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Sample records for applications bla process

  1. Development of a multiplex PCR system and its application in detection of blaSHV, blaTEM, blaCTX-M-1, blaCTX-M-9 and blaOXA-1 group genes in clinical Klebsiella pneumoniae and Escherichia coli strains.

    Science.gov (United States)

    Ogutu, James O; Zhang, Qingmeng; Huang, Ying; Yan, Huo; Su, Lijie; Gao, Bo; Zhang, Wenli; Zhao, Jizi; Cai, Wenhui; Li, Wenjing; Zhao, Hong; Chen, Yang; Song, Wuqi; Chen, Xiaobei; Fu, Yingmei; Zhang, Fengmin

    2015-12-01

    Resistance to β-lactam antibiotics through β-lactamase production by Enterobacteriaceae continues to burden the health-care sector worldwide. Traditional methods for detection of β-lactamases are time-consuming and labor-intensive and newer methods with varying capabilities continue to be developed. The objective of this study was to develop a multiplex PCR (M-PCR) system for the detection of blaSHV, blaTEM, blaCTX-M-1, blaCTX-M-9 and blaOXA-1 group genes and to apply it in clinical Klebsiella pneumoniae and Escherichia coli strains. To do this, we used group-specific PCR primers in singleplex reactions followed by optimization into multiplex reactions. Specificity and sensitivity of the M-PCR were then evaluated using 58 reference strains before its application to detect bla group genes in 203 clinical Enterobacteriaceae strains. PCR amplicons were sequenced to determine the β-lactamase subtypes. The M-PCR system exhibited 100% specificity and sensitivity. In all, 83.7% of K. pneumoniae and 89.8% of E. coli clinical strains harbored bla group genes with 46.9%, 40.1%, 15.0%, 21.1% and 6.1% of K. pneumoniae having blaSHV, blaTEM, blaCTX-M-1, blaCTX-M-9 and blaOXA-1 group genes, respectively, whereas 12.2%, 77.6%, 22.4%, 36.7% and 8.2% of E. coli had blaSHV, blaTEM, blaCTX-M-1, blaCTX-M-9 and blaOXA-1 group genes, respectively. BlaSHV-1, blaSHV-11, blaSHV-27, blaSHV-33, blaSHV-144, blaTEM-1, blaTEM-135, blaOXA-1, blaCTX-M-3, blaCTX-M-9, blaCTX-M-14, blaCTX-M-15, blaCTX-M-27, blaCTX-M-55, blaCTX-M-65 and blaCTX-M-104 were detected. In conclusion, the M-PCR system was efficient and versatile with an advantage of simultaneously detecting all the targeted bla group genes. Hence, it is a potential candidate for developing M-PCR kits for the screening of these genes for clinical or epidemiological purposes. PMID:26104141

  2. US biosimilar pathway unlikely to be used: developers will opt for a traditional BLA filing.

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    Wiatr, Claudia

    2011-02-01

    In March 2010, the US passed the healthcare reform bill, including The Biologics Price Competition and Innovation Act of 2009, which established an abbreviated Biologic License Application (aBLA) pathway for the approval of biosimilars. The aBLA pathway may never be used. At the "Business of Biosimilars" meeting in Boston in September, developers of both innovator and generic biologics as well as representatives from the scientific, regulatory, and legal communities noted that, because of unclear requirements for clinical data and the need for public disclosure of proprietary data, manufacturers of generic biologics are unlikely to take advantage of the aBLA process, opting instead for a standard Biologic License Application (BLA). The implications of an unusable biosimilars pathway in the US dampen our already soft outlook for biosimilars. Companies will still develop follow-on biologics, but approved compounds will behave as new branded drugs. Biosimilars in the US are therefore not likely to lead to aggressive pricing, but will more likely mirror current situations where several similar biologics are available. For example, the interferon (IFN) β-1a products Avonex® and Rebif®, and Betaseron® (IFN β-1b) have all enjoyed >10% price increases for the last several years in spite of their clinical similarities. inThought reiterates its outlook for generic erosion of a typical biologic that projects a loss of revenue of 30% over 5 years compared to the 90% revenue loss for a typical branded small molecule. PMID:21222498

  3. Detection of blaIMP4 and blaNDM1 harboring Klebsiella pneumoniae isolates in a university hospital in Malaysia

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    Nurul Izzati Hamzan

    2015-03-01

    Full Text Available Background: Antibiotic resistance among Enterobacteriaceae posts a great challenge to the health care service. The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP is attracting significant attention due to its rapid and global dissemination. The infection is associated with significant morbidity and mortality, thus creating challenges for infection control and managing teams to curb the infection. In Southeast Asia, there have been limited reports and subsequent research regarding CRKP infections. Thus, the study was conducted to characterize CRKP that has been isolated in our setting. Methods: A total of 321 K. pneumoniae were included in the study. Each isolate went through an identification process using an automated identification system. Phenotypic characterization was determined using disk diffusion, modified Hodge test, Epsilometer test, and inhibitor combined disk test. Further detection of carbapenemase genes was carried out using polymerase chain reaction and confirmed by gene sequence analysis. Results: All together, 13 isolates (4.05% were CRKP and the majority of them were resistant to tested antibiotics except colistin and tigercycline. Among seven different carbapenemase genes studied (bla KPC, bla IMP, bla SME, bla NDM, bla IMI, bla VIM, and bla OXA, only two, bla IMP4 (1.87% and bla NDM1 (2.18%, were detected in our setting. Conclusion: Evidence suggests that the prevalence of CRKP in our setting is low, and knowledge of Carbapenem-resistant Enterobacteriaceae and CRKP has improved and become available among clinicians.

  4. Relation between blaTEM, blaSHV and blaCTX-M genes and acute urinary tract infections

    Institute of Scientific and Technical Information of China (English)

    Sima Sadat Seyedjavadi; Mehdi Goudarzi; Fattaneh Sabzehali

    2016-01-01

    Objective: To survey the frequency of blaTEM, blaSHV and blaCTX-M genotypes in extended-spectrum b-lactamase (ESBL)-producing Escherichia coli (E. coli) isolated from hospitalized patients with urinary tract infection and the determination of their antibiotic resistance patterns. Methods: During 11-month study, 100 ESBL-producing E. coli were collected from 330 patients who met the definition of urinary tract infection. The phenotypic identification of ESBL was confirmed by double disk synergy test and combined disk diffusion test. In vitro, susceptibility to ESBL isolates than 14 antimicrobial agents was performed by Kirby-Bauer disk diffusion method. The frequency of blaTEM, blaSHV and blaCTX-M ESBL-producing E. coli was assessed by PCR method. Results: The frequency of ESBL-producing E. coli was 40.8%. In vitro, susceptibility to ESBL-producing E. coli showed that the majority of isolates were highly susceptible to amikacin (74%) and imipenem (91%). The rates of resistance to other antibiotics varied from 33% to 96%. Through 100 tested isolates, the prevalence of blaTEM, blaSHV and blaCTX-M genes was determined to be 67%, 45% and 74% respectively. In comparison with other bla genes, the frequency of blaCTX-M was strikingly high. Conclusions: Due to the increase of E. coli with multiple ESBL genes, continuous sur-veillance in order to use appropriate antibiotics and the control of infections is necessary.

  5. Emergence of Klebsiella pneumoniae carrying blaVIM and blaKPC genes

    OpenAIRE

    Meletis, G; Tzampaz, E; Protonotariou, E.; Sofianou, D

    2010-01-01

    A Klebsiella pneumoniae clinical isolate resistant to imipenem was recovered from a wound sample. The patient, a 57-year-old man, underwent a surgical resection of small bowel and sigmoid colon and was treated with multiple courses of antimicrobials. PCR analysis revealed that the clinical isolate was carrying simultaneously blaVIM-1, blaKPC-2, blaSHV and blaTEM genes. The concomitant presence of these genes is alarming and poses therapeutic as well as infection control problems.

  6. Detection of P. aeruginosa harboring bla CTX-M-2, bla GES-1 and bla GES-5, bla IMP-1 and bla SPM-1 causing infections in Brazilian tertiary-care hospital

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    Polotto Milena

    2012-08-01

    Full Text Available Abstract Background Nosocomial infections caused by Pseudomonas aeruginosa presenting resistance to beta-lactam drugs are one of the most challenging targets for antimicrobial therapy, leading to substantial increase in mortality rates in hospitals worldwide. In this context, P. aeruginosa harboring acquired mechanisms of resistance, such as production of metallo-beta-lactamase (MBLs and extended-spectrum beta-lactamases (ESBLs have the highest clinical impact. Hence, this study was designed to investigate the presence of genes codifying for MBLs and ESBLs among carbapenem resistant P. aeruginosa isolated in a Brazilian 720-bed teaching tertiary care hospital. Methods Fifty-six carbapenem-resistant P. aeruginosa strains were evaluated for the presence of MBL and ESBL genes. Strains presenting MBL and/or ESBL genes were submitted to pulsed-field gel electrophoresis for genetic similarity evaluation. Results Despite the carbapenem resistance, genes for MBLs (blaSPM-1 or blaIMP-1 were detected in only 26.7% of isolates. Genes encoding ESBLs were detected in 23.2% of isolates. The blaCTX-M-2 was the most prevalent ESBL gene (19.6%, followed by blaGES-1 and blaGES-5 detected in one isolate each. In all isolates presenting MBL phenotype by double-disc synergy test (DDST, the blaSPM-1 or blaIMP-1 genes were detected. In addition, blaIMP-1 was also detected in three isolates which did not display any MBL phenotype. These isolates also presented the blaCTX-M-2 gene. The co-existence of blaCTX-M-2 with blaIMP-1 is presently reported for the first time, as like as co-existence of blaGES-1 with blaIMP-1. Conclusions In this study MBLs production was not the major mechanism of resistance to carbapenems, suggesting the occurrence of multidrug efflux pumps, reduction in porin channels and production of other beta-lactamases. The detection of blaCTX-M-2,blaGES-1 and blaGES-5 reflects the recent emergence of ESBLs among antimicrobial resistant P. aeruginosa and

  7. 多重PCR检测食源金黄色葡萄球菌nuc、blaZ和mecA基因方法的建立与应用%Multiplex PCR for detection of nuc, blaZ and mecA genes in food-borne Staphylococcus aureus and its application

    Institute of Scientific and Technical Information of China (English)

    刘书亮; 刘冬香; 贾仁勇; 韩新锋

    2010-01-01

    目的 建立快速检测食源金黄色葡萄球菌(Sa)耐热核酸酶基因(nuc)、β-内酰胺酶基因(blaZ)和甲氧西林耐药基因(mecA)的多重PCR方法.方法 根据GenBank Sa的nuc、blaZ和mecA基因序列,设计3对特异性引物,建立鉴定Sa及分析Sa耐β-内酰胺类抗生素三重PCR方法,并对79株食源Sa进行基因检测与表型比较.结果 显示供试Sa中检出nuc、blaZ基因阳性率分别为97.47%、73.42%,mecA基因检出为阴性;nuc基因检出与其表型符合率达97.47%;而blaZ扩增结果与β-内酰胺酶试验、青霉素类敏感试验同时符合率为49.37%,前者与后两者符合率分别为60.76%和75.95%;mecA与耐甲氧西林表型符合率为100%;此次79株食源Sa中无耐甲氧西林Sa.结论 该方法简便、快捷、准确,为食源Sa鉴定和耐药性分子分析提供了参考依据.

  8. The Frequency of blaVIM, blaIMP, blaKPC and blaNDM Carbapenemase Genes in Clinical Isolates of Klebsiella Pneumoniae in Kermanshah Medical Centers

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    A Zare

    2015-11-01

    Full Text Available Background: Carbapenemase genes have been spread among strains of Klebsiella pneumoniae that make them resistant to carbapenems. Hence, the present study aimed to study the prevalence of carbapenmase genes within K. pneumoniae isolates in Kermanshah medical centers. Methods: Sixty isolates of K. pneumoniae were collected and identified using API kit. Then, antibiotic susceptibility of isolates was determined using a disk diffusion method. The carbapenems-resistant isolates were screened for carbapenemases production using the Modified Hodge Test (MHT. The carbapenemase genes of blaVIM, blaIMP, KPC and blaNDM were detected by PCR test . Results: Out of 60 isolates, 4 isolates were resistant to carbapenem antibiotics, but only one isolate was demonstrated to be positive for carbapenemases by MHT phenotypic testing. The gene of blaVIM was detected in three isolates by PCR, though other genes were not found in the isolates. Within the isolates, 6.67% and 100% were resistant to carbapenem and ampicillin, respectively. Conclusion: The study findings revealed that dissemination rate of carbapenemase genes was not reported to be high among isolates of K. pneumoniae in Kermanshah. Only blaVIM gene was probably more frequent than other tested genes. Since most isolates examined in this study were susceptible to carbapenem antibiotics, these antibiotics are still regarded as effective drugs against infections caused by K. pneumoniae.

  9. BlaSTorage: a fast package to parse, manage and store BLAST results

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    Orsini Massimiliano

    2013-01-01

    Full Text Available Abstract Background Large-scale sequence studies requiring BLAST-based analysis produce huge amounts of data to be parsed. BLAST parsers are available, but they are often missing some important features, such as keeping all information from the raw BLAST output, allowing direct access to single results, and performing logical operations over them. Findings We implemented BlaSTorage, a Python package that parses multi BLAST results and returns them in a purpose-built object-database format. Unlike other BLAST parsers, BlaSTorage retains and stores all parts of BLAST results, including alignments, without loss of information; a complete API allows access to all the data components. Conclusions BlaSTorage shows comparable speed of more basic parser written in compiled languages as C++ and can be easily integrated into web applications or software pipelines.

  10. Prevalence of blaTEM , blaSHV and blaCTX-M genes in clinical isolates of Escherichia coli and Klebsiella pneumoniae from Northeast India

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    Arijit Bora

    2014-01-01

    Full Text Available Aim: This study was carried out to determine the presence of blaTEM , blaSHV and blaCTX-M genes in extended-spectrum β-lactamase (ESBL producing Escherichia coli (E. coli and Klebsiella pneumoniae (K. pneumoniae at a tertiary care referral hospital in Northeast India. Materials and Methods: A total of 270 E. coli and 219 K. pneumoniae isolates were recovered during the period between August 2009 and July 2010. Kirby-Bauer disk diffusion method was performed to determine the antibiotic resistance pattern. Screening and phenotypic confirmatory test for ESBL production were performed using standard disc diffusion methods. Each of the initial ESBL screening test isolate was investigated for the presence of blaTEM , blaSHV and blaCTX-M genes via polymerase chain reaction (PCR using gene-specific primers. Results: Phenotypic confirmatory test able to detect ESBL production in 73.58% of E. coli and 67.24% of K. pneumoniae. However, PCR amplification showed the presence of one or more ESBL genes in each of the initial ESBL screening positive isolate. Among three ESBL genotypes, the most prevalent genotype was found to be blaCTX-M in E. coli (88.67% and blaTEM in K. pneumoniae (77.58% ESBL producing isolates. Majority of ESBL producing isolates possess more than one ESBL genes. Conclusion: This study constituted a primer report on high prevalence of blaTEM and blaCTX-M genes in ESBL producing isolates of E. coli and K. pneumoniae and denotes the need of more extensive studies on these antibiotic genes to determine the magnitude of the problem of antibiotic resistance exiting in this locality.

  11. Occurrence of co-existing bla VIM-2 and bla NDM-1 in clinical isolates of Pseudomonas aeruginosa from India

    OpenAIRE

    Paul, Deepjyoti; Dhar (Chanda), Debadatta; Maurya, Anand Prakash; MISHRA, Shweta; Sharma, Gauri Dutt; Chakravarty, Atanu; Bhattacharjee, Amitabha

    2016-01-01

    Background bla VIM-2 harboring Pseudomonas aeruginosa has been reported worldwide and considered as the most prevalent metallo-β-lactamase after NDM which are found horizontally transferable and mostly associated with integron gene cassettes. The present study investigates the genetic background, transmission dynamics as well as stability of bla VIM-2 in clinical isolates of P. aeruginosa harbor bla NDM-1 as well which were collected from October 2012 to September 2013. Methods Two P. aerugin...

  12. Detection of bla KPC-2 in Proteus mirabilis in Brazil

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    Adriane Borges Cabral

    2015-02-01

    Full Text Available INTRODUCTION : Infections caused by Klebsiella pneumoniae carbapenemase (KPC-producing isolates pose a major worldwide public health problem today. METHODS : A carbapenem-resistant Proteus mirabilis clinical isolate was investigated for plasmid profiles and the occurrence of β-lactamase genes. RESULTS : The isolate exhibited resistance to ertapenem and imipenem and was susceptible to meropenem, polymyxin, and tigecycline. Five plasmids were identified in this isolate. DNA sequencing analysis revealed the presence of bla KPC-2 and bla TEM-1 genes. An additional PCR using plasmid DNA confirmed that bla KPC-2 was present in one of these plasmids. Conclusions: We report the detection of bla KPC-2 in P. mirabilis in Brazil for the first time. This finding highlights the continuous transfer of bla KPC between bacterial genera, which presents a serious challenge to the prevention of infection by multidrug-resistant bacteria.

  13. Imipenem-resistant Acinetobacter baumannii carrying the ISAba1-bla OXA-23, 51 and ISAba1-bla ADC-7 genes in Monteria, Colombia

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    Pedro Martínez

    2012-12-01

    Full Text Available The purpose of this study was to identify the genes coding for resistance to ceftazidime and imipenem and describe the molecular epidemiology of A. baumannii strains isolated from a clinical center in Colombia. Twenty isolates of imipenem-resistant A. baumannii from an equal number of patients with nosocomial infections were obtained. Primers were used to amplify genes bla IMP, bla VIM, bla OXA-23, bla OXA-24, bla OXA-58, bla OXA-51 and bla ADC-7. To detect insertion sequences ISAba1/bla OXA-23, ISAba1/bla OXA-51 and ISAba1/bla ADC-7, mapping by PCR using combinations of reverse primers ISAba1 and reverse primers of bla OXA-23, bla OXA-51 and bla ADC-7 were used. The amplification products were purified and cloned into PCR 2.1-TOPO vector and transformed into chemically competent Escherichia coli TOP10. These amplicons were then sequenced. PFGE was performed on DNA of A. baumannii isolates digested with ApaI. Results. The DNA profiles obtained included 9 clusters with, four 2-7 isolates per profile, and 5 single-isolate profiles. Of the 20 isolates resistant to imipenem, 15 carried bla OXA-23 gene, 4 contained ISAba1 upstream of bla OXA-51 gene, and 6 contained ISAba1 upstream of bla OXA-23 gene. Eighteen of these isolates carried the bla ADC-7 gene, with 9 of the isolates having ISAba1 located upstream of this gene. This is the first report of the ISAba1 /ADC-7 associated with OXAs genes in A. baumannii isolates from Colombia.

  14. Presence of blaPER-1 and blaVEB-1 beta-lactamase genes among isolates of Pseudomonas aeruginosa from South West of Iran.

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    Davodian, Elham; Sadeghifard, Nourkhoda; Ghasemian, Abdolmajid; Noorbakhsh, Samileh

    2016-09-01

    Pseudomonas aeruginosa isolates have acquired resistance to antibiotics such as novel beta-lactams. The aim of this study was to investigate the blaPER-1, blaVEB-1, and blaPSE-1 genes among isolates of P. aeruginosa among intensive care unit (ICU) patients. Sixty-five isolates were collected. The antibiotic susceptibility testing and combined disk tests were performed to detect the isolates producing extended spectrum beta-lactamases (ESBLs) among ceftazidime-resistant isolates. Polymerase chain reaction (PCR) amplification of blaPER-1, blaVEB-1, and blaPSE-1 genes was conducted. Ten (15.3%) isolates were ESBL-positive, of which 40% (n=4) belonged to males and 60% (n=6) were collected from females. Moreover, two and one isolates harbored blaPER-1 and blaVEB-1 genes, respectively. PMID:26944896

  15. Detection of extended-spectrum β-lactamases (blaCTX-M-1 and blaTEM in Escherichia coli, Salmonella spp., and Klebsiella pneumoniae isolated from poultry in North Eastern India

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    H. Lalzampuia

    2014-11-01

    Full Text Available Aim: The present study was conducted to record the association of extended spectrum β-lactamases (ESBLs producing enteric bacteria with diarrhea of poultry birds in Mizoram, India. Materials and Methods: Fecal samples were collected from poultry birds with the history of diarrhea from different parts of Mizoram. Samples were processed for isolation and identification of Escherichia coli, Salmonella, and Klebsiella pneumoniae. All the isolates were subjected to antibiotic sensitivity assays. Phenotypically, ESBLs production ability was determined by double discs synergy test (DDST method. ESBLs producing isolates were subjected to polymerase chain reaction (PCR for detection of ESBLs genes. Plasmids were cured by acridine orange. Transfer of resistance from donor to recipient strains was done by in vitro horizontal method. Results: A total of 134 enteric bacteria was isolated, of which 102 (76.12%, 21 (15.67% and 11 (8.21% were E. coli, Salmonella spp. and K. pneumoniae, respectively. By DDST 7 (5.22% isolates (6 E. coli and 1 K. pneumoniae were ESBLs producer. PCR analysis confirmed 5 (3.73% (4 E. coli and 1 K. pneumoniae isolates harboured blaCTX-M-1 gene and/or blaTEM gene. All the isolates were carrying plasmids ranging between 0.9 kb and ~30 kb. Of the 4 isolates positive for blaCTX-M-1 and/or blaTEM, 2 (1.84% were confirmed for blaCTX-M-1 gene in their plasmid. No blaTEM gene was detected from plasmid. The resistance plasmid could not be transferred to the recipient by in vitro horizontal gene transfer method. Conclusion: ESBLs producing enteric bacteria are circulating in poultry in North Eastern Region of India. As poultry is one of the most common food animals in this region, these organisms may enter in human population through them.

  16. Information Processing Theory: Classroom Applications.

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    Slate, John R.; Charlesworth, John R., Jr.

    1989-01-01

    Utilizes the information processing model of human memory to provide teachers with suggestions for improving the teaching-learning process. Briefly explains and specifies applications of major theoretical concepts: attention, active learning, meaningfulness, organization, advanced organizers, memory aids, overlearning, automatically, and…

  17. First Report of bla(IMP-8) in Raoultella planticola.

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    Tseng, Sung-Pin; Wang, Jann-Tay; Liang, Chih-Yuan; Lee, Pei-Shan; Chen, Yee-Chun; Lu, Po-Liang

    2014-01-01

    Two carbapenem-resistant Raoultella planticola clinical isolates were isolated from patients with pneumonia and Port-A catheter-related bacteremia, respectively, in Taiwan. These isolates remained susceptible to fluoroquinolone, aminoglycoside, and colistin. Though the two isolates had the same antibiogram, plasmidic carbapenemase blaIMP-8, class 1 integron cassette (dfrA12-orfF-aadA2), and qnrB2, they had different pulsed-field gel electrophoresis patterns, plasmid sizes, and outer membrane protein loss profiles. To our knowledge, this is the first report of blaIMP-8 found in R. planticola. Interestingly, blaIMP-8 is the most common carbapenemase found in Klebsiella pneumoniae in Taiwan. In the literature, carbapenemase genes in R. planticola in each country were also found in carbapenem-resistant Enterobacteriaceae in the same country.

  18. Worldwide Diversity of Klebsiella pneumoniae That Produce β-Lactamase blaKPC-2 Gene1

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    Cuzon, Gaëlle; Naas, Thierry; Truong, HaVy; Villegas, Maria-Virginia; Wisell, Karin T.; Carmeli, Yehuda; Ana C. Gales; Navon-Venezia, Shiri; Quinn, John P.; Nordmann, Patrice

    2010-01-01

    Klebsiella pneumoniae isolates that produce carbapenemases (KPCs) are rapidly disseminating worldwide. To determine their genetic background, we investigated 16 bla KPC-2-harboring K. pneumoniae isolates from 5 countries. The isolates were multidrug resistant, possessed the bla KPC-2 gene, and differed by additional β-lactamase content. They harbored a naturally chromosome-encoded bla gene (bla SHV-1 [12.5%], bla SHV-11 [68.7%], or bla OKP-A/B [18.8%]) and several acquired and plasmid-encoded...

  19. Detection of Extended Spectrum B-Lactamases in Urinary Isolates of Klebsiella pneumoniae in Relation to BlaSHV , BlaTEM and BlaCTX-M Gene Carriage

    OpenAIRE

    Eftekhar, F; Rastegar, M; Golalipoor, M; MansourSamaei, N

    2012-01-01

    Background Resistance to contemporary broad-spectrum β-lactam antibiotics mediated by extended-spectrum β-lactamases (ESBLs) is increasing worldwide. Klebsiella pneumoniae, an important cause of nosocomial and community acquired urinary tract infections has rapidly become the most common ESBL producing organism. We examined ESBL production in urinary isolates of K. pneumoniae in relation to the presence of bla SHV , bla TEM and bla CTX-M genes. Methods: Antibiotic resistance of 51 clinical is...

  20. Detection of Extended Spectrum Β-Lactamases in Urinary Isolates of Klebsiella Pneumoniae in Relation to BlaSHV, BlaTEM and BlaCTX-M Gene Carriage

    OpenAIRE

    MansourSamaei, N; Eftekhar, F; Golalipoor, M; Rastegar, M

    2012-01-01

    Background: Resistance to contemporary broad-spectrum b-lactam antibiotics mediated by extended-spectrum b-lactamases (ESBLs) is increasing worldwide. Klebsiella pneumoniae, an important cause of nosocomial and community acquired urinary tract infections has rapidly become the most common ESBL producing organism. We examined ESBL production in urinary isolates of K. pneumoniae in relation to the presence of blaSHV, blaTEM and blaCTX-M genes.Methods: Antibiotic resistance of 51 clinical isolat...

  1. The Occurrence of blaCTX-M, blaSHV, and blaTEM Genes in Extended-Spectrum β-Lactamase-Positive Strains of Klebsiella pneumoniae, Escherichia coli, and Proteus mirabilis in Poland

    OpenAIRE

    Ojdana, Dominika; Sacha, Paweł; Wieczorek, Piotr; Czaban, Sławomir; Michalska, Anna; Jaworowska, Jadwiga; Jurczak, Anna; Poniatowski, Bogusław; Tryniszewska, Elżbieta

    2014-01-01

    Bacteria belonging to the Enterobacteriaceae family that produce extended-spectrum β-lactamase (ESBL) enzymes are important pathogens of infections. Increasing numbers of ESBL-producing bacterial strains exhibiting multidrug resistance have been observed. The aim of the study was to evaluate the prevalence of blaCTX-M, blaSHV, and blaTEM genes among ESBL-producing Klebsiella pneumoniae, Escherichia coli, and Proteus mirabilis strains and to examine susceptibility to antibiotics of tested stra...

  2. Two Multiplex Real-Time PCR Assays to Detect and Differentiate Acinetobacter baumannii and Non- baumannii Acinetobacter spp. Carrying blaNDM, blaOXA-23-Like, blaOXA-40-Like, blaOXA-51-Like, and blaOXA-58-Like Genes.

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    Yang, Qiu; Rui, Yongyu

    2016-01-01

    Nosocomial infections caused by Acinetobacter spp. resistant to carbapenems are increasingly reported worldwide. Carbapenem-resistant Acinetobacter (CRA) is becoming a serious concern with increasing patient morbidity, mortality, and lengths of hospital stay. Therefore, the rapid detection of CRA is essential for epidemiological surveillance. Polymerase chain reaction (PCR) has been extensively used for the rapid identification of most pathogens. In this study, we have developed two multiplex real-time PCR assays to detect and differentiate A. baumannii and non-A. baumannii Acinetobacter spp, and common carbapenemase genes, including blaNDM, blaOXA-23-like, blaOXA-40-like, blaOXA-51-like, and blaOXA-58-like. We demonstrate the potential utility of these assays for the direct detection of blaNDM-, blaOXA-23-like-, blaOXA-40-like-, blaOXA-51-like-, and blaOXA-58-like-positive CRA in clinical specimens. Primers were specifically designed, and two multiplex real-time PCR assays were developed: multiplex real-time PCR assay1 for the detection of Acinetobacter baumannii 16S-23S rRNA internal transcribed spacer sequence, the Acinetobacter recA gene, and class-B-metalloenzyme-encoding gene blaNDM; and multiplex real-time PCR assay2 to detect class-D-oxacillinase-encoding genes (blaOXA-23-like, blaOXA-40-like, blaOXA-51-like,and blaOXA-58-like). The assays were performed on an ABI Prism 7500 FAST Real-Time PCR System. CRA isolates were used to compare the assays with conventional PCR and sequencing. Known amounts of CRA cells were added to sputum and fecal specimens and used to test the multiplex real-time PCR assays. The results for target and nontarget amplification showed that the multiplex real-time PCR assays were specific, the limit of detection for each target was 10 copies per 20 μL reaction volume, the assays were linear over six log dilutions of the target genes (r2 > 0.99), and the Ct values of the coefficients of variation for intra- and interassay

  3. Two Multiplex Real-Time PCR Assays to Detect and Differentiate Acinetobacter baumannii and Non- baumannii Acinetobacter spp. Carrying blaNDM, blaOXA-23-Like, blaOXA-40-Like, blaOXA-51-Like, and blaOXA-58-Like Genes.

    Directory of Open Access Journals (Sweden)

    Qiu Yang

    Full Text Available Nosocomial infections caused by Acinetobacter spp. resistant to carbapenems are increasingly reported worldwide. Carbapenem-resistant Acinetobacter (CRA is becoming a serious concern with increasing patient morbidity, mortality, and lengths of hospital stay. Therefore, the rapid detection of CRA is essential for epidemiological surveillance. Polymerase chain reaction (PCR has been extensively used for the rapid identification of most pathogens. In this study, we have developed two multiplex real-time PCR assays to detect and differentiate A. baumannii and non-A. baumannii Acinetobacter spp, and common carbapenemase genes, including blaNDM, blaOXA-23-like, blaOXA-40-like, blaOXA-51-like, and blaOXA-58-like. We demonstrate the potential utility of these assays for the direct detection of blaNDM-, blaOXA-23-like-, blaOXA-40-like-, blaOXA-51-like-, and blaOXA-58-like-positive CRA in clinical specimens. Primers were specifically designed, and two multiplex real-time PCR assays were developed: multiplex real-time PCR assay1 for the detection of Acinetobacter baumannii 16S-23S rRNA internal transcribed spacer sequence, the Acinetobacter recA gene, and class-B-metalloenzyme-encoding gene blaNDM; and multiplex real-time PCR assay2 to detect class-D-oxacillinase-encoding genes (blaOXA-23-like, blaOXA-40-like, blaOXA-51-like,and blaOXA-58-like. The assays were performed on an ABI Prism 7500 FAST Real-Time PCR System. CRA isolates were used to compare the assays with conventional PCR and sequencing. Known amounts of CRA cells were added to sputum and fecal specimens and used to test the multiplex real-time PCR assays. The results for target and nontarget amplification showed that the multiplex real-time PCR assays were specific, the limit of detection for each target was 10 copies per 20 μL reaction volume, the assays were linear over six log dilutions of the target genes (r2 > 0.99, and the Ct values of the coefficients of variation for intra- and

  4. Dissemination of Pseudomonas aeruginosa producing blaIMP-1 and blaVIM-1 in Qazvin and Alborz educational hospitals, Iran

    Directory of Open Access Journals (Sweden)

    Amir Peymani

    2016-01-01

    Full Text Available Background and Objectives: Pseudomonas aeruginosa is a frequent opportunistic pathogen in health care associated infections that is highly resistant to the majority of β-lactams. The aims of this study were to access the antimicrobial susceptibility pattern of P. aeruginosa isolated from educational hospitals of Qazvin and Alborz provinces, to determine the prevalence of metallo-β-lactamase (MBL among carbapenem non-susceptible isolates by combined disk (CD method, and to detect the blaIMP, blaVIM, blaSIM, blaGIM, blaSPM and blaNDM-1-MBL genes.Materials and Methods: In this cross-sectional study, 300 P. aeruginosa isolates were collected from different clinical specimens in two provinces of Qazvin and Alborz hospitals, Iran. After identification of isolates by standard laboratory methods, antimicrobial susceptibility was done against 17 antibiotics according to clinical and laboratory standards institute (CLSI guideline. CD method was carried out for detection of MBLs and the presence of blaIMP, blaVIM, blaSIM, blaGIM, blaNDM-1 and blaSPM-genes was further assessed by PCR and sequencing methods.Results: In this study, 107 (35.66% isolates were non-susceptible to imipenem and/or meropenem among those 56 (52.3% isolates were metallo-β-lactamase producer. Twenty-four of 56 (42.85% MBL-positive isolates were confirmed to be positive for MBL-encoding genes in which 14 (25% and 10 (17.85% isolates carried blaIMP-1 and blaVIM-1 genes either alone or in combination. Three (5.35% isolates carried blaIMP and blaVIM genes, simultaneously.Conclusion: Considering the moderate prevalence and clinical importance of MBL-producing isolates, rapid identification and use of appropriate infection control (IC measures are necessary to prevent further spread of infections by these resistant organisms.Keywords: Pseudomonas aeruginosa, Antibiotic resistance, Metallo-β-lactamase

  5. Successful treatment of a Carbapenem-resistant Klebsiella pneumoniae carrying bla OXA-48 , bla VIM-2 , bla CMY-2 and bla SHV- with high dose combination of imipenem and amikacin.

    Science.gov (United States)

    Hajjej, Zied; Gharsallah, Hedi; Naija, Habiba; Boutiba, Ilhem; Labbene, Iheb; Ferjani, Mustapha

    2016-01-01

    We describe a case of 58-year-old man with septic shock due to Carbapenem-resistant Klebsiella pneumoniae (CR-Kp) bloodstream infections (BSI) who was successfully treated with a high dose association of amikacin and imipenem combined with continuous venovenous hemodiafiltration (CVVHDF). A Klebsiella pneumoniae (Kp) was isolated from the catheter culture and from two blood samples, drawn from the catheter before removal and from a peripheral vein. The Kp was intermediate to Amikacin (MIC = 16 μg/ml) and was resistant to all other antibiotics including Imipenem (MIC = 4 μg/ml), Colistin (MIC = 16 μg/ml) and Tigecycline (MIC = 4 μg/ml) according to the Clinical and Laboratory Standards Institute (CLSI) published in 2011. PCR amplification and sequencing verified the presence of blaOXA-48, blaVIM-2, blaCMY-2 and blaSHV-1 genes. Amikacin was given at a dose of 30 mg/kg (2.5 g) in a 30 min infusion and the dose of imipenem was increased to 1 g every 6 h despite patient's altered renal function (Creatinine Clearance = 25 ml/min). To avoid amikacin nephrotoxicity and to allow the use of high doses of imipenem, continuous venovenous hemodiafiltration (CVVHDF) (blood flow, 200 ml/h; dialysate, 1000 ml/h; ultrafiltrate, 2000 ml/h) was initiated 1 h after the start of the amikacin infusion and continued thereafter. The patient improved hemodynamically and norepinephrine was stopped five days after antibiotherapy adaptation.

  6. Successful treatment of a Carbapenem-resistant Klebsiella pneumoniae carrying bla OXA-48 , bla VIM-2 , bla CMY-2 and bla SHV- with high dose combination of imipenem and amikacin.

    Science.gov (United States)

    Hajjej, Zied; Gharsallah, Hedi; Naija, Habiba; Boutiba, Ilhem; Labbene, Iheb; Ferjani, Mustapha

    2016-01-01

    We describe a case of 58-year-old man with septic shock due to Carbapenem-resistant Klebsiella pneumoniae (CR-Kp) bloodstream infections (BSI) who was successfully treated with a high dose association of amikacin and imipenem combined with continuous venovenous hemodiafiltration (CVVHDF). A Klebsiella pneumoniae (Kp) was isolated from the catheter culture and from two blood samples, drawn from the catheter before removal and from a peripheral vein. The Kp was intermediate to Amikacin (MIC = 16 μg/ml) and was resistant to all other antibiotics including Imipenem (MIC = 4 μg/ml), Colistin (MIC = 16 μg/ml) and Tigecycline (MIC = 4 μg/ml) according to the Clinical and Laboratory Standards Institute (CLSI) published in 2011. PCR amplification and sequencing verified the presence of blaOXA-48, blaVIM-2, blaCMY-2 and blaSHV-1 genes. Amikacin was given at a dose of 30 mg/kg (2.5 g) in a 30 min infusion and the dose of imipenem was increased to 1 g every 6 h despite patient's altered renal function (Creatinine Clearance = 25 ml/min). To avoid amikacin nephrotoxicity and to allow the use of high doses of imipenem, continuous venovenous hemodiafiltration (CVVHDF) (blood flow, 200 ml/h; dialysate, 1000 ml/h; ultrafiltrate, 2000 ml/h) was initiated 1 h after the start of the amikacin infusion and continued thereafter. The patient improved hemodynamically and norepinephrine was stopped five days after antibiotherapy adaptation. PMID:27051575

  7. 7 CFR 1599.4 - Application process.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Application process. 1599.4 Section 1599.4... Application process. (a) An entity seeking to enter into an agreement with FAS shall submit an application, in... would involve the use of sale proceeds or income: (i) The process that the applicant would use to...

  8. Co-Carriage of blaKPC-2 and blaNDM-1 in Clinical Isolates of Pseudomonas aeruginosa Associated with Hospital Infections from India.

    Directory of Open Access Journals (Sweden)

    Deepjyoti Paul

    Full Text Available Global spread of KPC poses to be a serious threat complicating treatment options in hospital settings. The present study investigates the genetic environment of blaKPC-2 among clinical isolates of Pseudomonas aeruginosa from a tertiary referral hospital of India. The study isolates were collected from different wards and clinics of Silchar Medical College and Hospital, India, from 2012-2013. The presence of blaKPC was confirmed by genotypic characterization followed by sequencing. Cloning of the blaKPC-2 gene was performed and the genetic environment of this gene was characterized as well. Transferability of the resistance gene was determined by transformation assay and Southern hybridization. Additionally, restriction mapping was also carried out. Two isolates of P. aeruginosa were found to harbor blaKPC-2, were resistant towards aminoglycosides, quinolone and β-lactam-β-lactamase inhibitor combination. In both the isolates, the resistance determinant was associated with class 1 integron and horizontally transferable. Both the isolates were co-harboring blaNDM-1. The first detection of this integron mediated blaKPC-2 coexisting with blaNDM-1 in P. aeruginosa from India is worrisome, and further investigation is required to track the gene cassette mediated blaKPC-2 in terms of infection control and to prevent the spread of this gene in hospitals as well as in the community.

  9. Rapid and Simultaneous Detection of Genes Encoding Klebsiella pneumoniae Carbapenemase (blaKPC) and New Delhi Metallo-β-Lactamase (blaNDM) in Gram-Negative Bacilli

    OpenAIRE

    Cunningham, Scott A.; Noorie, Tabassum; Meunier, Daniele; Woodford, Neil; Patel, Robin

    2013-01-01

    We present a duplex, real-time PCR assay for detection of Klebsiella pneumoniae carbapenemase (blaKPC) and New Delhi metallo-β-lactamase (blaNDM) genes. Accuracy was assessed with 158 Gram-negative bacillary isolates, including 134 carbapenemase producers. The assay had 100% sensitivity and specificity compared with reference methods and a turnaround time of 90 min.

  10. Epidemic plasmid carrying bla(CTX-M-15 in Klebsiella penumoniae in China.

    Directory of Open Access Journals (Sweden)

    Chao Zhuo

    Full Text Available OBJECTIVE: To investigate the local epidemiology of Klebsiella penumoniae carrying bla(CTX-M-15 in southern China and to characterize the genetic environment of bla(CTX-M-15. METHODS: PCR and DNA sequencing were used to detect and characterize the genetic contexts of bla(CTX-M-15. The clonal relatedness of isolates carrying bla(CTX-M-15 was determined by pulse-field gel electrophoresis. Conjugative plasmids carrying bla(CTX-M-15 were obtained by mating and were further subject to restriction analysis and replicon typing. RESULTS: A total of 47CTX-M-15 ESBL-producing isolates of K. pneumoniae were collected from nine hospitals in China from October 2007 to October 2008. Isolates were clustered into various clonal groups. The local spread of bla(CTX-M-15 was mainly mediated by one major conjugative plasmid as determined by S1-PFGE and restriction analysis. A 90-kb plasmid belonging to incompatible group FII was the major carrier of bla(CTX-M-15 in K. pneumoniae. Except bla(TEM-1, the resistance genes such as bla(SHV, bla(DHA-1, bla(OXA-1, qnrB, qnrS, aac(3-II, and aac(6'-Ib were not found in the plasmid. In the comparing of conjugative gene sequence, it is 100% identical with the plasmid pKF3-94, which was found in K. pneumonia from Zhejiang province of china previously. CONCLUSIONS: bla(CTX-M-15 was prevalent in K. pneumonia of southern China. The dissemination of bla(CTX-M-15 appeared to be due to the horizontal transfer of a 90-kb epidemic plasmid.

  11. Increasing secondary bacterial infections with Enterobacteriaceae harboring blaCTX-M-15 and blaCMY-6 in patients with bronchogenic carcinoma:an emerging point of concern

    Institute of Scientific and Technical Information of China (English)

    Mohammed Shahid; Abida Malik; Rakesh Bhargava

    2011-01-01

    Objective: To look for secondary bacterial infections in bronchogenic carcinoma (BCA) with resistant organisms harboring bla genes considering the paucity of relevant studies. Methods:A total of 137 confirmed cases of BCA and 34 healthy volunteers were studied for the occurrence and prevalence of blaCTX-M and and blaAmpC harboring-enterobacteriaceae. A subset of these patients (n=69) was previously reported for the secondary infection with the Aspergillus species. Bronchoalveolar lavages (BAL) were subjected for bacterial and fungal cultures and the bacterial isolates were screened by multiplex PCRs for the presence of blaCTX-M and blaAmpC. The isolates were also screened for the association of insertion sequence (IS26) by PCR and characterized by RAPD for any clonal relatedness. Results: A total of 143 bacterial isolates were obtained from 137 BAL specimens of BCA patients. The Enterobacteriaceae-isolates were multidrug-resistant showing concomitant resistance to fluoroquinolones and aminoglycosides. Both blaCTX-M and blaAmpC of CIT family were detected in 77.4% and 27.4% isolates, respectively. Sequencing revealed the presence of blaCTX-M-15 and blaCMY-6. Twenty one percent of the isolates were simultaneously harboring blaampC and blaCTX-M-15. IS26 PCR and RAPD typing revealed the presence of diverse bacterial population but no predominant clone was identified. The present study also suggests strong association of aspergillosis with lung cancer and further strengthens the potential use of non-validated serological tests suggested earlier. Conclusions: We emphasize that all patients of bronchogenic carcinoma should also be screened for secondary bacterial infections, along with secondary fungal infections, so as to introduce early and specific antimicrobial therapy and to prevent unwanted deaths.

  12. Spread of Enterobacter cloacae carrying blaNDM-1, blaCTX-M-15, blaSHV-12 and plasmid-mediated quinolone resistance genes in a surgical intensive care unit in Croatia.

    Science.gov (United States)

    Petrosillo, N; Vranić-Ladavac, M; Feudi, C; Villa, L; Fortini, D; Barišić, N; Bedenić, B; Ladavac, R; D'Arezzo, S; Andrašević, A Tambić; Capone, A

    2016-03-01

    The objective of this study was to describe a hospital cluster of NDM-1-producing Enterobacter cloacae infections observed in the surgical intensive care unit (ICU) of a tertiary-care hospital at Pula, Croatia. NDM-1-producing E. cloacae strains isolated from clinical samples were screened by PCR for the presence of carbapenemases. Genetic relatedness of NDM-1-producing E. cloacae strains was determined by multilocus sequence typing (MLST). During the period October 2013 to April 2014, four patients, with overlapping hospital stay in the surgical ICU, developed severe infections caused by E. cloacae demonstrated to produce carbapenemases. According to MLST, all strains belonged to ST133 and were positive by PCR for the blaNDM-1 carbapenemase gene, for blaCTX-M-15 and blaSHV-12 extended-spectrum β-lactamase (ESBL) genes, and for blaTEM-1 and blaOXA-1 narrow-spectrum β-lactamase genes. They were negative for other carbapenemases genes including blaOXA-48, blaVIM and blaKPC as well as for AmpC and the armA and rmtB aminoglycoside resistance genes. All strains were positive for the HI2 replicon, suggesting that an IncHI2 plasmid is likely the plasmid carrying the blaNDM-1 gene. Infection control measures were implemented after the first case although they were not effective in avoiding spread of this organism to other patients in the surgical ICU. In conclusion, the evolving epidemiology of NDM-producing micro-organisms and the interspecies diffusion of this resistance mechanism to emerging pathogens such as E. cloacae necessitate the setting up of strong and urgent joint measures to control the spread of NDM carbapenemase especially in the ICU setting. PMID:27436392

  13. 7 CFR 1499.4 - Application process.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Application process. 1499.4 Section 1499.4... process. (a) An entity seeking to enter into an agreement with CCC shall submit an application, in...) The process that the applicant would use to sell the requested commodities, including steps...

  14. Clinical Performance of Check-Direct CPE, a Multiplex PCR for Direct Detection of bla(KPC), bla(NDM) and/or bla(VIM), and bla(OXA)-48 from Perirectal Swabs.

    Science.gov (United States)

    Lau, Anna F; Fahle, Gary A; Kemp, Margaret A; Jassem, Agatha N; Dekker, John P; Frank, Karen M

    2015-12-01

    We evaluated the clinical performance of Check-Direct CPE for carbapenemase detection directly from 301 perirectal swabs (258 patients) in a nonoutbreak setting. Culture of a PCR-confirmed, carbapenemase-containing organism, or history of colonization with such organism within the previous 2 weeks, was used as the reference standard. Check-Direct CPE demonstrated a sensitivity value, specificity value, positive predictive value (PPV), and negative predictive value (NPV) of 100% (all bla(KPC)), 88%, 21%, and 100%, respectively. False positives accounted for 79% (n = 34) of samples for which a cycle threshold (C(T)) value was reached. Simulated studies to evaluate specimen pooling as an approach to minimize costs showed no difference in C(T) values for pooled groups of three or five that each contained a single specimen spiked with ∼1,500 CFU bla(KPC) Klebsiella pneumoniae; however, the detection rate dropped to 60% at a seeded concentration of ∼150 CFU. When data were pooled, C(T) values for bla(KPC) were higher for heavy-feces-containing than for light-feces-containing liquid-suspended specimens. Furthermore, C(T) values for liquid-suspended specimens were 4 to 5 C(T) values lower (i.e., represented greater sensitivity) than those seen in direct swab analysis. Culture was equivalent to or better than Check-Direct CPE for 13/15 (87%) isolates tested in a limit-of-detection analysis. Detection of a carbapenemase gene at a C(T) cutoff value of ≤35 was culture confirmed in 23/24 (96%) of cases; however, C(T) values of >35 overlapped broadly between culture-positive (n = 21) and culture-negative (n = 36) specimens. Check-Direct CPE will likely prove most useful in high-prevalence areas or in outbreak settings where rapid carbapenemase detection is critical for infection control management. PMID:26338860

  15. Diversity and evolution of blaZ from Staphylococcus aureus and coagulase-negative staphylococci

    DEFF Research Database (Denmark)

    Olsen, John E.; Christensen, Henrik; Aarestrup, Frank Møller

    2006-01-01

    . The localization of blaZ was determined by Southern blotting in 108 isolates. Results: All penicillin-resistant strains carried blaZ and showed a similar organization of blaR1 and blaZ. The blaZ gene was localized to a plasmid in only 16 of the resistant strains. Sixty-nine sequences representing 105 isolates......Objectives: To elucidate the diversity and evolutionary history of plasmid- and chromosomally-located blaZ, to detect indications of frequent exchange of blaZ between human and bovine staphylococci and to estimate the frequency of transfer of blaZ between coagulase-negative staphylococci (Co......NS) and Staphylococcus aureus of bovine origin. Methods: blaZ was detected in 143 strains of penicillin-resistant S. aureus and CoNS from five Danish cattle herds (n = 25/23), random CoNS isolates from Denmark (n = 37), a collection of S. aureus from six different countries (n = 52), humans in Denmark (n = 3) and beta...

  16. Investigation of diversity of plasmids carrying the blaTEM-52 gene

    DEFF Research Database (Denmark)

    Bielak, Eliza Maria; Bergenholtz, Rikke D.; Jørgensen, Mikael Skaanning;

    2011-01-01

    OBJECTIVES: To investigate the diversity of plasmids that carry blaTEM-52 genes among Escherichia coli and Salmonella enterica originating from animals, meat products and humans. METHODS: A collection of 22 blaTEM-52-encoding plasmids was characterized by restriction fragment length polymorphism...... of self-transfer to a plasmid-free E. coli recipient. CONCLUSIONS: The blaTEM-52 gene found in humans could have been transmitted on transferable plasmids originating from animal sources. Some of the blaTEM-52 plasmids carry replicons that differ from the classical ones. Two novel replicons were detected...

  17. Complete sequencing of an IncX3 plasmid carrying blaNDM-5 allele reveals an early stage in the dissemination of the blaNDM gene

    Directory of Open Access Journals (Sweden)

    M Krishnaraju

    2015-01-01

    Full Text Available Purpose: The aim of the present study was to perform molecular characterisation of the blaNDM plasmids and to understand the mechanism of its spread among pathogenic bacteria. Materials and Methods: Seventy-six non-repetitive carbapenem-resistant isolates which were collected during Nov 2011 to April 2013 from four hospitals in Chennai were analyzed for the presence of the blaNDM gene by PCR. Further, the genetic context of the blaNDM gene was analyzed by PCR specific to ISAba125 and bleMBL gene. One of the blaNDM plasmid was completely sequenced in the Illumina HiSeq platform. Results: Twenty-three isolates consisting of 8 Escherichia coli, 8 Klebsiella pneumoniae, 3 Klebsiella oxytoca, 3 Acinetobacter baumanii and 1 Pseudomonas aeruginosa were found to carry the blaNDM gene. In 18 isolates the blaNDM gene was associated with a bleMBL gene and the ISAba125 element. The complete sequencing of pNDM-MGR194 revealed an IncX3 replication type plasmid, with a length of 46,253 bp, an average GC content of 47% and 59 putative ORFs. The iteron region contained the blaNDM5 gene and the bleMBL , trpF and dsbC genes downstream and an IS5 inserted within the ISAba125 element upstream. Conclusion: This is the first report where the blaNDM gene insertion in a plasmid is not accompanied by other resistance gene determinants. These observations suggest that the IncX3 plasmid pNDM-MGR194 is an early stage in the dissemination of the blaNDM .

  18. blaCTX-M,blaTEM, andblaSHV inEnterobacteriaceae from North-Indian tertiary hospital:high occurrence of combination genes

    Institute of Scientific and Technical Information of China (English)

    Mohammed Shahid; Anuradha Singh; Farrukh Sobia; Mohammad Rashid; Abida Malik; Indu Shukla; Haris Manzoor Khan

    2011-01-01

    Objective:To delineate the frequency of occurrence ofblaCTX-M,blaTEM, andblaSHV in Enterobacteriaceae from North-Indian tertiary hospital.Methods: A random collection of a subset of45Escherichia coli (E. coli) and28Klebsiella pneumoniae (K. pneumoniae) that was resistant to a third generation cephalosporin and obtained during2007-2008 was selected for detailed screening forblaCTX-M,blaTEM, andblaSHV by monoplexPCRs. The isolates demonstrating the presence of blaCTX-M alleles were characterized for the specificCTX-M-genogroup by using a multiplexPCR.Results:Resistance to cefoperazone, ceftazidime, ceftriaxone, cefotaxime, cefoxitin and piperacillin was 100% each inK. pneumoniae isolates, whereas these resistance-rates forE. coli isolates were93.1%, 83.8%, 91.9%, 93.6%, 97.3% and97.1%, respectively. Concomitant resistance to aminoglycosides, quinolones and aztreonam was also noticed. Presence of any of the bla genes (blaCTX-M,blaTEM, andblaSHV) was noticed in a total of28 (38.4%) isolates of the73isolates studied. Many isolates demonstrated occurrence of these genes in various combinations.blaCTX-M,blaTEM, andblaSHV were noticed in 28.8%,10.9% and13.7% isolates, respectively. MultiplexPCR inblaCTX-Mharboring isolates demonstrated the presence ofCTX-M-Genogroup-1 and sequencing for the specificCTX-M-type revealed presence ofCTX-M-15 type. RAPD typing showed wide diversity in isolates.Conclusions:This is amongst the premier report describing the simultaneous occurrence ofblaTEM,blaSHV, andblaampC in IndianEnterobacteriaceae and that wider dissemination of these genes, as demonstrated by diversity of isolates, raises concern and emphasizes a need for extensive search for the presence of these gene pools in Indian subcontinent.

  19. 49 CFR 80.7 - Application process.

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    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Application process. 80.7 Section 80.7 Transportation Office of the Secretary of Transportation CREDIT ASSISTANCE FOR SURFACE TRANSPORTATION PROJECTS § 80.7 Application process. (a) Public and private applicants for credit assistance under this...

  20. 49 CFR 262.11 - Application process.

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    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Application process. 262.11 Section 262.11 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... IMPROVEMENT PROJECTS § 262.11 Application process. (a) All grant applications for opportunities funded...

  1. 44 CFR 79.5 - Application process.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Application process. 79.5 Section 79.5 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... § 79.5 Application process. (a) Applicant or grantee. (1) States will be notified of the...

  2. Application of wavelets in speech processing

    CERN Document Server

    Farouk, Mohamed Hesham

    2014-01-01

    This book provides a survey on wide-spread of employing wavelets analysis  in different applications of speech processing. The author examines development and research in different application of speech processing. The book also summarizes the state of the art research on wavelet in speech processing.

  3. GPU applications for data processing

    Energy Technology Data Exchange (ETDEWEB)

    Vladymyrov, Mykhailo, E-mail: mykhailo.vladymyrov@cern.ch [LPI - Lebedev Physical Institute of the Russian Academy of Sciences, RUS-119991 Moscow (Russian Federation); Aleksandrov, Andrey [LPI - Lebedev Physical Institute of the Russian Academy of Sciences, RUS-119991 Moscow (Russian Federation); INFN sezione di Napoli, I-80125 Napoli (Italy); Tioukov, Valeri [INFN sezione di Napoli, I-80125 Napoli (Italy)

    2015-12-31

    Modern experiments that use nuclear photoemulsion imply fast and efficient data acquisition from the emulsion can be performed. The new approaches in developing scanning systems require real-time processing of large amount of data. Methods that use Graphical Processing Unit (GPU) computing power for emulsion data processing are presented here. It is shown how the GPU-accelerated emulsion processing helped us to rise the scanning speed by factor of nine.

  4. Process Neural Networks Theory and Applications

    CERN Document Server

    He, Xingui

    2010-01-01

    "Process Neural Networks - Theory and Applications" proposes the concept and model of a process neural network for the first time, showing how it expands the mapping relationship between the input and output of traditional neural networks, and enhancing the expression capability for practical problems, with broad applicability to solving problems relating to process in practice. Some theoretical problems such as continuity, functional approximation capability, and computing capability, are strictly proved. The application methods, network construction principles, and optimization alg

  5. 45 CFR 12a.9 - Application process.

    Science.gov (United States)

    2010-10-01

    ... the requirements of 45 CFR 12.9. (7) Historic preservation. Where applicable, the applicant must..., as specified in 45 CFR part 12. (c) Scope of evaluations. Due to the short time frame imposed for... 45 Public Welfare 1 2010-10-01 2010-10-01 false Application process. 12a.9 Section 12a.9...

  6. 8 CFR 240.63 - Application process.

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    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Application process. 240.63 Section 240.63 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS PROCEEDINGS TO DETERMINE... Cancellation of Removal Under Section 203 of Pub. L. 105-100 § 240.63 Application process. (a) Form and...

  7. Molecular detection of metallo-β-lactamase genes, blaIMP-1, blaVIM-2 and blaSPM-1 in imipenem resistant Pseudomonas aeruginosa isolated from clinical specimens in teaching hospitals of Ahvaz, Iran

    Directory of Open Access Journals (Sweden)

    Mojtaba Moosavian

    2015-10-01

    Full Text Available Background and Objectives: Carbapenem resistant Pseudomonas aeruginosa is a serious cause of nosocomial infections.The main purpose of the study is to determine the prevalence rate of imipenem resistant Pseudomonas aeruginosa carryingmetallo- beta- lactamase (MBL genes.Material and Methods: 236 Pseudomonas aeruginosa isolates were collected from teaching hospitals of Ahvaz Universityof Medical Sciences during a period of 9 months in 2012. These strains were identified using conventional microbiologicaltests. The susceptibility of isolates to antibiotics were assessed using disk diffusion test. The IMP-EDTA combination diskphenotypic test was performed for detection of MBL producing strains. Finally, polymerase chain reaction (PCR wasperformed to detect MBL genes, blaIMP-1, blaVIM-2 and blaSPM-1 in imipenem resistant strains.Results: Out of 236 examined isolates, 122 isolates (51.4% were resistant to imipenem. The IMP-EDTA combination testshowed that among 122 imipenem resistant strains, 110 strains (90% were phenotipically MBL producers. Additionally, theresults of PCR method showed that 2 strains (1.6% and 67strains (55% of imipenem resistant Pseudomonas aeruginosaisolates contained blaVIM-2 and blaIMP-1 genes respectively. No SPM-1gene was found in the examined samples.Conclusion: Resistance of P. aeruginosa isolates to imipenem due to MBL enzymes is increasing in Ahavaz. Becauseof clinical significance of this kind of resistance, rapid detection of MBL producing strains and followed by appropriatetreatment is necessary to prevent the spreading of these organisms.

