WorldWideScience

Sample records for app anterograde transport

  1. Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport

    Directory of Open Access Journals (Sweden)

    Martin Steuble

    2012-06-01

    Endocytosis of amyloid-β precursor protein (APP is thought to represent the major source of substrate for the production of the amyloidogenic Aβ peptide by the β-secretase BACE1. The irreversible nature of proteolytic cleavage implies the existence of an efficient replenishment route for APP from its sites of synthesis to the cell surface. We recently found that APP exits the trans-Golgi network in intimate association with calsyntenin-1, a transmembrane cargo-docking protein for Kinesin-1-mediated vesicular transport. Here we characterized the function of calsyntenin-1 in neuronal APP transport using selective immunoisolation of intracellular trafficking organelles, immunocytochemistry, live-imaging, and RNAi. We found that APP is co-transported with calsyntenin-1 along axons to early endosomes in the central region of growth cones in carriers that exclude the α-secretase ADAM10. Intriguingly, calsyntenin-1/APP organelles contained BACE1, suggesting premature cleavage of APP along its anterograde path. However, we found that APP contained in calsyntenin-1/APP organelles was stable. We further analyzed vesicular trafficking of APP in cultured hippocampal neurons, in which calsyntenin-1 was reduced by RNAi. We found a markedly increased co-localization of APP and ADAM10 in axons and growth cones, along with increased proteolytic processing of APP and Aβ secretion in these neurons. This suggested that the reduced capacity for calsyntenin-1-dependent APP transport resulted in mis-sorting of APP into additional axonal carriers and, therefore, the premature encounter of unprotected APP with its ectodomain proteases. In combination, our results characterize calsyntenin-1/APP organelles as carriers for sheltered anterograde axonal transport of APP.

  2. Nerve-pathways of acupoint Fengch'ih in rat by anterograde transport of HRP

    Institute of Scientific and Technical Information of China (English)

    Gang-Ming Xi; Hua-Qiao Wang; Guo-Hou He; Chao-Feng Huang; Qun-Fang Yuan; Guo-Yao Wei; Hua Li; Wen-Wen Liu; Hua-Yan Fan

    2005-01-01

    AIM: To study the nervous-pathways of Fengchih acupuncture by means of anterograde transport of aqueous solution of horseradish peroxidase (HRP).METHODS: Fifty Wistar rats were randomly divided into 1,2, 3, 4, and 5 d groups, and every group had 10 animals. HRP(30% aqueous solution) was injected into a Fengchih. Serial, transverse or capital, 40 μm sections of the cervical spinal ganglia, cervical and thoracic spinal cord segment and brain were cut on a cryotome. Sections were incubated for HRP histochemistry according to the tetramethylbenzidine (TMB). Part of the sections were counterstained with neutral red. RESULTS: After 1 d of survival times, many labeled cell bodies were found in 1-4 cervical spinal ganglia, anterior horn of 1-4 cervical spinal cord, ventromedial division of facial nucleus, accessory facial nucleus ipsilaterally. With increasing survival times, the intensity of labeled cells were slightly decreased. CONCLUSION: Fengchih may bring into full play its effect by correlation of posterior ear branch of facial nerve and anterior branch of 2-3 cervical nerve with 1-4 cervical the anterior horn of the spinal cord, ventromedial division of facial nucleus, accessory facial nucleus.

  3. Anterograde Amnesia

    Directory of Open Access Journals (Sweden)

    Serap Erdogan

    2010-08-01

    Full Text Available Memory can be divided into two categories (i.e. short term memory and long term memory according to time span. Information at our long term memory that can be remembered with conscious effort are placed in declarative memory. Information that can not be remembered conciously are placed in nondeclarative memory. The definition of anterograde amnesia is inability to generate new memories after the event causing amnesia. Episodic and semantic memories are usually unaffected among patients’ who had such amnesia. Anterograde amnesia could mostly result from head trauma but in some cases the cause could be serebrovascular events, Wernicke-Korsakoff Syndrome, santral nervous system enfections, anoxia or various substances. Medial temporal lobe and medial diencephalon are two brain regions mainly related with this condition. Medial temporal lobe is consisted of hippocampus, amygdala, parahippocampal cortex, perirhinal cortex and entorhinal cortex. Hypothalamus, thalamus, mamillary bodies and several thalamic nucleases compose medial diencephalon. Fornix and rarely serebellum damage may also play role in the development of anterograde amnesia. After the famous H.M case, who had anterograde amnesia after an epileptic surgery operation, hippocampus has been placed in the focus of memory researches. In the literature there are several reports evaluating brain tissues of amnesic patients at postmortem stage. Postmortem histological evaluations consistently revealed hippocampal neuronal loss among these patients’ brain tissues. Benzodiazepines usually cause short term anterograde amnesia. Benzodiazepine receptors are allosteric modulatory sites on gamma-aminobutyric acid-A (GABA-A receptors. GABA-A receptors composed of five subunits and anterograde amnesia emerges by means of alfa 1 subunit. Anterograde amnesia has been suggested to occur by the blocking of long term potentiation in hippocampus and piriform cortex. For the treatment of the anterograde

  4. Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA/2J mouse model of glaucoma

    Directory of Open Access Journals (Sweden)

    Christine M Dengler-Crish

    2014-09-01

    Full Text Available Axonal transport deficits have been reported as an early pathology in several neurodegenerative disorders, including glaucoma. However, the progression and mechanisms of these deficits are poorly understood. Previous work suggests that anterograde transport is affected earlier and to a larger degree than retrograde transport, yet this has never been examined directly in vivo. Using combined anterograde and retrograde tract tracing methods, we examined the time-course of anterograde and retrograde transport deficits in the retinofugal projection in pre-glaucomatous (3 month-old and glaucomatous (9-13 month old DBA/2J mice. DBA/2J-Gpnmb+ mice were used as a control strain and were shown to have similar retinal ganglion cell densities as C57BL/6J control mice—a strain commonly investigated in the field of vision research. Using cholera toxin-B injections into the eye and FluoroGold injections into the superior colliculus (SC, we were able to measure anterograde and retrograde transport in the primary visual projection. In DBA/2J, anterograde transport from the retina to superior colliculus (SC was decreased by 69% in the 9-10 month-old age group, while retrograde transport was only reduced by 23% from levels seen in pre-glaucomatous mice. Despite this minor reduction, retrograde transport remained largely intact in these glaucomatous age groups until 13-months of age. These findings indicate that axonal transport deficits occur in semi-functional axons that are still connected to their brain targets. Structural persistence as determined by presence of estrogen-related receptor beta label in the superficial SC was maintained beyond time-points where reductions in retrograde transport occurred, also supporting that transport deficits may be due to physiological or functional abnormalities as opposed to overt structural loss.

  5. Peri-Golgi vesicles contain retrograde but not anterograde proteins consistent with the cisternal progression model of intra-Golgi transport

    OpenAIRE

    José A Martínez-Menárguez; Prekeris, Rytis; Oorschot, Viola M J; Scheller, Richard; Slot, Jan W.; Geuze, Hans J.; Klumperman, Judith

    2001-01-01

    A cisternal progression mode of intra-Golgi transport requires that Golgi resident proteins recycle by peri-Golgi vesicles, whereas the alternative model of vesicular transport predicts anterograde cargo proteins to be present in such vesicles. We have used quantitative immuno-EM on NRK cells to distinguish peri-Golgi vesicles from other vesicles in the Golgi region. We found significant levels of the Golgi resident enzyme mannosidase II and the transport machinery proteins giantin, KDEL-rece...

  6. A synthetic peptide shows retro- and anterograde neuronal transport before disrupting the chemosensation of plant-pathogenic nematodes.

    Directory of Open Access Journals (Sweden)

    Dong Wang

    Full Text Available Cyst nematodes are a group of plant pathogens each with a defined host range that cause major losses to crops including potato, soybean and sugar beet. The infective mobile stage hatches from dormant eggs and moves a short distance through the soil to plant roots, which it then invades. A novel strategy for control has recently been proposed in which the plant is able to secrete a peptide which disorientates the infective stage and prevents invasion of the pathogen. This study provides indirect evidence to support the mechanism by which one such peptide disrupts chemosensory function in nematodes. The peptide is a disulphide-constrained 7-mer with the amino acid sequence CTTMHPRLC that binds to nicotinic acetylcholine receptors. A fluorescently tagged version of this peptide with both epifluorescent and confocal microscopy was used to demonstrate that retrograde transport occurs from an aqueous environment along bare-ending primary cilia of chemoreceptive sensilla. The peptide is transported to the cell bodies of these neurons and on to a limited number of other neurons to which they connect. It appears to be localised in both neuronal processes and organelles adjacent to nuclei of some neurons suggesting it could be transported through the Golgi apparatus. The peptide takes 2.5 h to reach the neuronal cell bodies. Comparative studies established that similar but less abundant uptake occurs for Caenorhabditis elegans along its well studied dye-filling chemoreceptive neurons. Incubation in peptide solution or root-exudate from transgenic plants that secrete the peptide disrupted normal orientation of infective cyst nematodes to host root diffusate. The peptide probably undergoes transport along the dye-filling non-cholinergic chemoreceptive neurons to their synapses where it is taken up by the interneurons to which they connect. Coordinated responses to chemoreception are disrupted when the sub-set of cholinergic interneurons secrete the peptide

  7. A synthetic peptide shows retro- and anterograde neuronal transport before disrupting the chemosensation of plant-pathogenic nematodes.

    Science.gov (United States)

    Wang, Dong; Jones, Laura M; Urwin, Peter E; Atkinson, Howard J

    2011-01-01

    Cyst nematodes are a group of plant pathogens each with a defined host range that cause major losses to crops including potato, soybean and sugar beet. The infective mobile stage hatches from dormant eggs and moves a short distance through the soil to plant roots, which it then invades. A novel strategy for control has recently been proposed in which the plant is able to secrete a peptide which disorientates the infective stage and prevents invasion of the pathogen. This study provides indirect evidence to support the mechanism by which one such peptide disrupts chemosensory function in nematodes. The peptide is a disulphide-constrained 7-mer with the amino acid sequence CTTMHPRLC that binds to nicotinic acetylcholine receptors. A fluorescently tagged version of this peptide with both epifluorescent and confocal microscopy was used to demonstrate that retrograde transport occurs from an aqueous environment along bare-ending primary cilia of chemoreceptive sensilla. The peptide is transported to the cell bodies of these neurons and on to a limited number of other neurons to which they connect. It appears to be localised in both neuronal processes and organelles adjacent to nuclei of some neurons suggesting it could be transported through the Golgi apparatus. The peptide takes 2.5 h to reach the neuronal cell bodies. Comparative studies established that similar but less abundant uptake occurs for Caenorhabditis elegans along its well studied dye-filling chemoreceptive neurons. Incubation in peptide solution or root-exudate from transgenic plants that secrete the peptide disrupted normal orientation of infective cyst nematodes to host root diffusate. The peptide probably undergoes transport along the dye-filling non-cholinergic chemoreceptive neurons to their synapses where it is taken up by the interneurons to which they connect. Coordinated responses to chemoreception are disrupted when the sub-set of cholinergic interneurons secrete the peptide at synapses that

  8. App Inventor

    CERN Document Server

    Wolber, David; Spertus, Ellen; Looney, Liz

    2011-01-01

    Yes, you can create your own apps for Android phones-and it's easy to do. This extraordinary book introduces App Inventor for Android, a powerful visual tool that lets anyone build apps for Android-based devices. Learn the basics of App Inventor with step-by-step instructions for more than a dozen fun projects, such as creating location-aware apps, data storage, and apps that include decision-making logic. The second half of the book features an Inventor's manual to help you understand the fundamentals of app building and computer science. App Inventor makes an excellent textbook for beginne

  9. p95-APP1 links membrane transport to Rac-mediated reorganization of actin

    DEFF Research Database (Denmark)

    Di Cesare, A; Paris, S; Albertinazzi, C;

    2000-01-01

    Motility requires protrusive activity at the cellular edge, where Rho family members regulate actin dynamics. Here we show that p95-APP1 (ArfGAP-putative, Pix-interacting, paxillin-interacting protein 1), a member of the GIT1/PKL family, is part of a complex that interacts with Rac. Wild-type and...

  10. Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in Hippocampal Neurons

    Directory of Open Access Journals (Sweden)

    Bianca Seifert

    2016-01-01

    Full Text Available The neurotrophin brain derived neurotrophic factor (BDNF is an important growth factor in the CNS. Deficits in transport of this secretory protein could underlie neurodegenerative diseases. Investigation of disease-related changes in BDNF transport might provide insights into the cellular mechanism underlying, for example, Alzheimer’s disease (AD. To analyze the role of BDNF transport in AD, live cell imaging of fluorescently labeled BDNF was performed in hippocampal neurons of different AD model systems. BDNF and APP colocalized with low incidence in vesicular structures. Anterograde as well as retrograde transport of BDNF vesicles was reduced and these effects were mediated by factors released from hippocampal neurons into the extracellular medium. Transport of BDNF was altered at a very early time point after onset of human APP expression or after acute amyloid-beta(1-42 treatment, while the activity-dependent release of BDNF remained unaffected. Taken together, extracellular cleavage products of APP induced rapid changes in anterograde and retrograde transport of BDNF-containing vesicles while release of BDNF was unaffected by transgenic expression of mutated APP. These early transport deficits might lead to permanently impaired brain functions in the adult brain.

  11. Anterograde and Retrograde Amnesia following Bitemporal Infarction

    Directory of Open Access Journals (Sweden)

    A. Schnider

    1994-01-01

    Full Text Available A patient suffered very severe anterograde and retrograde amnesia following infarction of both medial temporal lobes (hippocampus and adjacent cortex and the left inferior temporo-occipital area. The temporal stem and the amygdala were intact; these structures do not appear to be critical for new learning in humans. Extension of the left-sided infarct into the inferior temporo-occipital lobe, an area critically involved in visual processing, appears to be responsible for our patient's loss of remote memories.

  12. Desarrollo de una app de servicios relacionados con los transportes para ciudades inteligentes

    OpenAIRE

    Bouso Otero, Raquel

    2015-01-01

    [CASTELLÀ] Este proyecto se basa en una aplicación de servicios que proporciona información sobre los transportes públicos que hay en una ciudad y que pueda utilizarse en diferentes ciudades. Esta información se obtiene integrando en un esquema único, los datos abiertos que ofrecen las ciudades. [ANGLÈS] This project is based on an application service that provides information on public transport is in a city and can be used in different cities. This information is obtained by integrating ...

  13. Mechanism underlying the anterograde transport of the influenza A virus transmembrane proteins and genome in host cytoplasm%甲型流感病毒蛋白和遗传物质在宿主细胞质内顺向转运过程及其机制

    Institute of Scientific and Technical Information of China (English)

    池晓娟; 王松; 黄一帆; 陈吉龙

    2012-01-01

    流感病毒的蛋白和基因组在宿主细胞内能否正确地转运到相关部位,直接影响到病毒颗粒的形态发生.流感病毒跨膜蛋白(HA、NA和M2)主要通过宿主细胞的运输膜泡实现转运,而宿主细胞的蛋白转运机器参与了这一过程.新合成的流感病毒核糖核蛋白复合物(vRNPs)出核后,通过与活化的Rab 11相结合,聚集于邻近微管组织中心(MTOC)的胞内体.然后以运输小膜泡的形式,沿着MTOC的微管网络向细胞膜方向转运.跨膜蛋白和基因组在细胞质内的转运受一些宿主因子的调控,如ARHGAP21和小G蛋白Cdc42能够调节NA蛋白向细胞膜转运,Rab11协助vRNPs从MTOC向细胞膜转运.文中主要讨论新合成的流感病毒跨膜蛋白和遗传物质在宿主细胞质内的顺向转运(Anterograde transport)过程与调控.%Influenza virus assembly requires the completion of viral protein and vRNP transport to the assembly site at the plasma membrane. Therefore, efficient regulation of intracellular transport of the viral proteins and vRNPs to the surface of the host cell is especially important for virus morphogenesis. Influenza A virus uses the machineries of host cells to transport its own components including ribonucleoproteins (vRNPs) and three transmembrane proteins hemagglutinin (HA), neuraminidase (NA) and matrix 2 protein (M2). It has been shown that newly synthesized vRNPs are associated with active form of Rab 11 and accumulate at recycling endosomes adjacent to the microtubule organizing center (MTOC) following nuclear export. Subsequently, they are transported along the microtubule network toward the plasma membranes in cargo vesicles. The viral transmembrane proteins are translated on the rough endoplasmic reticulum and transported to the virus assembly site at the plasma membrane. It has been found that several host factors such as ARHGAP21 and GTPase Cdc42 are involved in regulation of intracellular trafficking of influenza A virus

  14. A Model of Anterograde Oxygenated Lung Blood Flow in Acardia.

    Science.gov (United States)

    Marinakis, Sotirios; Burki, Marco; Abdel-Sayed, Saad; von Segesser, Ludwig Karl

    2016-01-01

    In extreme situations such as hyperacute rejection of heart transplant or major heart trauma, heart explantation and extracorporeal membrane oxygenation (ECMO) hemodynamic support might be the only means for survival. In our previous model of acardia, pulmonary artery (PA) was clamped and did not receive any anterograde blood flow. A model of anterograde PA perfusion might be necessary to avoid ischemic pulmonary damage in prolonged ECMO in acardia. The aim of this study was to describe the surgical technique and to determine the feasibility of an anterograde lung perfusion in acardia through the anastomosis of the right internal mammary artery (RIMA) to the PA. A venoarterial cardiopulmonary bypass was established in three pigs (72 ± 2.6 kg) by the transjugular insertion to the caval axis of a double-staged cannula with carotid artery return. Heart was excised and ECMO was established as previously reported. Right internal mammary artery was harvested and after measurement of its output (93.3 ± 5.8 ml/min, representing 2.17% ± 0.15% of total pump flow), it was anastomosed to PA. Right internal mammary artery anastomosis to PA is a feasible, safe, and easy to perform maneuver assuring an anterograde lung perfusion in acardia. PMID:27442854

  15. Be smart: Download the app!

    CERN Multimedia

    Katarina Anthony

    2013-01-01

    What’s the closest snack point to the CLIC test facility? How do you get from your current location to SM18? How do you enter the CERN Open Days photo contest? Finding out is simple: there’s an app for that!   The CERN Open Days app is your personal guide to the Laboratory. Developed by expert volunteers from the IT Department, the app provides comprehensive practical information on CERN transport, shops, snack points and toilet facilities along with detailed location information and event timetables. You can also favourite the sites, activities and lectures you plan to see, and tick them off as you go along. More information here.

  16. Connections of the lateral reticular nucleus to the lateral vestibular nucleus in the rat. An anterograde tracing study with Phaseolus vulgaris leucoagglutinin

    NARCIS (Netherlands)

    T.J.H. Ruigrok (Tom); M. Cella (Massimo); J. Voogd

    1995-01-01

    textabstractEfferent projections from the lateral reticular nucleus in the rat were investigated with anterograde transport of Phaseolus vulgaris leucoagglutinin. Besides the well known mossy fibre connections to the cerebellar cortex and collaterals to the cerebellar nuclei, a substantial bilateral

  17. Best Android Apps

    CERN Document Server

    Hendrickson, Mike

    2010-01-01

    You can choose from thousands of apps to make your Android device do just about anything you can think of -- and probably a few things you'd never imagine. There are so many Android apps available, in fact, that it's been difficult to find the best of the bunch -- until now. Best Android Apps leads you beyond the titles in Android Market's "Top Paid" and "Top Free" bins to showcase apps that will truly delight, empower, and entertain you. The authors have tested and handpicked more than 200 apps and games, each listed with a description and details highlighting the app's valuable tips and sp

  18. Google Apps zijn leuk

    NARCIS (Netherlands)

    den Hollander, Franciscus

    2014-01-01

    Het bericht dat de Rijksuniversiteit Groningen overgaat op de mailvoorziening en agenda van Google Apps for Education bracht een golf van publiciteit teweeg. Mediaberichten naar aanleiding van de overgang naar Google Apps.

  19. Google App Inventor

    CERN Document Server

    Roberts, Ralph

    2011-01-01

    This book is written in the Beginner's Guide format that takes the reader through a series of steps to build exciting apps using Google's App Inventor. This book is perfect for people with little or no experience, not just Android developers. No matter your level of experience, you will find plenty of information that you can use to create powerful apps, apps that can be published on Android Market and other places.

  20. Android apps security

    CERN Document Server

    Gunasekera, Sheran

    2012-01-01

    Android Apps Security provides guiding principles for how to best design and develop Android apps with security in mind. It explores concepts that can be used to secure apps and how developers can use and incorporate these security features into their apps. This book will provide developers with the information they need to design useful, high-performing, and secure apps that expose end-users to as little risk as possible.  Overview of Android OS versions, features, architecture and security.  Detailed examination of areas where attacks on applications can take place and what controls should b

  1. Biotinylated dextran amine anterograde tracing of the canine corticospinal tract

    Institute of Scientific and Technical Information of China (English)

    Xiao Han; Guangming Lv; Huiqun Wu; Dafeng Ji; Zhou Sun; Yaofu Li; Lemin Tang

    2012-01-01

    In this study, biotinylated dextran amine (BDA) was microinjected into the left cortical motor area of the canine brain. Fluorescence microscopy results showed that a large amount of BDA-labeled pyramidal cells were visible in the left cortical motor area after injection. In the left medulla oblongata, the BDA-labeled corticospinal tract was evenly distributed, with green fluorescence that had a clear boundary with the surrounding tissue. The BDA-positive corticospinal tract entered into the right lateral funiculus of the spinal cord and descended into the posterior part of the right lateral funiculus, close to the posterior horn, from cervical to sacral segments. There was a small amount of green fluorescence in the sacral segment. The distribution of BDA labeling in the canine central nervous system was consistent with the course of the corticospinal tract. Fluorescence labeling for BDA gradually diminished with time after injection. Our findings indicate that the BDA anterograde tracing technique can be used to visualize the localization and trajectory of the corticospinal tract in the canine central nervous system.

  2. Different mechanisms contributing to savings and anterograde interference are impaired in Parkinson’s disease

    Directory of Open Access Journals (Sweden)

    Li-Ann eLeow

    2013-02-01

    Full Text Available Reinforcement and use-dependent plasticity mechanisms have been proposed to be involved in both savings and anterograde interference in adaptation to a visuomotor rotation (c.f.Huang et al., 2011. In Parkinson’s disease (PD, dopamine dysfunction is known to impair reinforcement mechanisms, and could also affect use-dependent plasticity. Here, we assessed savings and anterograde interference in PD with an A1-B-A2 paradigm in which movement repetition was (i favored by the use of a single target, and (ii manipulated through the amount of initial training. PD patients and controls completed either limited or extended training in A1 where they adapted movement to a 30° counter-clockwise rotation of visual feedback of the movement trajectory, and then adapted to a 30° clockwise rotation in B. After subsequent washout, participants readapted to the first 30° counter-clockwise rotation in A2. Controls showed significant anterograde interference from A1 to B only after extended training, and significant A1-B-A2 savings after both limited and extended training. However, despite similar A1 adaptation to controls, PD patients showed neither anterograde interference nor savings. That extended training was necessary in controls to elicit anterograde interference but not savings suggests that savings and anterograde interference do not result from equal contributions of the same underlying mechanism(s. It is suggested that use-dependent plasticity mechanisms contributes to anterograde interference but not to savings, while reinforcement mechanisms contribute to both. As both savings and anterograde interference were impaired in PD, dopamine dysfunction in PD might impair both reinforcement and use-dependent plasticity mechanisms during adaptation to a visuomotor rotation.

  3. Programming Google App Engine

    CERN Document Server

    Sanderson, Dan

    2010-01-01

    As one of today's cloud computing services, Google App Engine does more than provide access to a large system of servers. It also offers you a simple model for building applications that scale automatically to accommodate millions of users. With Programming Google App Engine, you'll get expert practical guidance that will help you make the best use of this powerful platform. Google engineer Dan Sanderson shows you how to design your applications for scalability, including ways to perform common development tasks using App Engine's APIs and scalable services. You'll learn about App Engine's a

  4. Airport Surface Access and Mobile Apps

    Directory of Open Access Journals (Sweden)

    Luis Martin-Domingo

    2015-02-01

    Full Text Available Purpose: Airport Surface Access faces two main opposite issues: (1 cars, being the main transport mode, contribute to the increasing level of congestion and pollution of cities; and (2 simultaneously, parking fees are one important source of airports commercial revenue, creating a dilemma for airports when facing the problem. Following the recent trend of air passengers travelling with Smartphone (78% in 2013, the purpose of this paper is to monitor the adoption of mobile Applications (Apps by airports and to analyze if the information and functions provided in those Apps can help to overcome the above two issues. Design/methodology/approach: 31 iPhone App of some of the largest European airports were evaluated in the lab using the evaluation model of Destinations Mobile Applications (Scolari and Fernández-Cavia 2014 adapted for for the Airport Surface Access on Airport Apps Findings and Originality/value: The Apps evaluated provided a very limited functionality to help passengers to plan and book their trips to/from the airports on public transports and gave high priority to parking information and services. Originality/value: Although Airport Surface Access has been a widely researched, the originality of this paper is the analysis of airport mobile Apps as a potential tool for airports to deal with the surface airport access problems.Access, Airports, Mobile Internet, Commercial Revenues

  5. Apps for Ancient Civilizations

    Science.gov (United States)

    Thompson, Stephanie

    2011-01-01

    This project incorporates technology and a historical emphasis on science drawn from ancient civilizations to promote a greater understanding of conceptual science. In the Apps for Ancient Civilizations project, students investigate an ancient culture to discover how people might have used science and math smartphone apps to make their lives…

  6. Sencha Architect app development

    CERN Document Server

    Groner, Loiane

    2013-01-01

    A standard tutorial-based approach for using Sencha Architect to develop applications in Ext JS and Sencha Touch.Sencha Architect App Development is for Ext JS and Sencha Touch developers that are looking to improve their productivity by using Sencha Architect for app development. Basic knowledge of Ext JS and Sencha Touch is required.

  7. Akut ultralyd App

    DEFF Research Database (Denmark)

    Todsen, Tobias; Graumann, Ole; Laursen, Christian B.;

    2015-01-01

    Denne app indeholder gennemgang af en række standardiserede ultralydsprotokoller, der kan udføres i forbindelse med undersøgelsen af den akutte patient til besvarelse af binære kliniske spørgsmål. App'en er blevet udviklet i et samarbejde mellem Københavns Universitet, Syddansk Universitet og...... Aarhus Universitet. Projektgruppen repræsenterer læger fra forskellige specialer og har alle beskæftiget sig med undervisning og forskning i klinisk ultralyd. App´en er gratis og kan hestes her: http://akutul.cekuapp.dk/...

  8. Using Google App Engine

    CERN Document Server

    Severance, Charles

    2009-01-01

    Build exciting, scalable web applications quickly and confidently using Google App Engine and this book, even if you have little or no experience in programming or web development. App Engine is perhaps the most appealing web technology to appear in the last year, providing an easy-to-use application framework with basic web tools. While Google's own tutorial assumes significant experience, Using Google App Engine will help anyone get started with this platform. By the end of this book, you'll know how to build complete, interactive applications and deploy them to the cloud using the same s

  9. Negotiating mobile app permissions

    OpenAIRE

    Baarslag, Tim; Liccardi, Ilaria; Gerding, Enrico H.; Gomer, Richard; m. c. schraefel

    2015-01-01

    We propose a design in which the user can negotiate a mobile app's permissions to access their personal data. For example, users who prefer not to view ads could opt to pay an additional fee for this. However, negotiating with each app might be cumbersome and difficult to achieve by users. Hence, to make this process easier, we propose an approach that uses an agent-based framework that employs software agents to represent users in their privacy negotiation with the app in an automated manner.

  10. La experiencia española en concesiones y APPs: Ferrocarriles, metros, tranvías y otras infraestructuras de transporte urbano y metropolitano

    OpenAIRE

    Andrés Rebollo

    2009-01-01

    El presente documento es el capítulo 3 de un informe de consultoría sobre las asociaciones público-privadas (APPs) en España, donde se hace un somero recorrido sobre la evolución de fórmulas que han producido su gran desarrollo en los últimos 10 años, identificando los principales rasgos de la tradición y práctica española en materia de APPs y analizando detalladamente las motivaciones, marco jurídico y modalidades de contratación. En este capítulo se expone la experiencia española en el desa...

  11. Orthodontic apps at fingertips

    OpenAIRE

    Baheti, Mayuresh Jagannath; Toshniwal, Nandlal

    2014-01-01

    Background Smartphone usage has spread to many settings including that of healthcare and dentistry with numerous potential and realized benefits. The ability to download custom-built software applications (apps) has created new opportunities for orthodontists to integrate technology into clinical practice and patients to collect the information about orthodontics and help them during their treatment. The purpose of this study is to provide a summary of the orthodontic apps currently available...

  12. Designing apps for success developing consistent app design practices

    CERN Document Server

    David, Matthew

    2014-01-01

    In 2007, Apple released the iPhone. With this release came tools as revolutionary as the internet was to businesses and individuals back in the mid- and late-nineties: Apps. Much like websites drove (and still drive) business, so too do apps drive sales, efficiencies and communication between people. But also like web design and development, in its early years and iterations, guidelines and best practices for apps are few and far between.Designing Apps for Success provides web/app designers and developers with consistent app design practices that result in timely, appropriate, and efficiently

  13. Governance mechanisms for healthcare apps

    DEFF Research Database (Denmark)

    Manikas, Konstantinos; Hansen, Klaus Marius; Kyng, Morten

    2014-01-01

    The introduction of the `app store' concept has challenged the way software is distributed and marketed: developers have easier access to customers, while customers have easy access to innovative applications. Apps today are increasingly focusing on more "mission-critical" areas like healthcare...... with the Apple AppStore counting more than 40,000 apps under the category "health & fitness". This rapid development of healthcare apps increases the necessity of governance as, currently, healthcare apps are not thoroughly governed. The U.S. Food and Drug Administration and the European Commission only have...

  14. Pro Android Apps Performance Optimization

    CERN Document Server

    Guihot, Hervé

    2012-01-01

    Today's Android apps developers are often running into the need to refine, improve and optimize their apps performances. As more complex apps can be created, it is even more important for developers to deal with this critical issue. Android allows developers to write apps using Java, C or a combination of both with the Android SDK and the Android NDK. Pro Android Apps Performance Optimization reveals how to fine-tune your Android apps, making them more stable and faster. In this book, you'll learn the following: * How to optimize your Java code with the SDK, but also how to write and optimize

  15. Security Ads in Mobile Apps

    Directory of Open Access Journals (Sweden)

    Manasvi Kalra,

    2016-02-01

    Full Text Available The apps consist of advertisements to promote their products. Not all of them are appropriate to resume. Therefore various algorithms have been used in order to block those apps from existence but none of them is completely successful. In our app we are using an antivirus which can by default block those spy apps and remove them from the web page. The algorithm which has been used makes use of various ant viruses in the background which detect irrelevant and intimate apps and then our algorithm will demolish them. Certain apps are non-trustworthy where one click can spy all the mobile data. They block those apps and works on security. We are working on secure ads for mobile apps. It can also work as a basic antivirus where it detects the viruses like malwares in any of your installed apps or downloads. It will create a popup of discarding or keeping it. Mobile applications can be downloaded from anywhere like amazon, googleplay, apps store etc. There is no rigorous verification of an application when it is uploaded to the market. One can easily develop a malicious application and upload it to the app market. The user itself is responsible for accepting the risk of an app available from secondary markets. Therefore, we have decided to develop this app to make the market more secure and bounded. In future, It will take the mobile market while consuming minimal additional resources and preserving user privacy.

  16. Cuisine Ireland 'APP'

    OpenAIRE

    Seberry, Dermot

    2014-01-01

    Description Cuisine Ireland contains 15 samplerecipes from renowned Irish chef and author Dermot Seberry. Taking you to the heart of ancient Ireland, from the most northern beauty of the Mourne & Cooley peninsula along the magnificent east coastline and across to the Boyne Valley, the focus of this app is on the very best the region has to offer food tourists and local chefs. This app was developed as a companion piece to Dermot’s new book “Ireland, A Culinary Journey of the North East”. T...

  17. Instant AppFog

    CERN Document Server

    Wee, Pau Kiat

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. This easy to follow, hands-on guide shows you how to deploy and manage your application within minutes.Instant AppFog Starter is great for developers who are new to AppFog and who are primarily working on code rather than infrastructure. This book is perfect for those who are looking to publish applications without an in-depth knowledge of servers, firewalls, and networking. It is assumed that you will have some experience of web development as

  18. Quantifying App Store Dynamics: Longitudinal Tracking of Mental Health Apps

    Science.gov (United States)

    Nicholas, Jennifer; Christensen, Helen

    2016-01-01

    Background For many mental health conditions, mobile health apps offer the ability to deliver information, support, and intervention outside the clinical setting. However, there are difficulties with the use of a commercial app store to distribute health care resources, including turnover of apps, irrelevance of apps, and discordance with evidence-based practice. Objective The primary aim of this study was to quantify the longevity and rate of turnover of mental health apps within the official Android and iOS app stores. The secondary aim was to quantify the proportion of apps that were clinically relevant and assess whether the longevity of these apps differed from clinically nonrelevant apps. The tertiary aim was to establish the proportion of clinically relevant apps that included claims of clinical effectiveness. We performed additional subgroup analyses using additional data from the app stores, including search result ranking, user ratings, and number of downloads. Methods We searched iTunes (iOS) and the Google Play (Android) app stores each day over a 9-month period for apps related to depression, bipolar disorder, and suicide. We performed additional app-specific searches if an app no longer appeared within the main search Results On the Android platform, 50% of the search results changed after 130 days (depression), 195 days (bipolar disorder), and 115 days (suicide). Search results were more stable on the iOS platform, with 50% of the search results remaining at the end of the study period. Approximately 75% of Android and 90% of iOS apps were still available to download at the end of the study. We identified only 35.3% (347/982) of apps as being clinically relevant for depression, of which 9 (2.6%) claimed clinical effectiveness. Only 3 included a full citation to a published study. Conclusions The mental health app environment is volatile, with a clinically relevant app for depression becoming unavailable to download every 2.9 days. This poses

  19. CLAS App ML

    NARCIS (Netherlands)

    Maher, Bridget; Hartkopf, Kathleen; Stieger, Lina; Schroeder, Hanna; Sopka, Sasa; Orrego, Carola; Drachsler, Hendrik

    2014-01-01

    This is a multi-language (ML) update of the CLAS App original design by Bridget Maher from the School of Medicine at University College Cork, Ireland. The current version has an improve counting mechanism and has been translated from English to Spanish, Catalan and German languages within the Europe

  20. Knoflook remt App

    NARCIS (Netherlands)

    Mul, M.F.; Becker, P.M.; Peet-Schwering, van der C.M.C.; Wikselaar, van P.G.; Wisselink, H.J.; Stockhofe, N.

    2011-01-01

    De Animal Sciences Group van Wageningen UR heeft in opdracht van biologische varkenshouders onderzocht of het mogelijk is om in plaats van antibiotica, knoflook te gebruiken voor de bestrijding van longontsteking door de bacterie Actinobacillus pleuropneumoniae (App). Uit de resultaten blijkt dat Al

  1. There's an App for that!

    Science.gov (United States)

    Dutton, Gail

    2011-01-01

    Important as training the sales force is, mobile training apps are being used for much more. Visual Eyes Inc., for example, has developed training apps for the U.S. military's combat medical teams that detail specific medical procedures, such as controlling hemorrhaging. Other apps, developed for corporations and government agencies, pass along…

  2. Anterograde amnesia as a possible postoperative complication of Midazolam as an agent for intravenous conscious sedation.

    Science.gov (United States)

    Malamed, S F; Nikchevich, D; Block, J

    1988-01-01

    Anterograde amnesia is often considered to be a beneficial effect of intravenous conscious sedation. The recently introduced benzodiazepine, midazolam, has associated with its administration a significant anterograde amnesic period. In the case presented here, a healthy young female presented for third molar extraction under midazolam conscious sedation and local anesthesia. After uncomplicated removal of the teeth and clinically adequate recovery from sedation, it was noted that the patient had swallowed the postsurgical gauze packs. Efforts at recovery of the gauze packs were futile. Follow-up discussion with the patient revealed a complete lack of recall of all events occurring for up to an hour or more after the administration of intravenous midazolam. The need for written and oral postoperative instructions to both the patient and his/her escort is emphasized.

  3. Hypothermia-induced anterograde amnesia: is memory loss attributable to impaired acquisition?

    Science.gov (United States)

    Santucci, A C; Kasenow, P M; Riccio, D C; Richardson, R

    1987-07-01

    The present investigation examined whether the poor test performance observed in studies of anterograde amnesia reflects a memory deficit or is a by-product of weaker initial learning resulting from impaired sensory, motivational, or associative processes. Two experiments were performed which utilized latent extinction (Experiment 1) and delay of punishment (Experiment 2) manipulations in order to assess the nature of original learning in rats trained under either hypothermic (29 degrees C) or normothermic conditions. Results from both experiments provided evidence that hypothermia treatment administered prior to training had relatively little influence on the animal's ability to acquire a passive avoidance response. Therefore, the rapid forgetting observed in hypothermia-induced anterograde amnesia is most likely due to memory deficits rather than an artifact of poorer acquisition. PMID:3632548

  4. Anterograde jejunojejunal intussusception resulted in acute efferent loop syndrome after subtotal gastrectomy

    Institute of Scientific and Technical Information of China (English)

    Jung; Myun; Kwak; Jin; Kim; Sung; Ock; Suh

    2010-01-01

    Postoperative intussusception is an unusual clinical entity in adults,and is rarely encountered as a complication following gastric surgery.The most common type after gastric surgery is retrograde jejunogastric intussusception,and jejunojejunal intussusception has been rarely reported.We report a case of anterograde jejunojejunal intussusception after radical subtotal gastrectomy with Billroth Ⅱ anastomosis in a 38-year-old Korean woman with early gastric cancer,and include a review of the literature on thi...

  5. Oyster Fisheries App

    Science.gov (United States)

    Perez Guerrero, Geraldo A.; Armstrong, Duane; Underwood, Lauren

    2015-01-01

    This project is creating a cloud-enabled, HTML 5 web application to help oyster fishermen and state agencies apply Earth science to improve the management of this important natural and economic resource. The Oyster Fisheries app gathers and analyzes environmental and water quality information, and alerts fishermen and resources managers about problems in oyster fishing waters. An intuitive interface based on Google Maps displays the geospatial information and provides familiar interactive controls to the users. Alerts can be tailored to notify users when conditions in specific leases or public fishing areas require attention. The app is hosted on the Amazon Web Services cloud. It is being developed and tested using some of the latest web development tools such as web components and Polymer.

  6. Effects of curcumin on expression of hippocampal glucose transporter of APP/PS1 double transgenic mice%姜黄素对APP/PS1双转基因小鼠脑葡萄糖转运子表达的影响

    Institute of Scientific and Technical Information of China (English)

    党惠子; 王虹; 李瑞晟; 任映; 杨金铎; 王蓬文

    2014-01-01

    目的 采用Morris水迷宫检测小鼠空间学习记忆和记忆保持能力,评价姜黄素对APP/PS1双转基因小鼠认知功能的影响,并观察姜黄素对APP/PS1双转基因小鼠以及海马葡萄糖转运子1(GLUT1)和GLUT3表达的影响,从脑能量代谢的角度探讨姜黄素神经保护作用的机制. 方法 将3月龄APP/PS1双转基因小鼠随机分为模型(APP/PS1+ VEH)组,罗格列酮(APP/PS1+ RSG)组,姜黄素大(APP/PS1+curcumin-H)、中(APP/PS1+ curcumin-M)、小剂量(APP/PS1+ curcumin-L)组.灌胃3个月后,应用免疫组织化学和Western blot方法进行检测. 结果 Morris水迷宫撤台实验中,与正常对照(NC)组比较,APP/PS1+VEH组穿越平台次数减少,且目标象限停留时间缩短(P<0.01);与APP/PS1+ VEH组相比,APP/PS1+curcumin-M组穿越平台次数增加(P<0.01).免疫组织化学染色,与APP/PS1+ VEH组相比,APP/PS1+ curcumin-H、APP/PS1+ curcumin-M组海马CA1区GLUT1阳性细胞增加(P<0.05);APP/PS1+ curcumin-M组GLUT3阳性细胞计数明显增加(P<0.01),APP/PS1+curcumin-H组GLUT3阳性细胞增加(P<0.05).Western blot结果与免疫组织化学结果基本一致.结论 姜黄素可改善APP/PS1双转基因小鼠的空间学习记忆和记忆保持能力,影响脑葡萄糖代谢有关的GLUT1和GLUT3蛋白的表达而发挥神经保护作用.

  7. Mobile Apps for Educational Purposes.

    Science.gov (United States)

    Pilcher, Jobeth

    2016-01-01

    With the growing number of mobile resources, nurse educators and professional development practitioners have the opportunity to harness mobile applications as a tool for their education toolbox. Yet, the overwhelming availability of choices can lead to questions, such as the following: How do we locate apps without spending huge amounts of our valuable time? How do we know which apps to choose? How can we evaluate apps? This article is aimed at addressing these questions. PMID:27575934

  8. Amazing Android Apps For Dummies

    CERN Document Server

    Begun, Daniel A

    2011-01-01

    Find the Android apps that are right for you so you can have fun and get more done!The popularity of Android apps is exploding and this handy guide helps you sort through the thousands of available applications so you can find the ones that are ideal for you. You'll explore a variety of apps in the areas of entertainment, finance, health, food, music, news, weather, photography, reference, dining out, social networking, sports, travel, and more. Author Daniel Begun helps you navigate through this enormous-and potentially overwhelming-array of Android apps.Holds your hand through the oftentimes

  9. Pro Java ME Apps

    CERN Document Server

    Iliescu, Ovidiu

    2011-01-01

    Pro Java ME Apps gives you, the developer, the know-how required for writing sophisticated Java ME applications and for taking advantage of this huge potential market. Java ME is the largest mobile software platform in the world, supported by over 80% of all phones. You'll cover what Java ME is and how it compares to other mobile software platforms, how to properly design and structure Java ME applications, how to think like an experienced Java ME developer, what common problems and pitfalls you may run into, how to optimize your code, and many other key topics. Unlike other Java ME books out

  10. DingDong App

    OpenAIRE

    Langreo i Puiggrós, Glòria

    2013-01-01

    DingDong App és una aplicació per a iPad feta amb la finalitat que els nens i nenes es familiaritzin amb certes freqüències sonores, corresponents a una octava musical bàsica. L'aplicació està basada en els principis d'educació de la doctora Maria Montessori i del professor Edgar Willems, amb els quals la informació i el coneixement s'adquireixen mitjançant la pròpia experiència del joc.

  11. The CLAS App - A training app to improve medical handovers

    NARCIS (Netherlands)

    Maher, Bridget; Drachsler, Hendrik; Kalz, Marco; Marcus, Specht

    2012-01-01

    Maher, B., Drachsler, H., Kalz, M., & Specht, M. (2012, 16-18 October). The CLAS App - A training app to improve medical handovers. Presentation at the 11th World Conference on Mobile and Contextual Learning, Helsinki, Finland. Please see also: http://hdl.handle.net/1820/4613

  12. KWIN nu ook als app

    NARCIS (Netherlands)

    Rotgers, G.; Vermeij, I.

