Regional scale flood modeling using NEXRAD rainfall, GIS, and HEC-HMS/RAS: a case study for the San Antonio River Basin Summer 2002 storm event.

Science.gov (United States)

Knebl, M R; Yang, Z-L; Hutchison, K; Maidment, D R

2005-06-01

This paper develops a framework for regional scale flood modeling that integrates NEXRAD Level III rainfall, GIS, and a hydrological model (HEC-HMS/RAS). The San Antonio River Basin (about 4000 square miles, 10,000 km2) in Central Texas, USA, is the domain of the study because it is a region subject to frequent occurrences of severe flash flooding. A major flood in the summer of 2002 is chosen as a case to examine the modeling framework. The model consists of a rainfall-runoff model (HEC-HMS) that converts precipitation excess to overland flow and channel runoff, as well as a hydraulic model (HEC-RAS) that models unsteady state flow through the river channel network based on the HEC-HMS-derived hydrographs. HEC-HMS is run on a 4 x 4 km grid in the domain, a resolution consistent with the resolution of NEXRAD rainfall taken from the local river authority. Watershed parameters are calibrated manually to produce a good simulation of discharge at 12 subbasins. With the calibrated discharge, HEC-RAS is capable of producing floodplain polygons that are comparable to the satellite imagery. The modeling framework presented in this study incorporates a portion of the recently developed GIS tool named Map to Map that has been created on a local scale and extends it to a regional scale. The results of this research will benefit future modeling efforts by providing a tool for hydrological forecasts of flooding on a regional scale. While designed for the San Antonio River Basin, this regional scale model may be used as a prototype for model applications in other areas of the country.

Moral Reasoning among HEC Members: An Empirical Evaluation of the Relationship of Theory and Practice in Clinical Ethics Consultation.

Science.gov (United States)

Wasserman, Jason Adam; Stevenson, Shannon Lindsey; Claxton, Cassandra; Krug, Ernest F

2015-01-01

In light of the ongoing development and implementation of core competencies in bioethics, it is important to proceed with a clear sense of how bioethics knowledge is utilized in the functioning of hospital ethics committees (HECs). Without such an understanding, we risk building a costly edifice on a foundation that is ambiguous at best. This article examines the empirical relationship between traditional paradigms of bioethics theory and actual decision making by HEC members using survey data from HEC members. The assumption underlying the standardization of qualifications and corresponding call for increased education of HEC members is that they will base imminent case decisions on inculcated knowledge. Our data suggest, however, that HEC members first decide intuitively and then look for justification, thereby highlighting the need to re-examine the pedagogical processes of ethics education in the process of standardizing and improving competencies. Copyright 2015 The Journal of Clinical Ethics. All rights reserved.

Comparative analysis between Hec-RAS models and IBER in the hydraulic assessment of bridges

OpenAIRE

Rincón, Jean; Pérez, María; Delfín, Guillermo; Freitez, Carlos; Martínez, Fabiana

2017-01-01

This work aims to perform a comparative analysis between the Hec-RAS and IBER models, in the hydraulic evaluation of rivers with structures such as bridges. The case of application was the La Guardia creek, located in the road that communicates the cities of Barquisimeto-Quíbor, Venezuela. The first phase of the study consisted in the comparison of the models from the conceptual point of view and the management of both. The second phase focused on the case study, and the comparison of ...

Intestinal Targeting of Ganciclovir Release Employing a Novel HEC-PAA Blended Lyomatrix.

Science.gov (United States)

Mabrouk, Mostafa; Mulla, Jameel A S; Kumar, Pradeep; Chejara, Dharmesh R; Badhe, Ravindra V; Choonara, Yahya E; du Toit, Lisa C; Pillay, Viness

2016-10-01

A hydroxyethylcellulose-poly(acrylic acid) (HEC-PAA) lyomatrix was developed for ganciclovir (GCV) intestine targeting to overcome its undesirable degradation in the stomach. GCV was encapsulated within the HEC-PAA lyomatrix prepared by lyophilization. Conventional tablets were also prepared with identical GCV concentrations in order to compare the GCV release behavior from the lyomatrix and tablets. GCV incorporation (75.12%) was confirmed using FTIR, DSC, and TGA. The effect of GCV loading on the microstructure properties of the lyomatrix was evaluated by SEM, AFM, and BET surface area measurements. The in vitro drug release study showed steady and rapid release profiles from the GCV-loaded lyomatrix compared with the tablet formulation at identical pH values. Minimum GCV release was observed at acidic pH (≤40%) and maximum release occurred at intestinal pH values (≥90%) proving the intestinal targeting ability of the lyomatrix. Kinetic modeling revealed that the GCV-loaded lyomatrix exhibited zero-order release kinetics (n = 1), while the tablets were best described via the Peppas model. Textural analysis highlighted enhanced matrix resilience and rigidity gradient (12.5%, 20 Pa) for the GCV-loaded lyomatrix compared to the pure (7%, 9.5 Pa) HEC-PAA lyomatrix. Bench-top MRI imaging was used to confirm the mechanism of GCV release behavior by monitoring the swelling and erosion rates. The swelling and erosion rate of the tablets was not sufficient to achieve rapid zero-order GCV release as with the lyomatrix. These combined results suggest that the HEC-PAA lyomatrix may be suitable for GCV intestinal targeting after oral administration.

An assessment of travel time for spills management - using HEC-RAS water quality analysis

Energy Technology Data Exchange (ETDEWEB)

Disley, Tom; Gharabaghi, Bahram; Perdikaris, John [University of Guelph, Guelph, (Canada); Singh, Amanjot; Dougherty, Jennifer [Credit Valley Conservation Authority, Mississauga, (Canada)

2010-07-01

In order to mitigate the detrimental effects that contaminants such as petrochemical and chemical spills may have on the environment it is critical to understand their transport. This paper presented an assessment of travel time for spills management using HEC-RAS water quality analysis on the Credit River Watershed. It is a 1000 km2 area of urban and rural landscapes drained by 90 km of the main Credit River. The study focused on the mixing characteristics of 5 stream reaches in the Credit River watershed. Dye tracing was done under three different flow conditions to obtain a longitudinal dispersion coefficient, which is a necessary parameter for predicting and modelling time concentration curves downstream of a spill. The longitudinal dispersion coefficient was input into the US Army Corp of Engineers, Hydrologic Engineering Centers River Analysis System (HEC RAS) to predict time concentration curves. The HEC RAS model produced average travel time close to those measured in the field after final calibration was completed.

An assessment of travel time for spills management - using HEC-RAS water quality analysis

International Nuclear Information System (INIS)

Disley, Tom; Gharabaghi, Bahram; Perdikaris, John; Singh, Amanjot; Dougherty, Jennifer

2010-01-01

In order to mitigate the detrimental effects that contaminants such as petrochemical and chemical spills may have on the environment it is critical to understand their transport. This paper presented an assessment of travel time for spills management using HEC-RAS water quality analysis on the Credit River Watershed. It is a 1000 km2 area of urban and rural landscapes drained by 90 km of the main Credit River. The study focused on the mixing characteristics of 5 stream reaches in the Credit River watershed. Dye tracing was done under three different flow conditions to obtain a longitudinal dispersion coefficient, which is a necessary parameter for predicting and modelling time concentration curves downstream of a spill. The longitudinal dispersion coefficient was input into the US Army Corp of Engineers, Hydrologic Engineering Centers River Analysis System (HEC RAS) to predict time concentration curves. The HEC RAS model produced average travel time close to those measured in the field after final calibration was completed.

Hydrologic modeling of Guinale River Basin using HEC-HMS and synthetic aperture radar

Science.gov (United States)

Bien, Ferdinand E.; Plopenio, Joanaviva C.

2017-09-01

This paper presents the methods and results of hydrologic modeling of Guinale river basin through the use of HEC-HMS software and Synthetic Aperture Radar Digital Elevation Model (SAR DEM). Guinale River Basin is located in the province of Albay, Philippines which is one of the river basins covered by the Ateneo de Naga University (ADNU) Phil-LiDAR 1. This research project was funded by the Department of Science and Technology (DOST) through the Philippine Council for Industry, Energy and Emerging Technology Research and Development (PCIEERD). Its objectives are to simulate the hydrologic model of Guinale River basin using HEC-HMS software and SAR DEM. Its basin covers an area of 165.395 sq.km. and the hydrologic model was calibrated using the storm event typhoon Nona (international name Melor). Its parameter had undergone a series of optimization processes of HEC-HMS software in order to produce an acceptable level of model efficiency. The Nash-Sutcliffe (E), Percent Bias and Standard Deviation Ratio were used to measure the model efficiency, giving values of 0.880, 0.260 and 0.346 respectively which resulted to a "very good" performance rating of the model. The flood inundation model was simulated using Legazpi Rainfall Intensity Duration Frequency Curves (RIDF) and HEC-RAS software developed by the US Army corps of Engineers (USACE). This hydrologic model will provide the Municipal Disaster Risk Reduction Management Office (MDRRMO), Local Government units (LGUs) and the community a tool for the prediction of runoff in the area.

THE USE OF HEC-RAS MODELLING IN FLOOD RISK ANALYSIS

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IOSUB MARINA

2015-03-01

Full Text Available The fact that, in the Ozana drainage basin, most of the people have built their homes in the river valley, determines that a study focused on identifying the areas exposed to hydrological risk is vital, mostly in the development decisions for villages and in the creation of management plans for emergency situations. This study analyses the mapping methodology of the flood prone areas in the middle and lower sector of the Pluton river, which is a tributary of Ozana river, in its upper sector. In order to correctly draw the flood risk maps, the HEC-RAS method has been used, together with the HEC-GeoRAS extension, in ArcGIS. The results that have been obtained, correlate with the field situation in a very high proportion: for a 1% occurance flood, almost 123 households have been damaged, and according to the simulation, a number of 147 buildings have been damaged, therefore other probabilities (that overcome the 1% situation can be used for similar simulations.

Potential Improvements for HEC-HMS Automated Parameter Estimation

Science.gov (United States)

2006-08-01

and is now a graduate student in the Department of Civil and Environmental Engineering at the University of Illinois at Urbana /Champaign. Daniel...divided into 14 nested subwatersheds with a flow measuring flume constructed at each of the subwatershed outlets. The drainage areas above the...boundaries and stream network, and rain and stream gauge locations are shown in Figure 1. The first HEC-HMS model was applied to the 39.8-acre drainage

Hydrological Modelling using HEC-HMS for Flood Risk Assessment of Segamat Town, Malaysia

Science.gov (United States)

Romali, N. S.; Yusop, Z.; Ismail, A. Z.

2018-03-01

This paper presents an assessment of the applicability of using Hydrologic Modelling System developed by the Hydrologic Engineering Center (HEC-HMS) for hydrological modelling of Segamat River. The objective of the model application is to assist in the assessment of flood risk by providing the peak flows of 2011 Segamat flood for the generation of flood mapping of Segamat town. The capability of the model was evaluated by comparing the historical observed data with the simulation results of the selected flood events. The model calibration and validation efficiency was verified using Nash-Sutcliffe model efficiency coefficient. The results demonstrate the interest to implement the hydrological model for assessing flood risk where the simulated peak flow result is in agreement with historical observed data. The model efficiency of the calibrated and validated exercises is 0.90 and 0.76 respectively, which is acceptable.

Evaluation of Control and Adjustment Structures of the Shibab Main Canal Using HEC-RAS

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maryam mohammadi

2017-02-01

Full Text Available Introduction: Poor performance of irrigation and drainage networks causes to reduce the transfer and distribution throughputs and in result comes useless water and makes too much consumption in forming. A significant portion of water losses in irrigation and drainage networksis related to transmission and distribution. Therefor more consideration in thrirrigation network management, improve irrigation efficiency and also the exploitation of water resources, especially in the agricultural sector is necessary. Controlling and adjusting structures of water level in the direction of drainage and irrigation canals can influence on increasing of throughput and decrease the use of water. So, right choosing and recognition of the deficiencies of these structures helps carry up the throughput of the networks and prevents to waste water. It is hard to solve equations of water flow in canals and related institutions by using analytic methods. For this reason, this research was done with HEC-RAS hydraulical model in the main channelof irrigation and drainage network of Sistan plain. Materials and Methods: Sistan plain is located in southeastern of Iran with good potential for agricultural production because of the alluvial sediments from Hirmand River. 23820 ha of the Sistan plain is covered by 5 blocksof the Shibab irrigation and drainage network. While Sistan’sShibab irrigation network efficiency is low, HEC-RAS Hydraulics model in unsteady condition was performed to control and adjust this network’s main canal in approximately 19 Km length. In this research, the evaluation model in the canal was performed for more suitable intakingwater in the quadruple order 2 canals . So, the existing structure’s operation was analyzed on controlling structures in management and lack of management situations.This research was assessed during a 15-day impounding period using hydraulic model of HEC-RAS with the aim of performance and operation evaluation of

Development of a HEC-RAS temperature model for the North Santiam River, northwestern Oregon

Science.gov (United States)

Stonewall, Adam J.; Buccola, Norman L.

2015-01-01

A one-dimensional, unsteady streamflow and temperature model (HEC-RAS) of the North Santiam and Santiam Rivers was developed by the U.S. Geological Survey to be used in conjunction with previously developed two-dimensional hydrodynamic water-quality models (CE-QUAL-W2) of Detroit and Big Cliff Lakes upstream of the study area. In conjunction with the output from the previously developed models, the HEC-RAS model can simulate streamflows and temperatures within acceptable limits (mean error [bias] near zero; typical streamflow errors less than 5 percent; typical water temperature errors less than 1.0 °C) for the length of the North Santiam River downstream of Big Cliff Dam under a series of potential future conditions in which dam structures and/or dam operations are modified to improve temperature conditions for threatened and endangered fish. Although a two-dimensional (longitudinal, vertical) CE-QUAL-W2 model for the North Santiam and Santiam Rivers downstream of Big Cliff Dam exists, that model proved unstable under highly variable flow conditions. The one-dimensional HEC-RAS model documented in this report can better simulate cross-sectional-averaged stream temperatures under a wide range of flow conditions.

ANÁLISIS COMPARATIVO ENTRE LOS MODELOS HEC-RAS E IBER EN LA EVALUACIÓN HIDRÁULICA DE PUENTES

OpenAIRE

Jean Carlos Rincón; María Pérez; Guillermo Delfín; Carlos Freitez; Fabiana Martínez

2017-01-01

This work aims to perform a comparative analysis between the Hec-RAS and IBER models, in the hydraulic evaluation of rivers with structures such as bridges. The case of application was the La Guardia creek, located in the road that communicates the cities of Barquisimeto-Quíbor, Venezuela. The first phase of the study consisted in the comparison of the models from the conceptual point of view and the management of both. The second phase focused on the case study, and the comparison of the res...

Flood Hazard Zonation by Combining Mod-Clark and HEC-RAS Models in Bustan Dam Basin, Golestan Province

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Z. Parisay

2014-12-01

Full Text Available Flood is one of the devastating phenomena which every year incurs casualties and property damages. Flood zonation is an efficient technique for flood management. The main goal of this research is flood hazard and risk zonation along a 21 km reach of the Gorganrud river in Bustan dam watershed considering two conditions: present landuse condition and scenario planning. To this end a combination of a hydrologic model (the distributed HEC-HMS with the Mod-Clark transform option and a hydraulic model (HEC-RAS were used. The required inputs to run the Mod-Clarck module of HEC-HMS are gridded files of river basin, curve number and rainfall with the SHG coordinate system and DSS format. In this research the input files were prepared using the Watershed Modeling System (WMS at cell size of 200 m. Since the Mod-Clark method requires rainfall data as radar format (NEXRAD, the distributed rainfall mapseries with time intervals of 15 minutes prepared within the PCRaster GIS system were converted to the DSS format using the asc2dss package. also the curve number map was converted to the DSS format using HEC-GeoHMS. Then, these DSS files were substituted with rainfall and curve number maps within the WMS. After calibration and validation, model was run for return periods of 2, 5, 10, 25, 50, 100 and 200 years, in two conditions of current landuse and scenario planning. The simulated peak discharge data, geometric parameters of river and cross section (at 316 locations data prepared by the HEC-GeoRAS software and roughness coefficients data, were used by the HEC-RAS software to simulate the hydraulic behavior of the river and flood inundation area maps were produced using GIS. The results of the evaluation showed that in addition to the percent error in peak flow, less than 3.2%, the model has a good performance in peak flow simulation, but is not successful in volume estimation. The results of flood zones revealed that from the total area in floodplain with

A Self-Powered Thin-Film Radiation Detector Using Intrinsic High-Energy Current (HEC) (Author’s Final Version)

Science.gov (United States)

2016-09-08

of electromagnetic 85 pulse effects on cables and electrical devices4 and as a self - powered detector for in-core neutron flux measurement in nuclear...AFCEC-CX-TY-TP-2016-0003 A SELF - POWERED THIN-FILM RADIATION DETECTOR USING INTRINSIC HIGH-ENERGY CURRENT (HEC) (AUTHOR’S FINAL VERSION...14 -- 5 Oct 15 A self - powered thin-film radiation detector using intrinsic high-energy current (HEC) (Author’s Final Version) FA8051-15-P-0010

Osteopontin Promotes Invasion, Migration and Epithelial-Mesenchymal Transition of Human Endometrial Carcinoma Cell HEC-1A Through AKT and ERK1/2 Signaling.

Science.gov (United States)

Li, Yinghua; Xie, Yunpeng; Cui, Dan; Ma, Yanni; Sui, Linlin; Zhu, Chenyang; Kong, Hui; Kong, Ying

2015-01-01

Osteopontin (OPN) is an Extracellular Matrix (ECM) molecule and is involved in many physiologic and pathologic processes, including cell adhesion, angiogenesis and tumor metastasis. OPN is a well-known multifunctional factor involved in various aspects of cancer progression, including endometrial cancer. In this study, we examined the significance of OPN in endometrial cancer. The proliferation, migration and invasion ability of HEC-1A cells were detected by Cell Counting Kit-8 (CCK-8), Wound scratch assay and transwell. Western blots were employed to detect the expression of Matrix metalloproteinase-2 (MMP-2) and epithelial-mesenchymal transition (EMT)-related factors in HEC-1A cells treated with rhOPN. rhOPN promotes cell proliferation, migration and invasion in HEC-1A cells. rhOPN influenced EMT-related factors and MMP-2 expression in HEC-1A cells. rhOPN promoted HEC-1A cells migration, invasion and EMT through protein kinase B (PKB/AKT) and Extracellular regulated protein kinases (ERK1/2) signaling pathway. These results may open up a novel therapeutic strategy for endometrial cancer: namely, rhOPN have important roles in controlling growth of endometrial of cancer cells and suggest a novel target pathway for treatment of this cancer. © 2015 The Author(s) Published by S. Karger AG, Basel.

Osteopontin Promotes Invasion, Migration and Epithelial-Mesenchymal Transition of Human Endometrial Carcinoma Cell HEC-1A Through AKT and ERK1/2 Signaling

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Yinghua Li

2015-10-01

Full Text Available Background/Aims: Osteopontin (OPN is an Extracellular Matrix (ECM molecule and is involved in many physiologic and pathologic processes, including cell adhesion, angiogenesis and tumor metastasis. OPN is a well-known multifunctional factor involved in various aspects of cancer progression, including endometrial cancer. In this study, we examined the significance of OPN in endometrial cancer. Methods: The proliferation, migration and invasion ability of HEC-1A cells were detected by Cell Counting Kit-8 (CCK-8, Wound scratch assay and transwell. Western blots were employed to detect the expression of Matrix metalloproteinase-2 (MMP-2 and epithelial-mesenchymal transition (EMT-related factors in HEC-1A cells treated with rhOPN. Results: rhOPN promotes cell proliferation, migration and invasion in HEC-1A cells. rhOPN influenced EMT-related factors and MMP-2 expression in HEC-1A cells. rhOPN promoted HEC-1A cells migration, invasion and EMT through protein kinase B (PKB/AKT and Extracellular regulated protein kinases (ERK1/2 signaling pathway. Conclusions: These results may open up a novel therapeutic strategy for endometrial cancer: namely, rhOPN have important roles in controlling growth of endometrial of cancer cells and suggest a novel target pathway for treatment of this cancer.

The Anticancer Effects of Radachlorin-mediated Photodynamic Therapy in the Human Endometrial Adenocarcinoma Cell Line HEC-1-A.

Science.gov (United States)

Kim, Su-Mi; Rhee, Yun-Hee; Kim, Jong-Soo

2017-11-01

We investigated the effect of photodynamic therapy (PDT) using radachlorin on invasion, vascular formation and apoptosis by targeting epidermal growth factor receptor (EGFR)/vascular endothelial growth factor receptor 2 (VEGFR2) signaling pathways in the HEC-1-A endometrial adenocarcinoma cell line. To investigate the apoptotic pathway, we performed the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay, and western blot analysis. We also evaluated the effects of PDT on tubular capillary formation in and invasion by HEC-1-A cells with a tube formation assay, invasion assay, prostaglandin E2 (PGE2) assay, and western blot analysis. PDT had anticancer effects on HEC-1-A through activation of the intrinsic pathway of apoptosis via caspase-9 and poly-(ADP-ribose) polymerase (PARP). PDT also inhibited tubular capillary formation in and invasion by HEC-1-A under VEGF pretreatment, that resulted from down-regulation of VEGFR2, EGFR, Ras homolog gene family/ member A (RhoA) and PGE2. These results are indicative of the specificity of radachlorin-mediated PDT to VEGF. The major advantage of radachlorin-mediated PDT is its selectivity for cancer tissue while maintaining adjacent normal endometrial tissue. Therefore, radachlorin-mediated PDT might offer high anticancer efficacy for endometrial adenocarcinoma and an especially useful modality for preserving fertility. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Stable and pH-responsive core-shell nanoparticles based on HEC and PMAA networks via template copolymerization

Science.gov (United States)

Zhang, Y.; Jin, Q.; Chen, Y.; Zhao, J.

2011-10-01

Taking advantage of the specific hydrogen bonding interactions, stable and pH-responsive core-shell nanoparticles based on hydroxyethyl cellulose (HEC) and polymethacrylic acid (PMAA) networks, with a size ranging from 190 to 250 nm, can be efficiently prepared via facile one-step co-polymerization of methacrylic acid (MAA) and N, N'-methylenebisacrylamide (MBA) on HEC template in water. Using dynamic light scattering, electrophoretic light scattering, fluorescence spectrometry, thermo-gravimetric analysis, TEM, and AFM observations, the influence of crosslinker MBA as well as the reaction parameters were studied. The results show that after the introduction of crosslinker MBA, the nanoparticles became less compact; their size exhibited a smaller pH sensitivity, and their stability against pH value was improved greatly. Furthermore, the size, structure, and pH response of the nanoparticles can be adjusted via varying the reaction parameters: nanoparticles of smaller size, more compact structure, and higher swelling capacity were produced as pH value of the reaction medium increased or the HEC/MAA ratio decreased; while nanoparticles of smaller size, less compact structure and smaller swelling capacity were produced as the total feeding concentration increased.

[Regulation of [12Asp]K-ras4B on transcriptional activity of estrogen receptor in endometrial carcinoma HEC-1A cell lines].

Science.gov (United States)

Gui, Li-ming; Wei, Li-hui; Xu, Ming-xu; Wang, Jian-liu; Zhong, Ying-cheng; Li, Xiao-ping; Tu, Zheng; Sun, Peng-ming; Ma, Da-long

2004-01-01

To investigate the effect of mutant-type [(12)Asp]K-ras4B gene on the expression of estrogen receptor (ER) alpha and beta and their transcriptional activity as a transcription factor in endometrial carcinoma HEC-1A cell line. (1) Effect of [(12)Asp]K-ras4B on the expression of ER alpha and beta were determined using Western blot assay. (2) Eukaryotic expression plasmid pGL3-luciferase-ERE containing luciferase report gene and estrogen receptor element (ERE) was constructed, and co-transfected into NIH3T3 and HEC-1A cell lines with pEGFP-N1 to examine the effect of [(12)Asp]K-ras4B on ER transcription that is regulated by estradiol. In addition, they were transfected into pSV5-HER0 (containing full length wide type ERalpha cDNA) and pCMV-rafS621A (inhibiting raf kinase) plasmids to test the effect of [(12)Asp]K-ras4B/raf signal pathway on transcriptional activity of ER proteins. (1) Protein level of ERs expressed in pcDI transfected control cells was low while it was increased for 3.6-fold (97 +/- 25, 349 +/- 67, P ras4B NIH3T3 cells after transfection. (2) In pcDI-[(12)Asp]K-ras4B NIH3T3 cells, the ratios for ERalpha and and ERbeta levels before transfection of rafS621A plasmids to that after the transfection, were 2.4:1 (724 +/- 45, 310 +/- 46, P HEC-1A cells, these ratios were 2.1:1 (566 +/- 22, 279 +/- 30, P ras4B NIH3T3 cells, 19-fold (141 +/- 39, 2644 +/- 331, P HEC-1A cells, respectively, when compared with those in the absence of E(2). (4) In pSV5-HER0 transfected pcDI-[(12)Asp] K-ras4B NIH3T3 cells and HEC-1A cells, compared to the untransfected cells, the ER transcriptional activity in the transfected cells increased markedly. The luciferase activity was increased for 8-fold (1048 +/- 91, 8099 +/- 452, P HEC-1A cells and pcDI-[(12)Asp]K-ras4B NIH3T3 cells. The ratio of luciferase activities in pcDI-[(12)Asp]K-ras4B NIH3T3 and HEC-1A cells, before and after transfection was 7.8:1 (1184 +/- 168, 152 +/- 27, P ras4B can enhance the expression of ERalpha and

Calibration and Validation Parameter of Hydrologic Model HEC-HMS using Particle Swarm Optimization Algorithms – Single Objective

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R. Garmeh

2016-02-01

Full Text Available Introduction: Planning and management of water resource and river basins needs use of conceptual hydrologic models which play a significant role in predicting basins response to different climatic and meteorological processes. Evaluating watershed response through mathematical hydrologic models requires finding a set of parameter values of the model which provides thebest fit between observed and estimated hydrographs in a procedure called calibration. Asmanual calibration is tedious, time consuming and requires personal experience, automaticcalibration methods make application of more significant CRR models which are based onusing a systematic search procedure to find good parameter sets in terms of at least oneobjective function. Materials and Methods: Conceptual hydrologic models play a significant role inpredicting a basin’s response to different climatic and meteorological processes within natural systems. However, these models require a number of estimated parameters. Model calibration is the procedure of adjusting the parametervalues until the model predictions match the observed data. Manual calibration of high-fidelity hydrologic (simulation models is tedious, time consuming and sometimesimpractical, especially when the number of parameters islarge. Moreover, the high degrees of nonlinearity involved in different hydrologic processes and non-uniqueness ofinverse-type calibration problems make it difficult to find asingle set of parameter values. In this research, the conceptual HEC-HMS model is integrated with the Particle Swarm Optimization (PSO algorithm.The HEC-HMS model was developed as areplacement for HEC-1, which has long been considered as astandard model for hydrologic simulation. Most of thehydrologic models employed in HEC-HMS are event-basedmodels simulating a single storm requiring the specificationof all conditions at the beginning of the simulation. The soil moistureaccounting model in the HEC-HMS is the onlycontinuous

Discovery of 4-aryl-N-arylcarbonyl-2-aminothiazoles as Hec1/Nek2 inhibitors. Part I: optimization of in vitro potencies and pharmacokinetic properties.

Science.gov (United States)

Lee, Ying-Shuan E; Chuang, Shih-Hsien; Huang, Lynn Y L; Lai, Chun-Liang; Lin, Yu-Hsiang; Yang, Ju-Ying; Liu, Chia-Wei; Yang, Sheng-chuan; Lin, Her-Sheng; Chang, Chia-chi; Lai, Jun-Yu; Jian, Pei-Shiou; Lam, King; Chang, Jia-Ming; Lau, Johnson Y N; Huang, Jiann-Jyh

2014-05-22

A series of 4-aryl-N-arylcarbonyl-2-aminothiazoles of scaffold 4 was designed and synthesized as Hec1/Nek2 inhibitors. Structural optimization of 4 led to compound 32 bearing C-4' 4-methoxyphenoxy and 4-(o-fluoropyridyl)carbonyl groups that showed low nanomolar in vitro antiproliferative activity (IC50: 16.3-42.7 nM), high intravenous AUC (64.9 μM·h, 2.0 mg/kg) in SD rats, and significant in vivo antitumor activity (T/C = 32%, 20 mg/kg, IV) in mice bearing human MDA-MB-231 xenografts. Cell responses resulting from Hec1/Nek2 inhibition were observed in cells treated with 32, including a reduced level of Hec1 coimmunoprecipitated with Nek2, degradation of Nek2, mitotic abnormalities, and apoptosis. Compound 32 showed selectivity toward cancer cells over normal phenotype cells and was inactive in a [(3)H]astemizole competitive binding assay for hERG liability screening. Therefore, 32 is as a good lead toward the discovery of a preclinical candidate targeting Hec1/Nek2 interaction.

Calibration of HEC-Ras hydrodynamic model using gauged discharge data and flood inundation maps

Science.gov (United States)

Tong, Rui; Komma, Jürgen

2017-04-01

The estimation of flood is essential for disaster alleviation. Hydrodynamic models are implemented to predict the occurrence and variance of flood in different scales. In practice, the calibration of hydrodynamic models aims to search the best possible parameters for the representation the natural flow resistance. Recent years have seen the calibration of hydrodynamic models being more actual and faster following the advance of earth observation products and computer based optimization techniques. In this study, the Hydrologic Engineering River Analysis System (HEC-Ras) model was set up with high-resolution digital elevation model from Laser scanner for the river Inn in Tyrol, Austria. 10 largest flood events from 19 hourly discharge gauges and flood inundation maps were selected to calibrate the HEC-Ras model. Manning roughness values and lateral inflow factors as parameters were automatically optimized with the Shuffled complex with Principal component analysis (SP-UCI) algorithm developed from the Shuffled Complex Evolution (SCE-UA). Different objective functions (Nash-Sutcliffe model efficiency coefficient, the timing of peak, peak value and Root-mean-square deviation) were used in single or multiple way. It was found that the lateral inflow factor was the most sensitive parameter. SP-UCI algorithm could avoid the local optimal and achieve efficient and effective parameters in the calibration of HEC-Ras model using flood extension images. As results showed, calibration by means of gauged discharge data and flood inundation maps, together with objective function of Nash-Sutcliffe model efficiency coefficient, was very robust to obtain more reliable flood simulation, and also to catch up with the peak value and the timing of peak.

An innovative modeling approach using Qual2K and HEC-RAS integration to assess the impact of tidal effect on River Water quality simulation.

Science.gov (United States)

Fan, Chihhao; Ko, Chun-Han; Wang, Wei-Shen

2009-04-01

Water quality modeling has been shown to be a useful tool in strategic water quality management. The present study combines the Qual2K model with the HEC-RAS model to assess the water quality of a tidal river in northern Taiwan. The contaminant loadings of biochemical oxygen demand (BOD), ammonia nitrogen (NH(3)-N), total phosphorus (TP), and sediment oxygen demand (SOD) are utilized in the Qual2K simulation. The HEC-RAS model is used to: (i) estimate the hydraulic constants for atmospheric re-aeration constant calculation; and (ii) calculate the water level profile variation to account for concentration changes as a result of tidal effect. The results show that HEC-RAS-assisted Qual2K simulations taking tidal effect into consideration produce water quality indices that, in general, agree with the monitoring data of the river. Comparisons of simulations with different combinations of contaminant loadings demonstrate that BOD is the most import contaminant. Streeter-Phelps simulation (in combination with HEC-RAS) is also performed for comparison, and the results show excellent agreement with the observed data. This paper is the first report of the innovative use of a combination of the HEC-RAS model and the Qual2K model (or Streeter-Phelps equation) to simulate water quality in a tidal river. The combination is shown to provide an alternative for water quality simulation of a tidal river when available dynamic-monitoring data are insufficient to assess the tidal effect of the river.

Estimating design flood and HEC-RAS modelling approach for flood analysis in Bojonegoro city

Science.gov (United States)

Prastica, R. M. S.; Maitri, C.; Hermawan, A.; Nugroho, P. C.; Sutjiningsih, D.; Anggraheni, E.

2018-03-01

Bojonegoro faces flood every year with less advanced prevention development. Bojonegoro city development could not peak because the flood results material losses. It affects every sectors in Bojonegoro: education, politics, economy, social, and infrastructure development. This research aims to analyse and to ensure that river capacity has high probability to be the main factor of flood in Bojonegoro. Flood discharge analysis uses Nakayasu synthetic unit hydrograph for period of 5 years, 10 years, 25 years, 50 years, and 100 years. They would be compared to the water maximum capacity that could be loaded by downstream part of Bengawan Solo River in Bojonegoro. According to analysis result, Bengawan Solo River in Bojonegoro could not able to load flood discharges. Another method used is HEC-RAS analysis. The conclusion that shown by HEC-RAS analysis has the same view. It could be observed that flood water loading is more than full bank capacity elevation in the river. To conclude, the main factor that should be noticed by government to solve flood problem is river capacity.

ANÁLISIS COMPARATIVO ENTRE LOS MODELOS HEC-RAS E IBER EN LA EVALUACIÓN HIDRÁULICA DE PUENTES

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Jean Carlos Rincón

2017-06-01

Full Text Available This work aims to perform a comparative analysis between the Hec-RAS and IBER models, in the hydraulic evaluation of rivers with structures such as bridges. The case of application was the La Guardia creek, located in the road that communicates the cities of Barquisimeto-Quíbor, Venezuela. The first phase of the study consisted in the comparison of the models from the conceptual point of view and the management of both. The second phase focused on the case study, and the comparison of the results obtained from the hydraulic analysis. It was observed that the behavior in both models presented great similarity in the flow profile as in the regime. Upstream of the two bridges predominate the subcritical regime, where the highest depths and the lowest velocities are present. The opposite occurs downstream of the two bridges, where the supercritical regime prevails, high speeds and minimum depths. It is concluded that, for rivers with simple geometry and preferably with a single bridge, the Hec-RAS one-dimensional software is presented as the best alternative of use due to the ease of data entry, providing reliable results in a shorter time. While the IBER package is two-dimensional, it represents a better option for modeling rivers with more irregular geometries, when there is a special interest in the hydraulic behavior of the flow through stirrups and stacks, and having two or more bridges with separation reduced.

Studi Kapasitas Sungai Riam Kiwa Menggunakan Hec-ras 4.1.0

OpenAIRE

Noor, M. Azhari; Utomo, Budi

2013-01-01

South Kalimantan is not spared by the flood. One of the rivers that floods are the river Riam Kiwa. The area being flooded each year is the District Astambul. This research will discuss about the capacity of the river Riam Kiwa Astambul Ruas assisted by HEC-RAS software 4.1.0.The method used is a field research conducted along the river Riam Kiwa Astambul segment, so we get the river Riam Kiwa geometry data were reviewed. The data is then combined with hydrological data so it can do the analy...

Estimation Curve Numbers using GIS and Hec-GeoHMS Model

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Hayat Kareem Shukur

2017-05-01

Full Text Available Recently, the development and application of the hydrological models based on Geographical Information System (GIS has increased around the world. One of the most important applications of GIS is mapping the Curve Number (CN of a catchment. In this research, three softwares, such as an ArcView GIS 9.3 with ArcInfo, Arc Hydro Tool and Geospatial Hydrologic Modeling Extension (Hec-GeoHMS model for ArcView GIS 9.3, were used to calculate CN of (19210 ha Salt Creek watershed (SC which is located in Osage County, Oklahoma, USA. Multi layers were combined and examined using the Environmental Systems Research Institute (ESRI ArcMap 2009. These layers are soil layer (Soil Survey Geographic SSURGO, 30 m x 30 m resolution of Digital Elevation Model (DEM, land use layer (LU, “Look–Up tables” and other layers resulted from running the software. Curve Number which expresses a catchment’s response to a storm event has been estimated in this study to each land parcel based on LU layer and soil layer within each parcel. The results showed that a CN of 100 (dark Blue means surface water. The high curve numbers (100 -81 (Blue and light Blue corresponding to urbanized areas means high runoff and low infiltration; whereas low curve numbers (77- 58 (Brown and light Brown corresponding to the forested area means low runoff and high infiltration. Four classes of land cover have been identified; these are surface water, medium residential, forest and agriculture.

Using HEC-RAS to Enhance Interpretive Capabilities of Geomorphic Assessments

Science.gov (United States)

Keefer, L. L.

2005-12-01

The purpose of a geomorphic assessment is to characterize and evaluate a fluvial system for determining the past watershed and channel conditions, current geomorphic character and potential future channel adjustments. The geomorphic assessment approach utilized by the Illinois State Water Survey assesses channel response to disturbance at multiple temporal and spatial scales to help identify the underlying factors and events which led to the existing channel morphology. This is accomplished through two phases of investigation that involve a historical and physical analysis of the watershed, disturbance history, and field work at increasing levels of detail. To infer future channel adjustments, the geomorphic assessment protocol combines two methods of analyses that are dependent on the quantity and detail of the available data. The first method is the compilation of multiple lines of evidence using qualitative information related to the dominant fluvial environment, channel gradient, stream power thresholds, and channel evolution models. The second method is the use of hydraulic models which provide additional interpretative skills to evaluate potential channel adjustments. The structured data collection framework of the geomorphic assessment approach is used for the development of a HEC-RAS model. The model results are then used as another tool to determine the influence of bridges and control structures on channel stability, stream power profiles to identify potential channel bed degradation zones, and provide data for physically-based bank stability models. This poster will demonstrate the advantages of using a hydraulic model, such as HEC-RAS, to expand the interpretive capabilities of geomorphic assessments. The results from applying this approach will be demonstrated for the Big Creek watershed of the Cache River Basin in southern Illinois.

Alternatif Pengendalian Banjir Kali Juana Berbasis Model HEC-RAS

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Teguh Marhendi

2017-02-01

Full Text Available Kejadian banjir di Kali Juana terjadi setiap musim hujan berlangsung. Beberapa kecamatan seperti Kecamatan Kaliwungu, Undaan dan Mejobo (Kab. Kudus serta Pati, Margorejo dan Juwana (Kab. Pati selalu menjadi daerah genangan banjir. Beberapa upaya pengendalian banjir sudah dilakukan seperti upaya normalisasi dan perbaikan tanggul. Namun mengingat kompleksnya sistem aliran banir di Kali Juana, upaya tesebut belum memberikan hasil yang memadai. Kajian ini dimaksudkan untuk menganalisis alternatif pengendalian banjir di Kali Juana menggunakan analisis model HEC-RAS. Analisis dilakukan dengan melakukan simulasi terhadap beberapa bentuk upaya pengendalian, guna mengurangi besaran banjir. Hasil analisis menunjukkan bahwa terdapat 6 model alternatif yang muncul dalam pengendalian banjir Kali Juana. Dari beberapa model tersebut, terpilih model simulasi yang meliputi Normalisasi, Tanggul, Waduk logung, 8 kolam Retensi dan Floodway.

Spatiotemporal floodplain mapping and prediction using HEC-RAS - GIS tools: Case of the Mejerda river, Tunisia

Science.gov (United States)

Ben Khalfallah, C.; Saidi, S.

2018-06-01

The floods have become a scourge in recent years (Floods of, 2003, 2006, 2009, 2011, and 2012), increasingly frequent and devastating. Tunisia does not escape flooding problems, the flood management requires basically a better knowledge of the phenomenon (flood), and the use of predictive methods. In order to limit this risk, we became interested in hydrodynamics modeling of Medjerda basin. To reach this aim, rainfall distribution is studied and mapped using GIS tools. In addition, flood and return period estimation of rainfall are calculated using Hyfran. Also, Simulations of recent floods are calculated and mapped using HEC-RAS and HEC-GeoRAS for the most recent flood occurred in February-March 2015 in Medjerda basin. The analysis of the results shows a good correlation between simulated parameters and those measured. There is a flood of the river exceeding 240 m3/s (DGRE, 2015) and more flowing sections are observed in the future simulations; for return periods of 10yr, 20yr and 50yr.

Prototypes of Self-Powered Radiation Detectors Employing Intrinsic High-Energy Current (HEC) (POSTPRINT)

Science.gov (United States)

2016-01-01

neutron sensi- tivities of a Pt self - powered detector ,” IEEE Trans. Nucl. Sci. 25, 292–295 (1978). 6T. A. Dellin, R. E. Huddleston, and C. J...Gamma-sensitive self - powered detectors and their use for in-core flux -mapping,” IEEE Trans. Nucl. Sci. 28, 752–757 (1981). 9E. A. Burke and J. Wall...AFCEC-CX-TY-TP-2016-0006 PROTOTYPES OF SELF - POWERED RADIATION DETECTORS EMPLOYING INTRINSIC HIGH-ENERGY CURRENT (HEC) (POSTPRINT) Piotr

Combined Hydrologic (AGWA-KINEROS2) and Hydraulic (HEC2) Modeling for Post-Fire Runoff and Inundation Risk Assessment through a Set of Python Tools

Science.gov (United States)

Barlow, J. E.; Goodrich, D. C.; Guertin, D. P.; Burns, I. S.

2016-12-01

Wildfires in the Western United States can alter landscapes by removing vegetation and changing soil properties. These altered landscapes produce more runoff than pre-fire landscapes which can lead to post-fire flooding that can damage infrastructure and impair natural resources. Resources, structures, historical artifacts and others that could be impacted by increased runoff are considered values at risk. .The Automated Geospatial Watershed Assessment tool (AGWA) allows users to quickly set up and execute the Kinematic Runoff and Erosion model (KINEROS2 or K2) in the ESRI ArcMap environment. The AGWA-K2 workflow leverages the visualization capabilities of GIS to facilitate evaluation of rapid watershed assessments for post-fire planning efforts. High relative change in peak discharge, as simulated by K2, provides a visual and numeric indicator to investigate those channels in the watershed that should be evaluated for more detailed analysis, especially if values at risk are within or near that channel. Modeling inundation extent along a channel would provide more specific guidance about risk along a channel. HEC-2 and HEC-RAS can be used for hydraulic modeling efforts at the reach and river system scale. These models have been used to address flood boundaries and, accordingly, flood risk. However, data collection and organization for hydraulic models can be time consuming and therefore a combined hydrologic-hydraulic modeling approach is not often employed for rapid assessments. A simplified approach could streamline this process and provide managers with a simple workflow and tool to perform a quick risk assessment for a single reach. By focusing on a single reach highlighted by large relative change in peak discharge, data collection efforts can be minimized and the hydraulic computations can be performed to supplement risk analysis. The incorporation of hydraulic analysis through a suite of Python tools (as outlined by HEC-2) with AGWA-K2 will allow more rapid

Coupling of HEC-HMS and HEC-ResSim in Modeling the Fluctuation of Water Level in Devils Lake Using Heterogeneous Data

Science.gov (United States)

Munna, H. S.; Lim, Y. H.

2010-12-01

Devils Lake, located in Ramsey and Benson County in North Dakota is a sub-basin of the Red River of the North. Although it lies entirely within the Red River Basin, it has no natural outlet at current water levels. Since its inception during the glacier period, Devils Lake has been either rising or falling over the last 10,000 years. Geologic evidence shows that the water level in Devils Lake has fluctuated widely from completely dry (about 1400 feet AMSL) to overflowing into the Sheyenne River (about 1459 feet AMSL). The uncontrolled growth of the lake has been an alarming issue for North Dakota for the past few years as it causes continuous flooding in the surrounding areas. A hydro-climatic model that can provide simulations of the water level of this lake for a 20 or 50 year time frame can be a useful decision making tool. In a mission to achieve that, heterogeneous data obtained from various sources were used to model the lake. Runoff from precipitation is one of the major inputs to the lake and to model that, eight major watersheds that feed directly to the lake were identified using Digital Elevation Models (DEMs) of thirty meter resolution in ArcGIS environment. Hydrology and Arc Hydro tools were used to delineate the watersheds and sub-basins to generate the runoff using the HEC HMS model. The precipitation time series data collected from both NASA and ground stations were used separately to calibrate the runoff model. The generation of time series runoff values for individual basins for four consecutive years (2001-2004) was applied into HEC-ResSim, a reservoir simulation model, to estimate the lake level series considering the elevation-area-storage relationship and evaporation series from previous USGS studies. It is eminent that seepage under the lake played a key role in calibrating the model with observed elevations. The value of seepage flow was varied over increasing elevations as it depends on the height of water column. The model showed an

Flood Zoning Simulation by HEC-RAS Model (Case Study: Johor River-Kota Tinggi Region)

OpenAIRE

ShahiriParsa, Ahmad; Heydari, Mohammad; Sadeghian, Mohammad Sadegh; Moharrampour, Mahdi

2015-01-01

Flooding of rivers has caused many human and financial losses. Hence, studies and research on the nature of the river is inevitable.However, the behavior of rivers hasmany complexities and in this respect, computer models are efficient tools in order to study and simulate the behavior of rivers with the least possible cost. In this paper, one-dimensional model HEC-RAS was used to simulate the flood zoning in the Kota Tinggi district in Johor state. Implementation processes of the zoning on ca...

Citizen Science Opportunity With the NASA Heliophysics Education Consortium (HEC)-Radio JOVE Project

Science.gov (United States)

Fung, S. F.; Higgins, C.; Thieman, J.; Garcia, L. N.; Young, C. A.

2016-12-01

The Radio JOVE project has long been a hands-on inquiry-based educational project that allows students, teachers and the general public to learn and practice radio astronomy by building their own radio antenna and receiver system from an inexpensive kit that operates at 20.1 MHz and/or using remote radio telescopes through the Internet. Radio JOVE participants observe and analyze natural radio emissions from Jupiter and the Sun. Within the last few years, several Radio JOVE amateurs have upgraded their equipment to make semi-professional spectrographic observations in the frequency band of 15-30 MHz. Due to the widely distributed Radio JOVE observing stations across the US, the Radio JOVE observations can uniquely augment observations by professional telescopes, such as the Long Wavelength Array (LWA) . The Radio JOVE project has recently partnered with the NASA Heliophysics Education Consortium (HEC) to work with students and interested amateur radio astronomers to establish additional spectrograph and single-frequency Radio JOVE stations. These additional Radio JOVE stations will help build a larger amateur radio science network and increase the spatial coverage of long-wavelength radio observations across the US. Our presentation will describe the Radio JOVE project within the context of the HEC. We will discuss the potential for citizen scientists to make and use Radio JOVE observations to study solar radio bursts (particularly during the upcoming solar eclipse in August 2017) and Jovian radio emissions. Radio JOVE observations will also be used to study ionospheric radio scintillation, promoting appreciation and understanding of this important space weather effect.

Flood analysis using HEC-RAS model: a case study for Hafr Al-Batin, Saudi Arabia

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Al-Zahrani Muhammad

2016-01-01

Full Text Available Hafr Al-Batin is a Saudi Arabian city located in the northeastern part of the kingdom. The city lies in the dry valley of Wadi Al-Batin, part of Wadi Al-Rummah, which leads inland towards Medina and formerly emptied into the Arabian Gulf. Hafr Al-Batin is located in an area where three valleys meet, which makes the city under high risk of flooding, especially when intense rain occurs during short duration as in the case of arid and semi-arid regions. The yearly average rainfall intensity of Hafr Al-Baten is estimated to be 125 mm. Recently, extreme rainfall events occurred, generating flood water to flow from all valleys towards the city, causing serious damage to public and private properties. In this study, HEC-HMS and HEC-RAS models are used to simulate flood occurrence in the city. The results indicate that the average flow depths within the part of the main channel passing through Hafr Al-Batin city were 3.02 m, 3.26 m, 3.45 m, 3.76 m, 4.04 m and 4.34 m for the simulated 2, 5, 10, 25, 50 and 100-year design floods, respectively. Flood hazard maps are also generated to identify the areas within the city with high risk of flooding.

THE POSSIBILITIES OF USING HEC-RAS SOFTWARE FOR MODELLING HYDRAULIC CONDITIONS OF WATER FLOW IN THE FISH PASS EXAMPLED BY THE POMIŁOWO BARRAGE ON THE WIEPRZA RIVER

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Mateusz Hammerling

2016-04-01

Full Text Available The aim of the article is to analyse hydraulic conditions of water flow in a fish pass. The test facility is part of the Pomiłowo barrage in the commune of Sławno, Poland. The authors applied HEC-RAS software for modelling hydraulic parameters of the water flow in the fish pass. The data from field measurements was implemented in the software and calculations of changes in the water table in the fish pass were made. The results confirmed the usefulness of HEC-RAS software for estimating hydraulic parameters of water flow in a fish pass. HEC-RAS software enables to take into account the parameters responsible for the phenomena accompanying the flow through a fish pass. Selecting mathematical model parameters (coefficients should be preceded by a multidimensional analysis of the facility. More precise information on hydraulics, hydrology and biology of the test fish pass are also required.

Sub-hectare crop area mapped wall-to-wall in Tigray Ethiopia with HEC processing of WorldView sub-meter panchromatic image texture

Science.gov (United States)

Neigh, C. S. R.; Carroll, M.; Wooten, M.; McCarty, J. L.; Powell, B.; Husak, G. J.; Enenkel, M.; Hain, C.

2017-12-01

Global food production in the developing world occurs within sub-hectare fields that are difficult to identify with moderate resolution satellite imagery. Knowledge about the distribution of these fields is critical in food security programs. We developed a semi-automated image segmentation approach using wall-to-wall sub-meter imagery with high-end computing (HEC) to map crop area (CA) throughout Tigray, Ethiopia that encompasses over 41,000 km2. Our approach tested multiple HEC processing streams to reduce processing time and minimize mapping error. We applied multiple resolution smoothing kernels to capture differences in land surface texture associated to CA. Typically, very-small fields (mean big-data methodology to extract wall-to-wall CA for other regions of the world that have very-small agriculture fields with similar image texture.

A facile synthesis method of hydroxyethyl cellulose-silver nanoparticle scaffolds for skin tissue engineering applications.

Science.gov (United States)

Zulkifli, Farah Hanani; Hussain, Fathima Shahitha Jahir; Zeyohannes, Senait Sileshi; Rasad, Mohammad Syaiful Bahari Abdull; Yusuff, Mashitah M

2017-10-01

Green porous and ecofriendly scaffolds have been considered as one of the potent candidates for tissue engineering substitutes. The objective of this study is to investigate the biocompatibility of hydroxyethyl cellulose (HEC)/silver nanoparticles (AgNPs), prepared by the green synthesis method as a potential host material for skin tissue applications. The substrates which contained varied concentrations of AgNO 3 (0.4%-1.6%) were formed in the presence of HEC, were dissolved in a single step in water. The presence of AgNPs was confirmed visually by the change of color from colorless to dark brown, and was fabricated via freeze-drying technique. The outcomes exhibited significant porosity of >80%, moderate degradation rate, and tremendous value of water absorption up to 1163% in all samples. These scaffolds of HEC/AgNPs were further characterized by SEM, UV-Vis, ATR-FTIR, TGA, and DSC. All scaffolds possessed open interconnected pore size in the range of 50-150μm. The characteristic peaks of Ag in the UV-Vis spectra (417-421nm) revealed the formation of AgNPs in the blend composite. ATR-FTIR curve showed new existing peak, which implies the oxidation of HEC in the cellulose derivatives. The DSC thermogram showed augmentation in T g with increased AgNO 3 concentration. Preliminary studies of cytotoxicity were carried out in vitro by implementation of the hFB cells on the scaffolds. The results substantiated low toxicity of HEC/AgNPs scaffolds, thus exhibiting an ideal characteristic in skin tissue engineering applications. Copyright © 2017 Elsevier B.V. All rights reserved.

GIS inundation mapping and dam breach analysis of Woolwich Dam using HEC-geoRAS

Energy Technology Data Exchange (ETDEWEB)

Mocan, N. [Crozier and Associates Inc., Collingwood, ON (Canada); Joy, D.M. [Guelph Univ., ON (Canada); Rungis, G. [Grand River Conservation Authority, Cambridge, ON (Canada)

2006-07-01

A study was conducted to determine the extent of flood inundation given a hypothetical dam breach scenario of the Woolwich Dam located in the Grand River Watershed, 2.5 km north of the Town of Elmira, Ontario. The dam is operated by the Grand River Conservation Authority and was constructed to provide low-flow augmentation to Canagagigue Creek. Advances in the computational capabilities of numerical models along with the availability of fine resolution geospatial data has lead to significant advances in the evaluation of catastrophic consequences due to the ensuing flood waters when dams fail. The hydraulic models HEC-RAS and HEC-GeoRAS were used in this study along with GIS to produce high resolution spatial and temporal flood inundation mapping. Given the proximity to the Town of Elmira, the dam is classified as having a high hazard potential. The large size and high hazard potential of the dam suggests that the Inflow Design Flood (IDF) is the Probable Maximum Flood (PMF) event. The outlet structure of the spillway consists of 4 ogee-type concrete spillways equipped with radial gates. A low-level concrete pipe located within the spillway structure provides spillage for maintenance purposes. The full flow capacity of the spillway structure is 297 cubic metres per second at the full supply level of 364.8 metres. In addition to GIS flood inundation maps, this paper included the results of flood hydrographs, water surface profiles and peak flow data. It was concluded that techniques used in this analysis should be considered for use in the development of emergency management planning and dam safety assessments across Canada. 6 refs., 3 tabs., 4 figs.

Application of HEC-RAS for flood forecasting in perched river-A case study of hilly region, China

Science.gov (United States)

Sun, Pingping; Wang, Shuqian; Gan, Hong; Liu, Bin; Jia, Ling

2017-04-01

Flooding in small and medium rivers are seriously threatening the safety of human beings’ life and property. The simulation forecasting of the river flood and bank risk in hilly region has gradually become a hotspot. At present, there are few studies on the simulation of hilly perched river, especially in the case of lacking section flow data. And the method of how to determine the position of the levee breach along the river bank is not much enough. Based on the characteristics of the sections in hilly perched river, an attempt is applied in this paper which establishes the correlation between the flow profile computed by HEC-RAS model and the river bank. A hilly perched river in Lingshi County, Shanxi Province of China, is taken as the study object, the levee breach positions along the bank are simulated under four different design storm. The results show that the flood control standard of upper reach is high, which can withstand the design storm of 100 years. The current standard of lower reach is low, which is the flooding channel with high frequency. As the standard of current channel between the 2rd and the 11th section is low, levee along that channel of the river bank is considered to be heighten and reinforced. The study results can provide some technical support for flood proofing in hilly region and some reference for the reinforcement of river bank.

Development of Inundation Map for Hypothetical Asa Dam Break using HEC-RAS and ARC GIS

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O. S. Balogun

2017-12-01

Full Text Available Asa Dam in Ilorin, Nigeria was constructed in the1980s. The dam made of earth material has a length of 507 meters and height of 27 meters. The maximum capacity of the impoundment during the raining season is approximately 43 x 106 m3. Years after construction, tremendous physical development is taking place along the river channel starting from the dam axis towards downstream for a distance of approximately 12 km. It is estimated that several thousands of people are currently living and performing various activities within the vicinity of the river channel. It is therefore necessary to evaluate the risk involved in case of a possible dam break disaster. In view of this, a hypothetical dam break scenario was studied and analyzed using Hydrologic Engineering Center’s River Analysis System computer model. Unsteady flow simulation was performed using geometric data obtained from Digital Terrain Model with 100-year, 24 hr flow event. The HEC-RAS was used in concert with HEC-GeoRAS to assess the flood hazard along the approximately 12 km river channel. The simulated water surface elevations were exported to Arc GIS to produce an inundation map that graphically indicates the extent of the flood hazard. The results show that some important locations such as industrial, residential, motor parks, recreational and places of worship along the river length are prone to significant flood impact. This map serves as an input for emergency preparation programme in the event of the dam break.

Porównanie przepływów maksymalnych obliczonych w zlewni miejskiej za pomocą modeli HEC-RAS i SWMM

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Mariusz Barszcz

2016-12-01

Full Text Available W pracy przedstawiono wyniki zastosowania 3. modeli, adaptowanych dla zlewni Potoku Służewieckiego, do prognozy przepływów o prawdopodobieństwach przekroczenia 1, 2 i 10% wywołanych ulewami. Przepływy prognozowano w 4. przekrojach obliczeniowych Potoku Służewieckiego, zlokalizowanych na odcinku od km 0+000 do 6+576. Obliczone za pomocą modelu konceptualnego OTTHYMO potencjalne przepływy (spływy powierzchniowe przyjęto jako dane wejściowe do modelu hydraulicznego HEC-RAS, który umożliwił transformację przepływów w cieku i wyznaczenie przepływów w poszczególnych przekrojach obliczeniowych (przepływów zredukowanych. Niezależne obliczenia przepływów potencjalnych i zredukowanych przeprowadzono za pomocą modelu SWMM, który jest modelem dynamicznym o parametrach rozłożonych. Obliczone za pomocą modeli HEC-RAS i SWMM przepływy zredukowane o prawdopodobieństwach przekroczenia 1, 2 i 10% są do siebie podobne w przekrojach obliczeniowych II, III i IV – w 7. na 9 przypadków różnice w przepływach nie przekraczają 25%. Największe wartości przepływów zredukowanych o określonym prawdopodobieństwie przekroczenia obliczono w przekroju II, przy zastosowaniu obydwu modeli. Przepływy zredukowane są mniejsze od przepływów potencjalnych obliczonych za pomocą modeli OTTHYMO i SWMM. Wyniki obliczeń wskazują na możliwość stosowania w zlewniach miejskich zarówno modelu HEC-RAS, jak i modelu SWMM.

Refined ab initio intermolecular ground-state potential energy surface for the He-C2H2 van der Waals complex

DEFF Research Database (Denmark)

Fernández, Berta; Henriksen, Christian; Farrelly, David

2013-01-01

A refined CCSD(T) intermolecular potential energy surface is developed for the He-C2H2 van der Waals complex. For this, 206 points on the intermolecular potential energy surface, evaluated using the CCSD(T) method and the aug-cc-pVQZ basis set extended with a set of 3s3p2d1f1g midbond functions...

The HEC RAS model of regulated stream for purposes of flood risk reduction

Directory of Open Access Journals (Sweden)

Fijko Rastislav

2016-06-01

Full Text Available The work highlights the modeling of water flow in open channels using 1D mathematical model HEC-RAS in the area of interest Lopuchov village in eastern Slovakia. We created a digital model from a geodetic survey, which was used to show the area of inundation in ArcGIS software. We point out the modeling methodology with emphasis to collection of the data and their relevance for determination of boundary conditions in 3D model of the study area in GIS platform. The BIM objects can be exported to the defined model of the area. The obtained results were used for simulation of flooding. The results give to us clearly and distinctly defined areas of inundation, which we used in the processing of Cost benefit analysis. We used the developed model for stating the potential damages in flood vulnerable areas.

The HEC RAS model of regulated stream for purposes of flood risk reduction

Science.gov (United States)

Fijko, Rastislav; Zeleňáková, Martina

2016-06-01

The work highlights the modeling of water flow in open channels using 1D mathematical model HEC-RAS in the area of interest Lopuchov village in eastern Slovakia. We created a digital model from a geodetic survey, which was used to show the area of inundation in ArcGIS software. We point out the modeling methodology with emphasis to collection of the data and their relevance for determination of boundary conditions in 3D model of the study area in GIS platform. The BIM objects can be exported to the defined model of the area. The obtained results were used for simulation of flooding. The results give to us clearly and distinctly defined areas of inundation, which we used in the processing of Cost benefit analysis. We used the developed model for stating the potential damages in flood vulnerable areas.

Getting Its Ducks in a Row? Qatar Foundation's Agreement with HEC Paris and the Launch of the Qatar Foundation Management, Education and Research Centre

Science.gov (United States)

Observatory on Borderless Higher Education, 2010

2010-01-01

Last week, private, non-profit organisation the Qatar Foundation (QF) announced a partnership agreement with French business institution HEC Paris to offer executive education programmes. According to the terms of the agreement, a full-time faculty will provide executive and short certificate programmes and corporate-specific training, including…

Model of Ciliwung River Flood Diversion Tunnel Using HEC-RAS Software

Directory of Open Access Journals (Sweden)

Nugroho Joko

2018-01-01

Full Text Available As a coastal city which lies in lowland area, Jakarta is prone to flooding. One major river which flow through Jakarta is Ciliwung River. There are alternatives to reduce flood risk, such as: river capacity improvement, existing natural reservoir and polder system improvement, upstream reservoir construction, city drainage improvement, flood channel construction and flood diversion. This paper presents capacity analysis of a proposed flood diversion of Ciliwung River to Cipinang River. Cipinang River has its downstream end at Eastern Flood Canal (Kanal Banjir Timur, KBT. This diversion is based on the available capacity of KBT. A 1-D numerical hydraulic model using HEC-RAS based on a proposed design is used to assess the performance of the diversion system in any combination of upstream and downstream boundary condition. Simulations were done for steady condition. The results show that capacity of the system can be achieved for certain condition at upstream and downstream boundary. The effects at the downstream reach of Ciliwung and Cipinang River due to the diversion are also obtained.

Règim no permanent en lleres de resposta ràpida. Aplicació del model HEC-RAS

OpenAIRE

Gayá Mascaró, Antoni

2004-01-01

El model numèric HEC-RAS és una eina d'ús públic força generalitzada en els càlculs de qualsevol projecte hidràulic. L'última versió d'aquest programa inclou un mòdul de càlcul en règim no permanent del qual no es té massa experiència pel que fa a les simulacions per hidrogrames d'avinguda curts. Aquesta tesina analitza el comportament d'aquest mòdul en la modelització de l'últim tram de la llera del riu Llobregat.

A study case of Baranca drainage basin flash-floods using the hydrological model of Hec-Ras

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Aritina HALIUC

2012-09-01

Full Text Available In the last decades, the floods which occurred within Romanian territory stand as proof for the increased frequency of the extreme hydrological hazards which have negative effects on the normal pathway of the human-beings activities. The technological progress among with the increased frequency of floods events are the base for the development of informational programs for the analysis, simulation and flood management. The Baranca brook which drains a considerable part of Zamostea village (Romania was used as a pilot drainage basin for the flash-flood simulation using the Hec-Ras program and the Arcgis extension, HecGeo-Ras. The flash-floods that occurred in the summer of 2010 were used to validate the results of the simulation. Between 28.06.2010 – 29.06.2010, two flash-floods occurred in the Baranca drainage basin with a discharge oscillated between 10m3 and 70m3, a water extent which covered an area of 5.14 km2 and a depth ranging between 0.3-3m. The programs are capable to simulate the water flow and to investigate the floodway encroachments in the study area. The damages evaluated in the field along with the program’s results reveal the fact that more than half of the built-up areas of Zamostea village are established along brooks, within the floodplain area. What is more, after the 2010 floods, the expension of the habitable area was not detained by the water danger, many houses are still built on the floodplain. The programs used, taking an acceptable margin of error, may be integrated into any flood management strategy or in any watershed plan and may provide the necessary support for mitigating the risks associated with floods

Hydrologic Engineering Center River Analysis System (HEC-RAS) Water Temperature Models Developed for the Missouri River Recovery Management Plan and Environmental Impact Statement

Science.gov (United States)

2017-09-18

ER D C/ EL T R- 17 -1 8 Missouri River Recovery Program (MRRP) Hydrologic Engineering Center-River Analysis System (HEC-RAS) Water...Zhonglong Zhang and Billy E. Johnson September 2017 Approved for public release; distribution is unlimited. The U.S. Army Engineer Research...and Development Center (ERDC) solves the nation’s toughest engineering and environmental challenges. ERDC develops innovative solutions in civil and

Osteopontin Promotes Invasion, Migration and Epithelial-Mesenchymal Transition of Human Endometrial Carcinoma Cell HEC-1A Through AKT and ERK1/2 Signaling

OpenAIRE

Yinghua Li; Yunpeng Xie; Dan Cui; Yanni Ma; Linlin Sui; Chenyang Zhu; Hui Kong; Ying Kong

2015-01-01

Background/Aims: Osteopontin (OPN) is an Extracellular Matrix (ECM) molecule and is involved in many physiologic and pathologic processes, including cell adhesion, angiogenesis and tumor metastasis. OPN is a well-known multifunctional factor involved in various aspects of cancer progression, including endometrial cancer. In this study, we examined the significance of OPN in endometrial cancer. Methods: The proliferation, migration and invasion ability of HEC-1A cells were detected by Cell Cou...

Testing of the river system simulator on the river system of Stjoerdalen. Simulation of floods in the lower parts of the Stjoerdalselva with HEC-2; Utproeving av vassdragssimulatoren i Stjoerdalsvassdraget. Simulering av flomforhold i nedre deler av Stjoerdalselva med HEC-2

Energy Technology Data Exchange (ETDEWEB)

Harby, A.; Bakken, T.H.

1994-05-01

This report describes a part of the testing of a computer simulator for river systems. The simulator can be used to simulate how a river system is affected by various types of exploitation and will be especially useful for consequence analyses. The simulator has been tested on three river systems in Norway. Being one of 17 reports on the complete testing, this report concentrates on the flood conditions in the lower parts of the river Stjoerdalselva. This area is flat farm land with some risk of floods. The simulation model used is HEC-2 and should not be used if the flow pattern changes from subcritical to supercriticle flow. 3 refs., 2 figs., 3 tabs.

Análisis de amenaza, vulnerabilidad y riesgo en la cuenca alta del Río Bogotá, en el Municipio de Villapinzón, utilizando modelación hidrológica HEC-HMS e hidráulica 1D y 2D HEC-RAS e ÍBER

OpenAIRE

Vera Ruiz, Daniel Armando.

2015-01-01

Inicialmente se destaca la importancia de la zona de estudio, la cual permite evidenciar las afectaciones provocadas por fenómenos de creciente y de cómo la planeación juega un papel importante en prevenirlas. También se cita un análisis climatológico y de lluvias de la zona en estudio. En seguida se realiza un análisis hidrológico en la cuenca alta del río Bogotá en el sector de Villapinzon basado en herramientas computacionales Hec.Hms. Posteriormente se realizan modelaciones unidimensional...

Modelling rainfall runoff relations using HEC-HMS in a semi-arid region: Case study in Ain Sefra watershed, Ksour Mountains (SW Algeria)

OpenAIRE

Derdour Abdessamed; Bouanani Abderrazak; Babahamed Kamila

2018-01-01

Ain Sefra is one of the Algerian cities that had been experienced several devastating floods during the past 100 years. The purpose of this study is to simulate runoff in the semi-arid region of Ain Sefra watershed through the employing of the Hydrologic Engineering Center – Hydrologic Modelling System (HEC-HMS). In this paper, the frequency storm is used for the meteorological model, the Soil Conservation Service – curve number (SCS-CN) is selected to calculate the loss rate and Soil Conserv...

The reconstruction of a glacial lake outburst flood using HEC-RAS and its significance for future hazard assessments: an example from Lake 513 in the Cordillera Blanca, Peru

Czech Academy of Sciences Publication Activity Database

Klimeš, Jan; Benešová, M.; Vilímek, V.; Bouška, P.; Rapre, A.C.

2014-01-01

Roč. 71, č. 3 (2014), s. 1617-1638 ISSN 0921-030X R&D Projects: GA ČR(CZ) GAP209/11/1000 Institutional support: RVO:67985891 Keywords : GLOFs * debris flow * natural hazard * HEC-RAS * Cordillera Blanca Subject RIV: DE - Earth Magnetism, Geodesy, Geography Impact factor: 1.719, year: 2014

Nonstationarities in Catchment Response According to Basin and Rainfall Characteristics: Application to Korean Watershed

Science.gov (United States)

Kwon, Hyun-Han; Kim, Jin-Guk; Jung, Il-Won

2015-04-01

It must be acknowledged that application of rainfall-runoff models to simulate rainfall-runoff processes are successful in gauged watershed. However, there still remain some issues that will need to be further discussed. In particular, the quantitive representation of nonstationarity issue in basin response (e.g. concentration time, storage coefficient and roughness) along with ungauged watershed needs to be studied. In this regard, this study aims to investigate nonstationarity in basin response so as to potentially provide useful information in simulating runoff processes in ungauged watershed. For this purpose, HEC-1 rainfall-runoff model was mainly utilized. In addition, this study combined HEC-1 model with Bayesian statistical model to estimate uncertainty of the parameters which is called Bayesian HEC-1 (BHEC-1). The proposed rainfall-runofall model is applied to various catchments along with various rainfall patterns to understand nonstationarities in catchment response. Further discussion about the nonstationarity in catchment response and possible regionalization of the parameters for ungauged watershed are discussed. KEYWORDS: Nonstationary, Catchment response, Uncertainty, Bayesian Acknowledgement This research was supported by a Grant (13SCIPA01) from Smart Civil Infrastructure Research Program funded by the Ministry of Land, Infrastructure and Transport (MOLIT) of Korea government and the Korea Agency for Infrastructure Technology Advancement (KAIA).

River analysis and floodplain modeling using HEC-GeoRAS/RAS, GIS and ArcGIS: a case study for the Salinas River

Science.gov (United States)

Mishra, P. K.; Bernini Campos, H. E.

2016-12-01

The lower portion of the Salinas River in Monterey bay, California has a history of flood, lots of study has been made ab out the water quality since the river provides water for the crops around, but is still in need a detailed study about the river behavior and flood analysis. The floods did significant damage, affecting valuable landing farms, residences and businesses in Monterey County. The first step for this study is comprehend and collect the river bathymetry and surroundings and then analyze the discharge and how it is going to change with time. This thesis develops a model about the specific site, recruiting real data from GIS and performing a flow simulation according to flow data provided by USGS, to verify water surface elevation and floodplain. The ArcMap, developed by ESRI, was used along with an extension (HEC-GeoRAS) because it was indeed the most appropriate model to work with the Digital Elevation Model, develop the floodplain and characterizing the land surface accurately in the study site. The HEC-RAS software, developed by US Army Corp of Engineers, was used to compute one-dimension steady flow and two-dimension unsteady flow, providing flow velocity, water surface elevation and profiles, total surface area, head and friction loss and other characteristics, allowing the analysis of the flow. A mean discharge, a mean peak streamflow and a peak discharge were used for the steady flow and a Hydrograph was used for the unsteady flow, both are based on the 1995 flood and discharge history. This study provides important information about water surface elevation and water flow, allowing stakeholders and the government to analyze solutions to avoid damage to the society and landowners.

MEASURING THE ULTIMATE HALO MASS OF GALAXY CLUSTERS: REDSHIFTS AND MASS PROFILES FROM THE HECTOSPEC CLUSTER SURVEY (HeCS)

International Nuclear Information System (INIS)

Rines, Kenneth; Geller, Margaret J.; Kurtz, Michael J.; Diaferio, Antonaldo

2013-01-01

The infall regions of galaxy clusters represent the largest gravitationally bound structures in a ΛCDM universe. Measuring cluster mass profiles into the infall regions provides an estimate of the ultimate mass of these halos. We use the caustic technique to measure cluster mass profiles from galaxy redshifts obtained with the Hectospec Cluster Survey (HeCS), an extensive spectroscopic survey of galaxy clusters with MMT/Hectospec. We survey 58 clusters selected by X-ray flux at 0.1 200 , a new observational cosmological test in essential agreement with simulations. Summed profiles binned in M 200 and in L X demonstrate that the predicted Navarro-Frenk-White form of the density profile is a remarkably good representation of the data in agreement with weak lensing results extending to large radius. The concentration of these summed profiles is also consistent with theoretical predictions.

Diacylglycerol kinase α mediates 17-β-estradiol-induced proliferation, motility, and anchorage-independent growth of Hec-1A endometrial cancer cell line through the G protein-coupled estrogen receptor GPR30.

Science.gov (United States)

Filigheddu, Nicoletta; Sampietro, Sara; Chianale, Federica; Porporato, Paolo E; Gaggianesi, Miriam; Gregnanin, Ilaria; Rainero, Elena; Ferrara, Michele; Perego, Beatrice; Riboni, Francesca; Baldanzi, Gianluca; Graziani, Andrea; Surico, Nicola

2011-12-01

Increased levels of endogenous and/or exogenous estrogens are one of the well known risk factors of endometrial cancer. Diacylglycerol kinases (DGKs) are a family of enzymes which phosphorylate diacylglycerol (DAG) to produce phosphatidic acid (PA), thus turning off and on DAG-mediated and PA-mediated signaling pathways, respectively. DGK α activity is stimulated by growth factors and oncogenes and is required for chemotactic, proliferative, and angiogenic signaling in vitro. Herein, using either specific siRNAs or the pharmacological inhibitor R59949, we demonstrate that DGK α activity is required for 17-β-estradiol (E2)-induced proliferation, motility, and anchorage-independent growth of Hec-1A endometrial cancer cell line. Impairment of DGK α activity also influences basal cell proliferation and growth in soft agar of Hec-1A, while it has no effects on basal cell motility. Moreover, we show that DGK α activity induced by E2, as well as its observed effects, are mediated by the G protein-coupled estrogen receptor GPR30 (GPER). These findings suggest that DGK α may be a potential target in endometrial cancer therapy. Copyright © 2011 Elsevier Inc. All rights reserved.

KARAKTERISTIK DAN STABILITAS SEDIAAN GEL MULUT BERBAHAN AKTIF EKSTRAK DAUN SIRIH HITAM BERBASIS HYDROXY ETHYL CELLULOSE (HEC

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Fajar Prasetya

2013-06-01

Full Text Available This study aimed to obtain mouth gel formula ​​from extract of black betel leaves which effectively kill microbes that cause inflammation of the gums (gingivitis and tooth decay (caries. The mouth gel formulation ​​from black betel leaves extract has been made by various concentrate of Hydroxy Ethyl Cellulose (HEC as a mucoadhesive polymer. The optimized mouth gel base determine by evaluation the physical which includes organoleptic, viscosity, pH, the spreadability, and consistency after 16 days storage. The evaluation test was done with pH 7.21 (which lowest - 7.78 (the highest. The spreadability after 16 days storage of 50 grams for formula 1, formula 2, formula 3 each is 11.33 cm, 5.60 cm, and 4.70 cm. The consistency of the mouth gel formulation ​​from black betel leaves extract on formula 1, formula 2, and formula 3 are no changes occurred up to 16 days of storage. The viscosity obtained after 16 days of storage for formula 1, formula 2, and formula 3 respectively are 4.30 dpas, 37 dpas, and 80 dpas. The result showed that formula 2 has better formulation. Keywords: antimicrobials ,mouth gel, black betel, gingivitis, cavities ABSTRAK Penelitian ini bertujuan untuk mendapatkan formula gel mulut dari ekstrak daun sirih hitam yang secara efektif membunuh mikroba yang menyebabkan peradangan pada gusi (gingivitis dan kerusakan gigi (karies. Formulasi gel mulut dari hitam sirih ekstrak daun telah dibuat oleh berbagai konsentrasi Hidroksi Etil Selulosa (HEC sebagai polimer mukoadhesif. Dioptimalkan basis gel mulut menentukan dengan evaluasi fisik yang meliputi organoleptik, viskositas, pH, spreadability, dan konsistensi setelah 16 hari penyimpanan. Tes evaluasi dilakukan dengan pH 7.21 (yang terendah - 7.78 (tertinggi. The spreadability setelah 16 hari penyimpanan 50 gram untuk formula 1, rumus 2, rumus 3 masing-masing adalah 11,33 cm, 5,60 cm, dan 4,70 cm. Konsistensi formulasi gel mulut dari daun sirih hitam ekstrak formula 1, rumus

Physicochemical properties of pH-sensitive hydrogels based on hydroxyethyl cellulose-hyaluronic acid and for applications as transdermal delivery systems for skin lesions.

