friction reduction using discrete surface textures: principle and design

    International Nuclear Information System (INIS)

    There have been many reports on the use of dimples, grooves, and other surface textures to control friction in sliding interfaces. The effectiveness of surface textures in friction reduction has been demonstrated in conformal contacts under high speed low load applications such as mechanical seals and automotive water pump seals, etc., resulting in reduced friction and longer durability. For sliding components with higher contact pressures or lower speeds, conflicting results were reported. Reasons for the inconsistency may be due to the differences in texture fabrication techniques, lack of dimple size and shape uniformity, and different tester used. This paper examines the basic principles on which surface textural patterns influence friction under the three principle lubrication regimes: hydrodynamic, elastohydrodynamic, and boundary lubrication regimes. Our findings suggest that each regime requires specific dimple size, shape, depth, and areal density to achieve friction reduction. Control experiments were also conducted to explore mechanisms of friction reduction. The dimple geometric shape and the dimple's orientation with respect to the sliding direction influence friction significantly. The underlying mechanisms for friction control via textures are discussed. (paper)

  5. Teaching the Principles of Effective Online Course Design: What Works?

    OpenAIRE

    Clare Gormley

    2014-01-01

    While much has been written about the pedagogy and challenges of online learning, there is comparatively little research that advises how online course design competencies can be achieved. Certainly a growing range of course design resources is being created and made openly available, but there is a need to evaluate their actual impact on practice. This predominantly qualitative study describes the impact of two learning interventions – open online tutorials and a design and development works...

  6. Semantic Differential applied to the evaluation of machine tool design

    OpenAIRE

    Mondragón Donés, Salvador; Company, Pedro; Vergara Monedero, Margarita

    2005-01-01

    In this article, a study is presented showing that Product Semantics (PS) can be used to study the design of machine tools. Nowadays, different approaches to PS (Semantic Differential, Kansei Engineering, etc.) are being applied to consumer products with successful results, but commercial products have generally received less attention and machine tools in particular have not yet been studied. Our second objective is to measure the different sensitivities that the different groups of the popu...

  7. Performance Assessment Design Principles Gleaned from Constructivist Learning Theory (Part 2)

    Science.gov (United States)

    Zane, Thomas W.

    2009-01-01

    Just as objectivist theories have provided foundations for traditional tests, constructivist theories can offer foundations for performance assessment design and development methods. The tenets and principles embedded in various learning theories provide a solid foundation that can be combined with psychometric principles to help assessment…

  8. Performance Assessment Design Principles Gleaned from Constructivist Learning Theory (Part 1)

    Science.gov (United States)

    Zane, Thomas W.

    2009-01-01

    Just as objectivist theories have provided foundations for traditional tests, constructivist theories can offer foundations for performance assessment design and development methods. The tenets and principles embedded in various learning theories provide a solid foundation that can be combined with psychometric principles to help assessment…

  9. Some Principles for the Design of Clarifying Educational Environments. Preprint 32.

    Science.gov (United States)

    Moore, Omar K.; Anderson, Alan Ross

    The author's purpose in this paper is to explain and illustrate four principles for designing learning environments within which even young children can acquire complex symbolic skills with relative ease. After discussing the principles themselves and the theoretical system out of which they emerged, the author considers an illustrative…

  10. Inclusivity, Gestalt Principles, and Plain Language in Document Design

    Directory of Open Access Journals (Sweden)

    Jennifer Turner

    2016-06-01

    Full Text Available In Brief: Good design makes documents easier to use, helps documents stand out from other pieces of information, and lends credibility to document creators. Librarians across library types and departments provide instruction and training materials to co-workers and library users. For these materials to be readable and accessible, they must follow guidelines for usable document design. […

  11. Principles and Concepts for Information and Communication Technology Design.

    Science.gov (United States)

    Adams, Ray; Langdon, Patrick

    2003-01-01

    This article presents a theory for evaluating information and communication technology design for individuals with disabilities. Simplex 1 evaluates designs in five zones: sensory and input zone; output zone; abstract working memory; long-term memory; and central executive functioning. Simplex 2 evaluates feedback, emotional responses, cognitive…

  12. Relevant cost and financial ratio principles applied in a small business / G.P. Simpson.

    OpenAIRE

    Simpson, Gabriël Pieter

    2012-01-01

    Cost-Volume-Profit (CVP) analysis and financial ratios are all managerial accounting and financial accounting tools that can help managers to make informative business decisions within their organisations. In addition, certain strategic tools such as Porters five forces, SWOT analysis, identifying of core principles, the compilation of the vision and mission statement will empower the small to medium business to be successful as an entrepreneurial venture. The problem arises in many small ...

  13. Applying Lean principles and Kaizen rapid improvement events in public health practice.

    Science.gov (United States)

    Smith, Gene; Poteat-Godwin, Annah; Harrison, Lisa Macon; Randolph, Greg D

    2012-01-01

    This case study describes a local home health and hospice agency's effort to implement Lean principles and Kaizen methodology as a rapid improvement approach to quality improvement. The agency created a cross-functional team, followed Lean Kaizen methodology, and made significant improvements in scheduling time for home health nurses that resulted in reduced operational costs, improved working conditions, and multiple organizational efficiencies. PMID:22139310

  14. Maximum Principle for Linear-Convex Boundary Control Problems applied to Optimal Investment with Vintage Capital

    OpenAIRE

    Faggian, Silvia

    2007-01-01

    The paper concerns the study of the Pontryagin Maximum Principle for an infinite dimensional and infinite horizon boundary control problem for linear partial differential equations. The optimal control model has already been studied both in finite and infinite horizon with Dynamic Programming methods in a series of papers by the same author, or by Faggian and Gozzi. Necessary and sufficient optimality conditions for open loop controls are established. Moreover the co-state variable is shown t...

  15. Do Chickering and Gamson's Seven Principles Also Apply to Online MBAs?

    Directory of Open Access Journals (Sweden)

    J. B. (Ben Arbaugh

    2006-07-01

    Full Text Available Given a relative lack of empirical testing of conceptual frameworks of web-based course effectiveness, empirical testing of such frameworks is important because it can help determine similarities and/or differences in web-based and classroom-based courses. Such frameworks help determine whether and/or to what extent the training of faculty must be modified to prepare them adequately for online teaching. To assess whether conventional teaching wisdom needs to be modified for the online learning environment, we tested the applicability of a commonly-used framework, Chickering and Gamson’s (1987 Seven Principles of Good Practice in Education using a sample of twenty-four online MBA courses conducted at two Midwestern U. S. schools. The results support the extension of five from the seven principles of good practice in classroom-based undergraduate education to web-based graduate education. These findings suggest that principles of effective classroom teaching may be used as a starting point for developing and teaching web-based courses.

  16. Ethics of Living Technology: Design Principles for Proactive Home Environments

    Directory of Open Access Journals (Sweden)

    Frans Mäyrä

    2004-07-01

    Full Text Available The entry of proactive technology into highly sensitive environments, such as the home, produces specific design challenges that are inextricably linked to ethical issues. Two design goals are presented and analysed: proactive solutions have to be both personalized and consistent. These requirements are partially contradictory, and need to be understood in the context of the socio-cognitive setting of the home. The embedding of proactive technology into a home environment has to provide the user with an awareness of the possibilities of control and play. These design goals are further developed with regard to different user cultures: here we concentrate on early adopters and elderly people.

  17. SOA and Web services interface design principles, techniques, and standards

    CERN Document Server

    Bean, James

    2009-01-01

    SOA offers solutions to the most intractable business problems faced by every enterprise, but getting the SOA service interface right requires the practical design knowledge this book uniquely delivers

  18. Constructal Law and the Unifying Principle of Design

    CERN Document Server

    Lorente, Sylvie; Bejan, Adrian

    2013-01-01

    Design happens everywhere, whether in animate objects (e.g., dendritic lung structures, bacterial colonies, and corals), inanimate patterns (river basins, beach slope, and dendritic crystals), social dynamics (pedestrian traffic flows), or engineered systems (heat dissipation in electronic circuitry). This “design in nature” often takes on remarkably similar patterns, which can be explained under one unifying Constructal Law. This book explores the unifying power of the Constructal Law and its applications in all domains of design generation and evolution, ranging from biology and geophysics to globalization, energy, sustainability, and security.  The Constructal Law accounts for the universal tendency of flow systems to morph into evolving configurations that provide greater and easier access over time. The Constructal Law resolves the many and contradictory ad hoc statements of “optimality”, end design, and destiny in nature, such as minimum and maximum entropy production and minimum and maximum fl...

  19. Ultra-thin oxide films for band engineering: design principles and numerical experiments

    Energy Technology Data Exchange (ETDEWEB)

    Butler, Keith T.; Walsh, Aron, E-mail: a.walsh@bath.ac.uk

    2014-05-30

    The alignment of band energies between conductive oxides and semiconductors is crucial for the further development of oxide contacting layers in electronic devices. The growth of ultra thin films on the surface of an oxide material can be used to introduce a dipole moment at that surface due to charge differences. The dipole, in turn, alters the electrostatic potential — and hence the band energies — in the substrate oxide. We demonstrate the fundamental limits for the application of thin-films in this context, applying analytical and numerical simulations, that bridge continuum and atomistic. The simulations highlight the different parameters that can affect the band energy shifting potential of a given thin-film layer, taking the examples of MgO and SnO{sub 2}. In particular we assess the effect of formal charge, layer orientation, layer thickness and surface coverage, with respect to their effect on the electrostatic potential. The results establish some design principles, important for further development and application of thin-films for band energy engineering in transparent conductive oxide materials. - Highlights: • Bridging continuum electrostatics and numerical point charge simulations. • Principles for engineering of band energies through application of ultra-thin films. • Effects of thin-film orientation on band energy levels • Effects of film-coverage and thickness on band energy levels.

  20. Issues in Applying Bio-Inspiration, Cognitive Critical Mass and Developmental-Inspired Principles to Advanced Intelligent Systems

    Science.gov (United States)

    Berg-Cross, Gary; Samsonovich, Alexei V.

    This Chapter summarizes ideas presented at the special PerMIS 2008 session on Biological Inspiration for Intelligent Systems. Bio-inspired principles of development and evolution are a special part of the bio-models and principles that can be used to improve intelligent systems and related artifacts. Such principles are not always explicit. They represent an alternative to incremental engineering expansion using new technology to replicate human intelligent capabilities. They are more evident in efforts to replicate and produce a “critical mass” of higher cognitive functions of the human mind or their emergence through cognitive developmental robotics (DR) and self-regulated learning (SRL). DR approaches takes inspiration from natural processes, so that intelligently engineered systems may create solutions to problems in ways similar to what we hypothesize is occurring with biologics in their natural environment. This Chapter discusses how an SRL-based approach to bootstrap a “critical mass” can be assessed by a set of cognitive tests. It also uses a three-level bio-inspired framework to illustrate methodological issues in DR research. The approach stresses the importance of using bio-realistic developmental principles to guide and constrain research. Of particular importance is keeping models and implementation separate to avoid the possible of falling into a Ptolemaic paradigm that may lead to endless tweaking of models. Several of Lungarella's design principles [36] for developmental robotics are discussed as constraints on intelligence as it emerges from an ecologically balanced, three-way interaction between an agents' control systems, physical embodiment, and the external environment. The direction proposed herein is to explore such principles to avoid slavish following of superficial bio-inspiration. Rather we should proceed with a mature and informed developmental approach using developmental principles based on our incremental understanding of how

  1. Function and principle innovative design of mechanical products based on TRIZ/FA

    Institute of Scientific and Technical Information of China (English)

    YUAN Feng; WANG Tai-yong; NIE Hui-juan

    2006-01-01

    Function and principle innovation is the ultimate innovation of a product.To achieve Function and principle innovation design of mechanical products,a new process model of function and principle solving is proposed,based on TRIZ and FA.In this model,abstraction of general function,confirmation of principle solution to general function,and functional decomposition were included in FA.Confirmation of principle solution to general function was the premise of functional decomposition.To provide a dependable pattern for functional decomposition,a new functional analysis method was put forward based on the generalized process function along with the introduction of the input constraint function;and its five-decomposition-steps were also presented.To provide powerful support for innovation design tools in principle solution,some TRIZ tools in the model were imbedded,such as SU-field Analysis,Scientific Effects,and Contradiction Solving Principles so as to boost up the innovation of principle solution.As a case study,an innovative design of paint-bottling machine has been achieved with application of the proposed model.

  2. Adaptive Robotic Systems Design in University of Applied Sciences

    Directory of Open Access Journals (Sweden)

    Gunsing Jos

    2016-01-01

    Full Text Available In the industry for highly specialized machine building (small series with high variety and high complexity and in healthcare a demand for adaptive robotics is rapidly coming up. Technically skilled people are not always available in sufficient numbers. A lot of know how with respect to the required technologies is available but successful adaptive robotic system designs are still rare. In our research at the university of applied sciences we incorporate new available technologies in our education courses by way of research projects; in these projects students will investigate the application possibilities of new technologies together with companies and teachers. Thus we are able to transfer knowledge to the students including an innovation oriented attitude and skills. Last years we developed several industrial binpicking applications for logistics and machining-factories with different types of 3D vision. Also force feedback gripping has been developed including slip sensing. Especially for healthcare robotics we developed a so-called twisted wire actuator, which is very compact in combination with an underactuated gripper, manufactured in one piece in polyurethane. We work both on modeling and testing the functions of these designs but we work also on complete demonstrator systems. Since the amount of disciplines involved in complex product and machine design increases rapidly we pay a lot of attention with respect to systems engineering methods. Apart from the classical engineering disciplines like mechanical, electrical, software and mechatronics engineering, especially for adaptive robotics more and more disciplines like industrial product design, communication … multimedia design and of course physics and even art are to be involved depending on the specific application to be designed. Design tools like V-model, agile/scrum and design-approaches to obtain the best set of requirements are being implemented in the engineering studies from

  3. In Search of Design Principles for Developing Digital Learning and Performance Support for a Student Design Task

    Science.gov (United States)

    Bollen, Lars; van der Meij, Hans; Leemkuil, Henny; McKenney, Susan

    2015-01-01

    A digital learning and performance support environment for university student design tasks was developed. This paper describes on the design rationale, process, and the usage results to arrive at a core set of design principles for the construction of such an environment. We present a collection of organizational, technical, and course-related…

  4. Effective Principles In Designing E-Course In Light Of Learning Theories

    Directory of Open Access Journals (Sweden)

    Muhammad K. AFIFI

    2014-01-01

    Full Text Available The researchers conducted an exploratory study to determine the design quality of some E-courses delivered via the web to a number of colleagues at the university. Results revealed a number of shortcomings in the design of these courses, mostly due to the absence of effective principles in the design of these E-courses, especially principles of pedagogy in relation to learning theories. So, this study seeks to identify effective principles in the design of courses for internet-based learning in the light of current learning theories, by answering the following question: What are the most effective principles when designing E-learning courses in the light of current learning theories? After an extensive review and analysis of the literature and previous studies relating to quality standards for the instructional design of E-courses delivered via the web, in particular, and quality standards for E-learning, in general, the results of this study revealed a number of principles for course design in E-learning. These are: identifying learning and performance outcomes; identifying methods and strategies of learning; designing learning activities; providing feedback and motivating the learner and determining the context and impact of learning. In the light of the findings of this study, with reference to the literature, we present a set of recommendations and pedagogical implications for professionals working in course design in E-learning at University of Dammam.

  5. Enterprise mashups: Design principles towards the long tail of user needs

    OpenAIRE

    Hoyer V.; Stanoesvka-Slabeva K.; Janner T.; Schroth C.

    2008-01-01

    A new type of Web-based applications, known as Enterprise Mashups, has been gaining momentum in the last years. Novel design principles are currently about to emerge allowing to cover the long tail of user needs and to provide individual and heterogeneous enterprise applications in a shorter time. In this paper, we introduce the main components of this new paradigm, and discuss the design principles of the architecture (Enterprise Mashup Stack), upcoming intermediaries and mass collaboration,...

  6. Exploring design principles for self service technologies: The case of a ticket vending machine

    OpenAIRE

    Seim, Marius

    2014-01-01

    The principal goal of this thesis was to research self service technologies used in public spaces, and how they can be improved upon. The main research question posed for this thesis was: "How well do the existing design principles support the ongoing development of self-service systems and are they su?cient?". There were also two sub-questions posed to further explore the topic: "How can novel design principles be used to improve the usability of self-service...

  7. Designing substrates for silicene and germanene: First-principles calculations

    Science.gov (United States)

    Chen, M. X.; Zhong, Z.; Weinert, M.

    2016-08-01

    We propose a guideline for exploring substrates that stabilize the monolayer honeycomb structure of silicene and germanene while simultaneously preserving the Dirac states: in addition to having a strong binding energy to the monolayer, a suitable substrate should be a large-gap semiconductor with a proper work function such that the Dirac point lies in the gap and far from the substrate states when their bands align. We illustrate our idea by performing first-principles calculations for silicene and germanene on the Al-terminated (0001) surface of Al2O3 . The overlaid monolayers on Al-terminated Al2O3 (0001) retain the main structural profile of the low-buckled honeycomb structure via a binding energy comparable to the one between silicene and Ag(111). An unfolded band structure derived from the k -projection method reveals that a gapped Dirac cone is formed at the K point due to the structural distortion and the interaction with the substrate. The gaps of 0.4 and 0.3 eV, respectively, for the supported silicene and germanene suggest that they may have potential applications in nanoelectronics.

  8. The design principles of edutainment system for autistic children with communication difficulties

    Science.gov (United States)

    Hussain, Azham; Abdullah, Adil; Husni, Husniza

    2016-08-01

    Approximately 50% of all individuals with Autism have difficulties in developing functional language owing to communication deterioration. Mobile devices with installed educational games help these individuals feel more comfortable and relaxed doing such activities. Although numerous mobile applications are available for individuals with Autism, they are difficult to use; particularly in terms of user-interface design. From the analysis of existing apps for autistic children, an app design principles are proposed based on interaction design (IxD), that would fulfil the users' requirements in a better manner. Five applications were involved in this analysis. The analysis identified fifteen suggestions for the design principles. These recommendations are offered by this paper towards designing and developing a prototype app for autistic children. This paper introduces an edutainment-system design principle formulated to help develop the communication skills of children with Autism-spectrum disorders.

  9. Four Principles for User Interface Design of Computerised Clinical Decision Support Systems

    DEFF Research Database (Denmark)

    Kanstrup, Anne Marie; Christiansen, Marion Berg; Nøhr, Christian

    2011-01-01

    Abstract.  The paper presents results from design of a user interface for a Computerised Clinical Decision Support System (CSSS). The ambition has been to design Human-Computer Interaction that can minimise medication errors. Through an iterative design process a digital prototype for prescription...... emphasises a focus on how users interact with the system, a focus on how information is provided by the system, and four principles of interaction. The four principles for design of user interfaces for CDSS are summarised as four A’s: All in one, At a glance, At hand and Attention. It is recommended that all...... four interaction principles are integrated in the design of user interfaces for CDSS, i.e. the model is an integrated model which we suggest as a guide for interaction design when working with preventing medication errors....

  10. Design principles and realization of electro-optical circuit boards

    Science.gov (United States)

    Betschon, Felix; Lamprecht, Tobias; Halter, Markus; Beyer, Stefan; Peterson, Harry

    2013-02-01

    The manufacturing of electro-optical circuit boards (EOCB) is based to a large extent on established technologies. First products with embedded polymer waveguides are currently produced in series. The range of applications within the sensor and data communication markets is growing with the increasing maturity level. EOCBs require design flows, processes and techniques similar to existing printed circuit board (PCB) manufacturing and appropriate for optical signal transmission. A key aspect is the precise and automated assembly of active and passive optical components to the optical waveguides which has to be supported by the technology. The design flow is described after a short introduction into the build-up of EOCBs and the motivation for the usage of this technology within the different application fields. Basis for the design of EOCBs are the required optical signal transmission properties. Thereafter, the devices for the electro-optical conversion are chosen and the optical coupling approach is defined. Then, the planar optical elements (waveguides, splitters, couplers) are designed and simulated. This phase already requires co-design of the optical and electrical domain using novel design flows. The actual integration of an optical system into a PCB is shown in the last part. The optical layer is thereby laminated to the purely electrical PCB using a conventional PCB-lamination process to form the EOCB. The precise alignment of the various electrical and optical layers is thereby essential. Electrical vias are then generated, penetrating also the optical layer, to connect the individual electrical layers. Finally, the board has to be tested electrically and optically.

  11. Real-time systems design principles for distributed embedded applications

    CERN Document Server

    Kopetz, Hermann

    1997-01-01

    The book explains the relevance of recent scientific insights to the solution of everyday problems in the design and implementation of distributed and embedded real-time systems. Thus, as a reference source the book presents real-time technology in a concise and understandable manner. Because the cost-effectiveness of a particular method is of major concern in an industrial setting, design decisions are examined from an economic viewpoint. The recent appearance of cost-effective powerful system chips has tremendous influence on the architecture and economics of future distributed system soluti

  12. Zero Energy Buildings – Design Principles and Built Examples

    DEFF Research Database (Denmark)

    Bejder, Anne Kirkegaard; Knudstrup, Mary-Ann; Jensen, Rasmus Lund;

    Designing a zero energy building is a complicated task, and in order to achieve good results it is necessary to include knowledge from a range of sources. Therefore, cooperation is required between different professions and between generalists and specialists from the very beginning of the proces...

  13. MANUAL: BIOVENTING PRINCIPLES AND PRACTICE VOLUME II. BIOVENTING DESIGN

    Science.gov (United States)

    The results from bioventing research and development efforts and from the pilot-scale bioventing systems have been used to produce this two-volume manual. Although this design manual has been written based on extensive experience with petroleum hydrocarbons (and thus, many exampl...

  14. Mammalian designer cells: Engineering principles and biomedical applications.

    Science.gov (United States)

    Xie, Mingqi; Fussenegger, Martin

    2015-07-01

    Biotechnology is a widely interdisciplinary field focusing on the use of living cells or organisms to solve established problems in medicine, food production and agriculture. Synthetic biology, the science of engineering complex biological systems that do not exist in nature, continues to provide the biotechnology industry with tools, technologies and intellectual property leading to improved cellular performance. One key aspect of synthetic biology is the engineering of deliberately reprogrammed designer cells whose behavior can be controlled over time and space. This review discusses the most commonly used techniques to engineer mammalian designer cells; while control elements acting on the transcriptional and translational levels of target gene expression determine the kinetic and dynamic profiles, coupling them to a variety of extracellular stimuli permits their remote control with user-defined trigger signals. Designer mammalian cells with novel or improved biological functions not only directly improve the production efficiency during biopharmaceutical manufacturing but also open the door for cell-based treatment strategies in molecular and translational medicine. In the future, the rational combination of multiple sets of designer cells could permit the construction and regulation of higher-order systems with increased complexity, thereby enabling the molecular reprogramming of tissues, organisms or even populations with highest precision.

  15. Brownian molecular rotors: Theoretical design principles and predicted realizations

    OpenAIRE

    Schönborn, Jan Boyke; Herges, Rainer; Hartke, Bernd

    2009-01-01

    We propose simple design concepts for molecular rotors driven by Brownian motion and external photochemical switching. Unidirectionality and efficiency of the motion is measured by explicit simulations. Two different molecular scaffolds are shown to yield viable molecular rotors when decorated with suitable substituents.

  16. Five Principles for MOOC Design: With a Case Study

    Science.gov (United States)

    Drake, John R.; O'Hara, Margaret; Seeman, Elaine

    2015-01-01

    New web technologies have enabled online education to take on a massive scale, prompting many universities to create massively open online courses (MOOCs) that take advantage of these technologies in a seemingly effortless manner. Designing a MOOC, however, is anything but trivial. It involves developing content, learning activities, and…

  17. Serious game design principles: The impact of game design on learning outcomes

    Science.gov (United States)

    Martin, Michael W.