  8. Electrospinning Materials, Processing, and Applications

    CERN Document Server

    Wendorff, Joachim H; Greiner, Andreas

    2012-01-01

    Bringing together the world's experts in the field, this book summarizes the state-of-the art in electrospinning with detailed coverage of the various techniques, material systems, and their resulting fiber structures and properties, theoretical aspects, and applications. Throughout the book, the current status of knowledge is introduced with a critical view on accomplishments and novel persepectives. An experimental section gives hands-on guidance to beginners and experts alike.

  9. Process-driven applications with BPMN

    CERN Document Server

    Stiehl, Volker

    2014-01-01

    How can we optimize differentiating business processes and exploit their full potential? Here Volker Stiehl provides answers, utilizing the various options that the BPMN (Business Process Model and Notation) standard offers for planning, implementing and monitoring processes. The book presents an approach for implementing an architecture for applications that strives to find a balance between development and maintenance costs, sustainability, scalability and fault tolerance; that meets flexibility requirements without becoming inordinately complex itself; and that keeps the end application a

  10. Software for parallel processing applications

    International Nuclear Information System (INIS)

    Parallel computing has been used to solve large computing problems in high-energy physics. Typical problems include offline event reconstruction, monte carlo event-generation and reconstruction, and lattice QCD calculations. Fermilab has extensive experience in parallel computing using CPS (cooperative processes software) and networked UNIX workstations for the loosely-coupled problems of event reconstruction and monte carlo generation and CANOPY and ACPMAPS for Lattice QCD. Both systems will be discussed. Parallel software has been developed by many other groups, both commercial and research-oriented. Examples include PVM, Express and network-Linda for workstation clusters and PCN and STRAND88 for more tightly-coupled machines

  11. Ultrasound Applications in Food Processing

    Science.gov (United States)

    Bermúdez-Aguirre, Daniela; Mobbs, Tamara; Barbosa-Cánovas, Gustavo V.

    Food scientists today are focused on the development of not only microbiologically safe products with a long storage life, but, at the same time, products that have fresh-like characteristics and a high quality in taste, flavor, and texture. This focus is based on the needs of the consumer, which is one of the main reasons for constant research in the so-called area of emerging technologies. Traditionally, thermal treatments have been used to produce safe food products. Pasteurization of juice, milk, beer, and wine is a common process in which the final product has a storage life of some weeks (generally under refrigeration). However, vitamins, taste, color, and other sensorial characteristics are decreased with this treatment. High temperature is responsible for these effects and can be observed in the loss of nutritional components and changes in flavor, taste, and texture, often creating the need for additives to improve the product.

  12. Image processing applications in NDE

    Energy Technology Data Exchange (ETDEWEB)

    Morris, R.A.

    1980-01-01

    Nondestructive examination (NDE) can be defined as a technique or collection of techniques that permits one to determine some property of a material or object without damaging the object. There are a large number of such techniques and most of them use visual imaging in one form or another. They vary from holographic interferometry where displacements under stress are measured to the visual inspection of an objects surface to detect cracks after penetrant has been applied. The use of image processing techniques on the images produced by NDE is relatively new and can be divided into three general categories: classical image enhancement; mensuration techniques; and quantitative sensitometry. An example is discussed of how image processing techniques are used to nondestructively and destructively test the product throughout its life cycle. The product that will be followed is the microballoon target used in the laser fusion program. The laser target is a small (50 to 100 ..mu..m - dia) glass sphere with typical wall thickness of 0.5 to 6 ..mu..m. The sphere may be used as is or may be given a number of coatings of any number of materials. The beads are mass produced by the millions and the first nondestructive test is to separate the obviously bad beads (broken or incomplete) from the good ones. After this has been done, the good beads must be inspected for spherocity and wall thickness uniformity. The microradiography of the glass, uncoated bead is performed on a specially designed low-energy x-ray machine. The beads are mounted in a special jig and placed on a Kodak high resolution plate in a vacuum chamber that contains the x-ray source. The x-ray image is made with an energy less that 2 keV and the resulting images are then inspected at a magnification of 500 to 1000X. Some typical results are presented.

  13. Fuzzy image processing and applications with Matlab

    CERN Document Server

    Chaira, Tamalika

    2009-01-01

    In contrast to classical image analysis methods that employ ""crisp"" mathematics, fuzzy set techniques provide an elegant foundation and a set of rich methodologies for diverse image-processing tasks. However, a solid understanding of fuzzy processing requires a firm grasp of essential principles and background knowledge.Fuzzy Image Processing and Applications with MATLAB® presents the integral science and essential mathematics behind this exciting and dynamic branch of image processing, which is becoming increasingly important to applications in areas such as remote sensing, medical imaging,

  14. Radar signal processing and its applications

    CERN Document Server

    Hummel, Robert; Stoica, Petre; Zelnio, Edmund

    2003-01-01

    Radar Signal Processing and Its Applications brings together in one place important contributions and up-to-date research results in this fast-moving area. In twelve selected chapters, it describes the latest advances in architectures, design methods, and applications of radar signal processing. The contributors to this work were selected from the leading researchers and practitioners in the field. This work, originally published as Volume 14, Numbers 1-3 of the journal, Multidimensional Systems and Signal Processing, will be valuable to anyone working or researching in the field of radar signal processing. It serves as an excellent reference, providing insight into some of the most challenging issues being examined today.

  15. Advances in Nuclear Power Process Heat Applications

    International Nuclear Information System (INIS)

    Following an IAEA coordinated research project, this publication compiles the findings of research and development activities related to practical nuclear process heat applications. An overview of current progress on high temperature gas cooled reactors coupling schemes for different process heat applications, such as hydrogen production and desalination is included. The associated safety aspects are also highlighted. The summary report documents the results and conclusions of the project.

  16. Protein engineering of enzymes for process applications

    DEFF Research Database (Denmark)

    Woodley, John M

    2013-01-01

    Scientific progress in the field of enzyme modification today enables the opportunity to tune a given biocatalyst for a specific industrial application. Much work has been focused on extending the substrate repertoire and altering selectivity. Nevertheless, it is clear that many new forthcoming...... opportunities will be targeted on modification to enable process application. This article discusses the challenges involved in enzyme modification focused on process requirements, such as the need to fulfill reaction thermodynamics, specific activity under the required conditions, kinetics at required...

  17. Digital signal processing techniques and applications in radar image processing

    CERN Document Server

    Wang, Bu-Chin

    2008-01-01

    A self-contained approach to DSP techniques and applications in radar imagingThe processing of radar images, in general, consists of three major fields: Digital Signal Processing (DSP); antenna and radar operation; and algorithms used to process the radar images. This book brings together material from these different areas to allow readers to gain a thorough understanding of how radar images are processed.The book is divided into three main parts and covers:* DSP principles and signal characteristics in both analog and digital domains, advanced signal sampling, and

  18. Applications Of Image Processing In Criminalistics

    Science.gov (United States)

    Krile, Thomas F.; Walkup, John F.; Barsallo, Adonis; Olimb, Hal; Tarng, Jaw-Horng

    1987-01-01

    A review of some basic image processing techniques for enhancement and restoration of images is given. Both digital and optical approaches are discussed. Fingerprint images are used as examples to illustrate the various processing techniques and their potential applications in criminalistics.

  19. Novel variant (bla(VIM-4)) of the metallo-beta-lactamase gene bla(VIM-1) in a clinical strain of Pseudomonas aeruginosa.

    Science.gov (United States)

    Pournaras, Spyros; Tsakris, Athanassios; Maniati, Maria; Tzouvelekis, Leonidas S; Maniatis, Antonios N

    2002-12-01

    A Pseudomonas aeruginosa isolate highly resistant to carbapenems was collected from a patient with postsurgical cerebrospinal infection in Greece. The isolate carried a class 1 integron that contained as a sole cassette the gene bla(VIM-4), a novel variant of bla(VIM-1), with one nucleotide difference resulting in a Ser-to-Arg change at amino acid position 175 of the VIM-1 enzyme. This is the first detection of a VIM-1 variant after its appearance in Italy. PMID:12435718

  20. Chemometrics applications in biotech processes: a review.

    Science.gov (United States)

    Rathore, Anurag S; Bhushan, Nitish; Hadpe, Sandip

    2011-01-01

    Biotech unit operations are often characterized by a large number of inputs (operational parameters) and outputs (performance parameters) along with complex correlations amongst them. A typical biotech process starts with the vial of the cell bank, ends with the final product, and has anywhere from 15 to 30 such unit operations in series. The aforementioned parameters can impact process performance and product quality and also interact amongst each other. Chemometrics presents one effective approach to gather process understanding from such complex data sets. The increasing use of chemometrics is fuelled by the gradual acceptance of quality by design and process analytical technology amongst the regulators and the biotech industry, which require enhanced process and product understanding. In this article, we review the topic of chemometrics applications in biotech processes with a special focus on recent major developments. Case studies have been used to highlight some of the significant applications.

  1. Applications of random process excursion analysis

    CERN Document Server

    Brainina, Irina S

    2013-01-01

    This book addresses one of the key problems in signal processing, the problem of identifying statistical properties of excursions in a random process in order to simplify the theoretical analysis and make it suitable for engineering applications. Precise and approximate formulas are explained, which are relatively simple and can be used for engineering applications such as the design of devices which can overcome the high initial uncertainty of the self-training period. The information presented in the monograph can be used to implement adaptive signal processing devices capable of d

  2. Applications of Parallel Processing in Mobile Banking

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available The future of mobile banking will be represented by such applications that support mobile, Internet banking and EFT (Electronic Funds Transfer transactions in a single user interface. In such a way, the mobile banking will be able to cover all the types of applications demanded at the market level. The parallel processing of credit card bank transactions could be performed with the help of a grid network. Excluding some limitations, the grid processing offers huge opportunities to exploit the parallelism. For this reason, a lot of applications of waiting queues in grid processing were developed in the last years. Grid networks represent a distinctive and very modern field of the parallel and distributed processing.

  3. Application of High Pressure in Food Processing

    Directory of Open Access Journals (Sweden)

    Herceg, Z.

    2011-01-01

    Full Text Available In high pressure processing, foods are subjected to pressures generally in the range of 100 – 800 (1200 MPa. The processing temperature during pressure treatments can be adjusted from below 0 °C to above 100 °C, with exposure times ranging from a few seconds to 20 minutes and even longer, depending on process conditions. The effects of high pressure are system volume reduction and acceleration of reactions that lead to volume reduction. The main areas of interest regarding high-pressure processing of food include: inactivation of microorganisms, modification of biopolymers, quality retention (especially in terms of flavour and colour, and changes in product functionality. Food components responsible for the nutritive value and sensory properties of food remain unaffected by high pressure. Based on the theoretical background of high-pressure processing and taking into account its advantages and limitations, this paper aims to show its possible application in food processing. The paper gives an outline of the special equipment used in highpressure processing. Typical high pressure equipment in which pressure can be generated either by direct or indirect compression are presented together with three major types of high pressure food processing: the conventional (batch system, semicontinuous and continuous systems. In addition to looking at this technology’s ability to inactivate microorganisms at room temperature, which makes it the ultimate alternative to thermal treatments, this paper also explores its application in dairy, meat, fruit and vegetable processing. Here presented are the effects of high-pressure treatment in milk and dairy processing on the inactivation of microorganisms and the modification of milk protein, which has a major impact on rennet coagulation and curd formation properties of treated milk. The possible application of this treatment in controlling cheese manufacture, ripening and safety is discussed. The opportunities

  4. [Application and obstacles of ANAMMOX process].

    Science.gov (United States)

    Jin Rencun; Zhang, Zhengzhe; Ji, Yuxin; Chen, Hui; Guo, Qiong; Zhou, Yuhuang; Wu, Conghui; Jin, Rencun

    2014-12-01

    Anaerobic ammonium oxidation (ANAMMOX), as its essential advantages of high efficiency and low cost, is a promising novel biological nitrogen elimination process with attractive application prospects. Over the past two decades, many processes based on the ANAMMOX reaction have been continuously studied and applied to practical engineering, with the perspective of reaching 100 full-scale installations in operation worldwide by 2014. Our review summarizes various forms of ANAMMOX processes, including partial nitritation-ANAMMOX, completely autotrophic nitrogen removal over nitrite, oxygen limited autotrophic nitrification and denitrification, denitrifying ammonium oxidation, aerobic deammonification, simultaneous partial nitrification, ANAMMOX and denitrification, single-stage nitrogen removal using ANAMMOX and partial nitritation. We also compare the operating conditions for one-stage and two-stage processes and summarize the obstacles and countermeasures in engineering application of ANAMMOX systems, such as moving bed biofilm reactor, sequencing batch reactor and granular sludge reactor. Finally, we discuss the future research and application direction, which should focus on the optimization of operating conditions and applicability of the process to the actual wastewater, especially on automated control and the impact of special wastewater composition on process performance. PMID:26016370

  5. Image Processing Application on Graphics processors

    Directory of Open Access Journals (Sweden)

    Chouchene Marwa

    2014-04-01

    Full Text Available In this work, we introduce real time image processing techniques using modern programmable Graphic Processing Units GPU. GPU are SIMD (Single Instruction, Multiple Data device that is inherently data-parallel. By utilizing NVIDIA new GPU programming framework, “Compute Unified Device Architecture” CUDA as a computational resource, we realize significant acceleration in image processing algorithm computations. We show that a range of computer vision algorithms map readily to CUDA with significant performance gains. Specifically, we demonstrate the efficiency of our approach by a parallelization and optimization of image processing, Morphology applications and image integral.

  6. Multilocus Sequence Types of Carbapenem-Resistant Pseudomonas aeruginosa in Singapore Carrying Metallo-β-Lactamase Genes, Including the Novel blaIMP-26 Gene▿

    OpenAIRE

    Koh, Tse Hsien; Khoo, Cheng Teng; Tan, Thuan Tong; Mohamed Arshad, Mohamed Amir Bin; Ang, Li Ping; Lau, Lee Jin; Hsu, Li-Yang; Ooi, Eng Eong

    2010-01-01

    Nine imipenem-resistant Pseudomonas aeruginosa isolates were found to contain a variety of metallo-β-lactamase genes, including blaIMP-1, blaIMP-7, blaVIM-2, blaVIM-6, and the novel blaIMP-26. Multilocus sequence typing showed a diversity of sequence types. Comparison with isolates from an earlier study showed that the epidemic clones from 2000 have not become established.

  7. DATA AND PROCESSING IN DEVELOPING ECCONOMIC APPLICATIONS

    Directory of Open Access Journals (Sweden)

    ADRIAN GHENCEA

    2011-04-01

    Full Text Available Economic Informatics originates in the industry economy and the electronic processing of information. A clear distinction is made between IT and economic informatics, and further between general and particular economic informatics (the particular economic informatics meaning administration, industrial informatics etc. Economic informatics is deemed to be an applicative science relating to the conception, working modality and representation of IT and communication systems, oriented towards companies which are using electronic computers. This paper pursues to integrate applications allowing the information systems to interconnect at informational level, by information sharing, and at service level, considering the control of the related processes in real time.

  8. Potential for nuclear process heat application

    International Nuclear Information System (INIS)

    Since more than five decades, nuclear power is being used for commercial electricity generation. There is, however, also a large potential in the non-electric market, where nuclear energy has currently only little penetration. Many industrial sectors have a high demand for process heat and steam at various levels of temperature and pressure to be provided for different industrial processes. All Gen-IV concepts proposed are designed for coolant temperatures above 500 deg. C, which principally allow applications in the low and medium temperature range. Most industries need to rely on a secure and economic supply with energy to guarantee continuous and reliable operation of their process units. A modular arrangement of several units will be necessary for redundancy, reliability and reserve capacity reasons which again reduce power size per modular unit. For nuclear process heat plants in close vicinity to the site of application, conceivable event scenarios characterized by interacting influences must be taken into account. The main challenge at present is to include nuclear CHP applications into the general strategies. In the low temperature heat market, typical examples of nuclear applications are district heating or seawater desalination, both with some experience, but still lacking the large-scale demonstration. In the area of high temperature heat demand, the chemical and petrochemical industries offer ideal chances of CHP market penetration by nuclear power with near-term prospects. (author)

  9. Temporal information processing technology and its applications

    CERN Document Server

    Tang, Yong; Tang, Na

    2011-01-01

    Presenting a systematic introduction to temporal model and time calculation, this volume explores temporal information processing technology and its applications. Topics include the time model in terms of calculus and logic, temporal data models and database concepts, temporal query language, and more.

  10. 7 CFR 1780.39 - Application processing.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE (CONTINUED) WATER AND WASTE LOANS AND GRANTS Loan and Grant Application Processing § 1780.39... providing the services necessary to plan projects including design of facilities, environmental review and... of professional services required and at a fair and reasonable price. (ii) When project...

  11. Image Processing and its Military Applications

    Directory of Open Access Journals (Sweden)

    V. V.D. Shah

    1987-10-01

    Full Text Available One of the important breakthroughs, image processing is the stand alone, non-human image understanding system (IUS. The task of understanding images becomes monumental as one tries to define what understanding really is. Both pattern recognition and artificial intelligence are used in addition to traditional signal processing. Scene analysis procedures using edge and texture segmentation can be considered as the early stages of image understanding process. Symbolic representation and relationship grammers come at subsequent stages. Thus it is not reasonable to put a man into a loop of signal processing at certain sensors such as remotely piloted vehicles, satellites and spacecrafts. Consequently smart sensors and semi-automatic processes are being developed. Land remote sensing has been another important application of the image processing. With the introduction of programmes like Star Wars this particular application has gained a special importance from the Military's point of view. This paper provides an overview of digital image processing and explores the scope of the technology of remote sensing and IUSs from the Military's point of view. An example of the autonomous vehicle project now under progress in the US is described in detail to elucidate the impact of IUSs.

  12. Electron accelerator applications for radiation processing

    International Nuclear Information System (INIS)

    Full text: Department of Nuclear Sciences and Applications (NS) - contributes to the worldwide nuclear sciences and technology development. Through NS, jointly with institutes and laboratories worldwide, the IAEA supports R and D on critical problems facing developing countries. Work targets food, health, water, environment and high tech areas where nuclear and radiation technologies can make a difference. The results and recommendations from the programme elaborated at NAPC lead to organization and execution of the following meetings on the most important issues regarding radiation technology applications, mostly based on accelerator technology: - Technical Meeting (TM) on 'Emerging Applications of Radiation Processing', April, 2003, Vienna, Austria (TECDOC-1386) - Consultants Meeting (CT) on 'Advances in Radiation Processing of Polymers', September 2003, Notre Dame, Indiana, U.S.A. (TECDOC-1420) - Consultants Meeting (CT) on 'Status of Industrial Scale Radiation Treatment of Wastewater', October 2003, Daejon, Republic of Korea (TECDOC-1407) - Consultants Meeting (CT) on 'Radiation Processing of Polysaccharides', November 2003, Takasaki, Japan (TECDOC-1422) - Consultants Meeting (CT) on 'Emerging Applications of Radiation in Nanotechnology', March 2004, Bologna, Italy (TECDOC-1438) - Consultants Meeting (CT) on 'Radiation Processing of Gaseous and Liquid Effluents', September 2004, Sofia, Bulgaria. The total number of accelerators installed all over the world exceeds 13,000, among them the number of units applied for radiation processing being close to 1,200. Direct, transformer accelerators, single resonant cavity accelerators and microwave source powered linear accelerators have been found to be the most suitable for radiation processing. The industrial accelerators' development is still in progress, not only due to new areas of application but also because of demands of lower cost and more compact size machines. Some new countries elaborated their own

  13. Incidence of blaNDM-1 gene in Escherichia coli isolates at a tertiary care referral hospital in Northeast India

    Directory of Open Access Journals (Sweden)

    A Bora

    2013-01-01

    Full Text Available Purpose: Increasing reports on New Delhi metallo-β-lactamase-1 (NDM-1 producing Escherichia coli constitute a serious threat to global health since it is found to be highly resistant to most of the currently available antibiotics including carbapenems. This study has been performed to find out the incidence blaNDM-1 in E. coli isolates recovered from the various clinical samples at a tertiary care referral hospital in Northeast India. Materials and Methods: A total of 270 non-duplicated E. coli isolates were recovered from the various clinical samples at a tertiary care referral hospital in Northeast India. All isolates with reduced susceptibility to meropenem or ertapenem (diameter of zones of inhibition, ≤21 mm were further phenotypically confirmed for carbapenemase production by modified Hodge test. All screened isolates were also subjected to the polymerase chain reaction detection of blaNDM-1 gene and additional bla genes coding for transmission electron microscopy, SHV, CTX-M, and AmpC. Results: Out of 270 E. coli isolates, 14 were screened for carbapenemase production on the basis of their reduced susceptibility to meropenem or ertapenem. All screened isolates were found to be positive for blaNDM-1 . Each of the blaNDM-1 possessing isolate was also positive for two or more additional bla genes, such as blaTEM , blaCTX-M and blaAmpC . Phylogenetic analysis showed very less variation in blaNDM-1 gene with respect to blaNDM-1 possessing E. coli isolates from other parts of India and abroad. Conclusions: Our findings highlight the incidence of blaNDM-1 in E. coli isolates with a reduced susceptibility to meropenem or ertapenem.

  14. How to identify Raoultella spp. including R. ornithinolytica isolates negative for ornithine decarboxylase? The reliability of the chromosomal bla gene.

    Science.gov (United States)

    Walckenaer, Estelle; Leflon-Guibout, Véronique; Nicolas-Chanoine, Marie-Hélène

    2008-12-01

    Although Raoultella planticola and Raoultella ornithinolytica were described more than 20 years ago, identifying them remains difficult. The reliability of the chromosomal bla gene for this identification was evaluated in comparison with that of the 16S rDNA and rpoB genes in 35 Raoultella strains from different origins. Of the 26 strains previously identified as R. planticola by biochemical tests alone or in association with molecular methods, 21 harboured a bla gene with 99.8% identity with the bla gene of two reference R. ornithinolytica strains (bla(ORN) gene) and 5 harboured a bla gene with 99.2% identity with the bla gene of two reference R. planticola strains (bla(PLA) gene). The 9 isolates previously identified as R. ornithinolytica harboured a bla(ORN) gene. The bla gene-based identification was confirmed by 16S rDNA and rpoB sequencing. The 21 isolates newly identified as R. ornithinolytica had a test negative for ornithine decarboxylase (ODC). Molecular experiments suggested one copy of ODC-encoding gene in both ODC-negative R. ornithinolytica and R. planticola strains and two copies in ODC-positive R. orninthinolytica strains. Analysis of the 35 bla genes allowed us (i) to confirm an identity of only 94% between the bla genes of the two Raoultella species while this identity was > 98% for rpoB and > 99% for 16S rDNA genes and (ii) to develop and successfully apply a bla PCR RFLP assay for Raoultella spp. identification. Overall, this study allowed us to discover ODC-negative R. ornithinolytica and to provide a reliable Raoultella identification method widely available as not requiring sequencing equipment.

  15. Identification of Acinetobacter baumannii by detection of the blaOXA-51-like carbapenemase gene intrinsic to this species.

    Science.gov (United States)

    Turton, Jane F; Woodford, Neil; Glover, Judith; Yarde, Susannah; Kaufmann, Mary E; Pitt, Tyrone L

    2006-08-01

    bla(OXA-51-like) was sought in clinical isolates of Acinetobacter species in a multiplex PCR, which also detects bla(OXA-23-like) and class 1 integrase genes. All isolates that gave a band for bla(OXA-51-like) identified as A. baumannii. This gene was detected in each of 141 isolates of A. baumannii but not in those of 22 other Acinetobacter species.

  16. Characterization of the genetic environment of the blaKPC-2 gene among Klebsiella pneumoniae isolates from a Chinese Hospital.

    Science.gov (United States)

    Shen, Pinghua; Zhang, Ying; Li, Gang; Jiang, Xiaofei

    2016-01-01

    Infection caused by carbapenem-resistant Klebsiella pneumoniae has become a major healthcare threat and KPC-2 enzyme is a dominant factor mediating carbapenems resistance in K. pneumoniae. This study was designed to determine the genetic environment of blaKPC-2, which prevailed in clinical K. pneumoniae isolates recovered in Huashan Hospital, Shanghai, China. Forty-two clinical isolates were included in this study by blaKPC-2 screening. After multilocus sequence typing and plasmid analyses of PCR-based replicon typing (PBRT), junction PCR, mapping PCR and crossing PCR assays, primer walking, and amplicon sequencing were used to analyze the genetic environment of the blaKPC-2 gene. ST423, ST65, ST977, and ST11 were all detected in KPC-2-producing K. pneumoniae. Two types of blaKPC-2-bearing genetic structure were found: Tn1721-blaKPC-2-Tn3 and Tn1721-blaKPC-2-ΔTn3-IS26; and were carried in IncX and IncFII plasmids, respectively. In conclusion, the genetic environment of the blaKPC-2 gene was diverse and Tn1721-blaKPC-2-ΔTn3-IS26 was dominant in clinical K. pneumoniae isolates in Huashan Hospital. This study sheds some light on the genetic environment and should foster further studies about the mechanism of the blaKPC-2 dissemination.

  17. Computer performance optimization systems, applications, processes

    CERN Document Server

    Osterhage, Wolfgang W

    2013-01-01

    Computing power performance was important at times when hardware was still expensive, because hardware had to be put to the best use. Later on this criterion was no longer critical, since hardware had become inexpensive. Meanwhile, however, people have realized that performance again plays a significant role, because of the major drain on system resources involved in developing complex applications. This book distinguishes between three levels of performance optimization: the system level, application level and business processes level. On each, optimizations can be achieved and cost-cutting p

  18. Finite Markov processes and their applications

    CERN Document Server

    Iosifescu, Marius

    2007-01-01

    A self-contained treatment of finite Markov chains and processes, this text covers both theory and applications. Author Marius Iosifescu, vice president of the Romanian Academy and director of its Center for Mathematical Statistics, begins with a review of relevant aspects of probability theory and linear algebra. Experienced readers may start with the second chapter, a treatment of fundamental concepts of homogeneous finite Markov chain theory that offers examples of applicable models.The text advances to studies of two basic types of homogeneous finite Markov chains: absorbing and ergodic ch

  19. Stream Processing Environmental Applications in Jordan Valley

    Directory of Open Access Journals (Sweden)

    Iyad Ahmad Aldasouqi, Jalal Atoum

    2011-04-01

    Full Text Available Database system architectures have been gone through innovative changes, specially theunifications of algorithms and data via the integration of programming languages with thedatabase system. Such an innovative changes is needed in Stream-based applications since theyhave different requirements for the principal of stream data processing system. For example, themonitoring component requires query processing system to detect user-defined events in a timelymanner as in real time monitoring system. Furthermore, stream processing fits a large class ofnew applications for which conventional DBMSs fall short since many stream-oriented systemsare inherently geographically distributed and the distribution offers a scalable load managementand higher availability.This paper presents statistical information about metrological data such as the weather, soil andevapotranspiration as collected by the weather stations distributed in different locations in JordanValley. In addition, it shows the importance of Stream Processing in some real life applications,and shows how the database systems can help researcher in building prototypes that can beimplemented and used in a continuous monitoring system.

  20. Atmospheric plasma processes for environmental applications

    OpenAIRE

    Shapoval, Volodymyr

    2012-01-01

    Plasma chemistry is a rapidly growing field which covers applications ranging from technological processing of materials, including biological tissues, to environmental remediation and energy production. The so called atmospheric plasma, produced by electric corona or dielectric barrier discharges in a gas at atmospheric pressure, is particularly attractive for the low costs and ease of operation and maintenance involved. The high concentrations of energetic and chemically active species (e.g...

  1. Pseudo random signal processing theory and application

    CERN Document Server

    Zepernick, Hans-Jurgen

    2013-01-01

    In recent years, pseudo random signal processing has proven to be a critical enabler of modern communication, information, security and measurement systems. The signal's pseudo random, noise-like properties make it vitally important as a tool for protecting against interference, alleviating multipath propagation and allowing the potential of sharing bandwidth with other users. Taking a practical approach to the topic, this text provides a comprehensive and systematic guide to understanding and using pseudo random signals. Covering theoretical principles, design methodologies and applications

  2. Goslar Blaž Demšar: prispevek za zgodovino slovenskega glasbilarstva:

    OpenAIRE

    Pokorn, Danilo

    1999-01-01

    The article is didiceted to Blaž Demšar (1903-1981), the best Slovene violin maker. He was the first in Slovenia who elevated violin making to the level of artistry and also archieved international recognition with his instruments Prispevek je posvečen Blažu Demšarju (1903-1981), najboljšemu slovenskemu goslarju. Goslarstvo je kot prvi na Slovenskem povzdignil na reven umetniškega oblikovanja in s svojimi instrumenti dosegel priznanje tudi v tujini

  3. Non-O1/Non-O139 Vibrio cholerae Avian Isolate from France Cocarrying the bla(VIM-1) and bla(VIM-4) Genes.

    Science.gov (United States)

    Aberkane, Salim; Compain, Fabrice; Barraud, Olivier; Ouédraogo, Abdoul-Salam; Bouzinbi, Nicolas; Vittecoq, Marion; Jean-Pierre, Hélène; Decré, Dominique; Godreuil, Sylvain

    2015-10-01

    We describe here a non-O1/non-O139 Vibrio cholerae isolate producing both VIM-1 and VIM-4 carbapenemases. It was isolated from a yellow-legged gull in southern France. The blaVIM genes were part of a class 1 integron structure located in an IncA/C plasmid. This study emphasizes the presence of carbapenemase genes in wildlife microbiota.

  4. Parallelism and Scalability in an Image Processing Application

    DEFF Research Database (Denmark)

    Rasmussen, Morten Sleth; Stuart, Matthias Bo; Karlsson, Sven

    2008-01-01

    parallel programs. This paper investigates parallelism and scalability of an embedded image processing application. The major challenges faced when parallelizing the application were to extract enough parallelism from the application and to reduce load imbalance. The application has limited immediately...

  5. Soft Computing Techniques for Process Control Applications

    Directory of Open Access Journals (Sweden)

    Rahul Malhotra

    2011-09-01

    Full Text Available Technological innovations in soft computing techniques have brought automation capabilities to new levelsof applications. Process control is an important application of any industry for controlling the complexsystem parameters, which can greatly benefit from such advancements. Conventional control theory isbased on mathematical models that describe the dynamic behaviour of process control systems. Due to lackin comprehensibility, conventional controllers are often inferior to the intelligent controllers. Softcomputing techniques provide an ability to make decisions and learning from the reliable data or expert’sexperience. Moreover, soft computing techniques can cope up with a variety of environmental and stabilityrelated uncertainties. This paper explores the different areas of soft computing techniques viz. Fuzzy logic,genetic algorithms and hybridization of two and abridged the results of different process control casestudies. It is inferred from the results that the soft computing controllers provide better control on errorsthan conventional controllers. Further, hybrid fuzzy genetic algorithm controllers have successfullyoptimized the errors than standalone soft computing and conventional techniques.

  6. Availability of underlayer application to EUV process

    Science.gov (United States)

    Kosugi, Hitoshi; Fonseca, Carlos; Iwao, Fumiko; Marumoto, Hiroshi; Kim, Hyun-Woo; Cho, Kyoungyong; Park, Cheol-Hong; Park, Chang-Min; Na, Hai-Sub; Koh, Cha-Won; Cho, Hanku

    2011-04-01

    EUV lithography is one of the most promising technologies for the fabrication of beyond 30nm HP generation devices. However, it is well-known that EUV lithography still has significant challenges. A great concern is the change of resist material for EUV resist process. EUV resist material formulations will likely change from conventional-type materials. As a result, substrate dependency needs to be understood. TEL has reported that the simulation combined with experiments is a good way to confirm the substrate dependency. In this work the application of HMDS treatment and SiON introduction, as an underlayer, are studied to cause a footing of resist profile. Then, we applied this simulation technique to Samsung EUV process. We will report the benefit of this simulation work and effect of underlayer application. Regarding the etching process, underlayer film introduction could have significant issues because the film that should be etched off increases. For that purpose, thinner films are better for etching. In general, thinner films may have some coating defects. We will report the coating coverage performance and defectivity of ultra thin film coating.

  7. Modelling and application of stochastic processes

    CERN Document Server

    1986-01-01

    The subject of modelling and application of stochastic processes is too vast to be exhausted in a single volume. In this book, attention is focused on a small subset of this vast subject. The primary emphasis is on realization and approximation of stochastic systems. Recently there has been considerable interest in the stochastic realization problem, and hence, an attempt has been made here to collect in one place some of the more recent approaches and algorithms for solving the stochastic realiza­ tion problem. Various different approaches for realizing linear minimum-phase systems, linear nonminimum-phase systems, and bilinear systems are presented. These approaches range from time-domain methods to spectral-domain methods. An overview of the chapter contents briefly describes these approaches. Also, in most of these chapters special attention is given to the problem of developing numerically ef­ ficient algorithms for obtaining reduced-order (approximate) stochastic realizations. On the application side,...

  8. Complete Genome Sequence of a Klebsiella pneumoniae Strain Carrying blaNDM-1 on a Multidrug Resistance Plasmid

    Science.gov (United States)

    Lau, Anna F.; Palmore, Tara N.; Frank, Karen M.; Segre, Julia A.

    2016-01-01

    Here, we report the genome sequence of a blaNDM-1-positive Klebsiella pneumoniae AATZP isolate cultured from a perirectal surveillance swab collected upon admission of a patient to the NIH Clinical Center in 2014. Genome sequencing of this isolate revealed three plasmids, including one carrying the blaNDM-1 gene encoding resistance to carbapenems. PMID:27417839

  9. Micro Nano Replication Processes and Applications

    CERN Document Server

    Kang, Shinill

    2012-01-01

    This book is an introduction to the fundamentals and processes for micro and nano molding for plastic components. In addition to the basics, the book covers applications details and examples. The book helps both students and professionals to understand and work with the growing tools of molding and uses for micro and nano-sized plastic parts.Provides a comprehensive presentation on fundamentals and practices of manufacturing for micro / nano sized plastics partsCovers a relatively new but fast-growing field that is impacting any industry using plastic parts in their products (electronics, tele

  10. RF applications in digital signal processing

    CERN Document Server

    Schilcher, T

    2008-01-01

    Ever higher demands for stability, accuracy, reproducibility, and monitoring capability are being placed on Low-Level Radio Frequency (LLRF) systems of particle accelerators. Meanwhile, continuing rapid advances in digital signal processing technology are being exploited to meet these demands, thus leading to development of digital LLRF systems. The rst part of this course will begin by focusing on some of the important building-blocks of RF signal processing including mixer theory and down-conversion, I/Q (amplitude and phase) detection, digital down-conversion (DDC) and decimation, concluding with a survey of I/Q modulators. The second part of the course will introduce basic concepts of feedback systems, including examples of digital cavity eld and phase control, followed by radial loop architectures. Adaptive feed-forward systems used for the suppression of repetitive beam disturbances will be examined. Finally, applications and principles of system identi cation approaches will be summarized.

  11. Processes and applications of electrostatic fiber formation

    Energy Technology Data Exchange (ETDEWEB)

    Rutledge, Gregory C [Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States)], E-mail: rutledge@mit.edu

    2008-12-01

    'Electrospinning' is an electrohydrodynamic jetting process that enables the production of continuous fibers, tubes and wires with diameters as small as 10 nm. The process itself is dependent upon electrostatic interactions such as charge-charge repulsion and charge-field interaction. The interplay of charge repulsion, viscoelasticity and surface tension gives rise to interesting electrohydrodynamic phenomena that challenge fundamental understanding as well as practical implementation and quality control in the final fibers. The morphology and diameter of these fibers can be understood and controlled through manipulation of fluid properties and operating parameters. The fibers thus produced are illustrative of nanotechnology in a 1-dimensional form, and have inspired considerable activity in the research community into their potential applications. Proposed uses range from high performance filtration media and membranes, to sensors and actuators, to medical devices and drug delivery vehicles. Two examples, tissue scaffold engineering and superhydrophobicity, are illustrated here.

  12. Genetic Structure Associated with blaOXA-18, Encoding a Clavulanic Acid-Inhibited Extended-Spectrum Oxacillinase▿

    Science.gov (United States)

    Naas, Thierry; Namdari, Fatemeh; Bogaerts, Pierre; Huang, Te-Din; Glupczynski, Youri; Nordmann, Patrice

    2008-01-01

    The genetic environment of the blaOXA-18 gene encoding a peculiar clavulanic acid-inhibitable Ambler class D extended-spectrum β-lactamase was determined from the prototype OXA-18-producing Pseudomonas aeruginosa MUS clinical isolate. An 8.2-kb genomic DNA fragment containing blaOXA-18 was cloned from P. aeruginosa MUS. Although most oxacillinases are located in integrons, blaOXA-18 lacked gene cassette-specific features. It was bracketed by two duplicated sequences containing ISCR19, a novel insertion sequence of the ISCR family of mobile elements; ΔintI1, a truncated integrase gene; and a truncated Δaac6′-Ib gene cassette. It is likely that ISCR19 was at the origin of the blaOXA-18 gene mobilization by a rolling-circle transposition event followed by homologous recombination. Furthermore, analysis of the cloned genomic DNA fragment revealed the presence of the integron-containing blaOXA-20 gene. Concomitantly, three P. aeruginosa clinical isolates, displaying a synergy image as determined by double-disk diffusion tests on cloxacillin-containing plates, were isolated from three patients hospitalized in different wards over a 9-month period at the Saint-Luc University hospital (Brussels, Belgium). These isolates were positive by PCR for blaOXA-18 and blaOXA-20 genes, genetically related to P. aeruginosa MUS as determined by pulsed-field gel electrophoresis, and carried the same blaOXA-18/blaOXA-20-associated genetic structures. This report characterized the genetic elements likely at the origin of blaOXA-18 gene mobilization in P. aeruginosa and suggests the spread of oxacillin-type extended-spectrum β-lactamases in P. aeruginosa at the Saint-Luc University hospital of Brussels, Belgium. PMID:18663027

  13. Identification of bla KPC-2 on different plasmids of three Morganella morganii isolates.

    Science.gov (United States)

    Shi, D-S; Wang, W-P; Kuai, S-G; Shao, H-F; Huang, M

    2012-05-01

    Three Morganella morganii strains resistant to carbapenems were recovered from the surgical intensive care unit (SICU) in our hospital. Carbapenemases and extended-spectrum β-lactamases (ESBLs) were respectively detected by the modified Hodge test and the modified Clinical and Laboratory Standards Institute (CLSI) ESBL confirmatory test in all isolates. Amplification of whole-cell and plasmid DNAs extracted from isolates with primers specific for the bla (KPC) produced an amplicon confirmed to be bla (KPC-2) by sequence analysis. Pulsed-field gel electrophoresis (PFGE) typing revealed that three isolates belonged to two closely related types. Plasmids electrophoresis and restriction analysis revealed that the bla (KPC-2) was located on different plasmids. The transfer of carbapenem resistance from the three original isolates to Escherichia coli EC600 was successful by conjugation. An examination of the outer membrane proteins showed a lack of a 38-kDa outer membrane protein (OMP) compared with M. morganii susceptible to carbapenems. The production of KPC-2 and ESBLs, combined with OMP deficiency, resulted in high-level carbapenem resistance in the M. morganii strains. The genetic environment around bla (KPC-2) analysis revealed that this β-lactamase was located on the same mobile genetic elements which could transfer between different plasmids.

  14. First report of the blaVIM gene in environmental isolates of Buttiauxella sp.

    Science.gov (United States)

    Pitondo-Silva, André; Martins, Vinicius Vicente; Stehling, Eliana Guedes

    2015-04-01

    Several works have demonstrated the presence of metallo-β-lactamases (MBLs) in clinical bacteria. However, in environmental isolates, few works have reported on these enzymes. In this study, we report for the first time two environmental isolates of Buttiauxella sp. recovered from chrysanthemum plantations in Brazil containing blaVIM gene and producing MBLs.

  15. Materials, Applications and Processes in Photocatalysis

    Energy Technology Data Exchange (ETDEWEB)

    Keller, N.; Robert, D.; Herrmann, J.M.; Keller, V. (eds.)

    2007-04-15

    Catalysis Today publishes special issues only. The Journal focuses on the rapid publication of invited papers devoted to currently important topics in catalysis and related subjects. Both fundamental and applied aspects of catalysis are covered. While many of the issues are concerned with heterogeneous catalysis, subjects such as homogeneous catalysis and enzymatic catalysis may also be included. Subjects related to catalysis such as techniques, adsorption, process technology and others are included if there is a clear relationship with catalysis. This special issue concerns 21 papers on Materials, Applications and Processes in Photocatalysis: (1) Photoactive titania nanostructured thin films: Synthesis and characteristics of ordered helical nanocoil array; (2) The design of highly active rectangular column-structured titanium oxide photocatalysts and their application in purification systems; (3) Photosensitization of TiO{sub 2} by M{sub x}O{sub y} and M{sub x}S{sub y} nanoparticles for heterogeneous photocatalysis applications; (4) Oxidation of nauseous sulfur compounds by photocatalysis or photosensitization; (5) In situ characterization of the highly dispersed Mo{sup 6+}-oxide species supported onto various oxides and their photocatalytic reactivities; (6) The photocatalytic reforming of methanol; (7) Photocatalysis for new energy production: Recent advances in photocatalytic water splitting reactions for hydrogen production; (8) Visible light induced hydrogen evolution over the heterosystem Bi{sub 2}S{sub 3}/TiO{sub 2}; (9) Modeling and optimizing irradiance on planar, folded, and honeycomb shapes to maximize photocatalytic air purification; (10) Dimensionless analysis of slurry photocatalytic reactors using two-flux and six-flux radiation absorption-scattering models; (11) Photoreactions occurring on metal-oxide surfaces are not all photocatalytic: Description of criteria and conditions for processes to be photocatalytic; (12) Temperature dependent

  16. Applications of power ultrasound in food processing.

    Science.gov (United States)

    Kentish, Sandra; Feng, Hao

    2014-01-01

    Acoustic energy as a form of physical energy has drawn the interests of both industry and scientific communities for its potential use as a food processing and preservation tool. Currently, most such applications deal with ultrasonic waves with relatively high intensities and acoustic power densities and are performed mostly in liquids. In this review, we briefly discuss the fundamentals of power ultrasound. We then summarize the physical and chemical effects of power ultrasound treatments based on the actions of acoustic cavitation and by looking into several ultrasound-assisted unit operations. Finally, we examine the biological effects of ultrasonication by focusing on its interactions with the miniature biological systems present in foods, i.e., microorganisms and food enzymes, as well as with selected macrobiological components. PMID:24422590

  17. Application of Glass Transition in Food Processing.

    Science.gov (United States)

    Balasubramanian, S; Devi, Apramita; Singh, K K; Bosco, S J D; Mohite, Ashish M

    2016-01-01

    The phenomenon of glass transition has been employed to food products to study their stability. It can be applied as an integrated approach along with water activity and physical and chemical changes in food in processing and storage to determine the food stability. Also associated with the changes during agglomeration crystallization, caking, sticking, collapse, oxidation reactions, nonenzymatic browning, and microbial stability of food system. Various techniques such as Differential Scanning Calorimetry, Nuclear Magnetic Resonance, etc. have been developed to determine the glass transition temperature (Tg) of food system. Also, various theories have been applied to explain the concept of Tg and its relation to changes in food system. This review summarizes the understanding of concept of glass transition, its measurement, and application in food technology.

  18. A generalized Cauchy process and its application to relaxation phenomena

    Energy Technology Data Exchange (ETDEWEB)

    Lim, S C [Faculty of Engineering, Multimedia University, 63100 Cyberjaya, Selangor (Malaysia); Li Ming [School of Information Science and Technology, East China Normal University, Shanghai 200026 (China)

    2006-03-24

    We study some of the basic properties of a generalized Cauchy process indexed by two parameters. The application of the Lamperti transformation to the generalized Cauchy process leads to a self-similar process which preserves the long-range dependence. The asymptotic properties of spectral density of the process are derived. Possible application of this process to model relaxation phenomena is considered.

  19. Biogas reforming process investigation for SOFC application

    International Nuclear Information System (INIS)

    Highlights: • Mathematical model of fuel processor and experimental validation was made. • Simulations made to find syngas composition varying fuel processor operating conditions. • Experimental tests were carried out on SOFC mono-cell to obtain polarization curves. • The best conditions for SOFC/fuel processor integrated systems were defined. - Abstract: In recent years, research efforts on fuel cells have been addressed on the development of multifuel reformers with particular emphasis toward the potential use of non-traditional fuels. Among these, biogas is considered very promising to be used as syngas source for fuel cell system applications. The interest on this hydrogen source is focused mainly to supply high temperature fuel cells (HTFC). This paper reports a wide experimental research investigation on SOFC device supplied by syngas produced with different biogas reforming processes (steam reforming, autothermal reforming and partial oxidation). Thermodynamic simulations have been performed to determine the reformed gas composition varying process, reaction temperature and steam to carbon – oxygen to carbon ratios. Syngas mixtures obtained were experimentally tested in order to evaluate the performance of a SOFC mono-cell. Furthermore, an analysis of the combination: fuel processor with a SOFC stack has been determined in order to assess the total energy efficiency

  20. Decision analysis applications and the CERCLA process

    Energy Technology Data Exchange (ETDEWEB)

    Purucker, S.T.; Lyon, B.F. [Oak Ridge National Lab., TN (United States). Risk Analysis Section]|[Univ. of Tennessee, Knoxville, TN (United States)

    1994-06-01

    Quantitative decision methods can be developed during environmental restoration projects that incorporate stakeholder input and can complement current efforts that are undertaken for data collection and alternatives evaluation during the CERCLA process. These decision-making tools can supplement current EPA guidance as well as focus on problems that arise as attempts are made to make informed decisions regarding remedial alternative selection. In examining the use of such applications, the authors discuss the use of decision analysis tools and their impact on collecting data and making environmental decisions from a risk-based perspective. They will look at the construction of objective functions for quantifying different risk-based perspective. They will look at the construction of objective functions for quantifying different risk-based decision rules that incorporate stakeholder concerns. This represents a quantitative method for implementing the Data Quality Objective (DQO) process. These objective functions can be expressed using a variety of indices to analyze problems that currently arise in the environmental field. Examples include cost, magnitude of risk, efficiency, and probability of success or failure. Based on such defined objective functions, a project can evaluate the impact of different risk and decision selection strategies on data worth and alternative selection.

  1. Multivariate Statistical Process Control Process Monitoring Methods and Applications

    CERN Document Server

    Ge, Zhiqiang

    2013-01-01

      Given their key position in the process control industry, process monitoring techniques have been extensively investigated by industrial practitioners and academic control researchers. Multivariate statistical process control (MSPC) is one of the most popular data-based methods for process monitoring and is widely used in various industrial areas. Effective routines for process monitoring can help operators run industrial processes efficiently at the same time as maintaining high product quality. Multivariate Statistical Process Control reviews the developments and improvements that have been made to MSPC over the last decade, and goes on to propose a series of new MSPC-based approaches for complex process monitoring. These new methods are demonstrated in several case studies from the chemical, biological, and semiconductor industrial areas.   Control and process engineers, and academic researchers in the process monitoring, process control and fault detection and isolation (FDI) disciplines will be inter...

  2. Software engineering processes principles and applications

    CERN Document Server

    Wang, Yingxu

    2000-01-01

    Fundamentals of the Software Engineering ProcessIntroductionA Unified Framework of the Software Engineering ProcessProcess AlgebraProcess-Based Software EngineeringSoftware Engineering Process System ModelingThe CMM ModelThe ISO 9001 ModelThe BOOTSTRAP ModelThe ISO/IEC 15504 (SPICE) ModelThe Software Engineering Process Reference Model: SEPRMSoftware Engineering Process System AnalysisBenchmarking the SEPRM ProcessesComparative Analysis of Current Process ModelsTransformation of Capability Levels Between Current Process ModelsSoftware Engineering Process EstablishmentSoftware Process Establish

  3. Technical review of process heat applications using the HTGR

    International Nuclear Information System (INIS)

    The demand for process heat applications is surveyed. Those applications which can be served only by the high temperature gas-cooled reactor (HTGR) are identified and the status of process heat applications in Europe, USA, and Japan in December 1975 is discussed. Technical problems associated with the HTGR for process heat applications are outlined together with an appraisal of the safety considerations involved. (author)

  4. blaGES carrying Pseudomonas aeruginosa isolates from a public hospital in Rio de Janeiro, Brazil

    Directory of Open Access Journals (Sweden)

    Flávia L. P. C. Pellegrino

    2006-08-01

    Full Text Available Previous analysis of Pseudomonas aeruginosa class-1 integrons from Rio de Janeiro, Brazil, revealed the blaGES gene in one isolate. We screened isolates of two widespread PFGE genotypes, A and B, at a public hospital in Rio, for the presence of blaGES. The gene was detected in all seven P. aeruginosa isolates belonging to genotype B. Three of the seven genotype-B isolates were resistant to amikacin, aztreonam, ceftazidime, cefepime, ciprofloxacin, gentamicin, imipenem, meropenem, piperacillin-tazobactam and ticarcillin-clavulanic acid. The other four isolates were resistant to all these agents, except gentamicin, imipenem, meropenem and piperacillin-tazobactam. A synergistic effect between ceftazidime and imipenem or clavulanic acid suggested the production of GES-type ESBL.

  5. Application of Complex Fluids in Lignocellulose Processing

    Science.gov (United States)

    Carrillo Lugo, Carlos A.

    Complex fluids such as emulsions, microemulsions and foams, have been used for different applications due to the multiplicity of properties they possess. In the present work, such fluids are introduced as effective media for processing lignocellulosic biomass. A demonstration of the generic benefits of complex fluids is presented to enhance biomass impregnation, to facilitate pretreatment for fiber deconstruction and to make compatible cellulose fibrils with hydrophobic polymers during composite manufacture. An improved impregnation of woody biomass was accomplished by application of water-continuous microemulsions. Microemulsions with high water content, > 85%, were formulated and wood samples were impregnated by wicking and capillary flooding at atmospheric pressure and temperature. Formulations were designed to effectively impregnate different wood species during shorter times and to a larger extent compared to the single components of the microemulsions (water, oil or surfactant solutions). The viscosity of the microemulsions and their interactions with cell wall constituents in fibers were critical to define the extent of impregnation and solubilization. The relation between composition and formulation variables and the extent of microemulsion penetration in different woody substrates was studied. Formulation variables such as salinity content of the aqueous phase and type of surfactant were elucidated. Likewise, composition variables such as the water-to-oil ratio and surfactant concentration were investigated. These variables affected the characteristics of the microemulsion and determined their effectiveness in wood treatment. Also, the interactions between the surfactant and the substrate had an important contribution in defining microemulsion penetration in the capillary structure of wood. Microemulsions as an alternative pretreatment for the manufacture of cellulose nanofibrils (CNFs) was also studied. Microemulsions were applied to pretreat lignin

  6. Chemometrics applications in biotech processes: assessing process comparability.

    Science.gov (United States)

    Bhushan, Nitish; Hadpe, Sandip; Rathore, Anurag S

    2012-01-01

    A typical biotech process starts with the vial of the cell bank, ends with the final product and has anywhere from 15 to 30 unit operations in series. The total number of process variables (input and output parameters) and other variables (raw materials) can add up to several hundred variables. As the manufacturing process is widely accepted to have significant impact on the quality of the product, the regulatory agencies require an assessment of process comparability across different phases of manufacturing (Phase I vs. Phase II vs. Phase III vs. Commercial) as well as other key activities during product commercialization (process scale-up, technology transfer, and process improvement). However, assessing comparability for a process with such a large number of variables is nontrivial and often companies resort to qualitative comparisons. In this article, we present a quantitative approach for assessing process comparability via use of chemometrics. To our knowledge this is the first time that such an approach has been published for biotech processing. The approach has been applied to an industrial case study involving evaluation of two processes that are being used for commercial manufacturing of a major biosimilar product. It has been demonstrated that the proposed approach is able to successfully identify the unit operations in the two processes that are operating differently. We expect this approach, which can also be applied toward assessing product comparability, to be of great use to both the regulators and the industry which otherwise struggle to assess comparability.

  7. Application of Java technology in radiation image processing

    International Nuclear Information System (INIS)

    The acquisition and processing of radiation image plays an important role in modern application of civil nuclear technology. The author analyzes the rationale of Java image processing technology which includes Java AWT, Java 2D and JAI. In order to demonstrate applicability of Java technology in field of image processing, examples of application of JAI technology in processing of radiation images of large container have been given

  8. On some applications of diffusion processes for image processing

    Energy Technology Data Exchange (ETDEWEB)

    Morfu, S., E-mail: smorfu@u-bourgogne.f [Laboratoire d' Electronique, Informatique et Image (LE2i), UMR Cnrs 5158, Aile des Sciences de l' Ingenieur, BP 47870, 21078 Dijon Cedex (France)

    2009-06-29

    We propose a new algorithm inspired by the properties of diffusion processes for image filtering. We show that purely nonlinear diffusion processes ruled by Fisher equation allows contrast enhancement and noise filtering, but involves a blurry image. By contrast, anisotropic diffusion, described by Perona and Malik algorithm, allows noise filtering and preserves the edges. We show that combining the properties of anisotropic diffusion with those of nonlinear diffusion provides a better processing tool which enables noise filtering, contrast enhancement and edge preserving.

  9. Rapid thermal processing and beyond applications in semiconductor processing

    CERN Document Server

    Lerch, W

    2008-01-01

    Heat-treatment and thermal annealing are very common processing steps which have been employed during semiconductor manufacturing right from the beginning of integrated circuit technology. In order to minimize undesired diffusion, and other thermal budget-dependent effects, the trend has been to reduce the annealing time sharply by switching from standard furnace batch-processing (involving several hours or even days), to rapid thermal processing involving soaking times of just a few seconds. This transition from thermal equilibrium, to highly non-equilibrium, processing was very challenging a

  10. Radar micro-doppler signatures processing and applications

    CERN Document Server

    Chen, Victor C; Miceli, William J

    2014-01-01

    Radar Micro-Doppler Signatures: Processing and applications concentrates on the processing and application of radar micro-Doppler signatures in real world situations, providing readers with a good working knowledge on a variety of applications of radar micro-Doppler signatures.

  11. Process Fragment Libraries for Easier and Faster Development of Process-based Applications

    Directory of Open Access Journals (Sweden)

    David Schumm

    2011-01-01

    Full Text Available The term “process fragment” is recently gaining momentum in business process management research. We understand a process fragment as a connected and reusable process structure, which has relaxed completeness and consistency criteria compared to executable processes. We claim that process fragments allow for an easier and faster development of process-based applications. As evidence to this claim we present a process fragment concept and show a sample collection of concrete, real-world process fragments. We present advanced application scenarios for using such fragments in development of process-based applications. Process fragments are typically managed in a repository, forming a process fragment library. On top of a process fragment library from previous work, we discuss the potential impact of using process fragment libraries in cross-enterprise collaboration and application integration.

  12. Representation of cointegrated autoregressive processes with application to fractional processes

    DEFF Research Database (Denmark)

    Johansen, Søren

    2009-01-01

    We analyse vector autoregressive processes using the matrix valued characteristic polynomial. The purpose of this  paper is to give a survey of the mathematical results on inversion of a matrix polynomial in case there are unstable roots, to study integrated and cointegrated processes. The new...

  13. Specifying Processes: Application to Electrical Power Distribution

    OpenAIRE

    Sabah Al-Fedaghi; Lina Al-Saleh

    2011-01-01

    Problem statement: This study deals with the problem of how to specify processes. Many process specification methodologies have been determined to be incomplete; for example, ISO 9000:2005 defines process as transforming media inputs into outputs. Nevertheless, the author of the Quality Systems Handbook, declares that such a definition is incomplete because processes create results and not necessarily by transforming inputs. Still, it is not clear what description of process can embed transfo...

  14. Parallel and distributed processing: applications to power systems

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Felix; Murphy, Liam [California Univ., Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences

    1994-12-31

    Applications of parallel and distributed processing to power systems problems are still in the early stages. Rapid progress in computing and communications promises a revolutionary increase in the capacity of distributed processing systems. In this paper, the state-of-the art in distributed processing technology and applications is reviewed and future trends are discussed. (author) 14 refs.,1 tab.

  15. Continuous-time Markov decision processes theory and applications

    CERN Document Server

    Guo, Xianping

    2009-01-01

    This volume provides the first book entirely devoted to recent developments on the theory and applications of continuous-time Markov decision processes (MDPs). The MDPs presented here include most of the cases that arise in applications.