    2014-01-01

    KWIN, Kwantitatieve Informatie Veehouderij, verscheen de afgelopen 25 jaar als lijvig handboek, zowel op papier als digitaal. Dit najaar is daar een serie apps bij gekomen, waarmee adviseurs en veehouders zelf saldo- en kostprijsberekeningen kunnen maken. De apps zijn beschikbaar voor de pluimvee-,

  13. Gebruikersdata bij abonnementen in app stores

    OpenAIRE

    Roosendaal, A.P.C.; Nieuwenhuis, O.A.

    2013-01-01

    Kranten en tijdschriften bieden tegenwoordig vaak, naast de papieren edities, digitale abonnementen aan. De content wordt in dat geval via een app gelezen op een mobiele device, zoals een smartphone of tablet. Om abonnementen in deze vorm aan te kunnen bieden is het bouwen van een app noodzakelijk. Deze app wordt vervolgens aangeboden in een app store, zoals Google Play of de Apple app store. De app store provider ontvangt een percentage van de verkoopprijs van het abonnement als vergoeding v...

  14. Your Life in Web Apps

    CERN Document Server

    Turnbull, Giles

    2008-01-01

    What is a web app? It's software that you use right in your web browser. Rather than installing an application on your computer, you visit a web site and sign up as a new user of its software. Instead of storing your files on your own hard disk, the web app stores them for you, online. Is it possible to switch entirely to web apps? To run nothing but a browser for an entire day? In this PDF we'll take you through one day in the life of a web apps-only user and chronicle the pros and cons of living by browser. And if the idea of switching, fully or partially, to web apps sounds appealing to

  15. Best iPhone Apps

    CERN Document Server

    Biersdorfer, J

    2010-01-01

    With over 250,000 apps to choose from in Apple's App Store, you can make your iPhone or iPod Touch do just about anything you can imagine -- and almost certainly a few things you would never think of. While it's not hard to find apps, it is frustratingly difficult to find the the best ones. That's where this new edition of Best iPhone Apps comes in. New York Times technology columnist J.D. Biersdorfer has stress-tested hundreds of the App Store's mini-programs and hand-picked more than 200 standouts to help you get work done, play games, stay connected with friends, explore a new city, get i

  16. Selecting "App"ealing and "App"ropriate Book Apps for Beginning Readers

    Science.gov (United States)

    Cahill, Maria; McGill-Franzen, Anne

    2013-01-01

    Beginning with a brief rationale for selecting quality digital picture book apps for beginning readers, the authors describe the elements of digital picture books and provide a brief review of the instructional benefits of digital picture book use for beginning readers. They then present a detailed taxonomy for selecting quality picture book apps.…

  17. Anterograde trafficking of KCa3.1 in polarized epithelia is Rab1- and Rab8-dependent and recycling endosome-independent.

    Directory of Open Access Journals (Sweden)

    Claudia A Bertuccio

    Full Text Available The intermediate conductance, Ca2+-activated K+ channel (KCa3.1 targets to the basolateral (BL membrane in polarized epithelia where it plays a key role in transepithelial ion transport. However, there are no studies defining the anterograde and retrograde trafficking of KCa3.1 in polarized epithelia. Herein, we utilize Biotin Ligase Acceptor Peptide (BLAP-tagged KCa3.1 to address these trafficking steps in polarized epithelia, using MDCK, Caco-2 and FRT cells. We demonstrate that KCa3.1 is exclusively targeted to the BL membrane in these cells when grown on filter supports. Following endocytosis, KCa3.1 degradation is prevented by inhibition of lysosomal/proteosomal pathways. Further, the ubiquitylation of KCa3.1 is increased following endocytosis from the BL membrane and PR-619, a deubiquitylase inhibitor, prevents degradation, indicating KCa3.1 is targeted for degradation by ubiquitylation. We demonstrate that KCa3.1 is targeted to the BL membrane in polarized LLC-PK1 cells which lack the μ1B subunit of the AP-1 complex, indicating BL targeting of KCa3.1 is independent of μ1B. As Rabs 1, 2, 6 and 8 play roles in ER/Golgi exit and trafficking of proteins to the BL membrane, we evaluated the role of these Rabs in the trafficking of KCa3.1. In the presence of dominant negative Rab1 or Rab8, KCa3.1 cell surface expression was significantly reduced, whereas Rabs 2 and 6 had no effect. We also co-immunoprecipitated KCa3.1 with both Rab1 and Rab8. These results suggest these Rabs are necessary for the anterograde trafficking of KCa3.1. Finally, we determined whether KCa3.1 traffics directly to the BL membrane or through recycling endosomes in MDCK cells. For these studies, we used either recycling endosome ablation or dominant negative RME-1 constructs and determined that KCa3.1 is trafficked directly to the BL membrane rather than via recycling endosomes. These results are the first to describe the anterograde and retrograde trafficking of KCa3

  18. Getting started with Google Apps

    CERN Document Server

    Darbyshire, Paul

    2012-01-01

    First or one of the first books on now Final version (no longer Beta) of Google Apps with coverage of the new Chrome OS. Google Apps is expected to be a leading suite of ""Office-like"" online applications, free for the consumer and only 50 per year for business licenses. Google Apps already has over 1 Million business users and more consumer users, as of mid 2009 - to be showcased on Chrome enabled Netbooks (3-4) and Android Smart phones (up to 20) at Consumer Electronics Show (CES) in January 2010.

  19. Android app development for dummies

    CERN Document Server

    Burton, Michael

    2015-01-01

    The updated edition of the bestselling guide to Android app development If you have ambitions to build an Android app, this hands-on guide gives you everything you need to dig into the development process and turn your great idea into a reality! In this new edition of Android App Development For Dummies, you'll find easy-to-follow access to the latest programming techniques that take advantage of the new features of the Android operating system. Plus, two programs are provided: a simple program to get you started and an intermediate program that uses more advanced aspects of the Android plat

  20. Creating Innovative Student Projects with App Smashing

    Science.gov (United States)

    Young, Donna

    2014-01-01

    The potential for using various apps to improve student learning is tremendous. Yet, despite the iPad's possibilities, apps are often limited in their functionality. No one has created that magical, one-size-fits-all app that accomplishes all of the tasks that you had in mind. Luckily, there is an answer to this common problem: app smashing.…

  1. Smartphone use in neurosurgery? APP-solutely!

    Directory of Open Access Journals (Sweden)

    Michael Zaki

    2014-01-01

    Conclusions: There are a number of neurosurgery-themed apps available to all audiences. There was a lack of patient information apps for nonspinal procedures. Most apps did not have enough reviews to evaluate their quality. There was also a lack of oversight to validate the accuracy of medical information provided in these apps.

  2. Een eigen Bibliotheek-app

    NARCIS (Netherlands)

    den Hollander, Franciscus; Veldkamp, Jan Herman

    2013-01-01

    Al enige tijd bestond bij de Bibliotheek RUG het verlangen om de producten en diensten van de bibliotheek op eigentijdse wijze onder de aandacht te brengen van haar gebruikers. Via een app op de mobiele telefoon, dus.

  3. Python for Google app engine

    CERN Document Server

    Pippi, Massimiliano

    2015-01-01

    If you are a Python developer, whether you have experience in web applications development or not, and want to rapidly deploy a scalable backend service or a modern web application on Google App Engine, then this book is for you.

  4. Developing an emergency ultrasound app

    DEFF Research Database (Denmark)

    Foss, Kim Thestrup; Subhi, Yousif; Aagaard, Rasmus;

    2015-01-01

    Focused emergency ultrasound is rapidly evolving as a clinical skill for bedside examination by physicians at all levels of education. Ultrasound is highly operator-dependent and relevant training is essential to ensure appropriate use. When supplementing hands-on focused ultrasound courses, e......-learning can increase the learning effect. We developed an emergency ultrasound app to enable onsite e-learning for trainees. In this paper, we share our experiences in the development of this app and present the final product....

  5. Instant Citrix XenApp

    CERN Document Server

    Mallett, Andrew

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. This book is a great tool to quickly learn and explore the features offered by XenApp 6.5.Windows system administrators who want a quick lesson on how to install and configure XenApp.

  6. Can postictal suppression of the perforant path - fascia dentata responses account for the ECS-induced anterograde amnesia in rats?

    Science.gov (United States)

    Peréz-Saad, H; Valousková, V; Bures, J

    1984-07-15

    Electroconvulsive shock (ECS) decreases fascia dentata responses to entorhinal stimulation by 50% in unanesthetized rats. Synaptic potentials and population spikes return to pre-ECS level during 1 h and 3 h, respectively. This recovery rate is compared with the dynamics of ECS-induced anterograde amnesia.

  7. Anterograde effects of a single electroconvulsive shock on inhibitory avoidance and on cued fear conditioning

    Directory of Open Access Journals (Sweden)

    Oliveira M.G.M.

    1998-01-01

    Full Text Available A single electroconvulsive shock (ECS or a sham ECS was administered to male 3-4-month-old Wistar rats 1, 2, and 4 h before training in an inhibitory avoidance test and in cued classical fear conditioning (measured by means of freezing time in a new environment. ECS impaired inhibitory avoidance at all times and, at 1 or 2 h before training, reduced freezing time before and after re-presentation of the ECS. These results are interpreted as a transient conditioned stimulus (CS-induced anxiolytic or analgesic effect lasting about 2 h after a single treatment, in addition to the known amnesic effect of the stimulus. This suggests that the effect of anterograde learning impairment is demonstrated unequivocally only when the analgesic/anxiolytic effect is over (about 4 h after ECS administration and that this impairment of learning is selective, affecting inhibitory avoidance but not classical fear conditioning to a discrete stimulus.

  8. Anterograde removal of broken femoral nails without opening the nonunion site: a new technique

    Directory of Open Access Journals (Sweden)

    Henrique Antônio Berwanger de Amorim Cabrita

    2010-01-01

    Full Text Available OBJECTIVE: We describe a new technique for removing the distal fragments of broken intramedullary femoral nails without disturbing the nonunion site. METHODS: This technique involves the application of an AO distractor prior to the removal of the nail fragments, with subsequent removal of the proximal nail fragment in an anterograde fashion and removal of the distal fragment through a medial parapatellar approach. Impaction of the fracture site is then performed with a nail that is broader than the remaining fragmented material. RESULTS: Nails were removed from five patients using the technique described above without any complications. After a mean follow-up period of 61.8 months, none of these patients showed worsened knee osteoarthritis. CONCLUSION: The original technique described in this article allows surgeons to remove the distal fragment of fractured femoral intramedullary nails without opening the nonunion focus or using special surgical instruments.

  9. Unexpected anterograde amnesia associated with Buscopan used as a predmedication for endocscopy

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    It has been known that peripheral adverse event is caused by peripheral antimuscarinic action, from hyoscine butylbromide (Buscopan; Boehringer Ingelheim, Germany)used as a premedication for endoscopy. However,symptoms or signs associated with the central nervous system are rarely reported in the field of anesthesiology and peripartum labor. This central anticholinergic syndrome is likely caused by blockade of muscarinic cholinergic receptors in the central nervous system. There is no report on Buscopan-induced central anticholinergic syndrome in endoscopy room so far. Three middle-aged females unexpectedly suffered from anterograde amnesia after intramuscular injection of hyoscine butylbromide as an antispasmodic premedication for endoscopy at our endoscopy unit in the Health Promotion Center.

  10. Native Apps versus Web Apps: which is best for healthcare applications?

    OpenAIRE

    Selvarajah, Kirusnapillai; Craven, Michael P; Massey, Adam; Crowe, John; Vedhara, Kavita; Raine-Fenning, Nick

    2013-01-01

    Smartphone applications (Apps) provide a new way to deliver healthcare, illustrated by the fact that healthcare Apps are estimated to make up over 30% of new Apps currently being developed; with this number seemingly set to increase as the benefits become more apparent. In this paper, using the development of an In Vitro Fertilisation (IVF) treatment stress study App as the exemplar, the alternatives of Native App and Web App design and implementa-tion are considered across several factors th...

  11. Psych-related iPhone apps.

    Science.gov (United States)

    Harrison, Anthony Mark; Goozee, Rhianna

    2014-02-01

    iPhone apps are a widely utilised technology that have recently been identified as a useful medium for health research, clinical interventions and education. While some researchers have discussed advances in app technology, others promote specific apps that are not free to access. To our knowledge, no study has conducted a review of current, free iPhone apps related to psychology, psychiatry and mental health. Therefore, we conducted a pilot, web-based review exploring free iPhone apps using a replicable search strategy within the iTunes Store search function. A selection of apps were selected and subjectively assessed in terms of their usability, utility, graphics, and associated costs for the consumer. We concluded that the apps reviewed, though novel, are limited in their scope and utility. We also note a significant gap in more scientific, evidence-based app technology, and pose some pertinent ethical questions when developing future psych-related apps.

  12. APP Snrinn Edition Kicks Off

    Institute of Scientific and Technical Information of China (English)

    Tang Rong

    2012-01-01

    When European textile insiders still take delight in talking about the last apparel sourcing show in September 2011, the debut of APP Spring edition bring people back to the Le Bourget Expo Center, with entire passion. The 7th APP Show, sponsored by China National Textile and Apparel Council (CNTAC), organized by the Sub-Council of Textile Industry, China Council for the Promotion of International Trade (CCPIT TEX), China National Garment Association and Messe Frankfurt French Subsidiary, was on display from Feb 13th to 16th 2012,

  13. Android Apps for Absolute Beginners

    CERN Document Server

    Jackson, Wallace

    2011-01-01

    Anybody can start building simple apps for the Android platform, and this book will show you how! Android Apps for Absolute Beginners takes you through the process of getting your first Android applications up and running using plain English and practical examples. It cuts through the fog of jargon and mystery that surrounds Android application development, and gives you simple, step-by-step instructions to get you started.* Teaches Android application development in language anyone can understand, giving you the best possible start in Android development * Provides simple, step-by-step exampl

  14. Smartphone use in neurosurgery? APP-solutely!

    OpenAIRE

    Michael Zaki; Doniel Drazin

    2014-01-01

    Background: A number of smartphone medical apps have recently emerged that may be helpful for the neurosurgical patient, practitioner, and trainee. This study aims to review the current neurosurgery-focused apps available for the iPhone, iPad, and Android platforms as of December 2013. Methods: Two of the most popular smartphone app stores (Apple Store and Android Google Play Store) were surveyed for neurosurgery-focused apps in December 2013. Search results were categorized based on thei...

  15. The best 100 free apps for libraries

    CERN Document Server

    Hahn, Jim

    2013-01-01

    Librarian Jim Hahn has carefully culled the over 500,000 available apps down to the 100 that are the absolute best for day-in, day-out library services. The guide covers apps from both Apple and Android devices, including tablets. This guide is intended as an introduction for those with little or no app experience and for those wanting to know more about app uses for information access.

  16. MIT App Inventor: Enabling Personal Mobile Computing

    OpenAIRE

    Pokress, Shaileen Crawford; Veiga, José Juan Dominguez

    2013-01-01

    MIT App Inventor is a drag-and-drop visual programming tool for designing and building fully functional mobile apps for Android. App Inventor promotes a new era of personal mobile computing in which people are empowered to design, create, and use personally meaningful mobile technology solutions for their daily lives, in endlessly unique situations. App Inventor's intuitive programming metaphor and incremental development capabilities allow the developer to focus on the logic for programming ...

  17. A hereditary spastic paraplegia mutation in kinesin-1A/KIF5A disrupts neurofilament transport

    Directory of Open Access Journals (Sweden)

    Brown Anthony

    2010-11-01

    Full Text Available Abstract Background Hereditary spastic paraplegias are a group of neurological disorders characterized by progressive distal degeneration of the longest ascending and descending axons in the spinal cord, leading to lower limb spasticity and weakness. One of the dominantly inherited forms of this disease (spastic gait type 10, or SPG10 is caused by point mutations in kinesin-1A (also known as KIF5A, which is thought to be an anterograde motor for neurofilaments. Results We investigated the effect of an SPG10 mutation in kinesin-1A (N256S-kinesin-1A on neurofilament transport in cultured mouse cortical neurons using live-cell fluorescent imaging. N256S-kinesin-1A decreased both anterograde and retrograde neurofilament transport flux by decreasing the frequency of anterograde and retrograde movements. Anterograde velocity was not affected, whereas retrograde velocity actually increased. Conclusions These data reveal subtle complexities to the functional interdependence of the anterograde and retrograde neurofilament motors and they also raise the possibility that anterograde and retrograde neurofilament transport may be disrupted in patients with SPG10.

  18. Color Addition and Subtraction Apps

    Science.gov (United States)

    Ruiz, Frances; Ruiz, Michael J.

    2015-01-01

    Color addition and subtraction apps in HTML5 have been developed for students as an online hands-on experience so that they can more easily master principles introduced through traditional classroom demonstrations. The evolution of the additive RGB color model is traced through the early IBM color adapters so that students can proceed step by step…

  19. Electronic Discharge Letter Mobile App

    NARCIS (Netherlands)

    Lezcano, Leonardo; Triana, Michel; Ternier, Stefaan; Hartkopf, Kathleen; Stieger, Lina; Schroeder, Hanna; Sopka, Sasa; Drachsler, Hendrik; Maher, Bridget; Henn, Patrick; Orrego, Carola; Marcus, Specht

    2014-01-01

    The electronic discharge letter mobile app takes advantage of Near Field Communication (NFC) within the PATIENT project and a related post-doc study. NFC enabled phones to read passive RFID tags, but can also use this short-range wireless technology to exchange (small) messages. NFC in that sense co

  20. App Inventor for Android Build Your Own Apps - No Experience Required!

    CERN Document Server

    Tyler, Jason

    2011-01-01

    Create Android mobile apps, no programming required! Even with limited programming experience, you can easily learn to create apps for the Android platform with this complete guide to App Inventor for Android. App Inventor for Android is a visual language that relies on simple programming blocks that users can drag and drop to create apps. This handy book gives you a series of fully worked-out apps, complete with their programming blocks, which you can customize for your own use or use as a starting point for creating the next killer app. And it's all without writing a single line of code. Don

  1. Citrix XenApp performance essentials

    CERN Document Server

    Dentella, Luca

    2013-01-01

    A practical hands-on tutorial including multiple examples on application management using Citrix XenApp 6.5.Citrix XenApp Performance Essentials is intended for IT architects and system administrators who work with Citrix XenApp and who need an agile, practical guide to tune and optimize the performance.

  2. Capitalizing on App Development Tools and Technologies

    Science.gov (United States)

    Luterbach, Kenneth J.; Hubbell, Kenneth R.

    2015-01-01

    Instructional developers and others creating apps must choose from a wide variety of app development tools and technologies. Some app development tools have incorporated visual programming features, which enable some drag and drop coding and contextual programming. While those features help novices begin programming with greater ease, questions…

  3. Medical apps in need of optical microspectrometers

    NARCIS (Netherlands)

    Wolffenbuttel, R.F.; Wolffenbuttel Hosli, T.M.

    2016-01-01

    Apps have been used for providing additional user functionality on demand to the smartphone. Several highly promising medical apps have been introduced that rely on the build-in camera. However, some of these apps fall short of the expectations, due to the inherent limitation of the camera to operat

  4. Retrosplenial Cortical Contributions to Anterograde and Retrograde Memory in the Monkey.

    Science.gov (United States)

    Buckley, Mark J; Mitchell, Anna S

    2016-06-01

    Primate retrosplenial cortex (RSC) is important for memory but patient neuropathologies are diffuse so its key contributions to memory remain elusive. This study provides the first causal evidence that RSC in macaque monkeys is crucial for postoperative retention of preoperatively and postoperatively acquired memories. Preoperatively, monkeys learned 300 object-in-place scene discriminations across sessions. After RSC removal, one-trial postoperative retention tests revealed significant retrograde memory loss for these 300 discriminations relative to unoperated control monkeys. Less robust evidence was found for a deficit in anterograde memory (new postoperative learning) after RSC lesions as new learning to criterion measures failed to reveal any significant learning impairment. However, after achieving ≥90% learning criterion for the postoperatively presented novel 100 object-in-place scene discriminations, short-term retention (i.e., measured after 24 h delay) of this well-learnt set was impaired in the RSC monkeys relative to controls. A further experiment assessed rapid "within" session acquisition of novel object-in-place scene discriminations, again confirming that new learning per se was unimpaired by bilateral RSC removal. Primate RSC contributes critically to memory by supporting normal retention of information, even when this information does not involve an autobiographical component. PMID:26946129

  5. Retrosplenial Cortical Contributions to Anterograde and Retrograde Memory in the Monkey.

    Science.gov (United States)

    Buckley, Mark J; Mitchell, Anna S

    2016-06-01

    Primate retrosplenial cortex (RSC) is important for memory but patient neuropathologies are diffuse so its key contributions to memory remain elusive. This study provides the first causal evidence that RSC in macaque monkeys is crucial for postoperative retention of preoperatively and postoperatively acquired memories. Preoperatively, monkeys learned 300 object-in-place scene discriminations across sessions. After RSC removal, one-trial postoperative retention tests revealed significant retrograde memory loss for these 300 discriminations relative to unoperated control monkeys. Less robust evidence was found for a deficit in anterograde memory (new postoperative learning) after RSC lesions as new learning to criterion measures failed to reveal any significant learning impairment. However, after achieving ≥90% learning criterion for the postoperatively presented novel 100 object-in-place scene discriminations, short-term retention (i.e., measured after 24 h delay) of this well-learnt set was impaired in the RSC monkeys relative to controls. A further experiment assessed rapid "within" session acquisition of novel object-in-place scene discriminations, again confirming that new learning per se was unimpaired by bilateral RSC removal. Primate RSC contributes critically to memory by supporting normal retention of information, even when this information does not involve an autobiographical component.

  6. Y682 mutation of amyloid precursor protein promotes endo-lysosomal dysfunction by disrupting APP-SorLA interaction

    Directory of Open Access Journals (Sweden)

    Luca Rosario La Rosa

    2015-04-01

    Full Text Available The intracellular transport and localization of amyloid precursor protein (APP are critical determinants of APP processing and β-amyloid peptide production, thus crucially important for the pathophysiology of Alzheimer’s disease (AD. Notably, the C-terminal Y682ENPTY687 domain of APP binds to specific adaptors controlling APP trafficking and sorting in neurons. Mutation on the Y682 residue to glycine (Y682G leads to altered APP sorting in hippocampal neurons that favors its accumulation in intracellular compartments and the release of soluble APPα. Such alterations induce premature aging and learning and cognitive deficits in APP Y682G mutant mice (APPYG/YG. Here, we report that Y682G mutation affects formation of the APP complex with sortilin-related receptor (SorLA, resulting in endo-lysosomal dysfunctions and neuronal degeneration. Moreover, disruption of the APP/SorLA complex changes the trafficking pathway of SorLA, with its consequent increase in secretion outside neurons. Mutations in the SorLA gene are a prognostic factor in AD, and increases in SorLA levels in cerebrospinal fluid are predictive of AD in humans. These results might open new possibilities in comprehending the role played by SorLA in its interaction with APP and in the progression of neuronal degeneration. In addition, they further underline the crucial role played by Y682 residue in controlling APP trafficking in neurons.

  7. Incredible iPad Apps For Dummies

    CERN Document Server

    LeVitus, Bob

    2010-01-01

    Fill your iPad with cool apps with help from this full-color directory!The popularity of the iPad is growing at an unstoppable rate and users are looking for help sorting through the tens of thousands of apps available in the App Store. Packed with helpful reviews and valuable tips on how to make the most of each app, this book walks you through the vast selection of apps and helps you narrow down the most essential and entertaining apps for your needs and interests. Mac guru Bob "Dr. Mac" LeVitus helps you uncover the best of the best apps in business, education, entertainment, finance, healt

  8. Apps of Steel: Are Exercise Apps Providing Consumers with Realistic Expectations?: A Content Analysis of Exercise Apps for Presence of Behavior Change Theory

    Science.gov (United States)

    Cowan, Logan T.; Van Wagenen, Sarah A.; Brown, Brittany A.; Hedin, Riley J.; Seino-Stephan, Yukiko; Hall, P. Cougar; West, Joshua H.

    2013-01-01

    Objective. To quantify the presence of health behavior theory constructs in iPhone apps targeting physical activity. Methods. This study used a content analysis of 127 apps from Apple's (App Store) "Health & Fitness" category. Coders downloaded the apps and then used an established theory-based instrument to rate each app's inclusion of…

  9. Learning System Center App Controller

    CERN Document Server

    Naeem, Nasir

    2015-01-01

    This book is intended for IT professionals working with Hyper-V, Azure cloud, VMM, and private cloud technologies who are looking for a quick way to get up and running with System Center 2012 R2 App Controller. To get the most out of this book, you should be familiar with Microsoft Hyper-V technology. Knowledge of Virtual Machine Manager is helpful but not mandatory.

  10. App Savvy Turning Ideas into iPad and iPhone Apps Customers Really Want

    CERN Document Server

    Yarmosh, Ken

    2010-01-01

    How can you make your iPad or iPhone app stand out in the highly competitive App Store? While many books simply explore the technical aspects of iPad and iPhone app design and development, App Savvy also focuses on the business, product, and marketing elements critical to pursuing, completing, and selling your app -- the ingredients for turning a great idea into a genuinely successful product. Whether you're a designer, developer, entrepreneur, or just someone with a unique idea, App Savvy explains every step in the process, with guidelines for planning a solid concept, engaging customers ea

  11. Hypnosis: There’s an App for that. A systematic review of hypnosis apps

    OpenAIRE

    Sucala, Madalina; Schnur, Julie B.; Glazier, Kimberly; Miller, Sarah J.; Green, Joseph P.; Montgomery, Guy H.

    2013-01-01

    The study systematically reviews the hypnosis apps available via iTunes that were compatible with iPhone or iPad. Of 1455 apps identified on iTunes, 407 met inclusion criteria and were further reviewed. Most common hypnosis app targets were: weight loss (23%), boosting self-esteem (20%), and relaxation/stress reduction (19%). 83% of apps delivered hypnosis via audio track, and 37% allowed tailoring. Less than 14% of apps reported disclaimers. None of the apps reported having been tested for e...

  12. An Android Communication App Forensic Taxonomy.

    Science.gov (United States)

    Azfar, Abdullah; Choo, Kim-Kwang Raymond; Liu, Lin

    2016-09-01

    Due to the popularity of Android devices and applications (apps), Android forensics is one of the most studied topics within mobile forensics. Communication apps, such as instant messaging and Voice over IP (VoIP), are one popular app category used by mobile device users, including criminals. Therefore, a taxonomy outlining artifacts of forensic interest involving the use of Android communication apps will facilitate the timely collection and analysis of evidentiary materials from such apps. In this paper, 30 popular Android communication apps were examined, where a logical extraction of the Android phone images was collected using XRY, a widely used mobile forensic tool. Various information of forensic interest, such as contact lists and chronology of messages, was recovered. Based on the findings, a two-dimensional taxonomy of the forensic artifacts of the communication apps is proposed, with the app categories in one dimension and the classes of artifacts in the other dimension. Finally, the artifacts identified in the study of the 30 communication apps are summarized using the taxonomy. It is expected that the proposed taxonomy and the forensic findings in this paper will assist forensic investigations involving Android communication apps. PMID:27443418

  13. Towards Better Understanding of App Functions

    Institute of Scientific and Technical Information of China (English)

    童永昕; 余洁莹; 陈雷

    2015-01-01

    Apps are attracting more and more attention from both mobile and web platforms. Due to the self-organized nature of the current app marketplaces, the descriptions of apps are not formally written and contain a lot of noisy words and sentences. Thus, for most of the apps, the functions of them are not well documented and thus cannot be captured by app search engines easily. In this paper, we study the problem of inferring the real functions of an app by identifying the most informative words in its description. In order to utilize and integrate the diverse information of the app corpus in a proper way, we propose a probabilistic topic model to discover the latent data structure of the app corpus. The outputs of the topic model are further used to identify the function of an app and its most informative words. We verify the effectiveness of the proposed methods through extensive experiments on two real app datasets crawled from Google Play and Windows Phone Store, respectively.

  14. An Android Communication App Forensic Taxonomy.

    Science.gov (United States)

    Azfar, Abdullah; Choo, Kim-Kwang Raymond; Liu, Lin

    2016-09-01

    Due to the popularity of Android devices and applications (apps), Android forensics is one of the most studied topics within mobile forensics. Communication apps, such as instant messaging and Voice over IP (VoIP), are one popular app category used by mobile device users, including criminals. Therefore, a taxonomy outlining artifacts of forensic interest involving the use of Android communication apps will facilitate the timely collection and analysis of evidentiary materials from such apps. In this paper, 30 popular Android communication apps were examined, where a logical extraction of the Android phone images was collected using XRY, a widely used mobile forensic tool. Various information of forensic interest, such as contact lists and chronology of messages, was recovered. Based on the findings, a two-dimensional taxonomy of the forensic artifacts of the communication apps is proposed, with the app categories in one dimension and the classes of artifacts in the other dimension. Finally, the artifacts identified in the study of the 30 communication apps are summarized using the taxonomy. It is expected that the proposed taxonomy and the forensic findings in this paper will assist forensic investigations involving Android communication apps.

  15. Windows 8 app projects XAML and C#

    CERN Document Server

    Vermeir, Nico

    2013-01-01

    Become a leading Windows 8 app developer by using Windows 8 App Projects - XAML and C# Edition to learn techniques, tools, and ideas to create successful, 5-star apps. Windows 8 App Projects - XAML and C# Edition shows you the nuts and bolts of the Windows 8 development ecosystem. Then, through a series of example driven chapters, you'll discover how to leverage the platform's unique features. With each project, you'll be one step closer to building full-featured, responsive, and well designed apps that feel like they're a part of the operating system. Windows 8 App Projects - XAML and C# Edit

  16. Cannabis Mobile Apps: A Content Analysis

    OpenAIRE

    Ramo, Danielle E; Popova, Lucy; Grana, Rachel; Zhao, Shirley; Chavez, Kathryn

    2015-01-01

    Background Mobile technology is pervasive and widely used to obtain information about drugs such as cannabis, especially in a climate of rapidly changing cannabis policy; yet the content of available cannabis apps is largely unknown. Understanding the resources available to those searching for cannabis apps will clarify how this technology is being used to reflect and influence cannabis use behavior. Objective We investigated the content of 59 cannabis-related mobile apps for Apple and Androi...

  17. Storybook app creation demystified a cast study

    CERN Document Server

    Friedlander, Amy

    2013-01-01

    This case study explains how Wasabi Productions created its first app, Lazy Larry Lizard, and provides insight into the development of soon-to-be-released app, Gorilla Band. Inside, you will find notes on how storybook apps are produced from start to finish, including costs, production process, people, technology, pricing, release cycle, marketing and more. You will also find insights on technology, storyboard development and pricing.

  18. Medical apps in need of optical microspectrometers

    OpenAIRE

    Wolffenbuttel, R. F.; Wolffenbuttel Hosli, T.M.

    2016-01-01

    Apps have been used for providing additional user functionality on demand to the smartphone. Several highly promising medical apps have been introduced that rely on the build-in camera. However, some of these apps fall short of the expectations, due to the inherent limitation of the camera to operation in the visible spectral range. The more detailed spectral information that an optical microspectrometer can offer is needed. Although CMOS-compatible MEMS technologies enable the on-chip integr...

  19. Dynamics of oligodendrocyte responses to anterograde axonal (Wallerian) and terminal degeneration in normal and TNF-transgenic mice

    DEFF Research Database (Denmark)

    Drøjdahl, Nina; Fenger, Christina; Nielsen, Helle H;

    2004-01-01

    larger levels in the TNF-transgenics. At 5 days after axonal transection, numbers of oligodendrocytes and myelin basic protein (MBP) mRNA expression in the denervated dentate gyrus in TNF-transgenic mice had increased to the same extent as in nontransgenic littermates. At this time, transgenics showed......The inflammatory cytokine tumour necrosis factor (TNF) can both induce oligodendrocyte and myelin pathology and promote proliferation of oligodendrocyte progenitor cells and remyelination. We have compared the response of the oligodendrocyte lineage to anterograde axonal (Wallerian) and terminal...

  20. CSS for Windows 8 app development

    CERN Document Server

    Foster, Jeremy

    2013-01-01

    CSS for Windows 8 App Development is your learning guide for CSS - the language of great Windows 8-style apps. Learn the built-in styles that make the built-in controls shine, how to define them, and how to use CSS to give your custom app assets that beautiful Modern UI style. CSS (Cascading Style Sheets) is the clear standard for styling web applications, and with HTML, CSS, and JavaScript now powering apps on Windows 8, it's the clear standard there as well. CSS is a powerful styling and layout language that greatly simplifies the selection of page elements and their visual display, layout,

  1. Building Web Apps for Google TV

    CERN Document Server

    Ferrate, Andres; Lee, Daniels; Ohye, Maile; Carff, Paul; Shen, Shawn; Hines, Steven

    2011-01-01

    By integrating the Web with traditional TV, Google TV offers developers an important new channel for content. But creating apps for Google TV requires learning some new skills-in fact, what you may already know about mobile or desktop web apps isn't entirely applicable. Building Web Apps for Google TV will help you make the transition to Google TV as you learn the tools and techniques necessary to build sophisticated web apps for this platform. This book shows you how Google TV works, how it fits into the web ecosystem, and what the opportunities are for delivering rich content to millions o

  2. ApkCombiner: Combining Multiple Android Apps to Support Inter-App Analysis

    OpenAIRE

    Li, Li; Bartel, Alexandre; Bissyande, Tegawendé François D Assise; Klein, Jacques; Le Traon, Yves

    2015-01-01

    Part 8: Mobile and Cloud Services Security International audience Android apps are made of components which can leak information between one another using the ICC mechanism. With the growing momentum of Android, a number of research contributions have led to tools for the intra-app analysis of Android apps. Unfortunately, these state-of-the-art approaches, and the associated tools, have long left out the security flaws that arise across the boundaries of single apps, in the interaction ...

  3. Electronic Discharge Letter Mobile App

    OpenAIRE

    Lezcano, Leonardo; Triana, Michel; Ternier, Stefaan; Hartkopf, Kathleen; Stieger, Lina; Schroeder, Hanna; Sopka, Sasa; Drachsler, Hendrik; Maher, Bridget; Henn, Patrick; Orrego, Carola; Marcus, Specht

    2014-01-01

    The electronic discharge letter mobile app takes advantage of Near Field Communication (NFC) within the PATIENT project and a related post-doc study. NFC enabled phones to read passive RFID tags, but can also use this short-range wireless technology to exchange (small) messages. NFC in that sense competes with bluetooth. Compared to bluetooth, NFC: ● Requires the devices to be really close (less than 4cm) ● Does not require the devices to pair before communicating We applied the Android Beam ...

  4. A Guide to Help Consumers Choose Apps and Avoid App Overload

    Science.gov (United States)

    Schuster, Ellen; Zimmerman, Lynda

    2014-01-01

    Mobile technology has transformed the way consumers access and use information. The exponential growth of mobile apps makes finding suitable, easy-to-use nutrition and health-related apps challenging. A guide for consumers helps them ask important questions before downloading apps. The guide can be adapted for other Extension disciplines.

  5. ADDITIONAL STREET BERBASIS APP INVENTOR

    Directory of Open Access Journals (Sweden)

    Mohammad Adib Adhi Prabowo

    2013-05-01

    Full Text Available Abstrak Seiring dengan perkembangan sistem operasi android, telah banyak aplikasi yang memanfaatkan fasilitas GPS dan Google Map, seperti untuk mencari rute, mendapatkan peta, mencari lokasi tertentu pada sebuah tempat. Akan tetapi seringkali pengguna perangkat bergerak kesulitan ketika ingin mengetahui beberapa tempat dan lokasi tertentu karena belum ada fasilitas yang menyediakan informasi lokasi suatu tempat. Walaupun ada informasi lokasi pada peta biasanya informasi yang diberikan lokasi tempat berskala besar, misalnya lokasi tempat wisata atau stasiun kereta api. Pengembangan aplikasi untuk skala kecil ini akan memberikan informasi yang dipresentasikan pada google map. Selama ini belum ada yang memberikan sebuah informasi lokasi tempat penting yang berskala kecil. Misalnya informasi lokasi  tambal ban, lokasi warung makan, lokasi laundry, dan lokasi bengkel motor. Oleh karena itu kami mencoba untuk mengembangkan aplikasi additional street berbasis android via App Inventor dengan bantuan google maps. Aplikasi additional street ini dapat memberikan informasi letak objek pada peta serta memberikan informasi jalan menuju lokasi tersebut dan detail informasi lokasi tersebut serta lokasi dari pengguna aplikasi tersebut. Kata Kunci: additional street, android, google maps, app inventor, GPS

  6. Axonal accumulation of synaptic markers in APP transgenic Drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity

    DEFF Research Database (Denmark)

    Rusu, Patricia; Jansen, Anna; Soba, Peter;

    2007-01-01

    neurotransmission at the neuromuscular junction in transgenic larvae that express human APP. Consistent with the observation that these larvae do not show any obvious movement deficits, we found no changes in basal synaptic transmission. However, short-term synaptic plasticity was affected by overexpression of APP....... Together, our results show that overexpression of APP induces partial stalling of axonal transport vesicles, paralleled by abnormalities in synaptic plasticity, which may provide a functional link to the deterioration of cognitive functions observed in AD....

  7. Gebruikersdata bij abonnementen in app stores

    NARCIS (Netherlands)

    Roosendaal, A.P.C.; Nieuwenhuis, O.A.

    2013-01-01

    Kranten en tijdschriften bieden tegenwoordig vaak, naast de papieren edities, digitale abonnementen aan. De content wordt in dat geval via een app gelezen op een mobiele device, zoals een smartphone of tablet. Om abonnementen in deze vorm aan te kunnen bieden is het bouwen van een app noodzakelijk.

  8. Smartphone-apps som nyt psykiatrisk behandlingstiltag

    DEFF Research Database (Denmark)

    Dalum, Anette Ellegaard; Arnfred, Sidse

    2014-01-01

    The number of smartphone apps for people with mental health issues is undergoing a dramatical growth in these years. We review the available literature on the topic, discuss opportunities and theoretical considerations using smartphone apps in psychiatric treatment and provide an overview...

  9. Smartphone apps as a new psychiatric treatment

    DEFF Research Database (Denmark)

    Dalum, Anette Ellegaard; Arnfred, Sidse Marie

    2014-01-01

    Søg 1 - 1 ud af 1 Smartphone apps as a new psychiatric treatment. Anette Ellegaard Dalum, Sidse Arnfred, 2014, vol. 176, nummer 34, 2014. Ugeskrift for laeger Artikel Importer Fjern......Søg 1 - 1 ud af 1 Smartphone apps as a new psychiatric treatment. Anette Ellegaard Dalum, Sidse Arnfred, 2014, vol. 176, nummer 34, 2014. Ugeskrift for laeger Artikel Importer Fjern...

  10. Is There an App for that?

    Science.gov (United States)

    Douglas, Karen H.; Wojcik, Brian W.; Thompson, James R.

    2012-01-01

    Everyday technologies (e.g., iPods, iPads, and Smart Phones) other applications (apps) that can serve as supports to students with intellectual and related developmental disabilities. The extent to which apps that are currently on the market are aligned with the support needs of children was evaluated using the subscale framework of the…

  11. The Electronic Discharge Letter Mobile App

    NARCIS (Netherlands)

    Lezcano, Leonardo; Ternier, Stefaan; Drachsler, Hendrik; Kalz, Marco; Specht, Marcus

    2013-01-01

    Lezcano, L., Ternier, S., Drachsler, H., Kalz, M., & Specht, M. (2013, September). The Electronic Discharge Letter Mobile App. In iProceedings of MEDICINE 2.0: 6th World Congress on Social Media, Mobile Apps, Internet/Web 2.0 (pp. 221-222). London, England. Retrieved from http://www.medicine20congre

  12. Will HTML5 Kill the Native App?

    Science.gov (United States)

    Fredette, Michelle

    2013-01-01

    For colleges and universities today, the question is no longer whether to develop a campus app or not. Instead, the debate has shifted to the best--and most cost-efficient--way to make campus applications accessible to the myriad devices and operating systems out there. Schools have a few options: They can develop multiple native app versions;…

  13. Design of Trigonometry Apps for Vocational Education

    DEFF Research Database (Denmark)

    Pedersen, Jens Bjarke; Andersen, Steffen; Majgaard, Gunver

    2012-01-01

    How can smartphones apps enrich the learning of mathematicsin vocational education? This article examines how mathematics teaching can be enriched by apps using smartphone sensors such as gyroscope, compass, camera, and touch screen in a aming context. An iterative and participatory design process...

  14. Fra app'ernes planet til klasserummet

    DEFF Research Database (Denmark)

    Falkesgaard Slot, Marie; Gissel, Stig Toke; Lorentzen, Rasmus Fink;

    2013-01-01

    Artiklen udpeger en række kategorier og begreber, som læreren kan anvende i sit arbejde med at analysere og vurdere hvilke handle- og betydningsmuligheder, der er indbygget i hhv. funktionelle, didaktiske og semantiske apps. Med afsæt i disse begreber gives praksisnære bud på, hvordan apps på for...

  15. Cell biology apps for Apple devices.

    Science.gov (United States)

    Stark, Louisa A

    2012-01-01

    Apps for touch-pad devices hold promise for guiding and supporting learning. Students may use them in the classroom or on their own for didactic instruction, just-in-time learning, or review. Since Apple touch-pad devices (i.e., iPad and iPhone) have a substantial share of the touch-pad device market (Campbell, 2012), this Feature will explore cell biology apps available from the App Store. My review includes iPad and iPhone apps available in June 2012, but does not include courses, lectures, podcasts, audiobooks, texts, or other books. I rated each app on a five-point scale (1 star = lowest; 5 stars = highest) for educational and production values; I also provide an overall score. PMID:22949420

  16. Smart apps for the smart plastic surgeon

    Directory of Open Access Journals (Sweden)

    Aniketh Venkataram

    2015-01-01

    Full Text Available Smartphones have the ability to benefit plastic surgeons in all aspects of patient care and education. With the sheer number of applications available and more being created everyday, it is easy to miss out on apps which could be of great relevance. Moreover, the range of android applications available has not been extensively discussed in the literature. To this end, we have compiled an exhaustive list of android smartphone applications, which we feel can help our day to day functioning. The apps have been extensively reviewed and neatly described along with all their potential uses. In addition, we have made an effort to highlight ′non-medical′ or efficiency apps which can improve departmental functioning. These apps have not been described in prior articles, and their functionality might not be known to all. We believe that the technology savvy plastic surgeon can make maximum use of these apps to his benefit.

  17. Best book on marketing your Android app

    CERN Document Server

    Kim, Eddie

    2012-01-01

    Bestselling Android Dev Eddie Kim Teaches You How To Market Your Android Apps! You've designed the perfect app, and you're wondering why no one is buying it. Our experienced Android developer, Eddie Kim, has been in your shoes, and he knows how stiff the competition can be. Eddie introduces you to the people with the power, your customers, as he walks you through the marketing steps you need to take to make your app stand out from the a sea of similar apps. You're an innovative developer, but when it comes to advertising your app, you don't know how to rally an audience like Billy May

  18. Cell biology apps for Apple devices.

    Science.gov (United States)

    Stark, Louisa A

    2012-01-01

    Apps for touch-pad devices hold promise for guiding and supporting learning. Students may use them in the classroom or on their own for didactic instruction, just-in-time learning, or review. Since Apple touch-pad devices (i.e., iPad and iPhone) have a substantial share of the touch-pad device market (Campbell, 2012), this Feature will explore cell biology apps available from the App Store. My review includes iPad and iPhone apps available in June 2012, but does not include courses, lectures, podcasts, audiobooks, texts, or other books. I rated each app on a five-point scale (1 star = lowest; 5 stars = highest) for educational and production values; I also provide an overall score.