    This dissertation examines the research question "How do video game design principles affect learning outcomes in serious games?" This research first develops a theoretical foundation concerning the meaning of the terms "game" and "serious game". This conceptual clarification is broken down into analytic propositions, which state that games have participants, rules, goals and challenges, and synthetic propositions, which state that the games should be intrinsically compelling, provide meaningful choices, and be self encapsulated. Based on these synthetic propositions, three hypotheses were developed. The hypotheses are that games with an enhanced aesthetic presentation, more meaningful choices, or provide player competition will elicit higher learning outcomes than identical games without these factors. These hypotheses were tested via a quantitative experiment involving 172 undergraduate students in the Old Dominion University Chemistry Department. The students were asked to play a chemistry-oriented serious game entitled Element Solitaire©, which was created by the research author. The students were randomly given different treatments of the Element Solitaire© game to play, and the difference between their learning outcomes were compared. The experimental results demonstrated that the aesthetic presentation of a game can have a significant impact upon the learning outcome. The experiment was not able to discern significant effects from the choice or competition conditions, but further examination of the experimental data did reveal some insight into these aspects of serious game design. Choices need to provide the player with options that have a sufficient value that they will be considered and the application of competition within games needs to be judiciously implemented to promote a positive affect for all players. The results of the theoretical foundations and empirical evidence were then combined with additional theoretical research to develop a set of

  18. POOLkits: Applying Object Oriented Principles from Software Engineering to Physics Object Oriented Learning -- Preliminary Concepts

    Science.gov (United States)

    Kassebaum, Thomas; Aubrecht, Gordon

    2012-04-01

    Object-oriented development depends upon the creation of generic pieces that can be built into more complex parts. In physics, we begin teaching basic principles and then develop more complex systems, a fertile environment to develop learning objects. Each learning object consists of observable quantities, such as the physical properties of a block of wood, and operators that act on the object, such as force. Additionally, each object can also include an assessment operator that evaluates the impact of the learning object on student comprehension. The physics object-oriented learning kits (POOLkits) will be developed to enhance student understanding of physics concepts, as well as, build a framework for developing a software object based on the physics concept. A POOLkit can be extended, similar to the concept of extending classes in object-oriented programming, as physics knowledge expands. The expectation for these POOLkits would be to provide physics students with a solid foundation in the first principles to be able to derive more complex formulae and have the understanding of the process with a secondary benefit of enhancing the object-oriented programming capabilities of physics students.

  19. Fast and effective embedded systems design applying the ARM mbed

    CERN Document Server

    Toulson, Rob

    2012-01-01

    A hands-on introduction to the field of embedded systems; A focus on fast prototyping of embedded systems; All key embedded system concepts covered through simple and effective experimentation; An understanding of ARM technology, one of the world's leaders; A practical introduction to embedded C; Applies possibly the most accessible set of tools available in the embedded world.  This book is an introduction to embedded systems design, using the ARM mbed and C programming language as development tools. The mbed provides a compact, self-contained and low-cost hardware core, and the

  20. Theory and principled methods for the design of metaheuristics

    CERN Document Server

    Borenstein, Yossi

    2013-01-01

    Metaheuristics, and evolutionary algorithms in particular, are known to provide efficient, adaptable solutions for many real-world problems, but the often informal way in which they are defined and applied has led to misconceptions, and even successful applications are sometimes the outcome of trial and error. Ideally, theoretical studies should explain when and why metaheuristics work, but the challenge is huge: mathematical analysis requires significant effort even for simple scenarios and real-life problems are usually quite complex.  In this book the editors establish a bridge between theo

  1. Virtual Screening and Structure Generation Applied to Drug Design

    Institute of Scientific and Technical Information of China (English)

    FAN B.T.; CHEN H. F.; XIE L.; YUAN S. G.; A. PANAYE; J-P. DOUCET

    2004-01-01

    The methods of computer-aided drug design can be divided into two categories according to whether or not the structures of receptors are known1, corresponding to two principal strategies:(1) searching the bio-active ligands against virtual combinatorial libraries and calculating the affinity energy between ligand and receptor by docking ; (2) QSAR and 3D-structure data-mining.3D-QSAR method is now applied widely to drug discovery, but this method is generally limited to refine the structures of known bio-active compounds. During the process of drug design, we have usually the prejudice that certain groups or structural fragments will play or not important roles on the activity. This will sometimes be misleading, and prevent us from obtaining expected results.The method of generating firstly diverse structures, then screening out the promising structures by means of a computational method or QSAR model, is an efficient way for drug discovery. We developed an efficient virtual and rational drag design method. It combines virtual bioactive compound generation using genetic algorithms with 3D-QSAR model and docking. Using this method can generate a lot of highly diverse molecules and find virtual active lead compounds. The method was validated by the study on a set of anti-tumor drugs, colchicine analogs2. With the constraints of pharmacophore obtained determined by DISCO, 97 virtual bioactive compounds were generated,and their anti-tumor activities were predicted by CoMFA. 8 structures with high activity were selected and screened by 3D-QSAR model. The most active generated structure was further investigated by modifying its structure in order to increase the activity (see fig.1). This drug design method could also avoid the conflict between the insufficiency of active structures and the great quantity of compounds needed for high-throughput screening. This method has been also applied to anti-HIV drug design.We have developed equally another approach of virtual

  2. Design of Tapered Riser Using Basic Hydraulic Principles

    Directory of Open Access Journals (Sweden)

    Melody Chepkoech

    2016-06-01

    Full Text Available In sand casting, the design of gating and riser system plays an important role in the quality of the casting. Poor designs of these two parameters lead to major defects such as incomplete filling, porosity, and re-oxidation inclusions. These defects cause the castings to be susceptible to failure during their use. A riser system with high volume to surface area ratio gives a sound casting. The conventional casting setup used in many foundries incorporates the use of cylindrical risers. Improvement of the gating and riser system by use of computational analysis was carried out. Through several computational analyses, it was concluded that a casting with minimal defects could be obtained by modifying a cylindrical riser to form a tapered riser which has a higher volume to surface area ratio.

  3. Designing sensory-substitution devices: Principles, pitfalls and potential1

    Science.gov (United States)

    Kristjánsson, Árni; Moldoveanu, Alin; Jóhannesson, Ómar I.; Balan, Oana; Spagnol, Simone; Valgeirsdóttir, Vigdís Vala; Unnthorsson, Rúnar

    2016-01-01

    An exciting possibility for compensating for loss of sensory function is to augment deficient senses by conveying missing information through an intact sense. Here we present an overview of techniques that have been developed for sensory substitution (SS) for the blind, through both touch and audition, with special emphasis on the importance of training for the use of such devices, while highlighting potential pitfalls in their design. One example of a pitfall is how conveying extra information about the environment risks sensory overload. Related to this, the limits of attentional capacity make it important to focus on key information and avoid redundancies. Also, differences in processing characteristics and bandwidth between sensory systems severely constrain the information that can be conveyed. Furthermore, perception is a continuous process and does not involve a snapshot of the environment. Design of sensory substitution devices therefore requires assessment of the nature of spatiotemporal continuity for the different senses. Basic psychophysical and neuroscientific research into representations of the environment and the most effective ways of conveying information should lead to better design of sensory substitution systems. Sensory substitution devices should emphasize usability, and should not interfere with other inter- or intramodal perceptual function. Devices should be task-focused since in many cases it may be impractical to convey too many aspects of the environment. Evidence for multisensory integration in the representation of the environment suggests that researchers should not limit themselves to a single modality in their design. Finally, we recommend active training on devices, especially since it allows for externalization, where proximal sensory stimulation is attributed to a distinct exterior object. PMID:27567755

  4. Designing sensory-substitution devices: Principles, pitfalls and potential1.

    Science.gov (United States)

    Kristjánsson, Árni; Moldoveanu, Alin; Jóhannesson, Ómar I; Balan, Oana; Spagnol, Simone; Valgeirsdóttir, Vigdís Vala; Unnthorsson, Rúnar

    2016-09-21

    An exciting possibility for compensating for loss of sensory function is to augment deficient senses by conveying missing information through an intact sense. Here we present an overview of techniques that have been developed for sensory substitution (SS) for the blind, through both touch and audition, with special emphasis on the importance of training for the use of such devices, while highlighting potential pitfalls in their design. One example of a pitfall is how conveying extra information about the environment risks sensory overload. Related to this, the limits of attentional capacity make it important to focus on key information and avoid redundancies. Also, differences in processing characteristics and bandwidth between sensory systems severely constrain the information that can be conveyed. Furthermore, perception is a continuous process and does not involve a snapshot of the environment. Design of sensory substitution devices therefore requires assessment of the nature of spatiotemporal continuity for the different senses. Basic psychophysical and neuroscientific research into representations of the environment and the most effective ways of conveying information should lead to better design of sensory substitution systems. Sensory substitution devices should emphasize usability, and should not interfere with other inter- or intramodal perceptual function. Devices should be task-focused since in many cases it may be impractical to convey too many aspects of the environment. Evidence for multisensory integration in the representation of the environment suggests that researchers should not limit themselves to a single modality in their design. Finally, we recommend active training on devices, especially since it allows for externalization, where proximal sensory stimulation is attributed to a distinct exterior object. PMID:27567755

  5. Design principles for ligand-sensing, conformation-switching ribozymes.

    Directory of Open Access Journals (Sweden)

    Xi Chen

    2009-12-01

    Full Text Available Nucleic acid sensor elements are proving increasingly useful in biotechnology and biomedical applications. A number of ligand-sensing, conformational-switching ribozymes (also known as allosteric ribozymes or aptazymes have been generated by some combination of directed evolution or rational design. Such sensor elements typically fuse a molecular recognition domain (aptamer with a catalytic signal generator (ribozyme. Although the rational design of aptazymes has begun to be explored, the relationships between the thermodynamics of aptazyme conformational changes and aptazyme performance in vitro and in vivo have not been examined in a quantitative framework. We have therefore developed a quantitative and predictive model for aptazymes as biosensors in vitro and as riboswitches in vivo. In the process, we have identified key relationships (or dimensionless parameters that dictate aptazyme performance, and in consequence, established equations for precisely engineering aptazyme function. In particular, our analysis quantifies the intrinsic trade-off between ligand sensitivity and the dynamic range of activity. We were also able to determine how in vivo parameters, such as mRNA degradation rates, impact the design and function of aptazymes when used as riboswitches. Using this theoretical framework we were able to achieve quantitative agreement between our models and published data. In consequence, we are able to suggest experimental guidelines for quantitatively predicting the performance of aptazyme-based riboswitches. By identifying factors that limit the performance of previously published systems we were able to generate immediately testable hypotheses for their improvement. The robust theoretical framework and identified optimization parameters should now enable the precision design of aptazymes for biotechnological and clinical applications.

  6. Genetic algorithms applied to nuclear reactor design optimization

    International Nuclear Information System (INIS)

    A genetic algorithm is a powerful search technique that simulates natural evolution in order to fit a population of computational structures to the solution of an optimization problem. This technique presents several advantages over classical ones such as linear programming based techniques, often used in nuclear engineering optimization problems. However, genetic algorithms demand some extra computational cost. Nowadays, due to the fast computers available, the use of genetic algorithms has increased and its practical application has become a reality. In nuclear engineering there are many difficult optimization problems related to nuclear reactor design. Genetic algorithm is a suitable technique to face such kind of problems. This chapter presents applications of genetic algorithms for nuclear reactor core design optimization. A genetic algorithm has been designed to optimize the nuclear reactor cell parameters, such as array pitch, isotopic enrichment, dimensions and cells materials. Some advantages of this genetic algorithm implementation over a classical method based on linear programming are revealed through the application of both techniques to a simple optimization problem. In order to emphasize the suitability of genetic algorithms for design optimization, the technique was successfully applied to a more complex problem, where the classical method is not suitable. Results and comments about the applications are also presented. (orig.)

  7. Application of Systems Engineering Principles for Concept Design of New Products

    Science.gov (United States)

    Kumar, Karunakaran Nair Ajith; Jagathy Raj, Vettuvila Purushothaman

    2016-06-01

    A successful engineering design is one that meets the user requirements completely. Design essentially starts with concept design followed by detailed design. The importance of concept design is brought out in this paper. Systems engineering principles and practices are used to build the concept design starting from user requirements and user specified reference scenarios. Systems engineering methodology helps in proper understanding of the user requirements, identifying multiple solutions, short listing the candidate solutions and finally selecting one or two feasible designs. A case study analysis is presented to demonstrate the systems engineering practices followed for concept abstraction and preliminary design of a typical engineering system.

  8. Software engineering principles applied to large healthcare information systems--a case report.

    Science.gov (United States)

    Nardon, Fabiane Bizinella; de A Moura, Lincoln

    2007-01-01

    São Paulo is the largest city in Brazil and one of the largest cities in the world. In 2004, São Paulo City Department of Health decided to implement a Healthcare Information System to support managing healthcare services and provide an ambulatory health record. The resulting information system is one of the largest public healthcare information systems ever built, with more than 2 million lines of code. Although statistics shows that most software projects fail, and the risks for the São Paulo initiative were enormous, the information system was completed on-time and on-budget. In this paper, we discuss the software engineering principles adopted that allowed to accomplish that project's goals, hoping that sharing the experience of this project will help other healthcare information systems initiatives to succeed.

  9. Future Research in Agile Systems Development: Applying Open Innovation Principles Within the Agile Organisation

    Science.gov (United States)

    Conboy, Kieran; Morgan, Lorraine

    A particular strength of agile approaches is that they move away from ‘introverted' development and intimately involve the customer in all areas of development, supposedly leading to the development of a more innovative and hence more valuable information system. However, we argue that a single customer representative is too narrow a focus to adopt and that involvement of stakeholders beyond the software development itself is still often quite weak and in some cases non-existent. In response, we argue that current thinking regarding innovation in agile development needs to be extended to include multiple stakeholders outside the business unit. This paper explores the intra-organisational applicability and implications of open innovation in agile systems development. Additionally, it argues for a different perspective of project management that includes collaboration and knowledge-sharing with other business units, customers, partners, and other relevant stakeholders pertinent to the business success of an organisation, thus embracing open innovation principles.

  10. Forensic engineering: applying materials and mechanics principles to the investigation of product failures.

    Science.gov (United States)

    Hainsworth, S V; Fitzpatrick, M E

    2007-06-01

    Forensic engineering is the application of engineering principles or techniques to the investigation of materials, products, structures or components that fail or do not perform as intended. In particular, forensic engineering can involve providing solutions to forensic problems by the application of engineering science. A criminal aspect may be involved in the investigation but often the problems are related to negligence, breach of contract, or providing information needed in the redesign of a product to eliminate future failures. Forensic engineering may include the investigation of the physical causes of accidents or other sources of claims and litigation (for example, patent disputes). It involves the preparation of technical engineering reports, and may require giving testimony and providing advice to assist in the resolution of disputes affecting life or property.This paper reviews the principal methods available for the analysis of failed components and then gives examples of different component failure modes through selected case studies.

  11. Real-time embedded systems design principles and engineering practices

    CERN Document Server

    Fan, Xiaocong

    2015-01-01

    This book integrates new ideas and topics from real time systems, embedded systems, and software engineering to give a complete picture of the whole process of developing software for real-time embedded applications. You will not only gain a thorough understanding of concepts related to microprocessors, interrupts, and system boot process, appreciating the importance of real-time modeling and scheduling, but you will also learn software engineering practices such as model documentation, model analysis, design patterns, and standard conformance. This book is split into four parts to help you

  12. Designing Embedded Systems with PIC Microcontrollers Principles and Applications

    CERN Document Server

    Wilmshurst, Tim

    2009-01-01

    PIC microcontrollers are used worldwide in commercial and industrial devices. The 8-bit PIC which this book focuses on is a versatile work horse that completes many designs. An engineer working with applications that include a microcontroller will no doubt come across the PIC sooner rather than later. It is a must to have a working knowledge of this 8-bit technology. This book takes the novice from introduction of embedded systems through to advanced development techniques for utilizing and optimizing the PIC family of microcontrollers in your device. To truly understand the PIC, assembly and

  13. Design and Characterization of Photoelectrodes from First Principles

    Energy Technology Data Exchange (ETDEWEB)

    Ogitsu, T; Wood, B; Choi, W; Huda, M; Wei, S

    2012-05-11

    Although significant performance improvements have been realized since the first demonstration of sunlight-driven water splitting in 1972, mainstream adoption of photoelectrochemical (PEC) cells remains limited by an absence of cost-effective electrodes that show simultaneously high conversion efficiency and good durability. Here we outline current and future efforts to use advanced theoretical techniques to guide the development of a durable, high-performance PEC electrode material. Working in close collaboration with experimental synthesis and characterization teams, we use a twofold approach focusing on: (1) rational design of novel high-performance electrode materials; and (2) characterization and optimization of the electrode-electrolyte interface.

  14. Three Principles for the Design of Energy Feedback Visualizations

    DEFF Research Database (Denmark)

    Brewer, Robert S.; Xu, Yongwen; Lee, George E.;

    2013-01-01

    To achieve the full benefits of the Smart Grid, end users must become active participants in the energy ecosystem. This paper presents the Kukui Cup challenge, a multifaceted serious game designed around the topic of energy conservation that incorporates a variety of energy feedback visualizations...... address these three factors: 1) they should be actionable, 2) domain knowledge should go hand in hand with feedback systems, and 3) feedback must be "sticky" if it is to lead to changes in behaviors and attitudes. We provide examples of both successful and unsuccessful visualizations, and discuss how...

  15. Primate Anatomy, Kinematics, and Principles for Humanoid Design

    Science.gov (United States)

    Ambrose, Robert O.; Ambrose, Catherine G.

    2004-01-01

    The primate order of animals is investigated for clues in the design of Humanoid Robots. The pursuit is directed with a theory that kinematics, musculature, perception, and cognition can be optimized for specific tasks by varying the proportions of limbs, and in particular, the points of branching in kinematic trees such as the primate skeleton. Called the Bifurcated Chain Hypothesis, the theory is that the branching proportions found in humans may be superior to other animals and primates for the tasks of dexterous manipulation and other human specialties. The primate taxa are defined, contemporary primate evolution hypotheses are critiqued, and variations within the order are noted. The kinematic branching points of the torso, limbs and fingers are studied for differences in proportions across the order, and associated with family and genus capabilities and behaviors. The human configuration of a long waist, long neck, and short arms is graded using a kinematic workspace analysis and a set of design axioms for mobile manipulation robots. It scores well. The re emergence of the human waist, seen in early Prosimians and Monkeys for arboreal balance, but lost in the terrestrial Pongidae, is postulated as benefiting human dexterity. The human combination of an articulated waist and neck will be shown to enable the use of smaller arms, achieving greater regions of workspace dexterity than the larger limbs of Gorillas and other Hominoidea.

  16. Medicinal chemistry design principles for liver targeting through OATP transporters.

    Science.gov (United States)

    Tu, Meihua; Mathiowetz, Alan M; Pfefferkorn, Jeffrey A; Cameron, Kimberly O; Dow, Robert L; Litchfield, John; Di, Li; Feng, Bo; Liras, Spiros

    2013-01-01

    The tissue distribution of a drug can have significant impact on both its efficacy and safety. As a consequence, selective tissue targeting has become an attractive approach for optimizing the window between efficacy and safety for drug targets that are ubiquitously expressed and important in key physiological processes. Given the liver's key role in metabolic regulation and the fact that it is the principal tissue affected by diseases such as hepatitis B and C viruses as well as hepatocellular carcinoma, designing drugs with hepatoselective distribution profiles is an important strategy in developing safe cardiovascular, metabolic, antiviral and oncology drug candidates. In this paper, we analyze a diverse set of compounds from four different projects within Pfizer that specifically pursued liver targeting strategies. A number of key in vitro and in vivo ADME endpoints were collected including in vivo tissue exposure, oral bioavailability, clearance in preclinical species and in vitro hepatic OATP uptake, in vitro rat liver microsomal stability, permeability, solubility, logD, and others. From this analysis, we determined a set of general structure-liver-selectivity guides for designing orally bioavailable, liver-targeted candidates using liver specific OATP transporters. The guidelines have been formulated using straightforward molecular descriptors and in vitro properties that medicinal chemists routinely optimize. Our analysis emphasizes the need to focus on a chemical space with balanced lipophilicity, high aqueous solubility and low passive permeability in order to achieve the desired hepatoselectivity while maintaining fraction absorbed.

  17. Experimental Reality: Principles for the Design of Augmented Environments

    Science.gov (United States)

    Lahlou, Saadi

    The Laboratory of Design for Cognition at EDF R&D (LDC) is a living laboratory, which we created to develop Augmented Environment (AE) for collaborative work, more specifically “cognitive work” (white collars, engineers, office workers). It is a corporate laboratory in a large industry, where natural activity of real users is observed in a continuous manner in various spaces (project space, meeting room, lounge, etc.) The RAO room, an augmented meeting room, is used daily for “normal” meetings; it is also the “mother room” of all augmented meeting rooms in the company, where new systems, services, and devices are tested. The LDC has gathered a unique set of data on the use of AE, and developed various observation and design techniques, described in this chapter. LDC uses novel techniques of digital ethnography, some of which were invented there (SubCam, offsat) and some of which were developed elsewhere and adapted (360° video, WebDiver, etc.). At LDC, some new theories have also been developed to explain behavior and guide innovation: cognitive attractors, experimental reality, and the triple-determination framework.

  18. Sociosexuality Education for Persons with Autism Spectrum Disorders Using Principles of Applied Behavior Analysis

    Science.gov (United States)

    Wolfe, Pamela S.; Condo, Bethany; Hardaway, Emily

    2009-01-01

    Applied behavior analysis (ABA) has emerged as one of the most effective empirically based strategies for instructing individuals with autism spectrum disorders (ASD). Four ABA-based strategies that have been found effective are video modeling, visual strategies, social script fading, and task analysis. Individuals with ASD often struggle with…

  19. A Self-Administered Parent Training Program Based upon the Principles of Applied Behavior Analysis

    Science.gov (United States)

    Maguire, Heather M.

    2012-01-01

    Parents often respond to challenging behavior exhibited by their children in such a way that unintentionally strengthens it. Applied behavior analysis (ABA) is a research-based science that has been proven effective in remediating challenging behavior in children. Although many parents could benefit from using strategies from the field of ABA with…

  20. Students as Employees: Applying Performance Management Principles in the Management Classroom

    Science.gov (United States)

    Gillespie, Treena L.; Parry, Richard O.

    2009-01-01

    The student-as-employee metaphor emphasizes student accountability and participation in learning and provides instructors with work-oriented methods for creating a productive class environment. The authors propose that the tenets of performance management in work organizations can be applied to the classroom. In particular, they focus on three…

  1. 29 CFR 779.101 - Guiding principles for applying coverage and exemption provisions.

    Science.gov (United States)

    2010-07-01

    ... to be broad in its scope. “Breadth of coverage is vital to its mission.” (Powell v. U.S. Cartridge Co... applies. (Walling v. General Industries Co., 330 U.S. 545; Mitchell v. Kentucky Finance Co., 359 U.S. 290..., 324 U.S. 490; Mitchell v. Kentucky Finance Co., supra; Arnold v. Kanowsky, supra; Calaf v....

  2. 29 CFR 783.21 - Guiding principles for applying coverage and exemption provisions.

    Science.gov (United States)

    2010-07-01

    .... v. Walling, 132 F. 2d 616). “Breadth of coverage is vital to its mission” (Powell v. U.S. Cartridge... it applies (Walling v. General Industries Co., 330 U.S. 545; Mitchell v. Kentucky Finance Co., 359 U.S. 290; Tobin v. Blue Channel Corp. 198 F. 2d 245, approved in Mitchell v. Myrtle Grove Packing...

  3. On the importance of agile communication skills in BPM education: Design principles for international seminars

    Directory of Open Access Journals (Sweden)

    Jan vom Brocke

    2012-12-01

    Full Text Available Business Process Management (BPM has evolved as an integrated management discipline that aims to enable organizations to continuously innovate and improve their operations. BPM experts are exposed to communication processes involving people from various backgrounds (e.g., various business areas, fields of expertise, and cultures. Research in applied linguistics has shown that it is difficult to plan for constellations of such communication processes; thus, agile communication skills are vital for successful business communication. Teaching programs for BPM, however, do not account for these skills. Rather, they mainly address methods for the analysis, implementation, and management of business processes. As a result, graduates—though they may be technically and methodologically apt—face unexpected challenges due to communication deficiencies in BPM projects. BPM research has shown that deficiencies in communication are in fact among the most frequent reasons for project failure. In this paper, we present a course setting to teach agile communication skills in BPM education. The approach is informed by literature on BPM education as well as theories from virtual collaboration education. We have evaluated it in an international virtual seminar involving seven European universities. We argue for the importance of agile communication skills in BPM education. In addition, we present design principles for courses to teach agile communication skills that can be applied by fellow academics.