  16. Application and industrialization of irradiation processing technique

    International Nuclear Information System (INIS)

    Irradiation processing technique is a new processing technique. At present, there are 40 sets of electron accelerators have been built or are building for industry are, total power comes to 1436 kw. The products provided have been 8 types and several ten kinds. Current status of radiation processing technique at home and abroad are reviewed

  17. Poisson point processes and their application to Markov processes

    CERN Document Server

    Itô, Kiyosi

    2015-01-01

    An extension problem (often called a boundary problem) of Markov processes has been studied, particularly in the case of one-dimensional diffusion processes, by W. Feller, K. Itô, and H. P. McKean, among others. In this book, Itô discussed a case of a general Markov process with state space S and a specified point a ∈ S called a boundary. The problem is to obtain all possible recurrent extensions of a given minimal process (i.e., the process on S \\ {a} which is absorbed on reaching the boundary a). The study in this lecture is restricted to a simpler case of the boundary a being a discontinuous entrance point, leaving a more general case of a continuous entrance point to future works. He established a one-to-one correspondence between a recurrent extension and a pair of a positive measure k(db) on S \\ {a} (called the jumping-in measure and a non-negative number m< (called the stagnancy rate). The necessary and sufficient conditions for a pair k, m was obtained so that the correspondence is precisely de...

  18. Parallelism and Scalability in an Image Processing Application

    DEFF Research Database (Denmark)

    Rasmussen, Morten Sleth; Stuart, Matthias Bo; Karlsson, Sven

    2009-01-01

    parallel programs. This paper investigates parallelism and scalability of an embedded image processing application. The major challenges faced when parallelizing the application were to extract enough parallelism from the application and to reduce load imbalance. The application has limited immediately......The recent trends in processor architecture show that parallel processing is moving into new areas of computing in the form of many-core desktop processors and multi-processor system-on-chips. This means that parallel processing is required in application areas that traditionally have not used...

  19. Business Process Management Theory and Applications

    CERN Document Server

    2013-01-01

    Business Process Management (BPM) has been in existence for decades. It  uses, complements, integrates and extends theories, methods and tools from  other scientific disciplines like: strategic management, information technology, managerial accounting, operations management etc. During this period the main focus themes of researchers and professionals in BPM  were: business process modeling, business process analysis, activity based costing, business process simulation, performance measurement, workflow management, the link between information technology and BPM for process automation etc. More recently the focus moved to subjects like Knowledge Management, Enterprise Resource Planning (ERP) Systems, Service Oriented Architectures (SOAs), Process Intelligence (PI) and even  Social Networks. In this collection of papers we present a review of the work and the outcomes achieved in the classic BPM fields as well as a deeper insight on recent advances in BPM. We present a review of business process modeling a...

  20. Specifying Processes: Application to Electrical Power Distribution

    Directory of Open Access Journals (Sweden)

    Sabah Al-Fedaghi

    2011-01-01

    Full Text Available Problem statement: This study deals with the problem of how to specify processes. Many process specification methodologies have been determined to be incomplete; for example, ISO 9000:2005 defines process as transforming media inputs into outputs. Nevertheless, the author of the Quality Systems Handbook, declares that such a definition is incomplete because processes create results and not necessarily by transforming inputs. Still, it is not clear what description of process can embed transformation of input to output or include creation that leads to results. Approach: This problem is important because process specification is an essential component in building projects utilized in such tasks as scheduling, planning, production, management, work flow and reengineering. Results: We solve the problem by “opening” the black box in the input-transformation-output model. This action uncovers many possible sources and destinations related to input and output, such as the disappearance, storage and copying of input. It is possible to reject input and also to block output from leaving the process. The approach is based on a conceptual framework for process specification of all generic phases that make up any process and embraces input, transformation, creation and output. The study applies the method in the field of electrical power distribution systems. Conclusion: We conclude that the results demonstrate a viable specification method that can be adopted for different types of processes.

  1. Institute of Plastics Processing and Application of Light Industry

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Institute of Plastics Processing and processing center sponsored by UNDP. University. Application of Light Industry was Since 1999, it has been attached set up in 1983, based on the plastics to Beijing Technology and Business

  2. The Application of Computers to Library Technical Processing

    Science.gov (United States)

    Veaner, Allen B.

    1970-01-01

    Describes computer applications to acquisitions and technical processing and reports in detail on Stanford's development work in automated technical processing. Author is Assistant Director for Bibliographic Operation, Stanford University Libraries. (JB)

  3. Integrating Autonomic Grid Components and Process-Driven Business Applications

    Science.gov (United States)

    Weigold, Thomas; Aldinucci, Marco; Danelutto, Marco; Getov, Vladimir

    Today's business applications are increasingly process driven, meaning that the main application logic is executed by a dedicate process engine. In addition, component-oriented software development has been attracting attention for building complex distributed applications. In this paper we present the experiences gained from building a process-driven biometric identification application which makes use of Grid infrastructures via the Grid Component Model (GCM). GCM, besides guaranteeing access to Grid resources, supports autonomic management of notable parallel composite components. This feature is exploited within our biometric identification application to ensure real time identification of fingerprints. Therefore, we briefly introduce the GCM framework and the process engine used, and we describe the implementation of the application using autonomic GCM components. Finally, we summarize the results, experiences, and lessons learned focusing on the integration of autonomic GCM components and the process-driven approach.

  4. Computer Applications in the Design Process.

    Science.gov (United States)

    Winchip, Susan

    Computer Assisted Design (CAD) and Computer Assisted Manufacturing (CAM) are emerging technologies now being used in home economics and interior design applications. A microcomputer in a computer network system is capable of executing computer graphic functions such as three-dimensional modeling, as well as utilizing office automation packages to…

  5. Positive trigonometric polynomials and signal processing applications

    CERN Document Server

    Dumitrescu, Bogdan

    2007-01-01

    Presents the results on positive trigonometric polynomials within a unitary framework; the theoretical results obtained partly from the general theory of real polynomials, partly from self-sustained developments. This book provides information on the theory of sum-of-squares trigonometric polynomials in two parts: theory and applications.

  6. 13 CFR 400.205 - Application process.

    Science.gov (United States)

    2010-01-01

    ... closing date and time. A postmark is not sufficient to meet this deadline as the application must be... the Board; (6) A certification by the Lender that the Lender meets each of the requirements of the... is not otherwise available to the borrower under reasonable terms or conditions sufficient to...

  7. 13 CFR 500.205 - Application process.

    Science.gov (United States)

    2010-01-01

    ... February 27, 2000, is not sufficient to meet this deadline as the application must be received by the... Borrower meet each of the requirements of the Program as set forth in the Act and the Board's rules in this... reasonable terms or conditions sufficient to meet its financial needs, as reflected in the financial...

  8. Application of Knowledge Management in Customer Relationship Management Processes

    OpenAIRE

    Vahid Majazi Dalfard; Ahmad Jafari; Tohid Alizadeh

    2012-01-01

    Customer relationship management processes can be considered as processes with knowledge increase that their performance is affected by providing knowledge of product, markets and customers. So, using knowledge management capabilities result in taking advantage through customer knowledge flow in the processes. This article addresses knowledge management applications in customer relationship management processes. Studies showed that in general organizations use customers knowledge in customer ...

  9. Application of pyrolysis process in processing of mixed food wastes

    Directory of Open Access Journals (Sweden)

    Grycová Barbora

    2016-03-01

    Full Text Available The food industry produces large amounts of solid and also liquid wastes. Different waste materials and their mixtures were pyrolysed in the laboratory pyrolysis unit to a final temperature of 800°C with a 10 minute delay at the final temperature. After the pyrolysis process of the selected wastes a mass balance of the resulting products, off-line analysis of the pyrolysis gas and evaluation of solid and liquid products were carried out. The highest concentration of methane, hydrogen and carbon monoxide were analyzed during the 4th gas sampling at a temperature of approx. 720–780°C. The concentration of hydrogen was measured in the range from 22 to 40 vol.%. The resulting iodine numbers of samples CHFO, DS, DSFW reach values that indicate the possibility of using them to produce the so-called “disposable sorbents” in wastewater treatment. The WC condensate can be directed to further processing and upgrading for energy use.

  10. 7 CFR 1942.2 - Processing applications.

    Science.gov (United States)

    2010-01-01

    ....2. (iii) State intergovernmental review comments and recommendations (clearinghouse comments). (iv... as financial statements, audits, or copies of organizational documents or existing debt instruments... intergovernmental review process and give full consideration to their comments when selecting preapplications to...

  11. Advances in the Application of Image Processing Fruit Grading

    OpenAIRE

    Fang, Chengjun; Hua, Chunjian

    2013-01-01

    In the perspective of actual production, the paper presents the advances in the application of image processing fruit grading from several aspects, such as processing precision and processing speed of image processing technology. Furthermore, the different algorithms about detecting size, shape, color and defects are combined effectively to reduce the complexity of each algorithm and achieve a balance between the processing precision and processing speed are keys to automatic apple grading.

  12. Aspects Concerning the Optimization of Authentication Process for Distributed Applications

    OpenAIRE

    Ion Ivan; Mihai Doinea; Dragos Palaghita

    2008-01-01

    There will be presented the types of distributed applications. The quality characteristics for distributed applications will be analyzed. There will be established the ways to assign access rights. The authentication category will be analyzed. We will propose an algorithm for the optimization of authentication process. For the application “Evaluation of TIC projects” the algorithm proposed will be applied.

  13. 24 CFR 599.201 - Initiation of application process.

    Science.gov (United States)

    2010-04-01

    ... the nomination process for Renewal Communities, HUD will publish a notice inviting applications for... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Initiation of application process... HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES RENEWAL COMMUNITIES Procedures for Nomination...

  14. 40 CFR 130.15 - Processing application for Indian tribes.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Processing application for Indian tribes. 130.15 Section 130.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY PLANNING AND MANAGEMENT § 130.15 Processing application for Indian tribes....

  15. 12 CFR 926.5 - Housing associate application process.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Housing associate application process. 926.5 Section 926.5 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK MEMBERS AND HOUSING ASSOCIATES FEDERAL HOME LOAN BANK HOUSING ASSOCIATES § 926.5 Housing associate application process....

  16. The emerge of a new superbug gene blaNDM-1

    Institute of Scientific and Technical Information of China (English)

    Wang Kaiji

    2011-01-01

    @@ NDM-- 1 in detail: NDM-1, which is the abbreviation of 'New Delhi metallo-beta-lactamase', is a recently dis-covered enzyme that is produced by some gram-negative Enterobaeteriaceae such as E coil (Esehe-riehia toll) and Klebsiella pneumonia.It is named after 'New Delhi', which is the capital of India, be-cause the first patient who was diagnosed to be colo-nized by bacteria with blaNDM-1 gene had gone toa hospital in New Delhi for cosmetic surgery not long before he was diagnosed.

  17. Genetic environments of the transferable plasmid-mediated blaCTX-M-3 gene in Serratia marcescens isolates.

    Science.gov (United States)

    Chu, Pei-Yu; Peng, Chien-Fang

    2014-01-01

    In this study, genetic environments of the transferable plasmid-mediated blaCTX-M-3 gene were characterized among 14 isolates of cefotaxime-resistant Serratia marcescens using PCR and BLAST DNA sequence analysis. A total of 3 types of genetic architectures in the regions surrounding this blaCTX-M-3 gene were identified. Type I architecture was characterized by the presence of a complete insertion sequence of tnpA-ISEcp1, identified as interrupting a reverse IS26 sequence in the upstream region of the blaCTX-M-3 gene. A reverse-directional orf477 fragment was located downstream of the blaCTX-M-3 gene, which was in the same direction of the mucA gene. A common region containing the orf513 element was located upstream of the mucA gene. Moreover, a copy of the 3'-CS2 element was located immediately upstream of the orf513 element. A novel complex class 1 integron was characterized by the presence of the dfrA19 gene, which was flanked by two copies of class 1 integrons. This is the first report to describe the dfrA19 gene within a novel complex class 1 integron in S. marcescens isolates from Taiwan. This novel complex class 1 integron structure was located distantly upstream of the blaCTX-M-3 gene.

  18. Characterization of a novel plasmid type and various genetic contexts of bla OXA-58 in Acinetobacter spp. from multiple cities in China.

    Directory of Open Access Journals (Sweden)

    Yiqi Fu

    Full Text Available BACKGROUND/OBJECTIVE: Several studies have described the epidemiological distribution of blaOXA-58-harboring Acinetobacter baumannii in China. However, there is limited data concerning the replicon types of blaOXA-58-carrying plasmids and the genetic context surrounding blaOXA-58 in Acinetobacter spp. in China. METHODOLOGY/PRINCIPAL FINDINGS: Twelve non-duplicated blaOXA-58-harboring Acinetobacter spp. isolates were collected from six hospitals in five different cities between 2005 and 2010. The molecular epidemiology of the isolates was carried out using PFGE and multilocus sequence typing. Carbapenemase-encoding genes and plasmid replicase genes were identified by PCR. The genetic location of blaOXA-58 was analyzed using S1-nuclease method. Plasmid conjugation and electrotransformation were performed to evaluate the transferability of blaOXA-58-harboring plasmids. The genetic structure surrounding blaOXA-58 was determined by cloning experiments. The twelve isolates included two Acinetobacter pittii isolates (belong to one pulsotype, three Acinetobacter nosocomialis isolates (belong to two pulsotypes and seven Acinetobacter baumannii isolates (belong to two pulsotypes/sequence types. A. baumannii ST91 was found to be a potential multidrug resistant risk clone carrying both blaOXA-58 and blaOXA-23. blaOXA-58 located on plasmids varied from ca. 52 kb to ca. 143 kb. All plasmids can be electrotransformed to A. baumannii recipient, but were untypeable by the current replicon typing scheme. A novel plasmid replicase named repAci10 was identified in blaOXA-58-harboring plasmids of two A. pittii isolates, three A. nosocomialis isolates and two A. baumannii isolates. Four kinds of genetic contexts of blaOXA-58 were identified. The transformants of plasmids with structure of IS6 family insertion sequence (ISOur1, IS1008 or IS15-ΔISAba3-like element-blaOXA-58 displayed carbapenem nonsusceptible, while others with structure of intact ISAba3-like element-bla

  19. Laser Processing of Materials Fundamentals, Applications and Developments

    CERN Document Server

    Schaaf, Peter

    2010-01-01

    Laser materials processing has made tremendous progress and is now at the forefront of industrial and medical applications. The book describes recent advances in smart and nanoscaled materials going well beyond the traditional cutting and welding applications. As no analytical methods are described the examples are really going into the details of what nowadways is possible by employing lasers for sophisticated materials processing giving rise to achievements not possible by conventional materials processing.

  20. Geopolymers: Structures, Processing, Properties and Industrial applications

    Energy Technology Data Exchange (ETDEWEB)

    Provis, J.L.; van Deventer, J.S.J. (eds.) [University of Melbourne, Vic. (Australia)

    2009-06-15

    A geopolymer is a solid aluminosilicate material usually formed by alkali hydroxide or alkali silicate activation of a solid precursor such as coal fly ash, calcined clay and/or metallurgical slag. Part one discusses the synthesis and characterisation of geopolymers with chapters on topics such as fly ash chemistry and inorganic polymer cements, geopolymer precursor design, nanostructure/microstructure of metakaolin and fly ash geopolymers, and geopolymer synthesis kinetics. Part two reviews the manufacture and properties of geopolymers including accelerated ageing of geopolymers, chemical durability, engineering properties of geopolymer concrete, producing fire and heat-resistant geopolymers, utilisation of mining wastes and thermal properties of geopolymers. Part three covers applications of geopolymers with coverage of topics such as commercialisation of geopolymers for construction, as well as applications in waste management. Chapters of particular relevance are: Fly ash glass chemistry and inorganic polymer cements by L.M. Keyte, University of Melbourne, Australia; Nanostructure/microstructure of metakaolin geopolymers by A. Fernanez-Jimenez and A. Palomo, Eduardo Torroja Institute, Spain; Utilisation of mining wastes to produce geopolymer binders by F. Pacheco-Torgal and S. Jalali, University of Minho and J.P. Castro-Gomes, University of Beira Interior, Portugal.

  1. Signal and image processing in medical applications

    CERN Document Server

    Kumar, Amit; Rahim, B Abdul; Kumar, D Sravan

    2016-01-01

    This book highlights recent findings on and analyses conducted on signals and images in the area of medicine. The experimental investigations involve a variety of signals and images and their methodologies range from very basic to sophisticated methods. The book explains how signal and image processing methods can be used to detect and forecast abnormalities in an easy-to-follow manner, offering a valuable resource for researchers, engineers, physicians and bioinformatics researchers alike.

  2. Metrology Sampling Strategies for Process Monitoring Applications

    KAUST Repository

    Vincent, Tyrone L.

    2011-11-01

    Shrinking process windows in very large scale integration semiconductor manufacturing have already necessitated the development of control systems capable of addressing sub-lot-level variation. Within-wafer control is the next milestone in the evolution of advanced process control from lot-based and wafer-based control. In order to adequately comprehend and control within-wafer spatial variation, inline measurements must be performed at multiple locations across the wafer. At the same time, economic pressures prompt a reduction in metrology, for both capital and cycle-time reasons. This paper explores the use of modeling and minimum-variance prediction as a method to select the sites for measurement on each wafer. The models are developed using the standard statistical tools of principle component analysis and canonical correlation analysis. The proposed selection method is validated using real manufacturing data, and results indicate that it is possible to significantly reduce the number of measurements with little loss in the information obtained for the process control systems. © 2011 IEEE.

  3. Application to the radiation processing of polymer

    Energy Technology Data Exchange (ETDEWEB)

    Yoshii, Fumio [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

    2003-02-01

    Polypropylene (PP) and biodegradable polymer (blend of poly ({epsilon}-caploracton) 30/polybutylenesuccynate 70), PHB02 were irradiated with an electron beam to improve processability for production of thin film and foam. The processability of the polymer was improved due to enhancement of melt strength with irradiation at the dose range between 10 and 100 kGy. Increase of melt strength is due to entanglement of branch structure formed by irradiation. Possibility of high-speed production of thin film and production of foam have been achieved by this process. The soil degradation test showed that biodegradable polymer film buried in the soil was almost entirely degraded (97%) after two months and completely degraded after two and a half months. In the case of foam samples, 65% degradation was achieved after four months. Radiation crosslinked water-soluble polymer form hydrogel, which absorb much water. The hydrogel prepared by irradiation of polymer in aqueous solution was applied as dressing for healing of wound. In order to evaluate the healing effect of the polyethylene oxide (PEO) hydrogel dressing, wounds formed on the back of marmots were covered by the hydrogel. The healing under the wet environment of the hydrogel dressing had three advantages, compared with that of gauze dressing, which gives a dry environment: (1) enhancement of healing rate, (2) facilitation for changing the dressing, i.e. the hydrogel can be peeled off without any damage to the regenerated skin surface, and (3) hydrogel dressing material does not remain stuck on the wound. (author)

  4. Application to the radiation processing of polymer

    International Nuclear Information System (INIS)

    Polypropylene (PP) and biodegradable polymer (blend of poly (ε-caploracton) 30/polybutylenesuccynate 70), PHB02 were irradiated with an electron beam to improve processability for production of thin film and foam. The processability of the polymer was improved due to enhancement of melt strength with irradiation at the dose range between 10 and 100 kGy. Increase of melt strength is due to entanglement of branch structure formed by irradiation. Possibility of high-speed production of thin film and production of foam have been achieved by this process. The soil degradation test showed that biodegradable polymer film buried in the soil was almost entirely degraded (97%) after two months and completely degraded after two and a half months. In the case of foam samples, 65% degradation was achieved after four months. Radiation crosslinked water-soluble polymer form hydrogel, which absorb much water. The hydrogel prepared by irradiation of polymer in aqueous solution was applied as dressing for healing of wound. In order to evaluate the healing effect of the polyethylene oxide (PEO) hydrogel dressing, wounds formed on the back of marmots were covered by the hydrogel. The healing under the wet environment of the hydrogel dressing had three advantages, compared with that of gauze dressing, which gives a dry environment: (1) enhancement of healing rate, (2) facilitation for changing the dressing, i.e. the hydrogel can be peeled off without any damage to the regenerated skin surface, and (3) hydrogel dressing material does not remain stuck on the wound. (author)

  5. Applications of Friction Stir Processing during Engraving of Soft Materials

    Directory of Open Access Journals (Sweden)

    V. Kočović

    2015-12-01

    Full Text Available Friction stir processing has extensive application in many technological operations. Application area of friction stir processing can be extended to the processing of non-metallic materials, such as wood. The paper examines the friction stir processing contact between a specially designed hard and temperature-resistant rotating tool and workpiece which is made of wood. Interval of speed slip and temperature level under which the combustion occurs and carbonization layer of soft material was determined. The results of the research can be applied in technological process of wood engraving operations which may have significant technological and aesthetic effects.

  6. Application of simulation models for the optimization of business processes

    Science.gov (United States)

    Jašek, Roman; Sedláček, Michal; Chramcov, Bronislav; Dvořák, Jiří

    2016-06-01

    The paper deals with the applications of modeling and simulation tools in the optimization of business processes, especially in solving an optimization of signal flow in security company. As a modeling tool was selected Simul8 software that is used to process modeling based on discrete event simulation and which enables the creation of a visual model of production and distribution processes.

  7. Spacetime Processing Metasurfaces: GSTC Synthesis and Prospective Applications

    CERN Document Server

    Chamanara, Nima; Achouri, Karim; Caloz, Christophe

    2016-01-01

    The paper presents the general concept of spacetime processing metasurfaces, synthesized by generalized sheet transition conditions (GSTCs). It is shown that such metasurfaces can perform multiple simultaneous spatio-temporal processing transformations on incident electromagnetic waves. A time-reversal space-generalized-refraction metasurface and a multi-time-space-differentiating metasurfaces are presented as applications of the general spacetime processing metasurface concept.

  8. Digital signal processing fundamentals and applications

    CERN Document Server

    Tan, Li

    2013-01-01

    Digital Signal Processing, Second Edition enables electrical engineers and technicians in the fields of biomedical, computer, and electronics engineering to master the essential fundamentals of DSP principles and practice. Many instructive worked examples are used to illustrate the material, and the use of mathematics is minimized for easier grasp of concepts. As such, this title is also useful to undergraduates in electrical engineering, and as a reference for science students and practicing engineers. The book goes beyond DSP theory, to show implementation of algorithms in hardware

  9. Emergence of Acinetobacter baumannii ST730 carrying the bla OXA-72 gene in Brazil

    Science.gov (United States)

    Pagano, Mariana; Rozales, Franciéli P; Bertolini, Diego; Rocha, Lisiane; Sampaio, Jorge LM; Barth, Afonso L; Martins, Andreza F

    2016-01-01

    Over the last decade, Acinetobacter baumannii resistant to carbapenems has emerged in many medical centres and has been commonly associated with high morbimortality. In Brazil, this resistance is mainly attributed to the spread of OXA-23-producing clones and, to a lesser extent, to OXA-143-producing clones. Here, we describe, for the first time, two OXA-72-producing A. baumannii isolates in southern Brazil to a broad spectrum of antibiotics, except polymyxin B and tigecycline. Molecular typing by multilocus sequence typing (MLST) demonstrated that both OXA-72-producing isolates belong to a new sequence type (ST), ST730, which was recently identified in OXA-23-producing A. baumannii isolates in São Paulo, Brazil. We demonstrate that the two A. baumannii ST730 isolates carrying blaOXA-72share a common ancestral origin with the blaOXA-23producers in Brazil. This observation reinforces the importance of strain-typing methods in order to clarify the dynamics of the emergence of new clones in a geographic region. PMID:27653364

  10. Virulence of Klebsiella pneumoniae isolates harboring bla KPC-2 carbapenemase gene in a Caenorhabditis elegans model.

    Directory of Open Access Journals (Sweden)

    Jean-Philippe Lavigne

    Full Text Available Klebsiella pneumoniae carbapenemase (KPC is a carbapenemase increasingly reported worldwide in Enterobacteriaceae. The aim of this study was to analyze the virulence of several KPC-2-producing K. pneumoniae isolates. The studied strains were (i five KPC-2 clinical strains from different geographical origins, belonging to different ST-types and possessing plasmids of different incompatibility groups; (ii seven transformants obtained after electroporation of either these natural KPC plasmids or a recombinant plasmid harboring only the bla KPC-2 gene into reference strains K. pneumoniae ATCC10031/CIP53153; and (iii five clinical strains cured of plasmids. The virulence of K. pneumoniae isolates was evaluated in the Caenorhabditis elegans model. The clinical KPC producers and transformants were significantly less virulent (LT50: 5.5 days than K. pneumoniae reference strain (LT50: 4.3 days (p<0.01. However, the worldwide spread KPC-2 positive K. pneumoniae ST258 strains and reference strains containing plasmids extracted from K. pneumoniae ST258 strains had a higher virulence than KPC-2 strains belonging to other ST types (LT50: 5 days vs. 6 days, p<0.01. The increased virulence observed in cured strains confirmed this trend. The bla KPC-2 gene itself was not associated to increased virulence.

  11. The Delphi process: a solution for reviewing novel grant applications

    Directory of Open Access Journals (Sweden)

    Cath Holliday

    2010-08-01

    Full Text Available Cath Holliday1, Monica Robotin1,21Cancer Council New South Wales, Sydney; 2University of Sydney, School of Public Health, Sydney, New South Wales, AustraliaIntroduction: Traditional scientific review processes are not well suited for evaluating the merits of research in situations where the available scientific evidence is limited and if review panels have widely divergent opinions. This study tested whether a Delphi process is useful in grant selection.Materials and method: A Delphi process prioritized novel research proposals in pancreatic cancer. Five reviewers holding similar grants overseas ranked research applications by scientific merit, innovativeness, and level of risk.Result: Three rounds of voting evaluated the best 10 applications received. In the first round of the Delphi process, scores ranged from 5.0 to 8.3. After the second round, the cumulative scores of the eight remaining applications ranged from 10 to 12.6. At the end of the third round, the final cumulative scores of the remaining six applications ranged from 13.6 to 18.2. The four highest ranking applications were recommended for funding, with agreement from reviewers.Conclusion: A modified Delphi process proved to be an efficient, transparent, and equitable method of reviewing novel grant applications in a specialized field of research, where no local expertise was available. This process may also be useful for other peer review processes, particularly where there is limited access to local experts.Keywords: delphi process, research grant selection, consensus

  12. Molecular typing and genetic environment of the blaKPC gene in Chilean isolates of Klebsiella pneumoniae.

    Science.gov (United States)

    Barría-Loaiza, Carla; Pincheira, Andrea; Quezada, Mario; Vera, Alejandra; Valenzuela, Pedro; Domínguez, Mariana; Lima, Celia A; Araya, Ingrid; Araya, Pamela; Prat, Soledad; Aguayo, Carolina; Fernández, Jorge; Hormazábal, Juan Carlos; Bello-Toledo, Helia; González-Rocha, Gerardo

    2016-03-01

    The aim of this work was to determine the genetic environment and transferability of blaKPC as well as the pulsotypes of KPC-producing Klebsiella pneumoniae strains isolated from clinical samples in Chilean hospitals. Seventeen strains, principally isolated in Santiago (the capital of Chile) during the years 2012 and 2013, were included. The genetic environment of blaKPC was elucidated by PCR mapping and sequencing. Molecular typing was performed by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). Curing and conjugation experiments were performed with six strains of different sequence types (STs) and pulsotypes. Thirteen pulsotypes and six STs, mainly belonging to clonal complex 258, were found. In addition, seven strains belonged to a new ST assigned ST1161. The blaKPC sequence indicated that 16 strains had the KPC-2 variant; in only one strain (UC331) an amino acid change (R6P) was detected, corresponding to a new KPC variant designated KPC-24. Molecular characterisation of the blaKPC genetic environment revealed two distinct platforms, namely variant 1a and the Tn4401a isoform, with the first being the most common (11/17 strains). Mating experiments failed to produce transconjugants; however, loss of blaKPC was achieved by plasmid curing in all assayed strains. In conclusion, in Chilean strains of K. pneumoniae, blaKPC is primarily found associated with the variant 1a and is located in non-transferable plasmids. In addition, this study highlights the description of the new ST1161 and the new KPC-24 variant. PMID:27436389

  13. Further Spread of bla NDM-5 in Enterobacteriaceae via IncX3 Plasmids in Shanghai, China.

    Science.gov (United States)

    Zhang, Fangfang; Xie, Lianyan; Wang, Xiaoli; Han, Lizhong; Guo, Xiaokui; Ni, Yuxing; Qu, Hongping; Sun, Jingyong

    2016-01-01

    One hundred and two carbapenem-resistant Enterobacteriaceae (CRE) strains were isolated in a teaching hospital in Shanghai, China from 2012 to 2015. In a follow-up study, four New Delhi metallo-β-lactamase-5 (NDM-5)-producing strains were identified after screening these CRE strains, including 1 Klebsiella pneumoniae strain (RJ01), 1 Proteus mirabilis strain (RJ02), and 2 Escherichia coli strains (RJ03 and RJ04). All K. pneumoniae and E. coli isolates were resistant to carbapenems, third-generation cephalosporins, and piperacillin-tazobactam, but were susceptible to amikacin. No epidemiological links for either E. coli isolate were found by multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE). However, MLST revealed a novel sequence type, ST2250, of the K. pneumoniae RJ01 strain. Inc types and sizes of bla NDM-5-carrying plasmids differed among the four isolates, although in P. mirabilis RJ02 and E. coli RJ03, bla NDM-5 was carried by conjugative IncX3 plasmids of nearly the same size (∼40 kb). Investigation of the genetic background of sequences flanking the bla NDM-5 gene showed that all four isolates shared the same genetic content (IS3000-ΔISAba125-IS5-bla NDM-5-ble-trpF-dsbC-IS26-ΔumuD), which was identical to that of the pNDM_MGR194 plasmid circulating in India. This is the first identification of bla NDM-5 in P. mirabilis, which suggests its further spread to Enterobacteriaceae, and indicates that IncX3 plasmids may play an important role in potentiating the spread of bla NDM. PMID:27065982

  14. Molecular typing and genetic environment of the blaKPC gene in Chilean isolates of Klebsiella pneumoniae.

    Science.gov (United States)

    Barría-Loaiza, Carla; Pincheira, Andrea; Quezada, Mario; Vera, Alejandra; Valenzuela, Pedro; Domínguez, Mariana; Lima, Celia A; Araya, Ingrid; Araya, Pamela; Prat, Soledad; Aguayo, Carolina; Fernández, Jorge; Hormazábal, Juan Carlos; Bello-Toledo, Helia; González-Rocha, Gerardo

    2016-03-01

    The aim of this work was to determine the genetic environment and transferability of blaKPC as well as the pulsotypes of KPC-producing Klebsiella pneumoniae strains isolated from clinical samples in Chilean hospitals. Seventeen strains, principally isolated in Santiago (the capital of Chile) during the years 2012 and 2013, were included. The genetic environment of blaKPC was elucidated by PCR mapping and sequencing. Molecular typing was performed by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). Curing and conjugation experiments were performed with six strains of different sequence types (STs) and pulsotypes. Thirteen pulsotypes and six STs, mainly belonging to clonal complex 258, were found. In addition, seven strains belonged to a new ST assigned ST1161. The blaKPC sequence indicated that 16 strains had the KPC-2 variant; in only one strain (UC331) an amino acid change (R6P) was detected, corresponding to a new KPC variant designated KPC-24. Molecular characterisation of the blaKPC genetic environment revealed two distinct platforms, namely variant 1a and the Tn4401a isoform, with the first being the most common (11/17 strains). Mating experiments failed to produce transconjugants; however, loss of blaKPC was achieved by plasmid curing in all assayed strains. In conclusion, in Chilean strains of K. pneumoniae, blaKPC is primarily found associated with the variant 1a and is located in non-transferable plasmids. In addition, this study highlights the description of the new ST1161 and the new KPC-24 variant.

  15. Dissemination of IncI2 Plasmids That Harbor the blaCTX-M Element among Clinical Salmonella Isolates.

    Science.gov (United States)

    Wong, Marcus Ho-Yin; Liu, Lizhang; Yan, Meiying; Chan, Edward Wai-Chi; Chen, Sheng

    2015-08-01

    The extended-spectrum-β-lactamase (ESBL) determinant CTX-M-55 is increasingly prevalent in Escherichia coli but remains extremely rare in Salmonella. This study reports the isolation of a plasmid harboring the blaCTX-M-55 element in a clinical Salmonella enterica serotype Typhimurium strain resistant to multiple antibiotics. This plasmid is genetically identical to several known IncI2-type elements harbored by E. coli strains recovered from animals. This finding indicates that IncI2 plasmids harboring the blaCTX-M genes may undergo cross-species migration among potential bacterial pathogens, with E. coli as the major source of such elements. PMID:26014934

  16. Applications of sonochemistry in Russian food processing industry.

    Science.gov (United States)

    Krasulya, Olga; Shestakov, Sergey; Bogush, Vladimir; Potoroko, Irina; Cherepanov, Pavel; Krasulya, Boris

    2014-11-01

    In food industry, conventional methodologies such as grinding, mixing, and heat treatment are used for food processing and preservation. These processes have been well studied for many centuries and used in the conversion of raw food materials to consumable food products. This report is dedicated to the application of a cost-efficient method of energy transfer caused by acoustic cavitation effects in food processing, overall, having significant impacts on the development of relatively new area of food processing such as food sonochemistry.

  17. Application of microorganisms in coal cleaning processes

    International Nuclear Information System (INIS)

    A secure energy supply is one of the basic pre-requisites for a sound economic system, sustained standard and quality of life and eventually for the social well-being of each individual. For a progressive country like Pakistan, it is obligatory that all energy options must be pursued vigorously including coal utilization, which given the relatively large resources available, is considered to be one of the major options for the next few hundred years. Bioprocessing of coal in an emerging technology which has started to receive considerable research attention. Recent research activities involving coal cleaning, direct coal conversion, and indirect conversion of coal-derived materials have generated a plethora of facts regarding biochemistry, chemistry, and thermodynamic behavior of coal, in that its bioprocessing is on the verge of becoming and acceptable means to great coals. In this research report, investigations pertaining to the various aspects of coal bio processing, including desulfurization and depyritization are discussed. Bituminous coals varying in total sulfur contents of 3-6% were depyritized more than 90% by mesophilic acidophiles like Thiobacillus ferroxidans and Thiobacillus thio oxidans and thermophilic Sulfolobus brierleyi. The archaebacterium, Sulfolobus brierleyi was found to desulfurize inorganic and organic sulfur components of the coal. Conditions were established under which it can remove more than 30% of the organic sulfur present in the coals. Heterotrophic microorganisms including oxenic and soil isolates were also employed for studying sulfurization. A soil isolate, Oil-2, was found to remove more than 70% dibenzothiophenic sulfur present in an oil-water emulsion (1:20 ratio). Pseudomonas putida and the bacterium oil-2 also remove 60-70% organic sulfur present in the shale-oil. Preliminary results indicate the presence of putatively known Kodama's pathway in the oil-2. The mass balance for sulfate indicated the possibility of the presence

  18. Plan for advanced microelectronics processing technology application

    Energy Technology Data Exchange (ETDEWEB)

    Goland, A.N.

    1990-10-01

    The ultimate objective of the tasks described in the research agreement was to identify resources primarily, but not exclusively, within New York State that are available for the development of a Center for Advanced Microelectronics Processing (CAMP). Identification of those resources would enable Brookhaven National Laboratory to prepare a program plan for the CAMP. In order to achieve the stated goal, the principal investigators undertook to meet the key personnel in relevant NYS industrial and academic organizations to discuss the potential for economic development that could accompany such a Center and to gauge the extent of participation that could be expected from each interested party. Integrated of these discussions was to be achieved through a workshop convened in the summer of 1990. The culmination of this workshop was to be a report (the final report) outlining a plan for implementing a Center in the state. As events unfolded, it became possible to identify the elements of a major center for x-ray lithography on Lone Island at Brookhaven National Laboratory. The principal investigators were than advised to substitute a working document based upon that concept in place of a report based upon the more general CAMP workshop originally envisioned. Following that suggestion from the New York State Science and Technology Foundation, the principals established a working group consisting of representatives of the Grumman Corporation, Columbia University, the State University of New York at Stony Brook, and Brookhaven National Laboratory. Regular meetings and additional communications between these collaborators have produced a preproposal that constitutes the main body of the final report required by the contract. Other components of this final report include the interim report and a brief description of the activities which followed the establishment of the X-ray Lithography Center working group.

  19. High temperature heat exchange: nuclear process heat applications

    International Nuclear Information System (INIS)

    The unique element of the HTGR system is the high-temperature operation and the need for heat exchanger equipment to transfer nuclear heat from the reactor to the process application. This paper discusses the potential applications of the HTGR in both synthetic fuel production and nuclear steel making and presents the design considerations for the high-temperature heat exchanger equipment

  20. 38 CFR 38.632 - Headstone or marker application process.

    Science.gov (United States)

    2010-07-01

    ... following link: http://www.va.gov/vaforms/va/pdf/40-1330.pdf. (d) Application process for new emblems of..., VA will accept as genuine an applicant's statement regarding the sincerity of the religious or..., professional or military emblems. VA will not accept any emblem that would have an adverse impact on...

  1. Bayesian networks applied to process diagnostics. Applications in energy industry

    Energy Technology Data Exchange (ETDEWEB)

    Widarsson, Bjoern (ed.); Karlsson, Christer; Dahlquist, Erik [Maelardalen Univ., Vaesteraas (Sweden); Nielsen, Thomas D.; Jensen, Finn V. [Aalborg Univ. (Denmark)

    2004-10-01

    Uncertainty in process operation occurs frequently in heat and power industry. This makes it hard to find the occurrence of an abnormal process state from a number of process signals (measurements) or find the correct cause to an abnormality. Among several other methods, Bayesian Networks (BN) is a method to build a model which can handle uncertainty in both process signals and the process itself. The purpose of this project is to investigate the possibilities to use BN for fault detection and diagnostics in combined heat and power industries through execution of two different applications. Participants from Aalborg University represent the knowledge of BN and participants from Maelardalen University have the experience from modelling heat and power applications. The co-operation also includes two energy companies; Elsam A/S (Nordjyllandsverket) and Maelarenergi AB (Vaesteraas CHP-plant), where the two applications are made with support from the plant personnel. The project ended out in two quite different applications. At Nordjyllandsverket, an application based (due to the lack of process knowledge) on pure operation data is build with capability to detect an abnormal process state in a coal mill. Detection is made through a conflict analysis when entering process signals into a model built by analysing the operation database. The application at Maelarenergi is built with a combination of process knowledge and operation data and can detect various faults caused by the fuel. The process knowledge is used to build a causal network structure and the structure is then trained by data from the operation database. Both applications are made as off-online applications, but they are ready for being run on-line. The performance of fault detection and diagnostics are good, but a lack of abnormal process states with known cause reduces the evaluation possibilities. Advantages with combining expert knowledge of the process with operation data are the possibility to represent

  2. Ambiente genético del Gen blaCTX-M-12 en aislamientos hospitalarios de Klebsiella pneumoniae

    Directory of Open Access Journals (Sweden)

    Yamile Adriana Celis Bustos

    2009-06-01

    Full Text Available The blaCTX-M-12 gene’s genetic environmnt in Klebsiella pneumoniae hospital isolates Resumen: En Colombia se han detectado genes del grupo CTX-M-1 con alta frecuencia en aislamientos de Klebsiella pneumoniae causantes de infección intrahospitalaria. El conocimiento de los factores genéticos que pueden favorecer la diseminación de estos genes entre especies bacterianas es un aspecto importante para el control de la resistencia. En este estudio se identificaron los plásmidos portadores del gen blaCTX-M-12 en 21 aislamientos clínicos de K. pneumoniae. Se evaluó por conjugación la transferencia de resistencia a antibióticos. Integrones, secuencias de inserción y otros elementos genéticos fueron detectados por amplificación del ADN plasmídico con la reacción en cadena de la polimerasa (PCR. Mediante análisis por PCR se determinó la relación entre el gen blaCTX-M-12 y los elementos genéticos detectados. En todos los aislamientos, el gen blaCTX-M-12 se encontró en plásmidos conjugativos de tamaños entre 65 y 106 kpb. La transferencia por conjugación de estos elementos móviles puede explicar la amplia diseminación de este gen entre enterobacterias causantes de infección nosocomial en hospitales de Bogotá, Colombia. El gen blaCTX-M-12 se encontró corriente abajo de ISEcp1, secuencia de inserción que se ha asociado con la movilización de determinantes genéticos de resistencia. Los promotores de ISEcp1, detectados por análisis de secuencia, pueden facilitar la expresión de la cefotaximasa codificada por este gen.Palabras clave: resistencia a antibióticos; elementos genéticos móviles; gen blaCTX-M-12; plásmidos conjugativos;  Klebsiella pneumoniae. Abstract: Genes from CTX-M-1 group have been detected with great frequency in Colombia in intrahospital infection-causing Klebsiella pneumoniae isolates. Knowledge regarding the genetic factors favouring such genes’ dissemination amongst bacterial species is an

  3. First descriptions of blaKPC in Raoultella spp. (R. planticola and R. ornithinolytica): report from the SENTRY Antimicrobial Surveillance Program.

    Science.gov (United States)

    Castanheira, Mariana; Deshpande, Lalitagauri M; DiPersio, Joseph R; Kang, Julia; Weinstein, Melvin P; Jones, Ronald N

    2009-12-01

    Two strains of Raoultella planticola and one of Raoultella ornithinolytica showing carbapenem resistance were recovered from patients hospitalized in New Jersey and Ohio. All patients had received previous antimicrobial treatment, including carbapenems. These strains harbored bla(KPC-2) and bla(KPC-3). Carbapenemase genes were embedded in isoforms of Tn4401 and were plasmidic and chromosomal in location.

  4. Increased prevalence of carbapenem resistant Enterobacteriaceae in hospital setting due to cross-species transmission of the bla NDM-1 element and clonal spread of progenitor resistant strains.

    Science.gov (United States)

    Wang, Xuan; Chen, Gongxiang; Wu, Xiaoyan; Wang, Liangping; Cai, Jiachang; Chan, Edward W; Chen, Sheng; Zhang, Rong

    2015-01-01

    This study investigated the transmission characteristics of carbapenem-resistant Enterobacteriaceae (CRE) strains collected from a hospital setting in China, in which consistent emergence of CRE strains were observable during the period of May 2013 to February 2014. Among the 45 CRE isolates tested, 21 (47%) strains were found to harbor the bla NDM-1 element, and the rest of 24 CRE strains were all positive for bla KPC-2. The 21 bla NDM-1-borne strains were found to comprise multiple Enterobacteriaceae species including nine Enterobacter cloacae, three Escherichia coli, three Citrobacter freundii, two Klebsiella pneumoniae, two Klebsiella oxytoca, and two Morganella morganii strains, indicating that cross-species transmission of bla NDM-1 is a common event. Genetic analyses by PFGE and MLST showed that, with the exception of E. coli and E. cloacae, strains belonging to the same species were often genetically unrelated. In addition to bla NDM-1, several CRE strains were also found to harbor the bla KPC-2, bla VIM-1, and bla IMP-4 elements. Conjugations experiments confirmed that the majority of carbapenem resistance determinants were transferable. Taken together, our findings suggest that transmission of mobile resistance elements among members of Enterobacteriaceae and clonal spread of CRE strains may contribute synergistically to a rapid increase in the population of CRE in clinical settings, prompting a need to implement more rigorous infection control measures to arrest such vicious transmission cycle in CRE-prevalent areas. PMID:26136735

  5. Thermal storage technologies for solar industrial process heat applications

    Science.gov (United States)

    Gordon, L. H.

    1979-01-01

    The state-of-the-art of thermal storage subsystems for the intermediate and high temperature (100 C to 600 C) solar industrial process heat generation is presented. Primary emphasis is focused on buffering and diurnal storage as well as total energy transport. In addition, advanced thermal storage concepts which appear promising for future solar industrial process heat applications are discussed.

  6. Optical Code Processing System, Device, and its Application

    Directory of Open Access Journals (Sweden)

    Naoya Wada

    2010-02-01

    Full Text Available Recent progress of optical code processing technology_ is explained. Ultra-high speed time domain, spectral domain, hybrid_ domain, and multiple optical code processing deices and systems are shown. As application of these technologies, OCDMA-PON, OPS network, and ultra high-speed optical clock generation will be demonstrated.

  7. MICROSTRUCTURE DEVICES FOR APPLICATIONS IN THERMAL AND CHEMICAL PROCESS ENGINEERING

    OpenAIRE

    Brandner, Juergen; Anurjew, E.; Henning, T.; Schygulla, U.; Schubert, K.

    2006-01-01

    In this publication, an overview of the work dealing with thermal and chemical micro process engineering performed at the Institute for Micro Process Engineering (IMVT) of Forschungszentrum Karlsruhe will be given. The focus will be set on manufacturing of metallic microstructure devices and on microstructure heat exchangers. A brief outlook will describe possible future application fields.

  8. Applications of Fuzzy Logic in Image Processing – A Brief

    Directory of Open Access Journals (Sweden)

    Mahesh Prasanna K

    2015-10-01

    Full Text Available  The subject of this study is to show the application of fuzzy logic in image processing with a brief introduction to fuzzy logic and digital image processing. Digital image processing is an ever expanding and dynamic area with applications reaching out into our everyday life such as medicine, space exploration, surveillance, authentication, automated industry inspection and many more areas. Fuzzy logic, one of the decision-making techniques of artificial intelligence, has many application areas. Although it has been subjected to criticisms since its birth, especially in recent years, fuzzy logic has been proven to be applicable in almost all scientific fields. This shows that the concept of fuzzy logic will maintain its validity and the number of fields where it draws attention will increase further.

  9. Process Planning Support System for Green Manufacturing and its application

    Institute of Scientific and Technical Information of China (English)

    HE Yan; LIU Fei; CAO Huajun; ZHANG Hua

    2007-01-01

    Owing to a lack of practical methods and soft- ware tools in the existing researches on green manufacturing (GM), process planning support system for green manufac- turing (GMPPSS) was developed to deal with the problems in optimization of environment-benign process planning. The GMPPSS consisted mainly of three function modules and related model repositories including: selection of process elements, optimization of process courses, and evaluation of process projects for GM. The database of the GMPPSS was used to provide plentiful information on resources consump- tion and environmental impact in manufacturing processes, which consisted of process attribute database, inventory database, machine database, tool database, and the cutting fluid database. Raw materials, secondary material consump- tion, energy consumption, and environment impacts of pro- cess planning were optimized to improve the green attribute of process planning of parts with the supports of the data- bases and model repositories. The gear processing in the machining tool factory was presented to verify the system's applicability.

  10. Introduction to probability and stochastic processes with applications

    CERN Document Server

    Castañ, Blanco; Arunachalam, Viswanathan; Dharmaraja, Selvamuthu

    2012-01-01

    An easily accessible, real-world approach to probability and stochastic processes Introduction to Probability and Stochastic Processes with Applications presents a clear, easy-to-understand treatment of probability and stochastic processes, providing readers with a solid foundation they can build upon throughout their careers. With an emphasis on applications in engineering, applied sciences, business and finance, statistics, mathematics, and operations research, the book features numerous real-world examples that illustrate how random phenomena occur in nature and how to use probabilistic t

  11. Real-time digital signal processing fundamentals, implementations and applications

    CERN Document Server

    Kuo, Sen M; Tian, Wenshun

    2013-01-01

    Combines both the DSP principles and real-time implementations and applications, and now updated with the new eZdsp USB Stick, which is very low cost, portable and widely employed at many DSP labs. Real-Time Digital Signal Processing introduces fundamental digital signal processing (DSP) principles and will be updated to include the latest DSP applications, introduce new software development tools and adjust the software design process to reflect the latest advances in the field. In the 3rd edition of the book, the key aspect of hands-on experiments will be enhanced to make the DSP principle

  12. Pelletization processes for pharmaceutical applications: a patent review.

    Science.gov (United States)

    Politis, Stavros N; Rekkas, Dimitrios M

    2011-01-01

    Pellets exhibit major therapeutic and technical advantages which have established them as an exceptionally useful dosage form. A plethora of processes and materials is available for the production of pellets, which practically allows inexhaustible configurations contributing to the flexibility and versatility of pellets as drug delivery systems. The scope of this review is to summarize the recent literature on pelletization processes for pharmaceutical applications, focusing on the awarded and pending patents in this technical field. The first part of the article provides an overview of innovation in pelletization processes, while the second part evaluates their novel applications. PMID:21143125

  13. Symmetric Rearrangements Around Infinity with Applications to Levy Processes

    CERN Document Server

    Drewitz, Alexander; Sun, Rongfeng

    2011-01-01

    We prove a new rearrangement inequality for multiple integrals, which partly generalizes a result of Friedberg and Luttinger (1976) and can be interpreted as involving symmetric rearrangements of domains around infinity. As applications, we prove two comparison results for general Levy processes and their symmetric rearrangements. The first application concerns the survival probability of a point particle in a Poisson field of moving traps following independent Levy motions. We show that the survival probability can only increase if the point particle does not move, and the traps and the Levy motions are symmetrically rearranged. This essentially generalizes an isoperimetric inequality of Peres and Sousi (2011) for the Wiener sausage. In the second application, we show that the q-capacity of a Borel measurable set for a Levy process can only increase if the set and the Levy process are symmetrically rearranged. This result generalizes an inequality obtained by Watanabe (1983) for symmetric Levy processes.

  14. Optimizing signal and image processing applications using Intel libraries

    Science.gov (United States)

    Landré, Jérôme; Truchetet, Frédéric

    2007-01-01

    This paper presents optimized signal and image processing libraries from Intel Corporation. Intel Performance Primitives (IPP) is a low-level signal and image processing library developed by Intel Corporation to optimize code on Intel processors. Open Computer Vision library (OpenCV) is a high-level library dedicated to computer vision tasks. This article describes the use of both libraries to build flexible and efficient signal and image processing applications.

  15. Enzyme Applications in Textile Preparatory Process: A Review

    OpenAIRE

    Mojsov, Kiro

    2012-01-01

    Industrial use of biotechnology is bringing about new products and processes aimed at the use of renewable resources, as well as the application og green technologies with low energy consumption and environmentally healthy practices. Textile processing is a growing industry that traditionally has used a lot of water, energy and harsh chemicals. Due to the ever-growing costs for water and energy worldwide investigations are carriedout to substitute conventional chemical textile processes by en...

  16. On digital image processing technology and application in geometric measure

    Science.gov (United States)

    Yuan, Jiugen; Xing, Ruonan; Liao, Na

    2014-04-01

    Digital image processing technique is an emerging science that emerging with the development of semiconductor integrated circuit technology and computer science technology since the 1960s.The article introduces the digital image processing technique and principle during measuring compared with the traditional optical measurement method. It takes geometric measure as an example and introduced the development tendency of digital image processing technology from the perspective of technology application.

  17. Application of TQM principles to the utilization management process.

    Science.gov (United States)

    Miller, J B; Rose, M S; Milakovich, M; Rosasco, E J

    1992-01-01

    Application of the philosophy and principles of TQM and CQI to utilization management within an institution necessitates an in-depth review of the systems and processes of the flow of inpatients throughout their stay. This encompasses a total systems perspective, beginning with the admitting process and going through the discharge process. TQM and CQI philosophies identify that the most significant and costly inefficiencies are due to faulty systems and processes, not individuals. Applying this management strategy to a health care institution requires a detailed review and analysis of processes by which service is delivered and requires evaluation of the outcomes of patient care and patient satisfaction.

  18. Application of Knowledge Management in Customer Relationship Management Processes

    Directory of Open Access Journals (Sweden)

    Vahid Majazi Dalfard

    2012-06-01

    Full Text Available Customer relationship management processes can be considered as processes with knowledge increase that their performance is affected by providing knowledge of product, markets and customers. So, using knowledge management capabilities result in taking advantage through customer knowledge flow in the processes. This article addresses knowledge management applications in customer relationship management processes. Studies showed that in general organizations use customers knowledge in customer portfolio management, developing customer divisions, marketing communications and marketing promotion, product quality, creating a new product, defining commercial processes of customer services, supporting customer communication center and customer knowledge sales.

  19. Identification of Achromobacter xylosoxidans by detection of the bla(OXA-114-like) gene intrinsic in this species.

    Science.gov (United States)

    Turton, Jane F; Mustafa, Nazim; Shah, Jayesh; Hampton, Catherine V; Pike, Rachel; Kenna, Dervla T

    2011-07-01

    Achromobacter xylosoxidans is an emerging pathogen among patients with cystic fibrosis. Here we describe a specific PCR for identification of this organism, based on detection of bla(OXA-114-like). Comparison of isolates by pulsed-field gel electrophoresis revealed evidence of cross-infection in some cases, but most patients harbored their own strain.

  20. Prospects of HTGR process heat application and role of HTTR

    International Nuclear Information System (INIS)

    At Japan Atomic Energy Research Institute, an effort on development of process heat application with high temperature gas cooled reactor (HTGR) has been continued for providing a future clean alternative to the burning of fossil energy for the production of industrial process heat. The project is named 'HTTR Heat Utilization Project', which includes a demonstration of hydrogen production using the first Japanese HTGR of High Temperature Engineering Test Reactor (HTTR). In the meantime, some countries, such as China, Indonesia, Russia and South Africa are trying to explore the HTGR process heat application for industrial use. One of the key issues for this application is economy. It has been recognized for a long time and still now that the HTGR heat application system is not economically competitive to the current fossil ones, because of the high cost of the HTGR itself. However, the recent movement on the HTGR development, as represented by South Africa Pebble Beds Modular Reactor (SA-PBMR) Project, has revealed that the HTGRs are well economically competitive in electricity production to fossil fuel energy supply under a certain condition. This suggests that the HTGR process heat application will also possibly get economical in the near future. In the present paper, following a brief introduction describing the necessity of the HTGRs for the future process heat application, Japanese activities and prospect of the development on the process heat application with the HTGRs are described in relation with the HTTR Project. In conclusion, the process heat application system with HTGRs is thought technically and economically to be one of the most promising applications to solve the global environmental issues and energy shortage which may happen in the future. However, the commercialization for the hydrogen production system from water, which is the final goal of the HTGR process heat application, must await the technology development to be completed in 2030's at the

  1. blaCTX-M-I group extended spectrum beta lactamase-producing Salmonella typhi from hospitalized patients in Lagos, Nigeria

    Directory of Open Access Journals (Sweden)

    Akinyemi KO

    2015-05-01

    Full Text Available Kabiru O Akinyemi,1 Bamidele A Iwalokun,2 Olajide O Alafe,1 Sulaiman A Mudashiru,1 Christopher Fakorede,11Department of Microbiology, Lagos State University, Ojo, Lagos, Nigeria; 2Biochemistry and Nutrition Division, Nigerian Institute of Medical Research, Yaba, Lagos, NigeriaPurpose: The global spread of blaCTX-M-I extended-spectrum beta-lactamase (ESBL-producing Salmonella spp. remains a major threat to treatment and control. Evidence of emergence and spread of this marker are lacking in Nigeria. This study investigated blaCTX-M-I ESBL production among Salmonella isolates from hospitalized patients.Methods: Patients (158 total made up of two groups were evaluated. Group A was composed of 135 patients with persistent pyrexia and group B was composed of 23 gastroenteritis patients and their stool samples. Samples were cultured, and isolates were identified and were subjected to antibiotic susceptibility testing by standard methods. Isolates were further screened for ESBL production, blaCTX-M-I genes and transferability by double disk synergy test, plasmid extraction, polymerase chain reaction, and conjugation experiment.Results: Thirty-five (25.9% Salmonella isolates were identified from group A, of which 74.3% were S. typhi, 22.9% were S. paratyphi and two (5.7% were invasive non-typhoidal S. enteritidis. Nine Plasmodium falciparum infections were recorded, four of which were identified as co-infections with typhoidal Salmonella. Only two (8.7% S. enteritidis samples were obtained from group B (P>0.05. A total of 24 isolates were ESBL-positive, eliciting resistance to five to seven antibiotics, and were multiple-drug resistant. ESBL production due to the blaCTX-M-I gene cluster was detected in eleven (45.8% Salmonella isolates. Nine (81.8% of the eleven blaCTX-M-I ESBL producers were S. typhi and two (18.2% isolates were S. enteritidis. Four of nine S. typhi blaCTX-M-I ESBL-producing strains harbored 23 kb self-transmissible plasmid that was co

  2. Evaluation of Select Surface Processing Techniques for In Situ Application During the Additive Manufacturing Build Process

    Science.gov (United States)

    Book, Todd A.; Sangid, Michael D.

    2016-07-01

    Although additive manufacturing offers numerous performance advantages for different applications, it is not being used for critical applications due to uncertainties in structural integrity as a result of innate process variability and defects. To minimize uncertainty, the current approach relies on the concurrent utilization of process monitoring, post-processing, and non-destructive inspection in addition to an extensive material qualification process. This paper examines an alternative approach by evaluating the application of select surface process techniques, to include sliding severe plastic deformation (SPD) and fine particle shot peening, on direct metal laser sintering-produced AlSi10Mg materials. Each surface processing technique is compared to baseline as-built and post-processed samples as a proof of concept for surface enhancement. Initial results pairing sliding SPD with the manufacture's recommended thermal stress relief cycle demonstrated uniform recrystallization of the microstructure, resulting in a more homogeneous distribution of strain among the microstructure than as-built or post-processed conditions. This result demonstrates the potential for the in situ application of various surface processing techniques during the layerwise direct metal laser sintering build process.