  19. App Store的经济学

    Institute of Scientific and Technical Information of China (English)

    姜奇平

    2011-01-01

    App Store由苹果首先推出,App一语双关,在英文中,它既是“苹果”的前三个字母,又是“应用”的前三个字母。将来,App Store是不是专属于苹果还不确定,但有一点可以确定,App Store模式现在已经属于大家了。

  20. Pro JavaScript for web apps

    CERN Document Server

    Freeman, Adam

    2012-01-01

    JavaScript is the engine behind every web app, and a solid knowledge of it is essential for all modern web developers. Pro JavaScript for Web Apps gives you all of the information that you need to create professional, optimized, and efficient JavaScript applications that will run across all devices. It takes you through all aspects of modern JavaScript application creation, showing you how to combine JavaScript with the new features of HTML5 and CSS3 to make the most of the new web technologies. The focus of the book is on creating professional web applications, ensuring that your app provides

  1. Creating mobile apps with Appcelerator Titanium

    CERN Document Server

    Brousseau, Christian

    2013-01-01

    Creating Mobile Apps with Appcelerator Titanium provides a hands-on approach and working examples on creating apps and games as well as embedding them onto a social networking website. Developers can then move on from there to develop their own applications based on the ones they have developed throughout the course of this book.""Creating Mobile Apps with Appcelerator Titanium"" is for developers who have experience with modern languages and development environments. Also, if you are familiar with the concepts of Object-oriented Programming (OOP), reusable components, AJAX closures, and so on

  2. Data Exchanges in Mobile News Apps

    DEFF Research Database (Denmark)

    Kammer, Aske; Wallberg, Filip

    2016-01-01

    This paper maps the flows of data to and from third-party actors when users access content in mobile news apps. This way, it analyzes the strategic networks of collaboration and data exchange that news organizations engage in in the digital economy, expanding the traditional two-sided model...... data from the app use. It compares central news apps across six Western democracies (Denmark, Germany, Italy, Portugal, the UK, and the USA) in order to examine whether media-systemic features (Hallin & Mancini, 2004) and privacy legislation influences data exchanges....

  3. Pro Windows Server AppFabric

    CERN Document Server

    Kaufman, S

    2010-01-01

    This book will teach all about Windows Server AppFabric (code-named "Dublin"),a set of extensions to Windows Server that allow it to function as a lightweight, application server. The combination of Windows Server and AppFabric provides an easy-to-manage platform for developing, deploying, and reliably hosting middle-tier WCF/WF services. Windows Server AppFabric fills an important vacuum left in the wake of COM and COM+'s demise as the .NET platform has risen to prominence. Provided as an extension to Internet Information Services (IIS), the built-in application server frees you fro

  4. Patterns of Direct Projections from the Hippocampus to the Medial Septum-Diagonal Band Complex : Anterograde Tracing with Phaseolus vulgaris Leucoagglutinin Combined with Immunohistochemistry of Choline Acetyltransferase

    NARCIS (Netherlands)

    Gaykema, R.P.A.; Kuil, J. van der; Hersh, L.B.; Luiten, P.G.M.

    1991-01-01

    The projections from the Ammon's horn to the cholinergic cell groups in the medial septal and diagonal band nuclei were investigated with anterograde tracing of Phaseolus vulgaris leucoagglutinin combined with immunocytochemical detection of choline acetyltransferase, in the rat. Tracer injections w

  5. NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease.

    Science.gov (United States)

    Triaca, Viviana; Sposato, Valentina; Bolasco, Giulia; Ciotti, Maria Teresa; Pelicci, Piergiuseppe; Bruni, Amalia C; Cupidi, Chiara; Maletta, Raffaele; Feligioni, Marco; Nisticò, Robert; Canu, Nadia; Calissano, Pietro

    2016-08-01

    NGF has been implicated in forebrain neuroprotection from amyloidogenesis and Alzheimer's disease (AD). However, the underlying molecular mechanisms are still poorly understood. Here, we investigated the role of NGF signalling in the metabolism of amyloid precursor protein (APP) in forebrain neurons using primary cultures of septal neurons and acute septo-hippocampal brain slices. In this study, we show that NGF controls the basal level of APP phosphorylation at Thr668 (T668) by downregulating the activity of the Ser/Thr kinase JNK(p54) through the Tyr kinase signalling adaptor SH2-containing sequence C (ShcC). We also found that the specific NGF receptor, Tyr kinase A (TrkA), which is known to bind to APP, fails to interact with the fraction of APP molecules phosphorylated at T668 (APP(pT668) ). Accordingly, the amount of TrkA bound to APP is significantly reduced in the hippocampus of ShcC KO mice and of patients with AD in which elevated APP(pT668) levels are detected. NGF promotes TrkA binding to APP and APP trafficking to the Golgi, where APP-BACE interaction is hindered, finally resulting in reduced generation of sAPPβ, CTFβ and amyloid-beta (1-42). These results demonstrate that NGF signalling directly controls basal APP phosphorylation, subcellular localization and BACE cleavage, and pave the way for novel approaches specifically targeting ShcC signalling and/or the APP-TrkA interaction in AD therapy. PMID:27076121

  6. Systemic or intra-amygdala infusion of an endocannabinoid CB1 receptor antagonist AM251 blocked propofol-induced anterograde amnesia.

    Science.gov (United States)

    Ren, Y; Wang, J; Xu, P B; Xu, Y J; Miao, C H

    2015-01-01

    Propofol is well-known for its anterograde amnesic actions. However, a recent experiment showed that propofol can also produce retrograde memory enhancement effects via an interaction with the endocannabinoid CB1 system. Therefore, the authors hypothesized that the regulating effect of propofol on the endocannabinoid CB1 system might also decrease the anterograde amnesic effect of propofol under some conditions, which might be a risk factor for intraoperative awareness. Since, the basolateral amygdala (BLA) has been confirmed to mediate propofol-induced anterograde amnesia and the BLA contains a high concentration of CB1 receptors, the authors investigated whether and how the endocannabinoid system, particularly the CB1 receptor within BLA, influences propofol-induced anterograde amnesia. Male Sprague-Dawley rats trained with inhibitory avoidance (IA) were systematically pre-trained using a memory-impairing dose of propofol (25 mg/kg). Before propofol administration, rats received an intraperitoneal injection of a CB1 receptor antagonist AM251 (1 mg/kg or 2 mg/kg) or a bilateral intra-BLA injection of AM251 (0.6 ng or 6 ng per 0.5 μl). Twenty-four hours after IA training, the IA retention latency was tested. It was found that systemic or intra-BLA injection of a non-regulating dose of AM251 (2 mg/kg or 6 ng per 0.5 μl, respectively) blocked the memory-impairing effect of propofol. These results indicate that the anterograde amnesic effect of propofol is mediated, in part, by activation of the CB1 cannabinoid receptors in the BLA.

  7. iOS app development for dummies

    CERN Document Server

    Feiler, Jesse

    2014-01-01

    If you've got incredible iOS ideas, get this book and bring them to life! iOS 7 represents the most significant update to Apple's mobile operating system since the first iPhone was released, and even the most seasoned app developers are looking for information on how to take advantage of the latest iOS 7 features in their app designs. That's where iOS App Development For Dummies comes in! Whether you're a programming hobbyist wanting to build an app for fun or a professional developer looking to expand into the iOS market, this book will walk you through the fundamentals of building a univer

  8. From analogue to apps--developing an app to prepare children for medical imaging procedures.

    Science.gov (United States)

    Williams, Gigi; Greene, Siobhan

    2015-01-01

    The Royal Children's Hospital (RCH) in Melbourne has launched a world-first app for children that will help reduce anxiety and the need for anesthesia during medical imaging procedures. The free, game-based app, "Okee in Medical Imaging", helps children aged from four to eight years to prepare for all medical imaging procedures--X-ray, CT, MRI, ultrasound, nuclear medicine, and fluoroscopy. The app is designed to reduce anticipatory fear of imaging procedures, while helping to ensure that children attend imaging appointments equipped with the skills required for efficient and effective scans to be performed. This paper describes how the app was developed. PMID:26828544

  9. The role of information technology (apps) in FPMRS.

    Science.gov (United States)

    Gonka, Jacquelyn; Kim, Jason

    2015-02-01

    The objective of this study is to provide a comprehensive overview of the use of smartphone "apps" within the field of female pelvic medicine and reconstructive surgery (FPMRS) and the role they play in improving patient education. The authors conducted a keyword search using the search tab in the Apple App Store. The apps selected were ones that specifically pertained to female pelvic medicine. A total of 13 apps were found. The apps were separated into three categories: patient education (five apps), wellness (four apps), and reference (four apps). The majority of the patient education apps consisted of anatomical diagrams of the pelvis and anatomy videos to help explain the pathophysiology behind different pelvic and voiding disorders. Female pelvic medicine apps have a large focus on patient education, which can help patients achieve a greater understanding of female pelvic disorders and the treatment options that are available. PMID:25630917

  10. Mobile Cloud Forensics: An Analysis of Seven Popular Android Apps

    OpenAIRE

    Martini, Ben; Do, Quang; Choo, Kim-Kwang Raymond

    2015-01-01

    Using the evidence collection and analysis methodology for Android devices proposed by Martini, Do and Choo, we examined and analyzed seven popular Android cloud-based apps. Firstly, we analyzed each app in order to see what information could be obtained from their private app storage and SD card directories. We collated the information and used it to aid our investigation of each app database files and AccountManager data. To complete our understanding of the forensic artefacts stored by app...

  11. The Top Chinese Mobile Health Apps: A Systematic Investigation

    Science.gov (United States)

    Hsu, Jeffrey; Liu, Di; Yu, Ya Min; Zhao, Hui Tong; Chen, Zhi Rou; Li, Jiao

    2016-01-01

    Background China’s mHealth market is on track to become a global leader by industry size. The Chinese mobile app market and health care system have peculiarities that distinguish them from other app markets. To date, Chinese mHealth apps have not been systematically investigated. Objective The objective of this study was to provide an overview of Chinese mHealth apps as of December 2015. Methods We identified and investigated the most downloaded apps from the iOS and Android platforms. For each app, we analyzed and recorded its main service offered, mHealth initiative, disease and specialty focus, app cost, target user, Web app availability, and emphasis on information security. Standard descriptive statistics were used. Results A total of 234 apps met the inclusion criteria and were investigated. The apps targeting nonhealth care professionals focused on providing telemedicine and appointment-making services. The apps targeting health care professionals focused on education and peer reviewed articles. The most common disease-specific apps focused primarily on diabetes, hypertension, and hepatitis management. Most apps were free and available on both iOS and Android platforms. Conclusions The primary mHealth initiatives targeted by the apps reflect Chinese patients’ demand for access to medical care. Disease-specific apps are also representative of disease prevalence in China. Government press releases suggest that new policies on the horizon may shift the industry. PMID:27573724

  12. Apps as Artefacts: Towards a Critical Perspective on Mobile Health and Medical Apps

    Directory of Open Access Journals (Sweden)

    Deborah Lupton

    2014-10-01

    Full Text Available Although over 100,000 health and medical mobile apps have been placed on the market, few critical social analyses have been yet undertaken of the role of these apps in healthcare, preventive health and health promotion. In this article I present an argument for approaching the study of mobile apps as sociocultural artefacts, focusing specifically on those that have been developed on health and medical topics. This perspective acknowledges that apps are digital objects that are the products of human decision-making, underpinned by tacit assumptions, norms and discourses already circulating in the social and cultural contexts in which they are generated, marketed and used. First, I provide the context, by discussing the gradual digitisation of health and medical information since the advent of the Internet and the emergence of health and medical apps as one of the latest developments. Second, I discuss how a critical perspective may be employed to analyse the social, cultural and political dimensions of health and medical apps. Finally I illustrate how such an approach may be applied by giving a case study of an analysis of the top 10 ranked health and medical apps on the Apple App Store on one day, outlining some major themes and discourses that emerge.

  13. CERN Apps meet in a forum

    CERN Multimedia

    Antonella Del Rosso

    2013-01-01

    In the fast-evolving world of mobile apps, creativity and usability are key words. For the time being, the number of CERN apps is quite limited but the situation could quickly change. An information-sharing forum set up by the IT Department is a starting point to channel your creativity with the help of experts, best practices and useful guidelines.   The CAPPS (CERN Apps) Forum was set up about a year ago. Its members come from various departments and meet every two or three months to update each other on the apps that are in preparation, share the latest news on the available software, discuss best practices and so on. “The Forum is open to anybody wanting to develop apps at CERN,” explains David Foster, Deputy Department Head and initiator of the CAPPS Forum. “Developers, communication experts and IT infrastructure experts meet and discuss various topics, from branding-related issues to coding and implementation solutions. The aim is to go forward in a coherent way...

  14. Beebook: light field mapping app

    Science.gov (United States)

    De Donatis, Mauro; Di Pietro, Gianfranco; Rinnone, Fabio

    2014-05-01

    In the last decade the mobile systems for field digital mapping were developed (see Wikipedia for "Digital geologic mapping"), also against many skeptic traditional geologists. Until now, hardware was often heavy (tablet PC) and software sometime difficult also for expert GIS users. At present, the advent of light tablet and applications makes things easier, but we are far to find a whole solution for a complex survey like the geological one where you have to manage complexities such information, hypothesis, data, interpretation. Beebook is a new app for Android devices, has been developed for fast ad easy mapping work in the field trying to try to solve this problem. The main features are: • off-line raster management, GeoTIFF ed other raster format using; • on-line map visualisation (Google Maps, OSM, WMS, WFS); • SR management and conversion using PROJ.4; • vector file mash-up (KML and SQLite format); • editing of vector data on the map (lines, points, polygons); • augmented reality using "Mixare" platform; • export of vector data in KML, CSV, SQLite (Spatialite) format; • note: GPS or manual point inserting linked to other application files (pictures, spreadsheet, etc.); • form: creation, edition and filling of customized form; • GPS: status control, tracker and positioning on map; • sharing: synchronization and sharing of data, forms, positioning and other information can be done among users. The input methods are different from digital keyboard to fingers touch, from voice recording to stylus. In particular the most efficient way of inserting information is the stylus (or pen): field geologists are familiar with annotation and sketches. Therefore we suggest the use of devices with stylus. The main point is that Beebook is the first "transparent" mobile GIS for tablet and smartphone deriving from previous experience as traditional mapping and different previous digital mapping software ideation and development (MapIT, BeeGIS, Geopaparazzi

  15. The Business of iPhone App Development

    CERN Document Server

    Wooldridge, Dave

    2010-01-01

    The phenomenal success of the iPhone and the iPod touch has ushered in a "gold rush" for developers, but with well over 100,000 apps in the highly competitive App Store, it has become increasingly difficult for new apps to stand out in the crowd. Achieving consumer awareness and sales longevity for your iPhone app requires a lot of organization and some strategic planning. This book will show you how to incorporate marketing and business savvy into every aspect of the design and development process, giving your app the best possible chance of succeeding in the App Store. The Business

  16. iOS app development portable genius

    CERN Document Server

    Wentk, Richard

    2012-01-01

    The essential skills and technologies needed for iOS development in one handy guide! The unprecedented popularity of iOS devices, such as the iPhone, iPad, and iPod touch, has led to a development boom. If you’re eager to become part of the action, then this is the book for you! Packed with must-have information on iOS development, this handy guide covers Objective-C, Xcode, Frameworks, and sound design principles and explains how to upload an app to the app store and integrate apps with the latest advances that Apple offers developers. The featured tips and tricks will get you up and ru

  17. The "Free from Housing Accessibility Problems" App.

    Science.gov (United States)

    Jonsson, Oskar; Slaug, Björn; Haak, Maria; Mårtensson, Knut; Schmidt, Steven M; Oswald, Frank; Rimland, Joseph M; Tomsone, Signe; Svensson, Torbjörn; Iwarsson, Susanne

    2016-01-01

    The present study concerns the development of a computerized tool targeting housing accessibility issues. A user-centered approach involving professionals from the housing sector and senior citizens from four European countries resulted in a fully functional prototype of a mobile application (app) including an apartment database. The app raises awareness on housing accessibility and has the potential to support decision making and strengthen all citizens regardless of functional capacity to be more active in their endeavors for a satisfying housing solution. Further refinements and additional features are needed to enhance the potential benefits; they include addressing potential challenges facing senior citizens, developing interactive features that allow users to provide input and adapting to different national contexts to make the app applicable for the European market. PMID:27534351

  18. APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain

    OpenAIRE

    Chen, Yuzhi; Liu,Wenyun; McPhie, Donna L.; Hassinger, Linda; Neve, Rachael L

    2003-01-01

    APP-BP1, first identified as an amyloid precursor protein (APP) binding protein, is the regulatory subunit of the activating enzyme for the small ubiquitin-like protein NEDD8. We have shown that APP-BP1 drives the S- to M-phase transition in dividing cells, and causes apoptosis in neurons (Chen, Y., D.L. McPhie, J. Hirschberg, and R.L. Neve. 2000. J. Biol. Chem. 275:8929–8935). We now demonstrate that APP-BP1 binds to the COOH-terminal 31 amino acids of APP (C31) and colocalizes with APP in a...

  19. Web Content Flexibility through Mobile App

    OpenAIRE

    Sana Pathan; Rajeshri Khairnar

    2014-01-01

    E-commerce is very efficient & effective, but it needs programming knowledge to manage.many small organizations do not have human resource for this task and cannot support cost for hiring programmers or tech-support.thus, many applications providers create CMS apps to enable the e-commerce website to be created and with friendly UI. By developing iOS app WCFMA, it can handle this dynamic nature of content manipulation. WCFMA is specifically designed to enable non-technical users,to modify the...

  20. Tapworthy Designing Great iPhone Apps

    CERN Document Server

    Clark, Josh

    2010-01-01

    So you've got an idea for an iPhone app -- along with everyone else on the planet. Set your app apart with elegant design, efficient usability, and a healthy dose of personality. This accessible, well-written guide shows you how to design exceptional user experiences for the iPhone and iPod Touch through practical principles and a rich collection of visual examples. Whether you're a designer, programmer, manager, or marketer, Tapworthy teaches you to "think iPhone" and helps you ask the right questions -- and get the right answers -- throughout the design process. You'll explore how consider

  1. Better Lung Cancer Survival? There's an App for That

    Science.gov (United States)

    ... nih.gov/medlineplus/news/fullstory_159289.html Better Lung Cancer Survival? There's an App for That Study found ... HealthDay News) -- A new smartphone app may help lung cancer patients live longer and better by monitoring their ...

  2. Better Lung Cancer Survival? There's an App for That

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_159289.html Better Lung Cancer Survival? There's an App for That Study found ... HealthDay News) -- A new smartphone app may help lung cancer patients live longer and better by monitoring their ...

  3. Review of Tour of the Nile [iPad App

    Directory of Open Access Journals (Sweden)

    Helen Strudwick

    2013-07-01

    Full Text Available A review of the iPad app, Tour of the Nile. The app promises 'a virtual journey along the Nile Valley' plus the chance to 'handle' objects through the technology of augmented reality.

  4. THELMA: a mobile app for crowdsourcing environmental data

    Science.gov (United States)

    Hintz, Kenneth J.; Hintz, Christopher J.; Almomen, Faris; Adounvo, Christian; D'Amato, Michael

    2014-06-01

    The collection of environmental light pollution data related to sea turtle nesting sites is a laborious and time consuming effort entailing the use of several pieces of measurement equipment, their transportation and calibration, the manual logging of results in the field, and subsequent transfer of the data to a computer for post-collection analysis. Serendipitously, the current generation of mobile smart phones (e.g., iPhone® 5) contains the requisite measurement capability, namely location data in aided GPS coordinates, magnetic compass heading, and elevation at the time an image is taken, image parameter data, and the image itself. The Turtle Habitat Environmental Light Measurement App (THELMA) is a mobile phone app whose graphical user interface (GUI) guides an untrained user through the image acquisition process in order to capture 360° of images with pointing guidance. It subsequently uploads the user-tagged images, all of the associated image parameters, and position, azimuth, elevation metadata to a central internet repository. Provision is also made for the capture of calibration images and the review of images before upload. THELMA allows for inexpensive, highly-efficient, worldwide crowdsourcing of calibratable beachfront lighting/light pollution data collected by untrained volunteers. This data can be later processed, analyzed, and used by scientists conducting sea turtle conservation in order to identify beach locations with hazardous levels of light pollution that may alter sea turtle behavior and necessitate human intervention after hatchling emergence.

  5. Creating iPhone Apps with Cocoa Touch

    CERN Document Server

    Hockenberry, Craig

    2010-01-01

    Creating iPhone Apps with Cocoa Touch: The Mini Missing Manual walks you through developing your first iPhone App and introduces you to your programming environments and tools: Cocoa Touch, Interface Builder, Xcode, and the Objective-C programming language. If you're a Java or C developer, this eBook is your fast track to App development. This eBook is adapted from parts of iPhone App Development: The Missing Manual.

  6. Just a Fad? Gamification in Health and Fitness Apps

    OpenAIRE

    Lister, Cameron; West, Josh; Cannon, Ben; Sax, Tyler; Brodegard, David

    2014-01-01

    Background Gamification has been a predominant focus of the health app industry in recent years. However, to our knowledge, there has yet to be a review of gamification elements in relation to health behavior constructs, or insight into the true proliferation of gamification in health apps. Objective The objective of this study was to identify the extent to which gamification is used in health apps, and analyze gamification of health and fitness apps as a potential component of influence on a...

  7. A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion.

    Directory of Open Access Journals (Sweden)

    Magdalena L Circu

    Full Text Available Lysosome trafficking plays a significant role in tumor invasion, a key event for the development of metastasis. Previous studies from our laboratory have demonstrated that the anterograde (outward movement of lysosomes to the cell surface in response to certain tumor microenvironment stimulus, such as hepatocyte growth factor (HGF or acidic extracellular pH (pHe, increases cathepsin B secretion and tumor cell invasion. Anterograde lysosome trafficking depends on sodium-proton exchanger activity and can be reversed by blocking these ion pumps with Troglitazone or EIPA. Since these drugs cannot be advanced into the clinic due to toxicity, we have designed a high-content assay to discover drugs that block peripheral lysosome trafficking with the goal of identifying novel drugs that inhibit tumor cell invasion. An automated high-content imaging system (Cellomics was used to measure the position of lysosomes relative to the nucleus. Among a total of 2210 repurposed and natural product drugs screened, 18 "hits" were identified. One of the compounds identified as an anterograde lysosome trafficking inhibitor was niclosamide, a marketed human anti-helminthic drug. Further studies revealed that niclosamide blocked acidic pHe, HGF, and epidermal growth factor (EGF-induced anterograde lysosome redistribution, protease secretion, motility, and invasion of DU145 castrate resistant prostate cancer cells at clinically relevant concentrations. In an effort to identify the mechanism by which niclosamide prevented anterograde lysosome movement, we found that this drug exhibited no significant effect on the level of ATP, microtubules or actin filaments, and had minimal effect on the PI3K and MAPK pathways. Niclosamide collapsed intralysosomal pH without disruption of the lysosome membrane, while bafilomycin, an agent that impairs lysosome acidification, was also found to induce JLA in our model. Taken together, these data suggest that niclosamide promotes

  8. Technology Corner: A Regular Expression Training App

    Directory of Open Access Journals (Sweden)

    Nick Flor

    2012-12-01

    Full Text Available Regular expressions enable digital forensic analysts to find information in files. The best way for an analyst to become proficient in writing regular expressions is to practice. This paper presents the code for an app that allows an analyst to practice writing regular expressions.

  9. Fra app'ernes planet til klasserummet

    DEFF Research Database (Denmark)

    Slot, Marie Falkesgaard; Bundsgaard, Jeppe; Gissel, Stig Toke;

    2013-01-01

    Artiklen henvender sig til lærere og konsulenter, som ønsker at kvalificere deres fagsprog i arbejdet med apps og undervisningsdesign. Med udgangspunkt i læremiddeldidaktikken udpeger vi en række kategorier og begreber, som læreren kan anvende i sit arbejde med at analysere og vurdere hvilke hand...

  10. Fra app'ernes planet til klasserummet

    DEFF Research Database (Denmark)

    Hansen, Thomas Illum; Slot, Marie Falkesgaard; Gissel, Stig Toke;

    2013-01-01

    Artiklen henvender sig til lærere og konsulenter, som ønsker at kvalificere deres fagsprog i arbejdet med apps og undervisningsdesign. Med udgangspunkt i læremiddeldidaktikken udpeges en række kategorier og begreber, som læreren kan anvende i sit arbejde med at analyserer og vurderer hvilke handl...

  11. Smart phones and apps application in dermatology

    Directory of Open Access Journals (Sweden)

    Meltem Önder

    2013-03-01

    Full Text Available Mobile phones are a device that is more than just a phone and more than a personel digital assistant.Nowadays a phone is as a powerful handheld computer,camera,video recorder,media player,GPS receiver,MP3 player,radio and as well as a communication tool. Smartphones (mobile phones with advanced computing capability are rapidly gaining new use with the advent of dowloadable applications known as ‘Apps’. There are a lot of medical apps avaliable.Dermatology themed smartphone apps were provided as reference materials,illustrated databases of common skin conditions for accessing online versions of popular dermatology textbook and journals;dermatology based questionnairs; including disease severity scoring calculators and /or providing automated photo analysers for skin lesions / as an electronic dermoscopy. Most of the apps applications are free of charge and can be easily dowloaded to smartphones. Furthermore the possibility to send and save both text and images by this technology seems perfectly tailored to dermatology.Recently electronic teaching and learning via smartphones are becoming very popular for medical students aswell. However there is relatively little research on medical uses and potential roles of them in dermatology.This article summarizes the curent trends in the ‘smartphone market’ and takes a glance at some dermatology apps ‘which are currently available.

  12. Web Content Flexibility through Mobile App

    Directory of Open Access Journals (Sweden)

    Sana Pathan

    2014-03-01

    Full Text Available E-commerce is very efficient & effective, but it needs programming knowledge to manage.many small organizations do not have human resource for this task and cannot support cost for hiring programmers or tech-support.thus, many applications providers create CMS apps to enable the e-commerce website to be created and with friendly UI. By developing iOS app WCFMA, it can handle this dynamic nature of content manipulation. WCFMA is specifically designed to enable non-technical users,to modify the existing contents as and when required in an intuitive and real-time fashion.and instead of downloading or capturing product images to be displayed on websites from separate camera devices,take it from the mobile device(iphone itself and edit the image like never before in the app and once done upload it on the web server. The website will fetch this updated images and display i tat an appropriate location.it will efficiently serve to dynamically manage websites of buisness whitch needs to change their web content at regular intervals where the owner or staff of the organization can handle their website from their iphone app.

  13. Live Speed Analysis, en app til hastighedsmålinger

    DEFF Research Database (Denmark)

    Bolet, Lars; Christensen, Peter Muhlig; Halskov-Sørensen, Asbjørn;

    2013-01-01

    I et bachelorprojekt har tre studerende udviklet en app, som kan registrere og behandle hastigheder ved den såkaldte spejlmetode. App'en er siden videreudviklet, så registreringerne stedfæstes, tidstemples og uploades til en fæIIes database. App'en er frit tilgængelig. Den kan bruges af vejforval...

  14. English Language Teaching Apps: Positioning Parents and Young Learners

    Science.gov (United States)

    Chik, Alice

    2014-01-01

    Since the introduction of iPads in 2010, the sales of tablet computers and mobile applications (apps) have grown exponentially. iPads and other tablets are marketed as learning tools, and many apps target learners as young as six months old. This article reports on a research project examining the unique features of English learning apps based on…

  15. Hippocampal network oscillations in APP/APLP2-deficient mice.

    Directory of Open Access Journals (Sweden)

    Xiaomin Zhang

    Full Text Available The physiological function of amyloid precursor protein (APP and its two homologues APP-like protein 1 (APLP1 and 2 (APLP2 is largely unknown. Previous work suggests that lack of APP or APLP2 impairs synaptic plasticity and spatial learning. There is, however, almost no data on the role of APP or APLP at the network level which forms a critical interface between cellular functions and behavior. We have therefore investigated memory-related synaptic and network functions in hippocampal slices from three lines of transgenic mice: APPsα-KI (mice expressing extracellular fragment of APP, corresponding to the secreted APPsα ectodomain, APLP2-KO, and combined APPsα-KI/APLP2-KO (APPsα-DM for "double mutants". We analyzed two prominent patterns of network activity, gamma oscillations and sharp-wave ripple complexes (SPW-R. Both patterns were generally preserved in all strains. We find, however, a significantly reduced frequency of gamma oscillations in CA3 of APLP2-KO mice in comparison to APPsα-KI and WT mice. Network activity, basic synaptic transmission and short-term plasticity were unaltered in the combined mutants (APPsα-DM which showed, however, reduced long-term potentiation (LTP. Together, our data indicate that APLP2 and the intracellular domain of APP are not essential for coherent activity patterns in the hippocampus, but have subtle effects on synaptic plasticity and fine-tuning of network oscillations.

  16. e-Medication met behulp van apps : Gebruik en gebruikerservaringen

    NARCIS (Netherlands)

    van Kerkhof LWM; van de Laar K; Schooneveldt B; Hegger I; EVG; V& Z

    2015-01-01

    De afgelopen jaren zijn er veel apps voor het gebruik van medicijnen beschikbaar gekomen, voor zowel professionals als burgers. In hoeverre deze apps worden gewaardeerd, hangt vooral af van het gebruiksgemak. Dit blijkt uit onderzoek van het RIVM onder gebruikers van apps die voor diabetici en anest

  17. Educational Behavior Apps and Wearable Devices: Current Research and Prospects

    Science.gov (United States)

    Lowe, Heather

    2016-01-01

    Dartmouth and MIT have developed educational behavior apps and wearable devices that collect contiguous streams of data from student users. Given the consent of the user, the app collects information about a student's physical activity, sleep patterns, and location to form conjectures about social and academic behavior. These apps have the…

  18. Using the Modern Technology That Is the "App"

    Science.gov (United States)

    Bernardelli, Alessio

    2013-01-01

    A few years ago, the sight of the letters APP would have made teachers in England think of the Assessing Pupils' Progress assessment approach introduced by the government. Now, when they see those same letters they mostly think about smartphone and tablet applications, shortened to "apps." With the thousands of apps available in the…

  19. Using Apps to Support Disciplinary Literacy and Science Learning

    Science.gov (United States)

    Castek, Jill; Beach, Richard

    2013-01-01

    Apps, specialized programs used on mobile computers, can be used in innovative ways to enhance science and literacy learning. With the skilled guidance of their teachers, students can exploit app affordances for learning and acquire disciplinary literacies unique to science. This article showcases apps that help students to access information,…

  20. Smartphone apps for orthopaedic sports medicine – a smart move?

    OpenAIRE

    Wong, Seng Juong; Robertson, Greg A.; Connor, Katie L.; Brady, Richard R.; Wood, Alexander M

    2015-01-01

    Background With the advent of smartphones together with their downloadable applications (apps), there is increasing opportunities for doctors, including orthopaedic sports surgeons, to integrate such technology into clinical practice. However, the clinical reliability of these medical apps remains questionable. We reviewed available apps themed specifically towards Orthopaedic Sports Medicine and related conditions and assessed the level of medical professional involvement in their design and...

  1. Design and AppIication of Automatic ControI System in Port PetroIeum Coke Transport%港口石油焦输送自动控制系统设计与应用

    Institute of Scientific and Technical Information of China (English)

    于秀娟; 王世宁

    2014-01-01

    介绍了以PLC为控制核心,综合运用Profibus现场总线、以太网和Modbus现场总线的港口石油焦输送自动控制系统系统设计与应用。 PLC控制和上位监控程序分别在西门子公司的集成开发环境下完成,从系统概述、网络构成、功能设计、程序编制说明、系统配置等几方面论述了该系统。%This paper designs a Port PetroIeum Coke Transport system of automatic controI with PLC controI,combining with Profibus fieIdbus,Ethernet and Modbus fieIdbus.The PLC controI and host monitoring program are deveIoped in the SIEMENS's integrated environment.The contents in the system contain the system overview,network design,functionaI design, programming instructions,system configuration and other aspects.

  2. Different types of spinal afferent nerve endings in stomach and esophagus identified by anterograde tracing from dorsal root ganglia.

    Science.gov (United States)

    Spencer, Nick J; Kyloh, Melinda; Beckett, Elizabeth A; Brookes, Simon; Hibberd, Tim

    2016-10-15

    In visceral organs of mammals, most noxious (painful) stimuli as well as innocuous stimuli are detected by spinal afferent neurons, whose cell bodies lie in dorsal root ganglia (DRGs). One of the major unresolved questions is the location, morphology, and neurochemistry of the nerve endings of spinal afferents that actually detect these stimuli in the viscera. In the upper gastrointestinal (GI) tract, there have been many anterograde tracing studies of vagal afferent endings, but none on spinal afferent endings. Recently, we developed a technique that now provides selective labeling of only spinal afferents. We used this approach to identify spinal afferent nerve endings in the upper GI tract of mice. Animals were anesthetized, and injections of dextran-amine were made into thoracic DRGs (T8-T12). Seven days post surgery, mice were euthanized, and the stomach and esophagus were removed, fixed, and stained for calcitonin gene-related peptide (CGRP). Spinal afferent axons were identified that ramified extensively through many rows of myenteric ganglia and formed nerve endings in discrete anatomical layers. Most commonly, intraganglionic varicose endings (IGVEs) were identified in myenteric ganglia of the stomach and varicose simple-type endings in the circular muscle and mucosa. Less commonly, nerve endings were identified in internodal strands, blood vessels, submucosal ganglia, and longitudinal muscle. In the esophagus, only IGVEs were identified in myenteric ganglia. No intraganglionic lamellar endings (IGLEs) were identified in the stomach or esophagus. We present the first identification of spinal afferent endings in the upper GI tract. Eight distinct types of spinal afferent endings were identified in the stomach, and most of them were CGRP immunoreactive. J. Comp. Neurol. 524:3064-3083, 2016. © 2016 Wiley Periodicals, Inc. PMID:27019197

  3. Anterograde Activin signaling regulates postsynaptic membrane potential and GluRIIA/B abundance at the Drosophila neuromuscular junction.

    Directory of Open Access Journals (Sweden)

    Myung-Jun Kim

    Full Text Available Members of the TGF-β superfamily play numerous roles in nervous system development and function. In Drosophila, retrograde BMP signaling at the neuromuscular junction (NMJ is required presynaptically for proper synapse growth and neurotransmitter release. In this study, we analyzed whether the Activin branch of the TGF-β superfamily also contributes to NMJ development and function. We find that elimination of the Activin/TGF-β type I receptor babo, or its downstream signal transducer smox, does not affect presynaptic NMJ growth or evoked excitatory junctional potentials (EJPs, but instead results in a number of postsynaptic defects including depolarized membrane potential, small size and frequency of miniature excitatory junction potentials (mEJPs, and decreased synaptic densities of the glutamate receptors GluRIIA and B. The majority of the defective smox synaptic phenotypes were rescued by muscle-specific expression of a smox transgene. Furthermore, a mutation in actβ, an Activin-like ligand that is strongly expressed in motor neurons, phenocopies babo and smox loss-of-function alleles. Our results demonstrate that anterograde Activin/TGF-β signaling at the Drosophila NMJ is crucial for achieving normal abundance and localization of several important postsynaptic signaling molecules and for regulating postsynaptic membrane physiology. Together with the well-established presynaptic role of the retrograde BMP signaling, our findings indicate that the two branches of the TGF-β superfamily are differentially deployed on each side of the Drosophila NMJ synapse to regulate distinct aspects of its development and function.

  4. Brainstem projections of neurons located in various subdivisions of the dorsolateral hypothalamic area – an anterograde tract-tracing study

    Directory of Open Access Journals (Sweden)

    Rege Sugárka Papp

    2014-05-01

    Full Text Available The projections from the dorsolateral hypothalamic area (DLH to the lower brainstem have been investigated by using biotinylated dextran amine (BDA, an anterograde tracer in rats. The DLH can be divided into 3 areas (dorsomedial hypothalamus, perifornical area, lateral hypothalamic area, and further subdivided into 8 subdivisions. After unilateral stereotaxic injections of BDA into individual DLH subdivisions, the correct sites of injections were controlled histologically, and the distribution patterns of BDA-positive fibers were mapped on serial sections between the hypothalamus and spinal cord in 22 rats. BDA-labeled fibers were observable over 100 different brainstem areas, nuclei or subdivisions. Injections into the 8 DLH subdivisions established distinct topographical patterns. In general, the density of labeled fibers was low in the lower brainstem. High density of fibers was seen only 4 of the 116 areas: in the lateral and ventrolateral parts of the periaqueductal gray, the Barrington’s and the pedunculopontine tegmental nuclei. All of the biogenic amine cell groups in the lower brainstem (9 noradrenaline, 3 adrenaline and 9 serotonin cell groups received labeled fibers, some of them from all, or at least 7 DLH subdivisions, mainly from perifornical and ventral lateral hypothalamic neurons. Some of the tegmental nuclei and nuclei of the reticular formation were widely innervated, although the density of the BDA-labeled fibers was generally low. No definitive descending BDA-positive pathway, but long-run solitaire BDA-labeled fibers were seen in the lower brainstem. These descending fibers joined some of the large tracts or fasciculi in the brainstem. The distribution pattern of BDA-positive fibers of DLH origin throughout the lower brainstem was comparable to patterns of previously published orexin- or melanin-concentrating hormone-immunoreactive fibers with somewhat differences.

  5. APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons

    Directory of Open Access Journals (Sweden)

    Steven Moore

    2015-05-01

    Full Text Available Accumulation of Aβ peptide fragments of the APP protein and neurofibrillary tangles of the microtubule-associated protein tau are the cellular hallmarks of Alzheimer’s disease (AD. To investigate the relationship between APP metabolism and tau protein levels and phosphorylation, we studied human-stem-cell-derived forebrain neurons with genetic forms of AD, all of which increase the release of pathogenic Aβ peptides. We identified marked increases in intracellular tau in genetic forms of AD that either mutated APP or increased its dosage, suggesting that APP metabolism is coupled to changes in tau proteostasis. Manipulating APP metabolism by β-secretase and γ-secretase inhibition, as well as γ-secretase modulation, results in specific increases and decreases in tau protein levels. These data demonstrate that APP metabolism regulates tau proteostasis and suggest that the relationship between APP processing and tau is not mediated solely through extracellular Aβ signaling to neurons.

  6. The Business of iPhone and iPad App Development Making and Marketing Apps That Succeed

    CERN Document Server

    Wooldridge, Dave

    2011-01-01

    The phenomenal success of the iPhone, iPad and the iPod touch has ushered in a "gold rush" for developers, but with well over 300,000 apps in the highly competitive App Store, it has become increasingly difficult for new apps to stand out in the crowd. Achieving consumer awareness and sales longevity for your iOS app requires a lot of organization and some strategic planning. Updated and expanded for iOS 4, this bestselling book will show you how to incorporate marketing and business savvy into every aspect of the design and development process, giving your app the best possible chance of

  7. The iPhone app design manual create perfect designs for effortless coding and app store success

    CERN Document Server

    Brown, Dave

    2014-01-01

    App creation is now a huge, global business, with hundreds of thousands of developers, entrepreneurs, and companies attracted by the potential rewards. But games, functional apps, and promotional apps alike depend on attractive, intuitive design for their appeal, and most fail to find a significant audience. With this book, you'll be able to turn your great app idea into a functioning design ready for coding, or apply graphic design skills to this exciting new field, and create an app that will stand out in a market that is worth over a billion dollars every year. Understand the design proc

  8. Audio App Brings a Better Nights Sleep

    Science.gov (United States)

    2015-01-01

    Neuroscientist Seth Horowitz was part of a NASA-funded team at State University of New York Stony Brook demonstrating that low-amplitude vestibular stimulation could induce sleep. After recognizing the same stimulation could be applied through sound, Horowitz founded Sleep Genius, located in Park City, Utah, and released a mobile app of the same name that helps people to get a more restful sleep.

  9. Demand modeling for mobile app stores

    OpenAIRE

    Mobarek, Ahmed

    2014-01-01

    Smartphones have reached a relatively high market share of the mobile market, creating new market opportunities. As a result, different stakeholders are investing in the mobile industry attempting to generate a higher revenue share. Hence, competition between various mobile device manufacturers has increased, as they compete for customers. These device manufacturers have created their own ecosystems, trying to lock-in their customers. These ecosystems include the application (app) stores prov...

  10. An interactive app for color deficient viewers

    Science.gov (United States)

    Lau, Cheryl; Perdu, Nicolas; Rodríguez-Pardo, Carlos E.; Süsstrunk, Sabine; Sharma, Gaurav

    2015-01-01

    Color deficient individuals have trouble seeing color contrasts that could be very apparent to individuals with normal color vision. For example, for some color deficient individuals, red and green apples do not have the striking contrast they have for those with normal color vision, or the abundance of red cherries in a tree is not immediately clear due to a lack of perceived contrast. We present a smartphone app that enables color deficient users to visualize such problematic color contrasts in order to help them with daily tasks. The user interacts with the app through the touchscreen. As the user traces a path around the touchscreen, the colors in the image change continuously via a transform that enhances contrasts that are weak or imperceptible for the user under native viewing conditions. Specifically, we propose a transform that shears the data along lines parallel to the dimension corresponding to the affected cone sensitivity of the user. The amount and direction of shear are controlled by the user's finger movement over the touchscreen allowing them to visualize these contrasts. Using the GPU, this simple transformation, consisting of a linear shear and translation, is performed efficiently on each pixel and in real-time with the changing position of the user's finger. The user can use the app to aid daily tasks such as distinguishing between red and green apples or picking out ripe bananas.

  11. No app for that? Make it yourself!

    CERN Multimedia

    CERN Bulletin

    2012-01-01

    Are you passionate about science? Do you like communicating that passion to the general public? Then come along to the very first CERN Summer Student Webfest kicking off on Friday 3 August! The Webfest is a grassroots initiative by the summer students, seeking to spark new ideas that could innovate the future of web-based education about CERN, the LHC and particle physics.   The CERN Summer Student Webfest is a weekend of online web-based creativity modelled on the gatherings (sometimes called hackfests or hackathons) that energize many open source communities. You can work with like-minded students and CERN staff to design and build demos of the web apps you would like to see online. Prizes will be awarded to the best apps, with a Grand Prize winner receiving a trip to the Mozilla Festival in London! Participants in the CERN Summer Student Webfest will work in teams and design neat web apps that encourage the public to learn more about science and, in particular, CERN, the LHC and particle physi...