  4. Design principles of the yeast G1/S switch.

    Directory of Open Access Journals (Sweden)

    Xiaojing Yang

    2013-10-01

    Full Text Available A hallmark of the G1/S transition in budding yeast cell cycle is the proteolytic degradation of the B-type cyclin-Cdk stoichiometric inhibitor Sic1. Deleting SIC1 or altering Sic1 degradation dynamics increases genomic instability. Certain key facts about the parts of the G1/S circuitry are established: phosphorylation of Sic1 on multiple sites is necessary for its destruction, and both the upstream kinase Cln1/2-Cdk1 and the downstream kinase Clb5/6-Cdk1 can phosphorylate Sic1 in vitro with varied specificity, cooperativity, and processivity. However, how the system works as a whole is still controversial due to discrepancies between in vitro, in vivo, and theoretical studies. Here, by monitoring Sic1 destruction in real time in individual cells under various perturbations to the system, we provide a clear picture of how the circuitry functions as a switch in vivo. We show that Cln1/2-Cdk1 sets the proper timing of Sic1 destruction, but does not contribute to its destruction speed; thus, it acts only as a trigger. Sic1's inhibition target Clb5/6-Cdk1 controls the speed of Sic1 destruction through a double-negative feedback loop, ensuring a robust all-or-none transition for Clb5/6-Cdk1 activity. Furthermore, we demonstrate that the degradation of a single-phosphosite mutant of Sic1 is rapid and switch-like, just as the wild-type form. Our mathematical model confirms our understanding of the circuit and demonstrates that the substrate sharing between the two kinases is not a redundancy but a part of the design to overcome the trade-off between the timing and sharpness of Sic1 degradation. Our study provides direct mechanistic insight into the design features underlying the yeast G1/S switch.

  5. The fern cavitation catapult: mechanism and design principles.

    Science.gov (United States)

    Llorens, C; Argentina, M; Rojas, N; Westbrook, J; Dumais, J; Noblin, X

    2016-01-01

    Leptosporangiate ferns have evolved an ingenious cavitation catapult to disperse their spores. The mechanism relies almost entirely on the annulus, a row of 12-25 cells, which successively: (i) stores energy by evaporation of the cells' content, (ii) triggers the catapult by internal cavitation, and (iii) controls the time scales of energy release to ensure efficient spore ejection. The confluence of these three biomechanical functions within the confines of a single structure suggests a level of sophistication that goes beyond most man-made devices where specific structures or parts rarely serve more than one function. Here, we study in detail the three phases of spore ejection in the sporangia of the fern Polypodium aureum. For each of these phases, we have written the governing equations and measured the key parameters. For the opening of the sporangium, we show that the structural design of the annulus is particularly well suited to inducing bending deformations in response to osmotic volume changes. Moreover, the measured parameters for the osmoelastic design lead to a near-optimal speed of spore ejection (approx. 10 m s(-1)). Our analysis of the trigger mechanism by cavitation points to a critical cavitation pressure of approximately -100 ± 14 bar, a value that matches the most negative pressures recorded in the xylem of plants. Finally, using high-speed imaging, we elucidated the physics leading to the sharp separation of time scales (30 versus 5000 µs) in the closing dynamics. Our results highlight the importance of the precise tuning of the parameters without which the function of the leptosporangium as a catapult would be severely compromised.

  6. The fern cavitation catapult: mechanism and design principles.

    Science.gov (United States)

    Llorens, C; Argentina, M; Rojas, N; Westbrook, J; Dumais, J; Noblin, X

    2016-01-01

    Leptosporangiate ferns have evolved an ingenious cavitation catapult to disperse their spores. The mechanism relies almost entirely on the annulus, a row of 12-25 cells, which successively: (i) stores energy by evaporation of the cells' content, (ii) triggers the catapult by internal cavitation, and (iii) controls the time scales of energy release to ensure efficient spore ejection. The confluence of these three biomechanical functions within the confines of a single structure suggests a level of sophistication that goes beyond most man-made devices where specific structures or parts rarely serve more than one function. Here, we study in detail the three phases of spore ejection in the sporangia of the fern Polypodium aureum. For each of these phases, we have written the governing equations and measured the key parameters. For the opening of the sporangium, we show that the structural design of the annulus is particularly well suited to inducing bending deformations in response to osmotic volume changes. Moreover, the measured parameters for the osmoelastic design lead to a near-optimal speed of spore ejection (approx. 10 m s(-1)). Our analysis of the trigger mechanism by cavitation points to a critical cavitation pressure of approximately -100 ± 14 bar, a value that matches the most negative pressures recorded in the xylem of plants. Finally, using high-speed imaging, we elucidated the physics leading to the sharp separation of time scales (30 versus 5000 µs) in the closing dynamics. Our results highlight the importance of the precise tuning of the parameters without which the function of the leptosporangium as a catapult would be severely compromised. PMID:26763327

  7. Wavelet Domain Radiofrequency Pulse Design Applied to Magnetic Resonance Imaging.

    Directory of Open Access Journals (Sweden)

    Andrew M Huettner

    Full Text Available A new method for designing radiofrequency (RF pulses with numerical optimization in the wavelet domain is presented. Numerical optimization may yield solutions that might otherwise have not been discovered with analytic techniques alone. Further, processing in the wavelet domain reduces the number of unknowns through compression properties inherent in wavelet transforms, providing a more tractable optimization problem. This algorithm is demonstrated with simultaneous multi-slice (SMS spin echo refocusing pulses because reduced peak RF power is necessary for SMS diffusion imaging with high acceleration factors. An iterative, nonlinear, constrained numerical minimization algorithm was developed to generate an optimized RF pulse waveform. Wavelet domain coefficients were modulated while iteratively running a Bloch equation simulator to generate the intermediate slice profile of the net magnetization. The algorithm minimizes the L2-norm of the slice profile with additional terms to penalize rejection band ripple and maximize the net transverse magnetization across each slice. Simulations and human brain imaging were used to demonstrate a new RF pulse design that yields an optimized slice profile and reduced peak energy deposition when applied to a multiband single-shot echo planar diffusion acquisition. This method may be used to optimize factors such as magnitude and phase spectral profiles and peak RF pulse power for multiband simultaneous multi-slice (SMS acquisitions. Wavelet-based RF pulse optimization provides a useful design method to achieve a pulse waveform with beneficial amplitude reduction while preserving appropriate magnetization response for magnetic resonance imaging.

  8. Wavelet Domain Radiofrequency Pulse Design Applied to Magnetic Resonance Imaging.

    Science.gov (United States)

    Huettner, Andrew M; Mickevicius, Nikolai J; Ersoz, Ali; Koch, Kevin M; Muftuler, L Tugan; Nencka, Andrew S

    2015-01-01

    A new method for designing radiofrequency (RF) pulses with numerical optimization in the wavelet domain is presented. Numerical optimization may yield solutions that might otherwise have not been discovered with analytic techniques alone. Further, processing in the wavelet domain reduces the number of unknowns through compression properties inherent in wavelet transforms, providing a more tractable optimization problem. This algorithm is demonstrated with simultaneous multi-slice (SMS) spin echo refocusing pulses because reduced peak RF power is necessary for SMS diffusion imaging with high acceleration factors. An iterative, nonlinear, constrained numerical minimization algorithm was developed to generate an optimized RF pulse waveform. Wavelet domain coefficients were modulated while iteratively running a Bloch equation simulator to generate the intermediate slice profile of the net magnetization. The algorithm minimizes the L2-norm of the slice profile with additional terms to penalize rejection band ripple and maximize the net transverse magnetization across each slice. Simulations and human brain imaging were used to demonstrate a new RF pulse design that yields an optimized slice profile and reduced peak energy deposition when applied to a multiband single-shot echo planar diffusion acquisition. This method may be used to optimize factors such as magnitude and phase spectral profiles and peak RF pulse power for multiband simultaneous multi-slice (SMS) acquisitions. Wavelet-based RF pulse optimization provides a useful design method to achieve a pulse waveform with beneficial amplitude reduction while preserving appropriate magnetization response for magnetic resonance imaging. PMID:26517262

  9. An introduction to quantum chemical methods applied to drug design.

    Science.gov (United States)

    Stenta, Marco; Dal Peraro, Matteo

    2011-06-01

    The advent of molecular medicine allowed identifying the malfunctioning of subcellular processes as the source of many diseases. Since then, drugs are not only discovered, but actually designed to fulfill a precise task. Modern computational techniques, based on molecular modeling, play a relevant role both in target identification and drug lead development. By flanking and integrating standard experimental techniques, modeling has proven itself as a powerful tool across the drug design process. The success of computational methods depends on a balance between cost (computation time) and accuracy. Thus, the integration of innovative theories and more powerful hardware architectures allows molecular modeling to be used as a reliable tool for rationalizing the results of experiments and accelerating the development of new drug design strategies. We present an overview of the most common quantum chemistry computational approaches, providing for each one a general theoretical introduction to highlight limitations and strong points. We then discuss recent developments in software and hardware resources, which have allowed state-of-the-art of computational quantum chemistry to be applied to drug development.

  10. Design Principles of Perovskites for Thermochemical Oxygen Separation.

    Science.gov (United States)

    Ezbiri, Miriam; Allen, Kyle M; Gàlvez, Maria E; Michalsky, Ronald; Steinfeld, Aldo

    2015-06-01

    Separation and concentration of O2 from gas mixtures is central to several sustainable energy technologies, such as solar-driven synthesis of liquid hydrocarbon fuels from CO2 , H2 O, and concentrated sunlight. We introduce a rationale for designing metal oxide redox materials for oxygen separation through "thermochemical pumping" of O2 against a pO2 gradient with low-grade process heat. Electronic structure calculations show that the activity of O vacancies in metal oxides pinpoints the ideal oxygen exchange capacity of perovskites. Thermogravimetric analysis and high-temperature X-ray diffraction for SrCoO3-δ , BaCoO3-δ and BaMnO3-δ perovskites and Ag2 O and Cu2 O references confirm the predicted performance of SrCoO3-δ , which surpasses the performance of state-of-the-art Cu2 O at these conditions with an oxygen exchange capacity of 44 mmol O 2 mol SrCoO 3-δ(-1) exchanged at 12.1 μmol O 2 min(-1)  g(-1) at 600-900 K. The redox trends are understood due to lattice expansion and electronic charge transfer. PMID:25925955

  11. Design Principles of Perovskites for Thermochemical Oxygen Separation.

    Science.gov (United States)

    Ezbiri, Miriam; Allen, Kyle M; Gàlvez, Maria E; Michalsky, Ronald; Steinfeld, Aldo

    2015-06-01

    Separation and concentration of O2 from gas mixtures is central to several sustainable energy technologies, such as solar-driven synthesis of liquid hydrocarbon fuels from CO2 , H2 O, and concentrated sunlight. We introduce a rationale for designing metal oxide redox materials for oxygen separation through "thermochemical pumping" of O2 against a pO2 gradient with low-grade process heat. Electronic structure calculations show that the activity of O vacancies in metal oxides pinpoints the ideal oxygen exchange capacity of perovskites. Thermogravimetric analysis and high-temperature X-ray diffraction for SrCoO3-δ , BaCoO3-δ and BaMnO3-δ perovskites and Ag2 O and Cu2 O references confirm the predicted performance of SrCoO3-δ , which surpasses the performance of state-of-the-art Cu2 O at these conditions with an oxygen exchange capacity of 44 mmol O 2 mol SrCoO 3-δ(-1) exchanged at 12.1 μmol O 2 min(-1)  g(-1) at 600-900 K. The redox trends are understood due to lattice expansion and electronic charge transfer.

  12. Designing a Community of Practice: Principles and Practices of the GIsML Community.

    Science.gov (United States)

    Palincsar, AnneMarie Sullivan; Magnusson, Shirley J.; Marano, Nancy; Ford, Danielle; Brown, Nancy

    1998-01-01

    Describes an elementary-level professional-development project designed to build a community of practice focused on inquiry-based science teaching (Guided Inquiry supporting Multiple Literacies). Presents the basic tenets that guided the development of learning experiences for teachers and illustrates how the principles influenced the design of…

  13. 49 CFR 236.5 - Design of control circuits on closed circuit principle.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Design of control circuits on closed circuit..., AND APPLIANCES Rules and Instructions: All Systems General § 236.5 Design of control circuits on closed circuit principle. All control circuits the functioning of which affects safety of train...

  14. Designing Crop Simulation Web Service with Service Oriented Architecture Principle

    Science.gov (United States)

    Chinnachodteeranun, R.; Hung, N. D.; Honda, K.

    2015-12-01

    Crop simulation models are efficient tools for simulating crop growth processes and yield. Running crop models requires data from various sources as well as time-consuming data processing, such as data quality checking and data formatting, before those data can be inputted to the model. It makes the use of crop modeling limited only to crop modelers. We aim to make running crop models convenient for various users so that the utilization of crop models will be expanded, which will directly improve agricultural applications. As the first step, we had developed a prototype that runs DSSAT on Web called as Tomorrow's Rice (v. 1). It predicts rice yields based on a planting date, rice's variety and soil characteristics using DSSAT crop model. A user only needs to select a planting location on the Web GUI then the system queried historical weather data from available sources and expected yield is returned. Currently, we are working on weather data connection via Sensor Observation Service (SOS) interface defined by Open Geospatial Consortium (OGC). Weather data can be automatically connected to a weather generator for generating weather scenarios for running the crop model. In order to expand these services further, we are designing a web service framework consisting of layers of web services to support compositions and executions for running crop simulations. This framework allows a third party application to call and cascade each service as it needs for data preparation and running DSSAT model using a dynamic web service mechanism. The framework has a module to manage data format conversion, which means users do not need to spend their time curating the data inputs. Dynamic linking of data sources and services are implemented using the Service Component Architecture (SCA). This agriculture web service platform demonstrates interoperability of weather data using SOS interface, convenient connections between weather data sources and weather generator, and connecting

  15. Applying cognitive neuropsychological principles to the rehabilitation of Spanish readers with acquired dyslexia.

    Science.gov (United States)

    Cuetos, Fernando; Centeno, José G

    2009-08-01

    Cognitive neuropsychological models (CNMs) have been useful to generate a theory of aphasia rehabilitation. In contrast to the traditional syndrome approach, CNMs employ cognitive accounts to interpret language disturbances after brain damage. In this article, we apply CNMs to monolingual Spanish and bilingual Spanish-English readers with acquired dyslexia whose first language is Spanish. Although there are many studies of acquired dyslexia (reading errors associated with aphasia), they primarily have focused on English and French readers. Similar investigations on Spanish readers are limited. Unlike the opaque orthographic systems of English and French (inconsistent grapheme-to-phoneme relationships), Spanish has a mostly transparent orthography (regular grapheme-to-phoneme relationships). Thus evaluating and treating dyslexia secondary to brain damage in Spanish readers may involve different strategies from those employed with English and French readers. The increasingly large numbers of Spanish speakers in aphasia rehabilitation worldwide underscore the critical need to develop plausible theoretically grounded clinical strategies to serve these individuals.

  16. Physical chemistry research for engineering and applied sciences, v.1 principles and technological implications

    CERN Document Server

    Pearce, Eli M; Pethrick, Richard A

    2015-01-01

    PrefaceBacterial Poly(3-Hydroxybutyrate) as a Biodegradable Polymer for Biomedicine; A. L. Iordanskii, G. A. Bonartseva, T. A. Makhina, E. D. Sklyanchuk, and G. E. ZaikovThe Effect of Antioxidant Drug Mexidol on Bioenergetic Processes and Nitric Oxide Formation in the Animal Tissues; Z. V. Kuropteva, O. L. Belaya, L. M. Baider, and T. N. BogatyrenkoCalcium Soap Lubricants; Alazizer, Tugce Nefise Kahyaoglu, and Devrim BalköseRadical Scavenging Capacity of N-(2-Mercapto-2-Methylpropionyl)-L-Cysteine: Design and Synthesis of Its Derivative with

  17. E-learning Materials Development: Applying and Implementing Software Reuse Principles and Granularity Levels in the Small

    Directory of Open Access Journals (Sweden)

    Nabil Arman

    2010-06-01

    Full Text Available E-learning materials development is typically acknowledged as an expensive, complicated, and lengthy process, often producing materials that are of low quality and difficult to adaptand maintain. It has always been a challenge to identify proper e-learning materials that can be reused at a reasonable cost and effort. In this paper, software engineering reuse principlesare applied to e-learning materials development process. These principles are then applied and implemented in a prototype that is integrated with an open-source course management systems. The reuse of existing e-learning materials is beneficial in improving developers of elearning materials productivity. E-learning material reuse is performed, in this research, based on construct’s granularity rather than on unified constructs of one size.

  18. Recycling industrial architecture : the redefinition of the recycling principles in the context of sustainable architectural design

    OpenAIRE

    Šijaković, Milan

    2015-01-01

    The aim of this thesis is the elucidation of the concept of architectural recycling as an environmentally sustainable alternative to demolition and preservation. More precisely, the research aim relates to the redefinition of recycling design principles in the context of the sustainable architectural design. The process of architectural recycling was placed in the context of a sustainable architectural design, as the global concept of sustainable development is imposed as a general context fo...

  19. Pacific Canada's Rockfish Conservation Areas: using Ostrom's design principles to assess management effectiveness

    Directory of Open Access Journals (Sweden)

    Darienne Lancaster

    2015-09-01

    Full Text Available International declines in marine biodiversity have lead to the creation of marine protected areas and fishery reserve systems. In Canada, 164 Rockfish Conservation Areas (RCAs were implemented between 2003 and 2007 and now cover 4847.2 km² of ocean. These reserves were created in response to widespread concern from fishers and nongovernmental organizations about inshore rockfish (genus Sebastes population declines. We used the design principles for effective common-pool resource management systems, originally developed by Elinor Ostrom, to assess the social and ecological effectiveness of these conservation areas more than 10 years after their initial implementation. We assessed the relative presence or absence of each design principle within current RCA management. We found that 2 of the 11 design principles were moderately present in the recreational fishery. All other design principles were lacking for the recreational sector. We found that 2 design principles were fully present and 5 were moderately present in the commercial sector. Four design principles were lacking in the commercial sector. Based on this analysis, we highlight 4 main areas for management improvement: (1 create an education and outreach campaign to explain RCA rules, regulations, boundaries, and the need for marine conservation; (2 increase monitoring of users and resources to discourage noncompliance and gather the necessary data to create social buy-in for marine conservation; (3 encourage informal nested governance through stakeholder organizations for education and self-regulation (e.g. fisher to fisher; and (4 most importantly, create a formal, decadal RCA review process to gather stakeholder input and make amendments to regulations and RCA boundaries. This information can be used to inform spatial management systems both in Canada and internationally. This analysis also contributes to a growing literature on effectively scaling up small-scale management techniques

  20. Principles underlying the design of "The Number Race", an adaptive computer game for remediation of dyscalculia

    Directory of Open Access Journals (Sweden)

    Cohen Laurent

    2006-05-01

    Full Text Available Abstract Background Adaptive game software has been successful in remediation of dyslexia. Here we describe the cognitive and algorithmic principles underlying the development of similar software for dyscalculia. Our software is based on current understanding of the cerebral representation of number and the hypotheses that dyscalculia is due to a "core deficit" in number sense or in the link between number sense and symbolic number representations. Methods "The Number Race" software trains children on an entertaining numerical comparison task, by presenting problems adapted to the performance level of the individual child. We report full mathematical specifications of the algorithm used, which relies on an internal model of the child's knowledge in a multidimensional "learning space" consisting of three difficulty dimensions: numerical distance, response deadline, and conceptual complexity (from non-symbolic numerosity processing to increasingly complex symbolic operations. Results The performance of the software was evaluated both by mathematical simulations and by five weeks of use by nine children with mathematical learning difficulties. The results indicate that the software adapts well to varying levels of initial knowledge and learning speeds. Feedback from children, parents and teachers was positive. A companion article 1 describes the evolution of number sense and arithmetic scores before and after training. Conclusion The software, open-source and freely available online, is designed for learning disabled children aged 5–8, and may also be useful for general instruction of normal preschool children. The learning algorithm reported is highly general, and may be applied in other domains.

  1. The Principles of Conservation and Development: Do They Apply in Malinau?

    Directory of Open Access Journals (Sweden)

    Patrice Levang

    2007-12-01

    Full Text Available Attempts to reconcile economic development with environmental conservation in a forest area in East Kalimantan, Indonesia, are reviewed for the district of Malinau, East Kalimantan, Indonesia, an area of 42,000 km2 that is still largely covered in rainforest. The history of the region is described and the conservation and development impacts of external drivers of change are assessed. Both government and conservation organizations have subscribed to the rhetoric of pursuing development pathways that would be sustainable and would conserve the rich biodiversity of the area. Three distinct approaches to conservation have been attempted. First spatial planning has been used to attribute land to different uses and particularly to identify and designate protected areas. Second, measures have been taken to lessen the negative environmental impact of industrial logging and to promote the preservation of biodiversity in logged forests. Last, decentralized and community-based management has been promoted on the assumption that this would yield better environmental and social outcomes than large-scale industrial development. These conservation measures have been pursued during a period when the governance of the region has been weak. Corruption, political collusion, and nepotism have been major factors in decision making about natural resources. We argue that a sustainable future for the district of Malinau must lie in finding an appropriate balance between protected areas, forests managed at both industrial and community scales, and land conversion. However, there is little empirical evidence that allows the outcomes of these approaches to be measured. The problem of knowing how conservation investments can be made in ways that optimize sustainable benefits to local livelihoods remains largely unresolved. A number of possible conservation and development pathways for the district are discussed.

  2. Above the cloud computing: applying cloud computing principles to create an orbital services model

    Science.gov (United States)

    Straub, Jeremy; Mohammad, Atif; Berk, Josh; Nervold, Anders K.

    2013-05-01

    Large satellites and exquisite planetary missions are generally self-contained. They have, onboard, all of the computational, communications and other capabilities required to perform their designated functions. Because of this, the satellite or spacecraft carries hardware that may be utilized only a fraction of the time; however, the full cost of development and launch are still bone by the program. Small satellites do not have this luxury. Due to mass and volume constraints, they cannot afford to carry numerous pieces of barely utilized equipment or large antennas. This paper proposes a cloud-computing model for exposing satellite services in an orbital environment. Under this approach, each satellite with available capabilities broadcasts a service description for each service that it can provide (e.g., general computing capacity, DSP capabilities, specialized sensing capabilities, transmission capabilities, etc.) and its orbital elements. Consumer spacecraft retain a cache of service providers and select one utilizing decision making heuristics (e.g., suitability of performance, opportunity to transmit instructions and receive results - based on the orbits of the two craft). The two craft negotiate service provisioning (e.g., when the service can be available and for how long) based on the operating rules prioritizing use of (and allowing access to) the service on the service provider craft, based on the credentials of the consumer. Service description, negotiation and sample service performance protocols are presented. The required components of each consumer or provider spacecraft are reviewed. These include fully autonomous control capabilities (for provider craft), a lightweight orbit determination routine (to determine when consumer and provider craft can see each other and, possibly, pointing requirements for craft with directional antennas) and an authentication and resource utilization priority-based access decision making subsystem (for provider craft

  3. A design principle underlying the paradoxical roles of E3 ubiquitin ligases

    Science.gov (United States)

    Lee, Daewon; Kim, Minjin; Cho, Kwang-Hyun

    2014-07-01

    E3 ubiquitin ligases are important cellular components that determine the specificity of proteolysis in the ubiquitin-proteasome system. However, an increasing number of studies have indicated that E3 ubiquitin ligases also participate in transcription. Intrigued by the apparently paradoxical functions of E3 ubiquitin ligases in both proteolysis and transcriptional activation, we investigated the underlying design principles using mathematical modeling. We found that the antagonistic functions integrated in E3 ubiquitin ligases can prevent any undesirable sustained activation of downstream genes when E3 ubiquitin ligases are destabilized by unexpected perturbations. Interestingly, this design principle of the system is similar to the operational principle of a safety interlock device in engineering systems, which prevents a system from abnormal operation unless stability is guaranteed.

  4. Applying Learner-Centered Principles to Teaching Human Behavior in the Social Environment in a Baccalaureate Program

    Science.gov (United States)

    Karolich, Robert; Ford, Janet

    2013-01-01

    Changes in the demographics of American undergraduate students must be addressed by changes in delivery of the curriculum. The learner-centered approach to education helps to recognize and integrate student diversity with class exercises and assignments designed to help students meet course learning outcomes. This article applies the American…

  5. To Design and Evaluate a 12th Grade Course in the Principles of Economics; Final Report.

    Science.gov (United States)

    Wiggins, Suzanne E.; Sperling, John G.

    Reported is the design, development, and evaluation of a one-semester course on the principles of economics for twelfth grade students. The course is intended to develop students' capacity for economic reasoning through economic theory and empirical research. To do this, teaching materials and innovative techniques for teacher training were…

  6. Opportunity recognition in entrepreneurship education, design principles on fostering competent entrepreneurs in the science domain

    NARCIS (Netherlands)

    Nab, J.; Beugels, J.; van Keulen, H.; Oost, H.; Pilot, A.