  3. Evaluation of Select Surface Processing Techniques for In Situ Application During the Additive Manufacturing Build Process

    Science.gov (United States)

    Book, Todd A.; Sangid, Michael D.

    2016-03-01

    Although additive manufacturing offers numerous performance advantages for different applications, it is not being used for critical applications due to uncertainties in structural integrity as a result of innate process variability and defects. To minimize uncertainty, the current approach relies on the concurrent utilization of process monitoring, post-processing, and non-destructive inspection in addition to an extensive material qualification process. This paper examines an alternative approach by evaluating the application of select surface process techniques, to include sliding severe plastic deformation (SPD) and fine particle shot peening, on direct metal laser sintering-produced AlSi10Mg materials. Each surface processing technique is compared to baseline as-built and post-processed samples as a proof of concept for surface enhancement. Initial results pairing sliding SPD with the manufacture's recommended thermal stress relief cycle demonstrated uniform recrystallization of the microstructure, resulting in a more homogeneous distribution of strain among the microstructure than as-built or post-processed conditions. This result demonstrates the potential for the in situ application of various surface processing techniques during the layerwise direct metal laser sintering build process.

  4. Applications of nuclear magnetic resonance imaging in process engineering

    Science.gov (United States)

    Gladden, Lynn F.; Alexander, Paul

    1996-03-01

    During the past decade, the application of nuclear magnetic resonance (NMR) imaging techniques to problems of relevance to the process industries has been identified. The particular strengths of NMR techniques are their ability to distinguish between different chemical species and to yield information simultaneously on the structure, concentration distribution and flow processes occurring within a given process unit. In this paper, examples of specific applications in the areas of materials and food processing, transport in reactors and two-phase flow are discussed. One specific study, that of the internal structure of a packed column, is considered in detail. This example is reported to illustrate the extent of new, quantitative information of generic importance to many processing operations that can be obtained using NMR imaging in combination with image analysis.

  5. Application of the geothermal energy in the industrial processes

    International Nuclear Information System (INIS)

    In the worldwide practice, the geothermal energy application, as an alternative energy resource, can be of great importance. This is especially case in the countries where exceptional natural geothermal potential exists. Despite using geothermal energy for both greenhouses heating and balneology, the one can be successfully implemented in the heat requiring industrial processes. This kind of use always provides greater annual heat loading factor, since the industrial processes are not seasonal (or not the greater part of them). The quality of the geothermal resources that are available in Europe, dictates the use within the low-temperature range technological processes. However, these processes are significantly engaged in different groups of processing industries. But, beside this fact the industrial application of geothermal energy is at the beginning in the Europe. (Original)

  6. Fluctuations of Lévy processes with applications introductory lectures

    CERN Document Server

    Kyprianou, Andreas E

    2014-01-01

    Lévy processes are the natural continuous-time analogue of random walks and form a rich class of stochastic processes around which a robust mathematical theory exists. Their application appears in the theory of many areas of classical and modern stochastic processes including storage models, renewal processes, insurance risk models, optimal stopping problems, mathematical finance, continuous-state branching processes and positive self-similar Markov processes. This textbook is based on a series of graduate courses concerning the theory and application of Lévy processes from the perspective of their path fluctuations. Central to the presentation is the decomposition of paths in terms of excursions from the running maximum as well as an understanding of short- and long-term behaviour. The book aims to be mathematically rigorous while still providing an intuitive feel for underlying principles. The results and applications often focus on the case of Lévy processes with jumps in only one direction, for which r...

  7. Agricultural and Food Processing Applications of Pulsed Power Technology

    Science.gov (United States)

    Takaki, Koichi; Ihara, Satoshi

    Recent progress of agricultural and food processing applications of pulsed power is described in this paper. Repetitively operated compact pulsed power generators with a moderate peak power have been developed for the agricultural and the food processing applications. These applications are mainly based on biological effects and can be categorized as decontamination of air and liquid, germination promotion, inhabitation of saprophytes growth, extraction of juice from fruits and vegetables, and fertilization of liquid medium, etc. Types of pulsed power that have biological effects are caused with gas discharges, water discharges, and electromagnetic fields. The discharges yield free radicals, UV radiation, intense electric field, and shock waves. Biologically based applications of pulsed power are performed by selecting the type that gives the target objects the adequate result from among these agents or byproducts. For instance, intense electric fields form pores on the cell membrane, which is called electroporation, or influence the nuclei.

  8. 3rd Workshop on Branching Processes and their Applications

    CERN Document Server

    González, Miguel; Gutiérrez, Cristina; Martínez, Rodrigo; Minuesa, Carmen; Molina, Manuel; Mota, Manuel; Ramos, Alfonso; WBPA15

    2016-01-01

    This volume gathers papers originally presented at the 3rd Workshop on Branching Processes and their Applications (WBPA15), which was held from 7 to 10 April 2015 in Badajoz, Spain (http://branching.unex.es/wbpa15/index.htm). The papers address a broad range of theoretical and practical aspects of branching process theory. Further, they amply demonstrate that the theoretical research in this area remains vital and topical, as well as the relevance of branching concepts in the development of theoretical approaches to solving new problems in applied fields such as Epidemiology, Biology, Genetics, and, of course, Population Dynamics. The topics covered can broadly be classified into the following areas: 1. Coalescent Branching Processes 2. Branching Random Walks 3. Population Growth Models in Varying and Random Environments 4. Size/Density/Resource-Dependent Branching Models 5. Age-Dependent Branching Models 6. Special Branching Models 7. Applications in Epidemiology 8. Applications in Biology and Genetics Offer...

  9. Radiation Processed Materials in Products from Polymers for Agricultural Applications

    International Nuclear Information System (INIS)

    This publication results from a technical meeting on radiation processed materials in products from polymers for agricultural applications, which was held from 8 to 12 July 2013 at the IAEA in Vienna. The meeting provided a forum for the sharing of practical experiences and lessons learned, and reviewed the recent developments in the use of radiation technologies for the preparation of environmental friendly products based on polymers for agricultural applications

  10. Processing, properties and some novel applications of magnetic nanoparticles

    Indian Academy of Sciences (India)

    D Bahadur; J Giri; Bibhuti B Nayak; T Sriharsha; P Pradhan; N K Prasad; K C Barick; R D Ambashta

    2005-10-01

    Magnetic nanoparticles have been prepared by various soft chemical methods including self-assembly. The bare or surface-modified particles find applications in areas such as hyperthermia treatment of cancer and magnetic field-assisted radioactive chemical separation. We present here some of the salient features of processing of nanostructured magnetic materials of different sizes and shapes, their properties and some possible applications. The materials studied included metals, metal-ceramic composites, and ferrites.

  11. Study on customization process and application via Internet

    Institute of Scientific and Technical Information of China (English)

    周康渠; YANG; Yu; 等

    2002-01-01

    Networked customization is an important way for enterprises to satisfy customers'individual requirements.From this point of view,the study on networked customization process and application is started with analyzing the customization process in detail,in which the customization process is divided into 6 stages including information capture,need submission,need affirmation,need interaction,creating customization orders and customization production.A general customization process chart for common products is presented,which describes the communication between customers and enterprises in the entire customization process.The method of analyzing customization process is pressented.The product customization subsystem in the system of ceramic product marketing and customization of Chongqing CHN & CHN Ceramics Co.Ltd.is introduced to explicate the process of customization via Internet.

  12. Multiresolution approach to processing images for different applications interaction of lower processing with higher vision

    CERN Document Server

    Vujović, Igor

    2015-01-01

    This book presents theoretical and practical aspects of the interaction between low and high level image processing. Multiresolution analysis owes its popularity mostly to wavelets and is widely used in a variety of applications. Low level image processing is important for the performance of many high level applications. The book includes examples from different research fields, i.e. video surveillance; biomedical applications (EMG and X-ray); improved communication, namely teleoperation, telemedicine, animation, augmented/virtual reality and robot vision; monitoring of the condition of ship systems and image quality control.

  13. Potential Applications of Zeolite Membranes in Reaction Coupling Separation Processes

    Directory of Open Access Journals (Sweden)

    Tunde V. Ojumu

    2012-10-01

    Full Text Available Future production of chemicals (e.g., fine and specialty chemicals in industry is faced with the challenge of limited material and energy resources. However, process intensification might play a significant role in alleviating this problem. A vision of process intensification through multifunctional reactors has stimulated research on membrane-based reactive separation processes, in which membrane separation and catalytic reaction occur simultaneously in one unit. These processes are rather attractive applications because they are potentially compact, less capital intensive, and have lower processing costs than traditional processes. Therefore this review discusses the progress and potential applications that have occurred in the field of zeolite membrane reactors during the last few years. The aim of this article is to update researchers in the field of process intensification and also provoke their thoughts on further research efforts to explore and exploit the potential applications of zeolite membrane reactors in industry. Further evaluation of this technology for industrial acceptability is essential in this regard. Therefore, studies such as techno-economical feasibility, optimization and scale-up are of the utmost importance.

  14. Hidden Markov processes theory and applications to biology

    CERN Document Server

    Vidyasagar, M

    2014-01-01

    This book explores important aspects of Markov and hidden Markov processes and the applications of these ideas to various problems in computational biology. The book starts from first principles, so that no previous knowledge of probability is necessary. However, the work is rigorous and mathematical, making it useful to engineers and mathematicians, even those not interested in biological applications. A range of exercises is provided, including drills to familiarize the reader with concepts and more advanced problems that require deep thinking about the theory. Biological applications are t

  15. Image and signal processing for networked eHealth applications

    CERN Document Server

    Maglogiannis, Ilias

    2006-01-01

    E-health is closely related with networks and telecommunications when dealing with applications of collecting or transferring medical data from distant locations for performing remote medical collaborations and diagnosis. In this book we provide an overview of the fields of image and signal processing for networked and distributed e-health applications and their supporting technologies. The book is structured in 10 chapters, starting the discussion from the lower end, that of acquisition and processing of biosignals and medical images and ending in complex virtual reality systems and technique

  16. Text mining from ontology learning to automated text processing applications

    CERN Document Server

    Biemann, Chris

    2014-01-01

    This book comprises a set of articles that specify the methodology of text mining, describe the creation of lexical resources in the framework of text mining and use text mining for various tasks in natural language processing (NLP). The analysis of large amounts of textual data is a prerequisite to build lexical resources such as dictionaries and ontologies and also has direct applications in automated text processing in fields such as history, healthcare and mobile applications, just to name a few. This volume gives an update in terms of the recent gains in text mining methods and reflects

  17. THE WAY OF PROCESSING DATA IN APPROACHING ECONOMIC APPLICATIONS

    Directory of Open Access Journals (Sweden)

    ADRIAN GHENCEA

    2012-05-01

    Full Text Available Economic Informatics originates in the industry economy and the electronic processing of information. A clear distinction is made between IT and economic informatics, and further between general and particular economic informatics (the particular economic informatics meaning administration, industrial informatics etc. Economic informatics is deemed to be an applicative science relating to the conception, working modality and representation of IT and communication systems, oriented towards companies which are using electronic computers. This paper pursues to integrate applications allowing the information systems to interconnect at informational level, by information sharing, and at service level, considering the control of the related processes in real time.

  18. Image processing and mathematical morphology fundamentals and applications

    CERN Document Server

    Shih, Frank Y

    2009-01-01

    In the development of digital multimedia, the importance and impact of image processing and mathematical morphology are well documented in areas ranging from automated vision detection and inspection to object recognition, image analysis and pattern recognition. Those working in these ever-evolving fields require a solid grasp of basic fundamentals, theory, and related applications and few books can provide the unique tools for learning contained in this text. Image Processing and Mathematical Morphology: Fundamentals and Applications is a comprehensive, wide-ranging overview of morphological

  19. High-flux solar photon processes: Opportunities for applications

    Energy Technology Data Exchange (ETDEWEB)

    Steinfeld, J I; Coy, S L; Herzog, H; Shorter, J A; Schlamp, M; Tester, J W; Peters, W A [Massachusetts Inst. of Tech., Cambridge, MA (United States)

    1992-06-01

    The overall goal of this study was to identify new high-flux solar photon (HFSP) processes that show promise of being feasible and in the national interest. Electric power generation and hazardous waste destruction were excluded from this study at sponsor request. Our overall conclusion is that there is promise for new applications of concentrated solar photons, especially in certain aspects of materials processing and premium materials synthesis. Evaluation of the full potential of these and other possible applications, including opportunities for commercialization, requires further research and testing. 100 refs.

  20. Applications of evolutionary computation in image processing and pattern recognition

    CERN Document Server

    Cuevas, Erik; Perez-Cisneros, Marco

    2016-01-01

    This book presents the use of efficient Evolutionary Computation (EC) algorithms for solving diverse real-world image processing and pattern recognition problems. It provides an overview of the different aspects of evolutionary methods in order to enable the reader in reaching a global understanding of the field and, in conducting studies on specific evolutionary techniques that are related to applications in image processing and pattern recognition. It explains the basic ideas of the proposed applications in a way that can also be understood by readers outside of the field. Image processing and pattern recognition practitioners who are not evolutionary computation researchers will appreciate the discussed techniques beyond simple theoretical tools since they have been adapted to solve significant problems that commonly arise on such areas. On the other hand, members of the evolutionary computation community can learn the way in which image processing and pattern recognition problems can be translated into an...

  1. APPLICATION OF INDICATORS BUSINESS PROCESSES FOR ENTERPRISE MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Yakhontova I. M.

    2015-11-01

    Full Text Available The formation of a system of indicators for assessing the performance of the business processes of the enterprise is one of the most actual and modern directions of increase of efficiency of activity of the enterprise. The system of indicators should be developed in accordance with the specifics of company's activity, its strategic goals and available resources. Consideration of the process of developing a system of indicators of business processes on a specific example of an industrial enterprise allows not only to evaluate the operation of departments in terms of running processes, but also to develop a list of measures to improve the efficiency of functions execution of business processes. The work presents theoretical information, the development of a system of indicators of business processes within the selected areas using this method of process optimization. The initial stage of the work on the development and evaluation of a system of indicators of business processes was made by enterprise characteristics, description of its organizational structure and core activities. The article considers the indicators of process, product and satisfaction of customers in terms of cost, time and technical performance. For example, the business process that best reflects the specifics of the enterprise, the process of developing a system of indicators and presented conclusions, and developed recommendations and actions for the application of the system of indicators of business processes

  2. Process Development of Porcelain Ceramic Material with Binder Jetting Process for Dental Applications

    Science.gov (United States)

    Miyanaji, Hadi; Zhang, Shanshan; Lassell, Austin; Zandinejad, Amirali; Yang, Li

    2016-03-01

    Custom ceramic structures possess significant potentials in many applications such as dentistry and aerospace where extreme environments are present. Specifically, highly customized geometries with adequate performance are needed for various dental prostheses applications. This paper demonstrates the development of process and post-process parameters for a dental porcelain ceramic material using binder jetting additive manufacturing (AM). Various process parameters such as binder amount, drying power level, drying time and powder spread speed were studied experimentally for their effect on geometrical and mechanical characteristics of green parts. In addition, the effects of sintering and printing parameters on the qualities of the densified ceramic structures were also investigated experimentally. The results provide insights into the process-property relationships for the binder jetting AM process, and some of the challenges of the process that need to be further characterized for the successful adoption of the binder jetting technology in high quality ceramic fabrications are discussed.

  3. Probability and Random Processes With Applications to Signal Processing and Communications

    CERN Document Server

    Miller, Scott

    2012-01-01

    Miller and Childers have focused on creating a clear presentation of foundational concepts with specific applications to signal processing and communications, clearly the two areas of most interest to students and instructors in this course. It is aimed at graduate students as well as practicing engineers, and includes unique chapters on narrowband random processes and simulation techniques. The appendices provide a refresher in such areas as linear algebra, set theory, random variables, and more. Probability and Random Processes also includes applications in digital communications, informati

  4. High Throughput Multispectral Image Processing with Applications in Food Science

    OpenAIRE

    Tsakanikas, Panagiotis; Pavlidis, Dimitris; Nychas, George-John

    2015-01-01

    Recently, machine vision is gaining attention in food science as well as in food industry concerning food quality assessment and monitoring. Into the framework of implementation of Process Analytical Technology (PAT) in the food industry, image processing can be used not only in estimation and even prediction of food quality but also in detection of adulteration. Towards these applications on food science, we present here a novel methodology for automated image analysis of several kinds of fo...

  5. Benchmarking Distributed Stream Processing Platforms for IoT Applications

    OpenAIRE

    Shukla, Anshu; Simmhan, Yogesh

    2016-01-01

    Internet of Things (IoT) is a technology paradigm where millions of sensors monitor, and help inform or manage, physical, envi- ronmental and human systems in real-time. The inherent closed-loop re- sponsiveness and decision making of IoT applications makes them ideal candidates for using low latency and scalable stream processing plat- forms. Distributed Stream Processing Systems (DSPS) are becoming es- sential components of any IoT stack, but the efficacy and performance of contemporary DSP...

  6. Processing & Learning in Multiple Modalities: Applications for AAC

    OpenAIRE

    Loncke, Filip; Hilton, Jane; Weng, Pei-Lin; Corthals, Paul; El Fallah, Marwane; Leconte, Claire

    2009-01-01

    Most AAC applications use multiple representations of concepts; orthographic, pictographic, auditory, and gestural information are often combined. The underlying hypothesis is that multimodality facilitates learning and processing. Clinicians want to use multimodality in strategic way to increase learning and speed of processing. This presentation will discuss the results of two coordinated studies in two countries (the United States and France) in which learning curves of modality-related le...

  7. Particularities of Verification Processes for Distributed Informatics Applications

    Directory of Open Access Journals (Sweden)

    Ion IVAN

    2013-01-01

    Full Text Available This paper presents distributed informatics applications and characteristics of their development cycle. It defines the concept of verification and there are identified the differences from software testing. Particularities of the software testing and software verification processes are described. The verification steps and necessary conditions are presented and there are established influence factors of quality verification. Software optimality verification is analyzed and some metrics are defined for the verification process.

  8. Application of electrical capacitance tomography for imaging industrial processes

    Institute of Scientific and Technical Information of China (English)

    DYAKOWSKI Tom

    2005-01-01

    Electrical tomography is, in certain cases, the most attractive method for real imaging of industrial processes, because of its inherent simplicity, rugged cons truction of the tomographer and high-speed capability. This paper presents examples illustrating applications of electrical tomography for imaging fluidized beds, bubble columns and pneumatic conveyors. Electrical tomography opens up new ways for processing, imaging and modelling multi-phase flows as shown by 2D and 3D images illustrating the various types of flow morphology.

  9. APPLICATION OF MVP IN REAL-TIME IMAGE PROCESSING

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    MVP is a digital signal processor, which is of MIMD structure and fit for multimedia application. MVP has several processors in it, and its operation is characteristic of parallelism and pipeline; therefore, real-time signal processing can be done on it. This paper presents the image processing system based on MVP, explains the principles of parallel task assignment and hardware pipeline design, and gives out the example of target tracking and edge detection.

  10. Application of pulse combustion technology in spray drying process

    OpenAIRE

    I. Zbicinski; I. Smucerowicz; C. Strumillo; Crowe, C

    2000-01-01

    The paper presents development of valved pulse combustor designed for application in drying process and drying tests performed in a specially built installation. Laser technique was applied to investigate the flow field and structure of dispersed phase during pulse combustion spray drying process. PDA technique was used to determine initial atomization parameters as well as particle size distribution, velocity of the particles, mass concentration of liquid phase in the cross section of spray ...

  11. Chromosomal blaCTX-M-₁₅ associated with ISEcp1 in Proteus mirabilis and Morganella morganii isolated at the Military Hospital of Tunis, Tunisia.

    Science.gov (United States)

    Mahrouki, Sihem; Belhadj, Omrane; Chihi, Hela; Mohamed, Ben Moussa; Celenza, Giuseppe; Amicosante, Gianfranco; Perilli, Mariagrazia

    2012-09-01

    This study investigated the genetic environment of bla(CTX-M) genes and associated resistance genes in seven Proteus mirabilis and six Morganella morganii extended spectrum β-lactamase (ESBL)-positive isolates. The isolates were recovered from hospitalized patients with respiratory or urinary tract infections at the Military Hospital of Tunis, Tunisia. Twenty-one of the 200 strains exhibited non-susceptibility to third generation cephalosporins and, among these strains, the double-disk synergy test confirmed the ESBL phenotype in 13 isolates. These ESBL producers were co-resistant to chloramphenicol, tetracycline and oflaxacin but remained susceptible to ertapenem (MIC<0.25 mg l(-1)). The presence and nature of bla(CTX-M-15), bla(CTX-M-8), bla(TEM-24), bla(TEM-1) and bla(TEM-2) genes was determined by PCR and sequencing. Chromosomal localization of the bla(CTX-M-15) gene was confirmed in all strains, with the exception of M. morganii isolate M-17991, by Southern-blot analysis performed either on chromosomal or plasmid DNA. M. morganii M-12012 and M. morganii M-6019 showed the same PFGE pattern, whereas the remaining CTX-M-15-producing isolates were unrelated. The presence of ISEcp1 was ascertained in CTX-M-15-producing isolates. A class 1 integron with different gene cassettes (dfrA1, orfC and aadB) was found in five P. mirabilis and six M. morganii isolates.

  12. First Description of the Extended Spectrum-Beta-Lactamase Gene blaCTX-M-109 in Salmonella Grumpensis Strains Isolated from Neonatal Nosocomial Infections in Dakar, Senegal.

    Directory of Open Access Journals (Sweden)

    Amadou Diop

    Full Text Available Nosocomial infections are very common in African hospitals, particularly in neonatal units. These infections are most often caused by bacteria such as Escherichia coli, Klebsiella spp and Staphylococcus spp. Salmonella strains are rarely involved in nosocomial infections. Here, we report the first description of S. Grumpensis in neonatal infections in Senegal. Seventeen Salmonella strains were isolated from hospitalized infants' stool samples. The following resistance phenotype was described in strains: AMXRTICRCFR FOXRCFXRCTXRCAZRIMPSATMRNARNORRCIPRTMRGMRTERSXTR. All isolates were susceptible to imipenem, 15 out of 17 produced an extended spectrum ß-lactamase (ESBL. blaOXA-1, blaSHV-1, blaTEM-1, blaCTX-M1 genes were detected in strains 8, 13, 5 and 8, respectively. blaCTX-M1 sequencing revealed the presence of blaCTX-M-109. Thirteen of the 17 Salmonella Grumpensis strains were analyzed by PFGE. These 13 isolates belonged to a single pulsotype and were genotypically identical. This is the first report of neonatal S. Grumpensis infections in Senegal, and the first report of blaCTX-M-109 in the genus Salmonella.

  13. Mathematical Models of Visual Information Processing in the Human Brain and Applications to Image Processing

    OpenAIRE

    Arai, Hitoshi

    2013-01-01

    In this lecture I give a survey of joint works of Hitoshi Arai and Shinobu Arai. The main purpose of our study is to construct mathematical models of visual information processing in the brain, and to give applications to image processing. On the past few decades, several studies have been made on mathematical models of visual information processing in the human brain. Our new models are constructed by using simple pinwheel framelets ([4]) and pinwheel framelets ([6]), which are a new class o...

  14. Fractional Order Signal Processing Introductory Concepts and Applications

    CERN Document Server

    Das, Saptarshi

    2012-01-01

    The book tries to briefly introduce the diverse literatures in the field of fractional order signal processing which is becoming an emerging topic among an interdisciplinary community of researchers. This book is aimed at postgraduate and beginning level research scholars who would like to work in the field of Fractional Order Signal processing (FOSP). The readers should have preliminary knowledge about basic signal processing techniques. Prerequisite knowledge of fractional calculus is not essential and is exposited at relevant places in connection to the appropriate signal processing topics. Basic signal processing techniques like filtering, estimation, system identification, etc. in the light of fractional order calculus are presented along with relevant application areas. The readers can easily extend these concepts to varied disciplines like image or speech processing, pattern recognition, time series forecasting, financial data analysis and modeling, traffic modeling in communication channels, optics, b...

  15. New Insulation Application Process for Wind-And Magnet Fabrication

    Science.gov (United States)

    Kano, K. S.; Stewart, M. W.; Hooker, M. W.

    2008-03-01

    Wind-and-react processes offer a cost-effective means of fabricating large-scale Nb3Sn magnets, while also eliminating the need to manipulate the brittle superconductor after the high-temperature reaction process. Composite Technology Development, Inc. (CTD) has developed a hybrid inorganic/organic insulation system that can be co-processed with the Nb3Sn magnet at elevated temperatures. In this work, a new process was demonstrated for applying a thin, ceramic-based insulation that is compatible with wind-and-react processing. The insulation was applied to Rutherford cables using a continuous manufacturing process, and cable assemblies (i.e., 10-stacks) were fabricated and tested. The results of this work show that the insulation possesses a high strain tolerance, as well as the dielectric strength and fatigue resistance needed for high-field magnet applications.

  16. Application of digital image processing for pot plant grading.

    NARCIS (Netherlands)

    Dijkstra, J.

    1994-01-01

    The application of digital image processing for grading of pot plants has been studied. Different techniques e.q. plant part identification based on knowledge based segmentation, have been developed to measure features of plants in different growth stage. Growth experiments were performed to identif

  17. Ion exchange membranes in seawater applications : processes and characteristics

    NARCIS (Netherlands)

    Galama, A.H.

    2015-01-01

    Officiële titel ENG: Ion exchange membranes in seawater applications. Processes and characteristics Officiële titel NL: Ionwisselende membranen in zeewatertoepassingen. Processen en eigenschappen Auteur: A.H.Galama Jaar: 2015 ISBN: 978-94-6257-225-6 Samenvatting Zeewaterontzouting stelt me

  18. Computer and control applications in a vegetable processing plant

    Science.gov (United States)

    There are many advantages to the use of computers and control in food industry. Software in the food industry takes 2 forms - general purpose commercial computer software and software for specialized applications, such as drying and thermal processing of foods. Many applied simulation models for d...

  19. 10 CFR 451.9 - Procedures for processing applications.

    Science.gov (United States)

    2010-01-01

    ... or operators of qualified renewable energy facilities using solar, wind, ocean, geothermal, and... 10 Energy 3 2010-01-01 2010-01-01 false Procedures for processing applications. 451.9 Section 451.9 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION RENEWABLE ENERGY PRODUCTION INCENTIVES §...

  20. 44 CFR 209.8 - Application and review process.

    Science.gov (United States)

    2010-10-01

    ... processing subgrants to applicants in accordance with 44 CFR part 13 and this part. (b) Timeframes. We will... historic preservation that is readily available; (9) Attachments for each property as follows: (i) A... list (provide NFIP Repetitive Loss Property Locator Number, if available); and (xiii) Observations...

  1. Application of an image processing software for quantitative autoradiography

    International Nuclear Information System (INIS)

    The present communication deals with the utilization of an image processing device for quantitative whole-body autoradiography, cell counting and also for interpretation of chromatograms. It is shown that the system parameters allow an adequate and precise determination of optical density values. Also shown are the main error sources limiting the applicability of the system. (orig.)

  2. Elements of the theory of Markov processes and their applications

    CERN Document Server

    Bharucha-Reid, A T

    2010-01-01

    This graduate-level text and reference in probability, with numerous applications to several fields of science, presents nonmeasure-theoretic introduction to theory of Markov processes. The work also covers mathematical models based on the theory, employed in various applied fields. Prerequisites are a knowledge of elementary probability theory, mathematical statistics, and analysis. Appendixes. Bibliographies. 1960 edition.

  3. Application of Resid Hydrogenation Process in Mainland China

    Institute of Scientific and Technical Information of China (English)

    Diao Wangsheng

    2007-01-01

    This article mainly refers to a brief introduction on the design and operation of resid hydrogenation units in Mainland China in order to keep the peers abreast of the basic status of application of resid hydrogenation process in the Mainland China.

  4. Applications Of Laser Processing For Automotive Manufacturing In Japan

    Science.gov (United States)

    Ito, Masashi; Ueda, Katsuhiko; Takagi, Soya

    1986-11-01

    Recently in Japan, laser processing is increasingly being employed for production, so that laser cutting, laser welding and other laser material processing have begun to be used in various industries. As a result, the number of lasers sold has been increasing year by year in Japan. In the Japanese automotive industry, a number applications have been introduced in laboratories and production lines. In this paper, several current instances of such laser applications will be introduced. In the case of welding, studies have been conducted on applying laser welding to automatic transmission components, in place of electron beam welding. Another example of application, the combination of lasers and robots to form highly flexible manufacturing systems, has been adopted for trimming steel panel and plastic components.

  5. Application of Laser Ablation Processing in Electric Power System Industries

    Science.gov (United States)

    Konagai, Chikara; Sano, Yuji; Nittoh, Koichi; Kuwako, Akira

    The present status of laser ablation processing applied in electric power system industries is reviewed. High average power LD-pumped Nd:YAG lasers with Q-switch have been developed and currently introduced into various applications. Optical fiber based laser beam delivery systems for Q-switched pulse laser are also being developed these years. Based on such laser and beam delivery technology, laser ablation processes are gradually introduced in maintenance of nuclear power plant, thermal power plant and electrical power distribution system. Cost effectiveness, robustness and reliability of the process is highly required for wide utilization in these fields.

  6. Improved Strategies for Parallel Medical Image Processing Applications

    Institute of Scientific and Technical Information of China (English)

    WANG Kun; WANG Xiao-ying; LI San-li; CHEN Ying

    2008-01-01

    In order to meet the demands of high efficient and real-time computer assisted diagnosis as well as screening in medical area, to improve the efficacy of parallel medical image processing is of great importance. This article proposes improved strategies for parallel medical image processing applications,which is categorized into two genera. For each genus individual strategy is devised, including the theoretic algorithm for minimizing the exertion time. Experiment using mammograms not only justifies the validity of the theoretic analysis, with reasonable difference between the theoretic and measured value, but also shows that when adopting the improved strategies, efficacy of medical image parallel processing is improved greatly.

  7. Distance transformations: fast algorithms and applications to medical image processing

    OpenAIRE

    Cuisenaire, O.

    1999-01-01

    Medical image processing is a demanding domain, both in terms of CPU and memory requirements. The volume of data to be processed is often large (a typical MRI dataset requires 10 MBytes) and many processing tools are only useful to the physician if they are available as real-time applications, i.e. if they run in a few seconds at most. Of course, a large part of these demands are - and will be - handled by the development of more powerful hardware. On the other hand, when faced with non-linea...

  8. An introduction to stochastic processes with applications to biology

    CERN Document Server

    Allen, Linda J S

    2010-01-01

    An Introduction to Stochastic Processes with Applications to Biology, Second Edition presents the basic theory of stochastic processes necessary in understanding and applying stochastic methods to biological problems in areas such as population growth and extinction, drug kinetics, two-species competition and predation, the spread of epidemics, and the genetics of inbreeding. Because of their rich structure, the text focuses on discrete and continuous time Markov chains and continuous time and state Markov processes.New to the Second EditionA new chapter on stochastic differential equations th

  9. Beta-lactam induction of ISEcp1B-mediated mobilization of the naturally occurring bla(CTX-M) beta-lactamase gene of Kluyvera ascorbata

    OpenAIRE

    Nordmann, Patrice; Lartigue, Marie-Frédérique; Poirel, Laurent

    2008-01-01

    ISEcp1B is an insertion element associated with the emerging expanded-spectrum β-lactamase blaCTX-M genes in Enterobacteriaceae. Because ISEcp1B-blaCTX-M positive strains may be identified from humans and animals, the ability of this insertion sequence to mobilize the blaCTX-M-2 gene was tested from its progenitor Kluyvera ascorbata to study the effects of amoxicillin/clavulanic and cefquinome as enhancers of transposition. These β-lactam molecules are administered parenterally to treat infec...

  10. Beta-lactam induction of ISEcp1B-mediated mobilization of the naturally occurring bla(CTX-M) beta-lactamase gene of Kluyvera ascorbata.

    OpenAIRE

    Nordmann, Patrice; Lartigue, Marie-Frédérique; Poirel, Laurent

    2008-01-01

    ISEcp1B is an insertion element associated with the emerging expanded-spectrum beta-lactamase bla(CTX-M) genes in Enterobacteriaceae. Because ISEcp1B-bla(CTX-M)positive strains may be identified from humans and animals, the ability of this insertion sequence to mobilize the bla(CTX-M-2) gene was tested from its progenitor Kluyvera ascorbata to study the effects of amoxicillin/clavulanic and cefquinome as enhancers of transposition. These beta-lactam molecules are administered parenterally to ...

  11. Double Copies of bla(KPC-3)::Tn4401a on an IncX3 Plasmid in Klebsiella pneumoniae Successful Clone ST512 from Italy.

    Science.gov (United States)

    Fortini, Daniela; Villa, Laura; Feudi, Claudia; Pires, João; Bonura, Celestino; Mammina, Caterina; Endimiani, Andrea; Carattoli, Alessandra

    2016-01-01

    A carbapenem-resistant sequence type 512 (ST512) Klebsiella pneumoniae carbapenemase 3 (KPC-3)-producing K. pneumoniae strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014. ST512 is a worldwide successful clone associated with the spread of bla(KPC) genes located on the IncFIIk pKpQIL plasmid. In our ST512 strain, the bla(KPC-3) gene was unusually located on an IncX3 plasmid, whose complete sequence was determined. Two copies of bla(KPC-3)::Tn4401a caused by intramolecular transposition events were detected in the plasmid. PMID:26525794

  12. Applications of Process Synthesis: Moving from Conventional Chemical Processes towards Biorefinery Processes

    DEFF Research Database (Denmark)

    Yuan, Zhihong; Chen, Bingzhen; Gani, Rafiqul

    2013-01-01

    Concerns about diminishing petroleum reserves, enhanced worldwide demand for fuels and fluctuations in the global oil market, together with climate change and national security have promoted many initiatives for exploring alternative, non-petroleum based processes. Among these initiatives...... be predicted to play a significant role in the design and commercialization of sustainable and cost-effective biorefinery processes. The main objective of this perspective paper is to elucidate the potential opportunities that biorenewables processing offers to optimal synthesis; challenges and future...

  13. [Genetic Investigation of bla(CTX-M)-typing in Extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae from Clinical Specimens and Commercially Available Chicken Liver].

    Science.gov (United States)

    Kan, Miki; Shinomiya, Hiroto; Kitao, Takashi

    2016-05-01

    A genetic investigation consisting of the bla(CTX-M) typing was performed using 40 extended spectrum β-lactamase (ESBL)-producing Escherichia coli isolates from chicken liver and 43 ESBL-producing E. coli and 42 ESBL-producing Klebsiella pneumoniae isolates from patients. The types were determined using a sequence analysis. In 31 isolates in the bla(CTX-M-1) group, there were 13 with the bla(CTX-M-1) and all were from chicken liver. Nine E. coli isolates from chicken liver and one E. coli isolate from patients were found to be bla(CTX-M-55). In the bla(CTX-M-15), there were 6 E. coli isolates and one K. pneumoniae isolate from patients. All 39 isolates in the bla(CTX-M-2) group had the blac(CTX-M-2). Fifty-five isolates were found in the bla(CTX-M-9) group, the highest detection frequency, with 36 possessing bla(CTX-M-14) : 20 E. coli and 13 K. pneumoniae from patients and 3 E. coli from chicken liver. There were 17 bla(CTX-M-27) isolates, including 10 E. coli and 7 K. pneumoniae from patients. One bla(CTX-M-90) K. pneumoniae isolate and one bla(CTX-M-9) E. coli isolate were also obtained from patients. These results indicate that the E. coli isolates from chicken liver consist of bla(CTX-M-1), bla(CTX-M-2) and bla(CTX-M-55) ; the E. coli isolates from patients consist of bla(CTX-M-14) and bla(CTX-M-27) ; and the K. pneumoniae isolates from patients consist of bla(CTX-M-2), bla(CTX-M-14) and bla(CTX-M-27). Therefore, the bla(CTX-M) type differs in isolates from chicken liver and those from humans. These results suggest that it is unlikely that ESBL-producing E. coli from chicken liver are firmly established in the human intestinal tract.

  14. [Genetic Investigation of bla(CTX-M)-typing in Extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae from Clinical Specimens and Commercially Available Chicken Liver].

    Science.gov (United States)

    Kan, Miki; Shinomiya, Hiroto; Kitao, Takashi

    2016-05-01

    A genetic investigation consisting of the bla(CTX-M) typing was performed using 40 extended spectrum β-lactamase (ESBL)-producing Escherichia coli isolates from chicken liver and 43 ESBL-producing E. coli and 42 ESBL-producing Klebsiella pneumoniae isolates from patients. The types were determined using a sequence analysis. In 31 isolates in the bla(CTX-M-1) group, there were 13 with the bla(CTX-M-1) and all were from chicken liver. Nine E. coli isolates from chicken liver and one E. coli isolate from patients were found to be bla(CTX-M-55). In the bla(CTX-M-15), there were 6 E. coli isolates and one K. pneumoniae isolate from patients. All 39 isolates in the bla(CTX-M-2) group had the blac(CTX-M-2). Fifty-five isolates were found in the bla(CTX-M-9) group, the highest detection frequency, with 36 possessing bla(CTX-M-14) : 20 E. coli and 13 K. pneumoniae from patients and 3 E. coli from chicken liver. There were 17 bla(CTX-M-27) isolates, including 10 E. coli and 7 K. pneumoniae from patients. One bla(CTX-M-90) K. pneumoniae isolate and one bla(CTX-M-9) E. coli isolate were also obtained from patients. These results indicate that the E. coli isolates from chicken liver consist of bla(CTX-M-1), bla(CTX-M-2) and bla(CTX-M-55) ; the E. coli isolates from patients consist of bla(CTX-M-14) and bla(CTX-M-27) ; and the K. pneumoniae isolates from patients consist of bla(CTX-M-2), bla(CTX-M-14) and bla(CTX-M-27). Therefore, the bla(CTX-M) type differs in isolates from chicken liver and those from humans. These results suggest that it is unlikely that ESBL-producing E. coli from chicken liver are firmly established in the human intestinal tract. PMID:27529965

  15. IncA/C Plasmid Carrying bla(NDM-1), bla(CMY-16), and fosA3 in a Salmonella enterica Serovar Corvallis Strain Isolated from a Migratory Wild Bird in Germany.

    Science.gov (United States)

    Villa, L; Guerra, B; Schmoger, S; Fischer, J; Helmuth, R; Zong, Z; García-Fernández, A; Carattoli, A

    2015-10-01

    A Salmonella enterica serovar Corvallis strain was isolated from a wild bird in Germany. This strain carried the IncA/C2 pRH-1238 plasmid. Complete sequencing of the plasmid was performed, identifying the blaNDM-1, blaCMY-16, fosA3, sul1, sul2, strA, strB, aac(6')-Ib, aadA5, aphA6, tetA(A), mphA, floR, dfrA7, and merA genes, which confer clinically relevant resistance to most of the antimicrobial classes, including β-lactams with carbapenems, fosfomycin, aminoglycosides, co-trimoxazole, tetracyclines, and macrolides. The strain likely originated from the Asiatic region and was transferred to Germany through the Milvus migrans migratory route. PMID:26169417

  16. [Sustainable process improvement with application of 'lean philosophy'].

    Science.gov (United States)

    Rouppe van der Voort, Marc B V; van Merode, G G Frits; Veraart, Henricus G N

    2013-01-01

    Process improvement is increasingly being implemented, particularly with the aid of 'lean philosophy'. This management philosophy aims to improve quality by reducing 'wastage'. Local improvements can produce negative effects elsewhere due to interdependence of processes. An 'integrated system approach' is required to prevent this. Some hospitals claim that this has been successful. Research into process improvement with the application of lean philosophy has reported many positive effects, defined as improved safety, quality and efficiency. Due to methodological shortcomings and lack of rigorous evaluations it is, however, not yet possible to determine the impact of this approach. It is, however, obvious that the investigated applications are fragmentary, with a dominant focus on the instrumental aspect of the philosophy and a lack of integration in a total system, and with insufficient attention to human aspects. Process improvement is required to achieve better and more goal-oriented healthcare. To achieve this, hospitals must develop integrated system approaches that combine methods for process design with continuous improvement of processes and with personnel management. It is crucial that doctors take the initiative to guide and improve processes in an integral manner.

  17. Property Modelling for Applications in Chemical Product and Process Design

    DEFF Research Database (Denmark)

    Gani, Rafiqul

    is missing, the atom connectivity based model is employed to predict the missing group interaction. In this way, a wide application range of the property modeling tool is ensured. Based on the property models, targeted computer-aided techniques have been developed for design and analysis of organic chemicals......, polymers, mixtures as well as separation processes. The presentation will highlight the framework (ICAS software) for property modeling, the property models and issues such as prediction accuracy, flexibility, maintenance and updating of the database. Also, application issues related to the use of property......Physical-chemical properties of pure chemicals and their mixtures play an important role in the design of chemicals based products and the processes that manufacture them. Although, the use of experimental data in design and analysis of chemicals based products and their processes is desirable...

  18. Review of geographic processing techniques applicable to regional analysis

    Energy Technology Data Exchange (ETDEWEB)

    Durfee, R.C.

    1988-02-01

    Since the early 1970s regional environmental studies have been carried out at the Oak Ridge National Laboratory using computer-assisted techniques. This paper presents an overview of some of these past experiences and the capabilities developed at the Laboratory for processing, analyzing, and displaying geographic data. A variety of technologies have resulted such as computer cartography, image processing, spatial modeling, computer graphics, data base management, and geographic information systems. These tools have been used in a wide range of spatial applications involving facility siting, transportation routing, coal resource analysis, environmental impacts, terrain modeling, inventory development, demographic studies, water resource analyses, etc. The report discusses a number of topics dealing with geographic data bases and structures, software and processing techniques, hardware systems, models and analysis tools, data acquisition techniques, and graphical display methods. Numerous results from many different applications are shown to aid the reader interested in using geographic information systems for environmental analyses. 15 refs., 64 figs., 2 tabs.

  19. All-optical signal processing data communication and storage applications

    CERN Document Server

    Eggleton, Benjamin

    2015-01-01

    This book provides a comprehensive review of the state-of-the art of optical signal processing technologies and devices. It presents breakthrough solutions for enabling a pervasive use of optics in data communication and signal storage applications. It presents presents optical signal processing as solution to overcome the capacity crunch in communication networks. The book content ranges from the development of innovative materials and devices, such as graphene and slow light structures, to the use of nonlinear optics for secure quantum information processing and overcoming the classical Shannon limit on channel capacity and microwave signal processing. Although it holds the promise for a substantial speed improvement, today’s communication infrastructure optics remains largely confined to the signal transport layer, as it lags behind electronics as far as signal processing is concerned. This situation will change in the near future as the tremendous growth of data traffic requires energy efficient and ful...

  20. First International Conference Multimedia Processing, Communication and Computing Applications

    CERN Document Server

    Guru, Devanur

    2013-01-01

    ICMCCA 2012 is the first International Conference on Multimedia Processing, Communication and Computing Applications and the theme of the Conference is chosen as ‘Multimedia Processing and its Applications’. Multimedia processing has been an active research area contributing in many frontiers of today’s science and technology. This book presents peer-reviewed quality papers on multimedia processing, which covers a very broad area of science and technology. The prime objective of the book is to familiarize readers with the latest scientific developments that are taking place in various fields of multimedia processing and is widely used in many disciplines such as Medical Diagnosis, Digital Forensic, Object Recognition, Image and Video Analysis, Robotics, Military, Automotive Industries, Surveillance and Security, Quality Inspection, etc. The book will assist the research community to get the insight of the overlapping works which are being carried out across the globe at many medical hospitals and instit...

  1. High prevalence of blaOXA-23 in Acinetobacter spp. and detection of blaNDM-1 in A. soli in Cuba: report from National Surveillance Program (2010–2012

    Directory of Open Access Journals (Sweden)

    D. Quiñones

    2015-09-01

    Full Text Available As a first national surveillance of Acinetobacter in Cuba, a total of 500 Acinetobacter spp. isolates recovered from 30 hospitals between 2010 and 2012 were studied. Acinetobacter baumannii–calcoaceticus complex accounted for 96.4% of all the Acinetobacter isolates, while other species were detected at low frequency (A. junii 1.6%, A. lwoffii 1%, A. haemolyticus 0.8%, A. soli 0.2%. Resistance rates of isolates were 34–61% to third-generation cephalosporins, 49–50% to β-lactams/inhibitor combinations, 42–47% to aminoglycosides, 42–44% to carbapenems and 55% to ciprofloxacin. However, resistance rates to colistin, doxycycline, tetracycline and rifampin were less than 5%. Among carbapenem-resistant isolates, 75% harboured different blaOXA genes (OXA-23, 73%; OXA-24, 18%; OXA-58, 3%. The blaNDM-1 gene was identified in an A. soli strain, of which the species was confirmed by sequence analysis of 16S rRNA gene, rpoB, rpoB–rpoC and rpoL–rpoB intergenic spacer regions and gyrB. The sequences of blaNDM-1 and its surrounding genes were identical to those reported for plasmids of A. baumannii and A. lwoffi strains. This is the first report of blaNDM-1 in A. soli, together with a high prevalence of OXA-23 carbapenemase for carbapenem resistance in Acinetobacter spp. in Cuba.

  2. Prevalence of ESBL phenotype,blaCTX-M-1,blaSHV andblaTEM genes among uropathogenicEscherichia coli isolates from 3 military hospitals of Tehran, Iran

    Institute of Scientific and Technical Information of China (English)

    Farshad Nojoomi; Abdolmajid Ghasemian

    2016-01-01

    Objective:To determine the extended-spectrum beta-lactamase (ESBL) production and prevalence ofblaCTX-M-1,blaSHV andblaTEM genes among uropathogenic Escherichia coli(UPEC) isolates from 3 military hospitals of Tehran during 2015–2016. Methods: One-hundred and eleven isolates were adopted. The antibiotic susceptibility testing was conducted according to Clinical and Laboratory Standards Institute guidelines. The combine disk was used for phenotypicESBL production. The ceftazidimeMIC was conducted with the micro-broth dilution test. ThePCR assay was used to detect theblaCTX-M-1,blaSHV and blaTEM genes. Results:In the broth microdilution method, 103 (92.7%) isolates showed minimal inhibitory concentration (MIC)≥1µg/mL, and also in the combined disk method, 89 (80.1% of all) wereESBL positive. On the other hand, among 91 ceftazidime resistant isolates, 86 (77.4% of all) wereESBLpositive. The difference between the two methods forESBL confirmation was not significant. The result ofMIC was similar to the disk diffusion method in the detection of phenotypicESBL production. AmongESBLproducer isolates, the prevalence ofblaCTX-M-1, blaSHV andblaTEM was 77.4% (n= 86), 47.4% (n= 53) and 2.4% (n= 2), respectively. These genes were amplified in a wide rangeMIC of ceftazidime. Conclusions:The prevalence of multi-drug resistantUPEC andESBL positive isolates was high in military hospitals. The majority ofUPEC isolates amplifiedblaCTX-M-I andblaSHV typeβ-lactamase genes. One-third of isolates were positive in presence of both these genes. There was no relation between ceftazidimeMIC and presence of beta-lactamase genes.

  3. Visas for Switzerland and France - Time needed to process applications

    CERN Multimedia

    2012-01-01

    Please note that any person required to be in possession of a visa in order to take up functions at CERN must start the application process sufficiently early to allow the visa to be issued in time.   The submission of an incomplete application, local circumstances and an increase in applications before the summer holiday period can all result in considerable variation in the time needed to process your application and issue the visa. You are therefore recommended to submit your visa application at least three months, and not later than 21 days, prior to your departure date. We would also like to remind you that the Swiss Consulate in Paris and the French Consulate in Geneva can issue visas exclusively to people resident within their respective spheres of competence (i.e. those who are holders of a French or Swiss residence permit respectively). You must therefore obtain all visas required for stays longer than three months in France or Switzerland from the visa-issuing authority competent for ...

  4. Fractional Processes and Fractional-Order Signal Processing Techniques and Applications

    CERN Document Server

    Sheng, Hu; Qiu, TianShuang

    2012-01-01

    Fractional processes are widely found in science, technology and engineering systems. In Fractional Processes and Fractional-order Signal Processing, some complex random signals, characterized by the presence of a heavy-tailed distribution or non-negligible dependence between distant observations (local and long memory), are introduced and examined from the ‘fractional’ perspective using simulation, fractional-order modeling and filtering and realization of fractional-order systems. These fractional-order signal processing (FOSP) techniques are based on fractional calculus, the fractional Fourier transform and fractional lower-order moments. Fractional Processes and Fractional-order Signal Processing: • presents fractional processes of fixed, variable and distributed order studied as the output of fractional-order differential systems; • introduces FOSP techniques and the fractional signals and fractional systems point of view; • details real-world-application examples of FOSP techniques to demonstr...

  5. Launch Site Computer Simulation and its Application to Processes

    Science.gov (United States)

    Sham, Michael D.

    1995-01-01

    This paper provides an overview of computer simulation, the Lockheed developed STS Processing Model, and the application of computer simulation to a wide range of processes. The STS Processing Model is an icon driven model that uses commercial off the shelf software and a Macintosh personal computer. While it usually takes one year to process and launch 8 space shuttles, with the STS Processing Model this process is computer simulated in about 5 minutes. Facilities, orbiters, or ground support equipment can be added or deleted and the impact on launch rate, facility utilization, or other factors measured as desired. This same computer simulation technology can be used to simulate manufacturing, engineering, commercial, or business processes. The technology does not require an 'army' of software engineers to develop and operate, but instead can be used by the layman with only a minimal amount of training. Instead of making changes to a process and realizing the results after the fact, with computer simulation, changes can be made and processes perfected before they are implemented.

  6. Nanotechnology in meat processing and packaging: potential applications - a review.

    Science.gov (United States)

    Ramachandraiah, Karna; Han, Sung Gu; Chin, Koo Bok

    2015-02-01

    Growing demand for sustainable production, increasing competition and consideration of health concerns have led the meat industries on a path to innovation. Meat industries across the world are focusing on the development of novel meat products and processes to meet consumer demand. Hence, a process innovation, like nanotechnology, can have a significant impact on the meat processing industry through the development of not only novel functional meat products, but also novel packaging for the products. The potential benefits of utilizing nanomaterials in food are improved bioavailability, antimicrobial effects, enhanced sensory acceptance and targeted delivery of bioactive compounds. However, challenges exist in the application of nanomaterials due to knowledge gaps in the production of ingredients such as nanopowders, stability of delivery systems in meat products and health risks caused by the same properties which also offer the benefits. For the success of nanotechnology in meat products, challenges in public acceptance, economics and the regulation of food processed with nanomaterials which may have the potential to persist, accumulate and lead to toxicity need to be addressed. So far, the most promising area for nanotechnology application seems to be in meat packaging, but the long term effects on human health and environment due to migration of the nanomaterials from the packaging needs to be studied further. The future of nanotechnology in meat products depends on the roles played by governments, regulatory agencies and manufacturers in addressing the challenges related to the application of nanomaterials in food. PMID:25557827

  7. Stochastic processes and applications diffusion processes, the Fokker-Planck and Langevin equations

    CERN Document Server

    Pavliotis, Grigorios A

    2014-01-01

    This book presents various results and techniques from the theory of stochastic processes that are useful in the study of stochastic problems in the natural sciences. The main focus is analytical methods, although numerical methods and statistical inference methodologies for studying diffusion processes are also presented. The goal is the development of techniques that are applicable to a wide variety of stochastic models that appear in physics, chemistry and other natural sciences. Applications such as stochastic resonance, Brownian motion in periodic potentials and Brownian motors are studied and the connection between diffusion processes and time-dependent statistical mechanics is elucidated.                 The book contains a large number of illustrations, examples, and exercises. It will be useful for graduate-level courses on stochastic processes for students in applied mathematics, physics and engineering. Many of the topics covered in this book (reversible diffusions, convergence to eq...

  8. Diverse Genetic Array of blaCTXM-15 in Escherichia coli: A Single-Center Study from India.

    Science.gov (United States)

    Maurya, Anand Prakash; Mishra, Shweta; Talukdar, Anupam Das; Dhar Chanda, Debadatta; Chakravarty, Atanu; Bhattacharjee, Amitabha

    2016-01-01

    CTX-M-15 is a chief contributor for expanded-spectrum cephalosporin and monobactam resistance in India, complicating treatment options. In this study, we have investigated genetic context of CTX-M-15 in Escherichia coli and their transmission dynamics in a tertiary referral hospital of India. A total of 198 isolates were collected, of which 66 were harboring blaCTXM-15. Among them, 14 isolates were carrying a single CTX-M-15 gene and 52 were harboring multiple extended-spectrum β-lactamase genes along with blaCTX-M-15. The resistance gene was flanked by tnpA, ISEcp1, IS26, and ORF477 in 10 different arrangements. The resistance determinant was horizontally transferable through F, W, I1, and P Inc types of plasmids. Restriction mapping of plasmids showed a variable band pattern even within the same Inc types. Minimum inhibitory concentration was found above the breakpoint level against expanded-spectrum cephalosporins and monobactam while susceptible against carbapenems. blaCTX-M-15 was highly stable and sustained in the cell after 115 serial passages. In pulse-field gel electrophoresis, eight pulsotypes of E. coli were found to be responsible for the spread of blaCTX-M-15 in the tertiary referral center. We conclude that the presence of CTX-M-15 in the heterogeneous group of E. coli is highly alarming in terms of infection control and it may require regular monitoring, so as to formulate appropriate antibiotic policy to stop the spread of this resistance determinant.

  9. Dissemination of IncI2 Plasmids That Harbor the blaCTX-M Element among Clinical Salmonella Isolates

    OpenAIRE

    Wong, Marcus Ho-yin; Liu, Lizhang; Yan, Meiying; Chan, Edward Wai-chi; Chen, Sheng

    2015-01-01

    The extended-spectrum-β-lactamase (ESBL) determinant CTX-M-55 is increasingly prevalent in Escherichia coli but remains extremely rare in Salmonella. This study reports the isolation of a plasmid harboring the blaCTX-M-55 element in a clinical Salmonella enterica serotype Typhimurium strain resistant to multiple antibiotics. This plasmid is genetically identical to several known IncI2-type elements harbored by E. coli strains recovered from animals. This finding indicates that IncI2 plasmids ...

  10. The sudden dominance of blaCTX-M harbouring plasmids in Shigella spp. Circulating in Southern Vietnam.

    Directory of Open Access Journals (Sweden)

    Nhu Thi Khanh Nguyen

    Full Text Available BACKGROUND: Plasmid mediated antimicrobial resistance in the Enterobacteriaceae is a global problem. The rise of CTX-M class extended spectrum beta lactamases (ESBLs has been well documented in industrialized countries. Vietnam is representative of a typical transitional middle income country where the spectrum of infectious diseases combined with the spread of drug resistance is shifting and bringing new healthcare challenges. METHODOLOGY: We collected hospital admission data from the pediatric population attending the hospital for tropical diseases in Ho Chi Minh City with Shigella infections. Organisms were cultured from all enrolled patients and subjected to antimicrobial susceptibility testing. Those that were ESBL positive were subjected to further investigation. These investigations included PCR amplification for common ESBL genes, plasmid investigation, conjugation, microarray hybridization and DNA sequencing of a bla(CTX-M encoding plasmid. PRINCIPAL FINDINGS: We show that two different bla(CTX-M genes are circulating in this bacterial population in this location. Sequence of one of the ESBL plasmids shows that rather than the gene being integrated into a preexisting MDR plasmid, the bla(CTX-M gene is located on relatively simple conjugative plasmid. The sequenced plasmid (pEG356 carried the bla(CTX-M-24 gene on an ISEcp1 element and demonstrated considerable sequence homology with other IncFI plasmids. SIGNIFICANCE: The rapid dissemination, spread of antimicrobial resistance and changing population of Shigella spp. concurrent with economic growth are pertinent to many other countries undergoing similar development. Third generation cephalosporins are commonly used empiric antibiotics in Ho Chi Minh City. We recommend that these agents should not be considered for therapy of dysentery in this setting.

  11. Application of Heavy Solvent Deasphalting in Sour Resid Processing

    Institute of Scientific and Technical Information of China (English)

    Long Jun; Wang Zijun; Huang Weiqi; Zu Deguang

    2003-01-01

    Complete conversion of resid into light oil needs to consume large amount of hydrogen, because the light oil has higher hydrogen content. The conversion of whole resid into light oil is not economic at the normal price gap between the light and heavy oils. Hence a combination of hydrogenation process with carbon removal process is generally adopted.The heavy solvent deasphalting can selectively remove the asphaltenes and metals contained in resid while providing a large amount of easily convertible deasphalted oil for the down-stream processes.This article refers to the characteristics of heavy solvent deasphalting and its application in sour resid processing, along with various routes for utilization of deoiled asphalt.

  12. Sol-gel materials for optofluidics - process and applications

    DEFF Research Database (Denmark)

    Mikkelsen, Morten Bo Lindholm

    2011-01-01

    This Ph.D. thesis is concerned with the use of sol-gel materials in optofluidic applications and the physics of DNA molecules in nanoconfinement. The bottom-up formation of solid material, which is provided by the sol-gel process, enables control of the chemical composition and porosity...... of the material. At early stages of gelation, thin gel coatings can be structured by nanoimprint lithography, and purely inorganic silica materials can be obtained by subsequent thermal annealing. The sol-gel process thus constitutes a unique method for nanofabrication of silica materials of special properties....... In this work, sol-gel silica is introduced as a new material class for the fabrication of lab-on-a-chip devices for DNA analysis. An imprint process with a rigid, non-permeable stamp was developed, which enabled fabrication of micro- and nanofluidic silica channels in a single process step without use of any...