  12. Development of an IOS App Using Situated Learning, Communities of Practice, and Augmented Reality for Autism Spectrum Disorder

    Science.gov (United States)

    Clarkson, Jessica

    2014-01-01

    This paper presents the development process and framework used to construct a transportation app that uses situated learning, augmented reality, and communities of practice. Autism spectrum disorder (ASD) is a neurodevelopmental disorder that can cause social impairments as well as the limit the potential for the individual to achieve independence…

  13. PoliticAPP: Towards a Categorization of Mobile Apps in Political Communication

    Directory of Open Access Journals (Sweden)

    Pablo VÁZQUEZ SANDE

    2016-06-01

    Full Text Available This article is an analyze of all mobile apps that are available in the field of Spanish political communication, with the aim to develop a pioneering categorization of these platforms according to various criteria as promoters, aims pursued or areas of performance. It includes also a critical review from which it is concluded that these app reproduce classic communication patterns with the voters. That means that the implementation of these channels seems to have been due more to political marketing than to boost democratic participation or to introduce an horizontal outline of a new relationship between politicians and citizens.

  14. In-Application Payment from Mobile Apps: A study of In-App Payment

    OpenAIRE

    Haines, Jøran Christiansen; Hanssen, Alexander

    2013-01-01

    The main purpose of this thesis is to evaluate and compare existing serviceproviders of in-app payment solutions and their APIs, and then concludewhat would be the best choice for hobby developers when deciding on whatservice provider to use for their application.We gained hands-on experience by developing a simple Quiz game appthat featured the implementation of in-app purchase. We took a look atthe major service providers; Apple, Google, PayPal and Windows to getrelevant information and eva...

  15. Engineering stories? A narratological approach to children's book apps

    Directory of Open Access Journals (Sweden)

    Hadassah Stichnothe

    2014-01-01

    Full Text Available With the rise of smartphones and tablet pcs, children's book apps have emerged as a new type of children's media. While some of them are based on popular children's books such as Mo Willems’ Pigeon books or Beatrix Potter's Peter Rabbit, others were specifically designed as apps. This paper focuses on examining book apps under the aspects of implied user strategies and narrative structure. Using a narratological framework that also takes into account the unique characteristics of the medium, a terminology for the analysis of book apps will be sketched out. Furthermore, an exemplary analysis of iOS books apps for pre- and grade school children comes to the conclusion that, far from offering the child users room for individual creativity, a large number of apps rather train their users in following prescribed paths of reading.

  16. mHealth Apps and Their Risks - Taking Stock.

    Science.gov (United States)

    Albrecht, Urs-Vito; von Jan, Ute

    2016-01-01

    Despite the popularity of health related apps and the great potential they hold for improving health care, the risks as well as potential hazards posed by such apps are often not adequately appreciated by users. Based on an analysis of scientific literature as well as anecdotal evidence, this contribution addresses the most common risks and pitfalls of health related apps (e.g. related to physical integrity as well as bodily and mental wellbeing) that users may encounter and sketches some remedies. While certainly not exhaustive, the mentioned aspects may serve as a starting point to raise awareness about potential risks of health related apps. PMID:27350511

  17. Marketing plan for "Twibfy" iOS app

    OpenAIRE

    Timonin, Nikita

    2014-01-01

    The number of mobile apps available in Apple App Store is growing rapidly. To make an application noticeable and successful the publisher needs to have a thorough marketing strategy. The objective of this thesis is to develop a guidance to mobile app marketing, using an iOS app called “Twibfy” as a case study.The marketing plan will be structured according to modern marketing theories.The case is described with a 5C situational analyses system, which includes quantitative analysis based on th...

  18. APP physiological and pathophysiological functions:insights from animal models

    Institute of Scientific and Technical Information of China (English)

    Qinxi Guo; Zilai Wang; Hongmei Li; Mary Wiese; Hui Zheng

    2012-01-01

    The amyloid precursor protein (APP) has been under intensive study in recent years,mainly due to its critical role in the pathogenesis of Alzheimer's disease (AD).β-Amyloid (Aβ) peptides generated from APP proteolytic cleavage can aggregate,leading to plaque formation in human AD brains.Point mutations of APP affecting Aβ production are found to be causal for hereditary early onset familial AD.It is very likely that elucidating the physiological properties of APP will greatly facilitate the understanding of its role in AD pathogenesis.A number of APP loss- and gainof-function models have been established in model organisms including Caenorhabditis elegans,Drosophila,zebrafish and mouse.These in vivo models provide us valuable insights into APP physiological functions.In addition,several knock-in mouse models expressing mutant APP at a physiological level are available to allow us to study AD pathogenesis without APP overexpression.This article will review the current physiological and pathophysiological animal models of APP.

  19. ‘Gamification’ for Health Behaviour Change in Smartphone Apps

    Directory of Open Access Journals (Sweden)

    Elizabeth Ann Edwards

    2015-09-01

    Full Text Available Background: Gamification techniques are showing promise in promoting healthy behaviours and delivering health promotion advice, however, their use in Mobile-Health is relatively new. Gamification involves using ‘gaming’ elements such as badges, leader boards, health-related challenges, rewards, ability to ‘level up’ and use of avatars to motivate and engage people to change health behavior. Gamification techniques may also overlap with validated health behaviour change techniques (BCTs, however, few apps appear to apply the techniques systematically or to define the BCTs they include. Aim: We aimed a to assess the number apps that incorporate gamification to modify health behaviors, b to examine the BCT repertoire and combinations used in these apps c to consider associations with user satisfaction. Methods: English-language health apps that contain gamification techniques were identified through a systematic search of the official Apple and Google Play store and the NHS health apps library. Top rated free and paid Medical, Health & Wellness, Health & Fitness apps as defined by Apple and Google Play stores were searched. Apps were coded for BCTs according to the Michie et al. taxonomy. The taxonomy comprises 16 categories and 93 individual BCTs. BCT coding was conducted by two trained researchers (EE, JL who scored independently and then cross-checked for discrepancies. BCT numbers, user ratings and app pricing were compared. We explored the association between number of BCTs per app, user and NHS libraries’ ratings and price. We also investigated, which of the 16 BCT categories and the individual 93 BCTs and their combinations were most commonly used. Results: 1,680 Medical, Health & Wellness or Health & Fitness Apps were reviewed and seventy containing gamification techniques were identified. The mean number of BCTs used was 12.5 (range 1-24. There was no correlation between number of BCTs, customer ratings, NHS library app rating or

  20. 3rd MeTrApp Conference

    CERN Document Server

    Lovasz, Erwin-Christian; Hüsing, Mathias

    2015-01-01

    This volume deals with topics such as mechanism and machine design, biomechanics and medical engineering, gears, mechanical transmissions, mechatronics, computational and experimental methods, dynamics of mechanisms and machines, micromechanisms and microactuators, and history of mechanisms and transmissions. Following MeTrApp 2011 and 2013, held under the auspices of the IFToMM, these proceedings of the 3rd Conference on Mechanisms, Transmissions and Applications offer a platform for original research presentations for researchers, scientists, industry experts and students in the fields of mechanisms and transmissions with special emphasis on industrial applications in order to stimulate the exchange of new and innovative ideas.

  1. FysiApp iOS-alustalle

    OpenAIRE

    Seppänen, Maria

    2015-01-01

    Opinnäytetyö tehtiin PhysioBit Oy:lle ja aiheena oli luoda FysiApp-sovellus iOS-alustalle. Tarkoituksena oli saada aikaan sovellus, jonka avulla asiakas voisi suorittaa terveysalan ammattilaisen, fysioterapeutin tai personal trainerin suunnittelemia harjoitusohjelmia. Lisäksi sovelluksen avulla asiakas ja ammattilainen voivat viestitellä keskenään. Opinnäytetyön teko aloitettiin ensin tutustumalla iOS maailmaan ja Swift-ohjelmointikieleen. Ensimmäisenä sovel-lukseen tehtiin kirjautuminen ...

  2. Leakiness and Creepiness in App Space: User Perceptions of Privacy and Mobile App Use

    DEFF Research Database (Denmark)

    Shklovski, Irina; Mainwaring, Scott; Skúladóttir, Halla Hrund;

    2014-01-01

    confronted with app behaviors and their reactions assessed. Users felt their personal space had been violated in “creepy” ways. Using Altman’s notions of personal space and territoriality, and Nissenbaum’s theory of contextual integrity, we account for these emotional reactions and sug- gest that they point...

  3. Construction of Recombinant Plasmid Harboring APP717 Mutation and Preliminary Study of APP Proteolysis

    Institute of Scientific and Technical Information of China (English)

    LI Xiaoqing; XUE Zheng; ZHANG Suming

    2007-01-01

    In order to investigate the pathogenesis of Alzheimer disease (AD) and study the enzy-matic progress of amyloid precursor protein (APP), the fluorescent eukaryotic expression plasmid of C99 was constructed containing APP717 mutation. The fragment encoding the last 99-aa of APP(which was named C99 containing APP717 mutation), together with the fragment encoding yellow fluorescence protein (which was named YFP) were amplified by PCR. The two fragments (YFP andC99) were inserted into the vector pcDNA3.0. The recombinant plasmid pcDNA3.0-YFP-C99 was accomplished and its authenticity was confirmed by enzyme digestion and sequencing. Then SH-SY5Y cells were transiently transfected with the recombinant plasmid pcDNA3.0-YFP-C99. The expression of the fusion gene was detected by laser confocalmicroscopy. Amyloid-β (Aβ) was de- tected by both microscopy and immunochemistry. The authenticity of the construct was confirmed by the endonuclease digestion and DNA sequencing. The YFP fluorescence could be seen and proved the expression of fusion gene. Aβ labeled by YFP was detected by confocalmicroscopy and confirmed by immunocytochemistry. It was found that Aβ accumulated and deposited in the intracytoplasm, mem-brane and outside of the cell. Furthermore, Aβ accumulated mainly within the cell ahead of the depo-sition in the cell space and the cell shape was rough. It was suggested that Aβ could be generatedwithin the cells. Aβ accumulated in the cell at the early stage before the deposition outside of the cells.Intracellular Aβ accumulation induced the secondary damage to the cells and caused the cell shape rough. Taken together, the recombinant plasmid, pcDNA3.0-YFP-C99 could be a useful tool to fur-ther study the cleavage mechanism of APP and to explore the pathogenesis of AD.

  4. Ndel1-derived peptides modulate bidirectional transport of injected beads in the squid giant axon

    Directory of Open Access Journals (Sweden)

    Michal Segal

    2012-01-01

    Bidirectional transport is a key issue in cellular biology. It requires coordination between microtubule-associated molecular motors that work in opposing directions. The major retrograde and anterograde motors involved in bidirectional transport are cytoplasmic dynein and conventional kinesin, respectively. It is clear that failures in molecular motor activity bear severe consequences, especially in the nervous system. Neuronal migration may be impaired during brain development, and impaired molecular motor activity in the adult is one of the hallmarks of neurodegenerative diseases leading to neuronal cell death. The mechanisms that regulate or coordinate kinesin and dynein activity to generate bidirectional transport of the same cargo are of utmost importance. We examined how Ndel1, a cytoplasmic dynein binding protein, may regulate non-vesicular bidirectional transport. Soluble Ndel1 protein, Ndel1-derived peptides or control proteins were mixed with fluorescent beads, injected into the squid giant axon, and the bead movements were recorded using time-lapse microscopy. Automated tracking allowed for extraction and unbiased analysis of a large data set. Beads moved in both directions with a clear bias to the anterograde direction. Velocities were distributed over a broad range and were typically slower than those associated with fast vesicle transport. Ironically, the main effect of Ndel1 and its derived peptides was an enhancement of anterograde motion. We propose that they may function primarily by inhibition of dynein-dependent resistance, which suggests that both dynein and kinesin motors may remain engaged with microtubules during bidirectional transport.

  5. App-assisted external ventricular drain insertion.

    Science.gov (United States)

    Eftekhar, Behzad

    2016-09-01

    The freehand technique for insertion of an external ventricular drain (EVD) is based on fixed anatomical landmarks and does not take individual variations into consideration. A patient-tailored approach based on augmented-reality techniques using devices such as smartphones can address this shortcoming. The Sina neurosurgical assist (Sina) is an Android mobile device application (app) that was designed and developed to be used as a simple intraoperative neurosurgical planning aid. It overlaps the patient's images from previously performed CT or MRI studies on the image seen through the device camera. The device is held by an assistant who aligns the images and provides information about the relative position of the target and EVD to the surgeon who is performing EVD insertion. This app can be used to provide guidance and continuous monitoring during EVD placement. The author describes the technique of Sina-assisted EVD insertion into the frontal horn of the lateral ventricle and reports on its clinical application in 5 cases as well as the results of ex vivo studies of ease of use and precision. The technique has potential for further development and use with other augmented-reality devices. PMID:26654178

  6. 76 FR 49485 - Announcement of Requirements and Registration for “Lifeline Facebook App Challenge”

    Science.gov (United States)

    2011-08-10

    ... HUMAN SERVICES Announcement of Requirements and Registration for ``Lifeline Facebook App Challenge...: The ``Lifeline Facebook App Challenge'' is a challenge aimed at multidisciplinary teams of technology... Facebook as a platform for connecting individuals together through an application (app) that will...

  7. Citrix XenApp 7.5 desktop virtualization solutions

    CERN Document Server

    Paul, Andy

    2014-01-01

    If you are a Citrix® engineer, a virtualization consultant, or an IT project manager with prior experience of using Citrix XenApp® and related technologies for desktop virtualization and want to further explore the power of XenApp® for flawless desktop virtualization, then this book is for you.

  8. Microlearning mApp raises health competence: hybrid service design

    NARCIS (Netherlands)

    Simons, L.P.A.; Foerster, F.; Bruck, P.A.; Motiwalla, L.; Jonker, C.M.

    2015-01-01

    Work place health support interventions can help support our aging work force, with mApps offering cost-effectiveness opportunities. Previous research shows that health support apps should offer users enough newness and relevance each time they are used. Otherwise the ‘eHealth law of attrition’ appl

  9. Availability and quality of mobile health app privacy policies.

    Science.gov (United States)

    Sunyaev, Ali; Dehling, Tobias; Taylor, Patrick L; Mandl, Kenneth D

    2015-04-01

    Mobile health (mHealth) customers shopping for applications (apps) should be aware of app privacy practices so they can make informed decisions about purchase and use. We sought to assess the availability, scope, and transparency of mHealth app privacy policies on iOS and Android. Over 35,000 mHealth apps are available for iOS and Android. Of the 600 most commonly used apps, only 183 (30.5%) had privacy policies. Average policy length was 1755 (SD 1301) words with a reading grade level of 16 (SD 2.9). Two thirds (66.1%) of privacy policies did not specifically address the app itself. Our findings show that currently mHealth developers often fail to provide app privacy policies. The privacy policies that are available do not make information privacy practices transparent to users, require college-level literacy, and are often not focused on the app itself. Further research is warranted to address why privacy policies are often absent, opaque, or irrelevant, and to find a remedy. PMID:25147247

  10. Mobile Distance Learning with Smartphones and Apps in Higher Education

    Science.gov (United States)

    Vázquez-Cano, Esteban

    2014-01-01

    In this paper, the results of researcher' ongoing activities regarding the use of smartphones and a specific subject-app used at the Spanish National University of Distance Education (UNED) have been reported. The purpose of this trial is to assess the app's didactic use and potential to enhance student learning in university subjects in…

  11. Mobile Apps to Support and Assess Foreign Language Learning

    Science.gov (United States)

    Berns, Anke; Palomo-Duarte, Manuel; Dodero, Juan Manuel; Ruiz-Ladrón, Juan Miguel; Márquez, Andrea Calderón

    2015-01-01

    In the last two decades there have been many attempts to integrate all kinds of mobile devices and apps to support formal as well as informal learning processes. However, most of the available apps still support mainly individual learning, using mobile devices to deliver content rather than providing learners with the opportunity to interact with…

  12. An Analysis of WhatsApp Forensics in Android Smartphones

    OpenAIRE

    Shubham Sahu

    2014-01-01

    — WhatsApp is mobile application which allows exchange of messages, videos, audio’s and images via Smartphone. The increased use of IM on Android phones has turned to be goldmine for mobile and computer forensic investigators. This paper focuses on conducting forensic data analysis by extracting useful information from WhatsApp and from similar applications installed on Android platform.

  13. Building Android Apps with HTML, CSS, and JavaScript

    CERN Document Server

    Stark, Jonathan

    2010-01-01

    If you know HTML, CSS, and JavaScript, you already have the tools you need to develop Android applications. This hands-on book shows you how to use these open source web standards to design and build apps that can be adapted for any Android device -- without having to use Java. You'll learn how to create an Android-friendly web app on the platform of your choice, and then convert it to a native Android app with the free PhoneGap framework. Discover why device-agnostic mobile apps are the wave of the future, and start building apps that offer greater flexibility and a broader reach. Learn the

  14. Using Mobile App Development Tools to Build a GIS Application

    Science.gov (United States)

    Mital, A.; Catchen, M.; Mital, K.

    2014-12-01

    Our group designed and built working web, android, and IOS applications using different mapping libraries as bases on which to overlay fire data from NASA. The group originally planned to make app versions for Google Maps, Leaflet, and OpenLayers. However, because the Leaflet library did not properly load on Android, the group focused efforts on the other two mapping libraries. For Google Maps, the group first designed a UI for the web app and made a working version of the app. After updating the source of fire data to one which also provided historical fire data, the design had to be modified to include the extra data. After completing a working version of the web app, the group used webview in android, a built in resource which allowed porting the web app to android without rewriting the code for android. Upon completing this, the group found Apple IOS devices had a similar capability, and so decided to add an IOS app to the project using a function similar to webview. Alongside this effort, the group began implementing an OpenLayers fire map using a simpler UI. This web app was completed fairly quickly relative to Google Maps; however, it did not include functionality such as satellite imagery or searchable locations. The group finished the project with a working android version of the Google Maps based app supporting API levels 14-19 and an OpenLayers based app supporting API levels 8-19, as well as a Google Maps based IOS app supporting both old and new screen formats. This project was implemented by high school and college students under an SGT Inc. STEM internship program

  15. Apps and EFL: A Case Study on the Use of Smartphone Apps to Learn English by Four Japanese University Students

    Science.gov (United States)

    Mindog, Emily

    2016-01-01

    This study explores, describes and analyzes the utilization of smartphone apps by four Japanese university students to support learning English as a Foreign Language (EFL). Findings indicate that intermediate language learners use apps to access content and communicate on SNS and are not keen on studying discrete language parts. Participants…

  16. Building Android Apps with HTML, CSS, and JavaScript Making Native Apps with Standards-Based Web Tools

    CERN Document Server

    Stark, Jonathan

    2012-01-01

    It's true: if you know HTML, CSS, and JavaScript, you already have the tools you need to develop Android applications. Now updated for HTML5, the second edition of this hands-on guide shows you how to use open source web standards to design and build apps that can be adapted for any Android device. You'll learn how to create an Android-friendly web app on the platform of your choice, and then use Adobe's free PhoneGap framework to convert it to a native Android app. Discover why device-agnostic mobile apps are the wave of the future, and start building apps that offer greater flexibility and

  17. Instant RubyMotion app development

    CERN Document Server

    Laborde, Gant

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. This book is a practical, task-based, step-by-step tutorial that will get you started with using RubyMotion to quickly and efficiently write iOS apps.To make the most of this book, you should understand the basics of programming concepts and have a basic understanding of a language similar to Ruby. If you are an Objective-C programmer, you'll learn the advantages of RubyMotion which can access the benefits of Cocoapods, but takes everything a st

  18. The LibX LibApp Builder

    OpenAIRE

    Vijay, Sony

    2014-01-01

    LibX is a browser extension that provides direct access to library resources. LibX enables users to add additional features to a webpage, such as placing a tutorial video on a digital library homepage. LibX achieves this ability of enhancing web pages through library applications, called LibApps. A LibApp examines a webpage, extracts and processes information of the page, and modifies the web content. It is possible to build an unlimited number of LibApps and enhance web pages in numerous way...

  19. Grindr, hook-up apps, og medialiseringen as offentlig sexkultur

    OpenAIRE

    Jørgensen, Kristian Møller

    2016-01-01

    The mediatization of public sex cultures in the case of the hook-up app Grindr Along with the normalisation of geo-locative dating and hook-up practices in mainstream publics – through apps like Tinder, Bumble and Happn – imaginations of sexual privacy and indeed publicness seem to be changing. This paper focuses on the interplay between media and public sex cultures in the case of the Grindr app use in gay male intimacy cultures. Though gay men’s sex practices, vis-à-vis cruising, have histo...

  20. Instant EdgeSight for XenApp

    CERN Document Server

    Hasan, Vaqar

    2013-01-01

    Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. Instant EdgeSight for XenApp is a practical, hands-on guide that contains instruction-based examples from basic to advanced level topics. Instant EdgeSight for XenApp will serve as an excellent source of information for Citrix XenApp professionals and novices alike. It is assumed that readers have experience working with Citrix products and have some sort of familiarity with monitoring.

  1. The Med AppJam: a model for an interprofessional student-centered mHealth app competition.

    Science.gov (United States)

    Youm, Julie; Wiechmann, Warren

    2015-03-01

    The Med AppJam is a 2-week long competition where students from the University of California, Irvine School of Medicine are partnered with students from the University of California, Irvine School of Information and Computer Sciences in interprofessional teams to develop mobile health applications for use by clinicians and patients. The success of the Med AppJam comes from the unique opportunity for students to mutually contribute their content expertise to improve the clinical landscape while expanding their technology literacy and savvy. Since 2012, about 285 computer science students and over 90 medical students have collaborated to design and develop 53 iOS mHealth apps during the event. The Med AppJam model has been replicated in an Autism AppJam, a competition focused on the needs of a specific population, and with high school students in a mini Pre-Med AppJam using a paper prototyping approach. It is proposed that other medical schools consider implementation of a local Med AppJam as a viable model for engaging students in technology for healthcare.

  2. The Med AppJam: a model for an interprofessional student-centered mHealth app competition.

    Science.gov (United States)

    Youm, Julie; Wiechmann, Warren

    2015-03-01

    The Med AppJam is a 2-week long competition where students from the University of California, Irvine School of Medicine are partnered with students from the University of California, Irvine School of Information and Computer Sciences in interprofessional teams to develop mobile health applications for use by clinicians and patients. The success of the Med AppJam comes from the unique opportunity for students to mutually contribute their content expertise to improve the clinical landscape while expanding their technology literacy and savvy. Since 2012, about 285 computer science students and over 90 medical students have collaborated to design and develop 53 iOS mHealth apps during the event. The Med AppJam model has been replicated in an Autism AppJam, a competition focused on the needs of a specific population, and with high school students in a mini Pre-Med AppJam using a paper prototyping approach. It is proposed that other medical schools consider implementation of a local Med AppJam as a viable model for engaging students in technology for healthcare. PMID:25682357

  3. Discussion on the Construction of University Mobile Library APP%对高校移动图书馆 APP 建设的探讨

    Institute of Scientific and Technical Information of China (English)

    任海鹏

    2016-01-01

    This article,from the current situation of the mobile library APP construction,focuses on the lack of construction in the presence of APP mobile library,and then discusses how to really do a good job moving APP university library construction in China.%本文从我国移动图书馆 APP 建设现状着手,重点分析了移动图书馆 APP 建设中存在的不足,进而探讨了怎样才能真正做好我国高校移动图书馆 APP 建设。

  4. Evaluation of COTS Rad Detection Apps

    International Nuclear Information System (INIS)

    Mobile applications are currently under distribution to smart phones utilizing the built-in charge coupled-device (CCD) camera as a radiation detector. The CCD detector has a very low but measurable gamma interaction cross section so the mechanism is feasible, especially for higher dose rate environments. Given that in a large release of radioactive material these 'crowd sourced' measurements will be put forth for consideration, a testing and evaluation of the accuracy and uncertainty of the Apps is a critical endeavor. Not only is the accuracy of the reported measurement of concern to the immediate user's safety, a quantitative uncertainty is required for a government response such as the Federal Radiological Monitoring and Assessment Center (FRMAC) to accept the values for consideration in the determination of regions exceeding protective action guidelines. Already, prompted by the Fukushima nuclear material releases, several repositories of this crowd-sourced data have been created (http://japan.failedrobot.com, http://www.stubbytour.com/nuc/index_en.asp, and http://www.rdtn.org) although the question remains as to the reliability of measurements incorporated into these repositories. In cases of conflict between the real-time published crowd-sourced data and governmental protective actions prepared literature should be on-hand documenting why the difference, if any, exists. Four applications for iOS devices were obtained along with hardware to benchmark their performance. Gamma/X-Ray Detector by Stephan Hotto, Geiger Camera by Senscare, and RadioactivityCounter App by Hotray LTD are all the applications available for distribution within the US that utilize the CCD camera sensor for detection of radiation levels. The CellRad app under development by Idaho National Laboratory for the Android platform was evaluated. In addition, iRad Geiger with the associated hardware accessory was also benchmarked. Radiation fields were generated in a Cs-137 JL

  5. Evaluation of COTS Rad Detection Apps

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Eric [National Security Technologies, LLC. (NSTec), Mercury, NV (United States)

    2014-02-01

    Mobile applications are currently under distribution to smart phones utilizing the built-in charge coupled-device (CCD) camera as a radiation detector. The CCD detector has a very low but measurable gamma interaction cross section so the mechanism is feasible, especially for higher dose rate environments. Given that in a large release of radioactive material these ‘crowd sourced’ measurements will be put forth for consideration, a testing and evaluation of the accuracy and uncertainty of the Apps is a critical endeavor. Not only is the accuracy of the reported measurement of concern to the immediate user’s safety, a quantitative uncertainty is required for a government response such as the Federal Radiological Monitoring and Assessment Center (FRMAC) to accept the values for consideration in the determination of regions exceeding protective action guidelines. Already, prompted by the Fukushima nuclear material releases, several repositories of this crowd-sourced data have been created (http://japan.failedrobot.com, http://www.stubbytour.com/nuc/index_en.asp, and http://www.rdtn.org) although the question remains as to the reliability of measurements incorporated into these repositories. In cases of conflict between the real-time published crowd-sourced data and governmental protective actions prepared literature should be on-hand documenting why the difference, if any, exists. Four applications for iOS devices were obtained along with hardware to benchmark their performance. Gamma/X-Ray Detector by Stephan Hotto, Geiger Camera by Senscare, and RadioactivityCounter App by Hotray LTD are all the applications available for distribution within the US that utilize the CCD camera sensor for detection of radiation levels. The CellRad app under development by Idaho National Laboratory for the Android platform was evaluated. In addition, iRad Geiger with the associated hardware accessory was also benchmarked. Radiation fields were generated in a Cs-137 JL Shepherd

  6. Persian mHealth Apps: A Cross Sectional Study Based on Use Case Classification.

    Science.gov (United States)

    Saeedi, Marjan Ghazi; Kalhori, Sharareh Rostam Niakan; Nouria, Rasool; Yasini, Mobin

    2016-01-01

    Mobile health apps play an important role in healthcare processes and health promotion. In recent years many Persian mhealth apps were developed and are available in various national app markets. Cafebazaar is the largest Persian app store that contains more than 3500 android apps in medical and health & fitness categories. In this study some characteristics of 200 top Persian medical apps of Cafebazaar were investigated and then categorized by their use cases. Results showed that only 6% of apps declare the involvement of at least one health professional in the conception or development of the apps. In 35% of studied apps, no contact information was provided for the users and 10.5% applied reliable sources for their content. 13 distinct use cases were found in all 200 apps of which two were new to an already published use-case model. This study shows that Persian mHealth apps, like other existing apps in the world, have a long way to improve and reach some basic standards. Lack of regulatory agencies and absence of a dynamic evaluation system for mHealth apps might be the main reason of these defects. This study also shows that 20 use cases existing in international health related apps are not yet used in Persian apps and therefore there is a reach potential of creating new apps in mHealth field.

  7. The Quality and Accuracy of Mobile Apps to Prevent Driving After Drinking Alcohol

    Science.gov (United States)

    Stoyanov, Stoyan R; Gandabhai, Shailen; Baldwin, Alexander

    2016-01-01

    Background Driving after the consumption of alcohol represents a significant problem globally. Individual prevention countermeasures such as personalized mobile apps aimed at preventing such behavior are widespread, but there is little research on their accuracy and evidence base. There has been no known assessment investigating the quality of such apps. Objective This study aimed to determine the quality and accuracy of apps for drink driving prevention by conducting a review and evaluation of relevant mobile apps. Methods A systematic app search was conducted following PRISMA guidelines. App quality was assessed using the Mobile App Rating Scale (MARS). Apps providing blood alcohol calculators (hereafter “calculators”) were reviewed against current alcohol advice for accuracy. Results A total of 58 apps (30 iOS and 28 Android) met inclusion criteria and were included in the final analysis. Drink driving prevention apps had significantly lower engagement and overall quality scores than alcohol management apps. Most calculators provided conservative blood alcohol content (BAC) time until sober calculations. None of the apps had been evaluated to determine their efficacy in changing either drinking or driving behaviors. Conclusions This novel study demonstrates that most drink driving prevention apps are not engaging and lack accuracy. They could be improved by increasing engagement features, such as gamification. Further research should examine the context and motivations for using apps to prevent driving after drinking in at-risk populations. Development of drink driving prevention apps should incorporate evidence-based information and guidance, lacking in current apps. PMID:27502956

  8. Using apps for learning across the curriculum a literacy-based framework and guide

    CERN Document Server

    Beach, Richard

    2014-01-01

    How can apps be used to foster learning with literacy across the curriculum? This book offers both a theoretical framework for considering app affordances and practical ways to use apps to build students' disciplinary literacies and to foster a wide range of literacy practices.Using Apps for Learning Across the Curriculumpresents a wide range of different apps and also assesses their value features methods for and apps related to planning instruction and assessing student learning identifies favorite apps whose affordances are most likely to foster certain disciplinary literacies includes reso

  9. Bootstrapping Security Policies for Wearable Apps Using Attributed Structural Graphs.

    Science.gov (United States)

    González-Tablas, Ana I; Tapiador, Juan E

    2016-05-11

    We address the problem of bootstrapping security and privacy policies for newly-deployed apps in wireless body area networks (WBAN) composed of smartphones, sensors and other wearable devices. We introduce a framework to model such a WBAN as an undirected graph whose vertices correspond to devices, apps and app resources, while edges model structural relationships among them. This graph is then augmented with attributes capturing the features of each entity together with user-defined tags. We then adapt available graph-based similarity metrics to find the closest app to a new one to be deployed, with the aim of reusing, and possibly adapting, its security policy. We illustrate our approach through a detailed smartphone ecosystem case study. Our results suggest that the scheme can provide users with a reasonably good policy that is consistent with the user's security preferences implicitly captured by policies already in place.

  10. Appreneur secrets to success in the app store

    CERN Document Server

    Pierce, Taylor

    2013-01-01

    You are interested in making an app. You have read all of the stories of successful developers and appreneurs. You are determined to get a piece of the pie. The world of apps is the fastest growing market in the world today, and it is here to stay. The best part is you can get in on it! Now what if I told you that without the knowledge contained in this book the odds of you making a profit are slim to none? What if I also told you that you probably wouldn't break even? There is more to apps than most people think. The average person assumes that if they make an app, they will instantly become

  11. Bootstrapping Security Policies for Wearable Apps Using Attributed Structural Graphs

    Directory of Open Access Journals (Sweden)

    Ana I. González-Tablas

    2016-05-01

    Full Text Available We address the problem of bootstrapping security and privacy policies for newly-deployed apps in wireless body area networks (WBAN composed of smartphones, sensors and other wearable devices. We introduce a framework to model such a WBAN as an undirected graph whose vertices correspond to devices, apps and app resources, while edges model structural relationships among them. This graph is then augmented with attributes capturing the features of each entity together with user-defined tags. We then adapt available graph-based similarity metrics to find the closest app to a new one to be deployed, with the aim of reusing, and possibly adapting, its security policy. We illustrate our approach through a detailed smartphone ecosystem case study. Our results suggest that the scheme can provide users with a reasonably good policy that is consistent with the user’s security preferences implicitly captured by policies already in place.

  12. Heart Attack Help? There's an App for That

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_159504.html Heart Attack Help? There's an App for That Emergency medicine ... American Heart Association. When someone is suffering a heart attack, stroke or cardiac arrest, quick action can be ...

  13. 那些神一样的App

    Institute of Scientific and Technical Information of China (English)

    金姬; 刘绮黎

    2013-01-01

    2013年5月16日,苹果App Store的App下载量突破500亿次,App数量也高达85万。为了庆祝这一历史时刻,苹果公布了App Store成立5年以来25款最畅销应用榜单。有趣的是,榜单上的许多App是早期推出的,这可能与App Store的盈利模式有关——在App Store上,一款新App下载是通常是免费的,但升级该

  14. CELSTEC Learning Labs: Mobile App Development for Education and Training

    NARCIS (Netherlands)

    Specht, Marcus

    2011-01-01

    Specht, M. (2011). CELSTEC Learning Labs: Mobile App Development for Education and Training. Presentation given in Workshop at CELSTEC Learning Lab for Bluetea. February, 21, 2011, Heerlen, The Netherlands.

  15. iPhone Location Aware Apps by Example - Beginners Guide

    CERN Document Server

    Chawdhary, Zeeshan

    2012-01-01

    Using a By example approach you will master the essentials of location awareness and augmented reality by building five complete apps using easy to follow step by step instructions geared towards newcomers. Novice to professional level iOS programmers who want to master location awareness and augmented reality. Build five practical location-based iOS Apps from scratch, a first for any book, converting learning into actual implementation.

  16. Prototype of an Augmented Reality User Manual App

    OpenAIRE

    Palm, Fredrik; Källström, Filip

    2014-01-01

    This thesis describes how augmented reality can be used when developing an instructional application. After studying augmented reality apps and papers, a prototype for mobile devices was developed to discover the possibilities that augmented reality offers and show how issues inherent to the technology can be solved. The app was developed with usability in mind, with consideration for how well suited each feature was for augmented reality. Our results show that it is possible to use augmented...

  17. AppServ的安全测试

    Institute of Scientific and Technical Information of China (English)

    qapache

    2006-01-01

    AppServ是PHP网页架站工具组合包.这是一名泰国的作者将一些网络上免费的架站资源重新包装起来的安装程序.非常适合初学者快速完成架站。AppServ所包含的软件有Apache、ApacheMonitor、PHP、MYSQL、PHP—Nuke、PHPMYAdmin。

  18. Rapid software development : ANALYSIS OF AGILE METHODS FOR APP STARTUPS

    OpenAIRE

    Wahlqvist, Daniel

    2014-01-01

    This thesis is focused on software development using so called Agile methods. The scope of research is startup companies creating consumer apps. The thesis work was performed at a Swedish app startup; Storypic/Accelit AB. An overview of current research on Agile methods is given. A qualitative case study was undertaken in four parts; 1. Observing the team 2. Testing business hypotheses 3. Interviews with the team and 4. User feedback. Analyzing the findings some conclusions are drawn:  An ag...

  19. An Analysis of WhatsApp Forensics in Android Smartphones

    Directory of Open Access Journals (Sweden)

    Shubham Sahu

    2014-05-01

    Full Text Available — WhatsApp is mobile application which allows exchange of messages, videos, audio’s and images via Smartphone. The increased use of IM on Android phones has turned to be goldmine for mobile and computer forensic investigators. This paper focuses on conducting forensic data analysis by extracting useful information from WhatsApp and from similar applications installed on Android platform.

  20. Melanoma detection using a mobile phone app

    Science.gov (United States)

    Diniz, Luciano E.; Ennser, K.

    2016-03-01

    Mobile phones have had their processing power greatly increased since their invention a few decades ago. As a direct result of Moore's Law, this improvement has made available several applications that were impossible before. The aim of this project is to develop a mobile phone app, integrated with its camera coupled to an amplifying lens, to help distinguish melanoma. The proposed device has the capability of processing skin mole images and suggesting, using a score system, if it is a case of melanoma or not. This score system is based on the ABCDE signs of melanoma, and takes into account the area, the perimeter and the colors present in the nevus. It was calibrated and tested using images from the PH2 Dermoscopic Image Database from Pedro Hispano Hospital. The results show that the system created can be useful, with an accuracy of up to 100% for malign cases and 80% for benign cases (including common and atypical moles), when used in the test group.

  1. The Analysis Of Smartphone Apps In Geomatics Education

    Science.gov (United States)

    Teo, T.-A.; Wu, H.-M.; Shih, T.-Y.; Tsai, F.

    2014-04-01

    Geomatics is a discipline of collecting, processing and analysing geospatial data. Data collection is a core process of geomatics which usually adopt precise equipment to measure geospatial data. With the development of technology, a smartphone in this present era is not simply for communication; several low cost measurement devices such as Global Positioning System (GPS), gyro and camera are assembled in a smartphone. Although the devices assembled in a smartphone could not meet the needs of accuracy requirement for many geomatics applications, millions of mobile applications (Apps) can be downloaded and installed from Google Play and Apple Store freely, and a variety of sensors can be chosen for user. Considering that the popularity and convenience of a smartphone, and assuming that the accuracy of those collected data is acceptable for learning purposes, it is expected that a smartphone can be employed in geomatics for hand-on education. For example, Vespucci OSM Editor is an App to edit the OpenStreetMap on Android. The user may have the hand-on experience on GPS positioning, web services and mapping via Vespucci OSM Editor. The aim of this paper is to collect and analyze different Apps for geomatics education. The Apps are classified into four categories, namely, surveying, remote sensing, GPS and Geographic Information System (GIS). In this paper, more than 20 free Apps are collected and analysed for different hand-on studies in geomatics education. Finally, all the related Apps are listed on a website for updating.

  2. SHARING IS CARING: A DATA EXCHANGE FRAMEWORK FOR CO-LOCATED MOBILE APPS

    OpenAIRE

    Joseph Milazzo; Priyanka Bagade; Ayan Banerjee; Gupta, Sandeep K. S.

    2014-01-01

    Data sharing between mobile apps that are co-located in a smartphone may lead to synergistic benefits to the user especially in the health-care domain. Mobile apps that monitor and control user behavior can interact to engage the user into a healthy schedule over a long term. In the current app development paradigm, apps are being developed individually and agnostic of each other. To enable interaction between apps in secure manner, collaboration between developers is needed, w...

  3. mHealth in Urology: A Review of Experts' Involvement in App Development.

    Directory of Open Access Journals (Sweden)

    Nuno Pereira-Azevedo

    Full Text Available Smartphones are increasingly playing a role in healthcare and previous studies assessing medical applications (apps have raised concerns about lack of expert involvement and low content accuracy. However, there are no such studies in Urology. We reviewed Urology apps with the aim of assessing the level of participation of healthcare professionals (HCP and scientific Urology associations in their development.A systematic search was performed on PubMed, Apple's App Store and Google's Play Store, for Urology apps, available in English. Apps were reviewed by three graders to determine the app's platform, target customer, developer, app type, app category, price and the participation of a HCP or a scientific Urology association in the development.The search yielded 372 apps, of which 150 were specific for Urology. A fifth of all apps had no HCP involvement (20.7% and only a third had been developed with a scientific Urology association (34.7%. The lowest percentage of HCP (13.4% and urological association (1.9% involvement was in apps designed for the general population. Furthermore, there was no contribution from an Urology society in "Electronic Medical Record" nor in "Patient Information" apps. A limitation of the study is that only Android and iOS apps were reviewed.Despite the increasing Mobile Health (mHealth market, this is the first study that demonstrates the lack of expert participation in the design of Urology apps, particularly in apps designed for the general public. Until clear regulation is enforced, the urological community should help regulate app development. Maintaining a register of certified apps or issuing an official scientific seal of approval could improve overall app quality. We propose that urologists become stakeholders in mHealth, shaping future app design and promoting peer-review app validation.

  4. Developing A mobile App for the Rehabilitation of Ankle Sprains

    Directory of Open Access Journals (Sweden)

    Suzanne McDonough

    2015-10-01

    Full Text Available Background: Musculoskeletal injuries are common and costly. Ankle sprains are one of the most common such injuries, carrying significant risk of persistent disabling symptoms. Rehabilitation has been shown to be more effective than standard conservative approaches for musculoskeletal injuries. The use of a mobile app to present rehabilitation guidance may offer a more accessible, engaging and effective solution to ankle sprain rehabilitation. Several existing apps target the prevention and rehabilitation of ankle sprains, however evaluation details are limited. Aim: To develop a mobile phone app that provides interactive, personalised and tailored rehabilitation for people following ankle sprains. Method(s: In order to build requirements and produce content for the app (entitled ReApp 2, relevant literature was reviewed and behaviour change strategies identified from the Behaviour Change Taxonomy (BCT developed by Michie et al (2013. A flexible and team orientated methodology called Agile was used to refine the technical specification and implemented software using feedback from technical experts (n=5 and clinicians (n=6. Technical experts consisted of participants with at least five years of experience in ICT or a related discipline. These technical experts completed the System Usability Scale (SUS to rate the usability of the software. The SUS is a widely used usability survey, which provides a single overall score for each participant. These scores can be used to provide comparison between user groups and other software. The clinicians consisted of five physiotherapists and one sport and exercise consultant, all of whom had at least five years of experience in providing rehabilitation treatment for ankle injuries. These clinicians also completed a questionnaire and gave qualitative feedback on the clinical appropriateness of the app. Results: The identified BCTs were prioritised according to clinical importance, technical complexity and time

  5. IDEAS and App Development Internship in Hardware and Software Design

    Science.gov (United States)

    Alrayes, Rabab D.

    2016-01-01

    In this report, I will discuss the tasks and projects I have completed while working as an electrical engineering intern during the spring semester of 2016 at NASA Kennedy Space Center. In the field of software development, I completed tasks for the G-O Caching Mobile App and the Asbestos Management Information System (AMIS) Web App. The G-O Caching Mobile App was written in HTML, CSS, and JavaScript on the Cordova framework, while the AMIS Web App is written in HTML, CSS, JavaScript, and C# on the AngularJS framework. My goals and objectives on these two projects were to produce an app with an eye-catching and intuitive User Interface (UI), which will attract more employees to participate; to produce a fully-tested, fully functional app which supports workforce engagement and exploration; to produce a fully-tested, fully functional web app that assists technicians working in asbestos management. I also worked in hardware development on the Integrated Display and Environmental Awareness System (IDEAS) wearable technology project. My tasks on this project were focused in PCB design and camera integration. My goals and objectives for this project were to successfully integrate fully functioning custom hardware extenders on the wearable technology headset to minimize the size of hardware on the smart glasses headset for maximum user comfort; to successfully integrate fully functioning camera onto the headset. By the end of this semester, I was able to successfully develop four extender boards to minimize hardware on the headset, and assisted in integrating a fully-functioning camera into the system.

  6. How Dangerous Are Your Smartphones? App Usage Recommendation with Privacy Preserving

    Directory of Open Access Journals (Sweden)

    Konglin Zhu

    2016-01-01

    Full Text Available With the rapid proliferation of mobile devices, explosive mobile applications (apps are developed in the past few years. However, the functions of mobile apps are varied and the designs of them are not well understood by end users, especially the activities and functions related to user privacy. Therefore, understanding how much danger of mobile apps with respect to privacy violation to mobile users is becomes a critical issue when people use mobile devices. In this paper, we evaluate the mobile app privacy violation of mobile users by computing the danger coefficient. In order to help people reduce the privacy leakage, we combine both the user preference to mobile apps and the privacy risk of apps and propose a mobile app usage recommendation method named AppURank to recommend the secure apps with the same function as the “dangerous” one for people use. The evaluation results show that our recommendation can reduce the privacy leakage by 50%.