Science.gov (United States)

Kwon, Soon Sik; Kong, Bong Ju; Park, Soo Nam

2015-05-01

We investigated the physicochemical properties of pH-sensitive hydroxyethyl cellulose (HEC)/hyaluronic acid (HA) complex hydrogels containing isoliquiritigenin (ILTG), and discussed potential applications as transdermal delivery systems for the treatment of skin lesions caused by pH imbalance. HA has skin compatibility and pH functional groups and HEC serves as scaffold to build hydrogels with varied HCE:HA mass ratio. Hydrogels were synthesized via chemical cross-linking, and three-dimensional network structures were characterized via scanning electron microscopy (SEM). The swelling properties and polymer ratios of the hydrogels were investigated at pH values in the range 1-13. HECHA13 (i.e., an HEC:HA mass ratio of 1:3) was found to have optimal rheological and adhesive properties, and was used to investigate the drug release efficiency as a function of pH; the efficiency was greater than 70% at pH 7. Antimicrobial activity assays against Propionibacterium acnes were conducted to take advantage of the pH-sensitive properties of HECHA13. At pH 7, we found that HECHA13, which contained ILTG, inhibited the growth of P. acnes. Furthermore, HECHA13 was found to exhibit excellent permeability into the skin, which penetrated mostly via the hair follicle. These results indicate that this pH-sensitive hydrogel is effective as a transdermal delivery system for antimicrobial therapeutics, with potential applications in the treatment of acne. Copyright © 2015 Elsevier B.V. All rights reserved.

State of Flood Related Modeling Along Middle Rio Grande: Report Documentary 2007-2008 Work

Science.gov (United States)

2010-07-01

Bosque Environment (CBE) Title Prepared By Rio Grande Silvery Minnow Sanctuary Proposed Site, 1-D HEC - RAS Model of Area of Interest Jonathan Acbuchon...Erosion Jennifer G. Duan Case Study: Application of the HEC -6 Model for the Main Stem of the Kankakee River in Illinois Nani G. Bhowmik, D.WRE...1 bank-attached bar HYDRAULIC ANALYSIS One-dimensional HEC - RAS models – Fixed-bed analysis – Calibrated to gauged flow at time of survey and 2005

Numerical Limitations of 1D Hydraulic Models Using MIKE11 or HEC-RAS software - Case study of Baraolt River, Romania

Science.gov (United States)

Andrei, Armas; Robert, Beilicci; Erika, Beilicci

2017-10-01

MIKE 11 is an advanced hydroinformatic tool, a professional engineering software package for simulation of one-dimensional flows in estuaries, rivers, irrigation systems, channels and other water bodies. MIKE 11 is a 1-dimensional river model. It was developed by DHI Water · Environment · Health, Denmark. The basic computational procedure of HEC-RAS for steady flow is based on the solution of the one-dimensional energy equation. Energy losses are evaluated by friction and contraction / expansion. The momentum equation may be used in situations where the water surface profile is rapidly varied. These situations include hydraulic jumps, hydraulics of bridges, and evaluating profiles at river confluences. For unsteady flow, HEC-RAS solves the full, dynamic, 1-D Saint Venant Equation using an implicit, finite difference method. The unsteady flow equation solver was adapted from Dr. Robert L. Barkau’s UNET package. Fluid motion is controlled by the basic principles of conservation of mass, energy and momentum, which form the basis of fluid mechanics and hydraulic engineering. Complex flow situations must be solved using empirical approximations and numerical models, which are based on derivations of the basic principles (backwater equation, Navier-Stokes equation etc.). All numerical models are required to make some form of approximation to solve these principles, and consequently all have their limitations. The study of hydraulics and fluid mechanics is founded on the three basic principles of conservation of mass, energy and momentum. Real-life situations are frequently too complex to solve without the aid of numerical models. There is a tendency among some engineers to discard the basic principles taught at university and blindly assume that the results produced by the model are correct. Regardless of the complexity of models and despite the claims of their developers, all numerical models are required to make approximations. These may be related to geometric

Design and synthesis of a novel cationic thiolated polymer.

Science.gov (United States)

Rahmat, Deni; Sakloetsakun, Duangkamon; Shahnaz, Gul; Perera, Glen; Kaindl, Reinhard; Bernkop-Schnürch, Andreas

2011-06-15

The purpose of this study was to design and characterize a novel cationic thiolated polymer. In this regard a hydroxyethylcellulose-cysteamine conjugate (HEC-cysteamine) was synthesized. Oxidative ring opening with periodate and reductive amination with cysteamine were performed in order to immobilize free thiol groups to HEC. The resulting HEC-cysteamine displayed 2035 ± 162 μmol immobilized free thiol groups and 185 ± 64 μmol disulfide bonds per gram of polymer being soluble in both acidic and basic conditions. Unlike the unmodified HEC, in case of HEC-cysteamine, a three-fold increase in the viscosity was observed when equal volumes of the polymer were mixed with mucin solution. Tablets based on HEC-cysteamine remained attached on freshly excised porcine mucosa for 8 0h and displayed increased disintegration time of 2h. Swelling behavior of HEC-cysteamine tablets in 0.1M phosphate buffer pH 6.8 indicated swelling ratio of 19 within 8h. In contrast, tablets comprising unmodified HEC detached from the mucosa within few seconds and immediately disintegrated. In addition, they did not exhibit swelling behavior. The transport of rhodamine 123 across freshly excised rat intestine enhanced by a value of approximately 1.6-fold (p-value = 0.0024) in the presence of 0.5% (m/v) HEC-cysteamine as compared to buffer control. Result from cytotoxicity test of HEC-cysteamine applied to Caco-2 cells in concentration of 0.5% (m/v) revealed 82.4 ± 4.60% cell viability. According to these results, HEC-cysteamine seems to be a promising polymer for various pharmaceutical applications especially for intestinal drug delivery. Copyright © 2011. Published by Elsevier B.V.

Uso de traçadores fluorescentes para determinar características de transporte e dispersão no Rio Piabanha (RJ para a modelagem quali-quantitativa pelo HEC-RAS

Directory of Open Access Journals (Sweden)

Paulo Vitor Ribeiro Marques da Silva

Full Text Available RESUMO Um estudo de campo foi realizado em um trecho de aproximadamente 70 km do rio Piabanha, localizado entre Petrópolis e Areal, na região serrana do Estado do Rio de Janeiro, para estimar as características de transporte e dispersão de contaminantes usando técnicas de traçadores fluorescentes. A análise dos resultados de dois trabalhos de campo, realizados no outono de 2012, permitiu determinar os valores de tempo de trânsito, vazão líquida, velocidade média e coeficiente de dispersão longitudinal. Utilizou-se os dados de vazão e velocidade média obtidos nos ensaios com traçadores para calibrar o modelo hidrodinâmico unidimensional Hydrologic Engineering Center’s River Analysis System (HEC-RAS. Considerando que parâmetros hidráulicos obtidos por métodos clássicos em rios com geometria muito irregular, como a do rio Piabanha, não são adequados para representar as características médias de um trecho, os ensaios com traçadores representaram uma boa alternativa para obtenção de parâmetros necessários a modelos hidrodinâmicos. Os resultados obtidos pelo modelo HEC-RAS apresentaram ótima concordância com os dados obtidos por meio dos ensaios com traçadores fluorescentes.

Modeling Hydrologic Processes after Vegetation Restoration in an Urban Watershed with HEC-HMS

Science.gov (United States)

Stevenson, K.; Kinoshita, A. M.

2017-12-01

The San Diego River Watershed in California (USA) is highly urbanized, where stream channel geomorphology are directly affected by anthropogenic disturbances. Flooding and water quality concerns have led to an increased interest in improving the condition of urban waterways. Alvarado Creek, a 1200-meter section of a tributary to the San Diego River will be used as a case study to understand the degree to which restoration efforts reduce the impacts of climate change and anthropogenic activities on hydrologic processes and water quality in urban stream ecosystems. In 2016, non-native vegetation (i.e. Washingtonia spp. (fan palm), Phoenix canariensis (Canary Island palm)) and approximately 7257 kilograms of refuse were removed from the study reach. This research develops the United States Army Corp of Engineers Hydrologic Engineering Center's Hydraulic Modeling System (USACE HEC-HMS) using field-based data to model and predict the short- and long-term impacts of restoration on geomorphic and hydrologic processes. Observations include cross-sectional area, grain-size distributions, water quality, and continuous measurements of streamflow, temperature, and precipitation. Baseline and design storms are simulated before and after restoration. The model will be calibrated and validated using field observations. The design storms represent statistical likelihoods of storms occurrences, and the pre- and post-restoration hydrologic responses will be compared to evaluate the impact of vegetation and waste removal on runoff processes. Ultimately model parameters will be transferred to other urban creeks in San Diego that may potentially undergo restoration. Modeling will be used to learn about the response trajectory of rainfall-runoff processes following restoration efforts in urban streams and guide future management and restoration activities.

Stability Thresholds and Performance Standards for Flexible Lining Materials in Channel and Slope Restoration Applications

Science.gov (United States)

2012-07-01

number method, hydraulic modeling (e.g., HEC -15, HEC - RAS ), or evaluation of historical gage records or flood frequency distributions. The materials used...Recommendations for product selection and field installation monitoring are summarized. INTRODUCTION: Conventional river engineering and stream... river engineering. New York: John Wiley and Sons. Citing Fortier, S., and F. C. Scobey. 1926. Permissible canal velocities. In Transactions of the ASCE

Scoping Assessment for Developing a Water Quality Monitoring Plan to Support Application of the CE-QUAL-W2 Hydrodynamic and Water Quality Model to the Lower Missouri River downstream of Gavins Point Dam

Science.gov (United States)

2010-04-01

setting up input geometry for the Missouri River : 1) channel geometry will be obtained from previous HEC - RAS modeling of the lower Missouri River , and 2...stage-discharge rating curves developed for USGS and USACE gaging stations on the Missouri River . HEC - RAS (Hydrologic Engineering Center- River ...adjusted to better match the “project” table. For the lower Missouri River , initial cell widths will be derived from past HEC - RAS modeling

Modelling rainfall runoff relations using HEC-HMS in a semi-arid region: Case study in Ain Sefra watershed, Ksour Mountains (SW Algeria

Directory of Open Access Journals (Sweden)

Derdour Abdessamed

2018-03-01

Full Text Available Ain Sefra is one of the Algerian cities that had been experienced several devastating floods during the past 100 years. The purpose of this study is to simulate runoff in the semi-arid region of Ain Sefra watershed through the employing of the Hydrologic Engineering Center – Hydrologic Modelling System (HEC-HMS. In this paper, the frequency storm is used for the meteorological model, the Soil Conservation Service – curve number (SCS-CN is selected to calculate the loss rate and Soil Conservation Service unit hydrograph method have been applied to simulate the runoff rate. After calibration and validation, the simulated peak discharges were very close with observed values. The Nash–Sutcliffe efficiency coefficient was 0.95, indicates that the hydrological modeling results are satisfactory and accepted for simulation of rainfall-runoff. The peak discharges obtained for the 10, 50, 100 and 1000 year storms are respectively 425.8, 750.5, 904.3 and 1328.3 m3∙s−1.

Health-e-Child: a grid platform for european paediatrics

International Nuclear Information System (INIS)

Skaburskas, K; Estrella, F; Shade, J; Manset, D; Revillard, J; Rios, A; Anjum, A; Branson, A; Bloodsworth, P; Hauer, T; McClatchey, R; Rogulin, D

2008-01-01

The Health-e-Child (HeC) project [1], [2] is an EC Framework Programme 6 Integrated Project that aims to develop a grid-based integrated healthcare platform for paediatrics. Using this platform biomedical informaticians will integrate heterogeneous data and perform epidemiological studies across Europe. The resulting Grid enabled biomedical information platform will be supported by robust search, optimization and matching techniques for information collected in hospitals across Europe. In particular, paediatricians will be provided with decision support, knowledge discovery and disease modelling applications that will access data in hospitals in the UK, Italy and France, integrated via the Grid. For economy of scale, reusability, extensibility, and maintainability, HeC is being developed on top of an EGEE/gLite [3] based infrastructure that provides all the common data and computation management services required by the applications. This paper discusses some of the major challenges in bio-medical data integration and indicates how these will be resolved in the HeC system. HeC is presented as an example of how computer science (and, in particular Grid infrastructures) originating from high energy physics can be adapted for use by biomedical informaticians to deliver tangible real-world benefits

Thiolated hydroxyethylcellulose: synthesis and in vitro evaluation.

Science.gov (United States)

Sarti, Federica; Staaf, Alexander; Sakloetsakun, Duangkamon; Bernkop-Schnürch, Andreas

2010-11-01

In recent years, thiomers have received considerable interest due to advantageous characteristics, such as improved mucoadhesive and permeation enhancing properties. Thiolated polymers, however, are characterized by an ionic charge which represents for various applications a great limitation. The aim of this study was therefore to synthesize a novel thiolated polymer not exhibiting ionizable groups. Hydroxyethylcellulose (HEC) was chosen as polymer backbone. The chemical modification was achieved by the replacement of hydroxyl groups on the carbohydrate structure with thiol moieties, using thiourea as thiolating reagent. The resulting thiolated hydroxyethylcellulose (HEC-SH) was characterized in vitro regarding its gelling properties, swelling behaviour, mucoadhesion on freshly excised porcine intestinal mucosa and permeation enhancing effect across rat intestinal mucosa. The new thiomer displayed up to 131.58 ± 11.17 μmol thiol groups per gram polymer, which are responsible for the observed in situ gelling capacity. The swelling behaviour and the mucoadhesive properties of tablets based on HEC-SH were 1.5-fold and 4-fold improved compared with unmodified HEC, respectively. The permeation enhancing effect of 0.5% (m/v) HEC-SH on rhodamine 123 (Rho-123) transport was 1.9-fold improved compared with buffer only. According to these results, HEC-SH seems to represent a promising tool for the development of in situ gelling, mucoadhesive delivery systems with permeation enhancing properties. Copyright © 2010 Elsevier B.V. All rights reserved.

Flash Flood Prediction by Coupling KINEROS2 and HEC-RAS Models for Tropical Regions of Northern Vietnam

Directory of Open Access Journals (Sweden)

Hong Quang Nguyen

2015-11-01

Full Text Available Northern Vietnam is a region prone to heavy flash flooding events. These often have devastating effects on the environment, cause economic damage and, in the worst case scenario, cost human lives. As their frequency and severity are likely to increase in the future, procedures have to be established to cope with this threat. As the prediction of potential flash floods represents one crucial element in this circumstance, we will present an approach that combines the two models KINEROS2 and HEC-RAS in order to accurately predict their occurrence. We used a documented event on 23 June 2011 in the Nam Khat and the larger adjacent Nam Kim watershed to calibrate the coupled model approach. Afterward, we evaluated the performance of the coupled models in predicting flow velocity (FV, water levels (WL, discharge (Q and streamflow power (P during the 3–5 days following the event, using two different precipitation datasets from the global spectral model (GSM and the high resolution model (HRM. Our results show that the estimated Q and WL closely matched observed data with a Nash–Sutcliffe simulation efficiency coefficient (NSE of around 0.93 and a coefficient of determination (R2 at above 0.96. The resulting analyses reveal strong relationships between river geometry and FV, WL and P. Although there were some minor errors in forecast results, the model-predicted Q and WL corresponded well to the gauged data.

Influence of core model parameters on the characteristics of neutron beams of the research reactor

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N. A. Khafizova

2013-12-01

Full Text Available IRT MEPhI reactor is equipped with a number of facilities at horizontal experimental channels (HEC. Knowing of parameters influencing spatio-angular distribution of irradiation fields is essential for each application area. The research for neutron capture therapy (NCT facility at HEC of the reactor was made. Calculation methods have been used to estimate how the reactor core parameters influence neutron beam characteristics at the HEC output. The impact of neutron source model in Monte Carlo calculations by MCNP code on the parameters of neutron and secondary photon field at the output of irradiation beam tubes of research reactor is estimated. The study shows that specifying neutron source with fission reaction rate distribution in SDEF option gives almost the same results as criticality calculation considered the most accurate. Our calculations show that changes of the core operational parameters have insignificant influence on characteristics of neutron beams at HEC output.

Soluble CD54 induces human endothelial cells ex vivo expansion useful for cardiovascular regeneration and tissue engineering application

KAUST Repository

Malara, N.M.

2015-03-01

Aim: Consistent expansion of primary human endothelial cells in vitro is critical in the development of engineered tissue. A variety of complex culture media and techniques developed from different basal media have been reported with alternate success. Incongruous results are further confounded by donor-to-donor variability and cellular source of derivation. Our results demonstrate how to overcome these limitations using soluble CD54 (sCD54) as additive to conventional culture medium. Methods and results: Isolated primary fragment of different vessel types was expanded in Ham\\'s F12 DMEM, enriched with growth factors, Fetal Calf Serum and conditioned medium of Human Umbilical Vein Endothelial Cells (HUVEC) collected at different passages. Cytokine content of culture media was analyzed in order to identify the soluble factors correlating with better proliferation profile. sCD54 was found to induce the in vitro expansion of human endothelial cells (HECs) independently from the vessels source and even in the absence of HUVEC-conditioned medium. The HECs cultivated in the presence of sCD54 (50 ng/ml), resulted positive for the expression of CD146 and negative for CD45, and lower fibroblast contamination. Cells were capable to proliferate with an S phase of 25%, to produce vascular endothelial growth factor, VEGF, (10 ng/ml) and to give origin to vessel-like tubule in vitro. Conclusion: Our results demonstrate that sCD54 is an essential factor for the in-vitro expansion of HECs without donor and vessel-source variability. Resulting primary cultures can be useful, for tissue engineering in regenerative medicine (e.g. artificial micro tissue generation, coating artificial heart valve etc.) and bio-nanotechnology applications. © 2015 The Authors. Published by Elsevier Ireland Ltd.

DETERMINAÇÃO DO LIMITE DA FAIXA DE INUNDAÇÃO COM USO DO HEC-RAS PARA O PARQUE LINEAR DO CÓRREGO MACAMBIRA EM GOIÂNIA, GOIÁS (doi:10.5216/reec.V11i1.32101

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Fernanda Almeida de Oliveira

2016-02-01

Full Text Available RESUMO: O presente trabalho teve por objetivo delimitar as áreas inundáveis do Córrego Macambira para implantação de um parque linear. Esse curso d'água é objeto de um projeto denominado Programa Urbano Ambiental Macambira-Anicuns com a finalidade de transformar as margens de dois córregos em um parque para população do município de Goiânia-GO. O curso d'água em questão, não diferente dos outros presentes na área urbana, atualmente se encontra degradado e com as áreas de várzea ocupadas desordenadamente por habitações, comércios, pequenas plantações e indústrias. Para a delimitação do perímetro máximo do parque, sua área de abrangência, foi necessário um estudo hidrodinâmico com a delimitação da faixa de inundação das margens do córrego urbano Macambira, em Goiânia, utilizando topografia de alta resolução e o software HEC-RAS. De forma geral, a mancha de inundação obtida para a área em estudo apresentou estar dentro da calha natural inundável do curso d'água na maior parte do tempo. No entanto, alguns pontos ocorrem transbordamentos, que atingem as ruas e locais de áreas habitadas, podendo chegar a até 70 metros a partir da calha natural. Dessa forma, a modelagem por HEC-RAS permitiu contemplar o diagnóstico atual do funcionamento hidrodinâmico do sistema de drenagem do Córrego Macambira com foco no comportamento hidráulico da calha de drenagem existente, servindo de base para o projeto, para que se posa estabelecer estratégias de intervenções eficazes mais apropriadas para cada situação. ABSTRACT: This study aimed to define the flood inundation area of the stream Macambira to implement a linear park. This stream is the subject of a project called Urban Environmental Program-Macambira Anicuns, which aims to transform the banks of these two streams in a public park for the city of Goiania. The stream in question, not different from the others in the urban area, is currently degraded and the

Final Independent External Peer Review Report, Cache la Poudre at Greeley, Colorado General Investigation Feasibility Study

Science.gov (United States)

2014-06-06

Analysis HEC -HMS Hydrologic Engineering Center-Hydrologic Modeling System HEC - RAS Hydrologic Engineering Center-River Analysis System HEP Habitat...ecosystem restoration measures X Proficient with HEC models in particular HEC -Hydrologic Modeling System (HMS) and HEC - River Analysis System ( RAS ...over 100 floodplain studies, nearly all of which were completed using the Hydrologic Engineering Center-River Analysis System ( HEC - RAS ) (or HEC -2

Modeling the Hydrodynamics and Water Quality of the Lower Minnesota River Using CE-QUAL-W2: A Report on the Development, Calibration, Verification, and Application of the Model

Science.gov (United States)

2012-05-01

bathymetry file for the LMRM was originally developed from a former bathymetry file used for a HEC - RAS model developed for the lower Minnesota...River by the USACE, St. Paul District. The HEC - RAS model’s grid consisted of cross-section data for RM 0.0 to RM 36.3. The data used for RM 0-15

Liposomes coated with hydrophobically modified hydroxyethyl cellulose: Influence of hydrophobic chain length and degree of modification.

Science.gov (United States)

Smistad, Gro; Nyström, Bo; Zhu, Kaizheng; Grønvold, Marthe Karoline; Røv-Johnsen, Anne; Hiorth, Marianne

2017-08-01

Nanoparticulate systems with an uncharged hydrophilic surface may have a great potential in mucosal drug delivery. In the present study liposomes were coated with hydrophobically modified hydroxyethyl cellulose (HM-HEC) to create a sterically stabilized liposomal system with an uncharged surface. The aim was to clarify the influence of the amount of hydrophobic modification of HEC and the length of the hydrophobic moiety, on the stability of the system and on the release properties. HM-HEC with different degrees of hydrophobic modification (1 and 2mol%) and hydrophobic groups with different chain lengths (C8, C12, C16) were included in the study, as well as fluid phase and gel phase liposomes. Both types of liposomes were successfully coated with HM-HEC containing 1mol% of hydrophobic groups, while 2mol% did not work for the intended pharmaceutical applications. The polymer coated gel phase liposomes were stable (size, zeta potential, leakage) for 24 weeks at 4°C, with no differences between the C8 and C16 HM-HEC coating. For the fluid phase liposomes a size increase was observed after 24 weeks at 4°C for all formulations; the C8 HM-HEC coated liposomes increased the most. No differences in the leakage during storage at 4°C or in the release at 35°C were observed between the fluid phase formulations. To conclude; HM-HEC with a shorter hydrophobic chain length resulted in a less stable product for the fluid phase liposomes, while no influence of the chain length was observed for the gel phase liposomes (1mol% HM). Copyright © 2017 Elsevier B.V. All rights reserved.

Final Independent External Peer Review Report for the Intake Diversion Dam Modification Lower Yellowstone Project, Montana Draft Supplement to the 26 April 2010 Environmental Assessment and Appendices

Science.gov (United States)

2013-02-08

FONSI Finding of No Significant Impact G.E. General Engineer HEC -HMS Hydrologic Engineering Center–Hydrologic Modeling System HEC - RAS Hydrologic...with HEC - RAS 4.0 (Hydrologic Engineering Center-River Analysis System) and similar USACE hydrologic and hydraulic computer models x...including Hydrologic Engineering Center-River Analysis System ( HEC - RAS ) 4.0, and has project experience using HEC -1, HEC -2, and HEC -Hydrologic Modeling

Photos from MPI: Module installation at CERN for 1999 Test Beam

CERN Multimedia

1999-01-01

Photo1 - Three HEC-1 modules after mating in the clean room. Photo2 - Close-up of three HEC-1 modules in the clean room when mounting the PSB boards. Photo3 - Three HEC-2 modules being inserted into the test-beam cryostat. Photo4 - Three HEC-2 modules in the test-beam cryostat. Photo5 - Three HEC-1 and three HEC-2 modules in the test-beam cryostat. Photo6 - Three HEC-1 and three HEC-2 modules in the test-beam cryostat.

Flood Discharge Analysis with Nakayasu Method Using Combination of HEC-RAS Method on Deli River in Medan City

Science.gov (United States)

Harahap, Rumilla; Jeumpa, Kemala; Hadibroto, Bambang

2018-03-01

The problem in this research is how in the rainy season the water does not overflow, does not occur flood and during the dry season does not occur drought so it can adjust the condition or existence of Deli river which is around Medan city. Deli River floods often occur, either caused by a smaller capacity than the existing discharge, lack of maintenance and drainage and disposal systems that do not fit with the environment, resulting in flood subscriptions every year. The purpose of this research is to know flood discharge at Deli river as Flood control in Medan city. This research is analyzed on several methods such as log Pearson, Gumbel and hydrograph unit, while HEC-RAS method is modeling conducted in analyzing the water profile of the Deli River. Furthermore, the calculation of the periodic flood discharge using the Nakayasu Method. Calculation result at Deli River return period flood discharge 2 years with an area of 14.8 km2 annual flood hydrograph the total is 26.79 m3/sec on the hours at the 4th time. Return period flood discharge 5 years with an area of 14.8 km2 annual flood hydrograph the total is 73,44 m3/sec. While 25 annual return period total flood hydrograph is 146.50 m3/sec. With flood analysis can reduce and minimize the risk of losses and land can be mapped if in the area there is flooding.

Global positioning system derived performance measures are responsive indicators of physical activity, disease and the success of clinical treatments in domestic dogs.

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Elizabeth A Bruno

Full Text Available To assess the use of Global Positioning System receiver (GPS derived performance measures for differentiating between: 1 different outdoor activities in healthy dogs; 2 healthy dogs and those with osteoarthritis; 3 osteoarthritic dogs before and after treatment with non-steroidal anti-inflammatory analgesia.Prospective study.Ten healthy dogs and seven dogs with osteoarthritis of the elbow joint (OA dogs.Healthy dogs were walked on a standard route on-lead, off-lead and subjected to playing activity (chasing a ball whilst wearing a GPS collar. Each dog was walked for five consecutive days. Dogs with OA were subjected to a single off-lead walk whilst wearing a GPS collar, and then administered oral Carprofen analgesia daily for two weeks. OA dogs were then subjected to the same walk, again wearing a GPS collar.GPS derived measures of physical performance could differentiate between on-lead activity, off-lead activity and playing activity in healthy dogs, and between healthy dogs and OA dogs. Variation in the performance measures analysed was greater between individual dogs than for individual dogs on different days. Performance measures could differentiate healthy dogs from OA dogs. OA Dogs treated with Carprofen analgesia showed improvements in their physical performance, which returned to values indistinguishable from those of healthy dogs on nearly all the measures assessed.GPS derived measures of physical performance in dogs are objective, easy to quantify, and can be used to gauge the effects of disease and success of clinical treatments. Specific stimuli can be used to modulate physical performance beyond the self-governed boundaries that dogs will naturally express when allowed to exercise freely without stimulation.

Application of Muskingum routing method with variable parameters in ungauged basin

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Xiao-meng Song

2011-03-01

Full Text Available This paper describes a flood routing method applied in an ungauged basin, utilizing the Muskingum model with variable parameters of wave travel time K and weight coefficient of discharge x based on the physical characteristics of the river reach and flood, including the reach slope, length, width, and flood discharge. Three formulas for estimating parameters of wide rectangular, triangular, and parabolic cross sections are proposed. The influence of the flood on channel flow routing parameters is taken into account. The HEC-HMS hydrological model and the geospatial hydrologic analysis module HEC-GeoHMS were used to extract channel or watershed characteristics and to divide sub-basins. In addition, the initial and constant-rate method, user synthetic unit hydrograph method, and exponential recession method were used to estimate runoff volumes, the direct runoff hydrograph, and the baseflow hydrograph, respectively. The Muskingum model with variable parameters was then applied in the Louzigou Basin in Henan Province of China, and of the results, the percentages of flood events with a relative error of peak discharge less than 20% and runoff volume less than 10% are both 100%. They also show that the percentages of flood events with coefficients of determination greater than 0.8 are 83.33%, 91.67%, and 87.5%, respectively, for rectangular, triangular, and parabolic cross sections in 24 flood events. Therefore, this method is applicable to ungauged basins.

Numerical simulations in the Mala Nitra stream by 1D model

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Lenka Szomorová

2015-06-01

Full Text Available The development of the computer technologies enables us to solve the ecological problems in water management practice very efficiently. Hydrodynamical models which simulating transport of pollution in surface water are very demanding on input data and calculation time, but on the other side, they are able to simulate detailed effect of dispersion in surface waters. The paper deals with 1-dimensional numerical model HEC-RAS and its response on various values of dispersion coefficient. This parameter is one of the most important input data for simulation of pollution spreading in streams. Getting fair value, however, is in practice very difficult. One option is the most accurate simulation of tracer experiments carried out on the ground on the natural surface flow. For the pilot application was selected flow Small Nitra. Of longitudinal dispersion coefficient in the flow, or the flow of a similar nature (with and limit the rate of flow, were in the range 0.05 to 2.5 m2 · s–1. The next task was carrying out the model sensitivity analysis, which means to evaluate input data influences, especially longitudinal dispersion coefficient, on outputs computed by 1-dimensional simulation model HEC-RAS. Sensitivity analysis model HEC-RAS also showed its adequate response to changes of the input parameter. Given the present results it can be stated that the HEC-RAS model responds to changes in the values of the longitudinal dispersion coefficient appropriately. HEC-RAS model has demonstrated its applicability to simulation of pollution in streams, and therefore is an appropriate tool for decision making related to the quality of water resources.

Growth of MCF-7 breast cancer cells and efficacy of anti-angiogenic agents in a hydroxyethyl chitosan/glycidyl methacrylate hydrogel.

Science.gov (United States)

Wang, Hejing; Qian, Junmin; Zhang, Yaping; Xu, Weijun; Xiao, Juxiang; Suo, Aili

2017-01-01

-GMA hydrogel may offer an improved platform to minimize the gap between traditional tissue culture plates and clinical applicability. In addition, the anti-angiogenic efficacy of drugs such as Endostar and Bevacizumab can be more comprehensively studied and assessed in HECS-GMA hydrogels.

The effect of watershed scale on HEC-HMS calibrated parameters: a case study in the Clear Creek watershed in Iowa, US

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H. L. Zhang

2013-07-01

Full Text Available In this paper, we use the Hydrologic Modeling System (HEC-HMS to simulate two flood events to investigate the effect of watershed subdivision in terms of performance, the calibrated parameter values, the description of hydrologic processes, and the subsequent interpretation of water balance components. We use Stage IV hourly NEXRAD precipitation as the meteorological input for ten model configurations with variable sub-basin sizes. Model parameters are automatically optimized to fit the observed data. The strategy is implemented in Clear Creek Watershed (CCW, which is located in the upper Mississippi River basin. Results show that most of the calibrated parameter values are sensitive to the basin partition scheme and that the relative relevance of physical processes, described by the model, change depending on watershed subdivision. In particular, our results show that parameters derived from different model implementations attribute losses in the system to completely different physical phenomena without a notable effect on the model's performance. Our work adds to the body of evidence demonstrating that automatically calibrated parameters in hydrological models can lead to an incorrect prescription of the internal dynamics of runoff production and transport. Furthermore, it demonstrates that model implementation adds a new dimension to the problem of non-uniqueness in hydrological models.

Developing Sediment Transport and Dredging Prediction Model of Ohio River at Olmsted Locks and Dams Area using HEC-RAS (1D/2D)By Ganesh Raj Ghimire1 and Bruce A. Devantier 2

Science.gov (United States)

Ghimire, G. R.

2015-12-01

Sediment deposition is a serious issue in the construction and operation of large reservoir and inland navigation projects in the United States and around the world. Olmsted Locks and Dams in the Ohio River navigation system is facing similar challenges of huge sediment deposition during the ongoing in-wet construction methodology since 1993. HEC-RAS 5.0 integrated with ArcGIS, will be used to yield unsteady 2D hydrodynamic model of Ohio River at Olmsted area. Velocity, suspended sediment, bed sediment and hydrographic survey data acquired from public archives of USGS and USACE Louisville District will be input into the model. Calibration and validation of model will be performed against the measured stage, flow and velocity data. It will be subjected to completely unsteady 1D sediment transport modeling new to HEC-RAS 5.0 which incorporates sediment load and bed gradation via a DSS file, commercial dredging and BSTEM model. Sediment model will be calibrated to replicate the historical bed volume changes. Excavated cross-sections at Olmsted area will also be used to predict the sediment volume trapped inside the ditch over the period between excavations and placement of dam shells at site. Model will attempt to replicate historical dredging volume data and compare with the deposition volume from simulation model to formulate the dredging prediction model. Hence, the results of this research will generate a model that can form a basis for scheduling the dredging event prior to the placement of off-shore cast shells replacing the current as and when required approach of dredging plan. 1 Graduate Student, Department of Civil Engineering, Southern Illinois University Carbondale Carbondale, Illinois, 62901-6603 2 Professor, Department of Civil Engineering, Southern Illinois University Carbondale Carbondale, Illinois, 62901-6603

Assessment of the Potential of CDK2 Inhibitor NU6140 to Influence the Expression of Pluripotency Markers NANOG, OCT4, and SOX2 in 2102Ep and H9 Cells

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Ade Kallas

2014-01-01

Full Text Available As cyclin-dependent kinases (CDKs regulate cell cycle progression and RNA transcription, CDKs are attractive targets for creating cancer cell treatments. In this study we investigated the effects of the small molecular agent NU6140 (inhibits CDK2 and cyclin A interaction on human embryonic stem (hES cells and embryonal carcinoma-derived (hEC cells via the expression of transcription factors responsible for pluripotency. A multiparameter flow cytometric method was used to follow changes in the expression of NANOG, OCT4, and SOX2 together in single cells. Both hES and hEC cells responded to NU6140 treatment by induced apoptosis and a decreased expression of NANOG, OCT4, and SOX2 in surviving cells. A higher sensitivity to NU6140 application in hES than hEC cells was detected. NU6140 treatment arrested hES and hEC cells in the G2 phase and inhibited entry into the M phase as evidenced by no significant increase in histone 3 phosphorylation. When embryoid bodies (EBs formed from NU6104 treated hES cells were compared to EBs from untreated hES cells differences in ectodermal, endodermal, and mesodermal lineages were found. The results of this study highlight the importance of CDK2 activity in maintaining pluripotency of hES and hEC cells and in differentiation of hES cells.

Measurement of emotional contagion using synchronization of heart rhythm pattern between two persons: Application to sales managers and sales force synchronization.

Science.gov (United States)

Park, Sangin; Choi, Soo Ji; Mun, Sungchul; Whang, Mincheol

2018-04-19

The purpose of this study was to measure emotional contagion, determine its direction, and compare the intensity between positive and negative contagion using the synchronization of heart rhythm pattern (HRP). A total of 64 undergraduate students (32 women and 32 men) participated in the experiment, and were randomly categorized as either leaders or followers. Followers were required to imitate the facial expression (happy and sad) of the leader (emotional contagion) or of a facial image (emotional non-contagion). We found that emotional contagion significantly increased the correlation coefficient between leaders and followers' HRP for both positive and negative emotions, but emotional non-contagion did not. There was no significant difference in leaders' HRP before and after contagion, while followers' HRP changed significantly. During emotional contagion, the correlation coefficient for negative emotion was significantly higher than for positive emotion. The proposed method could measure low or high emotional contagion and determine its direction quantitatively. In our application study, a sales manager (leader) transmitted a positive emotion to a sales employee (follower), and the groups are organized as HEC or LEC (high or low emotional contagion) groups by evaluating the intensity of emotional contagion based on HRP synchrony between them. HEC group's performance was enhanced compared to the LEC group. Copyright © 2018. Published by Elsevier Inc.

Global Positioning System Derived Performance Measures Are Responsive Indicators of Physical Activity, Disease and the Success of Clinical Treatments in Domestic Dogs

Science.gov (United States)

Bruno, Elizabeth A.; Guthrie, James W.; Ellwood, Stephen A.; Mellanby, Richard J.; Clements, Dylan N.

2015-01-01

Objective To assess the use of Global Positioning System receiver (GPS) derived performance measures for differentiating between: 1) different outdoor activities in healthy dogs; 2) healthy dogs and those with osteoarthritis; 3) osteoarthritic dogs before and after treatment with non-steroidal anti-inflammatory analgesia. Design Prospective study. Animals Ten healthy dogs and seven dogs with osteoarthritis of the elbow joint (OA dogs). Procedure Healthy dogs were walked on a standard route on-lead, off-lead and subjected to playing activity (chasing a ball) whilst wearing a GPS collar. Each dog was walked for five consecutive days. Dogs with OA were subjected to a single off-lead walk whilst wearing a GPS collar, and then administered oral Carprofen analgesia daily for two weeks. OA dogs were then subjected to the same walk, again wearing a GPS collar. Results GPS derived measures of physical performance could differentiate between on-lead activity, off-lead activity and playing activity in healthy dogs, and between healthy dogs and OA dogs. Variation in the performance measures analysed was greater between individual dogs than for individual dogs on different days. Performance measures could differentiate healthy dogs from OA dogs. OA Dogs treated with Carprofen analgesia showed improvements in their physical performance, which returned to values indistinguishable from those of healthy dogs on nearly all the measures assessed. Conclusions and Clinical Relevance GPS derived measures of physical performance in dogs are objective, easy to quantify, and can be used to gauge the effects of disease and success of clinical treatments. Specific stimuli can be used to modulate physical performance beyond the self-governed boundaries that dogs will naturally express when allowed to exercise freely without stimulation. PMID:25692761

Analysis and Application of River Surface Line in Hilly Area based on Hec-ras Model

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Yang Congshan

2017-01-01

Full Text Available For example—Cixian Fuyang River Regulation Project. Due to the character that Fuyang River is located in hilly areas of Cixian, we use the Hex-ras software to calculate the status of the river water surface line for the goal of determining the final treatment plan. We maintain the present situation of the river channel design as principle, select the most appropriate pushed water level and roughnessas the basic, and we combine the classification calculation of crossing structures of backwater and the encryption calculation section to get the more accurate result. We compare the water level elevation and the calculation of cross strait, analyze the design parameters, calculate repeated the water line section, analyze the rationality of the design plan, and then finally determine the applicability of Hex-rac software in the large continuous variation of cross section of embankment of river river surface line.

New configuration for efficient and durable copper coating on the outer surface of a tube

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Irfan Ahmad

2017-03-01

Full Text Available A well-adhered copper coating on stainless steel power coupler parts is required in superconducting radio frequency (SRF accelerators. Radio frequency power coupler parts are complex, tubelike stainless steel structures, which require copper coating on their outer and inner surfaces. Conventional copper electroplating sometimes produces films with inadequate adhesion strength for SRF applications. Electroplating also requires a thin nickel strike layer under the copper coating, whose magnetic properties can be detrimental to SRF applications. Coaxial energetic deposition (CED and sputtering methods have demonstrated efficient conformal coating on the inner surfaces of tubes but coating the outer surface of a tube is challenging because these coating methods are line of sight. When the substrate is off axis and the plasma source is on axis, only a small section of the substrate’s outer surface is exposed to the source cathode. The conventional approach is to rotate the tube to achieve uniformity across the outer surface. This method results in poor film thickness uniformity and wastes most of the source plasma. Alameda Applied Sciences Corporation (AASC has developed a novel configuration called hollow external cathode CED (HEC-CED to overcome these issues. HEC-CED produces a film with uniform thickness and efficiently uses all eroded source material. The Cu film deposited on the outside of a stainless steel tube using the new HEC-CED configuration survived a high pressure water rinse adhesion test. HEC-CED can be used to coat the outside of any cylindrical structure.

Synthesis and Features of Luminescent Bromo- and Iodohectorite Nanoclay Materials

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Hellen Silva Santos

2017-11-01

Full Text Available The smectites represent a versatile class of clay minerals with broad usage in industrial applications, e.g., cosmetics, drug delivery, bioimaging, etc. Synthetic hectorite Na0.7(Mg5.5Li0.3[Si8O20](OH4 is a distinct material from this class due to its low-cost production method that allows to design its structure to match better the applications. In the current work, we have synthesized for the first time ever nanoclay materials based on the hectorite structure but with the hydroxyl groups (OH− replaced by Br− or I−, yielding bromohectorite (Br-Hec and iodohectorite (I-Hec. It was aimed that these materials would be used as phosphors. Thus, OH− replacement was done to avoid luminescence quenching by multiphonon de-excitation. The crystal structure is similar to nanocrystalline fluorohectorite, having the d001 spacing of 14.30 Å and 3 nm crystallite size along the 00l direction. The synthetic materials studied here show strong potential to act as host lattices for optically active species, possessing mesoporous structure with high specific surface area (385 and 363 m2 g−1 for Br-Hec and I-Hec, respectively and good thermal stability up to 800 °C. Both materials also present strong blue-green emission under UV radiation and short persistent luminescence (ca. 5 s. The luminescence features are attributed to Ti3+/TiIV impurities acting as the emitting center in these materials.

MODELLING THE IMPACTS OF WILDFIRE ON SURFACE RUNOFF IN THE UPPER UBERABINHA RIVER WATERSHED USING HEC-HMS

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Jean Maikon Santos Oliveira

2017-01-01

Full Text Available Fire significantly affects hydrological processes in the waters hed because it changes land cover and it creates a double layer of hydrophobic soil co vered with ash, increasing the surface runoff and the production of debris flow in the basin. Assessing the impacts of fire on overland flow requires the use of modeli ng softwares capable of simulating post-fire discharge. Because a total of 760 wildfire s were detected in the Upper Uberabinha River subbasin in the last nine years, it is o f dire importance to understand the consequential impacts of fire on hydrological pr ocesses in this basin. In this study, the HEC-HMS model was used to evaluate post-fire di scharge in the Upper Uberabinha River watershed. Model was previously calibrated and validated using two representative storms observed in the wet season. After calibra tion, the 5-, 10-, 25-, 50-, 100-, and 200-year storms were simulated in scenarios with incr easing burn severity. The calibrated model performed well in the prediction of discha rge values at a daily basis (0% difference in peak tim ing; 0% difference in peak flow ; 31.8% BIAS . Peak flow and discharge volume increased and peak timing shifted to the left as severity of burn increased. The highest increment in peak discharge was 74. 7% for the 10-year storm, whereas overall discharge volume raised in up to 31.9% f or the 50-year storm, both after simulation in the mos t fire-impacted scenario. The results reveal that fire highly affects hydrological characteristics, e.g. peak timing a nd flow and discharge volume, in the Upper Uberabinha River watershed. The authors su ggest further investigations concerning the impacts of wildfire on other proc esses, such as the production of debris flow in the basin.

Oil-in-Water Emulsions Stabilized by Saponified Epoxidized Soybean Oil-Grafted Hydroxyethyl Cellulose.

Science.gov (United States)

Huang, Xujuan; Li, Qiaoguang; Liu, He; Shang, Shibin; Shen, Minggui; Song, Jie

2017-05-03

An oil-in-water emulsion stabilized by saponified epoxidized soybean oil-grafted hydroxyethyl cellulose (H-ESO-HEC) was investigated. By using an ultrasonic method, oil-in-water emulsions were prepared by blending 50 wt % soybean oil and 50 wt % H-ESO-HEC aqueous suspensions. The influence of H-ESO-HEC concentrations on the properties of oil-in-water emulsions was examined. The H-ESO-HEC concentrations in the aqueous phase varied from 0.02 to 0.40 wt %. When the H-ESO-HEC concentration was 0.4 wt %, the emulsion remained stable for >80 days. The mean droplet sizes of the emulsions decreased by increasing the H-ESO-HEC concentration and extending the ultrasonic time. The adsorption amounts of H-ESO-HEC at the oil-water interface increased when the H-ESO-HEC concentrations in the aqueous phase increased. The rheological property revealed that the apparent viscosity of the H-ESO-HEC-stabilized oil-in-water emulsions increased when the H-ESO-HEC concentrations increased. Steady flow curves indicated an interfacial film formation in the emulsions. The evolution of G', G″, and tan η indicated the predominantly elastic behaviors of all the emulsions.

CRITICAL ISSUES IN HIGH END COMPUTING - FINAL REPORT

Energy Technology Data Exchange (ETDEWEB)

Corones, James [Krell Institute

2013-09-23

High-End computing (HEC) has been a driver for advances in science and engineering for the past four decades. Increasingly HEC has become a significant element in the national security, economic vitality, and competitiveness of the United States. Advances in HEC provide results that cut across traditional disciplinary and organizational boundaries. This program provides opportunities to share information about HEC systems and computational techniques across multiple disciplines and organizations through conferences and exhibitions of HEC advances held in Washington DC so that mission agency staff, scientists, and industry can come together with White House, Congressional and Legislative staff in an environment conducive to the sharing of technical information, accomplishments, goals, and plans. A common thread across this series of conferences is the understanding of computational science and applied mathematics techniques across a diverse set of application areas of interest to the Nation. The specific objectives of this program are: Program Objective 1. To provide opportunities to share information about advances in high-end computing systems and computational techniques between mission critical agencies, agency laboratories, academics, and industry. Program Objective 2. To gather pertinent data, address specific topics of wide interest to mission critical agencies. Program Objective 3. To promote a continuing discussion of critical issues in high-end computing. Program Objective 4.To provide a venue where a multidisciplinary scientific audience can discuss the difficulties applying computational science techniques to specific problems and can specify future research that, if successful, will eliminate these problems.

Opening the black box of ethics policy work: evaluating a covert practice.

Science.gov (United States)

Frolic, Andrea; Drolet, Katherine; Bryanton, Kim; Caron, Carole; Cupido, Cynthia; Flaherty, Barb; Fung, Sylvia; McCall, Lori

2012-01-01

Hospital ethics committees (HECs) and ethicists generally describe themselves as engaged in four domains of practice: case consultation, research, education, and policy work. Despite the increasing attention to quality indicators, practice standards, and evaluation methods for the other domains, comparatively little is known or published about the policy work of HECs or ethicists. This article attempts to open the "black box" of this health care ethics practice by providing two detailed case examples of ethics policy reviews. We also describe the development and application of an evaluation strategy to assess the quality of ethics policy review work, and to enable continuous improvement of ethics policy review processes. Given the potential for policy work to impact entire patient populations and organizational systems, it is imperative that HECs and ethicists develop clearer roles, responsibilities, procedural standards, and evaluation methods to ensure the delivery of consistent, relevant, and high-quality ethics policy reviews.

Flood risk assessment through 1D/2D couple HEC-RAS hydrodynamic modeling- A case study of Surat City, Lower Tapi Basin, India

Science.gov (United States)

Patel, Dhruvesh; Ramirez, Jorge; Srivastava, Prashant; Bray, Michaela; Han, Dawei

2017-04-01

Surat, known as the diamond city of Gujart is situated 100 km downstream of Ukai dam and near the mouth of river Tapi and affected by the flood at every alternate year. The city experienced catastrophic floods in 1933, 1959, 1968, 1970, 1994, 1998 and 2006. It is estimated that a single flood event during August 6-12, 2006 in Surat and Hazira twin-city, caused heavy damages, resulted in the death of 300 people and property damage worth € 289 million. The peak discharge of 25768 m3 s-1 release from Ukai dam was responsible for the disastrous flood in Surat city. To identifylow lying areas prone to inundation and reduce the uncertainty in flood mitigation measures, HEC-RAS based 1D/2D Couple hydrodynamic modeling is carried out for Surat city. Release from the Ukai dam and tidal level of the sea are considered for upstream and downstream boundary condition. 299 surveyed cross-sections have been considered for 1D modeling, whereas a topographic map at 0.5 m contour interval was used to produce a 5 m grid and SRTM (30 & 90 m) grid has been considered for Suart and Lower Tapi Basin (LTB). Flow is simulated under unsteady conditions, calibrated for the year 1998 and validated for the year 2006. The simulated result shows that the 9th August 18.00 hr was the worst day for Surat city and maximum 75-77 % area was under inundation. Most of the flooded area experienced 0.25 m/s water velocity with the duration of 90 hr. Due to low velocity and high duration of the flood, a low lying area within the west zone and south-west zone of the city was badly affected by the flood, whereas the south zone and south-east zone was least. Simulated results show good correlation when compared with an observed flood level map. The simulated results will be helpful to improve the flood resilience strategy at Surat city and reduce the uncertainty for flood inundation mapping for future dam releases. The present case study shows the applicability of 1D/2D coupled hydrodynamic modeling for

Organiser l'accès électronique à des périodiques : Analyse des outils et proposition pour la mise en place d'une solution d'accès à la bibliothèque d'HEC

OpenAIRE

Boutin, Christine

2007-01-01

Ce mémoire est centré sur l'organisation de l'accès aux périodiques et l'offre du marché dans ce domaine. Pour circonscrire l'ensemble de la problématique, les différentes offres de périodiques, les besoins en accès des utilisateurs et les contraintes posées par les modalités d'accès sont définis. Sont alors présentés quelques produits ayant vocation à l'unification de l'accès aux périodiques. Puis une évaluation de ces outils est menée à partir du cas de la bibliothèque d'HEC : elle est l'oc...

Randomized phase III trial of APF530 versus palonosetron in the prevention of chemotherapy-induced nausea and vomiting in a subset of patients with breast cancer receiving moderately or highly emetogenic chemotherapy

International Nuclear Information System (INIS)

Boccia, Ralph; O’Boyle, Erin; Cooper, William

2016-01-01

APF530 provides controlled, sustained-release granisetron for preventing acute (0–24 h) and delayed (24–120 h) chemotherapy-induced nausea and vomiting (CINV). In a phase III trial, APF530 was noninferior to palonosetron in preventing acute CINV following single-dose moderately (MEC) or highly emetogenic chemotherapy (HEC) and delayed CINV in MEC (MEC and HEC defined by Hesketh criteria). This exploratory subanalysis was conducted in the breast cancer subpopulation. Patients were randomized to subcutaneous APF530 250 or 500 mg (granisetron 5 or 10 mg) or intravenous palonosetron 0.25 mg during cycle 1. Palonosetron patients were randomized to APF530 for cycles 2 to 4. The primary efficacy end point was complete response (CR, no emesis or rescue medication) in cycle 1. Among breast cancer patients (n = 423 MEC, n = 185 HEC), > 70 % received anthracycline-containing regimens in each emetogenicity subgroup. There were no significant between-group differences in CRs in cycle 1 for acute (APF530 250 mg: MEC 71 %, HEC 77 %; 500 mg: MEC 73 %, HEC 73 %; palonosetron: MEC 68 %, HEC 66 %) and delayed (APF530 250 mg: MEC 46 %, HEC 58 %; 500 mg: MEC 48 %, HEC 63 %; palonosetron: MEC 52 %, HEC 52 %) CINV. There were no significant differences in within-cycle CRs between APF530 doses for acute and delayed CINV in MEC or HEC in cycles 2 to 4; CRs trended higher in later cycles, with no notable differences in adverse events between breast cancer and overall populations. APF530 effectively prevented acute and delayed CINV over 4 chemotherapy cycles in breast cancer patients receiving MEC or HEC. Clinicaltrials.gov identifier: NCT00343460 (June 22, 2006)

Kankakee River Basin: Evaluation of Sediment Management Strategies

Science.gov (United States)

2013-09-01

basin, and development of a SIAM model from an existing US Army Corps of Engineers Hydrologic Engineering Center, River Analysis System ( HEC - RAS ...4 SIAM Model A SIAM model was developed from an existing calibrated HEC - RAS model provided by the Rock Island District. The limits of the HEC - RAS ...model are shown in Figure 4.1. No further effort was made to verify the calibration of the HEC - RAS model. The estimated sediment loads were used to

Minnehaha Creek Watershed SWMM5 Model Data Analysis and Future Recommendations

Science.gov (United States)

2013-07-01

Water Bodies Organization 1 SWMM5 LMCW EPA 1 HEC - RAS Minnehaha Creek and Lake Minnetonka system HEC 2 CE-QUAL-W2 Lake Minnetonka system ERDC...and adjusted as needed to adequately address project goals and priorities. SWMM5 and HEC - RAS are the recommended Tier 1 models. The current SWMM5...model is an appropriate modeling platform for modeling subbasins in the LMCW. HEC - RAS should be used to model Minnehaha Creek and the Lake Minnetonka

Preparation of novel stable antibacterial nanoparticles using hydroxyethylcellulose and application in paper.

Science.gov (United States)

Wei, Dafu; Chen, Yan; Zhang, Youwei

2016-01-20

Taking advantage of the self-assembly between the components, novel stable antibacterial nanoparticles were efficiently fabricated via a facile one-step co-polymerization of acrylic acid (AA) and N,N'-methylenebisacrylamide (MBA) on a mixed aqueous solution of poly(hexamethylene guanidine hydrochloride) (PHMG) and hydroxyethylcellulose (HEC). The z-average hydrodynamic diameters of the nanoparticles ranged from 220 nm to 450 nm. The inner layer of the nanoparticles is composed of water-insoluble interpolymer complexes of PHMG and PAA networks, while the outer layer is composed of PHMG and HEC. The nanoparticles are stabilized by electrostatic interactions, hydrogen bonding interactions, and the chemical bonds. The nanoparticle solution remained stable in a wide pH range of 2.0-12.0 and at salt concentrations below 0.25 mol/L. The nanoparticles were incorporated into handsheets using a dipping treatment. The resulted handsheets exhibited excellent antimicrobial activities even after multiple water washing treatments. The nanoparticles are promising in fabricating paper, water-based coatings and textiles with permanent antibacterial activity. Copyright © 2015 Elsevier Ltd. All rights reserved.

Review Plan Using the NWD Model Review Plan for Continuing Authorities Program Section 14, 107, 111, 204, 206, 208, 1135 and Projects Directed by Guidance to Use CAP Procedures: Sheridan, Wyoming, Section 1135 Project

Science.gov (United States)

2014-12-19

Approval Status HEC - RAS 4.1 HEC - RAS is designed to perform one-dimensional hydraulic calculations for a full network of natural and constructed...channels. The HEC - RAS system contains four one-dimensional river analysis components for: (1) steady flow water surface profile computations; (2

Health-e-Child a grid platform for european paediatrics

CERN Document Server

Skaburskas, K; Shade, J; Manset, D; Revillard, J; Rios, A; Anjum, A; Branson, A; Bloodsworth, P; Hauer, T; McClatchey, R; Rogulin, D

2008-01-01

The Health-e-Child (HeC) project [1], [2] is an EC Framework Programme 6 Integrated Project that aims to develop a grid-based integrated healthcare platform for paediatrics. Using this platform biomedical informaticians will integrate heterogeneous data and perform epidemiological studies across Europe. The resulting Grid enabled biomedical information platform will be supported by robust search, optimization and matching techniques for information collected in hospitals across Europe. In particular, paediatricians will be provided with decision support, knowledge discovery and disease modelling applications that will access data in hospitals in the UK, Italy and France, integrated via the Grid. For economy of scale, reusability, extensibility, and maintainability, HeC is being developed on top of an EGEE/gLite [3] based infrastructure that provides all the common data and computation management services required by the applications. This paper discusses some of the major challenges in bio-medical data integr...

Determination of Heavy Metal Concentrations in Normal and Pathological Human Endometrial Biopsies and In Vitro Regulation of Gene Expression by Metals in the Ishikawa and Hec-1b Endometrial Cell Line.

Directory of Open Access Journals (Sweden)

Erwan Guyot

Full Text Available It is well known that several metals, such as lead, mercury, cadmium, and vanadium, can mimic the effects of estrogens (metallo-estrogens. Nevertheless, there are only a few studies that have assessed the effects of toxic metals on the female genital tract and, in particular, endometrial tissue. In this context, we measured the concentrations of several trace elements in human endometrial tissue samples from individuals with hyperplasia or adenocarcinoma and in normal tissues. Hyperplasic endometrial tissue has a 4-fold higher concentration of mercury than normal tissue. Mercury can affect both the AhR and ROS signaling pathways. Thus, we investigated the possible toxic effects of mercury by in vitro studies. We found that mercury increases oxidative stress (increased HO1 and NQO1 mRNA levels and alters the cytoskeleton in the human endometrial Ishikawa cell line and to a lesser extent, in the "less-differentiated" human endometrial Hec-1b cells. The results might help to explain a potential link between this metal and the occurrence of endometrial hyperplasia.

Determination of Heavy Metal Concentrations in Normal and Pathological Human Endometrial Biopsies and In Vitro Regulation of Gene Expression by Metals in the Ishikawa and Hec-1b Endometrial Cell Line

Science.gov (United States)

Tomkiewicz, Céline; Leblanc, Alix; Pierre, Stéphane; El Balkhi, Souleiman; Le Frère-Belda, Marie-Aude; Lecuru, Fabrice; Poupon, Joël; Barouki, Robert; Aggerbeck, Martine; Coumoul, Xavier

2015-01-01

It is well known that several metals, such as lead, mercury, cadmium, and vanadium, can mimic the effects of estrogens (metallo-estrogens). Nevertheless, there are only a few studies that have assessed the effects of toxic metals on the female genital tract and, in particular, endometrial tissue. In this context, we measured the concentrations of several trace elements in human endometrial tissue samples from individuals with hyperplasia or adenocarcinoma and in normal tissues. Hyperplasic endometrial tissue has a 4-fold higher concentration of mercury than normal tissue. Mercury can affect both the AhR and ROS signaling pathways. Thus, we investigated the possible toxic effects of mercury by in vitro studies. We found that mercury increases oxidative stress (increased HO1 and NQO1 mRNA levels) and alters the cytoskeleton in the human endometrial Ishikawa cell line and to a lesser extent, in the “less-differentiated” human endometrial Hec-1b cells. The results might help to explain a potential link between this metal and the occurrence of endometrial hyperplasia. PMID:26600472

Situk River Hydrology Following Closure of Russell Fiord by Hubbard Glacier

Science.gov (United States)

2011-03-01

approximately 137.2 ft. A HEC - RAS one-dimensional flow model estimated the levels and flows of the Si- tuk River system, including the Old Situk, Upper...23 Development of HEC - RAS geometry for Situk River ................................................................. 26 Boundary conditions...28 Figure 20. Situk River geometry model in HEC - RAS

Surface-modified anodic aluminum oxide membrane with hydroxyethyl celluloses as a matrix for bilirubin removal.

Science.gov (United States)

Xue, Maoqiang; Ling, Yisheng; Wu, Guisen; Liu, Xin; Ge, Dongtao; Shi, Wei

2013-01-01

Microporous anodic aluminum oxide (AAO) membranes were modified by 3-glycidoxypropyltrimethoxysilane to produce terminal epoxy groups. These were used to covalently link hydroxyethyl celluloses (HEC) to amplify reactive groups of AAO membrane. The hydroxyl groups of HEC-AAO composite membrane were further modified with 1,4-butanediol diglycidyl ether to link arginine as an affinity ligand. The contents of HEC and arginine of arginine-immobilized HEC-AAO membrane were 52.1 and 19.7mg/g membrane, respectively. As biomedical adsorbents, the arginine-immobilized HEC-AAO membranes were tested for bilirubin removal. The non-specific bilirubin adsorption on the unmodified HEC-AAO composite membranes was 0.8mg/g membrane. Higher bilirubin adsorption values, up to 52.6mg/g membrane, were obtained with the arginine-immobilized HEC-AAO membranes. Elution of bilirubin showed desorption ratio was up to 85% using 0.3M NaSCN solution as the desorption agent. Comparisons equilibrium and dynamic capacities showed that dynamic capacities were lower than the equilibrium capacities. In addition, the adsorption mechanism of bilirubin and the effects of temperature, initial concentration of bilirubin, albumin concentration and ionic strength on adsorption were also investigated. Copyright © 2012 Elsevier B.V. All rights reserved.

Hydroxyethyl cellulose hydrogel for wound dressing: Fabrication, characterization and in vitro evaluation.

Science.gov (United States)

El Fawal, Gomaa F; Abu-Serie, Marwa M; Hassan, Mohamed A; Elnouby, Mohamed S

2018-05-01

In this study, new hydrogel membranes were developed based on hydroxyethyl cellulose (HEC) supplemented with tungsten oxide for further implementing in wound treatment. HEC hydrogel membranes were fabricated and crosslinked using citric acid (CA). Various tests were carried out including FTIR, XRD, porosity measurements, swelling, mechanical properties, gel fraction, and thermal gravimetric analysis to evaluate the efficiency of the prepared membranes as wound dressing material. In addition, wound healing activity of the examined membranes for human dermal fibroblast cell line was investigated employing in vitro scratching model. Furthermore, the potency of the prepared membranes to suppress wound complications was studied via determination of their anti-inflammatory and antibacterial activities exploiting MTT, ELISA, and disk agar diffusion methods. The results demonstrated that the HEC hydrogel membranes revealed an anti-inflammatory and antibacterial efficacy. Moreover, HEC improved the safety of tungsten oxide toward normal human cells (white blood cells and dermal fibroblast). Furthermore, HEC membranes loaded with WO 3 revealed the highest activities against Salmonella sp. pursued by P. aeruginosa in compared with the negative HEC hydrogel membrane. The current approach corroborated that HEC amended by tungsten oxide could be applied as a promising safe candidate for wound dressing material. Copyright © 2018 Elsevier B.V. All rights reserved.

Progress in LAr EndCap Calorimetry: News from the Hadronic EndCap Group.

CERN Multimedia

Oram, C.J.

With module production and testing completed for the Hadronic EndCap calorimeter, the attention of the HEC group is heavily directed towards wheel assembly in building 180. Three of the four HEC wheels are now assembled and rotated, and work is progressing on assembling the final wheel. This year has been a busy year for the installation of components in the EndCap C cryostat: the signal feedthrough installation was completed April 22nd, the pre-sampler shortly thereafter and the Electro-Magnetic EndCap August 13th. This allowed the HEC group to start transferring the HEC wheels from the T6A storage cradle into the cryostat. The operation started in mid-September and has progressed, on or ahead of schedule, since then with the major milestones being: Insertion of 67 ton front HEC wheel October 3rd Insertion of 90 ton rear HEC wheel October 22nd. The wheel alignment has proved to be excellent, with the position of the centre of the front(rear) wheel with respect to the nominal position being displaced b...

Home-Made Money: Consumer's Guide to Home Equity Conversion.

Science.gov (United States)

Scholen, Ken

This guide was written to introduce consumers to home equity conversion (HEC) plans that are currently available and to explain the current state of HEC developments. It describes how the basic types of HEC plans work, gives examples of how how they can be used, discusses their advantages and disadvantages, and tells where they are available.…

The Evolution of American Hospital Ethics Committees: A Systematic Review.

Science.gov (United States)

Courtwright, Andrew; Jurchak, Martha

2016-01-01

During the 1970s and 1980s, legal precedent, governmental recommendations, and professional society guidelines drove the formation of hospital ethics committees (HECs). The Joint Commission on Accreditation of Health Care Organization's requirements in the early 1990s solidified the role of HECs as the primary mechanism to address ethical issues in patient care. Because external factors drove the rapid growth of HECs on an institution-by-institution basis, however, no initial consensus formed around the structure and function of these committees. There are now almost 40 years of empirical studies on the composition, administration, and activities of HECs in the United States. We conducted a systematic review of the available empirical literature on HECs to describe their evolution. As HECs changed over time, they increased their total number of members and percentage of members from nursing and the community. Although physicians increasingly chaired these committees, their presence as a percentage of overall members declined. The percentage of administrative members remained steady, although committees became increasingly likely to have at least one administrative member. HECs were also increasingly likely to report to an administrative body or to the board of trustees or directors rather than to the medical staff. Finally, consultation volume increased steadily over time. There has not, however, been a national survey of the composition of ethics committees, their administration, or volume of consultation in more than 10 years, despite increasing calls for professional standards and quality improvement assessments among HECs. Copyright 2016 The Journal of Clinical Ethics. All rights reserved.

Buried waste integrated demonstration human engineered control station. Final report

Energy Technology Data Exchange (ETDEWEB)

1994-09-01

This document describes the Human Engineered Control Station (HECS) project activities including the conceptual designs. The purpose of the HECS is to enhance the effectiveness and efficiency of remote retrieval by providing an integrated remote control station. The HECS integrates human capabilities, limitations, and expectations into the design to reduce the potential for human error, provides an easy system to learn and operate, provides an increased productivity, and reduces the ultimate investment in training. The overall HECS consists of the technology interface stations, supporting engineering aids, platform (trailer), communications network (broadband system), and collision avoidance system.

Buried waste integrated demonstration human engineered control station. Final report

International Nuclear Information System (INIS)

1994-09-01

This document describes the Human Engineered Control Station (HECS) project activities including the conceptual designs. The purpose of the HECS is to enhance the effectiveness and efficiency of remote retrieval by providing an integrated remote control station. The HECS integrates human capabilities, limitations, and expectations into the design to reduce the potential for human error, provides an easy system to learn and operate, provides an increased productivity, and reduces the ultimate investment in training. The overall HECS consists of the technology interface stations, supporting engineering aids, platform (trailer), communications network (broadband system), and collision avoidance system

Integration of contributed data with HEC-RAS hydrodynamic model for flood inundation and damage assessment: 2015 Dallas Texas Case Study

Science.gov (United States)

Sava, E.; Thornton, J. C.; Kalyanapu, A. J.; Cervone, G.

2016-12-01

Transportation infrastructure networks in urban areas are highly sensitive to natural disasters, yet are a very critical source for the success of rescue, recovery, and renovation operations. Therefore, prompt restoration of such networks is of high importance for disaster relief services. Satellite and aerial images provide data with high spatial and temporal resolution and are a powerful tool for monitoring the environment and mapping the spatio-temporal variability of the Earth's surface. They provide a synoptic overview and give useful environmental information for a wide range of scales, from entire continents to urban areas, with spatial pixel resolutions ranging from kilometers to centimeters. However, sensor limitations are often a serious drawback since no single sensor offers the optimal spectral, spatial, and temporal resolution at the same time. Specific data may not be collected in the time and space most urgently required and/or may it contain gaps as a result of the satellite revisit time, atmospheric opacity, or other obstructions. In this study, the feasibility of integrating multiple sources of contributed data including remotely sensed datasets and open-source geospatial datasets, into hydrodynamic models for flood inundation simulations is assessed. The 2015 Dallas floods that caused up to $61 million dollars in damage was selected for this study. A Hydraulic Engineering Center - River Analysis System (HEC-RAS) model was developed for the study area, using reservoir surcharge releases and geometry provided by the U.S. Army Corps of Engineers Fort Worth District. The simulated flood inundation is compared with the "contributed data" for the location (such as Civil Air Patrol data and WorldView 3 dataset) which indicated the model's lack of representing lateral inflows near the upstream section. An Artificial Neural Network (ANN) model is developed that used local precipitation and discharge values in the vicinity to estimate the lateral flows

2D Hydrodynamic Investigation of Olmsted Cofferdams

Science.gov (United States)

2013-07-01

34  Figure 30. HEC - RAS cross-section locations in the AdH 2012. ........................................................... 34...stress in Pascals for Condition 1 (typical). ........................................................ 40  Figure 43. HEC - RAS cross-section locations in...Then in 2008, CHL used an Adaptive Hydraulics model (AdH) to further evaluate potential impacts on mussel beds. In 2012, LRL used a HEC - RAS model to

Mount St. Helens Future Expected Deposition Scenario (FEDS)

Science.gov (United States)

2011-04-14

sediment plain for the period from 2008 to 2035 is estimated to be 215 M Tons. Sediment transport models using both 1-D HEC - RAS and 2-D MIKE 21C... HEC - RAS software. This mobile-bed tool was developed from a hydraulically-calibrated fixed- bed model utilized in the 2009 Level of Protection...38 3.2 1-D HEC - RAS Model .............................................................................................38 3.2.1 Model

Design of cellulose ether-based macromolecular prodrugs of ciprofloxacin for extended release and enhanced bioavailability.

Science.gov (United States)

Amin, Muhammad; Abbas, Nazia Shahana; Hussain, Muhammad Ajaz; Sher, Muhammad; Edgar, Kevin J

2018-07-01

The present study reveals the syntheses of hydroxypropylcellulose‑(HPC) and hydroxyethylcellulose‑(HEC) based macromolecular prodrugs (MPDs) of ciprofloxacin (CIP) using homogeneous reaction methodology. Covalently loaded drug content (DC) of each prodrug was quantified using UV-Vis spectrophotometry to determine degree of substitution (DS). HPC-ciprofloxacin (HPC-CIP) conjugates showed DS of CIP in the range 0.87-1.15 whereas HEC-ciprofloxacin (HEC-CIP) conjugates showed DS range 0.51-0.75. Transmission electron microscopy revealed that HPC-CIP conjugate 2 and HEC-CIP conjugate 6 self-assembled into nanoparticles of 150-300 and 180-250nm, respectively. Size exclusion chromatography revealed HPC-CIP conjugate 2 and HEC-CIP conjugate 6 as monodisperse systems. In vitro drug release studies indicated 15 and 43% CIP release from HPC-CIP conjugate 2 after 6h in simulated gastric and simulated intestinal fluids (SGF and SIF), respectively. HEC-CIP conjugate 6 showed 16% and 46% release after 6h in SGF and SIF, respectively. HPC-CIP conjugate 2 and HEC-CIP conjugate 6 exhibited half-lives of 10.87 and 11.71h, respectively with area under the curve values of 164 and 175hμgmL -1 , respectively, indicating enhanced bioavailability and improved pharmacokinetic profiles in animal model. Equal antibacterial activities to that of unmodified CIP confirmed their competitive efficacies. Cytotoxicity studies supported their non-toxic nature and biocompatibility. Copyright © 2018 Elsevier B.V. All rights reserved.

Demonstration of an in situ morphing hyperelliptical cambered span wing mechanism

International Nuclear Information System (INIS)

Manzo, Justin; Garcia, Ephrahim

2010-01-01

Research on efficient shore bird morphology inspired the hyperelliptical cambered span (HECS) wing, a crescent-shaped, aft-swept wing with vertically oriented wingtips. The wing reduces vorticity-induced circulation loss and outperforms an elliptical baseline when planar. Designed initially as a rigid wing, the HECS wing makes use of morphing to transition from a planar to a furled configuration, similar to that of a continuously curved winglet, in flight. A morphing wing concept mechanism is presented, employing shape memory alloy actuators to create a discretized curvature approximation. The aerodynamics for continuous wing shapes is validated quasi-statically through wind tunnel testing, showing enhanced planar HECS wing lift-to-drag performance over an elliptical wing, with the furled HECS wing showing minimal enhancements beyond this point. Wind tunnel tests of the active morphing wing prove the mechanism capable of overcoming realistic loading, while further testing may be required to establish aerodynamic merits of the HECS wing morphing maneuver

Informal Workshop on Burial and Mobility Modeling of Munitions in the Underwater Environment

Science.gov (United States)

2014-12-01

Engineers (USACE) funding (e.g., HEC - RAS – http://www.hec.usace.army.mil/software/ hec - ras /). 4.3. Near Field Versus Far Field Near field...Naval Research PI – Principal Investigator PMRF – Pacific Missile Range Facility RAS – Risk Assessment System RI – Remedial Investigation SERDP...concept for the prototype Risk Assessment System ( RAS ) links output from a probabilistic SERDP REPORT – INFORMAL WORKSHOP ON BURIAL AND MOBILITY

Comparison of an extended-release formulation of granisetron (APF530) versus palonosetron for the prevention of chemotherapy-induced nausea and vomiting associated with moderately or highly emetogenic chemotherapy: results of a prospective, randomized, double-blind, noninferiority phase 3 trial.

Science.gov (United States)

Raftopoulos, Harry; Cooper, William; O'Boyle, Erin; Gabrail, Nashat; Boccia, Ralph; Gralla, Richard J

2015-03-01

Subcutaneous APF530 provides controlled sustained release of granisetron to prevent acute (0-24 h) and delayed (24-120 h) chemotherapy-induced nausea and vomiting (CINV). This randomized, double-blind phase 3 trial compared APF530 and palonosetron in preventing acute and delayed CINV after moderately (MEC) or highly emetogenic chemotherapy (HEC). Patients receiving single-day MEC or HEC received single-dose APF530 250 or 500 mg subcutaneously (SC) (granisetron 5 or 10 mg) or intravenous palonosetron 0.25 mg. Primary objectives were to establish APF530 noninferiority to palonosetron for preventing acute CINV following MEC or HEC and delayed CINV following MEC and to determine APF530 superiority to palonosetron for preventing delayed CINV following HEC. The primary efficacy end point was complete response (CR [using CI difference for APF530-palonosetron]). A lower confidence bound greater than -15 % indicated noninferiority. In the modified intent-to-treat population (MEC = 634; HEC = 707), both APF530 doses were noninferior to palonosetron in preventing acute CINV after MEC (CRs 74.8 % [-9.8, 9.3] and 76.9 % [-7.5, 11.4], respectively, vs. 75.0 % palonosetron) and after HEC (CRs 77.7 % [-11.5, 5.5] and 81.3 % [-7.7, 8.7], respectively, vs. 80.7 % palonosetron). APF530 500 mg was noninferior to palonosetron in preventing delayed CINV after MEC (CR 58.5 % [-9.5, 12.1] vs. 57.2 % palonosetron) but not superior in preventing delayed CINV after HEC. Adverse events were generally mild and unrelated to treatment, the most common (excluding injection-site reactions) being constipation. A single subcutaneous APF530 injection offers a convenient alternative to palonosetron for preventing acute and delayed CINV after MEC or HEC.