  13. Hardware Software co-simulation for Image Processing Applications

    Directory of Open Access Journals (Sweden)

    A.C.Suthar

    2012-03-01

    Full Text Available We proposed the concept of hardware software co-simulation for image processing using Xilinx system generator. Recent advances in synthesis tools for SIMULINK suggest a feasible high-level approach to algorithm implementation for embedded DSP systems. An efficient FPGA based hardware design for enhancement of color and grey scale images in image and video processing. The top model - based visual development process of SIMULINK facilitates host side simulation and validation, as well as synthesis of target specific code, furthermore, legacy code written in MATLAB or ANCI C can be reuse in custom blocks. However, the code generated for DSP platforms is often not very efficient. We are implemented the Image processing applications on FPGA it can be easily design

  14. High-temperature process heat applications with an HTGR

    International Nuclear Information System (INIS)

    An 842-MW(t) HTGR-process heat (HTGR-PH) design and several synfuels and energy transport processes to which it could be coupled are described. As in other HTGR designs, the HTGR-PH has its entire primary coolant system contained in a prestressed concrete reactor vessel (PCRV) which provides the necessary biological shielding and pressure containment. The high-temperature nuclear thermal energy is transported to the externally located process plant by a secondary helium transport loop. With a capability to produce hot helium in the secondary loop at 8000C (14720F) with current designs and 9000C (16520F) with advanced designs, a large number of process heat applications are potentially available. Studies have been performed for coal liquefaction and gasification using nuclear heat

  15. Land Use and Land Cover - CEMETERIES_USGS_BLA_IN: Cemetery Locations in Indiana (United States Geological Survey, 1:24000, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Cemeteries_USGSs__BLA_IN is a point shapefile showing the locations and attribute values of cemeteries extracted from the Geographic Names Information System (GNIS)...

  16. Association between β-Lactamase-Encoding blaOXA-51 Variants and DiversiLab Rep-PCR-Based Typing of Acinetobacter baumannii Isolates

    Science.gov (United States)

    Zander, Esther; Nemec, Alexandr; Seifert, Harald

    2012-01-01

    This study investigated the correlation between blaOXA-51 variants and Acinetobacter baumannii worldwide clonal lineages 1 to 8 (WW1 to -8). The blaOXA-51-like genes of 102 A. baumannii isolates were sequenced. Using DiversiLab repetitive-sequence-based PCR (rep-PCR) typing, 92 of these isolates had previously been assigned to WW1 to -8 and 10 were unclustered. Clustering of DNA sequences was performed using the neighbor-joining method and the Jukes-Cantor phylogenetic correction. blaOXA-51 variants were in good correlation with DiversiLab-defined clonal lineages. Sequence-based typing of blaOXA-51 variants has the potential to be applied for epidemiologic characterization of A. baumannii and to identify worldwide clonal lineages 1 to 8. PMID:22422849

  17. Improving Knowledge and Process for International Emergency Medicine Fellowship Applicants: A Call for a Uniform Application

    Directory of Open Access Journals (Sweden)

    Gabrielle A. Jacquet

    2013-01-01

    Full Text Available Background. There are currently 34 International Emergency Medicine (IEM fellowship programs. Applicants and programs are increasing in number and diversity. Without a standardized application, applicants have a difficulty approaching programs in an informed and an organized method; a streamlined application system is necessary. Objectives. To measure fellows’ knowledge of their programs’ curricula prior to starting fellowship and to determine what percent of fellows and program directors would support a universal application system. Methods. A focus group of program directors, recent, and current fellows convened to determine the most important features of an IEM fellowship application process. A survey was administered electronically to a convenience sample of 78 participants from 34 programs. Respondents included fellowship directors, fellows, and recent graduates. Results. Most fellows (70% did not know their program’s curriculum prior to starting fellowship. The majority of program directors and fellows support a uniform application service (81% and 67%, resp. and deadline (85% for both. A minority of program directors (35% and fellows (30% support a formal match. Conclusions. Program directors and fellows support a uniform application service and deadline, but not a formalized match. Forums for disseminating IEM fellowship information and for administering a uniform application service and deadline are currently in development to improve the process.

  18. Molecular Evolution of a Klebsiella pneumoniae ST278 Isolate Harboring blaNDM-7 and Involved in Nosocomial Transmission.

    Science.gov (United States)

    Lynch, Tarah; Chen, Liang; Peirano, Gisele; Gregson, Dan B; Church, Deirdre L; Conly, John; Kreiswirth, Barry N; Pitout, Johann D

    2016-09-01

    During 2013, ST278 Klebsiella pneumoniae with blaNDM-7 was isolated from the urine (KpN01) and rectum (KpN02) of a patient in Calgary, Canada. The same strain (KpN04) was subsequently isolated from another patient in the same unit. Interestingly, a carbapenem-susceptible K. pneumoniae ST278 (KpN06) was obtained 1 month later from the blood of the second patient. Next-generation sequencing (NGS) revealed that the loss of carbapenem-resistance in KpN06 was due to a 5-kb deletion on the blaNDM-7-harboring IncX3 plasmid. In addition, an IncFIB plasmid in KpN06 had a 27-kb deletion that removed genes encoding for heavy metal resistance. Phylogenetic analysis showed that the K. pneumoniae ST278 from patient 2 was likely a descendant of KpN02 and that KpN06 was a close progenitor of an environmental ST278. It is unclear whether KpN06 lost the blaNDM-7 gene in vivo. This study detailed the remarkable plasticity and speed of evolutionary changes in multidrug-resistant K. pneumoniae, demonstrating the highly recombinant nature of this species. It also highlights the ability of NGS to clarify molecular microevolutionary events within antibiotic-resistant organisms. PMID:27284091

  19. Clonal dissemination of Klebsiella pneumoniae ST512 carrying blaKPC-3 in a hospital in southern Italy.

    Science.gov (United States)

    Pulcrano, Giovanna; Iula, Dora Vita; de Luca, Cristiana; Roscetto, Emanuela; Vollaro, Antonio; Rossano, Fabio; Catania, Maria Rosaria

    2014-01-01

    Strains of Klebsiella pneumoniae producing KPC-carbapenemase have emerged as one of the most important multidrug-resistant Gram-negative nosocomial pathogens. Here, we report the first isolation and subsequent dissemination of a K. pneumoniae ST512 producing KPC-3 carbapenemase in a hospital in southern Italy. Isolates were obtained from blood, throat swabs, sputum, catheters, and urine of patients admitted to different hospital wards. Antimicrobial MICs were determined for all isolates by automated systems and confirmed by Etest. Carbapenemase production was confirmed by the modified Hodge test and by a disc synergy test, and carbapenemase genes were investigated by PCR. All isolates were characterized by pulse-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) analysis. Most isolates were multidrug resistant with exception of some isolates intermediately susceptible to gentamicin, tigecycline, and trimethoprim-sulfamethoxazole. PCR analysis showed that isolates harbored the bla(KPC-3) gene associated with bla(TEM) and bla(SVH). PFGE and MLST showed that all isolates belonged to the same ST512 clone recently described in Israel.

  20. Sodium waste management: from process development to industrial application

    International Nuclear Information System (INIS)

    Operation and decommissioning of Liquid Metal Fast Reactors (LMFRs) generate various kinds of sodium wastes. Simple methods dealing with such wastes exist and are currently used in the classical industry or for the dismantling of non-radioactive test loops. However radioactivity implies accurate control of the liquid and gaseous effluents generated, which implies more sophisticated methods and design features. Moreover, high sodium reactivity implies the development of safe processes with simple technology. In support to the needs of the LMFRs in operation, and in preparation to the LMFR decommissioning, the CEA has developed particular skills and specific processes with respect to sodium waste management. On its side, FRAMATOME Direction NOVATOME has applied its LMFR and sodium engineering knowledge to the industrialization of such processes. This paper describes the results obtained so far on the development of processes, together with examples or prospects of application in industrial conditions based on the wide diversity of wastes produced by a LMFR. This review shows that, if the contaminated sodium waste treatment requires the greatest care and well-adapted processes, the techniques exist or are being developed, with already satisfactory industrial application records. (authors)

  1. Process for application of powder particles to filamentary materials

    Science.gov (United States)

    Baucom, Robert M. (Inventor); Snoha, John J. (Inventor); Marchello, Joseph M. (Inventor)

    1991-01-01

    This invention is a process for the uniform application of polymer powder particles to a filamentary material in a continuous manner to form a uniform composite prepreg material. A tow of the filamentary material is fed under carefully controlled tension into a spreading unit, where it is spread pneumatically into an even band. The spread filamentary tow is then coated with polymer particles from a fluidized bed, after which the coated filamentary tow is fused before take-up on a package for subsequent utilization. This process produces a composite prepreg uniformly without imposing severe stress on the filamentary material, and without requiring long, high temperature residence times for the polymer.

  2. Application of PLM processes to respond to mechanical SMEs needs

    CERN Document Server

    Duigou, Julien Le; Perry, Nicolas; Delplace, Jean-Charles

    2010-01-01

    PLM is today a reality for mechanical SMEs. Some companies implement PLM systems very well but others have more difficulties. This paper aims to explain why some SMEs do not success to integrated PLM systems analyzing the needs of mechanical SMEs, the processes to implement to respond to those needs and the actual PLM software functionalities. The proposition of a typology of those companies and the responses of those needs by PLM processes will be explain through the applications of a demonstrator applying appropriate generic data model and modelling framework.

  3. Stochastic analysis for gaussian random processes and fields with applications

    CERN Document Server

    Mandrekar, Vidyadhar S

    2015-01-01

    Stochastic Analysis for Gaussian Random Processes and Fields: With Applications presents Hilbert space methods to study deep analytic properties connecting probabilistic notions. In particular, it studies Gaussian random fields using reproducing kernel Hilbert spaces (RKHSs).The book begins with preliminary results on covariance and associated RKHS before introducing the Gaussian process and Gaussian random fields. The authors use chaos expansion to define the Skorokhod integral, which generalizes the Itô integral. They show how the Skorokhod integral is a dual operator of Skorokhod differenti

  4. Bacteriophages-potential for application in wastewater treatment processes

    Energy Technology Data Exchange (ETDEWEB)

    Withey, S. [School of Water Sciences, Cranfield University, Cranfield, Bedfordshire, MK43 0AL (United Kingdom); Cartmell, E. [School of Water Sciences, Cranfield University, Cranfield, Bedfordshire, MK43 0AL (United Kingdom)]. E-mail: e.cartmell@cranfield.ac.uk; Avery, L.M. [School of Water Sciences, Cranfield University, Cranfield, Bedfordshire, MK43 0AL (United Kingdom); Stephenson, T. [School of Water Sciences, Cranfield University, Cranfield, Bedfordshire, MK43 0AL (United Kingdom)

    2005-03-01

    Bacteriophages are viruses that infect and lyse bacteria. Interest in the ability of phages to control bacterial populations has extended from medical applications into the fields of agriculture, aquaculture and the food industry. Here, the potential application of phage techniques in wastewater treatment systems to improve effluent and sludge emissions into the environment is discussed. Phage-mediated bacterial mortality has the potential to influence treatment performance by controlling the abundance of key functional groups. Phage treatments have the potential to control environmental wastewater process problems such as: foaming in activated sludge plants; sludge dewaterability and digestibility; pathogenic bacteria; and to reduce competition between nuisance bacteria and functionally important microbial populations. Successful application of phage therapy to wastewater treatment does though require a fuller understanding of wastewater microbial community dynamics and interactions. Strategies to counter host specificity and host cell resistance must also be developed, as should safety considerations regarding pathogen emergence through transduction.

  5. Review of Matrix Decomposition Techniques for Signal Processing Applications

    Directory of Open Access Journals (Sweden)

    Monika Agarwal,

    2014-01-01

    Full Text Available Decomposition of matrix is a vital part of many scientific and engineering applications. It is a technique that breaks down a square numeric matrix into two different square matrices and is a basis for efficiently solving a system of equations, which in turn is the basis for inverting a matrix. An inverting matrix is a part of many important algorithms. Matrix factorizations have wide applications in numerical linear algebra, in solving linear systems, computing inertia, and rank estimation is an important consideration. This paper presents review of all the matrix decomposition techniques used in signal processing applications on the basis of their computational complexity, advantages and disadvantages. Various Decomposition techniques such as LU Decomposition, QR decomposition , Cholesky decomposition are discussed here. Keywords –

  6. Techniques of EMG signal analysis: detection, processing, classification and applications

    Science.gov (United States)

    Hussain, M.S.; Mohd-Yasin, F.

    2006-01-01

    Electromyography (EMG) signals can be used for clinical/biomedical applications, Evolvable Hardware Chip (EHW) development, and modern human computer interaction. EMG signals acquired from muscles require advanced methods for detection, decomposition, processing, and classification. The purpose of this paper is to illustrate the various methodologies and algorithms for EMG signal analysis to provide efficient and effective ways of understanding the signal and its nature. We further point up some of the hardware implementations using EMG focusing on applications related to prosthetic hand control, grasp recognition, and human computer interaction. A comparison study is also given to show performance of various EMG signal analysis methods. This paper provides researchers a good understanding of EMG signal and its analysis procedures. This knowledge will help them develop more powerful, flexible, and efficient applications. PMID:16799694

  7. Towards Process Support for Migrating Applications to Cloud Computing

    DEFF Research Database (Denmark)

    Chauhan, Muhammad Aufeef; Babar, Muhammad Ali

    2012-01-01

    Cloud computing is an active area of research for industry and academia. There are a large number of organizations providing cloud computing infrastructure and services. In order to utilize these infrastructure resources and services, existing applications need to be migrated to clouds. However...... for supporting migration to cloud computing based on our experiences from migrating an Open Source System (OSS), Hackystat, to two different cloud computing platforms. We explained the process by performing a comparative analysis of our efforts to migrate Hackystate to Amazon Web Services and Google App Engine....... We also report the potential challenges, suitable solutions, and lesson learned to support the presented process framework. We expect that the reported experiences can serve guidelines for those who intend to migrate software applications to cloud computing....

  8. Low-Temperature Solution Processable Electrodes for Piezoelectric Sensors Applications

    Science.gov (United States)

    Tuukkanen, Sampo; Julin, Tuomas; Rantanen, Ville; Zakrzewski, Mari; Moilanen, Pasi; Lupo, Donald

    2013-05-01

    Piezoelectric thin-film sensors are suitable for a wide range of applications from physiological measurements to industrial monitoring systems. The use of flexible materials in combination with high-throughput printing technologies enables cost-effective manufacturing of custom-designed, highly integratable piezoelectric sensors. This type of sensor can, for instance, improve industrial process control or enable the embedding of ubiquitous sensors in our living environment to improve quality of life. Here, we discuss the benefits, challenges and potential applications of piezoelectric thin-film sensors. The piezoelectric sensor elements are fabricated by printing electrodes on both sides of unmetallized poly(vinylidene fluoride) film. We show that materials which are solution processable in low temperatures, biocompatible and environmental friendly are suitable for use as electrode materials in piezoelectric sensors.

  9. Emerging applications of radiation processing. Proceedings of a technical meeting

    International Nuclear Information System (INIS)

    Approximately 160 gamma irradiators and 1200 electron accelerator based processing units are in operation worldwide. In recent years the IAEA has prepared a directory of industrial gamma irradiators and held several meetings on developments in radiation technology applications. Developments involving the engineering of new sources (both isotope and electrical), high power accelerator applications, etc. have been reported recently, making a review and evaluation of this progress timely. Therefore the IAEA organized a technical meeting in Vienna, Austria, from 28 to 30 April 2003 to review the present situation and the potential contribution of radiation technology to sustainable development. Engineering developments and other features of radiation sources, both isotope and accelerator, were discussed. Recent research has concentrated on three fields: medical and food products, polymers, and environmental pollution control. The stability of radiation sterilized medical implants, as well as the uses of radiation processing for sterilization or decontamination of pharmaceuticals and pharmaceutical raw materials, radiation synthesis and modification of polymers for biomedical applications have been studied. Since separation and enrichment technologies play an important role in product recovery and pollution control, the possibility of radiation synthesis of stimuli-responsive membranes, hydrogels and adsorbents is being investigated. Finally, aside from the technologies for flue gas and wastewater treatment already in use, further research is ongoing on the treatment of organic contaminants in both gaseous and liquid phases. Environmental applications, which also offer new opportunities, should be carefully reviewed to reflect existing regulations and current knowledge. The increasingly serious problem of polyaromatic hydrocarbons (PAH) emissions may be solved in part by the application of radiation technology. This is being studied on a pilot scale for the removal of

  10. A thermal energy storage process for large scale electric applications

    OpenAIRE

    Desrues, T; Ruer, J; Marty, P.; Fourmigué, JF

    2009-01-01

    Abstract A new type of thermal energy storage process for large scale electric applications is presented, based on a high temperature heat pump cycle which transforms electrical energy into thermal energy and stores it inside two large regenerators, followed by a thermal engine cycle which transforms the stored thermal energy back into electrical energy. The storage principle is described, and its thermodynamic cycle is analyzed, leading to the theoretical efficiency of the storage...

  11. Particularities of Verification Processes for Distributed Informatics Applications

    OpenAIRE

    IVAN, ION; Cristian CIUREA; Bogdan VINTILA; Gheorghe NOSCA

    2013-01-01

    This paper presents distributed informatics applications and characteristics of their development cycle. It defines the concept of verification and there are identified the differences from software testing. Particularities of the software testing and software verification processes are described. The verification steps and necessary conditions are presented and there are established influence factors of quality verification. Software optimality verification is analyzed and some metrics are d...

  12. Application of natural zeolites in anaerobic digestion processes: A review

    OpenAIRE

    Montalvo, Silvio; Borja Padilla, Rafael; Sánchez, Enrique; Milán, Zhenia; Cortés, Isel; Rubia, M. Ángeles de la

    2012-01-01

    This paper reviews the most relevant uses and applications of zeolites in anaerobic digestion processes. The feasibility of using natural zeolites as support media for the immobilization of microorganisms in different high-rate reactor configurations (fixed bed, fluidized bed, etc.) is also reviewed. Zeolite, with its favorable characteristics for microorganism adhesion, has also been widely used as an ion exchanger for the removal of ammonium in anaerobic digestion due to the presence of Na ...

  13. Image Processing Using Pearson's Correlation Coefficient: Applications on Autonomous Robotics

    OpenAIRE

    Miranda Neto, Arthur; Corrêa Victorino, Alessandro; Fantoni, Isabelle; Zampieri, Douglas Eduardo; Ferreira, Janito Vaqueiro; Lima, Danilo Alves

    2013-01-01

    International audience Autonomous robots have motivated researchers from different groups due to the challenge that it represents. Many applications for control of autonomous platform are being developed and one important aspect is the excess of information, frequently redundant, that imposes a great computational cost in data processing. Taking into account the temporal coherence between consecutive frames, we have proposed a set of tools based on Pearson's Correlation Coefficient (PCC): ...

  14. Intelligent Computational Systems. Opening Remarks: CFD Application Process Workshop

    Science.gov (United States)

    VanDalsem, William R.

    1994-01-01

    This discussion will include a short review of the challenges that must be overcome if computational physics technology is to have a larger impact on the design cycles of U.S. aerospace companies. Some of the potential solutions to these challenges may come from the information sciences fields. A few examples of potential computational physics/information sciences synergy will be presented, as motivation and inspiration for the Improving The CFD Applications Process Workshop.

  15. Digital Light Processing update: status and future applications

    Science.gov (United States)

    Hornbeck, Larry J.

    1999-05-01

    Digital Light Processing (DLP) projection displays based on the Digital Micromirror Device (DMD) were introduced to the market in 1996. Less than 3 years later, DLP-based projectors are found in such diverse applications as mobile, conference room, video wall, home theater, and large-venue. They provide high-quality, seamless, all-digital images that have exceptional stability as well as freedom from both flicker and image lag. Marked improvements have been made in the image quality of DLP-based projection display, including brightness, resolution, contrast ratio, and border image. DLP-based mobile projectors that weighted about 27 pounds in 1996 now weight only about 7 pounds. This weight reduction has been responsible for the definition of an entirely new projector class, the ultraportable. New applications are being developed for this important new projection display technology; these include digital photofinishing for high process speed minilab and maxilab applications and DLP Cinema for the digital delivery of films to audiences around the world. This paper describes the status of DLP-based projection display technology, including its manufacturing, performance improvements, and new applications, with emphasis on DLP Cinema.

  16. Lysine N[superscript zeta]-Decarboxylation Switch and Activation of the [beta]-Lactam Sensor Domain of BlaR1 Protein of Methicillin-resistant Staphylococcus aureus

    Energy Technology Data Exchange (ETDEWEB)

    Borbulevych, Oleg; Kumarasiri, Malika; Wilson, Brian; Llarrull1, Leticia I.; Lee, Mijoon; Hesek, Dusan; Shi, Qicun; Peng, Jeffrey; Baker, Brian M.; Mobashery, Shahriar (Notre)

    2012-10-29

    The integral membrane protein BlaR1 of methicillin-resistant Staphylococcus aureus senses the presence of {beta}-lactam antibiotics in the milieu and transduces the information to the cytoplasm, where the biochemical events that unleash induction of antibiotic resistance mechanisms take place. We report herein by two-dimensional and three-dimensional NMR experiments of the sensor domain of BlaR1 in solution and by determination of an x-ray structure for the apo protein that Lys-392 of the antibiotic-binding site is posttranslationally modified by N{sup {zeta}}-carboxylation. Additional crystallographic and NMR data reveal that on acylation of Ser-389 by antibiotics, Lys-392 experiences N{sup {zeta}}-decarboxylation. This unique process, termed the lysine N{sup {zeta}}-decarboxylation switch, arrests the sensor domain in the activated ('on') state, necessary for signal transduction and all the subsequent biochemical processes. We present structural information on how this receptor activation process takes place, imparting longevity to the antibiotic-receptor complex that is needed for the induction of the antibiotic-resistant phenotype in methicillin-resistant S. aureus.

  17. Complete Sequence of a Novel IncR-F33:A–:B– Plasmid, pKP1034, Harboring fosA3, blaKPC-2, blaCTX-M-65, blaSHV-12, and rmtB from an Epidemic Klebsiella pneumoniae Sequence Type 11 Strain in China

    Science.gov (United States)

    Xiang, Dai-Rong; Li, Jun-Jie; Sheng, Zi-Ke; Yu, Hai-Ying; Deng, Mei; Bi, Sheng; Hu, Fei-Shu; Chen, Wei; Xue, Xiao-Wei; Zhou, Zhi-Bo; Doi, Yohei; Li, Lan-Juan

    2015-01-01

    A high fosfomycin resistance rate was observed in Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) in our previous study, but little is known about its mechanisms. In this study, we explored the prevalence of plasmid-mediated fosfomycin resistance determinants among fosfomycin-resistant KPC-KP strains from a Chinese university hospital and determined the complete sequence of a novel fosA3-carrying plasmid isolated from an epidemic K. pneumoniae sequence type (ST) 11 strain. A total of 97 KPC-KP strains were studied, of which 57 (58.8%) were resistant to fosfomycin, including 44 (45.4%) harboring fosA3 and 1 harboring fosA. All fosA3-positive strains belonged to the dominant ST11-pulse type (PT) A clone according to multilocus sequence typing and pulsed-field gel electrophoresis, suggesting clonal dissemination. The fosA-positive isolate belonged to ST11-PTE. The fosA3-carrying plasmid pKP1034 is 136,848 bp in length and is not self-transmissible. It is a multireplicon plasmid belonging to IncR-F33:A−: B−. Besides fosA3, a variety of other resistance determinants, including blaKPC-2, rmtB, blaCTX-M-65, and blaSHV-12, are identified in pKP1034, which would allow for coselection of fosA3 by most β-lactams and/or aminoglycosides and facilitate its dissemination despite limited use of fosfomycin in China. Detailed comparisons with related plasmids revealed that pKP1034 is highly mosaic and might have evolved from alarming recombination of the blaKPC-2-carrying plasmid pKPC-LK30 from Taiwan and the epidemic fosA3-carrying plasmid pHN7A8 from mainland China. PMID:26666939

  18. Road sign identification application using image processing and augmented reality

    Directory of Open Access Journals (Sweden)

    Nanditha Rasanjana

    2015-11-01

    Full Text Available Now days, Sri Lanka is a rapidly developing country in the world. With this regard, roads are developing in every area. Every year, many new vehicles are entering to the roads. People use roads for their transport requirements. The road signs boards are helped to control road traffic and accident. But today, road accidents are increasing   rapidly. Most people are getting injured. Some people lost their life due to accidents. So many properties are damaged. Therefore, lives, properties, time and money are lost. A main reason of road accidents is a lack of knowledge about road signs and rules. To overcome this problem, “the developed team” has developed a learning Android Mobile Application. It is named “Mansalakuna”. This Mobile Application can be identified road signs using mobile phone camera. The road signs which focused by mobile phone camera, can be identified using the Image Processing Technology. Then, the mobile application is delivered full information about the road signs on user’s mobile phone screen for use the Augmented Reality Technology. The results can be delivered instantly to the user with specific rules, laws and regulations related for that road sign. Otherwise “Mansalakuna” mobile application can be used for learning mobile applications for passengers and drivers on the way. Countries like Sri Lanka, there are no complete above mention mobile applications package for the road users. Therefore, this Android Mobile Application is given a considerable support to users. It is a start to digital era to the road users.

  19. Sequence of closely related plasmids encoding bla(NDM-1 in two unrelated Klebsiella pneumoniae isolates in Singapore.

    Directory of Open Access Journals (Sweden)

    Ying-Tsong Chen

    Full Text Available BACKGROUND: Spread of the bla(NDM-1 gene that encodes the New Delhi metallo-β-lactamase (NDM-1 in Enterobacteriaceae is a major global health problem. Plasmids carrying bla(NDM-1 from two different multi-drug resistant Klebsiella pneumonia isolates collected in Singapore were completely sequenced and compared to known plasmids carrying bla(NDM-1. METHODOLOGY/PRINCIPAL FINDINGS: The two plasmids, pTR3 and pTR4, were transferred to Escherichia coli recipient strain J53 and completely sequenced by a shotgun approach using 3-kb paired-end libraries on 454. Although the K. pneumoniae strains were unrelated by molecular typing using PFGE and MLST, complete sequencing revealed that pTR3 and pTR4 are identical. The plasmid sequence is similar to the E. coli NDM-1-encoding plasmid p271A, which was isolated in Australia from a patient returning from Bangladesh. The immediate regions of the bla(NDM-1 gene in pTR3/4 are identical to that of p271A, but the backbone of our plasmid is much more similar to another IncN2 plasmid reported recently, pJIE137, which contained an additional 5.2-kb CUP (conserved upstream repeat regulon region in comparison to p271A. A 257-bp element bounded by imperfect 39-bp inverted repeats (IR and an incomplete version of this element flanking the 3.6-kb NDM-1-encoding region were identified in these plasmids and are likely to be the vestiges of an unknown IS. CONCLUSIONS: Although the hosts are not epidemiologically linked, we found that the plasmids bearing the bla(NDM-1 gene are identical. Comparative analyses of the conserved NDM-1-encoding region among different plasmids from K. pneumoniae and E. coli suggested that the transposable elements and the two unknown IR-associated elements flanking the NDM-1-encoding region might have aided the spreading of this worrisome resistance determinant.

  20. Classical and spatial stochastic processes with applications to biology

    CERN Document Server

    Schinazi, Rinaldo B

    2014-01-01

    The revised and expanded edition of this textbook presents the concepts and applications of random processes with the same illuminating simplicity as its first edition, but with the notable addition of substantial modern material on biological modeling. While still treating many important problems in fields such as engineering and mathematical physics, the book also focuses on the highly relevant topics of cancerous mutations, influenza evolution, drug resistance, and immune response. The models used elegantly apply various classical stochastic models presented earlier in the text, and exercises are included throughout to reinforce essential concepts. The second edition of Classical and Spatial Stochastic Processes is suitable as a textbook for courses in stochastic processes at the advanced-undergraduate and graduate levels, or as a self-study resource for researchers and practitioners in mathematics, engineering, physics, and mathematical biology. Reviews of the first edition: An appetizing textbook for a f...

  1. Stochasticity in processes fundamentals and applications to chemistry and biology

    CERN Document Server

    Schuster, Peter

    2016-01-01

    This book has developed over the past fifteen years from a modern course on stochastic chemical kinetics for graduate students in physics, chemistry and biology. The first part presents a systematic collection of the mathematical background material needed to understand probability, statistics, and stochastic processes as a prerequisite for the increasingly challenging practical applications in chemistry and the life sciences examined in the second part. Recent advances in the development of new techniques and in the resolution of conventional experiments at nano-scales have been tremendous: today molecular spectroscopy can provide insights into processes down to scales at which current theories at the interface of physics, chemistry and the life sciences cannot be successful without a firm grasp of randomness and its sources. Routinely measured data is now sufficiently accurate to allow the direct recording of fluctuations. As a result, the sampling of data and the modeling of relevant processes are doomed t...

  2. Grid Computing Application for Brain Magnetic Resonance Image Processing

    International Nuclear Information System (INIS)

    This work emphasizes the use of grid computing and web technology for automatic post-processing of brain magnetic resonance images (MRI) in the context of neuropsychiatric (Alzheimer's disease) research. Post-acquisition image processing is achieved through the interconnection of several individual processes into pipelines. Each process has input and output data ports, options and execution parameters, and performs single tasks such as: a) extracting individual image attributes (e.g. dimensions, orientation, center of mass), b) performing image transformations (e.g. scaling, rotation, skewing, intensity standardization, linear and non-linear registration), c) performing image statistical analyses, and d) producing the necessary quality control images and/or files for user review. The pipelines are built to perform specific sequences of tasks on the alphanumeric data and MRIs contained in our database. The web application is coded in PHP and allows the creation of scripts to create, store and execute pipelines and their instances either on our local cluster or on high-performance computing platforms. To run an instance on an external cluster, the web application opens a communication tunnel through which it copies the necessary files, submits the execution commands and collects the results. We present result on system tests for the processing of a set of 821 brain MRIs from the Alzheimer's Disease Neuroimaging Initiative study via a nonlinear registration pipeline composed of 10 processes. Our results show successful execution on both local and external clusters, and a 4-fold increase in performance if using the external cluster. However, the latter's performance does not scale linearly as queue waiting times and execution overhead increase with the number of tasks to be executed.

  3. Big Bicycle Data Processing: from Personal Data to Urban Applications

    Science.gov (United States)

    Pettit, C. J.; Lieske, S. N.; Leao, S. Z.

    2016-06-01

    Understanding the flows of people moving through the built environment is a vital source of information for the planners and policy makers who shape our cities. Smart phone applications enable people to trace themselves through the city and these data can potentially be then aggregated and visualised to show hot spots and trajectories of macro urban movement. In this paper our aim is to develop procedures for cleaning, aggregating and visualising human movement data and translating this into policy relevant information. In conducting this research we explore using bicycle data collected from a smart phone application known as RiderLog. We focus on the RiderLog application initially in the context of Sydney, Australia and discuss the procedures and challenges in processing and cleaning this data before any analysis can be made. We then present some preliminary map results using the CartoDB online mapping platform where data are aggregated and visualised to show hot spots and trajectories of macro urban movement. We conclude the paper by highlighting some of the key challenges in working with such data and outline some next steps in processing the data and conducting higher volume and more extensive analysis.

  4. Pyroelectric Materials for Uncooled Infrared Detectors: Processing, Properties, and Applications

    Science.gov (United States)

    Aggarwal, M. D.; Batra, A. K.; Guggilla, P.; Edwards, M. E.; Penn, B. G.; Currie, J. R., Jr.

    2010-01-01

    Uncooled pyroelectric detectors find applications in diverse and wide areas such as industrial production; automotive; aerospace applications for satellite-borne ozone sensors assembled with an infrared spectrometer; health care; space exploration; imaging systems for ships, cars, and aircraft; and military and security surveillance systems. These detectors are the prime candidates for NASA s thermal infrared detector requirements. In this Technical Memorandum, the physical phenomena underlying the operation and advantages of pyroelectric infrared detectors is introduced. A list and applications of important ferroelectrics is given, which is a subclass of pyroelectrics. The basic concepts of processing of important pyroelectrics in various forms are described: single crystal growth, ceramic processing, polymer-composites preparation, and thin- and thick-film fabrications. The present status of materials and their characteristics and detectors figures-of-merit are presented in detail. In the end, the unique techniques demonstrated for improving/enhancing the performance of pyroelectric detectors are illustrated. Emphasis is placed on recent advances and emerging technologies such as thin-film array devices and novel single crystal sensors.

  5. Distributed, Modular, Network Enabled Architecture For Process Control Military Applications

    Directory of Open Access Journals (Sweden)

    Abhijit Kamble*,

    2014-02-01

    Full Text Available In process control world, use of distributed modular embedded controller architecture drastically reduces the number and complexity of cabling; at the same time increases the system computing performance and response for real time application as compared to centralized control system. We propose a design based on ARM Cortex M4 hardware architecture and Cortex Microcontroller Software Interface Standard (CMSIS based software development. The ARM Cortex-M series ensures a compatible target processor and provides common core peripherals whereas CMSIS abstraction layer reduces development time, helps design software reusability and provides seamless application software interface for controllers. Being a custom design, we can built features like Built-In Test Equipment (BITE, single point fault tolerance, redundancy, 2/3 logic, etc. which are more desirable for a military applications. This paper describes the design of a generic embedded hardware module that can be configured as local I/O controller or application controller or Man Machine Interface (MMI. This paper also proposes a philosophy for step by step hardware and software development.

  6. Karman vortex street parametrization with image processing application

    Science.gov (United States)

    Pankanin, Grzegorz; Kulinczak, Artur; Berlinski, Jerzy

    2003-09-01

    The karman vortex street phenomenon is applied in the vortex flowmeter. Application of various methods of investigations is necessary in the course of getting increased knowledge of the phenomenon. Flow visualization being the leading method of aero- and hydrodynamic phenomena investigations enables qualitative evaluation in micro-scale. Due to the image processing application in analysis of flow visualization pictures, calculation of geometrical parameters of the Karman vortex street is feasible. So, the quantitative information is obtained. The worked out methodology of investigations as well as designed software for analysis of vortex street pictures are described in the paper. The results of the carried out laboratory tests are reported. Flow visualization has been carried out on the especially designed laboratory tests are reported. Flow visualization has been carried out on the especially designed laboratory stand. The visualized flow has been recorded on the magnetic tape and then processed into set of consecutive frames. Four groups of frames of similar vortex development phases have been put on the image processing procedure. Distances between adjoining vortices have been calculated. On the basis of obtained results it can be stated, that in spite of probabilistic nature of the investigated phenomenon strengthened by the applied research method (flow visualization), the proposed method enables quantitative determination of Karman vortex street parameters.

  7. A survey of decontamination processes applicable to DOE nuclear facilities

    Energy Technology Data Exchange (ETDEWEB)

    Chen, L.; Chamberlain, D.B.; Conner, C.; Vandegrift, G.F.

    1997-05-01

    The objective of this survey was to select an appropriate technology for in situ decontamination of equipment interiors as part of the decommissioning of U.S. Department of Energy nuclear facilities. This selection depends on knowledge of existing chemical decontamination methods. This report provides an up-to-date review of chemical decontamination methods. According to available information, aqueous systems are probably the most universally used method for decontaminating and cleaning metal surfaces. We have subdivided the technologies, on the basis of the types of chemical solvents, into acid, alkaline permanganate, highly oxidizing, peroxide, and miscellaneous systems. Two miscellaneous chemical decontamination methods (electrochemical processes and foam and gel systems) are also described. A concise technical description of various processes is given, and the report also outlines technical considerations in the choice of technologies, including decontamination effectiveness, waste handing, fields of application, and the advantages and limitations in application. On the basis of this survey, six processes were identified for further evaluation. 144 refs., 2 tabs.

  8. Applications of Ecological Engineering Remedies for Uranium Processing Sites, USA

    Energy Technology Data Exchange (ETDEWEB)

    Waugh, William [Navarro Research and Engineering

    2016-05-23

    The U.S. Department of Energy (USDOE) is responsible for remediation of environmental contamination and long-term stewardship of sites associated with the legacy of nuclear weapons production during the Cold War in the United States. Protection of human health and the environment will be required for hundreds or even thousands of years at many legacy sites. USDOE continually evaluates and applies advances in science and technology to improve the effectiveness and sustainability of surface and groundwater remedies (USDOE 2011). This paper is a synopsis of ecological engineering applications that USDOE is evaluating to assess the effectiveness of remedies at former uranium processing sites in the southwestern United States. Ecological engineering remedies are predicated on the concept that natural ecological processes at legacy sites, once understood, can be beneficially enhanced or manipulated. Advances in tools for characterizing key processes and for monitoring remedy performance are demonstrating potential. We present test cases for four ecological engineering remedies that may be candidates for international applications.

  9. A survey of decontamination processes applicable to DOE nuclear facilities

    International Nuclear Information System (INIS)

    The objective of this survey was to select an appropriate technology for in situ decontamination of equipment interiors as part of the decommissioning of U.S. Department of Energy nuclear facilities. This selection depends on knowledge of existing chemical decontamination methods. This report provides an up-to-date review of chemical decontamination methods. According to available information, aqueous systems are probably the most universally used method for decontaminating and cleaning metal surfaces. We have subdivided the technologies, on the basis of the types of chemical solvents, into acid, alkaline permanganate, highly oxidizing, peroxide, and miscellaneous systems. Two miscellaneous chemical decontamination methods (electrochemical processes and foam and gel systems) are also described. A concise technical description of various processes is given, and the report also outlines technical considerations in the choice of technologies, including decontamination effectiveness, waste handing, fields of application, and the advantages and limitations in application. On the basis of this survey, six processes were identified for further evaluation. 144 refs., 2 tabs

  10. Processing Techniques and Applications of Silk Hydrogels in Bioengineering.

    Science.gov (United States)

    Floren, Michael; Migliaresi, Claudio; Motta, Antonella

    2016-01-01

    Hydrogels are an attractive class of tunable material platforms that, combined with their structural and functional likeness to biological environments, have a diversity of applications in bioengineering. Several polymers, natural and synthetic, can be used, the material selection being based on the required functional characteristics of the prepared hydrogels. Silk fibroin (SF) is an attractive natural polymer for its excellent processability, biocompatibility, controlled degradation, mechanical properties and tunable formats and a good candidate for the fabrication of hydrogels. Tremendous effort has been made to control the structural and functional characteristic of silk hydrogels, integrating novel biological features with advanced processing techniques, to develop the next generation of functional SF hydrogels. Here, we review the several processing methods developed to prepare advanced SF hydrogel formats, emphasizing a bottom-up approach beginning with critical structural characteristics of silk proteins and their behavior under specific gelation environments. Additionally, the preparation of SF hydrogel blends and other advanced formats will also be discussed. We conclude with a brief description of the attractive utility of SF hydrogels in relevant bioengineering applications. PMID:27649251

  11. Processing Techniques and Applications of Silk Hydrogels in Bioengineering

    Science.gov (United States)

    Floren, Michael; Migliaresi, Claudio; Motta, Antonella

    2016-01-01

    Hydrogels are an attractive class of tunable material platforms that, combined with their structural and functional likeness to biological environments, have a diversity of applications in bioengineering. Several polymers, natural and synthetic, can be used, the material selection being based on the required functional characteristics of the prepared hydrogels. Silk fibroin (SF) is an attractive natural polymer for its excellent processability, biocompatibility, controlled degradation, mechanical properties and tunable formats and a good candidate for the fabrication of hydrogels. Tremendous effort has been made to control the structural and functional characteristic of silk hydrogels, integrating novel biological features with advanced processing techniques, to develop the next generation of functional SF hydrogels. Here, we review the several processing methods developed to prepare advanced SF hydrogel formats, emphasizing a bottom-up approach beginning with critical structural characteristics of silk proteins and their behavior under specific gelation environments. Additionally, the preparation of SF hydrogel blends and other advanced formats will also be discussed. We conclude with a brief description of the attractive utility of SF hydrogels in relevant bioengineering applications. PMID:27649251

  12. Processing Techniques and Applications of Silk Hydrogels in Bioengineering

    Directory of Open Access Journals (Sweden)

    Michael Floren

    2016-09-01

    Full Text Available Hydrogels are an attractive class of tunable material platforms that, combined with their structural and functional likeness to biological environments, have a diversity of applications in bioengineering. Several polymers, natural and synthetic, can be used, the material selection being based on the required functional characteristics of the prepared hydrogels. Silk fibroin (SF is an attractive natural polymer for its excellent processability, biocompatibility, controlled degradation, mechanical properties and tunable formats and a good candidate for the fabrication of hydrogels. Tremendous effort has been made to control the structural and functional characteristic of silk hydrogels, integrating novel biological features with advanced processing techniques, to develop the next generation of functional SF hydrogels. Here, we review the several processing methods developed to prepare advanced SF hydrogel formats, emphasizing a bottom-up approach beginning with critical structural characteristics of silk proteins and their behavior under specific gelation environments. Additionally, the preparation of SF hydrogel blends and other advanced formats will also be discussed. We conclude with a brief description of the attractive utility of SF hydrogels in relevant bioengineering applications.

  13. Epidemiological characteristics of blaNDM-1 in Enterobacteriaceae and the Acinetobacter calcoaceticus-Acinetobacter baumannii complex in China from 2011 to 2012.

    Directory of Open Access Journals (Sweden)

    Weimei Ou

    Full Text Available OBJECTIVES: The study aimed to investigate the prevalence and epidemiological characteristics of blaNDM-1 (encoding New Delhi metallo-β-lactamase 1 in Enterobacteriaceae and the Acinetobacter calcoaceticus-Acinetobacter baumannii complex (ABC in China from July 2011 to June 2012. METHODS: PCR was used to screen for the presence of blaNDM-1 in all organisms studied. For blaNDM-1-positive strains, 16S rRNA analysis and Analytical Profile Index (API strips were used to identify the bacterial genus and species. The ABCs were reconfirmed by PCR detection of blaOXA-51-like. Antibiotic susceptibilities of the bacteria were assessed by determining minimum inhibitory concentration (MIC of them using two-fold agar dilution test, as recommended by the Clinical and Laboratory Standards Institute (CLSI. Molecular typing was performed using pulsed-field gel electrophoresis (PFGE. S1 nuclease-pulsed-field gel electrophoresis (S1-PFGE and Southern blot hybridization were conducted to ascertain the gene location of blaNDM-1. Conjugation experiments were conducted to determine the transmission of blaNDM-1-positive strains. RESULTS: Among 2,170 Enterobacteriaceae and 600 ABCs, seven Enterobacteriaceae strains and two A. calcoaceticus isolates from five different cities carried the blaNDM-1 gene. The seven Enterobacteriaceae strains comprised four Klebsiella pneumoniae, one Enterobacter cloacae, one Enterobacter aerogen and one Citrobacter freundii. All seven were non-susceptible to imipenem, meropenem or ertapenem. Two A. calcoaceticus species were resistant to imipenem and meropenem. Three K. pneumoniae showed the same PFGE profiles. The blaNDM-1 genes of eight strains were localized on plasmids, while one was chromosomal. CONCLUSIONS: Compared with previous reports, the numbers and species containing the blaNDM-1 in Enterobacteriaceae have significantly increased in China. Most of them are able to disseminate the gene, which is cause for concern. Consecutive

  14. Dispersal of carbapenemase blaVIM-1 gene associated with different Tn402 variants, mercury transposons, and conjugative plasmids in Enterobacteriaceae and Pseudomonas aeruginosa.

    Science.gov (United States)

    Tato, Marta; Coque, Teresa M; Baquero, Fernando; Cantón, Rafael

    2010-01-01

    The emergence of bla(VIM-1) within four different genetic platforms from distinct Enterobacteriaceae and Pseudomonas aeruginosa isolates in an area with a low prevalence of metallo-beta-lactamase producers is reported. Forty-three VIM-1-producing isolates (including 19 Enterobacter cloacae, 2 Escherichia coli, and 2 P. aeruginosa isolates, 18 Klebsiella pneumoniae isolate, and 2 Klebsiella oxytoca isolate) recovered from 2005 to 2007 and corresponding to 15 pulsed-field gel electrophoresis types were studied. The Enterobacteriaceae isolates corresponded to a hospital outbreak, and the P. aeruginosa isolates were sporadically recovered. The genetic context of the integrons carrying bla(VIM-1) (arbitrarily designated types A, B, C, and D) was characterized by PCR mapping based on known Tn402 and mercury transposons and further sequencing. Among Enterobacteriaceae isolates, bla(VIM-1) was part of integrons located either in an In2-Tn402 element linked to Tn21 (type A; In110-bla(VIM-1)-aacA4-aadA1) or in a Tn402 transposon lacking the whole tni module [type B; In113-bla(VIM-1)-aacA4-dhfrII (also called dfrB1)-aadA1-catB2] and the transposon was associated with an IncHI2 or IncI1 plasmid, respectively. Among P. aeruginosa isolates, bla(VIM-1) was part of a new gene cassette array located in a defective Tn402 transposon carrying either tniBDelta3 and tniA (type C; bla(VIM-1)-aadA1) or tniC and DeltatniQ (type D; bla(VIM-1)-aadB), and both Tn402 variants were associated with conjugative plasmids of 30 kb. The dissemination of bla(VIM-1) was associated with different genetic structures and bacterial hosts, depicting a complex emergence and evolutionary network scenario in our facility, Ramón y Cajal University Hospital, Madrid, Spain. Knowledge of the complex epidemiology of bla(VIM-1) is necessary to control this emerging threat. PMID:19901094

  15. Application of diffraction methods to materials control during processing procedures

    International Nuclear Information System (INIS)

    The application of diffraction analytical methods for the express-express acquisition of data on the materials structural states and determination of their technological characteristics is described. The application of the roentgenostructural analysis for determination of the carbon steel stamping ability, technological plasticity of the 40Kh steel by pressing, the TiN coating thickness on the 40Kh steel in the process of ion-plasma spraying, the perfection of texture in the alloys for the (Nd2Fe14B, SmCo5). The method for determining crystals orientation in turbine blades with the purpose of providing for suitable crystallographic orientation by production of items through the method of directed crystallization for improving their service life is described. The diffraction analytical methods are characterized in comparison to the traditional control methods by the same advantages, which are nondestructive ones, and specified by high expressivity

  16. Classification, processing and application of hydrogels: A review.

    Science.gov (United States)

    Ullah, Faheem; Othman, Muhammad Bisyrul Hafi; Javed, Fatima; Ahmad, Zulkifli; Md Akil, Hazizan

    2015-12-01

    This article aims to review the literature concerning the choice of selectivity for hydrogels based on classification, application and processing. Super porous hydrogels (SPHs) and superabsorbent polymers (SAPs) represent an innovative category of recent generation highlighted as an ideal mould system for the study of solution-dependent phenomena. Hydrogels, also termed as smart and/or hungry networks, are currently subject of considerable scientific research due to their potential in hi-tech applications in the biomedical, pharmaceutical, biotechnology, bioseparation, biosensor, agriculture, oil recovery and cosmetics fields. Smart hydrogels display a significant physiochemical change in response to small changes in the surroundings. However, such changes are reversible; therefore, the hydrogels are capable of returning to its initial state after a reaction as soon as the trigger is removed.

  17. Plasma process optimization for N-type doping applications

    Energy Technology Data Exchange (ETDEWEB)

    Raj, Deven; Persing, Harold; Salimian, Siamak; Lacey, Kerry; Qin Shu; Hu, Jeff Y.; McTeer, Allen [Applied Materials, Inc., Varian Semiconductor Business Unit, 35 Dory Road, Gloucester, MA 01930 (United States); Micron Technology, Inc., 8000 S. Federal Way, Boise, ID 83707 (United States)

    2012-11-06

    Plasma doping (PLAD) has been adopted across the implant technology space and into high volume production for both conventional DRAM and NAND doping applications. PLAD has established itself as an alternative to traditional ion implantation by beamline implantation. The push for high doping concentration, shallow doping depth, and conformal doping capability expand the need for a PLAD solution to meet such requirements. The unique doping profile and doping characteristics at high dose rates allow for PLAD to deliver a high throughput, differentiated solution to meet the demand of evolving transistor technology. In the PLAD process, ions are accelerated to the wafer as with a negative wafer bias applied to the wafer. Competing mechanisms, such as deposition, sputtering, and etching inherent in plasma doping require unique control and process optimization. In this work, we look at the distinctive process tool control and characterization features which enable an optimized doping process using n-type (PH{sub 3} or AsH{sub 3}) chemistries. The data in this paper will draw the relationship between process optimization through plasma chemistry study to the wafer level result.

  18. High Throughput Multispectral Image Processing with Applications in Food Science.

    Directory of Open Access Journals (Sweden)

    Panagiotis Tsakanikas

    Full Text Available Recently, machine vision is gaining attention in food science as well as in food industry concerning food quality assessment and monitoring. Into the framework of implementation of Process Analytical Technology (PAT in the food industry, image processing can be used not only in estimation and even prediction of food quality but also in detection of adulteration. Towards these applications on food science, we present here a novel methodology for automated image analysis of several kinds of food products e.g. meat, vanilla crème and table olives, so as to increase objectivity, data reproducibility, low cost information extraction and faster quality assessment, without human intervention. Image processing's outcome will be propagated to the downstream analysis. The developed multispectral image processing method is based on unsupervised machine learning approach (Gaussian Mixture Models and a novel unsupervised scheme of spectral band selection for segmentation process optimization. Through the evaluation we prove its efficiency and robustness against the currently available semi-manual software, showing that the developed method is a high throughput approach appropriate for massive data extraction from food samples.

  19. Plasma process optimization for N-type doping applications

    International Nuclear Information System (INIS)

    Plasma doping (PLAD) has been adopted across the implant technology space and into high volume production for both conventional DRAM and NAND doping applications. PLAD has established itself as an alternative to traditional ion implantation by beamline implantation. The push for high doping concentration, shallow doping depth, and conformal doping capability expand the need for a PLAD solution to meet such requirements. The unique doping profile and doping characteristics at high dose rates allow for PLAD to deliver a high throughput, differentiated solution to meet the demand of evolving transistor technology. In the PLAD process, ions are accelerated to the wafer as with a negative wafer bias applied to the wafer. Competing mechanisms, such as deposition, sputtering, and etching inherent in plasma doping require unique control and process optimization. In this work, we look at the distinctive process tool control and characterization features which enable an optimized doping process using n-type (PH3 or AsH3) chemistries. The data in this paper will draw the relationship between process optimization through plasma chemistry study to the wafer level result.

  20. High Throughput Multispectral Image Processing with Applications in Food Science.

    Science.gov (United States)

    Tsakanikas, Panagiotis; Pavlidis, Dimitris; Nychas, George-John

    2015-01-01

    Recently, machine vision is gaining attention in food science as well as in food industry concerning food quality assessment and monitoring. Into the framework of implementation of Process Analytical Technology (PAT) in the food industry, image processing can be used not only in estimation and even prediction of food quality but also in detection of adulteration. Towards these applications on food science, we present here a novel methodology for automated image analysis of several kinds of food products e.g. meat, vanilla crème and table olives, so as to increase objectivity, data reproducibility, low cost information extraction and faster quality assessment, without human intervention. Image processing's outcome will be propagated to the downstream analysis. The developed multispectral image processing method is based on unsupervised machine learning approach (Gaussian Mixture Models) and a novel unsupervised scheme of spectral band selection for segmentation process optimization. Through the evaluation we prove its efficiency and robustness against the currently available semi-manual software, showing that the developed method is a high throughput approach appropriate for massive data extraction from food samples.

  1. Application of ionizing radiation processing in biomedical engineering and microelectronics

    Energy Technology Data Exchange (ETDEWEB)

    Hongfej, H.; Jilan, W.

    1988-01-01

    The applied radiation chemistry has made great contributions to the development of polymeric industrial materials by the characteristics reaction means such as crosslinking, graft copolymerization and low-temperature or solid-phase polymerization, and become a important field on peaceful use of atomic energy. A brief review on the applications of ionizing radiation processing in biomedical engineering and microelectronics is presented. The examples of this technique were the studies on biocompatible and biofunctional polymers for medical use and on resists of lithography in microelectronics.

  2. Modelling and simulation of diffusive processes methods and applications

    CERN Document Server

    Basu, SK

    2014-01-01

    This book addresses the key issues in the modeling and simulation of diffusive processes from a wide spectrum of different applications across a broad range of disciplines. Features: discusses diffusion and molecular transport in living cells and suspended sediment in open channels; examines the modeling of peristaltic transport of nanofluids, and isotachophoretic separation of ionic samples in microfluidics; reviews thermal characterization of non-homogeneous media and scale-dependent porous dispersion resulting from velocity fluctuations; describes the modeling of nitrogen fate and transport

  3. Adhesives technology for electronic applications materials, processing, reliability

    CERN Document Server

    Licari, James J

    2011-01-01

    Adhesives are widely used in the manufacture and assembly of electronic circuits and products. Generally, electronics design engineers and manufacturing engineers are not well versed in adhesives, while adhesion chemists have a limited knowledge of electronics. This book bridges these knowledge gaps and is useful to both groups. The book includes chapters covering types of adhesive, the chemistry on which they are based, and their properties, applications, processes, specifications, and reliability. Coverage of toxicity, environmental impacts and the regulatory framework make this book par

  4. Advanced electrical and electronics materials processes and applications

    CERN Document Server

    Gupta, K M

    2015-01-01

    This comprehensive and unique book is intended to cover the vast and fast-growing field of electrical and electronic materials and their engineering in accordance with modern developments.   Basic and pre-requisite information has been included for easy transition to more complex topics. Latest developments in various fields of materials and their sciences/engineering, processing and applications have been included. Latest topics like PLZT, vacuum as insulator, fiber-optics, high temperature superconductors, smart materials, ferromagnetic semiconductors etc. are covered. Illustrations and exa

  5. 32 CFR 239.9 - Application Processing Procedures.

    Science.gov (United States)

    2010-07-01

    ...) Assignment of Application Numbers. (1) Assignment of Application Numbers. When a district receives an application, it will assign the application number and develop and maintain an individual file for each... withdrawn application does not require a new application or application number. (2) Method of Assignment....

  6. A software engineering process for safety-critical software application.

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Byung Heon; Kim, Hang Bae; Chang, Hoon Seon; Jeon, Jong Sun [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1995-02-01

    Application of computer software to safety-critical systems in on the increase. To be successful, the software must be designed and constructed to meet the functional and performance requirements of the system. For safety reason, the software must be demonstrated not only to meet these requirements, but also to operate safely as a component within the system. For longer-term cost consideration, the software must be designed and structured to ease future maintenance and modifications. This paper presents a software engineering process for the production of safety-critical software for a nuclear power plant. The presentation is expository in nature of a viable high quality safety-critical software development. It is based on the ideas of a rational design process and on the experience of the adaptation of such process in the production of the safety-critical software for the shutdown system number two of Wolsung 2, 3 and 4 nuclear power generation plants. This process is significantly different from a conventional process in terms of rigorous software development phases and software design techniques, The process covers documentation, design, verification and testing using mathematically precise notations and highly reviewable tabular format to specify software requirements and software requirements and software requirements and code against software design using static analysis. The software engineering process described in this paper applies the principle of information-hiding decomposition in software design using a modular design technique so that when a change is required or an error is detected, the affected scope can be readily and confidently located. it also facilitates a sense of high degree of confidence in the `correctness` of the software production, and provides a relatively simple and straightforward code implementation effort. 1 figs., 10 refs. (Author).