    2008-01-01

    This paper is part of a research project focusing on educational design principles that should help students with a background in Science to become competent with respect to opportunity recognition in business. The recognition of business opportunities is one of the basic competencies of entrepreneu

  7. Successfully Teaching Biblical Languages Online at the Seminary Level: Guiding Principles of Course Design and Delivery

    Science.gov (United States)

    Harlow, Joel

    2007-01-01

    Reformed Theological Seminary's Virtual Campus has successfully taught the biblical languages online since 1999. This article describes the theoretical principles that underlie the design and asynchronous delivery of online Greek and Hebrew to part-time adult distance students. The structure and administration of the courses is discussed, as well…

  8. Some handbook references and a summary for ''EMP engineering and design principles''

    International Nuclear Information System (INIS)

    The material in this note contains a number of handbook-oriented references and also constitutes a brief review and summary for the copyrighted publication ''EMP Engineering and Design Principles,'' a book by the Electrical Protection Department, Loop Transmission Division, Bell Telephone Laboratories, Incorporated, Whippany, New Jersey; copyrighted 1975. (WHK)

  9. First principles design of a core bioenergetic transmembrane electron-transfer protein.

    Science.gov (United States)

    Goparaju, Geetha; Fry, Bryan A; Chobot, Sarah E; Wiedman, Gregory; Moser, Christopher C; Dutton, P Leslie; Discher, Bohdana M

    2016-05-01

    Here we describe the design, Escherichia coli expression and characterization of a simplified, adaptable and functionally transparent single chain 4-α-helix transmembrane protein frame that binds multiple heme and light activatable porphyrins. Such man-made cofactor-binding oxidoreductases, designed from first principles with minimal reference to natural protein sequences, are known as maquettes. This design is an adaptable frame aiming to uncover core engineering principles governing bioenergetic transmembrane electron-transfer function and recapitulate protein archetypes proposed to represent the origins of photosynthesis. This article is part of a Special Issue entitled Biodesign for Bioenergetics--the design and engineering of electronic transfer cofactors, proteins and protein networks, edited by Ronald L. Koder and J.L. Ross Anderson. PMID:26672896

  10. Design and Fabrication of Hybrid Piezomotor Applied in Precision Positioning Devices

    Institute of Scientific and Technical Information of China (English)

    CHENG Dong-ming; DUAN Zhi-yong; MA Feng-ying; GONG Qiao-xia

    2007-01-01

    The motor's configuration is designed and the dynamic analysis equations based on its simplified model are deduced. A testing system utilizing grating is set up to test this new motor, and the theoretical movement principle for the motor is proved by experiments. The pulse waveforms are applied to drive the motor to move in steps. The motor has a displacement resolution of 10nm and a maximum velocity of 0.6 mm/s. It can drive a 200 g slider whose range is 20 mm. A one-dimensional precision positioning platform is fabricated by using the new hybrid piezoelectric motor. The prototype is made up of two servomotors and two piezoelectric motors, which are controlled automatically by a computer. The positioning range of the platform is 10 cm.

  11. Design principles for high-pressure force fields: Aqueous TMAO solutions from ambient to kilobar pressures.

    Science.gov (United States)

    Hölzl, Christoph; Kibies, Patrick; Imoto, Sho; Frach, Roland; Suladze, Saba; Winter, Roland; Marx, Dominik; Horinek, Dominik; Kast, Stefan M

    2016-04-14

    Accurate force fields are one of the major pillars on which successful molecular dynamics simulations of complex biomolecular processes rest. They have been optimized for ambient conditions, whereas high-pressure simulations become increasingly important in pressure perturbation studies, using pressure as an independent thermodynamic variable. Here, we explore the design of non-polarizable force fields tailored to work well in the realm of kilobar pressures--while avoiding complete reparameterization. Our key is to first compute the pressure-induced electronic and structural response of a solute by combining an integral equation approach to include pressure effects on solvent structure with a quantum-chemical treatment of the solute within the embedded cluster reference interaction site model (EC-RISM) framework. Next, the solute's response to compression is taken into account by introducing pressure-dependence into selected parameters of a well-established force field. In our proof-of-principle study, the full machinery is applied to N,N,N-trimethylamine-N-oxide (TMAO) in water being a potent osmolyte that counteracts pressure denaturation. EC-RISM theory is shown to describe well the charge redistribution upon compression of TMAO(aq) to 10 kbar, which is then embodied in force field molecular dynamics by pressure-dependent partial charges. The performance of the high pressure force field is assessed by comparing to experimental and ab initio molecular dynamics data. Beyond its broad usefulness for designing non-polarizable force fields for extreme thermodynamic conditions, a good description of the pressure-response of solutions is highly recommended when constructing and validating polarizable force fields. PMID:27083705

  12. Design principles for high-pressure force fields: Aqueous TMAO solutions from ambient to kilobar pressures

    Science.gov (United States)

    Hölzl, Christoph; Kibies, Patrick; Imoto, Sho; Frach, Roland; Suladze, Saba; Winter, Roland; Marx, Dominik; Horinek, Dominik; Kast, Stefan M.

    2016-04-01

    Accurate force fields are one of the major pillars on which successful molecular dynamics simulations of complex biomolecular processes rest. They have been optimized for ambient conditions, whereas high-pressure simulations become increasingly important in pressure perturbation studies, using pressure as an independent thermodynamic variable. Here, we explore the design of non-polarizable force fields tailored to work well in the realm of kilobar pressures - while avoiding complete reparameterization. Our key is to first compute the pressure-induced electronic and structural response of a solute by combining an integral equation approach to include pressure effects on solvent structure with a quantum-chemical treatment of the solute within the embedded cluster reference interaction site model (EC-RISM) framework. Next, the solute's response to compression is taken into account by introducing pressure-dependence into selected parameters of a well-established force field. In our proof-of-principle study, the full machinery is applied to N,N,N-trimethylamine-N-oxide (TMAO) in water being a potent osmolyte that counteracts pressure denaturation. EC-RISM theory is shown to describe well the charge redistribution upon compression of TMAO(aq) to 10 kbar, which is then embodied in force field molecular dynamics by pressure-dependent partial charges. The performance of the high pressure force field is assessed by comparing to experimental and ab initio molecular dynamics data. Beyond its broad usefulness for designing non-polarizable force fields for extreme thermodynamic conditions, a good description of the pressure-response of solutions is highly recommended when constructing and validating polarizable force fields.

  13. Human-on-a-chip design strategies and principles for physiologically based pharmocokinetics/pharmacodynamics modeling

    OpenAIRE

    Abaci, Hasan Erbil; Shuler, Michael L.

    2015-01-01

    Advances in maintaining multiple human tissues on microfluidic platforms has led to a growing interest in developing microphysiological systems for drug development studies. Determining the proper design principles and scaling rules for body-on-a-chip systems is critical for their strategic incorporation into physiologically based pharmacokinetic (PBPK)/pharmacodynamic model (PD) -aided drug development. While the need for a functional design considering organ-organ interactions has been cons...

  14. The principles of designing of algorithm for speech synthesis from texts written in Albanian language

    OpenAIRE

    Agni Dika; Adnan Maxhuni; Avni Rexhepi

    2012-01-01

    The speech synthesis is artificial generation of human speech from written texts. For this purpose, adequate algorithms are designed, which then through relevant programs make it possible to synthesize texts to speech. The process of converting text into speech is also known as Text-To-Speech (TTS) system [5]. In this paper are given basic principles to be used when designing a system to synthesize speech in Albanian language from written texts. Currently there are solutions that enable natur...

  15. High-throughput spectrometer designs in a compact form-factor: principles and applications

    Science.gov (United States)

    Norton, S. M.

    2013-05-01

    Many compact, portable Raman spectrometers have entered the market in the past few years with applications in narcotics and hazardous material identification, as well as verification applications in pharmaceuticals and security screening. Often, the required compact form-factor has forced designers to sacrifice throughput and sensitivity for portability and low-cost. We will show that a volume phase holographic (VPH)-based spectrometer design can achieve superior throughput and thus sensitivity over conventional Czerny-Turner reflective designs. We will look in depth at the factors influencing throughput and sensitivity and illustrate specific VPH-based spectrometer examples that highlight these design principles.

  16. Designing Social Interfaces Principles, Patterns, and Practices for Improving the User Experience

    CERN Document Server

    Crumlish, Christian

    2009-01-01

    From the creators of Yahoo!'s Design Pattern Library, Designing Social Interfaces provides you with more than 100 patterns, principles, and best practices, along with salient advice for many of the common challenges you'll face when starting a social website. Designing sites that foster user interaction and community-building is a valuable skill for web developers and designers today, but it's not that easy to understand the nuances of the social web. Now you have help. Christian Crumlish and Erin Malone share hard-won insights into what works, what doesn't, and why. You'll learn how to bala

  17. Optimal Input Design for Aircraft Parameter Estimation using Dynamic Programming Principles

    Science.gov (United States)

    Morelli, Eugene A.; Klein, Vladislav

    1990-01-01

    A new technique was developed for designing optimal flight test inputs for aircraft parameter estimation experiments. The principles of dynamic programming were used for the design in the time domain. This approach made it possible to include realistic practical constraints on the input and output variables. A description of the new approach is presented, followed by an example for a multiple input linear model describing the lateral dynamics of a fighter aircraft. The optimal input designs produced by the new technique demonstrated improved quality and expanded capability relative to the conventional multiple input design method.

  18. Applying Universal Design for Learning in Online Courses: Pedagogical and Practical Considerations

    Science.gov (United States)

    Dell, Cindy Ann; Dell, Thomas F.; Blackwell, Terry L.

    2015-01-01

    Inclusion of the universal design for learning (UDL) model as a guiding set of principles for online curriculum development in higher education is discussed. Fundamentally, UDL provides the student with multiple means of accessing the course based on three overarching principles: presentation; action and expression; and engagement and interaction.…

  19. Sensitivity Analysis Applied in Design of Low Energy Office Building

    DEFF Research Database (Denmark)

    Heiselberg, Per; Brohus, Henrik

    2008-01-01

    Building performance can be expressed by different indicators as primary energy use, environmental load and/or the indoor environmental quality and a building performance simulation can provide the decision maker with a quantitative measure of the extent to which an integrated design solution...... satisfies the design requirements and objectives. In the design of sustainable Buildings it is beneficial to identify the most important design parameters in order to develop more efficiently alternative design solutions or reach optimized design solutions. A sensitivity analysis makes it possible...... to identify the most important parameters in relation to building performance and to focus design and optimization of sustainable buildings on these fewer, but most important parameters. The sensitivity analyses will typically be performed at a reasonably early stage of the building design process, where...

  20. The analytical hierarchy process applied for design analysis

    NARCIS (Netherlands)

    Ciftcioglu, O.; Sariyildiz, I.S.

    2005-01-01

    Being an intelligent activity, design is a complex process to accomplish. The complexity stems from the elusive character of this activity, which cannot be explained in precise terms, in general. In a design process, the determined relationships among the design elements provide important informatio

  1. Applying Quality Function Deployment in Industrial Design Curriculum Planning

    Science.gov (United States)

    Liu, Shuo-Fang; Lee, Yann-Long; Lin, Yi-Zhi; Tseng, Chien-Feng

    2013-01-01

    Industrial design is a discipline that combines multiple professional fields. Enterprise demands for industrial design competencies also change over time; thus, the curriculum of industrial design education should be compatible with the current demands of the industry. However, scientific approaches have not been previously employed to plan…

  2. Designing a New Program in Family Relations and Applied Nutrition

    Science.gov (United States)

    Devine, Sharon Mayne; Daly, Kerry; Lero, Donna; MacMartin, Clare

    2007-01-01

    Family Relations and Applied Nutrition, which is offered at the University of Guelph, is an interdisciplinary department that previously offered three undergraduate majors: child, youth, and family; applied human nutrition; and gerontology; as well as graduate programs at the master's and doctoral levels. Several factors have precipitated a review…

  3. Seismic design principles for the German fast breeder reactor SNR2

    International Nuclear Information System (INIS)

    The leading aim of a seismic design is, besides protection against seismic impacts, not to enhance the overall risk in the absence of seismic vibrations and, secondly, to avoid competition between operational needs and a seismic structural design. This approach is supported by avoiding overconservatism in the assumption of seismic loads and in the calculation of the structural response. Accordingly the seismic principles are stated as follows: restriction to German or equivalent low seismicity sites with intensities (SSE) lower VIII at frequency lower than 10-4/year; best estimate of seismic input-data without further conservatism; no consideration of OBE. The structural design principles are: 1. The secondary character of the seismic excitation is explicitly accounted for; 2. Energy absorption is allowed for by ductility of materials and construction. Accordingly strain criteria are used for failure predictions instead of stress criteria. (author). 1 fig

  4. Zebrafish housing systems: a review of basic operating principles and considerations for design and functionality.

    Science.gov (United States)

    Lawrence, Christian; Mason, Timothy

    2012-01-01

    The strategies for housing zebrafish used in biomedical research have evolved considerably over the past three decades. To keep pace with the rapid expansion and development of the zebrafish model system, the field has generally moved from keeping fish at the level of aquarium hobbyist to that of industrialized, recirculating aquaculture. Numerous commercial system vendors now offer increasingly sophisticated housing systems based on design principles that maximize the number of animals that can be housed in a given space footprint, and they are thus able to support large and diverse research programs. This review is designed to provide managers, lab animal veterinarians, investigators, and other parties responsible for care and use of these animals with a comprehensive overview of the basic operating and design principles of zebrafish housing systems. This information can be used to help plan the construction of new facilities and/or the upgrade and maintenance of existing operations. PMID:23382349

  5. [(18)F]-Organotrifluoroborates as Radioprosthetic Groups for PET Imaging: From Design Principles to Preclinical Applications.

    Science.gov (United States)

    Perrin, David M

    2016-07-19

    Positron emission tomography (PET) is revolutionizing our ability to visualize in vivo targets for target validation and personalized medicine. Of several classes of imaging agents, peptides afford high affinity and high specificity to distinguish pathologically distinct cell types by the presence of specific molecular targets. Of various available PET isotopes, [(18)F]-fluoride ion is preferred because of its excellent nuclear properties and on-demand production in hospitals at Curie levels. However, the short half-life of (18)F and its lack of reactivity in water continue to challenge peptide labeling. Hence, peptides are often conjugated to a metal chelator for late-stage, one-step labeling. Yet radiometals, while effective, are neither as desirable nor as available as [(18)F]-fluoride ion. Despite considerable past success in identifying semifeasible radiosyntheses, significant challenges continue to confound tracer development. These interrelated challenges relate to (1) isotope/prosthetic choice; (2) bioconjugation for high affinity; (3) high radiochemical yields, (4) specific activities of >1 Ci/μmol to meet FDA microdose requirements; and (5) rapid clearance and in vivo stability. These enduring challenges have been extensively highlighted, while a single-step, operationally simple, and generally applicable means of labeling a peptide with [(18)F]-fluoride ion in good yield and high specific activity has eluded radiochemists and nuclear medicine practitioners for decades. Radiosynthetic ease is of primordial importance since multistep labeling reactions challenge clinical tracer production. In the past decade, as we sought to meet this challenge, appreciation of reactions with aqueous fluoride led us to consider organotrifluoroborate (RBF3(-)) synthesis as a means of rapid aqueous peptide labeling. We have applied principles of mechanistic chemistry, knowledge of chemical reactivity, and synthetic chemistry to design stable RBF3(-)s. Over the past 10 years

  6. The Principles and Process of Materials Design:A case study

    Institute of Scientific and Technical Information of China (English)

    苏艺

    2004-01-01

    Designing materials for one's own class is part of most EFL teachers' experience and some even have the opportunity to prepare materials for a wider readership but how many of these writers have studied the principles and process of material design? In the following account a teacher from Guangdong Province, China reports on her preparation of an English language course before she had read anything on the topic. She interweaves this account with reflections following her later study of materials design during postgraduate studies in New Zealand. She makes comparisons and contrasts between what she did in practice and the theories she later read about.

  7. The principle of complementarity in the design of reserve networks to conserve biodiversity: a preliminary history

    Indian Academy of Sciences (India)

    James Justus; Sahotra Sarkar

    2002-07-01

    Explicit, quantitative procedures for identifying biodiversity priority areas are replacing the often ad hoc procedures used in the past to design networks of reserves to conserve biodiversity. This change facilitates more informed choices by policy makers, and thereby makes possible greater satisfaction of conservation goals with increased efficiency. A key feature of these procedures is the use of the principle of complementarity, which ensures that areas chosen for inclusion in a reserve network complement those already selected. This paper sketches the historical development of the principle of complementarity and its applications in practical policy decisions. In the first section a brief account is given of the circumstances out of which concerns for more explicit systematic methods for the assessment of the conservation value of different areas arose. The second section details the emergence of the principle of complementarity in four independent contexts. The third section consists of case studies of the use of the principle of complementarity to make practical policy decisions in Australasia, Africa, and America. In the last section, an assessment is made of the extent to which the principle of complementarity transformed the practice of conservation biology by introducing new standards of rigor and explicitness.

  8. Modeling Organizational Design - Applying A Formalism Model From Theoretical Physics

    OpenAIRE

    Robert Fabac; Josip Stepanić

    2008-01-01

    Modern organizations are exposed to diverse external environment influences. Currently accepted concepts of organizational design take into account structure, its interaction with strategy, processes, people, etc. Organization design and planning aims to align this key organizational design variables. At the higher conceptual level, however, completely satisfactory formulation for this alignment doesn’t exist. We develop an approach originating from the application of concepts of theoretical ...

  9. DESIGNS FOR MIXTURE AND PROCESS VARIABLES APPLIED IN TABLET FORMULATIONS

    NARCIS (Netherlands)

    DUINEVELD, CAA; SMILDE, AK; DOORNBOS, DA

    1993-01-01

    Although there are several methods for the construction of a design for process variables and mixture variables, there are not very many methods which are suitable to combine mixture and process variables in one design. Some of the methods which are feasible will be shown. These methods will be comp

  10. Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling.

    Science.gov (United States)

    Abaci, Hasan Erbil; Shuler, Michael L

    2015-04-01

    Advances in maintaining multiple human tissues on microfluidic platforms has led to a growing interest in the development of microphysiological systems for drug development studies. Determination of the proper design principles and scaling rules for body-on-a-chip systems is critical for their strategic incorporation into physiologically based pharmacokinetic (PBPK)/pharmacodynamic (PD) model-aided drug development. While the need for a functional design considering organ-organ interactions has been considered, robust design criteria and steps to build such systems have not yet been defined mathematically. In this paper, we first discuss strategies for incorporating body-on-a-chip technology into the current PBPK modeling-based drug discovery to provide a conceptual model. We propose two types of platforms that can be involved in the different stages of PBPK modeling and drug development; these are μOrgans-on-a-chip and μHuman-on-a-chip. Then we establish the design principles for both types of systems and develop parametric design equations that can be used to determine dimensions and operating conditions. In addition, we discuss the availability of the critical parameters required to satisfy the design criteria, consider possible limitations for estimating such parameter values and propose strategies to address such limitations. This paper is intended to be a useful guide to the researchers focused on the design of microphysiological platforms for PBPK/PD based drug discovery. PMID:25739725

  11. Applying learning theories and instructional design models for effective instruction.

    Science.gov (United States)

    Khalil, Mohammed K; Elkhider, Ihsan A

    2016-06-01

    Faculty members in higher education are involved in many instructional design activities without formal training in learning theories and the science of instruction. Learning theories provide the foundation for the selection of instructional strategies and allow for reliable prediction of their effectiveness. To achieve effective learning outcomes, the science of instruction and instructional design models are used to guide the development of instructional design strategies that elicit appropriate cognitive processes. Here, the major learning theories are discussed and selected examples of instructional design models are explained. The main objective of this article is to present the science of learning and instruction as theoretical evidence for the design and delivery of instructional materials. In addition, this article provides a practical framework for implementing those theories in the classroom and laboratory.

  12. Modeling Organizational Design - Applying A Formalism Model From Theoretical Physics

    Directory of Open Access Journals (Sweden)

    Robert Fabac

    2008-06-01

    Full Text Available Modern organizations are exposed to diverse external environment influences. Currently accepted concepts of organizational design take into account structure, its interaction with strategy, processes, people, etc. Organization design and planning aims to align this key organizational design variables. At the higher conceptual level, however, completely satisfactory formulation for this alignment doesn’t exist. We develop an approach originating from the application of concepts of theoretical physics to social systems. Under this approach, the allocation of organizational resources is analyzed in terms of social entropy, social free energy and social temperature. This allows us to formalize the dynamic relationship between organizational design variables. In this paper we relate this model to Galbraith's Star Model and we also suggest improvements in the procedure of the complex analytical method in organizational design.

  13. Self-Adaptive Stepsize Search Applied to Optimal Structural Design

    Science.gov (United States)

    Nolle, L.; Bland, J. A.

    Structural engineering often involves the design of space frames that are required to resist predefined external forces without exhibiting plastic deformation. The weight of the structure and hence the weight of its constituent members has to be as low as possible for economical reasons without violating any of the load constraints. Design spaces are usually vast and the computational costs for analyzing a single design are usually high. Therefore, not every possible design can be evaluated for real-world problems. In this work, a standard structural design problem, the 25-bar problem, has been solved using self-adaptive stepsize search (SASS), a relatively new search heuristic. This algorithm has only one control parameter and therefore overcomes the drawback of modern search heuristics, i.e. the need to first find a set of optimum control parameter settings for the problem at hand. In this work, SASS outperforms simulated-annealing, genetic algorithms, tabu search and ant colony optimization.

  14. Using of object-oriented design principles in electric machines development

    OpenAIRE

    N.N. ZABLODSKII; V.E. Pliugin; A.N. Petrenko

    2016-01-01

    Purpose. To develop the theoretical basis of electrical machines object-oriented design, mathematical models and software to improve their design synthesis, analysis and optimization. Methodology. We have applied object-oriented design theory in electric machines optimal design and mathematical modelling of electromagnetic transients and electromagnetic field distribution. We have correlated the simulated results with the experimental data obtained by means of the double-stator screw dryer wi...

  15. Roots of Performance - Aided Design in Utzon´s design principles

    DEFF Research Database (Denmark)

    Parigi, Dario

    2014-01-01

    This paper discuss an emerging paradigm here identified as PAD, acronym of Performance-Aided Design, that aims at embracing complexity in the design process, and tackling it with digital tools. Computer Aided Design tools are gradually shifting from the mere translation of the work once carried o...

  16. Applying conceptual design to B2B sales negotiations

    DEFF Research Database (Denmark)

    Illi, Mikko; Ylirisku, Salu

    , service, configuration and customisation of the products in their company as well as to develop an apposite understanding of the key values and characteristics of the client organisation. Based on a design-ethnographical study of real sales practice in lift truck business the paper draws parallels between......This paper addresses the challenge of perceiving B2B sales negotiation in a manner that would open up new possibilities for the improvement of the practice. B2B sales agents work under high pressure in developing relevant and appealing proposals when negotiating for a deal with a customer. The key...... sales agent’s work practice and collaborative conceptual design work, i.e. innovation design work. This perception provides a means to understand the value that the use of conceptual design tools could possibly provide for sales negotiation work. We also use the notion of boundary object to elaborate...

  17. On extracting design principles from biology: I. Method–General answers to high-level design questions for bioinspired robots

    International Nuclear Information System (INIS)

    When millions of years of evolution suggest a particular design solution, we may be tempted to abandon traditional design methods and copy the biological example. However, biological solutions do not often translate directly into the engineering domain, and even when they do, copying eliminates the opportunity to improve. A better approach is to extract design principles relevant to the task of interest, incorporate them in engineering designs, and vet these candidates against others. This paper presents the first general framework for determining whether biologically inspired relationships between design input variables and output objectives and constraints are applicable to a variety of engineering systems. Using optimization and statistics to generalize the results beyond a particular system, the framework overcomes shortcomings observed of ad hoc methods, particularly those used in the challenging study of legged locomotion. The utility of the framework is demonstrated in a case study of the relative running efficiency of rotary-kneed and telescoping-legged robots. (paper)

  18. Basic Principles of Industrial Electric Power Network Computer Aided Design and Engineering

    Directory of Open Access Journals (Sweden)

    M. Fursanov

    2012-01-01

    Full Text Available A conceptual model for a computer aided design and engineering system has been developed in the paper. The paper presents basic automation process principles including a graphical representation   network and calculation results, convenient user interface, automatic mode calculation, selection of transformer rated power and cross-section area of wires. The developed algorithm and program make it possible to save time and improve quality of project implementation.

  19. Zebrafish Housing Systems: A Review of Basic Operating Principles and Considerations for Design and Functionality

    OpenAIRE

    Lawrence, Christian; Mason, Timothy

    2012-01-01

    The strategies for housing zebrafish used in biomedical research have evolved considerably over the past three decades. To keep pace with the rapid expansion and development of the zebrafish model system, the field has generally moved from keeping fish at the level of aquarium hobbyist to that of industrialized, recirculating aquaculture. Numerous commercial system vendors now offer increasingly sophisticated housing systems based on design principles that maximize the number of animals that ...