Ground biomass assessment of shrub species in tehsil takht-e-nasrati, pakistan

International Nuclear Information System (INIS)

Khan, M.; Hussain, F.; Musharaf, S.; Musharaf, S.

2014-01-01

The shrub biomass of different species of Tehsil Takht-e-Nasrati was different at different altitude. In the present study it was found that the average shrub biomass was decreasing with increasing altitude. Result confirms that the biomass of Saccharum bengalense was high 5020.38 Kg.hec/sup -1/ in phase 1 and phase 2 (4331.58 Kg.hec/sup -1/). The highest ground biomass 1125.1 Kg.hec/sup -1/ of Zizyphus nummularia was found in Phase 3. Furthermore in Phase 4 the biomass of Capparis deciduas was high 437.79 Kg.hec/sup -1/. Along with shrubs average biomass of Saccharum bengalense was high 2665.12 Kg.hec/sup -1/ and low 13.47 Kg.hec/sup -1/ of Cassia angustifolia. With seasons the biomass of Saccharum bengalense (13800 Kg.hec/sup -1/) was greater during winter at Phase 1 and Periploc aaphylla (12.35 Kg.hec-1) biomass was lowers during spring at Phase 4. In comparison in season the biomass was high in winter due to the dormant stage of shrubs in phase 1 while it was low in summer in phase 4. In winter the grazing process was stop due to agriculture point of view while in hilly area the grazing was high and the low percentage of rain fall consequently the biomass was high in plain area as contrast to hilly area. The biomass of shrubs is high in winter while it was low in summer as the grazing and palatability rate was high in summer as well as low in winter. The assessment of shrub biomass in research area is a requirement for successful management at the same time as it gives a complete documentation for the area in complexity and work out unpredictable resources to help imagine shrubs potency and behavior. (author)

Comparison of two plethysmography systems in assessment of forearm blood flow.

Science.gov (United States)

Leslie, Stephen J; Attinà, Teresa; Hultsch, Ellen; Bolscher, Luc; Grossman, Matthias; Denvir, Martin A; Webb, David J

2004-05-01

Venous occlusion plethysmography is widely used to assess forearm blood flow (FBF). We compared the established Hokanson system (HEC4) with a newly developed Filtrass 2001 system (F2001). The HEC4 uses mercury-in-Silastic strain gauges, whereas F2001 detects volume changes with a nonmercury linear displacement device. The aim of this study was to evaluate the new F2001 against the HEC4 in terms of repeatability and systematic bias. Ten subjects were studied on 4 separate days in random order using either the HEC4 on both arms, the F2001 on both arms, the HEC4 on the right arm with the F2001 on the left, or the F2001 on the right arm and the HEC4 on the left. Stroop's colored word conflict test and postocclusive hyperemia were used to increase FBF, and lower body negative pressure was used to lower FBF. Stroop's colored word conflict test and lower body negative pressure increased (24.6 +/- 1.5%, n = 240, P 0.05), and there was no systematic bias. The F2001 is a newly developed plethysmography system that does not utilize mercury and is suitable for assessing changes of FBF in physiological studies.

Ethics policy review: a case study in quality improvement.

Science.gov (United States)

Frolic, Andrea Nadine; Drolet, Katherine

2013-02-01

Policy work is often cited as one of the primary functions of Hospital Ethics Committees (HECs), along with consultation and education. Hospital policies can have far reaching effects on a wide array of stakeholders including, care providers, patients, families, the culture of the organisation and the community at large. In comparison with the wealth of information available about the emerging practice of ethics consultation, relatively little attention has been paid to the policy work of HECs. In this paper, we hope to advance the development of best practices in HEC policy work by describing the quality improvement process that we undertook at Hamilton Health Sciences, Hamilton, Ontario, Canada. In the first section of the paper we describe the context of our HEC policy work, and the shortcomings of our historical review process. In subsequent sections, we detail the quality improvement project we undertook in 2010, the results of the project and the specific tools we developed to enhance the quality of HEC policy work. Our goal in sharing this organisational case study is to prompt other HECs to publish qualitative descriptions of their policy work, in order to generate a body of knowledge that can inform the development of best practices for ethics policy review.

Missouri River Recovery Management Plan and Environmental Impact Statement

Science.gov (United States)

2014-04-11

Proficient in hydrologic and hydraulic engineering computer models, particularly ResSim and HEC - RAS ; working experience with large river systems including...Description of the Model and How It Will Be Applied in the Study Approval Status HEC - RAS The function of this model is to conduct one-dimensional hydraulic...calculations for a full network of natural and man- made channels. HEC - RAS is a model central to the forecasting of physical conditions for

Ririe Dam Release Test Assessment

Science.gov (United States)

2013-06-01

Notes HEC - RAS Location Station (ft) Observation Notes 1420 Ririe Dam Ririe Dam 119,880 Gates opened and initial release started. 1455 115th St...16°F air temperature. Table A2. Observations made on 11 February 2013. Time Location Notes HEC - RAS Location Station (ft) Observation Notes...ERDC/CRREL TR-13-10 52 Time Location Notes HEC - RAS Location Station (ft) Observation Notes Travel Time* (sec) Vel.** (fps) 1224 5th

Overexpression of the LH receptor increases distant metastases in an endometrial cancer mouse model

Directory of Open Access Journals (Sweden)

Serena ePillozzi

2013-11-01

Full Text Available Objective. The aim of the present study was to define the role of luteinizing hormone receptor (LH-R expression in endometrial cancer (EC, using preclinical mouse models, to further transfer these data to the clinical setting. Methods. The role of LH-R over-expression was studied using EC cells (Hec1A, e.g. cells with low endogenous LH-R expression transfected with the LH-R (Hec1A-LH-R. In vitro cell proliferation was measured through the WST1 assay, whereas cell invasion was measured trough the matrigel assay. The effects of LH/hCG-R overexpresion in vivo were analyzed in an appropriately developed preclinical mouse model of EC, which mimicked postmenopausal conditions. The model consisted in an orthotopic xenograft of Hec1A cells into immunodeficient mice treated daily with recombinant LH, to assure high levels of LH. Results. In vitro data indicated that LH-R overexpression increased Hec1A invasiveness. In vivo results showed that tumors arising from Hec1A-LH-R cells injection displayed a higher local invasion and a higher number of distant metastases, mainly in the lung, compared to tumors obtained from the injection of Hec1A cells. LH withdrawl strongly inhibited local and distant metastatic spread of tumors, especially those arising from Hec1A-LH-R cells. Conclusions. The overexpression of the LH-R increases the ability of EC cells to undergo local invasion and metastatic spread. This occurs in the presence of high LH serum concentrations.

Problem-elephant translocation: translocating the problem and the elephant?

Directory of Open Access Journals (Sweden)

Prithiviraj Fernando

Full Text Available Human-elephant conflict (HEC threatens the survival of endangered Asian elephants (Elephas maximus. Translocating "problem-elephants" is an important HEC mitigation and elephant conservation strategy across elephant range, with hundreds translocated annually. In the first comprehensive assessment of elephant translocation, we monitored 16 translocations in Sri Lanka with GPS collars. All translocated elephants were released into national parks. Two were killed within the parks where they were released, while all the others left those parks. Translocated elephants showed variable responses: "homers" returned to the capture site, "wanderers" ranged widely, and "settlers" established home ranges in new areas soon after release. Translocation caused wider propagation and intensification of HEC, and increased elephant mortality. We conclude that translocation defeats both HEC mitigation and elephant conservation goals.

2016 Updated MASCC/ESMO Consensus Recommendations

DEFF Research Database (Denmark)

Herrstedt, Jørn; Roila, Fausto; Warr, David

2017-01-01

PURPOSE: This review summarizes the recommendations for the prophylaxis of nausea and vomiting in adults receiving highly emetogenic chemotherapy (HEC) which includes cisplatin, mechlorethamine, streptozocin, cyclophosphamide >1500 mg/m(2), carmustine, dacarbazine, and the combination of an anthr......PURPOSE: This review summarizes the recommendations for the prophylaxis of nausea and vomiting in adults receiving highly emetogenic chemotherapy (HEC) which includes cisplatin, mechlorethamine, streptozocin, cyclophosphamide >1500 mg/m(2), carmustine, dacarbazine, and the combination...... antagonists (netupitant and rolapitant) have been included in the updated recommendations as additional options to aprepitant or fosaprepitant. Addition of one of these NK1-receptor antagonists to a combination of a 5-HT3-receptor antagonist and dexamethasone is recommended in both non-AC HEC and AC HEC...

Analyses of ionic conductivity and dielectric behavior of solid polymer electrolyte based 2-hydroxyethyl cellulose doped ammonium nitrate plasticized with ethylene carbonate

Science.gov (United States)

Hafiza, M. N.; Isa, M. I. N.

2017-09-01

A solid polymer electrolyte (SPE) based 2-hydroxyethyl cellulose (2-HEC) doped ammonium nitrate (NH4NO3) plasticized with ethylene carbonate (EC) has been investigated using electrical impedance spectroscopy (EIS). The highest ionic conductivity of (1.17±0.01) × 10-3 Scm-1 was obtained for 2-HEC-NH4NO3 plasticized with 16 wt.% EC. Dielectric and modulus study showed non-Debye type of 2-HEC-NH4NO3-EC SPE.

Preparation and characterization of poly(acrylic acid)-hydroxyethyl cellulose graft copolymer.

Science.gov (United States)

Abdel-Halim, E S

2012-10-01

Poly(acrylic acid) hydroxyethyl cellulose [poly(AA)-HEC] graft copolymer was prepared by polymerizing acrylic acid (AA) with hydroxyethyl cellulose (HEC) using potassium bromate/thiourea dioxide (KBrO(3)/TUD) as redox initiation system. The polymerization reaction was carried out under a variety of conditions including concentrations of AA, KBrO(3) and TUD, material to liquor ratio and polymerization temperature. The polymerization reaction was monitored by withdrawing samples from the reaction medium and measuring the total conversion. The rheological properties of the poly(AA)-HEC graft copolymer were investigated. The total conversion and rheological properties of the graft copolymer depended on the ratio of KBrO(3) to TUD and on acrylic acid concentration as well as temperature and material to liquor ratio. Optimum conditions of the graft copolymer preparation were 30 mmol KBrO(3) and 30 mmol TUD/100g HEC, 100% AA (based on weight of HEC), duration 2h at temperature 50 °C using a material to liquor ratio of 1:10. Copyright © 2012. Published by Elsevier Ltd.

Granisetron Extended-Release Injection: A Review in Chemotherapy-Induced Nausea and Vomiting.

Science.gov (United States)

Deeks, Emma D

2016-12-01

An extended-release (ER) subcutaneously injectable formulation of the first-generation 5-HT 3 receptor antagonist granisetron is now available in the USA (Sustol ® ), where it is indicated for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) following moderately emetogenic chemotherapy (MEC) or anthracycline and cyclophosphamide combination chemotherapy regimens in adults. Granisetron ER is administered as a single subcutaneous injection and uses an erosion-controlled drug-delivery system to allow prolonged granisetron release. Primary endpoint data from phase III studies after an initial cycle of chemotherapy indicate that, when used as part of an antiemetic regimen, granisetron ER injection is more effective than intravenous ondansetron in preventing delayed CINV following highly emetogenic chemotherapy (HEC); is noninferior to intravenous palonosetron in preventing both acute CINV following MEC or HEC and delayed CINV following MEC; and is similar, but not superior, to palonosetron in preventing delayed CINV following HEC. The benefits of granisetron ER were seen in various patient subgroups, including those receiving anthracycline plus cyclophosphamide-based HEC, and (in an extension of one of the studies) over multiple MEC or HEC cycles. Granisetron ER injection is generally well tolerated, with an adverse event profile similar to that of ondansetron or palonosetron. Thus, granisetron ER injection expands the options for preventing both acute and delayed CINV in adults with cancer receiving MEC or anthracycline plus cyclophosphamide-based HEC.

Dynamics of 14C-labeled glucose and ammonium in saline arable soils

International Nuclear Information System (INIS)

Vuelvas-Solorzano, Alma; Hernandez-Matehuala, Rosalina; Conde-Barajas, Eloy; Cardenas-Manriquez, Marcela; Luna-Guido, Marco L.; Dendooven, Luc

2009-01-01

Organic matter dynamics and nutrient availability in saline agricultural soils of the State of Guanajuato might provide information for remediation strategies. 14 C labeled glucose with or without 200 mg kg - 1 of NH 4 + -N soil was added to two clayey agricultural soils with different electrolytic conductivity (EC), i.e. 0.94 dS m - 1 (low EC; LEC) and 6.72 dS m - 1 (high EC; HEC), to investigate the effect of N availability and salt content on organic material decomposition. Inorganic N dynamics and production of CO 2 and 14 CO 2 were monitored. Approximately 60 % of the glucose- 14 C added to LEC soil evolved as 14 CO 2 , but only 20 % in HEC soil after the incubation period of 21 days. After one day, 14 C was extractable from LEC soil, but > 500 mg 14 C from HEC soil. No N mineralization occurred in the LEC and HEC soils and glucose addition reduced the concentrations of inorganic N in unamended soil and soil amended with NH 4 + -N. The NO 2 - and NO 3 - concentrations were on average higher in LEC than in HEC soil, with exception of NO 2 - in HEC amended with NH 4 + -N. It was concluded that increases in soil EC reduced mineralization of the easily decomposable C substrate and resulted in N-depleted soil. (author)

Jackson Bar Training Structure Study

Science.gov (United States)

2015-05-01

comparison of the one-dimensional bridge hydraulic routines from: HEC - RAS , HEC -2, and WSPRO. Davis, CA: U.S. Army Corps of Engineers, Hydrologic Engineering...ER D C/ CH L TR -1 5- 4 Jackson Bar Training Structure Study Co as ta l a nd H yd ra ul ic s La bo ra to ry Jeremy A. Sharp and...Leroy Gage), a previously constructed HEC -2 model, and a previously constructed WES physical model from 1987. Three alternatives were modeled in an

AutoRoute Rapid Flood Inundation Model

Science.gov (United States)

2013-03-01

cross-section data does not exist. As such, the AutoRoute model is not meant to be as accurate as models such as HEC - RAS (U.S. Army Engineer...such as HEC - RAS assume that the defined low point of cross sections must be connected. However, in this approach the channel is assumed to be defined...Res. 33(2): 309-319. U.S. Army Engineer Hydrologic Engineering Center. 2010. “ HEC - RAS : River Analysis System, User’s Manual, Version 4.1.” Davis

Mount St. Helens Long-Term Sediment Management Plan for Flood Risk Reduction

Science.gov (United States)

2010-06-01

9.3.2. A mobile bed HEC - RAS model of the lower 20 miles of the Cowlitz River has been created using 2008 bathymetric data and bed gradation data...to regulated flows. Modeling Results An existing uncalibrated mobile-bed HEC - RAS model of the lower Cowlitz River was run for water years 2007 and...June 2010 C-39 Analysis Stage An existing steady state HEC - RAS model of the lower Cowlitz extending from the Columbia River to the confluence with

High-End Computing Challenges in Aerospace Design and Engineering

Science.gov (United States)

Bailey, F. Ronald

2004-01-01

High-End Computing (HEC) has had significant impact on aerospace design and engineering and is poised to make even more in the future. In this paper we describe four aerospace design and engineering challenges: Digital Flight, Launch Simulation, Rocket Fuel System and Digital Astronaut. The paper discusses modeling capabilities needed for each challenge and presents projections of future near and far-term HEC computing requirements. NASA's HEC Project Columbia is described and programming strategies presented that are necessary to achieve high real performance.

Small Molecule TH-39 Potentially Targets Hec1/Nek2 Interaction and Exhibits Antitumor Efficacy in K562 Cells via G0/G1 Cell Cycle Arrest and Apoptosis Induction.

Science.gov (United States)

Zhu, Yongxia; Wei, Wei; Ye, Tinghong; Liu, Zhihao; Liu, Li; Luo, Yong; Zhang, Lidan; Gao, Chao; Wang, Ningyu; Yu, Luoting

2016-01-01

Cancer is still a major public health issue worldwide, and new therapeutics with anti-tumor activity are still urgently needed. The anti-tumor activity of TH-39, which shows potent anti-proliferative activity against K562 cells with an IC50 of 0.78 µM, was investigated using immunoblot, co-immunoprecipitation, the MTT assay, and flow cytometry. Mechanistically, TH-39 may disrupt the interaction between Hec1 and Nek2 in K562 cells. Moreover, TH-39 inhibited cell proliferation in a concentration- and time-dependent manner by influencing the morphology of K562 cells and inducing G0/G1 phase arrest. G0/G1 phase arrest was associated with down-regulation of CDK2-cyclin E complex and CDK4/6-cyclin D complex activities. Furthermore, TH-39 also induced cell apoptosis, which was associated with activation of caspase-3, down-regulation of Bcl-2 expression and up-regulation of Bax. TH-39 could also decrease mitochondrial membrane potential (Δψm) and increase reactive oxygen species (ROS) accumulation in K562 cells. The results indicated that TH-39 might induce apoptosis via the ROS-mitochondrial apoptotic pathway. This study highlights the potential therapeutic efficacy of the anti-cancer compound TH-39 in treatment-resistant chronic myeloid leukemia. © 2016 The Author(s) Published by S. Karger AG, Basel.

Slow-release granisetron (APF530) versus palonosetron for chemotherapy-induced nausea/vomiting: analysis by American Society of Clinical Oncology emetogenicity criteria.

Science.gov (United States)

Raftopoulos, Harry; Boccia, Ralph; Cooper, William; O'Boyle, Erin; Gralla, Richard J

2015-09-01

APF530 is a novel sustained-release formulation of granisetron. In a Phase III trial, APF530 500 mg was noninferior to palonosetron 0.25 mg in preventing acute chemotherapy-induced nausea and vomiting (CINV) after moderately (MEC) or highly emetogenic chemotherapy (HEC) and delayed CINV after MEC, but not superior in preventing delayed CINV after HEC. Emetogenicity was classified by Hesketh criteria; this reanalysis uses newer American Society of Clinical Oncology criteria. Complete responses (no emesis or rescue medication) after cycle one were reanalyzed after reclassification of MEC and HEC by American Society of Clinical Oncology criteria. APF530 maintained noninferiority to palonosetron. Single-dose APF530 is a promising alternative to palonosetron for preventing acute and delayed CINV after MEC or HEC. The Clinicaltrials.gov identifier for this study is NCT00343460.

ATLAS HEC PHOTOS TRIUMF

CERN Multimedia

1997-01-01

Photo 1 - Removal of a glued foil from the glue press. The foils still need to be cut with a steel rule die and the HV pins soldered on. Photo 2 - Inspection of EST foil. Photo 3 - Placing the first plate of the front Module 0 on the stacking table with the tie-rods in place. Photo 4 - As each gap is stacked, it is tested by applying 3kV across each honeycomb sheet and ensuring that the current draw is low (a few tens of nA). Photo 5 - HV testing on a stacked front module. Photo 6 - Detail of a gap in a module. Four sheets of honeycomb spacing mats separate the centre PAD foil from the two EST foils on either side, and hold the EST foils away from the copper absorber structure. Photo 7 - Last plate of rear module being stacked. Photo 8 - Stacked rear module 0. Photo 9 - Four Module 0's, one front and one rear from TRIUMF, one from Germany, and one from and one from Russia, are "married" into one structure. In this picture, two front modules are married together. Photo 10 - After two modules are married, they ...

Improving predictions of the effects of extreme events, land use, and climate change on the hydrology of watersheds in the Philippines

Directory of Open Access Journals (Sweden)

R. Benavidez

2016-05-01

Full Text Available Due to its location within the typhoon belt, the Philippines is vulnerable to tropical cyclones that can cause destructive floods. Climate change is likely to exacerbate these risks through increases in tropical cyclone frequency and intensity. To protect populations and infrastructure, disaster risk management in the Philippines focuses on real-time flood forecasting and structural measures such as dikes and retaining walls. Real-time flood forecasting in the Philippines mostly utilises two models from the Hydrologic Engineering Center (HEC: the Hydrologic Modeling System (HMS for watershed modelling, and the River Analysis System (RAS for inundation modelling. This research focuses on using non-structural measures for flood mitigation, such as changing land use management or watershed rehabilitation. This is being done by parameterising and applying the Land Utilisation and Capability Indicator (LUCI model to the Cagayan de Oro watershed (1400 km2 in southern Philippines. The LUCI model is capable of identifying areas providing ecosystem services such as flood mitigation and agricultural productivity, and analysing trade-offs between services. It can also assess whether management interventions could enhance or degrade ecosystem services at fine spatial scales. The LUCI model was used to identify areas within the watershed that are providing flood mitigating services and areas that would benefit from management interventions. For the preliminary comparison, LUCI and HEC-HMS were run under the same scenario: baseline land use and the extreme rainfall event of Typhoon Bopha. The hydrographs from both models were then input to HEC-RAS to produce inundation maps. The novelty of this research is two-fold: (1 this type of ecosystem service modelling has not been carried out in the Cagayan de Oro watershed; and (2 this is the first application of the LUCI model in the Philippines. Since this research is still ongoing, the results presented in

Improving predictions of the effects of extreme events, land use, and climate change on the hydrology of watersheds in the Philippines

Science.gov (United States)

Benavidez, Rubianca; Jackson, Bethanna; Maxwell, Deborah; Paringit, Enrico

2016-05-01

Due to its location within the typhoon belt, the Philippines is vulnerable to tropical cyclones that can cause destructive floods. Climate change is likely to exacerbate these risks through increases in tropical cyclone frequency and intensity. To protect populations and infrastructure, disaster risk management in the Philippines focuses on real-time flood forecasting and structural measures such as dikes and retaining walls. Real-time flood forecasting in the Philippines mostly utilises two models from the Hydrologic Engineering Center (HEC): the Hydrologic Modeling System (HMS) for watershed modelling, and the River Analysis System (RAS) for inundation modelling. This research focuses on using non-structural measures for flood mitigation, such as changing land use management or watershed rehabilitation. This is being done by parameterising and applying the Land Utilisation and Capability Indicator (LUCI) model to the Cagayan de Oro watershed (1400 km2) in southern Philippines. The LUCI model is capable of identifying areas providing ecosystem services such as flood mitigation and agricultural productivity, and analysing trade-offs between services. It can also assess whether management interventions could enhance or degrade ecosystem services at fine spatial scales. The LUCI model was used to identify areas within the watershed that are providing flood mitigating services and areas that would benefit from management interventions. For the preliminary comparison, LUCI and HEC-HMS were run under the same scenario: baseline land use and the extreme rainfall event of Typhoon Bopha. The hydrographs from both models were then input to HEC-RAS to produce inundation maps. The novelty of this research is two-fold: (1) this type of ecosystem service modelling has not been carried out in the Cagayan de Oro watershed; and (2) this is the first application of the LUCI model in the Philippines. Since this research is still ongoing, the results presented in this paper are

The impact of 5-hydroxytryptamine-receptor antagonists on chemotherapy treatment adherence, treatment delay, and nausea and vomiting

International Nuclear Information System (INIS)

Palli, Swetha Rao; Grabner, Michael; Quimbo, Ralph A; Rugo, Hope S

2015-01-01

To determine the incidence of chemotherapy-induced nausea/vomiting (CINV) and chemotherapy treatment delay and adherence among patients receiving palonosetron versus other 5-hydroxytryptamine receptor antagonist (5-HT 3 RA) antiemetics. This retrospective claims analysis included adults with primary malignancies who initiated treatment consisting of single-day intravenous highly emetogenic chemotherapy (HEC) or moderately EC (MEC) regimens. Treatment delay was defined as a gap in treatment at least twice the National Comprehensive Cancer Network-specified cycle length, specific to each chemotherapy regimen. Treatment adherence was determined by the percentage of patients who received the regimen-specific recommended number of chemotherapy cycles within the recommended time frame. We identified 1,832 palonosetron and 2,387 other 5-HT 3 RA (“other”) patients who initiated HEC therapy, and 1,350 palonosetron users and 1,379 patients on other antiemetics who initiated MEC therapy. Fewer patients receiving palonosetron experienced CINV versus other (HEC, 27.5% versus 32.2%, P=0.0011; MEC, 36.1% versus 41.7%, P=0.0026), and fewer treatment delays occurred among patients receiving palonosetron versus other (HEC, 3.2% versus 6.0%, P<0.0001; MEC, 17.0% versus 26.8%, P<0.0001). Compared with the other cohort, patients receiving palonosetron were significantly more adherent to the index chemotherapy regimen with respect to the recommended time frame (HEC, 74.7% versus 69.7%, P=0.0004; MEC, 43.1% versus 37.3%, P=0.0019) and dosage (HEC, 27.3% versus 25.8%, P=0.0004; MEC, 15.0% versus 12.6%, P=0.0019). Palonosetron more effectively reduced occurrence of CINV in patients receiving HEC or MEC compared with other agents in this real-world setting. Additionally, patients receiving palonosetron had better adherence and fewer treatment delays than patients receiving other 5-HT 3 RAs

1995 project of the year Hanford Environmental compliance project nomination

Energy Technology Data Exchange (ETDEWEB)

Kelly, J.R.

1996-02-01

The completion of the Hanford Environmental Compliance (HEC) Project in December 1995 brought to a successful close a long line of major contributions to environmental cleanup. Not since the early days of the Hanford Site during and shortly after World War 11 had such a large group of diverse construction activities, with a common goal, been performed at Hanford. Key to this success was the unique combination of 14 subprojects under the HEC Project which afforded the flexibility to address evolving subproject requirements. This strategy resulted in the accomplishment of the HEC Project stakeholders` objectives on an aggressive schedule, at a $33 million cost savings to the customer. The primary objectives of the HEC Project were to upgrade selected Hanford Site facilities and systems to bring them into compliance with current environmental standards and regulations. The HEC Project contributed significantly towards the Hanford site compliance with Clean Water Act, Resource Conservation and Recovery Act (RCRA) and Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) requirements. It provided, in part, those construction activities required to comply with those requirements in the areas of liquid and solid waste treatment and disposal, waste characterization, and groundwater monitoring.

1995 project of the year Hanford Environmental compliance project nomination

International Nuclear Information System (INIS)

Kelly, J.R.

1996-02-01

The completion of the Hanford Environmental Compliance (HEC) Project in December 1995 brought to a successful close a long line of major contributions to environmental cleanup. Not since the early days of the Hanford Site during and shortly after World War 11 had such a large group of diverse construction activities, with a common goal, been performed at Hanford. Key to this success was the unique combination of 14 subprojects under the HEC Project which afforded the flexibility to address evolving subproject requirements. This strategy resulted in the accomplishment of the HEC Project stakeholders' objectives on an aggressive schedule, at a $33 million cost savings to the customer. The primary objectives of the HEC Project were to upgrade selected Hanford Site facilities and systems to bring them into compliance with current environmental standards and regulations. The HEC Project contributed significantly towards the Hanford site compliance with Clean Water Act, Resource Conservation and Recovery Act (RCRA) and Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) requirements. It provided, in part, those construction activities required to comply with those requirements in the areas of liquid and solid waste treatment and disposal, waste characterization, and groundwater monitoring

A GIS based approach for the prediction of the dam break flood hazard – A case study of Zardezas reservoir “Skikda, Algeria”

Directory of Open Access Journals (Sweden)

Derdous Oussama

2015-12-01

Full Text Available The construction of dams in rivers can offer many advantages, however the consequences resulting from their failure could result in major damage, including loss of life and property destruction. To mitigate the threats of dam break it is essential to appreciate the characteristics of the potential flood in realistic manner. In this study an approach based on the integration of hydraulic modelling and GIS has been used to assess the risks resulting from a potential failure of Zardezas dam, a concrete dam located in Skikda, in the North East of Algeria. HEC-GeoRAS within GIS was used to extract geometric information from a digital elevation model and then imported into HEC-RAS. Flow simulation of the dam break was performed using HEC-RAS and results were mapped using the GIS. Finally, a flood hazard map based on water depth and flow velocity maps was created in GIS environment. According to this map the potential failure of Zardezas dam will place a large number in people in danger. The present study has shown that Application of Geographical Information System (GIS techniques in integration with hydraulic modelling can significantly reduce the time and the resources required to forecast potential dam break flood hazard which can play a crucial role in improving both flood disaster management and land use planning downstream of dams.

Managing water and riparian habitats on the Bill Williams River with scientific benefit for other desert river systems

Science.gov (United States)

John Hickey,; Woodrow Fields,; Andrew Hautzinger,; Steven Sesnie,; Shafroth, Patrick B.; Dick Gilbert,

2016-01-01

This report details modeling to: 1) codify flow-ecology relationships for riparian species of the Bill Williams River as operational guidance for water managers, 2) test the guidance under different climate scenarios, and 3) revise the operational guidance as needed to address the effects of climate change. Model applications detailed herein include the River Analysis System  (HEC-RAS) and the Ecosystem Functions Model  (HEC-EFM), which was used to generate more than three million estimates of local seedling recruitment areas. Areas were aggregated and compared to determine which scenarios generated the most seedling area per unit volume of water. Scenarios that maximized seedling area were grouped into a family of curves that serve as guidance for water managers. This work has direct connections to water management decision-making and builds upon and adds to the rich history of science-based management for the Bill Williams River, Arizona, USA. 

A model study of bridge hydraulics

Science.gov (United States)

2010-08-01

Most flood studies in the United States use the Army Corps of Engineers HEC-RAS (Hydrologic Engineering : Centers River Analysis System) computer program. This study was carried out to compare results of HEC-RAS : bridge modeling with laboratory e...

The impact of 5-hydroxytryptamine-receptor antagonists on chemotherapy treatment adherence, treatment delay, and nausea and vomiting.

Science.gov (United States)

Palli, Swetha Rao; Grabner, Michael; Quimbo, Ralph A; Rugo, Hope S

2015-01-01

To determine the incidence of chemotherapy-induced nausea/vomiting (CINV) and chemotherapy treatment delay and adherence among patients receiving palonosetron versus other 5-hydroxytryptamine receptor antagonist (5-HT3 RA) antiemetics. This retrospective claims analysis included adults with primary malignancies who initiated treatment consisting of single-day intravenous highly emetogenic chemotherapy (HEC) or moderately EC (MEC) regimens. Treatment delay was defined as a gap in treatment at least twice the National Comprehensive Cancer Network-specified cycle length, specific to each chemotherapy regimen. Treatment adherence was determined by the percentage of patients who received the regimen-specific recommended number of chemotherapy cycles within the recommended time frame. We identified 1,832 palonosetron and 2,387 other 5-HT3 RA ("other") patients who initiated HEC therapy, and 1,350 palonosetron users and 1,379 patients on other antiemetics who initiated MEC therapy. Fewer patients receiving palonosetron experienced CINV versus other (HEC, 27.5% versus 32.2%, P=0.0011; MEC, 36.1% versus 41.7%, P=0.0026), and fewer treatment delays occurred among patients receiving palonosetron versus other (HEC, 3.2% versus 6.0%, PHEC, 74.7% versus 69.7%, P=0.0004; MEC, 43.1% versus 37.3%, P=0.0019) and dosage (HEC, 27.3% versus 25.8%, P=0.0004; MEC, 15.0% versus 12.6%, P=0.0019). Palonosetron more effectively reduced occurrence of CINV in patients receiving HEC or MEC compared with other agents in this real-world setting. Additionally, patients receiving palonosetron had better adherence and fewer treatment delays than patients receiving other 5-HT3 RAs.

Dynamics of {sup 14}C-labeled glucose and ammonium in saline arable soils

Energy Technology Data Exchange (ETDEWEB)

Vuelvas-Solorzano, Alma; Hernandez-Matehuala, Rosalina [Instituto Tecnologico de Celaya, Celaya Gto. (Mexico). Dept. de Ing. Bioquimica. Lab. de Bioingenieria; Conde-Barajas, Eloy; Cardenas-Manriquez, Marcela [Instituto Tecnologico de Celaya, Celaya Gto. (Mexico). Dept. de Ing. Ambiental. Lab. de Bioingenieria], e-mail: marcela@itc.mx; Luna-Guido, Marco L.; Dendooven, Luc [Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional (Cinvestav), D.F. (Mexico). Dept. de Biotecnologia y Bioingenieria. Lab. de Ecologia de Suelos], e-mail: dendoove@cinvestav.mx

2009-07-15

Organic matter dynamics and nutrient availability in saline agricultural soils of the State of Guanajuato might provide information for remediation strategies. {sup 14}C labeled glucose with or without 200 mg kg{sup -}1 of NH{sub 4} {sup +}-N soil was added to two clayey agricultural soils with different electrolytic conductivity (EC), i.e. 0.94 dS m{sup -}1 (low EC; LEC) and 6.72 dS m{sup -}1 (high EC; HEC), to investigate the effect of N availability and salt content on organic material decomposition. Inorganic N dynamics and production of CO{sub 2} and {sup 14}CO{sub 2} were monitored. Approximately 60 % of the glucose-{sup 14}C added to LEC soil evolved as {sup 14}CO{sub 2}, but only 20 % in HEC soil after the incubation period of 21 days. After one day, < 200 mg {sup 14}C was extractable from LEC soil, but > 500 mg {sup 14}C from HEC soil. No N mineralization occurred in the LEC and HEC soils and glucose addition reduced the concentrations of inorganic N in unamended soil and soil amended with NH{sub 4}{sup +}-N. The NO{sub 2}{sup -} and NO{sub 3}{sup -} concentrations were on average higher in LEC than in HEC soil, with exception of NO{sub 2}{sup -} in HEC amended with NH{sub 4}{sup +}-N. It was concluded that increases in soil EC reduced mineralization of the easily decomposable C substrate and resulted in N-depleted soil. (author)

Breeding of a sake yeast mutant with enhanced ethyl caproate productivity in sake brewing using rice milled at a high polishing ratio.

Science.gov (United States)

Takahashi, Toshinari; Ohara, Yusuke; Sueno, Kazuo

2017-06-01

Sake yeast produces a fruity flavor known as ginjo-ko-which is mainly attributable to ethyl caproate and isoamyl acetate-during fermentation in sake brewing. The production of these flavor components is inhibited by unsaturated fatty acids derived from the outer layer of rice as raw material. We isolated three mutants (hec2, hec3, and hec6) with enhanced ethyl caproate productivity in sake brewing using rice milled at a high polishing ratio from a cerulenin-resistant mutant derived from the hia1 strain, which shows enhanced isoamyl acetate productivity. The hec2 mutant had the homozygous FAS2 mutation Gly1250Ser, which is known to confer high ethyl caproate productivity. When the homozygous FAS2 mutation Gly1250Ser was introduced into strain hia1, ethyl caproate productivity was increased but neither this nor intracellular caproic acid content approached the levels observed in the hec2 mutant, indicating that a novel mutation was responsible for the high ethyl caproate productivity. We also found that the expression of EEB1 encoding acyl-coenzyme A:ethanol O-acyltransferase (AEATase) and enzymatic activity were increased in the hec2 mutant. These results suggest that the upregulation of EEB1 expression and AEATase activity may also have contributed to the enhancement of ethyl caproate synthesis from ethanol and caproyl-CoA. Our findings are useful for the brewing of sake with improved flavor due to high levels of isoamyl acetate and ethyl caproate. Copyright © 2017 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

HPMC supplementation reduces abdominal fat content, intestinal permeability, inflammation, and insulin resistance in diet-induced obese mice

Science.gov (United States)

Cationic hydroxyethyl cellulose (cHEC) , was fed to hamsters to determine if this new soluble fiber had an effect on hypercholesterolemia and dyslipidemia associated with cardiovascular disease. In this study, Golden Syrian hamsters were supplemented with 3-8% cHEC or microcrystalline cellulose (MC...

Adhesion of cultured human endothelial cells onto methacrylate polymers with varying surface wettability and charge

NARCIS (Netherlands)

van Wachem, P.B.; Hogt, A.H.; Beugeling, T.; Feijen, Jan; Bantjes, A.; Detmers, J.P.; van Aken, W.G.

1987-01-01

The adhesion of human endothelial cells (HEC) onto a series of well-characterized methacrylate polymer surfaces with varying wettabilities and surface charges was studied either in serum-containing (CMS) or in serum-free (CM) culture medium. HEC adhesion in CMS onto (co)polymers * of hydroxyethyl

HYDROLOGIC AND HYDRAULIC MODELLING INTEGRATED WITH GIS: A STUDY OF THE ACARAÚ RIVER BASIN – CE

Directory of Open Access Journals (Sweden)

Samuellson Lopes Cabral

2014-01-01

Full Text Available The paper presents a case study integrating hydrologic models, hydraulic models and a geographic information system (GIS to delineate flooded areas in the medium-sized Acaraú River Basin in Ceará State, Brazil. The computational tools used were HEC-HMS for hydrologic modelling, HEC-RAS for hydraulic modelling and HEC-GeoRAS for the GIS. The results showed that a substantial portion of the riverine populations of the cities of Sobral, Santana do Acaraú and Groairas were affected by floods. Overall, the flood model satisfactorily represents the affected areas and shows the locations with the greatest flooding.

Impact of periodic health examination on surgical treatment for uterine fibroids in Beijing: a case-control study

Directory of Open Access Journals (Sweden)

Yang Ling-Ling

2010-12-01

Full Text Available Abstract Background During the past 2 decades, there has been a rapid proliferation of "health examination center (HEC" across China. The effects of their services on public's health have not been systemically investigated. This study aimed to assess the impact of periodic health examination (PHE at HEC on surgical treatment for uterine fibroids in Beijing residents. Methods We identified 224 patients with a primary diagnosis of uterine fibroids who had surgical treatment at four Level-1 general hospitals in Beijing, from June 1, 2009 to October 20, 2009. Controls were women who did not have surgery for uterine fibroids, matched (1:1 ratio for age (within 2 years. A standard questionnaire was used to inquire about whether participants had PHE at HEC during the previous 2 years. Results PHE at HEC within 2 years were associated with surgical treatment for uterine fibroids. Odds ratios was 4.05 (95% CI, 2.61-6.29 P Conclusions Our study showed PHE currently provided at HEC in China were associated with significantly increased use of surgical treatment for uterine fibroids in women. Further studies are needed to assess the effects of PHE on clinical as well as on broad societal outcomes in Chinese in contemporary medical settings.

"Flooding Risk Analysis and the Understanding of Hydrological Disturbance due to the Rapid Urbanization in a Low-Scale Subwatershed in Houston Area". ( The project develops a relavant Model of flooding risk assessment to define the connection between increased streamflow/flooding and the rapid urban land development).

Science.gov (United States)

Geldiyev, P.

2017-12-01

Rapid urban development and changing climate influences the frequency and magnitude of flooding in Houston area. This proposed project aims to evaluate the flooding risks with the current and future land use changes by 2040 for one subbasin of the San Jacinto Brazos/Neches-Trinity Coastal basin. Surface environments and streamflow data of the Clear Creek are analyzed and stimulated to discuss the possible impact of urbanization on the occurrence of floods. The streamflow data is analyzed and simulated with the application of the Geographic Information Systems and its extensions. Both hydrologic and hydraulic models of the Clear Creek are created with the use of HEC-HMS and HEC-RAS software. Both models are duplicated for the year 2040, based on projected 2040 Landcover Maps developed by Houston and Galveston Area Council. This project examines a type of contemporary hydrologic disturbance and the interaction between land cover and changes in hydrological processes. Expected results will be very significant for urban development and flooding management.

NASA Advanced Supercomputing Facility Expansion

Science.gov (United States)

Thigpen, William W.

2017-01-01

The NASA Advanced Supercomputing (NAS) Division enables advances in high-end computing technologies and in modeling and simulation methods to tackle some of the toughest science and engineering challenges facing NASA today. The name "NAS" has long been associated with leadership and innovation throughout the high-end computing (HEC) community. We play a significant role in shaping HEC standards and paradigms, and provide leadership in the areas of large-scale InfiniBand fabrics, Lustre open-source filesystems, and hyperwall technologies. We provide an integrated high-end computing environment to accelerate NASA missions and make revolutionary advances in science. Pleiades, a petaflop-scale supercomputer, is used by scientists throughout the U.S. to support NASA missions, and is ranked among the most powerful systems in the world. One of our key focus areas is in modeling and simulation to support NASA's real-world engineering applications and make fundamental advances in modeling and simulation methods.

Estimating runoff from ungauged catchments for reservoir water ...

African Journals Online (AJOL)

The Lower Middle Zambezi Basin is sandwiched between three hydropower ... This study applied a rainfall-runoff model (HEC-HMS) and GIS techniques to ... Missing data were generated using the mean value infilling method. ... A hydrological model, HEC- HMS, was used to simulate runoff from the ungauged catchments.

Deposition of cellular fibronectin and desorption of human serum albumin during adhesion and spreading of human endothelial cells on polymers

NARCIS (Netherlands)

Dekker, A.; Dekker, A.; Beugeling, T.; Beugeling, T.; Wind, H.; Poot, Andreas A.; Bantjes, A.; Bantjes, A.; Feijen, Jan; van Aken, W.G.

1991-01-01

More insight into the mechanism of adhesion of human endothelial cells (HEC) on to polymeric surfaces may lead to the development of improved small-diameter vascular grafts. HEC suspended in 20% human serum-containing culture medium adhere and spread well on moderately water-wettable polymers such

Properties and in vitro drug release of hyaluronic acid-hydroxyethyl cellulose hydrogels for transdermal delivery of isoliquiritigenin.

Science.gov (United States)

Kong, Bong Ju; Kim, Ayoung; Park, Soo Nam

2016-08-20

In the present study, the properties of hydrogel systems based on hyaluronic acid (HA)-hydroxyethyl cellulose (HEC) were investigated for effective transdermal delivery of isoliquiritigenin (ILTG). Hydrogels were synthesized by chemical cross-linking, and network structures were characterised using scanning electron microscopy (SEM) and surface area analyser. Texture properties and swelling of HA-HEC hydrogels were found to be closely linked to cross-linker concentration and swelling medium. Water in HA-HEC hydrogels was found to exist mostly in the form of free water. The viscoelasticity and the network stabilization of the hydrogels were analysed via rheological studies. The release kinetics of the hydrogel followed Fickian diffusion mechanism. In an in vitro skin penetration study, the system substantially improved the delivery of ILTG into the skin. These results indicate that the hydrogel system composed of HA and HEC has potential as a transdermal delivery system, with cross-linking density and the swelling medium influencing the properties. Copyright © 2016 Elsevier Ltd. All rights reserved.

Combustion and agglomeration of aluminized high-energy compositions

International Nuclear Information System (INIS)

Korotkikh, A G; Slyusarskiy, K V; Arkhipov, V A; Glotov, O G

2015-01-01

The results of combustion study for high-energy compositions (HECs) based on ammonium perchlorate (AP), butadiene rubber and ultrafine powder (UFP) aluminum Alex, and agglomeration of metal particles on the burning surface and composition of condensed combustion products (CCPs) are presented. It was found that partial replacement 2 wt. % of Alex by iron UFP in HEC increases the burning rate 1.3—1.4 times at the range of nitrogen pressure 2.0-7.5 MPa and reduces the mean diameter of CCPs particles d 43 from 37.4 μm to 33.5 μm at pressure ∼ 4 MPa. Upon partial replacement 2 wt. % of Alex by boron UFP in HEC the recoil force of gasification products outflow from burning surface is increased by 9 % and the burning rate of HEC does not change in the above pressure range, while the mean diameter of CCPs particles is reduced to 32.6 μm at p ∼ 4 MPa. (paper)

Calcium carbonate growth in the presence of water soluble cellulose ethers

International Nuclear Information System (INIS)

Zhang Fengju; Yang Xinguo; Tian Fei

2009-01-01

Calcium carbonate precipitation was performed in the presence of methyl cellulose (MC) and two kinds of hydroxyethyl cellulose (HEC FD-10000, HEC FD-30000). The results demonstrated that the final product morphology and structure of CaCO 3 crystals are highly sensitive to the concentration of the cellulose ethers aqueous solution. By precisely controlling their concentrations, all these three cellulose ethers solutions have the ability of protecting metastable vaterite from thermodynamically transforming into stable calcite. The intermediate products investigation showed to some extent the phase transformation of calcium carbonate in its growing process from metastable vaterite to calcite and indicated that the calcium carbonate crystal growth in HEC solutions occurs through dissolution and reprecipitation process. Calcium carbonate growth in both presence of HEC and ethanol or Mg 2+ was also examined. This work demonstrates the potential of water soluble cellulose ethers in controlling biominerals crystallization and growth. The results are revelatory for biomineralization and fabricating new organic-inorganic hybrids based on cellulose derivatives.

Cost-utility and budget impact analyses of the use of NEPA for chemotherapy-induced nausea and vomiting prophylaxis in Italy.

Science.gov (United States)

Restelli, Umberto; Saibene, Gabriella; Nardulli, Patrizia; Di Turi, Roberta; Bonizzoni, Erminio; Scolari, Francesca; Perrone, Tania; Croce, Davide; Celio, Luigi

2017-08-01

To evaluate the efficiency of resources allocation and sustainability of the use of netupitant+palonosetron (NEPA) for chemotherapy-induced nausea and vomiting (CINV) prophylaxis assuming the Italian National Health Service (NHS) perspective. A published Markov model was adapted to assess the incremental cost-utility ratio of NEPA compared with aprepitant (APR) + palonosetron (PALO), fosaprepitant (fAPR) + PALO, APR + ondansetron (ONDA), fAPR + ONDA in patients receiving a highly emetogenic chemotherapy (HEC) and with APR + PALO and fAPR + PALO in patients receiving a moderately emetogenic chemotherapy (MEC). Oncology hospital department in Italy. A Markov model was used to determine the impact of NEPA on the budget of the Italian NHS on a 5-day time horizon, corresponding to the acute and delayed CINV prophylaxis phases. Direct medical costs considered were related to antiemetic drugs, adverse events management, CINV episodes management. Clinical and quality of life data referred to previously published works. The budget impact analysis considered the aforementioned therapies plus PALO alone (for HEC and MEC) on a 5-year time horizon, comparing two scenarios: one considering the use of NEPA and one not considering its use. Incremental cost per quality adjusted life year (QALY) and differential economic impact for the Italian NHS between the two scenarios considered. NEPA is more effective and less expensive (dominant) compared with APR + PALO (for HEC and MEC), fAPR + PALO (for HEC and MEC), APR + ONDA (for HEC), fAPR + ONDA (for HEC). The use of NEPA would lead to a 5-year cost decrease of €63.7 million (€42.7 million for HEC and €20.9 million for MEC). NEPA allows an efficient allocation of resources for the Italian NHS and it is sustainable, leading to a cost decrease compared with a scenario which does not consider its use. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No

Does Homeownership Counseling Affect the Prepayment and Default Behavior of Affordable Mortgage Borrowers?

Science.gov (United States)

Quercia, Roberto; Spader, Jonathan

2008-01-01

The lack of industry wide data on homeownership education and counseling (HEC) programs has severely limited evaluation. In particular, very little evidence exists on the relationship between HEC completion and loan prepayment, an outcome of interest to both mortgage lenders and consumer advocates. Where mortgage prepayment directly influences the…

Hydraulic Characteristics of Bedrock Constrictions and Evaluation of One- and Two-Dimensional Models of Flood Flow on the Big Lost River at the Idaho National Engineering and Environmental Laboratory, Idaho

Science.gov (United States)

Berenbrock, Charles; Rousseau, Joseph P.; Twining, Brian V.

2007-01-01

A 1.9-mile reach of the Big Lost River, between the Idaho National Engineering and Environmental Laboratory (INEEL) diversion dam and the Pioneer diversion structures, was investigated to evaluate the effects of streambed erosion and bedrock constrictions on model predictions of water-surface elevations. Two one-dimensional (1-D) models, a fixed-bed surface-water flow model (HEC-RAS) and a movable-bed surface-water flow and sediment-transport model (HEC-6), were used to evaluate these effects. The results of these models were compared to the results of a two-dimensional (2-D) fixed-bed model [Transient Inundation 2-Dimensional (TRIM2D)] that had previously been used to predict water-surface elevations for peak flows with sufficient stage and stream power to erode floodplain terrain features (Holocene inset terraces referred to as BLR#6 and BLR#8) dated at 300 to 500 years old, and an unmodified Pleistocene surface (referred to as the saddle area) dated at 10,000 years old; and to extend the period of record at the Big Lost River streamflow-gaging station near Arco for flood-frequency analyses. The extended record was used to estimate the magnitude of the 100-year flood and the magnitude of floods with return periods as long as 10,000 years. In most cases, the fixed-bed TRIM2D model simulated higher water-surface elevations, shallower flow depths, higher flow velocities, and higher stream powers than the fixed-bed HEC-RAS and movable-bed HEC-6 models for the same peak flows. The HEC-RAS model required flow increases of 83 percent [100 to 183 cubic meters per second (m3/s)], and 45 percent (100 to 145 m3/s) to match TRIM2D simulations of water-surface elevations at two paleoindicator sites that were used to determine peak flows (100 m3/s) with an estimated return period of 300 to 500 years; and an increase of 13 percent (150 to 169 m3/s) to match TRIM2D water-surface elevations at the saddle area that was used to establish the peak flow (150 m3/s) of a paleoflood

Lysophosphatidic acid (LPA) effects on endometrial carcinoma in vitro proliferation, invasion, and matrix metalloproteinase activity.

Science.gov (United States)

Wang, Feng-qiang; Ariztia, Edgardo V; Boyd, Leslie R; Horton, Faith R; Smicun, Yoel; Hetherington, Jessica A; Smith, Phillip J; Fishman, David A

2010-04-01

Lysophosphatidic acid (LPA) has potent growth-regulatory effect in many cell types and has been linked to the in vivo tumor growth and metastasis in several malignancies. The goal of this study was to assess the regulation of (EC) microenvironment by LPA through the examination of its effect on cell proliferation, migration, invasion, uPA activity, and matrix metalloproteinase (MMP) secretion/activation. All experiments were performed in vitro using an EC cell line, HEC-1A. Cell proliferation was determined using the Promega MTS proliferation assay following 48 h of exposures to different concentrations of LPA (0.1, 1.0 and 10.0 microM). Cell invasion was assessed using a modified Boyden chamber assay with collagen I coated on the membrane. HEC-1A motility was examined by Boyden chamber migration assay as well as the scratch wound closure assay on type I collagen. MMP secretion/activation in HEC-1A conditioned medium was detected by gelatin zymography. MMP-7 mRNA expression was determined using real-time PCR. uPA activity was measured using a coupled colorimetric assay. LPA, at the concentrations of 0.1 and 1.0 microM, significantly induced the proliferation of HEC-1A cells (p0.05). Gelatin zymogram showed that HEC-1A cells secreted high levels of MMP-7, while MMP-2 and MMP-9 are barely detectable. In addition, LPA significantly enhanced uPA activity in HEC-1A conditioned medium in a concentration-dependent manner. LPA is a potent modulator of cellular proliferation and invasion for EC cells. It also has the capacity to stimulate the secretion/activity of uPA and MMP-7. Those results suggest that LPA is a bioactive modulator of EC microenvironment and may have a distinct regulation mechanism as observed in epithelial ovarian cancer. Copyright 2009. Published by Elsevier Inc.

Effects of tides on the hydrology and geometry of a freshwater channel

African Journals Online (AJOL)

The computer program such as HEC-HMS 2.2.2 will be used to carry out the Hydrologic Model Calibration. By using HEC-RAS, Hydraulic Model Calibration will be carried out for the channel. The discharge with different ARI will be used as the upstream boundary condition during the flow analysis. Frequency analysis for ...

First Wheel of the Hadronic EndCap Calorimeter Completed

CERN Multimedia

Oram, C.J.

2002-01-01

With the LAr calorimeters well advanced in module production, the attention is turning to Batiment 180 where the calorimeter modules are formed into complete detectors and inserted into their respective cryostats. For the Hadronic End Cap (HEC) Group the task in B180 is to assemble the wheels, rotate them into their final orientation, and put them onto the cradle in front of the End Cap Cryostat. These tasks have been completed for the first HEC wheel in the B180 End Cap Clean Room. Given that this wheel weighs 70 tons the group is very relieved to have established that these gymnastics with the wheel proceed in a routine fashion. To assemble a wheel we take modules that have already been cold tested, do the final electrical testing and locate them onto the HEC wheel assembly table. Four wheels are required in total, each consisting of 32 modules. Wheel assembly is done in the horizontal position, creating a doughnut-like object sitting on the HEC table. The first picture shows the last module being added ...

Impact of 5-HT(3) RA selection within triple antiemetic regimens on uncontrolled highly emetogenic chemotherapy-induced nausea/vomiting.

Science.gov (United States)

Schwartzberg, Lee; Jackson, James; Jain, Gagan; Balu, Sanjeev; Buchner, Deborah

2011-08-01

It is recommended that patients initiate triple antiemetic therapy with one of the 5-hydroxytryptamine receptor antagonists (5-HT(3) RAs), aprepitant (or its intravenous prodrug fosaprepitant) and dexamethasone prior to the start of highly emetogenic chemotherapy (HEC). However, the impact of 5-HT(3) RA selection within triple antiemetic regimens on the risk of uncontrolled chemotherapy-induced nausea and vomiting (CINV) with HEC has not been well studied. To assess the likelihood of an uncontrolled CINV event following antiemetic prophylaxis with the 5-HT(3) RA palonosetron + aprepitant/fosaprepitant + dexamethasone (palonosetron cohort) versus any of the other 5-HT(3) RAs + aprepitant/fosaprepitant + dexamethasone (other 5-HT(3) RA cohort) among single-day HEC cycles. Single-day HEC cycles (a gap of at least 5 days between two administrations) among patients with a cancer diagnosis and receiving antiemetic prophylaxis with the aforementioned regimens between 1/1/2006 and 6/30/2010 were identified from the IMS LifeLink claims database. Uncontrolled CINV events were identified through ICD-9-CM codes (nausea and vomiting), Current Procedural Terminology codes (hydration), rescue medications and/or use of antiemetic therapy from days 2-5 following HEC administration. Risks for an uncontrolled CINV event among all patients, and within breast cancer and multiple cancer subpopulations, were analyzed at cycle level using logistic multivariate regression models. A total of 8018 cycles for the palonosetron cohort and 1926 cycles for the other 5-HT(3) RA cohort (3574 and 978 patients, respectively) were analyzed. Single-day HEC cycles received by the palonosetron cohort had a significantly lower unadjusted risk of an uncontrolled CINV event (17.5 vs 20.7% for the other 5-HT(3) RA cohort; p = 0.0010), with a 17% lower adjusted risk for palonosetron-administered cycles (odds ratio: 0.83; 95% CI: 0.73-0.94; p = 0.0042). Results in the breast cancer and multiple cancer

The impact of 5-hydroxytryptamine-receptor antagonists on chemotherapy treatment adherence, treatment delay, and nausea and vomiting

Directory of Open Access Journals (Sweden)

Palli SR

2015-06-01

Full Text Available Swetha Rao Palli,1 Michael Grabner,1 Ralph A Quimbo,1 Hope S Rugo2 1HealthCore, Wilmington, DE, 2University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA Purpose: To determine the incidence of chemotherapy-induced nausea/vomiting (CINV and chemotherapy treatment delay and adherence among patients receiving palonosetron versus other 5-hydroxytryptamine receptor antagonist (5-HT3 RA antiemetics. Materials and methods: This retrospective claims analysis included adults with primary malignancies who initiated treatment consisting of single-day intravenous highly emetogenic chemotherapy (HEC or moderately EC (MEC regimens. Treatment delay was defined as a gap in treatment at least twice the National Comprehensive Cancer Network-specified cycle length, specific to each chemotherapy regimen. Treatment adherence was determined by the percentage of patients who received the regimen-specific recommended number of chemotherapy cycles within the recommended time frame. Results: We identified 1,832 palonosetron and 2,387 other 5-HT3 RA (“other” patients who initiated HEC therapy, and 1,350 palonosetron users and 1,379 patients on other antiemetics who initiated MEC therapy. Fewer patients receiving palonosetron experienced CINV versus other (HEC, 27.5% versus 32.2%, P=0.0011; MEC, 36.1% versus 41.7%, P=0.0026, and fewer treatment delays occurred among patients receiving palonosetron versus other (HEC, 3.2% versus 6.0%, P<0.0001; MEC, 17.0% versus 26.8%, P<0.0001. Compared with the other cohort, patients receiving palonosetron were significantly more adherent to the index chemotherapy regimen with respect to the recommended time frame (HEC, 74.7% versus 69.7%, P=0.0004; MEC, 43.1% versus 37.3%, P=0.0019 and dosage (HEC, 27.3% versus 25.8%, P=0.0004; MEC, 15.0% versus 12.6%, P=0.0019. Conclusion: Palonosetron more effectively reduced occurrence of CINV in patients receiving HEC or MEC compared with

Final Report on Geoscience Center Research

Science.gov (United States)

1992-11-01

utilizes the capabilities of AutoCAD version 9 and three AutoLISP programs: BASINS, PLANES and CHANNELS, to extract, organize and display watershed data...capabilities of AutoCAD rainfall-runoff simulation and an example application version 9 and three programs, BASINS, PLANES, and CHAN- to Macks Creek...the program CN to calculate some HEC-1 parameter values, machine, a True Grid 8017 digitizing tablet, AutoCAD Phase I utilizes the program HECUPDATE to

Effects of dexamethasone-21-isonicotinate on peripheral insulin action in dairy cows 5 days after surgical correction of abomasal displacement.

Science.gov (United States)

Kusenda, M; Kaske, M; Piechotta, M; Locher, L; Starke, A; Huber, K; Rehage, J

2013-01-01

Dexamethasone frequently is used for treatment of ketosis in dairy cows, but its effects are not fully understood. Dexamethasone treatment affects whole body insulin sensitivity. Twelve German Holstein cows, 2-4 weeks postpartum, 5 days after omentopexy to correct left abomasal displacement. Randomized, blinded, case-control study. Treatment with dexamethasone-21-isonicotinate (DG; 40 μg/kg IM; n = 6) or saline (control group [CG], 15 mL IM, n = 6) on day 0 (d0). Blood samples were obtained before (d0) and after treatment (d1 and d2), and analyzed for glucose, insulin, and nonesterified fatty acid (NEFA) concentrations. Hepatic triglycerides (TAG) were measured in liver samples taken on d0 and d2. Five consecutive hyperinsulinemic-euglycemic clamps (HEC-I-V; insulin dosages: 0.1, 0.5, 2, 5, 10 mU/kg/min, respectively) were performed on d1 and steady state glucose infusion rate (SSGIR), insulin concentration (SSIC), insulin sensitivity index (ISI = SSGIR/SSIC), and plasma NEFA concentration (SSNEFA) were assessed. Compared with CG-cows, DG-cows on d1 had higher plasma glucose (P = .004) and insulin (P insulin-stimulated decrease in SSNEFA (HEC-II, P = .006; HEC-III, P = .01; HEC-IV, P = .003; HEC-V, P = .011). Decrease in hepatic TAG content in DG-cows was higher compared with CG-cows (P insulin sensitivity and affects glucose and lipid metabolism in early lactating dairy cows. Copyright © 2012 by the American College of Veterinary Internal Medicine.

Initial field test of High-Energy Corona process for treating a contaminated soil-offgas stream

International Nuclear Information System (INIS)

Shah, R.R.; Garcia, R.E.; Jeffs, J.T.; Virden, J.W.; Heath, W.O.

1995-04-01

The High-Energy Corona (HEC) technology for treating process offgases has been under development at Pacific Northwest Laboratory (PNL) since 1991. The HEC process uses high-voltage electrical discharges in air to ionize the air, forming a low-temperature plasma that would be expected to destroy a wide variety of organic compounds in air. The plasma contains strong oxidants, possibly including hydroxyl radicals, hydroperoxy radicals, superoxide radicals, various excited as well as ionized forms of oxygen, high-energy electrons, and ultraviolet (UV) light. Because the high-voltage plasma is produced near ambient temperatures and pressures, yet exhibits extremely rapid destruction kinetics with relatively low power requirements, the HEC technique appears promising as a low-cost treatment technique (Virden et al. 1992). As part of the Volatile Organic Compound (VOC) Nonarid Integrated Demonstration (ID) at the DOE Savannah River Site, research activities were initiated in December 1991 to develop a prototype HEC process for a small-scale field demonstration to treat a soil-offgas stream contaminated with trichloroethylene (TCE) and perchloroethylene (PCE) at varying concentrations. Over an 18-month period, the HEC technology was developed on a fast track, through bench and pilot scales into a trailer-mounted system that was tested at the Nonarid ID. Other national laboratories, universities, and private companies have also participated at the Nonarid ID to demonstrate a number of conventional, emerging and innovative approaches for treating the same soil-offgas stream

Development of curcumin-loaded poly(hydroxybutyrate- co-hydroxyvalerate) nanoparticles as anti-inflammatory carriers to human-activated endothelial cells

Science.gov (United States)

Simion, Viorel; Stan, Daniela; Gan, Ana-Maria; Pirvulescu, Monica Madalina; Butoi, Elena; Manduteanu, Ileana; Deleanu, Mariana; Andrei, Eugen; Durdureanu-Angheluta, Anamaria; Bota, Marian; Enachescu, Marius; Calin, Manuela; Simionescu, Maya

2013-12-01

Curcumin (Cm)-loaded poly(hydroxybutyrate- co-hydroxyvalerate) (PHBV) nanoparticles (CmPN) were obtained and characterized and their effect on human endothelial cells (HEC) was assessed. Different CmPN formulations have been prepared using the emulsion solvent evaporation technique, and characterized for size, structure, Zeta potential, Cm entrapment efficiency, and in vitro Cm release. CmPN cytotoxicity and cellular uptake have been followed using HEC. Also, the effect of CmPN treatment on the p38MAPK signaling pathway in endothelial cells was investigated. The results obtained by electron and atomic force microscopy revealed the spherical shape of the CmPN formulation. Based on size and encapsulation efficiency, the CmPN formulation with the average diameter of 186 nm and with the highest encapsulation efficiency (83 %) has been used in the further studies. The release of Cm from CmPN was 18 % after 8 h of incubation at 37 °C, followed by a slow release until 144 h, when it reached 44 %, indicating a controlled release. CmPN are taken up by HEC and exhibited low cytotoxicity at concentrations up to 10 μM. The pre-treatment of HEC with CmPN before exposure to tumor necrosis factor-alpha (TNF-α) determined a decrease of p38MAPK phosphorylation. In conclusion, Cm encapsulated into PHBV nanoparticles, at concentration up to 10 μM, has low cytotoxicity and display anti-inflammatory activity on TNF-α-activated HEC by suppressing the phosphorylation of p38MAPK.

Flood plain analysis for Petris, , Troas, and Monoros, tia watersheds, the Arad department, Romania

Science.gov (United States)

Győri, M.-M.; Haidu, I.

2012-04-01

The present study sets out to determine the flood plains corresponding to flood discharges having 10, 50 and 100 year recurrence intervals on the Monoroštia, Petriš and Troaš Rivers, located in Western Romania, the Arad department. The data of the study area is first collected and pre-processed in ArcGIS. It consists of land use data, soil data, the DEM, stream gauges' and meteorological stations' locations, on the basis of which the watersheds' hydrologic parameters' are computed using the Geospatial Hydrologic Modelling Extension (HEC Geo-HMS). HEC Geo-HMS functions as an interface between ArcGIS and HEC-HMS (Hydrologic Engineering Centre- Hydrologic Modelling System) and converts the data collected and generated in ArcGIS to data useable by HEC-HMS. The basin model component in HEC-HMS represents the physical watershed. It facilitates the effective rainfall computation on the basis of the input hyetograph, passing the results to a transform function that converts the excess precipitation into runoff at the subwatersheds' outlet. This enables the estimation and creation of hydrographs for the ungauged watersheds. In the present study, the results are achieved through the SCS CN loss method and the SCS Unit hydrograph transform method. The simulations use rainfall data that is registered at the stations situated in the catchments' vicinity, data that spans over two decades (1989-2009) and which allows the rainfall hyetographs to be determined for the above mentioned return periods. The model will be calibrated against measured streamflow data from the gauging stations on the main rivers, leading to the adjustment of watershed parameters, such as the CN parameter. As the flood discharges for 10, 50 and 100 year return periods have been determined, the profile of the water surface elevation along the channel will be computed through a steady flow analysis, with HEC-RAS (Hydrologic Engineering Centre- River Analysis System). For each of the flood frequencies, a

Identification of Challenges and Opportunities for Regional Sediment Management (RSM) and Engineering with Nature (EWN) within Inland USACE Districts

Science.gov (United States)

2016-07-01

HEC numerical modeling and data collection capabilities, and sediment challenges in river and reservoir systems. In addition to the presentations, much...the sediment impact analysis methods (SIAM) in HEC - RAS . In Proceedings, Eighth Joint Federal Interagency Sedimentation Conference. Reno, NV...partnerships, (b) identify both challenges and opportunities in incorporating RSM and EWN into inland river , reservoir, and watershed systems, and (c

Conservation Reserve Program effects on floodplain land cover management.

Science.gov (United States)

Jobe, Addison; Kalra, Ajay; Ibendahl, Elise

2018-05-15

Growing populations and industrialized agriculture practices have eradicated much of the United States wetlands along river floodplains. One program available for the restoration of floodplains is the Conservation Reserve Program (CRP). The current research explores the effects CRP land change has on flooding zones, utilizing Flood Modeller and HEC-RAS. Flood Modeller is proven a viable tool for flood modeling within the United States when compared to HEC-RAS. Application of the software is used in the Nodaway River system located in the western halves of Iowa and Missouri to model effects of introducing new forest areas within the region. Flood stage during the conversion first decreases in the early years, before rising to produce greater heights. Flow velocities where CRP land is present are reduced for long-term scopes. Velocity reduction occurs as the Manning's roughness increases due to tree diameter and brush density. Flood zones become more widespread with the implementation of CRP. Future model implementations are recommended to witness the effects of smaller flood recurrence intervals. Copyright © 2018 Elsevier Ltd. All rights reserved.

Community-based human-elephant conflict mitigation: The value of an evidence-based approach in promoting the uptake of effective methods.

Directory of Open Access Journals (Sweden)

Donny Gunaryadi

Full Text Available Human-elephant conflict (HEC is a serious threat to elephants and can cause major economic losses. It is widely accepted that reduction of HEC will often require community-based methods for repelling elephants but there are few tests of such methods. We tested community-based crop-guarding methods with and without novel chili-based elephant deterrents and describe changes in farmers' willingness to adopt these methods following our demonstration of their relative effectiveness. In three separate field-trials that took place over almost two years (October 2005 -May 2007 in two villages adjacent to Way Kambas National Park (WKNP in Indonesia, we found that community-based crop-guarding was effective at keeping Asian elephants (Elephas maximus out of crop fields in 91.2% (52 out of 57, 87.6% (156 out of 178, and 80.0% (16 out of 20 of attempted raids. Once the method had been shown to be effective at demonstration sites, farmers in 16 villages around WKNP voluntarily adopted it during the July 2008 to March 2009 period and were able to repel elephants in 73.9% (150 out of 203 of attempted raids, with seven villages repelling 100% of attempted raids. These 16 villages had all experienced high levels of HEC in the preceding years; e.g. they accounted for >97% of the 742 HEC incidents recorded for the entire park in 2006. Our work shows, therefore, that a simple evidence-based approach can facilitate significant reductions in HEC at the protected area scale.

Advanced airway management in hoist and longline operations in mountain HEMS - considerations in austere environments: a narrative review This review is endorsed by the International Commission for Mountain Emergency Medicine (ICAR MEDCOM).

Science.gov (United States)

Pietsch, Urs; Knapp, Jürgen; Kreuzer, Oliver; Ney, Ludwig; Strapazzon, Giacomo; Lischke, Volker; Albrecht, Roland; Phillips, Patrick; Rauch, Simon

2018-04-03

Providing sufficient oxygenation and ventilation is of paramount importance for the survival of emergency patients. Therefore, advanced airway management is one of the core tasks for every rescue team. Endotracheal intubation is the gold standard to secure the airway in the prehospital setting. This review aims to highlight special considerations for advanced airway management preceding human external cargo (HEC) evacuations. We systematically searched MEDLINE, EMBASE, and PubMed in August 2017 for articles on airway management and ventilation in patients before hoist or longline operation in HEMS. Relevant reference lists were hand-searched. Three articles with regard to advanced airway management and five articles concerning the epidemiology of advanced airway management in hoist or longline rescue missions were included. We found one case report regarding ventilation during hoist operations. The exact incidence of advanced airway management before evacuation of a patient by HEC is unknown but seems to be very low (< 5%). There are several hazards which can impede mechanical ventilation of patients during HEC extractions: loss of equipment, hyperventilation, inability to ventilate and consequent hypoxia, as well as inadequacy of monitoring. Advanced airway management prior to HEC operation is rarely performed. If intubation before helicopter hoist operations (HHO) and human cargo sling (HCS) extraction is considered by the rescue team, a risk/benefit analysis should be performed and a clear standard operating procedure (SOP) should be defined. Continuous and rigorous training including the whole crew is required. An international registry on airway management during HEC extraction would be desirable.

Efficacy and safety of rolapitant for prevention of chemotherapy-induced nausea and vomiting over multiple cycles of moderately or highly emetogenic chemotherapy.

Science.gov (United States)

Rapoport, Bernardo; Schwartzberg, Lee; Chasen, Martin; Powers, Dan; Arora, Sujata; Navari, Rudolph; Schnadig, Ian

2016-04-01

Rolapitant, a novel neurokinin-1 receptor antagonist (RA), was shown to protect against delayed chemotherapy-induced nausea and vomiting (CINV) during the first cycle of moderately emetogenic chemotherapy (MEC) or highly emetogenic chemotherapy (HEC) in randomized, double-blind trials. This analysis explored the efficacy and safety of rolapitant in preventing CINV over multiple cycles of MEC or HEC. Patients in one phase III MEC, one phase II HEC, and two phase III HEC clinical trials were randomized to receive oral rolapitant (180 mg) or placebo in combination with a 5-hydroxytryptamine type 3 RA and dexamethasone. Regardless of response in cycle 1, patients could continue the same antiemetic treatment for up to six cycles. On days 6-8 of each subsequent chemotherapy cycle, patients reported the incidence of emesis and/or nausea interfering with normal daily life. Post hoc analyses of pooled safety and efficacy data from the four trials were performed for cycles 2-6. Significantly more patients receiving rolapitant than control reported no emesis or interfering nausea (combined measure) in cycles 2 (p = 0.006), 3 (p cycles 1-6, time-to-first emesis was significantly longer with rolapitant than with control (p cycles 2-6 was similar in rolapitant (5.5%) and control (6.8%) arms. No cumulative toxicity was observed. Over multiple cycles of MEC or HEC, rolapitant provided superior CINV protection and reduced emesis and nausea interfering with daily life compared with control and remained well tolerated. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Caffeic acid attenuates the inflammatory stress induced by glycated LDL in human endothelial cells by mechanisms involving inhibition of AGE-receptor, oxidative, and endoplasmic reticulum stress.

Science.gov (United States)

Toma, Laura; Sanda, Gabriela M; Niculescu, Loredan S; Deleanu, Mariana; Stancu, Camelia S; Sima, Anca V

2017-09-10

Type 2 diabetes mellitus is a worldwide epidemic and its atherosclerotic complications determine the high morbidity and mortality of diabetic patients. Caffeic acid (CAF), a phenolic acid present in normal diets, is known for its antioxidant properties. The aim of this study was to investigate CAF's anti-inflammatory properties and its mechanism of action, using cultured human endothelial cells (HEC) incubated with glycated low-density lipoproteins (gLDL). Levels of the receptor for advanced glycation end-products (RAGE), inflammatory stress markers (C reactive protein, CRP; vascular cell adhesion molecule-1, VCAM-1; monocyte chemoattractant protein-1, MCP-1), and oxidative stress and endoplasmic reticulum stress (ERS) markers were evaluated in gLDL-exposed HEC, in the presence/absence of CAF. RAGE silencing or blocking, specific inhibitors for oxidative stress (apocynin, N-acetyl-cysteine), and ERS (salubrinal) were used. The results showed that: (i) gLDL induced CRP synthesis and secretion through mechanisms involving NADPH oxidase-dependent oxidative stress and ERS in HEC; (ii) gLDL-RAGE interaction, oxidative stress, and ERS stimulated the secretion of VCAM-1 and MCP-1 in HEC; and (iii) CAF reduced the secretion of CRP, VCAM-1, and MCP-1 in gLDL-exposed HEC by inhibiting RAGE expression, oxidative stress, and ERS. In conclusion, CAF might be a promising alternative to ameliorate a wide spectrum of disorders due to its complex mechanisms of action resulting in anti-inflammatory and antioxidative properties. © 2017 BioFactors, 43(5):685-697, 2017. © 2017 International Union of Biochemistry and Molecular Biology.

Final report Hanford environmental compliance project 89-D-172

International Nuclear Information System (INIS)

Kelly, J.R.

1996-01-01

The Hanford Environmental Compliance (HEC) Project is unique in that it consisted of 14 subprojects which varied in project scope and were funded from more that one program. This report describes the HEC Project from inception to completion and the scope, schedule, and cost of the individual subprojects. Also provided are the individual subproject Cost closing statements and Project completion reports accompanied by construction photographs and illustrations

Hormonal and epigenetic regulation during embryogenic tissue habituation in Cucurbita pepo L.

Science.gov (United States)

Leljak-Levanić, Dunja; Mrvková, Mihaela; Turečková, Veronika; Pěnčík, Aleš; Rolčík, Jakub; Strnad, Miroslav; Mihaljević, Snježana

2016-01-01

Habituated embryogenic line of pumpkin contained more CKs and IAA, but less ABA than the non-habituated line. Pronounced hypomethylation correlated with the absence of 2,4-D, addition of 5-azaC, and the process of habituation. A comparative analysis between habituated and non-habituated embryogenic cultures of pumpkin (Cucurbita pepo L.) in relation to endogenous phytohormones, global DNA methylation, and developmental and regeneration capacities of the cultures was conducted. The analysis revealed more cytokinins (CKs) and indole-3-acetic acid (IAA), but less abscisic acid (ABA) in the habituated HEC line than in the non-habituated DEC line. Ribosides and ribotides were the most abundant CK forms in both HEC and DEC lines (75.9 and 57.6 %, respectively). HEC contained more free-base CKs (5.8 vs. 3.2 %), whereas DEC contained considerably more O-glycosides (39.1 vs. 18.3 %). Although prevalence of IAA was common for both lines, relative ratio of CKs and ABA differed between DEC and HEC lines. ABA was prevailing over CKs in DEC, while CKs prevailed over ABA in HEC line. Taking into account the importance of ABA for embryo maturation, the reduced endogenous ABA content in HEC line might be the reason for a 5-fold reduction in regeneration capacity compared to DEC. Both habituated and non-habituated embryogenic lines were highly methylated in the presence of 2,4-dichlorophenoxyacetic acid (2,4-D). Pronounced hypomethylation correlated with the absence of 2,4-D, addition of 5-azacytidine (5-azaC), but also with the process of habituation. The habituated line was resistant to the effect of hypomethylation drug 5-azaC and remained highly methylated even after the addition of 5-azaC. Also, 5-azaC did not change the developmental pattern in the habituated line, indicating the existence of separate mechanisms by which 2,4-D influences global DNA methylation in comparison to habituation-related global DNA methylation.