  7. Pro iOS Geo building apps with location based services

    CERN Document Server

    Andreucci, Giacomo

    2013-01-01

    Deepen your app development skills with Pro iOS Geo. This book shows you how to use geolocation-based tools to enhance the iOS apps you develop. Author Giacomo Andreucci describes different ways to integrate geo services, depending on the kind of app you're looking to develop: a web app, a hybrid app, or a native app. You'll discover how to use the Google Maps API features to integrate powerful geo capabilities in your apps with a little effort. You'll learn how to: Design geographic features for your apps while respecting usability criteria Design touristic geo apps Use HTML5 and the Google M

  8. APP Homodimers Transduce an Amyloid-β-Mediated Increase in Release Probability at Excitatory Synapses

    Directory of Open Access Journals (Sweden)

    Hilla Fogel

    2014-06-01

    Full Text Available Accumulation of amyloid-β peptides (Aβ, the proteolytic products of the amyloid precursor protein (APP, induces a variety of synaptic dysfunctions ranging from hyperactivity to depression that are thought to cause cognitive decline in Alzheimer’s disease. While depression of synaptic transmission has been extensively studied, the mechanisms underlying synaptic hyperactivity remain unknown. Here, we show that Aβ40 monomers and dimers augment release probability through local fine-tuning of APP-APP interactions at excitatory hippocampal boutons. Aβ40 binds to the APP, increases the APP homodimer fraction at the plasma membrane, and promotes APP-APP interactions. The APP activation induces structural rearrangements in the APP/Gi/o-protein complex, boosting presynaptic calcium flux and vesicle release. The APP growth-factor-like domain (GFLD mediates APP-APP conformational changes and presynaptic enhancement. Thus, the APP homodimer constitutes a presynaptic receptor that transduces signal from Aβ40 to glutamate release. Excessive APP activation may initiate a positive feedback loop, contributing to hippocampal hyperactivity in Alzheimer’s disease.

  9. The challenges of co-developing a behaviour change app that aimed to make physical activity a habit

    Directory of Open Access Journals (Sweden)

    Alice S Forster

    2016-01-01

    Developers of behaviour change apps must balance the demands of users that will make using the app a habit, while retaining the ingredients necessary for the app to achieve its purpose. Mixed methods provide a rich data set with which to base app development and greater confidence that the app will meet the needs of users in terms of social networking and privacy.

  10. The AppComposer Web application for school teachers: A platform for translating and adapting educational web applications

    NARCIS (Netherlands)

    Rodriguez-Gil, Luis; Orduna, Pablo; Bollen, Lars; Govaerts, Sten; Holzer, Adrian; Gillet, Dennis; Lopez-de-Ipina, Diego; Garcia-Zubia, Javier

    2015-01-01

    Developing educational apps that cover a wide range of learning contexts and languages is a challenging task. In this paper, we introduce the AppComposer Web app to address this issue. The AppComposer aims at empowering teachers to easily translate and adapt existing apps that fit their educational

  11. Popular Nutrition-Related Mobile Apps: A Feature Assessment

    Science.gov (United States)

    Fallaize, Rosalind; Lovegrove, Julie A; Hwang, Faustina

    2016-01-01

    Background A key challenge in human nutrition is the assessment of usual food intake. This is of particular interest given recent proposals of eHealth personalized interventions. The adoption of mobile phones has created an opportunity for assessing and improving nutrient intake as they can be used for digitalizing dietary assessments and providing feedback. In the last few years, hundreds of nutrition-related mobile apps have been launched and installed by millions of users. Objective This study aims to analyze the main features of the most popular nutrition apps and to compare their strategies and technologies for dietary assessment and user feedback. Methods Apps were selected from the two largest online stores of the most popular mobile operating systems—the Google Play Store for Android and the iTunes App Store for iOS—based on popularity as measured by the number of installs and reviews. The keywords used in the search were as follows: calorie(s), diet, diet tracker, dietician, dietitian, eating, fit, fitness, food, food diary, food tracker, health, lose weight, nutrition, nutritionist, weight, weight loss, weight management, weight watcher, and ww calculator. The inclusion criteria were as follows: English language, minimum number of installs (1 million for Google Play Store) or reviews (7500 for iTunes App Store), relation to nutrition (ie, diet monitoring or recommendation), and independence from any device (eg, wearable) or subscription. Results A total of 13 apps were classified as popular for inclusion in the analysis. Nine apps offered prospective recording of food intake using a food diary feature. Food selection was available via text search or barcode scanner technologies. Portion size selection was only textual (ie, without images or icons). All nine of these apps were also capable of collecting physical activity (PA) information using self-report, the global positioning system (GPS), or wearable integrations. Their outputs focused

  12. Dynamics of mitochondrial transport in axons

    Directory of Open Access Journals (Sweden)

    Robert Francis Niescier

    2016-05-01

    Full Text Available The polarized structure and long neurites of neurons pose a unique challenge for proper mitochondrial distribution. It is widely accepted that mitochondria move from the cell body to axon ends and vice versa; however, we have found that mitochondria originating from the axon ends moving in the retrograde direction never reach to the cell body, and only a limited number of mitochondria moving in the anterograde direction from the cell body arrive at the axon ends of mouse hippocampal neurons. Furthermore, we have derived a mathematical formula using the Fokker-Planck equation to characterize features of mitochondrial transport, and the equation could determine altered mitochondrial transport in axons overexpressing parkin. Our analysis will provide new insights into the dynamics of mitochondrial transport in axons of normal and unhealthy neurons.

  13. Dynamics of Mitochondrial Transport in Axons.

    Science.gov (United States)

    Niescier, Robert F; Kwak, Sang Kyu; Joo, Se Hun; Chang, Karen T; Min, Kyung-Tai

    2016-01-01

    The polarized structure and long neurites of neurons pose a unique challenge for proper mitochondrial distribution. It is widely accepted that mitochondria move from the cell body to axon ends and vice versa; however, we have found that mitochondria originating from the axon ends moving in the retrograde direction never reach to the cell body, and only a limited number of mitochondria moving in the anterograde direction from the cell body arrive at the axon ends of mouse hippocampal neurons. Furthermore, we have derived a mathematical formula using the Fokker-Planck equation to characterize features of mitochondrial transport, and the equation could determine altered mitochondrial transport in axons overexpressing parkin. Our analysis will provide new insights into the dynamics of mitochondrial transport in axons of normal and unhealthy neurons. PMID:27242435

  14. Innovative genomic collaboration using the GENESIS (GEM.app) platform.

    Science.gov (United States)

    Gonzalez, Michael; Falk, Marni J; Gai, Xiaowu; Postrel, Richard; Schüle, Rebecca; Zuchner, Stephan

    2015-10-01

    Next-generation sequencing has led to an unparalleled pace of Mendelian disease gene discovery in recent years. To address the challenges of analysis and sharing of large datasets, we had previously introduced the collaborative web-based GEM.app software [Gonzalez et al., ]. Here, we are presenting the results of using GEM.app over nearly 3 years and introducing the next generation of this platform. First, GEM.app has been renamed to GENESIS since it is now part of "The Genesis Project" (501c3), a not-for-profit foundation that is committed to providing the best technology to enable research scientists and to connecting patients and clinicians to genomic information. Second, GENESIS (GEM.app) has grown to nearly 600 registered users from 44 countries, who have collectively achieved 62 gene identifications or published studies that have expanded phenotype/genotype correlations. Our concept of user-driven data sharing and matchmaking is now the main cause for gene discoveries within GENESIS. In many of these findings, researchers from across the globe have been connected, which gave rise to the genetic evidence needed to successfully pinpoint-specific gene mutations that explained patients' disease. Here, we present an overview of the various novel insights that have been made possible through the data-sharing capabilities of GENESIS/GEM.app. PMID:26173844

  15. LUMOR: an app for standardized control and monitoring of a porcine lung and its nutrient cycle.

    Science.gov (United States)

    Lenz, Gregor; Frohner, Matthias; Sauermann, Stefan; Forjan, Mathias

    2014-01-01

    The outcome of the EU-funded project ElBik has been the lung simulator 'iLung', which imitates an actively breathing human lung with a porcine lung. In order to keep the explanted lung in a nearly physiological state during transportation from the slaughterhouse to the ventilation laboratory the tissue needs to be nourished and temperature controlled. The Project AlveoPic designs a mobile transport vehicle implementing an ISO/IEEE 11073-20601 compliant communication interface for the exchange of the physical parameters, alert messages and setpoint-values. An appropriate 11073 domain information model is designed and limitations of the defined services and attributes are identified. For monitoring purposes the Android App LUMOR is implemented providing a user with an easy-to-handle GUI. It was found, that alert capabilities and remote set features are not well supported in ISO/IEEE 11073-20601 at the moment and possible workarounds are discussed. PMID:24825688

  16. Mobile App to Assess Universal Access Compliance.

    Science.gov (United States)

    Fransolet, Colette

    2016-01-01

    terms of compliance with National Building Regulations, within a tight budget as well as within minimal timeframes, an innovative mobile application was developed by Universal Design Africa. This App heralds the dawn of a new method to measure universal access compliance. The operation and format of this technology and its application could be adapted to meet all forms of compliance and information gathering, including international regulations and best practice. PMID:27534362

  17. Android arcade game app a real world project : case study approach

    CERN Document Server

    DiMarzio, Jerome

    2012-01-01

    Apress, the leading Android books publisher, continues to provide you with very hands-on, practical books for teaching and showing app developers how to build and design apps, including game apps, that can be built and deployed in the various Android app stores out there. Android Arcade Game App:  A Real World Project - Case Study Approach is no different in that it walks you through creating an arcade style Prison Break game app-top to bottom-for an Android smartphone or tablet.  This book teaches you the unique characteristics and challenges of creating an Arcade style game And it provides y

  18. Building cross-platform apps using Titanium, Alloy, and Appcelerator cloud services

    CERN Document Server

    Saunders, Aaron

    2014-01-01

    Skip Objective-C and Java to get your app to market faster, using the skills you already have Building Cross-Platform Apps using Titanium, Alloy, and Appcelerator Cloud Services shows you how to build cross-platform iOS and Android apps without learning Objective-C or Java. With detailed guidance given toward using the Titanium Mobile Platform and Appcelerator Cloud Services, you will quickly develop the skills to build real, native apps- not web apps-using existing HTML, CSS, and JavaScript know-how. This guide takes you step-by-step through the creation of a photo-sharing app that leverages

  19. Learning iPhone Programming From Xcode to App Store

    CERN Document Server

    Allan, Alasdair

    2010-01-01

    Get the hands-on experience you need to program for the iPhone and iPod Touch. With this easy-to-follow guide, you'll build several sample applications by learning how to use Xcode tools, the Objective-C programming language, and the core frameworks. Before you know it, you'll not only have the skills to develop your own apps, you'll know how to sail through the process of submitting apps to the iTunes App Store. Whether you're a developer new to Mac programming or an experienced Mac developer ready to tackle the iPhone and iPod Touch, Learning iPhone Programming will give you a head start o

  20. Exploring the materiality of literary apps for children

    DEFF Research Database (Denmark)

    Henkel, Ayoe Qvist

    2016-01-01

    to explore the manifestation of children’s literature – its materiality in particular. Exploring and analyzing the app Sofus and the Moonmachine by Burup, Jensen, Skovmand, and Vedel (The Outer Zone 2016), which integrates various art forms, sensory appeals and prompt different reading paths and types...... of interaction, this article suggests how a materiality approach can shed light on the formation of meaning in literary apps for children. The analysis is founded on three aspects of materiality of literary apps: its manifestation as text, its embedment in a medium, and its manner of being and interacting...... with the world. N. Katherine Hayles has developed a specific depth in emphasizing the materiality of literature, and her theoretical framework will be combined with cultural theory on materiality and theory on children’s literature in order to examine how the concept of materiality may be used in approaching...

  1. KAJIAN iOS APPS DALAM PENINGKATAN PRODUKTIFITAS PERANCANGAN ARSITEKTUR

    Directory of Open Access Journals (Sweden)

    Riva Tomasowa

    2014-12-01

    Full Text Available The use of mobile device with sophisticated hardware and smart apps is a robust tool in terms of improving productivity nowadays, as well as to the dynamic architecture design process. The communication is not merely limited to formal audio and visual, but also bridges the data synchronisation, time and distance. However, this novel technology is not fully adopted to support the design process. This paper describes the built iOS apps which designed to aid the architects and then compares their potential on each design phases. Discussion of the analysis based on the design flow of the feasibility study (feasibility study to facility management - FM, which discusses the ability of CAAD in the design stage. In brief, the research shows the absence of rigid framework for interoperability that could accommodate two ways information exchange between apps and desktop applications.

  2. Topic Space: Rapid Prototyping a Mobile Augmented Reality Recommendation App

    Directory of Open Access Journals (Sweden)

    Jim Hahn

    2015-10-01

    Full Text Available With funding from an Institute of Museum and Library Services (IMLS Sparks! Ignition Grant, researchers from the University of Illinois Library designed and tested a mobile recommender app with augmented reality features. By embedding open source optical character recognition software into a “Topic Space” module, the augmented reality app can recognize call numbers on a book in the library and suggest relevant items that are not shelved nearby. Topic Space can also show users items that are normally shelved in the starting location but that are currently checked out. Using formative UX methods, grant staff shaped app interface and functionality through early user testing. This paper reports results of UX testing; a redesigned mobile interface, and provides considerations on the future development of personalized recommendation functionality.

  3. SHARING IS CARING: A DATA EXCHANGE FRAMEWORK FOR CO-LOCATED MOBILE APPS

    Directory of Open Access Journals (Sweden)

    Joseph Milazzo

    2014-08-01

    Full Text Available Data sharing between mobile apps that are co-located in a smartphone may lead to synergistic benefits to the user especially in the health-care domain. Mobile apps that monitor and control user behavior can interact to engage the user into a healthy schedule over a long term. In the current app development paradigm, apps are being developed individually and agnostic of each other. To enable interaction between apps in secure manner, collaboration between developers is needed, which can be problematic on many levels. Current approaches to app integration require large code modifications to reap the benefits of shared data such as requiring developers to provide APIs or ensuring security through elaborate measures. In order to promote app interaction, this paper proposes a non-invasive secure interface for data sharing between mobile apps. A separate app, called the Health-Dev data manager, acts as a registry to allow apps to register database tables to be shared. Two health monitoring apps are developed to evaluate the sharing framework and different methods of data integration between apps. The health monitoring apps have shown non-invasive solutions can provide data sharing functionality without large code modifications and collaboration between developers.

  4. Learn to read and write: app for the literacy learning

    Directory of Open Access Journals (Sweden)

    Raquel GÓMEZ-DÍAZ

    2015-12-01

    Full Text Available Increasing tablets and educational apps aimed at kids made necessary, besides analyzing the advantages and disadvantages of their use in the classroom, have a better understanding of the applications themselves, their characteristics, business models, etc. The article focuses on the apps intended for literacy learning, and offers, along with a typology, and a selection of some of them. Finally, it includes a list of sources that will help teachers in the task of selecting the most suitable for the needs of pupils’ applications.

  5. Developing a smartphone app to support the nursing community.

    Science.gov (United States)

    Colton, Scott; Hunt, Louise

    2016-02-01

    Healthcare professionals are turning increasingly to the digital sector to access information they need for their work. Mobile technology, such as smartphones and tablets, provides a unique opportunity to place high-quality information directly into users' hands. This article describes the ongoing development of a smartphone app, Preparing for Caring, designed to prepare the future workforce by enabling mentors and nursing students to access supportive material during practice-based learning episodes. The article explores the rationale for designing the app and discusses the challenges and benefits of developing this resource from the perspectives of student, mentor and healthcare manager. PMID:26938912

  6. Gesundheit aus der Hosentasche? Chancen und Grenzen gesundheitsbezogener Apps

    OpenAIRE

    Enste, Peter; Merkel, Sebastian; Romanowski, Sascha

    2010-01-01

    Mehr als die Hälfte aller Bundesbürger (52,6 %) informiert sich inzwischen online über Gesundheitsthemen. 2011 wird voraussichtlich jedes dritte verkaufte Mobiltelefon ein Smartphone sein. Seit der Einführung des Online-Stores von Apple im Juli 2008 stehen mehr als 300.000 Anwendungen bereit, die bis Ende September über 7 Mrd. mal heruntergeladen wurden. In Deutschland stehen ca. 1400 gesundheitsbezogene Apps zur Verfügung, international sind es bereits über 7000. Health Apps spielen derzeit ...

  7. Best book on iOS app marketing

    CERN Document Server

    Amerson, Michael

    2012-01-01

    Mike Amerson, Co-Founder and President of WET Productions, Inc., learned the hard lesson that many developers face today: just because you built it, doesn't mean they will come. His game ""My Virtual Girlfriend"" went nine months with only modest sales until late in December of 2010, when he gathered what he'd learned about app discoverability and used it to propel the game to the Top 100 list for its category. Furthermore, the game has only gained momentum, sitting in the Top 25 for over a year. Though Mike overcame the challenges of app development, he knows exactly what it's like for a

  8. Google Script Adding Functionality to Your Google Apps

    CERN Document Server

    Ferreira, James

    2012-01-01

    How can you extend Google Apps to fit your organization's needs? This concise guide shows you how to use Google Scripts, the JavaScript-based language that provides a complete web-based development platform-with no downloads, configuration, or compiling required. You'll learn how to add functionality to Gmail, spreadsheets, and other Google services, or build data-driven apps that run from a spreadsheet, in a browser window, or within a Google Site. If you have some Java experience, getting started with Google Scripts is easy. Through code examples and step-by-step instructions, you'll learn

  9. Truncating mutations in APP cause a distinct neurological phenotype.

    Science.gov (United States)

    Klein, Steven; Goldman, Alexander; Lee, Hane; Ghahremani, Shahnaz; Bhakta, Viraj; Nelson, Stanley F; Martinez-Agosto, Julian A

    2016-09-01

    Dominant missense mutations in the amyloid β (Aβ) precursor protein (APP) gene have been implicated in early onset Alzheimer disease. These mutations alter protein structure to favor the pathologic production of Aβ. We report that homozygous nonsense mutations in APP are associated with decreased somatic growth, microcephaly, hypotonia, developmental delay, thinning of the corpus callosum, and seizures. We compare the phenotype of this case to those reported in mouse models and demonstrate multiple similarities, strengthening the role of amyloid precursor protein in normal brain function and development. Ann Neurol 2016;80:456-460. PMID:27422356

  10. Localizing apps a practical guide for translators and translation students

    CERN Document Server

    Roturier, Johann

    2015-01-01

    The software industry has undergone rapid development since the beginning of the twenty-first century. These changes have had a profound impact on translators who, due to the evolving nature of digital content, are under increasing pressure to adapt their ways of working. Localizing Apps looks at these challenges by focusing on the localization of software applications, or apps. In each of the five core chapters, Johann Roturier examines:The role of translation and other linguistic activities in adapting software to the needs of different cultures (localization);The procedures required to prep

  11. Field Geologist: An Android App for Measuring Rock Outcroppings

    Science.gov (United States)

    Baird, J.; Chiu, M. T.; Huang, X.; de Lanerolle, T. R.; Morelli, R.; Gourley, J. R.

    2011-12-01

    Field geologist is a mobile Android app that measures, plots, and exports strike and data in the field. When the phone is placed on the steepest part of the rock, it automatically detects dip, string, latitude and longitude. It includes a drop-down menu to record the type of rock. The app's initial screen displays a compass with an interior dip/strike symbol that always points toward the dip direction. Tapping the compass stores a data point in the phone's database. The points can be displayed on a Google map and uploaded to a server, from where they can be retrieved in CSV format and imported into a spreadsheet.

  12. Best iPad Apps The Guide for Discriminating Downloaders

    CERN Document Server

    Meyers, Peter

    2010-01-01

    What really wows iPad fans is when their touchscreen does what's impossible on other gadgets: the finger-painting app that turns a cross-country flight into a moving art class, the mini music studio (two-dozen instruments strong, each with motion-induced warble effects), and the portable fireworks display that you sculpt by swiping. Problem is, with tens of thousands of apps available for your iPad, who knows what to download? You can try to sort through a gazillion customer reviews with a mix of 5- and 1-star ratings, but that's a head-hurting time-waster. The stakes are getting higher, too

  13. 77 FR 52108 - Commercial Space Transportation Advisory Committee; Open Meeting

    Science.gov (United States)

    2012-08-28

    ... TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee; Open Meeting AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation... Act (Pub. L. 92-463, 5 U.S.C. App. 2), notice is hereby given of a meeting of the Commercial...

  14. NOAA Climate Data Record (CDR) of AVHRR Polar Pathfinder (APP) Cryosphere

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) contains the AVHRR Polar Pathfinder (APP) product. APP is a fundamental CDR comprised of calibrated and navigated AVHRR channel...

  15. The mitochondrial function was impaired in APP knockout mouse embryo fibroblast cells

    Institute of Scientific and Technical Information of China (English)

    SHENG BaiYang; NIU Ying; ZHOU Hui; YAN JiaXin; ZHAO NanMing; ZHANG XiuFang; GONG YanDao

    2009-01-01

    The amyloid precursor protein (APP) is recognized as the source of Aβ, which plays an important role in Alzheimer's disease. However, the biological function of APP is obscure. Previous studies showed that mitochondria could be a target of APP. In this work, APP knockout mouse embryo fibroblast (MEF) cells were used to test if APP plays any role in maintaining the mitochondrial function. As the result, APP knockout MEF cells (APP-/- cells) showed the abnormal mitochondrial function, including slower cell proliferation, lower mitochondrial membrane potential, lower intracellular ROS, higher mitochon-drial membrane fluidity and lower cytochrome c oxidase activity than their wild-type counterparts. However, no change was found in the amount of mitochondria in MEF APP-/- cells.

  16. How to start a home-based mobile app developer business

    CERN Document Server

    Brooks, Chad

    2014-01-01

    With the app market exploding, app designers will need a solid how-to guide to help them start their home-based business. This book will guide the reader through all the steps from design to marketing.

  17. Expert Involvement and Adherence to Medical Evidence in Medical Mobile Phone Apps

    DEFF Research Database (Denmark)

    Subhi, Yousif; Bube, Sarah Hjartbro; Rolskov Bojsen, Signe;

    2015-01-01

    BACKGROUND: Both clinicians and patients use medical mobile phone apps. Anyone can publish medical apps, which leads to contents with variable quality that may have a serious impact on human lives. We herein provide an overview of the prevalence of expert involvement in app development and whether...... or not app contents adhere to current medical evidence. OBJECTIVE: To systematically review studies evaluating expert involvement or adherence of app content to medical evidence in medical mobile phone apps. METHODS: We systematically searched 3 databases (PubMed, The Cochrane Library, and EMBASE......), and included studies evaluating expert involvement or adherence of app content to medical evidence in medical mobile phone apps. Two authors performed data extraction independently. Qualitative analysis of the included studies was performed. RESULTS: Based on inclusion criteria, 52 studies were included...

  18. Identification of different types of spinal afferent nerve endings that encode noxious and innocuous stimuli in the large intestine using a novel anterograde tracing technique.

    Directory of Open Access Journals (Sweden)

    Nick J Spencer

    Full Text Available In mammals, sensory stimuli in visceral organs, including those that underlie pain perception, are detected by spinal afferent neurons, whose cell bodies lie in dorsal root ganglia (DRG. One of the major challenges in visceral organs has been how to identify the different types of nerve endings of spinal afferents that transduce sensory stimuli into action potentials. The reason why spinal afferent nerve endings have been so challenging to identify is because no techniques have been available, until now, that can selectively label only spinal afferents, in high resolution. We have utilized an anterograde tracing technique, recently developed in our laboratory, which facilitates selective labeling of only spinal afferent axons and their nerve endings in visceral organs. Mice were anesthetized, lumbosacral DRGs surgically exposed, then injected with dextran-amine. Seven days post-surgery, the large intestine was removed. The characteristics of thirteen types of spinal afferent nerve endings were identified in detail. The greatest proportion of nerve endings was in submucosa (32%, circular muscle (25% and myenteric ganglia (22%. Two morphologically distinct classes innervated myenteric ganglia. These were most commonly a novel class of intraganglionic varicose endings (IGVEs and occasionally rectal intraganglionic laminar endings (rIGLEs. Three distinct classes of varicose nerve endings were found to innervate the submucosa and circular muscle, while one class innervated internodal strands, blood vessels, crypts of lieberkuhn, the mucosa and the longitudinal muscle. Distinct populations of sensory endings were CGRP-positive. We present the first complete characterization of the different types of spinal afferent nerve endings in a mammalian visceral organ. The findings reveal an unexpectedly complex array of different types of primary afferent endings that innervate specific layers of the large intestine. Some of the novel classes of nerve endings

  19. Identification of Different Types of Spinal Afferent Nerve Endings That Encode Noxious and Innocuous Stimuli in the Large Intestine Using a Novel Anterograde Tracing Technique

    Science.gov (United States)

    Spencer, Nick J.; Kyloh, Melinda; Duffield, Michael

    2014-01-01

    In mammals, sensory stimuli in visceral organs, including those that underlie pain perception, are detected by spinal afferent neurons, whose cell bodies lie in dorsal root ganglia (DRG). One of the major challenges in visceral organs has been how to identify the different types of nerve endings of spinal afferents that transduce sensory stimuli into action potentials. The reason why spinal afferent nerve endings have been so challenging to identify is because no techniques have been available, until now, that can selectively label only spinal afferents, in high resolution. We have utilized an anterograde tracing technique, recently developed in our laboratory, which facilitates selective labeling of only spinal afferent axons and their nerve endings in visceral organs. Mice were anesthetized, lumbosacral DRGs surgically exposed, then injected with dextran-amine. Seven days post-surgery, the large intestine was removed. The characteristics of thirteen types of spinal afferent nerve endings were identified in detail. The greatest proportion of nerve endings was in submucosa (32%), circular muscle (25%) and myenteric ganglia (22%). Two morphologically distinct classes innervated myenteric ganglia. These were most commonly a novel class of intraganglionic varicose endings (IGVEs) and occasionally rectal intraganglionic laminar endings (rIGLEs). Three distinct classes of varicose nerve endings were found to innervate the submucosa and circular muscle, while one class innervated internodal strands, blood vessels, crypts of lieberkuhn, the mucosa and the longitudinal muscle. Distinct populations of sensory endings were CGRP-positive. We present the first complete characterization of the different types of spinal afferent nerve endings in a mammalian visceral organ. The findings reveal an unexpectedly complex array of different types of primary afferent endings that innervate specific layers of the large intestine. Some of the novel classes of nerve endings identified

  20. Mobile medical and health apps: state of the art, concerns, regulatory control and certification.

    Science.gov (United States)

    Boulos, Maged N Kamel; Brewer, Ann C; Karimkhani, Chante; Buller, David B; Dellavalle, Robert P

    2014-01-01

    This paper examines the state of the art in mobile clinical and health-related apps. A 2012 estimate puts the number of health-related apps at no fewer than 40,000, as healthcare professionals and consumers continue to express concerns about the quality of many apps, calling for some form of app regulatory control or certification to be put in place. We describe the range of apps on offer as of 2013, and then present a brief survey of evaluation studies of medical and health-related apps that have been conducted to date, covering a range of clinical disciplines and topics. Our survey includes studies that highlighted risks, negative issues and worrying deficiencies in existing apps. We discuss the concept of 'apps as a medical device' and the relevant regulatory controls that apply in USA and Europe, offering examples of apps that have been formally approved using these mechanisms. We describe the online Health Apps Library run by the National Health Service in England and the calls for a vetted medical and health app store. We discuss the ingredients for successful apps beyond the rather narrow definition of 'apps as a medical device'. These ingredients cover app content quality, usability, the need to match apps to consumers' general and health literacy levels, device connectivity standards (for apps that connect to glucometers, blood pressure monitors, etc.), as well as app security and user privacy. 'Happtique Health App Certification Program' (HACP), a voluntary app certification scheme, successfully captures most of these desiderata, but is solely focused on apps targeting the US market. HACP, while very welcome, is in ways reminiscent of the early days of the Web, when many "similar" quality benchmarking tools and codes of conduct for information publishers were proposed to appraise and rate online medical and health information. It is probably impossible to rate and police every app on offer today, much like in those early days of the Web, when people

  1. Essays on the Mobile App Platform Choice and Firm Innovation Disclosure

    OpenAIRE

    Liu, Yongdong

    2015-01-01

    This dissertation combines two papers on industrial organizations and innovations. The first paper focuses on the market evolution in the mobile app platform and the second paper is an empirical study on firm's innovation disclosure and its impact on firm's intellectual property management. Chapter 1 studies mobile app's platform choice decisions. Ever since Apple and Google launched their mobile application (app) stores in 2008, the market for mobile apps has experienced rapid growth and rep...

  2. There’s an App for That? Highlighting the Difficulty in Finding Clinically Relevant Smartphone Applications

    OpenAIRE

    Warren Wiechmann, MD, MBA; Daniel Kwan, MD; Andrew Bokarius, MD; Shannon L. Toohey, MD

    2016-01-01

    Introduction: The use of personal mobile devices in the medical field has grown quickly, and a large proportion of physicians use their mobile devices as an immediate resource for clinical decision-making, prescription information and other medical information. The iTunes App Store (Apple, Inc.) contains approximately 20,000 apps in its “Medical” category, providing a robust repository of resources for clinicians; however, this represents only 2% of the entire App Store. The App Store does no...

  3. Adherence to evidence-based guidelines among diabetes self-management apps

    OpenAIRE

    Jessica Y. Breland; Yeh, Vivian M.; Yu, Jessica

    2013-01-01

    Smartphone apps can provide real-time, interactive self-management aid to individuals with diabetes. It is currently unclear whether existing diabetes self-management apps follow evidence-based guidelines. The purpose of this study was to evaluate the extent to which existing diabetes self-management apps address the seven self-management behaviors recommended by the American Association of Diabetes Educators (the AADE7™). The term “diabetes” identified relevant self-management apps via the A...

  4. Who Uses Smoking Cessation Apps? A Feasibility Study Across Three Countries via Smartphones

    OpenAIRE

    BinDhim, Nasser F; McGeechan, Kevin; Trevena, Lyndal

    2014-01-01

    Background Smartphone use is growing worldwide. While hundreds of smoking cessation apps are currently available in the app stores, there is no information about who uses them. Smartphones also offer potential as a research tool, but this has not previously been explored. Objective This study aims to measure and compare the uptake of a smoking cessation app over one year in Australia, the United Kingdom, and the United States. It also assesses the feasibility of conducting research via an app...

  5. Designing the online oral language learning environment SpeakApps

    NARCIS (Netherlands)

    Nic Giolla Mhichíl, Mairéad; Appel, Christine; Ó Ciardubháin, Colm; Jager, Sake; Prizel-Kania, Adriana

    2015-01-01

    Purpose – The purpose of this paper is to report on SpeakApps, a major collaborative computer-assisted language learning project, developed based on an open source techno-pedagogical solution to facilitate online oral language production and interaction. Design/methodology/approach – A mixed method

  6. Best book on finding & developing your Android app idea

    CERN Document Server

    Kim, Eddie

    2011-01-01

    Android can seem intimidating, if not downright overwhelming, for a first time developer. In ""The Best Book On Finding & Developing Your Android App Idea"", Edward Kim walks Android rookies through the process, from conceptualization straight through to the Android market, helping them through the basics so they can get right down to what's important to their application.

  7. MyShake - A smartphone app to detect earthquake

    Science.gov (United States)

    Kong, Q.; Allen, R. M.; Schreier, L.; Kwon, Y. W.

    2015-12-01

    We designed an android app that harnesses the accelerometers in personal smartphones to record earthquake-shaking data for research, hazard information and warnings. The app has the function to distinguish earthquake shakings from daily human activities based on the different patterns behind the movements. It also can be triggered by the traditional earthquake early warning (EEW) system to record for a certain amount of time to collect earthquake data. When the app is triggered by the earthquake-like movements, it sends the trigger information back to our server which contains time and location of the trigger, at the same time, it stores the waveform data on local phone first, and upload to our server later. Trigger information from multiple phones will be processed in real time on the server to find the coherent signal to confirm the earthquakes. Therefore, the app provides the basis to form a smartphone seismic network that can detect earthquake and even provide warnings. A planned public roll-out of MyShake could collect millions of seismic recordings for large earthquakes in many regions around the world.

  8. Developing mobile educational apps: development strategies, tools and business models

    Directory of Open Access Journals (Sweden)

    Serena Pastore

    Full Text Available The mobile world is a growing and evolving market in all its aspects from hardware, networks, operating systems and applications. Mobile applications or apps are becoming the new frontier of software development, since actual digital users use mobile devi ...

  9. Mobile Devices and Apps as Accelerators for OER

    NARCIS (Netherlands)

    De Vries, Fred; Thuss, Frank

    2013-01-01

    De Vries, F., & Thuss, F. (2013). Mobile Devices and Apps as accelerators for OER. In R. Jacobi, H. Jelgerhuis, & N. Van der Woert (Eds.), Trendreport Open Educational Resources 2013 (pp. 49-52). Utrecht: SURF Foundation - Special Interest Group Open Educational Resources SURF.

  10. There's an APP for That

    Science.gov (United States)

    Bowen, Bradley; Finch, James

    2014-01-01

    This article describes how one science teacher based an activity on designing smartphone apps to clearly and concisely communicate the interdependent relationships of a biological ecosystem. The teacher designed the activity to address several aspects of the latest science standards. Students needed to understand their ecosystem and synthesize new…

  11. Shaking up Expectations: The OCLS Shake It! App

    Science.gov (United States)

    Shivers, Cassandra

    2012-01-01

    The author, a digital access architect in the information systems department of the Orange County Library System in Florida, was given the challenge of creating a library mobile app around the 2009 holiday season. At that time, Sheri Chambers, digital content manager in the information systems department, and Debbie Moss, assistant director of the…

  12. Portable Desktop Apps with GitHub Electron

    CERN Document Server

    CERN. Geneva

    2016-01-01

    Wouldn't it be nice if you could develop applications that work everywhere, regardless of Operating System or Platform? Even better, what if you could employ the same front-end technologies you use for your web/mobile apps? Meet GitHub Electron.

  13. Exploring Mobile Apps for English Language Teaching and Learning

    Science.gov (United States)

    Zou, Bin; Li, Jiaying

    2015-01-01

    Many recent studies have shown that mobile learning can provide potential possibilities for foreign language learners to practice language skills on their smart mobile phones and tablet PCs (e.g. Chang & Hsu, 2011; Egbert, Akasha, Huff, & Lee, 2011; Hoven & Palalas, 2011; Stockwell, 2010). A number of apps have been created and used…

  14. Apps for Physical Education: Teacher Tested, Kid Approved!

    Science.gov (United States)

    Phillips, Amber; Rodenbeck, Myshel; Clegg, Bethany

    2014-01-01

    Physical education teachers have been encouraged to use technology in their classes to enhance student motivation and learning. The purpose of this article is to share iOS applications (apps) that K-12 physical education teachers and students have found useful.

  15. Effects of Using an Ipod App to Manage Recreation Tasks

    Science.gov (United States)

    Uphold, Nicole M.; Douglas, Karen H.; Loseke, Dannell L.

    2016-01-01

    A withdrawal design study evaluated the effectiveness of using constant time delay to teach six adults with a developmental disability to program and use an iPod touch® as an electronic photographic activity schedule (ePAS). The ePAS, created with the First Then Visual Schedule app, consisted of photographs of different exercises to complete…

  16. Tree Height Calculator: An Android App for Estimating Tree Height

    Science.gov (United States)

    Burca, V. S.; Htet, N. M.; Huang, X.; de Lanerolle, T. R.; Morelli, R.; Gourley, J. R.

    2011-12-01

    Conventionally, measuring tree height requires a collection of different tools - clinometer, transit, pencil, paper, laptop computer. Results are recorded manually and entered into a spreadsheet or database for future calculation and analysis. Tree Height Calculator is a mobile Android app the integrates the various steps in this process thereby improving the accuracy and dramatically reducing the time required to go from taking measurements to analyzing data. Given the user's height and the distance from the base of the tree (which can be downloaded into the app from a server), the app uses the phone's orientation sensor to calculate the angle of elevation. A simple trigonometric formula is then used to calculate and record the tree's height in the phone's database. When the phone has a WiFi connection, the data are transmitted to a server, from where they can be downloaded directly into a spreadsheet. The application was first tested in an Environmental Science laboratory at Trinity College. On the first trial, 103 data samples were collected, stored, and uploaded to the online database with only couple of dropped data points. On the second trial, 98 data samples were gathered with no loss of data. The app combined the individual measurements taken by the students in the lab, reducing the time required to produce a graph of the class's results from days to hours.

  17. Mobiele apparaten en apps als versnellers van Open Educational Resources

    NARCIS (Netherlands)

    De Vries, Fred; Thuss, Frank

    2013-01-01

    De Vries, F., & Thuss, F. (2013). Mobiele apparaten en apps als versnellers van Open Educational Resources? In R. Jacobi, H. Jelgerhuis, & N. van der Woert (Eds.), Trendrapport Open Educational Resources 2013 (pp. 51-54). Utrecht: SURF Foundation - Special Interest Group Open Educational Resources S

  18. CERN@school: a new app displays natural radiation data

    CERN Multimedia

    Julio Rosenfeld

    2012-01-01

    A student from the Simon Langton Grammar School for Boys in Kent (UK) has developed an app that displays data recorded by Medipix chips. Created for Android-based devices, the app is a new way for students to visualize the natural radiation in their local area.   James Hurst shows off the Medipix chips at his school's stand at the UK's Royal Society Summer Science Exhibition. James Hurst, 17, developed the app in the framework of the CERN@school project that Becky Parker, a former participant in CERN’s High School Teachers (HST) programme, set up in 2008. “The app is able to display pre-recorded data in both graphic and numeric formats,” explains James. “I am already envisaging further developments, which might include producing the iOS version and eventually a live data-taking system.” CLEAR (Comprehensive Langton Evaluation and Analysis of Radiation), as it is named, will soon be available free from the Android Market toget...

  19. Apps. Accessibility and Usability by People with Visual Disabilities

    Science.gov (United States)

    Olmedo-Moreno, Eva María; López-Delgado, Adrian

    2015-01-01

    The increasing use of ICT devices, such as smartphones and tablets, needs development of properly software or apps to facilitate socio-educative life of citizens in smart cities: Adaptive educational resources, leisure and entertainment facilities or mobile payment services, among others. Undoubtedly, all that is opening a new age with more…

  20. Adherence to evidence-based guidelines among diabetes self-management apps.

    Science.gov (United States)

    Breland, Jessica Y; Yeh, Vivian M; Yu, Jessica

    2013-09-01

    Smartphone apps can provide real-time, interactive self-management aid to individuals with diabetes. It is currently unclear whether existing diabetes self-management apps follow evidence-based guidelines. The purpose of this study was to evaluate the extent to which existing diabetes self-management apps address the seven self-management behaviors recommended by the American Association of Diabetes Educators (the AADE7™). The term "diabetes" identified relevant self-management apps via the Apple App Store search engine in March 2012. Ratings were based on app descriptions and downloads. Chi-square analyses assessed differences in apps based on developer type. Apps promoted a median of two AADE7™ skills. Overall reliability between description and download ratings was good (kappa = .66). Reliability of individual skills was variable (kappa = .25 to .91). Most diabetes apps do not conform to evidence-based recommendations, and future app reviews would benefit from testing app performance. Future apps may also benefit from theory-based designs. PMID:24073179

  1. Moving Phones Tick Slower: Creating an Android App to Demonstrate Time Dilation

    Science.gov (United States)

    Underwood, Bret; Zhai, Yunxiao

    2016-05-01

    Smartphones and tablets are packed with sensors that allow us to take experimental data, essentially making them mobile physics labs. Apps exist that make it easy to capture and analyze data from these sensors, allowing users to study diverse phenomena such as free fall acceleration, the speed of sound, radioactivity, and many others. Commonly, the use of apps in the physics classroom focuses on existing apps rather than on the creation of apps themselves. This is for a good reason-writing an app usually requires advanced knowledge of programming languages and experience with app design. These skills are generally regarded as beyond the typical physics student. However, there are app development environments, such as MIT App Inventor 2 for Android, which make the process of creating an app and utilizing the sensors much more accessible to students. Putting the ability to create and configure apps within the reach of students can also help integrate computation into the curriculum. In this article, we discuss our creation of an Android app, Time Dilation Calculator, done as part of a senior undergraduate capstone project, which uses App Inventor and a mobile device's global positioning system (GPS) receiver to calculate the time dilation effect of special relativity.

  2. Rheumabuddy, a smartphone app, used to empower patients with rheumatoid arthritis

    DEFF Research Database (Denmark)

    Rickmann, J.; Schiottz-Christensen, B.; Dam, A.

    2015-01-01

    . RheumaBuddy is an app focused on achievement of self-empowerment. Through the app patients gets a better overview of the actual status of their disease, discovering patterns and getting hints to change their daily activities in a positive direction. The app has been developed in a joint-venture...

  3. SpeakApps 2: Speaking Practice in a Foreign Language through ICT Tools

    Science.gov (United States)

    Appel, Christine; Nic Giolla Mhichíl, Mairéad; Jager, Sake; Prizel-Kania, Adriana

    2014-01-01

    SpeakApps 2 is a project with support of the Lifelong Learning Programme, Accompanying Measures. It follows up on the work and results reached during the KA2 project "SpeakApps: Oral production and interaction in a foreign language through ICT tools". The overarching aim of SpeakApps 2 is to further enhance Europeans' language learning…

  4. 77 FR 72864 - Announcement of Requirements and Registration for healthfinder.gov Mobile App Challenge

    Science.gov (United States)

    2012-12-06

    ... HUMAN SERVICES Announcement of Requirements and Registration for healthfinder.gov Mobile App Challenge... Disease Prevention and Health Promotion (ODPHP) is launching a healthfinder.gov Mobile App Challenge to promote the development of a mobile app that will facilitate the customized use of prevention and...

  5. Variability Handling for Mobile Banking Apps on iOS and Android

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Jørgensen, Jens Bæk; Knudsen, Bjarne;

    2016-01-01

    During the last four years, Mjølner Informatics has developed mobile banking apps for 11 different Danish banks on the two major platforms iOS and Android, in total 22 apps. We make two contributions with this industrial practice paper. In the first place, we describe the development of these apps...