  20. Designing IS Curricula for Practical Relevance: Applying Baseball's "Moneyball" Theory

    Science.gov (United States)

    Surendra, Nanda C.; Denton, James W.

    2009-01-01

    Baseball's "Moneyball" theory states that the baseball market undervalues some attributes (and players with these attributes) that are key contributors to wins while overvaluing other attributes. Teams who correctly evaluate attributes that contribute to wins have higher winning percentages with relatively low payrolls. We applied the Moneyball…

  1. Structural principles for computational and de novo design of 4Fe-4S metalloproteins.

    Science.gov (United States)

    Nanda, Vikas; Senn, Stefan; Pike, Douglas H; Rodriguez-Granillo, Agustina; Hansen, Will A; Khare, Sagar D; Noy, Dror

    2016-05-01

    Iron-sulfur centers in metalloproteins can access multiple oxidation states over a broad range of potentials, allowing them to participate in a variety of electron transfer reactions and serving as catalysts for high-energy redox processes. The nitrogenase FeMoCO cluster converts di-nitrogen to ammonia in an eight-electron transfer step. The 2(Fe4S4) containing bacterial ferredoxin is an evolutionarily ancient metalloprotein fold and is thought to be a primordial progenitor of extant oxidoreductases. Controlling chemical transformations mediated by iron-sulfur centers such as nitrogen fixation, hydrogen production as well as electron transfer reactions involved in photosynthesis are of tremendous importance for sustainable chemistry and energy production initiatives. As such, there is significant interest in the design of iron-sulfur proteins as minimal models to gain fundamental understanding of complex natural systems and as lead-molecules for industrial and energy applications. Herein, we discuss salient structural characteristics of natural iron-sulfur proteins and how they guide principles for design. Model structures of past designs are analyzed in the context of these principles and potential directions for enhanced designs are presented, and new areas of iron-sulfur protein design are proposed. This article is part of a Special issue entitled Biodesign for Bioenergetics--the design and engineering of electronic transfer cofactors, protein networks, edited by Ronald L. Koder and J.L Ross Anderson.

  2. THE PRINCIPLE OF REASONED SHAPE FORMING AS A BASIS FOR PLASTIC ADEQUACY OF DESIGN OBJECTS

    Directory of Open Access Journals (Sweden)

    Vitaly Vasilyevich Miroshnikov

    2015-01-01

    Full Text Available The article highlights the basic approaches to configuring the form in design. The authors analyze the main strategies of shape formation in modern design practices. The novelty of the subject is that the analysis is carried out in the context of the adequacy of the design of plastic objects. The essence of the problems outlined by the authors is inconsistency between the object’s semantics and its external form resulted from incorrect practices of shape formation. Consideration of strategies and tactics of configuration of forms is based on comparison of two principles of shape formation - intuitive and discursive. The aim of the authors is to identify the reasons and structural specificity of intuitive and discursive practices of shape formation in design and to show the priority of the discursive approach. Attention of the authors is focused on the differences of search algorithms and results of shaping which are characteristic for the principles under consideration. The arguments cited in the article determine the discursive strategy of form configuration as the most correct and efficient in terms of design engineering. In the process of analyzing the basic algorithms of shape formation, of topical importance is the concept of legitimacy of form as a definition of the most appropriate process and a results of the project research. The article gives the interpretation of legitimacy in terms of the project practices and design - education.

  3. Using articulation and inscription as catalysts for reflection: Design principles for reflective inquiry

    Science.gov (United States)

    Loh, Ben Tun-Bin

    2003-07-01

    The demand for students to engage in complex student-driven and information-rich inquiry investigations poses challenges to existing learning environments. Students are not familiar with this style of work, and lack the skills, tools, and expectations it demands, often forging blindly forward in the investigation. If students are to be successful, they need to learn to be reflective inquirers, periodically stepping back from an investigation to evaluate their work. The fundamental goal of my dissertation is to understand how to design learning environments to promote and support reflective inquiry. I have three basic research questions: how to define this mode of work, how to help students learn it, and understanding how it facilitates reflection when enacted in a classroom. I take an exploratory approach in which, through iterative cycles of design, development, and reflection, I develop principles of design for reflective inquiry, instantiate those principles in the design of a software environment, and test that software in the context of classroom work. My work contributes to the understanding of reflective inquiry in three ways: First, I define a task model that describes the kinds of operations (cognitive tasks) that students should engage in as reflective inquirers. These operations are defined in terms of two basic tasks: articulation and inscription, which serve as catalysts for externalizing student thinking as objects of and triggers for reflection. Second, I instantiate the task model in the design of software tools (the Progress Portfolio). And, through proof of concept pilot studies, I examine how the task model and tools helped students with their investigative classroom work. Finally, I take a step back from these implementations and articulate general design principles for reflective inquiry with the goal of informing the design of other reflective inquiry learning environments. There are three design principles: (1) Provide a designated work space

  4. Applying axiomatic design to a medication distribution system

    Science.gov (United States)

    Raguini, Pepito B.

    As the need to minimize medication errors drives many medical facilities to come up with robust solutions to the most common error that affects patient's safety, these hospitals would be wise to put a concerted effort into finding methodologies that can facilitate an optimized medical distribution system. If the hospitals' upper management is looking for an optimization method that is an ideal fit, it is just as important that the right tool be selected for the application at hand. In the present work, we propose the application of Axiomatic Design (AD), which is a process that focuses on the generation and selection of functional requirements to meet the customer needs for product and/or process design. The appeal of the axiomatic approach is to provide both a formal design process and a set of technical coefficients for meeting the customer's needs. Thus, AD offers a strategy for the effective integration of people, design methods, design tools and design data. Therefore, we propose the AD methodology to medical applications with the main objective of allowing nurses the opportunity to provide cost effective delivery of medications to inpatients, thereby improving quality patient care. The AD methodology will be implemented through the use of focused stores, where medications can be readily stored and can be conveniently located near patients, as well as a mobile apparatus that can also store medications and is commonly used by hospitals, the medication cart. Moreover, a robust methodology called the focused store methodology will be introduced and developed for both the uncapacitated and capacitated case studies, which will set up an appropriate AD framework and design problem for a medication distribution case study.

  5. An alternative policy evaluation of the British Columbia carbon tax: broadening the application of Elinor Ostrom's design principles for managing common-pool resources

    Directory of Open Access Journals (Sweden)

    Karine Lacroix

    2015-06-01

    Full Text Available Climate change is putting infrastructure, food supply, water resources, ecosystems, and human health at risk. These risks will be exacerbated depending on the degree of additional greenhouse gas emissions. Urgent action is needed to limit the severity of impacts associated with further warming. British Columbia (BC has taken action to reduce greenhouse gas emissions from carbon-based fuels by introducing a carbon tax in 2008. As an innovative approach to climate change mitigation, especially in North America, studies evaluating its effectiveness are valuable. We assessed the long-term viability potential of the BC carbon tax using common pool resource design principles, a novel application of the design principles to environmental policy. We found that the design principles can be applied productively to environmental policy and larger scale air pollution problems. With regard to the BC carbon tax, our findings suggest that closer monitoring of user behavior, further increases of the tax over time, and pursuing efforts for a more elaborate system of nested enterprises and interjurisdictional cooperation could increase the long-term success of the BC carbon tax. We also found that the design principles allowed us to more comprehensively reach conclusions regarding the broader effectiveness of the tax when compared to existing policy analysis. Traditionally, climate policy evaluation has focused on the end goal without considering broader constraints and issues of resource allocation. We suggest that common pool resource theory, which is based on strong theoretical principles and encourages reflexivity, will be able to address those limitations.

  6. APPLIED KNOWLEDGE MANAGEMENT IN SMALL DESIGN FIRMS: CASE STUDY

    Directory of Open Access Journals (Sweden)

    Christian Donin

    2016-09-01

    Full Text Available Knowledge is the new strategic imperative of organizations. The ability to manage knowledge is a crucial part of any organizations operational processes. The creation and diffusion of knowledge have become ever more important factors in competitiveness. This paper investigates the Knowledge Management and flow information and in small design firms. It is divided into three main parts. The first part of this paper describes the importance of Knowledge Management for organizations are described together with responsibilities needed to ensure successful Knowledge Management implementations and the Spiral of Organizational Knowledge Creation conception. The second part approaches literature available about process and organizational structure and information flow related to Brazilian design firms. Finally, this paper presents a case study of small design office of Civil Engineering identifying organizational process, verifying the types of communication practices and identifying the types of dynamic process of The Spiral of Organizational Knowledge Creation, KM strategy and dynamic through Knowledge Transfer.

  7. Applying Additive Manufacturing to a New Liquid Oxygen Turbopump Design

    Science.gov (United States)

    O'Neal, Derek

    2016-01-01

    A liquid oxygen turbopump has been designed at Marshall Space Flight Center as part of the in-house, Advanced Manufacturing Demonstrator Engine (AMDE) project. Additive manufacturing, specifically direct metal laser sintering (DMLS) of Inconel 718, is used for 77% of the parts by mass. These parts include the impeller, turbine components, and housings. The near-net shape DMLS parts have been delivered and final machining is underway. Fabrication of the traditionally manufactured hardware is also proceeding. Testing in liquid oxygen is planned for Q2 of FY2017. This topic explores the design of the turbopump along with fabrication and material testing of the DMLS hardware.

  8. Applying and incorporating user driven innovation when designing concepts

    DEFF Research Database (Denmark)

    Thorp Hansen, Claus; Brønnum, Louise

    a design practice explicitly considering the type of user insights this approach implies. For that reason UDI has yet to prove itself and its potential effect; a study of Danish initiative “program for user driven innovation” has shown little effect in this regard. However it has shown that radical new....... This paper is based on practical experience working with theoretical concept frameworks, which have induced new perspectives in a reframing. We will account for the concept design process and why a reframing is called for when working with user research, leading to a proposal for new dimensions...

  9. Applying design of experiments to a compression refrigeration cycle

    Directory of Open Access Journals (Sweden)

    Nuno Ricardo Costa

    2015-12-01

    Full Text Available Refrigeration cycles are used in a large diversity of industrial and domestic (residential and non-residential equipment and their efficiency depend on several variables. To better understanding of how controllable variables impact on a compression refrigeration cycle efficiency, statistically designed experiments were conducted and data were analyzed. A quadratic polynomial model was fitted to Coefficient of Performance and variable settings to maximize cycle efficiency identified. Results give confidence to use the illustrated approach for refrigeration cycle design and operation improvement purposes.

  10. Designation and Implementation of Microcomputer Principle and Interface Technology Virtual Experimental Platform Website

    Science.gov (United States)

    Gao, JinYue; Tang, Yin

    This paper explicitly discusses the designation and implementation thought and method of Microcomputer Principle and Interface Technology virtual experimental platform website construction. The instructional design of this platform mainly follows with the students-oriented constructivism learning theory, and the overall structure is subject to the features of teaching aims, teaching contents and interactive methods. Virtual experiment platform production and development should fully take the characteristics of network operation into consideration and adopt relevant technologies to improve the effect and speed of network software application in internet.

  11. Code of practice and design principles for portable and transportable radiological protection systems

    International Nuclear Information System (INIS)

    The Code of Practice and design principles for portable and transportable radiological protection systems are presented in three parts. Part 1 specifies the requirement for Radiological Protection Instrumentation (RPI) including operational characteristics and the effects of both a radiation and non-radiation environment. Part 2 satisfies the requirement for RPI equipment as regards the overall design, the availability, the reliability, the information display, the human factors, the power supplies, the manufacture and quality assurance, the testing and the cost. Part 3 deals with the supply, location and operation of the RPI equipment. (U.K.)

  12. Commutation possibilities of reverse-connected dynistors and principles of RCD-circuit design (review)

    International Nuclear Information System (INIS)

    One generalized the results of investigation into the reverse-connected dynistors (RCD) designed for pulsed and conversion equipment high-power facilities. Paper describes the basic design principles for high-power RCD-switches and the base circuits of pulsed and high-frequency facilities based on RCD. Paper contains the results of tests of high-voltage microsecond and submicrosecond RCD-generators with 108-1010 W pulse intensity and of high-frequency RCD-inverters with 104-105 W average intensity

  13. Control room philosophy: Principles of control room design and control room work

    International Nuclear Information System (INIS)

    In order to provide insights for improvement of work in control rooms several factors have to be considered. Knowledge of principles including control room philosophies will guide the recommended improvements. In addition to knowledge about specific principles an advantage for an organization can be an understanding of similarities and policies used in other high risk industry. The report has been developed on the basis of a document analysis of international standards and other guiding documents. (NUREG 0711, ISO 11064, ISO 6385, IEC 60964). In addition to the document analysis which has strived to compare the documents to see similarities in important principals, experience from working with control room design, modifications and evaluations in other high risk industries has pervaded the report. Important principles have been identified which are recommended to be included in a control room philosophy. Many of these are similar to the principles identified in the international standards. An additional principal which is regarded as important is the utilization of Key Performance Indicators (KPI) which can be used as a measure to target preventative means. Further more it is critical that the control room philosophy is easy to access and comprehend for all users. One of the challenges that remain after having developed a control room philosophy is how to utilize it in the daily work situation. It is vital that the document remains as a living document, guiding the continual improvement of the control room in the various life cycle stages

  14. Applying Learning Theories and Instructional Design Models for Effective Instruction

    Science.gov (United States)

    Khalil, Mohammed K.; Elkhider, Ihsan A.

    2016-01-01

    Faculty members in higher education are involved in many instructional design activities without formal training in learning theories and the science of instruction. Learning theories provide the foundation for the selection of instructional strategies and allow for reliable prediction of their effectiveness. To achieve effective learning…

  15. Applying the Five-Factor Model to Game Design

    OpenAIRE

    Bildtgård, Marcus

    2014-01-01

    What makes us like or dislike certain games? Is there relation between our tastes in games and our personalities and can it be measured? This dissertation examines gamer personalities and game attributes with the help of the Five-Factor Model, also called The Big Five. It treats an experiment on how to apply the Five-Factor Model to games and their players and what it may be used for. By interviewing gamers, recording their favored and unfavored games, letting the gamers take a Big Five perso...

  16. Leaky Mode Engineering: A General Design Principle for Dielectric Optical Antenna Solar Absorbers

    CERN Document Server

    Yu, Yiling

    2014-01-01

    We present a general principle for the rational design of dielectric optical anatennas with optimal solar absorption: leaky mode engineering. This builds upon our previous study that demonstrates the solar absorption in a given amount of materials dictated by the modal properties of leaky modes. Here we synergistically examine the correlation among the modal properties of leaky modes, the physical features of dielectric structures, and the solar absorption in these structures. Our analysis clearly points out the general guideline for the design of dielectric optical antennas with optimal solar absorption enhenacement: a) using 0D structures; b) the shape does not matter much; c) heterostructuring with non-absorbing materials is a promising strategy; d) the design of a large-scale nanostructure array can literally build upon the design of single nanostructure solar absorbers.

  17. Applying design of experiments to a compression refrigeration cycle

    OpenAIRE

    Nuno Ricardo Costa; João Garcia

    2015-01-01

    Refrigeration cycles are used in a large diversity of industrial and domestic (residential and non-residential) equipment and their efficiency depend on several variables. To better understanding of how controllable variables impact on a compression refrigeration cycle efficiency, statistically designed experiments were conducted and data were analyzed. A quadratic polynomial model was fitted to Coefficient of Performance and variable settings to maximize cycle efficiency identified. Results ...

  18. Preliminary design enhancement by incorporating set- based design principles and a navigator

    OpenAIRE

    Dobrovolskyte, Nora

    2015-01-01

    The need for improvement of Product Development (PD) processes has been demonstrated by a high demand for the aerospace products to be developed quicker and cheaper. Set-Based Design (SBD) can improve the ability to respond faster to customers’ requirements by developing a set of design solutions for possible future product orders in parallel. In SBD participants practise SBCE (Set-Based Concurrent Engineering) by reasoning, developing and communicating about sets of solutions ...

  19. [Information and communication technologies in teaching applied and experimental designs].

    Science.gov (United States)

    Bono, Roser; Arnau, Jaume; Blanca, María J

    2006-08-01

    In this work, an innovative teaching model applied to methodological contents in psychology is presented. The proposed didactic model includes Information and Communication Technologies (ICT), such as CD-ROMs, web sites and Internet. These resources complement class attendance. In the classes the students are informed, guided and oriented so that they are able to obtain information and reorganize it in a coherent way. The aim of this article is to find out the students' learning preferences and estimate the incorporation of ICT, by means of the ETIM (Evaluation of Teaching Innovation Model) questionnaire. The results show that the students are aware of the need to consult other materials and that ICT helps students to understand the subject from various perspectives. In this way, the students become more autonomous in acquiring learning results. PMID:17296099

  20. Applying UML and MDA to Real Systems Design

    CERN Document Server

    Oliver, Ian

    2011-01-01

    Traditionally system design has been made from a black box/functionality only perspective which forces the developer to concentrate on how the functionality can be decomposed and recomposed into so called components. While this technique is well established and well known it does suffer fromsome drawbacks; namely that the systems produced can often be forced into certain, incompatible architectures, difficult to maintain or reuse and the code itself difficult to debug. Now that ideas such as the OMG's Model Based Architecture (MDA) or Model Based Engineering (MBE) and the ubiquitous modelling language UML are being used (allegedly) and desired we face a number of challenges to existing techniques.

  1. Geo-environmental mapping tool applied to pipeline design

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, Karina de S.; Calle, Jose A.; Gil, Euzebio J. [Geomecanica S/A Tecnologia de Solo Rochas e Materiais, Rio de Janeiro, RJ (Brazil); Sare, Alexandre R. [Geomechanics International Inc., Houston, TX (United States); Soares, Ana Cecilia [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil)

    2009-07-01

    The Geo-Environmental Mapping is an improvement of the Geological-Geotechnical Mapping used for basic pipeline designs. The main purpose is to assembly the environmental, geotechnical and geological concepts in a methodological tool capable to predict constrains and reduce the pipeline impact to the environment. The Geo-Environmental mapping was built to stress the influence of soil/structure interaction, related to the physical effect that comes from the contact between structures and soil or rock. A Geological-Geotechnical-Environmental strip (chart) was presented to emphasize the pipeline operational constrains and its influence to the environment. The mapping was developed to clearly show the occurrence and properties of geological materials divided into geotechnical domain units (zones). The strips present construction natural properties, such as: excavability, stability of the excavation and soil re-use capability. Also, the environmental constrains were added to the geological-geotechnical mapping. The Geo-Environmental Mapping model helps the planning of the geotechnical and environmental inquiries to be carried out during executive design, the discussion on the types of equipment to be employed during construction and the analysis of the geological risks and environmental impacts to be faced during the built of the pipeline. (author)

  2. Principles of loads and failure mechanisms applications in maintenance, reliability and design

    CERN Document Server

    Tinga, T

    2013-01-01

    Failure of components or systems must be prevented by both designers and operators of systems, but knowledge of the underlying mechanisms is often lacking. Since the relation between the expected usage of a system and its failure behavior is unknown, unexpected failures often occur, with possibly serious financial and safety consequences. Principles of Loads and Failure Mechanisms.  Applications in Maintenance, Reliability and Design provides a complete overview of all relevant failure mechanisms, ranging from mechanical failures like fatigue and creep to corrosion and electric failures. Both qualitative and quantitative descriptions of the mechanisms and their governing loads enable a solid assessment of a system’s reliability in a given or assumed operational context. Moreover, a unique range of applications of this knowledge in the fields of maintenance, reliability and design are presented. The benefits of understanding the physics of failure are demonstrated for subjects like condition monitoring, pre...

  3. Design principles and fundamental trade-offs in biomimetic light harvesting

    CERN Document Server

    Sarovar, Mohan

    2012-01-01

    Recent developments in synthetic and supramolecular chemistry have created opportunities to design organic systems with tailored nanoscale structure for various technological applications. A key application area is the capture of light energy and its conversion into electrochemical or chemical forms for photovoltaic or sensing applications. In this work we consider cylindrical assemblies of chromophores that model structures produced by several supramolecular techniques. Our study is especially guided by the versatile structures produced by virus-templated assembly. We use a multi-objective optimization framework to determine design principles and limitations in light harvesting performance for such assemblies, both in the presence and absence of disorder. We identify a fundamental trade-off in cylindrical assemblies that is encountered when attempting to maximize both efficiency of energy transfer and absorption bandwidth. We also rationalize the optimal design strategies and provide explanations for why var...

  4. Postindustrial Architecture, Dynamic Complexity and the Emerging Principles of Strategic Design

    Directory of Open Access Journals (Sweden)

    Leonard Bachman

    2012-11-01

    Full Text Available The transition from industrial era society to postindustrial society has shifted architecture away from being a predominantly cultural activity, one that is primarily focused on the physical attributes of a design. The newer architectural orientation leans more toward social ideals and strategic missions. These two perspectives have always coexisted in the discipline and critique of architecture, but the traditional subjugation of strategic concerns is eroding. The two aspects should now be considered in a more explicitly unified and mindful way. In that sense, the transition is not between two factions of practitioners with different philosophies, but between two aspects of thought balanced in some manner by each architect. The ultimate intentions of this paper are first to examine the forces of postindustrial change and then to outline a set of principles which establish strategic design as an architectural activity tantamount to, compatible with, and discursively engaged by physical design.

  5. Message Design for Mobile Learning: Learning Theories, Human Cognition and Design Principles

    Science.gov (United States)

    Wang, Minjuan; Shen, Ruimin

    2012-01-01

    The demands of an increasingly knowledge-based society and the dramatic advances in mobile phone technology are combining to spur the growth of mobile learning (mLearning). However, for mLearning to attain its full potential, it is essential to develop pedagogy and instructional design tailored to the needs of this new learning environment. At…

  6. NMR quantum computing: applying theoretical methods to designing enhanced systems.

    Science.gov (United States)

    Mawhinney, Robert C; Schreckenbach, Georg

    2004-10-01

    Density functional theory results for chemical shifts and spin-spin coupling constants are presented for compounds currently used in NMR quantum computing experiments. Specific design criteria were examined and numerical guidelines were assessed. Using a field strength of 7.0 T, protons require a coupling constant of 4 Hz with a chemical shift separation of 0.3 ppm, whereas carbon needs a coupling constant of 25 Hz for a chemical shift difference of 10 ppm, based on the minimal coupling approximation. Using these guidelines, it was determined that 2,3-dibromothiophene is limited to only two qubits; the three qubit system bromotrifluoroethene could be expanded to five qubits and the three qubit system 2,3-dibromopropanoic acid could also be used as a six qubit system. An examination of substituent effects showed that judiciously choosing specific groups could increase the number of available qubits by removing rotational degeneracies in addition to introducing specific conformational preferences that could increase (or decrease) the magnitude of the couplings. The introduction of one site of unsaturation can lead to a marked improvement in spectroscopic properties, even increasing the number of active nuclei.

  7. PRINCIPLES OF DESIGNING THE CENTER FOR ADMINISTRATIVE SERVICES IN DNIPROPETROVS’K

    Directory of Open Access Journals (Sweden)

    PODOLYNNY S. I.

    2016-01-01

    Full Text Available Problem. Nowadays providing administrative services of good quality is considered to be one of the most important conditions for establishing firm and democratic relations between local authorities and population The work for creating municipal institutions using the principle of a "single window" is being fulfilled in Dnipropetrovs’k. Two pilot projects have been done at the Department of Architectural Engineering and Design (Prydniprovs’ka State Academy of Construction and Architecture. Objective. To demonstrate peculiarities of two project proposals for CAS comparing them with the recommendations of State Administration and basic principles formed while designing similar objects in foreign practice. Main part. Basic principles for creating the Center for Administrative Services (CAS were formulated regarding foreign experience and recommendations of State Administration. These principles are organized as three conceptual blocks: city-planning relevancy, functional arrangement, form making and artistic image peculiarities. CAS on the left bank of the river is situated on the territory that is being reconstructed at the moment. It is a functional and compositional landmark of social and administrative subcentre of the left bank. The Centre is designed in a 16-storey building with a build-in and build-on 2-floor block of the front-office. The front-office is designed for 121 working places and the back-office – for 440 ones. The general area of the front-office is 605 sq. m., the area of the back-office is 2130 sq. m. Artistic characteristics are designed according to traditional office planning schemes. CAS of the right bank is planned on a vacant site on Zaporiz’ke highway. Spacious parking lots are also provided on the territory. The building is positioned sideways on to the highway with its long axis. It can serve as a peculiar sign at the entrance to the city. The front-office is situated in a two-floor stylobate of the Center

  8. Integration of Instructional Design Principles to Online Courses and Faculty Training in Three Puerto Rican Institutions of Higher Education

    Science.gov (United States)

    Perez, Wanda W.