Environmental management in the Hydro-Electric Commission

International Nuclear Information System (INIS)

Scanlon, A.

1995-01-01

The Tasmanian Hydro Electric Commission (HEC) is a large and diverse organization, providing electricity generation, transmission, distribution and retail services throughout Tasmania. It is a significant manager of Tasmania's land and water resources and, as a consequence, has important environmental responsibilities. This paper outlines the background to conflict with the environmental movement over power generation development projects in south western Tasmania and the development of an environmental policy. As part of the environmental policy, the HEC has prepared environmental reviews, audits and risk assessment and is currently developing and implementing a comprehensive environmental management system. The HEC sees the introduction of the environmental management system as demonstrating a commitment to continuing environmental improvement and in establishing itself as a Tasmanian and national leader in the area of environmental management. 1 tab., 2 figs., 4 refs

Physical Model Study of Cross Vanes and Ice

Science.gov (United States)

2009-08-01

spacing since, in the pre-scour state, experiments and the HEC - RAS hydraulic model (USACE 2002b) found that water surface ele- vation merged with the...docs/eng-manuals/em1110- 2-1612/toc.htm. USACE (2002b) HEC - RAS , Hydraulic Reference Manual. US Army Corps of Engineers Hydrologic Engineering Center...Currently little design guidance is available for constructing these structures on ice-affected rivers . This study used physical and numerical

Antiemetic therapy in Asia Pacific countries for patients receiving moderately and highly emetogenic chemotherapy--a descriptive analysis of practice patterns, antiemetic quality of care, and use of antiemetic guidelines.

Science.gov (United States)

Yu, Shiying; Burke, Thomas A; Chan, Alexandre; Kim, Hoon-Kyo; Hsieh, Ruey Kuen; Hu, Xichun; Liang, Jin-Tung; Baños, Ana; Spiteri, Carmel; Keefe, Dorothy M K

2015-01-01

This paper reports prescribing patterns for prophylaxis of chemotherapy-induced nausea and vomiting (CINV) after highly or moderately emetogenic chemotherapy (HEC or MEC) for cancer in six Asia Pacific countries. In a prospective noninterventional study, 31 sites in Australia, China, India, Singapore, South Korea, and Taiwan recorded details of CINV prophylaxis for the acute phase (first 24 h) and delayed phase (days 2-5) after single-day HEC or MEC for adult patients. Additional information on CINV prophylactic medications was collected from 6-day patient diaries. Primary antiemetic therapies were defined as corticosteroids, the 5-hydroxytryptamine-3 receptor antagonists (5HT3-RAs), and neurokinin-1 receptor antagonists (NK1-RAs). Evaluable patients in cycle 1 numbered 648 (318 [49%] HEC and 330 [51%] MEC) of mean (SD) age of 56 (12) years, including 58% women. For the acute phase after HEC, overall (and country range), 96% (91-100%) of patients received a 5HT3-RA, 87% (70-100%) a corticosteroid, and 43% (0-91%) an NK1-RA. CINV prophylaxis for the HEC delayed phase was more variable: including 22% (7-65%) 5HT3-RA, 52% (12-93%) corticosteroid, and 46% (0-88%) NK1-RA. For the MEC acute phase, 97% (87-100%) of patients received 5HT3-RA and 86% (73-97%) a corticosteroid. For the MEC delayed phase, 201 patients (61%) received a primary antiemetic, including 5HT3-RA (41%), corticosteroid (37%), and/or NK1-RA (4%). The 5HT3-RAs were prescribed consistently in all countries, while prescribing of other antiemetic therapies was variable, and corticosteroids were under-prescribed for CINV prophylaxis, particularly in the delayed phase.

Perbandingan Hasil Pemodelan Aliran Satu Dimensi Unsteady Flow dan Steady Flow pada Banjir Kota

Directory of Open Access Journals (Sweden)

Andreas Tigor Oktaga

2016-06-01

Full Text Available One dimensional flow is often used as a flood simulation for the planning capacity of the river. Flood is a type of unsteady non-uniform flow, that can be simulated using HEC-RAS. HEC-RAS software is often used for flood modeling with a one-dimensional flow method. Unsteady flow modeling results in HEC-RAS sometimes refer to error and warning due to unstable analysis program. The stability program among others influenced bend in the river flow, the steep slope of the river bottom, and changes in cross-section shape. Because the flood handling required maximum discharge and maximum flood water level, then a steady flow is often used as an alternative to simulate the flood flow. This study aimed to determine the advantages and disadvantages of modeling unsteady non-uniform and steady non-uniform flow. The research location in the Kanal Banjir Barat, in the Semarang City. Hydraulics modeling uses HEC-RAS 4.1 and for discharge the plan is obtained from the HEC-HMS 3.5. Results of the comparison modeling hydraulics the modeling of steady non-uniform flow has a tendency water level is higher and modeling of unsteady non-uniform flow takes longer to analyze. Results of the comparison the average flood water level maximun is less than 15%  (± 0,3 meters, that is 0.27 meters (13.16% for Q50, 0.25 meters (11.56% for Q100, dan 0.16 meters (4.73% for Q200. So the modeling steady non-uniform flow can still be used as a companion version the modeling unsteady non-uniform flow.

Prevention of chemotherapy-induced nausea: the role of neurokinin-1 (NK1) receptor antagonists.

Science.gov (United States)

Bošnjak, Snežana M; Gralla, Richard J; Schwartzberg, Lee

2017-05-01

Chemotherapy-induced nausea (CIN) has a significant negative impact on the quality of life of cancer patients. The use of 5-hydroxytryptamine-3 (5-HT 3 ) receptor antagonists (RAs) has reduced the risk of vomiting, but (except for palonosetron) their effect on nausea, especially delayed nausea, is limited. This article reviews the role of NK 1 RAs when combined with 5-HT 3 RA-dexamethasone in CIN prophylaxis. Aprepitant has not shown consistent superiority over a two-drug (ondansetron-dexamethasone) combination in nausea control after cisplatin- or anthracycline-cyclophosphamide (AC)-based highly emetogenic chemotherapy (HEC). Recently, dexamethasone and dexamethasone-metoclopramide were demonstrated to be non-inferior to aprepitant and aprepitant-dexamethasone, respectively, for the control of delayed nausea after HEC (AC/cisplatin), and are now recognized in the guidelines. The potential impact of the new NK 1 RAs rolapitant and netupitant (oral fixed combination with palonosetron, as NEPA) in CIN prophylaxis is discussed. While the clinical significance of the effect on nausea of the rolapitant-granisetron-dexamethasone combination after cisplatin is not conclusive, rolapitant addition showed no improvement in nausea prophylaxis after AC or moderately emetogenic chemotherapy (MEC). NEPA was superior to palonosetron in the control of nausea after HEC (AC/cisplatin). Moreover, the efficacy of NEPA in nausea control was maintained over multiple cycles of HEC/MEC. Recently, NK 1 RAs have been challenged by olanzapine, with olanzapine showing superior efficacy in nausea prevention after HEC. Fixed antiemetic combinations (such as NEPA) or new antiemetics with a long half-life that may be given once per chemotherapy cycle (rolapitant or NEPA) may improve patient compliance with antiemetic treatment.

[The Role of 5-Aza-CdR on Methylation of Promoter in RASSF1A Gene in Endometrial Carcinoma].

Science.gov (United States)

Huang, Li-ping; Chen, Chen; Wang, Xue-ping; Liu, Hui

2015-05-01

To explore the effect of demethylating drug 5-Aza-2'-deoxycytidine (5-Aza-CdR) on methtylation status of the Ras-association domain familylA gene (RASSF1A) in human endometrial carcinoma. Randomly'assign the human endometrial carcinoma cell line HEC-1-B into groups and use demethylating drug 5-Aza-CdR of different concentration to treat them. Then Methylation-specific polymerase chain reaction (MSP), real-time PCR, Western blot, TUNEL technology were used to analyze methylation status of RASSF1A promoter CpG islands, RASSF1A mRNA expression, RASSF1A protein expression and apoptosis of HEC-1-B cell. High DNA methylation in RASSF1A gene promoter region, low RASSF1A mRNA level and protein expression and out of control of human endometrial carcinoma cell HEC-1-B apoptosis were observed. 5-Aza-CdR of different concentration could reverse RASSF1A gene's methylation status, recover the expression of mRNA and protein, and control the growth of HEC-1-B by inducing apoptosis. Aberrant methylation of RASSF1A in endometrial cancer as a therapeutic target, demethylating agent 5-Aza-CdR could be an effective way of gene therapy.

APF530 (granisetron injection extended-release) in a three-drug regimen for delayed CINV in highly emetogenic chemotherapy.

Science.gov (United States)

Schnadig, Ian D; Agajanian, Richy; Dakhil, Christopher; Gabrail, Nashat Y; Smith, Robert E; Taylor, Charles; Wilks, Sharon T; Schwartzberg, Lee S; Cooper, William; Mosier, Michael C; Payne, J Yvette; Klepper, Michael J; Vacirca, Jeffrey L

2016-06-01

APF530, extended-release granisetron, provides sustained release for ≥5 days for acute- and delayed-phase chemotherapy-induced nausea and vomiting (CINV). We compared efficacy and safety of APF530 versus ondansetron for delayed CINV after highly emetogenic chemotherapy (HEC), following a guideline-recommended three-drug regimen. HEC patients received APF530 500 mg subcutaneously or ondansetron 0.15 mg/kg intravenously, with dexamethasone and fosaprepitant. Primary end point was delayed-phase complete response (no emesis or rescue medication). A higher percentage of APF530 versus ondansetron patients had delayed-phase complete response (p = 0.014). APF530 was generally well tolerated; treatment-emergent adverse event incidence was similar across arms, mostly mild-to-moderate injection-site reactions. APF530 versus the standard three-drug regimen provided superior control of delayed-phase CINV following HEC. ClinicalTrials.gov : NCT02106494.

PROJECT CASCADES OF SMALL DRY RESERVOIRS FOR FLOOD PROTECTION OF URBAN AREAS

OpenAIRE

Rafał Antoszewski; Katarzyna Jakubiec; Kinga Witek; Michał Domagała

2017-01-01

The paper presents the problem of designing an open reservoirs with a capacity of about 100 000 m3 in heavily urbanized areas of anthropogenically transformed natural watercourses with numerous outlets drainage and large sealed surfaces runoff. In particular the issues of the hydrological basics design based on the meteorological data in the catchment uncontrolled water level checkpoints with particular emphasis on the tools of computer-aided modeling of hydrological processes (HEC-HMS, HEC-...

An Assessment of Hydrology, Fluvial Geomorphology, and Stream Ecology in the Cardwell Branch Watershed, Nebraska, 2003-04

Science.gov (United States)

Rus, David L.; Dietsch, Benjamin J.; Woodward, Brenda K.; Fry, Beth E.; Wilson, Richard C.

2007-01-01

An assessment of the 16.3-square-mile Cardwell Branch watershed characterized the hydrology, fluvial geomorphology, and stream ecology in 2003-04. The study - performed by the U.S. Geological Survey in cooperation with the City of Lincoln, Nebraska, and the Lower Platte South Natural Resources District - focused on the 7.7-square-mile drainage downstream from Yankee Hill Reservoir. Hydrologic and hydraulic models were developed using the Hydrologic Modeling System (HEC-HMS) and River Analysis System (HEC-RAS) of the U.S. Army Corps of Engineers Hydraulic Engineering Center. Estimates of streamflow and water-surface elevation were simulated for 24-hour-duration design rainstorms ranging from a 50-percent frequency to a 0.2-percent frequency. An initial HEC-HMS model was developed using the standardized parameter estimation techniques associated with the Soil Conservation Service curve number technique. An adjusted HEC-HMS model also was developed in which parameters were adjusted in order for the model output to better correspond to peak streamflows estimated from regional regression equations. Comparisons of peak streamflow from the two HEC-HMS models indicate that the initial HEC-HMS model may better agree with the regional regression equations for higher frequency storms, and the adjusted HEC-HMS model may perform more closely to regional regression equations for larger, rarer events. However, a lack of observed streamflow data, coupled with conflicting results from regional regression equations and local high-water marks, introduced considerable uncertainty into the model simulations. Using the HEC-RAS model to estimate water-surface elevations associated with the peak streamflow, the adjusted HEC-HMS model produced average increases in water-surface elevation of 0.2, 1.1, and 1.4 feet for the 50-, 1-, and 0.2-percent-frequency rainstorms, respectively, when compared to the initial HEC-HMS model. Cross-sectional surveys and field assessments conducted between

Comparison of Spatial Interpolation Schemes for Rainfall Data and Application in Hydrological Modeling

Directory of Open Access Journals (Sweden)

Tao Chen

2017-05-01

Full Text Available The spatial distribution of precipitation is an important aspect of water-related research. The use of different interpolation schemes in the same catchment may cause large differences and deviations from the actual spatial distribution of rainfall. Our study analyzes different methods of spatial rainfall interpolation at annual, daily, and hourly time scales to provide a comprehensive evaluation. An improved regression-based scheme is proposed using principal component regression with residual correction (PCRR and is compared with inverse distance weighting (IDW and multiple linear regression (MLR interpolation methods. In this study, the meso-scale catchment of the Fuhe River in southeastern China was selected as a typical region. Furthermore, a hydrological model HEC-HMS was used to calculate streamflow and to evaluate the impact of rainfall interpolation methods on the results of the hydrological model. Results show that the PCRR method performed better than the other methods tested in the study and can effectively eliminate the interpolation anomalies caused by terrain differences between observation points and surrounding areas. Simulated streamflow showed different characteristics based on the mean, maximum, minimum, and peak flows. The results simulated by PCRR exhibited the lowest streamflow error and highest correlation with measured values at the daily time scale. The application of the PCRR method is found to be promising because it considers multicollinearity among variables.

Controlled release of diclofenac sodium through acrylamide grafted hydroxyethyl cellulose and sodium alginate.

Science.gov (United States)

Al-Kahtani, Ahmed A; Sherigara, B S

2014-04-15

To reinforce the hydroxyethyl cellulose for using it in biomedical and pharmaceutical applications as a drug delivery systems, the grafting of acrylamide onto hydroxyethyl cellulose (AAm-g-HEC) was achieved by Ce(IV) induced free radical polymerization. The AAm-g-HEC was then blended with sodium alginate (NaAlg) to prepare pH-sensitive interpenetrating network (IPN) microspheres (MPs) by emulsion-crosslinking method using glutaraldehyde (GA) as a crosslinking agent. The produced MPs are almost spherical in nature with smooth surfaces. Diclofenac sodium (DS), an anti-inflammatory drug, was successfully encapsulated into the MPs. The % encapsulation efficiency was found to vary between 54 and 67. The MPs were characterized by DSC, SEM and FTIR spectroscopy. In vitro release studies were carried out in simulated gastric fluid of pH 1.2 for 2h followed by simulated intestinal fluid of pH 7.4 at 37°C. The release data have been fitted to an empirical equation to investigate the diffusional exponent (n), which indicated that the release mechanism shifted from anomalous to the super Case-II transport. Copyright © 2014 Elsevier Ltd. All rights reserved.

ANALYSIS OF THE POSSIBILITY OF USING HYDROLOGICAL MODELS IN STRATEGIC ENVIRONMENTAL ASSESSMENT OF LOCAL SPATIAL DEVELOPMENT PLANS

OpenAIRE

Mariusz Sojka; Sadżide Murat-Błażejewska; Rafał Wróżyński

2014-01-01

The paper presents the possibility of application of the hydrological model HEC-HMS in the development of a strategic environmental assessment of local spatial development plans on surface water. The practical possibility of using simulation models of catchment response to high intensity precipitation is shown on the example of the Różany Potok watercourse catchment which is subject to rapid urbanization process. The area of Różany Potok catchment is 8.1 km2 and a stream length is 5.57 km. In...

Performance of the ATLAS hadronic end-cap calorimeter in beam tests

International Nuclear Information System (INIS)

Dowler, B.; Pinfold, J.; Soukup, J.; Vincter, M.; Cheplakov, A.; Datskov, V.; Fedorov, A.; Javadov, N.; Kalinnikov, V.; Kakurin, S.; Kazarinov, M.; Kukhtin, V.; Ladygin, E.; Lazarev, A.; Neganov, A.; Pisarev, I.; Serochkin, E.; Shilov, S.; Shalyugin, A.; Usov, Yu.; Ban, J.; Bruncko, D.; Chytracek, R.; Jusko, A.; Kladiva, E.; Strizenec, P.; Gaertner, V.; Hiebel, S.; Hohlfeld, M.; Jakobs, K.; Koepke, L.; Marschalkowski, E.; Meder, D.; Othegraven, R.; Schaefer, U.; Thomas, J.; Walkowiak, W.; Zeitnitz, C.; Leroy, C.; Mazini, R.; Mehdiyev, R.; Akimov, A.; Blagov, M.; Komar, A.; Snesarev, A.; Speransky, M.; Sulin, V.; Yakimenko, M.; Aderholz, M.; Brettel, H.; Cwienk, W.; Dulny, B.; Fent, J.; Fischer, A.; Haberer, W.; Huber, J.; Huber, R.; Karev, A.; Kiryunin, A.; Kobler, T.; Kurchaninov, L.; Laskus, H.; Lindenmayer, M.; Mooshofer, P.; Oberlack, H.; Salihagic, D.; Schacht, P.; Stenzel, H.; Striegel, D.; Tribanek, W.; Chekulaev, S.; Denisov, S.; Levitsky, M.; Minaenko, A.; Mitrofanov, G.; Moiseev, A.; Pleskatch, A.; Sytnik, V.; Benoit, P.; Hoyle, K.W.; Honma, A.; Maharaj, R.; Oram, C.J.; Pattyn, E.W.; Rosvick, M.; Sbarra, C.; Wellisch, H-P.; Wielers, M.; Birney, P.S.; Dobbs, M.; Fincke-Keeler, M.; Fortin, D.; Hodges, T.A.; Keeler, R.K.; Langstaff, R.; Lefebvre, M.; Lenckowski, M.; McPherson, R.; O'Neil, D.C.; Forbush, D.; Mockett, P.; Toevs, F.; Braun, H.M.; Thadome, J.

2002-01-01

Modules of the ATLAS liquid argon Hadronic End-cap Calorimeter (HEC) were exposed to beams of electrons, muons and pions in the energy range 6≤E≤200 GeV at the CERN SPS. A description of the HEC and of the beam test setup are given. Results on the energy response and resolution are presented and compared with simulations. The ATLAS energy resolution for jets in the end-cap region is inferred and meets the ATLAS requirements

ESTIMACIÓN DE CAUDALES DE AVENIDA Y DELIMITACIÓN DE ÁREAS INUNDABLES MEDIANTE MÉTODOS HIDROMETEOROLÓGICOS E HIDRÁULICOS Y TÉCNICAS S.I.G., ESTUDIO APLICADO AL LITORAL SUR DE LA REGIÓN DE MURCIA

Directory of Open Access Journals (Sweden)

Rafael García Lorenzo

2011-01-01

Full Text Available El presente artículo se centra en el empleo combinado de datos de precipitación, modelos hidrológicos e hidráulicos, y técnicas S.I.G. (Sistema de Información Geográfica para la estimación de caudales de avenidas y la delimitación de áreas inundables en el Sur de la Región de Murcia. Con el fin de obtener datos espacialmente distribuidos en las áreas potenciales de inundación, se han integrado en un S.I.G. diferentes modelos de conversión lluvia-escorrentía superficial (Hidrograma Unitario Adimensional SCS, Hidrograma Unitario Gamma de Témez y el Método Racional Modificado y métodos de geometría hidráulica. Para la conversión de datos de lluvia (tormentas de diseño por periodos de retorno a escorrentía se ha empleado el programa HEC-HMS 3.0.0 en combinación con la extensión HEC-GeoHMS 1.1 de ArcView 3.x. La modelización hidrológica se realiza con ayuda de ArcGIS 9.x y GRASS (v.5.4, mientras que la hidráulica ha requerido el uso de HEC-RAS y HEC-GeoRAS.

In vitro profiling of the vaginal permeation potential of anti-HIV microbicides and the influence of formulation excipients.

Science.gov (United States)

Grammen, Carolien; Augustijns, Patrick; Brouwers, Joachim

2012-11-01

In the search for an effective anti-HIV microbicidal gel, limited drug penetration into the vaginal submucosa is a possible reason for failed protection against HIV transmission. To address this issue in early development, we here describe a simple in vitro strategy to predict the tissue permeation potential of vaginally applied drugs, based on solubility, permeability and flux assessment. We demonstrated this approach for four model microbicides (tenofovir, darunavir, saquinavir mesylate and dapivirine) and additionally examined the influence of formulation excipients on the permeation potential. When formulated in an aqueous-based HEC gel, high flux values across an HEC-1A cell layer were reached by tenofovir, as a result of its high aqueous solubility. In contrast, saquinavir and dapivirine fluxes remained low due to poor permeability and solubility, respectively. These low fluxes suggest limited in vivo tissue penetration, possibly leading to lack of efficacy. Dapivirine fluxes, however, could be enhanced up to 30-fold, by including formulation excipients such as polyethylene glycol 1000 (20%) or cyclodextrins (5%) in the HEC gels. Alternative formulations, i.e. emulsions or silicone elastomer gels, were less effective in flux enhancement compared to cyclodextrin-HEC gels. In conclusion, implementing the proposed solubility and permeability profiling in early microbicide development may contribute to the successful selection of promising microbicide candidates and appropriate formulations. Copyright © 2012 Elsevier B.V. All rights reserved.

Evaluation of insulin secretion and action in New World camelids.

Science.gov (United States)

Firshman, Anna M; Cebra, Christopher K; Schanbacher, Barbara J; Seaquist, Elizabeth R

2013-01-01

To measure and compare insulin secretion and sensitivity in healthy alpacas and llamas via glucose clamping techniques. 8 llamas and 8 alpacas. Hyperinsulinemic euglycemic clamping (HEC) and hyperglycemic clamping (HGC) were performed on each camelid in a crossover design with a minimum 48-hour washout period between clamping procedures. The HEC technique was performed to measure insulin sensitivity. Insulin was infused IV at 6 mU/min/kg for 4 hours, and an IV infusion of glucose was adjusted to maintain blood glucose concentration at 150 mg/dL. Concentrations of blood glucose and plasma insulin were determined throughout. The HGC technique was performed to assess insulin secretion in response to exogenous glucose infusion. An IV infusion of glucose was administered to maintain blood glucose concentration at 320 mg/dL for 3 hours, and concentrations of blood glucose and plasma insulin were determined throughout. Alpacas and llamas were not significantly different with respect to whole-body insulin sensitivity during HEC or in pancreatic β-cell response during HGC. Alpacas and llamas had markedly lower insulin sensitivity during HEC and markedly lower pancreatic β-cell response during HGC, in comparison with many other species. New World camelids had lower glucose-induced insulin secretion and marked insulin resistance in comparison with other species. This likely contributes to the disorders of fat and glucose metabolism that are common to camelids.

Antitumor Effects and Biological Mechanism of Action of the Aqueous Extract of the Camptotheca acuminata Fruit in Human Endometrial Carcinoma Cells

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Chi-Shian Lin

2014-01-01

Full Text Available The aqueous extracts of the leaves and fruit of Camptotheca acuminata have long been used in traditional Chinese medicine (TCM for treating cancer patients. The chemotherapeutic drug, camptothecin (CPT, and related analogs were first isolated from C. acuminata in the 1970s. Although the antitumor effects of CPT have been characterized in recent years, the antitumor effects of aqueous extracts of C. acuminata have not been clarified. The aims of our current study were to determine the tumor-suppression efficiency of an aqueous extract of the fruit of C. acuminata (AE-CA in the human endometrial carcinoma cell lines, HEC-1A, HEC-1B, and KLE, and compare its antitumor effects with those of CPT. Cell viability assays indicated that a dosage of AE-CA containing 0.28 mg/mL of CPT demonstrated enhanced cytotoxicity, compared with CPT treatment. The effects of AE-CA on the induction of cell cycle arrest, the accumulation of cyclin-A2 and -B1, and the activation of caspase-3 and caspase-7 were similar to those of CPT. Furthermore, AE-CA exhibited a synergistic effect on the cytotoxicity of cisplatin in HEC-1A and HEC-1B cells. These results indicated that AE-CA is a potent antitumor agent and can be combined with cisplatin for the treatment of human endometrial cancer.

Investigating the Performance of One- and Two-dimensional Flood Models in a Channelized River Network: A Case Study of the Obion River System

Science.gov (United States)

Kalyanapu, A. J.; Dullo, T. T.; Thornton, J. C.; Auld, L. A.

2015-12-01

Obion River, is located in the northwestern Tennessee region, and discharges into the Mississippi River. In the past, the river system was largely channelized for agricultural purposes that resulted in increased erosion, loss of wildlife habitat and downstream flood risks. These impacts are now being slowly reversed mainly due to wetland restoration. The river system is characterized by a large network of "loops" around the main channels that hold water either from excess flows or due to flow diversions. Without data on each individual channel, levee, canal, or pond it is not known where the water flows from or to. In some segments along the river, the natural channel has been altered and rerouted by the farmers for their irrigation purposes. Satellite imagery can aid in identifying these features, but its spatial coverage is temporally sparse. All the alterations that have been done to the watershed make it difficult to develop hydraulic models, which could predict flooding and droughts. This is especially true when building one-dimensional (1D) hydraulic models compared to two-dimensional (2D) models, as the former cannot adequately simulate lateral flows in the floodplain and in complex terrains. The objective of this study therefore is to study the performance of 1D and 2D flood models in this complex river system, evaluate the limitations of 1D models and highlight the advantages of 2D models. The study presents the application of HEC-RAS and HEC-2D models developed by the Hydrologic Engineering Center (HEC), a division of the US Army Corps of Engineers. The broader impacts of this study is the development of best practices for developing flood models in channelized river systems and in agricultural watersheds.

A self-powered thin-film radiation detector using intrinsic high-energy current

Energy Technology Data Exchange (ETDEWEB)

Zygmanski, Piotr, E-mail: pzygmanski@LROC.HARVARD.EDU, E-mail: Erno-Sajo@uml.edu [Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115 (United States); Sajo, Erno, E-mail: pzygmanski@LROC.HARVARD.EDU, E-mail: Erno-Sajo@uml.edu [Department of Physics and Applied Physics, Medical Physics Program, University of Massachusetts Lowell, Lowell, Massachusetts 01854 (United States)

2016-01-15

Purpose: The authors introduce a radiation detection method that relies on high-energy current (HEC) formed by secondary charged particles in the detector material, which induces conduction current in an external readout circuit. Direct energy conversion of the incident radiation powers the signal formation without the need for external bias voltage or amplification. The detector the authors consider is a thin-film multilayer device, composed of alternating disparate electrically conductive and insulating layers. The optimal design of HEC detectors consists of microscopic or nanoscopic structures. Methods: Theoretical and computational developments are presented to illustrate the salient properties of the HEC detector and to demonstrate its feasibility. In this work, the authors examine single-sandwiched and periodic layers of Cu and Al, and Au and Al, ranging in thickness from 100 nm to 300 μm and separated by similarly sized dielectric gaps, exposed to 120 kVp x-ray beam (half-value thickness of 4.1 mm of Al). The energy deposition characteristics and the high-energy current were determined using radiation transport computations. Results: The authors found that in a dual-layer configuration, the signal is in the measurable range. For a defined total detector thickness in a multilayer structure, the signal sharply increases with decreasing thickness of the high-Z conductive layers. This paper focuses on the computational results while a companion paper reports the experimental findings. Conclusions: Significant advantages of the device are that it does not require external power supply and amplification to create a measurable signal; it can be made in any size and geometry, including very thin (sub-millimeter to submicron) flexible curvilinear forms, and it is inexpensive. Potential applications include medical dosimetry (both in vivo and external), radiation protection, and other settings where one or more of the above qualities are desired.

Uncertainty Assessment: Reservoir Inflow Forecasting with Ensemble Precipitation Forecasts and HEC-HMS

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Sheng-Chi Yang

2014-01-01

Full Text Available During an extreme event, having accurate inflow forecasting with enough lead time helps reservoir operators decrease the impact of floods downstream. Furthermore, being able to efficiently operate reservoirs could help maximize flood protection while saving water for drier times of the year. This study combines ensemble quantitative precipitation forecasts and a hydrological model to provide a 3-day reservoir inflow in the Shihmen Reservoir, Taiwan. A total of six historical typhoons were used for model calibration, validation, and application. An understanding of cascaded uncertainties from the numerical weather model through the hydrological model is necessary for a better use for forecasting. This study thus conducted an assessment of forecast uncertainty on magnitude and timing of peak and cumulative inflows. It found that using the ensemble-mean had less uncertainty than randomly selecting individual member. The inflow forecasts with shorter length of cumulative time had a higher uncertainty. The results showed that using the ensemble precipitation forecasts with the hydrological model would have the advantage of extra lead time and serve as a valuable reference for operating reservoirs.

Cardiovascular Events in Cancer Patients Treated with Highly or Moderately Emetogenic Chemotherapy: Results from a Population-Based Study

International Nuclear Information System (INIS)

Vo, T. T.; Nelson, J. J.

2012-01-01

Studies on cardiovascular safety in cancer patients treated with highly or moderately emetogenic chemotherapy (HEC or MEC), who may have taken the antiemetic, aprepitant, have been limited to clinical trials and postmarketing spontaneous reports. Our study explored background rates of cardiovascular disease (CVD) events among HEC- or MEC-treated cancer patients in a population-based setting to contextualize events seen in a new drug development program and to determine at a high level whether rates differed by aprepitant usage. Medical and pharmacy claims data from the 2005-2007 IMPACT National Benchmark Database were classified into emetogenic chemotherapy categories and CVD outcomes. Among 5827 HEC/MEC-treated patients, frequencies were highest for hypertension (16-21%) and composites of venous (7-12%) and arterial thromboembolic events (4-7%). Aprepitant users generally did not experience higher frequencies of events compared to nonusers. Our study serves as a useful benchmark of background CVD event rates in a population-based setting of cancer patients.

Prototype heel effect compensation filter for cone-beam CT

International Nuclear Information System (INIS)

Mori, Shinichiro; Endo, Masahiro; Nishizawa, Kanae; Ohno, Mari; Miyazaki, Hiroaki; Tsujita, Kazuhiko; Saito, Yasuo

2005-01-01

The prototype cone-beam CT (CBCT) has a larger beam width than the conventional multi-detector row CT (MDCT). This causes a non-uniform angular distribution of the x-ray beam intensity known as the heel effect. Scan conditions for CBCT tube current are adjusted on the anode side to obtain an acceptable clinical image quality. However, as the dose is greater on the cathode side than on the anode side, the signal-to-noise ratio on the cathode side is excessively high, resulting in an unnecessary dose amount. To compensate for the heel effect, we developed a heel effect compensation (HEC) filter. The HEC filter rendered the dose distribution uniform and reduced the dose by an average of 25% for free air and by 20% for CTDI phantoms compared to doses with the conventional filter. In addition, its effect in rendering the effective energy uniform resulted in an improvement in image quality. This new HEC filter may be useful in cone-beam CT studies. (note)

Coordinated Fault Tolerance for High-Performance Computing

Energy Technology Data Exchange (ETDEWEB)

Dongarra, Jack; Bosilca, George; et al.

2013-04-08

Our work to meet our goal of end-to-end fault tolerance has focused on two areas: (1) improving fault tolerance in various software currently available and widely used throughout the HEC domain and (2) using fault information exchange and coordination to achieve holistic, systemwide fault tolerance and understanding how to design and implement interfaces for integrating fault tolerance features for multiple layers of the software stack—from the application, math libraries, and programming language runtime to other common system software such as jobs schedulers, resource managers, and monitoring tools.

Corps Water Management System (CWMS) Decision Support Modeling and Integration Use in the June 2007 Texas Floods

Science.gov (United States)

Charley, W. J.; Luna, M.

2007-12-01

The U.S. Army Corps of Engineers Corps Water Management System (CWMS) is a comprehensive data acquisition and hydrologic modeling system for short-term decision support of water control operations in real time. It encompasses data collection, validation and transformation, data storage, visualization, real time model simulation for decision-making support, and data dissemination. CWMS uses an Oracle database and Sun Solaris workstations for data processes, storage and the execution of models, with a client application (the Control and Visualization Interface, or CAVI) that can run on a Windows PC. CWMS was used by the Lower Colorado River Authority (LCRA) to make hydrologic forecasts of flows on the Lower Colorado River and operate reservoirs during the June 2007 event in Texas. The LCRA receives real-time observed gridded spatial rainfall data from OneRain, Inc. that which is a result of adjusting NexRad rainfall data with precipitation gages. This data is used, along with future precipitation estimates, for hydrologic forecasting by the rainfall-runoff modeling program HEC-HMS. Forecasted flows from HEC-HMS and combined with observed flows and reservoir information to simulate LCRA's reservoir operations and help engineers make release decisions based on the results. The river hydraulics program, HEC-RAS, computes river stages and water surface profiles for the computed flow. An inundation boundary and depth map of water in the flood plain can be calculated from the HEC-RAS results using ArcInfo. By varying future precipitation and releases, engineers can evaluate different "What if?" scenarios. What was described as an "extraordinary cluster of thunderstorms" that stalled over Burnet and Llano counties in Texas on June 27, 2007, dropped 17 to 19 inches of rainfall over a 6-hour period. The storm was classified over a 500-year event and the resulting flow over some of the smaller tributaries as a 100-year or better. CWMS was used by LCRA for flood forecasting and

Preparation of Low Allergenic Protein Concentrated Natural Rubber Latex Using Suitable Low Molecular Weight Cellulose Derivatives Induced by Gamma Irradiation

International Nuclear Information System (INIS)

Siri-Upathum, Chyagrit; Boonyawat, Jariya

2007-08-01

Full text: Low molecular weight carboxy methyl cellulose (CMC), hydroxyl ethyl cellulose (HEC), hydroxyl propyl cellulose (HPC) and methyl cellulose (MC) prepared by radiation-induced degradation were added into diluted natural concentrated latex prior to centrifuge for a purpose of reducing allergenic rubber protein in the latex. Optimum molecular weight (Mv) of CMC and HEC for such a purpose was found to be 17-18 kDa which decreased allergenic rubber protein (14-94 kDa) to an undetectable amount as determined by SDS PAGE method

Coordinated Fault-Tolerance for High-Performance Computing Final Project Report

Energy Technology Data Exchange (ETDEWEB)

Panda, Dhabaleswar Kumar [The Ohio State University; Beckman, Pete

2011-07-28

With the Coordinated Infrastructure for Fault Tolerance Systems (CIFTS, as the original project came to be called) project, our aim has been to understand and tackle the following broad research questions, the answers to which will help the HEC community analyze and shape the direction of research in the field of fault tolerance and resiliency on future high-end leadership systems. Will availability of global fault information, obtained by fault information exchange between the different HEC software on a system, allow individual system software to better detect, diagnose, and adaptively respond to faults? If fault-awareness is raised throughout the system through fault information exchange, is it possible to get all system software working together to provide a more comprehensive end-to-end fault management on the system? What are the missing fault-tolerance features that widely used HEC system software lacks today that would inhibit such software from taking advantage of systemwide global fault information? What are the practical limitations of a systemwide approach for end-to-end fault management based on fault awareness and coordination? What mechanisms, tools, and technologies are needed to bring about fault awareness and coordination of responses on a leadership-class system? What standards, outreach, and community interaction are needed for adoption of the concept of fault awareness and coordination for fault management on future systems? Keeping our overall objectives in mind, the CIFTS team has taken a parallel fourfold approach. Our central goal was to design and implement a light-weight, scalable infrastructure with a simple, standardized interface to allow communication of fault-related information through the system and facilitate coordinated responses. This work led to the development of the Fault Tolerance Backplane (FTB) publish-subscribe API specification, together with a reference implementation and several experimental implementations on top of

Application of the FluEgg model to predict transport of Asian carp eggs in the Saint Joseph River (Great Lakes tributary)

Science.gov (United States)

Garcia, Tatiana; Murphy, Elizabeth A.; Jackson, P. Ryan; Garcia, Marcelo H.

2015-01-01

The Fluvial Egg Drift Simulator (FluEgg) is a three-dimensional Lagrangian model that simulates the movement and development of Asian carp eggs until hatching based on the physical characteristics of the flow field and the physical and biological characteristics of the eggs. This tool provides information concerning egg development and spawning habitat suitability including: egg plume location, egg vertical and travel time distribution, and egg-hatching risk. A case study of the simulation of Asian carp eggs in the Lower Saint Joseph River, a tributary of Lake Michigan, is presented. The river hydrodynamic input for FluEgg was generated in two ways — using hydroacoustic data and using HEC-RAS model data. The HEC-RAS model hydrodynamic input data were used to simulate 52 scenarios covering a broad range of flows and water temperatures with the eggs at risk of hatching ranging from 0 to 93% depending on river conditions. FluEgg simulations depict the highest percentage of eggs at risk of hatching occurs at the lowest discharge and at peak water temperatures. Analysis of these scenarios illustrates how the interactive relation among river length, hydrodynamics, and water temperature influence egg transport and hatching risk. An improved version of FluEgg, which more realistically simulates dispersion and egg development, is presented. Also presented is a graphical user interface that facilitates the use of FluEgg and provides a set of post-processing analysis tools to support management decision-making regarding the prevention and control of Asian carp reproduction in rivers with or without Asian carp populations.

Differential in vitro inhibitory activity against HIV-1 of alpha-(1-3- and alpha-(1-6-D-mannose specific plant lectins : Implication for microbicide development

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Balzarini Jan

2007-06-01

Full Text Available Abstract Background Plant lectins such as Galanthus nivalis agglutinin (GNA and Hippeastrum hybrid agglutinin (HHA are natural proteins able to link mannose residues, and therefore inhibit HIV-target cell interactions. Plant lectins are candidate for microbicide development. Objective To evaluate the activity against HIV of the mannose-specific plant lectins HHA and GNA at the cellular membrane level of epithelial cells and monocyte-derived dendritic cells (MDDC, two potential target cells of HIV at the genital mucosal level. Methods The inhibitory effects of HHA and GNA were evaluated on HIV adsorption to genital epithelial HEC-1A cell line, on HIV transcytosis throughout a monolayer of polarized epithelial HEC-1A cells, on HIV adsorption to MDDC and on transfer of HIV from MDDC to autologous T lymphocytes. Results HHA faintly inhibited attachment to HEC-1A cells of the R5-tropic HIV-1Ba-L strain, in a dose-dependent manner, whereas GNA moderately inhibited HIV adsorption in the same context, but only at high drug doses. Only HHA, but not GNA, inhibited HIV-1JR-CSF transcytosis in a dose-dependent manner. By confocal microscopy, HHA, but not GNA, was adsorbed at the epithelial cell surface, suggesting that HHA interacts specifically with receptors mediating HIV-1 transcytosis. Both plant lectins partially inhibited HIV attachment to MDDC. HHA inhibited more efficiently the transfer of HIV from MDDC to T cell, than GNA. Both HHA and GNA lacked toxicity below 200 μg/ml irrespective the cellular system used and do not disturb the monolayer integrity of epithelial cells. Conclusion These observations demonstrate higher inhibitory activities of the lectin plant HHA by comparison to GNA, on HIV adsorption to HEC-1A cell line, HIV transcytosis through HEC-1A cell line monolayer, HIV adsorption to MDDC and HIV transfer from MDDC to T cells, highlighting the potential interest of HHA as effective microbicide against HIV.

Acute Effects of Aerobic Exercise on Affect and Smoking Craving in the Weeks Before and After a Cessation Attempt.

Science.gov (United States)

Abrantes, Ana M; Farris, Samantha G; Minami, Haruka; Strong, David R; Riebe, Deborah; Brown, Richard A

2018-04-02

Aerobic exercise may improve smoking abstinence via reductions in craving and negative affect and increases in positive moods. Acute changes in craving and affect before and after structured exercise sessions have not been examined during the weeks prior to and following quit attempts nor has smoking status been examined in relation to these effects. Given that regular cigarette smoking can be perceived as affect enhancing and craving reducing, it is not known whether exercise could contribute additional affective benefit beyond these effects. Participants (N = 57; 68.4% women) were low-active daily smokers randomized to cessation treatments plus either group-based aerobic exercise (AE) or a health-education control (HEC). Mood, anxiety, and craving were assessed before and after each intervention session for each of the 12 weeks. Carbon monoxide (CO) breath samples ≤ 5ppm indicated smoking abstinence. During the prequit sessions, significantly greater decreases in anxiety following AE sessions relative to HEC sessions were observed. Changes in mood and craving were similar after AE and HEC sessions prior to quitting. Postquit attempt, significant reductions in craving and anxiety were observed after AE sessions but not following HEC. During the postquit period, positive mood increased following AE sessions relative to HEC only among individuals who were abstinence on that day. AE may be effective in acutely reducing anxiety prior to a quit attempt and both anxiety and craving following the quit attempt regardless of abstinence status. The mood-enhancing effects of AE may occur only in the context of smoking abstinence. The current findings underscore the importance of examining the acute effects of aerobic exercise prior to and after a cessation attempt and as a function of smoking status. Given the equivocal results from previous studies on the efficacy of exercise for smoking cessation, increasing our understanding of how aerobic exercise produces its

On the role of specific interactions in the diffusion of nanoparticles in aqueous polymer solutions.

Science.gov (United States)

Mun, Ellina A; Hannell, Claire; Rogers, Sarah E; Hole, Patrick; Williams, Adrian C; Khutoryanskiy, Vitaliy V

2014-01-14

Understanding nanoparticle diffusion within non-Newtonian biological and synthetic fluids is essential in designing novel formulations (e.g., nanomedicines for drug delivery, shampoos, lotions, coatings, paints, etc.), but is presently poorly defined. This study reports the diffusion of thiolated and PEGylated silica nanoparticles, characterized by small-angle neutron scattering, in solutions of various water-soluble polymers such as poly(acrylic acid) (PAA), poly(N-vinylpyrrolidone) (PVP), poly(ethylene oxide) (PEO), and hydroxyethylcellulose (HEC) probed using NanoSight nanoparticle tracking analysis. Results show that the diffusivity of nanoparticles is affected by their dimensions, medium viscosity, and, in particular, the specific interactions between nanoparticles and the macromolecules in solution; strong attractive interactions such as hydrogen bonding hamper diffusion. The water-soluble polymers retarded the diffusion of thiolated particles in the order PEO > PVP > PAA > HEC whereas for PEGylated silica particles retardation followed the order PAA > PVP = HEC > PEO. In the absence of specific interactions with the medium, PEGylated nanoparticles exhibit enhanced mobility compared to their thiolated counterparts despite some increase in their dimensions.

Palonosetron Prevents Highly Emetogenic Chemotherapy-induced Nausea and Vomiting in Oral Cancer Patients.

Science.gov (United States)

Sento, Shinya; Kitamura, Naoya; Yamamoto, Tetsuya; Nakashiro, Koichi; Hamakawa, Hiroyuki; Ibaragi, Soichiro; Sasaki, Akira; Takamaru, Natsumi; Miyamoto, Yoji; Kodani, Isamu; Ryoke, Kazuo; Mishima, Katsuaki; Ueyama, Yoshiya

2017-12-01

To evaluate the efficacy of palonosetron in preventing acute and delayed nausea and vomiting in patients receiving highly emetogenic chemotherapy (HEC) in oral cancer patients. Oral cancer patients receiving HEC were enrolled; among the 40 patients, 87 courses of chemotherapy were administered. On day 1, 0.75 mg palonosetron was intravenously administrated just before chemotherapy. The primary endpoint was the proportion of patients with a complete response (CR) and the secondary endpoint was the proportion of patients with complete control (CC) during the acute and delayed phase. During the acute phase, 86 of 87 courses (98.9%) had CR and 84 of 87 courses (96.6%) had CC. During the delayed phase, 84 of 87 courses (96.6%) had CR and 70 of 87 courses (80.5%) had CC. Palonosetron is effective at preventing HEC-induced chemotherapy-induced nausea and vomiting (CINV) in oral cancer chemotherapeutic regimens in the acute and delayed phases. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Hydrogel-based electrochemical sensor for non-invasive and continuous glucose monitoring

Science.gov (United States)

Park, Habeen; Lee, Ji-Young; Kim, Dong-Chul; Koh, Younggook; Cha, Junhoe

2017-07-01

Monitoring blood glucose level of diabetic patients is crucial in diabetes care from life threating complications. Selfmonitoring blood glucose (SMBG) that involves finger prick to draw blood samples into the measurement system is a widely-used method of routine measurement of blood glucose levels to date. SMBG includes, however, unavoidable pain problems resulting from the repetitive measurements. We hereby present a hydrogel-based electrochemical (H-EC) sensor to monitor the glucose level, non-invasively. Glucose oxidase (GOx) was immobilized in the disc-type hydroxyethyl methacrylate (HEMA) based hydrogel and kept intact in the hydrogel. Fast electron transfer mediated by Prussian blue (PB, hexacyanoferrate) generated efficient signal amplifications to facilitate the detection of the extracted glucose from the interstitial fluid. The linear response and the selectivity against glucose of the H-EC sensor were validated by chronoamperometry. For the practical use, the outcomes from the correlation of the extracted glucose concentration and the blood glucose value by on-body extraction, as well as the validation of the hydrogel-based electrochemical (H-EC) device, were applied to the on-body glucose monitoring.

FLOOD MODELING OF THE VUKA RIVER SECTION UPSTREAM OF ITS CONFLUENCE WITH THE DANUBE RIVER

Directory of Open Access Journals (Sweden)

Dario Marić

2016-12-01

Full Text Available In this paper, a section of the Vuka River from its confluence with the Danube River in Vukovar to 3 + 630 rkm was modeled. The possibility and size of floods in the surrounding area were analyzed for different return periods (2, 5, 10, 50, and 100 yrs. Although the high-water levels of the Danube River are lower than the terrain elevation of Vukovar, they cause backwater in the Vuka River and in its tributary, the Bobotski canal. In that indirect way, the surrounding area is endangered and the efficiency of drainage systems is reduced. The existing riverbed of the analyzed Vuka River section was digitalized based on a digital terrain model using the geographic information system (GIS software ArcGIS and the HEC-GeoRAS toolbar. A mathematical model of the steady-state flow of the Vuka river section using the digitized riverbed was executed in the HEC-RAS software using different return periods. The obtained velocities and water levels were analyzed using HEC-RAS, and the sizes of the flooded areas were calculated and observed in ArcGIS.

Mucosal integrity and inflammatory markers in the female lower genital tract as potential screening tools for vaginal microbicides.

Science.gov (United States)

Su, H Irene; Schreiber, Courtney A; Fay, Courtney; Parry, Sam; Elovitz, Michal A; Zhang, Jian; Shaunik, Alka; Barnhart, Kurt

2011-11-01

In the female genital tract, vaginal colposcopy, endometrial mucosal integrity and inflammatory mediators are potential in vivo biomarkers of microbicide and contraceptive safety. A randomized, blinded crossover trial of 18 subjects comparing effects of nonoxynol-9 vaginal gel (Gynol II; putative inflammatory gel), hydroxyethyl cellulose gel (HEC; putative inert gel) and no gel exposure on endometrial and vaginal epithelial integrity and endometrial and vaginal inflammatory markers [interleukin (IL) 1β, IL-6, IL-8, MCP-1, MIP-1α, MIP-1β, RANTES, tumor necrosis factor α, IL-1RA, IL-10, SLPI). Gynol II was associated with more vaginal lesions. No endometrial disruptions were observed across conditions. In the vagina, RANTES (p=.055) and IL-6 (p=.04) were higher after HEC exposure than at baseline. In the endometrium, IL-1β (p=.003) and IL-8 (p=.025) were lower after Gynol II cycles than after no gel. Gynol II and HEC may modulate inflammatory markers in the vagina and endometrium. How these changes relate to infection susceptibility warrants further study. Copyright © 2011 Elsevier Inc. All rights reserved.

Acetic acid denaturing pulsed field capillary electrophoresis for RNA separation.

Science.gov (United States)

Li, Zhenqing; Dou, Xiaoming; Ni, Yi; Sumitomo, Keiko; Yamaguchi, Yoshinori

2010-10-01

Based on our previous work of in-capillary denaturing polymer electrophoresis, we present a study of RNA molecular separation up to 6.0 kilo nucleotide by pulsed field CE. This is the first systematic investigation of electrophoresis of a larger molecular mass RNA in linear hydroxyethylcellulose (HEC) under pulsed field conditions. The parameters that may influence the separation performance, e.g. gel polymer concentration, modulation depth and pulse frequency, are analyzed in terms of resolution and mobility. For denaturing and separating RNA in the capillary simultaneously, 2 M acetic acid was added into the HEC polymer to serve as separation buffer. Result shows that (i) in pulsed field conditions, RNA separation can be achieved in a wide range of concentration of HEC polymer, and RNA fragments between 0.3 and 0.6 kilo nucleotide are sensitive to the polymer concentration; (ii) under certain pulsed field conditions, RNA fragments move linearly as the modulation depth increases; (iii) 12.5 Hz is the resonance frequency for RNA reorientation time and applied frequency.

Design, characterization and evaluation of hydroxyethylcellulose based novel regenerable supersorbent for heavy metal ions uptake and competitive adsorption.

Science.gov (United States)

Abbas, Azhar; Hussain, Muhammad Ajaz; Sher, Muhammad; Irfan, Muhammad Imran; Tahir, Muhammad Nawaz; Tremel, Wolfgang; Hussain, Syed Zajif; Hussain, Irshad

2017-09-01

Hydroxyethylcellulose succinate-Na (HEC-Suc-Na) was designed and evaluated for removal of some heavy metal ions from aqueous solution. Pristine sorbent HEC-Suc-Na was thoroughly characterized by FTIR and solid-state CP/MAS 13 C NMR spectroscopy, SEM-EDS and zero point charge analyses. Langmuir isotherm, pseudo second order kinetic and ion exchange models provided best fit to the experimental data of sorption of metal ions. Maximum sorption capacities of supersorbent HEC-Suc-Na for sorption of heavy metal ions from aqueous solution as calculated by Langmuir isotherm model were found to be 1000, 909.09, 666.6, 588 and 500mgg -1 for Pb(II), Cr(VI), Co(II), Cu(II) and Ni(II), respectively. Competitive sorption of these heavy metal ions was carried out from galvanic and nuclear waste water simulated environment. The negative values of ΔG° and ΔH° indicated spontaneity and exothermic nature of sorption. The sorbent was efficiently regenerated with no significant decrease in sorption capacity after five cycles. Copyright © 2017 Elsevier B.V. All rights reserved.

Pemodelan Spasial untuk Pembuatan Peta Rawan Banjir dan Peta Tingkat Risiko Banjir Bengawan Solo di Kota Surakarta

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Toto Cahyono

2016-09-01

Full Text Available ABSTRAK Penelitian ini bertujuan untuk melakukan pemodelan spasial untuk menyusun Peta Bahaya Banjir dan Peta Tingkat Risiko Banjir akibat luapan Bengawan Solo di Kota Surakarta. Lokasi penelitian meliputi penggal alur Bengawan Solo di wilayah Kota Surakarta. Metode penelitian yaitu dengan analisis hidrograf, pemodelan banjir, analisis potensi bahaya banjir, analisis kerentanan banjir, dan analisis tingkat risiko banjir. Analisis hidrograf dilakukan dengan menghitung debit puncak rancangan, analisis geometrik sungai, dan analisis karakteristik banjir. Pemodelan spasial banjir menggunakan perangkat lunak ArcView dengan ekstensi HEC-GeoRAS dan perangkat lunak hidrologi HEC-RAS. Analisis potensi bahaya banjir dari peta genangan hasil pemodelan spasial dengan input debit puncak rancangan banjir periode ulang 60. Analisis kerentanan dengan identifikasi elemen yang berisiko pada peta penggunaan lahan daerah bahaya. Analisis tingkat risiko dilakukan dengan cara overlay peta bahaya dan peta kerentanan banjir. Perangkat lunak ArcView 3.3 dengan ekstensi HEC-GeoRAS mampu untuk melakukan pemodelan banjir dengan tingkat validasi yang tinggi. Validasi dilakukan dengan membandingkan kedalaman maksimum hasil pemodelan dengan hasil perhitungan debit puncak rancangan. Nilai  perbedaan antara 0,68% - 4,54%. Meskipun secara kuantitatif peta model bahaya banjir rancangan sesudah pelurusan lebih luas daripada sebelum pelurusan, tetapi berdasarkan uji statistik penambahan luas tersebut tidak berbeda signifikan. Dari peta tingkat risiko banjir diketahui Kelurahan Sewu, Semanggi, Sangkrah dan Gandekan mempunyai potensi risiko banjir tertinggi di Kota Surakarta.   ABSTRACT This research is intended to perform flood modelling in Bengawan Solo River in order to develop flood hazard map, flood vulnerability map, and flood risk map as a result of overflow of such river in Surakarta City. The research area covers cut-off channel of Bengawan Solo in Surakarta City. The

Evaluation of Different Software Packages in Flow Modeling under Bridge Structures

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Mohammad Taghi Dastorani

2007-01-01

Full Text Available This study is an independent and a comparative research concerning the accuracy, capability and suitability of three well-known packages ofISIS, MIKE11 and HEC-RAS as hydraulic river modeling software packages for modeling the flow through bridges. The research project was designed to assess the ability of each software package to model the flow through bridge structures. It was carried out using the data taken from experiments completed by a 22-meter laboratory flume at theUniversityofBirmingham. The flume has a compound cross section containing a main channel and two flood plains on either side. For this study a smooth main channel and a smooth floodplain have been assumed. Two types of bridges are modeled in this research; a multiple opening semi-circular arch bridge and a single opening straight deck bridge. For each bridge, two different simulations were carried out using two different upstream boundaries as low flow and high flow simulations. According to the results, all three packages were able to model arch and US BPR bridges but in some cases they presented different results. The highest water elevation upstream the bridge (maximum afflux was the main parameter to be compared to the measured values.ISISand HEC-RAS (especially HEC-RAS seem to be more efficient to model arch bridge. However, in some cases, MIKE 11 produced considerably higher results than those of the other two packages. To model USBPR bridge, all three packages produced reasonable results. However, the results by HEC-RAS are the best when the outputs are compared to the experimental data.

Interleukin 2 secretion by lectin-activated human blood lymphocytes is markedly augmented by vascular endothelial cells

International Nuclear Information System (INIS)

Guinan, E.C.; Pober, J.S.

1986-01-01

Since the initial interaction (and possible activation) of a blood borne T lymphocyte involves contact with the endothelial lining of the vasculature at the site of an immune response, the authors have examined the effect of cultured human endothelial cells (HEC) upon polyclonal T cell activation. Addition of 10 4 HEC to 10 4 -10 5 peripheral blood lymphocytes (PBL) stimulated with phytohemagglutinin (PHA, 0.3-10 μg/ml) leads to marked augmentation of interleukin 2 (IL-2) production. The relative increase in IL-2 (mean of 3 expts. +/- SEM) is present at 24 h (5.8 fold +/- 1.5) and become more marked at 48 h (12.6 fold +/- 3.5) and 72 h (18.5 fold +/- 3.7). This relative enhancement is greater for HEC added to 10 4 than 10 5 PBL and is also greater when 10 4 rather than 2 x 10 3 HEC are added to a given number of PBL. This increased IL-2 concentration has two biological consequences. First, at suboptimal PHA doses or at low PBL number, PBL proliferation as measured by 3 H-thymidine incorporation is increased up to two fold. Second, the phenotype of the proliferating cells appears altered, including a decrease in mean density of IL-2 receptor. The authors hypothesize that such modulation of the concentration of locally produced IL-2 may play a key role in the nature of an immune response, influencing both its magnitude and the functional profile of the activated and amplified effector cells

The effect of replacing pnictogen elements on the physical properties SrMg2 {{\\boldsymbol{X}}}_{2} ({\\boldsymbol{X}}=N, P, As, Sb, Bi) Zintl compounds

Science.gov (United States)

Murtaza, G.; Ahad Khan, Abdul; Yaseen, M.; Laref, A.; Ullah, Naeem; Rahman, Inayat ur

2018-04-01

Not Available Project supported by a grant from the “Research Center of Female Scientific and Medical Colleges”, the Deanship of Scientific Research, King Saud University. Yaseen M is thankful to Higher Education Commission (HEC), Pakistan for funding (Grant No. 6410/Punjab/NRPU/R&D/HEC/2016), and also this study is made possible by the support of the United States Government and the American people through the United States Agency for International Development (USAID). The contents are the sole responsibility of National University of Sciences and Technology and do not necessarily reflect the views of USAID or the United States Government.

Federal High End Computing (HEC) Information Portal

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Networking and Information Technology Research and Development, Executive Office of the President — This portal provides information about opportunities to engage in U.S. Federal government high performance computing activities, including supercomputer use,...

Open-label observational study to assess the efficacy and safety of aprepitant for chemotherapy-induced nausea and vomiting prophylaxis in Indian patients receiving chemotherapy with highly emetogenic chemotherapy/moderately emetogenic chemotherapy regimens

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Hingmire Sachin

2015-01-01

Full Text Available Context: Currently, there is limited data on the prevention of chemotherapy-induced nausea and vomiting (CINV in Indian population with aprepitant containing regimens. Aims: The aim was to assess the Efficacy and Safety of Aprepitant for the prevention of nausea and vomiting associated with highly emetogenic chemotherapy/moderately emetogenic chemotherapy (HEC/MEC regimens. Settings and Design: Investigator initiated, multicentric, open-label, prospective, noncomparative, observational trial. Subjects and Methods: Triple drug regimen with aprepitant, palonosetron, and dexamethasaone administration was assessed for the prevention of CINV during acute, delayed, and the overall phase (OP for HEC/MEC Regimens. The primary endpoint was complete response (CR; no emesis and no use of rescue medication and the key secondary endpoint was the complete control (CC; no emesis, no rescue medication and no more than mild nausea during the OP. Statistical Analysis Used: Perprotocol efficacy was analyzed for the first cycle with results represented in terms of CR/CC rates using descriptive statistics. Results: Seventy-five patients were included in the study with median age of 49.7 years and 89.7% being females. The CR rate (OP for patients administered HEC or MEC regimens during the first cycle were 92% and 90.9%, respectively. Similarly, the CC rates (OP were 75% and 90% for these regimens, respectively. 7 (9.2% patients reported adverse drug reactions that were mild and transient with no reports of any serious adverse events. Conclusions: Use of aprepitant containing regimen for patients receiving HEC/MEC regimen resulted in significantly high CR and CC response rates, which further consolidate its potential role to improve patient quality of life and compliance to disease management.

Influences of neutralization of superabsorbent hydrogel from hydroxyethyl cellulose on water swelling capacities

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Adair, Ajaman; Klinpituksa, Pairote; Kaesaman, Azizon

2017-08-01

In this research, superabsorbent hydrogels were synthesized by graft copolymerization of hydroxyethyl cellulose (HEC) and polyacrylamide (PAM) under the initiation of potassium persulfate (KPS). The polymer networks were constructed using N,N'-methylenebisacrylamide (MBA), and the reaction was performed in an aqueous solution. The extent of grafting products was evaluated form grafting efficiency (%GE) and percentage of add-ons at HEC/AM ratios of 1: 10. The water swelling capacities, in terms of swelling capacity and weight loss, of resultant superabsorbent polymers (SAPs) after solvent extraction were determined for swelling behaviors. The result showed that the SAP had poor water absorption of approximately up to 23 g/g. To enhance swelling capacity of SAPs, an alkaline hydrolysis was done by using two types of alkaline bases, i.e., 2 M NaOH and 2 M KOH solution. The obtained treatment SAPs were neutralized by washing with distilled water and 0.5 M HCl until the liquors pH was nearly 7. They were found that the treatment SAPs showed the highest water absorption up to 317 g/g. Influences of various fluids pH values ranging between 4 and 10, on water swelling capacities of SAPs were also investigated. Under optimal pH value, the highest water absorptions of SAP was 382 g/g. To confirm the grafting reaction of PAM onto HEC backbone, FT-IR analysis was used. The results revealed absorption bands of the HEC backbone and new absorption bands from the grafted copolymer. Furthermore, the FT-IR spectrum was proved that washing with distilled water can alter the chemical functional group of SAPs.

Rolapitant: A Review in Chemotherapy-Induced Nausea and Vomiting.

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Heo, Young-A; Deeks, Emma D

2017-10-01

Oral rolapitant (Varubi™; Varuby ® ), a long-acting neurokinin-1 (NK 1 ) receptor antagonist (RA), is indicated in the USA and EU as part of an antiemetic regimen to prevent delayed chemotherapy-induced nausea and vomiting (CINV) in adults receiving highly or moderately emetogenic chemotherapy (HEC or MEC). In randomized, phase III trials, a single oral dose of rolapitant 180 mg was effective in preventing delayed CINV compared with placebo, when each was used in combination with a 5-HT 3 RA plus dexamethasone, in adults receiving their first course of HEC or MEC. The benefits of rolapitant were maintained over multiple cycles of chemotherapy. The tolerability profile of rolapitant is similar to that of placebo and consistent with that of other NK 1 RAs. However, rolapitant differs from other existing NK 1 RAs in that it does not interact with CYP3A4, thereby negating the need for dexamethasone dose adjustments and potentially making rolapitant a more suitable option for patients receiving CYP3A4 substrates. Thus, oral rolapitant is an effective and well tolerated NK 1 RA that expands the treatment options for preventing delayed CINV in adults receiving HEC or MEC.

From reactive to proactive: developing a valid clinical ethics needs assessment survey to support ethics program strategic planning (part 1 of 2).

Science.gov (United States)

Frolic, Andrea; Jennings, Barb; Seidlitz, Wendy; Andreychuk, Sandy; Djuric-Paulin, Angela; Flaherty, Barb; Peace, Donna

2013-03-01

As ethics committees and programs become integrated into the "usual business" of healthcare organizations, they are likely to face the predicament of responding to greater demands for service and higher expectations, without an influx of additional resources. This situation demands that ethics committees and programs allocate their scarce resources (including their time, skills and funds) strategically, rather than lurching from one ad hoc request to another; finding ways to maximize the effectiveness, efficiency, impact and quality of ethics services is essential in today's competitive environment. How can Hospital Ethics Committees (HECs) begin the process of strategic priority-setting to ensure they are delivering services where and how they are most needed? This paper describes the creation of the Clinical Ethics Needs Assessment Survey (CENAS) as a tool to understand interprofessional staff perceptions of the organization's ethical climate, challenging ethical issues and educational priorities. The CENAS was designed to support informed resource allocation and advocacy by HECs. By sharing our process of developing and validating this ethics needs assessment survey we hope to enable strategic priority-setting in other resource-strapped ethics programs, and to empower HECs to shift their focus to more proactive, quality-focused initiatives.

Decontamination and decommissioning project status of the TRIGA Mark II and III in Korea

International Nuclear Information System (INIS)

Paik, S.T.; Park, S.K.; Chung, K.W.; Chung, U.S.; Jung, K.J.

1999-01-01

TRIGA Mark-II, the first research reactor in Korea, has operated since 1962, and the second one, TRIGA Mark-III since 1972. Both of them had their operation phased out in 1995 due to their lives and operation of the new research reactor, HANARO (High-flux Advanced Neutron Application Reactor) at the Korea Atomic Energy Institute (KAERI) in Taejon. Decontamination and decommissioning (D and D) project of TRIGA Mark-II and Mark-III was started in January 1997 and will be completed in December 2002. The first year of the project, work was performed in preparation of the decommissioning plan, start of the environmental impact assessment and setup licensing procedure and documentation for the project with cooperation of Korea Institute of Nuclear Safety (KINS). Hyundai Engineering Company (HEC) is the main contractor to do design and licensing documentation for the D and D of both reactors. British Nuclear Fuels plc (BNFL) is the technical assisting partner of HEC. The decommissioning plan document was submitted to the Ministry of Since and Technology (MOST) for the decommissioning license in December 1998, and it expecting to be issued a license in mid 1999. The goal of this project is to release the reactor site and buildings as an unrestricted area. This paper summarizes current status and future plan for the D and D project. (author)

Sporotrichosis: an emergent zoonosis in Rio de Janeiro

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Barros Mônica Bastos de Lima

2001-01-01

Full Text Available During the period from 1987 to 1998, 13 cases of human sporotrichosis were recorded at the Research Center Evandro Chagas Hospital (CPqHEC in Rio de Janeiro. Two of these patients related scratch by a sick cat. During the subsequent period from July 1998 to July 2000, 66 human, 117 cats and 7 dogs with sporotrichosis were diagnosed at the CPqHEC. Fifty-two humans (78.8% reported contact with cats with sporotrichosis, and 31 (47% of them reporting a history of a scratch or bite. This epidemic, unprecedented in the literature, involving cats, dogs and human beings may have started insidiously before 1998.

Analysis of hydraulic characteristics for stream diversion in small stream

Energy Technology Data Exchange (ETDEWEB)

Ahn, Sang-Jin; Jun, Kye-Won [Chungbuk National University, Cheongju(Korea)

2001-10-31

This study is the analysis of hydraulic characteristics for stream diversion reach by numerical model test. Through it we can provide the basis data in flood, and in grasping stream flow characteristics. Analysis of hydraulic characteristics in Seoknam stream were implemented by using computer model HEC-RAS(one-dimensional model) and RMA2(two-dimensional finite element model). As a result we became to know that RMA2 to simulate left, main channel, right in stream is more effective method in analysing flow in channel bends, steep slope, complex bed form effect stream flow characteristics, than HEC-RAS. (author). 13 refs., 3 tabs., 5 figs.

PROJECT CASCADES OF SMALL DRY RESERVOIRS FOR FLOOD PROTECTION OF URBAN AREAS

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Rafał Antoszewski

2017-02-01

Full Text Available The paper presents the problem of designing an open reservoirs with a capacity of about 100 000 m3 in heavily urbanized areas of anthropogenically transformed natural watercourses with numerous outlets drainage and large sealed surfaces runoff. In particular the issues of the hydrological basics design based on the meteorological data in the catchment uncontrolled water level checkpoints with particular emphasis on the tools of computer-aided modeling of hydrological processes (HEC-HMS, HEC-RAS and available for use mathematical models and statistical rainfall-runoff, this practical the method SCS-CN and linear model cascade tanks Nash to transform the effective precipitation in surface runoff.

Flood Hazard Mapping by Using Geographic Information System and Hydraulic Model: Mert River, Samsun, Turkey

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Vahdettin Demir

2016-01-01

Full Text Available In this study, flood hazard maps were prepared for the Mert River Basin, Samsun, Turkey, by using GIS and Hydrologic Engineering Centers River Analysis System (HEC-RAS. In this river basin, human life losses and a significant amount of property damages were experienced in 2012 flood. The preparation of flood risk maps employed in the study includes the following steps: (1 digitization of topographical data and preparation of digital elevation model using ArcGIS, (2 simulation of flood lows of different return periods using a hydraulic model (HEC-RAS, and (3 preparation of flood risk maps by integrating the results of (1 and (2.

Web services for distributed and interoperable hydro-information systems

Science.gov (United States)

Horak, J.; Orlik, A.; Stromsky, J.

2008-03-01

Web services support the integration and interoperability of Web-based applications and enable machine-to-machine interaction. The concepts of web services and open distributed architecture were applied to the development of T-DSS, the prototype customised for web based hydro-information systems. T-DSS provides mapping services, database related services and access to remote components, with special emphasis placed on the output flexibility (e.g. multilingualism), where SOAP web services are mainly used for communication. The remote components are represented above all by remote data and mapping services (e.g. meteorological predictions), modelling and analytical systems (currently HEC-HMS, MODFLOW and additional utilities), which support decision making in water management.

A randomized control trial to evaluate the importance of pre-training basic laparoscopic psychomotor skills upon the learning curve of laparoscopic intra-corporeal knot tying.

Science.gov (United States)

Molinas, Carlos Roger; Binda, Maria Mercedes; Sisa, Cesar Manuel; Campo, Rudi

2017-01-01

Training of basic laparoscopic psychomotor skills improves the acquisition of more advanced laparoscopic tasks, such as laparoscopic intra-corporeal knot tying (LICK). This randomized controlled trial was designed to evaluate whether pre-training of basic skills, as laparoscopic camera navigation (LCN), hand-eye coordination (HEC), and bimanual coordination (BMC), and the combination of the three of them, has any beneficial effect upon the learning curve of LICK. The study was carried out in a private center in Asunción, Paraguay, by 80 medical students without any experience in surgery. Four laparoscopic tasks were performed in the ENCILAP model (LCN, HEC, BMC, and LICK). Participants were allocated to 5 groups (G1-G5). The study was structured in 5 phases. In phase 1, they underwent a base-line test ( T 1 ) for all tasks (1 repetition of each task in consecutive order). In phase 2, participants underwent different training programs (30 consecutive repetitions) for basic tasks according to the group they belong to (G1: none; G2: LCN; G3: HEC; G4: BMC; and G5: LCN, HEC, and BMC). In phase 3, they were tested again ( T 2 ) in the same manner than at T 1 . In phase 4, they underwent a standardized training program for LICK (30 consecutive repetitions). In phase 5, they were tested again ( T 3 ) in the same manner than at T 1 and T 2 . At each repetition, scoring was based on the time taken for task completion system. The scores were plotted and non-linear regression models were used to fit the learning curves to one- and two-phase exponential decay models for each participant (individual curves) and for each group (group curves). The LICK group learning curves fitted better to the two-phase exponential decay model. From these curves, the starting points ( Y 0), the point after HEC training/before LICK training ( Y 1), the Plateau, and the rate constants ( K ) were calculated. All groups, except for G4, started from a similar point ( Y 0). At Y 1, G5 scored already

Dynamic Non-Hierarchical File Systems for Exascale Storage

Energy Technology Data Exchange (ETDEWEB)

Long, Darrell E. [Univ. of California, Santa Cruz, CA (United States); Miller, Ethan L [Univ. of California, Santa Cruz, CA (United States)

2015-02-24

This constitutes the final report for “Dynamic Non-Hierarchical File Systems for Exascale Storage”. The ultimate goal of this project was to improve data management in scientific computing and high-end computing (HEC) applications, and to achieve this goal we proposed: to develop the first, HEC-targeted, file system featuring rich metadata and provenance collection, extreme scalability, and future storage hardware integration as core design goals, and to evaluate and develop a flexible non-hierarchical file system interface suitable for providing more powerful and intuitive data management interfaces to HEC and scientific computing users. Data management is swiftly becoming a serious problem in the scientific community – while copious amounts of data are good for obtaining results, finding the right data is often daunting and sometimes impossible. Scientists participating in a Department of Energy workshop noted that most of their time was spent “...finding, processing, organizing, and moving data and it’s going to get much worse”. Scientists should not be forced to become data mining experts in order to retrieve the data they want, nor should they be expected to remember the naming convention they used several years ago for a set of experiments they now wish to revisit. Ideally, locating the data you need would be as easy as browsing the web. Unfortunately, existing data management approaches are usually based on hierarchical naming, a 40 year-old technology designed to manage thousands of files, not exabytes of data. Today’s systems do not take advantage of the rich array of metadata that current high-end computing (HEC) file systems can gather, including content-based metadata and provenance1 information. As a result, current metadata search approaches are typically ad hoc and often work by providing a parallel management system to the “main” file system, as is done in Linux (the locate utility), personal computers, and enterprise search

PARP Inhibition Prevents Ethanol-Induced Neuroinflammatory Signaling and Neurodegeneration in Rat Adult-Age Brain Slice Cultures

Science.gov (United States)

Tajuddin, Nuzhath; Kim, Hee-Yong

2018-01-01

Using rat adult-age hippocampal-entorhinal cortical (HEC) slice cultures, we examined the role of poly [ADP-ribose] polymerase (PARP) in binge ethanol’s brain inflammatory and neurodegenerative mechanisms. Activated by DNA strand breaks, PARP (principally PARP1 in the brain) promotes DNA repair via poly [ADP-ribose] (PAR) products, but PARP overactivation triggers regulated neuronal necrosis (e.g., parthanatos). Previously, we found that brain PARP1 levels were upregulated by neurotoxic ethanol binges in adult rats and HEC slices, and PARP inhibitor PJ34 abrogated slice neurodegeneration. Binged HEC slices also exhibited increased Ca+2-dependent phospholipase A2 (PLA2) isoenzymes (cPLA2 IVA and sPLA2 IIA) that mobilize proinflammatory ω6 arachidonic acid (ARA). We now find in 4-day–binged HEC slice cultures (100 mM ethanol) that PARP1 elevations after two overnight binges precede PAR, cPLA2, and sPLA2 enhancements by 1 day and high-mobility group box-1 (HMGB1), an ethanol-responsive alarmin that augments proinflammatory cytokines via toll-like receptor-4 (TLR4), by 2 days. After verifying that PJ34 effectively blocks PARP activity (↑PAR), we demonstrated that, like PJ34, three other PARP inhibitors—olaparib, veliparib, and 4-aminobenzamide—provided neuroprotection from ethanol. Importantly, PJ34 and olaparib also prevented ethanol’s amplification of the PLA2 isoenzymes, and two PLA2 inhibitors were neuroprotective—thus coupling PARP to PLA2, with PLA2 activity promoting neurodegeneration. Also, PJ34 and olaparib blocked ethanol-induced HMGB1 elevations, linking brain PARP induction to TLR4 activation. The results provide evidence in adult brains that induction of PARP1 may mediate dual neuroinflammatory pathways (PLA2→phospholipid→ARA and HMGB1→TLR4→proinflammatory cytokines) that are complicit in binge ethanol-induced neurodegeneration. PMID:29339456

Antitumor effects of metformin via indirect inhibition of protein phosphatase 2A in patients with endometrial cancer.