  7. Some novel concepts in radiation processing technology applications

    International Nuclear Information System (INIS)

    Search for better materials and processes has been a part of the evolution of mankind and it still continues to be so as it is being realized that earth's resources are not everlasting and effect of rapid growth on environment may adversely affect the future development. Sustainable development is the only choice for today for long term survival. Better quality and high functional materials, made by superior technologies are being demanded by the society. Radiation processing technology has significantly contributed to meet the expectation of the people in providing superior products and processes while preserving the environment. Processes are being developed where resources are fully utilized with maximum advantages and little disturbance to the environment. More than 1500 electron beam accelerators and about 500 Gamma Irradiators are presently in use and many are being deployed for radiation processing of medical supplies, pharmaceuticals and herbal materials, treat effluents and preserve food and agricultural products and several industrial products. DAE has an ambitious plan to deploy radiation technology for societal benefits in India. In the presentations some interesting applications of Radiation Processing Technology will be discussed which includes (1) Radiation Processing of Cashew Apple fruit for bio-ethanol production (2) High Energy Battery separators (3) Plant Growth Promoters and (4) Tunable biodegradability. The discussion would reveal how a waste product like cashew apple can be converted to useful materials and advanced materials like HEB separators and Tunable Biodegradable films can be made using radiation technology. Use of radiation de-polymerized polysaccharides in some experiments have shown unexpected increase in agriculture output giving new concepts to increase the productivity. (author)

  8. A software engineering process for safety-critical software application

    International Nuclear Information System (INIS)

    Application of computer software to safety-critical systems in on the increase. To be successful, the software must be designed and constructed to meet the functional and performance requirements of the system. For safety reason, the software must be demonstrated not only to meet these requirements, but also to operate safely as a component within the system. For longer-term cost consideration, the software must be designed and structured to ease future maintenance and modifications. This paper presents a software engineering process for the production of safety-critical software for a nuclear power plant. The presentation is expository in nature of a viable high quality safety-critical software development. It is based on the ideas of a rational design process and on the experience of the adaptation of such process in the production of the safety-critical software for the shutdown system number two of Wolsung 2, 3 and 4 nuclear power generation plants. This process is significantly different from a conventional process in terms of rigorous software development phases and software design techniques, The process covers documentation, design, verification and testing using mathematically precise notations and highly reviewable tabular format to specify software requirements and software requirements and software requirements and code against software design using static analysis. The software engineering process described in this paper applies the principle of information-hiding decomposition in software design using a modular design technique so that when a change is required or an error is detected, the affected scope can be readily and confidently located. it also facilitates a sense of high degree of confidence in the 'correctness' of the software production, and provides a relatively simple and straightforward code implementation effort. 1 figs., 10 refs. (Author)

  9. Advances in statistical monitoring of complex multivariate processes with applications in industrial process control

    CERN Document Server

    Kruger, Uwe

    2012-01-01

    The development and application of multivariate statistical techniques in process monitoring has gained substantial interest over the past two decades in academia and industry alike.  Initially developed for monitoring and fault diagnosis in complex systems, such techniques have been refined and applied in various engineering areas, for example mechanical and manufacturing, chemical, electrical and electronic, and power engineering.  The recipe for the tremendous interest in multivariate statistical techniques lies in its simplicity and adaptability for developing monitoring applica

  10. Applications of Natural Language Processing in Biodiversity Science

    Directory of Open Access Journals (Sweden)

    Anne E. Thessen

    2012-01-01

    A computer can handle the volume but cannot make sense of the language. This paper reviews and discusses the use of natural language processing (NLP and machine-learning algorithms to extract information from systematic literature. NLP algorithms have been used for decades, but require special development for application in the biological realm due to the special nature of the language. Many tools exist for biological information extraction (cellular processes, taxonomic names, and morphological characters, but none have been applied life wide and most still require testing and development. Progress has been made in developing algorithms for automated annotation of taxonomic text, identification of taxonomic names in text, and extraction of morphological character information from taxonomic descriptions. This manuscript will briefly discuss the key steps in applying information extraction tools to enhance biodiversity science.

  11. Application of multifractal wavelet analysis to spontaneous fermentation processes

    CERN Document Server

    Ibarra-Junquera, V; Escalante-Minakata, P; Rosu, H C

    2007-01-01

    An algorithm is presented here to get more detailed information, of mixed culture type, based exclusively on the biomass concentrations data for fermentation processes. The analysis is performed having available only the on-line measurements of the redox potential. It is a two-step procedure which includes an Artificial Neural Network (ANN) that relates the redox potential to the biomass concentrations in the first step. Next, a multifractal wavelet analysis is performed using the biomass estimates of the process. In this context, our results show that the redox potential is a valuable indicator of microorganism metabolic activity during the spontaneous fermentation. In this paper, the detailed design of the multifractal wavelet analysis is presented, as well as its direct experimental application at the laboratory level

  12. Materials and processes for spacecraft and high reliability applications

    CERN Document Server

    D Dunn, Barrie

    2016-01-01

    The objective of this book is to assist scientists and engineers select the ideal material or manufacturing process for particular applications; these could cover a wide range of fields, from light-weight structures to electronic hardware. The book will help in problem solving as it also presents more than 100 case studies and failure investigations from the space sector that can, by analogy, be applied to other industries. Difficult-to-find material data is included for reference. The sciences of metallic (primarily) and organic materials presented throughout the book demonstrate how they can be applied as an integral part of spacecraft product assurance schemes, which involve quality, material and processes evaluations, and the selection of mechanical and component parts. In this successor edition, which has been revised and updated, engineering problems associated with critical spacecraft hardware and the space environment are highlighted by over 500 illustrations including micrographs and fractographs. Sp...

  13. Application of Ion Beam Processing Technology in Production of Catalysts

    Directory of Open Access Journals (Sweden)

    Mykola G. Bannikov, Javed A. Chattha

    2012-08-01

    Full Text Available In this paper, the applicability of Ion Beam Processing Technology for making catalysts has been inves-tigated. Ceramic substrates of different shapes and metal fibre tablets were implanted by platinum ions and tested in nitrogen oxides (NOx and carbon monoxide (CO conversion reactions. Effectiveness of the implanted catalysts was compared to that of the commercially produced platinum catalysts made by impregnation. Platinum-implanted catalyst having fifteen times less platinum content showed the same CO conversion efficiency as the commercially pro-duced catalyst. It was revealed that the effectiveness of the platinum-implanted catalyst has complex dependence on the process parameters and the optimum can be achieved by varying the ions energy and the duration of implantation. Investigation of the pore structure showed that ion implantation did not decrease the specific surface area of the catalyst.Key Words: Catalyst, Ion Implantation, Noble metals.

  14. High temperature reactor and application to nuclear process heat

    International Nuclear Information System (INIS)

    The principle of high temperature nuclear process heat is explained and the main applications (hydrogasification of coal, nuclear chemical heat pipe, direct reduction of iron ore, coal gasification by steam and water splitting) are described in more detail. The motivation for the introduction of nuclear process heat to the market, questions of cost, of raw material resources and environmental aspects are the next point of discussion. The new technological questions of the nuclear reactor and the status of development are described, especially information about the fuel elements, the hot gas ducts, the contamination and some design considerations are added. Furthermore the status of development of helium heated steam reformers, the main results of the work until now and the further activities in this field are explained. (author)

  15. Application of pulse combustion technology in spray drying process

    Directory of Open Access Journals (Sweden)

    I. Zbicinski

    2000-12-01

    Full Text Available The paper presents development of valved pulse combustor designed for application in drying process and drying tests performed in a specially built installation. Laser technique was applied to investigate the flow field and structure of dispersed phase during pulse combustion spray drying process. PDA technique was used to determine initial atomization parameters as well as particle size distribution, velocity of the particles, mass concentration of liquid phase in the cross section of spray stream, etc., in the drying chamber during drying tests. Water was used to estimate the level of evaporation and 5 and 10% solutions of sodium chloride to carry out drying tests. The Computational Fluid Dynamics technique was used to perform theoretical predictions of time-dependent velocity, temperature distribution and particle trajectories in the drying chamber. Satisfactory agreement between calculations and experimental results was found in certain regions of the drying chamber.

  16. Microcomputer Applications and the Electronic Office. Information Processing in the Electronic Office. Part 2: Applications.

    Science.gov (United States)

    Business Education World, 1986

    1986-01-01

    Various elements of microcomputer technology are examined: word processing, microcomputer applications in school curricula, and communications. The author also discusses ethical use of software, the importance of teaching students procedures for good records management, and a view of the "office of the future." (CT)

  17. Melt processing of bulk high Tc superconductors and their application

    Science.gov (United States)

    Murakami, M.; Oyama, T.; Fujimoto, H.; Gotoh, S.; Yamaguchi, K.

    1991-03-01

    The authors report a melt-powder-melt-growth (MPMG) process which results in high Jc for bulk Y-Ba-Cu-O superconductors. The Y-Ba-Cu-O pellets or powders are melt quenched. The quenched plates are crushed into powder and mixed well. The powder is then compacted into desired shapes, remelted, and slowly cooled in a thermal gradient. When the starting composition is changed from the 1:2:3 stoichiometry toward the Y2BaCuO5(211) rich region, the 211 inclusions can be dispersed in the YBa2Cu3O(x) matrix, which contributes to increases in both flux pinning force and fracture toughness. A Jc value exceeding 3 x 108 A/sq m has been achieved at 77 K and 1 T. Another attractive feature of the MPMG process is that other components such as fine Ag powders can be added during solid-state mixing. Fine dispersion of Ag particles can effectively reduce the amount of cracking. MPMG-processed Y-Ba-Cu-O with Ag doping can levitate a mass of 3-kg at 1-mm height using a repulsive force against a 0.4-T magnet. A noncontacting rotation device such as a magnetic bearing can be made utilizing bulk high-Jc materials. A superconducting permanent magnet is also a promising candidate for future application. MPMG-processed Y-Ba-Cu-O can generate 0.25 T at 77 K.

  18. Moving bed biofilm reactor technology: process applications, design, and performance.

    Science.gov (United States)

    McQuarrie, James P; Boltz, Joshua P

    2011-06-01

    The moving bed biofilm reactor (MBBR) can operate as a 2- (anoxic) or 3-(aerobic) phase system with buoyant free-moving plastic biofilm carriers. These systems can be used for municipal and industrial wastewater treatment, aquaculture, potable water denitrification, and, in roughing, secondary, tertiary, and sidestream applications. The system includes a submerged biofilm reactor and liquid-solids separation unit. The MBBR process benefits include the following: (1) capacity to meet treatment objectives similar to activated sludge systems with respect to carbon-oxidation and nitrogen removal, but requires a smaller tank volume than a clarifier-coupled activated sludge system; (2) biomass retention is clarifier-independent and solids loading to the liquid-solids separation unit is reduced significantly when compared with activated sludge systems; (3) the MBBR is a continuous-flow process that does not require a special operational cycle for biofilm thickness, L(F), control (e.g., biologically active filter backwashing); and (4) liquid-solids separation can be achieved with a variety of processes, including conventional and compact high-rate processes. Information related to system design is fragmented and poorly documented. This paper seeks to address this issue by summarizing state-of-the art MBBR design procedures and providing the reader with an overview of some commercially available systems and their components. PMID:21751715

  19. Moving bed biofilm reactor technology: process applications, design, and performance.

    Science.gov (United States)

    McQuarrie, James P; Boltz, Joshua P

    2011-06-01

    The moving bed biofilm reactor (MBBR) can operate as a 2- (anoxic) or 3-(aerobic) phase system with buoyant free-moving plastic biofilm carriers. These systems can be used for municipal and industrial wastewater treatment, aquaculture, potable water denitrification, and, in roughing, secondary, tertiary, and sidestream applications. The system includes a submerged biofilm reactor and liquid-solids separation unit. The MBBR process benefits include the following: (1) capacity to meet treatment objectives similar to activated sludge systems with respect to carbon-oxidation and nitrogen removal, but requires a smaller tank volume than a clarifier-coupled activated sludge system; (2) biomass retention is clarifier-independent and solids loading to the liquid-solids separation unit is reduced significantly when compared with activated sludge systems; (3) the MBBR is a continuous-flow process that does not require a special operational cycle for biofilm thickness, L(F), control (e.g., biologically active filter backwashing); and (4) liquid-solids separation can be achieved with a variety of processes, including conventional and compact high-rate processes. Information related to system design is fragmented and poorly documented. This paper seeks to address this issue by summarizing state-of-the art MBBR design procedures and providing the reader with an overview of some commercially available systems and their components.

  20. UNICOS CPC6: Automated Code Generation for Process Control Applications

    CERN Document Server

    Fernandez Adiego, B; Prieto Barreiro, I

    2011-01-01

    The Continuous Process Control package (CPC) is one of the components of the CERN Unified Industrial Control System framework (UNICOS) [1]. As a part of this framework, UNICOS-CPC provides a well defined library of device types, amethodology and a set of tools to design and implement industrial control applications. The new CPC version uses the software factory UNICOS Application Builder (UAB) [2] to develop CPC applications. The CPC component is composed of several platform oriented plugins PLCs and SCADA) describing the structure and the format of the generated code. It uses a resource package where both, the library of device types and the generated file syntax, are defined. The UAB core is the generic part of this software, it discovers and calls dynamically the different plug-ins and provides the required common services. In this paper the UNICOS CPC6 package is introduced. It is composed of several plug-ins: the Instance generator and the Logic generator for both, Siemens and Schneider PLCs, the SCADA g...

  1. A Magnetic Induction Tomography System for Prospective Industrial Processing Applications

    Institute of Scientific and Technical Information of China (English)

    Hsin-Yu Wei; Manuchehr Solelmanl

    2012-01-01

    Magnetic induction tomography(MIT) is one of the newest industrial process imaging techniques.Main industrial applications of the MIT imaging are in high conductive flow imaging.However,recently it has been shown that the MIT may be useful for low conductive process imaging.This paper presents a cost effective hardware design for MIT in industrial applications,called Bath-MKI industrial MIT system.The system comprises 8 inductor coils and has the possibility of expansion to 16 coils.The excitation signals and the measured voltages are generated and measured using a LabView based system.Two 16 by 1 multiplexers are used to select between the coils.Measurements,excitation and multiplexing are all controlled by a National Instrument(NI) USB based DAQ:USB-6259 and a signal generator.Using the same electronics,the prototype is tested with two different coil arrays;one is a small scale ferrite core coil and one larger scale air cored coil.Experimental image reconstruction results are shown using both small scale and large scale coil arrays.

  2. Optimization of polyetherimide processing parameters for optical interconnect applications

    Science.gov (United States)

    Zhao, Wei; Johnson, Peter; Wall, Christopher

    2015-10-01

    ULTEM® polyetherimide (PEI) resins have been used in opto-electronic markets since the optical properties of these materials enable the design of critical components under tight tolerances. PEI resins are the material of choice for injection molded integrated lens applications due to good dimensional stability, near infrared (IR) optical transparency, low moisture uptake and high heat performance. In most applications, parts must be produced consistently with minimal deviations to insure compatibility throughout the lifetime of the part. With the large number of lenses needed for this market, injection molding has been optimized to maximize the production rate. These optimized parameters for high throughput may or may not translate to an optimized optical performance. In this paper, we evaluate and optimize PEI injection molding processes with a focus on optical property performance. A commonly used commercial grade was studied to determine factors and conditions which contribute to optical transparency, color, and birefringence. Melt temperature, mold temperature, injection speed and cycle time were varied to develop optimization trials and evaluate optical properties. These parameters could be optimized to reduce in-plane birefringence from 0.0148 to 0.0006 in this study. In addition, we have studied an optically smooth, sub-10nm roughness mold to re-evaluate material properties with minimal influence from mold quality and further refine resin and process effects for the best optical performance.

  3. MeV ion processing applications for industry

    International Nuclear Information System (INIS)

    Ions beams with MeV energies produce a variety of interactions with matter, broadly classified as either electronic or nuclear. These interactions in turn lead to changes in the properties of the matter which may be beneficial or detrimental. In high technology industry, use is increasingly made of ion beam technologies to process novel materials. Typical applications include high energy implantation, in which the deposition of a specific element at depth within the structure of material is the required objective, and irradiation modification, in which the balance between the beneficial and the detrimental effects of the fast ion interactions is exploited. The basic principles behind MeV ion processing are described. Broad areas of application in industrial materials include effects in ion beam analysis, Thin Layer Activation for wear and corrosion measurement, carrier lifetime control in electronic devices, and the simulation of radiation damage effects in, for example, solar cells for spacecraft. New development areas are described in which subtle but potentially significant changes in the chemistry of surfaces and interfaces may be generated by exposure to MeV ion beams. (orig.)

  4. Modelling of transport processes in porous media for energy applications

    Energy Technology Data Exchange (ETDEWEB)

    Kangas, M.

    1996-12-31

    Flows in porous media are encountered in many branches of technology. In these phenomena, a fluid of some sort is flowing through porous matrix of a solid medium. Examples of the fluid are water, air, gas and oil. The solid matrix can be soil, fissured rock, ceramics, filter paper, etc. The flow is in many cases accompanied by transfer of heat or solute within the fluid or between the fluid and the surrounding solid matrix. Chemical reactions or microbiological processes may also be taking place in the system. In this thesis, a 3-dimensional computer simulation model THETA for the coupled transport of fluid, heat, and solute in porous media has been developed and applied to various problems in the field of energy research. Although also applicable to porous medium applications in general, the version of the model described and used in this work is intended for studying the transport processes in aquifers, which are geological formations containing groundwater. The model highlights include versatile input and output routines, as well as modularity which, for example, enables an easy adaptation of the model for use as a subroutine in large energy system simulations. Special attention in the model development has been attached to high flow conditions, which may be present in Nordic esker aquifers located close to the ground surface. The simulation model has been written with FORTRAN 77 programming language, enabling a seamless operation both in PC and main frame environments. For PC simulation, a special graphic user interface has been developed. The model has been used with success in a wide variety of applications, ranging from basic thermal analyses to thermal energy storage system evaluations and nuclear waste disposal simulations. The studies have shown that thermal energy storage is feasible also in Nordic high flow aquifers, although at the cost of lower recovery temperature level, usually necessitating the use of heat pumps. In the nuclear waste studies, it

  5. Exploitation of Information Processing Technologies to Extend Digital Library Applications

    Directory of Open Access Journals (Sweden)

    Jian-Hua Yeh、Jia-Yanh Chang、Yen-Jen Oyan

    1999-04-01

    Full Text Available

    頁次:1-11

    This paper discusses exploitation of information processing technologies to extend digital library applications to a new dimension. The discussion focuses on the following three information processing technologies.

    l. information extraction.

    2. deductive inference.

    3. data mining.

    The most significant applications are discovery and derivation of new information and knowledge. This paper discusses how these information processing technologies can be exploited to complement the capabilities of human beings in the digital library domain. The tasks that the developed information processing utilities perform are simple and tedious intelligent information processing. However, because a digital library contains a large quantity of contents, it is common that human beings can hardly carry out such tasks exhaustively. As a result, a great amount of information and knowledge may remain undiscovered without the assistance of assistance of such utilities. On the other hands, with the developed information processing utilities, human being are the released form performing

  6. Metabolic processes of Methanococcus maripaludis and potential applications.

    Science.gov (United States)

    Goyal, Nishu; Zhou, Zhi; Karimi, Iftekhar A

    2016-01-01

    Methanococcus maripaludis is a rapidly growing, fully sequenced, genetically tractable model organism among hydrogenotrophic methanogens. It has the ability to convert CO2 and H2 into a useful cleaner energy fuel (CH4). In fact, this conversion enhances in the presence of free nitrogen as the sole nitrogen source due to prolonged cell growth. Given the global importance of GHG emissions and climate change, diazotrophy can be attractive for carbon capture and utilization applications from appropriately treated flue gases, where surplus hydrogen is available from renewable electricity sources. In addition, M. maripaludis can be engineered to produce other useful products such as terpenoids, hydrogen, methanol, etc. M. maripaludis with its unique abilities has the potential to be a workhorse like Escherichia coli and S. cerevisiae for fundamental and experimental biotechnology studies. More than 100 experimental studies have explored different specific aspects of the biochemistry and genetics of CO2 and N2 fixation by M. maripaludis. Its genome-scale metabolic model (iMM518) also exists to study genetic perturbations and complex biological interactions. However, a comprehensive review describing its cell structure, metabolic processes, and methanogenesis is still lacking in the literature. This review fills this crucial gap. Specifically, it integrates distributed information from the literature to provide a complete and detailed view for metabolic processes such as acetyl-CoA synthesis, pyruvate synthesis, glycolysis/gluconeogenesis, reductive tricarboxylic acid (RTCA) cycle, non-oxidative pentose phosphate pathway (NOPPP), nitrogen metabolism, amino acid metabolism, and nucleotide biosynthesis. It discusses energy production via methanogenesis and its relation to metabolism. Furthermore, it reviews taxonomy, cell structure, culture/storage conditions, molecular biology tools, genome-scale models, and potential industrial and environmental applications. Through the

  7. Radiation processing applications in the Czechoslovak water treatment technologies

    Science.gov (United States)

    Vacek, K.; Pastuszek, F.; Sedláček, M.

    The regeneration of biologically clogged water wells by radiation proved to be a successful and economically beneficial process among other promising applications of ionizing radiation in the water supply technology. The application conditions and experience are mentioned. The potential pathogenic Mycobacteria occuring in the warm washing and bathing water are resistant against usual chlorine and ozone concentrations. The radiation sensitivity of Mycobacteria allowed to suggest a device for their destroying by radiation. Some toxic substances in the underground water can be efficiently degraded by gamma radiation directly in the wells drilled as a hydraulic barrier surrounding the contaminated land area. Substantial decrease of CN - concentration and C.O.D. value was observed in water pumped from such well equipped with cobalt sources and charcoal. The removing of pathogenic contamination remains to be the main goal of radiation processing in the water purification technologies. The decrease of liquid sludge specific filter resistance and sedimentation acceleration by irradiation have a minor technological importance. The hygienization of sludge cake from the mechanical belt filter press by electron beam appears to be the optimum application in the Czechoslovak conditions. The potatoes and barley crop yields from experimental plots treated with sludge were higher in comparison with using the manure. Biological sludge from the municipal and food industry water purification plants contains nutritive components. The proper hygienization is a necessary condition for using them as a livestock feed supplement. Feeding experiments with broilers and pigs confirmed the possibility of partial (e.g. 50%) replacement of soya-, bone- or fish flour in feed mixtures by dried sludge hygienized either by heat or by the irradiation.

  8. Radiation processing applications in the Czechoslovak water treatment technologies

    International Nuclear Information System (INIS)

    The regeneration of biologically clogged water wells by radiation proved to be a successful and economically beneficial process among other promising applications of ionizing radiation in the water supply technology. The application conditions and experience are mentioned. The potential pathogenic Mycobacteria occuring in the warm washing and bathing water are resistant against usual chlorine and ozone concentrations. The radiation sensitivity of Mycobacteria allowed to suggest a device for their destroying by radiation. Some toxic substances in the underground water can be efficiently degraded by gamma radiation directly in the wells drilled as a hydraulic barrier surrounding the contaminated land area. Substantial decrease of CN- concentration and C.O.D. value was observed in water pumped from such well equipped with cobalt sources and charcoal. The removing of pathogenic contamination remains to be the main goal of radiation processing in the water purification technologies. The decrease of liquid sludge specific filter resistance and sedimentation acceleration by irradiation have a minor technological importance. The hygienization of sludge cake from the mechanical belt filter press by electron beam appears to be the optimum application in the Czechoslovak conditions. The potatoes and barley crop yields from experimental plots treated with sludge were higher in comparison with using the manure. Biological sludge from the municipal and food industry water purification plants contains nutritive components. The proper hygienization is a necessary condition for using them as a livestock feed supplement. Feeding experiments with broilers and pigs confirmed the possibility of partial (e.g. 50%) replacement of soya-, bone, or fish flour in feed mixtures by dried sludge hygienized either by heat or by the irradiation. (author)

  9. Input-specific contributions to valence processing in the amygdala.

    Science.gov (United States)

    Correia, Susana S; Goosens, Ki A

    2016-10-01

    Reward and punishment are often thought of as opposing processes: rewards and the environmental cues that predict them elicit approach and consummatory behaviors, while punishments drive aversion and avoidance behaviors. This framework suggests that there may be segregated brain circuits for these valenced behaviors. The basolateral amygdala (BLA) is one brain region that contributes to both types of motivated behavior. Individual neurons in the BLA can favor positive over negative valence, or vice versa, but these neurons are intermingled, showing no anatomical segregation. The amygdala receives inputs from many brain areas and current theories posit that encoding of positive versus negative valence by BLA neurons is determined by the wiring of each neuron. Specifically, many projections from other brain areas that respond to positive and negative valence stimuli and predictive cues project strongly to the BLA and likely contribute to valence processing within the BLA. Here we review three of these areas, the basal forebrain, the dorsal raphe nucleus and the ventral tegmental area, and discuss how these may promote encoding of positive and negative valence within the BLA. PMID:27634144

  10. Whole-animal imaging of bacterial infection using endoscopic excitation of β-lactamase (BlaC)-specific fluorogenic probe

    Science.gov (United States)

    Nooshabadi, Fatemeh; Yang, Hee-Jeong; Cheng, Yunfeng; Xie, Hexin; Rao, Jianghong; Cirillo, Jeffrey D.; Maitland, Kristen C.

    2016-03-01

    Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the most frequent causes of death worldwide. The slow growth rate of Mtb limits progress toward understanding tuberculosis including diagnosis of infections and evaluating therapeutic efficacy. Development of near-infrared (NIR) β-lactamase (BlaC)-specific fluorogenic substrate has made a significant breakthrough in the whole-animal imaging to detect Mtb infection. The reporter enzyme fluorescence (REF) system using a BlaC-specific fluorogenic substrate has improved the detection sensitivity in whole-animal optical imaging down to ~104 colony forming units (CFU) of bacteria, about 100-fold improvement over recombinant strains. However, improvement of detection sensitivity is strongly needed for clinical diagnosis of early stage infection at greater tissue depth. In order to improve detection sensitivity, we have integrated a fiber-based microendoscpe into a whole-animal imaging system to transmit the excitation light from the fiber bundle to the fluorescent target directly and measure fluorescent level using BlaC-specific REF substrate in the mouse lung. REF substrate, CNIR800, was delivered via aerosol route to the pulmonary infected mice with M. bovis BCG strain at 24 hours post-infection and groups of mice were imaged at 1-4 hours post-administration of the substrate using the integrated imaging system. In this study we evaluated the kinetics of CNIR800 substrate using REF technology using the integrated imaging system. Integration of these technologies has great promise for improved detection sensitivity allowing pre-clinical imaging for evaluation of new therapeutic agents.

  11. Emerging Carbapenem-Resistant Pseudomonas aeruginosa Isolates Carrying blaIMP Among Burn Patients in Isfahan, Iran

    Science.gov (United States)

    Radan, Mohsen; Moniri, Rezvan; Khorshidi, Ahmad; Gilasi, Hamidreza; Norouzi, Zohreh; Beigi, Fahimeh; Dasteh Goli, Yasaman

    2016-01-01

    Background Metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa is a significant pathogen in burn patients. Objectives The aim of this study was to determine the prevalence of carbapenem-resistant P. aeruginosa isolates, including those resistant to imipenemase (IMP), in a burn unit in Isfahan, Iran. Patients and Methods One hundred and fifty P. aeruginosa isolates from burn patients were tested for antibiotic susceptibility by the disc diffusion method in accordance with CLSI guidelines. Production of MBL was identified with the EDTA disk method. DNA was purified from the MBL-positive isolates, and detection of the blaIMP gene was performed with PCR. Results Fifty-seven out of 150 (38%) isolates were multi-drug resistant (MDR), and 93 (62%) were extensively-drug resistant (XDR). Among all isolates, the resistance rate to ciprofloxacin, tobramycin, imipenem, meropenem, amikacin, ceftazidime, and cefepime was higher than 90%, while the resistance rates to piperacillin/tazobactam and aztreonam were 70.7% and 86%, respectively. Colistin and polymyxin B remained the most effective studied antibiotics. All of the imipenem-resistant P. aeruginosa isolates were MBL-positive, and 107 out of 144 (74.3%) of the MBL isolates were positive for the blaIMP gene. Conclusions The results of this study show that the rate of P. aeruginosa-caused burn wound infections was very high, and many of the isolates were resistant to three or more classes of antimicrobials. Such extensive resistance to antimicrobial classes is important because few treatment options remain for patients with burn wound infections. blaIMP-producing P. aeruginosa isolates are a rising threat in burn-care units, and should be controlled by conducting infection-control assessments.

  12. Flexible organic electronic devices: Materials, process and applications

    Energy Technology Data Exchange (ETDEWEB)

    Logothetidis, Stergios [Laboratory for Thin Films-Nanosystems and Nanometrology, Department of Physics, Aristotle University of Thessaloniki, Thessaloniki 54 124 (Greece)], E-mail: logot@auth.gr

    2008-08-25

    The research for the development of flexible organic electronic devices (FEDs) is rapidly increasing worldwide, since FEDs will change radically several aspects of everyday life. Although there has been considerable progress in the area of flexible inorganic devices (a-Si or solution processed Si), there are numerous advances in the organic (semiconducting, conducting and insulating), inorganic and hybrid (organic-inorganic) materials that exhibit customized properties and stability, and in the synthesis and preparation methods, which are characterized by a significant amount of multidisciplinary efforts. Furthermore, the development and encapsulation of organic electronic devices onto flexible polymeric substrates by large-scale and low-cost roll-to-roll production processes will allow their market implementation in numerous application areas, including displays, lighting, photovoltaics, radio-frequency identification circuitry and chemical sensors, as well as to a new generation of modern exotic applications. In this work, we report on some of the latest advances in the fields of polymeric substrates, hybrid barrier layers, inorganic and organic materials to be used as novel active and functional thin films and nanomaterials as well as for the encapsulation of the materials components for the production of FEDs (flexible organic light-emitting diodes, and organic photovoltaics). Moreover, we will emphasize on the real-time optical monitoring and characterization of the growing films onto the flexible polymeric substrates by spectroscopic ellipsometry methods. Finally, the potentiality for the in-line characterization processes for the development of organic electronics materials will be emphasized, since it will also establish the framework for the achievement of the future scientific and technological breakthroughs.

  13. Ambiente genético del Gen blaCTX-M-12 en aislamientos hospitalarios de Klebsiella pneumoniae

    OpenAIRE

    Yamile Adriana Celis Bustos; Ingrid Yamile Pulido Manrique; Emilia María Valenzuela de Silva; María Teresa Reguero Reza; José Ramón Mantilla Anaya

    2009-01-01

    The blaCTX-M-12 gene’s genetic environmnt in Klebsiella pneumoniae hospital isolates Resumen: En Colombia se han detectado genes del grupo CTX-M-1 con alta frecuencia en aislamientos de Klebsiella pneumoniae causantes de infección intrahospitalaria. El conocimiento de los factores genéticos que pueden favorecer la diseminación de estos genes entre especies bacterianas es un aspecto importante para el control de la resistencia. En este estudio se identificaron los plásmidos portadores del ge...

  14. Draft Genome Sequence of a Multidrug-Resistant blaNDM-1-Producing Acinetobacter soli Isolate in China

    OpenAIRE

    Chen, Yan; Yan, Zhengsong; Wang, Miaojuan; Zheng, Xia; Lu, Yun; Lin, Shaohua

    2014-01-01

    Acinetobacter spp. are one of the most prevalent opportunistic pathogens causing nosocomial infections and have become a major clinical and public health threat. In this study, we presented the first draft genome sequence of A. soli TCM341, a multidrug resistant isolate that carried the blaNDM-1 gene in China. Genome sequencing of A. soli TCM341 was carried out in Illumina Hiseq 2000 next-generation sequencer. The data obtained revealed 74 contigs with genome size of 3.49 Mb and G+C content o...

  15. Draft genome sequence of a multidrug-resistant blaOXA-23-producing Acinetobacter baumannii ST208 isolate from China.

    Science.gov (United States)

    Chen, Yan; Wu, Liyan; Chen, Yu; Xu, Zhijun; Xu, Liqun

    2016-03-01

    Acinetobacter baumannii has emerged worldwide as an important opportunistic nosocomial pathogen and has become a major public health concern. In this study, the draft genome sequence of A. baumannii TCM331 (ST208/CC92), a multidrug-resistant (MDR) isolate harbouring the blaOXA-23 gene isolated in China, was determined. The genome of TCM331 was sequenced via Illumina HiSeq™ 2000, and bioinformatics analysis was performed. Important antimicrobial resistance determinants were observed in an estimated genome size of 4,058,691bp with 3838 predicted coding regions. In conclusion, these data might facilitate further understanding of the specific genomic features of MDR A. baumannii in China.

  16. Application of statistical process control to qualitative molecular diagnostic assays.

    Directory of Open Access Journals (Sweden)

    Cathal P O'brien

    2014-11-01

    Full Text Available Modern pathology laboratories and in particular high throughput laboratories such as clinical chemistry have developed a reliable system for statistical process control. Such a system is absent from the majority of molecular laboratories and where present is confined to quantitative assays. As the inability to apply statistical process control to assay is an obvious disadvantage this study aimed to solve this problem by using a frequency estimate coupled with a confidence interval calculation to detect deviations from an expected mutation frequency. The results of this study demonstrate the strengths and weaknesses of this approach and highlight minimum sample number requirements. Notably, assays with low mutation frequencies and detection of small deviations from an expected value require greater samples with a resultant protracted time to detection. Modelled laboratory data was also used to highlight how this approach might be applied in a routine molecular laboratory. This article is the first to describe the application of statistical process control to qualitative laboratory data.

  17. Improving Packet Processing Performance of a Memory-Bounded Application

    CERN Document Server

    Schumacher, Jorn; The ATLAS collaboration; Borga, Andrea; Boterenbrood, Hendrik; Chen, Hucheng; Chen, Kai; Drake, Gary; Francis, David; Gorini, Benedetto; Lanni, Francesco; Lehmann Miotto, Giovanna; Levinson, Lorne; Narevicius, Julia; Roich, Alexander; Ryu, Soo; Schreuder, Frans Philip; Vandelli, Wainer; Zhang, Jinlong; Vermeulen, Jos

    2015-01-01

    Experiments in high-energy physics (HEP) and related fields often impose constraints and challenges on data acquisition systems. As a result, these systems are implemented as unique mixtures of custom and commercial-off-the-shelf electronics (COTS), involving and connecting radiation-hard devices, large high-performance networks, and computing farms. FELIX, the Frontend Link Exchange, is a new PC-based general purpose data routing device for the data-acquisition system of the ATLAS experiment at CERN. Performance is a very crucial point for devices like FELIX, which have to be capable of processing tens of gigabyte of data per second. Thus it is important to understand the performance limitations for typical workloads on modern hardware. We present an analysis of a packet processing algorithm that is used in FELIX, and show how the PC system's memory architecture plays a key factor in the overall data throughput achieved by the application. Finally, we present optimizations that increase the processing throug...

  18. Scaling limits for Hawkes processes and application to financial statistics

    CERN Document Server

    Bacry, Emmanuel; Hoffmann, Marc; Muzy, Jean François

    2012-01-01

    We prove a law of large numbers and a functional central limit theorem for multivariate Hawkes processes observed over a time interval $[0,T]$ in the limit $T \\rightarrow \\infty$. We further exhibit the asymptotic behaviour of the covariation of the increments of the components of a multivariate Hawkes process, when the observations are imposed by a discrete scheme with mesh $\\Delta$ over $[0,T]$ up to some further time shift $\\tau$. The behaviour of this functional depends on the relative size of $\\Delta$ and $\\tau$ with respect to $T$ and enables to give a full account of the second-order structure. As an application, we develop our results in the context of financial statistics. We introduced in a previous work a microscopic stochastic model for the variations of a multivariate financial asset, based on Hawkes processes and that is confined to live on a tick grid. We derive and characterise the exact macroscopic diffusion limit of this model and show in particular its ability to reproduce important empiric...

  19. On Markovian traffic with applications to TES processes

    Directory of Open Access Journals (Sweden)

    David L. Jagerman

    1994-01-01

    Full Text Available Markov processes are an important ingredient in a variety of stochastic applications. Notable instances include queueing systems and traffic processes offered to them. This paper is concerned with Markovian traffic, i.e., traffic processes whose inter-arrival times (separating the time points of discrete arrivals form a real-valued Markov chain. As such this paper aims to extend the classical results of renewal traffic, where interarrival times are assumed to be independent, identically distributed. Following traditional renewal theory, three functions are addressed: the probability of the number of arrivals in a given interval, the corresponding mean number, and the probability of the times of future arrivals. The paper derives integral equations for these functions in the transform domain. These are then specialized to a subclass, TES+, of a versatile class of random sequences, called TES (Transform-Expand-Sample, consisting of marginally uniform autoregressive schemes with modulo-1 reduction, followed by various transformations. TES models are designed to simultaneously capture both first-order and second-order statistics of empirical records, and consequently can produce high-fidelity models. Two theoretical solutions for TES+ traffic functions are derived: an operator-based solution and a matric solution, both in the transform domain. A special case, permitting the conversion of the integral equations to differential equations, is illustrated and solved. Finally, the results are applied to obtain instructive closed-form representations for two measures of traffic burstiness: peakedness and index of dispersion, elucidating the relationship between them.

  20. Complete Nucleotide Sequence of IncP-1β Plasmid pDTC28 Reveals a Non-Functional Variant of the blaGES-Type Gene.

    Science.gov (United States)

    Dang, Bingjun; Mao, Daqing; Luo, Yi

    2016-01-01

    Plasmid pDTC28 was isolated from the sediments of Haihe River using E. coli CV601 (gfp-tagged) as recipient and indigenous bacteria from the sediment as donors. This plasmid confers reduced susceptibility to tetracycline and sulfamethoxazole. The complete sequence of plasmid pDTC28 was 61,503 bp in length with an average G+C content of 64.09%. Plasmid pDTC28 belongs to the IncP-1β group by phylogenetic analysis. The backbones of plasmid pDTC28 and other IncP-1β plasmids are very classical and conserved, whereas the accessory regions of these plasmids are diverse. A blaGES-5-like gene was found on the accessory region, and this blaGES-5-like gene contained 18 silent mutations and 7 missense mutations compared with the blaGES-5 gene. The mutations resulted in 7 amino acid substitutions in GES-5 carbapenemase, causing the loss of function of the blaGES-5-like gene on plasmid pDTC28 against carbapenems and even β-lactams. The enzyme produced by the blaGES-5-like gene cassette may be a new variant of GES-type enzymes. Thus, the plasmid sequenced in this study will expand our understanding of GES-type β-lactamases and provide insights into the genetic platforms used for the dissemination of GES-type genes. PMID:27152950

  1. Exploring the potential reservoirs of non specific TEM beta lactamase (blaTEM) gene in the Indo-Gangetic region: A risk assessment approach to predict health hazards.

    Science.gov (United States)

    Singh, Gulshan; Vajpayee, Poornima; Rani, Neetika; Amoah, Isaac Dennis; Stenström, Thor Axel; Shanker, Rishi

    2016-08-15

    The emergence of antimicrobial resistant bacteria is an important public health and environmental contamination issue. Antimicrobials of β-lactam group accounts for approximately two thirds, by weight, of all antimicrobials administered to humans due to high clinical efficacy and low toxicity. This study explores β-lactam resistance determinant gene (blaTEM) as emerging contaminant in Indo-Gangetic region using qPCR in molecular beacon format. Quantitative Microbial Risk Assessment (QMRA) approach was adopted to predict risk to human health associated with consumption/exposure of surface water, potable water and street foods contaminated with bacteria having blaTEM gene. It was observed that surface water and sediments of the river Ganga and Gomti showed high numbers of blaTEM gene copies and varied significantly (privers had high load of blaTEM gene copies. The information on prevalence of environmental reservoirs of blaTEM gene containing bacteria in Indo-Gangetic region and risk associated will be useful for formulating strategies to protect public from menace of clinical risks linked with antimicrobial resistant bacteria. PMID:27111425

  2. Encyclopedia of the Elements: Technical Data - History - Processing - Applications

    Science.gov (United States)

    Enghag, Per

    2004-09-01

    Famous for its history of numerous element discoverers, Sweden is the origin of this comprehensive encyclopedia of the elements. It provides both an important database for professionals as well as detailed reading ranging from historical facts, discoverers' portraits, color plates of mineral types, natural occurrences, and industrial figures right up to winning and refining processes, biological roles and applications in modern chemistry, engineering and industry. Elemental data is presented in fact tables that include numerous physical and thermodynamic properties, isotope lists, radiation absorption characteristics, NMR parameters, and others. Further pertinent data is supplied in additional tables throughout the text. Originally published in Swedish in three volumes from 1998 to 2000, the contents have been revised and expanded by the author for this English edition.

  3. The application of microwaves in essential oil hydrodistillation processes

    Directory of Open Access Journals (Sweden)

    P. Miletić

    2009-01-01

    Full Text Available The influence of microwaves pre-treatment of raw plant materials (wooded greenery and fruits of conifers-fir, spruce, pine, juniper and Douglas fir on the kinetics of the essential oil hydrodistillation using the Unger-type apparatus was studied. These plant materials are important feedstocks in the Republic of Srpska, as they could be used for the industrial production of essential oils for pharmaceutical, cosmetic and food industries. The main goal was to find out how the microwave pre-treatment of the raw plant materials affected the duration of hydrodistillation and the final yield of the essential oil. The application of microwaves pre-treatment shortened the hydrodistillation process which could significantly affect the economy of the essential oil production.

  4. On Integrating Mobile Applications into the Digital Forensic Investigative Process

    Directory of Open Access Journals (Sweden)

    April Tanner

    2013-09-01

    Full Text Available What if a tool existed that allowed digital forensic investigators to create their own apps that would assist them with the evidence identification and collection process at crime scenes? First responders are responsible for ensuring that digital evidence is examined in such a way that the integrity of the evidence is not jeopardized. Furthermore, they play a pivotal part in preserving evidence during the collection of evidence at the crime scene and transport to the laboratory. This paper proposes the development of a mobile application that can be developed for or created by a first responder to assist in the identification, acquisition, and preservation of digital evidence at a crime scene.

  5. Application of statistical process control to qualitative molecular diagnostic assays

    LENUS (Irish Health Repository)

    O'Brien, Cathal P.

    2014-11-01

    Modern pathology laboratories and in particular high throughput laboratories such as clinical chemistry have developed a reliable system for statistical process control (SPC). Such a system is absent from the majority of molecular laboratories and where present is confined to quantitative assays. As the inability to apply SPC to an assay is an obvious disadvantage this study aimed to solve this problem by using a frequency estimate coupled with a confidence interval calculation to detect deviations from an expected mutation frequency. The results of this study demonstrate the strengths and weaknesses of this approach and highlight minimum sample number requirements. Notably, assays with low mutation frequencies and detection of small deviations from an expected value require greater sample numbers to mitigate a protracted time to detection. Modeled laboratory data was also used to highlight how this approach might be applied in a routine molecular laboratory. This article is the first to describe the application of SPC to qualitative laboratory data.

  6. Modelling of Electrokinetic Processes in Civil and Environmental Engineering Applications

    DEFF Research Database (Denmark)

    Paz-Garcia, Juan Manuel; Johannesson, Björn; Ottosen, Lisbeth M.;

    2011-01-01

    increases the understanding of the main physicochemical aspects affecting the process. Results from simulations of some test examples are presented, showing the versatility of the model. Two types of enhanced methods are compared: The electrokinetic desalination of a brick sample, using carbonated clay......A mathematical model for the electrokinetic phenomena is described. Numerical simulations of different applications of electrokinetic techniques to the fields of civil and environmental engineering are included, showing the versatility and consistency of the model. The electrokinetics phenomena...... the porous materials undergoes an electroosmotic flow subject to externally applied electric fields. Electroosmotic transport makes electrokinetic techniques suitable for the mobilization of non-charged particles within the pore structure, such as the organic contaminants in soil. Chemical equilibrium...

  7. GRID Prototype for imagery processing in scientific applications

    International Nuclear Information System (INIS)

    The paper presents the results of our study which is part of the InGRID project. This project is supported by ROSA (ROmanian Space Agency). In this paper we will show the possibility to take images from the optical microscope through web camera. The images are then stored on the PC in Linux operating system and distributed to other clusters through GRID technology (using http, php, MySQL, Globus or AliEn systems). The images are provided from nuclear emulsions in the frame of Becquerel Collaboration. The main goal of the project InGRID is to actuate developing and deploying GRID technology for images technique taken from space, different application fields and telemedicine. Also it will create links with the same international projects which use advanced Grid technology and scalable storage solutions. The main topics proposed to be solved in the frame of InGRID project are: - Implementation of two GRID clusters, minimum level Tier 3; - Adapting and updating the common storage and processing computing facility; - Testing the middelware packages developed in the frame of this project; - Testbed production of the prototype; - Build-up and advertise the InGRID prototype in scientific community through current dissemination. InGRID Prototype developed in the frame of this project, will be used by partner institutes as deploying environment of the imaging applications the dynamical features of which will be defined by conditions of contract. Subsequent applications will be deployed by the partners of this project with governmental, nongovernmental and private institutions. (authors)

  8. System Choice for Data Processing, Analysis and Applications in Defence

    Directory of Open Access Journals (Sweden)

    Y. S. Rajan

    1995-10-01

    Full Text Available The design of a suitable system for image data processing, analysis and applications in Defence is governed by users' requirements during peace time and prehostility/hostility period. The users need timely information and image products for decision-making. The product specifications in terms of their scale, geometrical accuracy, information content, and turnaround time among other things are crucial for the design of systems. The systems are not complete without efficient software for information extraction and analysis and for aiding decision-making process. Usually, the base data is from high resolution remote sensing systems, both airborne and spaceborne, and also from conventional sources, like topomap and other intelligence gathering mechanisms. The database thus evolved is basic and vital for a decision support system. The sensors providing input to the database creation could be airborne high resolution camera systems, high resolution synthetic aperture radar systems and thermal imaging systems operating from a stand-off range of 50 to 100 km, or from high resolution spaceborne panchromatic optical and synthetic aperture radar imagery. High resolution stereo data from airborne and spaceborne sensors are also increasingly needed for image interpretation and analysis. The digital elevation data is another important information, derived from either existing topographic maps or high resolution space stereo imagery. The system also should cater to a large information archival/retrieval system and data dissimination system for the users spread far and wide. This may call for to and fro traffic between central operational system and units spread over different locations, preferably, through high speed satellite communication channels. Finally, the total system should have reliability, data security, adequate redundancy, user-friendliness and be efficient enough to provide timely information transfer for the decision makers. This paper discusses

  9. Application of hydrolyzed proteins of animal origin in processed meat.

    Science.gov (United States)

    Meinert, Lene; Broge, Eva Honnens de Lichtenberg; Bejerholm, Camilla; Jensen, Kirsten

    2016-03-01

    With increasing consumer interest in functional foods, proteins from slaughterhouse side streams can offer interesting application opportunities in this respect. Worldwide, increasing numbers of people are suffering from hypertension and protein deficiency. Hydrolyzed proteins of animal origin may show ACE-inhibitory activity, which is central to the treatment of hypertension. Furthermore, the protein content of, for example, meat products increases markedly through the addition of hydrolyzed proteins, and these protein-rich products are of interest to those suffering from protein deficiency. Through a series of analyses, six selected hydrolysates were analyzed for their application potential in the Danish meat product saveloy. Hydrolyzed pig rectum and bovine diaphragm showed the highest ACE-inhibitory activities, and these activities were maintained in the processed saveloys. The ACE-inhibitory activities could not readily be explained by the amino acid profile. The content of N-compounds in the saveloys increased with increasing addition of hydrolysate, with little difference between the added hydrolysates. A sensory panel assessed the saveloys with added porcine rectum (8%), bovine diaphragm (8%), and bovine heart (4% and 8%) as having the strongest off-flavors (chemical flavor). No increase in salty taste resulting from the addition of hydrolysates was detected in the saveloys. Finally, the consumers found the saveloys too mild in flavor and recommended the addition of more spices. PMID:27004118

  10. Image processing and applications based on visualizing navigation service

    Science.gov (United States)

    Hwang, Chyi-Wen

    2015-07-01

    When facing the "overabundant" of semantic web information, in this paper, the researcher proposes the hierarchical classification and visualizing RIA (Rich Internet Application) navigation system: Concept Map (CM) + Semantic Structure (SS) + the Knowledge on Demand (KOD) service. The aim of the Multimedia processing and empirical applications testing, was to investigating the utility and usability of this visualizing navigation strategy in web communication design, into whether it enables the user to retrieve and construct their personal knowledge or not. Furthermore, based on the segment markets theory in the Marketing model, to propose a User Interface (UI) classification strategy and formulate a set of hypermedia design principles for further UI strategy and e-learning resources in semantic web communication. These research findings: (1) Irrespective of whether the simple declarative knowledge or the complex declarative knowledge model is used, the "CM + SS + KOD navigation system" has a better cognition effect than the "Non CM + SS + KOD navigation system". However, for the" No web design experience user", the navigation system does not have an obvious cognition effect. (2) The essential of classification in semantic web communication design: Different groups of user have a diversity of preference needs and different cognitive styles in the CM + SS + KOD navigation system.

  11. Application of repetitive pulsed power technology to chemical processing

    International Nuclear Information System (INIS)

    The numerous sites of soil and water contaminated with organic chemicals present an urgent environmental concern that continues to grow. Electron and x-ray irradiation have been shown to be effective methods to destroy a wide spectrum of organic chemicals, nitrates, nitrites, and cyanide in water by breaking molecules to non-toxic products or entirely mineralizing the by-products to gas, water, and salts. Sandia National Laboratories is developing Repetitive High Energy Pulsed Power (RHEPP) technology capable of producing high average power, broad area electron or x-ray beams. The 300 kW RHEPP-II facility accelerates electrons to 2.5 MeV at 25 kA over 1,000 cm2 in 60 ns pulses at repetition rates of over 100 Hz. Linking this modular treatment capability with the rapid optical-sensing diagnostics and neutral network characterization software algorithms will provide a Smart Waste Treatment (SWaT) system. Such a system would also be applicable for chemical manufacture and processing of industrial waste for reuse or disposal. This talk describes both the HREPP treatment capability and sensing technologies. Measurements of the propagated RHEPP-II beam and dose profiles are presented. Sensors and rapid detection software are discussed with application toward chemical treatment

  12. Persistence of Multidrug-Resistant Acinetobacter baumannii Isolates Harboring blaOXA-23 and bap for 5 Years.

    Science.gov (United States)

    Sung, Ji Youn; Koo, Sun Hoe; Kim, Semi; Kwon, Gye Cheol

    2016-08-28

    The emergence and dissemination of carbapenemase-producing Acinetobacter baumannii isolates have been reported worldwide, and A. baumannii isolates harboring blaOXA-23 are often resistant to various antimicrobial agents. Antimicrobial resistance can be particularly strong for biofilm-forming A. baumannii isolates. We investigated the genetic basis for carbapenem resistance and biofilm-forming ability of multidrug-resistant (MDR) clinical isolates. Ninety-two MDR A. baumannii isolates were collected from one university hospital located in the Chungcheong area of Korea over a 5-year period. Multiplex PCR and DNA sequencing were performed to characterize carbapenemase and bap genes. Clonal characteristics were analyzed using REP-PCR. In addition, imaging and quantification of biofilms were performed using a crystal violet assay. All 92 MDR A. baumannii isolates involved in our study contained the blaOXA-23 and bap genes. The average absorbance of biomass in Bap-producing strains was much greater than that in non-Bap-producing strains. In our study, only three REP-PCR types were found, and the isolates showing type A or type B were found more than 60 times among unique patients during the 5 years of surveillance. These results suggest that the isolates have persisted and colonized for 5 years, and biofilm formation ability has been responsible for their persistence and colonization.

  13. BENEFICIAL FACE OF BACTERIOPHAGES: APPLICATIONS IN FOOD PROCESSING

    Directory of Open Access Journals (Sweden)

    H. V. Raghu

    2012-06-01

    Full Text Available Foods are processed to make them available at all places; consequently, our awareness regarding hygiene measures in food production has also increased dramatically over the last decades. In many countries cases associated with foodborne infectious are increased. However, available techniques are unable to effectively control the problem. Further, exploring novel methods and technologies for ensuring the safety of food with effective quality control approaches are under research. Phages are the natural enemies of bacteria, and are more specific to host renders them ideal candidates for applications designed to increase food safety during the production process. Scientific findings are available showing the possibility to use as biocontrol agents against various pathogens with out interfering with the natural microflora or the cultures in fermented products. Furthermore, phages or phage derived proteins can also be used to detect the presence of unwanted pathogens in food or the production environments, which allows quick and sp ecific identification of viable cells. Bacteriophages are natural, found in various environments including water; foods etc. and are not found significantly influence the human cells.

  14. Process, structure, property and applications of metallic glasses

    Directory of Open Access Journals (Sweden)

    B. Geetha Priyadarshini

    2016-07-01

    Full Text Available Metallic glasses (MGs are gaining immense technological significance due to their unique structure-property relationship with renewed interest in diverse field of applications including biomedical implants, commercial products, machinery parts, and micro-electro-mechanical systems (MEMS. Various processing routes have been adopted to fabricate MGs with short-range ordering which is believed to be the genesis of unique structure. Understanding the structure of these unique materials is a long-standing unsolved mystery. Unlike crystalline counterpart, the outstanding properties of metallic glasses owing to the absence of grain boundaries is reported to exhibit high hardness, excellent strength, high elastic strain, and anti-corrosion properties. The combination of these remarkable properties would significantly contribute to improvement of performance and reliability of these materials when incorporated as bio-implants. The nucleation and growth of metallic glasses is driven by thermodynamics and kinetics in non-equilibrium conditions. This comprehensive review article discusses the various attributes of metallic glasses with an aim to understand the fundamentals of relationship process-structure-property existing in such unique class of material.

  15. Fabrication of Diamond Nanowires for Quantum Information Processing Applications

    CERN Document Server

    Hausmann, Birgit; Babinec, Tom; Zhang, Yinan; Martinick, Katie; McCutcheon, Murray; Hemmer, Phil; Loncar, Marko

    2009-01-01

    We present a design and a top-down fabrication method for realizing diamond nanowires in both bulk single crystal and polycrystalline diamond for quantum information processing (QIP) applications. Inductively coupled plasma (ICP) reactive ion etching (RIE) with oxygen is used to fabricate the nanowires. Drop-casted nanoparticles (including Au, SiO2 and Al2O3) as well as electron beam lithography defined spin-on glass and evaporated Au have been used as an etch mask. We found Al2O3 nanoparticles to be the most etch resistant and Au nanoparticles and evaporated Au to have the same etch rate of 25nm/min. FOx e-beam resist (spin-on glass) had an etch rate of 10nm/min and proved to be the most suitable etch mask based on our fabrication process. We were able to obtain nanowires with near vertical sidewalls in both polycrystalline and single crystal diamond. The heights and diameters of the polycrystalline nanowires presented in this paper are 1um and 120-340nm, respectively, having a 200nm/min etch rate. In the ca...