  6. A Detailed Rubric for Assessing the Quality of Teacher Resource Apps

    Science.gov (United States)

    Cherner, Todd; Lee, Cheng-Yuan; Fegely, Alex; Santaniello, Lauren

    2016-01-01

    Since the advent of the iPhone and rise of mobile technologies, educational apps represent one of the fastest growing markets, and both the mobile technology and educational app markets are predicted to continue experiencing growth into the foreseeable future. The irony, however, is that even with a booming market for educational apps, very little…

  7. SoilInfo App: global soil information on your palm

    Science.gov (United States)

    Hengl, Tomislav; Mendes de Jesus, Jorge

    2015-04-01

    ISRIC ' World Soil Information has released in 2014 and app for mobile de- vices called 'SoilInfo' (http://soilinfo-app.org) and which aims at providing free access to the global soil data. SoilInfo App (available for Android v.4.0 Ice Cream Sandwhich or higher, and Apple v.6.x and v.7.x iOS) currently serves the Soil- Grids1km data ' a stack of soil property and class maps at six standard depths at a resolution of 1 km (30 arc second) predicted using automated geostatistical mapping and global soil data models. The list of served soil data includes: soil organic carbon (), soil pH, sand, silt and clay fractions (%), bulk density (kg/m3), cation exchange capacity of the fine earth fraction (cmol+/kg), coarse fragments (%), World Reference Base soil groups, and USDA Soil Taxonomy suborders (DOI: 10.1371/journal.pone.0105992). New soil properties and classes will be continuously added to the system. SoilGrids1km are available for download under a Creative Commons non-commercial license via http://soilgrids.org. They are also accessible via a Representational State Transfer API (http://rest.soilgrids.org) service. SoilInfo App mimics common weather apps, but is also largely inspired by the crowdsourcing systems such as the OpenStreetMap, Geo-wiki and similar. Two development aspects of the SoilInfo App and SoilGrids are constantly being worked on: Data quality in terms of accuracy of spatial predictions and derived information, and Data usability in terms of ease of access and ease of use (i.e. flexibility of the cyberinfrastructure / functionalities such as the REST SoilGrids API, SoilInfo App etc). The development focus in 2015 is on improving the thematic and spatial accuracy of SoilGrids predictions, primarily by using finer resolution covariates (250 m) and machine learning algorithms (such as random forests) to improve spatial predictions.

  8. Beyond WhatsApp: Older people and smartphones

    Directory of Open Access Journals (Sweden)

    Andrea Rosales

    2016-06-01

    Full Text Available This paper analyzes how older people, living in Spain, use smartphones and smartphone applications. Using a mixed methods approach, we compare quantitative results obtained by tracking mobile app usage amongst different generational samples with qualitative, focus-group discussions with active smartphone users. A sample of Spanish smartphone users were tracked during one month in the winter of 2014 (238 individuals, aged 20 to 76 years-old. This was followed by three focus group sessions conducted in the spring of 2015, with 24 individuals aged 55 to 81. As we learned, WhatsApp is currently the most popular application used by people of all ages, including older adults. Smartphones increasingly are playing a central role in the life of older participants, although the frequency of app access is negatively correlated with age. On the other hand, as our data indicates, older adults also use a number of different types of apps that are distinct from that of younger users. Older participants access personal information manager apps (calendar, address book and notes more often than other age groups. And comparatively, older participants use the smartphone less often in stable locations (home, office, relatives’ home with Wifi than somewhere else and with mobile data. As we argue, differences in age seem to reflect the evolution in personal interests and communication patterns that change as we grow older. Our study captures new trends in smartphone usage amongst this cohort. It also indicates how a combination of methods may help to assess the validity of the log and qualitative data. We highlight the relevance of conducting careful generational studies in smartphone use and some of the potentials and limitations of making predictive studies of ICT use as we change throughout the life course. Finally, we assert the value of the inclusion of older representatives within research, which ultimately may influence public decisions and the design of new

  9. Diabetes Applications for Arabic Speakers: A Critical Review of Available Apps for Android and iOS Operated Smartphones.

    Science.gov (United States)

    Alhuwail, Dari

    2016-01-01

    Today, 415 million adults have diabetes; more than 35 million of diabetic adults live in the Middle East and North Africa region. Smartphone penetration in the region is high and applications, or apps, for diabetics have shown promising results in recent years. This study took place between September and December 2015 and reviewed all currently available smartphone diabetes apps for Arabic speakers in both the Apple App and Google Play stores. There were only few diabetes apps for Arabic speakers; only eighteen apps were discovered and considered for this study. Most apps were informational. Only three apps offered utilities such as glucose reading conversion. The apps had issues related to information quality and adherence to latest evidence-based medical advice. There is a need for more evidence-based Arabic diabetes apps with improved functionality. Future research of Arabic diabetes apps should also focus on the involvement and engagement of the patients in the design of these apps.

  10. Diabetes Applications for Arabic Speakers: A Critical Review of Available Apps for Android and iOS Operated Smartphones.

    Science.gov (United States)

    Alhuwail, Dari

    2016-01-01

    Today, 415 million adults have diabetes; more than 35 million of diabetic adults live in the Middle East and North Africa region. Smartphone penetration in the region is high and applications, or apps, for diabetics have shown promising results in recent years. This study took place between September and December 2015 and reviewed all currently available smartphone diabetes apps for Arabic speakers in both the Apple App and Google Play stores. There were only few diabetes apps for Arabic speakers; only eighteen apps were discovered and considered for this study. Most apps were informational. Only three apps offered utilities such as glucose reading conversion. The apps had issues related to information quality and adherence to latest evidence-based medical advice. There is a need for more evidence-based Arabic diabetes apps with improved functionality. Future research of Arabic diabetes apps should also focus on the involvement and engagement of the patients in the design of these apps. PMID:27332269

  11. How to Find Good Apps: An Evaluation Rubric for Instructional Apps for Teaching Students with Learning Disabilities

    Science.gov (United States)

    Ok, Min Wook; Kim, Min Kyung; Kang, Eun Young; Bryant, Brian R.

    2016-01-01

    Computers can be an effective teaching method for students with learning disabilities (LD). The use of mobile devices as education tools for students with disabilities has received considerable attention in special education recently. Parents, teachers, and professionals look for effective applications (i.e., apps) that meet the needs of their…

  12. DroidLink: Automated Generation of Deep Links for Android Apps

    OpenAIRE

    Ma, Yun; Liu, Xuanzhe; Du, Ruogu; Hu, Ziniu; Liu, Yi; Yu, Meihua; Huang, Gang

    2016-01-01

    The mobile application (app) has become the main entrance to access the Internet on handheld devices. Unlike the Web where each webpage has a global URL to reach directly, a specific "content page" of an app can be opened only by exploring the app with several operations from the landing page. The interoperability between apps is quite fixed and thus limits the value-added "linked data" between apps. Recently, deep link has been proposed to enable targeting and opening a specific page of an a...

  13. Instant Passbook app development for iOS how-to

    CERN Document Server

    Moon, Keith D

    2013-01-01

    Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. A step-by-step guide, focusing on simple projects to help you create a Passbook app for iOS 6.Instant Passbook App Development for iOS 6 How-to is for registered Apple iOS developers, experienced in building an app using Objective-C and Xcode, looking to add Passbook functionality to their app. You will need to have an understanding of the JSON format, REST APIs, and a server-side language like Ruby. Familiarity with executing commands via the Terminal app is expected for the exerci

  14. Biochemical analysis of PIFTC3, the Trypanosoma brucei ortholog of nematode DYF-13, reveals interactions with established and putative intraflagellar transport components

    OpenAIRE

    Franklin, Joseph B.; Ullu, Elisabetta

    2010-01-01

    DYF-13, originally identified in C. elegans within a collection of dye-filling chemosensory mutants, is one of several proteins that have been classified as putatively involved in intraflagellar transport (IFT), the bidirectional movement of protein complexes along cilia and flagella, and specifically in anterograde IFT. Although genetic studies have highlighted a fundamental role of DYF-13 in nematode sensory cilium and trypanosome flagellum biogenesis, biochemical studies on DYF-13 have lag...

  15. 76 FR 6841 - ITS Joint Program Office; Intelligent Transportation Systems Program Advisory Committee; Notice...

    Science.gov (United States)

    2011-02-08

    ... TRANSPORTATION ITS Joint Program Office; Intelligent Transportation Systems Program Advisory Committee; Notice of... (FACA) (Pub. L. 72-363; 5 U.S.C. app. 2), a meeting of the Intelligent Transportation Systems (ITS... study, development, and implementation of intelligent transportation systems. Through its sponsor,...

  16. Do Arabic weight-loss apps adhere to evidence-informed practices?

    Science.gov (United States)

    Alnasser, Aroub A; Amalraj, Raja E; Sathiaseelan, Arjuna; Al-Khalifa, Abdulrahman S; Marais, Debbi

    2016-09-01

    Mobile technology has been used successfully for promoting health and weight loss and for treating obesity. There is a high prevalence of smartphone and tablet users among the Saudi population. This study aimed to identify whether current Arabic weight-loss apps had features that adhered to evidence-informed practices. The six most relevant app stores were systematically searched using the Arabic words for weight and diet (n = 298). All apps that met the inclusion criteria (n = 65) were downloaded and examined for adherence to 13 evidence-informed practices. Latent class analysis identified two subgroups of apps: self-monitoring (15 % of apps) and advice-giving apps (85 %). The median number of evidence-informed practices was 1 (1, 2), with no apps having more than six and only nine apps including four to six. Meal planning was the most common feature (38 % of apps). These findings identify serious weaknesses in the currently available Arabic weight-loss apps. Thus, existing and future apps should include more features based on the best available evidence in the context of Arab culture. PMID:27528528

  17. Mobile App Design for Teaching and Learning: Educators’ Experiences in an Online Graduate Course

    Directory of Open Access Journals (Sweden)

    Yu-Chang Hsu

    2013-09-01

    Full Text Available This research explored how educators with limited programming experiences learned to design mobile apps through peer support and instructor guidance. Educators were positive about the sense of community in this online course. They also considered App Inventor a great web-based visual programming tool for developing useful and fully functioning mobile apps. They had great sense of empowerment through developing unique apps by using App Inventor. They felt their own design work and creative problem solving were inspired by the customized mobile apps shared by peers. The learning activities, including sharing customized apps, providing peer feedback, composing design proposals, and keeping design journals (blogging, complemented each other to support a positive sense of community and form a strong virtual community of learning mobile app design. This study helped reveal the educational value of mobile app design activities and the web-based visual programming tool, and the possibility of teaching/learning mobile app design online. The findings can also encourage educators to explore and experiment on the potential of incorporating these design learning activities in their respective settings, and to develop mobile apps for their diverse needs in teaching and learning.

  18. Investigating the Potential of Activity Tracking App Data to Estimate Cycle Flows in Urban Areas

    Science.gov (United States)

    Haworth, J.

    2016-06-01

    Traffic congestion and its associated environmental effects pose a significant problem for large cities. Consequently, promoting and investing in green travel modes such as cycling is high on the agenda for many transport authorities. In order to target investment in cycling infrastructure and improve the experience of cyclists on the road, it is important to know where they are. Unfortunately, investment in intelligent transportation systems over the years has mainly focussed on monitoring vehicular traffic, and comparatively little is known about where cyclists are on a day to day basis. In London, for example, there are a limited number of automatic cycle counters installed on the network, which provide only part of the picture. These are supplemented by surveys that are carried out infrequently. Activity tracking apps on smart phones and GPS devices such as Strava have become very popular over recent years. Their intended use is to track physical activity and monitor training. However, many people routinely use such apps to record their daily commutes by bicycle. At the aggregate level, these data provide a potentially rich source of information about the movement and behaviour of cyclists. Before such data can be relied upon, however, it is necessary to examine their representativeness and understand their potential biases. In this study, the flows obtained from Strava Metro (SM) are compared with those obtained during the 2013 London Cycle Census (LCC). A set of linear regression models are constructed to predict LCC flows using SM flows along with a number of dummy variables including road type, hour of day, day of week and presence/absence of cycle lane. Cross-validation is used to test the fitted models on unseen LCC sites. SM flows are found to be a statistically significant (p<0.0001) predictor of total flows as measured by the LCC and the models yield R squared statistics of ~0.7 before considering spatio-temporal variation. The initial results indicate

  19. INVESTIGATING THE POTENTIAL OF ACTIVITY TRACKING APP DATA TO ESTIMATE CYCLE FLOWS IN URBAN AREAS

    Directory of Open Access Journals (Sweden)

    J. Haworth

    2016-06-01

    Full Text Available Traffic congestion and its associated environmental effects pose a significant problem for large cities. Consequently, promoting and investing in green travel modes such as cycling is high on the agenda for many transport authorities. In order to target investment in cycling infrastructure and improve the experience of cyclists on the road, it is important to know where they are. Unfortunately, investment in intelligent transportation systems over the years has mainly focussed on monitoring vehicular traffic, and comparatively little is known about where cyclists are on a day to day basis. In London, for example, there are a limited number of automatic cycle counters installed on the network, which provide only part of the picture. These are supplemented by surveys that are carried out infrequently. Activity tracking apps on smart phones and GPS devices such as Strava have become very popular over recent years. Their intended use is to track physical activity and monitor training. However, many people routinely use such apps to record their daily commutes by bicycle. At the aggregate level, these data provide a potentially rich source of information about the movement and behaviour of cyclists. Before such data can be relied upon, however, it is necessary to examine their representativeness and understand their potential biases. In this study, the flows obtained from Strava Metro (SM are compared with those obtained during the 2013 London Cycle Census (LCC. A set of linear regression models are constructed to predict LCC flows using SM flows along with a number of dummy variables including road type, hour of day, day of week and presence/absence of cycle lane. Cross-validation is used to test the fitted models on unseen LCC sites. SM flows are found to be a statistically significant (p<0.0001 predictor of total flows as measured by the LCC and the models yield R squared statistics of ~0.7 before considering spatio-temporal variation. The initial

  20. Current Status and Quality Assessment of Cardiovascular Diseases Related Smartphone Apps in China.

    Science.gov (United States)

    Xiao, Qian; Wang, Yanling; Sun, Liu; Lu, Sai; Wu, Ying

    2016-01-01

    To examine current status and quality of CVD related apps available for download in China, a total of 151 apps from the top popular six app stores were analyzed. Data analysis uncovered a range of issues including missing of key variables in the pre-formatted daily records, no platform for interaction with relevant healthcare professionals and undesirable user-interface design. More importantly, these apps had low levels of adherence to internationally recognized guidelines in CVD management. Overall quality score of these apps was below the average (8.08/20). This study identified areas for improvement concerning the existing CVD related apps. Information may guide the further advancement of CVD related apps and benefit CVD management in China. PMID:27332467

  1. Geosocial Networking App Use Among Men Who Have Sex With Men in Serious Romantic Relationships.

    Science.gov (United States)

    Macapagal, Kathryn; Coventry, Ryan; Puckett, Jae A; Phillips, Gregory; Mustanski, Brian

    2016-08-01

    Geosocial networking (GSN) mobile phone applications ("apps") are used frequently among men who have sex with men (MSM) to socialize and meet sexual partners. Though GSN apps are used by some MSM in partnered relationships, little is known about how the use of GSN apps among MSM in serious romantic relationships can influence couples' sexual and relationship health. MSM in serious relationships (N = 323; M age = 40 years) were recruited through a popular GSN app for MSM. Participants completed open-ended items regarding the costs and benefits of app use to their relationships, discussions of app use with their partners, and preferences for relationship education related to app use. Reported benefits of app use included improving sex and communication with one's primary partner and fulfilling unmet sexual needs. Although approximately half had not discussed app use with their partners, citing app use as a "non-issue," many cited various drawbacks to app use, including jealousy and being a distraction from the relationship. Few described sexual health concerns as a drawback to meeting partners through apps. Regarding relationship education preferences, most wanted help with general communication skills and how to express one's sexual needs to a partner. Although GSN app use can enhance relationships and sex among partnered MSM, unclear communication about app use may contribute to negative relationship outcomes and could prevent partners from having sexual needs met. Relationship and sexual health education programs for male couples should consider addressing social media and technology use in their curricula. PMID:26969319

  2. Apps for asthma self-management: a systematic assessment of content and tools

    Directory of Open Access Journals (Sweden)

    Huckvale Kit

    2012-11-01

    Full Text Available Abstract Background Apps have been enthusiastically adopted by the general public. They are increasingly recognized by policy-makers as a potential medium for supporting self-management of long-term conditions. We assessed the degree to which current smartphone and tablet apps for people with asthma offer content and tools of appropriate quality to support asthma self-management. Methods We adapted systematic review methodology to the assessment of apps. We identified English-language asthma apps for all ages through a systematic search of official app stores. We systematically assessed app content using criteria derived from international guidelines and systematic review of strategies for asthma self-management. We covered three domains: comprehensiveness of asthma information, consistency of advice with evidence and compliance with health information best practice principles. Results We identified 103 apps for asthma in English, of which 56 were sources of information about the condition and 47 provided tools for the management of asthma. No apps offered both types of functionality. Only three information apps approached our definition of comprehensiveness of information about asthma. No apps provided advice on lay management of acute asthma that included details of appropriate reliever medication use. In 32 of 72 instances, apps made unequivocal recommendations about strategies for asthma control or prophylaxis that were unsupported by current evidence. Although 90% of apps stated a clear purpose, compliance with other best practice principles for health information was variable. Contact details were located for 55%, funding source for 18% and confidentiality policy for 17%. Conclusions No apps for people with asthma combined reliable, comprehensive information about the condition with supportive tools for self-management. Healthcare professionals considering recommending apps to patients as part of asthma self-management should exercise

  3. Building iPhone Apps with HTML, CSS, and JavaScript Making App Store Apps Without Objective-C or Cocoa

    CERN Document Server

    Stark, Jonathan

    2010-01-01

    What people are saying about Building iPhone Apps w/ HTML, CSS, and JavaScript "The future of mobile development is clearly web technologies like CSS, HTML and JavaScript. Jonathan Stark shows you how to leverage your existing web development skills to build native iPhone applications using these technologies." --John Allsopp, author and founder of Web Directions "Jonathan's book is the most comprehensive documentation available for developing web applications for mobile Safari. Not just great tech coverage, this book is an easy read of purely fascinating mobile tidbits in a fun colloquial

  4. Sound level measurements using smartphone "apps": useful or inaccurate?

    Science.gov (United States)

    Nast, Daniel R; Speer, William S; Le Prell, Colleen G

    2014-01-01

    Many recreational activities are accompanied by loud concurrent sounds and decisions regarding the hearing hazards associated with these activities depend on accurate sound measurements. Sound level meters (SLMs) are designed for this purpose, but these are technical instruments that are not typically available in recreational settings and require training to use properly. Mobile technology has made such sound level measurements more feasible for even inexperienced users. Here, we assessed the accuracy of sound level measurements made using five mobile phone applications or "apps" on an Apple iPhone 4S, one of the most widely used mobile phones. Accuracy was assessed by comparing application-based measurements to measurements made using a calibrated SLM. Whereas most apps erred by reporting higher sound levels, one application measured levels within 5 dB of a calibrated SLM across all frequencies tested. PMID:25209033

  5. Sound level measurements using smartphone "apps": Useful or inaccurate?

    Directory of Open Access Journals (Sweden)

    Daniel R Nast

    2014-01-01

    Full Text Available Many recreational activities are accompanied by loud concurrent sounds and decisions regarding the hearing hazards associated with these activities depend on accurate sound measurements. Sound level meters (SLMs are designed for this purpose, but these are technical instruments that are not typically available in recreational settings and require training to use properly. Mobile technology has made such sound level measurements more feasible for even inexperienced users. Here, we assessed the accuracy of sound level measurements made using five mobile phone applications or "apps" on an Apple iPhone 4S, one of the most widely used mobile phones. Accuracy was assessed by comparing application-based measurements to measurements made using a calibrated SLM. Whereas most apps erred by reporting higher sound levels, one application measured levels within 5 dB of a calibrated SLM across all frequencies tested.

  6. Opportunities and threats for the launch of a smartphone app

    OpenAIRE

    Lopes, Eduardo Manuel Rosas Nobre Quinteiro

    2015-01-01

    Field lab: Entrepreneurial and innovative ventures The following work project illustrates the opportunities and threats of the industry for the launch of a smartphone app. In the first part, the technological and economic contextual drivers are analyzed in-depth through the study of key variables for the proliferation of the industry. In the second part, the characteristics of the market are exposed through a market assessment including an analysis of the industry rivalry and i...

  7. Discovering language variation in WhatsApp text interactions

    OpenAIRE

    Pérez-Sabater, Carmen

    2015-01-01

    This paper reports the process and outcomes of an instructional project to familiarise postgraduate students with research. The study presents Mobile-Var, a project which complies with the philosophy of the Bologna Declaration regarding students acquisition of research competences. By studying language variations in WhatsApp text interactions, participantswere encouraged to develop innovative ideas to make a tangible contribution to the field of language and Computer-mediated Communicatio...

  8. THE POTENTIAL OF BIOCHEMISTRY EDUCATION APPS IN THE FORMATIVE ASSESSMENT

    Directory of Open Access Journals (Sweden)

    M. L. Oliveira

    2015-08-01

    Full Text Available Introduction and objectives: Apps can be designed to provide usage data, and most of them do. These data are usually used to map users interests and to deliver more effective ads that are more likely to result in clicks, and sales. We have applied some of these metrics to understand how can it be used to map students’ behavior and to promote a formative assessment using educational software. The purpose of a formative assessment is to monitor student learning to provide ongoing feedback that can be used by instructors and students to improve the teaching and learning process. Thus, this modality aims to help both students and instructors to identify strengths and weaknesses that need to be developed. This study aimed to describe the potential of educational apps in the formative assessment process. Material and Methods: We have implemented assessment tools embedded in three apps (ARMET, The Cell and 3D Class used to teach: 1 Metabolic Pathways; 2 Scale of the cellular structures, and 3 Concepts from techniques used in a Biochemistry Lab course. The implemented tools allow to verify on what issues there were recurring mistakes, the total number of mistakes presented, which questions they most achieved, how long they took to perform the activity and other relevant information. Results and conclusion: Educational apps can provide transparent and coherent evaluation metrics to enable instructors to systematize more consistent criteria and indicators, reducing the subjectivity of the formative assessment process and the time spent for preparation, tabulation and analysis of assessment data. This approach allows instructors to understand better where students struggle, giving to them a more effective feedback. It also helps instructor to plan interventions to help students to perform better and to achieve the learning objectives.

  9. Practical Steps to Android App Development for Graphic Designers

    OpenAIRE

    Antikainen, Vesa

    2014-01-01

    The purpose of this thesis is to give graphic designers new to Android a clear view of what goes into developing an app. First all the basics of the Android OS are introduced with building blocks and concepts needed to get started. After introducing the fundamental elements, the thesis provides some recommendations on what programs could be used and how the overall workflow should go. In the final part previously mentioned building blocks and workflow patterns are put to use in the exampl...

  10. Evaluation of a Smartphone App for Forest Sample Plot Measurements

    Directory of Open Access Journals (Sweden)

    Mikko Vastaranta

    2015-04-01

    Full Text Available We evaluated a smartphone app (TRESTIMATM for forest sample plot measurements. The app interprets imagery collected from the sample plots using the camera in the smartphone and then estimates forest inventory attributes, including species-specific basal areas (G as well as the diameter (DgM and height (HgM of basal area median trees. The estimates from the smartphone app were compared to forest inventory attributes derived from tree-wise measurements using calipers and a Vertex height measurement device. The data consist of 2169 measured trees from 25 sample plots (32 m × 32 m, dominated by Scots pine and Norway spruce from southern Finland. The root-mean-square errors (RMSEs in the basal area varied from 19.7% to 29.3% and the biases from 11.4% to 18.4% depending on the number of images per sample plot and image shooting location. DgM measurement bias varied from −1.4% to 3.1% and RMSE from 5.2% to 11.6% depending on the tree species. Respectively, HgM bias varied from 5.0% to 8.3% and RMSE 10.0% to 13.6%. In general, four images captured toward the center of the plot provided more accurate results than four images captured away from the plot center. Increasing the number of captured images per plot to the analyses yielded only marginal improvement to the results.

  11. Development and Exploration of Web App Based on HTML5%基于 HTML5的 Web App 的开发与探索

    Institute of Scientific and Technical Information of China (English)

    章斓

    2015-01-01

    对于移动互联网行业来说,HTML5的出现带来了具有强大的跨平台兼容性的 Web APP———一种页面可直接适配手机屏幕、在浏览器上轻量运行、具有强大的表现能力、可实时更新且体验类似于 N-ative App 的网页应用。首先介绍了 Web App 的主要特点。在此基础上,阐述了基于 HTML5的 Web App 的实现。最后,分析了 Web APP 发展面临的机遇与挑战。%For the mobile Internet industry,the appearance of HTML5 brings about the powerful Web App with cross -platform compat-ibility.It is a page which could directly fit the phone screen,be operated conveniently on browsers,retain strong performance capaci-ty,provide real -time updates and offer user experience similar to Native App.This paper firstly introduces main features of Web App,expounds the realization of Web App based on HTML5 and analyzes opportunities and challenges for its development.

  12. Mobile apps for pediatric obesity prevention and treatment, healthy eating, and physical activity promotion: just fun and games?

    OpenAIRE

    Schoffman, Danielle E.; Turner-McGrievy, Gabrielle; Jones, Sonya J.; Wilcox, Sara

    2013-01-01

    Mobile applications (apps) offer a novel way to engage children in behavior change, but little is known about content of commercially available apps for this population. We analyzed the content of apps for iPhone/iPad for pediatric weight loss, healthy eating (HE), and physical activity (PA). Fifty-seven apps were downloaded and tested by two independent raters. Apps were coded for: inclusion of the Expert Committee for Pediatric Obesity Prevention's (ECPOP) eight recommended strategies (e.g....

  13. The use of mobile apps to improve nutrition outcomes: A systematic literature review.

    Science.gov (United States)

    DiFilippo, Kristen N; Huang, Wen-Hao; Andrade, Juan E; Chapman-Novakofski, Karen M

    2015-07-01

    We conducted a systematic review to determine if the use of nutrition apps resulted in improved outcomes, including knowledge and behavior, among healthy adults. Using app(s), cellular phone, iPads, mobile phone, mobile telephone, smart phone, mobile and mHealth as search terms with diet, food and nutrition as qualifiers we searched PubMed, CINAHL (January 2008-October 2013) and Web of Science (January 2008-January 2014). Inclusion criteria were peer-reviewed randomized controlled trials, non-controlled trials, and cohort studies published in English that used apps to increase nutrition knowledge or improve behavior related to nutrition. Studies that were descriptive, did not include apps, focused on app development, app satisfaction app feasibility, text messaging, or digital photography were excluded. We evaluated article quality using the Academy of Nutrition and Dietetics Evidence Analysis Manual. Data was extracted for knowledge, behavior and weight change. Our initial search identified 12,010 titles from PubMed, 260 from CINAHL and 4762 from Web of Science; of these, only four articles met all search criteria. Positive quality ratings were given to three articles; only one reported knowledge outcomes (non-significant). All four articles evaluated weight loss and suggested an advantage to using nutrition apps. Behavioral changes in reviewed studies included increased adherence to diet monitoring (p behavior theory within the app and improved study design. PMID:25680388

  14. Mobile Health Apps to Facilitate Self-Care: A Qualitative Study of User Experiences.

    Directory of Open Access Journals (Sweden)

    Kevin Anderson

    Full Text Available Consumers are living longer, creating more pressure on the health system and increasing their requirement for self-care of chronic conditions. Despite rapidly-increasing numbers of mobile health applications ('apps' for consumers' self-care, there is a paucity of research into consumer engagement with electronic self-monitoring. This paper presents a qualitative exploration of how health consumers use apps for health monitoring, their perceived benefits from use of health apps, and suggestions for improvement of health apps.'Health app' was defined as any commercially-available health or fitness app with capacity for self-monitoring. English-speaking consumers aged 18 years and older using any health app for self-monitoring were recruited for interview from the metropolitan area of Perth, Australia. The semi-structured interview guide comprised questions based on the Technology Acceptance Model, Health Information Technology Acceptance Model, and the Mobile Application Rating Scale, and is the only study to do so. These models also facilitated deductive thematic analysis of interview transcripts. Implicit and explicit responses not aligned to these models were analyzed inductively.Twenty-two consumers (15 female, seven male participated, 13 of whom were aged 26-35 years. Eighteen participants reported on apps used on iPhones. Apps were used to monitor diabetes, asthma, depression, celiac disease, blood pressure, chronic migraine, pain management, menstrual cycle irregularity, and fitness. Most were used approximately weekly for several minutes per session, and prior to meeting initial milestones, with significantly decreased usage thereafter. Deductive and inductive thematic analysis reduced the data to four dominant themes: engagement in use of the app; technical functionality of the app; ease of use and design features; and management of consumers' data.The semi-structured interviews provided insight into usage, benefits and challenges of

  15. 右美托咪定对不同年龄患者顺行性遗忘作用的影响%Effects of dexmedetomidine on the anterograde amnesia in patients with different ages

    Institute of Scientific and Technical Information of China (English)

    胡志超; 孔莉; 许鹏程; 李颖; 董晓辉

    2015-01-01

    Objective To study the effects of dexmedetomidine on the anterograde amnesia in patients with different ages.Methods One hundred and twenty ASAⅠ~Ⅱpatients, age from 18 years to 84 years, 73 cases of male and 47 cases of female , who were dministered spinal-epidural anesthesia combined with dexmedetomidine and performed operation on hypogastrium ( except for caesarean section ) .All patients were randomly divided into four groups:group A, group B, group C and group D.Dexmedetomidine(1μg/kg) was infused intravenously for 10 min and the maintenance dose was 0.2 μg・ kg-1・ h-1 .The anterograde amnesia degree of dexmedetomidine was as-sessed 24 h after the operation .Results There was no significant difference in the anterograde amnesia of dexmedeto -midine between group A and group B ( P>0.05 ) , while there were significant differences in group C and group D compared with both group A and group B ( P<0.05 ) .Conclusion Anterograde amnesia occurs after using dexme-detomidine in elderly patients and with aging , the anterograde amnesia becomes more severe .%目的:观察右美托咪定对不同年龄患者顺行性遗忘作用的影响。方法选择美国麻醉医师学会( ASA)Ⅰ~Ⅱ级、年龄18~84岁,在腰硬联合麻醉下复合右美托咪定行下腹部(剖宫产术除外)手术患者120例,其中男73例,女47例。根据患者年龄的不同分为四组:A组(23±4)岁, B组(36±3)岁, C组(65±3)岁,D组(75±5)岁。所有患者均给予右美托咪定负荷量1μg/kg,泵入10 min之后以0.2μg・ kg-1・ h-1剂量维持。术后24 h回访患者并评定右美托咪定的顺行性遗忘作用。结果 A组和B组右美托咪定顺行性遗忘作用无明显不同(P>0.05),而C组与D组较前两组右美托咪定顺行性遗忘作用比较明显(P<0.05),并随年龄的增大明显增加( P<0.05)。结论右美托咪定具有一定的顺行性遗忘作用,且对老年患者更为明显。

  16. 78 FR 18416 - Commercial Space Transportation Advisory Committee; Open Meeting

    Science.gov (United States)

    2013-03-26

    ... Federal Aviation Administration Commercial Space Transportation Advisory Committee; Open Meeting AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory.... 92-463, 5 U.S.C. App. 2), notice is hereby given of a meeting of the Commercial Space...

  17. 78 FR 53496 - Commercial Space Transportation Advisory Committee; Open Meeting

    Science.gov (United States)

    2013-08-29

    ... Federal Aviation Administration Commercial Space Transportation Advisory Committee; Open Meeting AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory.... 92-463, 5 U.S.C. App. 2), notice is hereby given of a meeting of the Commercial Space...

  18. 基于移动用户体验的 APP 设计%The Exploration of APP Design based on Mobile User Experience

    Institute of Scientific and Technical Information of China (English)

    陆远蓉

    2014-01-01

    未来的互联网将是以移动网络链接为主的移动互联网,APP 作为移动设备功能的扩展,受到越来越多用户的关注,移动互联网有 APP 化的趋势。从日常产品的用户体验案例分析 APP 设计中用户体验的必要性,说明用户体验、尤其是移动用户体验成为 APP 的竞争软实力,成为衡量产品成功与否的一项指标,也是助力在激烈 APP 市场竞争、趋同的企业间技术突围而出的要素之一。%The future Internet would be the mobile one centerd round mobile network link.There is growing concern about APP,which is taken as the extension to mobile device capabilities,and simultaneously mobile network shows the tendency of APP state.The paper gets help from user experience case of everyday products to analyze the necessity of user experience in the process of APP design,and proves user experience ,especially mobile user experience,has become the competition soft power of APP.Moreover,the mobile user experience is an indicator to judge the success or not of a product,and is al-so one of the elements to gain its predominance in the fierce market competition of APP,as well as under the background of technological convergence between enterprises.

  19. Using the FAIMS Mobile App for field data recording

    Science.gov (United States)

    Ballsun-Stanton, Brian; Klump, Jens; Ross, Shawn

    2016-04-01

    Multiple people creating data in the field poses a hard technical problem: our ``web 2.0'' environment presumes constant connectivity, data ``authority'' held by centralised servers, and sees mobile devices as tools for presentation rather than origination. A particular design challenge is the remoteness of the sampling locations, hundreds of kilometres away from network access. The alternative, however, is hand collection with a lengthy, error prone, and expensive digitisation process. This poster will present a field-tested open-source solution to field data recording. This solution, originally created by a community of archaeologists, needed to accommodate diverse recording methodologies. The community could not agree on standard vocabularies, workflows, attributes, or methodologies, but most agreed that at app to ``record data in the field'' was desirable. As a result, the app is generalised for field data collection; not only can it record a range of data types, but it is deeply customisable. The NeCTAR / ARC funded FAIMS Project, therefore, created an app which allows for arbitrary data collection in the field. In order to accomplish this ambitious goal, FAIMS relied heavily on OSS projects including: spatialite and gdal (for GIS support), sqlite (for a lightweight key-attribute-value datastore), Javarosa and Beanshell (for UI and scripting), Ruby, and Linux. Only by standing on the shoulders of giants, FAIMS was able to make a flexible and highly generalisable field data collection system that CSIRO geoscientists were able to customise to suit most of their completely unanticipated needs. While single-task apps (i.e. those commissioned by structural geologists to take strikes and dips) will excel in their domains, other geoscientists (palaeoecologists, palaeontologists, anyone taking samples) likely cannot afford to commission domain- and methodology-specific recording tools for their custom recording needs. FAIMS shows the utility of OSS software

  20. Route Optimization via RSSI APPs in Indoor Proxy Mobile IPv6 Test-bed

    Directory of Open Access Journals (Sweden)

    Nur Haliza Abdul Wahab

    2014-08-01

    Full Text Available Traditionally IP mobility support mechanisms, Mobile IPv4 or Mobile IPv6 are based on the host-based solution to keep on going sessions despite the movement. The current trend is towards networks-based solutions where mobility support is based on network operation. Proxy Mobile IPv6 (PMIPv6 has been developed by the Internet Engineering Task Force (IETF as a network-based mobility management protocol. The development is aimed to guarantee and support mobility for IP devices or called as Mobile Node (MN without the MN involving in any IP layer mobility related to signaling as stated in RFC5213. PMIPv6 in RFC5213 address the needed to enable Localized Routing (LR but it not specify a complete procedure to establish Route Optimization (RO. Data packets belong to MN need to travel to Local Mobility Anchor (LMA via bidirectional tunnel between Mobile Access Gateway (MAG and LMA. This result to long end to end delay. This un-optimized route result in increasing signaling data delay, huge handover latency, large transport cost and many more. Therefore, it important to optimized the data path so that the data destined to MN will be traverse using the shorter path or directly change traffic tunnel between MAG. As for this, the aims of this study are to reduce the handover latency and optimized data route by the illustration of development the PMIPv6 test-bed with implementation of RO via RSSI APPs. Several experiment will be discuss to see the performance of RO algorithm via RSSI APPs with non-optimized RO.

  1. What Makes Users Buy Paid Smartphone Applications? Examining App, Personal, and Social Influences

    Directory of Open Access Journals (Sweden)

    LINA WU

    2015-04-01

    Full Text Available This study proposes an integrated model of users’ intention to purchase paid smartphone applications. Focusing on individual-level perceptions of paid smartphone apps, it investigates the impacts of paid apps’ characteristics (perceived usefulness and perceived price, as well as their users’ personal (personal motivation and self-efficacy and social (mass influence and peer influence characteristics on users’ attitude toward paid apps, which in turn influence users’ intention to purchase them. The proposed research model was evaluated using data collected from 231 respondents through the structural equation modeling technique. The results showed that perceived usefulness, self-efficacy, and peer influence are critical determinants of users’ attitude toward paid apps, which can lead to users’ intention to purchase paid apps. By highlighting the purchasing process of smartphone paid apps, it may provide guidance to app vendors to launch their new products or services in a successful manner.

  2. A multiplexed immunoassay for detection of antibodies to Actinobacillus pleuropneumoniae (App) in pigs

    DEFF Research Database (Denmark)

    Berger, Sanne Schou; Boas, Ulrik; Andresen, Lars Ole;

    2014-01-01

    The bacterium Actinobacillus pleuropneumoniae (App) is the causative agent of porcine pleuropneumoniae, a contagious and severe respiratory disease in pigs. Based on capsular antigens, 15 App serovars have been described, and the prevalence and morbidity of these serovars vary with geographic...... regions (1). In Denmark, the most important serovars are considered to be App 1, 2, 5, 6, 7, 10 and 12. As part of the Danish surveillance program for App, the Danish Veterinary Institute uses ELISAs and complement fixation tests (CFT) to test for porcine anti-App antibodies (2-7). In an effort to improve...... our diagnostic tools, we are currently developing a novel indirect fluorescent microsphere immunoassay that can facilitate simultaneous detection of antibodies towards multiple App serovars within a single serum sample volume. The multiplex immunoassay is based on Luminex technology (8) and has...

  3. An Empirical Assessment of a Technology Acceptance Model for Apps in Medical Education.

    Science.gov (United States)

    Briz-Ponce, Laura; García-Peñalvo, Francisco José

    2015-11-01

    The evolution and the growth of mobile applications ("apps") in our society is a reality. This general trend is still upward and the app use has also penetrated the medical education community. However, there is a lot of unawareness of the students' and professionals' point of view about introducing "apps" within Medical School curriculum. The aim of this research is to design, implement and verify that the Technology Acceptance Model (TAM) can be employed to measure and explain the acceptance of mobile technology and "apps" within Medical Education. The methodology was based on a survey distributed to students and medical professionals from University of Salamanca. This model explains 46.7% of behavioral intention to use mobile devise or "apps" for learning and will help us to justify and understand the current situation of introducing "apps" into the Medical School curriculum.

  4. Opposing effects of APP/PS1 and TrkB.T1 genotypes on midbrain dopamine neurons and stimulated dopamine release in vivo.

    Science.gov (United States)

    Kärkkäinen, E; Yavich, L; Miettinen, P O; Tanila, H

    2015-10-01

    Brain derived neurotrophic factor (BDNF) signaling disturbances in Alzheimer׳s disease (AD) have been demonstrated. BDNF levels fall in AD, but the ratio between truncated and full-length BDNF receptors TrkB.T1 and TrkB.TK, respectively, increases in brains of AD patients and APPswe/PS1dE9 (APP/PS1) AD model mice. Dopaminergic (DAergic) system disturbances in AD and detrimental effects of BDNF signaling deficits on DAergic system functions have also been indicated. Against this, we investigated changes in nigrostriatal dopamine (DA) system in mice carrying APP/PS1 and/or TrkB.T1 transgenes, the latter line modeling the TrkB.T1/TK ratio change in AD. Employing in vivo voltammetry, we found normal short-term DA release in caudate-putamen of mice carrying APP/PS1 or TrkB.T1 transgenes but impaired capacity to recruit more DA upon prolonged stimulation. However, mice carrying both transgenes did not differ from wild-type controls. Immunohistochemistry revealed normal density of tyrosine hydroxylase positive axon terminals in caudate-putamen in all genotypes and intact presynaptic machinery for DA release and reuptake, as shown by unchanged levels of SNAP-25, α-synuclein and DA transporter. However, we observed increased DAergic neurons in substantia nigra of TrkB.T1 mice resulting in decreased tyrosine hydroxylase per neuron in TrkB.T1 mice. The finding of unchanged nigral DAergic neurons in APP/PS1 mice largely confirms earlier reports, but the unexpected increase in midbrain DA neurons in TrkB.T1 mice is a novel finding. We suggest that both APP/PS1 and TrkB.T1 genotypes disrupt DAergic signaling, but via separate mechanisms.

  5. The Most Popular Smartphone Apps for Weight Loss: A Quality Assessment

    OpenAIRE

    Chen, Juliana; Cade, Janet E; Allman-Farinelli, Margaret

    2015-01-01

    Background Advancements in mobile phone technology have led to the development of smartphones with the capability to run apps. The availability of a plethora of health- and fitness-related smartphone apps has the potential, both on a clinical and public health level, to facilitate healthy behavior change and weight management. However, current top-rated apps in this area have not been extensively evaluated in terms of scientific quality and behavioral theory evidence base. Objective The purpo...

  6. Modulation of human neural stem cell differentiation in Alzheimer (APP23) transgenic mice by phenserine.

    Science.gov (United States)

    Marutle, Amelia; Ohmitsu, Masao; Nilbratt, Mats; Greig, Nigel H; Nordberg, Agneta; Sugaya, Kiminobu

    2007-07-24

    In a previous study, we found that human neural stem cells (HNSCs) exposed to high concentrations of secreted amyloid-precursor protein (sAPP) in vitro differentiated into mainly astrocytes, suggesting that pathological alterations in APP processing during neurodegenerative conditions such as Alzheimer's disease (AD) may prevent neuronal differentiation of HNSCs. Thus, successful neuroplacement therapy for AD may require regulating APP expression to favorable levels to enhance neuronal differentiation of HNSCs. Phenserine, a recently developed cholinesterase inhibitor (ChEI), has been reported to reduce APP levels in vitro and in vivo. In this study, we found reductions of APP and glial fibrillary acidic protein (GFAP) levels in the hippocampus of APP23 mice after 14 days treatment with (+)-phenserine (25 mg/kg) lacking ChEI activity. No significant change in APP gene expression was detected, suggesting that (+)-phenserine decreases APP levels and reactive astrocytes by posttranscription regulation. HNSCs transplanted into (+)-phenserine-treated APP23 mice followed by an additional 7 days of treatment with (+)-phenserine migrated and differentiated into neurons in the hippocampus and cortex after 6 weeks. Moreover, (+)-phenserine significantly increased neuronal differentiation of implanted HNSCs in hippocampal and cortical regions of APP23 mice and in the CA1 region of control mice. These results indicate that (+)-phenserine reduces APP protein in vivo and increases neuronal differentiation of HNSCs. Combination use of HNSC transplantation and treatment with drugs such as (+)-phenserine that modulate APP levels in the brain may be a useful tool for understanding mechanisms regulating stem cell migration and differentiation during neurodegenerative conditions in AD.

  7. Security Recommendations for mHealth Apps: Elaboration of a Developer's Guide.

    Science.gov (United States)

    Morera, Enrique Pérez; de la Torre Díez, Isabel; Garcia-Zapirain, Begoña; López-Coronado, Miguel; Arambarri, Jon

    2016-06-01

    Being the third fastest-growing app category behind games and utilities, mHealth apps are changing the healthcare model, as medicine today involves the data they compile and analyse, information known as Big Data. However, the majority of apps are lacking in security when gathering and dealing with the information, which becomes a serious problem. This article presents a guide regarding security solution, intended to be of great use for developers of mHealth apps. In August 2015 current mobile health apps were sought out in virtual stores such as Android Google Play, Apple iTunes App Store etc., in order to classify them in terms of usefulness. After this search, the most widespread weaknesses in the field of security in the development of these mobile apps were examined, based on sources such as the "OWASP Mobile Security Project, the initiative recently launched by the Office of Civil Rights (OCR), and other articles of scientific interest. An informative, elemental guide has been created for the development of mHealth apps. It includes information about elements of security and its implementation on different levels for all types of mobile health apps based on the data that each app manipulates, the associated calculated risk as a result of the likelihood of occurrence and the threat level resulting from its vulnerabilities - high level (apps for monitoring, diagnosis, treatment and care) from 6 ≤ 9, medium level (calculator, localizer and alarm) from 3 ≤ 6 and low level (informative and educational apps) from 0 ≤ 3. The guide aims to guarantee and facilitate security measures in the development of mobile health applications by programmers unconnected to the ITC and professional health areas. PMID:27147515

  8. Smartphone Apps for Cardiopulmonary Resuscitation Training and Real Incident Support: A Mixed-Methods Evaluation Study

    OpenAIRE

    Kalz, Marco; Lenssen, Niklas; Felzen, Marco; Rossaint, Rolf; Tabuenca, Bernardo; Specht, Marcus; Skorning, Max

    2014-01-01

    Background: No systematic evaluation of smartphone/mobile apps for resuscitation training and real incident support is available to date. To provide medical, usability, and additional quality criteria for the development of apps, we conducted a mixed-methods sequential evaluation combining the perspective of medical experts and end-users. Objective: The study aims to assess the quality of current mobile apps for cardiopulmonary resuscitation (CPR) training and real incident support from exper...