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Shinsuke Hanawa

Full Text Available Metformin, an antidiabetic drug, inhibits the endometrial cancer cell growth in vivo by improving the insulin resistance; however, its mechanism of action is not completely understood. Protein phosphatase 2A (PP2A is a serine/threonine phosphatase associated with insulin resistance and type 2 diabetes, and its inhibition restores the insulin resistance. This study investigated the antitumor effect of metformin on endometrial cancer with a focus on PP2A.Metformin (1,500-2,250 mg/day was preoperatively administered to patients with endometrial cancer for 4 to 6 weeks. Expression of the PP2A regulatory subunits, 4 (PPP2R4 and B (PP2A-B, was evaluated using real-time polymerase chain reaction (RT-PCR and immunohistochemistry (IHC using paired specimens obtained before and after metformin treatment. The effect of PPP2R4 inhibition with small interfering RNA was evaluated in the endometrial cancer cell lines HEC265 and HEC1B. P values of < .05 were considered statistically significant.Preoperative metformin treatment significantly reduced the expression of PP2A-B, as determined using IHC, and the mRNA expression of PPP2R4, as determined using RT-PCR, in the patients with endometrial cancer. However, metformin could not directly alter the PPP2R4 mRNA levels in the endometrial cancer cell lines in vitro. PPP2R4 knockdown reduced the proliferation and induced the apoptosis by activating caspases 3/7 in HEC265 and HEC1B cells.Downregulation of the PP2A-B subunit, including PPP2R4, is an important indirect target of metformin. Inhibition of PP2A may be an option for the treatment of endometrial cancer patients with insulin resistance.This trial is registered with UMIN-CTR (number UMIN000004852.

Rikkunshito for Preventing Chemotherapy-Induced Nausea and Vomiting in Lung Cancer Patients: Results from 2 Prospective, Randomized Phase 2 Trials

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Toshiyuki Harada

2018-01-01

Full Text Available The herbal medicine rikkunshito has the potential to improve chemotherapy-induced nausea and vomiting (CINV by stimulating ghrelin secretion. We aimed to evaluate the efficacy and safety of rikkunshito in preventing CINV for patients with lung cancer. Two separate prospective, randomized, phase II parallel design studies were conducted in patients with lung cancer. Fifty-eight and sixty-two patients scheduled to receive highly emetogenic chemotherapy (HEC and moderately emetogenic chemotherapy (MEC, respectively, were randomized 1:1 to receive either standard antiemetic therapy in accordance with international guidelines (S group or standard antiemetic therapy plus oral rikkunshito (R group. The primary endpoint was overall complete response (CR—that is, no emesis and rescue medication in the first 120 h post-chemotherapy. Secondary endpoints included CR in the acute (0–24 h and delayed (>24–120 h phases and safety. Fifty-seven patients (S group, 28; R group, 29 receiving HEC and sixty-two patients (S group, 30; R group, 32 receiving MEC with comparable characteristics were evaluated. The CR rates were similar across the S and R groups for the HEC study in the overall (67.9% vs. 62.1%, acute (96.4% vs. 89.6%, and delayed (67.9% vs. 62.1% phases, respectively, and for the MEC study in the overall (83.3% vs. 84.4%, acute (100% vs. 100%, and delayed (83.3% vs. 84.4% phases, respectively. No severe adverse events were observed. Although rikkunshito was well tolerated, it did not demonstrate an additional preventative effect against CINV in lung cancer patients receiving HEC or MEC.Clinical Trial Registry Information: This study is registered with the University Hospital Medical Information Network (UMIN Clinical Trial Registry1, identification numbers UMIN 000014239 and UMIN 000014240.

Changing stakeholder relationships in nature reserve management: a case study on Snake Island-Laotie Mountain National Nature Reserve, Liaoning, China.

Science.gov (United States)

Zhou, Dan; Wang, Ziyan; Lassoie, James; Wang, Xiaoping; Sun, Lixin

2014-12-15

The number and total area of nature reserves in China has increased rapidly over the past couple of decades; however, the ability to effectively manage these reserves has not kept pace and conflicts between conservation efforts and economic development have emerged. The Snake Island-Laotie Mountain National Nature Reserve (SILMNNR) currently is experiencing the challenges of balancing conservation with local community development. This paper uses components analysis of human ecosystems (HEC) to examine conflicts arising from the management of the nature reserve and uses a stakeholder analysis to identify and better understand stakeholder inter-relationships in the SILMNNR-HEC. The goal of this study is to identify critical factors influencing stakeholder relationships in order to find ways of relieving conflicts between the reserve management and development. The stakeholder analysis revealed that the key stakeholders in the SILMNNR-HEC are natural resources, the Liaoning SILMNNR Authority, local residents, and enterprise developers; however, there was unequal power among stakeholders in the decision making process affecting the nature reserve. The paper evaluated the conditions and processes of SILMNNR-HEC through a framework of stakeholder relationships where critical factors, such as policy, finance, technology, and labor, and their respective strengths and feedbacks among stakeholders, were assessed and showed unequal flows of power among stakeholders. Two approaches are provided for transforming the unbalanced relationships into a stable and sustainable framework to sustainably manage the nature reserve: the first is by changing stakeholder relationships from opposition to cooperation; and the second by enhancing feedbacks and dynamics among stakeholders. The analysis used in this paper can be used as a model to assess conflicts around other protected areas in China and elsewhere. Copyright © 2014 Elsevier Ltd. All rights reserved.

Remediation scenarios for attenuating peak flows and reducing sediment transport in Fountain Creek, Colorado, 2013

Science.gov (United States)

Kohn, Michael S.; Fulton, John W.; Williams, Cory A.; Stogner, Sr., Robert W.

2014-01-01

The U.S. Geological Survey (USGS) in cooperation with the Fountain Creek Watershed, Flood Control and Greenway District assessed remediation scenarios to attenuate peak flows and reduce sediment loads in the Fountain Creek watershed. To evaluate these strategies, the U.S. Army Corps of Engineers Hydrologic Engineering Center (HEC) hydrologic and hydraulic models were employed. The U.S. Army Corps of Engineers modeling system HEC-HMS (Hydrologic Modeling System) version 3.5 was used to simulate runoff in the Fountain Creek watershed, Colorado, associated with storms of varying magnitude and duration. Rain-gage precipitation data and radar-based precipitation data from the April 28–30, 1999, and September 14–15, 2011, storm events were used in the calibration process for the HEC-HMS model. The curve number and lag time for each subwatershed and Manning's roughness coefficients for each channel reach were adjusted within an acceptable range so that the simulated and measured streamflow hydrographs for each of the 12 USGS streamgages approximated each other. The U.S. Army Corps of Engineers modeling system HEC-RAS (River Analysis System) versions 4.1 and 4.2 were used to simulate streamflow and sediment transport, respectively, for the Fountain Creek watershed generated by a particular storm event. Data from 15 USGS streamgages were used for model calibration and 7 of those USGS streamgages were used for model validation. The calibration process consisted of comparing the simulated water-surface elevations and the cross-section-averaged velocities from the model with those surveyed in the field at the cross section at the corresponding 15 and 7 streamgages, respectively. The final Manning’s roughness coefficients were adjusted between –30 and 30 percent at the 15 calibration streamgages from the original left, right, and channel-averaged Manning's roughness coefficients upon completion of calibration. The U.S. Army Corps of Engineers modeling system HEC

Development and characterization of a gastroretentive dosage form composed of chitosan and hydroxyethyl cellulose for alendronate.

Science.gov (United States)

Chen, Ying-Chen; Ho, Hsiu-O; Chiu, Chiao-Chi; Sheu, Ming-Thau

2014-01-01

In this study, alendronate, the most commonly used biphosphonate for treating osteoporosis, was formulated as gastroretentive dosage form (GRDF) tablets to enhance its oral bioavailability. GRDF tablets were characterized with the effects of different molecular weights (MWs) of chitosan (CS) and hydroxyethyl cellulose (HEC) at various ratios on swelling, floating, and physical integrity. The CS component was formed using various acids: acetic, lactic, malic, succinic, and citric, and a high viscosity grade of HEC was selected. The results demonstrated that the swelling ratios of the formulations comprising high MW CS were lower than those of low or medium MW CS when salts were formed with any countering acids except for acetic acid. The decreasing ranking of the swelling rates was: CS-citrate > CS-malate > CS-lactate > CS-succinate > CS-acetate. A negative correlation was found between the pKa of the respective countering acid and the swelling rate. The swelling rate was promoted if an acidic salt of CS with a lower water content was incorporated, while it became slower when tablet hardness was higher or the compression force to form tablets was increased. Although HEC did not contribute to swelling or floating, it played a role in maintaining structural integrity. A prolonged dissolution profile of alendronate GRDF tablets developed in this study was observed.

Clay Nanoparticles Elicit Long-Term Immune Responses by Forming Biodegradable Depots for Sustained Antigen Stimulation.

Science.gov (United States)

Chen, Weiyu; Zuo, Huali; Li, Bei; Duan, Chengcheng; Rolfe, Barbara; Zhang, Bing; Mahony, Timothy J; Xu, Zhi Ping

2018-05-01

Nanomaterials have been widely tested as new generation vaccine adjuvants, but few evoke efficient immunoreactions. Clay nanoparticles, for example, layered double hydroxide (LDH) and hectorite (HEC) nanoparticles, have shown their potent adjuvanticity in generating effective and durable immune responses. However, the mechanism by which clay nanoadjuvants stimulate the immune system is not well understood. Here, it is demonstrated that LDH and HEC-antigen complexes form loose agglomerates in culture medium/serum. They also form nodules with loose structures in tissue after subcutaneous injection, where they act as a depot for up to 35 d. More importantly, clay nanoparticles actively and continuously recruit immune cells into the depot for up to one month, and stimulate stronger immune responses than FDA-approved adjuvants, Alum and QuilA. Sustained antigen release is also observed in clay nanoparticle depots, with 50-60% antigen released after 35 d. In contrast, Alum-antigen complexes show minimal antigen release from the depot. Importantly, LDH and HEC are more effective than QuilA and Alum in promoting memory T-cell proliferation. These findings suggest that both clay nanoadjuvants can serve as active vaccine platforms for sustained and potent immune responses. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Numerical Analysis of Flood modeling of upper Citarum River under Extreme Flood Condition

Science.gov (United States)

Siregar, R. I.

2018-02-01

This paper focuses on how to approach the numerical method and computation to analyse flood parameters. Water level and flood discharge are the flood parameters solved by numerical methods approach. Numerical method performed on this paper for unsteady flow conditions have strengths and weaknesses, among others easily applied to the following cases in which the boundary irregular flow. The study area is in upper Citarum Watershed, Bandung, West Java. This paper uses computation approach with Force2 programming and HEC-RAS to solve the flow problem in upper Citarum River, to investigate and forecast extreme flood condition. Numerical analysis based on extreme flood events that have occurred in the upper Citarum watershed. The result of water level parameter modeling and extreme flood discharge compared with measurement data to analyse validation. The inundation area about flood that happened in 2010 is about 75.26 square kilometres. Comparing two-method show that the FEM analysis with Force2 programs has the best approach to validation data with Nash Index is 0.84 and HEC-RAS that is 0.76 for water level. For discharge data Nash Index obtained the result analysis use Force2 is 0.80 and with use HEC-RAS is 0.79.

Flood routing modelling with Artificial Neural Networks

Directory of Open Access Journals (Sweden)

R. Peters

2006-01-01

Full Text Available For the modelling of the flood routing in the lower reaches of the Freiberger Mulde river and its tributaries the one-dimensional hydrodynamic modelling system HEC-RAS has been applied. Furthermore, this model was used to generate a database to train multilayer feedforward networks. To guarantee numerical stability for the hydrodynamic modelling of some 60 km of streamcourse an adequate resolution in space requires very small calculation time steps, which are some two orders of magnitude smaller than the input data resolution. This leads to quite high computation requirements seriously restricting the application – especially when dealing with real time operations such as online flood forecasting. In order to solve this problem we tested the application of Artificial Neural Networks (ANN. First studies show the ability of adequately trained multilayer feedforward networks (MLFN to reproduce the model performance.

US QCD computational performance studies with PERI

International Nuclear Information System (INIS)

Zhang, Y; Fowler, R; Huck, K; Malony, A; Porterfield, A; Reed, D; Shende, S; Taylor, V; Wu, X

2007-01-01

We report on some of the interactions between two SciDAC projects: The National Computational Infrastructure for Lattice Gauge Theory (USQCD), and the Performance Engineering Research Institute (PERI). Many modern scientific programs consistently report the need for faster computational resources to maintain global competitiveness. However, as the size and complexity of emerging high end computing (HEC) systems continue to rise, achieving good performance on such systems is becoming ever more challenging. In order to take full advantage of the resources, it is crucial to understand the characteristics of relevant scientific applications and the systems these applications are running on. Using tools developed under PERI and by other performance measurement researchers, we studied the performance of two applications, MILC and Chroma, on several high performance computing systems at DOE laboratories. In the case of Chroma, we discuss how the use of C++ and modern software engineering and programming methods are driving the evolution of performance tools

Evaluating the effects of dam breach methodologies on Consequence Estimation through Sensitivity Analysis

Science.gov (United States)

Kalyanapu, A. J.; Thames, B. A.

2013-12-01

Dam breach modeling often includes application of models that are sophisticated, yet computationally intensive to compute flood propagation at high temporal and spatial resolutions. This results in a significant need for computational capacity that requires development of newer flood models using multi-processor and graphics processing techniques. Recently, a comprehensive benchmark exercise titled the 12th Benchmark Workshop on Numerical Analysis of Dams, is organized by the International Commission on Large Dams (ICOLD) to evaluate the performance of these various tools used for dam break risk assessment. The ICOLD workshop is focused on estimating the consequences of failure of a hypothetical dam near a hypothetical populated area with complex demographics, and economic activity. The current study uses this hypothetical case study and focuses on evaluating the effects of dam breach methodologies on consequence estimation and analysis. The current study uses ICOLD hypothetical data including the topography, dam geometric and construction information, land use/land cover data along with socio-economic and demographic data. The objective of this study is to evaluate impacts of using four different dam breach methods on the consequence estimates used in the risk assessments. The four methodologies used are: i) Froehlich (1995), ii) MacDonald and Langridge-Monopolis 1984 (MLM), iii) Von Thun and Gillete 1990 (VTG), and iv) Froehlich (2008). To achieve this objective, three different modeling components were used. First, using the HEC-RAS v.4.1, dam breach discharge hydrographs are developed. These hydrographs are then provided as flow inputs into a two dimensional flood model named Flood2D-GPU, which leverages the computer's graphics card for much improved computational capabilities of the model input. Lastly, outputs from Flood2D-GPU, including inundated areas, depth grids, velocity grids, and flood wave arrival time grids, are input into HEC-FIA, which provides the

Evacuation Shelters - MDC_HurricaneShelter

Data.gov (United States)

NSGIC Local Govt | GIS Inventory — A label feature class of Miami-Dade County Hurricane Evacuation Shelters (HEC) including Special Need Evacuation Centers (SNEC) and Medical Management Facilities...

HEC influence on cement hydration measured by conductometry

OpenAIRE

Pourchez , Jérémie; Grosseau , Philippe; Guyonnet , René; Ruot , Bertrand

2006-01-01

International audience; Cellulose ethers are of universal use in factory-made mortars, though their influences on mortar properties at a molecular scale are poorly understood. Recent studies dealt with the influence of hydroxyethylmethyl cellulose (HEMC) and hydroxypropylmethyl cellulose (HPMC) molecular parameters on cement hydration. It was concluded that the degree of substitution is the most relevant factor on cement hydration kinetics, contrary to the molecular weight. Nevertheless, the ...

Phase I randomized safety study of twice daily dosing of acidform vaginal gel: candidate antimicrobial contraceptive.

Directory of Open Access Journals (Sweden)

Marla J Keller

Full Text Available BACKGROUND: Acidform gel, an acid-buffering product that inactivates spermatozoa, may be an effective topical non-hormonal contraceptive. This study was designed to evaluate the safety of vaginal dosing and effects of Acidform on mucosal immune mediators, antimicrobial properties of genital secretions, and vaginal microbiota. METHODS: Thirty-six sexually abstinent U.S. women were randomized to apply Acidform or hydroxyethylcellulose (HEC placebo gel twice daily for 14 consecutive days. Safety was assessed by symptoms and pelvic examination. The impact of gel on mucosal immunity was assessed by quantifying cytokines, chemokines, antimicrobial proteins and antimicrobial activity of genital secretions collected by cervicovaginal lavage (CVL at screening, 2 hours after gel application, and on days 7, 14 and 21. Vaginal microbiota was characterized at enrollment and day 14 using species-specific quantitative PCR assays. RESULTS: The median vaginal and cervical pH was significantly lower 2 hours after application of Acidform and was associated with an increase in the bactericidal activity of CVL against E. coli. However, 65% of women who received Acidform had at least one local adverse event compared with 11% who received placebo (p = 0.002. While there was no increase in inflammatory cytokines or chemokines, CVL concentrations of lactoferrin and interleukin-1 receptor antagonist (IL-1ra, an anti-inflammatory protein, were significantly lower following Acidform compared to HEC placebo gel application. There were no significant changes in Lactobacillus crispatus or Lactobacillus jensenii in either group but there was a decrease in Gardnerella vaginalis in the Acidform group (p = 0.08. CONCLUSIONS: Acidform gel may augment mucosal defense as evidenced by an increase in bactericidal activity of genital secretions against E. coli and a decrease in Gardnerella vaginalis colonization. However, Acidform was associated with more irritation than

Phase I Randomized Safety Study of Twice Daily Dosing of Acidform Vaginal Gel: Candidate Antimicrobial Contraceptive

Science.gov (United States)

Keller, Marla J.; Carpenter, Colleen A.; Lo, Yungtai; Einstein, Mark H.; Liu, Congzhou; Fredricks, David N.; Herold, Betsy C.

2012-01-01

Background Acidform gel, an acid-buffering product that inactivates spermatozoa, may be an effective topical non-hormonal contraceptive. This study was designed to evaluate the safety of vaginal dosing and effects of Acidform on mucosal immune mediators, antimicrobial properties of genital secretions, and vaginal microbiota. Methods Thirty-six sexually abstinent U.S. women were randomized to apply Acidform or hydroxyethylcellulose (HEC) placebo gel twice daily for 14 consecutive days. Safety was assessed by symptoms and pelvic examination. The impact of gel on mucosal immunity was assessed by quantifying cytokines, chemokines, antimicrobial proteins and antimicrobial activity of genital secretions collected by cervicovaginal lavage (CVL) at screening, 2 hours after gel application, and on days 7, 14 and 21. Vaginal microbiota was characterized at enrollment and day 14 using species-specific quantitative PCR assays. Results The median vaginal and cervical pH was significantly lower 2 hours after application of Acidform and was associated with an increase in the bactericidal activity of CVL against E. coli. However, 65% of women who received Acidform had at least one local adverse event compared with 11% who received placebo (p = 0.002). While there was no increase in inflammatory cytokines or chemokines, CVL concentrations of lactoferrin and interleukin-1 receptor antagonist (IL-1ra), an anti-inflammatory protein, were significantly lower following Acidform compared to HEC placebo gel application. There were no significant changes in Lactobacillus crispatus or Lactobacillus jensenii in either group but there was a decrease in Gardnerella vaginalis in the Acidform group (p = 0.08). Conclusions Acidform gel may augment mucosal defense as evidenced by an increase in bactericidal activity of genital secretions against E. coli and a decrease in Gardnerella vaginalis colonization. However, Acidform was associated with more irritation than placebo and lower levels

Numerical Simulation of Flood Levels for Tropical Rivers

International Nuclear Information System (INIS)

Mohammed, Thamer Ahmed; Said, Salim; Bardaie, Mohd Zohadie; Basri, Shah Nor

2011-01-01

Flood forecasting is important for flood damage reduction. As a result of advances in the numerical methods and computer technologies, many mathematical models have been developed and used for hydraulic simulation of the flood. These simulations usually include the prediction of the flood width and depth along a watercourse. Results obtained from the application of hydraulic models will help engineers to take precautionary measures to minimize flood damage. Hydraulic models were used to simulate the flood can be classified into dynamic hydraulic models and static hydraulic models. The HEC-2 static hydraulic model was used to predict water surface profiles for Linggi river and Langat river in Malaysia. The model is based on the numerical solution of the one dimensional energy equation of the steady gradually varied flow using the iteration technique. Calibration and verification of the HEC-2 model were conducted using the recorded data for both rivers. After calibration, the model was applied to predict the water surface profiles for Q10, Q30, and Q100 along the watercourse of the Linggi river. The water surface profile for Q200 for Langat river was predicted. The predicted water surface profiles were found in agreement with the recorded water surface profiles. The value of the maximum computed absolute error in the predicted water surface profile was found to be 500 mm while the minimum absolute error was 20 mm only.

Effects of plane of nutrition and feed deprivation on insulin responses in dairy cattle during late gestation.

Science.gov (United States)

Schoenberg, K M; Ehrhardt, R M; Overton, T R

2012-02-01

Nonlactating Holstein cows (n=12) in late pregnancy were used to determine effects of plane of nutrition followed by feed deprivation on metabolic responses to insulin. Beginning 48 d before expected parturition, cows were fed to either a high plane (HP) or a low plane (LP) of nutrition (162 and 90% of calculated energy requirements, respectively). Cows were subjected to an intravenous glucose tolerance test [GTT; 0.25 g of dextrose/kg of body weight (BW)] on d 14 of treatment and a hyperinsulinemic-euglycemic clamp (HEC; 1 μg/kg of BW/h) on d 15. Following 24 h of feed removal, cows were subjected to a second GTT on d 17 and a second HEC on d 18 after 48 h of feed removal. During the feeding period, plasma nonesterified fatty acid (NEFA) concentrations were higher for cows fed the LP diet compared with those fed the HP diet (163.6 vs. 73.1 μEq/L), whereas plasma insulin was higher for cows fed the HP diet during the feeding period (11.1 vs. 5.2 μIU/mL). Glucose areas under the curve during both GTT were higher for cows fed the LP diet than for those fed the HP diet (4,213 vs. 3,750 mg/dL × 60 min) and was higher during the GTT in the feed-deprived state (4,878 vs. 3,085 mg/dL × 60 min) than in the GTT during the fed state, suggesting slower clearance of glucose during negative energy balance either pre-or post-feed deprivation. This corresponded with a higher dextrose infusion rate during the fed-state HEC than during the feed-deprived-state HEC (203.3 vs. 90.1 mL/h). Plasma NEFA decreased at a faster rate following GTT during feed deprivation compared with that during the fed state (8.7 vs. 2.9%/min). Suppression of NEFA was highest for cows fed the HP diet during the GTT conducted during feed deprivation, and lowest for cows fed the HP diet during the fed-state GTT (68.6 vs. 50.3% decrease from basal). Plasma insulin responses to GTT were affected by feed deprivation such that cows had a much lower insulin response to GTT by 24 h after feed removal (995 vs

Application of numerical model simulations for estimation of morphdynamics and vegetation impact on transport of dissolved substances in the Warta river reach

Directory of Open Access Journals (Sweden)

Joanna Wicher-Dysarz

2014-12-01

Full Text Available The main problem analysed in this paper is the impact of sediment accumulation and vegetation growth on transport of dissolved substances in a river. The system studied is the reach of the Warta River located upstream of the Jeziorsko Reservoir inlet. The three processes, namely sediment deposition, vegetation growth, and pollutant transport, are crucial for the functionality of reservoir. Classical HEC-RAS package is used for the reconstruction of steady flow conditions in the river reach. The transport of admixture is simulated by means of convection – dispersion model with additional elements describing storage of solutes in the floodplains. The results that the degree of maximum concentration decreases as the river bed geometry and vegetation cover are changed.

The Ecosystem Functions Model: A Tool for Restoration Planning

National Research Council Canada - National Science Library

Hickey, John T; Dunn, Chris N

2004-01-01

.... Army Corps of Engineers Hydrologic Engineering Center (HEC) is developing the EFM and envisions environmental planners, biologists, and engineers using the model to help determine whether proposed alternatives (e.g...

Hydrologic Engineering Center

Data.gov (United States)

Federal Laboratory Consortium — The Hydrologic Engineering Center (HEC), an organization within the Institute for Water Resources, is the designated Center of Expertise for the U.S. Army Corps of...

Flooding studies of proposed repository locations in the Palo Duro Basin of the Texas Panhandle

International Nuclear Information System (INIS)

1985-04-01

This report contains the results of flooding studies of those stream channels that drain the proposed locations of a high-level nuclear-waste repository in Deaf Smith and Swisher Counties, Texas. Included are computations of the flood hydrographs and water surface profiles of the 100-year, 500-year, and probable maximum floods for Palo Duro Creek, Tule Creek, and Pleasant Draw. The hydrographs were produced according to the method of the Soil Conservation Service for ungaged watersheds, and the computations were made with computer programs developed by the US Army Corps of Engineers. The flood hydrographs were computed with the HEC-1 Flood Hydrograph Package and the water surface elevations with the HEC-2 Water Surface Profiles program. 76 refs., 19 figs., 16 tabs

Flood Modelling of Banjir Kanal Barat (Integration of Hydrology Model and GIS

Directory of Open Access Journals (Sweden)

Muhammad Aris Marfai

2004-01-01

Full Text Available Hydrological modelling has an advantage on river flood study. Hydrological factors can be easily determined and calculated using hydrological model. HEC-RAS (Hydrological Engineering Centre-River Analysis System software is well known as hydrological modelling software for flood simulation and encroachment analysis of the floodplain area. For spatial performance and analysis of flood, the integration of the Geographic Information Systems (GIS and hydrological model is needed. The aims of this research are 1 to perform a flood encroachment using HEC-RAS software, and 2 to generate a flood hazard map. The methodology for this research omprise of 1 generating geometric data as a requirement of the data input on HEC-RAS hydrological model, 2 Hydrological data inputting, 3 generating of the flood encroachment analysis, and 4 transformation of flood encroachment into flood hazard map. The spatial pattern of the flood hazard is illustrated in a map. The result shows that hydrological model as integration with GIS can be used for flood hazard map generation. This method has advantages on the calculation of the hydrological factors of flood and spatial performance of the flood hazard map. For further analysis, the landuse map can be used on the overlay operation with the flood hazard map in order to obtain the impact of the flood on the landuse.

Uncertainty of the peak flow reconstruction of the 1907 flood in the Ebro River in Xerta (NE Iberian Peninsula)

Science.gov (United States)

Ruiz-Bellet, Josep Lluís; Castelltort, Xavier; Balasch, J. Carles; Tuset, Jordi

2017-02-01

There is no clear, unified and accepted method to estimate the uncertainty of hydraulic modelling results. In historical floods reconstruction, due to the lower precision of input data, the magnitude of this uncertainty could reach a high value. With the objectives of giving an estimate of the peak flow error of a typical historical flood reconstruction with the model HEC-RAS and of providing a quick, simple uncertainty assessment that an end user could easily apply, the uncertainty of the reconstructed peak flow of a major flood in the Ebro River (NE Iberian Peninsula) was calculated with a set of local sensitivity analyses on six input variables. The peak flow total error was estimated at ±31% and water height was found to be the most influential variable on peak flow, followed by Manning's n. However, the latter, due to its large uncertainty, was the greatest contributor to peak flow total error. Besides, the HEC-RAS resulting peak flow was compared to the ones obtained with the 2D model Iber and with Manning's equation; all three methods gave similar peak flows. Manning's equation gave almost the same result than HEC-RAS. The main conclusion is that, to ensure the lowest peak flow error, the reliability and precision of the flood mark should be thoroughly assessed.

Plasma concentrations and subcutaneous adipose tissue mRNA expression of clusterin in obesity and type 2 diabetes mellitus: the effect of short-term hyperinsulinemia, very-low-calorie diet and bariatric surgery.

Science.gov (United States)

Kloučková, J; Lacinová, Z; Kaválková, P; Trachta, P; Kasalický, M; Haluzíková, D; Mráz, M; Haluzík, M

2016-07-18

Clusterin is a heterodimeric glycoprotein with wide range of functions. To further explore its possible regulatory role in energy homeostasis and in adipose tissue, we measured plasma clusterin and its mRNA expression in subcutaneous adipose tissue (SCAT) of 15 healthy lean women, 15 obese women (OB) and 15 obese women with type 2 diabetes mellitus (T2DM) who underwent a 2-week very low-calorie diet (VLCD), 10 obese women without T2DM who underwent laparoscopic sleeve gastrectomy (LSG) and 8 patients with T2DM, 8 patients with impaired glucose tolerance (IGT) and 8 normoglycemic patients who underwent hyperinsulinemic euglycemic clamp (HEC). VLCD decreased plasma clusterin in OB but not in T2DM patients while LSG and HEC had no effect. Clusterin mRNA expression in SCAT at baseline was increased in OB and T2DM patients compared with controls. Clusterin mRNA expression decreased 6 months after LSG and remained decreased 12 months after LSG. mRNA expression of clusterin was elevated at the end of HEC compared with baseline only in normoglycemic but not in IGT or T2DM patients. In summary, our data suggest a possible local regulatory role for clusterin in the adipose tissue rather than its systemic involvement in the regulation of energy homeostasis.

12-O-Tetradecanoyl-phorbol-13-acetate and its relationship to SCE induction in Syrian and Chinese hamster cells

International Nuclear Information System (INIS)

Popescu, N.C.; Amsbaugh, S.C.; Larramendy, M.L.; DiPaolo

1982-01-01

12-O-Tetradecanoyl-phorbol-13-acetate (TPA) in conditions that produce enhancement of ultraviolet light (UV) and x-irradiation Syrian hamster embryo cell (HEC) transformation did not cause further increase in the sister chromatid exchange (SCE) frequency induced by UV and x-irradiation, two physical carcinogens that differ in their mode of DNA interaction and efficiency of SCE induction. Several factors which might influence SCE induction by TPA were studied on HEC and Chinese hamster V79-4 cells. Heat-inactivated serum was used because of the possibility that a serum component may interfere with TPA ability to cause SCE. TPA effect on SCE was determined at the first and second division post treatment on cells exposed to different 5-bromodeoxyuridine (BrdUrd) concentrations. Independent of BrdUrd concentration (1-10μg/ml medium) and the number of cells divisions post treatment, TPA (0.01-2μg/ml medium) was ineffective in inducing SCE in exponentially and stationary HEC cultures cultivated in medium supplemented with heat-inactivated serum. Also, TPA did not increase the SCE frequency in V79-4 Chinese hamster cells cultured in heat-activated or noninactivated serum. Although SCE induction, a cellular response to carcinogen-induced DNA damage, may be important for the induction of transformation by environmental agents, the enhancement of transformation frequency caused by TPA occurs without further DNA alterations involved in SCE formation

Air Emission Reduction Benefits of Biogas Electricity Generation at Municipal Wastewater Treatment Plants.

Science.gov (United States)

Gingerich, Daniel B; Mauter, Meagan S

2018-02-06

Conventional processes for municipal wastewater treatment facilities are energy and materially intensive. This work quantifies the air emission implications of energy consumption, chemical use, and direct pollutant release at municipal wastewater treatment facilities across the U.S. and assesses the potential to avoid these damages by generating electricity and heat from the combustion of biogas produced during anaerobic sludge digestion. We find that embedded and on-site air emissions from municipal wastewater treatment imposed human health, environmental, and climate (HEC) damages on the order of $1.63 billion USD in 2012, with 85% of these damages attributed to the estimated consumption of 19 500 GWh of electricity by treatment processes annually, or 0.53% of the US electricity demand. An additional 11.8 million tons of biogenic CO 2 are directly emitted by wastewater treatment and sludge digestion processes currently installed at plants. Retrofitting existing wastewater treatment facilities with anaerobic sludge digestion for biogas production and biogas-fueled heat and electricity generation has the potential to reduce HEC damages by up to 24.9% relative to baseline emissions. Retrofitting only large plants (>5 MGD), where biogas generation is more likely to be economically viable, would generate HEC benefits of $254 annually. These findings reinforce the importance of accounting for use-phase embedded air emissions and spatially resolved marginal damage estimates when designing sustainable infrastructure systems.

Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting: A Comparative Study From Sudan

Directory of Open Access Journals (Sweden)

Alaa A.M. Osman

2018-05-01

Full Text Available Purpose: Chemotherapy-induced nausea and vomiting (CINV is a distressing adverse effect. Neurokinin-1 receptor antagonist (NK1RA–containing regimens are the standard regimens for CINV prophylaxis in patients with cancer receiving highly or moderately emetogenic chemotherapy (HEC or MEC. NK1RA agents are expensive and were not registered in Sudan. Recently, regimens containing olanzapine, the available and affordable medication in Sudan, were introduced as another option. This study aimed to compare the efficacy of an olanzapine-containing regimen with the antiemetic regimen that was currently used in our institute for CINV prophylaxis in HEC/MEC settings. Patients and Methods: The study prospectively compared an olanzapine-containing regimen (acute phase: olanzapine, ondansetron, dexamethasone; delayed phase: olanzapine, ondansetron with an ondansetron/dexamethasone regimen (acute phase: ondansetron, dexamethasone; delayed phase: ondansetron in adult patients with cancer receiving HEC or MEC. The study outcomes were complete response (CR; no emesis and no rescue medications and nausea control (no nausea, which were assessed in the acute (0 to 24 hours, delayed (24 to 120 hours, and overall (0 to 120 hours phases. Results: The study included 131 patients (olanzapine-containing: 50 patients; ondansetron/dexamethasone: 81 patients. CR and nausea control were higher in the olanzapine-containing than in the ondansetron/dexamethasone regimen (CR: acute phase, 86% v 71.6%; P = .086; delayed phase, 72% v 30.9%; P < .001; overall phase, 66% v 25.9%; P < .001; nausea control: acute phase, 86% v 74.1%; P = .127; delayed phase, 76% v 34.6%; P < .001; overall phase, 72% v 29.6%; P < .001. The major toxicity of olanzapine was grade 1 and 2 sedation or drowsiness (25 patients. Conclusion: An olanzapine-containing regimen has better efficacy for prevention of CINV in the HEC/MEC setting. Oncologists working in a limited-resource setting should be familiar

Chloroacetaldehyde-induced mutagenesis in Escherichia coli: The role of AlkB protein in repair of 3,N4-ethenocytosine and 3,N4-α-hydroxyethanocytosine

International Nuclear Information System (INIS)

Maciejewska, Agnieszka M.; Ruszel, Karol P.; Nieminuszczy, Jadwiga; Lewicka, Joanna; Sokolowska, Beata; Grzesiuk, Elzbieta; Kusmierek, Jaroslaw T.

2010-01-01

Etheno (ε) adducts are formed in reaction of DNA bases with various environmental carcinogens and endogenously created products of lipid peroxidation. Chloroacetaldehyde (CAA), a metabolite of carcinogen vinyl chloride, is routinely used to generate ε-adducts. We studied the role of AlkB, along with AlkA and Mug proteins, all engaged in repair of ε-adducts, in CAA-induced mutagenesis. The test system used involved pIF102 and pIF104 plasmids bearing the lactose operon of CC102 or CC104 origin (Cupples and Miller (1989) ) which allowed to monitor Lac + revertants, the latter arose by GC → AT or GC → TA substitutions, respectively, as a result of modification of guanine and cytosine. The plasmids were CAA-damaged in vitro and replicated in Escherichia coli of various genetic backgrounds. To modify the levels of AlkA and AlkB proteins, mutagenesis was studied in E. coli cells induced or not in adaptive response. Formation of εC proceeds via a relatively stable intermediate, 3,N 4 -α-hydroxyethanocytosine (HEC), which allowed to compare repair of both adducts. The results indicate that all three genes, alkA, alkB and mug, are engaged in alleviation of CAA-induced mutagenesis. The frequency of mutation was higher in AlkA-, AlkB- and Mug-deficient strains in comparison to alkA + , alkB + , and mug + controls. Considering the levels of CAA-induced Lac + revertants in strains harboring the pIF plasmids and induced or not in adaptive response, we conclude that AlkB protein is engaged in the repair of εC and HEC in vivo. Using the modified TTCTT 5-mers as substrates, we confirmed in vitro that AlkB protein repairs εC and HEC although far less efficiently than the reference adduct 3-methylcytosine. The pH optimum for repair of HEC and εC is significantly different from that for 3-methylcytosine. We propose that the protonated form of adduct interact in active site of AlkB protein.

NEPA, a new fixed combination of netupitant and palonosetron, is a cost-effective intervention for the prevention of chemotherapy-induced nausea and vomiting in the UK

Directory of Open Access Journals (Sweden)

Helene Cawston

2017-03-01

Full Text Available Background: The objective was to evaluate the cost-effectiveness of NEPA, an oral fixed combination netupitant (NETU, 300 mg and palonosetron (PA, 0.5 mg compared with aprepitant and palonosetron (APPA or palonosetron (PA alone, to prevent chemotherapy-induced nausea and vomiting (CINV in patients undergoing treatment with highly or moderately emetogenic chemotherapy (HEC or MEC in the UK. Scope: A systematic literature review and meta-analysis were undertaken to compare NEPA with currently recommended anti-emetics. Relative effectiveness was estimated over the acute (day 1 and overall treatment (days 1–5 phases, taking complete response (CR, no emesis and no rescue medication and complete protection (CP, CR and no more than mild nausea [VAS scale <25 mm] as primary efficacy outcomes. A three-health-state Markov cohort model, including CP, CR and incomplete response (no CR for HEC and MEC, was constructed. A five-day time horizon and UK NHS perspective were adopted. Transition probabilities were obtained by combining the response rates of CR and CP from NEPA trials and odds ratios from the meta-analysis. Utilities of 0.90, 0.70 and 0.24 were defined for CP, CR and incomplete response, respectively. Costs included medications and management of CINV-related events and were obtained from the British National Formulary and NHS Reference Costs. The expected budgetary impact of NEPA was also evaluated. Findings: In HEC patients, the NEPA strategy was more effective than APPA (quality-adjusted life days [QALDs] of 4.263 versus 4.053; incremental emesis-free and CINV-free days of +0.354 and +0.237, respectively and was less costly (£80 versus £124, resulting in NEPA being the dominant strategy. In MEC patients, NEPA was cost effective, cumulating in an estimated 0.182 extra QALDs at an incremental cost of £6.65 compared with PA. Conclusion: Despite study limitations (study setting, time horizon, utility measure, the results suggest NEPA is cost

An Operational Short-Term Forecasting System for Regional Hydropower Management

Science.gov (United States)

Gronewold, A.; Labuhn, K. A.; Calappi, T. J.; MacNeil, A.

2017-12-01

The Niagara River is the natural outlet of Lake Erie and drains four of the five Great lakes. The river is used to move commerce and is home to both sport fishing and tourism industries. It also provides nearly 5 million kilowatts of hydropower for approximately 3.9 million homes. Due to a complex international treaty and the necessity of balancing water needs for an extensive tourism industry, the power entities operating on the river require detailed and accurate short-term river flow forecasts to maximize power output. A new forecast system is being evaluated that takes advantage of several previously independent components including the NOAA Lake Erie operational Forecast System (LEOFS), a previously developed HEC-RAS model, input from the New York Power Authority(NYPA) and Ontario Power Generation (OPG) and lateral flow forecasts for some of the tributaries provided by the NOAA Northeast River Forecast Center (NERFC). The Corps of Engineers updated the HEC-RAS model of the upper Niagara River to use the output forcing from LEOFS and a planned Grass Island Pool elevation provided by the power entities. The entire system has been integrated at the NERFC; it will be run multiple times per day with results provided to the Niagara River Control Center operators. The new model helps improve discharge forecasts by better accounting for dynamic conditions on Lake Erie. LEOFS captures seiche events on the lake that are often several meters of displacement from still water level. These seiche events translate into flow spikes that HEC-RAS routes downstream. Knowledge of the peak arrival time helps improve operational decisions at the Grass Island Pool. This poster will compare and contrast results from the existing operational flow forecast and the new integrated LEOFS/HEC-RAS forecast. This additional model will supply the Niagara River Control Center operators with multiple forecasts of flow to help improve forecasting under a wider variety of conditions.

Integrating Satellite Image Identification and River Routing Simulation into the Groundwater Simulation of Chou-Shui Basin

Science.gov (United States)

Yao, Y.; Yang, S.; Chen, Y.; Chang, L.; Chiang, C.; Huang, C.; Chen, J.

2012-12-01

Many groundwater simulation models have been developed for Chou-Shui River alluvial fan which is one of the most important groundwater areas in Taiwan. However, the exchange quantity between Chou-Shui River, the major river in this area, and the groundwater system itself is seldom studied. In this study, the exchange is evaluated using a river package (RIV) in the groundwater simulation model, MODFLOW 2000. Several critical parameters and variables used in RIV such as wet area and river level for each cell below the Chou-Shui River are respectively determined by satellite image identification and HEC-RAS simulation. The monthly average of river levels obtained from four stations include Chang-Yun Bridge, Xi-Bin Bridge, Chi-Chiang Bridge and Si-Jou Bridge during 2008 and the river cross-section measured on December 2007 are used in the construction of HEC-RAS model. Four FORMOSAT multispectral satellite images respectively obtained on January 2008, April 2008, July 2008, and November 2008 are used to identify the wet area of Chou-Shui River during different seasons. Integrating the simulation level provided by HEC-RAS and the identification result are used as the assignment of RIV. First, based on the simulation results of HEC-RAS, the water level differences between flooding period and draught period are 1.4 (m) and 2.0 (m) for Xi-Bin Bridge station (downstream) and Chang-Yun Bridge station (upstream) respectively. Second, based on the identified results, the wet areas for four seasons are 24, 24, 40 and 12 (km2) respectively. The variation range of areas in 2008 is huge that the area for winter is just 30% of the area for summer. Third, based on the simulation of MODFLOW 2000 and RIV, the exchange between the river and the groundwater system is 414 million cubic meters which contains 526 for recharge to river and 112 for discharging from river during 2008. The total recharge includes river exchange and recharge from non-river area is 2023 million cubic meters. The

Application of Virtual Rain and Stream Gauge Information Service for Improved Flood Early Warning System in Lower Mekong Countries

Science.gov (United States)

Basnayake, S. B.; Jayasinghe, S.; Meechaiya, C.; Markert, K. N.; Lee, H.; Towashiraporn, P.; Anderson, E.; Okeowo, M. A.

2017-12-01

Asia is the most vulnerable region in the world to hydro-meteorological extreme events, exacerbated by climate variability and change. Impacts of floods have been on the rapid increase in the recent decades. Myanmar is one of the most vulnerable countries in the lower Mekong region due to its socioeconomic situation (eg; Nargis in 2008, monsoon floods in 2015, etc). Early warning is an effective way to prepare for hydro-meteorological hazards, to minimize disaster risks; however, early warning systems in Myanmar are seriously hampered by limited observation networks. The Virtual Rain and Stream Gauge Information Service (VRSGIS) has been developed by SERVIR-Mekong program of Asian Disaster Preparedness Center (ADPC) to address these gaps and to provide dense, satellite-based rainfall and water level data, which are calibrated and validated with available in-situ observations. This service would enhance decision making in lower Mekong countries, including Myanmar, to minimize impacts of impending disasters. This service contains rainfall data from GPM IMERG and GSMap, CMORPH, TRMM, and CHIRPS, and water levels for 15 locations using Jason-2/3 altimetry. The virtual daily rainfall data sets are being calibrated with Gamma distribution method and are made publicly accessible through a user-friendly web interface.This paper presents a case study of satellite-derived rainfall data accessed from VRSGIS for hydrological modeling in Myanmar, to estimate inundation areas in Kalay township area of Chindwin River basin during the country's worst flood in 2015. Twelve out of fourteen States of Myanmar were severely affected, 103 people were killed, and one million were displaced due to heavy rains associated with Komen cyclone. The aforementioned rainfall data products are used as inputs for HEC-HMS hydrological runoff model to calculate river flows along Chindwin River, and HEC-RAS hydraulic model is used to estimate inundation areas in downstream including Kalay township

Research on Multi Hydrological Models Applicability and Modelling Data Uncertainty Analysis for Flash Flood Simulation in Hilly Area

Science.gov (United States)

Ye, L.; Wu, J.; Wang, L.; Song, T.; Ji, R.

2017-12-01

Flooding in small-scale watershed in hilly area is characterized by short time periods and rapid rise and recession due to the complex underlying surfaces, various climate type and strong effect of human activities. It is almost impossible for a single hydrological model to describe the variation of flooding in both time and space accurately for all the catchments in hilly area because the hydrological characteristics can vary significantly among different catchments. In this study, we compare the performance of 5 hydrological models with varying degrees of complexity for simulation of flash flood for 14 small-scale watershed in China in order to find the relationship between the applicability of the hydrological models and the catchments characteristics. Meanwhile, given the fact that the hydrological data is sparse in hilly area, the effect of precipitation data, DEM resolution and their interference on the uncertainty of flood simulation is also illustrated. In general, the results showed that the distributed hydrological model (HEC-HMS in this study) performed better than the lumped hydrological models. Xinajiang and API models had good simulation for the humid catchments when long-term and continuous rainfall data is provided. Dahuofang model can simulate the flood peak well while the runoff generation module is relatively poor. In addition, the effect of diverse modelling data on the simulations is not simply superposed, and there is a complex interaction effect among different modelling data. Overall, both the catchment hydrological characteristics and modelling data situation should be taken into consideration in order to choose the suitable hydrological model for flood simulation for small-scale catchment in hilly area.

Comparative Study of Antimicrobial Activity of AgBr and Ag Nanoparticles (NPs)

Science.gov (United States)

Suchomel, Petr; Kvitek, Libor; Panacek, Ales; Prucek, Robert; Hrbac, Jan; Vecerova, Renata; Zboril, Radek

2015-01-01

The diverse mechanism of antimicrobial activity of Ag and AgBr nanoparticles against gram-positive and gram-negative bacteria and also against several strains of candida was explored in this study. The AgBr nanoparticles (NPs) were prepared by simple precipitation of silver nitrate by potassium bromide in the presence of stabilizing polymers. The used polymers (PEG, PVP, PVA, and HEC) influence significantly the size of the prepared AgBr NPs dependently on the mode of interaction of polymer with Ag+ ions. Small NPs (diameter of about 60–70 nm) were formed in the presence of the polymer with low interaction as are PEG and HEC, the polymers which interact with Ag+ strongly produce nearly two times bigger NPs (120–130 nm). The prepared AgBr NPs were transformed to Ag NPs by the reduction using NaBH4. The sizes of the produced Ag NPs followed the same trends – the smallest NPs were produced in the presence of PEG and HEC polymers. Prepared AgBr and Ag NPs dispersions were tested for their biological activity. The obtained results of antimicrobial activity of AgBr and Ag NPs are discussed in terms of possible mechanism of the action of these NPs against tested microbial strains. The AgBr NPs are more effective against gram-negative bacteria and tested yeast strains while Ag NPs show the best antibacterial action against gram-positive bacteria strains. PMID:25781988

A bipartite signal mediates the transfer of type IV secretion substrates of Bartonella henselae into human cells.

Science.gov (United States)

Schulein, Ralf; Guye, Patrick; Rhomberg, Thomas A; Schmid, Michael C; Schröder, Gunnar; Vergunst, Annette C; Carena, Ilaria; Dehio, Christoph

2005-01-18

Bacterial type IV secretion (T4S) systems mediate the transfer of macromolecular substrates into various target cells, e.g., the conjugative transfer of DNA into bacteria or the transfer of virulence proteins into eukaryotic host cells. The T4S apparatus VirB of the vascular tumor-inducing pathogen Bartonella henselae causes subversion of human endothelial cell (HEC) function. Here we report the identification of multiple protein substrates of VirB, which, upon translocation into HEC, mediate all known VirB-dependent cellular changes. These Bartonella-translocated effector proteins (Beps) A-G are encoded together with the VirB system and the T4S coupling protein VirD4 on a Bartonella-specific pathogenicity island. The Beps display a modular architecture, suggesting an evolution by extensive domain duplication and reshuffling. The C terminus of each Bep harbors at least one copy of the Bep-intracellular delivery domain and a short positively charged tail sequence. This biparte C terminus constitutes a transfer signal that is sufficient to mediate VirB/VirD4-dependent intracellular delivery of reporter protein fusions. The Bep-intracellular delivery domain is also present in conjugative relaxases of bacterial conjugation systems. We exemplarily show that the C terminus of such a conjugative relaxase mediates protein transfer through the Bartonella henselae VirB/VirD4 system into HEC. Conjugative relaxases may thus represent the evolutionary origin of the here defined T4S signal for protein transfer into human cells.

Studi Angkutan Sedimen Sudetan Pelangwot-Sedayu Lawas Sungai Bengawan Solo

Directory of Open Access Journals (Sweden)

Chandra Murprabowo Mudjib

2013-12-01

Full Text Available Sungai Bengawan Solo merupakan salah satu sungai terpanjang di Indonesia yang mengalir mulai dari area hulu di Kabupaten Wonogiri dan Ponorogo hingga ke area hilir di Kabupaten Gresik. Perubahan fungsi lahan di area hulu dan peningkatan debit yang melalui Sungai Bengawan Solo membuat banjir terjadi di area hilir sungai yakni di Kabupaten Bojonegoro dan Kabupaten Gresik. Sudetan Pelangwot sepanjang 13 km merupakan saluran yang dibuat untuk mengurangi debit banjir yang terjadi dengan mengalirkannya ke laut Jawa. Namun dikarenakan pendangkalan yang terjadi akibat sedimentasi, kapasitas Sudetan Pelangwot dalam mengalirkan debit menurun. Tugas akhir ini bertujuan untuk menganalisa sedimentasi yang terjadi pada sudetan Pelangwot dengan menggunakan program bantu HEC-RAS 4.1.0 Konsep yang digunakan dalam pengerjaan tugas akhir ini adalah dengan memodelkan Sudetan Pelangwot menggunakan program HEC-RAS 4.1.0 kemudian melakukan simulasi aliran sudetan untuk mengetahui sedimentasi yang terjadi. Dari hasil simulasi yang dilakukan dengan menggunakan program HEC-RAS 4.1.0 diketahui perkiraan volume sedimentasi yang terjadi di sudetan selama musim penghujan dari tanggal 1 Desember 2010 hingga 21 Mei 2011 adalah sebesar 325.030,23 m3. Agradasi terjadi di sebagian besar penampang sudetan sedangkan degradasi hanya terjadi di beberapa titik. Kantong sedimen dapat dibuat sebagai upaya pengendalian sedimen pada dasar saluran sudetan di tiga titik yang berbeda dengan kapasitas total 175.875 m3.Pemeliharaan kantong sedimen dilakukan setiap 3 bulan sekali dengan melakukan pengerukan pada kantong sedimen.

A description of the nearshore fish communities in the Huron-Erie Corridor using multiple gear types

Science.gov (United States)

Francis, James T.; Chiotti, Justin A.; Boase, James C.; Thomas, Mike V.; Manny, Bruce A.; Roseman, Edward F.

2013-01-01

Great Lakes coastal wetlands provide a critical habitat for many fish species throughout their life cycles. Once home to one of the largest wetland complexes in the Great Lakes, coastal wetlands in the Huron–Erie Corridor (HEC) have decreased dramatically since the early 1900s. We characterized the nearshore fish communities at three different wetland complexes in the HEC using electrofishing, seines, and fyke nets. Species richness was highest in the Detroit River (63), followed by the St. Clair Delta (56), and Western Lake Erie (47). The nearshore fish communities in the Detroit River and St. Clair Delta consisted primarily of shiners, bluntnose minnow, centrarchids, and brook silverside, while the Western Lake Erie sites consisted of high proportions of non-native taxa including common carp, gizzard shad, goldfish, and white perch. Species richness estimates using individual-based rarefaction curves were higher when using electrofishing data compared to fyke nets or seine hauls at each wetland. Twelve fish species were captured exclusively during electrofishing assessments, while one species was captured exclusively in fyke nets, and none exclusively during seine hauls. Western Lake Erie wetlands were more indicative of degraded systems with lower species richness, lower proportion of turbidity intolerant species, and increased abundance of non-native taxa. This work highlights the importance of coastal wetlands in the HEC by capturing 69 different fish species utilizing these wetlands to fulfill life history requirements and provides insight when selecting gears to sample nearshore littoral areas.

ND:GLASS LASER DESIGN FOR LASER ICF FISSION ENERGY (LIFE)

International Nuclear Information System (INIS)

Caird, J.A.; Agrawal, V.; Bayramian, A.; Beach, R.; Britten, J.; Chen, D.; Cross, R.; Ebbers, C.; Erlandson, A.; Feit, M.; Freitas, B.; Ghosh, C.; Haefner, C.; Homoelle, D.; Ladran, T.; Latkowski, J.; Molander, W.; Murray, J.; Rubenchik, S.; Schaffers, K.; Siders, C.W.; Stappaerts, E.; Sutton, S.; Telford, S.; Trenholme, J.; Barty, C.J.

2008-01-01

We have developed preliminary conceptual laser system designs for the Laser ICF (Inertial Confinement Fusion) Fission Energy (LIFE) application. Our approach leverages experience in high-energy Nd:glass laser technology developed for the National Ignition Facility (NIF), along with high-energy-class diode-pumped solid-state laser (HEC-DPSSL) technology developed for the DOE's High Average Power Laser (HAPL) Program and embodied in LLNL's Mercury laser system. We present laser system designs suitable for both indirect-drive, hot spot ignition and indirect-drive, fast ignition targets. Main amplifiers for both systems use laser-diode-pumped Nd:glass slabs oriented at Brewster's angle, as in NIF, but the slabs are much thinner to allow for cooling by high-velocity helium gas as in the Mercury laser system. We also describe a plan to mass-produce pump-diode lasers to bring diode costs down to the order of $0.01 per Watt of peak output power, as needed to make the LIFE application economically attractive

Probable maximum flood analysis, Richton Dome, Mississippi-Phase I: Technical report

International Nuclear Information System (INIS)

1987-03-01

This report presents results of a preliminary analysis of the extent of inundation that would result from a probable maximum flood (PMF) event in the overdome area of Richton Dome, Mississippi. Bogue Homo and Thompson Creek watersheds drain the overdome area. The US Army Corps of Engineers' HEC-1 Flood Hydrograph Package was used to calculate runoff hydrographs, route computed flood hydrographs, and determine maximum flood stages at cross sections along overdome tributaries. The area and configuration of stream cross sections were determined from US Geological Survey topographic maps. Using maximum flood stages calculated by the HEC-1 analysis, areas of inundation were delineated on 10-ft (3-m) contour interval topographic maps. Approximately 10% of the overdome area, or 0.9 mi 2 (2 km 2 ), would be inundated by a PMF event. 34 refs., 3 figs., 1 tab

Microstrip gas chamber on thin-film Pestov glass and micro gap chamber

International Nuclear Information System (INIS)

Gong, W.G.; Harris, J.W.; Wieman, H.

1994-07-01

The authors report developments of the Microstrip Gas Chamber on thin-film Pestov glass and the Micro Gap Chamber. By coating a thin-layer of low-resistive, electronically-conductive glass on various substrates (including quartz and ceramics), they built MSGCs of high gain stability and low leakage current. They were tested in Ar-CH 4 (10%) and He-C 2 H 6 (50%) gas mixtures. Energy resolutions of 17-20% were measured for 6keV x-rays. This design can make the choice of substrate less important, save the cost of ion-implantation, and use less glass material. Micro Gap Chamber was successfully tested in He-C 2 H 6 (50%) and Ar-C 2 H 6 (50%) gas mixtures. Energy resolutions of about 20% were obtained. Both detectors are expected to have high rate capability

Updating HEC-18 pier scour equations for noncohesive soils.

Science.gov (United States)

2016-10-01

A dataset of 594 bridge pier scour observations from two laboratory and three field studies was compiled. The dataset served as the testing ground for evaluating potential enhancements to the pier scour tools for noncohesive soils in Hydraulic Engine...

ATLAS HEC Photographs - Pictures of the TRIUMF Production Site

CERN Multimedia

Wielers, M.

2000-01-01

Photo 1 - Arrival of Copper Plates Photo 2 - Cleaning of Copper Plates Photo 3 - Stacking Clean Room Photo 4 - Glue Press used for PAD Board Production Photo 5 - Cut honeycomb being removed from Steel Rule Die Photo 6 - Brake Press

A model study of bridge hydraulics : technical summary.

Science.gov (United States)

2010-08-01

Most flood studies in the United States use the Army Corps of Engineers Hydrologic Engineering Centers River Analysis System (HEC-RAS) computer program. This report is the second edition. The first edition of the report considered the laboratory m...

Assessment and mapping of flood potential in the Sl˘anic catchment ...

Indian Academy of Sciences (India)

2National Institute of Hydrology and Water Management, Sos. Bucuresti-Ploiesti 97, .... the HEC-RAS open source software (Devon 2003;. Brazdil et al. 2006 ...... in the universal soil loss equation, In: Assessment of Ero- sion (eds) De Boodt ...

Swift fox survey along Heartland Expressway Corridor.

Science.gov (United States)

2015-05-01

The swift fox (Vulpes velox) is a small canid classified as endangered within the : state of Nebraska. Future construction of the Heartland Expressway Corridor (HEC), a : 300 km road expansion project in the panhandle of the state, may impact the res...

Co adaptation of LiCl tolerant Solanum tuberosum L. callus cultures ...

African Journals Online (AJOL)

Jane

2011-10-12

Oct 12, 2011 ... also brings about tolerance to osmotic effects of salt. This data is highly .... These RGR values of control and LiCl adapted calli were used as reference .... by the Higher Education Commission (HEC) grants. The technical ...

The use of supersaturation for the vaginal application of microbicides: a case study with dapivirine.

Science.gov (United States)

Grammen, Carolien; Plum, Jakob; Van Den Brande, Jeroen; Darville, Nicolas; Augustyns, Koen; Augustijns, Patrick; Brouwers, Joachim

2014-11-01

In this study, we investigated the potential of supersaturation for the formulation of the poorly water-soluble microbicide dapivirine (DPV) in an aqueous vaginal gel in order to enhance its vaginal tissue uptake. Different excipients such as hydroxypropylmethylcellulose, polyethylene glycol 1000, and cyclodextrins were evaluated for their ability to inhibit precipitation of supersaturated DPV in the formulation vehicle as such as well as in biorelevant media. In vitro permeation assessment across HEC-1A cell layers demonstrated an enhanced DPV flux from supersaturated gels compared with suspension gels. The best performing supersaturated gel containing 500 μM DPV (supersaturation degree of 4) in the presence of sulfobutyl ether-beta-cyclodextrin (2.5%) appeared to be stable for at least 3 months. In addition, the gel generated a significant increase in vaginal drug uptake in rabbits as compared with suspension gels. We conclude that supersaturation is a possible strategy to enhance the vaginal concentration of hydrophobic microbicides, thereby increasing permeation into the vaginal submucosa. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

ANÁLISIS HIDROLÓGICO E HIDRÁULICO DE LA CUENCA DEL RÍO FRÍO, MUNICIPIOS DE CIÉNAGA Y ZONA BANANERA, DEPARTAMENTO DEL MAGDALENA

Directory of Open Access Journals (Sweden)

Alfredo Ramos Moreno

2017-07-01

Full Text Available Los modelos hidrológicos e hidráulicos han permitido grandes avances en los estudios de las cuencas hidrográficas, la utilización de modelos como HEC RAS y HEC HMS los cuales han recibido una gran acogida por la comunidad mundial de ingenieros que se desempeñan en el área de la meteorología, hidrología, hidráulica y otras áreas relacionadas con el manejo del recurso hídrico. Gracias a sus grandes aproximaciones los modelos de HEC RAS y HEC HMS fueron seleccionados para realizar las modelaciones para determinar el comportamiento hidrológico e hidráulico de la cuenca del río Frío ubicada en el municipio de Zona Bananera, departamento del Magdalena como producto de las inundaciones que se han presentado en los últimos años. En este artículo se expone una cantidad de análisis cuantitativos y cualitativos que posibilitan la obtención de la información de entrada de los modelos de simulación, posteriormente, dicha información fue introducida a los modelos para lograr determinar el comportamiento bajo escenarios extremos a los que la cuenca del río Frío puede ser sometida. De acuerdo con los resultados obtenidos las áreas donde se presentan los principales inconvenientes de carácter hidráulico e hidrológico, se deben principalmente a la configuración geométrica de la batimetría del río y al desarrollo de actividades agrícolas y ganaderas que han generado cambios en el uso del suelo, modificando los números de curva y aumentando la escorrentía hacia los afluentes y finalmente hacia el río principal. Frente a esta situación se relacionan una serie de recomendaciones que buscan corregir el régimen hidrológico y comportamiento hidrodinámico para evitar nuevas inundaciones que pongan en riesgo a la población que se encuentra en las inmediaciones del río Frío en el municipio de la Zona Bananera Departamento del Magdalena.

Status report on electron cyclotron resonance ion sources at the Heavy Ion Medical Accelerator in Chiba

CERN Document Server

Kitagawa, A; Sekiguchi, M; Yamada, S; Jincho, K; Okada, T; Yamamoto, M; Hattori, T G; Biri, S; Baskaran, R; Sakata, T; Sawada, K; Uno, K

2000-01-01

The Heavy Ion Medical Accelerator in Chiba at the National Institute of Radiological Sciences (NIRS) is not only dedicated to cancer therapy, it is also utilized with various ion species for basic experiments of biomedical science, physics, chemistry, etc. Two electron cyclotron resonance (ECR) ion sources are installed for production of gaseous ions. One of them, the NIRS-ECR, is a 10 GHz ECR ion source, and is mainly operated to produce C/sup 4+/ ions for daily clinical treatment. This source realizes good reproducibility and reliability and it is easily operated. The other source, the NIRS-HEC, is an 18 GHz ECR ion source that is expected to produce heavier ion species. The output ion currents of the NIRS-ECR and the NIRS-HEC are 430e mu A for C/sup 4+/ and 1.1e mA for Ar/sup 8+/, respectively. (14 refs).

Erratum to: Elephants also like coffee: Trends and drivers of human-elephant conflicts in coffee agroforestry landscapes of Kodagu, Western Ghats, India.

Science.gov (United States)

Bal, P; Nath, C D; Nanaya, K M; Kushalappa, C G; Garcia, C

2011-08-01

Kodagu district produces 2% of the world's coffee, in complex, multistoried agroforestry systems. The forests of the district harbour a large population of the Asian elephant (Elephas maximus). The combined effects of high elephant density and major landscape changes due to the expansion of coffee cultivation are the cause of human-elephant conflicts (HEC). Mitigation strategies, including electric fences and compensation schemes implemented by the Forest Department have met with limited success. Building on previous studies in the area, we assessed current spatial and temporal trends of conflict, analysed local stakeholders' perceptions and identified factors driving elephants into the estates. Our study, initiated in May 2007, shows that the intensity of HEC has increased over the last 10 years, exhibiting new seasonal patterns. Conflict maps and the lack of correlation between physical features of the coffee plantations and elephant visits suggest elephants move along corridors between the eastern and western forests of the district, opportunistically foraging when crossing the plantations. Dung analyses indicate elephants have selectively included ripe coffee berries in their diet. This is, to our knowledge, the first report of wild elephants feeding on coffee berries. If this new behaviour spreads through the population, it will compound an already severe conflict situation. The behavioural plasticity, the multiplicity of stakeholders involved, the difficulty in defining the problem and the limits of technical solutions already proposed suggest that HEC in Kodagu has the ingredients of a "wicked" problem whose resolution will require more shared understanding and problem solving work amongst the stakeholders.

Elephants also like coffee: trends and drivers of human-elephant conflicts in coffee agroforestry landscapes of Kodagu, Western Ghats, India.

Science.gov (United States)

Bal, P; Nath, C D; Nanaya, K M; Kushalappa, C G; Garcia, C

2011-05-01

Kodagu district produces 2% of the world's coffee, in complex, multistoried agroforestry systems. The forests of the district harbour a large population of the Asian elephant (Elephas maximus). The combined effects of high elephant density and major landscape changes due to the expansion of coffee cultivation are the cause of human-elephant conflicts (HEC). Mitigation strategies, including electric fences and compensation schemes implemented by the Forest Department have met with limited success. Building on previous studies in the area, we assessed current spatial and temporal trends of conflict, analysed local stakeholders' perceptions and identified factors driving elephants into the estates. Our study, initiated in May 2007, shows that the intensity of HEC has increased over the last 10 years, exhibiting new seasonal patterns. Conflict maps and the lack of correlation between physical features of the coffee plantations and elephant visits suggest elephants move along corridors between the eastern and western forests of the district, opportunistically foraging when crossing the plantations. Dung analyses indicate elephants have selectively included ripe coffee berries in their diet. This is, to our knowledge, the first report of wild elephants feeding on coffee berries. If this new behaviour spreads through the population, it will compound an already severe conflict situation. The behavioural plasticity, the multiplicity of stakeholders involved, the difficulty in defining the problem and the limits of technical solutions already proposed suggest that HEC in Kodagu has the ingredients of a "wicked" problem whose resolution will require more shared understanding and problem solving work amongst the stakeholders.

Safety assessment of thiolated polymers: effect on ciliary beat frequency in human nasal epithelial cells.

Science.gov (United States)

Palmberger, Thomas F; Augustijns, Patrick; Vetter, Anja; Bernkop-Schnürch, Andreas

2011-12-01

The aim of this study was to investigate the nasal safety of gel formulations of thiolated polymers (thiomers) by assessing their effect on ciliary beat frequency (CBF) in human nasal epithelial cells. Poly(acrylic acid) 450 kDa-cysteine (PAA-cys) and alginate-cysteine (alg-cys) were synthesized by covalent attachment of L-cysteine to the polymeric backbone. The cationic polymer chitosan-thiobutylamidine (chito-TBA) was synthesized by attaching iminothiolane to chitosan. CBF using was measured by a photometric system. CBF was measured before incubating the cells with test gels, during incubation and after washing out the polymeric test gels to evaluate reversibility of cilio-inhibition. The influence of viscosity on CBF was determined by using hydroxyethylcellulose (HEC)-gels of various concentrations. Ciliary beating was observed to be affected by viscosity, but cilia were still beating in the presence of a HEC-gel displaying an apparent viscosity of 25 Pa.s. In case of thiolated polymers and their unmodified control, a concentration-dependent decrease in CBF could be observed. PAA-cys, alg-cys, chito-TBA and their corresponding unmodified controls exhibited a moderate cilio-inhibitory effect, followed by a partial recovery of CBF when used at a concentration of 1%. Alg-cys 2% and chito-TBA 2% (m/v) gels exhibited severe cilio-inhibition, which was partially reversible. L-cysteine and reduced glutathione led to mild cilio-inhibition at concentrations of 3% (m/v). Taking into account that dilution after application and cilio-modifying effects is usually more pronounced under in vitro conditions, thiomers can be considered as suitable excipients for nasal drug delivery systems.

Calibration and Verification of the Hydraulic Model for Blue Nile River from Roseires Dam to Khartoum City

Directory of Open Access Journals (Sweden)

Kamal edin ELsidig Bashar

2015-12-01

Full Text Available This research represents a practical attempt applied to calibrate and verify a hydraulic model for the Blue Nile River. The calibration procedures are performed using the observed data for a previous period and comparing them with the calibration results while verification requirements are achieved with the application of the observed data for another future period and comparing them with the verification results. The study objective covered a relationship of the river terrain with the distance between the assumed points of the dam failures along the river length. The computed model values and the observed data should conform to the theoretical analysis and the overall verification performance of the model by comparing it with another set of data. The model was calibrated using data from gauging stations (Khartoum, Wad Medani, downstream Sennar, and downstream Roseires during the period from the 1st of May to 31 of October 1988 and the verification was done using the data of the same gauging stations for years 2003 and 2010 for the same period. The required available data from these stations were collected, processed and used in the model calibration. The geometry input files for the HEC-RAS models were created using a combination of ArcGIS and HEC-GeoRAS. The results revealed high correlation (R2 ˃ 0.9 between the observed and calibrated water levels in all gauging stations during 1988 and also high correlation between the observed and verification water levels was obtained in years 2003 and 2010. Verification results with the equation and degree of correlation can be used to predict future data of any expected data for the same stations.

Evaluation of multiple hydraulic models in generating design/near-real time flood inundation extents under various geophysical settings

Science.gov (United States)

Liu, Z.; Rajib, M. A.; Jafarzadegan, K.; Merwade, V.

2015-12-01

Application of land surface/hydrologic models within an operational flood forecasting system can provide probable time of occurrence and magnitude of streamflow at specific locations along a stream. Creating time-varying spatial extent of flood inundation and depth requires the use of a hydraulic or hydrodynamic model. Models differ in representing river geometry and surface roughness which can lead to different output depending on the particular model being used. The result from a single hydraulic model provides just one possible realization of the flood extent without capturing the uncertainty associated with the input or the model parameters. The objective of this study is to compare multiple hydraulic models toward generating ensemble flood inundation extents. Specifically, relative performances of four hydraulic models, including AutoRoute, HEC-RAS, HEC-RAS 2D, and LISFLOOD are evaluated under different geophysical conditions in several locations across the United States. By using streamflow output from the same hydrologic model (SWAT in this case), hydraulic simulations are conducted for three configurations: (i) hindcasting mode by using past observed weather data at daily time scale in which models are being calibrated against USGS streamflow observations, (ii) validation mode using near real-time weather data at sub-daily time scale, and (iii) design mode with extreme streamflow data having specific return periods. Model generated inundation maps for observed flood events both from hindcasting and validation modes are compared with remotely sensed images, whereas the design mode outcomes are compared with corresponding FEMA generated flood hazard maps. The comparisons presented here will give insights on probable model-specific nature of biases and their relative advantages/disadvantages as components of an operational flood forecasting system.

Approaching Engagement towards Human-Engaged Computing

DEFF Research Database (Denmark)

Niksirat, Kavous Salehzadeh; Sarcar, Sayan; Sun, Huatong

2018-01-01

Debates regarding the nature and role of HCI research and practice have intensified in recent years, given the ever increasingly intertwined relations between humans and technologies. The framework of Human-Engaged Computing (HEC) was proposed and developed over a series of scholarly workshops to...

Urbanization Impacts on Flooding in the Kansas River Basin and Evaluation of Wetlands as a Mitigation Measure

Science.gov (United States)

This study evaluates the impacts of future land use changes on flooding in the Kansas River Basin. It also studies the impacts of wetlands on flood reduction. The study presents Hydrologic Engineering Centers-Hydrologic Modeling System (HEC-HMS) based runoff modeling and River A...

Designing Roads and Retaining Structures for Nangarhar Province, Afghanistan

Science.gov (United States)

2011-01-01

2010). The province has 9 hospitals and 229 clinics . Water is obtained from ka- rezes, shallow wells, rivers, and springs. Safe drinking water is...compiled into USACE Hydrologic Engineering Center Data Storage System (HEC- DSS ) obtained through National Climatic Data Center (NCDC). and varies ac

THE ASSESSMENT OF ECONOMICAL LOSS CAUSED BY FLOODS AND FLASH-FLOODS BY USING COMPUTER TECHNIQUES. CASE STUDY: LOPĂTARI VILLAGE, SLĂNIC RIVER

Directory of Open Access Journals (Sweden)

COSTACHE R.

2015-03-01

Full Text Available The present study aims to provide an example of the assessment of economical loss caused by floods and flash-floods, by integrating GIS techniques of hydraulic and hydrological modelling. The case study was performed in Lopătari village, which is located in the upper area of Slănic River, one of the most affected areas by floods and flash-floods. The flood event produced on 29.V.2012 was considered in order to perform this study. Thus, a flood hydrograph was simulated by using software HEC-HMS 3.5, based on hourly precipitation data from Bisoca meteorological station from 29.V.2012. The peak discharge resulting from the hydrological modelling software was used in HEC-RAS 4.1 hydraulic modelling software in order to determine the extent of flooding band, the number of the affected elements and the local economical loss. Finally, 21 flooded buildings were identified and 550 m of affected road, the estimated economical damage being about 800,000 RON.

Independent technical review and analysis of hydraulic modeling and hydrology under low-flow conditions of the Des Plaines River near Riverside, Illinois

Science.gov (United States)

Over, Thomas M.; Straub, Timothy D.; Hortness, Jon E.; Murphy, Elizabeth A.

2012-01-01

The U.S. Geological Survey (USGS) has operated a streamgage and published daily flows for the Des Plaines River at Riverside since Oct. 1, 1943. A HEC-RAS model has been developed to estimate the effect of the removal of Hofmann Dam near the gage on low-flow elevations in the reach approximately 3 miles upstream from the dam. The Village of Riverside, the Illinois Department of Natural Resources-Office of Water Resources (IDNR-OWR), and the U. S. Army Corps of Engineers-Chicago District (USACE-Chicago) are interested in verifying the performance of the HEC-RAS model for specific low-flow conditions, and obtaining an estimate of selected daily flow quantiles and other low-flow statistics for a selected period of record that best represents current hydrologic conditions. Because the USGS publishes streamflow records for the Des Plaines River system and provides unbiased analyses of flows and stream hydraulic characteristics, the USGS served as an Independent Technical Reviewer (ITR) for this study.

Controlling The Surface Water of Shatt Al Arab River by using Sluice Gates

Directory of Open Access Journals (Sweden)

Ahmed Naseh Ahmed Hamdan

2016-03-01

Full Text Available The purpose of this study is to find hydrodynamic simulations of river water by controlging gates in Shatt Al Arab river. This river is formed by the meeting of the Tigris and Euphrates rivers near the city of Qurna in the south of Iraq, and it pours into the Arabian Gulf. Hydrodynamic simulations give a proper understanding performance and optimize utilization of the gates controlging the water level. Three different sluice gates opening cases simulate the water surface level using HEC-RAS in Shatt Al Arab river. These cases where being studied within two situations of Tide (the highest high water level and the lowest low water level within the downstream of Shatt Al Arab river. The study also deals with six cases of flow rates in upstream of Shatt Al Arab river. Hec-Ras model is produced by US Army for analyzing river system. This model could simulate steady and unsteady open channel flow.