  16. Bi-static sonar applications of intensity processing.

    Science.gov (United States)

    Naluai, Nathan K; Lauchle, Gerald C; Gabrielson, Thomas B; Joseph, John H

    2007-04-01

    Acoustic intensity processing of signals from directional sonobuoy acoustic subsystems is used to enhance the detection of submerged bodies in bi-static sonar applications. In some directions, the scattered signals may be completely dominated by the incident blast from the source, depending upon the geometry, making the object undetectable by traditional pressure measurements. Previous theoretical derivations suggest that acoustic vector intensity sensors, and the associated intensity processing, are a potential solution to this problem. Deep water experiments conducted at Lake Pend Oreille in northern Idaho are described. A large, hollow cylindrical body is located between a source and a number of SSQ-53D sonobuoys positioned from 5 to 30 body lengths away from the scattering body. Measurements show changes in the acoustic pressure of less than 0.5 dB when the scattering body is inserted in the field. However, the phase of the acoustic intensity component formed between the acoustic pressure and particle velocity component orthogonal to the direction of incident wave propagation varies by as much as 55 degrees. This metric is shown to be a repeatable and strong indicator of the presence of the scattering body. PMID:17471706

  17. Application of low intensity ultrasonics to cheese manufacturing processes.

    Science.gov (United States)

    Benedito, J; Carcel, J A; Gonzalez, R; Mulet, A

    2002-05-01

    Ultrasound has been used to non-destructively assess the quality of many foods such as meat, fish, vegetables and dairy products. This paper addresses the applications of low intensity ultrasonics in the cheese manufacturing processes and highlights the areas where ultrasonics could be successfully implemented in the future. The decrease of ultrasonic attenuation during the renneting process can be used to determine the optimum cut time for cheese making. The ultrasonic velocity increases during maturation for those types of cheese that become harder during this manufacturing stage, thus being an indicator of the maturity degree. Moreover, ultrasonic measurements could be linked to sensory parameters. From the ultrasonic velocity measurements at two different temperatures, it is possible to assess cheese composition, thus allowing an improvement in the quality and uniformity of cheese commercialization. In addition, in pulse-echo mode it is possible to detect cracked pieces due to abnormal fermentations and also to assess the distance of the crack from the surface. PMID:12159930

  18. The molecular phenomena of the blaZ genes forming betalactamase enzymes structure in Staphylococcus aureus resistant to beta-lactam antibiotics (ampicillin

    Directory of Open Access Journals (Sweden)

    Mieke Satari

    2010-09-01

    Full Text Available Background: Nowadays, infectious disease still an important problem. One of the bacteria causing infectious diseases is Staphylococcus aureus (S. aureus. In the effort to deal with infections caused by S. aureus, beta-lactam antibiotics, such as ampicillin, are used. In fact, it is unfortunately known that many of S. aureus bacteria are resistant to this group of antibiotics. Because of nucleotide base changes in the structure of the genes blaZ which encode beta-lactamase enzymes in S. aureus. Purpose: The objective of this study was to analyze the nucleotide base changes in the structure of the genes blaZ forming beta-lactamase enzymes in S. aureus resistant to ampicillin based on molecular point of view. Methods: Molecular examinations was conducted by isolating the genes, forming beta-lactamase enzyme, which length was 845bp, from 7 isolates of S. aureus resistant to ampicillin by using PCR technique. The results of blaZ amplification were then subjected to homology by using Tn 552 of S. aureus obtained from bank of genes. Results: Based on the result of the homology, it was found that there was a change in purine base TG, which was a pyrimidine base at the -37 position of the initial codon of blaZ. This change, however, did not affect the strength of the promoter since the number of A and T is still more than the number of G and C. In the structure of the blaZ gene there was even no mutation or deletion or nucleotide base substitution found, so it would not affect the effectiveness of beta-lactamase enzyme. Conclusion: It can be concluded that the resistance of S. aureus towards ampicillin was not caused by nucleotide base deletion/substation. It is suspected that there were other causes leading to the resistance, including the overproduction of beta-lactamase enzyme of the blaZ gene, causing the degradation of beta-lactam antibiotics.Latar belakang: Penyakit infeksi sampai saat ini masih merupakan masalah. Salah satu bakteri penyebab

  19. Application of Gaussian Process Modeling to Analysis of Functional Unreliability

    Energy Technology Data Exchange (ETDEWEB)

    R. Youngblood

    2014-06-01

    This paper applies Gaussian Process (GP) modeling to analysis of the functional unreliability of a “passive system.” GPs have been used widely in many ways [1]. The present application uses a GP for emulation of a system simulation code. Such an emulator can be applied in several distinct ways, discussed below. All applications illustrated in this paper have precedents in the literature; the present paper is an application of GP technology to a problem that was originally analyzed [2] using neural networks (NN), and later [3, 4] by a method called “Alternating Conditional Expectations” (ACE). This exercise enables a multifaceted comparison of both the processes and the results. Given knowledge of the range of possible values of key system variables, one could, in principle, quantify functional unreliability by sampling from their joint probability distribution, and performing a system simulation for each sample to determine whether the function succeeded for that particular setting of the variables. Using previously available system simulation codes, such an approach is generally impractical for a plant-scale problem. It has long been recognized, however, that a well-trained code emulator or surrogate could be used in a sampling process to quantify certain performance metrics, even for plant-scale problems. “Response surfaces” were used for this many years ago. But response surfaces are at their best for smoothly varying functions; in regions of parameter space where key system performance metrics may behave in complex ways, or even exhibit discontinuities, response surfaces are not the best available tool. This consideration was one of several that drove the work in [2]. In the present paper, (1) the original quantification of functional unreliability using NN [2], and later ACE [3], is reprised using GP; (2) additional information provided by the GP about uncertainty in the limit surface, generally unavailable in other representations, is discussed

  20. Nanoemulsion: process selection and application in cosmetics--a review.

    Science.gov (United States)

    Yukuyama, M N; Ghisleni, D D M; Pinto, T J A; Bou-Chacra, N A

    2016-02-01

    In recent decades, considerable and continuous growth in consumer demand in the cosmetics field has spurred the development of sophisticated formulations, aiming at high performance, attractive appearance, sensorial benefit and safety. Yet despite increasing demand from consumers, the formulator faces certain restrictions regarding the optimum equilibrium between the active compound concentration and the formulation base taking into account the nature of the skin structure, mainly concerning to the ideal penetration of the active compound, due to the natural skin barrier. Emulsion is a mixture of two immiscible phases, and the interest in nanoscale emulsion has been growing considerably in recent decades due to its specific attributes such as high stability, attractive appearance and drug delivery properties; therefore, performance is expected to improve using a lipid-based nanocarrier. Nanoemulsions are generated by different approaches: the so-called high-energy and low-energy methods. The global overview of these mechanisms and different alternatives for each method are presented in this paper, along with their benefits and drawbacks. As a cosmetics formulation is reflected in product delivery to consumers, nanoemulsion development with prospects for large-scale production is one of the key attributes in the method selection process. Thus, the aim of this review was to highlight the main high- and low-energy methods applicable in cosmetics and dermatological product development, their specificities, recent research on these methods in the cosmetics and consideration for the process selection optimization. The specific process with regard to inorganic nanoparticles, polymer nanoparticles and nanocapsule formulation is not considered in this paper. PMID:26171789

  1. Enzymes from Seafood Processing Waste and Their Applications in Seafood Processing.

    Science.gov (United States)

    Venugopal, V

    2016-01-01

    Commercial fishery processing results in discards up to 50% of the raw material, consisting of scales, shells, frames, backbones, viscera, head, liver, skin, belly flaps, dark muscle, roe, etc. Besides, fishing operations targeted at popular fish and shellfish species also result in landing of sizeable quantity of by-catch, which are not of commercial value because of their poor consumer appeal. Sensitivity to rapid putrefaction of fishery waste has serious adverse impact on the environment, which needs remedial measures. Secondary processing of the wastes has potential to generate a number of valuable by-products such as proteins, enzymes, carotenoids, fat, and minerals, besides addressing environmental hazards. Fishery wastes constitute good sources of enzymes such as proteases, lipases, chitinase, alkaline phosphatase, transglutaminase, hyaluronidase, acetyl glycosaminidase, among others. These enzymes can have diverse applications in the seafood industry, which encompass isolation and modification of proteins and marine oils, production of bioactive peptides, acceleration of traditional fermentation, peeling and deveining of shellfish, scaling of finfish, removal of membranes from fish roe, extraction of flavors, shelf life extension, texture modification, removal of off-odors, and for quality control either directly or as components of biosensors. Enzymes from fish and shellfish from cold habitats are particularly useful since they can function comparatively at lower temperatures thereby saving energy and protecting the food products. Potentials of these applications are briefly discussed. PMID:27452165

  2. Multidrug resistance and transferability of blaCTX-M among extended-spectrum β-lactamase-producing enteric bacteria in biofilm.

    Science.gov (United States)

    Maheshwari, Meenu; Ahmad, Iqbal; Althubiani, Abdullah Safar

    2016-09-01

    This study aimed to investigate the occurrence of biofilm-forming extended-spectrum β-lactamase (ESBL)-producing enteric bacteria in hospital wastewater and to evaluate their antibiotic resistance behaviour and transferability of the plasmid-encoded blaCTX-M gene in biofilm. ESBL production was confirmed using the combined disc test and Etest. Amplification of blaCTX-M was performed by PCR. Antibiotic susceptibility was evaluated using the disc diffusion assay and broth dilution method. Transfer of blaCTX-M in planktonic and biofilm state was performed by broth mating and filter mating experiments, respectively. Among 110 enteric bacteria, 24 (21.8%) isolates belonging to Escherichia coli, Klebsiella pneumoniae and Enterobacter cloacae were found to produce ESBL and formed varying levels of biofilm in vitro. Presence of blaCTX-M was detected in 18 (75%) ESBL-producing isolates. A many fold increase in resistance to antibiotics was observed in biofilm. Among ESBL-producers, seven isolates could transfer the blaCTX-M gene by conjugation, with transfer frequencies ranging from 2.22×10(-4) to 7.14×10(-2) transconjugants/recipient cell in the planktonic state and from 3.04×10(-3) to 9.15×10(-1) in biofilm. The transfer frequency of blaCTX-M was significantly higher in biofilm compared with the planktonic state, and co-transfer of ciprofloxacin resistance was also detected in five isolates. This study demonstrates that biofilm-forming ESBL-producing enteric bacteria with a greater transfer frequency of resistance genes will lead to frequent dissemination of β-lactam and fluoroquinolone resistance genes in environmental settings. The emergence and spread of such multidrug resistance is a serious threat to animal and public health. PMID:27530857

  3. Influence of agricultural practice on mobile bla genes: IncI1-bearing CTX-M, SHV, CMY and TEM in Escherichia coli from intensive farming soils.

    Science.gov (United States)

    Jones-Dias, Daniela; Manageiro, Vera; Caniça, Manuela

    2016-01-01

    Many calls have been made to address antibiotic resistance in an environmental perspective. With this study, we showed the widespread presence of high-level antibiotic resistant isolates on a collection of non-susceptible Gram-negative bacteria (n = 232) recovered from soils. Bacteria were selected using amoxicillin, cefotaxime and imipenem, from sites representing different agricultural practices (extensive, intensive and organic). Striking levels of non-susceptibility were noticed in intensive soils for norfloxacin (74%), streptomycin (50.7%) and tetracycline (46.6%); indeed, the exposure to intensive agricultural practices constituted a risk factor for non-susceptibility to many antibiotics, multidrug resistance and production of extended-spectrum β-lactamases (ESBL). Analyses of non-susceptibility highlighted that environmental and clinical bacteria from the same species might not share the same intrinsic resistance patterns, raising concerns for therapy choices in environment-borne infections. The multiple sequence-type IncI1-driven spread of penicillinases (blaTEM-1, blaTEM-135), ESBL (blaSHV-12 and blaCTX-M-1) and plasmid-mediated AmpC β-lactamases (blaCMY-2), produced by isolates that share their molecular features with isolates from humans and animals, suggests contamination of agricultural soils. This is also the first appearance of IncI1/ST28-harbouring blaCTX-M-1, which should be monitored to prevent their establishment as successfully dispersed plasmids. This research may help disclose paths of contamination by mobile antibiotic resistance determinants and the risks for their dissemination.

  4. Complete Nucleotide Sequences of Two blaKPC-2-Bearing IncN Plasmids Isolated from Sequence Type 442 Klebsiella pneumoniae Clinical Strains Four Years Apart

    Science.gov (United States)

    Pérez-Chaparro, Paula Juliana; Cerdeira, Louise Teixeira; Queiroz, Maíse Gomes; de Lima, Clayton Pereira Silva; Levy, Carlos Emílio; Pavez, Mónica; Lincopan, Nilton; Gonçalves, Evonnildo Costa; Mamizuka, Elsa Masae; Sampaio, Jorge Luiz Mello; Nunes, Marcio Roberto Teixeira

    2014-01-01

    We sequenced the oldest blaKPC-2-bearing plasmid isolated in Brazil and another plasmid also carried by a Klebsiella pneumoniae strain of sequence type 442 (ST442), isolated 52 months later. Both plasmids present an IncN backbone and few acquired regions. Because the 2005 plasmid presented deletions and a truncated gene within Tn4401b compared to the 2009 plasmid, we can thus infer that IncN blaKPC-2-bearing plasmids pFCF1305 and pFCF3SP had a common ancestor circulating in Brazil prior to May 2005. PMID:24566176

  5. Complete Nucleotide Sequences of Two blaKPC-2-Bearing IncN Plasmids Isolated from Sequence Type 442 Klebsiella pneumoniae Clinical Strains Four Years Apart

    OpenAIRE

    Paula Juliana PÉREZ-CHAPARRO; Cerdeira, Louise Teixeira; Queiroz, Maíse Gomes; de Lima, Clayton Pereira Silva; Levy, Carlos Emílio; Pavez, Mónica; Lincopan, Nilton; Gonçalves, Evonnildo Costa; Mamizuka, Elsa Masae; Sampaio, Jorge Luiz Mello; Nunes, Marcio Roberto Teixeira; McCulloch, John Anthony

    2014-01-01

    We sequenced the oldest blaKPC-2-bearing plasmid isolated in Brazil and another plasmid also carried by a Klebsiella pneumoniae strain of sequence type 442 (ST442), isolated 52 months later. Both plasmids present an IncN backbone and few acquired regions. Because the 2005 plasmid presented deletions and a truncated gene within Tn4401b compared to the 2009 plasmid, we can thus infer that IncN blaKPC-2-bearing plasmids pFCF1305 and pFCF3SP had a common ancestor circulating in Brazil prior to Ma...

  6. The IncI1 plasmid carrying the bla CTX-M-1 gene persists in in vitro culture of a Escherichia coli strain from broilers

    OpenAIRE

    Fischer, E.A.J.; Dierikx, C.M.; Essen-Zandbergen, van, A.; Roermund, van, C.W.T.; Mevius, D.J.; Stegeman, A; Klinkenberg, D.

    2014-01-01

    Background Commensal bacteria are a reservoir for antimicrobial-resistance genes. In the Netherlands, bacteria producing Extended Spectrum Beta-Lactamases (ESBL) are found on chicken-meat and in the gut of broilers at a high prevalence and the predominant ESBL-gene is the bla CTX-M-1 located on IncI1 plasmids. We aim to determine the fitness costs of this plasmid for the bacterium. We investigated the conjugation dynamics of IncI1 plasmids carrying the bla CTX-M-1 gene in a batch culture and ...

  7. A Plasmid Bearing the bla(CTX-M-15) Gene and Phage P1-Like Sequences from a Sequence Type 11 Klebsiella pneumoniae Isolate.

    Science.gov (United States)

    Shin, Juyoun; Ko, Kwan Soo

    2015-10-01

    Plasmid pKP12226 was extracted and analyzed from a CTX-M-15-producing Klebsiella pneumoniae sequence type 11 (ST11) isolate collected in South Korea. The plasmid represents chimeric characteristics consisting of a pIP1206-like backbone and lysogenized phage P1-like sequences. It bears a resistance region that includes resistance genes to several antibiotics and is different from previously characterized plasmids from South Korea bearing blaCTX-M-15. It may have resulted from recombination between an Escherichia coli plasmid backbone, a blaCTX-M-15-bearing resistance region, and lysogenized phage P1-like sequences. PMID:26195513

  8. High Prevalence of SXT/R391-Related Integrative and Conjugative Elements Carrying blaCMY-2 in Proteus mirabilis Isolates from Gulls in the South of France.

    Science.gov (United States)

    Aberkane, Salim; Compain, Fabrice; Decré, Dominique; Dupont, Chloé; Laurens, Chrislène; Vittecoq, Marion; Pantel, Alix; Solassol, Jérôme; Carrière, Christian; Renaud, François; Brieu, Nathalie; Lavigne, Jean-Philippe; Bouzinbi, Nicolas; Ouédraogo, Abdoul-Salam; Jean-Pierre, Hélène; Godreuil, Sylvain

    2016-02-01

    The genetic structures involved in the dissemination of blaCMY-2 carried by Proteus mirabilis isolates recovered from different gull species in the South of France were characterized and compared to clinical isolates. blaCMY-2 was identified in P. mirabilis isolates from 27/93 yellow-legged gulls and from 37/65 slender-billed gulls. It was carried by a conjugative SXT/R391-like integrative and conjugative element (ICE) in all avian strains and in 3/7 human strains. Two clinical isolates had the same genetic background as six avian isolates. PMID:26643344

  9. Membrane Lipid Analysis Applications to Monitoring Land Application of Food Processing Waste Water

    Science.gov (United States)

    Larson, R. A.; Fernandez-Torres, I.; Safferman, S. I.; Pfiffner, S. M.

    2008-12-01

    Land application of food processing waste is a common treatment technique relying on the soil assimilation capacity, including biological activity, for effective treatment. This treatment technique poses implications for ground water associated with metal leaching when excess loading occurs resulting in oxygen limitations. Determining prescriptive loadings that are protective of groundwater for food processors who dispose of wastewater by land application can be difficult due to site variability related to environmental conditions, application techniques, and varying wastewater characteristics. In an effort to responsibly practice wastewater land application, the use of soil sensors, soil leachate water quality parameters, and phospholipids measurements were researched to determine if assimilation could be predicted. Laboratory sand soil columns were constructed to mimic the conditions represented by food processing wastewater irrigation systems. Soil sensors for temperature, oxygen, and soil moisture were installed in the column and relayed semi-continuous data for the soil conditions within the soil columns. Results indicate the sensors predicted over loading that would result in metal leaching. Soil samples analyzed for phospholipid fatty acids further supported this data by categorizing the soil microbial community which indicates the treatment processes occurring within three depths (3, 12, and 20 inches) of the soil columns sampled before and after impact from excessive loading. Membrane lipid analyses uses GC/MS and HPLC/ES/MS/MS to provide estimates of biomass, phospholipid community profiles and respiratory quinone profiles. Biomasss estimates showed declining biomass with depth in the column. At the 3" depth the biomass averaged ~68,000 pmole/gdw, while biomass averaged ~500 and ~30 pmol/gdw for 12" and 20" depths, respectively. Specific phospholipids indicated the presence of fungi (18:2's) in the 3" depth and the presence of sulfate- reducing bacteria

  10. 微波技术应用%Application of Microwave Processing

    Institute of Scientific and Technical Information of China (English)

    王盼盼

    2009-01-01

    As a new development technique microwave technology has applied widely in areas of food processing. This article summarized the principles and characteristics of microwave technology and applications of microwave processing technology in meat products, cereals, fruits and vegetables processing. Some problems existed in microwave applications were analyzed. The development trend of microwave processing technology in food industry was put forward.

  11. Atmospheric Pressure Plasma-Electrospin Hybrid Process for Protective Applications

    Science.gov (United States)

    Vitchuli Gangadharan, Narendiran

    2011-12-01

    Chemical and biological (C-B) warfare agents like sarin, sulfur mustard, anthrax are usually dispersed into atmosphere in the form of micro aerosols. They are considered to be dangerous weapon of mass destruction next to nuclear weapons. The airtight protective clothing materials currently available are able to stop the diffusion of threat agents but not good enough to detoxify them, which endangers the wearers. Extensive research efforts are being made to prepare advanced protective clothing materials that not only prevent the diffusion of C-B agents, but also detoxify them into harmless products thus ensuring the safety and comfort of the wearer. Electrospun nanofiber mats are considered to have effective filtration characteristics to stop the diffusion of submicron level particulates without sacrificing air permeability characteristics and could be used in protective application as barrier material. In addition, functional nanofibers could be potentially developed to detoxify the C-B warfare threats into harmless products. In this research, electrospun nanofibers were deposited on fabric surface to improve barrier efficiency without sacrificing comfort-related properties of the fabrics. Multi-functional nanofibers were fabricated through an electrospinning-electrospraying hybrid process and their ability to detoxify simulants of C-B agents was evaluated. Nanofibers were also deposited onto plasma-pretreated woven fabric substrate through a newly developed plasma-electrospinning hybrid process, to improve the adhesive properties of nanofibers on the fabric surface. The nanofiber adhesion and durability properties were evaluated by peel test, flex and abrasion resistance tests. In this research work, following tasks have been carried out: i) Controlled deposition of nanofiber mat onto woven fabric substrate Electrospun Nylon 6 fiber mats were deposited onto woven 50/50 Nylon/Cotton fabric with the motive of making them into protective material against submicron

  12. Rapid Prototyping of High Performance Signal Processing Applications

    Science.gov (United States)

    Sane, Nimish

    Advances in embedded systems for digital signal processing (DSP) are enabling many scientific projects and commercial applications. At the same time, these applications are key to driving advances in many important kinds of computing platforms. In this region of high performance DSP, rapid prototyping is critical for faster time-to-market (e.g., in the wireless communications industry) or time-to-science (e.g., in radio astronomy). DSP system architectures have evolved from being based on application specific integrated circuits (ASICs) to incorporate reconfigurable off-the-shelf field programmable gate arrays (FPGAs), the latest multiprocessors such as graphics processing units (GPUs), or heterogeneous combinations of such devices. We, thus, have a vast design space to explore based on performance trade-offs, and expanded by the multitude of possibilities for target platforms. In order to allow systematic design space exploration, and develop scalable and portable prototypes, model based design tools are increasingly used in design and implementation of embedded systems. These tools allow scalable high-level representations, model based semantics for analysis and optimization, and portable implementations that can be verified at higher levels of abstractions and targeted toward multiple platforms for implementation. The designer can experiment using such tools at an early stage in the design cycle, and employ the latest hardware at later stages. In this thesis, we have focused on dataflow-based approaches for rapid DSP system prototyping. This thesis contributes to various aspects of dataflow-based design flows and tools as follows: 1. We have introduced the concept of topological patterns, which exploits commonly found repetitive patterns in DSP algorithms to allow scalable, concise, and parameterizable representations of large scale dataflow graphs in high-level languages. We have shown how an underlying design tool can systematically exploit a high

  13. 5th Seminar on Stochastic Processes, Random Fields and Applications

    CERN Document Server

    Russo, Francesco; Dozzi, Marco

    2008-01-01

    This volume contains twenty-eight refereed research or review papers presented at the 5th Seminar on Stochastic Processes, Random Fields and Applications, which took place at the Centro Stefano Franscini (Monte Verità) in Ascona, Switzerland, from May 30 to June 3, 2005. The seminar focused mainly on stochastic partial differential equations, random dynamical systems, infinite-dimensional analysis, approximation problems, and financial engineering. The book will be a valuable resource for researchers in stochastic analysis and professionals interested in stochastic methods in finance. Contributors: Y. Asai, J.-P. Aubin, C. Becker, M. Benaïm, H. Bessaih, S. Biagini, S. Bonaccorsi, N. Bouleau, N. Champagnat, G. Da Prato, R. Ferrière, F. Flandoli, P. Guasoni, V.B. Hallulli, D. Khoshnevisan, T. Komorowski, R. Léandre, P. Lescot, H. Lisei, J.A. López-Mimbela, V. Mandrekar, S. Méléard, A. Millet, H. Nagai, A.D. Neate, V. Orlovius, M. Pratelli, N. Privault, O. Raimond, M. Röckner, B. Rüdiger, W.J. Runggaldi...

  14. Application of Dynamic Speckle Techniques in Monitoring Biofilms Drying Process

    Science.gov (United States)

    Enes, Adilson M.; Júnior, Roberto A. Braga; Dal Fabbro, Inácio M.; da Silva, Washington A.; Pereira, Joelma

    2008-04-01

    Horticultural crops exhibit losses far greater than grains in Brazil which are associated to inappropriate maturation, mechanical bruising, infestation by microorganisms, wilting, etc. Appropriate packing prevents excessive mass loss associated to transpiration as well as to respiration, by controlling gas exchanging with outside environment. Common packing materials are identified as plastic films, waxes and biofilms. Although research developed with edible films and biopolymers has increased during last years to attend the food industry demands, avoiding environmental problems, little efforts have been reported on biofilm physical properties investigations. These properties, as drying time and biofilm interactions with environment are considered of basic importance. This research work aimed to contribute to development of a methodology to evaluate yucca (Maniot vulgaris) based biofilms drying time supported by a biospeckle technique. Biospeckle is a phenomenon generated by a laser beam scattered on a dynamic active surface, producing a time varying pattern which is proportional to the surface activity level. By capturing and processing the biospeckle image it is possible to attribute a numerical quantity to the surface bioactivity. Materials exhibiting high moisture content will also show high activity, which will support the drying time determination. Tests were set by placing biofilm samples on polyetilen plates and further submitted to laser exposition at four hours interval to capture the pattern images, generating the Intensities Dispersion Modulus. Results indicates that proposed methodology is applicable in determining biofilm drying time as well as vapor losses to environment.

  15. Natural Language Processing Technologies in Radiology Research and Clinical Applications.

    Science.gov (United States)

    Cai, Tianrun; Giannopoulos, Andreas A; Yu, Sheng; Kelil, Tatiana; Ripley, Beth; Kumamaru, Kanako K; Rybicki, Frank J; Mitsouras, Dimitrios

    2016-01-01

    The migration of imaging reports to electronic medical record systems holds great potential in terms of advancing radiology research and practice by leveraging the large volume of data continuously being updated, integrated, and shared. However, there are significant challenges as well, largely due to the heterogeneity of how these data are formatted. Indeed, although there is movement toward structured reporting in radiology (ie, hierarchically itemized reporting with use of standardized terminology), the majority of radiology reports remain unstructured and use free-form language. To effectively "mine" these large datasets for hypothesis testing, a robust strategy for extracting the necessary information is needed. Manual extraction of information is a time-consuming and often unmanageable task. "Intelligent" search engines that instead rely on natural language processing (NLP), a computer-based approach to analyzing free-form text or speech, can be used to automate this data mining task. The overall goal of NLP is to translate natural human language into a structured format (ie, a fixed collection of elements), each with a standardized set of choices for its value, that is easily manipulated by computer programs to (among other things) order into subcategories or query for the presence or absence of a finding. The authors review the fundamentals of NLP and describe various techniques that constitute NLP in radiology, along with some key applications. PMID:26761536

  16. Applications of Time-Reversal Processing for Planetary Surface Communications

    Science.gov (United States)

    Barton, Richard J.

    2007-01-01

    Due to the power constraints imposed on wireless sensor and communication networks deployed on a planetary surface during exploration, energy efficient transfer of data becomes a critical issue. In situations where groups of nodes within a network are located in relatively close proximity, cooperative communication techniques can be utilized to improve the range, data rate, power efficiency, and lifetime of the network. In particular, if the point-to-point communication channels on the network are well modeled as frequency non-selective, distributed or cooperative beamforming can employed. For frequency-selective channels, beamforming itself is not generally appropriate, but a natural generalization of it, time-reversal communication (TRC), can still be effective. Time-reversal processing has been proposed and studied previously for other applications, including acoustical imaging, electromagnetic imaging, underwater acoustic communication, and wireless communication channels. In this paper, we study both the theoretical advantages and the experimental performance of cooperative TRC for wireless communication on planetary surfaces. We give a brief introduction to TRC and present several scenarios where TRC could be profitably employed during planetary exploration. We also present simulation results illustrating the performance of cooperative TRC employed in a complex multipath environment and discuss the optimality of cooperative TRC for data aggregation in wireless sensor networks

  17. Application of a novel decontamination process using gaseous ozone

    Energy Technology Data Exchange (ETDEWEB)

    Moat, J.; Shone, J.; Upton, M. [Manchester Univ., School of Medecine, Manchester (United Kingdom). Medical Microbiology, Translation Medicine; Cargill, J. [Old Medical School, Leeds (United Kingdom). Dept. of Microbiology

    2009-08-15

    Hospital surfaces that are touched regularly by staff carry bacterial spores and pathogens. Environmental disinfection of health care facilities is an important aspect of infection control. This paper presented a recent innovation aimed at improving hospital hygiene and decontamination of laboratory equipment. The vapour- and gas-based treatment was developed to penetrate rooms or soft furnishings and reach places inaccessible by conventional approaches. Surfaces seeded with a range of vegetative cells and spores of bacteria of clinical relevance were decontaminated using the ozone-based treatment. The efficiency of the approach for room sanitization was also evaluated. A quenching agent was used to rapidly reduce ozone concentrations to safe levels allowing treatment times of less than 1 h for most of the organisms tested. Bacteria was seeded onto agar plates and solid surfaces. Reductions in bacterial load of greater than 3 log values were then recorded for a number of organisms including Escherichia coli and methicillin-resistant Staphylococcus aureus. Application of the process in a 30 m{sup 3} room showed similar reductions in viable counts for these organisms and for Clostridium difficile spores. It was concluded that ozone-based decontamination of healthcare environments could prove to be a highly cost-effective intervention. 35 refs., 1 tab., 3 figs.

  18. Onboard Radar Processing Development for Rapid Response Applications

    Science.gov (United States)

    Lou, Yunling; Chien, Steve; Clark, Duane; Doubleday, Josh; Muellerschoen, Ron; Wang, Charles C.

    2011-01-01

    We are developing onboard processor (OBP) technology to streamline data acquisition on-demand and explore the potential of the L-band SAR instrument onboard the proposed DESDynI mission and UAVSAR for rapid response applications. The technology would enable the observation and use of surface change data over rapidly evolving natural hazards, both as an aid to scientific understanding and to provide timely data to agencies responsible for the management and mitigation of natural disasters. We are adapting complex science algorithms for surface water extent to detect flooding, snow/water/ice classification to assist in transportation/ shipping forecasts, and repeat-pass change detection to detect disturbances. We are near completion of the development of a custom FPGA board to meet the specific memory and processing needs of L-band SAR processor algorithms and high speed interfaces to reformat and route raw radar data to/from the FPGA processor board. We have also developed a high fidelity Matlab model of the SAR processor that is modularized and parameterized for ease to prototype various SAR processor algorithms targeted for the FPGA. We will be testing the OBP and rapid response algorithms with UAVSAR data to determine the fidelity of the products.

  19. 40 CFR 459.10 - Applicability; description of the photographic processing subcategory.

    Science.gov (United States)

    2010-07-01

    ... photographic processing subcategory. 459.10 Section 459.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS PHOTOGRAPHIC POINT SOURCE CATEGORY Photographic Processing Subcategory § 459.10 Applicability; description of the photographic processing subcategory....

  20. First characterisation of plasmid-mediated quinolone resistance-qnrS1 co-expressed bla CTX-M-15 and bla DHA-1 genes in clinical strain of Morganella morganii recovered from a Tunisian Intensive Care Unit

    Directory of Open Access Journals (Sweden)

    S Mahrouki

    2012-01-01

    Full Text Available Purpose: Aim of this study was to show the emergence of the qnr genes among fluoroquinolone-resistant, AMPC and ESBL (extended-spectrum-beta-lactamase co-producing Morganella morganii isolate. Materials and Methods: A multi resistant Morganella morganii SM12012 isolate was recovered from pus from a patient hospitalized in the intensive care unit at the Military hospital, Tunisia. Antibiotic susceptibility was tested with the agar disk diffusion method according to Clinical and Laboratory Standards Institute guidelines. ESBLs were detected using a standard double-disk synergy test. The characterization of beta-lactamases and associated resistance genes were performed by isoelectric focusing, polymerase chain reaction and nucleotide sequencing. Results: The antimicrobial susceptibility testing showed the high resistance to penicillins, cephalosporins (MICs: 64-512 μg/ml and fluoroquinolones (MICs: 32-512 μg/ml. But M. morganii SM12012 isolate remained susceptible to carbapenems (MICs: 4-<0.25 μg/ml. The double-disk synergy test confirmed the phenotype of extended-spectrum β-lactamases (ESBLs. Three identical β-lactamases with pI values of 6.5, 7.8 and superior to 8.6 were detected after isoelectric focusing analysis. These β-lactamases genes can be successfully transferred by the conjugative plasmid. Molecular analysis demonstrated the co-production of bla DHA-1, bla CTX-M-15 and qnrS1 genes on the same plasmid. The detection of an associated chromosomal quinolone resistance revealed the presence of a parC mutation at codon 80 (Ser80-lle80. Conclusion: This is the first report in Tunisia of nosocomial infection due to the production of CTX-M-15 and DHA-1 β-lactamases in M. morganii isolate with the association of quinolone plasmid resistance. The incidence of these strains invites continuous monitoring of such multidrug-resistant strains and the further study of their epidemiologic evolution.

  1. A Holistic Approach for Modeling and Synthesis of Image Processing Applications for Heterogeneous Computing Architectures

    OpenAIRE

    Hartmann, Christian; Yupatova, Anna; Reichenbach, Marc; Fey, Dietmar; German, Reinhard

    2015-01-01

    Image processing applications are common in every field of our daily life. However, most of them are very complex and contain several tasks with different complexities which result in varying requirements for computing architectures. Nevertheless, a general processing scheme in every image processing application has a similar structure, called image processing pipeline: (1) capturing an image, (2) pre-processing using local operators, (3) processing with global operators and (4) post-processi...

  2. The Process Specification Language (PSL) Theory and Applications

    OpenAIRE

    Gruninger, Michael; Menzel, Christopher

    2003-01-01

    The PROCESS SPECIFICATION language (PSL) has been designed to facilitate correct and complete exchange of process information among manufacturing systems, such as scheduling, process modeling, process planning, production planning, simulation, project management, work flow, and business-process reengineering. We give an overview of the theories within the PSL ontology, discuss some of the design principles for the ontology, and finish with examples of process specifications that are based on ...

  3. Ethnic and gender differences in applicants' decision-making processes: An application of the theory of reasoned action

    OpenAIRE

    van Hooft, Edwin; Born, Marise; Taris, Toon; Flier, Henk

    2006-01-01

    textabstractAlthough a growing proportion of the new entrants into the workforce consist of women and ethnic minorities, relatively little is known about the recruitment and job choice processes of these applicant groups. Therefore, this study investigated cultural and gender differences in job application decision processes among 191 job seekers looking for temporary employment. The theory of reasoned action (TRA) was found to be a valid framework to explain job application decisions, althou...

  4. Opinions of Family Practitioners about Data Processing Applications

    Directory of Open Access Journals (Sweden)

    Kılınç AS

    2013-09-01

    Full Text Available Objective: In this study, it is aimed to evaluate the ideas of family practitioners who serving in Burdur in 2010 related to data processing applications. Methods: The data of this descriptive study was obtained with the questionnaire prepared by researchers which are filled out by family physicians. Results: At the time of the study, 73 family physicians were working in Burdur. 77.8% of family physicians were male. Family physicians’ mean age is 41± 6.1 yr. 57.8% of the physicians have worked in primary health care services for 10 years and more while 59.2% stated that they have worked less than 5 years in secondary health care services. All of family physicians were using the software which is called AHBS (Family Medicine Information System. 45.8% of family physicians were partially satisfied with AHBS while 30.6% were satisfied. 72.2% of them have reported error by data entries which are caused mostly by user and system errors and internet problems. System integration with other systems has been reported 37.5% as moderate and 20.8% as poor, 19.4% as very poor. As problems of integration; MERNIS (Central Population Management System cannot be reached (n=28 and the connection problems with exchange of data (n = 21 are established. For the education with computer or distance education, 42.6% are considered as good. 78.6% of family physicians think that correspondence must be done electronically. Conclusion: All of family physicians use AHBS. Family physicians that use information system are satisfied but there are problems with integration.

  5. Laser materials processing applications at Lawrence Livermore National Laboratory

    International Nuclear Information System (INIS)

    High power and high radiance laser technologies developed at Lawrence Livermore National Laboratory (LLNL) such as copper-vapor lasers, solid-state slab lasers, dye lasers, harmonic wavelength conversion of these lasers, and fiber optic delivery systems show great promise for material processing tasks. Evaluation of models suggests significant potential for tenfold increases in welding, cutting, and drilling performance, as well as capability for applications in emerging technologies such as micromachining, surface treatment, and stereolithography. Copper and dye laser systems are currently being developed at LLNL for uranium enrichment production facilities. The goals of this program are to develop low-cost, reliable and maintainable industrial laser systems. Chains of copper lasers currently operate at more than 1.5 kW output and achieve mean time between failures of more than 1,000 hours. The beam quality of copper vapor lasers is approximately three times the diffraction limit. Dye lasers have near diffraction limited beam quality at greater than 1.0 kW. Diode laser pumped, Nd:YAG slab lasers are also being developed at LLNL. Current designs achieve powers of greater than 1.0 kW and projected beam quality is in the two to five times diffraction limited range. Results from cutting and drilling studies in titanium and stainless steel alloys show that cuts and holes with extremely fine features can be made with dye and copper-vapor lasers. High radiance beams produce low distortion and small heat-affected zones. The authors have accomplished very high aspect ratio holes in drilling tests (> 60: 1) and features with micron scale (5-50 μm) sizes. Other, traditionally more difficult, materials such as copper, aluminum and ceramics will soon be studied in detail

  6. Draft genome sequence of a multidrug-resistant blaOXA-23-producing Acinetobacter baumannii ST208 isolate from China.

    Science.gov (United States)

    Chen, Yan; Wu, Liyan; Chen, Yu; Xu, Zhijun; Xu, Liqun

    2016-03-01

    Acinetobacter baumannii has emerged worldwide as an important opportunistic nosocomial pathogen and has become a major public health concern. In this study, the draft genome sequence of A. baumannii TCM331 (ST208/CC92), a multidrug-resistant (MDR) isolate harbouring the blaOXA-23 gene isolated in China, was determined. The genome of TCM331 was sequenced via Illumina HiSeq™ 2000, and bioinformatics analysis was performed. Important antimicrobial resistance determinants were observed in an estimated genome size of 4,058,691bp with 3838 predicted coding regions. In conclusion, these data might facilitate further understanding of the specific genomic features of MDR A. baumannii in China. PMID:27436391

  7. Clinical Specimen-Direct LAMP: A Useful Tool for the Surveillance of blaOXA-23-Positive Carbapenem-Resistant Acinetobacter baumannii.

    Science.gov (United States)

    Yamamoto, Norihisa; Hamaguchi, Shigeto; Akeda, Yukihiro; Santanirand, Pitak; Kerdsin, Anusak; Seki, Masafumi; Ishii, Yoshikazu; Paveenkittiporn, Wantana; Bonomo, Robert A; Oishi, Kazunori; Malathum, Kumthorn; Tomono, Kazunori

    2015-01-01

    Healthcare-associated infections are a leading cause of morbidity and mortality worldwide. Treatment is increasingly complicated by the escalating incidence of antimicrobial resistance. Among drug-resistant pathogens, carbapenem-resistant Acinetobacter baumannii (CRAb) is of increasing concern because of the limited applicable therapies and its expanding global distribution in developed countries and newly industrialized countries. Therefore, a rapid detection method that can be used even in resource-poor countries is urgently required to control this global public health threat. Conventional techniques, such as bacterial culture and polymerase chain reaction (PCR), are insufficient to combat this threat because they are time-consuming and laborious. In this study, we developed a loop-mediated isothermal amplification (LAMP) method for detecting blaOXA-23-positive CRAb, the most prevalent form of CRAb in Asia, especially in Thailand, and confirmed its efficacy as a surveillance tool in a clinical setting. Clinical samples of sputum and rectal swabs were collected from patients in a hospital in Bangkok and used for LAMP assays. After boiling and centrifugation, the supernatants were used directly in the assay. In parallel, a culture method was used for comparison purposes to evaluate the specificity and sensitivity of LAMP. As a first step, a total of 120 sputum samples were collected. The sensitivity of LAMP was 88.6% (39/44), and its specificity was 92.1% (70/76) using the culture method as the "gold standard". When surveillance samples including sputum and rectal swabs were analyzed with the LAMP assay, its sensitivity was 100.0%. This method enables the direct analysis of clinical specimens and provides results within 40 minutes of sample collection, making it a useful tool for surveillance even in resource-poor countries.

  8. Clinical Specimen-Direct LAMP: A Useful Tool for the Surveillance of blaOXA-23-Positive Carbapenem-Resistant Acinetobacter baumannii.

    Directory of Open Access Journals (Sweden)

    Norihisa Yamamoto

    Full Text Available Healthcare-associated infections are a leading cause of morbidity and mortality worldwide. Treatment is increasingly complicated by the escalating incidence of antimicrobial resistance. Among drug-resistant pathogens, carbapenem-resistant Acinetobacter baumannii (CRAb is of increasing concern because of the limited applicable therapies and its expanding global distribution in developed countries and newly industrialized countries. Therefore, a rapid detection method that can be used even in resource-poor countries is urgently required to control this global public health threat. Conventional techniques, such as bacterial culture and polymerase chain reaction (PCR, are insufficient to combat this threat because they are time-consuming and laborious. In this study, we developed a loop-mediated isothermal amplification (LAMP method for detecting blaOXA-23-positive CRAb, the most prevalent form of CRAb in Asia, especially in Thailand, and confirmed its efficacy as a surveillance tool in a clinical setting. Clinical samples of sputum and rectal swabs were collected from patients in a hospital in Bangkok and used for LAMP assays. After boiling and centrifugation, the supernatants were used directly in the assay. In parallel, a culture method was used for comparison purposes to evaluate the specificity and sensitivity of LAMP. As a first step, a total of 120 sputum samples were collected. The sensitivity of LAMP was 88.6% (39/44, and its specificity was 92.1% (70/76 using the culture method as the "gold standard". When surveillance samples including sputum and rectal swabs were analyzed with the LAMP assay, its sensitivity was 100.0%. This method enables the direct analysis of clinical specimens and provides results within 40 minutes of sample collection, making it a useful tool for surveillance even in resource-poor countries.

  9. Prior processes and their applications nonparametric Bayesian estimation

    CERN Document Server

    Phadia, Eswar G

    2016-01-01

    This book presents a systematic and comprehensive treatment of various prior processes that have been developed over the past four decades for dealing with Bayesian approach to solving selected nonparametric inference problems. This revised edition has been substantially expanded to reflect the current interest in this area. After an overview of different prior processes, it examines the now pre-eminent Dirichlet process and its variants including hierarchical processes, then addresses new processes such as dependent Dirichlet, local Dirichlet, time-varying and spatial processes, all of which exploit the countable mixture representation of the Dirichlet process. It subsequently discusses various neutral to right type processes, including gamma and extended gamma, beta and beta-Stacy processes, and then describes the Chinese Restaurant, Indian Buffet and infinite gamma-Poisson processes, which prove to be very useful in areas such as machine learning, information retrieval and featural modeling. Tailfree and P...

  10. Planning@SAP: An Application in Business Process Management

    OpenAIRE

    Hoffmann, Joerg; Weber, Ingo; Kraft, Frank

    2009-01-01

    International audience Business processes control the flow of activities within and between enterprises. Business Process Management is concerned, amongst other things, with the maintenance of these processes. In particular, it becomes ever more important to be able to quickly create modified processes for changed market conditions. We show that AI Planning can help with this, by automatically composing process skeletons. We formalize this as a particular form of planning with non-determin...

  11. Novel Applications of Space-Time Processing for Wireless Systems

    OpenAIRE

    Hult, Tommy

    2006-01-01

    Space-time processing techniques have emerged as one of the most promising areas of research and development in wireless communications. Space-time processing signifies the signal processing performed on a system consisting of several antenna elements, whose signals are processed adaptively in order to exploit both the spatial (space) and temporal (time) dimensions of the radio channel. Space-time processing techniques can be applied at the transmitter, the receiver or both. The use of space-...

  12. The IncI1 plasmid carrying the bla CTX-M-1 gene persists in in vitro culture of a Escherichia coli strain from broilers

    NARCIS (Netherlands)

    Fischer, E.A.J.; Dierikx, C.M.; Essen-Zandbergen, van A.; Roermund, van H.J.W.; Mevius, D.J.; Stegeman, A.; Klinkenberg, D.

    2014-01-01

    Commensal bacteria are a reservoir for antimicrobial-resistance genes. In the Netherlands, bacteria producing Extended Spectrum Beta-Lactamases (ESBL) are found on chicken-meat and in the gut of broilers at a high prevalence and the predominant ESBL-gene is the blaCTX-M-1 located on IncI1 plasmids.

  13. Complete nucleotide sequence of pGA45, a 140,698-bp incFIIY plasmid encoding blaIMI-3-mediated carbapenem resistance, from river sediment

    Directory of Open Access Journals (Sweden)

    Bingjun eDang

    2016-02-01

    Full Text Available Plasmid pGA45 was isolated from the sediment of Haihe River using E. coli CV601 (gfp-tagged as recipients and indigenous bacteria from sediment as donors. This plasmid confers reduced susceptibility to imipenem which belongs to carbapenem group. Plasmid pGA45 was fully sequenced on an Illumina HiSeq 2000 sequencing system. The complete sequence of plasmid pGA45 was 140,698 bp in length with an average G+C content of 52.03%. Sequence analysis shows that pGA45 belongs to incFIIY group and harbors a backbone region shares high homology and gene synteny to several other incF plasmids including pNDM1_EC14653, pYDC644, pNDM-Ec1GN574, pRJF866, pKOX_NDM1 and pP10164-NDM. In addition to the backbone region, plasmid pGA45 harbors two notable features including one blaIMI-3-containing region and one type VI secretion system region. The blaIMI-3-containing region is responsible for bacteria carbapenem resistance and the type VI secretion system region is probably involved in bacteria virulence, respectively. Plasmid pGA45 represents the first complete nucleotide sequence of the blaIMI-harboring plasmid from environment sample and the sequencing of this plasmid provided insight into the architecture used for the dissemination of blaIMI carbapenemase genes.

  14. Complete Nucleotide Sequence of pGA45, a 140,698-bp IncFIIY Plasmid Encoding bla IMI-3-Mediated Carbapenem Resistance, from River Sediment.

    Science.gov (United States)

    Dang, Bingjun; Mao, Daqing; Luo, Yi

    2016-01-01

    Plasmid pGA45 was isolated from the sediments of Haihe River using Escherichia coli CV601 (gfp-tagged) as recipients and indigenous bacteria from sediment as donors. This plasmid confers reduced susceptibility to imipenem which belongs to carbapenem group. Plasmid pGA45 was fully sequenced on an Illumina HiSeq 2000 sequencing system. The complete sequence of plasmid pGA45 was 140,698 bp in length with an average G + C content of 52.03%. Sequence analysis shows that pGA45 belongs to IncFIIY group and harbors a backbone region which shares high homology and gene synteny to several other IncF plasmids including pNDM1_EC14653, pYDC644, pNDM-Ec1GN574, pRJF866, pKOX_NDM1, and pP10164-NDM. In addition to the backbone region, plasmid pGA45 harbors two notable features including one bla IMI-3-containing region and one type VI secretion system region. The bla IMI-3-containing region is responsible for bacteria carbapenem resistance and the type VI secretion system region is probably involved in bacteria virulence, respectively. Plasmid pGA45 represents the first complete nucleotide sequence of the bla IMI-harboring plasmid from environment sample and the sequencing of this plasmid provided insight into the architecture used for the dissemination of bla IMI carbapenemase genes. PMID:26941718

  15. NDM-1-producing Enterobacteriaceae in a teaching hospital in Shanghai, China: IncX3-type plasmids may contribute to the dissemination of blaNDM-1

    Directory of Open Access Journals (Sweden)

    Hongping Qu

    2015-05-01

    Conclusion: This is the first report of NDM-1-positive Enterobacteriaceae from Shanghai, China. IncX3 plasmids, reported in various species in the United Arab Emirates and China, may contribute to the dissemination of blaNDM-1.. More attention should be devoted to monitoring the dissemination of the NDM-1 gene due to its potential horizontal transfer via mobile genetic elements.

  16. Molecular dissection of blaKPC-2-bearing plasmids evolving in Klebsiella pneumoniae isolated at one teaching hospital in Shanghai, China.

    Science.gov (United States)

    Shen, Pinghua; Zhang, Ying; Tang, Yu; Liang, Wei; Jiang, Xiaofei

    2016-08-01

    The presence of carbapenemase gene blaKPC-2 in a wide variety of plasmids, especially conjugative plasmids, is key to the rapid, worldwide spread of carbapenemase enzymes. Thirty-eight, non-duplicated, carbapenem-resistant, clinical Klebsiella pneumoniae isolates were collected, all carrying blaKPC-2-bearing plasmids. Relaxase analysis was used to classify these plasmids; 8 and 30 plasmids belonged to the MOBP3 and MOBF12 subfamilies, respectively. Phylogenetic analysis revealed two genetic subclades in the MOBF12 subfamily and suggested that these subclades might not have originated from the same ancestor. Crossing PCR, used to sequence fully the type IV secretion system (T4SS, essential structures for conjugative plasmids) of the MOBF12 plasmids, found that T4SSs were distinctively different in certain functional genes, e.g. traS and traG. In conclusion, this study delineated the evolution of blaKPC-2-bearing plasmids at Huashan Hospital, Shanghai, China. The plasmids bearing blaKPC-2 were diverse and the MOBF12 plasmids were dominant in clinical K. pneumoniae isolates. PMID:27252157

  17. Complete Sequence of Four Multidrug-Resistant MOBQ1 Plasmids Harboring blaGES-5 Isolated from Escherichia coli and Serratia marcescens Persisting in a Hospital in Canada.

    Science.gov (United States)

    Boyd, David; Taylor, Geoffrey; Fuller, Jeff; Bryce, Elizabeth; Embree, Joanne; Gravel, Denise; Katz, Kevin; Kibsey, Pamela; Kuhn, Magdalena; Langley, Joanne; Mataseje, Laura; Mitchell, Robyn; Roscoe, Diane; Simor, Andrew; Thomas, Eva; Turgeon, Nathalie; Mulvey, Michael

    2015-06-01

    The usefulness of carbapenems for gram-negative infections is becoming compromised by organisms harboring carbapenemases, enzymes which can hydrolyze the drug. Currently KPC (class A), NDM (class B), and OXA-48 types (class D) are the most globally widespread carbapenemases. However, among the GES-type class A extended-spectrum β-lactamases (ESBLs) there are variants that hydrolyze carbapenems, with blaGES-5 being the most common. Two Escherichia coli and two Serratia marcescens harboring blaGES-5 on plasmids were isolated by the Canadian Nosocomial Infection Surveillance Program (CNISP) from four different patients in a single hospital over a 2-year period. Complete sequencing of the blaGES-5 plasmids indicated that all four had nearly identical backbones consisting of genes for replication, partitioning, and stability, but contained variant accessory regions consisting of mobile elements and antimicrobial resistance genes. The plasmids were of a novel replicon type, but belonged to the MOBQ1 group based on relaxase sequences, and appeared to be mobilizable, but not self-transmissible. Considering the time periods of bacterial isolation, it would appear the blaGES-5 plasmid has persisted in an environmental niche for at least 2 years in the hospital. This has implications for infection control and clinical care when it is transferred to clinically relevant gram-negative organisms.

  18. A Carbapenem-Resistant Pseudomonas aeruginosa Isolate Harboring Two Copies of blaIMP-34 Encoding a Metallo-β-Lactamase.

    Directory of Open Access Journals (Sweden)

    Tatsuya Tada

    Full Text Available A carbapenem-resistant strain of Pseudomonas aeruginosa, NCGM1984, was isolated in 2012 from a hospitalized patient in Japan. Immunochromatographic assay showed that the isolate was positive for IMP-type metallo-β-lactamase. Complete genome sequencing revealed that NCGM1984 harbored two copies of blaIMP-34, located at different sites on the chromosome. Each blaIMP-34 was present in the same structures of the class 1 integrons, tnpA(ISPa7-intI1-qacG-blaIMP-34-aac(6'-Ib-qacEdelta1-sul1-orf5-tniBdelta-tniA. The isolate belonged to multilocus sequence typing ST235, one of the international high-risk clones. IMP-34, with an amino acid substitution (Glu126Gly compared with IMP-1, hydrolyzed all β-lactamases tested except aztreonam, and its catalytic activities were similar to IMP-1. This is the first report of a clinical isolate of an IMP-34-producing P. aeruginosa harboring two copies of blaIMP-34 on its chromosome.

  19. Complete Nucleotide Sequence of pGA45, a 140,698-bp IncFIIY Plasmid Encoding bla IMI-3-Mediated Carbapenem Resistance, from River Sediment.

    Science.gov (United States)

    Dang, Bingjun; Mao, Daqing; Luo, Yi

    2016-01-01

    Plasmid pGA45 was isolated from the sediments of Haihe River using Escherichia coli CV601 (gfp-tagged) as recipients and indigenous bacteria from sediment as donors. This plasmid confers reduced susceptibility to imipenem which belongs to carbapenem group. Plasmid pGA45 was fully sequenced on an Illumina HiSeq 2000 sequencing system. The complete sequence of plasmid pGA45 was 140,698 bp in length with an average G + C content of 52.03%. Sequence analysis shows that pGA45 belongs to IncFIIY group and harbors a backbone region which shares high homology and gene synteny to several other IncF plasmids including pNDM1_EC14653, pYDC644, pNDM-Ec1GN574, pRJF866, pKOX_NDM1, and pP10164-NDM. In addition to the backbone region, plasmid pGA45 harbors two notable features including one bla IMI-3-containing region and one type VI secretion system region. The bla IMI-3-containing region is responsible for bacteria carbapenem resistance and the type VI secretion system region is probably involved in bacteria virulence, respectively. Plasmid pGA45 represents the first complete nucleotide sequence of the bla IMI-harboring plasmid from environment sample and the sequencing of this plasmid provided insight into the architecture used for the dissemination of bla IMI carbapenemase genes.

  20. Empirical modeling, state estimation, and process control with real-life applications to the Czochralski crystallization process

    OpenAIRE

    Komperød, Magnus

    2012-01-01

    This PhD thesis presents research work within the field of systems and control engineering, with emphasis on applications to real-life processes, the Czochralski (CZ) crystallization process in particular. During the PhD study, two journal articles and five conference papers have been published. All seven publications are based on logged data from real-life processes or include examples based on such data. For four of the publications, logged process data are essential. The sev...

  1. 40 CFR 408.10 - Applicability; description of the farm-raised catfish processing subcategory.

    Science.gov (United States)

    2010-07-01

    ...-raised catfish processing subcategory. 408.10 Section 408.10 Protection of Environment ENVIRONMENTAL... SOURCE CATEGORY Farm-Raised Catfish Processing Subcategory § 408.10 Applicability; description of the farm-raised catfish processing subcategory. The provisions of this subpart are applicable to...

  2. 40 CFR 409.80 - Applicability; description of the Puerto Rican raw cane sugar processing subcategory.

    Science.gov (United States)

    2010-07-01

    ... Puerto Rican raw cane sugar processing subcategory. 409.80 Section 409.80 Protection of Environment... CATEGORY Puerto Rican Raw Cane Sugar Processing Subcategory § 409.80 Applicability; description of the Puerto Rican raw cane sugar processing subcategory. The provisions of this subpart are applicable...

  3. 40 CFR 409.40 - Applicability; description of the Louisiana raw cane sugar processing subcategory.

    Science.gov (United States)

    2010-07-01

    ... Louisiana raw cane sugar processing subcategory. 409.40 Section 409.40 Protection of Environment... CATEGORY Louisiana Raw Cane Sugar Processing Subcategory § 409.40 Applicability; description of the Louisiana raw cane sugar processing subcategory. The provisions of this subpart are applicable to...

  4. 40 CFR 409.70 - Applicability; description of the Hawaiian raw cane sugar processing subcategory.

    Science.gov (United States)

    2010-07-01

    ... Hawaiian raw cane sugar processing subcategory. 409.70 Section 409.70 Protection of Environment... CATEGORY Hawaiian Raw Cane Sugar Processing Subcategory § 409.70 Applicability; description of the Hawaiian raw cane sugar processing subcategory. The provisions of this subpart are applicable to...

  5. 40 CFR 458.10 - Applicability; description of the carbon black furnace process subcategory.

    Science.gov (United States)

    2010-07-01

    ... carbon black furnace process subcategory. 458.10 Section 458.10 Protection of Environment ENVIRONMENTAL... CATEGORY Carbon Black Furnace Process Subcategory § 458.10 Applicability; description of the carbon black furnace process subcategory. The provisions of this subpart are applicable to discharges resulting...

  6. Application Cases and Integration of Additive Manufacturing Processes into Conventional Process Chains by the Example of Tool Repair Using the Con-trolled Metal Build-Up Process

    OpenAIRE

    Wimmer, Felix

    2015-01-01

    In the first part of this thesis an overview of the most common Additive Manufacturing (AM) processes and a valid classification scheme outside of the classification of conventional ma-chining processes is presented. Advantages and shortcomings of these processes are briefly explained and application cases from the industry are given. Transitioning from the shortcom-ings of current Additive Manufacturing processes the so called “hybrid additive subtractive” processes are introduced.The concep...

  7. Application of finite-element-methods in food processing

    DEFF Research Database (Denmark)

    Risum, Jørgen

    2004-01-01

    Presentation of the possible use of finite-element-methods in food processing. Examples from diffusion studies are given.......Presentation of the possible use of finite-element-methods in food processing. Examples from diffusion studies are given....

  8. Chemistry and technology of nanoparticles : preparation, processing and application

    OpenAIRE

    Schmidt, Helmut K.

    1997-01-01

    A fabrication and a processing process of nanoparticles by chemical synthesis routes have been developed for ceramic and nanocomposite materials. The investigation shows that microemulsion and controlled growth processes followed by solvo-thermal treatment can be used for the preparation of agglomerate-free powders to be either incorporated into polymer matrices for nanocomposites or to be processed to ceramics. For obtaining green densities up to 60% by volume, appropriate surface modificati...

  9. An Application of Filtered Renewal Processes in Hydrology

    Directory of Open Access Journals (Sweden)

    Mario Lefebvre

    2014-01-01

    Full Text Available Filtered renewal processes are used to forecast daily river flows. For these processes, contrary to filtered Poisson processes, the time between consecutive events is not necessarily exponentially distributed, which is more realistic. The model is applied to obtain one- and two-day-ahead forecasts of the flows of the Delaware and Hudson Rivers, both located in the United States. Better results are obtained than with filtered Poisson processes, which are often used to model river flows.

  10. Monitoring of Welding Processes with Application of Artificial Neural Networks

    OpenAIRE

    Чвертко, Євгенія Петрівна; Пірумов, Андрій Євгенович; Шевченко, Микола Віталійович

    2014-01-01

    The paper presents a summary of methods of monitoring systems’ development for the processes involving heating of filler material and/ or base metal by the electric current and with periodical shortages of the welding circuit. The processes investigated were MAG welding, underwater flux-cored welding and flash-butt welding. Details of experiments, primary data processing procedures based on statistical analysis methods are described, the aim of primary processing being obtaining of informativ...

  11. Industrial applications of electrical discharge compaction process for powered metals

    Energy Technology Data Exchange (ETDEWEB)

    Yavuz, N.; Guellue, E.; Can, M. [Uludag Univ., Bursa (Turkey). Faculty for Engineering and Architecture

    2003-07-01

    Electrical discharge compaction which is a relatively new process combines the advantages of compacting metal powders and fast sintering. In this process, electrical energy stored in capacitors is discharged suddenly through metal powder columns contained in an electrically non-conducting container. It is a fast, cheap and reproducible process. (orig.)

  12. Principles of computer processing of Landsat data for geologic applications

    Science.gov (United States)

    Taranik, James V.