  9. Exploring the application of a conceptual framework in a social MALL app

    OpenAIRE

    Read, Timothy; Bárcena, Elena; Kukulska-Hulme, Agnes

    2016-01-01

    This article presents a prototype social Mobile Assisted Language Learning (henceforth, MALL) app based on Kukulska-Hulme’s (2012) conceptual framework. This research allows the exploration of time, place and activity type as key factors in the design of MALL apps, and is the first step toward a systematic analysis of such a framework in this type of app in the future. Firstly, the selected conceptual framework is discussed, emphasizing the adequacy of its development (or even adaptation) for...

  10. In Front of And Behind The Second Screen: Viewer and Producer Perspectives on a Companion App

    OpenAIRE

    Geerts, David; Leenheer, Rinze; De Grooff, Dirk

    2014-01-01

    The growing success of tablets and smartphones has shifted the focus of the interactive TV industry to the introduction of second screen applications. One example is second screen companion apps that offer extra information about a television program, often synchronized with what happens on screen. In this paper, we investigate a second screen companion app, from the perspective of the viewers and producers of such apps. Based on observations and interviews with viewers and producers, and act...

  11. What Explains Usage of Mobile Physician-Rating Apps? Results From a Web-Based Questionnaire

    OpenAIRE

    Bidmon, Sonja; Terlutter, Ralf; Röttl, Johanna

    2014-01-01

    Background Consumers are increasingly accessing health-related information via mobile devices. Recently, several apps to rate and locate physicians have been released in the United States and Germany. However, knowledge about what kinds of variables explain usage of mobile physician-rating apps is still lacking. Objective This study analyzes factors influencing the adoption of and willingness to pay for mobile physician-rating apps. A structural equation model was developed based on the Techn...

  12. Instagram and WhatsApp in Health and Healthcare: An Overview

    Directory of Open Access Journals (Sweden)

    Maged N. Kamel Boulos

    2016-07-01

    Full Text Available Instagram and WhatsApp are two social media and networking services introduced in 2010. They are currently subsidiaries of Facebook, Inc., California, USA. Using evidence from the published literature and case reports indexed in PubMed and other sources, we present an overview of the various applications of Instagram and WhatsApp in health and healthcare. We also briefly describe the main issues surrounding the uses of these two apps in health and medicine.

  13. A Business Model Canvas for iDecide - How to Design a New Decision Making App?

    OpenAIRE

    Luft, Thomas; Lamé, Guillaume; Ponn, Joseph; Stal-Le Cardinal, Julie; Wartzack, Sandro

    2016-01-01

    International audience As products become increasingly complex, product developers have to make decisions effectively and efficiently. Therefore, the long term goal of the SIG DM is to develop an iDecide App. This app should support developers in complex decision making situations during the development process. The aim of this paper is to describe possible business models for an iDecide App with the Business Model Canvas. Some business models and one industrial case study for an iDecide A...

  14. Local content production and the political economy of the app industries

    OpenAIRE

    Wagner, Sarah; Fernández Ardèvol, Mireia

    2015-01-01

    Mobile broadband is playing an increasingly important role in the developing world. However, mobile platform providers and app publishers are dominated by multinational companies headquartered in the West. Where international agendas commit to promote local content production and a culturally diverse information society, there is minimal research on the orientation of commercial app production in developing regions. This article examines the targets and activities of mobile app develope...

  15. The Bluetooth Based LED Control For Arduino Test Platform By Using Mobile APP

    OpenAIRE

    Yi-Jen Mon

    2015-01-01

    Abstract The Bluetooth is a commonly known convenient and famous communication protocol. In this paper it is used to control LED mounted on Arduino test platform by using the APP of mobile phone. At first the control program is completed by Arduino development software environment then the Android APP is installed in mobile phone. Finally by using the Bluetooth of mobile phone the test platform will be connected. The LED can be controlled by APP of mobile phone. The experiment results are dem...

  16. Review and Evaluation of Mindfulness-Based iPhone Apps

    OpenAIRE

    Mani, Madhavan; David J. Kavanagh; Hides, Leanne; Stoyanov, Stoyan R

    2015-01-01

    Background There is growing evidence for the positive impact of mindfulness on wellbeing. Mindfulness-based mobile apps may have potential as an alternative delivery medium for training. While there are hundreds of such apps, there is little information on their quality. Objective This study aimed to conduct a systematic review of mindfulness-based iPhone mobile apps and to evaluate their quality using a recently-developed expert rating scale, the Mobile Application Rating Scale (MARS). It al...

  17. Security Recommendations for mHealth Apps: Elaboration of a Developer's Guide.

    Science.gov (United States)

    Morera, Enrique Pérez; de la Torre Díez, Isabel; Garcia-Zapirain, Begoña; López-Coronado, Miguel; Arambarri, Jon

    2016-06-01

    Being the third fastest-growing app category behind games and utilities, mHealth apps are changing the healthcare model, as medicine today involves the data they compile and analyse, information known as Big Data. However, the majority of apps are lacking in security when gathering and dealing with the information, which becomes a serious problem. This article presents a guide regarding security solution, intended to be of great use for developers of mHealth apps. In August 2015 current mobile health apps were sought out in virtual stores such as Android Google Play, Apple iTunes App Store etc., in order to classify them in terms of usefulness. After this search, the most widespread weaknesses in the field of security in the development of these mobile apps were examined, based on sources such as the "OWASP Mobile Security Project, the initiative recently launched by the Office of Civil Rights (OCR), and other articles of scientific interest. An informative, elemental guide has been created for the development of mHealth apps. It includes information about elements of security and its implementation on different levels for all types of mobile health apps based on the data that each app manipulates, the associated calculated risk as a result of the likelihood of occurrence and the threat level resulting from its vulnerabilities - high level (apps for monitoring, diagnosis, treatment and care) from 6 ≤ 9, medium level (calculator, localizer and alarm) from 3 ≤ 6 and low level (informative and educational apps) from 0 ≤ 3. The guide aims to guarantee and facilitate security measures in the development of mobile health applications by programmers unconnected to the ITC and professional health areas.

  18. What Overweight Women Want From a Weight Loss App: A Qualitative Study on Arabic Women

    OpenAIRE

    Alnasser, Aroub Abdulaziz; Alkhalifa, Abdulrahman Saleh; Sathiaseelan, Arjuna; Marais, Debbi

    2015-01-01

    Background Overweight and obesity are international public health issues. With mobile and app use growing globally, the development of weight loss apps are increasing along with evidence that interventions using technology have been effective in the treatment of obesity. Although studies have been conducted regarding what content health professionals would recommend within weight loss apps, there are limited studies that explore users’ viewpoints. There is specifically a paucity of research t...

  19. Computational Thinking Oriented App Inventor Course Construction and Practice%面向计算思维的App Inventor课程建设与实践

    Institute of Scientific and Technical Information of China (English)

    吴明晖

    2015-01-01

    Aiming to promote the computational thinking ability cultivation , the course “App Inventor for Mobile Apps Developing” was built for the students without programming skills .App Inventor is a programming tool for Android apps with graphical building blocks , which is suitable for beginners .Based on the characters of App Inventor , the course has designed a series of interesting cases to induce related knowledge and skills . The teaching methods including case inducing , project driven , and competition integrated , which inspired students'interest and creative , and enhanced the cultivating of computational thinking .%针对大学计算思维能力的培养,以Android应用的图形化积木式编程软件App Inventor为载体,面向不具备编程基础的大一学生和非计算机专业大学生,建设了App Inventor移动应用开发课程。设计了系列趣味教学案例引导相关方法和技能,并融入计算思维培养。通过案例引导、项目驱动、学赛结合的教学方式,激发了学生兴趣和创意,增强了计算思维的培养。

  20. Designing for Windows 8 fundamentals of great design in Windows Store apps

    CERN Document Server

    Schooley, Brent

    2013-01-01

    Designing for Windows 8 is a fast-paced, 150-page primer on the key design concepts you need to create successful Windows 8 apps. This book will help you design a user interface that is both delightful and effective, feels 'right' to your users, and encapsulates a great Windows 8 experience. In this book, you will: Meet the building blocks of solid Windows 8 UI design in a well-designed sample app. Learn how to incorporate key design elements into your apps, such as the app bar, charms and subtle animations from the animation library. Find out how to deliver the core experience that your users

  1. Pro Android Web Apps Develop for Android Using HTML5, CSS3 and JavaScript

    CERN Document Server

    Oehlman, Damon

    2011-01-01

    Developing applications for Android and other mobile devices using web technologies is now well within reach. When the capabilities of HTML5 are combined with CSS3 and JavaScript, web application developers have an opportunity to develop compelling mobile applications using familiar tools. Not only is it possible to build mobile web apps that feel as good as native apps, but to also write an application once and have it run a variety of different devices. While the HTML5 specification is still evolving, there is a lot that can be used right now to build mobile web apps. Mobile web apps are now

  2. Interaction of Stathmin-Like 2 Protein with the APP Intracellular Domain

    Institute of Scientific and Technical Information of China (English)

    LI Zhidong; WANG Weiwei; ZHOU Fangfang; GAO Xia; PENG Gaonong; XU Huaxi; CHEN Ye-Guang

    2005-01-01

    Amyloid precursor protein (APP) plays a critical role in the formation of Alzheimer's disease (AD). The intracellular domain APP (AID) was suggested to cause neurotoxicity in the nucleus. To investigate the functions AID, yeast two-hybrid screening was performed to identify the proteins which interact with AID. The human brain cDNA library was screened using pGBKT7-AID as a bait, and several positive clones were identified. One of them encodes a part of the human stathmin-like 2 protein (STMN2). The interaction between STMN2 and APP implies that STMN2 may have an important function in APP-mediated AD formation.

  3. App Law Within:Rights and Regulation in the Smartphone Age

    OpenAIRE

    Mac Sithigh, Daithi

    2012-01-01

    This paper assesses the regulation of smartphone 'app stores.' At the outset, the adoption of smartphones and apps is noted, alongside the ways in which scholars and journalists have used these markets as the basis for the discussion of legal and economic issues. The importance (commercially and as a study in governance and control) of the iOS App Store (Apple) is highlighted. Part 2 deals with the relationship between Apple and app developers; three themes of Apple’s Guidelines are identifie...

  4. App Law Within:Rights and Regulation in the Smartphone Age

    OpenAIRE

    Mac Sithigh, Daithi

    2013-01-01

    This article assesses the regulation of smartphone ‘app stores’. At the outset, the significance of smartphones and apps to the debate on Internet regulation is considered, and places in the context of the adoption of smartphones and apps. The importance (commercially and as a study in governance and control) of the iOS App Store (Apple) is highlighted, as is the need to explore forms of regulation that are not linked with a violation of competition law. Section ‘Developer-focused issues’ dea...

  5. Developing an App for College Women in Abusive Same-Sex Relationships and Their Friends.

    Science.gov (United States)

    Bloom, Tina; Gielen, Andrea; Glass, Nancy

    2016-06-01

    Young women experiencing dating violence in same-sex relationships face significant barriers to help for safety planning. Therefore, our team developed a tailored smartphone safety decision aid app for dating violence survivors and their peers. College women survivors of same-sex dating violence, peers, and college staff reviewed the app, identifying users' barriers to information, resources, and services and key strategies for dissemination, inclusiveness, and safety for the app. Findings support the use of the app to assist college women experiencing same-sex dating violence and peers to connect with resources and develop tailored safety plans to reduce violence and increase their safety. PMID:26515797

  6. mHealth Quality: A Process to Seal the Qualified Mobile Health Apps.

    Science.gov (United States)

    Yasini, Mobin; Beranger, Jérôme; Desmarais, Pierre; Perez, Lucas; Marchand, Guillaume

    2016-01-01

    A large number of mobile health applications (apps) are currently available with a variety of functionalities. The user ratings in the app stores seem not to be reliable to determine the quality of the apps. The traditional methods of evaluation are not suitable for fast paced nature of mobile technology. In this study, we propose a collaborative multidimensional scale to assess the quality of mHealth apps. During our process, the app quality is assessed in various aspects including medical reliability, legal consistency, ethical consistency, usability aspects, personal data privacy and IT security. A hypothetico-deductive approach was used in various working groups to define the audit criteria based on the various use cases that an app could provide. These criteria were then implemented into a web based self-administered questionnaires and the generation of automatic reports were considered. This method is on the one hand specific to each app because it allows to assess each health app according to its offered functionalities. On the other hand, this method is automatic, transferable to all apps and adapted to the dynamic nature of mobile technology. PMID:27577372

  7. A critical exploration of the Brussels app economy and mobile city services scene

    OpenAIRE

    Walravens, Nils

    2014-01-01

    This paper combines quantitative and qualitative methods to take a first look at the app economy and mobile services landscape in the City and Region of Brussels, capital of Belgium and Europe. By scraping the iTunes App Store and Google Play market places we get a view on platform distribution, pricing, public vs. commercial, adoption, appreciation and popular categories of Brussels apps, as well as a view on the app economy in the city. This data is then complemented by qualitative expert i...

  8. Popular Mobile Phone Apps for Diet and Weight Loss: A Content Analysis

    Science.gov (United States)

    Roehrer, Erin

    2016-01-01

    Background A review of the literature has revealed that the rates of overweight and obesity have been increasing in Australia over the last two decades and that wellness mobile phone apps play a significant role in monitoring and managing individuals’ weight. Although mobile phone app markets (iTunes and Google Play) list thousands of mobile phone health apps, it is not always clear whether those apps are supported by credible sources. Likewise, despite the prevailing use of mobile phone apps to aid with weight management, the usability features of these apps are not well characterized. Objective The research explored how usability taxonomy could inform the popularity of downloaded, socially focused wellness mobile phone apps, in particular weight loss and diet apps. The aim of the study was to investigate the Australian mobile phone app stores (iTunes and Google Play) in order to examine the usability features of the most popular (ie, most downloaded) wellness apps. Methods The design of this study comprises 3 main stages: stage 1, identifying apps; stage 2, development of weight loss and diet evaluation framework; and stage 3, application of the evaluation framework. Each stage includes specific data collection, analysis tools, and techniques. Results The study has resulted in the development of a justified evaluation framework for weight loss and diet mobile phone apps. Applying the evaluation framework to the identified apps has shown that the most downloaded iTunes and Google Play apps are not necessarily the most usable or effective. In addition, the research found that search algorithms for iTunes and Google Play are biased toward apps’ titles and keywords that do not accurately define the real functionality of the app. Moreover, the study has also analyzed the apps’ user reviews, which served as justification for the developed evaluation framework. Conclusions The analysis has shown that ease of use, reminder, bar code scanning, motivation, usable for

  9. Substance Abuse and Mental Health Services Administration (SAMHSA) Behavioral Health Disaster Response App.

    Science.gov (United States)

    Seligman, Jamie; Felder, Stephanie S; Robinson, Maryann E

    2015-10-01

    The Substance Abuse and Mental Health Services Administration (SAMHSA) in the Department of Health and Human Services offers extensive disaster behavior health resources to assist disaster survivors in preparing for, responding to, and recovering from natural and manmade disasters. One of SAMHSA's most innovative resources is the SAMHSA Behavioral Health Disaster Response App (SAMHSA Disaster App). The SAMHSA Disaster App prepares behavioral health responders for any type of traumatic event by allowing them to access disaster-related materials and other key resources right on their phone, at the touch of a button. The SAMHSA Disaster App is available on iPhone, Android, and BlackBerry devices. PMID:26165522

  10. Co-Designing Mobile Apps to Assist in Clinical Nursing Education: A Study Protocol.

    Science.gov (United States)

    O'Connor, Siobhan; Andrews, Tom

    2016-01-01

    Mobile applications (apps) to train health professionals is gaining momentum as the benefits of mobile learning (mLearning) are becoming apparent in complex clinical environments. However, most educational apps are generic, off-the-shelf pieces of software that do not take into consideration the unique needs of nursing students. The proposed study will apply a user-centred design process to create a tailored mobile app for nursing students to learn and apply clinical skills in practice. The app will be piloted and evaluated to understand how nursing students use mobile technology in clinical settings to support their learning and educational needs. PMID:27332433

  11. MateriApps — a Portal Site of Materials Science Simulation

    Science.gov (United States)

    Konishi, Yusuke; Igarashi, Ryo; Kasamatsu, Shusuke; Kato, Takeo; Kawashima, Naoki; Kawatsu, Tsutomu; Kouta, Hikaru; Noda, Masashi; Sasaki, Shoichi; Terada, Yayoi; Todo, Synge; Tsuchida, Shigehiro; Yoshimi, Kazuyoshi; Yoshizawa, Kanako

    "MateriApps" is a portal website of computational materials science simulation that has a database containing over 100 application software including density functional theory calculation, quantum chemistry, molecular dynamics, etc. On the MateriApps website, researchers can find applications suitable for their own research in materials science by browsing the website or searching by keywords. We also provide forums and tutorial courses of applications. In order to avoid troublesome installation procedures and provide users an environment in which they can try out various applications easily, we develop and freely distribute "MateriApps LIVE!," a live Linux system, in which several applications introduced in MateriApps are pre-installed.

  12. Testing iOS apps with HadoopUnit rapid distributed GUI testing

    CERN Document Server

    Tilley, Scott

    2014-01-01

    Smartphone users have come to expect high-quality apps. This has increased the importance of software testing in mobile software development. Unfortunately, testing apps-particularly the GUI-can be very time-consuming. Exercising every user interface element and verifying transitions between different views of the app under test quickly becomes problematic. For example, execution of iOS GUI test suites using Apple's UI Automation framework can take an hour or more if the app's interface is complicated. The longer it takes to run a test, the less frequently the test can be run, which in turn re

  13. iPhone and iPad apps every user should own

    CERN Document Server

    Team, The Hyperink

    2012-01-01

    ABOUT THE BOOK You've probably already heard this said: there has never been a better time to download apps tailored to your "on-the-go" interests and goals than now. In fact, it's a reality we're all counting on; that extra support and access is so darn promising for individuals and businesses alike. And indeed, app downloads do continue to rise to express both our yearnings and the continued undiminished popularity of apps themselves. The Apple blog cites 32.2 million app downloads per day by Mac users, nearly three times more than music downloads on iTunes while AdMob offers up some comp

  14. Substance Abuse and Mental Health Services Administration (SAMHSA) Behavioral Health Disaster Response App.

    Science.gov (United States)

    Seligman, Jamie; Felder, Stephanie S; Robinson, Maryann E

    2015-10-01

    The Substance Abuse and Mental Health Services Administration (SAMHSA) in the Department of Health and Human Services offers extensive disaster behavior health resources to assist disaster survivors in preparing for, responding to, and recovering from natural and manmade disasters. One of SAMHSA's most innovative resources is the SAMHSA Behavioral Health Disaster Response App (SAMHSA Disaster App). The SAMHSA Disaster App prepares behavioral health responders for any type of traumatic event by allowing them to access disaster-related materials and other key resources right on their phone, at the touch of a button. The SAMHSA Disaster App is available on iPhone, Android, and BlackBerry devices.

  15. App Empire Make Money, Have a Life, and Let Technology Work for You

    CERN Document Server

    Mureta, Chad

    2012-01-01

    A guide to building wealth by designing, creating, and marketing a successful app across any platform Chad Mureta has made millions starting and running his own successful app business, and now he explains how you can do it, too, in this non-technical, easy-to-follow guide. App Empire provides the confidence and the tools necessary for taking the next step towards financial success and freedom. The book caters to many platforms including iPhone, iPad, Android, and BlackBerry. This book includes real-world examples to inspire those who are looking to cash in on the App gold rush. Learn how to s

  16. Putting education in "educational" apps: lessons from the science of learning.

    Science.gov (United States)

    Hirsh-Pasek, Kathy; Zosh, Jennifer M; Golinkoff, Roberta Michnick; Gray, James H; Robb, Michael B; Kaufman, Jordy

    2015-05-01

    Children are in the midst of a vast, unplanned experiment, surrounded by digital technologies that were not available but 5 years ago. At the apex of this boom is the introduction of applications ("apps") for tablets and smartphones. However, there is simply not the time, money, or resources available to evaluate each app as it enters the market. Thus, "educational" apps-the number of which, as of January 2015, stood at 80,000 in Apple's App Store (Apple, 2015)-are largely unregulated and untested. This article offers a way to define the potential educational impact of current and future apps. We build upon decades of work on the Science of Learning, which has examined how children learn best. From this work, we abstract a set of principles for two ultimate goals. First, we aim to guide researchers, educators, and designers in evidence-based app development. Second, by creating an evidence-based guide, we hope to set a new standard for evaluating and selecting the most effective existing children's apps. In short, we will show how the design and use of educational apps aligns with known processes of children's learning and development and offer a framework that can be used by parents and designers alike. Apps designed to promote active, engaged, meaningful, and socially interactive learning-four "pillars" of learning-within the context of a supported learning goal are considered educational.

  17. mHealth App for Cannabis Users: Satisfaction and Perceived Usefulness

    Directory of Open Access Journals (Sweden)

    gregoire eMonney

    2015-08-01

    Full Text Available Objective: The aim of this study was to describe the characteristics of cannabis users and their levels of satisfaction with Stop-cannabis, an app intended for cannabis users who want to stop or reduce their cannabis use or prevent relapse. Methods: A cross-sectional online survey was administered to users of Stop-cannabis, a French-language app for iOS and Android devices. All app users were invited to participate in the survey via a message sent to the app. Results: For hundred and eighty-two users answered the survey. The app was used daily by 348 of the participants (around 70%. More than 80% of participants (397 considered the app to have helped them a little or a lot to stop or reduce cannabis consumption. Most of the users’ suggestions were related to the number or the quality of the messages sent by, or displayed in, the app.Conclusion: This pilot study supports the feasibility of such an app and its perceived usefulness. A self-selection bias however limits the conclusions of the study. The efficacy of the app should be evaluated in a randomized controlled trial.

  18. Mac OS X Lion在Mac App Store上线

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    2011年7月20日,Apple宣布具有超过250种新功能的世界最先进操作系统的第八个重要版本Mac OS X Lion今天在Mac App StoreTM推出并可进行下载,价格为29.99美元。Lion的诸多超强功能包括:全新Multi-Touch手势;全系统支持全屏应用程序;

  19. A mobile app for military operational entomology pesticide applications.

    Science.gov (United States)

    Britch, Seth C; Linthicum, Kenneth J; Aldridge, Robert L; Yans, Matthew W; Hill, David W; Obenauer, Peter J; Hoffman, Eric R

    2014-09-01

    Multiple field studies conducted for the Deployed War-Fighter Protection (DWFP) research program have generated more than 80 specific guidance points for innovative combinations of pesticide application equipment, pesticide formulations, and application techniques for aerosol and residual pesticide treatments in 6 ecological regions against a range of mosquito, sand fly, and filth fly nuisance and disease-vector threats. To synthesize and operationalize these DWFP field and laboratory efficacy data we developed an interactive iOS and Android mobile software application, the Pesticide App, consisting of specific pesticide application guidance organized by environment and target insect vector species. PMID:25843102

  20. Combining playware exergaming with a mobile fitness app

    OpenAIRE

    Giannisakis, Emmanouil; Lund, Henrik Hautop

    2015-01-01

    We propose a novel playware as a merge between exergames and mobile fitness apps to engage the users in physical exercises, not only as competitive play, but also in the form of cooperative play. The concept connects modular interactive tiles with radio communication to Android tablets and smart phones, which can connect to the Internet. This allows the players to monitor their playware exergaming performance on the smart device(s). A test was set up over 8 days allowing two school classes to...

  1. App与自动化%App and Automation

    Institute of Scientific and Technical Information of China (English)

    华镕

    2013-01-01

    iPod给我们带来了iTune音乐商店,iPhone/iPad给我们带来了应用程序(App)商店.目前苹果iOS的App商店与谷歌Android的Play平台都拥有70多万款应用,两者的竞争也日趋白热化.我们今天要讨论的是如何把App应用于工业自动化.

  2. 75 FR 13643 - ITS Joint Program Office; Intelligent Transportation Systems Program Advisory Committee; Notice...

    Science.gov (United States)

    2010-03-22

    ... ITS Joint Program Office; Intelligent Transportation Systems Program Advisory Committee; Notice of... (FACA) (Pub. L. 72-363; 5 U.S.C. app. 2), a meeting of the Intelligent Transportation Systems (ITS... implementation of intelligent transportation systems. Through its sponsor, the ITS Joint Program Office...

  3. 76 FR 51461 - Commercial Space Transportation Advisory Committee-Open Meeting

    Science.gov (United States)

    2011-08-18

    ... TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Open Meeting AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation... Act (Pub. L. 92-463, 5 U.S.C. App. 2), notice is hereby given of a meeting of the Commercial...

  4. Design and Implementation of App Widget Based-on Android Platform%基于Android平台的App Widget设计与实现

    Institute of Scientific and Technical Information of China (English)

    张立敏; 刘卫东; 周全

    2013-01-01

    通过青岛世园会倒计时的设计对App Widget原理及架构进行了研究,并将传统的单一的倒计时功能与控件连接网页功能相结合,进一步完善控件实用性.做了App Widget的概述,介绍了App Widget的加载流程并给出了实例的设计方法以及功能效果图.

  5. Can you build an iPhone app without writing a single line of code?

    Science.gov (United States)

    Ramachandran, R.; Maskey, M.

    2011-12-01

    At the last ESIP summer meeting, a study was conducted to explore different commercial tools now available that allow one to create a mobile app without writing a single line of code. The proposed research comprised of two components. First, systematically evaluate different tools to create mobile apps along the dimensions of features and price. Second, create an iPhone app prototype for the ESIP community using some of these tools. The initial assessment classified the currently available tools to create mobile app tools into two categories. The tools that fall under the first category require no programming, but the content for the mobile apps are fed to it either via a web site RSS feed or entered manually. Consequently, these tools only support limited user interactivity. These tools follow the business model of website hosting services. This business model offers a set of templates to the end users with limited customization features to create their content in order to publish to websites. The second category of tools requires programming, but the code can be written in popular languages such as Javascript (compatible with most mobile platforms) rather than mobile app specific languages. For the second component of the study, two ESIP iPhone app prototypes were created. The first prototype required no programming and used the AppMakr tool. Objective C was used to create the second iPhone prototype from scratch and the source code for this prototype is available on the ESIP website. The study concluded that existing tools do make it easy to create a simple mobile app especially if one already has a well designed website. The associated costs are adequate but not cheap. However, if the mobile app has requirements that require interactivity and specialized customization then one needs to work with a mobile app developer.

  6. APP Is a Context-Sensitive Regulator of the Hippocampal Presynaptic Active Zone.

    Science.gov (United States)

    Laßek, Melanie; Weingarten, Jens; Wegner, Martin; Mueller, Benjamin F; Rohmer, Marion; Baeumlisberger, Dominic; Arrey, Tabiwang N; Hick, Meike; Ackermann, Jörg; Acker-Palmer, Amparo; Koch, Ina; Müller, Ulrike; Karas, Michael; Volknandt, Walter

    2016-04-01

    The hallmarks of Alzheimer's disease (AD) are characterized by cognitive decline and behavioral changes. The most prominent brain region affected by the progression of AD is the hippocampal formation. The pathogenesis involves a successive loss of hippocampal neurons accompanied by a decline in learning and memory consolidation mainly attributed to an accumulation of senile plaques. The amyloid precursor protein (APP) has been identified as precursor of Aβ-peptides, the main constituents of senile plaques. Until now, little is known about the physiological function of APP within the central nervous system. The allocation of APP to the proteome of the highly dynamic presynaptic active zone (PAZ) highlights APP as a yet unknown player in neuronal communication and signaling. In this study, we analyze the impact of APP deletion on the hippocampal PAZ proteome. The native hippocampal PAZ derived from APP mouse mutants (APP-KOs and NexCreAPP/APLP2-cDKOs) was isolated by subcellular fractionation and immunopurification. Subsequently, an isobaric labeling was performed using TMT6 for protein identification and quantification by high-resolution mass spectrometry. We combine bioinformatics tools and biochemical approaches to address the proteomics dataset and to understand the role of individual proteins. The impact of APP deletion on the hippocampal PAZ proteome was visualized by creating protein-protein interaction (PPI) networks that incorporated APP into the synaptic vesicle cycle, cytoskeletal organization, and calcium-homeostasis. The combination of subcellular fractionation, immunopurification, proteomic analysis, and bioinformatics allowed us to identify APP as structural and functional regulator in a context-sensitive manner within the hippocampal active zone network. PMID:27092780

  7. APP Is a Context-Sensitive Regulator of the Hippocampal Presynaptic Active Zone.

    Directory of Open Access Journals (Sweden)

    Melanie Laßek

    2016-04-01

    Full Text Available The hallmarks of Alzheimer's disease (AD are characterized by cognitive decline and behavioral changes. The most prominent brain region affected by the progression of AD is the hippocampal formation. The pathogenesis involves a successive loss of hippocampal neurons accompanied by a decline in learning and memory consolidation mainly attributed to an accumulation of senile plaques. The amyloid precursor protein (APP has been identified as precursor of Aβ-peptides, the main constituents of senile plaques. Until now, little is known about the physiological function of APP within the central nervous system. The allocation of APP to the proteome of the highly dynamic presynaptic active zone (PAZ highlights APP as a yet unknown player in neuronal communication and signaling. In this study, we analyze the impact of APP deletion on the hippocampal PAZ proteome. The native hippocampal PAZ derived from APP mouse mutants (APP-KOs and NexCreAPP/APLP2-cDKOs was isolated by subcellular fractionation and immunopurification. Subsequently, an isobaric labeling was performed using TMT6 for protein identification and quantification by high-resolution mass spectrometry. We combine bioinformatics tools and biochemical approaches to address the proteomics dataset and to understand the role of individual proteins. The impact of APP deletion on the hippocampal PAZ proteome was visualized by creating protein-protein interaction (PPI networks that incorporated APP into the synaptic vesicle cycle, cytoskeletal organization, and calcium-homeostasis. The combination of subcellular fractionation, immunopurification, proteomic analysis, and bioinformatics allowed us to identify APP as structural and functional regulator in a context-sensitive manner within the hippocampal active zone network.

  8. Glial expression of the {beta}-Amyloid Precursor Protein (APP) in global ischemia

    Energy Technology Data Exchange (ETDEWEB)

    Banati, R.B.; Gehrmann, J.; Kreutzberg, G.W. [Max Planck Institute of Psychiarty, Martinsried (Germany)]|[Max Planck Institute for Neurological Research, Koeln (Germany)]|[Univ. Hospital, Zurich (Switzerland)

    1995-07-01

    The {beta}-amyloid precursor protein (APP) bears characteristics of an acute-phase protein and therefore is likely to be involved in the glial response to brain injury. In the brain, APP is rapidly synthesized by activated glial cells in response to comparatively mild neuronal lesions, e.g., a remote peripheral nerve injury. Perfusion deficits in the brain result largely in neuronal necrosis and are a common condition in elderly patients. This neuronal necrosis is accompanied by a pronounced reaction of astrocytes and microglia, which can also be observed in animal models. We have therefore studied in the rat, immunocytochemically, the induction of APP after 30 min of global ischemia caused by four-vessel occlusion. The postischemic brain injuries were examined at survival times from 12 h to 7 days. From day 3 onward, APP immunoreactivity was strongly induced in the CA{sub 1} and CA{sub 4} regions of the rat dorsal hippocampus as well as in the dorsolateral striatum. In these areas, the majority of APP-immunoreactive cells were reactive glial fibrillary acidic protein (GFAP)-positive astrocytes, as shown by double-immunofluorescence labeling for GFAP and APP. Additionally, small ramified cells, most likely activated microglia, expressed APP immunoreactivity. In contrast, in the parietal cortex, APP immunoreactivity occurred focally in clusters of activated microglia rather than in astrocytes, as demonstrated by double-immunofluorescence labeling for APP and the microglia-binding lectin Griffonia simplicifolia isolectin B{sub 4}. In conclusion, following global ischemia, APP is induced in reactive glial cells with spatial differences in the distribution pattern of APP induction in actrocytes and microglia. 51 refs., 4 figs.

  9. Mental Health Mobile Apps: From Infusion to Diffusion in the Mental Health Social System.

    Science.gov (United States)

    East, Marlene Lynette; Havard, Byron C

    2015-01-01

    The roles of mental health educators and professionals in the diffusion of mental health mobile apps are addressed in this viewpoint article. Mental health mobile apps are emerging technologies that fit under the broad heading of mobile health (mHealth). mHealth, encompassed within electronic health (eHealth), reflects the use of mobile devices for the practice of public health. Well-designed mental health mobile apps that present content in interactive, engaging, and stimulating ways can promote cognitive learning, personal growth, and mental health enhancement. As key influencers in the mental health social system, counselor educators and professional associations may either help or hinder diffusion of beneficial mHealth technologies. As mental health mobile apps move towards ubiquity, research will continue to be conducted. The studies published thus far, combined with the potential of mental health mobile apps for learning and personal growth, offer enough evidence to compel mental health professionals to infuse these technologies into education and practice. Counselor educators and professional associations must use their influential leadership roles to train students and practitioners in how to research, evaluate, and integrate mental health mobile apps into practice. The objectives of this article are to (1) increase awareness of mHealth and mental health mobile apps, (2) demonstrate the potential for continued growth in mental health mobile apps based on technology use and acceptance theory, mHealth organizational initiatives, and evidence about how humans learn, (3) discuss evidence-based benefits of mental health mobile apps, (4) examine the current state of mHealth diffusion in the mental health profession, and (5) offer solutions for impelling innovation diffusion by infusing mental health mobile apps into education, training, and clinical settings. This discussion has implications for counselor educators, mental health practitioners, associations

  10. The Impact of Large Scale Promotions on the Sales and Ratings of Mobile Apps: Evidence from Apple's App Store

    OpenAIRE

    Askalidis, Georgios

    2015-01-01

    We study four promotions offered on Apple's mobile app store that vary in user exposure, price discount and redemption procedure. We find that promotions that are full-price discounted and digital (i.e., the redemption procedure is a few taps on the smartphone) are the ones that cause the largest increase in downloads. Investigating the effect on ratings, we find neutral or positive effects on the ratings for all full-price discounted promotions but negative short-term effects on the ratings ...

  11. Earth Science Mobile App Development for Non-Programmers

    Science.gov (United States)

    Oostra, D.; Crecelius, S.; Lewis, P.; Chambers, L. H.

    2012-08-01

    A number of cloud based visual development tools have emerged that provide methods for developing mobile applications quickly and without previous programming experience. The MY NASA DATA (MND) team would like to begin a discussion on how we can best leverage current mobile app technologies and available Earth science datasets. The MY NASA DATA team is developing an approach based on two main ideas. The first is to teach our constituents how to create mobile applications that interact with NASA datasets; the second is to provide web services or Application Programming Interfaces (APIs) that create sources of data that educators, students and scientists can use in their own mobile app development. This framework allows data providers to foster mobile application development and interaction while not becoming a software clearing house. MY NASA DATA's research has included meetings with local data providers, educators, libraries and individuals. A high level of interest has been identified from initial discussions and interviews. This overt interest combined with the marked popularity of mobile applications in our societies has created a new channel for outreach and communications with and between the science and educational communities.

  12. Distributed Hydrologic Modeling Apps for Decision Support in the Cloud

    Science.gov (United States)

    Swain, N. R.; Latu, K.; Christiensen, S.; Jones, N.; Nelson, J.

    2013-12-01

    Advances in computation resources and greater availability of water resources data represent an untapped resource for addressing hydrologic uncertainties in water resources decision-making. The current practice of water authorities relies on empirical, lumped hydrologic models to estimate watershed response. These models are not capable of taking advantage of many of the spatial datasets that are now available. Physically-based, distributed hydrologic models are capable of using these data resources and providing better predictions through stochastic analysis. However, there exists a digital divide that discourages many science-minded decision makers from using distributed models. This divide can be spanned using a combination of existing web technologies. The purpose of this presentation is to present a cloud-based environment that will offer hydrologic modeling tools or 'apps' for decision support and the web technologies that have been selected to aid in its implementation. Compared to the more commonly used lumped-parameter models, distributed models, while being more intuitive, are still data intensive, computationally expensive, and difficult to modify for scenario exploration. However, web technologies such as web GIS, web services, and cloud computing have made the data more accessible, provided an inexpensive means of high-performance computing, and created an environment for developing user-friendly apps for distributed modeling. Since many water authorities are primarily interested in the scenario exploration exercises with hydrologic models, we are creating a toolkit that facilitates the development of a series of apps for manipulating existing distributed models. There are a number of hurdles that cloud-based hydrologic modeling developers face. One of these is how to work with the geospatial data inherent with this class of models in a web environment. Supporting geospatial data in a website is beyond the capabilities of standard web frameworks and it

  13. Geosocial-Networking App Usage Patterns of Gay, Bisexual, and Other Men Who Have Sex With Men: Survey Among Users of Grindr, A Mobile Dating App

    OpenAIRE

    William C Goedel; Duncan, Dustin T

    2015-01-01

    Background Geosocial-networking apps like Grindr have been used increasingly among men who have sex with men (MSM) to meet anonymous partners. These mobile dating apps employ global positioning system technology to facilitate connections with other users based on their current location. These new technologies have generated quicker and easier modes for men who have sex with men to meet potential partners based on attraction and physical proximity. Objective The aim of this study is to describ...

  14. Mobile Apps for Reflection in Learning: A Design Research in K-12 Education

    Science.gov (United States)

    Leinonen, Teemu; Keune, Anna; Veermans, Marjaana; Toikkanen, Tarmo

    2016-01-01

    This study takes a design-based research approach to explore how applications designed for mobile devices could support reflection in learning in K-12 education. Use of mobile devices is increasing in schools. Most of the educational apps support single-person use of interactive learning materials, simulations and learning games. Apps designed to…

  15. The Use of Mobile Apps to Enhance Student Learning in Introduction to Psychology

    Science.gov (United States)

    Diliberto-Macaluso, Kristen; Hughes, Alan

    2016-01-01

    The current study examined the impact of mobile applications or apps on student learning in an introduction to psychology course. Students were assigned to complete a learner-centered worksheet activity on the brain and central nervous system using either an interactive 3-D Brain app or their online course textbook. We measured student learning…

  16. Combining apps targeting professionals and senior citizens to improve housing accessibility and influence housing provision policies

    DEFF Research Database (Denmark)

    Helle, Tina; Iwarsson, Susanne; Lunn, Tine Bieber;

    2015-01-01

    Two separate apps that address the increasingly important issue of accessible housing for senior citizens have been developed in different project settings. One of the apps was developed to facilitate the process for professional raters to assess housing accessibility in the context of individual...... and influence housing provision policies....

  17. Content Analysis of Diet-Related Mobile Apps: A Self-Regulation Perspective.

    Science.gov (United States)

    Zahry, Nagwan R; Cheng, Ying; Peng, Wei

    2016-10-01

    Diet-related mobile apps hold promise in helping individuals self-regulate their eating behaviors. Nevertheless, little is known about the extent to which diet-related mobile apps incorporate the established behavior change theories and evidence-based practices that promote dietary self-regulation. Guided by the self-regulation aspect of Bandura's social cognitive theory and the Dietary Guidelines for Americans 2010 of the U.S. Department of Agriculture, this study conducts a content analysis of diet-related mobile apps for iPhone (N = 400). In terms of the adherence to the self-regulation aspect of the social cognitive theory, results show that although 72.5% of the apps incorporate at least one theoretical construct, few apps tap all three processes of self-regulation (i.e., self-observation/monitoring, judgment process, and self-reaction). Additionally, outcome expectation is manifested in a majority of the diet-related apps. In terms of the Dietary Guidelines for Americans 2010, while the diet-related apps equally emphasize setting goals for calorie intake or nutrient consumption, more apps feature nutrient tracking than calorie tracking. Implications and limitations are discussed.

  18. WhatsApp Goes to School: Mobile Instant Messaging between Teachers and Students

    Science.gov (United States)

    Bouhnik, Dan; Deshen, Mor

    2014-01-01

    WhatsApp is a Smartphone application for instant messaging. Lately the application's popularity has risen. One of the unique features of the application is its ability to enhance communication within a group. Classroom communication between teaching faculty and high school students using WhatsApp has not yet, to our knowledge, been researched…

  19. mHealth in urology : A review of experts' involvement in app development

    NARCIS (Netherlands)

    Pereira-Azevedo, N. (Nuno); Carrasquinho, E. (Eduardo); De Oliveira, E.C. (Eduardo Cardoso); Cavadas, V. (Vitor); Osório, L. (Luís); Fraga, A. (Avelino); Castelo-Branco, M. (Miguel); Roobol, M.J. (Monique J.)

    2015-01-01

    textabstractIntroduction: Smartphones are increasingly playing a role in healthcare and previous studies assessing medical applications (apps) have raised concerns about lack of expert involvement and low content accuracy. However, there are no such studies in Urology. We reviewed Urology apps with

  20. Designing web-apps for smartphones can be easy as making slideshow presentations

    DEFF Research Database (Denmark)

    Subhi, Yousif; Todsen, Tobias; Ringsted, Charlotte;

    2014-01-01

    BACKGROUND: Limited clinician involvement in smartphone application development poses problems considering the extensive use of smartphones among medical professionals and patients. FINDINGS: We present a simple method for the clinician to develop simple web-apps using only an Internet browser...... and a text editor. CONCLUSIONS: This method may help clinicians develop simple web-apps and increase clinician involvement in smartphone content....