Creating Flood Inundation Maps For Lower Sakarya River

Directory of Open Access Journals (Sweden)

Osman Sönmez

2013-06-01

Full Text Available The Sakarya River Basin in Turkey frequently floods. The allure of riverside settlement and of nutrient-rich riverbank soil has led to extensive residential and agricultural development in flood plains. In this study, the 100 years return period possible flood carrying capacites of last 113 km of the Lower Sakarya Riverbed were investigated, also dam break and risk analyses were performed by applying different scenarios for the floods likely to occur. Flooding scenarios and water depth within the floodplain during these scenarios were calculated with the HEC-RAS software program and results were converted into a map in HEC-GeoRAS,ArcGIS 9x and ArcView 3.2 programs. As a result, it was observed that the Lower Sakarya River is susceptible to flooding. Recent observations of the study area confirm the study findings. This study tries to underscore the importance of taking into account the different scenarios regarding flood prevention and reduction studies.

Documentation assessment, Project C-018H, 200-E area effluent treatment facility

International Nuclear Information System (INIS)

Peres, M.W.; Connor, M.D.; Mertelendy, J.I.

1994-01-01

Project C-018H is one of the fourteen subprojects to the Hanford Environmental Compliance (HEC) Project. Project C-018H provides treatment and disposal for the 242-A Evaporator and PUREX plant process condensate waste streams. This project used the Integrated Management Team (IMT) approach proposed by RL. The IMT approach included all affected organizations on the project team to coordinate and execute all required project tasks, while striving to integrate and satisfy all technical, operational, functional, and organizational objectives. The HEC Projects were initiated in 1989. Project C-018H began in early 1990, with completion of construction currently targeted for mid-1995. This assessment was performed to evaluate the effectiveness of the management control on design documents and quality assurance records developed and submitted for processing, use, and retention for the Project. The assessment focused primarily on the overall adequacy and quality of the design documentation currently being submitted to the project document control function

Status of the ATLAS Liquid Argon Calorimeter and its performance after one year of LHC operation

CERN Document Server

"Hoffman, J A; The ATLAS collaboration

2011-01-01

The ATLAS experiment is designed to study the proton-proton collisions produced at the LHC with a centre-of-mass energy of 14 TeV. Liquid argon (LAr) sampling calorimeters are used in ATLAS for all electromagnetic calorimetry covering the pseudorapidity region η<3.2, as well as for hadronic calorimetry from η=1.4 to η=4.8. The calorimeter system consists of an electromagnetic barrel calorimeter and two endcaps with electromagnetic (EMEC), hadronic (HEC) and forward (FCAL) calorimeters. The lead-liquid argon sampling technique with an accordion geometry was chosen for the barrel electromagnetic calorimeter (EMB) and adapted to the endcap (EMEC). This geometry allows a uniform acceptance over the whole azimuthal range without any gap. The hadronic endcap calorimeter (HEC) uses a copper-liquid argon sampling technique with plate geometry and is subdivided into two wheels in depth per end-cap. Finally, the forward calorimeter (FCAL) is composed of three modules featuring cylindrical electrodes with thin...

Status of the ATLAS Liquid Argon Calorimeter and its Performance

CERN Document Server

Barillari, T; The ATLAS collaboration

2011-01-01

The ATLAS experiment is designed to study the proton-proton collisions produced at the LHC with a centre-of-mass energy of 14 TeV. Liquid argon (LAr) sampling calorimeters are used in ATLAS for all electromagnetic calorimetry covering the pseudorapidity region |eta|<3.2, as well as for hadronic calorimetry from |eta|=1.4 to |eta|=4.8. The calorimeter system consists of an electromagnetic barrel calorimeter and two endcaps with electromagnetic (EMEC), hadronic (HEC) and forward (FCAL) calorimeters. The lead-liquid argon sampling technique with an accordion geometry was chosen for the barrel electromagnetic calorimeter (EMB) and adapted to the endcap (EMEC). This geometry allows a uniform acceptance over the whole azimuthal range without any gap. The hadronic endcap calorimeter (HEC) uses a copper-liquid argon sampling technique with plate geometry and is subdivided into two wheels in depth per end-cap. Finally, the forward calorimeter (FCAL) is composed of three modules featuring cylindrical electrodes ...

MD simulations of onset of tungsten fuzz formation under helium irradiation

International Nuclear Information System (INIS)

Lasa, A.; Henriksson, K.O.E.; Nordlund, K.

2013-01-01

When helium (He) escapes a fusion reactor plasma, a tungsten (W)-based divertor may, under some conditions, form a fuzz-like nano-morphology. This is a highly undesired phenomenon for the divertor, and is not well understood. We performed molecular dynamics simulations of high fluence He and also C-seeded He (He+C) irradiation on W, focusing on the effect of the high fluence, the temperature and the impurities on the onset of the structure formation. We concluded that MD reproduces the experimentally found square root of time dependence of the surface growth. The He atomic density decreases when increasing the number of He atoms in the cell. A higher temperature causes a larger bubble growth and desorption activity, specially for the pure He irradiation cases. It also it leads to W recrystallization for the He+C irradiation cases. Carbon acts as a local He trap for small clusters or single atoms and causes a larger loss of crystallinity of the W surface

Regulation of matriptase and HAI-1 system, a novel therapeutic target in human endometrial cancer cells.

Science.gov (United States)

Sun, Pengming; Xue, Lifang; Song, Yiyi; Mao, Xiaodan; Chen, Lili; Dong, Binhua; Braicu, Elena Loana; Sehouli, Jalid

2018-02-27

The effects of specific and non-specific regulation of matriptase on endometrial cancer cells in vitro were investigated. Messenger ribonucleic acid (mRNA) and protein expression of matriptase and hepatocyte growth factor activator inhibitor-1 (HAI-1) in RL-952, HEC-1A, and HEC-1B endometrial cancer cells were detected by real-time quantitative PCR (RT-qPCR) and western blot. The cells were infected with lentivirus-mediated small-interfering RNA (siRNA) targeted on matriptase (MA-siRNA) or treated with different cisplatin (DDP) concentrations. After treatment, invasion, migration, and cellular apoptosis were analyzed. Matriptase mRNA and protein expression significantly decreased to 80% after infection with MA-siRNA ( P scratch and trans-well chamber assays showed significant inhibition of invasiveness and metastasis. Upon incubation with cisplatin at concentrations higher than the therapeutic dose for 24 h, the expressions of matriptase and HAI-1 significantly decreased ( P endometrial cancer cells were significantly decreased ( P endometrial cancer cells showed promising therapeutic features.

Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation.

Science.gov (United States)

Solaimani Kartalaei, Parham; Yamada-Inagawa, Tomoko; Vink, Chris S; de Pater, Emma; van der Linden, Reinier; Marks-Bluth, Jonathon; van der Sloot, Anthon; van den Hout, Mirjam; Yokomizo, Tomomasa; van Schaick-Solernó, M Lucila; Delwel, Ruud; Pimanda, John E; van IJcken, Wilfred F J; Dzierzak, Elaine

2015-01-12

Hematopoietic stem cells (HSCs) are generated via a natural transdifferentiation process known as endothelial to hematopoietic cell transition (EHT). Because of small numbers of embryonal arterial cells undergoing EHT and the paucity of markers to enrich for hemogenic endothelial cells (ECs [HECs]), the genetic program driving HSC emergence is largely unknown. Here, we use a highly sensitive RNAseq method to examine the whole transcriptome of small numbers of enriched aortic HSCs, HECs, and ECs. Gpr56, a G-coupled protein receptor, is one of the most highly up-regulated of the 530 differentially expressed genes. Also, highly up-regulated are hematopoietic transcription factors, including the "heptad" complex of factors. We show that Gpr56 (mouse and human) is a target of the heptad complex and is required for hematopoietic cluster formation during EHT. Our results identify the processes and regulators involved in EHT and reveal the surprising requirement for Gpr56 in generating the first HSCs. © 2015 Solaimani Kartalaei et al.

An Investigation of Generic Structures of Pakistani Doctoral Thesis Acknowledgements

Science.gov (United States)

Rofess, Sakander; Mahmood, Muhammad Asim

2015-01-01

This paper investigates Pakistani doctoral thesis acknowledgements from genre analysis perspective. A corpus of 235 PhD thesis acknowledgements written in English was taken from Pakistani doctoral theses collected from eight different disciplines. HEC Research Repository of Pakistan was used as a data sources. The theses written by Pakistani…

Teacher Educators' Evaluation of the English Language Teaching Program: A Turkish Case

Science.gov (United States)

Yavuz, Aysun; Zehir Topkaya, Ece

2013-01-01

This study explored the perceptions of teacher educators regarding the changes in the English Language Teacher Education Program introduced by the Turkish Higher Education Council (HEC) in 2006. Employing a qualitative design, open-ended questionnaires were administered to 18 lecturers working at five different state universities. The analysis of…

Hydrological modeling in semi-arid region using HEC-HMS model ...

African Journals Online (AJOL)

The purpose of this study is to simulate rainfall-runoff in the semi-arid region of ... the frequency storm is used for the meteorological model, the SCS curve number is ... SCS unit hydrograph method have been applied to simulate the runoff rate.

2d river flood modelling using Hec-ras 5.0

OpenAIRE

Flotats Palau, Joan

2016-01-01

Flooding may occur as an overflow of water from water bodies, such as a river, lake or ocean, in which the water overtops or breaks levees, resulting in some of that water escaping its usual boundaries. Floods also occur in rivers when the flow rate exceeds the capacity of the river channel. Floods represent the deadliest natural hazard in Europe, resulting in loss of life, damage to buildings, homes, business and structures such as bridges and roads. Since such consequences ar...

THE USE OF HEC-RAS MODELLING IN FLOOD RISK ANALYSIS

OpenAIRE

IOSUB MARINA; MINEA I.; HAPCIUC OANA; ROMANESCU GH.

2015-01-01

The fact that, in the Ozana drainage basin, most of the people have built their homes in the river valley, determines that a study focused on identifying the areas exposed to hydrological risk is vital, mostly in the development decisions for villages and in the creation of management plans for emergency situations. This study analyses the mapping methodology of the flood prone areas in the middle and lower sector of the Pluton river, which is a tributary of Ozana river, in its upper sector. ...

Aprepitant, granisetron, and dexamethasone versus palonosetron and dexamethasone for prophylaxis of cisplatin-induced nausea and vomiting in patients with upper gastrointestinal cancer: a randomized crossover phase II trial (KDOG 1002).

Science.gov (United States)

Ishido, Kenji; Higuchi, Katsuhiko; Azuma, Mizutomo; Sasaki, Tohru; Tanabe, Satoshi; Katada, Chikatoshi; Yano, Takafumi; Wada, Takuya; Koizumi, Wasaburo

2016-10-01

We conducted a randomized trial to compare the safety and effectiveness of aprepitant, granisetron, and dexamethasone (AGD) with those of palonosetron and dexamethasone (PD) in patients who received highly emetogenic chemotherapy (HEC). Patients with esophageal or gastric cancer who were scheduled to receive HEC including at least 60 mg/m of cisplatin as the first-line treatment were randomly assigned to receive AGD (oral aprepitant 125 mg on day 1 and 80 mg on days 2-3; intravenous granisetron 3 mg on day 1; intravenous dexamethasone 6.6 mg on day 1 and oral dexamethasone 4 mg on days 2-3) or PD (intravenous palonosetron 0.75 mg on day 1; intravenous dexamethasone 13.2 mg on day 1 and oral dexamethasone 8 mg on days 2-3). The primary endpoint was a complete response during the overall study period (0-120 h after the start of chemotherapy) in the first cycle. Eighty-five patients were enrolled, and 84 were eligible. The complete response rate did not differ between the treatment groups, but the proportion of patients with no vomiting was significantly higher in the AGD group than in the PD group (81.4 vs. 58.5%; P=0.031). The results of a quality-of-life survey indicated that the proportion of patients with no or minimal impact on daily life in the vomiting domain was significantly higher in the AGD group (79.1 vs. 53.7%; P=0.020). The primary endpoint of complete response was not achieved, but AGD seems to be more effective than PD for the prevention of HEC-induced vomiting.

Development and characterization of a gastroretentive dosage form composed of chitosan and hydroxyethyl cellulose for alendronate

Directory of Open Access Journals (Sweden)

Chen YC

2013-12-01

Full Text Available Ying-Chen Chen,1,* Hsiu-O Ho,1,* Chiao-Chi Chiu,1 Ming-Thau Sheu1,2 1School of Pharmacy, College of Pharmacy, Taipei Medical University, 2Clinical Research Center and Traditional Herbal Medicine Research Center, Taipei Medical University Hospital, Taipei, Taiwan*These authors contributed equally to this workAbstract: In this study, alendronate, the most commonly used biphosphonate for treating osteoporosis, was formulated as gastroretentive dosage form (GRDF tablets to enhance its oral bioavailability. GRDF tablets were characterized with the effects of different molecular weights (MWs of chitosan (CS and hydroxyethyl cellulose (HEC at various ratios on swelling, floating, and physical integrity. The CS component was formed using various acids: acetic, lactic, malic, succinic, and citric, and a high viscosity grade of HEC was selected. The results demonstrated that the swelling ratios of the formulations comprising high MW CS were lower than those of low or medium MW CS when salts were formed with any countering acids except for acetic acid. The decreasing ranking of the swelling rates was: CS-citrate > CS-malate > CS-lactate > CS-succinate > CS-acetate. A negative correlation was found between the pKa of the respective countering acid and the swelling rate. The swelling rate was promoted if an acidic salt of CS with a lower water content was incorporated, while it became slower when tablet hardness was higher or the compression force to form tablets was increased. Although HEC did not contribute to swelling or floating, it played a role in maintaining structural integrity. A prolonged dissolution profile of alendronate GRDF tablets developed in this study was observed.Keywords: gastroretentive dosage form, chitosan, hydrogel, hydroxyethyl cellulose, swelling, alendronate

Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7.

Science.gov (United States)

Coleman, Leon G; Zou, Jian; Crews, Fulton T

2017-01-25

Toll-like receptor (TLR) signaling is emerging as an important component of neurodegeneration. TLR7 senses viral RNA and certain endogenous miRNAs to initiate innate immune responses leading to neurodegeneration. Alcoholism is associated with hippocampal degeneration, with preclinical studies linking ethanol-induced neurodegeneration with central innate immune induction and TLR activation. The endogenous miRNA let-7b binds TLR7 to cause neurodegeneration. TLR7 and other immune markers were assessed in postmortem human hippocampal tissue that was obtained from the New South Wales Tissue Bank. Rat hippocampal-entorhinal cortex (HEC) slice culture was used to assess specific effects of ethanol on TLR7, let-7b, and microvesicles. We report here that hippocampal tissue from postmortem human alcoholic brains shows increased expression of TLR7 and increased microglial activation. Using HEC slice culture, we found that ethanol induces TLR7 and let-7b expression. Ethanol caused TLR7-associated neuroimmune gene induction and initiated the release let-7b in microvesicles (MVs), enhancing TLR7-mediated neurotoxicity. Further, ethanol increased let-7b binding to the danger signaling molecule high mobility group box-1 (HMGB1) in MVs, while reducing let-7 binding to classical chaperone protein argonaute (Ago2). Flow cytometric analysis of MVs from HEC media and analysis of MVs from brain cell culture lines found that microglia were the primary source of let-7b and HMGB1-containing MVs. Our results identify that ethanol induces neuroimmune pathology involving the release of let-7b/HMGB1 complexes in microglia-derived microvesicles. This contributes to hippocampal neurodegeneration and may play a role in the pathology of alcoholism.

Error of the modelled peak flow of the hydraulically reconstructed 1907 flood of the Ebro River in Xerta (NE Iberian Peninsula)

Science.gov (United States)

Lluís Ruiz-Bellet, Josep; Castelltort, Xavier; Carles Balasch, J.; Tuset, Jordi

2016-04-01

The estimation of the uncertainty of the results of the hydraulic modelling has been deeply analysed, but no clear methodological procedures as to its determination have been formulated when applied to historical hydrology. The main objective of this study was to calculate the uncertainty of the resulting peak flow of a typical historical flood reconstruction. The secondary objective was to identify the input variables that influenced the result the most and their contribution to peak flow total error. The uncertainty of 21-23 October 1907 flood of the Ebro River (NE Iberian Peninsula) in the town of Xerta (83,000 km2) was calculated with a series of local sensitivity analyses of the main variables affecting the resulting peak flow. Besides, in order to see to what degree the result depended on the chosen model, the HEC-RAS resulting peak flow was compared to the ones obtained with the 2D model Iber and with Manning's equation. The peak flow of 1907 flood in the Ebro River in Xerta, reconstructed with HEC-RAS, was 11500 m3·s-1 and its total error was ±31%. The most influential input variable over HEC-RAS peak flow results was water height; however, the one that contributed the most to peak flow error was Manning's n, because its uncertainty was far greater than water height's. The main conclusion is that, to ensure the lowest peak flow error, the reliability and precision of the flood mark should be thoroughly assessed. The peak flow was 12000 m3·s-1 when calculated with the 2D model Iber and 11500 m3·s-1 when calculated with the Manning equation.

Flood Prediction for the Tam Nong District in Mekong Delta Using Hydrological Modelling and Hydrologic Remote Sensing Technique

Science.gov (United States)

Kappas, Martin; Nguyen Hong, Quang; Thanh, Nga Pham Thi; Thu, Hang Le Thi; Nguyen Vu, Giang; Degener, Jan; Rafiei Emam, Ammar

2017-04-01

There has been an increasing attention to the large trans-boundary Mekong river basin due to various problems related to water management and flood control, for instance. Vietnam Mekong delta is located at the downstream of the river basin where is affected most by this human-induced reduction in flows from the upstream. On the other hand, the flood plain of nine anastomosing channels is increasingly effected by the seawater intrusion due to sea level rising of climate change. This results in negative impacts of salinization, drought, and floods, while formerly flooding had frequently brought positive natural gain of irrigation water and alluvial aggradation. In this research, our aim is to predict flooding for the better water management adaptation and control. We applied the model HEC-SSP 2.1 to analyze flood flow frequency, two-dimensional unsteady flow calculations in HEC-RAS 5.0 for simulating a floodplain inundation. Remote sensing-based water level (Jason-2) and inundation map were used for validation and comparison with the model simulations. The results revealed a reduction of water level at all the monitoring stations, particularly in the last decade. In addition, a trend of the inundation extension gradually declined, but in some periods it remained severe due to water release from upstream reservoirs during the rainy season (October-November). We found an acceptable agreement between the HEC-RAS and remote sensing flooding maps (around 70%). Based on the flood routine analysis, we could conclude that the water level will continue lower and lead to a trend of drought and salinization harsher in the near future. Keywords: Mekong delta, flood control, inundation, water management, hydrological modelling, remote sensing

Predicting the occurrence of channelized debris flow by an integrated cascading model: A case study of a small debris flow-prone catchment in Zhejiang Province, China

Science.gov (United States)

Wei, Zhen-lei; Xu, Yue-Ping; Sun, Hong-yue; Xie, Wei; Wu, Gang

2018-05-01

Excessive water in a channel is an important factor that triggers channelized debris flows. Floods and debris flows often occur in a cascading manner, and thus, calculating the amount of runoff accurately is important for predicting the occurrence of debris flows. In order to explore the runoff-rainfall relationship, we placed two measuring facilities at the outlet of a small, debris flow-prone headwater catchment to explore the hydrological response of the catchment. The runoff responses generally consisted of a rapid increase in runoff followed by a slower decrease. The peak runoff often occurred after the rainfall ended. The runoff discharge data were simulated by two different modeling approaches, i.e., the NAM model and the Hydrologic Engineering Center-Hydrologic Modeling System (HEC-HMS) model. The results showed that the NAM model performed better than the HEC-HMS model. The NAM model provided acceptable simulations, while the HEC-HMS model did not. Then, we coupled the calculated results of the NAM model with an empirically based debris flow initiation model to obtain a new integrated cascading disaster modeling system to provide improved disaster preparedness and hazard management. In this case study, we found that the coupled model could correctly predict the occurrence of debris flows. Furthermore, we evaluated the effect of the range of input parameter values on the hydrographical shape of the runoff. We also used the grey relational analysis to conduct a sensitivity analysis of the parameters of the model. This study highlighted the important connections between rainfall, hydrological processes, and debris flow, and it provides a useful prototype model system for operational forecasting of debris flows.

Does des-acyl ghrelin improve glycemic control in obese diabetic subjects by decreasing acylated ghrelin levels?

Science.gov (United States)

Özcan, Behiye; Neggers, Sebastian J C M M; Miller, Anne Reifel; Yang, Hsiu-Chiung; Lucaites, Virginia; Abribat, Thierry; Allas, Soraya; Huisman, Martin; Visser, Jenny A; Themmen, Axel P N; Sijbrands, Eric J G; Delhanty, Patric J D; van der Lely, Aart Jan

2014-06-01

The objective of this study was to assess the effects of a continuous overnight infusion of des-acyl ghrelin (DAG) on acylated ghrelin (AG) levels and glucose and insulin responses to a standard breakfast meal (SBM) in eight overweight patients with type 2 diabetes. Furthermore, in the same patients and two additional subjects, the effects of DAG infusion on AG concentrations and insulin sensitivity during a hyperinsulinemic-euglycemic clamp (HEC) were assessed. A double-blind, placebo-controlled cross-over study design was implemented, using overnight continuous infusions of 3 and 10  μg DAG/kg per h and placebo to study the effects on a SBM. During a HEC, we studied the insulin sensitivity. We observed that, compared with placebo, overnight DAG administration significantly decreased postprandial glucose levels, both during continuous glucose monitoring and at peak serum glucose levels. The degree of improvement in glycemia was correlated with baseline plasma AG concentrations. Concurrently, DAG infusion significantly decreased fasting and postprandial AG levels. During the HEC, 2.5  h of DAG infusion markedly decreased AG levels, and the M-index, a measure of insulin sensitivity, was significantly improved in the six subjects in whom we were able to attain steady-state euglycemia. DAG administration was not accompanied by many side effects when compared with placebo. DAG administration improves glycemic control in obese subjects with type 2 diabetes through the suppression of AG levels. DAG is a good candidate for the development of compounds in the treatment of metabolic disorders or other conditions with a disturbed AG:DAG ratio, such as type 2 diabetes mellitus or Prader-Willi syndrome. © 2014 European Society of Endocrinology.

Effects of fasting on insulin action and glucose kinetics in lean and obese men and women.

Science.gov (United States)

Bergman, Bryan C; Cornier, Marc-Andre; Horton, Tracy J; Bessesen, Daniel H

2007-10-01

The development of insulin resistance in the obese individual could impair the ability to appropriately adjust metabolism to perturbations in energy balance. We investigated a 12- vs. 48-h fast on hepatic glucose production (R(a)), peripheral glucose uptake (R(d)), and skeletal muscle insulin signaling in lean and obese subjects. Healthy lean [n = 14; age = 28.0 +/- 1.4 yr; body mass index (BMI) = 22.8 +/- 0.42] and nondiabetic obese (n = 11; age = 34.6 +/- 2.3 yr; BMI = 36.1 +/- 1.5) subjects were studied following a 12- and 48-h fast during 2 h of rest and a 3-h 40 mUxm(-2)xmin(-1) hyperinsulinemic-euglycemic clamp (HEC). Basal glucose R(a) decreased significantly from the 12- to 48-h fast (lean 1.96 +/- 0.23 to 1.63 +/- 0.15; obese 1.23 +/- 0.07 to 1.07 +/- 0.07 mgxkg(-1)xmin(-1); P = 0.004) and was equally suppressed during the HEC after both fasts. The increase in glucose R(d) during the HEC after the 12-h fast was significantly decreased in lean and obese subjects after the 48-h fast (lean 9.03 +/- 1.17 to 4.16 +/- 0.34, obese 6.10 +/- 0.77 to 3.56 +/- 0.30 mgxkg FFM(-1)xmin(-1); P lean than obese subjects. We conclude that 1) 48 h of fasting produces a marked decline in peripheral insulin action, while suppression of hepatic glucose production is maintained in lean and obese men and women; and 2) the magnitude of this decline is greater in lean vs. obese subjects.

Viscoelastic gravel-pack carrier fluid

International Nuclear Information System (INIS)

Nehmer, W.L.

1988-01-01

The ability of a fluid to flow adequately into the formation during gravel-pack treatments is critical to achieving a good pack. Recent studies have indicated ''fish-eyes'' and/or ''microgels'' present in many polymer gelled carrier fluids will plug pore throats, leading to impaired leakoff and causing formation damage. Intensive manipulation of the polymer gelled fluid using shear and filter devices will help remove the particles, but it adds to the cost of the treatment in terms of equipment and manpower. Excessive shear will degrade the polymer leading to poor gravel suspension, while too little shear will cause filtration problems. A gelled carried fluid using a viscoelastic surfactant system has been found to leak off very efficiently to the formation, and cause no formation damage, without the use of shear/filter devices. Viscoelastic surfactant-base gelled fluids develop viscosity because of the association of surfactant moloecules into large rod-shaped aggregates. There is no hydration of polymer involved, so fish-eyes and microgels will not be formed in the viscoelastic fluid. A surfactant-base system having a yield point allows the gravel carrying properties to be much better than fluids gelled with conventional polymer systems (hydroxyethylcellulose [HEC]). For example, a gravel carried fluid gelled with 80 lb HEC/1,000 gal has a viscosity of about 400 cp at 170 sec/sup -1/; a viscoelastic surfactant-base system having only one-half the viscosity still flows into cores about four times more efficiently than the HEC-base fluid. The rheology, leakoff, formation damage and mixing properties of a viscoelastic, surfactant-base, gravel-pack carrier fluid are discussed

Theoretical foundations for evidence-based health informatics

DEFF Research Database (Denmark)

Scott, P.; Georgiou, A.; Hypponen, H.

2016-01-01

such as conditional imputation and a ‘‘missing’’- category in multiple regression analyses. Health—exploring complexity: an interdisciplinary systems approach HEC2016 S23 123 Methods A cross sectional survey in a random sample of Danish fishermen was done in 2015 with application of the Nordic questionnaire...... considering relevant confounders were used to look at each single pain site with missing as an additional outcome. In all analyses, sideline occupations, work position, vessel type, education, and duration at sea were considered as further predictors. Results The prevalence of pain was high for all...... excluding all missing’s revealed similar results. Multinomial regression models showed that workload was the only consistent predictor for musculoskeletal pain, in particular regarding upper and lower limb pain. Two additional predictors were found for the nine different pain locations models; sideline...

Smoky River coal flood risk mapping study

Energy Technology Data Exchange (ETDEWEB)

NONE

2004-06-01

The Canada-Alberta Flood Damage Reduction Program (FDRP) is designed to reduce flood damage by identifying areas susceptible to flooding and by encouraging application of suitable land use planning, zoning, and flood preparedness and proofing. The purpose of this study is to define flood risk and floodway limits along the Smoky River near the former Smoky River Coal (SRC) plant. Alberta Energy has been responsible for the site since the mine and plant closed in 2000. The study describes flooding history, available data, features of the river and valley, calculation of flood levels, and floodway determination, and includes flood risk maps. The HEC-RAS program is used for the calculations. The flood risk area was calculated using the 1:100 year return period flood as the hydrological event. 7 refs., 11 figs., 7 tabs., 3 apps.

A laser-based technology for fabricating a soda-lime glass based microfluidic device for circulating tumour cell capture.

Science.gov (United States)

Nieto, Daniel; Couceiro, Ramiro; Aymerich, Maria; Lopez-Lopez, Rafael; Abal, Miguel; Flores-Arias, María Teresa

2015-10-01

We developed a laser-based technique for fabricating microfluidic microchips on soda-lime glass substrates. The proposed methodology combines a laser direct writing, as a manufacturing tool for the fabrication of the microfluidics structures, followed by a post-thermal treatment with a CO2 laser. This treatment will allow reshaping and improving the morphological (roughness) and optical qualities (transparency) of the generated microfluidics structures. The use of lasers commonly implemented for material processing makes this technique highly competitive when compared with other glass microstructuring approaches. The manufactured chips were tested with tumour cells (Hec 1A) after being functionalized with an epithelial cell adhesion molecule (EpCAM) antibody coating. Cells were successfully arrested on the pillars after being flown through the device giving our technology a translational application in the field of cancer research. Copyright © 2015 Elsevier B.V. All rights reserved.

ND:GLASS LASER DESIGN FOR LASER ICF FISSION ENERGY (LIFE)

Energy Technology Data Exchange (ETDEWEB)

Caird, J A; Agrawal, V; Bayramian, A; Beach, R; Britten, J; Chen, D; Cross, R; Ebbers, C; Erlandson, A; Feit, M; Freitas, B; Ghosh, C; Haefner, C; Homoelle, D; Ladran, T; Latkowski, J; Molander, W; Murray, J; Rubenchik, S; Schaffers, K; Siders, C W; Stappaerts, E; Sutton, S; Telford, S; Trenholme, J; Barty, C J

2008-10-28

We have developed preliminary conceptual laser system designs for the Laser ICF (Inertial Confinement Fusion) Fission Energy (LIFE) application. Our approach leverages experience in high-energy Nd:glass laser technology developed for the National Ignition Facility (NIF), along with high-energy-class diode-pumped solid-state laser (HEC-DPSSL) technology developed for the DOE's High Average Power Laser (HAPL) Program and embodied in LLNL's Mercury laser system. We present laser system designs suitable for both indirect-drive, hot spot ignition and indirect-drive, fast ignition targets. Main amplifiers for both systems use laser-diode-pumped Nd:glass slabs oriented at Brewster's angle, as in NIF, but the slabs are much thinner to allow for cooling by high-velocity helium gas as in the Mercury laser system. We also describe a plan to mass-produce pump-diode lasers to bring diode costs down to the order of $0.01 per Watt of peak output power, as needed to make the LIFE application economically attractive.

Calibrating a hydraulic model using water levels derived from time series high-resolution Radarsat-2 synthetic aperture radar images and elevation data

Science.gov (United States)

Trudel, M.; Desrochers, N.; Leconte, R.

2017-12-01

Knowledge of water extent (WE) and level (WL) of rivers is necessary to calibrate and validate hydraulic models and thus to better simulate and forecast floods. Synthetic aperture radar (SAR) has demonstrated its potential for delineating water bodies, as backscattering of water is much lower than that of other natural surfaces. The ability of SAR to obtain information despite cloud cover makes it an interesting tool for temporal monitoring of water bodies. The delineation of WE combined with a high-resolution digital terrain model (DTM) allows extracting WL. However, most research using SAR data to calibrate hydraulic models has been carried out using one or two images. The objectives of this study is to use WL derived from time series high resolution Radarsat-2 SAR images for the calibration of a 1-D hydraulic model (HEC-RAS). Twenty high-resolution (5 m) Radarsat-2 images were acquired over a 40 km reach of the Athabasca River, in northern Alberta, Canada, between 2012 and 2016, covering both low and high flow regimes. A high-resolution (2m) DTM was generated combining information from LIDAR data and bathymetry acquired between 2008 and 2016 by boat surveying. The HEC-RAS model was implemented on the Athabasca River to simulate WL using cross-sections spaced by 100 m. An image histogram thresholding method was applied on each Radarsat-2 image to derive WE. WE were then compared against each cross-section to identify those were the slope of the banks is not too abrupt and therefore amenable to extract WL. 139 observations of WL at different locations along the river reach and with streamflow measurements were used to calibrate the HEC-RAS model. The RMSE between SAR-derived and simulated WL is under 0.35 m. Validation was performed using in situ observations of WL measured in 2008, 2012 and 2016. The RMSE between the simulated water levels calibrated with SAR images and in situ observations is less than 0.20 m. In addition, a critical success index (CSI) was

Palonosetron versus other 5-HT₃ receptor antagonists for prevention of chemotherapy-induced nausea and vomiting in patients with hematologic malignancies treated with emetogenic chemotherapy in a hospital outpatient setting in the United States.

Science.gov (United States)

Craver, Chris; Gayle, Julie; Balu, Sanjeev; Buchner, Deborah

2011-01-01

This study evaluated the rate of uncontrolled chemotherapy-induced nausea and vomiting (CINV) after initiating antiemetic prophylaxis with palonosetron versus other 5-HT₃ receptor antagonists (RAs) in patients diagnosed with hematologic malignancies (lymphoma and leukemia) and receiving highly emetogenic chemotherapy (HEC) or moderately emetogenic chemotherapy (MEC) in a hospital outpatient setting. Patients aged ≥ 18 years and diagnosed with hematologic malignancies initiating HEC or MEC and antiemetic prophylaxis with palonosetron (Group 1) and other 5-HT₃ RAs (Group 2) for the first time in a hospital outpatient setting between 4/1/2007 and 3/31/2009 were identified from the Premier Perspective Database. Within each cycle, CINV events were identified (in the hospital outpatient, inpatient, and emergency room settings) through ICD-9 codes for nausea, vomiting, and/or volume depletion (from each CT administration day 1 until the end of the CT cycle), or use of rescue medications (day 2 until the end of the CT cycle). Negative binomial distribution generalized linear multivariate regression model estimating the CINV event rate on CT, specific CT cycles, and cancer diagnosis (leukemia/lymphoma)-matched groups in the follow-up period (first of 8 cycles or 6 months) was developed. Of 971 identified patients, 211 initiated palonosetron (Group 1). Group 1 patients comprised of more females [50.2 vs. 41.4%; p = 0.0226], Whites [74.4 vs. 70.4%, and Hispanics [7.6 vs. 6.3%; all races p = 0.0105], received more HEC treatments [89.6 vs. 84.2%; all CT types p = 0.0129], and had more lymphoma diagnosed patients [89.6 vs. 76.3%; all cancer types p = 0.0033] at baseline. After controlling for differences in several demographic and clinical variables, the regression model predicted a 20.4% decrease in CINV event rate per CT cycle for Group 1 versus Group 2 patients. Study limitations include potential lack of generalizability, absence of data on certain

Final Scientific/Technical Report for "Enabling Exascale Hardware and Software Design through Scalable System Virtualization"

Energy Technology Data Exchange (ETDEWEB)

Dinda, Peter August [Northwestern Univ., Evanston, IL (United States)

2015-03-17

This report describes the activities, findings, and products of the Northwestern University component of the "Enabling Exascale Hardware and Software Design through Scalable System Virtualization" project. The purpose of this project has been to extend the state of the art of systems software for high-end computing (HEC) platforms, and to use systems software to better enable the evaluation of potential future HEC platforms, for example exascale platforms. Such platforms, and their systems software, have the goal of providing scientific computation at new scales, thus enabling new research in the physical sciences and engineering. Over time, the innovations in systems software for such platforms also become applicable to more widely used computing clusters, data centers, and clouds. This was a five-institution project, centered on the Palacios virtual machine monitor (VMM) systems software, a project begun at Northwestern, and originally developed in a previous collaboration between Northwestern University and the University of New Mexico. In this project, Northwestern (including via our subcontract to the University of Pittsburgh) contributed to the continued development of Palacios, along with other team members. We took the leadership role in (1) continued extension of support for emerging Intel and AMD hardware, (2) integration and performance enhancement of overlay networking, (3) connectivity with architectural simulation, (4) binary translation, and (5) support for modern Non-Uniform Memory Access (NUMA) hosts and guests. We also took a supporting role in support for specialized hardware for I/O virtualization, profiling, configurability, and integration with configuration tools. The efforts we led (1-5) were largely successful and executed as expected, with code and papers resulting from them. The project demonstrated the feasibility of a virtualization layer for HEC computing, similar to such layers for cloud or datacenter computing. For effort (3

78 FR 57001 - Proposed Collection of Information; Comment Request

Science.gov (United States)

2013-09-16

.... Customer Modality Administrative Survey, VA Form 10-0151. b. VA Form Letter 10-491 & HEC Online Survey, 10... processes. The goal of the Customer Modality Survey is to implement a survey process that allows the organization to be proactive in caring for Veterans prior to them receiving services. DATES: Written comments...

The application of enhanced conveyance calculations in flood prediction

Energy Technology Data Exchange (ETDEWEB)

Forbes, G.; Pender, G. [Glasgow Univ. (United Kingdom). Dept. of Civil Engineering

2000-07-01

Over the past twenty years extensive research has been conducted on overbank flow behaviour during river floods. When the main channel flow interacts with flood plain flow, secondary losses other than bed friction act to retard the flow. Traditional one-dimensional modelling tools commonly used in the UK, such as ISIS or HEC-RAS, currently take no account of these secondary losses In an attempt to establish the nature and significance of secondary losses the flood channel facility (FCF) was constructed at HR Wallingford in 1987. As a direct result of the meandering channel series B experiments the James and Wark Method (1992) was developed to predict stage discharge relationships. For a given water level, this method will calculate a value of discharge taking into account the secondary losses. The paper will report on the modification of the method to fit into the river modelling software ISIS. Within the ISIS framework the James and Wark Method is used to calculate conveyance. The aim is to produce a more accurate flood prediction tool than currently exists. The newly developed software has been tested on laboratory data and shown to be highly accurate in both stage discharge and water level prediction. The software has since been applied to natural rivers that have experienced significant flood events. The paper will illustrate the significance of applying flume based conveyance calculation methods at the field scale. (orig.)

Comparison of physical and semi-empirical hydraulic models for flood inundation mapping

Science.gov (United States)

Tavakoly, A. A.; Afshari, S.; Omranian, E.; Feng, D.; Rajib, A.; Snow, A.; Cohen, S.; Merwade, V.; Fekete, B. M.; Sharif, H. O.; Beighley, E.

2016-12-01

Various hydraulic/GIS-based tools can be used for illustrating spatial extent of flooding for first-responders, policy makers and the general public. The objective of this study is to compare four flood inundation modeling tools: HEC-RAS-2D, Gridded Surface Subsurface Hydrologic Analysis (GSSHA), AutoRoute and Height Above the Nearest Drainage (HAND). There is a trade-off among accuracy, workability and computational demand in detailed, physics-based flood inundation models (e.g. HEC-RAS-2D and GSSHA) in contrast with semi-empirical, topography-based, computationally less expensive approaches (e.g. AutoRoute and HAND). The motivation for this study is to evaluate this trade-off and offer guidance to potential large-scale application in an operational prediction system. The models were assessed and contrasted via comparability analysis (e.g. overlapping statistics) by using three case studies in the states of Alabama, Texas, and West Virginia. The sensitivity and accuracy of physical and semi-eimpirical models in producing inundation extent were evaluated for the following attributes: geophysical characteristics (e.g. high topographic variability vs. flat natural terrain, urbanized vs. rural zones, effect of surface roughness paratermer value), influence of hydraulic structures such as dams and levees compared to unobstructed flow condition, accuracy in large vs. small study domain, effect of spatial resolution in topographic data (e.g. 10m National Elevation Dataset vs. 0.3m LiDAR). Preliminary results suggest that semi-empericial models tend to underestimate in a flat, urbanized area with controlled/managed river channel around 40% of the inundation extent compared to the physical models, regardless of topographic resolution. However, in places where there are topographic undulations, semi-empericial models attain relatively higher level of accuracy than they do in flat non-urbanized terrain.

A retrospective streamflow ensemble forecast for an extreme hydrologic event: a case study of Hurricane Irene and on the Hudson River basin

Science.gov (United States)

Saleh, Firas; Ramaswamy, Venkatsundar; Georgas, Nickitas; Blumberg, Alan F.; Pullen, Julie

2016-07-01

This paper investigates the uncertainties in hourly streamflow ensemble forecasts for an extreme hydrological event using a hydrological model forced with short-range ensemble weather prediction models. A state-of-the art, automated, short-term hydrologic prediction framework was implemented using GIS and a regional scale hydrological model (HEC-HMS). The hydrologic framework was applied to the Hudson River basin ( ˜ 36 000 km2) in the United States using gridded precipitation data from the National Centers for Environmental Prediction (NCEP) North American Regional Reanalysis (NARR) and was validated against streamflow observations from the United States Geologic Survey (USGS). Finally, 21 precipitation ensemble members of the latest Global Ensemble Forecast System (GEFS/R) were forced into HEC-HMS to generate a retrospective streamflow ensemble forecast for an extreme hydrological event, Hurricane Irene. The work shows that ensemble stream discharge forecasts provide improved predictions and useful information about associated uncertainties, thus improving the assessment of risks when compared with deterministic forecasts. The uncertainties in weather inputs may result in false warnings and missed river flooding events, reducing the potential to effectively mitigate flood damage. The findings demonstrate how errors in the ensemble median streamflow forecast and time of peak, as well as the ensemble spread (uncertainty) are reduced 48 h pre-event by utilizing the ensemble framework. The methodology and implications of this work benefit efforts of short-term streamflow forecasts at regional scales, notably regarding the peak timing of an extreme hydrologic event when combined with a flood threshold exceedance diagram. Although the modeling framework was implemented on the Hudson River basin, it is flexible and applicable in other parts of the world where atmospheric reanalysis products and streamflow data are available.

Performance Engineering Research Institute SciDAC-2 Enabling Technologies Institute Final Report

Energy Technology Data Exchange (ETDEWEB)

Hall, Mary [University of Utah

2014-09-19

Enhancing the performance of SciDAC applications on petascale systems has high priority within DOE SC. As we look to the future, achieving expected levels of performance on high-end com-puting (HEC) systems is growing ever more challenging due to enormous scale, increasing archi-tectural complexity, and increasing application complexity. To address these challenges, PERI has implemented a unified, tripartite research plan encompassing: (1) performance modeling and prediction; (2) automatic performance tuning; and (3) performance engineering of high profile applications. The PERI performance modeling and prediction activity is developing and refining performance models, significantly reducing the cost of collecting the data upon which the models are based, and increasing model fidelity, speed and generality. Our primary research activity is automatic tuning (autotuning) of scientific software. This activity is spurred by the strong user preference for automatic tools and is based on previous successful activities such as ATLAS, which has automatically tuned components of the LAPACK linear algebra library, and other re-cent work on autotuning domain-specific libraries. Our third major component is application en-gagement, to which we are devoting approximately 30% of our effort to work directly with Sci-DAC-2 applications. This last activity not only helps DOE scientists meet their near-term per-formance goals, but also helps keep PERI research focused on the real challenges facing DOE computational scientists as they enter the Petascale Era.

Personal Exposure to PM2.5 in the Megacity of Mexico: A Multi-Mode Transport Study

Directory of Open Access Journals (Sweden)

Iván Y. Hernández-Paniagua

2018-02-01

Full Text Available Recurrent personal exposure to ambient PM2.5 is associated with adverse human health effects, in particular on the respiratory and cardiovascular systems. Here, we present an assessment of personal exposure and inhalation of PM2.5 for five modes of transport (walking, cycling, public bus (trolleybus and diesel bus, conventional car (CC and hybrid-electric car (HEC and two routes of similar distance, along a major road in the Mexico City metropolitan area (MCMA. Arithmetic average exposure concentrations ranged from 16.5 ± 6.5 µg m−3 for walking to 81.7 ± 9.1 µg m−3 for cycling (henceforth shown as average ±1 SD, with no significant differences with geometric averages. The maximum exposure concentration of 110.9 µg m−3 was observed for the conventional car. The highest exposure concentrations depended on route and the mode of transport, being observed for cycling and walking. The PM2.5 measurements showed large spatial heterogeneity in the exposure levels for walking and cycling, while public buses and private transport showed less spatial heterogeneity. The greatest peaks in PM2.5 coincided with 4-way intersections for all modes of transport, being positively influenced by traffic density. The mass of PM2.5 inhaled depended mostly on the mode of transport, and ranged between 1.0 ± 0.3 and 30.1 ± 14.2 µg km−1 for the HEC and bicycle, respectively. Local area PM2.5 increments identified as ‘residuals’ after subtraction of data recorded at the closest fixed monitoring site from exposure concentrations along the studied road suggested that inhalation for bicycle and diesel buses is strongly influenced by vehicular emissions. Residuals estimated for the trolleybus, CC and HEC confirmed a lower inhalation than for the other modes of transport evaluated due to protection by the cabin.

Responses of the alga Pseudokirchneriella subcapitata to long-term exposure to metal stress

International Nuclear Information System (INIS)

Machado, Manuela D.; Lopes, Ana R.; Soares, Eduardo V.

2015-01-01

Highlights: • Heavy metals provoke a perturbation of the physiological status of Pseudokirchneriella subcapitata. • Cd(II), Cr(VI) and Cu(II), at high concentrations, cause the loss of membrane integrity. • Cd(II), Cr(VI), Cu(II) and Zn(II) inhibit esterase activity in a dose dependent manner. • Heavy metals affect mitochondrial function and photosynthetic activity. • Fluorescent probes are a useful tool in the identification of toxicity targets of the heavy metals. - Abstract: The green alga Pseudokirchneriella subcapitata has been widely used in ecological risk assessment, usually based on the impact of the toxicants in the alga growth. However, the physiological causes that lead algal growth inhibition are not completely understood. This work aimed to evaluate the biochemical and structural modifications in P. subcapitata after exposure, for 72 h, to three nominal concentrations of Cd(II), Cr(VI), Cu(II) and Zn(II), corresponding approximately to 72 h-EC 10 and 72 h-EC 50 values and a high concentration (above 72 h-EC 90 values). The incubation of algal cells with the highest concentration of Cd(II), Cr(VI) or Cu(II) resulted in a loss of membrane integrity of ~16, 38 and 55%, respectively. For all metals tested, an inhibition of esterase activity, in a dose-dependent manner, was observed. Reduction of chlorophyll a content, decrease of maximum quantum yield of photosystem II and modification of mitochondrial membrane potential was also verified. In conclusion, the exposure of P. subcapitata to metals resulted in a perturbation of the cell physiological status. Principal component analysis revealed that the impairment of esterase activity combined with the reduction of chlorophyll a content were related with the inhibition of growth caused by a prolonged exposure to the heavy metals

Validation of different measures of insulin sensitivity of glucose metabolism in dairy cows using the hyperinsulinemic euglycemic clamp test as the gold standard.

Science.gov (United States)

De Koster, J; Hostens, M; Hermans, K; Van den Broeck, W; Opsomer, G

2016-10-01

The aim of the present research was to compare different measures of insulin sensitivity in dairy cows at the end of the dry period. To do so, 10 clinically healthy dairy cows with a varying body condition score were selected. By performing hyperinsulinemic euglycemic clamp (HEC) tests, we previously demonstrated a negative association between the insulin sensitivity and insulin responsiveness of glucose metabolism and the body condition score of these animals. In the same animals, other measures of insulin sensitivity were determined and the correlation with the HEC test, which is considered as the gold standard, was calculated. Measures derived from the intravenous glucose tolerance test (IVGTT) are based on the disappearance of glucose after an intravenous glucose bolus. Glucose concentrations during the IVGTT were used to calculate the area under the curve of glucose and the clearance rate of glucose. In addition, glucose and insulin data from the IVGTT were fitted in the minimal model to derive the insulin sensitivity parameter, Si. Based on blood samples taken before the start of the IVGTT, basal concentrations of glucose, insulin, NEFA, and β-hydroxybutyrate were determined and used to calculate surrogate indices for insulin sensitivity, such as the homeostasis model of insulin resistance, the quantitative insulin sensitivity check index, the revised quantitative insulin sensitivity check index and the revised quantitative insulin sensitivity check index including β-hydroxybutyrate. Correlation analysis revealed no association between the results obtained by the HEC test and any of the surrogate indices for insulin sensitivity. For the measures derived from the IVGTT, the area under the curve for the first 60 min of the test and the Si derived from the minimal model demonstrated good correlation with the gold standard. Copyright © 2016 Elsevier Inc. All rights reserved.

Estimation of sensible and latent heat flux from natural sparse vegetation surfaces using surface renewal

Science.gov (United States)

Zapata, N.; Martínez-Cob, A.

2001-12-01

This paper reports a study undertaken to evaluate the feasibility of the surface renewal method to accurately estimate long-term evaporation from the playa and margins of an endorreic salty lagoon (Gallocanta lagoon, Spain) under semiarid conditions. High-frequency temperature readings were taken for two time lags ( r) and three measurement heights ( z) in order to get surface renewal sensible heat flux ( HSR) values. These values were compared against eddy covariance sensible heat flux ( HEC) values for a calibration period (25-30 July 2000). Error analysis statistics (index of agreement, IA; root mean square error, RMSE; and systematic mean square error, MSEs) showed that the agreement between HSR and HEC improved as measurement height decreased and time lag increased. Calibration factors α were obtained for all analyzed cases. The best results were obtained for the z=0.9 m ( r=0.75 s) case for which α=1.0 was observed. In this case, uncertainty was about 10% in terms of relative error ( RE). Latent heat flux values were obtained by solving the energy balance equation for both the surface renewal ( LESR) and the eddy covariance ( LEEC) methods, using HSR and HEC, respectively, and measurements of net radiation and soil heat flux. For the calibration period, error analysis statistics for LESR were quite similar to those for HSR, although errors were mostly at random. LESR uncertainty was less than 9%. Calibration factors were applied for a validation data subset (30 July-4 August 2000) for which meteorological conditions were somewhat different (higher temperatures and wind speed and lower solar and net radiation). Error analysis statistics for both HSR and LESR were quite good for all cases showing the goodness of the calibration factors. Nevertheless, the results obtained for the z=0.9 m ( r=0.75 s) case were still the best ones.

Pier and contraction scour prediction in cohesive soils at selected bridges in Illinois

Science.gov (United States)

Straub, Timothy D.; Over, Thomas M.

2010-01-01

This report presents the results of testing the Scour Rate In Cohesive Soils-Erosion Function Apparatus (SRICOS-EFA) method for estimating scour depth of cohesive soils at 15 bridges in Illinois. The SRICOS-EFA method for complex pier and contraction scour in cohesive soils has two primary components. The first component includes the calculation of the maximum contraction and pier scour (Zmax). The second component is an integrated approach that considers a time factor, soil properties, and continued interaction between the contraction and pier scour (SRICOS runs). The SRICOS-EFA results were compared to scour prediction results for non-cohesive soils based on Hydraulic Engineering Circular No. 18 (HEC-18). On average, the HEC-18 method predicted higher scour depths than the SRICOS-EFA method. A reduction factor was determined for each HEC-18 result to make it match the maximum of three types of SRICOS run results. The unconfined compressive strength (Qu) for the soil was then matched with the reduction factor and the results were ranked in order of increasing Qu. Reduction factors were then grouped by Qu and applied to each bridge site and soil. These results, and comparison with the SRICOS Zmax calculation, show that less than half of the reduction-factor method values were the lowest estimate of scour; whereas, the Zmax method values were the lowest estimate for over half. A tiered approach to predicting pier and contraction scour was developed. There are four levels to this approach numbered in order of complexity, with the fourth level being a full SRICOS-EFA analysis. Levels 1 and 2 involve the reduction factors and Zmax calculation, and can be completed without EFA data. Level 3 requires some surrogate EFA data. Levels 3 and 4 require streamflow for input into SRICOS. Estimation techniques for both EFA surrogate data and streamflow data were developed.

Emotion recognition in early Parkinson's disease patients undergoing deep brain stimulation or dopaminergic therapy: a comparison to healthy participants

Directory of Open Access Journals (Sweden)

Lindsey G. McIntosh

2015-01-01

Full Text Available Parkinson’s disease (PD is traditionally regarded as a neurodegenerative movement disorder, however, nigrostriatal dopaminergic degeneration is also thought to disrupt non-motor loops connecting basal ganglia to areas in frontal cortex involved in cognition and emotion processing. PD patients are impaired on tests of emotion recognition, but it is difficult to disentangle this deficit from the more general cognitive dysfunction that frequently accompanies disease progression. Testing for emotion recognition deficits early in the disease course, prior to cognitive decline, better assesses the sensitivity of these non-motor corticobasal ganglia-thalamocortical loops involved in emotion processing to early degenerative change in basal ganglia circuits. In addition, contrasting this with a group of healthy aging individuals demonstrates changes in emotion processing specific to the degeneration of basal ganglia circuitry in PD. Early PD patients (EPD were recruited from a randomized clinical trial testing the safety and tolerability of deep brain stimulation of the subthalamic nucleus (STN-DBS in early-staged PD. EPD patients were previously randomized to receive optimal drug therapy only (ODT, or drug therapy plus STN-DBS (ODT+DBS. Matched healthy elderly controls (HEC and young controls (HYC also participated in this study. Participants completed two control tasks and three emotion recognition tests that varied in stimulus domain. EPD patients were impaired on all emotion recognition tasks compared to HEC. Neither therapy type (ODT or ODT+DBS nor therapy state (ON/OFF altered emotion recognition performance in this study. Finally, HEC were impaired on vocal emotion recognition relative to HYC, suggesting a decline related to healthy aging. This study supports the existence of impaired emotion recognition early in the PD course, implicating an early disruption of fronto-striatal loops mediating emotional function.

HMGB1 is negatively correlated with the development of endometrial carcinoma and prevents cancer cell invasion and metastasis by inhibiting the process of epithelial-to-mesenchymal transition

Directory of Open Access Journals (Sweden)

Luan XR

2017-03-01

Full Text Available Xiaorong Luan,1,2 Chunjing Ma,2 Ping Wang,2 Fenglan Lou1 1Nursing College, Shandong University, 2Qilu Hospital of Shandong University, Jinan, People’s Republic of China Abstract: High-mobility group box protein 1 (HMGB1, a nuclear protein that plays a significant role in DNA architecture and transcription, was correlated with the progression of some types of cancer. However, the role of HMGB1 in endometrial cancer cell invasion and metastasis remains unexplored. HMGB1 expression was initially assessed by immunohistochemistry and reverse transcription-quantitative polymerase chain reaction (RT-qPCR in normal endometrial tissue and endometrial carcinoma tissue. High expressions of HMGB1 protein were detected in normal endometrial tissues; however, in endometrial cancer tissues, the expressions of HMGB1 were found to be very weak. Furthermore, HMGB1 expressions were negatively correlated with advanced stage and lymph node metastasis in endometrial cancer. Then by RT-qPCR, Western blot and immunocytochemistry, HMGB1 was also detected in primary cultured endometrial cells and four kinds of endometrial cancer cell lines (Ishikawa, HEC-1A, HEC-1B and KLE. We found that the expression of HMGB1 was much higher in normal endometrial cells than in endometrial cancer cells, and reduced expression levels of HMGB1 were observed especially in the highly metastatic cell lines. Using lentivirus transfection, HMGB1 small hairpin RNA was constructed, and this infected the lowly invasive endometrial cancer cell lines, Ishikawa and HEC-1B. HMGB1 knockdown significantly enhanced the proliferation, invasion and metastasis of endometrial cancer cells and induced the process of epithelial-to-mesenchymal transition. These results can contribute to the development of a new potential therapeutic target for endometrial cancer. Keywords: HMGB1, endometrial cancer, invasion, metastasis, epithelial-to-mesenchymal transition

Visit to the TRIUMF Assembly Site in March 2000

CERN Multimedia

Laskus, H.

2000-01-01

Photo 01 : PAD/EST electrode production Photo 02 : Steel rule die used for cutting Carbon loaded kapton for EST's Photo 03 : Steel rule for cutting PAD/EST electrodes Photo 04 : Clean room for module assembly Photo 05 : Long term HV test of a HEC front module Photo 06 : Container for shipment of modules to CERN

Browse Title Index

African Journals Online (AJOL)

Items 401 - 450 of 913 ... Vol 8, No 2 (2016): Special Issue, Hydro- chemical study of agricultural ... Vol 10, No 1 (2018), Hydrographic network extraction and ... Vol 9, No 2 (2017), Hydrological modeling in semi-arid region using HEC-HMS model. case study in ... Identification of the main processes in new towns Development ...

Radiation crosslinking of methylcellulose and hydroxyethylcellulose in concentrated aqueous solutions

International Nuclear Information System (INIS)

Wach, Radoslaw A.; Mitomo, Hiroshi; Nagasawa, Naotsugu; Yoshii, Fumio

2003-01-01

The effects of ionizing radiation on aqueous solutions of cellulose ethers, methylcellulose (MC) and hydroxyethylcellulose (HEC) were investigated. The well-established knowledge states that cellulose and its derivatives belong to degrading type of polymers. However, in our study intermolecular crosslinking initiated by gamma rays or electron beam leaded to the formation of insoluble gel. This is an opposite effect of irradiation to the degradation. Paste-like form of the initial specimen, i.e. concentration 20-30%, when water plasticizes the bulk of polymer; and a high dose rate were favorable for hydrogel formation. Gel fraction up to 60% and 70% was obtained from solutions of HEC and MC, respectively. Produced hydrogels swell markedly in aqueous media by imbibing and holding the solvent. Radiation parameters of irradiation, such as yields of degradation and crosslinking and the gelation dose, were evaluated by sol-gel analysis on the basis of Charlesby-Rosiak equation. Despite of the crosslinked structure, obtained hydrogels can be included into the group of biodegradable materials. They undergo decomposition by the action of cellulase enzyme or microorganisms from compost

Evaluation of protease resistance and toxicity of amyloid-like food fibrils from whey, soy, kidney bean, and egg white.

Science.gov (United States)

Lassé, Moritz; Ulluwishewa, Dulantha; Healy, Jackie; Thompson, Dion; Miller, Antonia; Roy, Nicole; Chitcholtan, Kenny; Gerrard, Juliet A

2016-02-01

The structural properties of amyloid fibrils combined with their highly functional surface chemistry make them an attractive new food ingredient, for example as highly effective gelling agents. However, the toxic role of amyloid fibrils in disease may cause some concern about their food safety because it has not been established unequivocally if consumption of food fibrils poses a health risk to consumers. Here we present a study of amyloid-like fibrils from whey, kidney bean, soy bean, and egg white to partially address this concern. Fibrils showed varied resistance to proteolytic digestion in vitro by either Proteinase K, pepsin or pancreatin. The toxicity of mature fibrils was measured in vitro and compared to native protein, early-stage-fibrillar protein, and sonicated fibrils in two immortalised human cancer cell lines, Caco-2 and Hec-1a. There was no reduction in the viability of either Caco-2 or Hec-1a cells after treatment with a fibril concentration of up to 0.25 mg/mL. Copyright © 2015 Elsevier Ltd. All rights reserved.

Assessment of climate change impact on river flow regimes in The Red River Delta, Vietnam – A case study of the Nhue-Day River Basin

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Phan Cao Duong

2016-09-01

Full Text Available Global warming has caused dramatic changes in regional climate variability, particularly regarding fluctuations in temperature and rainfall. Thus, it is predicted that river flow regimes will be altered accordingly. The purpose of this paper is to present the results of modeling such changes by simulating discharge using the HEC-HMS model. The precipitation was projected using super-high resolution multiple climate models (20 km resolution with newly updated emission scenarios as the input for the HEC-HMS model for flow analysis at the Red River Basin in the northern area of Vietnam. The findings showed that climate change impact on the river flow regimes tend towards a decrease in the dry season and a longer duration of flood flow. A slight runoff reduction is simulated for November while a considerable runoff increase is modeled for July and August amounting to 30% and 25%, respectively. The discharge scenarios serve as a basis for water managers to develop suitable adaptation methods and responses on the river basin scale.

Pengaruh Land Subsidence terhadap Genangan Banjir dan Rob di Semarang Timur

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ratih Pujiastuti

2016-06-01

Full Text Available Inundation of flood and rob (flood due to high tides in Semarang City is increase wtithin area and depth. It be more seroius condition because of land subsisdence that happened in coastal area of Semarang City. This research is foccused on prediction and mapping of inundation flood and rob due to land subsidence effect in East Semarang, especially Tenggang Watershed and Sringin Watershed. On this research, data analysis including analysis of land subsidence, analysis of hydrological data, analysis of flood discharge with HEC-HMS, hydraulics analysis with HEC-RAS and then mapping the results of the flood inundation with Arc GIS. The inundation will be create with overlay the DEM of flood water level and DEM of topographic. According to the results of analysis is known that minimum land subsidence is 0 cm/year that happened in south area of Semarang and more higher ini north area with maximum land subsidence is 5.58 cm/year. On periode   2014-2031, the contribute of land subsidence to increase the inundation of flood and rob is 1.39%/year.

Hydro-Economic based Model of Damage and Loss Analysis of Winongo River Flood

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Muhammad Rifki Hardika

2017-09-01

Full Text Available Winongo River experienced considerably high flow that caused overflows along the downstream part of the river and some inundation at the surrounding area. The inundation has reached up to 1 m spread over the Tegalrejo Sub-district of Yogyakarta City and swept two houses. This paper analyses the damage and loss due to the flood by taking into account the hydraulics phenomena and the economic impact at the inundation area. A hydraulics model has been developed to study the flow characteristics during the flood of Winongo River, especially in the river reach in Tegalrejo Sub-district. The hazard-induced damages in the flooded area were identified and the economic impacts were studied. Several related software have been utilized to analyse the damage and loss of the disaster, including the HEC-RAS 5.0, ArcGIS, HEC-GeoRAS and InaSAFE. Through the integration of the characteristics of both flood phenomena and the economic factor, the damage and loss were then analysed and the Average Annual Damage (AAD of approximately IDR 88,750,000,000 was obtained.

End-cap calorimeter performance and identification of the t-channel single top quark process with the ATLAS detector

CERN Document Server

Cojocaru, Claudiu D

2008-01-01

The LHC collider will provide proton-proton collisions with 14 TeV centre of mass energy and an expected peak luminosity of 10 34 cm -2 s -1 . ATLAS is one of the multipurpose detectors that will be used for particles detection and measurement of properties. The first part of this thesis focuses on the study of the response of the ATLAS electromagnetic and hadronic end-cap calorimeters (EMEC and HEC, respectively) in a beam test performed in the summer of 2002. For the EMEC, the dependence of the measured signal versus the beam energy was found to be linear and an electromagnetic conversion constant [Special characters omitted.] = (0.446 ± 0.009) MeV/nA was calculated. The energy resolution for the EMEC was [Special characters omitted.] = [Special characters omitted.] ⊕ (0.4 ± 0.1)%, while for the HEC it was [Special characters omitted.] = [Special characters omitted.] ⊕ (3.0 ± 0.2)%, where the reconstructed energy, E reco , is in GeV. These results feed back into the tuning of the calorimeter Monte Ca...

Study on Flood Management Plan in Surabaya City

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Anton Dharma Pusaka Mas

2015-05-01

Full Text Available The area alongside the Gunung Sari Channel has an important meaning to the development of Surabaya City. The rising development in this area which causes the increase of flood events induces negative impacts on the growth of Surabaya City. The flood management plan in Gunung Sari Channel has been conducted by Brantas Project since 1988. This planning was reviewed in 1993 and 1999. This research was conducted to analyze the performance of flood management plan by Brantas Project. It was constructively done by HEC-FDA Software which can develop risk analysis by including economic consideration. Hydro-Economy approach integrated with the HEC-FDA analysis can yield the indicator of flood management plan performance in the form of total cost and risk cost (Expected Annual Damage/EAD. The best total cost yielded from the analysis was Rp. 893,692,230, while the risk cost was Rp. 384,238,410/year. It is expected that this research result can used for achieving best performance for floods management in Gunung Sari Channel.

Structural and ionic conductivity studies on proton conducting solid biopolymer electrolyte based on 2hydroxyethyl cellulose incorporated DTAB

Science.gov (United States)

Ahmad, N. H.; Bakar, N. Y.; Isa, M. I. N.

2017-09-01

Solid biopolymer electrolytes (SBEs) based on 2hydroxyethyl cellulose (2HEC) complexes with dodecyltrimethyl ammonium bromide (DTAB) salt in various composition (wt. %) were successfully prepared by using solution casting technique. The ion - polymer interaction and structural studies have been reported by Fourier transform infrared spectroscopy (FTIR) supported with X - ray diffraction (XRD) and Electrical impedance spectroscopy (EIS). FTIR spectral shows interaction of 2HEC with DTAB happen at peak 2914cm-1, 2848cm-1, 2353cm-1, 2328cm-1, 1720cm-1, 1437cm-1, 1344cm-1, 1198cm-1 1095cm-1 1051cm-1, 912cm-1 and 872cm-1. The interaction of complexes leads to an increase in number of ion jump into neighboring vacant sites until it reaches the highest conductivity at room temperature which is 2.80 x 10-5 Scm-1 for sample containing 9wt. % of DTAB. The temperature dependence of the SBEs system exhibits Arrhenius behavior and the XRD spectral analysis shows the higher salt loading the crystallinity of the SBEs which also increased.

Effects of oxytetracycline and amoxicillin on development and biomarkers activities of zebrafish (Danio rerio).

Science.gov (United States)

Oliveira, Rhaul; McDonough, Sakchai; Ladewig, Jessica C L; Soares, Amadeu M V M; Nogueira, António J A; Domingues, Inês

2013-11-01

Antibiotics have been widely used in human and veterinary medicine to treat or prevent diseases. Residues of antibiotics have been found in aquatic environments, but their effects on fish have been not properly investigated. This work aimed to assess the sub-lethal effects of oxytetracycline and amoxicillin on zebrafish development and biomarkers. Embryos and adults were exposed during 96 h to amoxicillin and oxytetracycline following OECD guidelines. Tissues of adults and pools of embryos were used for catalase, glutathione-S-transferases and lactate dehydrogenase determinations. Amoxicillin caused premature hatching (48 h-EC50=132.4 mg/l) whereas oxytetracycline cause delayed hatching of embryos (72 h-EC50=127.6 mg/l). Moreover, both antibiotics inhibited catalase and induced glutathione-S-transferases in zebrafish adults. However, only oxytetracycline induced lactate dehydrogenase. Short-term effects of antibiotics were observed at high doses (mg/l) indicating that physiological impairment in fish populations is unlike to occur. However, effects of chronic exposures to low doses of ABs must be investigated. Copyright © 2013 Elsevier B.V. All rights reserved.

Twice-daily application of HIV microbicides alter the vaginal microbiota.

Science.gov (United States)

Ravel, Jacques; Gajer, Pawel; Fu, Li; Mauck, Christine K; Koenig, Sara S K; Sakamoto, Joyce; Motsinger-Reif, Alison A; Doncel, Gustavo F; Zeichner, Steven L

2012-12-18

Vaginal HIV microbicides offer great promise in preventing HIV transmission, but failures of phase 3 clinical trials, in which microbicide-treated subjects had an increased risk of HIV transmission, raised concerns about endpoints used to evaluate microbicide safety. A possible explanation for the increased transmission risk is that the agents shifted the vaginal bacterial community, resulting in loss of natural protection and enhanced HIV transmission susceptibility. We characterized vaginal microbiota, using pyrosequencing of bar-coded 16S rRNA gene fragments, in samples from 35 healthy, sexually abstinent female volunteer subjects (ages 18 to 50 years) with regular menses in a repeat phase 1 study of twice-daily application over 13.5 days of 1 of 3 gel products: a hydroxyethylcellulose (HEC)-based "universal" placebo (10 subjects), 6% cellulose sulfate (CS; 13 subjects), and 4% nonoxynol-9 (N-9; 12 subjects). We used mixed effects models inferred using Bayesian Markov chain Monte Carlo methods, which showed that treatment with active agents shifted the microbiota toward a community type lacking significant numbers of Lactobacillus spp. and dominated by strict anaerobes. This state of the vaginal microbiota was associated with a low or intermediate Nugent score and was not identical to bacterial vaginosis, an HIV transmission risk factor. The placebo arm contained a higher proportion of communities dominated by Lactobacillus spp., particularly L. crispatus, throughout treatment. The data suggest that molecular evaluation of microbicide effects on vaginal microbiota may be a critical endpoint that should be incorporated in early clinical assessment of microbicide candidates. Despite large prevention efforts, HIV transmission and acquisition rates remain unacceptably high. In developing countries, transmission mainly occurs through heterosexual intercourse, where women are significantly more vulnerable to infection than men. Vaginal microbicides are considered to

A divergent calponin homology (NN–CH) domain defines a novel family

DEFF Research Database (Denmark)

Schou, Kenneth Bødtker; Andersen, Jens S.; Pedersen, Lotte Bang

2014-01-01

and NUF2 share evolutionary ancestry with a novel protein family in mammals comprising, besides NDC80/HEC1 and NUF2, three Intraflagellar Transport (IFT) complex B subunits (IFT81, IFT57, CLUAP1) as well as six proteins with poorly defined function (FAM98A-C, CCDC22, CCDC93 and C14orf166). We show...

Field efficacy of inorganic carrier based formulations of Serratia ...

African Journals Online (AJOL)

On the basis of the result of this experiment, it can be recommended that vermiculite (80 g/100 g of product) based formulation of S. entomophila AB2 applied at 3.6 qt hec-1 in sesame could be an effective measure of lepidopteron pest control as well as biofertilizer for qualitative and quantitative increase of sesame.

Partnership For Edge Physics Simulation

Energy Technology Data Exchange (ETDEWEB)

PARASHAR, MANISH

2018-04-02

In this effort, we will extend our prior work as part of CPES (i.e., DART and DataSpaces) to support in-situ tight coupling between application codes that exploits data locality and core-level parallelism to maximize on-chip data exchange and reuse. This will be accomplished by mapping coupled simulations so that the data exchanges are more localized within the nodes. Coupled simulation workflows can more effectively utilize the resources available on emerging HEC platforms if they can be mapped and executed to exploit data locality as well as the communication patterns between application components. Scheduling and running such workflows requires an extended framework that should (1) provide a unified hybrid abstraction to enable coordination and data sharing across computation tasks that run on the heterogeneous multi-core-based systems, and (2) develop a data-locality based dynamic tasks scheduling approach to increase on-chip or intra-node data exchanges and in-situ execution. This effort will extend our prior work as part of CPES (i.e., DART and DataSpaces), which provided a simple virtual shared-space abstraction hosted at the staging nodes, to support application coordination, data sharing and active data processing services. Moreover, it will transparently manage the low-level operations associated with the inter-application data exchange, such as data redistributions, and will enable running coupled simulation workflow on multi-cores computing platforms.

AKTIVITAS GEL MULUT BERBAHAN AKTIF EKSTRAK DAUN SIRIH HITAM KALIMANTAN SEBAGAI ANTIMIKROBA PENYEBAB RADANG GUSI (Gingivitis DAN GIGI BERLUBANG (Caries

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Fajar Prasetya

2013-12-01

Full Text Available This study aimed to test the activity of active ingredient mouth gel preparation of kalimantan black piper betle leaf extract with the main base of Hydroxy Ethyl Cellulose namely (HEC as a mucoadhesive polymer that is able to increase the attractive forces between the active material with a layer of mucus that will extend the contact time with the active ingredient tissue targets, moreover would be increase the effectiveness of antimicrobial activity causes inflammation of the gums (gingivitis and tooth decay (caries. Activities that have been implemented are mouth gel activity assays with Kalimantan black piper betle leaf extract as in- vitro using the agar diffusion method pitting. In testing with active oral gel preparation of black piper betle leaf extract with the main base of Hydroxy Ethyl Cellulose namely (HEC as in vitro, it can be seen that the sample may provide the inhibitory effect of the fungus Candida albicans and the bacterium Streptococcus mutans in the presence of a clear zone indicated on the medium. Furthermore, at this stage of the dilution of the gel in twice causing decline in the effectiveness of the inhibition of both the fungus Candida albicans and the bacterium Streptococcus mutans. The results of in- vitro testing without dilution is 19.8 mm in bacteria Streptococcus mutans and 34.4 mm in the fungus Candida albicans. Keywords: antimicrobial, oral gel, black piper betle, gingivitis , cavities   ABSTRAK Penelitian ini bertujuan untuk menguji aktivitas sediaan gel mulut berbahan aktif ekstrak daun sirih hitam Kalimantan dengan basis utama yakni Hydroxy Ethyl Cellulose (HEC sebagai mucoadhesive polymer yang mampu meningkatkan gaya tarik menarik antara bahan aktif dengan lapisan mukus sehingga akan memperpanjang waktu kontak bahan aktif dengan jaringan target, selanjutnya akan meningkatkan efektivitas aktivitas antimikroba penyebab radang gusi (gingivitis dan gigi berlubang (caries. Kegiatan yang telah dilaksanakan adalah

HEC-RAS 2.2 for backwater and scour analysis - phase one

Science.gov (United States)

2000-09-01

The Kansas Department of Transportation (KDOT) and most bridge consultants in Kansas have been using the DOS-WSPRO program and the KDOT scour spreadsheets to perform bridge hydraulics and scour analysis for the past several years. Unfortunately, DOS-...

A Flash Flood Study on the Small Montaneous River Catchments in Western Romania

Science.gov (United States)

Győri, Maria-Mihaela; Haidu, Ionel; Humbert, Joël

2013-04-01

The present study focuses on flash flood modeling on several mountaneous catchments situated in Western Romania by the use of two methodologies, when rainfall and catchment characteristics are known. Hence, the Soil Conservation Service (SCS) Method and the Rational Method will be employed for the generation of the 1%, 2% and 10% historical flash flood hydrographs on the basis of data spanning from 1989-2009. The SCS Method has been applied on the three gauged catchments in the study area: Petris, Troas and Monorostia making use of the existing interconnection between GIS and the rainfall-runoff models. The DEM, soil data and land use preprocessing in GIS allowed a determination of the hydrologic parameters needed for the rainfall-runoff model, with special emphasis on determining the time of concentration, Lag time and the weighted Curve Number according to Antecedent Moisture Conditions II, adapted for the Romanian territory. HEC-HMS rainfall-runoff model (Hydrologic Engineering Center- Hydrologic Modeling System) facilitates the historical 1%, 2% and 10% flash flood hydrograph generation for the three afore mentioned watersheds. The model is calibrated against measured streamflow data from the three existing gauging stations. The results show a good match between the resulted hydrographs and the observed hydrographs under the form of the Peak Weighted Error RMS values. The hydrographs generated by surface runoff on the ungauged catchments in the area is based on an automation of a workflow in GIS, built with ArcGIS Model Builder graphical interface, as a large part of the functions needed were available as ArcGIS tools. The several components of this model calculate: the runoff depth in mm, the runoff coefficient, the travel time and finally the discharge module which is an application of the rational method, allowing the discharge computation for every cell within the catchment. The result consists of discharges for each isochrones that will be subsequently

Comparative evaluation of 1D and quasi-2D hydraulic models based on benchmark and real-world applications for uncertainty assessment in flood mapping

Science.gov (United States)

Dimitriadis, Panayiotis; Tegos, Aristoteles; Oikonomou, Athanasios; Pagana, Vassiliki; Koukouvinos, Antonios; Mamassis, Nikos; Koutsoyiannis, Demetris; Efstratiadis, Andreas

2016-03-01

One-dimensional and quasi-two-dimensional hydraulic freeware models (HEC-RAS, LISFLOOD-FP and FLO-2d) are widely used for flood inundation mapping. These models are tested on a benchmark test with a mixed rectangular-triangular channel cross section. Using a Monte-Carlo approach, we employ extended sensitivity analysis by simultaneously varying the input discharge, longitudinal and lateral gradients and roughness coefficients, as well as the grid cell size. Based on statistical analysis of three output variables of interest, i.e. water depths at the inflow and outflow locations and total flood volume, we investigate the uncertainty enclosed in different model configurations and flow conditions, without the influence of errors and other assumptions on topography, channel geometry and boundary conditions. Moreover, we estimate the uncertainty associated to each input variable and we compare it to the overall one. The outcomes of the benchmark analysis are further highlighted by applying the three models to real-world flood propagation problems, in the context of two challenging case studies in Greece.