    2011-01-01

    Research on how the principles of instructional design are taught in faculty training courses for online teaching and how faculty members incorporate these principles into their online courses is limited. This gap in the research literature is especially pronounced when considering the relatively new online learning context of Puerto Rico's higher…

  9. From First Principles Design to Realization of Bimetallic Catalysts for Enhanced Selectivity

    Energy Technology Data Exchange (ETDEWEB)

    Lobo, Raul F.; Crooks, Richard M.; Mavrikakis, Manos

    2014-04-08

    “Catalysis by design” has been a dream for decades. To specify the composition and structure of matter to effect a desired catalytic transformation with desired and predicted rate and selectivity remains a monumental challenge, especially in heterogeneous catalysis. Our research thrusts have been chosen not only for their practical and scientific relevance, e.g. for more efficient and sustainable chemicals and fuels production, but also because they provide a foundation for developing and exploring broadly applicable principles and strategies for catalyst design.

  10. Maximum-principle-satisfying space-time conservation element and solution element scheme applied to compressible multifluids

    KAUST Repository

    Shen, Hua

    2016-10-19

    A maximum-principle-satisfying space-time conservation element and solution element (CE/SE) scheme is constructed to solve a reduced five-equation model coupled with the stiffened equation of state for compressible multifluids. We first derive a sufficient condition for CE/SE schemes to satisfy maximum-principle when solving a general conservation law. And then we introduce a slope limiter to ensure the sufficient condition which is applicative for both central and upwind CE/SE schemes. Finally, we implement the upwind maximum-principle-satisfying CE/SE scheme to solve the volume-fraction-based five-equation model for compressible multifluids. Several numerical examples are carried out to carefully examine the accuracy, efficiency, conservativeness and maximum-principle-satisfying property of the proposed approach.

  11. Environmental risk and the precautionary principle. “Late lessons from early warnings” applied to genetically modified plants

    OpenAIRE

    Aslaksen, Iulie; Natvig, Bent; Nordal, Inger

    2004-01-01

    Abstract: The environmental risk associated with genetically modified organisms (GMO) implies that new approaches to risk assessment, risk management and risk communication are needed. In this paper we discuss the role of the precautionary principle in policy responses to GMO risk. We first discuss application of the criteria in the European Environment Agency report “Late lessons from early warnings: The precautionary principle 1896-2000” to environmental GMO risk, with focus ...

  12. Chemical Frustration. A Design Principle for the Discovery of New Complex Alloy and Intermetallic Phases, Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Fredrickson, Daniel C [Univ. of Wisconsin, Madison, WI (United States)

    2015-06-23

    Final technical report for "Chemical Frustration: A Design Principle for the Discovery of New Complex Alloy and Intermetallic Phases" funded by the Office of Science through the Materials Chemistry Program of the Office of Basic Energy Sciences.

  13. Applying Universal Instructional Design to Course Websites by Using Course Evaluations

    Science.gov (United States)

    Carter, Irene; Leslie, Donald; Kwan, Denise

    2012-01-01

    The authors explore their use of learner-centred teaching strategies and Universal Instructional Design (UID) on course websites. UID is based on universal design, the design of products and environments intended to be usable by all people to the greatest extent possible (Burgstahler & Cory, 2008). UID applies universal design to instructional…

  14. Applying Software Engineering Methodology for Designing Biomedical Software Devoted To Electronic Instrumentation

    Directory of Open Access Journals (Sweden)

    Alderico Rodrigues de Paula Junior

    2012-01-01

    Full Text Available Problem statement: Significant effort goes into the development of biomedical software, which is integrated with computers/processors, sensors and electronic instrumentation devoted to a specific application. However, the scientific work on electronic instrumentation controlled by biomedical software has not emphasized software development, instead focusing mainly on electronics engineering. The development team is rarely composed of Software Engineering (SE experts. Usually, a commercial automated tools environment is not used due to its high cost and complexity for researchers from other areas to understand. Approach: This present study reports how the SE approach was applied to design and develop biomedical software, which is part of a Computerized Electronic Instrumentation (CEI. This CEI comprises software and an electronic instrumentation based on a force sensor and electrogoniometer to monitor the hand exertion of computer user during typing task. The aim is to serve as a guideline for academic researchers who are not expert in software engineering methodology but usually develop their own software to run with their CEI. The specification of the requirements, presented as use case, includes the context diagram, the data flow diagram, the entity relationship diagram and test procedure. The Unified Modelling Language from the Enterprise Architect tool was used. The developed software and the electronic instrumentation were tested together. Results: A sample of the interface screen shows how the outcomes could be plotted in an integrated manner. By comparing the values with other values obtained by manual calculations and with those provided by sensor manufacturer, the repeatability of test procedure validated the results. Reliable electronic instrumentation when working with unreliable software can become unreliable. Conclusion: Applying software engineering methodology principles provided a simple and clear documentation that was helpful

  15. Applications of electromagnetic principles in the design and development of proximity wireless sensors

    Science.gov (United States)

    Alam, Md Nazmul

    Sensors and sensing system are playing dominant roles in monitoring the health of infrastructure, such as bridges, power lines, gas pipelines, rail roads etc. Sensing modalities employing Surface Acoustic Waves (SAW), Electromagnetic (EM) and optical have been investigated and reported. Sensors that utilize the perturbation of EM fields as function of the change in the physical structural or material phenomenon are of particular interest because of their inherent synergy with electronic system and diagnostic techniques, e.g. Time Domain Reflectometry (TDR), Joint-Time-Frequency-Domain-Reflectometry (JTFDR). The focus of this work is to study and develop new sensing and monitoring concepts that are based on EM principles. First, the analyses, design and development of a static electric field type sensor are presented for application in embedded concrete moisture content measurement. The analytical formulation and results based on conformal mapping method for an interdigitated sensor clearly show the dependency of the field penetration depth and the inter-electrode capacitance on the electrode sizes and their spacings. It is observed that larger electrode size and small separation are needed in order to achieve substantially higher capacitance or large field penetration depth. A meander and a circular sensor are fabricated and tested to demonstrate concrete moisture content measurements that show that moisture content is a linear function of sensor interelectrode capacitance. Second, sub-wavelength dimension non-intrusive wave launchers are designed and tested that can launch TDR or JTFDR type broadband surface wave waveforms in the VHF-UHF bands in order to detect cable faults. Greater than 3:1 transmission bandwidth (100-300 MHz) is obtained with a cylindrical launcher on square orthogonal ground plane while with a CSW launcher more than an octave (100-240 MHz) bandwidth is achieved. Open circuit faults are detected using surface waves and TDR on two XLPE cables

  16. Interaction Analysis and Decomposition Principle for Control Structure Design of Large-scale Systems

    Institute of Scientific and Technical Information of China (English)

    罗雄麟; 刘雨波; 许锋

    2014-01-01

    Industrial processes are mostly large-scale systems with high order. They use fully centralized control strategy, the parameters of which are difficult to tune. In the design of large-scale systems, the decomposition ac-cording to the interaction between input and output variables is the first step and the basis for the selection of con-trol structure. In this paper, the decomposition principle of processes in large-scale systems is proposed for the de-sign of control structure. A new variable pairing method is presented, considering the steady-state information and dynamic response of large-scale system. By selecting threshold values, the related matrix can be transformed into the adjoining matrixes, which directly measure the couple among different loops. The optimal number of controllers can be obtained after decomposing the large-scale system. A practical example is used to demonstrate the validity and feasibility of the proposed interaction decomposition principle in process large-scale systems.

  17. Design principle for absorption enhancement with nanoparticles in thin-film silicon solar cells

    International Nuclear Information System (INIS)

    The use of nanoparticles in solar cells has created many controversies. In this paper, different mechanisms of nanoparticles with different materials with diameters varying from 50 to 200 nm, surface coverage at 5, 20, and 60 %, and different locations are analyzed systematically for efficient light trapping in a thin-film c-Si solar cell. Mie theory and the finite difference time domain method are used for analysis to give a design principle with nanoparticles for the solar cell application. Metals exhibit plasmonic resonances and angular scattering, while dielectrics show anti-reflection and scattering in the incident direction. A table is given to summarize the advantages and disadvantages in different conditions. The silicon absorption enhancement with nanoparticles on top is mainly in the shorter wavelengths below 700 nm, and both Al and SiO2 nanoparticles with diameter around 100 nm show the most significant enhancement. The silicon absorption enhancement with embedded nanoparticles takes place in the longer wavelengths over 700 nm, and Ag and SiO2 nanoparticles with larger diameter around 200 nm perform better. However, the light absorbed by Ag nanoparticles will be converted to heat and will lead to decrease in cell efficiency; hence, the choice of metallic nanoparticles in applications to solar cells should be carefully considered. The design principle proposed in this work gives a guideline by choosing reasonable parameters for the different requirements in the application of thin-film solar cells

  18. Design principles for CANDU control centres in response to evolving utility business needs

    International Nuclear Information System (INIS)

    Nuclear generation operators are facing a challenging business environment at the beginning of the new millennium. Evolving changes in business context, competitive commercial pressures, and changes in technology have dictated recurring evaluation of operational practices and the adequacy of supporting tools, and the pursuit of opportunities for operational improvement. A key area of utility operations that has been impacted by these changes is the nuclear plant control centre. Changes to workspace layout, equipment provisions, staffing, and work organization are examples of some of the adjustments being introduced to improve operational and safety effectiveness. This paper discusses some of the key factors influencing these changes and identifies additional design principles for CANDU control centres that will enable new control centre designs and retrofits of existing control centres to remain relevant and responsive to utility needs. (author)

  19. A biosensor based on graphene nanoribbon with nanopores: a first-principles devices-design

    Institute of Scientific and Technical Information of China (English)

    Ouyang Fang-Ping; Peng Sheng-Lin; Zhang Hua; Weng Li-Bo; Xu Hui

    2011-01-01

    A biosensor device, built from graphene nanoribbons (GNRs) with nanopores, was designed and studied by firstprinciples quantum transport simulation. We have demonstrated the intrinsic transport properties of the device and the effect of different nucleobases on device properties when they are located in the nanopores of GNRs. It was found that the device's current changes remarkably with the species of nucleobases, which originates from their different chemical compositions and coupling strengths with GNRs. In addition, our first-principles results clearly reveal that the distinguished ability of a device's current depends on the position of the pore to some extent. These results may present a new way to read off the nucleobases sequence of a single-stranded DNA (ssDNA) molecule by such GNRs-based device with designed nanopores

  20. 75 FR 80571 - Core Principles and Other Requirements for Designated Contract Markets

    Science.gov (United States)

    2010-12-22

    ...The Commodity Futures Trading Commission (``Commission'' or ``CFTC'') is proposing new rules and amended guidance and acceptable practices to implement the new statutory provisions enacted by Title VII of the Dodd-Frank Wall Street Reform and Consumer Protection Act (``Dodd-Frank Act''). The proposed rules, guidance and acceptable practices, which apply to the designation and operation of......

  1. Biomaterial based modulation of macrophage polarization: a review and suggested design principles

    Directory of Open Access Journals (Sweden)

    Rukmani Sridharan

    2015-07-01

    Full Text Available Macrophages have long been known for their phagocytic capabilities and immune defence; however, their role in healing is being increasingly recognized in recent years due to their ability to polarize into pro-inflammatory and anti-inflammatory phenotypes. Historically, biomaterials were designed to be inert to minimize the host response. More recently, the emergence of tissue engineering and regenerative medicine has led to the design of biomaterials that interact with the host through tailored mechanical, chemical and temporal characteristics. Due to such advances in biomaterial functionality and an improved understanding of macrophage responses to implanted materials, it is now possible to identify biomaterial design characteristics that dictate the host response and contribute to successful tissue integration. Herein, we begin by briefly reviewing macrophage cell origin and the key cytokine/chemokine markers of macrophage polarization and then describe which responses are favorable for both replacement and regenerative biomaterials. The body of the review focuses on macrophage polarization in response to inherent cues directly provided by biomaterials and the consequent cues that result from events related to biomaterial implantation. To conclude, a section on potential design principles for both replacement and regenerative biomaterials is presented. An in depth understanding of biomaterial cues to selectively polarize macrophages may prove beneficial in the design of a new generation of ‘immuno-informed’ biomaterials that can positively interact with the immune system to dictate a favorable macrophage response following implantation.

  2. Impact of first-principles properties of deuterium–tritium on inertial confinement fusion target designs

    International Nuclear Information System (INIS)

    A comprehensive knowledge of the properties of high-energy-density plasmas is crucial to understanding and designing low-adiabat, inertial confinement fusion (ICF) implosions through hydrodynamic simulations. Warm-dense-matter (WDM) conditions are routinely accessed by low-adiabat ICF implosions, in which strong coupling and electron degeneracy often play an important role in determining the properties of warm dense plasmas. The WDM properties of deuterium–tritium (DT) mixtures and ablator materials, such as the equation of state, thermal conductivity, opacity, and stopping power, were usually estimated by models in hydro-codes used for ICF simulations. In these models, many-body and quantum effects were only approximately taken into account in the WMD regime. Moreover, the self-consistency among these models was often missing. To examine the accuracy of these models, we have systematically calculated the static, transport, and optical properties of warm dense DT plasmas, using first-principles (FP) methods over a wide range of densities and temperatures that cover the ICF “path” to ignition. These FP methods include the path-integral Monte Carlo (PIMC) and quantum-molecular dynamics (QMD) simulations, which treat electrons with many-body quantum theory. The first-principles equation-of-state table, thermal conductivities (κQMD), and first principles opacity table of DT have been self-consistently derived from the combined PIMC and QMD calculations. They have been compared with the typical models, and their effects to ICF simulations have been separately examined in previous publications. In this paper, we focus on their combined effects to ICF implosions through hydro-simulations using these FP-based properties of DT in comparison with the usual model simulations. We found that the predictions of ICF neutron yield could change by up to a factor of ∼2.5; the lower the adiabat of DT capsules, the more variations in hydro-simulations. The FP-based properties

  3. The Spatial Vision Tree: A Generic Pattern Recognition Engine- Scientific Foundations, Design Principles, and Preliminary Tree Design

    Science.gov (United States)

    Rahman, Zia-ur; Jobson, Daniel J.; Woodell, Glenn A.

    2010-01-01

    New foundational ideas are used to define a novel approach to generic visual pattern recognition. These ideas proceed from the starting point of the intrinsic equivalence of noise reduction and pattern recognition when noise reduction is taken to its theoretical limit of explicit matched filtering. This led us to think of the logical extension of sparse coding using basis function transforms for both de-noising and pattern recognition to the full pattern specificity of a lexicon of matched filter pattern templates. A key hypothesis is that such a lexicon can be constructed and is, in fact, a generic visual alphabet of spatial vision. Hence it provides a tractable solution for the design of a generic pattern recognition engine. Here we present the key scientific ideas, the basic design principles which emerge from these ideas, and a preliminary design of the Spatial Vision Tree (SVT). The latter is based upon a cryptographic approach whereby we measure a large aggregate estimate of the frequency of occurrence (FOO) for each pattern. These distributions are employed together with Hamming distance criteria to design a two-tier tree. Then using information theory, these same FOO distributions are used to define a precise method for pattern representation. Finally the experimental performance of the preliminary SVT on computer generated test images and complex natural images is assessed.

  4. The spatial vision tree: a generic pattern recognition engine: scientific foundations, design principles, and preliminary tree design

    Science.gov (United States)

    Rahman, Zia-ur; Jobson, Daniel J.; Woodell, Glenn A.

    2010-04-01

    New foundational ideas are used to define a novel approach to generic visual pattern recognition. These ideas proceed from the starting point of the intrinsic equivalence of noise reduction and pattern recognition when noise reduction is taken to its theoretical limit of explicit matched filtering. This led us to think of the logical extension of sparse coding using basis function transforms for both de-noising and pattern recognition to the full pattern specificity of a lexicon of matched filter pattern templates. A key hypothesis is that such a lexicon can be constructed and is, in fact, a generic visual alphabet of spatial vision. Hence it provides a tractable solution for the design of a generic pattern recognition engine. Here we present the key scientific ideas, the basic design principles which emerge from these ideas, and a preliminary design of the Spatial Vision Tree (SVT). The latter is based upon a cryptographic approach whereby we measure a large aggregate estimate of the frequency of occurrence (FOO) for each pattern. These distributions are employed together with Hamming distance criteria to design a two-tier tree. Then using information theory, these same FOO distributions are used to define a precise method for pattern representation. Finally the experimental performance of the preliminary SVT on computer generated test images and complex natural images is assessed.

  5. A New Approach in Design and Operating Principle of Silicone Tactile Sensor

    Directory of Open Access Journals (Sweden)

    Bakri Ali

    2010-01-01

    Full Text Available Problem statement: Research and development in tactile sensor are escalating due to the fact that advanced robot needs to interact with surrounding environments which is very complex, dynamic, uncontrolled and difficult to perceive reliably. Recent research has been focusing in development of new tactile sensor that takes advantage of advances in materials, Micro-Electromechanical Systems (MEMS and semiconductor technology. To date, several basic sensing principles are commonly used in tactile sensor such as capacitive sensor, piezoelectric sensor, inductive sensor, opto-electrical and piezo-resistive sensor. However they are still lack of sensitivity and low dynamic range in sensing the changes of forces in 3 axes and not durable enough to perform in various working environments. Approach: Three different designs of optical tactile sensor was proposed and analyzed. The overall design of the test-rig of the system was presented. The working principle was based on the deformation of the silicone tactile sensor. The deformation image will be transferred through high quality medical fiberscope and will be recorded using a CCD camera. The image will be stored in a computer for further analysis to relate the image with the given forces. These data can be used to control a robotic gripper so that it can perform gently and precisely like human tactile sensing capability but with greater strength and durability in various working environments. Results: The sensor had been designed and an experimental test rig was developed. Initial experiment was carried out to check the potential of this technique. Based on results, there is almost a linear relationship between the forces and the deformation of the tactile sensor. The amount of deformation is calculated based on the analyzed image data. Conclusion: The results of the experiment gave a convincing idea and provide a ground for further research to enhance this system to be an alternative tactile sensor in

  6. Towards quantitative accuracy in first-principles transport calculations: The GW method applied to alkane/gold junctions

    DEFF Research Database (Denmark)

    Strange, Mikkel; Thygesen, Kristian Sommer

    2011-01-01

    The calculation of the electronic conductance of nanoscale junctions from first principles is a long-standing problem in the field of charge transport. Here we demonstrate excellent agreement with experiments for the transport properties of the gold/alkanediamine benchmark system when electron-el...

  7. LGB-Affirmative Cognitive Behavioral Treatment for Social Anxiety: A Case Study Applying Evidence-Based Practice Principles

    Science.gov (United States)

    Walsh, Kate; Hope, Debra A.

    2010-01-01

    Guided by the American Psychological Association's principles of evidence-based practice, this article reviews a single-case treatment outcome study whereby a client characteristic, sexual identity, was integrated into the assessment and treatment of social anxiety symptoms. The case involved a young adult European-American male who presented to a…

  8. USING OF OBJECT-ORIENTED DESIGN PRINCIPLES IN ELECTRIC MACHINES DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    N.N. Zablodskii

    2016-03-01

    Full Text Available Purpose. To develop the theoretical basis of electrical machines object-oriented design, mathematical models and software to improve their design synthesis, analysis and optimization. Methodology. We have applied object-oriented design theory in electric machines optimal design and mathematical modelling of electromagnetic transients and electromagnetic field distribution. We have correlated the simulated results with the experimental data obtained by means of the double-stator screw dryer with an external solid rotor, brushless turbo-generator exciter and induction motor with squirrel cage rotor. Results. We have developed object-oriented design methodology, transient mathematical modelling and electromagnetic field equations templates for cylindrical electrical machines, improved and remade Cartesian product and genetic optimization algorithms. This allows to develop electrical machines classifications models, included not only structure development but also parallel synthesis of mathematical models and design software, to improve electric machines efficiency and technical performance. Originality. For the first time, we have applied a new way of design and modelling of electrical machines, which is based on the basic concepts of the object-oriented analysis. For the first time is suggested to use a single class template for structural and system organization of electrical machines, invariant to their specific variety. Practical value. We have manufactured screw dryer for coil dust drying and mixing based on the performed object-oriented theory. We have developed object-oriented software for design and optimization of induction motor with squirrel cage rotor of AIR series and brushless turbo-generator exciter. The experimental studies have confirmed the adequacy of the developed object-oriented design methodology.

  9. The principles and guidelines for designing long-term agronomic experiments

    Institute of Scientific and Technical Information of China (English)

    Mark; Conyers

    2009-01-01

    Many of the important questions facing farming systems in the world today require long-term studies to provide meaningful information and answers. A long-term agronomic experiment (LTAE) should (1) have long-term objectives; (2) study important soil processes or ecological processes; and (3) be related to the productivity and sustainability of systems. A well established LTAE can provide both insights into how the system operates and foresight into where the system goes. The prerequisites for setting up a LTAE are the secured land, continuous funding and dedicated scientists. A number of principles must be considered carefully when establishing a LTAE, (1) the site must be representative of large areas; (2) the treatments should be simple, but focusing on the big questions; (3) the plots should be large enough to allow subsequent modification of the experiment if this becomes necessary; (4) crop rotations should minimise, wherever possible, the risk of build-up of pests and diseases, and rotational phase should be considered in a rotational experiment; (5) a clearly defined experimental protocol should be developed to ensure data collected is scientifically valid and statistically analysable, but with flexibility to allow essential changes; (6) soil samples, possibly plant samples, should be achieved to provide better answer to the original questions when new, perhaps more accurate analytical techniques are developed, or answer new research questions that were not considered in the original design. The MASTER experiment in Australia was used as a case study to demonstrate how these principles are implemented in practice.

  10. Applying Semiotic Theories to Graphic Design Education: An Empirical Study on Poster Design Teaching

    Science.gov (United States)

    Yang, Chao-Ming; Hsu, Tzu-Fan

    2015-01-01

    The rationales behind design are dissimilar to those behind art. Establishing an adequate theoretical foundation for conducting design education can facilitate scientising design methods. Thus, from the perspectives of the semiotic theories proposed by Saussure and Peirce, we investigated graphic design curricula by performing teaching…

  11. Principles and design of a Zeeman-Sisyphus decelerator for molecular beams

    CERN Document Server

    Fitch, N J

    2016-01-01

    We explore a technique for decelerating molecules using a static magnetic field and optical pumping. Molecules travel through a spatially varying magnetic field and are repeatedly pumped into a weak-field seeking state as they move towards each strong field region, and into a strong-field seeking state as they move towards weak field. The method is time-independent and so is suitable for decelerating both pulsed and continuous molecular beams. By using guiding magnets at each weak field region, the beam can be simultaneously guided and decelerated. By tapering the magnetic field strength in the strong field regions, and exploiting the Doppler shift, the velocity distribution can be compressed during deceleration. We develop the principles of this deceleration technique, provide a realistic design, use numerical simulations to evaluate its performance for a beam of CaF, and compare this performance to other deceleration methods.

  12. Rational design of Nb-based alloys for hydrogen separation: A first principles study

    Directory of Open Access Journals (Sweden)

    Byungki Ryu

    2013-02-01

    Full Text Available We have investigated the effect of alloying metal elements on hydrogen solubility and mechanical integrity of Nb-based alloys, Nb15M1 (where M = Ca–Zn, Ge, using first principles-based calculations. In general, the chemical interaction between the interstitial H and metal is weakened as the alloying element is changed from an early to a late transition metal, leading to lower H solubility and higher resistance to H embrittlement. This effect becomes more pronounced when a smaller alloying element is used due to stronger elastic interaction between interstitial H and metal atoms. These finding may provide scientific basis for rational design of Nb-based hydrogen separation membranes with tailored H solubility to effectively suppress H embrittlement while maintaining excellent hydrogen permeation rate.

  13. Design of a speed meter interferometer proof-of-principle experiment

    Science.gov (United States)

    Gräf, C.; Barr, B. W.; Bell, A. S.; Campbell, F.; Cumming, A. V.; Danilishin, S. L.; Gordon, N. A.; Hammond, G. D.; Hennig, J.; Houston, E. A.; Huttner, S. H.; Jones, R. A.; Leavey, S. S.; Lück, H.; Macarthur, J.; Marwick, M.; Rigby, S.; Schilling, R.; Sorazu, B.; Spencer, A.; Steinlechner, S.; Strain, K. A.; Hild, S.