    1978-01-01

    The main objectives of computer processing of Landsat data for geologic applications are to improve display of image data to the analyst or to facilitate evaluation of the multispectral characteristics of the data. Interpretations of the data are made from enhanced and classified data by an analyst trained in geology. Image enhancements involve adjustments of brightness values for individual picture elements. Image classification involves determination of the brightness values of picture elements for a particular cover type. Histograms are used to display the range and frequency of occurrence of brightness values. Landsat-1 and -2 data are preprocessed at Goddard Space Flight Center (GSFC) to adjust for the detector response of the multispectral scanner (MSS). Adjustments are applied to minimize the effects of striping, adjust for bad-data lines and line segments and lost individual pixel data. Because illumination conditions and landscape characteristics vary considerably and detector response changes with time, the radiometric adjustments applied at GSFC are seldom perfect and some detector striping remain in Landsat data. Rotation of the Earth under the satellite and movements of the satellite platform introduce geometric distortions in the data that must also be compensated for if image data are to be correctly displayed to the data analyst. Adjustments to Landsat data are made to compensate for variable solar illumination and for atmospheric effects. GeoMetric registration of Landsat data involves determination of the spatial location of a pixel in. the output image and the determination of a new value for the pixel. The general objective of image enhancement is to optimize display of the data to the analyst. Contrast enhancements are employed to expand the range of brightness values in Landsat data so that the data can be efficiently recorded in a manner desired by the analyst. Spatial frequency enhancements are designed to enhance boundaries between features

  13. Mobile application for the support of CRM processes

    OpenAIRE

    Karimović, Mario

    2012-01-01

    Nowadays a mobile phone is an essential »instrument« of the modern man. It has become a loyal companion and a personal assistant of almost every person. That is why we chose to create a mobile application for our diploma thesis. This application will facilitate work for marketers, commercialists and all the people that require a simple and fast access to their clients’ data and business history for their work. With the help of this application they will have on overview of all current custome...

  14. Image-processing pipelines: applications in magnetic resonance histology

    Science.gov (United States)

    Johnson, G. Allan; Anderson, Robert J.; Cook, James J.; Long, Christopher; Badea, Alexandra

    2016-03-01

    Image processing has become ubiquitous in imaging research—so ubiquitous that it is easy to loose track of how diverse this processing has become. The Duke Center for In Vivo Microscopy has pioneered the development of Magnetic Resonance Histology (MRH), which generates large multidimensional data sets that can easily reach into the tens of gigabytes. A series of dedicated image-processing workstations and associated software have been assembled to optimize each step of acquisition, reconstruction, post-processing, registration, visualization, and dissemination. This talk will describe the image-processing pipelines from acquisition to dissemination that have become critical to our everyday work.

  15. THE DEVELOPMENT OF INSURANCE CONTRACT PROCESSING IN AN INSURANCE BUSSINESS APPLICATION

    OpenAIRE

    Vranešič, Primož

    2008-01-01

    Thesis includes presentation ov insurance bussiness application. The goal of it is to be used for processing insurance contracts. Aim of thesis is to present technologies and tools used in development of application with emphasis on technologies for data presentation Bussines application are important area of information technology. Their role is to automaticly process data. That allows a firm not to spend resources for manual data processing. All this increases productivity and cuts off ...

  16. Handbook of polymer nanocomposites processing, performance and application

    CERN Document Server

    Mohanty, Amar; Misra, Manjusri; Kar, Kamal K; Pandey, Jitendra; Rana, Sravendra; Takagi, Hitoshi; Nakagaito, Antonio; Kim, Hyun-Joong

    Volume A forms one volume of a Handbook about Polymer Nanocomposites. In some 20 chapters the preparation, architecture, characterisation, properties and application of polymer nanocomposites are discussed by experts in their respective fields.

  17. Semiconductor nanostructures for optoelectronic devices processing, characterization and applications

    CERN Document Server

    Yi, Gyu-Chul

    2012-01-01

    This book summarizes the current state of semiconductor nanodevice development, examining nanowires, nanorods, hybrid semiconductor nanostructures, wide bandgap nanostructures for visible light emitters and graphene and describing their device applications.

  18. Application of food irradiation processes to developing countries

    OpenAIRE

    Langerak, D.Is.; Cramwinckel, A.B.; Hollman, P.C.; Jong, de, P.; Labrijn, J.F.; Slangen, H.J.; Stegeman, H.; Veen, van der, A.; Wolters, Th.C.; Oortwijn, H.

    1986-01-01

    Sprouting of- and fungal attack on tuber, bulb and foot products is a common problem to most countries. Sprouting can be delayed by storage at low temperature, and partly prevented by a proper use of chemical sprout inhibitors. Cooling is, however, energy consuming, expensive and not practicabie everywhere. Chemicals are cheaper, but their application is not always reliable, especially at temperatures higher than 15'C. Moreover in some countries the application of chemical inhibitors is prohi...

  19. Novel application of DEM to modelling comminution processes

    Science.gov (United States)

    Delaney, Gary W.; Cleary, Paul W.; Sinnott, Matt D.; Morrison, Rob D.

    2010-06-01

    Comminution processes in which grains are broken down into smaller and smaller sizes represent a critical component in many industries including mineral processing, cement production, food processing and pharmaceuticals. We present a novel DEM implementation capable of realistically modelling such comminution processes. This extends on a previous implementation of DEM particle breakage that utilized spherical particles. Our new extension uses super-quadric particles, where daughter fragments with realistic size and shape distributions are packed inside a bounding parent super-quadric. We demonstrate the flexibility of our approach in different particle breakage scenarios and examine the effect of the chosen minimum resolved particle size. This incorporation of the effect of particle shape in the breakage process allows for more realistic DEM simulations to be performed, that can provide additional fundamental insights into comminution processes and into the behaviour of individual pieces of industrial machinery.

  20. Formalization of fUML: An Application to Process Verification

    OpenAIRE

    Laurent, Yoann; Bendraou, Reda; Baarir, Souheib; Gervais, Marie-Pierre

    2014-01-01

    International audience Much research work has been done on formalizing UML Ac-tivity Diagrams for process modeling to verify different kinds of sound-ness properties (deadlock, unreachable activities and so on) on process models. However, these works focus mainly on the control-flow aspects of the process and have done some assumptions on the precise execution semantics defined in natural language in the UML specification. In this paper, we define a first-order logic formalization of fUML ...

  1. The Mean Reversion Stochastic Processes Applications in Risk Management

    OpenAIRE

    Radkov, Petar

    2010-01-01

    In this study we investigate using the mean reversion processes in financial risk management, as they provide an good description of stock price uctuations and market risks. This paper does not aim at being exhaustive, but gives examples for practically implementable models allowing for stylised features in the data. After introducing several widely used the mean reversion processes, we discuss this methods for risk management with Monte Carlo simulations. We also explain how the process can ...

  2. Point processes in forestry : an application to tree crown detection

    OpenAIRE

    Perrin, Guillaume; Descombes, Xavier; Zerubia, Josiane

    2006-01-01

    In this research report, we aim at extracting tree crowns from remotely sensed images using marked point processes of discs and ellipses. Our approach is indeed to consider that the data are some realizations of a marked point process. Once a geometrical object is defined, we sample a marked point process defined by a density with a Reversible Jump Markov Chain Monte Carlo dynamics and simulated annealing to get the maximum a posteriori estimator of the tree crown distribution on the image. I...

  3. The Delphi process: a solution for reviewing novel grant applications

    OpenAIRE

    Robotin, Monica

    2010-01-01

    Cath Holliday1, Monica Robotin1,21Cancer Council New South Wales, Sydney; 2University of Sydney, School of Public Health, Sydney, New South Wales, AustraliaIntroduction: Traditional scientific review processes are not well suited for evaluating the merits of research in situations where the available scientific evidence is limited and if review panels have widely divergent opinions. This study tested whether a Delphi process is useful in grant selection.Materials and method: A Delphi process ...

  4. Spectral Image Processing with Applications in Biotechnology and Pathology

    OpenAIRE

    Gavrilovic, Milan

    2011-01-01

    Color theory was first formalized in the seventeenth century by Isaac Newton just a couple of decades after the first microscope was built. But it was not until the twentieth century that technological advances led to the integration of color theory, optical spectroscopy and light microscopy through spectral image processing. However, while the focus of image processing often concerns modeling of how images are perceived by humans, the goal of image processing in natural sciences and medicine...

  5. Development and Application of Heat-integrated Aromatics Fractionation Process

    Institute of Scientific and Technical Information of China (English)

    Yang Weisheng; Kong Dejin; Tan Yongzhong

    2009-01-01

    The PRO/Ⅱ process simulation software was applied to carry out simulated calculation of the aromatics frac-tionation unit and the heat integrated rectification process was proposed for the aromatics fractionation section of the 1.0 Mt/a toluene disproportionation unit at the Zhenhai Refining and Chemical Company. The optimized operating parameters were obtained through the energy utilization analysis, process simulation, heat exchanger calculations and comparisons of utility consumption. The operation of commercialized unit has revealed that the design parameters of each rectification column were consistent with the operation results, and the utility consumption was about 47% lower than the waditional heat integrated process.

  6. Affine diffusions and related processes simulation, theory and applications

    CERN Document Server

    Alfonsi, Aurélien

    2015-01-01

    This book gives an overview of affine diffusions, from Ornstein-Uhlenbeck processes to Wishart processes and it considers some related diffusions such as Wright-Fisher processes. It focuses on different simulation schemes for these processes, especially second-order schemes for the weak error. It also presents some models, mostly in the field of finance, where these methods are relevant and provides some numerical experiments. The book explains the mathematical background to understand affine diffusions and analyze the accuracy of the schemes.  

  7. Developing Friction Stir Welding Process Model for ICME Application

    Science.gov (United States)

    Yang, Yu-Ping

    2015-01-01

    A framework for developing a product involving manufacturing processes was developed with integrated computational materials engineering approach. The key component in the framework is a process modeling tool which includes a thermal model, a microstructure model, a thermo-mechanical, and a property model. Using friction stir welding (FSW) process as an example, development of the process modeling tool was introduced in detail. The thermal model and the microstructure model of FSW of steels were validated with the experiment data. The model can predict reasonable temperature and hardness distributions as observed in the experiment. The model was applied to predict residual stress and joint strength of a pipe girth weld.

  8. Teaching Process Effectiveness Model and Its Application at the University

    OpenAIRE

    Radosław Ryńca; Dorota Kuchta

    2010-01-01

    The article is taking the issues associated with the measurement of the teaching process effectiveness at the university. At the work authors modified model of the teaching effectiveness process presented by T. Chien in 2007. The article is also presented example of using the modified model.

  9. Mathematical modelling of anaerobic digestion processes: applications and future needs

    DEFF Research Database (Denmark)

    Batstone, Damien J.; Puyol, Daniel; Flores Alsina, Xavier;

    2015-01-01

    Anaerobic process modelling is a mature and well-established field, largely guided by a mechanistic model structure that is defined by our understanding of underlying processes. This led to publication of the IWA ADM1, and strong supporting, analytical, and extension research in the 15 years sinc...

  10. Recent applications of low energy electron beam processing

    International Nuclear Information System (INIS)

    It is obvious that radiation processing reduces energy consumption and avoids pollution because the coatings are solventless; but as important these factors may be, they alone do not justify the investment of an electron beam accelerator. With a few examples from the industry, motivations of users to choose electron processing is explained. (author)

  11. Integrating ICT applications for farm business collaboration processes using FIspace

    NARCIS (Netherlands)

    Kruize, J.W.; Wolfert, J.; Goense, D.; Scholten, H.; Beulens, A.J.M.; Veenstra, T.

    2014-01-01

    Agri-Food Supply Chain Networks are required to increase production and to be transparent while reducing environmental impact. This challenges farm enterprises to innovate their production processes. These processes need to be supported by advanced ICT components that are developed by multiple vendo

  12. Extending the applicability of the analytic hierarchy process

    NARCIS (Netherlands)

    Huizingh, K.R.E.; Vrolijk, H.C.J.

    1997-01-01

    The Analytic Hierarchy Process (AHP) has often been used to support decisions that only have to be made once. in this study, we explore whether the AHP can be applied to repetitive decision-making. We suggest a variant of the process to elicit implicit decision models that evaluate alternatives not

  13. Applications of Enzymes in Oil and Oilseed Processing

    DEFF Research Database (Denmark)

    Xu, Xuebing

    conventionally high temperature conditioning or cooking is necessary. The good story in industry is the fish oil and olive oil processing. Good quality and higher oil yield have been achieved through the use of enzymes in the processing stages. For the refining stage, the use of enzymes for degumming has......Enzymes, through the last 20-30 years research and development, have been widely explored for the uses in oil and oilseed processing. Following the conventional processing technology from oilseeds, the oil can be produced through pressing or solvent extraction. The crude oil is then refined to meet...... edible requirements. The oil can be also modified to meet functional or even nutritional needs. In each of those steps, enzymes have been used in industry successfully. For the oil processing stage, enzymes have been used to destroy the cell structure so that makes the oil release easier, where...

  14. Application of Process Modeling in a Software- Engineering Course

    Directory of Open Access Journals (Sweden)

    Gabriel Alberto García Mireles

    2001-11-01

    Full Text Available Coordination in a software development project is a critical issue in delivering a successful software product, within the constraints of time, functionality and budget agreed upon with the customer. One of the strategies for approaching this problem consists in the use of process modeling to document, evaluate, and redesign the software development process. The appraisal of the projects done in the Engineering and Methodology course of a program given at the Ensenada Center of Scientific Research and Higher Education (CICESE, from a process perspective, facilitated the identification of strengths and weaknesses in the development process used. This paper presents the evaluation of the practical portion of the course, the improvements made, and the preliminary results of using the process approach in the analysis phase of a software-development project.

  15. Modelling and estimating degradation processes with application in structural reliability

    International Nuclear Information System (INIS)

    The characteristic level of degradation of a given structure is modeled through a stochastic process called the degradation process. The random evolution of the degradation process is governed by a differential system with Markovian environment. We put the associated reliability framework by considering the failure of the structure once the degradation process reaches a critical threshold. A closed form solution of the reliability function is obtained thanks to Markov renewal theory. Then, we build an estimation methodology for the parameters of the stochastic processes involved. The estimation methods and the theoretical results, as well as the associated numerical algorithms, are validated on simulated data sets. Our method is applied to the modelling of a real degradation mechanism, known as crack growth, for which an experimental data set is considered. (authors)

  16. Fractional calculus with applications in mechanics vibrations and diffusion processes

    CERN Document Server

    Atanackovic, T; Stankovic, Bogoljub; Zorica , Dusan

    2014-01-01

    This book contains mathematical preliminaries in which basic definitions of fractional derivatives and spaces are presented. The central part of the book contains various applications in classical mechanics including fields such as: viscoelasticity, heat conduction, wave propagation and variational Hamilton-type principles. Mathematical rigor will be observed in the applications. The authors provide some problems formulated in the classical setting and some in the distributional setting. The solutions to these problems are presented in analytical form and these solutions are then analyzed num

  17. Molecular identification of CTX-M and blaOXY/K1 β-lactamase genes in Enterobacteriaceae by sequencing of universal M13-sequence tagged PCR-amplicons

    Directory of Open Access Journals (Sweden)

    Tärnberg Maria

    2009-01-01

    Full Text Available Abstract Background Plasmid encoded blaCTX-M enzymes represent an important sub-group of class A β-lactamases causing the ESBL phenotype which is increasingly found in Enterobacteriaceae including Klebsiella spp. Molecular typing of clinical ESBL-isolates has become more and more important for prevention of the dissemination of ESBL-producers among nosocomial environment. Methods Multiple displacement amplified DNA derived from 20 K. pneumoniae and 34 K. oxytoca clinical isolates with an ESBL-phenotype was used in a universal CTX-M PCR amplification assay. Identification and differentiation of blaCTX-M and blaOXY/K1 sequences was obtained by DNA sequencing of M13-sequence-tagged CTX-M PCR-amplicons using a M13-specific sequencing primer. Results Nine out of 20 K. pneumoniae clinical isolates had a blaCTX-M genotype. Interestingly, we found that the universal degenerated primers also amplified the chromosomally located K1-gene in all 34 K. oxytoca clinical isolates. Molecular identification and differentiation between blaCTX-M and blaOXY/K1-genes could only been achieved by sequencing of the PCR-amplicons. In silico analysis revealed that the universal degenerated CTX-M primer-pair used here might also amplify the chromosomally located blaOXY and K1-genes in Klebsiella spp. and K1-like genes in other Enterobacteriaceae. Conclusion The PCR-based molecular typing method described here enables a rapid and reliable molecular identification of blaCTX-M, and blaOXY/K1-genes. The principles used in this study could also be applied to any situation in which antimicrobial resistance genes would need to be sequenced.

  18. Design and Application of Economical Process Control Charts

    Directory of Open Access Journals (Sweden)

    S.S.N. Murthy

    1997-01-01

    Full Text Available Statistical quality control techniques are useful in monitoring the process behaviour. Attribute control charts are widely used in process control. The selection of sample size, sampling interval and control width of the control chart is important in minimising the quality costs. Control chart parameters, like 3delta controlimits and fixed fraction sampling at conveniently selected sampling intervals result in deplovable cost penalties in quality control. The best selection of these parameters depends on several process parameters,like frequency of occupancy of a shift in the process, cost of sampling, cost of investigation for finding assignable cause, probability of false alarms, penalty cost of defectives and process correction cost. A general model has been developed to determine the total quality cost as a function of these parameters. Probability of not identifying a process shift (Beeta-risk and probability of wrongly. concluding the process got shifted (alpha-risk are considered in developing the model. This cost equation is optimised to determine optimum values control chart parameters. Fibonacci search is used to quicken the analytical method or determining optimum sampling size and control width. The proposals made by Duncan, Montgomery, Gibra and Chiu for determining the optimum control chart parameters are critically examined and compared with the present model. Case studies were conducted in two foundries. Optimum control chart parameters in casting of cylinder liners and cast plates are determined. It has been found that quality costs are considerably reduced by using optimally designed control chart parameters with proposed method.

  19. Batch process. Application of CAE technique to a batch process; Bacchi purosesu eno CAE gijutsu no tenkai

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Y.; Nakai, K.; Oba, S. [Aspentic Japan Co. Ltd. (Japan)

    1997-09-05

    This paper introduces recent topics of the application of the CAE technique to a batch process. A batch distillation modeling tool (BATCHFRAC) is aimed at modeling a distillation tower and a batch reactor for a batch process for fine chemical products, and is provided as an expanded additional function for ASPEN FLUS batch distillation. A batch process designing system (BATCH PLUS) is a comprehensive batch process simulator for efficiently carrying out the designing, the development or the analysis of a complicated recipe-based batch process concerning medical treatment, biotechnology and agriculture. A batch process information control system (Batch/21) is provided as a system having an expanded and additional function for a batch process of InfoPlus/21, an information control system which enables the observation, management and controlling of a process. 4 figs.

  20. 7 CFR 1717.859 - Application process and timeframes.

    Science.gov (United States)

    2010-01-01

    ..., subtransmission, and headquarters facilities are submitted to the general field representative (GFR). The GFR will... application is satisfactory to the GFR, it will be sent promptly to the Washington office for further review... to the GFR. Procedures at this stage are the same as in paragraph (b)(1) of this section. (ii) If...

  1. Magnetostatic wave application to microwave analog signal processing

    Science.gov (United States)

    Degasperis, P.; Digregorio, C.; Miccoli, G.; Roveda, R.

    The physical principles underlying the operation of magnetostatic wave (MSW) devices are presented, and developments and applications are outlined. The technique promises direct handling at microwave frequencies (0.5 to 20 GHz) thanks to the control of the propagation of MSW in thin magnetic garnet films grown by liquid phase epitaxy.

  2. 76 FR 59863 - Application and Approval Process for New Programs

    Science.gov (United States)

    2011-09-27

    ... under the Higher Education Act of 1965, as amended (HEA), to streamline the application and approval... 600 Institutional Eligibility Under the Higher Education Act of 1965, as Amended We discuss... provides for the eligibility of institutions of higher education (20 U.S.C. 1099c). Current...

  3. Applications of quantum stochastic processes in quantum optics

    OpenAIRE

    Bouten, Luc

    2008-01-01

    These lecture notes provide an introduction to quantum filtering and its applications in quantum optics. We start with a brief introduction to quantum probability, focusing on the spectral theorem. Then we introduce the conditional expectation and quantum stochastic calculus. In the last part of the notes we discuss the filtering problem.

  4. 76 FR 22448 - Delays in Processing of Special Permits Applications

    Science.gov (United States)

    2011-04-21

    ...-N Billings Flying Service, Inc., 4 06-30-2011 Billings, MT. 15164-N Alaska Juneau Aeronautics, 4 05... in association with each identified application. FOR FURTHER INFORMATION CONTACT: Delmer F. Billings... 15251-N Suburban Air Freight, Inc., 4 06-30-2011 Omaha, NE. BILLING CODE 4910-60-M...

  5. 7 CFR 273.2 - Office operations and application processing.

    Science.gov (United States)

    2010-01-01

    ... cooperation. (1) To determine eligibility, the application form must be completed and signed, the household or... nonhousehold members under § 273.1(b)(2) as individuals outside the household. (2) Cooperation with QC Reviewer.... Where the Interim Guidance and the DOJ final rule conflict, the latter should control the...

  6. Application of the Kelly Criterion to Ornstein-Uhlenbeck Processes

    Science.gov (United States)

    Lv, Yingdong; Meister, Bernhard K.

    In this paper, we study the Kelly criterion in the continuous time framework building on the work of E.O. Thorp and others. The existence of an optimal strategy is proven in a general setting and the corresponding optimal wealth process is found. A simple formula is provided for calculating the optimal portfolio for a set of price processes satisfying some simple conditions. Properties of the optimal investment strategy for assets governed by multiple Ornstein-Uhlenbeck processes are studied. The paper ends with a short discus-sion of the implications of these ideas for financial markets.

  7. Application of high magnetic fields in advanced materials processing

    Institute of Scientific and Technical Information of China (English)

    MA Yanwei; XIAO Liye; YAN Luguang

    2006-01-01

    Recently, steady magnetic fields available from cryogen-free superconducting magnets open up new ways to process materials. In this paper,the main results obtained by using a high magnetic field to process several advanced materials are reviewed. These processed objects primarily include superconducting, magnetic, metallic and nanometer-scaled materials. It has been found that a high magnetic field can effectively align grains when fabricating the magnetic and non-magnetic materials and make inclusions migrate in a molten metal. The mechanism is discussed from the theoretical viewpoint of magnetization energy.

  8. Tutorial for mixture-process experiments with an industrial application

    Directory of Open Access Journals (Sweden)

    Luiz Henrique Abreu Dal Bello

    2011-12-01

    Full Text Available This article presents a tutorial on mixture-process experiments and a case study of a chemical compound used in the delay mechanism for starting a rocket engine. The compound consists in a three-component mixture. Besides the mixture components, two process variables are considered. For the model selection, the use of an information criterion showed to be efficient in the case under study. A linear regression model was fitted. Through the developed model, the optimal proportions of the mixture components and the levels of the process variables were determined.

  9. The Application of Laser Processing on Clutch Manufacture

    Institute of Scientific and Technical Information of China (English)

    ZHU Qigen

    2006-01-01

    The first multi-function laser processing system in the domestic for clutch manufacture, with abilities of cutting, jointing and heat treatment, was reported in this paper. One external optical path, double laser heads, adjust device by manual operation, automatically track were employed in this system. Also the other parts of vehicles can be fabricated by this system, as well as clutches. The special processing to manufacture the clutches of heavy vehicles, which was developed by the project of this laser processing system, achieved the international standards and satisfied the economic development and nation defense in the domestic.

  10. 40 CFR 408.150 - Applicability; description of the fish meal processing subcategory.

    Science.gov (United States)

    2010-07-01

    ... meal processing subcategory. 408.150 Section 408.150 Protection of Environment ENVIRONMENTAL PROTECTION... CATEGORY Fish Meal Processing Subcategory § 408.150 Applicability; description of the fish meal processing... menhaden on the Gulf and Atlantic Coasts and the processing of anchovy on the West Coast into fish...

  11. Reaming process improvement and control: An application of statistical engineering

    DEFF Research Database (Denmark)

    Müller, Pavel; Genta, G.; Barbato, G.;

    2012-01-01

    A reaming operation had to be performed within given technological and economical constraints. Process improvement under realistic conditions was the goal of a statistical engineering project, supported by a comprehensive experimental investigation providing detailed information on single...

  12. Assessment of very high-temperature reactors in process applications

    Energy Technology Data Exchange (ETDEWEB)

    Spiewak, I.; Jones, J.E. Jr.; Gambill, W.R.; Fox, E.C.

    1976-11-01

    An overview is presented of the technical and economic feasibility for the development of a very high-temperature reactor (VHTR) and associated processes. A critical evaluation of VHTR technology for process temperatures of 1400 and 2000/sup 0/F is made. Additionally, an assessment of potential market impact is made to determine the commercial viability of the reactor system. It is concluded that VHTR process heat in the range of 1400 to 1500/sup 0/F is attainable with near-term technology. However, process heat in excess of 1600/sup 0/F would require considerably more materials development. The potential for the VHTR could include a major contribution to synthetic fuel, hydrogen, steel, and fertilizer production and to systems for transport and storage of high-temperature heat. A recommended development program including projected costs is presented.

  13. Titanium alloys. Advances in alloys, processes, products and applications

    OpenAIRE

    Blenkinsop, P.

    1993-01-01

    The last few years have been a period of consolidation of existing alloys and processes. While the aerospace industry remains the principal driving force for alloy development, the paper illustrates examples of new markets being established in "older" alloys, by a combination of product/process development and a re-examination of engineering design parameters. Considerable attention is still being directed towards the titanium aluminide systems, but other more conventional alloy developments ...

  14. Data reconciliation and gross error detection: application in chemical processes

    OpenAIRE

    EGHBAL AHMADİ, Mohammad Hosein

    2015-01-01

    Abstract. Measured data are normally corrupted by different kinds of errors in many chemical processes. In this work, a brief overview in data reconciliation and gross error detection believed as the most efficient technique in reducing the measurement errors and obtaining accurate information about the process is presented. In addition to defining the basic problem and a survey of recent developments in this area that is categorized in “Real Time Optimization” field, we will describe about a...

  15. An Application of Lean Thinking to the Furniture Engineering Process

    OpenAIRE

    Wang, Chao

    2011-01-01

    Efficient engineering processes are critically important for furniture manufacturers. Engineering impacts the production cost, design quality, product lead time, and customer satisfaction. This research presents a systematic approach to analyze a furniture engineering process through a case study. The research was conducted through a case study in a furniture plant located in China, producing American style furniture products. The first stage was to investigate the companyâ s current enginee...

  16. Application of Mellin Transform in Wideband Underwater Acoustic Signal Processing

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    According to the features of the wideband underwater acoustic signals, an algorithm for the wideband ambiguity function is put forward based on Mellin transform. The wideband acoustic signal processing using the fast Mellin transform is also explored. The theoretical analysis and simulation results show that the algorithm has not only high computation efficiency but also good concentration in wideband ambiguity domain. It suits for the wideband underwater acoustic signal processing.

  17. An expert systems application to space base data processing

    Science.gov (United States)

    Babb, Stephen M.

    1988-01-01

    The advent of space vehicles with their increased data requirements are reflected in the complexity of future telemetry systems. Space based operations with its immense operating costs will shift the burden of data processing and routine analysis from the space station to the Orbital Transfer Vehicle (OTV). A research and development project is described which addresses the real time onboard data processing tasks associated with a space based vehicle, specifically focusing on an implementation of an expert system.

  18. An Evaluation Methodology Development and Application Process for Severe Accident Safety Issue Resolution

    OpenAIRE

    Martin, Robert P.

    2012-01-01

    A general evaluation methodology development and application process (EMDAP) paradigm is described for the resolution of severe accident safety issues. For the broader objective of complete and comprehensive design validation, severe accident safety issues are resolved by demonstrating comprehensive severe-accident-related engineering through applicable testing programs, process studies demonstrating certain deterministic elements, probabilistic risk assessment, and severe accident management...

  19. 32 CFR Appendix A to Part 284 - Overview of Waiver Application Process

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Overview of Waiver Application Process A Appendix A to Part 284 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF... ALLOWANCES Pt. 284, App. A Appendix A to Part 284—Overview of Waiver Application Process A. Standards...

  20. 78 FR 79703 - Submission for OMB Review; 30-Day Comment Request: Application Process for Clinical Research...

    Science.gov (United States)

    2013-12-31

    ...: Application Process for Clinical Research Training and Medical Education at the Clinical Center and Its Impact... in writing. Proposed Collection: Application Process for Clinical Research Training and Medical... Clinical Research Training and Medical Education, NIH Clinical Center, 10 Center Drive, MSC 1158,...

  1. 40 CFR 406.60 - Applicability; description of the parboiled rice processing subcategory.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Applicability; description of the parboiled rice processing subcategory. 406.60 Section 406.60 Protection of Environment ENVIRONMENTAL... Rice Processing Subcategory § 406.60 Applicability; description of the parboiled rice...

  2. 47 CFR 74.1233 - Processing FM translator and booster station applications.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Processing FM translator and booster station... SERVICES FM Broadcast Translator Stations and FM Broadcast Booster Stations § 74.1233 Processing FM translator and booster station applications. (a) Applications for FM translator and booster stations...

  3. Characterization of shallow trench isolation CMP process and its application

    Science.gov (United States)

    Li, Helen; Zhang, ChunLei; Liu, JinBing; Liu, ZhengFang; Chen, Kuang Han; Gbondo-Tugbawa, Tamba; Ding, Hua; Li, Flora; Lee, Brian; Gower-Hall, Aaron; Chiu, Yang-Chih

    2016-03-01

    Chemical mechanical polishing (CMP) has been a critical enabling technology in shallow trench isolation (STI), which is used in current integrated circuit fabrication process to accomplish device isolation. Excessive dishing and erosion in STI CMP processes, however, create device yield concerns. This paper proposes characterization and modeling techniques to address a variety of concerns in STI CMP. In the past, majority of CMP publications have been addressed on interconnect layers in backend- of-line (BEOL) process. However, the number of CMP steps in front-end-of-line (FEOL) has been increasing in more advanced process techniques like 3D-FinFET and replacement metal gate, as a results incoming topography induced by FEOL CMP steps can no longer be ignored as the topography accumulates and stacks up across multiple CMP steps and eventually propagating to BEOL layers. In this paper, we first discuss how to characterize and model STI CMP process. Once STI CMP model is developed, it can be used for screening design and detect possible manufacturing weak spots. We also work with process engineering team to establish hotspot criteria in terms of oxide dishing and nitride loss. As process technologies move from planar transistor to 3D transistor like FinFet and multi-gate, it is important to accurately predict topography in FEOL CMP processes. These incoming topographies when stacked up can have huge impact in BEOL copper processes, where copper pooling becomes catastrophic yield loss. A calibration methodology to characterize STI CMP step is developed as shown in Figure 1; moreover, this STI CMP model is validated from silicon data collected from product chips not used in calibration stage. Additionally, wafer experimental setup and metrology plan are instrumental to an accurate model with high predictive power. After a model is generated, spec limits and threshold to establish hotspots criteria can be defined. Such definition requires working closely with foundry

  4. 8th International Conference on Robotic, Vision, Signal Processing & Power Applications

    CERN Document Server

    Mustaffa, Mohd

    2014-01-01

    The proceeding is a collection of research papers presented, at the 8th International Conference on Robotics, Vision, Signal Processing and Power Applications (ROVISP 2013), by researchers, scientists, engineers, academicians as well as industrial professionals from all around the globe. The topics of interest are as follows but are not limited to: • Robotics, Control, Mechatronics and Automation • Vision, Image, and Signal Processing • Artificial Intelligence and Computer Applications • Electronic Design and Applications • Telecommunication Systems and Applications • Power System and Industrial Applications  

  5. Metabolic processes of Methanococcus maripaludis and potential applications

    OpenAIRE

    Goyal, Nishu; Zhou, Zhi; Karimi, Iftekhar A.

    2016-01-01

    Methanococcus maripaludis is a rapidly growing, fully sequenced, genetically tractable model organism among hydrogenotrophic methanogens. It has the ability to convert CO2 and H2 into a useful cleaner energy fuel (CH4). In fact, this conversion enhances in the presence of free nitrogen as the sole nitrogen source due to prolonged cell growth. Given the global importance of GHG emissions and climate change, diazotrophy can be attractive for carbon capture and utilization applications from appr...

  6. Radiotracers applications for industrial troubleshooting and process optimization

    International Nuclear Information System (INIS)

    The radiotracer techniques are well established and widely used for detection of blockages and leaks in different systems, residence time distribution investigations, mixing studies, corrosion measurements, efficient management of oil wells and management of ports. In most of the situations they do not have any equivalent and competing alternatives. High economic benefits are achieved from the application of the radiotracer techniques to leak detection and location

  7. Investigation of plasma processes in surface Modification with biodiagnostic applications

    OpenAIRE

    Coyle, Conor

    2012-01-01

    Plasma enhanced chemical vapour deposition was investigated for the deposition of bioactive surfaces which can be categorised into two functions. The first is in biosensor applications, immunoassay biodevices have been researched considerably but significant problems remain in particular non-specific adsorption. This work demonstrates a new method of reducing the non specific adsorption on the surface of cyclo olefin polymers for use as immunoassay biodevices. PECVD deposition of a silico...

  8. Parallel processing numerical method for confined vortex dynamics and applications

    Science.gov (United States)

    Bistrian, Diana Alina

    2013-10-01

    This paper explores a combined analytical and numerical technique to investigate the hydrodynamic instability of confined swirling flows, with application to vortex rope dynamics in a Francis turbine diffuser, in condition of sophisticated boundary constraints. We present a new approach based on the method of orthogonal decomposition in the Hilbert space, implemented with a spectral descriptor scheme in discrete space. A parallel implementation of the numerical scheme is conducted reducing the computational time compared to other techniques.

  9. Marginal standardization of upper semicontinuous processes. With application to max-stable processes

    OpenAIRE

    Sabourin, Anne; Segers, Johan

    2016-01-01

    In the field of spatial extremes, stochastic processes with upper semicontinuous (usc) trajectories have been proposed as random shape functions for max-stable models. In the literature dealing with usc processes, max-stability is defined via a sequences of scaling constants, rather than functions, only. It is however not clear whether and how extreme-value theory (EVT) for continuous processes extends to usc processes. In particular, classical multivariate and continuous EVT relies on the pr...

  10. Simulation and Data Processing for Ultrasonic Phased-Arrays Applications

    Science.gov (United States)

    Chaffaï-Gargouri, S.; Chatillon, S.; Mahaut, S.; Le Ber, L.

    2007-03-01

    The use of phased-arrays techniques has considerably contributed to extend the domain of applications and the performances of ultrasonic methods on complex configurations. Their adaptability offers a great freedom for conceiving the inspection leading to a wide range of functionalities gathering electronic commutation, applications of different delay laws and so on. This advantage allows to circumvent the difficulties encountered with more classical techniques especially when the inspection is assisted by simulation at the different stages : probe design (optimization of the number and characteristics of the elements), evaluation of the performances in terms of flaw detection (zone coverage) and characterization, driving the array (computation of adapted delay laws) and finally analyzing the results (versatile model-based imaging tools allowing in particular to locate the data in the real space). The CEA is strongly involved in the development of efficient simulation-based tools adapted to these needs. In this communication we present the recent advances done at CEA in this field and show several examples of complex NDT phased arrays applications. On these cases we show the interest and the performances of simulation-helped array design, array-driving and data analysis.

  11. Process heat in petroleum refinery applications. Final report

    International Nuclear Information System (INIS)

    The results of a study to evaluate the use of the General Atomic high-temperature gas-cooled reactor as a heat source for petroleum refining and other petrochemical processes requiring process temperatures up to 10500F are presented. The specific objective was to investigate methods of supplying and transporting steam and process heat from the primary reactor coolant to the refinery process heat exchangers. An evaluation of potential heat transfer fluids for transporting the heat from the reactor site to the refinery site was made and a promising fluid was selected for further investigation. A conceptual design of a secondary helium heat transfer loop with a heat exchanger located inside the prestressed concrete reactor vessel was established. Methods for providing minimum acceptable process heat and steam during reactor refueling and shutdown were investigated. A safety evaluation considering the possibility and consequences of radioactive contamination and petroleum contamination of the heat transfer fluid was conducted. The necessary modifications to the nuclear reactor system were identified and conceptual designs and economic estimates for these modifications were made

  12. Are classical process safety concepts relevant to nanotechnology applications?

    International Nuclear Information System (INIS)

    The answer to the question posed by the title of this paper is yes - with adaptation to the specific hazards and challenges found in the field of nanotechnology. The validity of this affirmative response is demonstrated by relating key process safety concepts to various aspects of the nanotechnology industry in which these concepts are either already practised or could be further applied. This is accomplished by drawing on the current author's experience in process safety practice and education as well as a review of the relevant literature on the safety of nanomaterials and their production. The process safety concepts selected for analysis include: (i) risk management, (ii) inherently safer design, (iii) human error and human factors, (iv) safety management systems, and (v) safety culture.

  13. Low cost lift-off process optimization for MEMS applications

    Science.gov (United States)

    Pandey, Shilpi; Bansal, Deepak; Panwar, Deepak; Shukla, Neha; Kumar, Arvind; Kothari, Prateek; Verma, Seema; Rangra, K. J.

    2016-04-01

    The patterning of thin films play major role in the performance of MEMS devices. The wet etching gives an isotropic profile and etch rate depends on the temperature, size of the microstructures and repetitive use of the solution. Even with the use of selective etchants, it significantly attacks the underlying layer. On the other side, dry etching is expensive process. In this paper, double layer of photoresist is optimized for lift-off process. Double layer lift-off technique offers process simplicity, low cost, over conventional single layer lift-off or bilayer lift-off with LOR. The problem of retention and flagging is resolved. The thickness of double coat photoresist is increased by 2.3 times to single coat photo resist.

  14. Application of Computer Simulation Modeling to Medication Administration Process Redesign

    Directory of Open Access Journals (Sweden)

    Nathan Huynh

    2012-01-01

    Full Text Available The medication administration process (MAP is one of the most high-risk processes in health care. MAP workflow redesign can precipitate both unanticipated and unintended consequences that can lead to new medication safety risks and workflow inefficiencies. Thus, it is necessary to have a tool to evaluate the impact of redesign approaches in advance of their clinical implementation. This paper discusses the development of an agent-based MAP computer simulation model that can be used to assess the impact of MAP workflow redesign on MAP performance. The agent-based approach is adopted in order to capture Registered Nurse medication administration performance. The process of designing, developing, validating, and testing such a model is explained. Work is underway to collect MAP data in a hospital setting to provide more complex MAP observations to extend development of the model to better represent the complexity of MAP.

  15. Research and Applications of Semi-solid Processing

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    It has been more than ten years since the semi-solid processing (SSP) technique was put into commercial ap plications in the world. A lot of work on semi-solid metals (SSM) including their preparation, reheating and semi-solid forming has been done in China. In order to produce the high quality die-casting, a novel innovation that modifies the present machines based on the SSP technique was proposed. Semi-solid die-casting on modified casting machines can manufacture parts with more excellent quality than those produced by squeeze casting. It was found that the defects such as "elephant foot" and "periphery liquid metal loss" during reheating could be avoided through controlling the non-de ndritic structure of billets and optimizing the reheating process. The processing parameters and mold designs of semi-so lid die-casting are fairly different from those of liquid die-casting.

  16. Application of wavelet analysis to crustal deformation data processing

    Institute of Scientific and Technical Information of China (English)

    张燕; 吴云; 刘永启; 施顺英

    2004-01-01

    The time-frequency analysis and anomaly detection of wavelet transformation make the method irresistibly advantageous in non-stable signal processing. In the paper, the two characteristics are analyzed and demonstrated withsynthetic signal. By applying wavelet transformation to deformation data processing, we find that about 4 monthsbefore strong earthquakes, several deformation stations near the epicenter received at the same time the abnormalsignal with the same frequency and the period from several days to more than ten days. The GPS observation stations near the epicenter all received the abnormal signal whose period is from 3 months to half a year. These abnormal signals are possibly earthquake precursors.

  17. Application of artificial intelligence techniques in the engineering design process

    International Nuclear Information System (INIS)

    The proposed paper gives a proof of concept of the fact that, currently available techniques for handling non-algorithmic problems by computers can be successfully applied to partially automate the decision making processes in the engineering design synthesis. Several small expert systems have been developed for helping a novice engineer to perform finite-element analyses of various structural elements. The expert systems guide the novice through such processes as setting the boundary conditions, choice of materials and suggest changes in initial design to achieve the desired product. (author)

  18. Application of ionizing radiation in food and feeds processing

    International Nuclear Information System (INIS)

    The seminar heard 8 papers whose topics were: safeguarding the development and testing of RIA kits for veterinary medicine; radicidation of fish meal; effects of radiosterilization on changes in vitamin A content in different fats in mixtures with cereals; technology of radiation processing of feed mixtures and litter for laboratory animals; methods of determining radiation processing of onions; operation of industrial irradiation plant GBZ 81 near Leipzig used for the radurization of onions; replacement of pesticides with radiation disinfestation; radiation sources for irradiation of foods and feeds. (J.P.)

  19. Use of ionising radiation for food processing applications

    International Nuclear Information System (INIS)

    Food irradiation is a recently developed technique used to sterilize and preserve food. Food products are exposed to ionising radiations such as X-rays, gamma rays or high energy electrons which destroy food borne pathogens and parasites and inhibit sprouting. Shelf life of food is extended. The following aspects of radiation processing of food are discussed in the monograph: radiation sources, choice of dose for specific results, safety and nutritional quality of radiation processed food, international status of acceptance of food irradiation, and cost. (M.G.B.). 6 tabs

  20. Signal processing in magnetic resonance spectroscopy with biomedical applications

    CERN Document Server

    Belkic, Dzevad

    2010-01-01

    ""a useful addition to the fields of both magnetic resonance (MR) as well as signal processing. … immensely useful as a practical resource handbook to dip into from time to time and to find specific advice on issues faced during the course of work in MR techniques for cancer research. … the best feature of this book is how it positions the very practical area of digital signal processing in the contextual framework of a much more esoteric and fundamental field-that of quantum mechanics. The direct link between quantum-mechanical spectral analysis and rational response functions and the gene

  1. Glow discharge assisted oxynitriding process of titanium for medical application

    Science.gov (United States)

    Wierzchoń, Tadeusz; Czarnowska, Elżbieta; Grzonka, Justyna; Sowińska, Agnieszka; Tarnowski, Michał; Kamiński, Janusz; Kulikowski, Krzysztof; Borowski, Tomasz; Kurzydłowski, Krzysztof J.

    2015-04-01

    The plasma oxynitriding process is a prospective method of producing titanium oxides as an integral part of a diffusive nitrided surface layer on titanium implants. This hybrid process, which combines glow discharge assisted nitriding and oxidizing, permits producing TiO2 + Ti2N + αTi(N)-type diffusive surface layers. The oxynitrided surface layers improve the corrosion and wear resistance of the substrate material. Additionally, the nanocrystalline titanium oxide TiO2 (rutile) improves the biological properties of titanium and its alloys when in contact with blood, whereas the TiN + Ti2N + αTi(N) zone eliminates the effect of metalosis.

  2. Self-piercing riveting properties, processes and applications

    CERN Document Server

    Chrysanthou, A

    2014-01-01

    Due to its speed, low energy requirements, and the fact that it does not require a pre-drilled hole, the technique of self-piercing riveting (SPR) has been increasingly adopted by many industries as a high-speed mechanical fastening technique for the joining of sheet material components. Self-piercing riveting comprehensively reviews the process, equipment, and corrosion behaviour of self-piercing riveting, and also describes the process of evaluation and modelling of strength of self-piercing riveted joints, quality control methods and non-destructive testing.Part one provides an exte

  3. Application of Wavelet Techniques in ECG Signal Processing: An Overview

    Directory of Open Access Journals (Sweden)

    Nagendra H

    2011-10-01

    Full Text Available ECG signals are non-stationary, pseudo periodic in nature and whose behavior changes with time. The proper processing of ECG signal and its accurate detection is very much essential since it determines thecondition of the heart. The analysis of ECG signal requires the information both in time and frequency, for clinical diagnosis. Hence the wavelet transforms becomes handy for analyzing these types of the signals. In this paper we have given an overview of some wavelet techniques published in journals and conferences since 2005 onwards for processing the ECG and also we have compared the performance, advantages and limitations of these techniques.

  4. The application of a linear electron accelerator in radiation processing

    Science.gov (United States)

    Ruiying, Zhou; Binglin, Wang; Wenxiu, Chen; Yongbao, Gu; Yinfen, Zhang; Simin, Qian; Andong, Liu; Peide, Wang

    A 3-5 MeV electron beam generated by a BF-5 type linear electron accelerator has been used in some radiation processing works, such as, (1) The cross-linking technology by radiation for the polyethylene foaming processing --- the correlation between the cross-linkage and the absorbed dose, the relation between the elongation of foaming polyethylene and the dose, the relation between the size of the cavities and the gelatin rate and the optimum range of dosage for foaming have been found. (2) The research work on the fast switch thyristor irradiated by electron beam --- The relation between the absorbed dose and the life-time of minority carriers has been studied and the optimum condition for radiation processing was determined. This process is much better than the conventional gold diffusion in raising the quality and end-product rate of these devices. Besides, we have made some testing works on the hereditary mutation of plant seeds and microorganism mutation induced by electron radiation and radiation sterilization for some medical instruments and foods.

  5. Natural processes in delta restoration: application to the Mississippi Delta.

    Science.gov (United States)

    Paola, Chris; Twilley, Robert R; Edmonds, Douglas A; Kim, Wonsuck; Mohrig, David; Parker, Gary; Viparelli, Enrica; Voller, Vaughan R

    2011-01-01

    Restoration of river deltas involves diverting sediment and water from major channels into adjoining drowned areas, where the sediment can build new land and provide a platform for regenerating wetland ecosystems. Except for local engineered structures at the points of diversion, restoration mainly relies on natural delta-building processes. Present understanding of such processes is sufficient to provide a basis for determining the feasibility of restoration projects through quantitative estimates of land-building rates and sustainable wetland area under different scenarios of sediment supply, subsidence, and sea-level rise. We are not yet to the point of being able to predict the evolution of a restored delta in detail. Predictions of delta evolution are based on field studies of active deltas, deltas in mine-tailings ponds, experimental deltas, and countless natural experiments contained in the stratigraphic record. These studies provide input for a variety of mechanistic delta models, ranging from radially averaged formulations to more detailed models that can resolve channels, topography, and ecosystem processes. Especially exciting areas for future research include understanding the mechanisms by which deltaic channel networks self-organize, grow, and distribute sediment and nutrients over the delta surface and coupling these to ecosystem processes, especially the interplay of topography, network geometry, and ecosystem dynamics. PMID:21329199

  6. Functional Analytic Psychotherapy for Interpersonal Process Groups: A Behavioral Application

    Science.gov (United States)

    Hoekstra, Renee

    2008-01-01

    This paper is an adaptation of Kohlenberg and Tsai's work, Functional Analytical Psychotherapy (1991), or FAP, to group psychotherapy. This author applied a behavioral rationale for interpersonal process groups by illustrating key points with a hypothetical client. Suggestions are also provided for starting groups, identifying goals, educating…

  7. Asymmetric skew Bessel processes and their applications to finance

    NARCIS (Netherlands)

    M. Decamps; M.J. Goovaerts; W. Schoutens

    2006-01-01

    In this paper, we extend the Harrison and Shepp's construction of the skew Brownian motion (1981) and we obtain a diffusion similar to the two-dimensional Bessel process with speed and scale densities discontinuous at one point. Natural generalizations to multi-dimensional and fractional order Besse

  8. Nonlinear Optical Signal Processing for Tbit/s Ethernet Applications

    DEFF Research Database (Denmark)

    Oxenløwe, Leif Katsuo; Galili, Michael; Mulvad, Hans Christian Hansen;

    2012-01-01

    We review recent experimental demonstrations of Tbaud optical signal processing. In particular, we describe a successful 1.28 Tbit/s serial data generation based on single polarization 1.28 Tbaud symbol rate pulses with binary data modulation (OOK) and subsequent all-optical demultiplexing. We also...

  9. The Development and Application of an Integrated VAR Process Model

    Science.gov (United States)

    Ballantyne, A. Stewart

    2016-07-01

    The VAR ingot has been the focus of several modelling efforts over the years with the result that the thermal regime in the ingot can be simulated quite realistically. Such models provide important insight into solidification of the ingot but present some significant challenges to the casual user such as a process engineer. To provide the process engineer with a tool to assist in the development of a melt practice, a comprehensive model of the complete VAR process has been developed. A radiation heat transfer simulation of the arc has been combined with electrode and ingot models to develop a platform which accepts typical operating variables (voltage, current, and gap) together with process parameters (electrode size, crucible size, orientation, water flow, etc.) as input data. The output consists of heat flow distributions and solidification parameters in the form of text, comma-separated value, and visual toolkit files. The resulting model has been used to examine the relationship between the assumed energy distribution in the arc and the actual energy flux which arrives at the ingot top surface. Utilizing heat balance information generated by the model, the effects of electrode-crucible orientation and arc gap have been explored with regard to the formation of ingot segregation defects.

  10. BUSINESS PROCESS IMPROVEMENT APPLICATION OF MODERN MANAGEMENT TECHNIQUES

    OpenAIRE

    Marija Zivanovic, Nada Zivanovic

    2015-01-01

    Today, globally operating business world is exposed to constant change processes. Reengineering is the driving force that helps companies, business and manufacturing organizations to achieve success in the new millennium that is full of challenges, risks, information explosion, Internet communications, teleconferencing and global competition. Therefore, effective business strategy, well-trained management personnel, financial - tech resources (IT), management skills and the skills and flexibi...

  11. Markov Skeleton Processes and Applications to Queueing Systems

    Institute of Scientific and Technical Information of China (English)

    Zhen-ting Hou

    2002-01-01

    In this paper, we apply the backward equations of Markov skeleton processes to queueing systems.The transient distribution of the waiting time of a GI/G/1 queueing system, the transient distribution of the length of a GI/G/N queueing system and the transient distribution of the length of queueing networks are obtained.

  12. The Application of Partial Differential Equations in Medical Image Processing

    Directory of Open Access Journals (Sweden)

    Mohammad Madadpour Inallou

    2013-10-01

    Full Text Available Mathematical models are the foundation of biomedical computing. Partial Differential Equations (PDEs in Medical Imaging is concerned with acquiring images of the body for research, diagnosis and treatment. Biomedical Image Processing and its influence has undergoing a revolution in the past decade. Image processing has become an important component in contemporary science and technology and has been an interdisciplinary research field attracting expertise from applied mathematics, biology, computer sciences, engineering, statistics, microscopy, radiologic sciences, physics, medicine and etc. Medical imaging equipment is taking on an increasingly critical role in healthcare as the industry strives to lower patient costs and achieve earlier disease prediction using noninvasive means. The subsections of medical imaging are categorized to two: Conventional (X-Ray and Ultrasound and Computed (CT, MRI, fMRI, SPECT, PET and etc. This paper is organized as fallow: First section describes some kind of image processing. Second section is about techniques and requirements, and in the next sections the proceeding of Analyzing, Smoothing, Segmentation, De-noising and Registration in Medical Image Processing Equipment by PDEs Framework will be regarded

  13. Applicability of vector processing to large-scale nuclear codes

    International Nuclear Information System (INIS)

    To meet the growing trend of computational requirements in JAERI, introduction of a high-speed computer with vector processing faculty (a vector processor) is desirable in the near future. To make effective use of a vector processor, appropriate optimization of nuclear codes to pipelined-vector architecture is vital, which will pose new problems concerning code development and maintenance. In this report, vector processing efficiency is assessed with respect to large-scale nuclear codes by examining the following items: 1) The present feature of computational load in JAERI is analyzed by compiling the computer utilization statistics. 2) Vector processing efficiency is estimated for the ten heavily-used nuclear codes by analyzing their dynamic behaviors run on a scalar machine. 3) Vector processing efficiency is measured for the other five nuclear codes by using the current vector processors, FACOM 230-75 APU and CRAY-1. 4) Effectiveness of applying a high-speed vector processor to nuclear codes is evaluated by taking account of the characteristics in JAERI jobs. Problems of vector processors are also discussed from the view points of code performance and ease of use. (author)

  14. Microwave Field Applicator Design in Small-Scale Chemical Processing

    NARCIS (Netherlands)

    Sturm, G.S.J.

    2013-01-01

    Ever since the first experiments nearly three decades ago, microwave enhanced chemistry has received incessant scientific attention. Many studies report improved process performance in terms of speed and conversion under microwave exposure and therefore it is recognized as a promising alternative me

  15. Application of a medical image processing system in liver transplantation

    Institute of Scientific and Technical Information of China (English)

    Chi-Hua Fang; Xiao-Feng Li; Zhou Li; Ying-Fang Fan; Chao-Min Lu; Yan-Peng Huang; Feng-Ping Peng

    2010-01-01

    BACKGROUND: At present, imaging is used not only to show the form of images, but also to make three-dimensional (3D) reconstructions and visual simulations based on original data to guide clinical surgery. This study aimed to assess the use of a medical image-processing system in liver transplantation surgery. METHODS: The data of abdominal 64-slice spiral CT scan were collected from 200 healthy volunteers and 37 liver cancer patients in terms of hepatic arterial phase, portal phase, and hepatic venous phase. A 3D model of abdominal blood vessels including the abdominal aorta system, portal vein system, and inferior vena cava system was reconstructed by an abdominal image processing system to identify vascular variations. Then, a 3D model of the liver was reconstructed in terms of hepatic segmentation and liver volume was calculated. The FreeForm modeling system with a PHANTOM force feedback device was used to simulate the real liver transplantation environment, in which the total process of liver transplantation was completed. RESULTS: The reconstructed model of the abdominal blood vessels and the liver was clearly demonstrated to be three-dimensionally consistent with the anatomy of the liver, in which the variations of abdominal blood vessels were identiifed and liver segmentation was performed digitally. In the model, liver transplantation was simulated subsequently, and different modus operandi were selected successfully. CONCLUSION: The digitized medical image processing system may be valuable for liver transplantation.

  16. Plasma Surface Treatment of Powder Materials — Process and Application

    Directory of Open Access Journals (Sweden)

    Monika Pavlatová

    2012-01-01

    Full Text Available Polyolefin particles are hydrophobic, and this prevents their use for various applications. Plasma treatment is an environment-friendly polyolefin hydrophilisation method. We developed an industrial-scale plant for plasma treatment of particles as small as micrometers in diameter. Materials such as PE waxes, UHMWPE and powders for rotomolding production were tested to verify their new surface properties. We achieved significantly increased wettability of the particles, so that they are very easily dispersive in water without agglomeration, and their higher surface energy is retained even after sintering in the case of rotomolding powders.

  17. HEAT EXCHANGER EJECTOR APPLICATION IN PRODUCTS REFRIGERATION PROCESSING

    OpenAIRE

    В.О. Когут; В.В. Мінєнков; М.Г. Хмельнюк

    2014-01-01

    This paper describes the use of a heat-exchanger ejector device for air humidification in a refrigeration treatment camera of meat half-carcasses, and the possibility of its application for artificial snow. The system of a two-step meat moistening in the isolated compartment by treating meat with a mixture of cooled air and the fine crystal ice particles is represented in this article. The design scheme and the principle of the heat exchanger ejector is shown. The ice crystals formed at the o...

  18. Pulsed electrical discharges for medicine and biology techniques, processes, applications

    CERN Document Server

    Kolikov, Victor

    2015-01-01

    This book presents the application of pulsed electrical discharges in water and water dispersions of metal nanoparticles in medicine (surgery, dentistry, and oncology), biology, and ecology. The intensive electrical and shock waves represent a novel technique to destroy viruses and this way to  prepare anti-virus vaccines. The method of pulsed electrical discharges in water allows to decontaminate water from almost all known bacteria and spores of fungi being present in human beings. The nanoparticles used are not genotoxic and mutagenic. This book is useful for researchers and graduate students.

  19. Application of Strategic Planning Process with Fleet Level Analysis Methods

    Science.gov (United States)

    Mavris, Dimitri N.; Pfaender, Holger; Jimenez, Hernando; Garcia, Elena; Feron, Eric; Bernardo, Jose

    2016-01-01

    The goal of this work is to quantify and characterize the potential system-wide reduction of fuel consumption and corresponding CO2 emissions, resulting from the introduction of N+2 aircraft technologies and concepts into the fleet. Although NASA goals for this timeframe are referenced against a large twin aisle aircraft we consider their application across all vehicle classes of the commercial aircraft fleet, from regional jets to very large aircraft. In this work the authors describe and discuss the formulation and implementation of the fleet assessment by addressing the main analytical components: forecasting, operations allocation, fleet retirement, fleet replacement, and environmental performance modeling.

  20. CVD growth and processing of graphene for electronic applications

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Shishir; Rezvani, Ehsan; Nolan, Hugo; Duesberg, Georg S. [School of Chemistry, Trinity College Dublin, Dublin 2 (Ireland); Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Trinity College Dublin, Dublin 2 (Ireland); McEvoy, Niall; Kim, Hye-Young; Lee, Kangho; Peltekis, Nikos; Weidlich, Anne; Daly, Ronan [Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Trinity College Dublin, Dublin 2 (Ireland)

    2011-11-15

    The remarkable properties of graphene have potential for numerous applications; however, their exploitation depends on its reliable production. The chemical vapour deposition (CVD) growth of graphene on metal surfaces has become one of the most promising strategies for the production of high quality graphene in a scaleable manner. Here, we discuss graphene growth on nickel (Ni) and copper (Cu) directly from both gaseous hydrocarbons and solid carbon precursors. Further, we discuss in detail the transfer of graphene films to insulating substrates, by direct and polymer supported transfer methods. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)