A preliminary comparison of hydrodynamic approaches for flood inundation modeling of urban areas in Jakarta Ciliwung river basin

Science.gov (United States)

Rojali, Aditia; Budiaji, Abdul Somat; Pribadi, Yudhistira Satya; Fatria, Dita; Hadi, Tri Wahyu

2017-07-01

This paper addresses on the numerical modeling approaches for flood inundation in urban areas. Decisive strategy to choose between 1D, 2D or even a hybrid 1D-2D model is more than important to optimize flood inundation analyses. To find cost effective yet robust and accurate model has been our priority and motivation in the absence of available High Performance Computing facilities. The application of 1D, 1D/2D and full 2D modeling approach to river flood study in Jakarta Ciliwung river basin, and a comparison of approaches benchmarked for the inundation study are presented. This study demonstrate the successful use of 1D/2D and 2D system to model Jakarta Ciliwung river basin in terms of inundation results and computational aspect. The findings of the study provide an interesting comparison between modeling approaches, HEC-RAS 1D, 1D-2D, 2D, and ANUGA when benchmarked to the Manggarai water level measurement.

Occurrence of Putative Virulence Genes in Arcobacter Species Isolated from Humans and Animals

Science.gov (United States)

Douidah, Laid; de Zutter, Lieven; Baré, Julie; De Vos, Paul; Vandamme, Peter; Vandenberg, Olivier; Van den Abeele, Anne-Marie

2012-01-01

Interest in arcobacters in veterinary and human public health has increased since the first report of the isolation of arcobacters from food of animal origin. Since then, studies worldwide have reported the occurrence of arcobacters on food and in food production animals and have highlighted possible transmission, especially of Arcobacter butzleri, to the human population. In humans, arcobacters are associated with enteritis and septicemia. To assess their clinical relevance for humans and animals, evaluation of potential virulence factors is required. However, up to now, little has been known about the mechanisms of pathogenicity. Because of their close phylogenetic affiliation to the food-borne pathogen Campylobacter and their similar clinical manifestations, the presence of nine putative Campylobacter virulence genes (cadF, ciaB, cj1349, hecA, hecB, irgA, mviN, pldA, and tlyA) previously identified in the recent Arcobacter butzleri ATCC 49616 genome sequence was determined in a large set of human and animal Arcobacter butzleri, Arcobacter cryaerophilus, and Arcobacter skirrowii strains after the development of rapid and accurate PCR assays and confirmed by sequencing and dot blot hybridization. PMID:22170914

Factors Influencing the Spatial Difference in Household Energy Consumption in China

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Yongxia Ding

2016-12-01

Full Text Available What factors determine the spatial heterogeneity of household energy consumption (HEC in China? Can the impacts of these factors be quantified? What are the trends and characteristics of the spatial differences? To date, these issues are still unclear. Based on the STIRPAT model and panel dataset for 30 provinces in China over the period 1997–2013, this paper investigated influences of the income per capita, urbanization level and annual average temperature on HEC, and revealed the spatial effects of these influencing factors. The results show that the income level is the main influencing factor, followed by the annual average temperature. There exists a diminishing marginal contribution with increasing income. The influence of urbanization level varies according to income level. In addition, from the eastern region to western region of China, variances largely depend upon economic level at the provincial level. From the northern region to southern region, change is mainly caused by temperature. The urbanization level has more significant impact on the structure and efficiency of household energy consumption than on its quantity. These results could provide reference for policy making and energy planning.

Hydrodynamic Modeling on Suciu River (Maramures County

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Năsui Daniel

2016-06-01

Full Text Available The GIS database containing the topographic and land use information was made in 2012, followed by field measurements surveys in 2013 and 2014. A number of 11 cross-sections were topographically apprised in the valley along the 11 km river reach. The geometric data requirements for the modeling software were prepared in ESRI’s ArcGIS™ 9.2 software using the HEC-GeoRAS extension. The steady flow data was edited in the HEC-RAS one-dimensional flow modeling software. Four scenarios were used for the river discharge, from normal to overflow. The results come in different forms, from tabular output, to stage hydrograph, to velocity distribution or 3D diagrams, all of which give a clear vision on the overflow high risk areas. The results were exported back to the GIS extension for additional spatial operations. Flow velocity maps were generated for each discharge scenario. Although the scenarios included very high discharge values, the flood impact on people assets is minimal. The reasons for this are the high slope of the riverbed and the proper placement in the floodplain, due mainly to the flood management works that took place after the 1970 flood.

Fisetin induces G2/M phase cell cycle arrest by inactivating cdc25C-cdc2 via ATM-Chk1/2 activation in human endometrial cancer cells

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Zhan-Ying Wang

2015-06-01

Full Text Available Endometrial cancer is one of the most prevalent gynaecological malignancies where, currently available therapeutic options remain limited. Recently phytochemicals are exploited for their efficiency in cancer therapy. The present study investigates the anti-proliferative effect of fisetin, a flavonoid on human endometrial cancer cells (KLE and Hec1 A. Fisetin (20-100 µM effectively reduced the viability of Hec1 A and KLE cells and potentially altered the cell population at G2/M stage. Expression levels of the cell cycle proteins (cyclin B1, p-Cdc2, p-Cdc25C, p-Chk1, Chk2, p-ATM, cyclin B1, H2AX, p21 and p27 were analyzed. Fisetin suppressed cyclin B1 expression and caused inactiva-tion of Cdc25C and Cdc2 by increasing their phosphorylation levels and further activated ATM, Chk1 and Chk2. Increased levels of p21 and p27 were observed as well. These results suggest that fisetin induced G2/M cell cycle arrest via inactivating Cdc25c and Cdc2 through activation of ATM, Chk1 and Chk2.

Analysis of flood vulnerability in urban area; a case study in deli watershed

Science.gov (United States)

Indrawan, I.; Siregar, R. I.

2018-03-01

Based on the National Disaster Management Agency of Indonesia, the distribution of disasters and victims died until the year 2016 is the largest flood disaster. Deli River is a river that has the greatest flood potential through Medan City. In Deli Watershed, flow discharge affected by the discharge from its tributaries, the high rainfall intensity and human activity. We should anticipate reducing and preventing the occurrence of losses due to flood damage. One of the ways to anticipate flood disaster is to predict which part of urban area is would flood. The objective of this study is to analyze the flood inundation areas due to overflow of Deli River through Medan city. Two-dimensional modeling by HEC-RAS 5.0.3 is a widely used hydraulic software tool developed by the U.S Army Corps of Engineers, which combined with the HEC-HMS for hydrological modeling. The result shows flood vulnerability in Medan by a map to present the spot that vulnerable about flood. The flooded area due to the overflowing of Deli River consists of seven sub districts, namely Medan Johor, Medan Selayang, Medan Kota, Medan Petisah, Medan Maimun, Medan Perjuangan and Medan Barat.

Tyrosol and its metabolites as antioxidative and anti-inflammatory molecules in human endothelial cells.

Science.gov (United States)

Muriana, Francisco J G; Montserrat-de la Paz, Sergio; Lucas, Ricardo; Bermudez, Beatriz; Jaramillo, Sara; Morales, Juan C; Abia, Rocio; Lopez, Sergio

2017-08-01

Tyrosol (Tyr) is a phenolic compound found in virgin olive oil. After ingestion, Tyr undergoes extensive first pass intestinal/hepatic metabolism. However, knowledge about the biological effects of Tyr metabolites is scarce. We chemically synthesized Tyr glucuronate (Tyr-GLU) and sulphate (Tyr-SUL) metabolites and explored their properties against oxidative stress and inflammation in TNF-α-treated human umbilical vein endothelial cells (hECs). Tyr and Tyr-SUL prevented the rise of reactive oxygen species, the depletion of glutathione, and the down-regulation of glutathione peroxidase 1, glutamate-cysteine ligase catalytic subunit, and heme oxygenase-1 genes. Tyr-SUL and to a lower extent Tyr and Tyr-GLU prevented the phosphorylation of NF-κB signaling proteins. Tyr-GLU and Tyr-SUL also prevented the over-expression of adhesion molecules at gene, protein, and secretory levels, and the adhesion (Tyr-SUL > Tyr-GLU) of human monocytes to hECs. In vivo, Tyr, and most notably Tyr-SUL in a dose-dependent manner, ameliorated plantar and ear edemas in mice models of acute and chronic inflammation. This study demonstrates the antioxidant and/or anti-inflammatory properties of Tyr metabolites, with Tyr-SUL being the most effective.

USACE Regional Sediment Management and Engineering with Nature 2013 Workshop Summary

Science.gov (United States)

2014-08-01

Tools into HEC-RAS St. Louis Kaskaskia River Navigation Channel Mobile Biodegradable Containment Structures for RSM Honolulu Hawaii RSM – Haleiwa...sediment from USACE to private entities for use. Share successes and lessons learned.  Increase the use of vegetation and other biodegradable ...beaches, and submerged mounds) and construction materials (e.g., reef balls, combination of rock sills and oyster bags , native plants, and

Cytotoxicity and analysis of apoptosis gene expression in colon cancer cell line treated with cell extract of Lactobacillus casei as indigenous probiotic bacterium

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Amir Mirzaie

2017-03-01

Full Text Available Background and aim: Nowadays, the probiotic bacteria such as lactobacilli are known as prevention factor for various disease especially cancer. The aim of this study was to investigate the cytotoxic effect of Lactobacillus casei PTCC 1608 cell extract as probiotic bacteria on colon cancer cell line (HT29 and analysis of Bax and Bcl2 apoptosis gene expression. Methods: In this experimental study, the cell extract of heat killed L. casei was prepared in 0.01, 0.1, 1, 10, 100 and 1000 µg/ml concentration and subsequently, the cytotoxicity of various cell extracts on HT29 and HEC293 cell lines were evaluated in 24 hours using MTT assay. Moreover, the Bax and Bcl2 apoptosis gene expression level in HT29 cell line was analyzed using Real Time PCR. The apoptotic effects of cell extract was determined using Flow-cytometry technique. Finally, the collected data were statistically analyzed using one-way anal­ysis of variance with the SPSS/18 software. Results: The results of MTT test show that cell extracts of L. casei is able to reduce the survival rate of HT29 cell line to 0.95±0.44, 73.45±0.21, 51.49±0.87, 39.5±0.45 and 19.7±0.55. In addition to, the Real Time PCR results indicated the expression level of Bax and Bcl2 was increased and decreased respectively, in HT29 cell line (2.76 ± 0.54 (P<0.05, 0.21 ± 0.43 (P< 0.05 in 24 h. Moreover, the flow cytometry results indicated the 35.62 % apoptosis in HT29 cell line treated with IC50 value. Conclusion: The results show that the cell extract of L. casei PTCC 1608 could induced the apoptosis in HT29 cell line and it had low toxicity on HEC293 cell line. Therefore, it seems that L. casei has potential uses as probiotic for pharmaceutical applications including prevention and treatment of colon cancer.

Hydrologic Simulation in Mediterranean flood prone Watersheds using high-resolution quality data

Science.gov (United States)

Eirini Vozinaki, Anthi; Alexakis, Dimitrios; Pappa, Polixeni; Tsanis, Ioannis

2015-04-01

Flooding is a significant threat causing lots of inconveniencies in several societies, worldwide. The fact that the climatic change is already happening, increases the flooding risk, which is no longer a substantial menace to several societies and their economies. The improvement of spatial-resolution and accuracy of the topography and land use data due to remote sensing techniques could provide integrated flood inundation simulations. In this work hydrological analysis of several historic flood events in Mediterranean flood prone watersheds (island of Crete/Greece) takes place. Satellite images of high resolution are elaborated. A very high resolution (VHR) digital elevation model (DEM) is produced from a GeoEye-1 0.5-m-resolution satellite stereo pair and is used for floodplain management and mapping applications such as watershed delineation and river cross-section extraction. Sophisticated classification algorithms are implemented for improving Land Use/ Land Cover maps accuracy. In addition, soil maps are updated with means of Radar satellite images. The above high-resolution data are innovatively used to simulate and validate several historical flood events in Mediterranean watersheds, which have experienced severe flooding in the past. The hydrologic/hydraulic models used for flood inundation simulation in this work are HEC-HMS and HEC-RAS. The Natural Resource Conservation Service (NRCS) curve number (CN) approach is implemented to account for the effect of LULC and soil on the hydrologic response of the catchment. The use of high resolution data provides detailed validation results and results of high precision, accordingly. Furthermore, the meteorological forecasting data, which are also combined to the simulation model results, manage the development of an integrated flood forecasting and early warning system tool, which is capable of confronting or even preventing this imminent risk. The research reported in this paper was fully supported by the

Novel intravaginal nanomedicine for the targeted delivery of saquinavir to CD4+ immune cells

Directory of Open Access Journals (Sweden)

Yang S

2013-08-01

Full Text Available Sidi Yang,1,2 Yufei Chen,1,2 Kaien Gu,1,2 Alicia Dash,1,2 Casey L Sayre,1 Neal M Davies,1 Emmanuel A Ho1,2 1Faculty of Pharmacy, 2Laboratory for Drug Delivery and Biomaterials, University of Manitoba, Winnipeg, MB, Canada Abstract: The goal of this study was to develop and characterize an intravaginal nanomedicine for the active targeted delivery of saquinavir (SQV to CD4+ immune cells as a potential strategy to prevent or reduce HIV infection. The nanomedicine was formulated into a vaginal gel to provide ease in self-administration and to enhance retention within the vaginal tract. SQV-encapsulated nanoparticles (SQV-NPs were prepared from poly(lactic-co-glycolic acid(PLGA and conjugated to antihuman anti-CD4 antibody. Antibody-conjugated SQV-NPs (Ab-SQV-NPs had an encapsulation efficiency (EE% of 74.4% ± 3.7% and an antibody conjugation efficiency (ACE% of 80.95% ± 1.10%. Over 50% of total loaded SQV was released from NPs over 3 days. NPs were rapidly taken up by Sup-T1 cells, with more than a twofold increase in the intracellular levels of SQV when delivered by Ab-SQV-NPs in comparison to controls 1 hour post-treatment. No cytotoxicity was observed when vaginal epithelial cells were treated for 24 hours with drug-free Ab-NPs (1,000 µg/mL, 1% HEC placebo gel (200 mg/mL, or 1% HEC gel loaded with drug-free Ab-NPs (5 mg NPs/g gel, 200 mg/mL of gel mixture. Overall, we described an intravaginal nanomedicine that is nontoxic and can specifically deliver SQV into CD4+ immune cells. This platform may demonstrate potential utility in its application as postexposure prophylaxis for the treatment or reduction of HIV infection, but further studies are required. Keywords: nanoparticles, saquinavir, antibody conjugation, intravaginal gel, HIV/AIDS, microbicide

Comparison of new generation low-complexity flood inundation mapping tools with a hydrodynamic model

Science.gov (United States)

Afshari, Shahab; Tavakoly, Ahmad A.; Rajib, Mohammad Adnan; Zheng, Xing; Follum, Michael L.; Omranian, Ehsan; Fekete, Balázs M.

2018-01-01

The objective of this study is to compare two new generation low-complexity tools, AutoRoute and Height Above the Nearest Drainage (HAND), with a two-dimensional hydrodynamic model (Hydrologic Engineering Center-River Analysis System, HEC-RAS 2D). The assessment was conducted on two hydrologically different and geographically distant test-cases in the United States, including the 16,900 km2 Cedar River (CR) watershed in Iowa and a 62 km2 domain along the Black Warrior River (BWR) in Alabama. For BWR, twelve different configurations were set up for each of the models, including four different terrain setups (e.g. with and without channel bathymetry and a levee), and three flooding conditions representing moderate to extreme hazards at 10-, 100-, and 500-year return periods. For the CR watershed, models were compared with a simplistic terrain setup (without bathymetry and any form of hydraulic controls) and one flooding condition (100-year return period). Input streamflow forcing data representing these hypothetical events were constructed by applying a new fusion approach on National Water Model outputs. Simulated inundation extent and depth from AutoRoute, HAND, and HEC-RAS 2D were compared with one another and with the corresponding FEMA reference estimates. Irrespective of the configurations, the low-complexity models were able to produce inundation extents similar to HEC-RAS 2D, with AutoRoute showing slightly higher accuracy than the HAND model. Among four terrain setups, the one including both levee and channel bathymetry showed lowest fitness score on the spatial agreement of inundation extent, due to the weak physical representation of low-complexity models compared to a hydrodynamic model. For inundation depth, the low-complexity models showed an overestimating tendency, especially in the deeper segments of the channel. Based on such reasonably good prediction skills, low-complexity flood models can be considered as a suitable alternative for fast

Divergent migration within lake sturgeon (Acipenser fulvescens) populations: Multiple distinct patterns exist across an unrestricted migration corridor.

Science.gov (United States)

Kessel, Steven T; Hondorp, Darryl W; Holbrook, Christopher M; Boase, James C; Chiotti, Justin A; Thomas, Michael V; Wills, Todd C; Roseman, Edward F; Drouin, Richard; Krueger, Charles C

2018-01-01

Population structure, distribution, abundance and dispersal arguably underpin the entire field of animal ecology, with consequences for regional species persistence, and provision of ecosystem services. Divergent migration behaviours among individuals or among populations are an important aspect of the ecology of highly mobile animals, allowing populations to exploit spatially or temporally distributed food and space resources. This study investigated the spatial ecology of lake sturgeon (Acipenser fulvescens) within the barrier free Huron-Erie Corridor (HEC), which connects Lake Huron and Lake Erie of the North American Laurentian Great Lakes. Over 6 years (2011-2016), movements of 268 lake sturgeon in the HEC were continuously monitored across the Great Lakes using acoustic telemetry (10 years battery life acoustic transmitters). Five distinct migration behaviours were identified with hierarchical cluster analysis, based on the phenology and duration of river and lake use. Lake sturgeon in the HEC were found to contain a high level of intraspecific divergent migration, including partial migration with the existence of residents. Specific behaviours included year-round river residency and multiple lake-migrant behaviours that involved movements between lakes and rivers. Over 85% of individuals were assigned to migration behaviours as movements were consistently repeated over the study, which suggested migration behaviours were consistent and persistent in lake sturgeon. Differential use of specific rivers or lakes by acoustic-tagged lake sturgeon further subdivided individuals into 14 "contingents" (spatiotemporally segregated subgroups). Contingents associated with one river (Detroit or St. Clair) were rarely detected in the other river, which confirmed that lake sturgeon in the Detroit and St. Clair represent two semi-independent populations that could require separate management consideration for their conservation. The distribution of migration behaviours

Divergent migration within lake sturgeon (Acipenser fulvescens) populations: Multiple distinct patterns exist across an unrestricted migration corridor

Science.gov (United States)

Kessel, Steven T.; Hondorp, Darryl W.; Holbrook, Christopher; Boase, James C.; Chiotti, Justin A.; Thomas, Michael V.; Wills, Todd C.; Roseman, Edward; Drouin, Richard; Krueger, Charles C.

2018-01-01

Population structure, distribution, abundance, and dispersal arguably underpin the entire field of animal ecology, with consequences for regional species persistence, and provision of ecosystem services. Divergent migration behaviours among individuals or among populations is an important aspect of the ecology of highly-mobile animals, allowing populations to exploit spatially- or temporally-distributed food and space resources.This study investigated the spatial ecology of lake sturgeon (Acipenser fulvescens) within the barrier free Huron-Erie Corridor (HEC), which connects Lake Huron and Lake Erie of the North American Laurentian Great Lakes.Over six years (2011 – 2016), movements of 268 lake sturgeon in the HEC were continuously monitored across the Great Lakes using acoustic telemetry (10 yr battery life acoustic transmitters). Five distinct migration behaviours were identified with hierarchical cluster analysis, based on the phenology and duration of river and lake use.Lake sturgeon in the HEC were found to contain a high level of intraspecific divergent migration, including partial migration with the existence of residents. Specific behaviours included year-round river residency and multiple lake-migrant behaviours that involved movements between lakes and rivers. Over 85% of individuals were assign to migration behaviours as movements were consistently repeated over the study, which suggested migration behaviours were consistent and persistent in lake sturgeon. Differential use of specific rivers or lakes by acoustic-tagged lake sturgeon further subdivided individuals into 14 “contingents” (spatiotemporally segregated subgroups).Contingents associated with one river (Detroit or St. Clair) were rarely detected in the other river, which confirmed that lake sturgeon in the Detroit and St. Clair represent two semi-independent populations that could require separate management consideration for their conservation. The distribution of migration behaviours

Modeling Guru: Knowledge Base for NASA Modelers

Science.gov (United States)

Seablom, M. S.; Wojcik, G. S.; van Aartsen, B. H.

2009-05-01

Modeling Guru is an on-line knowledge-sharing resource for anyone involved with or interested in NASA's scientific models or High End Computing (HEC) systems. Developed and maintained by the NASA's Software Integration and Visualization Office (SIVO) and the NASA Center for Computational Sciences (NCCS), Modeling Guru's combined forums and knowledge base for research and collaboration is becoming a repository for the accumulated expertise of NASA's scientific modeling and HEC communities. All NASA modelers and associates are encouraged to participate and provide knowledge about the models and systems so that other users may benefit from their experience. Modeling Guru is divided into a hierarchy of communities, each with its own set forums and knowledge base documents. Current modeling communities include those for space science, land and atmospheric dynamics, atmospheric chemistry, and oceanography. In addition, there are communities focused on NCCS systems, HEC tools and libraries, and programming and scripting languages. Anyone may view most of the content on Modeling Guru (available at http://modelingguru.nasa.gov/), but you must log in to post messages and subscribe to community postings. The site offers a full range of "Web 2.0" features, including discussion forums, "wiki" document generation, document uploading, RSS feeds, search tools, blogs, email notification, and "breadcrumb" links. A discussion (a.k.a. forum "thread") is used to post comments, solicit feedback, or ask questions. If marked as a question, SIVO will monitor the thread, and normally respond within a day. Discussions can include embedded images, tables, and formatting through the use of the Rich Text Editor. Also, the user can add "Tags" to their thread to facilitate later searches. The "knowledge base" is comprised of documents that are used to capture and share expertise with others. The default "wiki" document lets users edit within the browser so others can easily collaborate on the

United States Navy Nutrition Culture and How Best to Select Food While Underway

Science.gov (United States)

2013-12-13

Brownies Blueberry Crisp Creamed Beef Cheese Burger Braised Beef and Noodles Soup Egg, Hard Chili Conqui Brownies Egg, Scram (in bag) Corn Bread...Beef Cheese Burger Braised Beef and Noodles Soup Egg, Hard Chili Conqui Brownies Egg, Scram (in bag) Corn Bread Cheese Burger English HEC Crab...Sandwich (sloppy) Breakfast Burrito Calico Corn Beans, White in Tomato Sauce Breakfast Rice Cheese Cake Brown Gravy, Instant Dry Cereal (Cheerios

Robust Prediction of Hydraulic Roughness

Science.gov (United States)

2011-03-01

Manning’s n were required as input for further hydraulic analyses with HEC - RAS . HYDROCAL was applied to compare different estimates of resistance... River Restoration Science Synthesis (NRRSS) demonstrated that, in 2007, river and stream restoration projects and funding were at an all time high...behavior makes this parameter very difficult to quan- tify repeatedly and accurately. A fundamental concept of hydraulic theory in the context of river

study and analysis of asa river hypothetical dam break using hec-ras

African Journals Online (AJOL)

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outcome of the analysis showed that in the event of such failure of Asa dam, some areas which include industrial and residential .... Road Bridge (Coca Cola Axis). (iv) Stretch ..... Solutions and Case Studies, WIT Press, Southampton,. Boston ...

study and analysis of asa river hypothetical dam break using hec-ras

African Journals Online (AJOL)

Impounded reservoirs provide beneficial functions such as flood control, recreation, hydropower and water supply but they also carry potential risks. Spontaneous dam break phenomenon can occur and the resultant flooding may cause substantial loss of life and property damage downstream of the dam. A hypothetical dam ...

Autoantibodies Targeting AT1 Receptor from Patients with Acute Coronary Syndrome Upregulate Proinflammatory Cytokines Expression in Endothelial Cells Involving NF-κB Pathway

Directory of Open Access Journals (Sweden)

Weijuan Li

2014-01-01

Full Text Available Our study intended to prove whether agonistic autoantibodies to angiotensin II type 1 receptor (AT1-AAs exist in patients with coronary heart disease (CHD and affect the human endothelial cell (HEC by upregulating proinflammatory cytokines expression involved in NF-κB pathway. Antibodies were determined by chronotropic responses of cultured neonatal rat cardiomyocytes coupled with receptor-specific antagonists (valsartan and AT1-EC2 as described previously. Interleukin-6 (IL-6, vascular cell adhesion molecule-1 (VCAM-1, and monocyte chemotactic protein-1 (MCP-1 expression were improved at both mRNA and protein levels in HEC, while NF-κB in the DNA level was improved detected by electrophoretic mobility shift assays (EMSA. These improvements could be inhibited by specific AT1 receptor blocker valsartan, NF-κB blocker pyrrolidine dithiocarbamate (PDTC, and specific short peptides from the second extracellular loop of AT1 receptor. These results suggested that AT1-AAs, via the AT1 receptor, induce expression of proinflammatory cytokines involved in the activation of NF-κB. AT1-AAs may play a great role in the pathogenesis of the acute coronary syndrome by mediating vascular inflammatory effects involved in the NF-κB pathway.

Carbon coated nano-LiTi2(PO4)3 electrodes for non-aqueous hybrid supercapacitors.

Science.gov (United States)

Aravindan, V; Chuiling, W; Reddy, M V; Rao, G V Subba; Chowdari, B V R; Madhavi, S

2012-04-28

The Pechini type polymerizable complex decomposition method is employed to prepare LiTi(2)(PO(4))(3) at 1000 °C in air. High energy ball milling followed by carbon coating by the glucose-method yielded C-coated nano-LiTi(2)(PO(4))(3) (LTP) with a crystallite size of 80(±5) nm. The phase is characterized by X-ray diffraction, Rietveld refinement, thermogravimetry, SEM, HR-TEM and Raman spectra. Lithium cycling properties of LTP show that 1.75 moles of Li (~121 mA h g(-1) at 15 mA g(-1) current) per formula unit can be reversibly cycled between 2 and 3.4 V vs. Li with 83% capacity retention after 70 cycles. Cyclic voltammograms (CV) reveal the two-phase reaction mechanism during Li insertion/extraction. A hybrid electrochemical supercapacitor (HEC) with LTP as negative electrode and activated carbon (AC) as positive electrode in non-aqueous electrolyte is studied by CV at various scan rates and by galvanostatic cycling at various current rates up to 1000 cycles in the range 0-3 V. Results show that the HEC delivers a maximum energy density of 14 W h kg(-1) and a power density of 180 W kg(-1). This journal is © the Owner Societies 2012

Cytokine-Like Protein 1(Cytl1: A Potential Molecular Mediator in Embryo Implantation.

Directory of Open Access Journals (Sweden)

Zhichao Ai

Full Text Available Cytokine-like protein 1 (Cytl1, originally described as a protein expressed in CD34+ cells, was recently identified as a functional secreted protein involved in chondrogenesis and cartilage development. However, our knowledge of Cytl1 is still limited. Here, we determined the Cytl1 expression pattern regulated by ovarian hormones at both the mRNA and protein levels. We found that the endometrial expression of Cytl1 in mice was low before or on the first day of gestation, significantly increased during embryo implantation, and then decreased at the end of implantation. We investigated the effects of Cytl1 on endometrial cell proliferation, and the effects on the secretion of leukemia inhibitory factor (LIF and heparin-binding epidermal growth factor (HB-EGF. We also explored the effect of Cytl1 on endometrial adhesion properties in cell-cell adhesion assays. Our findings demonstrated that Cytl1 is an ovarian hormone-dependent protein expressed in the endometrium that enhances the proliferation of HEC-1-A and RL95-2 cells, stimulates endometrial secretion of LIF and HB-EGF, and enhances the adhesion of HEC-1-A and RL95-2 cells to JAR spheroids. This study suggests that Cytl1 plays an active role in the regulation of embryo implantation.

Improving a DSM Obtained by Unmanned Aerial Vehicles for Flood Modelling

Science.gov (United States)

Mourato, Sandra; Fernandez, Paulo; Pereira, Luísa; Moreira, Madalena

2017-12-01

According to the EU flood risks directive, flood hazard map must be used to assess the flood risk. These maps can be developed with hydraulic modelling tools using a Digital Surface Runoff Model (DSRM). During the last decade, important evolutions of the spatial data processing has been developed which will certainly improve the hydraulic models results. Currently, images acquired with Red/Green/Blue (RGB) camera transported by Unmanned Aerial Vehicles (UAV) are seen as a good alternative data sources to represent the terrain surface with a high level of resolution and precision. The question is if the digital surface model obtain with this data is adequate enough for a good representation of the hydraulics flood characteristics. For this purpose, the hydraulic model HEC-RAS was run with 4 different DSRM for an 8.5 km reach of the Lis River in Portugal. The computational performance of the 4 modelling implementations is evaluated. Two hydrometric stations water level records were used as boundary conditions of the hydraulic model. The records from a third hydrometric station were used to validate the optimal DSRM. The HEC-RAS results had the best performance during the validation step were the ones where the DSRM with integration of the two altimetry data sources.

Stream profile analysis using a step backwater model for selected reaches in the Chippewa Creek basin in Medina, Wayne, and Summit Counties, Ohio

Science.gov (United States)

Straub, David E.; Ebner, Andrew D.

2011-01-01

The USGS, in cooperation with the Chippewa Subdistrict of the Muskingum Watershed Conservancy District, performed hydrologic and hydraulic analyses for selected reaches of three streams in Medina, Wayne, Stark, and Summit Counties in northeast Ohio: Chippewa Creek, Little Chippewa Creek, and River Styx. This study was done to facilitate assessment of various alternatives for mitigating flood hazards in the Chippewa Creek basin. StreamStats regional regression equations were used to estimate instantaneous peak discharges approximately corresponding to bankfull flows. Explanatory variables used in the regression equations were drainage area, main-channel slope, and storage area. Hydraulic models were developed to determine water-surface profiles along the three stream reaches studied for the bankfull discharges established in the hydrologic analyses. The HEC-RAS step-backwater hydraulic analysis model was used to determine water-surface profiles for the three streams. Starting water-surface elevations for all streams were established using normal depth computations in the HEC-RAS models. Cross-sectional elevation data, hydraulic-structure geometries, and roughness coefficients were collected in the field and (along with peak-discharge estimates) used as input for the models. Reach-averaged reductions in water-surface elevations ranged from 0.11 to 1.29 feet over the four roughness coefficient reduction scenarios.

Optimal RTP Based Power Scheduling for Residential Load in Smart Grid

Science.gov (United States)

Joshi, Hemant I.; Pandya, Vivek J.

2015-12-01

To match supply and demand, shifting of load from peak period to off-peak period is one of the effective solutions. Presently flat rate tariff is used in major part of the world. This type of tariff doesn't give incentives to the customers if they use electrical energy during off-peak period. If real time pricing (RTP) tariff is used, consumers can be encouraged to use energy during off-peak period. Due to advancement in information and communication technology, two-way communications is possible between consumers and utility. To implement this technique in smart grid, home energy controller (HEC), smart meters, home area network (HAN) and communication link between consumers and utility are required. HEC interacts automatically by running an algorithm to find optimal energy consumption schedule for each consumer. However, all the consumers are not allowed to shift their load simultaneously during off-peak period to avoid rebound peak condition. Peak to average ratio (PAR) is considered while carrying out minimization problem. Linear programming problem (LPP) method is used for minimization. The simulation results of this work show the effectiveness of the minimization method adopted. The hardware work is in progress and the program based on the method described here will be made to solve real problem.

Accuracy analysis of SRTM usage for upper Citarum River flood modeling

Directory of Open Access Journals (Sweden)

Inanda Siregar Riza

2017-01-01

Full Text Available Natural channel cross section is generally very irregular and varied, for complex cross-sections and natural cross sections no specific formula presents to express the elements of the geometric cross section of the channel. The study uses HEC-Geo RAS with Arc GIS 10 and HEC-RAS 4.1.0 for modeling and 1D hydrodynamic. The surveyed cross sections modeling is calibrated and validated with observed daily discharge. Then the surveyed data cross sections are replaced by the cross sections extracted from SRTM. Accuracy is suitability between the surveyed data cross sections with data cross sections which extracted from SRTM. Accuracy is expressed by the magnitude of the error. The ratio of simulated discharges between two models by surveyed data cross sections and SRTM data cross sections have index of performance indicator for Nash–Sutcliffe Index (NI is 0.95 and index of Root Mean Square Error (RMSE is 0.41. Index of Performance indicator for comparison of simulated discharges between models with Nash–Sutcliffe Index (NI is 0.95 and index of Root Mean Square Error (RMSE is 0.41. The results show that cross sections from SRTM can be an alternative to extract data cross sections for Upper Citarum River flood modeling.

Banking Business Models Monitor 2014: Europe

OpenAIRE

Ayadi, Rym; De Groen, Willem Pieter

2014-01-01

CEPS and the International Observatory on Financial Services Cooperatives (IOFSC) at HEC Montreal have initiated an annual monitoring exercise on banking business models in the EU. Based on their balance sheet structures, 147 European banks that account for more than 80% of the industry assets were categorised in four business models. The Monitor emphasises the ownership structures and assesses the financial and economic performance, resilience and robustness, before, during and after the fin...

The Benefits and Limitations of Hydraulic Modeling for Ordinary High Water Mark Delineation

Science.gov (United States)

2016-02-01

between two cross sections, the HEC-RAS model will not show it. If there is a sudden drop in the channel, such as a waterfall or steep rapids, the...ER D C/ CR RE L TR -1 6- 1 Wetland Regulatory Assistance Program (WRAP) The Benefits and Limitations of Hydraulic Modeling for Ordinary...client/default. Wetland Regulatory Assistance Program (WRAP) ERDC/CRREL TR-16-1 February 2016 The Benefits and Limitations of Hydraulic Modeling

The U.S. Coast Guard’s Deepwater Force Modernization Plan: Can It Be Accelerated? Will It Meet Changing Security Needs?

Science.gov (United States)

2004-01-01

Vehicle WAGB Ice Breaker WHEC High Endurance Cutter (also HEC) WIX Training Cutter WLB Seagoing Buoy Tender WLI Inland Buoy Tender WLIC Inland Construction...Foreign vessel inspections • Living marine resources protection • Marine and environmental science. The USCG website includes web pages for each mission...pp. 6–8 (available on the Web at http://www.uscg.mil/deepwater/. Mission Need. Most USCG Deepwater missions can be broken down into the functional

Testing and Validation Studies of the NSMII-Benthic Sediment Diagenesis Module

Science.gov (United States)

2016-07-01

plug in” water quality modules for HEC-RAS (Hydrologic Engineering Center- River Analysis System) and other hydrologic and hydraulic models. The...hydrologic and hydraulic models (Zhang and Johnson 2016). The NSMs are designed to be inde- pendent of the dimensionality of the spatial domain; they...fied in the above tests were reduced by 20%, 50%, and 90%, respectively. Model predictions for SOD and sediment release of NH4, NO3, H2S, CH4

Combining Hydrological Modeling and Remote Sensing Observations to Enable Data-Driven Decision Making for Devils Lake Flood Mitigation in a Changing Climate

Science.gov (United States)

Zhang, Xiaodong; Kirilenko, Andrei; Lim, Howe; Teng, Williams

2010-01-01

This slide presentation reviews work to combine the hydrological models and remote sensing observations to monitor Devils Lake in North Dakota, to assist in flood damage mitigation. This reports on the use of a distributed rainfall-runoff model, HEC-HMS, to simulate the hydro-dynamics of the lake watershed, and used NASA's remote sensing data, including the TRMM Multi-Satellite Precipitation Analysis (TMPA) and AIRS surface air temperature, to drive the model.

The averaged cross sections of natural carbon in the energy region 90-160 keV

International Nuclear Information System (INIS)

Gritzay, O.O.; Volkovetskyi, S.P.; Libman, V.A.

2012-01-01

This paper presents the results of measurements of the total cross-section of carbon in the energy region 90 - 160 keV. These results were obtained using a method of the modified filtered beams, developed in the Neutron Physics Department and implemented in the horizontal experimental channel HEC-9 at the Kyiv research reactor. The experiment was carried out using 5 modified filters. Ten values of the averaged cross-sections of carbon were obtained

Near East/North Africa Report, Number 2603

Science.gov (United States)

1982-08-17

Electricity Stations 118 Gum Arabic Belt 118 Popular Development 118 Foreign Exchange Regulating Measures 118 Tombura on HEC Policy 119...Middle East and that this underlines the need for a just solution to the Palestinian problem—a solution that guar - antees the legitimate rights of the...last months of 1360. It must be noted that prices of a number of goods & services, such as cold drinks, washing powder , some cigarettes and telephone

A Crew Exposure Study. Volume I. Offshore.

Science.gov (United States)

1982-03-15

Calcium Lignosulfonate D. Lime E. Salt F. Ammonium Acid Phosphate, (NH4)2 HPO4 IX. Filtrate Reducers A. Asphalt Emulsion B. Guar Gum C. HEC (Hydroxyethyl...Tetraphosphate 4. Caustic and Quebracho (sodium tannate) II. Thickening Agents A. Asbestos B. Xanthan Gum . III. Viscosifiers A. Bentonite 1. Sodium...Wood VII. Lubricants A. Oils B. Graphite Powder C. Soaps D. Sodium Sulfonate Asphalt VIII. Shale Control Inhibitors A. Gypsum B. Sodium Silicate C

Simulation of Flow, Sediment Transport, and Sediment Mobility of the Lower Coeur d'Alene River, Idaho

Science.gov (United States)

Berenbrock, Charles; Tranmer, Andrew W.

2008-01-01

A one-dimensional sediment-transport model and a multi-dimensional hydraulic and bed shear stress model were developed to investigate the hydraulic, sediment transport, and sediment mobility characteristics of the lower Coeur d?Alene River in northern Idaho. This report documents the development and calibration of those models, as well as the results of model simulations. The one-dimensional sediment-transport model (HEC-6) was developed, calibrated, and used to simulate flow hydraulics and erosion, deposition, and transport of sediment in the lower Coeur d?Alene River. The HEC-6 modeled reach, comprised of 234 cross sections, extends from Enaville, Idaho, on the North Fork of the Coeur d?Alene River and near Pinehurst, Idaho, on the South Fork of the river to near Harrison, Idaho, on the main stem of the river. Bed-sediment samples collected by previous investigators and samples collected for this study in 2005 were used in the model. Sediment discharge curves from a previous study were updated using suspended-sediment samples collected at three sites since April 2000. The HEC-6 was calibrated using river discharge and water-surface elevations measured at five U.S. Geological Survey gaging stations. The calibrated HEC-6 model allowed simulation of management alternatives to assess erosion and deposition from proposed dredging of contaminated streambed sediments in the Dudley reach. Four management alternatives were simulated with HEC-6. Before the start of simulation for these alternatives, seven cross sections in the reach near Dudley, Idaho, were deepened 20 feet?removing about 296,000 cubic yards of sediments?to simulate dredging. Management alternative 1 simulated stage-discharge conditions from 2000, and alternative 2 simulated conditions from 1997. Results from alternatives 1 and 2 indicated that about 6,500 and 12,300 cubic yards, respectively, were deposited in the dredged reach. These figures represent 2 and 4 percent, respectively, of the total volume of

ANALYSIS OF THE POSSIBILITY OF USING HYDROLOGICAL MODELS IN STRATEGIC ENVIRONMENTAL ASSESSMENT OF LOCAL SPATIAL DEVELOPMENT PLANS

Directory of Open Access Journals (Sweden)

Mariusz Sojka

2014-10-01

Full Text Available The paper presents the possibility of application of the hydrological model HEC-HMS in the development of a strategic environmental assessment of local spatial development plans on surface water. The practical possibility of using simulation models of catchment response to high intensity precipitation is shown on the example of the Różany Potok watercourse catchment which is subject to rapid urbanization process. The area of Różany Potok catchment is 8.1 km2 and a stream length is 5.57 km. In the years 1992–2012 there was a significant increase in impervious areas in the catchment of about 5.2 to 16%. In addition, new local spatial development plans are prepared within the catchment area. The implementation of their records may contribute to the increase in the proportion of impervious areas to over 20%. The increase in the share of impervious areas in the catchment area and traditional approach of precipitation water management can lead to doubling flood flows and increase the risk of local flooding.

Development of a 3D Stream Network and Topography for Improved Large-Scale Hydraulic Modeling

Science.gov (United States)

Saksena, S.; Dey, S.; Merwade, V.

2016-12-01

Most digital elevation models (DEMs) used for hydraulic modeling do not include channel bed elevations. As a result, the DEMs are complimented with additional bathymetric data for accurate hydraulic simulations. Existing methods to acquire bathymetric information through field surveys or through conceptual models are limited to reach-scale applications. With an increasing focus on large scale hydraulic modeling of rivers, a framework to estimate and incorporate bathymetry for an entire stream network is needed. This study proposes an interpolation-based algorithm to estimate bathymetry for a stream network by modifying the reach-based empirical River Channel Morphology Model (RCMM). The effect of a 3D stream network that includes river bathymetry is then investigated by creating a 1D hydraulic model (HEC-RAS) and 2D hydrodynamic model (Integrated Channel and Pond Routing) for the Upper Wabash River Basin in Indiana, USA. Results show improved simulation of flood depths and storage in the floodplain. Similarly, the impact of river bathymetry incorporation is more significant in the 2D model as compared to the 1D model.

Adverse effects of the SSRI antidepressant sertraline on early life stages of marine invertebrates.

Science.gov (United States)

Estévez-Calvar, Noelia; Canesi, Laura; Montagna, Michele; Faimali, Marco; Piazza, Veronica; Garaventa, Francesca

2017-07-01

Widespread contamination of coastal environments by emerging compounds includes low concentrations of pharmaceuticals. These pollutants are not currently incorporated in monitoring programs despite their effects on non-target organisms are very little documented. Among the selective serotonin reuptake inhibitor (SSRI) antidepressants, sertraline (SRT) is one of the most prescribed globally. In this work, earlier life stages of Amphibalanus amphitrite, Brachionus plicatilis and Mytilus galloprovincialis were exposed to environmental concentrations of SRT in order to study both sub-lethal and lethal responses in 24/48 h-tests. Low concentrations of SRT altered significantly swimming behavior in A. amphitrite and B. plicatilis giving 48 h-EC 50 (μg/L) of 113.88 and 282.23, respectively whereas higher values were observed for mortality and immobilization. EC 50 embryotoxicity with M. galloprovincialis was 206.80 μg/L. This work add new data about SRT ecotoxicity on marine invertebrates and confirms the applicability of behavioral endpoints to evaluate the environmental impact of antidepressants in marine organisms. Copyright © 2016 Elsevier Ltd. All rights reserved.

Assessment of Short Term Flood Operation Strategies Using Numerical Weather Prediction Data in YUVACΙK DAM Reservoir, Turkey

Science.gov (United States)

Uysal, G.; Yavuz, O.; Sensoy, A.; Sorman, A.; Akgun, T.; Gezgin, T.

2011-12-01

first step, a hydrological model with an embedded snow module is used to establish a rainfall-runoff relationship to calculate the inflow into the dam reservoir. The basin is divided into four sub-basins, along with the three elevation zones for each subbasin. Hydro-meteorological data are collected via 11 automated stations in and around the basin and a semi-distributed rainfall-runoff model, HEC-HMS, is calibrated for sub-basins. Then, HEC-ResSim is used to create simulation alternatives of reservoir system according to user defined guide curves and rules based on internal and/or external variables. The decision support modeling scenarios are tested with Numerical Weather Prediction Mesoscale Model 5 (MM5) daily total precipitation and daily average temperature data. Predicted precipitation and temperature data are compared with ground observations to examine the consistency. Predicted inflows computed by HEC-HMS are used as main forcing inputs into HEC-ResSim for the short term operation of reservoir during the flood events.

Modification of cell volume and proliferative capacity of Pseudokirchneriella subcapitata cells exposed to metal stress

International Nuclear Information System (INIS)

Machado, Manuela D.; Soares, Eduardo V.

2014-01-01

Highlights: •Metals induce morphological alterations on P. subcapitata. •Algal cell cycle consists: mother cell growth; cell division, with two nucleus divisions; release of four autospores. •Cu(II) and Cr(VI) arrest cell growth before the first nuclear division. •Cd(II) arrests cell growth after the second nuclear division but before the cytokinesis. •The approach used can be useful in the elucidation of different modes of action of pollutants. -- Abstract: The impact of metals (Cd, Cr, Cu and Zn) on growth, cell volume and cell division of the freshwater alga Pseudokirchneriella subcapitata exposed over a period of 72 h was investigated. The algal cells were exposed to three nominal concentrations of each metal: low (closed to 72 h-EC 10 values), intermediate (closed to 72 h-EC 50 values) and high (upper than 72 h-EC 90 values). The exposure to low metal concentrations resulted in a decrease of cell volume. On the contrary, for the highest metal concentrations an increase of cell volume was observed; this effect was particularly notorious for Cd and less pronounced for Zn. Two behaviours were found when algal cells were exposed to intermediate concentrations of metals: Cu(II) and Cr(VI) induced a reduction of cell volume, while Cd(II) and Zn(II) provoked an opposite effect. The simultaneous nucleus staining and cell image analysis, allowed distinguishing three phases in P. subcapitata cell cycle: growth of mother cell; cell division, which includes two divisions of the nucleus; and, release of four autospores. The exposure of P. subcapitata cells to the highest metal concentrations resulted in the arrest of cell growth before the first nucleus division [for Cr(VI) and Cu(II)] or after the second nucleus division but before the cytokinesis (release of autospores) when exposed to Cd(II). The different impact of metals on algal cell volume and cell-cycle progression, suggests that different toxicity mechanisms underlie the action of different metals

Desain Penampang Sungai Way Besai Melalui Peningkatan Kapasitas Sungai Menggunakan Softwere HEC-RAS

OpenAIRE

Utami, Tri; Purwadi, Ofik Taufik; Susilo, Gatot Eko

2016-01-01

Way Besai river is located in Sumberjaya subdistrict, West Lampung district, Lampung. It is one of the sub river from Tulang Bawang river. Way Besai river has been used as a the electric power source, known as Besai hydropower. Besai Hydropower has decreased energy supply of 40 MW from the supply optimum can reachs 90 MW. his is due to the catcment area conditions of the Way Besai rivers are "metastable" so which effected in the shallowing of the cross-section quickly. So it needs the capacit...

Decontamination and decommissioning project status of the TRIGA mark-2±3 research reactors

International Nuclear Information System (INIS)

Jung, K. J.; Baek, S. T.; Jung, W. S.; Park, S. K.; Jung, K. H.

1999-01-01

TRIGA Mark-II, the first research reactor in Korea, has operated since 1962, and the second one, TRIGA Mark-III since 1972. Both of them had their operation phased out in 1995 due to their lives and operation of the new research reactor, HANARO at the Korea Atomic Energy Research Institute (KAERI) in Taejeon. Decontamination and decommissioning (D and D) project of the TRIGA Mark-II and Mark-III was started in January 1997 and will be completed in December 2002. In the first year of the project, work was performed in preparation of the decommissioning plan, start of the environmental impact assessment and setup licensing procedure and documentation for the project with cooperation of Korea Institute of Nuclear Safety (KINS). In 1998, Hyundai Engineering Company (HEC) is the main contractor to do design and licensing documentation for the D and D of both reactors. British Nuclear Fuels plc (BNFL) is technical assisting partner of HEC. The decommissioning plan document was submitted to the Ministry of Science and Technology (MOST) for the decommissioning license in December 1998, and it expecting to be issued a license at the end of September 1999. The goal of this project is to release the reactor site and buildings as an unrestricted area. This paper summarizes current status and future plan for the D and D project

Quality of life after quitting smoking and initiating aerobic exercise.

Science.gov (United States)

Bloom, Erika Litvin; Minami, Haruka; Brown, Richard A; Strong, David R; Riebe, Deborah; Abrantes, Ana M

2017-10-01

Quitting smoking and aerobic exercise each improve health. Although smokers may be concerned that quitting smoking will reduce their quality of life (QOL), recent research has shown that cessation is associated with QOL benefits. Elements of smoking cessation interventions, such as exercise, may contribute to changes in QOL. However, it is unknown whether initiating exercise in the context of smoking cessation is associated with greater or different effects on QOL than smoking cessation alone. The current study is a secondary analysis of data from a randomized trial (n = 61) of an exercise intervention for smoking cessation. We hypothesized that smoking abstinence and engagement in exercise would have positive, additive effects on QOL at end-of-treatment, 6- and, 12-month follow-ups. Sedentary adult smokers were randomized to the exercise intervention or a health education control (HEC) group. Additionally, all participants received smoking cessation counseling and nicotine patches. Data were analyzed using actual engagement in exercise, rather than group assignment as a proxy for exercise engagement, because some HEC participants also began exercising. Abstinence was positively associated with higher total and physical health QOL at follow-up. Exercise was not associated with total QOL and only marginally associated with physical health QOL, but was positively related to overall sense of well-being. Emphasizing that smoking cessation is associated with higher QOL may help motivate smokers to initiate quit attempts.

Deriving freshwater quality criteria of sulphocyanic sodium for the protection of aquatic life in China

Institute of Scientific and Technical Information of China (English)

1998-01-01

The freshwater quality criteria of sulphocyanic sodium(NaSCN) were studied on the basis of the features of the aquaticbiota in China, and with Reference to U.S.EPA's guidelines. Acutetests were performed on twelve different domestic species todetermine 48h-EC50/96h-EC50 (or 96h-LC50) values for NaSCN. 21dsurvival-reproduction test with Daphnia magna, 60d fry-juvenilepart life stage test with Carassius auratus gibelio and 96h growthinhibition test with Lemna minor were also conducted to estimatelower chronic limit/upper chronic limit values. In the acute tests,D.magna was the most sensitive species to NaSCN followed by Tilapiamossambia, Cyprinus carpio and C.auratus gibelio in turn. The finalacute value of NaSCN was 2.699 mg/L. In the chronic tests,reproduction of daphnids were significantly reduced by NaSCN at 1.0mg/L. Acute-to-chronic ratios ranged from 5.96 to 19.1. A finalchronic value of 0.2530 mg/L was obtained and a final plant valuewas 1346 mg/L. A criterion maximum concentration (1.349 mg/L) anda criterion continuous concentration (0.2530 mg/L) were derivedrespectively. The results of this study may provide useful data toderive national WQC for NaSCN as well as the procedures of derivingWQC of other chemicals for the protection of aquatic biota in China.

Preclinical pilot study monitoring topical drug penetration and dermal bioavailability of a peptidase inhibitor from different galenic formulations into pig dermis, using cutaneous microdialysis.

Science.gov (United States)

Quist, S R; Heimburg, A; Bank, U; Mahnkopf, D; Koch, G; Gollnick, H; Täger, M; Ansorge, S

2017-08-01

Cutaneous microdialysis (CM) is an ex vivo technique that allows study of tissue chemistry, including bioavailability of actual tissue concentration of unbound drug in the interstitial fluid of the body. To test the penetration and dermal bioavailability of galenic formulations of the small-molecule IP10.C8, a dual-protease inhibitor of the dipeptidyl peptidase and aminopeptidase families. Using CM, we tested the penetration and dermal bioavailability of IP10.C8 into the dermis and subcutis of pigs, and determined the tissue concentration of IP10.C8 enzymatically, using an enzyme activity assay (substrate Gly-Pro-pNA) and high performance liquid chromatography. Dermal bioavailability was enhanced by using microemulsion or the addition of the penetration enhancer oleic acid to a hydroxyethylcellulose (HEC) gel formulation. Dermal bioavailability was also enhanced when galenic formulations were prepared with higher pH (7.5 vs. 6.5) or higher drug concentration (5% vs. 1%) in HEC gel. It seems possible, using CM for topical skin penetration testing in anaesthetized domestic pigs, to test the bioavailability of newly designed drugs. However, the experimental time is limited due to the anaesthesia, and is dependent on drug recovery. Validation of this technique for routine use is challenging, and more experiments are needed to validate this preclinical set-up. © 2017 British Association of Dermatologists.

Emodin enhances the chemosensitivity of endometrial cancer by inhibiting ROS-mediated Cisplatin-resistance.

Science.gov (United States)

Ding, Ning; Zhang, Hong; Su, Shan; Ding, Yumei; Yu, Xiaohui; Tang, Yujie; Wang, Qingfang; Liu, Peishu

2017-12-18

Background Endometrial cancer is a common cause of death in gynecological malignancies. Cisplatin is a clinically chemotherapeutic agent. However, drug-resistance is the primary cause of treatment failure. Objective Emodin is commonly used clinically to increase the sensitivity of chemotherapeutic agents, yet whether Emodin promotes the role of Cisplatin in the treatment of endometrial cancer has not been studied. Method CCK-8 kit was utilized to determine the growth of two endometrial cancer cell lines, Ishikawa and HEC-IB. The apoptosis level of Ishikawa and HEC-IB cells was detected by Annexin V / propidium iodide double-staining assay. ROS level was detected by DCFH-DA and NADPH oxidase expression. Expressions of drug-resistant genes were examined by real-time PCR and Western blotting. Results Emodin combined with Cisplatin reduced cell growth and increased the apoptosis of endometrial cancer cells. Co-treatment of Emodin and Cisplatin increased chemosensitivity by inhibiting the expression of drug-resistant genes through reducing the ROS levels in endometrial cancer cells. In an endometrial cancer xenograft murine model, the tumor size was reduced and animal survival time was increased by co-treatment of Emodin and Cisplatin. Conclusion This study demonstrates that Emodin enhances the chemosensitivity of Cisplatin on endometrial cancer by inhibiting ROS-mediated expression of drug-resistance genes. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Impact of sea level rise on tide gate function.

Science.gov (United States)

Walsh, Sean; Miskewitz, Robert

2013-01-01

Sea level rise resulting from climate change and land subsidence is expected to severely impact the duration and associated damage resulting from flooding events in tidal communities. These communities must continuously invest resources for the maintenance of existing structures and installation of new flood prevention infrastructure. Tide gates are a common flood prevention structure for low-lying communities in the tidal zone. Tide gates close during incoming tides to prevent inundation from downstream water propagating inland and open during outgoing tides to drain upland areas. Higher downstream mean sea level elevations reduce the effectiveness of tide gates by impacting the hydraulics of the system. This project developed a HEC-RAS and HEC-HMS model of an existing tide gate structure and its upland drainage area in the New Jersey Meadowlands to simulate the impact of rising mean sea level elevations on the tide gate's ability to prevent upstream flooding. Model predictions indicate that sea level rise will reduce the tide gate effectiveness resulting in longer lasting and deeper flood events. The results indicate that there is a critical point in the sea level elevation for this local area, beyond which flooding scenarios become dramatically worse and would have a significantly negative impact on the standard of living and ability to do business in one of the most densely populated areas of America.

Developing an Approach to Prioritize River Restoration using Data Extracted from Flood Risk Information System Databases.

Science.gov (United States)

Vimal, S.; Tarboton, D. G.; Band, L. E.; Duncan, J. M.; Lovette, J. P.; Corzo, G.; Miles, B.

2015-12-01

Prioritizing river restoration requires information on river geometry. In many states in the US detailed river geometry has been collected for floodplain mapping and is available in Flood Risk Information Systems (FRIS). In particular, North Carolina has, for its 100 Counties, developed a database of numerous HEC-RAS models which are available through its Flood Risk Information System (FRIS). These models that include over 260 variables were developed and updated by numerous contractors. They contain detailed surveyed or LiDAR derived cross-sections and modeled flood extents for different extreme event return periods. In this work, over 4700 HEC-RAS models' data was integrated and upscaled to utilize detailed cross-section information and 100-year modelled flood extent information to enable river restoration prioritization for the entire state of North Carolina. We developed procedures to extract geomorphic properties such as entrenchment ratio, incision ratio, etc. from these models. Entrenchment ratio quantifies the vertical containment of rivers and thereby their vulnerability to flooding and incision ratio quantifies the depth per unit width. A map of entrenchment ratio for the whole state was derived by linking these model results to a geodatabase. A ranking of highly entrenched counties enabling prioritization for flood allowance and mitigation was obtained. The results were shared through HydroShare and web maps developed for their visualization using Google Maps Engine API.

Hydraulic Geometry, GIS and Remote Sensing, Techniques against Rainfall-Runoff Models for Estimating Flood Magnitude in Ephemeral Fluvial Systems

Directory of Open Access Journals (Sweden)

Rafael Garcia-Lorenzo

2010-11-01

Full Text Available This paper shows the combined use of remotely sensed data and hydraulic geometry methods as an alternative to rainfall-runoff models. Hydraulic geometric data and boolean images of water sheets obtained from satellite images after storm events were integrated in a Geographical Information System. Channel cross-sections were extracted from a high resolution Digital Terrain Model (DTM and superimposed on the image cover to estimate the peak flow using HEC-RAS. The proposed methodology has been tested in ephemeral channels (ramblas on the coastal zone in south-eastern Spain. These fluvial systems constitute an important natural hazard due to their high discharges and sediment loads. In particular, different areas affected by floods during the period 1997 to 2009 were delimited through HEC-GeoRAs from hydraulic geometry data and Landsat images of these floods (Landsat‑TM5 and Landsat-ETM+7. Such an approach has been validated against rainfall-surface runoff models (SCS Dimensionless Unit Hydrograph, SCSD, Témez gamma HU Tγ and the Modified Rational method, MRM comparing their results with flood hydrographs of the Automatic Hydrologic Information System (AHIS in several ephemeral channels in the Murcia Region. The results obtained from the method providing a better fit were used to calculate different hydraulic geometry parameters, especially in residual flood areas.

Comparison of Chlamydia trachomatis serovar L2 growth in polarized genital epithelial cells grown in three-dimensional culture with non-polarized cells.

Science.gov (United States)

Dessus-Babus, Sophie; Moore, Cheryl G; Whittimore, Judy D; Wyrick, Priscilla B

2008-04-01

A common model for studying Chlamydia trachomatis and growing chlamydial stocks uses Lymphogranuloma venereum serovar L2 and non-polarized HeLa cells. However, recent publications indicate that the growth rate and progeny yields can vary considerably for a particular strain depending on the cell line/type used, and seem to be partially related to cell tropism. In the present study, the growth of invasive serovar L2 was compared in endometrial HEC-1B and endocervical HeLa cells polarized on collagen-coated microcarrier beads, as well as in HeLa cells grown in tissue culture flasks. Microscopy analysis revealed no difference in chlamydial attachment/entry patterns or in inclusion development throughout the developmental cycle between cell lines. Very comparable growth curves in both cell lines were also found using real-time PCR analysis, with increases in chlamydial DNA content of 400-500-fold between 2 and 36 h post-inoculation. Similar progeny yields with comparable infectivity were recovered from HEC-1B and HeLa cell bead cultures, and no difference in chlamydial growth was found in polarized vs. non-polarized HeLa cells. In conclusion, unlike other C. trachomatis strains such as urogenital serovar E, invasive serovar L2 grows equally well in physiologically different endometrial and endocervical environments, regardless of the host cell polarization state.

Study of the influence of platinum, palladium and rhodium on duckweed (Lemna minor).

Science.gov (United States)

Bednarova, Ivana; Mikulaskova, Hana; Havelkova, Barbora; Strakova, Lenka; Beklova, Miroslava; Sochor, Jiri; Hynek, David; Adam, Vojtech; Kizek, Rene

2014-01-01

Road traffic pollutants and the residues of cytostatics that are widely used in anti-cancer therapy are a significant sources of platinum group elements (PGE; Pt, Pd and Rh) in environment. These metals can migrate into sewage and thus pollute surface waters. The purpose of our study was to evaluate the effect of PtCl4 on the antioxidant and enzymatic activity of duckweed (Lemna minor), a bioindicator of the aquatic environment. The study was performed using a 7-day conventional test based on the OECD 221 (CSN EN ISO 20079)--Lemna sp. Growth Inhibition Test. We also conducted a microbiotest to analyse the effects of PtC4, PdCl2 and RhCl3 on the morphology and vegetative growth of colonies of this plant and compared their inhibitory effects during the microbiotest. We observed inhibition of colony growth and clear morphological changes. Antioxidant and enzymatic activities increased with platinum doses increased. The 168hEC50 of PtCl4 was 12.16 μM (95% confidence interval = 9.88-14.44) and the 168hEC50 of PdCl2 was 50.39 (95% confidence interval = 23.83-76.96). The greatest inhibition of growth by RhCl3 was observed at 25 μM. The obtained results suggest that L. minor phytotoxicity tests should be widely used in the biomonitoring.

Assessment of Hydraulic Conditions Supporting the Recruitment of Asian Carp in the Illinois Waterway - A Case Study Using Known Spawning Events of 2015

Science.gov (United States)

Soong, D. T.; Garcia, T.; Duncker, J.; Zhu, Z.; Butler, S.; Diana, M.; Wahl, D.

2016-12-01

The upstream movement of Asian carp in the Illinois Waterway poses a potential threat to the Great Lakes. If established within the Great Lakes, Asian carp may disrupt the food web and harm the ecosystems of the Great Lakes. Understanding the Asian carp reproduction, including the timing and locations of adult spawning and the transport and dispersal of eggs and larvae, is essential information for managing the Asian carp population in the Illinois Waterway. The Fluvial Egg Drift Simulator (FluEgg) model, a Lagrangian particle tracking model, has been used to study the transport and dispersal of eggs and larvae. The FluEgg model inputs are water temperature and hydraulic properties. At present, field measured or modeled hydraulics from steady-state simulations have been used in FluEgg modeling and the applications have shown useful results for evaluating Asian carp reproduction in the Illinois Waterway. However, there is a need to use data based on more representative time-variable hydraulic conditions from spawning to the time larvae reach the Gas Bladder Inflation Stage (GBI). The GBI stage is critical because that is the stage when the young fish seek nursery habitat. In June 2015, Asian carp spawning was observed at two locations along the Illinois Waterway, one below Starved Rock Lock and Dam near Utica, and the one in the La Grange Pool near Havana, Illinois. This study analyzes how hydraulic modeling can improve the predictability of the FluEgg model. An unsteady HEC-RAS hydraulic model of the Illinois Waterway from Brandon Road Lock and Dam to Grafton, Illinois was used to reproduce the June 2015 flood event. Hydraulic data from HEC-RAS modeling, including predicted spatial and temporal discharge, water depth, and shear velocity; and measured water temperature data were used as input to the FluEgg model. FluEgg simulation results illustrate the downstream drifting of eggs and larvae until reaching the GBI stage. These simulation results can be analyzed

Metallic vapor supplying by the electron bombardment for a metallic ion production with an ECR ion source

Energy Technology Data Exchange (ETDEWEB)

Kitagawa, Atsushi; Sasaki, Makoto; Muramatsu, Masayuki [National Inst. of Radiological Sciences, Chiba (Japan); Jincho, Kaoru; Sasaki, Noriyuki; Sakuma, Tetsuya; Takasugi, Wataru; Yamamoto, Mitsugu [Accelerator Engineering Corporation, Chiba (Japan)

2001-11-19

To produce the metallic ion beam for the injection into the Heavy Ion Medical Accelerator in Chiba (HIMAC) at the National Institute of Radiological Sciences (NIRS), a new gas supply method has been developed for an 18 GHz ECR ion source (NIRS-HEC). A metallic target rod at a high positive potential is melted by the electron bombardment technique. The evaporated gas with a maximum flow rate of 50A/sec is supplied into the ECR plasma in case of Fe metal. (author)

Metallic vapor supplying by the electron bombardment for a metallic ion production with an ECR ion source

International Nuclear Information System (INIS)

Kitagawa, Atsushi; Sasaki, Makoto; Muramatsu, Masayuki; Jincho, Kaoru; Sasaki, Noriyuki; Sakuma, Tetsuya; Takasugi, Wataru; Yamamoto, Mitsugu

2001-01-01

To produce the metallic ion beam for the injection into the Heavy Ion Medical Accelerator in Chiba (HIMAC) at the National Institute of Radiological Sciences (NIRS), a new gas supply method has been developed for an 18 GHz ECR ion source (NIRS-HEC). A metallic target rod at a high positive potential is melted by the electron bombardment technique. The evaporated gas with a maximum flow rate of 50A/sec is supplied into the ECR plasma in case of Fe metal. (author)

Two-Dimensional Flow Modeling: Proceedings of the National U.S. Army Corps of Engineers-Sponsored Seminar on the Two-Dimensional Flow Modeling (1st), 7-9 July 1981,

Science.gov (United States)

1982-03-01

Niederauer (Enerly, Inc.), Lee Butler (WES), Danny Fread (NOAA). Theodor Strelkoff (Hydraulic Enuineering), Robert MacArthur (HEC), Warren Mellema (4RD), Jaime ...Mississippi, Sabine , and Neches Rivers as shown in Figures 1 and 2. Work is on-going to gradually extend this service to other Gulf Coast rivers in Texas...MEXICO FIG. 2-HURRICANE STORM SURGE FORECASTING OF SABINE AND NECHES RIVERS 16 DAM -Z - PLAN VIEW- SEC. VIEW f-f FIG. 3- DAM-BREAK FLOOD ONTO A VERY WIDE

Comparison of Chlamydia trachomatis serovar L2 growth in polarized genital epithelial cells grown in three-dimensional culture with non-polarized cells

OpenAIRE

Dessus-Babus, Sophie; Moore, Cheryl G.; Whittimore, Judy D.; Wyrick, Priscilla B.

2008-01-01

A common model for studying Chlamydia trachomatis and growing chlamydial stocks uses Lymphogranuloma venereum serovar L2 and non-polarized HeLa cells. However, recent publications indicate that the growth rate and progeny yields can vary considerably for a particular strain depending on the cell line/type used, and seem to be partially related to cell tropism. In the present study, the growth of invasive serovar L2 was compared in endometrial HEC-1B and endocervical HeLa cells polarized on co...

Sedimentation Impacts Modeling for the Lower Elwha River

Science.gov (United States)

Beggs, M.; Kosaka, M.; Sigel, A.; Vandermause, R.; Lauer, J. W.

2012-12-01

The removal of Glines Canyon and Elwha Dams from the Elwha River, northwest Washington, is intended to restore natural geomorphic and ecological processes to the Elwha River basin. Prior to the start of dam removal, over 16 million cubic meters of sediment had accumulated in the reservoirs above the two dams. As dam removal progresses, a portion of this sediment will erode and then be deposited on the downstream river bed and floodplain. To address uncertainty in downstream response to the project, the United States Bureau of Reclamation is implementing an adaptive management plan that relies upon continuous monitoring of water levels at a set of stream gages along the river. To interpret the monitoring data and allow for rapid assessment of the rate of downstream sedimentation, we developed rating curves at several locations along the lower Elwha River. The curves consider a range of possible sedimentation scenarios, each involving different sedimentation levels and/or locations. One scenario considers sedimentation primarily in the river channel, another considers sedimentation primarily on the floodplain, and a third considers both possibilities in tandem. We modeled these scenarios using two separate approaches. First, we modified the cross sections in an existing U.S. Army Corps of Engineers HEC-RAS model to represent possible changes associated with geomorphic adjustment to the dam removals. In-channel sedimentation was assumed to occur as a constant fraction of the bankfull depth at any given section, thereby focusing geomorphic change in relatively deep pool areas. In the HEC-RAS model, off-channel sedimentation was assumed uniform. The HEC-RAS model showed that both low-flow and flood hydraulics are much more sensitive to plausible levels of in-channel sedimentation than to plausible levels of overbank sedimentation. The wide floodplain, complex secondary channels, and geomorphic evolution since the original cross sections were surveyed raise some

Transmutation of fullerenes.

Science.gov (United States)

Cross, R James; Saunders, Martin

2005-03-09

Fullerenes were pyrolyzed by subliming them into a stream of flowing argon gas and then passing them through an oven heated to approximately 1000 degrees C. C(76), C(78), and C(84) all readily lost carbons to form smaller fullerenes. In the case of C(78), some isomerization was seen. Pyrolysis of (3)He@C(76) showed that all or most of the (3)He was lost during the decomposition. C(60) passes through the apparatus with no decomposition and no loss of helium.

Dielectric heating. Industrial applications; Chauffage dielectrique. Applications industrielles

Energy Technology Data Exchange (ETDEWEB)

Roussy, G. [Nancy-1 Univ. Henri Poincare, Dir. de Recherche 54 (France); Rochas, J.F. [Societe Sairem, 75 - Paris (France); Oberlin, C. [Electricite de France (EDF), Div. de Recherche, 75 - Paris (France)

2003-11-01

The heating of insulating or badly power conducting products using high frequency (HF) electromagnetic waves and microwaves (MW) is used in several industrial applications. This article presents some examples of conventional or recent applications of dielectric heating in the industry: 1 - selection criteria between HF and MW heating systems; 2 - HF applications: traditional applications (wood forming and sticking, welding of thermoplastic materials, drying of textile materials, correction of the humidity profile in the paper industry, end-baking of biscuits in the food industry), recent applications (over-moulding of automotive glazing materials, gluing and moulding of plastic parts in the automotive industry, drying of the coating of textile ropes), innovative applications; 3 - microwave applications: traditional applications (moderating of frozen meat by 915 MHz microwaves, drying of coatings on polystyrene or sand core models for foundry, pre-vulcanization of rubber sections, 2450 MHz pasteurization of pumpable products with morsels), examples of recent applications (continuous dehydration in vacuum, MW assisted granulator-dryers in the pharmaceutical industry, decontamination of hospital wastes), examples of innovative applications in the chemical sector, applications in progress; 4 - conclusion. (J.S.)

Protecting water resources from pollution in the Lake Badovc

Energy Technology Data Exchange (ETDEWEB)

Avdullahi, Sabri; Fejza, Islam; Tmava, Ahmet [Faculty of Geosciences and Technology, University of Prishtina, Str. Parku Industrial, 40000 Mitrovic, Republic of Kosova

2012-07-01

In recent years, the international community has witnessed incidence of climate variability and human activities. The objective of this paper is protecting water resources from pollution in the catchments area of Lake Badovc. The catchments area of the Lake Badovc has a size of 109 km² and the active storage volume of the lake is assessed to 26.4 Mill.m3. Around 28% of the total population of Municipality of Prishtina supply with drinking water from Lake Badovc. The hydrologic modelling system used, is HEC-HMS developed by the Hydrologic Engineering Centre of the US Corps of Engineers. The model is designed to simulate the rainfall-runoff processes of catchments areas and is applicable to a wide range of geographic areas.Water samples are taken from two streams reach Lake Badovc and from the lake in three different depths (5m, 10m and 15m) at different locations. Concerning the environment impact more than 140 interviews were conducted and questionnaires filled in the period October-November for Mramor area, concentrating on the most important issues: building, water supply, wastewater disposal and west disposal.

Improving Watershed-Scale Hydrodynamic Models by Incorporating Synthetic 3D River Bathymetry Network

Science.gov (United States)

Dey, S.; Saksena, S.; Merwade, V.

2017-12-01

Digital Elevation Models (DEMs) have an incomplete representation of river bathymetry, which is critical for simulating river hydrodynamics in flood modeling. Generally, DEMs are augmented with field collected bathymetry data, but such data are available only at individual reaches. Creating a hydrodynamic model covering an entire stream network in the basin requires bathymetry for all streams. This study extends a conceptual bathymetry model, River Channel Morphology Model (RCMM), to estimate the bathymetry for an entire stream network for application in hydrodynamic modeling using a DEM. It is implemented at two large watersheds with different relief and land use characterizations: coastal Guadalupe River basin in Texas with flat terrain and a relatively urban White River basin in Indiana with more relief. After bathymetry incorporation, both watersheds are modeled using HEC-RAS (1D hydraulic model) and Interconnected Pond and Channel Routing (ICPR), a 2-D integrated hydrologic and hydraulic model. A comparison of the streamflow estimated by ICPR at the outlet of the basins indicates that incorporating bathymetry influences streamflow estimates. The inundation maps show that bathymetry has a higher impact on flat terrains of Guadalupe River basin when compared to the White River basin.

Thiolated hydroxyethyl cellulose: design and in vitro evaluation of mucoadhesive and permeation enhancing nanoparticles.

Science.gov (United States)

Rahmat, Deni; Müller, Christiane; Barthelmes, Jan; Shahnaz, Gul; Martien, Ronny; Bernkop-Schnürch, Andreas

2013-02-01

Within this study, HEC-cysteamine nanoparticles with free thiol groups in the range of 117-1548 μmol/g were designed and characterized. Nanoparticles were generated via ionic gelation of the cationic polymer with tripolyphosphate (TPP) followed by covalent crosslinking via disulfide bond formation using H2O2 as oxidant. The mean diameter of the particles was in the range of 270-360 nm, and zeta potential was determined to be +4 to +10 mV. Nanoparticles were evaluated in terms of mucoadhesive, permeation enhancing, and biocompatible properties as well as biodegradability. The particles remained attached to porcine intestinal mucosa up to 70% after 3h of incubation. The more nanoparticles were oxidized; however, the less were their mucoadhesive properties. Nanoparticles applied in a concentration of 0.5% (m/v) with the highest content of free thiol groups improved the transport of fluorescein isothiocyanate dextran 4 (FD4) across Caco-2 cell monolayer 3.94-fold in comparison with control (buffer). In addition, the transport of FD4 was even 1.84-fold enhanced in the presence of 0.5% (m/v) nanoparticles with the lowest free thiol group content. The higher the disulfide bond content within nanoparticles was, to a lower degree nanoparticles were hydrolyzed by cellulase. None of these nanoparticles showed pronounced cytotoxicity. Accordingly, HEC-cysteamine could be a promising excipient for nanoparticulate delivery systems for poorly absorbed drugs. Copyright © 2012 Elsevier B.V. All rights reserved.