    2014-11-01

    The second generation of large scale interferometric gravitational wave (GW) detectors will be limited by quantum noise over a wide frequency range in their detection band. Further sensitivity improvements for future upgrades or new detectors beyond the second generation motivate the development of measurement schemes to mitigate the impact of quantum noise in these instruments. Two strands of development are being pursued to reach this goal, focusing both on modifications of the well-established Michelson detector configuration and development of different detector topologies. In this paper, we present the design of the world's first Sagnac speed meter (SSM) interferometer, which is currently being constructed at the University of Glasgow. With this proof-of-principle experiment we aim to demonstrate the theoretically predicted lower quantum noise in a Sagnac interferometer compared to an equivalent Michelson interferometer, to qualify SSM for further research towards an implementation in a future generation large scale GW detector, such as the planned Einstein telescope observatory.

  14. Design of a speed meter interferometer proof-of-principle experiment

    CERN Document Server

    Gräf, C; Bell, A S; Campbell, F; Cumming, A V; Danilishin, S L; Gordon, N A; Hammond, G D; Hennig, J; Houston, E A; Huttner, S H; Jones, R A; Leavey, S S; Lück, H; Macarthur, J; Marwick, M; Rigby, S; Schilling, R; Sorazu, B; Spencer, A; Steinlechner, S; Strain, K A; Hild, S

    2014-01-01

    The second generation of large scale interferometric gravitational wave detectors will be limited by quantum noise over a wide frequency range in their detection band. Further sensitivity improvements for future upgrades or new detectors beyond the second generation motivate the development of measurement schemes to mitigate the impact of quantum noise in these instruments. Two strands of development are being pursued to reach this goal, focusing both on modifications of the well-established Michelson detector configuration and development of different detector topologies. In this paper, we present the design of the world's first Sagnac speed meter interferometer which is currently being constructed at the University of Glasgow. With this proof-of-principle experiment we aim to demonstrate the theoretically predicted lower quantum noise in a Sagnac interferometer compared to an equivalent Michelson interferometer, to qualify Sagnac speed meters for further research towards an implementation in a future genera...

  15. Novel Geometrical Concept of a High Performance Brain PET Scanner Principle, Design and Performance Estimates

    CERN Document Server

    Séguinot, Jacques; Chesi, Enrico Guido; Joram, C; Mathot, S; Weilhammer, P; Chamizo-Llatas, M; Correia, J G; Ribeiro da Silva, M; Garibaldi, F; De Leo, R; Nappi, E; Corsi, F; Dragone, A; Schoenahl, F; Zaidi, H

    2006-01-01

    We present the principle, a possible implementation and performance estimates of a novel geometrical concept for a high resolution positron emission tomograph. The concept, which can for example be implemented in a brain PET device, promisses to lead to an essentially parallax free 3D image reconstruction with excellent spatial resolution and constrast, uniform over the complete field of view. The key components are matrices of long axially oriented scintillator crystals which are read out at both extremities by segmented Hybrid Photon Detectors. We discuss the relevant design considerations for a 3D axial PET camera module, motivate parameter and material choices, and estimate its performance in terms of spatial and energy resolution. We support these estimates by Monte Carlo simulations and in some cases by first experimental results. From the performance of a camera module, we extrapolate to the reconstruction resolution of a 3D axial PET scanner in a semi-analytical way and compare it to an existing state...

  16. Core Principles for Talent Management System and its Impact on Competitive Advantage "Applied Study Cellular Communications Companies in Jordan"

    OpenAIRE

    Mohammad Fathi Almaaitah; Yoshifumi Harada; Mohd Foad Bin Sakdan

    2015-01-01

    The aim of this study is to measure the core principles of talent management system and its impact on competitive advantage in Cellular communications companies in Jordan, The population of the study consisted of Three cellular telecom companies operating in the Jordanian market, the study sample was selected a random sample of employees in administrative levels: top management and middle management and supervisors in cellular communications companies operating in Jordan, and around include (...

  17. Developing an approach for first-principles catalyst design: application to carbon-capture catalysis.

    Science.gov (United States)

    Kulik, Heather J; Wong, Sergio E; Baker, Sarah E; Valdez, Carlos A; Satcher, Joe H; Aines, Roger D; Lightstone, Felice C

    2014-02-01

    An approach to catalyst design is presented in which local potential energy surface models are first built to elucidate design principles and then used to identify larger scaffold motifs that match the target geometries. Carbon sequestration via hydration is used as the model reaction, and three- and four-coordinate sp(2) or sp(3) nitrogen-ligand motifs are considered for Zn(II) metals. The comparison of binding, activation and product release energies over a large range of interaction distances and angles suggests that four-coordinate short Zn(II)-Nsp(3) bond distances favor a rapid turnover for CO2 hydration. This design strategy is then confirmed by computationally characterizing the reactivity of a known mimic over a range of metal-nitrogen bond lengths. A search of existing catalysts in a chemical database reveals structures that match the target geometry from model calculations, and subsequent calculations have identified these structures as potentially effective for CO2 hydration and sequestration. PMID:24508957

  18. Design concepts and principle of operation of the HeartWare ventricular assist system.

    Science.gov (United States)

    Larose, Jeffrey A; Tamez, Daniel; Ashenuga, Michael; Reyes, Carlos

    2010-01-01

    Implantable left ventricular assist devices provide circulatory support for patients at risk of death from refractory, end-stage heart failure. Rotary blood pumps have been designed for increased reliability and smaller size for use in a broader population of patients than the first-generation pulsatile devices. The design concepts and principle of operation of the HeartWare System are discussed. The HeartWare Ventricular Assist System (HVAD) is a small centrifugal flow pump with a displacement volume of 50 ml and an output capacity of 10 L/min. A unique wide-blade impeller is suspended by hybrid passive magnets and hydrodynamic forces. An integrated inflow cannula is inserted into the left ventricle and is held in position by an adjustable sewing ring; the pump is positioned in the pericardial space. The 10-mm outflow graft is anastomosed to the ascending aorta. External system components include the microprocessor-based controller, a monitor, lithium-ion battery packs, alternating current and direct current power adapters, and a battery charger. Physiologic control algorithms are incorporated for safe operation. Preclinical life cycle tests have shown the HVAD to be highly reliable. This system design offers reliability, portability, and ease of use for ambulatory patients. PMID:20559135

  19. Developing an approach for first-principles catalyst design: application to carbon-capture catalysis.

    Science.gov (United States)

    Kulik, Heather J; Wong, Sergio E; Baker, Sarah E; Valdez, Carlos A; Satcher, Joe H; Aines, Roger D; Lightstone, Felice C

    2014-02-01

    An approach to catalyst design is presented in which local potential energy surface models are first built to elucidate design principles and then used to identify larger scaffold motifs that match the target geometries. Carbon sequestration via hydration is used as the model reaction, and three- and four-coordinate sp(2) or sp(3) nitrogen-ligand motifs are considered for Zn(II) metals. The comparison of binding, activation and product release energies over a large range of interaction distances and angles suggests that four-coordinate short Zn(II)-Nsp(3) bond distances favor a rapid turnover for CO2 hydration. This design strategy is then confirmed by computationally characterizing the reactivity of a known mimic over a range of metal-nitrogen bond lengths. A search of existing catalysts in a chemical database reveals structures that match the target geometry from model calculations, and subsequent calculations have identified these structures as potentially effective for CO2 hydration and sequestration.

  20. Extending the generality of leaf economic design principles in the cycads, an ancient lineage.

    Science.gov (United States)

    Zhang, Yong-Jiang; Cao, Kun-Fang; Sack, Lawren; Li, Nan; Wei, Xue-Mei; Goldstein, Guillermo

    2015-04-01

    Cycads are the most ancient lineage of living seed plants, but the design of their leaves has received little study. We tested whether cycad leaves are governed by the same fundamental design principles previously established for ferns, conifers and angiosperms, and characterized the uniqueness of this relict lineage in foliar trait relationships. Leaf structure, photosynthesis, hydraulics and nutrient composition were studied in 33 cycad species from nine genera and three families growing in two botanical gardens. Cycads varied greatly in leaf structure and physiology. Similarly to other lineages, light-saturated photosynthetic rate per mass (Am ) was related negatively to leaf mass per area and positively to foliar concentrations of chlorophyll, nitrogen (N), phosphorus and iron, but unlike angiosperms, leaf photosynthetic rate was not associated with leaf hydraulic conductance. Cycads had lower photosynthetic N use efficiency and higher photosynthetic performance relative to hydraulic capacity compared with other lineages. These findings extend the relationships shown for foliar traits in angiosperms to the cycads. This functional convergence supports the modern synthetic understanding of leaf design, with common constraints operating across lineages, even as they highlight exceptional aspects of the biology of this key relict lineage.

  1. An Analysis of Factors that Inhibit Business Use of User-Centered Design Principles: A Delphi Study

    Science.gov (United States)

    Hilton, Tod M.

    2010-01-01

    The use of user-centered design (UCD) principles has a positive impact on the use of web-based interactive systems in customer-centric organizations. User-centered design methodologies are not widely adopted in organizations due to intraorganizational factors. A qualitative study using a modified Delphi technique was used to identify the factors…

  2. EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA); Scientific Opinion on principles for deriving and applying Dietary Reference Values

    DEFF Research Database (Denmark)

    Tetens, Inge

    This Opinion of the EFSA Panel on Dietetic products, Nutrition, and Allergies (NDA) deals with the general principles for development and application of Dietary Reference Values (DRVs). These quantitative reference values for nutrient intakes for healthy individuals and populations are based...... on health criteria. Derived from DRVs, nutrients goals and recommendations take into account other criteria such as food composition or dietary habits, and may be used for assessment and planning of diets. It is proposed to derive the following DRVs: 1) Population Reference Intakes (PRI), 2) Average...

  3. Ultra-high resolution flat-panel volume CT: fundamental principles, design architecture, and system characterization

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, Rajiv; Brady, Tom [Massachusetts General Hospital, Department of Radiology, Founders House, FND-2-216, Boston, MA (United States); Grasruck, Michael; Suess, Christoph; Schmidt, Bernhard; Stierstorfer, Karl; Popescu, Stefan; Flohr, Thomas [Siemens Medical Solutions, Forchheim (Germany); Bartling, Soenke H. [Hannover Medical School, Department of Neuroradiology, Hannover (Germany)

    2006-06-15

    Digital flat-panel-based volume CT (VCT) represents a unique design capable of ultra-high spatial resolution, direct volumetric imaging, and dynamic CT scanning. This innovation, when fully developed, has the promise of opening a unique window on human anatomy and physiology. For example, the volumetric coverage offered by this technology enables us to observe the perfusion of an entire organ, such as the brain, liver, or kidney, tomographically (e.g., after a transplant or ischemic event). By virtue of its higher resolution, one can directly visualize the trabecular structure of bone. This paper describes the basic design architecture of VCT. Three key technical challenges, viz., scatter correction, dynamic range extension, and temporal resolution improvement, must be addressed for successful implementation of a VCT scanner. How these issues are solved in a VCT prototype and the modifications necessary to enable ultra-high resolution volumetric scanning are described. The fundamental principles of scatter correction and dose reduction are illustrated with the help of an actual prototype. The image quality metrics of this prototype are characterized and compared with a multi-detector CT (MDCT). (orig.)

  4. Design Principles for Earthquake Resistant Buildings and Post Earthquake Study by Structural Engineering Perspectives

    Directory of Open Access Journals (Sweden)

    N.K. Dhapekar

    2012-09-01

    Full Text Available Two major earthquakes hit India in last eight years. The first in Killari (Latur Maharashtra on 30th September 1993(Magnitude 6.4,deaths about 10,000 and the second recently at Bhuj Gujrat on 26th January 2001(Magnitude 8.1,deaths more than 35000.In USA two earthquakes took place one in California on 17th January 1994(Magnitude 6.6,deaths 57 and second in Ciatel near Canada on 1 st March 2001(Magnitude 6.8,death 1.It shows clearly that the damage to structures and loss of life is more in developing countries like India as compared to developed countries like USA,Japan etc. This is due to lack of awareness in adopting Indian Standard codal provisions for earthquake resistant design. It is highly expensive to construct structure 100% earthquake proof. This paper aims to highlight design principles for earthquake resistant buildings which should be compulsorily adopted during the construction. In this paper, post earthquake effects on buildings from structural point of view are also highlighted.

  5. Design principles and field performance of a solar spectral irradiance meter

    Energy Technology Data Exchange (ETDEWEB)

    Tatsiankou, V.; Hinzer, K.; Haysom, J.; Schriemer, H.; Emery, K.; Beal, R.

    2016-08-01

    A solar spectral irradiance meter (SSIM), designed for measuring the direct normal irradiance (DNI) in six wavelength bands, has been combined with models to determine key atmospheric transmittances and the resulting spectral irradiance distribution of DNI under all sky conditions. The design principles of the SSIM, implementation of a parameterized transmittance model, and field performance comparisons of modeled solar spectra with reference radiometer measurements are presented. Two SSIMs were tested and calibrated at the National Renewable Energy Laboratory (NREL) against four spectroradiometers and an absolute cavity radiometer. The SSIMs' DNI was on average within 1% of the DNI values reported by one of NREL's primary absolute cavity radiometers. An additional SSIM was installed at the SUNLAB Outdoor Test Facility in September 2014, with ongoing collection of environmental and spectral data. The SSIM's performance in Ottawa was compared against a commercial pyrheliometer and a spectroradiometer over an eight month study. The difference in integrated daily spectral irradiance between the SSIM and the ASD spectroradiometer was found to be less than 1%. The cumulative energy density collected by the SSIM over this duration agreed with that measured by an Eppley model NIP pyrheliometer to within 0.5%. No degradation was observed.

  6. The Principle of the Micro-Electronic Neural Bridge and a Prototype System Design.

    Science.gov (United States)

    Huang, Zong-Hao; Wang, Zhi-Gong; Lu, Xiao-Ying; Li, Wen-Yuan; Zhou, Yu-Xuan; Shen, Xiao-Yan; Zhao, Xin-Tai

    2016-01-01

    The micro-electronic neural bridge (MENB) aims to rebuild lost motor function of paralyzed humans by routing movement-related signals from the brain, around the damage part in the spinal cord, to the external effectors. This study focused on the prototype system design of the MENB, including the principle of the MENB, the neural signal detecting circuit and the functional electrical stimulation (FES) circuit design, and the spike detecting and sorting algorithm. In this study, we developed a novel improved amplitude threshold spike detecting method based on variable forward difference threshold for both training and bridging phase. The discrete wavelet transform (DWT), a new level feature coefficient selection method based on Lilliefors test, and the k-means clustering method based on Mahalanobis distance were used for spike sorting. A real-time online spike detecting and sorting algorithm based on DWT and Euclidean distance was also implemented for the bridging phase. Tested by the data sets available at Caltech, in the training phase, the average sensitivity, specificity, and clustering accuracies are 99.43%, 97.83%, and 95.45%, respectively. Validated by the three-fold cross-validation method, the average sensitivity, specificity, and classification accuracy are 99.43%, 97.70%, and 96.46%, respectively.

  7. Structural design principles for delivery of bioactive components in nutraceuticals and functional foods.

    Science.gov (United States)

    McClements, David Julian; Decker, Eric Andrew; Park, Yeonhwa; Weiss, Jochen

    2009-06-01

    There have been major advances in the design and fabrication of structured delivery systems for the encapsulation of nutraceutical and functional food components. A wide variety of delivery systems is now available, each with its own advantages and disadvantages for particular applications. This review begins by discussing some of the major nutraceutical and functional food components that need to be delivered and highlights the main limitations to their current utilization within the food industry. It then discusses the principles underpinning the rational design of structured delivery systems: the structural characteristics of the building blocks; the nature of the forces holding these building blocks together; and, the different ways of assembling these building blocks into structured delivery systems. Finally, we review the major types of structured delivery systems that are currently available to food scientists: lipid-based (simple, multiple, multilayer, and solid lipid particle emulsions); surfactant-based (simple micelles, mixed micelles, vesicles, and microemulsions) and biopolymer-based (soluble complexes, coacervates, hydrogel droplets, and particles). For each type of delivery system we describe its preparation, properties, advantages, and limitations. PMID:19484636

  8. Design Principles of the Non-smooth Surface of Bionic Plow Moldboard

    Institute of Scientific and Technical Information of China (English)

    Luquan Ren; Shiqiao Deng; Jingchun Wang; Zhiwu Han

    2004-01-01

    The diverse non-smooth body surfaces to reduce soil adhesion are the evolutional results for the soil animals to fit the adhesive and wet environment and can be used as a biological basis for the design of bionic plow moldboard. The model surfaces for bionic simulation should be taken from soil animal digging organs, on which the soil motion is similar to what is on the surface of moldboard. By analyzing the distribution of non-smooth units on the body surface of the ground beetle jaw and the soil moving stresses, the design principles of the bionic moldboard for the local and the whole moldboard were presented respectively. As well, the effect of soil moving speed on reducing adhesion, the dimensions relationship between soil particles and non-smooth convexes, the relationship between the enveloping surface of non-smooth convexes and the initial smooth surface of the plow body, and the convex types of the sphere coronal and the pangolin scales, etc. were discussed.

  9. How to Present Evidence-Based Usability Design Principles Dedicated to Medication-Related Alerting Systems to Designers and Evaluators? Results from a Workshop.

    Science.gov (United States)

    Marcilly, Romaric; Monkman, Helen; Villumsen, Sidsel; Kaufman, David; Beuscart-Zephir, Marie-Catherine

    2016-01-01

    Medication alerting system use errors and lack of adoption are often attributed to usability issues. Previous work has used evidence from the literature to reveal usability principles specific to medication alerting systems and identify potential consequences of violating these principles. The current study sought to explore how best to convey these principles to designers and evaluators of these systems to facilitate their work. To this aim, a workshop with 19 participants was used to generate ideas and opinions on how to deliver these topic-specific design principles in a way that would be most helpful for them. Participants generated ideas for how (e.g., a collaborative, continuously updated forum) and what (e.g., illustrations, checklists, evidence sources and strength, consequences of violations) information is most useful to disseminate usability principles for medication alerting systems. Participants, especially designers, expressed desire to use these principles in practice and avoid previously documented mistakes and therefore make design and evaluation of these systems more effective and efficient. Those insights are discussed in terms of feasibility and logistical challenges to developing the proposed documentation). To move this work forward, a more collaborative approach of Human Factors specialists in medical informatics is necessary. PMID:27577456

  10. Development of next generation digital flat panel catheterization system: design principles and validation methodology

    Science.gov (United States)

    Belanger, B.; Betraoui, F.; Dhawale, P.; Gopinath, P.; Tegzes, Pal; Vagvolgyi, B.

    2006-03-01

    The design principles that drove the development of a new cardiovascular x-ray digital flat panel (DFP) detector system are presented, followed by assessments of imaging and dose performance achieved relative to other state of the art FPD systems. The new system (GE Innova 2100 IQ TM) incorporates a new detector with substantially improved DQE at fluoroscopic (73%@1μR) and record (79%@114uR) doses, an x-ray tube with higher continuous fluoro power (3.2kW), a collimator with a wide range of copper spectral filtration (up to 0.9mm), and an improved automatic x-ray exposure management system. The performance of this new system was compared to that of the previous generation GE product (Innova 2000) and to state-of-the art cardiac digital x-ray flat panel systems from two other major manufacturers. Performance was assessed with the industry standard Cardiac X-ray NEMA/SCA and I phantom, and a new moving coronary artery stent (MCAS) phantom, designed to simulate cardiac clinical imaging conditions, composed of an anthropomorphic chest section with stents moving in a manner simulating normal coronary arteries. The NEMA/SCA&I phantom results showed the Innova 2100 IQ to exceed or equal the Innova 2000 in all of the performance categories, while operating at 28% lower dose on average, and to exceed the other DFP systems in most of the performance categories. The MCAS phantom tests showed the Innova 2100 IQ to be significantly better (p << 0.05) than the Innova 2000, and significantly better than the other DFP systems in most cases at comparable or lower doses, thereby verifying excellent performance against design goals.

  11. Applying Universal Design to Disability Service Provision: Outcome Analysis of a Universal Design (UD) Audit

    Science.gov (United States)

    Beck, Tanja; Diaz del Castillo, Patricia; Fovet, Frederic; Mole, Heather; Noga, Brodie

    2014-01-01

    This article presents out an outcome analysis of a Universal Design (UD) audit to the various professional facets of a disability service (DS) provider's office on a large North American campus. The context of the audit is a broad campus-wide drive to implement Universal Design for Learning (UDL) in teaching practices. In an effort for…

  12. A Tutorial Design Process Applied to an Introductory Materials Engineering Course

    Science.gov (United States)

    Rosenblatt, Rebecca; Heckler, Andrew F.; Flores, Katharine

    2013-01-01

    We apply a "tutorial design process", which has proven to be successful for a number of physics topics, to design curricular materials or "tutorials" aimed at improving student understanding of important concepts in a university-level introductory materials science and engineering course. The process involves the identification…

  13. Applications of Context-Aware Computing in Hospital Work - Examples and Design Principles

    DEFF Research Database (Denmark)

    Bardram, Jacob Eyvind

    2004-01-01

    -aware computing. We present the design of a context-aware pill container and a context-aware hospital bed, both of which reacts and adapts according to what is happening in their context. The applications have been evaluated in a number of workshop with clinicians and patients. Based on this empirical work......Context-awareness is a key concept in ubiquitous computing, which sometimes seems to be a technology looking for a purpose. In this paper we report on the application of context-aware computing for medical work in hospitals, which has appeared to be a strong case for applying context...

  14. A molecular design principle of lyotropic liquid-crystalline conjugated polymers with directed alignment capability for plastic electronics.

    Science.gov (United States)

    Kim, Bong-Gi; Jeong, Eun Jeong; Chung, Jong Won; Seo, Sungbaek; Koo, Bonwon; Kim, Jinsang

    2013-07-01

    Conjugated polymers with a one-dimensional p-orbital overlap exhibit optoelectronic anisotropy. Their unique anisotropic properties can be fully realized in device applications only when the conjugated chains are aligned. Here, we report a molecular design principle of conjugated polymers to achieve concentration-regulated chain planarization, self-assembly, liquid-crystal-like good mobility and non-interdigitated side chains. As a consequence of these intra- and intermolecular attributes, chain alignment along an applied flow field occurs. This liquid-crystalline conjugated polymer was realized by incorporating intramolecular sulphur-fluorine interactions and bulky side chains linked to a tetrahedral carbon having a large form factor. By optimizing the polymer concentration and the flow field, we could achieve a high dichroic ratio of 16.67 in emission from conducting conjugated polymer films. Two-dimensional grazing-incidence X-ray diffraction was performed to analyse a well-defined conjugated polymer alignment. Thin-film transistors built on highly aligned conjugated polymer films showed more than three orders of magnitude faster carrier mobility along the conjugated polymer alignment direction than the perpendicular direction.