A Spanner in the Works: Human–Elephant Conflict Complicates the Food–Water–Energy Nexus in Drylands of Africa

Directory of Open Access Journals (Sweden)

Mwangi Githiru

2017-10-01

Full Text Available The two major conservation issues for drylands of Africa are habitat loss or degradation and habitat fragmentation, largely from agriculture, charcoal production, and infrastructural development. A key question for management is how these landscapes can retain their critical ecological functions and services, while simultaneously supporting resilient livelihoods. It is a clear nexus question involving food (agriculture, water, and energy (fuelwood, which is complicated by human–wildlife conflicts. While these could appear disparate issues, they are closely connected in dryland forest landscapes of Africa where elephants occur close to areas of human habitation. For instance, crop failure, whether due to weather or wildlife damage, is a key driver for rural farmers seeking alternative livelihoods and incomes, one of the commonest being charcoal production. Similarly, heavy reliance on wood-based energy often leads to degradation of wildlife habitat, which heightens competition with wildlife for food and water, increasing the possibility of crop-raiding. So, for multifunctional landscapes where elephants occur in close proximity with humans, any food–water–energy nexus activities toward achieving sustainability and resilience should consider human–elephant conflicts (HECs. Here, we broach these food–water–energy nexus issues with a focus on dryland areas of Africa and HECs. We highlight an ongoing study attempting to address this nexus holistically by employing a climate-smart agriculture (CSA and agro-forestry based design, augmented by an elephant deterrent study and an eco-charcoal production venture.

MODELACIÓN DE TRÁNSITO DE CRECIENTES EN EL RÍO ABURRÁ-MEDELLÍN PARA UNA PROPUESTA DE SU RESTAURACIÓN

Directory of Open Access Journals (Sweden)

Andrés Felipe Marín Muñoz

Full Text Available La cuenca del río Aburrá-Medellín está localizada sobre la cordillera central, en el departamento de Antioquia. El río nace en el Alto de San Miguel en el municipio de Caldas y atraviesa 10 municipios hasta finalmente unirse con el río Grande, donde cambia de nombre a río Porce. El tramo del río Aburrá-Medellín comprendido entre el nacimiento y su entrada al municipio de Caldas ha sufrido grandes alteraciones en sus condiciones naturales debido a la explotación de materiales para construcción. También se ha visto afectado por la deforestación de su cuenca y la introducción de fauna no nativa que han afectado la disponibilidad del recurso y su calidad. El proyecto tiene como objetivo formular alternativas de restauración para algunos tramos del río Medellín que presentan un alto grado de afectación antrópica. Para el análisis hidrológico e hidráulico se utilizaron los programas HEC-HMS, HEC-RAS e Iber como soporte técnico para establecer las medidas de restauración. Se espera que los resultados de este proyecto sirvan como apoyo para otros de mayor alcance como el POMCA, el proyecto Bio 2030 y los Parques del Río Medellín.

Modeling Flood & Drought Scenario for Water Management in Porali River Basin, Balochistan

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Shoaib Ahmed

2013-12-01

Full Text Available Recent history shows that floods have become a frequently occurring disaster in Balochistan, especially during monsoon season. Two rivers, river Porali and river Kud overflows, inundating its banks and causing destruction to cultivated land and property. This study is an attempt to identify flood prone areas of Porali river basin for future flood scenario and propose possible reservoir locations for excess flood water storage. Computer-based models Hydrological Simulation Program-FORTRAN (HSPF and HEC-river analysis system (HEC-RAS are used as tools to simulate existing and future flood and drought scenarios. Models are calibrated and validated using data from 3 weather stations, namely Wadh, Bela, and Uthal and stream flow data from two gauging stations. The highest and the lowest 10 years of precipitation data are extracted, from historic dataset of all stations, to attain future flooding and drought scenarios, respectively. Flood inundation map is generated highlighting agricultural prone land and settlements of the watershed. Using Digital Elevation Model (DEM and volume of water calculated from the flood scenario, possible locations for reservoirs are marked that can store excess water for the use in drought years. Flow and volume of water has also been simulated for drought scenario. Analyses show that 3 × 109 m3 of water available due to immense flooding that is sufficient for the survival for one drought year, as the volume of water for latter scenario is 2.9 × 108m3.

Assessment Approach for Identifying Compatibility of Restoration Projects with Geomorphic and Flooding Processes in Gravel Bed Rivers.

Science.gov (United States)

DeVries, Paul; Aldrich, Robert

2015-08-01

A critical requirement for a successful river restoration project in a dynamic gravel bed river is that it be compatible with natural hydraulic and sediment transport processes operating at the reach scale. The potential for failure is greater at locations where the influence of natural processes is inconsistent with intended project function and performance. We present an approach using practical GIS, hydrologic, hydraulic, and sediment transport analyses to identify locations where specific restoration project types have the greatest likelihood of working as intended because their function and design are matched with flooding and morphologic processes. The key premise is to identify whether a specific river analysis segment (length ~1-10 bankfull widths) within a longer reach is geomorphically active or inactive in the context of vertical and lateral stabilities, and hydrologically active for floodplain connectivity. Analyses involve empirical channel geometry relations, aerial photographic time series, LiDAR data, HEC-RAS hydraulic modeling, and a time-integrated sediment transport budget to evaluate trapping efficiency within each segment. The analysis segments are defined by HEC-RAS model cross sections. The results have been used effectively to identify feasible projects in a variety of alluvial gravel bed river reaches with lengths between 11 and 80 km and 2-year flood magnitudes between ~350 and 1330 m(3)/s. Projects constructed based on the results have all performed as planned. In addition, the results provide key criteria for formulating erosion and flood management plans.

The Use of Rainfall Variability in Flood Countermeasure Planning

Directory of Open Access Journals (Sweden)

Iis Catur Wulan Dhari

2017-09-01

Full Text Available One of the impacts of climate change is the unpredictable shifting of seasons and rainfall patterns which caused flooding. Rejoso Watershed in Pasuruan Regency is one of the watersheds that suffer from flooding almost every year due to watershed degradation characterized by land conversion and changes in the hydrological behavior including the extreme rainfall pattern. This research was aimed to investigate the effect of rainfall variability on runoff and floodwater level profile along the river channel to provide technical and non-technical recommendation for handling flood problems. The hydrological analysis was performed using HEC-HMS version 4.0 software and the hydraulic analysis was conducted using HEC-RAS version 5.0.3 software. Several variations of extreme rainfall pattern were applied in the rainfall-runoff calculation to determine the representative flood discharges that will be used as input to the hydraulic simulation for evaluating the characteristics of flood water level. The result of the research shows that rainfall with the same depth yet varies in duration and starting time generate different flood hydrographs. Rejoso River could not store flood discharge with return period of 2 years with peak discharge of 201.46 m3/s that causing overflow along the stream. The recommendation to handle flood problems is by normalization, which could reduce the overtopping at several river reaches of 4,927 m, while the combination of normalization and embankment could reduce 7,843 m from the existing river length of 12,396 m.

A coupled hydrological-hydraulic flood inundation model calibrated using post-event measurements and integrated uncertainty analysis in a poorly gauged Mediterranean basin

Science.gov (United States)

Hdeib, Rouya; Abdallah, Chadi; Moussa, Roger; Colin, Francois

2017-04-01

Developing flood inundation maps of defined exceedance probabilities is required to provide information on the flood hazard and the associated risk. A methodology has been developed to model flood inundation in poorly gauged basins, where reliable information on the hydrological characteristics of floods are uncertain and partially captured by the traditional rain-gauge networks. Flood inundation is performed through coupling a hydrological rainfall-runoff (RR) model (HEC-HMS) with a hydraulic model (HEC-RAS). The RR model is calibrated against the January 2013 flood event in the Awali River basin, Lebanon (300 km2), whose flood peak discharge was estimated by post-event measurements. The resulting flows of the RR model are defined as boundary conditions of the hydraulic model, which is run to generate the corresponding water surface profiles and calibrated against 20 post-event surveyed cross sections after the January-2013 flood event. An uncertainty analysis is performed to assess the results of the models. Consequently, the coupled flood inundation model is simulated with design storms and flood inundation maps are generated of defined exceedance probabilities. The peak discharges estimated by the simulated RR model were in close agreement with the results from different empirical and statistical methods. This methodology can be extended to other poorly gauged basins facing common stage-gauge failure or characterized by floods with a stage exceeding the gauge measurement level, or higher than that defined by the rating curve.

Assessment Approach for Identifying Compatibility of Restoration Projects with Geomorphic and Flooding Processes in Gravel Bed Rivers

Science.gov (United States)

DeVries, Paul; Aldrich, Robert

2015-08-01

A critical requirement for a successful river restoration project in a dynamic gravel bed river is that it be compatible with natural hydraulic and sediment transport processes operating at the reach scale. The potential for failure is greater at locations where the influence of natural processes is inconsistent with intended project function and performance. We present an approach using practical GIS, hydrologic, hydraulic, and sediment transport analyses to identify locations where specific restoration project types have the greatest likelihood of working as intended because their function and design are matched with flooding and morphologic processes. The key premise is to identify whether a specific river analysis segment (length ~1-10 bankfull widths) within a longer reach is geomorphically active or inactive in the context of vertical and lateral stabilities, and hydrologically active for floodplain connectivity. Analyses involve empirical channel geometry relations, aerial photographic time series, LiDAR data, HEC-RAS hydraulic modeling, and a time-integrated sediment transport budget to evaluate trapping efficiency within each segment. The analysis segments are defined by HEC-RAS model cross sections. The results have been used effectively to identify feasible projects in a variety of alluvial gravel bed river reaches with lengths between 11 and 80 km and 2-year flood magnitudes between ~350 and 1330 m3/s. Projects constructed based on the results have all performed as planned. In addition, the results provide key criteria for formulating erosion and flood management plans.

Flood Risk Management in Remote and Impoverished Areas—A Case Study of Onaville, Haiti

Directory of Open Access Journals (Sweden)

Valentin Heimhuber

2015-07-01

Full Text Available In this study, geographic information system (GIS-based hydrologic and hydraulic modeling was used to perform a flood risk assessment for Onaville, which is a fairly new, rapidly growing informal settlement that is exposed to dangerous flash-flood events. Since records of historic floods did not exist for the study area, design storms with a variety of significant average return intervals (ARIs were derived from intensity-duration-frequency (IDF curves and transformed into design floods via rainfall-runoff modeling in hydrologic engineering center’s hydrologic modeling system (HEC-HMS. The hydraulic modeling software hydrologic engineering center’s river analysis system (HEC-RAS was used to perform one-dimensional, unsteady-flow simulations of the design floods in the Ravine Lan Couline, which is the major drainage channel of the area. Topographic data comprised a 12 m spatial resolution TanDEM-X digital elevation model (DEM and a 30 cm spatial resolution DEM created with mapping drones. The flow simulations revealed that large areas of the settlement are currently exposed to flood hazard. The results of the hydrologic and hydraulic modeling were incorporated into a flood hazard map which formed the basis for flood risk management. We present a grassroots approach for preventive flood risk management on a community level, which comprises the elaboration of a neighborhood contingency plan and a flood risk awareness campaign together with representatives of the local community of Onaville.

Gas Sorption, Diffusion, and Permeation in Nafion

KAUST Repository

Mukaddam, Mohsin Ahmed

2015-12-22

The gas permeability of dry Nafion films was determined at 2 atm and 35 °C for He, H2, N2, O2, CO2, CH4, C2H6, and C3H8. In addition, gas sorption isotherms were determined by gravimetric and barometric techniques as a function of pressure up to 20 atm. Nafion exhibited linear sorption uptake for low-solubility gases, following Henry’s law, and convex behavior for highly sorbing condensable gases, indicating rubber-like behavior at 35 °C. XRD results demonstrated that Nafion contains bimodal amorphous chain domains with average d-spacing values of 2.3 and 5.3 Å. Only helium and hydrogen showed relatively high gas permeability of 37 and 7 barrers, respectively; all other gases exhibited low permeability that decreased significantly as penetrant size increased. Dry Nafion was characterized by extraordinarily high selectivities: He/H2 = 5.2, He/CH4 = 445, He/C2H6 = 1275, He/C3H8 = 7400, CO2/CH4 = 28, CO2/C2H6 = 79, CO2/C3H8 = 460, H2/CH4 = 84, H2/C2H6 = 241, and H2/C3H8 = 1400. These high selectivities could make Nafion a potential candidate membrane material for dry feeds for helium recovery and carbon dioxide separation from natural gas and removal of higher hydrocarbons from hydrogen-containing refinery gases.

D¯0D0* (D0D¯0*) system in QCD-improved many body potential

Science.gov (United States)

Jamil, M. Imran; Masud, Bilal; Akram, Faisal; Sohail Gilani, S. M.

2017-01-01

For a system of current interest (composed of charm, anticharm and a pair of light quarks), we show trends in phenomenological implications of QCD-based improvements to a simple quark model treatment. We employ a resonating group method to render this difficult four-body problem manageable. We use a quadratic confinement so as to be able to improve beyond the Born approximation. We report the position of the pole corresponding to the D¯0D0* molecule for the best fit of a model parameter to the relevant QCD simulations. We point out the interesting possibility that the pole can be shifted to 3872 MeV by introducing another parameter I 0 that changes the strength of the interaction in this one component of X(3872). The revised value of this second parameter can guide future trends in modeling of the full exotic meson X(3872). We also report the changes with I 0 in the S-wave spin averaged cross sections for D¯0D0* ⟶ ωJ/ψ and D¯0D0* ⟶ ρJ/ψ. These cross sections are important regarding the study of QGP (quark gluon plasma). BM and FA acknowledge the support of PU research (D/605/Est.I Sr. 20 Project 2014-15, D/34/Est.1 Sr. 109 Project 2013-14), SG is thankful to the Higher Education Commission (HEC) of Pakistan for its financial support through (17-5-4(Ps3-128) HEC/Sch/2006)

Curcumin exhibits anti-tumor effect and attenuates cellular migration via Slit-2 mediated down-regulation of SDF-1 and CXCR4 in endometrial adenocarcinoma cells.

Science.gov (United States)

Sirohi, Vijay Kumar; Popli, Pooja; Sankhwar, Pushplata; Kaushal, Jyoti Bala; Gupta, Kanchan; Manohar, Murli; Dwivedi, Anila

2017-06-01

Although curcumin shows anti-proliferative and anti-inflammatory activities in various cancers, the effect of curcumin on cellular migration in endometrial adenocarcinoma cells remains to be understood. The current investigation was aimed to explore the anti-proliferative and anti-migratory effects of curcumin and its mechanism of action in endometrial cancer cells. Our in-vitro and in-vivo experimental studies showed that curcumin inhibited the proliferation of endometrial cancer cells and suppressed the tumor growth in Ishikawa xenograft mouse model. Curcumin induced ROS-mediated apoptosis in endometrial cancer cells. Curcumin suppressed the migration rate of Ishikawa and Hec-1B cells as analyzed by scratch wound assay. In transwell migration studies, knock down of Slit-2 reversed the anti-migratory effect of curcumin in these cell lines. Curcumin significantly up-regulated the expression of Slit-2 in Ishikawa, Hec-1B and primary endometrial cancer cells while it down-regulated the expression of stromal cell-derived factor-1 (SDF-1) and CXCR4 which in turn, suppressed the expression of matrix metallopeptidases (MMP) 2 and 9, thus attenuating the migration of endometrial cancer cells. In summary, we have demonstrated that curcumin has inhibitory effect on cellular migration via Slit-2 mediated down-regulation of CXCR4, SDF-1, and MMP2/MMP9 in endometrial carcinoma cells. These findings helped explore the role of Slit-2 in endometrial cancer cells. Copyright © 2017 Elsevier Inc. All rights reserved.

Exploring the Behavior and Metabolic Transformations of SeNPs in Exposed Lactic Acid Bacteria. Effect of Nanoparticles Coating Agent

Directory of Open Access Journals (Sweden)

Maria Palomo-Siguero

2017-08-01

Full Text Available The behavior and transformation of selenium nanoparticles (SeNPs in living systems such as microorganisms is largely unknown. To address this knowledge gap, we examined the effect of three types of SeNP suspensions toward Lactobacillus delbrueckii subsp. bulgaricus LB-12 using a variety of techniques. SeNPs were synthesized using three types of coating agents (chitosan (CS-SeNPs, hydroxyethyl cellulose (HEC-SeNPs and a non-ionic surfactant, surfynol (ethoxylated-SeNPs. Morphologies of SeNPs were all spherical. Transmission electron microscopy (TEM was used to locate SeNPs in the bacteria. High performance liquid chromatography (HPLC on line coupled to inductively coupled plasma mass spectrometry (ICP-MS was applied to evaluate SeNP transformation by bacteria. Finally, flow cytometry employing the live/dead test and optical density measurements at 600 nm (OD600 were used for evaluating the percentages of bacteria viability when supplementing with SeNPs. Negligible damage was detected by flow cytometry when bacteria were exposed to HEC-SeNPs or CS-SeNPs at a level of 10 μg Se mL−1. In contrast, ethoxylated-SeNPs were found to be the most harmful nanoparticles toward bacteria. CS-SeNPs passed through the membrane without causing damage. Once inside, SeNPs were metabolically transformed to organic selenium compounds. Results evidenced the importance of capping agents when establishing the true behavior of NPs.

Prevalence and trends of cellulosics in pharmaceutical dosage forms.

Science.gov (United States)

Mastropietro, David J; Omidian, Hossein

2013-02-01

Many studies have shown that cellulose derivatives (cellulosics) can provide various benefits when used in virtually all types of dosage forms. Nevertheless, the popularity of their use in approved drug products is rather unknown. This research reports the current prevalence and trends of use for 15 common cellulosics in prescription drug products. The cellulosics were powdered and microcrystalline cellulose (MCC), ethyl cellulose, hydroxypropyl cellulose (HPC), hydroxyethyl cellulose (HEC), hypromellose (HPMC), HPMC phthalate, HPMC acetate succinate, cellulose acetate (CA), CA phthalate, sodium (Na) and calcium (Ca) carboxymethylcellulose (CMC), croscarmellose sodium (XCMCNa), methyl cellulose, and low substituted HPC. The number of brand drug products utilizing each cellulosics was determined using the online drug index Rxlist. A total of 607 brand products were identified having one or more of the cellulosics as an active or inactive ingredient. An array of various dosage forms was identified and revealed HPMC and MCC to be the most utilized cellulosics in all products followed by XCMCNa and HPC. Many products contained two or more cellulosics in the formulation (42% containing two, 23% containing three, and 4% containing 4-5). The largest combination occurrence was HPMC with MCC. The use of certain cellulosics within different dosage form types was found to contain specific trends. All injectables utilized only CMCNa, and the same with all ophthalmic solutions utilizing HPMC, and otic suspensions utilizing HEC. Popularity and trends regarding cellulosics use may occur based on many factors including functionality, safety, availability, stability, and ease of manufacturing.

Experiment of bias probe method at NIRS-18 GHz ECR ion source

Energy Technology Data Exchange (ETDEWEB)

Jincho, Kaoru; Yamamoto, Mitsugu; Okada, Takanori; Takasugi, Wataru; Sakuma, Tetsuya; Miyoshi, Tomohiro [Accelerator Engineering Corp., Chiba (Japan); Kitagawa, Atsushi; Muramatsu, Masayuki [National Inst. of Radiological Sciences, Chiba (Japan); Biri, Sandor [Institute of Nuclear Research (ATOMKI), Debrecen (Hungary)

2000-11-01

An 18 GHz ECR ion source (NIRS-HEC) has been developed to produce highly charged heavy ions from Ar to Xe. In order to increase the beam intensity of highly charged ion, we tried a technique of supplying cold electrons into the ECR plasma. In this paper, enhancement of the beam intensity is discussed in detail. The bias voltage is applied on the probe to repel cold electrons which flow from a plasma. The output beam current is 130 e{mu}A for Ar{sup 11+}. (J.P.N.)

Experiment of bias probe method at NIRS-18 GHz ECR ion source

International Nuclear Information System (INIS)

Jincho, Kaoru; Yamamoto, Mitsugu; Okada, Takanori; Takasugi, Wataru; Sakuma, Tetsuya; Miyoshi, Tomohiro; Kitagawa, Atsushi; Muramatsu, Masayuki; Biri, Sandor

2000-01-01

An 18 GHz ECR ion source (NIRS-HEC) has been developed to produce highly charged heavy ions from Ar to Xe. In order to increase the beam intensity of highly charged ion, we tried a technique of supplying cold electrons into the ECR plasma. In this paper, enhancement of the beam intensity is discussed in detail. The bias voltage is applied on the probe to repel cold electrons which flow from a plasma. The output beam current is 130 eμA for Ar 11+ . (J.P.N.)

Centrality of collisions and total disintegration of nuclei

International Nuclear Information System (INIS)

Sulejmanov, M.K.; Abdinov, O.B.; Anoshin, A.I.; Bogdanowicz, J.; Kuznetsov, A.A.

1998-01-01

The interrelation of the processes of total disintegration of nuclei with the process, characterized by the 'centrality' of collisions and a minimum flow of energy of secondary particles emitted at a zero angle in pC, dC, 4 HeC and 12 CC interactions, is investigated at 4.2 A · GeV/c. The events with total disintegration of nuclei are characterized by a high degree 'centrality' of collisions and similar to the events having a minimum flow of energy of particles emitted at a zero angle

Impact of maintenance of floodplains of the Vistula River on high water levels on the section from Włocławek to Toruń

Directory of Open Access Journals (Sweden)

Dariusz Gąsiorowski

2013-09-01

Full Text Available This article describes the methodology of hydraulic calculations to estimate the water levels in open channels for steady gradually varied flow. The presented method has been used to analyse the water level on the Vistula River from Włocławek cross-section to Toruń cross-section. The HEC-RAS modelling system has been used for parameterization of the river channel and floodplains, as well as for flow simulation. The results obtained have been the basis for assessing the impact of maintenance of floodplains on water level during maximum discharges.

Numerical Model Study of the Tuscarawas River below Dover Dam, Ohio

Science.gov (United States)

2009-09-01

chl.erdc.usace.army.mil/sms). Cross-sections from a ERDC/CHL TR-09-17 7 HEC - RAS model provided by the district, along with aerial photographs for proper alignment...ER D C/ CH L TR -0 9 -1 7 Numerical Model Study of the Tuscarawas River below Dover Dam, Ohio Richard L. Stockstill and Jane M. Vaughan...September 2009 C oa st al a n d H yd ra u lic s La b or at or y Approved for public release; distribution is unlimited. ERDC/CHL TR-09

Executive Summary High-Yield Scenario Workshop Series Report

Energy Technology Data Exchange (ETDEWEB)

Leslie Park Ovard; Thomas H. Ulrich; David J. Muth Jr.; J. Richard Hess; Steven Thomas; Bryce Stokes

2009-12-01

To get a collective sense of the impact of research and development (R&D) on biomass resource availability, and to determine the feasibility that yields higher than baseline assumptions used for past assessments could be achieved to support U.S. energy independence, an alternate “High-Yield Scenario” (HYS) concept was presented to industry experts at a series of workshops held in December 2009. The workshops explored future production of corn/agricultural crop residues, herbaceous energy crops (HECs), and woody energy crops (WECs). This executive summary reports the findings of that workshop.

Applicant Perspectives on the Otolaryngology Residency Application Process

Science.gov (United States)

2017-09-09

ndorsing, Suggestion No.(%) (n=98) Establish a hard cap on the number of applications 43 (43.8) altov:ed per applicant Increase information and...Applicants are overall amenable to a hard cap on applications • Applicants are interested in being part of the solution to the problem References...better the chances of match·ng. Alch Otoo1yngo/ Head~:< Surg_ 2008: 4 34(10)·1038. 3. Christophel JJ. Levine PA Too much of .a good thing . lAMA

Applicant Perspectives on the Otolaryngology Residency Application Process.

Science.gov (United States)

Ward, Matthew; Pingree, Christian; Laury, Adrienne M; Bowe, Sarah N

2017-08-01

It has been nearly 25 years since medical students were queried regarding their perspectives on otolaryngology-head and neck surgery (OHNS) residency selection. Understanding this viewpoint is critical to improving the current application process. To evaluate the perceptions of 2016 OHNS residency applicants regarding the application process and offer suggestions for reform. In this cross-sectional study of anonymous online survey data, a 14-question survey was designed based on resources obtained from a computerized PubMed, Ovid, and GoogleScholar database search of the English language from January 1, 1990, through December 31, 2015, was conducted using the following search terms: (medical student OR applicant) AND (application OR match) AND otolaryngology. The survey was administered to 2016 OHNS residency applicants to examine 4 primary areas: current attitudes toward the match, effect of the new Otolaryngology Program Directors Organization personal statement mandate, sources of advice and information, and suggestions for improvement. In January 2016, an email was sent to 100 program directors asking them to distribute the survey to current OHNS applicants at their institution. One follow-up reminder email was sent in February 2016. A link to the survey was posted on the Otomatch.com homepage on January 28, 2016, with the last response received on March 28, 2016. Survey responses regarding the residency application process. A total of 150 of 370 residency applicants (40.5%) responded to the survey. Of these, 125 respondents (90.6%) noted applying to programs in which they had no specific interest simply to improve their chances of matching. Applicants intended to apply to more programs than they actually did (63.6 vs 60.8; r = 0.19; 95% CI, -0.03 to 0.40). Program directors advised fewer applications than other sources; however, 58 respondents (38.7%) did not receive advice from a program director. A total of 121 respondents (80.7%) found online program

Application architecture for .NET designing applications and services

CERN Document Server

Microsoft. Redmond

2003-01-01

Get expert architectural and design-level guidance for building distributed solutions with the Microsoft® .NET Framework-learning how to synthesize your knowledge of application development, servers, and infrastructure and business requirements. This guide assumes you are familiar with .NET component development and the basic principles of a layered distributed application design. It examines architectural issues and solution design for a range of project stakeholders-whether you build and design applications and services, recommend appropriate technologies and products for applications and s

Efficient production of platelets from mouse embryonic stem cells by enforced expression of Gata2 in late hemogenic endothelial cells

Energy Technology Data Exchange (ETDEWEB)

Kawaguchi, Manami [Stem Cell Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506 (Japan); Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510 (Japan); Kitajima, Kenji [Stem Cell Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506 (Japan); Kanokoda, Mai [Stem Cell Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506 (Japan); Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510 (Japan); Suzuki, Hidenori [Division of Morphological and Biomolecular Research, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602 (Japan); Miyashita, Kazuya; Nakajima, Marino [Stem Cell Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506 (Japan); Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510 (Japan); Nuriya, Hideko [Core Technology and Research Center, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506 (Japan); Kasahara, Kohji [Laboratory of Biomembrane, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506 (Japan); Hara, Takahiko, E-mail: hara-tk@igakuken.or.jp [Stem Cell Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506 (Japan); Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510 (Japan)

2016-06-03

Platelets are essential for blood circulation and coagulation. Previous study indicated that overexpression of Gata2 in differentiated mouse embryonic stem cells (ESCs) resulted in robust induction of megakaryocytes (Mks). To evaluate platelet production capacity of the Gata2-induced ESC-derived Mks, we generated iGata2-ESC line carrying the doxycycline-inducible Gata2 expression cassette. When doxycycline was added to day 5 hemogenic endothelial cells in the in vitro differentiation culture of iGata2-ESCs, c-Kit{sup −}Tie2{sup −}CD41{sup +} Mks were predominantly generated. These iGata2-ESC-derived Mks efficiently produced CD41{sup +}CD42b{sup +}CD61{sup +} platelets and adhered to fibrinogen-coated glass coverslips in response to thrombin stimulation. Transmission electron microscopy analysis demonstrated that the iGata2-ESC-derived platelets were discoid-shaped with α-granules and an open canalicular system, but were larger than peripheral blood platelets in size. These results demonstrated that an enforced expression of Gata2 in late HECs of differentiated ESCs efficiently promotes megakaryopoiesis followed by platelet production. This study provides valuable information for ex vivo platelet production from human pluripotent stem cells in future. -- Highlights: •Megakaryocytes are efficiently induced by Gata2 from ESC-derived day 5 HECs. •Gata2-induced ESC-derived megakaryocytes are c-Kit{sup −}Tie2{sup −}CD41{sup +}. •Gata2-induced ESC-derived megakaryocytes produce larger discoid-shaped platelets. •Gata2-induced ESC-derived platelets bind fibrinogen upon thrombin stimulation.

Efficient production of platelets from mouse embryonic stem cells by enforced expression of Gata2 in late hemogenic endothelial cells

International Nuclear Information System (INIS)

Kawaguchi, Manami; Kitajima, Kenji; Kanokoda, Mai; Suzuki, Hidenori; Miyashita, Kazuya; Nakajima, Marino; Nuriya, Hideko; Kasahara, Kohji; Hara, Takahiko

2016-01-01

Platelets are essential for blood circulation and coagulation. Previous study indicated that overexpression of Gata2 in differentiated mouse embryonic stem cells (ESCs) resulted in robust induction of megakaryocytes (Mks). To evaluate platelet production capacity of the Gata2-induced ESC-derived Mks, we generated iGata2-ESC line carrying the doxycycline-inducible Gata2 expression cassette. When doxycycline was added to day 5 hemogenic endothelial cells in the in vitro differentiation culture of iGata2-ESCs, c-Kit − Tie2 − CD41 + Mks were predominantly generated. These iGata2-ESC-derived Mks efficiently produced CD41 + CD42b + CD61 + platelets and adhered to fibrinogen-coated glass coverslips in response to thrombin stimulation. Transmission electron microscopy analysis demonstrated that the iGata2-ESC-derived platelets were discoid-shaped with α-granules and an open canalicular system, but were larger than peripheral blood platelets in size. These results demonstrated that an enforced expression of Gata2 in late HECs of differentiated ESCs efficiently promotes megakaryopoiesis followed by platelet production. This study provides valuable information for ex vivo platelet production from human pluripotent stem cells in future. -- Highlights: •Megakaryocytes are efficiently induced by Gata2 from ESC-derived day 5 HECs. •Gata2-induced ESC-derived megakaryocytes are c-Kit − Tie2 − CD41 + . •Gata2-induced ESC-derived megakaryocytes produce larger discoid-shaped platelets. •Gata2-induced ESC-derived platelets bind fibrinogen upon thrombin stimulation.

Analysis of Runoff due to The Change in Land Use at The Watershed of Upstream Ciliwung

Directory of Open Access Journals (Sweden)

Dwi Indriastuti

2016-01-01

Full Text Available Climate change has triggered extreme climate such as rising temperature, high rainfall intensity, rising sea water level, drought, and others (Thuc, 2014. Challenges of sustainable development are increases in various disasters, climate change and global crisis such as land use change, soil quality degradation, limited water and mineral, environmental pollution, and decreasing in biodiversity. The cause of flooding in Jakarta is due to the overflow of Ciliwung River. The changes of land use greatly affect Ciliwung River flow. Land degradation in upstream of Ciliwung watershed (Puncak area has triggered new problem, annual flooding, especially in downstream area. The change of surface which cannot accommodate water, increasing runoff, moreover, the change of land condition which easily saturated, greatly affected the runoff conditions in Ciliwung watershed. This research using HEC-HMS software in order to know how the land uses changes and rainfall intensity affected the runoff. By using land use maps in 2000, 2005, 2010, and rainfall data in 5 (five rainfall station near location from 1996 to 2013, it can be known how the runoff changes. Parameter calibration is done with measured discharge in Katulampa weir for each occurrence. The parameter value used in simulation later is the real value approach. Simulation by HEC HMS using CN of Spatial Planning in Ciliwung upstream area and rainfall 25 years return period gives that the highest discharge is 226.25 m3/second and water level reaches to 317 cm. If included into the alert in Katulampa weir, then the condition faces to Alert 1 for during ±6 hours.

[Effect of concomitant use of dental drug on the properties of recombinant human basic fibroblast growth factor formulation for periodontal disease].

Science.gov (United States)

Sato, Yasuhiko; Oba, Takuma; Danjo, Kazumi

2013-01-01

We have discussed the essential property for periodontal disease medication using protein, such as recombinant human basic fibroblast growth factor (rhbFGF). In our previous study, the criteria of thickener for the medication, viscosity, flowability etc., were set. The aim of this study was to evaluate the physical and chemical effect of concomitant use of general dental drug or device on thickener properties for the clinical use of viscous rhbFGF formulation. Viscous formulation was prepared with six cellulose derivatives, two types hydroxy propyl cellulose (HPC), three types hydroxy ethyl cellulose (HEC) and methyl cellulose (MC). Antibiotic ointment, local anesthetic, bone graft substitute, agent for gargle and mouthwashes, were chosen as general dental drug and device. These drugs and device were mixed with the viscous formulations and the change of viscosity and flowability, the remaining ratio of rhbFGF were evaluated. When the various thickener solutions were mixed with the liquid drugs, viscosity and flowability did not changed much. However, in the case of MC solution, viscous property declined greatly when MC solution was mixed with cationic surfactant for gargle. The flowabilities of thickener solutions were declined with insoluble bone graft. The stabilities of rhbFGF in thickener solutions were no problem for 24 hours even in the case of mixing with dental drug or device. Our findings suggested that the viscous rhbFGF formulations prepared in this research were not substantially affected by the concomitant use of dental drug or device, especially the formulation with HPC or HEC was useful.

Comparing Web Applications with Desktop Applications: An Empirical Study

DEFF Research Database (Denmark)

Pop, Paul

2002-01-01

In recent years, many desktop applications have been ported to the world wide web in order to reduce (multiplatform) development, distribution and maintenance costs. However, there is little data concerning the usability of web applications, and the impact of their usability on the total cost...... of developing and using such applications. In this paper we present a comparison of web and desktop applications from the usability point of view. The comparison is based on an empirical study that investigates the performance of a group of users on two calendaring applications: Yahoo!Calendar and Microsoft...... Calendar. The study shows that in the case of web applications the performance of the users is significantly reduced, mainly because of the restricted interaction mechanisms provided by current web browsers....

Comprensión Lectora vs Competencia Lectora: qué son y qué relación existe entre ellas

OpenAIRE

Jiménez Pérez, Elena

2013-01-01

La comprensión lectora es la capacidad de un individuo de captar lo más objetivamente posible lo que un autor ha querido transmitir a través de un texto escrito. Por lo tanto, la comprensión lectora (Reading Comprehension) es un concepto abarcado por otro más amplio que es la competencia lectora (Reading Literacy). La competencia lectora es la habilidad de un ser humano de usar su comprensión lectora de forma útil en la sociedad que le rodea. De esta forma, la comprensión lectora es el hec...

Training Program in the Molecular Basis of Breast Cancer Research

Science.gov (United States)

2000-08-01

BRCA1 protein and the product was purified by electrophoresis on a 15% polyacryl - interact with the importin-a subunit of the nuclear transport signal...40 mM potassium phos- the 2.0-kb DNA fragment containing the complete ORF of scHEC] was inserted phate [pH 6.5] containing 0.5 M MgC12 and 4...with a mM potassium HEPES [pH 7.7], 0.1 M KCI, 10% glycerol, 2 mM MgC12, 5 mM number of proteins important for GV/M progression and chro- EGTA), 0.5 ml

High-Energy Corona for destruction of volatile organic contaminants in process off-gases

International Nuclear Information System (INIS)

Virden, J.W.; Heath, W.O.; Goheen, S.C.; Miller, M.C.; Mong, G.M.; Richardson, R.L.

1992-08-01

A small (2 scfm) High-Energy Corona (HEC) reactor was developed to produce a non-equilibrium plasma in a concentric-cylinder geometry. A volume-filling plasma was produced in a packed bed, and initial tests have demonstrated the ability to destroy up to 1500 ppM trichloroethylene at a flow rate of 1.4 scfm, with greater than 99% destruction observed. Destruction efficiency is examined as a function of inlet TCE concentration, bed height (residence time) and applied voltage. Hydrochloric acid appears to be the primary chlorinated byproduct, and can be removed by conventional wet or dry scrubbing

Cold electronics for the liquid argon hadronic end-cap calorimeter of ATLAS

International Nuclear Information System (INIS)

Ban, J.; Brettel, H.; Cwienk, W.D.; Fent, J.; Kurchaninov, L.; Ladygin, E.; Oberlack, H.; Schacht, P.; Stenzel, H.; Strizenec, P.

2006-01-01

This paper describes the on-detector electronics of the ATLAS hadronic end-cap calorimeter (HEC). The electronics is operated in liquid argon; therefore attention is paid to its performance at low temperatures. The core of the electronics are Gallium Arsenide (GaAs) preamplifiers. We present design, layout and results of various tests of the preamplifier chips and summing boards. The calibration and signal cables have been studied under laboratory conditions and the signal distortion is modeled. All parts of the electronics have been produced, tested and assembled on the calorimeter modules. The summary of the commissioning tests is presented

Las redes sociales en la gestión de los recursos naturales : ¿qué hay que aprender de una perspectiva estructural?

OpenAIRE

Bodin, Örjan; Crona, Beatrice; Ernstson, Henrik

2017-01-01

Las redes sociales entre actores y grupos de interés están recibiendo cada vez más atención en los estudios sobre la gestión de los recursos naturales, especialmente en los que se refieren a la gestión adaptativa basada en diferentes formas de participación y cogestión. Las redes sociales se han concebido principalmente como recursos que habilitan la colaboración y la coordinación entre diferentes actores. Aquí, continuamos la discusión iniciada por Newman y Dale (2005), que destacaron el hec...

Shannon entropy: A study of confined hydrogenic-like atoms

Science.gov (United States)

Nascimento, Wallas S.; Prudente, Frederico V.

2018-01-01

The Shannon entropy in the atomic, molecular and chemical physics context is presented by using as test cases the hydrogenic-like atoms Hc, Hec+ and Lic2 + confined by an impenetrable spherical box. Novel expressions for entropic uncertainty relation and Shannon entropies Sr and Sp are proposed to ensure their physical dimensionless characteristic. The electronic ground state energy and the quantities Sr,Sp and St are calculated for the hydrogenic-like atoms to different confinement radii by using a variational method. The global behavior of these quantities and different conjectures are analyzed. The results are compared, when available, with those previously published.

Hydrological modelling in sandstone rocks watershed

Science.gov (United States)

Ponížilová, Iva; Unucka, Jan

2015-04-01

The contribution is focused on the modelling of surface and subsurface runoff in the Ploučnice basin. The used rainfall-runoff model is HEC-HMS comprising of the method of SCS CN curves and a recession method. The geological subsurface consisting of sandstone is characterised by reduced surface runoff and, on the contrary, it contributes to subsurface runoff. The aim of this paper is comparison of the rate of influence of sandstone on reducing surface runoff. The recession method for subsurface runoff was used to determine the subsurface runoff. The HEC-HMS model allows semi- and fully distributed approaches to schematisation of the watershed and rainfall situations. To determine the volume of runoff the method of SCS CN curves is used, which results depend on hydrological conditions of the soils. The rainfall-runoff model assuming selection of so-called methods of event of the SCS-CN type is used to determine the hydrograph and peak flow rate based on simulation of surface runoff in precipitation exceeding the infiltration capacity of the soil. The recession method is used to solve the baseflow (subsurface) runoff. The method is based on the separation of hydrograph to direct runoff and subsurface or baseflow runoff. The study area for the simulation of runoff using the method of SCS CN curves to determine the hydrological transformation is the Ploučnice basin. The Ploučnice is a hydrologically significant river in the northern part of the Czech Republic, it is a right tributary of the Elbe river with a total basin area of 1.194 km2. The average value of CN curves for the Ploučnice basin is 72. The geological structure of the Ploučnice basin is predominantly formed by Mesozoic sandstone. Despite significant initial loss of rainfall the basin response to the causal rainfall was demonstrated by a rapid rise of the surface runoff from the watershed and reached culmination flow. Basically, only surface runoff occures in the catchment during the initial phase of

Sele coastal plain flood risk due to wave storm and river flow interaction

Science.gov (United States)

Benassai, Guido; Aucelli, Pietro; Di Paola, Gianluigi; Della Morte, Renata; Cozzolino, Luca; Rizzo, Angela

2016-04-01

Wind waves, elevated water levels and river discharge can cause flooding in low-lying coastal areas, where the water level is the interaction between wave storm elevated water levels and river flow interaction. The factors driving the potential flood risk include weather conditions, river water stage and storm surge. These data are required to obtain inputs to run the hydrological model used to evaluate the water surface level during ordinary and extreme events regarding both the fluvial overflow and storm surge at the river mouth. In this paper we studied the interaction between the sea level variation and the river hydraulics in order to assess the location of the river floods in the Sele coastal plain. The wave data were acquired from the wave buoy of Ponza, while the water level data needed to assess the sea level variation were recorded by the tide gauge of Salerno. The water stages, river discharges and rating curves for Sele river were provided by Italian Hydrographic Service (Servizio Idrografico e Mareografico Nazionale, SIMN).We used the dataset of Albanella station (40°29'34.30"N, 15°00'44.30"E), located around 7 km from the river mouth. The extreme river discharges were evaluated through the Weibull equation, which were associated with their return period (TR). The steady state river water levels were evaluated through HEC-RAS 4.0 model, developed by Hydrologic Engineering Center (HEC) of the United States Army Corps of Engineers Hydrologic Engineering Center (USACE,2006). It is a well-known 1D model that computes water surface elevation (WSE) and velocity at discrete cross-sections by solving continuity, energy and flow resistance (e.g., Manning) equation. Data requirements for HEC-RAS include topographic information in the form of a series of cross-sections, friction parameter in the form of Manning's n values across each cross-section, and flow data including flow rates, flow change locations, and boundary conditions. For a steady state sub

Language Modelling for Collaborative Filtering: Application to Job Applicant Matching

OpenAIRE

Schmitt , Thomas; Gonard , François; Caillou , Philippe; Sebag , Michèle

2017-01-01

International audience; This paper addresses a collaborative retrieval problem , the recommendation of job ads to applicants. Specifically, two proprietary databases are considered. The first one focuses on the context of unskilled low-paid jobs/applicants; the second one focuses on highly qualified jobs/applicants. Each database includes the job ads and applicant resumes together with the collaborative filtering data recording the applicant clicks on job ads. The proposed approach, called LA...

Modification of doping front migration in electrochemical devices and application to organic electronics

International Nuclear Information System (INIS)

Nolte, Marius; Wan Xianglong; Kopp, Olga; Hermes, Ina; Panz, Jan; Rahmanian, Afsaneh; Knoll, Meinhard

2011-01-01

Research highlights: → In this paper we demonstrate several ways of tuning the doping front migration process in polymer electronic multilayer structures for the first time. By altering the migration layer thickness the migration velocity may be controlled and it is possible to switch between migration mechanisms. The mechanism of delamination produces rapid jumps in migration velocity, while the addition of 2-hydroxyethylcellulose (HEC) can inhibit this effect. In case of vapor activation the migration velocity may be influenced by the relative humidity or by varying the concentration of hygroscopic salts added to the migration layer. The migration mechanisms can be explained in terms of diffusion, capillary transport, and delamination. Tuning the migration process may be used to construct polymer electronic structures such as enhancement and depletion type pseudo transistors and electrical switches (ON-OFF and OFF-ON) with an improved switching time of several minutes. The doping front width is determined by microscopic optical absorption spectroscopy and can be controlled by the concentration of the doping solution. In case of low concentrations the electrochromic effect of the double front is observed. - Abstract: We demonstrate several methods of modifying the doping front migration process in multilayer structures, enabling control of migration velocity and switching between different migration mechanisms. Sharp jumps in migration velocity may be induced using a delamination effect. The influence of migration layer thickness and composition is examined. Migration velocity may also be influenced by exposing the system to a defined relative humidity or by varying the concentration of a hygroscopic salt in the migration layer. The migration mechanisms can be explained in terms of diffusion, capillary transport, and delamination. By tailoring the migration process a variety of polymer electronic structures such as pseudo transistors (enhancement and depletion

THE DIFFERENCE BETWEEN DEVELOPING SINGLE PAGE APPLICATION AND TRADITIONAL WEB APPLICATION BASED ON MECHATRONICS ROBOT LABORATORY ONAFT APPLICATION

Directory of Open Access Journals (Sweden)

V. Solovei

2018-04-01

Full Text Available Today most of desktop and mobile applications have analogues in the form of web-based applications.  With evolution of development technologies and web technologies web application increased in functionality to desktop applications. The Web application consists of two parts of the client part and the server part. The client part is responsible for providing the user with visual information through the browser. The server part is responsible for processing and storing data.MPA appeared simultaneously with the Internet. Multiple-page applications work in a "traditional" way. Every change eg. display the data or submit data back to the server. With the advent of AJAX, MPA learned to load not the whole page, but only a part of it, which eventually led to the appearance of the SPA. SPA is the principle of development when only one page is transferred to the client part, and the content is downloaded only to a certain part of the page, without rebooting it, which allows to speed up the application and simplify the user experience of using the application to the level of desktop applications.Based on the SPA, the Mechatronics Robot Laboratory ONAFT application was designed to automate the management process. The application implements the client-server architecture. The server part consists of a RESTful API, which allows you to get unified access to the application functionality, and a database for storing information. Since the client part is a spa, this allows you to reduce the load on the connection to the server and improve the user experience

29 CFR 2704.202 - Contents of application-where the applicant has prevailed.

Science.gov (United States)

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Contents of application-where the applicant has prevailed... Information Required From Applicants § 2704.202 Contents of application—where the applicant has prevailed. (a) An application for an award under § 2704.105(a) shall show that the applicant has prevailed in a...

Soils Activity Mobility Study: Methodology and Application

Energy Technology Data Exchange (ETDEWEB)

None, None

2014-09-29

This report presents a three-level approach for estimation of sediment transport to provide an assessment of potential erosion risk for sites at the Nevada National Security Site (NNSS) that are posted for radiological purposes and where migration is suspected or known to occur due to storm runoff. Based on the assessed risk, the appropriate level of effort can be determined for analysis of radiological surveys, field experiments to quantify erosion and transport rates, and long-term monitoring. The method is demonstrated at contaminated sites, including Plutonium Valley, Shasta, Smoky, and T-1. The Pacific Southwest Interagency Committee (PSIAC) procedure is selected as the Level 1 analysis tool. The PSIAC method provides an estimation of the total annual sediment yield based on factors derived from the climatic and physical characteristics of a watershed. If the results indicate low risk, then further analysis is not warranted. If the Level 1 analysis indicates high risk or is deemed uncertain, a Level 2 analysis using the Modified Universal Soil Loss Equation (MUSLE) is proposed. In addition, if a sediment yield for a storm event rather than an annual sediment yield is needed, then the proposed Level 2 analysis should be performed. MUSLE only provides sheet and rill erosion estimates. The U.S. Army Corps of Engineers Hydrologic Engineering Center-Hydrologic Modeling System (HEC-HMS) provides storm peak runoff rate and storm volumes, the inputs necessary for MUSLE. Channel Sediment Transport (CHAN-SED) I and II models are proposed for estimating sediment deposition or erosion in a channel reach from a storm event. These models require storm hydrograph associated sediment concentration and bed load particle size distribution data. When the Level 2 analysis indicates high risk for sediment yield and associated contaminant migration or when there is high uncertainty in the Level 2 results, the sites can be further evaluated with a Level 3 analysis using more complex

Java Application Shell: A Framework for Piecing Together Java Applications

Science.gov (United States)

Miller, Philip; Powers, Edward I. (Technical Monitor)

2001-01-01

This session describes the architecture of Java Application Shell (JAS), a Swing-based framework for developing interactive Java applications. Java Application Shell is being developed by Commerce One, Inc. for NASA Goddard Space Flight Center Code 588. The purpose of JAS is to provide a framework for the development of Java applications, providing features that enable the development process to be more efficient, consistent and flexible. Fundamentally, JAS is based upon an architecture where an application is considered a collection of 'plugins'. In turn, a plug-in is a collection of Swing actions defined using XML and packaged in a jar file. Plug-ins may be local to the host platform or remotely-accessible through HTTP. Local and remote plugins are automatically discovered by JAS upon application startup; plugins may also be loaded dynamically without having to re-start the application. Using Extensible Markup Language (XML) to define actions, as opposed to hardcoding them in application logic, allows easier customization of application-specific operations by separating application logic from presentation. Through XML, a developer defines an action that may appear on any number of menus, toolbars, and buttons. Actions maintain and propagate enable/disable states and specify icons, tool-tips, titles, etc. Furthermore, JAS allows actions to be implemented using various scripting languages through the use of IBM's Bean Scripting Framework. Scripted action implementation is seamless to the end-user. In addition to action implementation, scripts may be used for application and unit-level testing. In the case of application-level testing, JAS has hooks to assist a script in simulating end-user input. JAS also provides property and user preference management, JavaHelp, Undo/Redo, Multi-Document Interface, Single-Document Interface, printing, and logging. Finally, Jini technology has also been included into the framework by means of a Jini services browser and the

Creation of web applications by Rich Internet Application Adobe Flex

OpenAIRE

PEKA, Karel

2011-01-01

Bachelor work focuses on explaining the functions and development of interactive applications in Adobe Flex RIA also compared to similar web technologies such as AJAX, Microsoft Silverlight or Adobe Flash. Explain the difference between "ordinary" sites and Rich Internet Application (RIA) and the difference shows a series of demonstration examples were processed in Adobe Flash Builder (environment for building Flex applications). Also will be created large-scale application for comprehensive ...

Engineering applications using CAD based application programming interface

Directory of Open Access Journals (Sweden)

Tzotzis Anastasios

2017-01-01

Full Text Available Automating the design process of a product or a system can provide engineers and designers with many benefits. As such, repeatable tasks that are time consuming can be handled automatically and with minimal human attention. This is achieved by using the API (Application Programmable Interface of CAD systems in order to create macros or even develop software applications. The present paper deals with an application that has been developed with the API of a general purposes CAD system. This application automates the design process of a standard pneumatic double acting cylinder based on the appropriate inserted parameters (ISO 15552.The design process begins with the creation of a series of components developed as solids, and extends to the extraction of basic attributes and properties from the complete mechanical assembly. Finally, the assembled models and the extracted data can be used to further study the design of the pneumatic double acting cylinder. It is expected in the future to expand the features of the presented application in order to automate the design process of other related mechanical systems.

Thermo-economic assessment of externally fired micro-gas turbine fired by natural gas and biomass: Applications in Italy

International Nuclear Information System (INIS)

Pantaleo, A.M.; Camporeale, S.M.; Shah, N.

2013-01-01

Highlights: • A thermo-economic analysis of natural gas/biomass fired microturbine is proposed. • Energy efficiency, capex, opex and electricity revenues trade-offs are assessed. • The optimal biomass energy input is 70% of total CHP consumption. • Industrial/tertiary heat demand and baseload/heat driven operation is assessed. • The main barriers of small scale CHP systems in Italy are overviewed. - Abstract: This paper proposes a thermo-economic assessment of small scale (100 kWe) combined heat and power (CHP) plants fired by natural gas and solid biomass. The focus is on dual fuel gas turbine cycle, where compressed air is heated in a high temperature heat exchanger (HTHE) using the hot gases produced in a biomass furnace, before entering the gas combustion chamber. The hot air expands in the turbine and then feeds the internal pre-heater recuperator, Various biomass/natural gas energy input ratios are modeled, ranging from 100% natural gas to 100% biomass. The research assesses the trade-offs between: (i) lower energy conversion efficiency and higher investment cost of high biomass input rate and (ii) higher primary energy savings and revenues from bio-electricity feed-in tariff in case of high biomass input rate. The influence of fuel mix and biomass furnace temperature on energy conversion efficiencies, primary energy savings and profitability of investments is assessed. The scenarios of industrial vs. tertiary heat demand and baseload vs. heat driven plant operation are also compared. On the basis of the incentives available in Italy for biomass electricity and for high efficiency cogeneration (HEC), the maximum investment profitability is achieved for 70% input biomass percentage. The main barriers of these embedded cogeneration systems in Italy are also discussed

PSA applications

International Nuclear Information System (INIS)

Dubreuil Chambardel, A.

1996-01-01

The IAEA now defines three types of PSA applications: Validation of design and of operation procedures; optimization of plant operation; and regulatory applications. The applications of PSA are manifold: only a few are dealt with here (precursor analysis is dealt with in session 3, topic 4). For each of them, we will do the utmost to demonstrate the main difficulties encountered, EDF's viewpoint on the matter, and the points remaining to be solved. In what follows, unless explicitly stated otherwise, we have made every effort to represent the different applications as they are practiced by all concerned in the international community, and to describe the inherent difficulties the international community has encountered with these applications with all objectivity. It goes without saying that the comments below are simply those of the ESF department, and are submitted here for discussion by the experts. 13 refs

PSA applications

Energy Technology Data Exchange (ETDEWEB)

Dubreuil Chambardel, A

1997-12-31

The IAEA now defines three types of PSA applications: Validation of design and of operation procedures; optimization of plant operation; and regulatory applications. The applications of PSA are manifold: only a few are dealt with here (precursor analysis is dealt with in session 3, topic 4). For each of them, we will do the utmost to demonstrate the main difficulties encountered, EDF`s viewpoint on the matter, and the points remaining to be solved. In what follows, unless explicitly stated otherwise, we have made every effort to represent the different applications as they are practiced by all concerned in the international community, and to describe the inherent difficulties the international community has encountered with these applications with all objectivity. It goes without saying that the comments below are simply those of the ESF department, and are submitted here for discussion by the experts. 13 refs.

37 CFR 2.27 - Pending trademark application index; access to applications.

Science.gov (United States)

2010-07-01

... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Pending trademark application... Registration § 2.27 Pending trademark application index; access to applications. (a) An index of pending... particular pending application will be permitted prior to publication under § 2.80 upon written request. (c...

LCA Applications

DEFF Research Database (Denmark)

Owsianiak, Mikołaj; Bjørn, Anders; Laurent, Alexis

2018-01-01

The chapter gives examples of applications of LCA by the central societal actors in government, industry and citizens, and discusses major motivations and challenges for the use of LCA to support science-based decision-making from their respective perspectives. We highlight applications of LCA...... environmental impacts of products and systems and support decisions around production and consumption and highlights factors that prevent its even more widespread application....

The further environmental development of Polyphyto Hydroelectric Project reservoir in Kozani prefecture and its contribution to the life quality improvement

Science.gov (United States)

Saounatsou, Chara; Georgi, Julia

2014-08-01

The Polyphyto Hydroelectric Project was constructed in 1974 and it has been operating since on the Aliakmonas River, Kozani prefecture, by the Greek Public Power Corporation. The construction of the Ilarion Hydroelectric Project, upstream from the Polyphyto Reservoir, has been recently completed and will start operating in the near future. Apart from hydroelectric power production, the Polyphyto reservoir provides flood control to the areas below the Polyphyto dam. It is also used to manage water provision to the city of Thessaloniki and adjacent agricultural plain, providing at the same time cooling water to the Thermo Electric Projects in Ptolemaida. The Polyphyto reservoir has potential for further development as an economic fulcrum to the region in which is located. The Kozani and Servia-Velvendos Municipalities have proceeded to the construction of several touristic, nautical - athletic and fishing projects. In order to promote such developments, while preserving the artificial wetland, flora and fauna of the Polyphyto Reservoir, it is important to reduce the fluctuation of the reservoir elevation which according to its technical characteristics is 21m. The aim of this paper is to propose the combined operation of the two Hydroelectric Project reservoirs to satisfy all the present Polyphyto Hydroelectric Project functions and to reduce the annual fluctuation of the Polyphyto Reservoir. The HEC-5, Version 8 / 1998 computer model was used in our calculations, as developed by the Hydrologic Engineering Center (HEC) of the US Army Corps of Engineers for reservoir operation simulation. Five possible operation scenarios are tested in this paper to show that the present fluctuation of the Polyphyto Reservoir can be reduced, with some limitations, except during dry weather periods.

Integrated hazard assessment of Cirenmaco glacial lake in Zhangzangbo valley, Central Himalayas

Science.gov (United States)

Wang, Weicai; Gao, Yang; Iribarren Anacona, Pablo; Lei, Yanbin; Xiang, Yang; Zhang, Guoqing; Li, Shenghai; Lu, Anxin

2018-04-01

Glacial lake outburst floods (GLOFs) have recently become one of the primary natural hazards in the Himalayas. There is therefore an urgent need to assess GLOF hazards in the region. Cirenmaco, a moraine-dammed lake located in the upstream portion of Zhangzangbo valley, Central Himalayas, has received public attention after its damaging 1981 outburst flood. Here, by combining remote sensing methods, bathymetric survey and 2D hydraulic modeling, we assessed the hazard posed by Cirenmaco in its current status. Inter-annual variation of Cirenmaco lake area indicates a rapid lake expansion from 0.10 ± 0.08 km2 in 1988 to 0.39 ± 0.04 km2 in 2013. Bathymetric survey shows the maximum water depth of the lake in 2012 was 115 ± 2 m and the lake volume was calculated to be 1.8 × 107 m3. Field geomorphic analysis shows that Cirenmaco glacial lake is prone to GLOFs as mass movements and ice and snow avalanches can impact the lake and the melting of the dead ice in the moraine can lower the dam level. HEC-RAS 2D model was then used to simulate moraine dam failure of the Cirenmaco and assess GLOF impacts downstream. Reconstruction of Cirenmaco 1981 GLOF shows that HEC-RAS can produce reasonable flood extent and water depth, thus demonstrate its ability to effectively model complex GLOFs. GLOF modeling results presented can be used as a basis for the implementation of disaster prevention and mitigation measures. As a case study, this work shows how we can integrate different methods to GLOF hazard assessment.

Erosion potential from Missoula floods in the Pasco Basin, Washington

International Nuclear Information System (INIS)

Craig, R.G.; Hanson, J.P.

1985-12-01

Localities within the Pasco Basin preserve evidence of Missoula floods. Deposits are 46% sand-sized, 36% gravel-sized, and 18% finer than sand-sized. Mean thickness is 39 meters. High water marks at Wallula Gap require a discharge of approximately 12.5 Mcms. At Sentinel Gap, the slope-area method shows that the high water marks require a discharge of 34.6 Mcms. Since this discharge greatly exceeds any estimated for Missoula floods, there must have been backwater ponding from Wallula Gap. Projecting the slope of the water surface at the upper end of Wallula Gap to the downstream cross section at Gable Mountain leads to a discharge of 9.5 Mcms at Sentinel Gap. The HEC-6 steady state code and four sediment transport equations were applied. Assuming sand-sized particles, DuBoys function estimated 4 to 9 meters of scour. Yang's equation estimated 3 to 4 meters of scour. These are a minimum. A hydrograph synthesized for the boundaries of the Pasco Basin shows the maxima of the flood would occur after 90 h at Sentinel Gap, and at 114 h at Wallula Gap. The 200 areas will remain inundated for four days and six hours. With a quasi-dynamic sediment transport computation, HEC-6 scour estimates range from 0.61 meters to 0.915 meters. This is a minimum amount and erosion is highly variable suggesting reworking of sediment. The Meyer-Peter Meuller equations show less than 1 meter of net scour in the 200 areas. More extensive erosion was achieved during particular time steps of this analysis suggesting that sediment re-working would occur

Prostaglandin receptor EP3 regulates cell proliferation and migration with impact on survival of endometrial cancer patients.

Science.gov (United States)

Zhu, Junyan; Trillsch, Fabian; Mayr, Doris; Kuhn, Christina; Rahmeh, Martina; Hofmann, Simone; Vogel, Marianne; Mahner, Sven; Jeschke, Udo; von Schönfeldt, Viktoria

2018-01-02

Prostaglandin E2 (PGE2) receptor 3 (EP3) regulates tumor cell proliferation, migration, and invasion in numerous cancers. The role of EP3 as a prognostic biomarker in endometrial cancer remains unclear. The primary aim of this study was to analyze the prognostic significance of EP3 expression in endometrial cancer. We analyzed the EP3 expression of 140 endometrial carcinoma patients by immunohistochemistry. RL95-2 endometrial cancer cell line was chosen from four endometrial cancer cell lines (RL95-2, Ishikawa, HEC-1-A, and HEC-1-B) according to EP3 expression level. Treated with PGE2 and EP3 antagonist, RL95-2 cells were investigated by MTT, BrdU, and wound healing assay for functional assessment of EP3. EP3 staining differed significantly according to WHO tumor grading in both whole cohort (p = 0.01) and the subgroup of endometrioid carcinoma (p = 0.01). Patients with high EP3 expression in their respective tumors had impaired progression-free survival as well as overall survival in both cohorts above. EP3 expression in the overall cohort was identified as an independent prognostic marker for progression-free survival (HR 1.014, 95%CI 1.003-1.024, p = 0.01) when adjusted for age, stage, grading, and recurrence. Treatment with EP3 antagonists induced upregulation of estrogen receptor β and decreased activity of Ras and led to attenuated proliferation and migration of RL95-2 cells. EP3 seems to play a crucial role in endometrial cancer progression. In the context of limited systemic treatment options for endometrial cancer, this explorative analysis identifies EP3 as a potential target for diagnostic workup and therapy.

Perencanaan Sistem Drainase Kebon Agung Kota Surabaya, Jawa Timur

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Made Gita Pitaloka

2017-03-01

Full Text Available Saluran Kebon Agung terletakdi Surabaya bagian selatan di Kecamatan Jambangan dan bermuara di sisi laut Surabaya bagian Timur di Kecamatan Rungkut. Saluran ini memiliki panjang 11 kilometer dan lebar berkisar antara 7 – 12 meter. Pada saluran Kebon Agung terdapat 2 rumah pompa, yaitu Pompa Kutisari dan Pompa Kebon Agung. Rumah pompa ini sudah berfungsi untuk mengurangi banjir di Surabaya, namun masih kurang maksimal, sehingga masih terjadi genangan di beberapa lokasi. Berdasarkan Peta Kawasan Rawan Banjir Kota Surabaya tahun 2014, terdapat kawasan rawan banjir di pemukiman kampung wilayah kecamatan Jambangan akibat luapan sungai Kali Surabaya. Selain itu, menurut BAPPEKO (Badan Perencanaan Pembangunan Kota Surabaya tahun 2015, terjadi pula genangan setinggi 10-40 cm di Kecamatan Wonocolo dan setinggi 10-50 cm di Kecamatan Gununganyar.Perencanaan sistem drainase Kebon Agung dilakukan dengan mengevaluasi kondisi saluran eksisting, kemudian melakukan analisis hidrologi dengan menggunakan program bantu HEC-HMS untuk mendapatkan debit banjir rencana. Sedangkan, analisis hidrolika menggunakan program bantu HEC-RAS dengan dua kali simulasi unsteady flow, yaitu simulasi kondisi saluran eksisting dan hasil perencanaan. Berdasarkan hasil analisis kondisi eksisting diperoleh bahwa genangan air terjadi karena kapasitas kapasitas saluran Kebon Agung saat ini tidak dapat mengalirkan debit banjir rencana, sehingga dibutuhkan perencanaan baru. Lebar saluran primer yang diperlukan berkisar antara 8 sampai 15 meter dengan kedalaman 3 meter, lebar saluran sekunder yang diperlukan berkisar antara 5 sampai 8 meter dengan kedalaman 2,5 meter, dan untuk lebar saluran tersier antara 1,2 sampai 2 meter dengan kedalaman 1 meter sampai 2 meter. Jumlah pompa yang dibutuhkan adalah 5 buah pompa dengan kapasitas 5 m3/detik dan 3 buah pompa dengan kapasitas 1,5 m3/detik.

Comparative clinical effectiveness of various 5-HT3 RA antiemetic regimens on chemotherapy-induced nausea and vomiting associated with hospital and emergency department visits in real world practice.

Science.gov (United States)

Hatoum, Hind T; Lin, Swu-Jane; Buchner, Deborah; Cox, David

2012-05-01

The aim of this study was to compare the risk of chemotherapy-induced nausea and vomiting (CINV) events for various 5-HT(3) RAs in patients who received moderately (MEC) or highly emetogenic chemotherapy (HEC) by evaluating hospital or emergency department (ED) admissions. PharMetrics claims database was used to identify patients diagnosed with breast cancer (BC) who were initiated on cyclophosphamide-based adjuvant chemotherapy or with lung cancer (LC) initiated on carboplatin-based or cisplatin-based chemotherapy between 2005 and 2008. Patients were stratified in two groups: those initiated and maintained on palonosetron versus those treated with any other 5-HT(3) RA regimens in the 6-month post first chemotherapy. Risk for CINV events, identified by ICD-9-CM for nausea, vomiting, and/or dehydration, were estimated using logistic regressions, controlling for age, gender, comorbidity, and total chemotherapy doses or days. Of the 4,868 cyclophosphamide-treated BC, 5,414 carboplatin-treated LC, and 1,692 cisplatin-treated LC identified, there were 1,864 BC (38.5%), 1,806 carboplatin-treated LC (33.4%), and 390 cisplatin-treated LC (23.0%) in the palonosetron-only group. Palonosetron-only group had significantly lower probability of CINV events associated with ED/hospital admissions in all three cohorts (3.5% vs. 6.3% in BC, 9.5% vs. 13.8% in carboplatin-treated LC, and 16.4% vs. 22.6% in cisplatin-treated LC, all at p HEC had significantly lower risk of CINV events associated with hospital/ED admissions if initiated and maintained on palonosetron relative to patients receiving 5-HT(3) RA regimens.

The Impacts of Pelosika and Ameroro Dams in the Flood Control Performance of Konaweha River

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Arif Sidik

2016-09-01

Full Text Available Konaweeha watershed is the largest watershed in Southeast Sulawesi with Konaweeha River as the main river. The main issues in Konaweeha Watershed is floods that occur caused damage to infrastructure and public facilities, lowering agricultural production, and cause fatalities. One of the government's efforts to cope with the flooding problem in Konaweeha Watershed is planning the construction of multi-purpose dams in the upstream of Konaweeha Watershed that is Pelosika Dam and Ameroso Dam. Necessary to study the flood control performance of the two dams. Analyses were performed with hydrologic-hydraulic modeling using HEC-HMS software (Hydrologic Modelling System version 4.0 and HEC-RAS (River Analysis System version 4.1. The design rainfalls that were used as input to the model were 2 year, 5-year, 10-year and 25 year. Scenarios used in this study are: (1 Existing Scenario (2 Pelosika Dam Scenario; (3 Ameroro Dam Scenario; (4 Pelosika and Ameroro Dams Scenario. The results showed the maximum water surface elevation along the downstream of Konaweeha River in Scenario (2 and (4 were almost the same in the 2 and 5 years return period design flood. However, in case of 10 and 25 years return period, the difference of maximum water surface elevation at downstream of Konaweeha River was slightly significant. Furthermore, the damping efficiency of the peak discharge (at Probably Maximum Flood or PMF was found to be 71.70% and 18.18% for the individual Pelosika Dam and Ameroro Dam respectively. Further discussion suggests the development of Pelosika Dam as the higher priority rather than that of the Ameroro Dam.

Floodplain hydrodynamic modelling of the Lower Volta River in Ghana

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Frederick Yaw Logah

2017-12-01

Full Text Available The impacts of dam releases from re-operation scenarios of the Akosombo and Kpong hydropower facilities on downstream communities along the Lower Volta River were examined through hydrodynamic modelling using the HEC-RAS hydraulic model. The model was used to simulate surface water elevation along the river reach for specified discharge hydrographs from proposed re-operation dam release scenarios. The morphology of the river and its flood plains together with cross-sectional profiles at selected river sections were mapped and used in the hydrodynamic modelling. In addition, both suspended and bed-load sediment were sampled and analysed to determine the current sediment load of the river and its potential to carry more sediment. The modelling results indicate that large areas downstream of the dam including its flood plains would be inundated if dam releases came close to or exceeded 2300 m3/s. It is therefore recommended to relocate communities along the banks and in the flood plains of the Lower Volta River when dam releases are to exceed 2300 m3/s. Suspended sediment transport was found to be very low in the Lower Volta River and the predominant soil type in the river banks and bed is sandy soil. Thus, the geomorphology of the river can be expected to change considerably with time, particularly for sustained high releases from the Akosombo and Kpong dams. The results obtained from this study form a basis for assessing future sedimentation problems in the Lower Volta River and for underpinning the development of sediment control and management strategies for river basins in Ghana. Keywords: Geomorphology, HEC-RAS model, Dam release, Floodplain, Lower Volta River, Ghana

Digital Elevation Model Correction for the thalweg values of Obion River system, TN

Science.gov (United States)

Dullo, T. T.; Bhuyian, M. N. M.; Hawkins, S. A.; Kalyanapu, A. J.

2016-12-01

Obion River system is located in North-West Tennessee and discharges into the Mississippi River. To facilitate US Department of Agriculture (USDA) to estimate water availability for agricultural consumption a one-dimensional HEC-RAS model has been proposed. The model incorporates the major tributaries (north and south), main stem of Obion River along with a segment of the Mississippi River. A one-meter spatial resolution Light Detection and Ranging (LiDAR) derived Digital Elevation Model (DEM) was used as the primary source of topographic data. LiDAR provides fine-resolution terrain data over given extent. However, it lacks in accurate representation of river bathymetry due to limited penetration beyond a certain water depth. This reduces the conveyance along river channel as represented by the DEM and affects the hydrodynamic modeling performance. This research focused on proposing a method to overcome this issue and test the qualitative improvement by the proposed method over an existing technique. Therefore, objective of this research is to compare effectiveness of a HEC-RAS based bathymetry optimization method with an existing hydraulic based DEM correction technique (Bhuyian et al., 2014) for Obion River system in Tennessee. Accuracy of hydrodynamic simulations (upon employing bathymetry from respective sources) would be regarded as the indicator of performance. The aforementioned river system includes nine major reaches with a total river length of 310 km. The bathymetry of the river was represented via 315 cross sections equally spaced at about one km. This study targeted to selecting best practice for treating LiDAR based terrain data over complex river system at a sub-watershed scale.

Erosion potential from Missoula floods in the Pasco Basin, Washington

Energy Technology Data Exchange (ETDEWEB)

Craig, R.G.; Hanson, J.P.

1985-12-01

Localities within the Pasco Basin preserve evidence of Missoula floods. Deposits are 46% sand-sized, 36% gravel-sized, and 18% finer than sand-sized. Mean thickness is 39 meters. High water marks at Wallula Gap require a discharge of approximately 12.5 Mcms. At Sentinel Gap, the slope-area method shows that the high water marks require a discharge of 34.6 Mcms. Since this discharge greatly exceeds any estimated for Missoula floods, there must have been backwater ponding from Wallula Gap. Projecting the slope of the water surface at the upper end of Wallula Gap to the downstream cross section at Gable Mountain leads to a discharge of 9.5 Mcms at Sentinel Gap. The HEC-6 steady state code and four sediment transport equations were applied. Assuming sand-sized particles, DuBoys function estimated 4 to 9 meters of scour. Yang's equation estimated 3 to 4 meters of scour. These are a minimum. A hydrograph synthesized for the boundaries of the Pasco Basin shows the maxima of the flood would occur after 90 h at Sentinel Gap, and at 114 h at Wallula Gap. The 200 areas will remain inundated for four days and six hours. With a quasi-dynamic sediment transport computation, HEC-6 scour estimates range from 0.61 meters to 0.915 meters. This is a minimum amount and erosion is highly variable suggesting reworking of sediment. The Meyer-Peter Meuller equations show less than 1 meter of net scour in the 200 areas. More extensive erosion was achieved during particular time steps of this analysis suggesting that sediment re-working would occur.

A study on the tolerance level of farmers toward human-wildlife conflict in the forest buffer zones of Tamil Nadu.

Science.gov (United States)

Senthilkumar, K; Mathialagan, P; Manivannan, C; Jayathangaraj, M G; Gomathinayagam, S

2016-07-01

The aim of this work was to study the tolerance level of farmers toward different human-wildlife conflict (HWC) situations. This study was conducted in 24 villages of nine blocks from Kancheepuram, Coimbatore, Erode, and Krishnagiri districts of Tamil Nadu by personally interviewing 240 farmers affected with four different HWC situations such as human-elephant conflict (HEC), human-wild pig conflict (HPC), human-gaur conflict (HGC), and human-monkey conflict (HMC). A scale developed for this purpose was used to find out the tolerance level of the farmers. In general, the majority (61.70%) of the farmers had medium level of tolerance toward HWC, whereas 25.40% and 12.90% belonged to a high and low category, respectively. The mean tolerance level of the farmer's encountering HMC is low (8.77) among the other three wild animal conflicts. In tackling HWC, the majority (55.00%) of the HEC farmers drove the elephant once it entered into their farmland. In the HPC, more than three-fourths of the respondents drove away the wild pig once they were found in farmlands. With regard to the HMC, a less number of them (1.70%) drove the monkey away if monkeys were spotted in their village. With regard to HGC, 95.00% of the respondents frightened the gaurs if their family members were threatened by gaurs. The present study suggests that that majority of the farmers had medium level of tolerance toward HWC. The tolerance level of the HMC farmers was lower than other three HWC affected farmers. This study emphasizes the need for necessary training to tackle the problem in an effective manner for wild animal conservation.

Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse

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Sun Mianmian

2010-11-01

Full Text Available Abstract Background Several active ingredients proposed as vaginal microbicides have been shown paradoxically to increase susceptibility to infection in mouse genital herpes (HSV-2 vaginal susceptibility models and in clinical trials. In addition, "inactive ingredients" (or excipients used in topical products to formulate and deliver the active ingredient might also cause epithelial toxicities that increase viral susceptibility. However, excipients have not previously been tested in susceptibility models. Methods Excipients commonly used in topical products were formulated in a non-toxic vehicle (the "HEC universal placebo", or other formulations as specified. Twelve hours after exposure to the excipient or a control treatment, mice were challenged with a vaginal dose of HSV-2, and three days later were assessed for infection by vaginal lavage culture to assess susceptibility. Results The following excipients markedly increased susceptibility to HSV-2 after a single exposure: 5% glycerol monolaurate (GML formulated in K-Y® Warming Jelly, 5% GML as a colloidal suspension in phosphate buffered saline, K-Y Warming Jelly alone, and both of its humectant/solvent ingredients (neat propylene glycol and neat PEG-8. For excipients formulated in the HEC vehicle, 30% glycerin significantly increased susceptibility, and a trend toward increased HSV-2 susceptibility was observed after 10% glycerin, and 0.1% disodium EDTA, but not after 0.0186% disodium EDTA. The following excipients did not increase susceptibility: 10% propylene glycol, 0.18%, methylparaben plus 0.02% propylparaben, and 1% benzyl alcohol. Conclusions As reported with other surfactants, the surfactant/emulsifier GML markedly increased susceptibility to HSV-2. Glycerin at 30% significantly increased susceptibility, and, undiluted propylene glycol and PEG-8 greatly increased susceptibility.