  15. What Can Librarians Learn from Elmo, Sid, and Dora? Applying the Principles of Educational Television to Storytime

    Science.gov (United States)

    Cahill, Maria; Bigheart, Jennifer

    2016-01-01

    Parents and caregivers can maximize children's engagement with educational television programming by co-viewing and discussing concepts and issues during and following episodes, and parents and caregivers can poach ideas and processes from these programs and apply them to their own interactions with children. School librarians might also consider…

  16. Reduction of CO2 and orbital debris: can CO2 emission trading principles be applied to debris reduction?

    Science.gov (United States)

    Orlando, Giovanni; Kinnersley, Mark; Starke, Juergen; Hugel, Sebastian; Hartner, Gloria; Singh, Sanjay; Loubiere, Vincent; Staebler, Dominik-Markus; O'Brien-Organ, Christopher; Schwindt, Stefan; Serreau, Francois; Sharma, Mohit

    In the past years global pollution and the specific situation of global warming changes have been strongly influencing public opinion and thus obliged politicians to initiate/ negotiate in-ternational agreements to control, avoid or at least reduce the impact of CO2 emissions e.g. The Kyoto Protocol (1997) and the International Copenhagen conference on Climate Change (2009). In the orbital debris area the collision between the Iridium33 and Cosmos 2251 satel-lites in 2009 has again pushed to the forefront the discussion of the space pollution by space debris and the increasing risk of critical and catastrophic events during the nominal life time of space objects. It is shown by simulations that for Low Earth Orbits the critical debris situation is already achieved and the existing space objects will probably produce sufficient space debris elements -big enough -to support the cascade effect (Kessler Syndrome). In anal-ogy with CO2 emissions, potential recommendations / regulations to reduce the production of Space Debris or its permanence in orbit, are likely to open new markets involving Miti-gation and Removal of Space Debris. The principle approach for the CO2 emission trading model will be investigated and the applicability for the global space debris handling will be analysed. The major differences of the two markets will be derived and the consequences in-dicated. Potential alternative solutions will be proposed and discussed. For the example of the CO2 emission trading principles within EU and worldwide legal conditions for space debris (national / international laws and recommendations) will be considered as well as the commer-cial approach from the controlled situation of dedicated orders to a free / competitive market in steps. It is of interest to consider forms of potential industrial organisations and interna-tional co-operations to react on a similar architecture for the debris removal trading including incentives and penalties for the different

  17. EQUIP: Implementing chronic care principles and applying formative evaluation methods to improve care for schizophrenia: QUERI Series

    Directory of Open Access Journals (Sweden)

    Chinman Matthew J

    2008-02-01

    Full Text Available Abstract Background This paper presents a case study that demonstrates the evolution of a project entitled "Enhancing QUality-of-care In Psychosis" (EQUIP that began approximately when the U.S. Department of Veterans Affairs' Quality Enhancement Research Initiative (QUERI, and implementation science were emerging. EQUIP developed methods and tools to implement chronic illness care principles in the treatment of schizophrenia, and evaluated this implementation using a small-scale controlled trial. The next iteration of the project, EQUIP-2, was further informed by implementation science and the use of QUERI tools. Methods This paper reports the background, development, results and implications of EQUIP, and also describes ongoing work in the second phase of the project (EQUIP-2. The EQUIP intervention uses implementation strategies and tools to increase the adoption and implementation of chronic illness care principles. In EQUIP-2, these strategies and tools are conceptually grounded in a stages-of-change model, and include clinical and delivery system interventions and adoption/implementation tools. Formative evaluation occurs in conjunction with the intervention, and includes developmental, progress-focused, implementation-focused, and interpretive evaluation. Results Evaluation of EQUIP provided an understanding of quality gaps and how to address related problems in schizophrenia. EQUIP showed that solutions to quality problems in schizophrenia differ by treatment domain and are exacerbated by a lack of awareness of evidence-based practices. EQUIP also showed that improving care requires creating resources for physicians to help them easily implement practice changes, plus intensive education as well as product champions who help physicians use these resources. Organizational changes, such as the addition of care managers and informatics systems, were shown to help physicians with identifying problems, making referrals, and monitoring follow

  18. Design principles for maximizing photovoltage in metal-oxide-protected water-splitting photoanodes.

    Science.gov (United States)

    Scheuermann, Andrew G; Lawrence, John P; Kemp, Kyle W; Ito, T; Walsh, Adrian; Chidsey, Christopher E D; Hurley, Paul K; McIntyre, Paul C

    2016-01-01

    Metal oxide protection layers for photoanodes may enable the development of large-scale solar fuel and solar chemical synthesis, but the poor photovoltages often reported so far will severely limit their performance. Here we report a novel observation of photovoltage loss associated with a charge extraction barrier imposed by the protection layer, and, by eliminating it, achieve photovoltages as high as 630 mV, the maximum reported so far for water-splitting silicon photoanodes. The loss mechanism is systematically probed in metal-insulator-semiconductor Schottky junction cells compared to buried junction p(+)n cells, revealing the need to maintain a characteristic hole density at the semiconductor/insulator interface. A leaky-capacitor model related to the dielectric properties of the protective oxide explains this loss, achieving excellent agreement with the data. From these findings, we formulate design principles for simultaneous optimization of built-in field, interface quality, and hole extraction to maximize the photovoltage of oxide-protected water-splitting anodes.

  19. Cell surface receptors for signal transduction and ligand transport - a design principles study

    Energy Technology Data Exchange (ETDEWEB)

    Shankaran, Harish; Resat, Haluk; Wiley, H. S.

    2007-06-01

    Although many different receptors undergo endocytosis, the system-level design principles that govern the evolution of receptor dynamics are far from fully understood. We have constructed a generalized mathematical model to understand how receptor internalization dynamics encodes receptor function and regulation. Parametric analysis of the response of receptor systems to ligand inputs reveals that receptors can be categorized a being: i) avidity-controlled where the response control depends primarily on the extracelluar ligand capture efficiency, ii) consumption-controlled where the ability to internalize surface-bound ligand is the primary control parameter, and iii) dual-sensitivity where both the avidity and consumption parameters are important. We show that the transferrin and low-density lipoprotein receptors are avidity-controlled, the vitellogenin receptor is consumption-controlled and epidermal growth factor receptor is a dual-sensitivity receptor. Significantly, we show that ligand-induced endocytosis is a mechanism to anhance the accuracy of signaling receptors rather than serving to attenuate signaling. Our analysis reveals that the location of a receptor system in the avidity-consumption parameter space can be used to understand both its function and its regulations.

  20. Structural design principles of complex bird songs: a network-based approach.

    Directory of Open Access Journals (Sweden)

    Kazutoshi Sasahara

    Full Text Available Bird songs are acoustic communication signals primarily used in male-male aggression and in male-female attraction. These are often monotonous patterns composed of a few phrases, yet some birds have extremely complex songs with a large phrase repertoire, organized in non-random fashion with discernible patterns. Since structure is typically associated with function, the structures of complex bird songs provide important clues to the evolution of animal communication systems. Here we propose an efficient network-based approach to explore structural design principles of complex bird songs, in which the song networks--transition relationships among different phrases and the related structural measures--are employed. We demonstrate how this approach works with an example using California Thrasher songs, which are sequences of highly varied phrases delivered in succession over several minutes. These songs display two distinct features: a large phrase repertoire with a 'small-world' architecture, in which subsets of phrases are highly grouped and linked with a short average path length; and a balanced transition diversity amongst phrases, in which deterministic and non-deterministic transition patterns are moderately mixed. We explore the robustness of this approach with variations in sample size and the amount of noise. Our approach enables a more quantitative study of global and local structural properties of complex bird songs than has been possible to date.

  1. PRINCIPLES AND PARAMETER DESIGN FOR AC-DC THREE-DEGREE FREEDOM HYBRID MAGNETIC BEARINGS

    Institute of Scientific and Technical Information of China (English)

    ZHU Huangqiu; XIE Zhiyi; ZHU Dehong

    2006-01-01

    To simplify the mechanical structure, decrease the overall system size of the 3-degree freedom axial-radial magnetic bearings and reduce the manufacturing costs as well as operating costs,an innovated AC-DC 3-degree freedom hybrid magnetic bearing is proposed, which is driven by a DC amplifier in axial direction and a 3-phase power converter in radial directions respectively, and the axial and radial bias magnetic fluxes are provided with a common radial polarized permanent magnet ring. The principle producing magnetic suspension forces is introduced. By using equivalent magnetic circuit method, the calculation formulas of magnetic suspension forces and the mathematics models of the system are deduced. Nonlinearities of suspension forces and cross coupling between different degree freedoms are studied further by calculating the suspension forces at different displacements and control currents to validate the feasibility of the mathematics model. Then based on the mathematics models of the bearing, a control method of this novel bearing is designed. Lastly, the methods on parameter design and calculations of the bearing are presented, and an applicable prototype is simulated to analyze the magnetic path by using finite element analysis. The theory analysis and simulation results have shown that this magnetic bearing incorporates the merits of 3-phase AC drive, permanent magnet flux biased and axial-radial combined control, and reduces overall system size and has higher efficiency and lower cost. This innovated magnetic bearing has a wide application in super-speed and super-precision numerical control machine tools, bearingless motors, high-speed flywheels, satellites, etc.

  2. Design, implementation, and evaluation of principles of writing biomedical research paper course

    Directory of Open Access Journals (Sweden)

    ALI AKBAR NEKOOEIAN

    2013-10-01

    Full Text Available Introduction: Graduate (PhD students in medical sciences, who will form future faculties and investigators in Iran’s Universities of Medical Sciences, are not trained on scientific writing during their training. The present study describes the design, implementation, and evaluation of Principles of Writing Biomedical Research Paper course. Methods: The course, prepared based on an extensive search of the literature and books on writing biomedical research papers, was offered as an elective course to PhD students at Shiraz University of Medical Sciences in the second semester of 2011-2012 academic year. The structure and function of various sections of a paper and publication ethics were discussed in lecture and practical sessions over a period of 12 weeks. The course was then evaluated using a self-designed questionnaire. Results: The majority of students gave the highest score (20 to the content and implementation of all sessions of the course. Moreover, most of them believed that the allotted time to the course was not enough, and suggested that it should be increased to 32 hours (equal to two credits. Also, almost all the participants believed that overall the materials lectured were comprehensive, the practical sessions were important in learning the lectured materials, and the course was useful in advancing their abilities and skills to write papers. Conclusion: The evaluation of the present course showed that it was able to increase the participants’ knowledge of the structure of scientific papers, and enhanced their abilities and skills to write papers. The evaluation was used as a basis to modify the course.

  3. The principles of designing of algorithm for speech synthesis from texts written in Albanian language

    Directory of Open Access Journals (Sweden)

    Agni Dika

    2012-05-01

    Full Text Available The speech synthesis is artificial generation of human speech from written texts. For this purpose, adequate algorithms are designed, which then through relevant programs make it possible to synthesize texts to speech. The process of converting text into speech is also known as Text-To-Speech (TTS system [5]. In this paper are given basic principles to be used when designing a system to synthesize speech in Albanian language from written texts. Currently there are solutions that enable natural speech generation for various world languages. However, unfortunately these are not universal solutions to be used for other languages too, because the volume generated for other languages is incomprehensible and unnatural. For this reason, for every language one should seek solutions that address the specifics of it, always with the aim of generating voice to suit the nature of language. Generating systems that are currently used mainly rely on the use of the concatenation method [6], during which acoustic segments of text files are joined, which are previously digitized and stored as such in a database. For Albanian language, we consider that on the textual part of the database, as basic segments to be used are: the most frequent words, two-letters and letters [4]. However, in a particular part of the database are included various abbreviations, i.e. textual equivalents and their acoustics files, to be used also during the generation of appropriate speech. Whereas, with the aim of synthesizing the various numerical values written in the decimal system, in database were added values, respectively their corresponding sound files, whereby speech is generated for different numbers. The first part of the paper is a brief presentation of the Albanian language [1], respectively of the alphabet used in writing the language and its most frequent words.

  4. Principles of appendage design in robots and animals determining terradynamic performance on flowable ground.

    Science.gov (United States)

    Qian, Feifei; Zhang, Tingnan; Korff, Wyatt; Umbanhowar, Paul B; Full, Robert J; Goldman, Daniel I

    2015-10-08

    Natural substrates like sand, soil, leaf litter and snow vary widely in penetration resistance. To search for principles of appendage design in robots and animals that permit high performance on such flowable ground, we developed a ground control technique by which the penetration resistance of a dry granular substrate could be widely and rapidly varied. The approach was embodied in a device consisting of an air fluidized bed trackway in which a gentle upward flow of air through the granular material resulted in a decreased penetration resistance. As the volumetric air flow, Q, increased to the fluidization transition, the penetration resistance decreased to zero. Using a bio-inspired hexapedal robot as a physical model, we systematically studied how locomotor performance (average forward speed, v(x)) varied with ground penetration resistance and robot leg frequency. Average robot speed decreased with increasing Q, and decreased more rapidly for increasing leg frequency, ω. A universal scaling model revealed that the leg penetration ratio (foot pressure relative to penetration force per unit area per depth and leg length) determined v(x) for all ground penetration resistances and robot leg frequencies. To extend our result to include continuous variation of locomotor foot pressure, we used a resistive force theory based terradynamic approach to perform numerical simulations. The terradynamic model successfully predicted locomotor performance for low resistance granular states. Despite variation in morphology and gait, the performance of running lizards, geckos and crabs on flowable ground was also influenced by the leg penetration ratio. In summary, appendage designs which reduce foot pressure can passively maintain minimal leg penetration ratio as the ground weakens, and consequently permits maintenance of effective locomotion over a range of terradynamically challenging surfaces.

  5. Elution by Le Chatelier's principle for maximum recyclability of adsorbents: applied to polyacrylamidoxime adsorbents for extraction of uranium from seawater.

    Science.gov (United States)

    Oyola, Yatsandra; Vukovic, Sinisa; Dai, Sheng

    2016-05-28

    Amidoxime-based polymer adsorbents have attracted interest within the last decade due to their high adsorption capacities for uranium and other rare earth metals from seawater. The ocean contains an approximated 4-5 billion tons of uranium and even though amidoxime-based adsorbents have demonstrated the highest uranium adsorption capacities to date, they are still economically impractical because of their limited recyclability. Typically, the adsorbed metals are eluted with a dilute acid solution that not only damages the amidoxime groups (metal adsorption sites), but is also not strong enough to remove the strongly bound vanadium, which decreases the adsorption capacity with each cycle. We resolved this challenge by incorporating Le Chatelier's principle to recycle adsorbents indefinitely. We used a solution with a high concentration of amidoxime-like chelating agents, such as hydroxylamine, to desorb nearly a 100% of adsorbed metals, including vanadium, without damaging the metal adsorption sites and preserving the high adsorption capacity. The method takes advantage of knowing the binding mode between the amidoxime ligand and the metal and mimics it with chelating agents that then in a Le Chatelier's manner removes metals by shifting to a new chemical equilibrium. For this reason the method is applicable to any ligand-metal adsorbent and it will make an impact on other extraction technologies. PMID:27117598

  6. CONVEX CONTROLLER DESIGN APPLIED TO AC INDUCTION MOTOR TO SATISFY MULTIPLE SIMULTANEOUS SPECIFICATIONS

    Institute of Scientific and Technical Information of China (English)

    LEE Seung-Ju; SUN Dong; MILLS James K

    2006-01-01

    The application of a closed-loop specification oriented feedback control design method,which addresses the design of controllers to satisfy multiple simultaneous conflicting closed-loop performance specifications is presented. The proposed approach is well suited to the design of controllers which must meet a set of conflicting performance specifications. Gain tuning is central to the design process, however, the tuning process is greatly simplified over that presented by the problem of tuning a PID controller for example. The proposed control method is applied to an AC induction motor, with an inner-loop flux vector controller applied to design a position control system. Experimental results verify the effectiveness of this method.

  7. Shark, new motor design concept for energy saving applied to switched reluctance motor

    Energy Technology Data Exchange (ETDEWEB)

    Tataru Kjaer, A.M.

    2005-07-01

    The aim of this thesis is to document and promote a relatively new concept of designing electrical machine with improved efficiency, without using more or better material. The concept, called Shark, consists in replacing the cylindrical air gap by a non-linear shape obtained by translating specific geometrical pattern on the longitudinal axis of the electrical machine. This shape modification increases the air gap area and thus the energy conversion, taking place in the machine. Whilst other methods of improving the efficiency consider the use of more and/or better magnetic material and/or optimisation of the magnetic circuit of the radial cross-section of the machine, the proposed method makes use of the longitudinal cross-section of the machine. In spite of a few reports claiming the improvement of the efficiency by applying the optimisation of the longitudinal cross-section, none analysis of various air gap shapes and of their influence on the magnetic performance has been reported. Due to a simple geometry, the Switched Reluctance Machine has been selected for demonstration of the Shark principle. Initially, linear and finite element analyses are considered. They provide the basic knowledge of the manner in which various Shark air gap, having different dimensions, influence the energy conversion in the machine. The saturation mechanisms, specific to each Shark profile are analysed and optimum Shark profile and its dimensions are selected for implementation in a demonstration machine. Due to the lack of quick analysis tools, an analytical model of the Shark Switched Reluctance Machine is also proposed in this thesis. This model is conceived by modifying one of the existing models of cylindrical air gap Switched Reluctance Machines, such as to account for the presence of the Shark profiles in the air gap. The calculations are verified by measurement on two demonstration machines, having cylindrical and Shark air gaps. The measurement proved the theory right and

  8. Employing the Principles of Universal Design for Learning to Deconstruct the Greek-Cypriot New National Curriculum

    Science.gov (United States)

    Mavrou, Katerina; Symeonidou, Simoni

    2014-01-01

    The present paper discusses issues related to inclusive education and curricula development based on the principles of universal design for learning (UDL), and it reports on the results of a qualitative content analysis of the new national curriculum (NNC) developed for the public Greek-Cypriot schools in Cyprus. According to the findings, the NNC…

  9. Principles of Course Design for Language Teaching and Its Implications to TEFL Reform in Higher Vocational Colleges

    Institute of Scientific and Technical Information of China (English)

    刘彦臻

    2013-01-01

      Principles of Course Design for Language Teaching by Janice Yalden is a linguistics book for the ESL/EFL teachers and researchers. By briefing and analyzing the contents , some guidelines and methods are found practical and enlightening for the teachers in higher vocational college to develop EFL courses.

  10. Critical Curriculum Design for Blended Learning in Higher Education: The Strategies, Principles and Challenges of Interactive Classroom Management

    Science.gov (United States)

    Kurubacak, Gulsun

    2006-01-01

    The main purpose of this article is to introduce a critical curriculum design approach for bringing curriculum change for Blended Learning in higher education. Furthermore, the strategies, principles and challenges of this approach are also presented. This paper provides a perspective on such serious concerns as whether curriculum change should…

  11. Process simulation during the design process makes the difference: process simulations applied to a traditional design

    NARCIS (Netherlands)

    Traversari, R.; Goedhart, R.; Schraagen, J.M.C.

    2013-01-01

    Objective: The objective is evaluation of a traditionally designed operating room using simulation of various surgical workflows.Background: A literature search showed that there is no evidence for an optimal operating room layout regarding the position and size of an ultraclean ventilation (UCV) ca

  12. Process simulation during the design process makes the difference : Process simulations applied to a traditional design

    NARCIS (Netherlands)

    Traversari, R.; Goedhart, R.; Schraagen, J.M.C.

    2013-01-01

    Objective: The objective is evaluation of a traditionally designed operating room using simulation of various surgical workflows. Background: A literature search showed that there is no evidence for an optimal operating room layout regarding the position and size of an ultraclean ventilation (UCV) c

  13. Applying Instructional Design Theories to Bioinformatics Education in Microarray Analysis and Primer Design Workshops

    Science.gov (United States)

    Shachak, Aviv; Ophir, Ron; Rubin, Eitan

    2005-01-01

    The need to support bioinformatics training has been widely recognized by scientists, industry, and government institutions. However, the discussion of instructional methods for teaching bioinformatics is only beginning. Here we report on a systematic attempt to design two bioinformatics workshops for graduate biology students on the basis of…

  14. Design Principles and Case Study Analysis for Low Impact Development Practices - Green Roofs, Rainwater Harvesting and Vegetated Swales

    OpenAIRE

    Ramesh, Shalini

    2011-01-01

    This thesis on Low Impact Development (LID) Practices provides design guidelines and principles for three important LID practices: green roofs, rainwater harvesting and bioswales. The most important component of the thesis is the qualitative analysis of various case studies based on the LID objectives drawn from the literature review for each LID practice. Through the course of my research, I found that there was no one single source which provided information on the design guidelines acc...

  15. A REVIEW ON USER INTERFACE DESIGN PRINCIPLES TO INCREASE SOFTWARE USABILITY FOR USERS WITH LESS COMPUTER LITERACY

    OpenAIRE

    Ali Darejeh; Dalbir Singh

    2013-01-01

    This article presents a review on how software usability could be increased for users with less computer literacy. The literature was reviewed to extract user interface design principles by identifying the similar problems of this group of users. There are different groups of users with less computer literacy. However, based on the literature three groups of them need special attention from software designers. The first group is elderly users, as users with lack of computer background. The se...

  16. Lean Mission Operations Systems Design - Using Agile and Lean Development Principles for Mission Operations Design and Development

    Science.gov (United States)

    Trimble, Jay Phillip

    2014-01-01

    The Resource Prospector Mission seeks to rove the lunar surface with an in-situ resource utilization payload in search of volatiles at a polar region. The mission operations system (MOS) will need to perform the short-duration mission while taking advantage of the near real time control that the short one-way light time to the Moon provides. To maximize our use of limited resources for the design and development of the MOS we are utilizing agile and lean methods derived from our previous experience with applying these methods to software. By using methods such as "say it then sim it" we will spend less time in meetings and more time focused on the one outcome that counts - the effective utilization of our assets on the Moon to meet mission objectives.

  17. Principles of transistor circuits introduction to the design of amplifiers, receivers and digital circuits

    CERN Document Server

    Amos, S W

    2013-01-01

    Principles of Transistor Circuits: Sixth Edition discusses the principles, concepts, and practices involved integrated circuits. The current edition includes up-to-date circuits, the section on thyristors has been revised to give more information on modern types, and dated information has been eliminated. The book covers related topics such as semiconductors and junction diodes; the principles behind transistors; and common amplifiers. The book also covers bias and DC stabilization; large-signal and small-signal AF amplifiers; DC and pulse amplifiers; sinusoidal oscillators; pulse and sawtooth

  18. Applying the principles of welfare and quality of production in the organic farm of the laying hens

    Directory of Open Access Journals (Sweden)

    Jana Zdechovanová

    2013-07-01

    Full Text Available European Union  banned with Council Directive No. 74/1999/EC use of the conventional battery cages for laying hens in European Union with effect from January 1, 2012. By this time much attention was paid to the assessment of laying hens welfare in the modified breeding system,namely from aspect of behavior and expression fyziological stress. At present are used the enriched cages,   which device is defined by the Code of laying hens living conditions. Quantification of intensity and sequence of the events in different behaviour and a time regime can contribute to knowledge of time spending of the laying hens  in the breeding area and to determining of prioritizing their behavior.The aim of our research was assessment an application of principles laying hens welfare in the farm, their production and egg quality. An object of investigation was ecological farm of laying hens. In the experiment were observed thehousing conditions and nutrition of laying hens in farm, egg production, egg weight at laying hens old 42 weeks and selected indicators of chemical formation of the eggs. In the farm were reared laying hens ISA Brown, which are high-productive and the most   the most widely used in EU. The informations and data on farm, laying hen hall, breeding facility, breeding conditions, the behavior of the laying hens, nutrition, feeding and egg production were obtained by personal visit an organic farm and informations which  the farmer records and stores. The informations about the behavior of laying hens were obtained by observing and comparing with the knowledge and data of the Slovak Government regulation on December 11, 2002, which   minimum standards determine for the protection of laying hens.The informations on feed were obtained  directly from an organic farm and   feed company that followed by accordance  the minimum content of nutrients and energy in accordance with the needs of the laying hens. Egg production was

  19. Cell surface receptors for signal transduction and ligand transport: a design principles study.

    Directory of Open Access Journals (Sweden)

    Harish Shankaran

    2007-06-01

    Full Text Available Receptors constitute the interface of cells to their external environment. These molecules bind specific ligands involved in multiple processes, such as signal transduction and nutrient transport. Although a variety of cell surface receptors undergo endocytosis, the systems-level design principles that govern the evolution of receptor trafficking dynamics are far from fully understood. We have constructed a generalized mathematical model of receptor-ligand binding and internalization to understand how receptor internalization dynamics encodes receptor function and regulation. A given signaling or transport receptor system represents a particular implementation of this module with a specific set of kinetic parameters. Parametric analysis of the response of receptor systems to ligand inputs reveals that receptor systems can be characterized as being: i avidity-controlled where the response control depends primarily on the extracellular ligand capture efficiency, ii consumption-controlled where the ability to internalize surface-bound ligand is the primary control parameter, and iii dual-sensitivity where both the avidity and consumption parameters are important. We show that the transferrin and low-density lipoprotein receptors are avidity-controlled, the vitellogenin receptor is consumption-controlled, and the epidermal growth factor receptor is a dual-sensitivity receptor. Significantly, we show that ligand-induced endocytosis is a mechanism to enhance the accuracy of signaling receptors rather than merely serving to attenuate signaling. Our analysis reveals that the location of a receptor system in the avidity-consumption parameter space can be used to understand both its function and its regulation.

  20. Workspace design for crane cabins applying a combined traditional approach and the Taguchi method for design of experiments.

    Science.gov (United States)

    Spasojević Brkić, Vesna K; Veljković, Zorica A; Golubović, Tamara; Brkić, Aleksandar Dj; Kosić Šotić, Ivana

    2016-01-01

    Procedures in the development process of crane cabins are arbitrary and subjective. Since approximately 42% of incidents in the construction industry are linked to them, there is a need to collect fresh anthropometric data and provide additional recommendations for design. In this paper, dimensioning of the crane cabin interior space was carried out using a sample of 64 crane operators' anthropometric measurements, in the Republic of Serbia, by measuring workspace with 10 parameters using nine measured anthropometric data from each crane operator. This paper applies experiments run via full factorial designs using a combined traditional and Taguchi approach. The experiments indicated which design parameters are influenced by which anthropometric measurements and to what degree. The results are expected to be of use for crane cabin designers and should assist them to design a cabin that may lead to less strenuous sitting postures and fatigue for operators, thus improving safety and accident prevention.