  1. Mobile App Design for Teaching and Learning: Educators' Experiences in an Online Graduate Course

    Science.gov (United States)

    Hsu, Yu-Chang; Ching, Yu-Hui

    2013-01-01

    This research explored how educators with limited programming experiences learned to design mobile apps through peer support and instructor guidance. Educators were positive about the sense of community in this online course. They also considered App Inventor a great web-based visual programming tool for developing useful and fully functioning…

  2. Exploring the Application of a Conceptual Framework in a Social MALL App

    Science.gov (United States)

    Read, Timothy; Bárcena, Elena; Kukulska-Hulme, Agnes

    2016-01-01

    This article presents a prototype social Mobile Assisted Language Learning (henceforth, MALL) app based on Kukulska-Hulme's (2012) conceptual framework. This research allows the exploration of time, place and activity type as key factors in the design of MALL apps, and is the first step toward a systematic analysis of such a framework in this type…

  3. Information Use and Barriers on a Mobile App in Distance Learning

    Science.gov (United States)

    Du, Yunfei

    2015-01-01

    Mobile technologies such as iPhone apps make it possible for learners to freely access course content management systems, library Web sites, as well as reference services from anywhere, anytime. This paper reviewed the current status of mobile learning and suggested possible factors influencing the use of mobile apps in online learning. The author…

  4. A Systematic Review of Cognitive Behavioral Therapy and Behavioral Activation Apps for Depression.

    Science.gov (United States)

    Huguet, Anna; Rao, Sanjay; McGrath, Patrick J; Wozney, Lori; Wheaton, Mike; Conrod, Jill; Rozario, Sharlene

    2016-01-01

    Depression is a common mental health condition for which many mobile apps aim to provide support. This review aims to identify self-help apps available exclusively for people with depression and evaluate those that offer cognitive behavioural therapy (CBT) or behavioural activation (BA). One hundred and seventeen apps have been identified after searching both the scientific literature and the commercial market. 10.26% (n = 12) of these apps identified through our search offer support that seems to be consistent with evidence-based principles of CBT or BA. Taking into account the non existence of effectiveness/efficacy studies, and the low level of adherence to the core ingredients of the CBT/BA models, the utility of these CBT/BA apps are questionable. The usability of reviewed apps is highly variable and they rarely are accompanied by explicit privacy or safety policies. Despite the growing public demand, there is a concerning lack of appropiate CBT or BA apps, especially from a clinical and legal point of view. The application of superior scientific, technological, and legal knowledge is needed to improve the development, testing, and accessibility of apps for people with depression. PMID:27135410

  5. Apps4CPR: A review study of mobile applications for cardiopulmonary resuscitation training and support

    NARCIS (Netherlands)

    Kalz, Marco

    2013-01-01

    Kalz, M. (2013, 23 September). Apps4CPR: A review study of mobile applications for cardiopulmonary resuscitation training and support. Presentation given during the 6th World Congress on Social Media, Mobile Apps and Internet/Web 2.0 in Medicine, Health, and Biomedical Research, London, UK.

  6. Using Math Apps for Improving Student Learning: An Exploratory Study in an Inclusive Fourth Grade Classroom

    Science.gov (United States)

    Zhang, Meilan; Trussell, Robert P.; Gallegos, Benjamin; Asam, Rasmiyeh R.

    2015-01-01

    Recent years have seen a quick expansion of tablet computers in households and schools. One of the educational affordances of tablet computers is using math apps to engage students in mathematics learning. However, given the short history of the mobile devices, little research exists on the effectiveness of math apps, particularly for struggling…

  7. Impact of Contextuality on Mobile Learning Acceptance: An Empirical Study Based on a Language Learning App

    Science.gov (United States)

    Böhm, Stephan; Constantine, Georges Philip

    2016-01-01

    Purpose: This paper aims to focus on contextualized features for mobile language learning apps. The scope of this paper is to explore students' perceptions of contextualized mobile language learning. Design/Methodology/Approach: An extended Technology Acceptance Model was developed to analyze the effect of contextual app features on students'…

  8. The electronic Discharge Letter Mobile App - The London man who went to the Tokio Olympics

    NARCIS (Netherlands)

    Lezcano, Leonardo; Ternier, Stefaan; Drachsler, Hendrik; Kalz, Marco; Specht, Marcus

    2013-01-01

    Lezcano, L., Ternier, S., Drachsler, H., Kalz, M., & Specht, M. (2013, September). The Electronic Discharge Letter Mobile App - The London man who went to the Tokio Olympics. Presentation at MEDICINE 2.0: 6th World Congress on Social Media, Mobile Apps, Internet/Web 2.0, London, England.

  9. Content Analysis of Diet-Related Mobile Apps: A Self-Regulation Perspective.

    Science.gov (United States)

    Zahry, Nagwan R; Cheng, Ying; Peng, Wei

    2016-10-01

    Diet-related mobile apps hold promise in helping individuals self-regulate their eating behaviors. Nevertheless, little is known about the extent to which diet-related mobile apps incorporate the established behavior change theories and evidence-based practices that promote dietary self-regulation. Guided by the self-regulation aspect of Bandura's social cognitive theory and the Dietary Guidelines for Americans 2010 of the U.S. Department of Agriculture, this study conducts a content analysis of diet-related mobile apps for iPhone (N = 400). In terms of the adherence to the self-regulation aspect of the social cognitive theory, results show that although 72.5% of the apps incorporate at least one theoretical construct, few apps tap all three processes of self-regulation (i.e., self-observation/monitoring, judgment process, and self-reaction). Additionally, outcome expectation is manifested in a majority of the diet-related apps. In terms of the Dietary Guidelines for Americans 2010, while the diet-related apps equally emphasize setting goals for calorie intake or nutrient consumption, more apps feature nutrient tracking than calorie tracking. Implications and limitations are discussed. PMID:26940817

  10. Exergame Apps and Physical Activity: The Results of the ZOMBIE Trial

    Science.gov (United States)

    Cowdery, Joan; Majeske, Paul; Frank, Rebecca; Brown, Devin

    2015-01-01

    Background: Although there are thousands of health and fitness smartphone apps currently available, little research exists regarding the effects of mobile app technology on physical activity behavior. Purpose: The purpose of this study was to test whether Exergame smartphone applications increase physical activity levels. Methods: This was a…

  11. A Framework for Mobile Apps in Colleges and Universities: Data Mining Perspective

    Science.gov (United States)

    Singh, Archana; Ranjan, Jayanthi

    2016-01-01

    The Enterprise mobility communication technology provides easy and quick accessibility to data and information integrated into one single touch point device. This device incorporates or integrates all the processes into small applications or App and thus increases the workforce capability of knowledge workers. "App" which is a small set…

  12. From Cloud to Mobile: Drawing down Big Info into Little Apps

    Science.gov (United States)

    Herther, Nancy K.

    2011-01-01

    With the release of Google's App Inventor for Android, though still officially in beta, the company sought to make app development "simple but powerful" so that teachers could create study tips and quizzes, anyone could create geographic information systems (GIS) to help people find their way to some destination, and people could communicate over…

  13. App use, physical activity and healthy lifestyle: a cross sectional study

    NARCIS (Netherlands)

    Dallinga, Joan Martine; Mennes, Matthijs; Alpay, Laurence; Bijwaard, Harmen; Baart de la Faille-Deutekom, Marije

    2015-01-01

    Eind November is het Serious Health Games and Apps Symposium gepland in Gent. Dit is de paper die daar gepresenteerd zal worden. Purpose: Physical inactivity is a growing public health concern. There is need for innovative ways to promote physical activity and a healthy lifestyle. Use of mobile app

  14. Why mobile health app overload drives us crazy, and how to restore the sanity

    NARCIS (Netherlands)

    Velsen, van Lex; Beaujean, Desirée J.M.A.; Gemert-Pijnen, van Julia E.W.C.

    2013-01-01

    Background Smartphones and tablet computers have become an integral part of our lives. One of their key features is the possibility of installing third-party apps. These apps can be very helpful for improving health and healthcare. However, medical professionals and citizens are currently being ove

  15. Smartphone Apps for Cardiopulmonary Resuscitation Training and Real Incident Support: A Mixed-Methods Evaluation Study

    NARCIS (Netherlands)

    Kalz, Marco; Lenssen, Niklas; Felzen, Marco; Rossaint, Rolf; Tabuenca, Bernardo; Specht, Marcus; Skorning, Max

    2014-01-01

    Background: No systematic evaluation of smartphone/mobile apps for resuscitation training and real incident support is available to date. To provide medical, usability, and additional quality criteria for the development of apps, we conducted a mixed-methods sequential evaluation combining the persp

  16. There’s an App for That? Highlighting the Difficulty in Finding Clinically Relevant Smartphone Applications

    Directory of Open Access Journals (Sweden)

    Warren Wiechmann, MD, MBA

    2016-03-01

    Full Text Available Introduction: The use of personal mobile devices in the medical field has grown quickly, and a large proportion of physicians use their mobile devices as an immediate resource for clinical decisionmaking, prescription information and other medical information. The iTunes App Store (Apple, Inc. contains approximately 20,000 apps in its “Medical” category, providing a robust repository of resources for clinicians; however, this represents only 2% of the entire App Store. The App Store does not have strict criteria for identifying content specific to practicing physicians, making the identification of clinically relevant content difficult. The objective of this study is to quantify the characteristics of existing medical applications in the iTunes App Store that could be used by emergency physicians, residents, or medical students. Methods: We found applications related to emergency medicine (EM by searching the iTunes App Store for 21 terms representing core content areas of EM, such as “emergency medicine,” “critical care,” “orthopedics,” and “procedures.” Two physicians independently reviewed descriptions of these applications in the App Store and categorized each as the following: Clinically Relevant, Book/ Published Source, Non-English, Study Tools, or Not Relevant. A third physician reviewer resolved disagreements about categorization. Descriptive statistics were calculated. Results: We found a total of 7,699 apps from the 21 search terms, of which 17.8% were clinical, 9.6% were based on a book or published source, 1.6% were non-English, 0.7% were clinically relevant patient education resources, and 4.8% were study tools. Most significantly, 64.9% were considered not relevant to medical professionals. Clinically relevant apps make up approximately 6.9% of the App Store’s “Medical” Category and 0.1% of the overall App Store. Conclusion: Clinically relevant apps represent only a small percentage (6.9% of the total App

  17. 基于 App Inventor 的智能手表设计%The Design of Smart Watches Based on App Inventor

    Institute of Scientific and Technical Information of China (English)

    孙秀婷; 高迎霞; 丘文辉

    2016-01-01

    This paper designed a multi-function smart watch with AVR series MCU as the core,using visual programming tools MIT App Inventor to design smart watch Android App,using Bluetooth commu-nication technology to realize communication between smart watch and Android mobile phone,through the mobile phone App to manage and set up the smart watch.The smart watch can realize SMS (short message service)and calls reminding,timing,compass,human health testing,and other functions.%以 AVR 系列单片机为核心,设计了一款多功能智能手表。利用可视化编程工具 MIT App Inventor设计智能手表的 Android 手机 App,利用蓝牙通讯技术实现智能手表与 Android 手机之间的通信,通过手机的App 对智能手表进行管理和设置。系统可以实现手机短信和来电提醒、时间计时、指南针、人体健康检测等功能。

  18. Colorimetric evaluation of iPhone apps for colour vision tests based on the Ishihara test.

    Science.gov (United States)

    Dain, Stephen J; AlMerdef, Ali

    2016-05-01

    Given the versatility of smart phone displays, it was inevitable that applications (apps) providing colour vision testing would appear as an option. In this study, the colorimetric characteristics of five available iPhone apps for colour vision testing are assessed as a prequel to possible clinical evaluation. The colours of the displays produced by the apps are assessed with reference to the colours of a printed Ishihara test. The visual task is assessed on the basis of the colour differences and the alignment to the dichromatic confusion lines. The apps vary in quality and while some are colorimetrically acceptable, there are also some problems with their construction in making them a clinically useful app rather than curiosity driven self-testing. There is no reason why, in principle, a suitable test cannot be designed for smart phones. PMID:27146711

  19. Behaviour Change Techniques embedded in health and lifestyle apps: coding and analysis.

    Directory of Open Access Journals (Sweden)

    Gaston Antezana

    2015-09-01

    Full Text Available Background There is evidence showing that commercially available health and lifestyle apps can be used as co-adjuvants to clinical interventions and for the prevention of chronic and non-communicable diseases. This can be particularly significant to support and improve wellbeing of young people given their familiarity with these resources. However it is important to understand the content and consistency of Behaviour Change Techniques (BCT’s embedded in the apps to maximise their potential benefits. Objectives This study explores the BCT content of a selected list of health and lifestyle tracking apps in three behavioural dimensions: physical activity, sleep and diet. We identified BCT commonalities within and between categories to detect the most frequently used and arguably more effective techniques in the context of wellbeing and promotion of health behaviours. Methods Apps were selected by using keywords and by reviewing the “health and fitness” category of GooglePlay (477 apps. The selection criteria included free apps (even if they also offered paid versions and being common to GooglePlay and AppStore. A background review of each app was also completed. Selected apps were classified according to user ratings in GooglePlay (apps with less that 4+ star ratings were disregarded. The top ten apps in each category were selected, making it a total of 30 for the analysis. Three coders used the apps for two months and were trained to use a comprehensive 93 items taxonomy (BCTv1 to complete the analysis. Results Strong BCT similarities were found across all three categories, suggesting a consistent basic content composition. Out of all 93 BCTS’s 8 were identified as being present in at least 50% of the apps. 6 of these BCT’s are concentrated in categories “1. Goals and Planning” and “2. Feedback and Monitoring”. BCT “Social support (unspecified” was coded for in 63% of the apps, as it was present through different features in

  20. Learning by Doing: How to Develop a Cross-Platform Web App

    Directory of Open Access Journals (Sweden)

    Minh Q. Huynh

    2015-06-01

    Full Text Available As mobile devices become prevalent, there is always a need for apps.  How hard is it to develop an app especially a cross-platform app? The paper shares an experience in a project involved the development of a student services web app that can be run on cross-platform mobile devices.  The paper first describes the background of the project, the clients, and the proposed solution.  Then, it focuses on the step-by-step development processes and provides the illustration of written codes and techniques used.  The goal is for readers to gain an understanding on how to develop a mobile-friendly web app.  The paper concludes with teaching implications and offers thoughts for further development.

  1. User Perception of Facebook App Data Access: A Comparison of Methods and Privacy Concerns

    Directory of Open Access Journals (Sweden)

    Jennifer Golbeck

    2016-03-01

    Full Text Available Users share vast amounts of personal information online, but are they fully aware of what information they are sharing and with whom? In this paper, we focused on Facebook apps and set out to understand how concerned users are about privacy and how well-informed they are about what personal data apps can access. We found that initially, subjects were generally under-informed about what data apps could access from their profiles. After viewing additional information about these permissions, subjects’ concern about privacy on Facebook increased. Subjects’ understanding of what data apps were able to access increased, although even after receiving explicit information on the topic, many subjects still did not fully understand the extent to which apps could access their data.

  2. Colorimetric evaluation of iPhone apps for colour vision tests based on the Ishihara test.

    Science.gov (United States)

    Dain, Stephen J; AlMerdef, Ali

    2016-05-01

    Given the versatility of smart phone displays, it was inevitable that applications (apps) providing colour vision testing would appear as an option. In this study, the colorimetric characteristics of five available iPhone apps for colour vision testing are assessed as a prequel to possible clinical evaluation. The colours of the displays produced by the apps are assessed with reference to the colours of a printed Ishihara test. The visual task is assessed on the basis of the colour differences and the alignment to the dichromatic confusion lines. The apps vary in quality and while some are colorimetrically acceptable, there are also some problems with their construction in making them a clinically useful app rather than curiosity driven self-testing. There is no reason why, in principle, a suitable test cannot be designed for smart phones.

  3. SamenStarten App ter ondersteuning van gesprek in de JGZ in Nederland: implementatie in gang [Implementation of StartingTogether App supporting preventive youth health care in the Netherlands

    NARCIS (Netherlands)

    Blanson Henkemans, O.; Keij, M.; Beckers, M.; Kamphuis, M.

    2015-01-01

    De SamenStarten App is ontwikkeld ter ondersteuning van het gesprek tussen jeugdverpleegkundigen en ouders tijdens het huisbezoek. Met de App verloopt het gesprek gestructureerd en krijgt de ouder meer verantwoordelijkheid. Dit artikel bespreekt een landelijk implementatietraject van de App. Het res

  4. User Preferences and Design Recommendations for an mHealth App to Promote Cystic Fibrosis Self-Management

    OpenAIRE

    Hilliard, Marisa E.; Hahn, Amy; Ridge, Alana K; Eakin, Michelle N.; Riekert, Kristin A

    2014-01-01

    Background mHealth apps hold potential to provide automated, tailored support for treatment adherence among individuals with chronic medical conditions. Yet relatively little empirical research has guided app development and end users are infrequently involved in designing the app features or functions that would best suit their needs. Self-management apps may be particularly useful for people with chronic conditions like cystic fibrosis (CF) that have complex, demanding regimens. Objective T...

  5. The Ames dwarf mutation attenuates Alzheimer's disease phenotype of APP/PS1 mice.

    Science.gov (United States)

    Puig, Kendra L; Kulas, Joshua A; Franklin, Whitney; Rakoczy, Sharlene G; Taglialatela, Giulio; Brown-Borg, Holly M; Combs, Colin K

    2016-04-01

    APP/PS1 double transgenic mice expressing human mutant amyloid precursor protein (APP) and presenilin-1 (PS1) demonstrate robust brain amyloid beta (Aβ) peptide containing plaque deposition, increased markers of oxidative stress, behavioral dysfunction, and proinflammatory gliosis. On the other hand, lack of growth hormone, prolactin, and thyroid-stimulating hormone due to a recessive mutation in the Prop 1 gene (Prop1df) in Ames dwarf mice results in a phenotype characterized by potentiated antioxidant mechanisms, improved learning and memory, and significantly increased longevity in homozygous mice. Based on this, we hypothesized that a similar hormone deficiency might attenuate disease changes in the brains of APP/PS1 mice. To test this idea, APP/PS1 mice were crossed to the Ames dwarf mouse line. APP/PS1, wild-type, df/+, df/df, df/+/APP/PS1, and df/df/APP/PS1 mice were compared at 6 months of age through behavioral testing and assessing amyloid burden, reactive gliosis, and brain cytokine levels. df/df mice demonstrated lower brain growth hormone and insulin-like growth factor 1 concentrations. This correlated with decreased astrogliosis and microgliosis in the df/df/APP/PS1 mice and, surprisingly, reduced Aβ plaque deposition and Aβ 1-40 and Aβ 1-42 concentrations. The df/df/APP/PS1 mice also demonstrated significantly elevated brain levels of multiple cytokines in spite of the attenuated gliosis. These data indicate that the df/df/APP/PS1 line is a unique resource in which to study aging and resistance to disease and suggest that the affected pituitary hormones may have a role in regulating disease progression. PMID:26973101

  6. Development of a virtual patient record mobile app for pharmacy practice education

    Directory of Open Access Journals (Sweden)

    Terry Weiyi Toh

    2014-01-01

    Full Text Available Introduction: Healthcare students are generally not exposed in the school curriculum to the workings of electronic health records (EHRs and the types of patient health information (PHI from EHRs that are relevant to clinical practices. A prototype virtual patient record (VPR mobile app was created on two Samsung Galaxy Tab tablets to educate pharmacy students on the types of PHI available from EHRs. Materials and Methods: A pilot study was conducted from March-April 2013, whereby students used the app to solve counseling case scenarios. Respondents′ demographics, mobile app usage patterns, perceptions regarding the app′s usefulness, and its relevance as an EHR simulation tool, were determined through an online 14-item survey. Descriptive statistics, Chi-square tests, Fisher′s exact tests and Mann-Whitney U tests were used to analyze the results. Results: Response rate was 100% (n = 31. Medical and healthcare apps were most commonly used (93.5%, and 67.7% of students used apps more than 5 times a day over the past 6 months. The app had 4 features ("PHR", "Case Questions", "Statutes" and "Useful Links". Most students felt that the app features were understandable and self-explanatory (96.7%. Majority agreed that "PHR" (100% and "Case Questions" (83.9% were the most useful features. Majority (90.3% found the app useful as a teaching aid. Conclusion: A VPR app has been successfully created and implemented as a teaching aid. Future development will involve migrating its features to the mobile web. Resources for health-related and medication-related information will be added. Furthermore, the app will be introduced to lower-year undergraduates before their hospital preceptorship attachments.

  7. (IN-PRIVACY IN MOBILE APPS. CUSTOMER OPPORTUNITIES

    Directory of Open Access Journals (Sweden)

    Yu.S. Chemerkina

    2016-01-01

    Full Text Available Subject of Study. The paper presents the results of an investigation of cross-platform mobile applications. This paper focuses on a cross-platform app data investigation in purpose of creating a database that helps to make decisions from data privacy viewpoint. These decisions refer to knowledge about mobile apps that are available to the public, especially on how consumer data is protected while it is stored locally or transferred via network as well as what type of data may leak. Methods. This paper proposes a forensics methodology as a cornerstone of an app data investigation process. The object of research is an application data protection under different security control types among modern mobile OS. The subject of research is a modification of forensics approach and behavioral analysis to examine application data privacy in order to find data that are not properly handled by applications which lead to data leakages, defining protection control type without forensics limits. In addition, this paper relies on using the simplest tools, proposing a limit to examine locally stored data and transmitted over the network to cover all data, excluding memory and code analysis unless it is valuable (behavioral analysis. The research methods of the tasks set in the paper include digital forensics approach methods depending on data conception (at-rest, in-use/memory, in-transit with behavioral analysis of application, and static and dynamic application code analysis. Main Results. The research was carried out for the scope of that thesis, and the following scientific results were obtained. First, the methods used to investigate the privacy of application data allow considering application features and protection code design and flaws in the context of incomplete user awareness about the privacy state due to external activity of the developer. Second, the knowledge set about facts of application data protection that allows making a knowledge database to

  8. 77 FR 8837 - Publication of Housing Price Inflation Adjustment Under 50 U.S.C. App. § 531

    Science.gov (United States)

    2012-02-15

    ... of the Secretary Publication of Housing Price Inflation Adjustment Under 50 U.S.C. App. Sec. 531... Servicemembers Civil Relief Act, as codified at 50 U.S.C. App. Sec. 531, prohibits a landlord from evicting a... index required by the statute. The maximum monthly rental amount for 50 U.S.C. App. Sec. 531...

  9. A Comparison of Teacher Assessment (APP) with Standardised Tests in Primary Literacy and Numeracy (WIAT-II)

    Science.gov (United States)

    Marlow, Ruth; Norwich, Brahm; Ukoumunne, Obioha C.; Hansford, Lorraine; Sharkey, Siobhan; Ford, Tamsin

    2014-01-01

    Assessing Pupils' Progress (APP) arose from a government drive to increase the amount of teacher-based assessment within school and to make this consistent across schools. We conducted semi-structured interviews with head teachers to gain insight into how their schools applied APP and we compared the APP levels for English and Maths, provided…

  10. 78 FR 9678 - Publication of Housing Price Inflation Adjustment Under 50 U.S.C. App. § 531

    Science.gov (United States)

    2013-02-11

    ... of the Secretary Publication of Housing Price Inflation Adjustment Under 50 U.S.C. App. Sec. 531... Servicemembers Civil Relief Act, as codified at 50 U.S.C. App. Sec. 531, prohibits a landlord from evicting a... index required by the statute. The maximum monthly rental amount for 50 U.S.C. App. Sec. 531...

  11. 75 FR 12518 - Publication of Housing Price Inflation Adjustment Under 50 U.S.C. App. 531

    Science.gov (United States)

    2010-03-16

    ... of the Secretary Publication of Housing Price Inflation Adjustment Under 50 U.S.C. App. 531 AGENCY... Civil Relief Act, as codified at 50 U.S.C. App. 531, prohibits a landlord from evicting a servicemember... the statute. The maximum monthly rental amount for 50 U.S.C. App. 531(a)(1)(A)(ii) as of January...

  12. Learning Discloses Abnormal Structural and Functional Plasticity at Hippocampal Synapses in the APP23 Mouse Model of Alzheimer's Disease

    Science.gov (United States)

    Middei, Silvia; Roberto, Anna; Berretta, Nicola; Panico, Maria Beatrice; Lista, Simone; Bernardi, Giorgio; Mercuri, Nicola B.; Ammassari-Teule, Martine; Nistico, Robert

    2010-01-01

    B6-Tg/Thy1APP23Sdz (APP23) mutant mice exhibit neurohistological hallmarks of Alzheimer's disease but show intact basal hippocampal neurotransmission and synaptic plasticity. Here, we examine whether spatial learning differently modifies the structural and electrophysiological properties of hippocampal synapses in APP23 and wild-type mice. While…

  13. Building a Library App Portfolio with Redis and Django

    Directory of Open Access Journals (Sweden)

    Jeremy Nelson

    2013-01-01

    Full Text Available The Tutt Library at Colorado College is developing a portfolio of library applications for use by patrons and library staff. Developed under an iterative and incremental agile model, these single-use HTML5 applications target multiple devices while using Bootstrap and Django to deliver fast and responsive interfaces to underlying FRBR datastores running on Redis, an advanced NoSQL database server. Two types are delineated: applications for access and discovery, which are available to everyone; and productivity applications, which are primarily for library staff to administer and manage the FRBR-RDA records. The access portfolio includes Book Search, Article Search, Call Number, and Library Hours applications. The productivity side includes an Orders App and a MARC Batch application for ingesting MARC records as FRBR entities using RDA Core attributes. When a critical threshold is reached, the Tutt Library intends to replace its legacy ILS with this library application portfolio.

  14. ISBN and QR Barcode Scanning Mobile App for Libraries

    Directory of Open Access Journals (Sweden)

    Graham McCarthy

    2011-04-01

    Full Text Available This article outlines the development of a mobile application for the Ryerson University Library. The application provides for ISBN barcode scanning that results in a lookup of library copies and services for the book scanned, as well as QR code scanning. Two versions of the application were developed, one for iOS and one for Android. The article includes some details on the free packages used for barcode scanning functionality. Source code for the Ryerson iOS and Android applications are freely available, and instructions are provided on customizing the Ryerson application for use in other library environments. Some statistics on the number of downloads of the Ryerson mobile app by users are included.

  15. LESSONS LEARNED Biosurveillance Mobile App Development Intern Competition (Summer 2013)

    Energy Technology Data Exchange (ETDEWEB)

    Noonan, Christine F.; Henry, Michael J.; Corley, Courtney D.

    2014-01-14

    The purpose of the lessons learned document for the BEOWulf Biosurveillance Mobile App Development Intern Competition is to capture the project’s lessons learned in a formal document for use by other project managers on similar future projects. This document may be used as part of new project planning for similar projects in order to determine what problems occurred and how those problems were handled and may be avoided in the future. Additionally, this document details what went well with the project and why, so that other project managers may capitalize on these actions. Project managers may also use this document to determine who the project team members were in order to solicit feedback for planning their projects in the future. This document will be formally communicated with the organization and will become a part of the organizational assets and archives.

  16. The Potential of Computer-Assisted Direct Observation Apps

    Directory of Open Access Journals (Sweden)

    Daniel Wessel

    2015-01-01

    Full Text Available Direct behavior observation, i.e., without first creating a video recording, is a challenging, one-shot task. The behavior has to be coded accurately during the situation itself. Mobile devices can assist direct observation, and there already are applications available for these purposes. However, the mobile revolution has led to new developments in devices, infrastructure, and market penetration that have opened up new, yet untapped, possibilities. In this article, expanded activity theory is used to highlight the unused potential of computer assisted direct observation (CADO apps. If this potential is realized, it can provide observation with the same advantages online questionnaires and sites like Mechanical Turk have provided for surveys and Internet experiments.

  17. Combining playware exergaming with a mobile fitness app

    DEFF Research Database (Denmark)

    Giannisakis, Emmanouil; Lund, Henrik Hautop

    2015-01-01

    We propose a novel playware as a merge between exergames and mobile fitness apps to engage the users in physical exercises, not only as competitive play, but also in the form of cooperative play. The concept connects modular interactive tiles with radio communication to Android tablets and smart...... phones, which can connect to the Internet. This allows the players to monitor their playware exergaming performance on the smart device(s). A test was set up over 8 days allowing two school classes to compete with each other on which class was going to collect the most points playing on the modular tiles...... during the test. The test subjects were from 6th and 7th grade (12-13 years old children). As a social playware, we investigated how the playware mediated cooperative and competitive play amongst the users. It was found that the majority of game play involved social interaction between players...

  18. A Kind of Multifunctional Safety Business Card APP%一种多功能安全名片APP

    Institute of Scientific and Technical Information of China (English)

    郑荣茂; 杨金艳

    2016-01-01

    名片在商务交往或社交活动中经常使用。传统纸质名片存在信息容量低、信息更新后名片即作废、多为一次性用品易造成资源浪费等问题;电子名片存在操作不便、使用过程存在安全隐患等问题。文中针对智能手机强大的运算和灵活的数字通讯功能设计一种多功能安全名片APP,开发Android系统下的APP应用程序。安全名片APP具有信息内容丰富,支持多媒体功能;有多种信息交换功能,信息传递及使用过程中具有安全、便捷、高效等优点有很好的应用和推广价值。%Business cards are frequently used in business communication or social activities. The traditional paper-based business card has many problems, such as the information capacity is low, the business card will be deleted after the renewal of information, the disposable products is easy to cause waste of resources and so on. The electronic business cards have the problems such as the inconvenient operation, the hidden danger in use procedure and so on. This paper designs a kind of multifunctional security card APP, which is based on the functions of powerful computing and flexible digital communication of the intelligent mobile phone, to develop the APP application under the Android system. The security card APP has rich information content, which supports the multimedia function, and has the exchange function of many kinds of information. It is safe, convenient, and high efficiency in the use process and has very good application and promotion value.

  19. Usability Pitfalls of Diabetes mHealth Apps for the Elderly

    Directory of Open Access Journals (Sweden)

    Maša Isaković

    2016-01-01

    Full Text Available Diabetes mellitus has high prevalence in the ageing population and is often accompanied by other comorbidities, such as Alzheimer’s disease, and general disabilities, such as poor eyesight. These comorbidities have redefined ways in which patients use mHealth apps, including diabetes apps. The latter have proven benefits for monitoring blood glucose levels and insulin tracking in the general population. In this paper, we analyse a diabetes monitoring app DeStress Assistant (DeSA, which was developed as a part of an EU project and tested in a hospital setting. Due to the increasing number of older adults, we wanted to ensure the app was suitable for that demographic. Based on a number of supervised tests, we show that the app, which was developed with the help of workshops and feedback from tech-savvy patients and clinicians, is difficult to use by elderly users. We demonstrate that with a small number of changes it is possible to raise the usability of the app in a number of categories. We summarise the lessons learned in the discussion. Our findings demonstrate that special care needs to be taken when developing mHealth apps for the elderly population.

  20. 小众APP生存之道%Survive Road of Small Minority APP

    Institute of Scientific and Technical Information of China (English)

    刘珩

    2015-01-01

    With the rapid development of mobile Internet and the popularity of smart phones, rapid growth in the number of mobile APP. With respect to the mass-APP, “pain point” APP Some minority groups are frequent touch to APP market. However, during the development of small industries in the APP minority, there are still some problems can’t be ignored. By including a small minority of cases of APP, analysis, comparison obtained reasonable suggestions for the future development of niche APP pointed out the direction.%随着移动互联网的快速发展和智能手机的普及,移动APP数量在快速增长。相对于大众型APP,一些触及小众群体“痛点”的APP频现于APP市场。然而,在小众APP行业发展的过程中,也存在一些不容忽视的问题。通过列举小众APP的案例,分析、比较得出了合理的建议,为未来小众APP的发展指明了方向。

  1. A mobile app for delivering in-field soil data for precision agriculture

    Science.gov (United States)

    Isaacs, John P.; Stojanovic, Vladeta; Falconer, Ruth E.

    2015-04-01

    In the last decade precision agriculture has grown from a concept to an emerging technology, largely due to the maturing of GPS and mobile mapping. We investigated methods for reliable delivery and display of appropriate and context aware in-field farm data on mobile devices by developing a prototype android mobile app. The 3D app was developed using OpenGL ES 2.0 and written in Java, using the Android Development Tools (ADT) SDK. The app is able to obtain GPS coordinates and automatically synchronise the view and load relevant data based on the user's location. The intended audience of the mobile app is farmers and agronomists. Apps are becoming an essential tool in an agricultural professional's arsenal however most existing apps are limited to 2D display of data even though the modern chips in mobile devices can support the display of 3D graphics at interactive rates using technologies such as webGL. This project investigated the use of games techniques in the delivery and 3D display of field data, recognising that this may be a departure from the way the field data is currently delivered and displayed to farmers and agronomists. Different interactive 3D visualisation methods presenting spatial and temporal variation in yield values were developed and tested. It is expected that this app can be used by farmers and agronomists to support decision making in the field of precision agriculture and this is a growing market in UK and Europe.

  2. SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation.

    Science.gov (United States)

    Feng, Tuancheng; Niu, Mengmeng; Ji, Chengxiang; Gao, Yuehong; Wen, Jing; Bu, Guojun; Xu, Huaxi; Zhang, Yun-Wu

    2016-08-01

    Amyloid-β (Aβ) peptide plays an essential role in the pathogenesis of Alzheimer's disease (AD) and is generated from amyloid-β precursor protein (APP) through sequential proteolytic cleavages by β-site APP cleaving enzyme 1 (BACE1) and γ-secretase. Trafficking dysregulation of APP, BACE1, and γ-secretase may affect Aβ generation and disease pathogenesis. Sorting nexin 15 (SNX15) is known to regulate protein trafficking. Here, we report that SNX15 is abundantly expressed in mouse neurons and astrocytes. In addition, we show that although not affecting the protein levels of APP, BACE1, and γ-secretase components and the activity of BACE1 and γ-secretase, overexpression and downregulation of SNX15 reduce and promote Aβ production, respectively. Furthermore, we find that overexpression of SNX15 increases APP protein levels in cell surface through accelerating APP recycling, whereas downregulation of SNX15 has an opposite effect. Finally, we show that exogenous expression of human SNX15 in the hippocampal dentate gyrus by adeno-associated virus (AAV) infection can significantly reduce Aβ pathology in the hippocampus and improve short-term working memory in the APPswe/PSEN1dE9 double transgenic AD model mice. Together, our results suggest that SNX15 regulates the recycling of APP to cell surface and, thus, its processing for Aβ generation. PMID:26115702

  3. Personalised mobile health and fitness apps: lessons learned from myFitnessCompanion®.

    Science.gov (United States)

    Gay, Valerie; Leijdekkers, Peter

    2012-01-01

    Smartphones and tablets are slowly but steadily changing the way we look after our health and fitness. Today, many high quality mobile apps are available for users and health professionals and cover the whole health care chain, i.e. information collection, prevention, diagnosis, treatment and monitoring. Our team has developed a mobile health and fitness app called myFitnessCompanion® which has been available via Android market since February 2011. The objective of this paper is to share our experience with rolling out a mobile health and fitness app. We discuss the acceptance of health apps by end-users and healthcare industry. We discuss how mobile health apps will be distributed in the near future, the use of Personal Health Record (PHR) systems such as Microsoft HealthVault and the impact of regulations (FDA) on the future of mobile health apps. The paper is based on seven years of experience by the authors as mobile health and fitness application developers and we discuss the challenges and opportunities for app developers in the health industry.

  4. Tell me your apps and I will tell you your mood: Correlation of apps usage with Bipolar Disorder State

    DEFF Research Database (Denmark)

    Alvarez-Lozano, Jorge; Frost, Mads; Osmani, Venet;

    2014-01-01

    Bipolar Disorder is a disease that is manifested with cycling periods of polar episodes, namely mania and depression. Depressive episodes are manifested through disturbed mood, psychomotor retardation, behaviour change, decrease in energy levels and length of sleep. Manic episodes are manifested...... through elevated mood, psychomotor acceleration and increase in intensity of social interactions. In this paper we report results of a clinical trial with bipolar patients that amongst other aspects, investigated whether changes in general behaviour of patients due to onset of a bipolar episode, can...... behaviour before the psychiatric evaluation and after the psychiatric evaluation. The results show that patients have strong correlation of patterns of app usage with different aspects of their self-reported state including mood, sleep and irritability. While, on the other hand, the patients’ application...

  5. Effect of growth conditions on expression of the acid phosphatase (cyx-appA) operon and the appY gene, which encodes a transcriptional activator of Escherichia coli

    DEFF Research Database (Denmark)

    Brøndsted, Lone; Atlung, Tove

    1996-01-01

    The expression and transcriptional regulation of the Escherichia coli cyx-appA operon and the appY gene has been investigated during different environmental conditions using single copy transcriptional lacZ fusions. The cyx-appA operon encodes acid phosphatase and a putative cytochrome oxidase.......ArcA and AppY activated transcription of the cyx-appA operon during entry into stationary phase and under anaerobic growth conditions. The expression of the cyx-appA operon was affected by the anaerobic energy metabolism.The presence of the electron acceptors nitrate and fumarate repressed the expression...... of the cyx-appA operon. The nitrate repression was partially dependent on NarL. A high expression of the operon was obtained in glucose medium supplemented with formate, where E.coli obtains energy by fermentation. The formate induction was independent of the fhlA gene product. The results presented...

  6. Attitudes and Behaviours to Antimicrobial Prescribing following Introduction of a Smartphone App

    Science.gov (United States)

    Panesar, Preet; Jones, Alisdair; Aldous, Alicia; Kranzer, Katharina; Halpin, Eamus; Fifer, Helen; Macrae, Bruce; Curtis, Carmel

    2016-01-01

    Objectives Our hospital replaced the format for delivering portable antimicrobial prescribing guidance from a paper-based pocket guide to a smartphone application (app). We used this opportunity to assess the relationship between its use and the attitudes and behaviours of antimicrobial prescribers. Methods We used 2 structured cross-sectional questionnaires issued just prior to and 3 months following the launch of the smartphone app. Ordinal Likert scale responses to both frequencies of use and agreement statements permitted quantitative assessment of the relationship between variables. Results The smartphone app was used more frequently than the pocket guide it replaced (p < 0.01), and its increased use was associated with sentiments that the app was useful, easy to navigate and its content relevant. Users who used the app more frequently were more likely to agree that the app encouraged them to challenge inappropriate prescribing by their colleagues (p = 0.001) and were more aware of the importance of antimicrobial stewardship (p = 0.005). Reduced use of the app was associated with agreement that senior physicians’ preferences for antimicrobial prescribing would irrespectively overrule guideline recommendations (p = 0.0002). Conclusions Smartphone apps are an effective and acceptable format to deliver guidance on antimicrobial prescribing. Our findings suggest that they may empower users to challenge incorrect prescribing, breaking well-established behaviours, and thus supporting vital stewardship efforts in an era of increased antimicrobial resistance. Future work will need to focus on the direct impact on drug prescriptions as well as identifying barriers to implementing smartphone apps in other clinical settings. PMID:27111775

  7. Independent relationship between amyloid precursor protein (APP dimerization and γ-secretase processivity.

    Directory of Open Access Journals (Sweden)

    Joo In Jung

    Full Text Available Altered production of β-amyloid (Aβ from the amyloid precursor protein (APP is closely associated with Alzheimer's disease (AD. APP has a number of homo- and hetero-dimerizing domains, and studies have suggested that dimerization of β-secretase derived APP carboxyl terminal fragment (CTFβ, C99 impairs processive cleavage by γ-secretase increasing production of long Aβs (e.g., Aβ1-42, 43. Other studies report that APP CTFβ dimers are not γ-secretase substrates. We revisited this issue due to observations made with an artificial APP mutant referred to as 3xK-APP, which contains three lysine residues at the border of the APP ectodomain and transmembrane domain (TMD. This mutant, which dramatically increases production of long Aβ, was found to form SDS-stable APP dimers, once again suggesting a mechanistic link between dimerization and increased production of long Aβ. To further evaluate how multimerization of substrate affects both initial γ-secretase cleavage and subsequent processivity, we generated recombinant wild type- (WT and 3xK-C100 substrates, isolated monomeric, dimeric and trimeric forms of these proteins, and evaluated both ε-cleavage site utilization and Aβ production. These show that multimerization significantly impedes γ-secretase cleavage, irrespective of substrate sequence. Further, the monomeric form of the 3xK-C100 mutant increased long Aβ production without altering the initial ε-cleavage utilization. These data confirm and extend previous studies showing that dimeric substrates are not efficient γ-secretase substrates, and demonstrate that primary sequence determinants within APP substrate alter γ-secretase processivity.

  8. Experimental Analysis of Popular Smartphone Apps Offering Anonymity, Ephemerality, and End-to-End Encryption

    OpenAIRE

    Onwuzurike, Lucky; De Cristofaro, Emiliano

    2015-01-01

    As social networking takes to the mobile world, smartphone apps provide users with ever-changing ways to interact with each other. Over the past couple of years, an increasing number of apps have entered the market offering end-to-end encryption, self-destructing messages, or some degree of anonymity. However, little work thus far has examined the properties they offer. To this end, this paper presents a taxonomy of 18 of these apps: we first look at the features they promise in their appeal ...

  9. There's an App for That: A Guide for Healthcare Practitioners and Researchers on Smartphone Technology.

    Science.gov (United States)

    Trevena, Lyndal

    2015-01-01

    Smartphone technology is nascent compared to other technologies; however, it has shown an unprecedented uptake amongst lay consumers and professionals. This article presents the history, components, and key features of smartphones, as well as their related concepts and how they work, and it also delineates the process of smartphone applications (apps) development and publishing in the app stores. It also describes and discusses smartphone technology utilisation for health consumers, healthcare professionals, and health researchers, as well as the regulations of health-related apps.

  10. Efficacy of three-dimensional visualization in mobile apps for patient education regarding orthognathic surgery.

    Science.gov (United States)

    Pulijala, Y; Ma, M; Ju, X; Benington, P; Ayoub, A

    2016-09-01

    'Sur-face' is an interactive mobile app illustrating different orthognathic surgeries and their potential complications. This study aimed to evaluate the efficacy of Sur-face by comparing two methods of delivering patient information on orthognathic surgeries and their related potential complications: a mobile app with interactive three-dimensional (3D) animations and a voice recording containing verbal instructions only. For each method, the participants' acquired knowledge was assessed using a custom-designed questionnaire. Participants in the 'app' group performed significantly better (Papps. PMID:27157633

  11. The Bluetooth Based LED Control For Arduino Test Platform By Using Mobile APP

    Directory of Open Access Journals (Sweden)

    Yi-Jen Mon

    2015-06-01

    Full Text Available Abstract The Bluetooth is a commonly known convenient and famous communication protocol. In this paper it is used to control LED mounted on Arduino test platform by using the APP of mobile phone. At first the control program is completed by Arduino development software environment then the Android APP is installed in mobile phone. Finally by using the Bluetooth of mobile phone the test platform will be connected. The LED can be controlled by APP of mobile phone. The experiment results are demonstrated the effective performance.

  12. Laparoscopic Transhiatal Anterograde Inversion Esophagectomy for Upper Esophagus Cancer:Case Report%腹腔镜下经食管裂孔顺行食管拔脱术治疗上段食管癌1例

    Institute of Scientific and Technical Information of China (English)

    张卫强; 刘克强; 裴迎新; 赵京

    2015-01-01

    本文报道1例腹腔镜下顺行食管内翻拔脱术治疗食管癌。患者女,72岁,吞咽不畅1个月,经胃镜和活检病理诊断为上胸段食管鳞状细胞癌。术前分期T1N0M0。2014年12月31日行腹腔镜下顺行食管内翻拔脱术。腹腔镜下用超声刀游离胃、膈食管裂孔和下胸段食管,左颈部切口顺行拔脱食管,经上腹部切口制做管状胃,将管状胃牵至颈部与食管残端吻合。手术过程顺利,手术时间200 min,术中出血量150 ml。术后恢复顺利,第9天进清流食,无呕吐,无反酸,第12天出院。住院期间未发生吻合口漏、声音嘶哑等并发症。术后病理食管鳞癌,淋巴结无转移。术后3个月复诊,进食可,无呕吐,胃酸反流2~3次/d。%[Summary] On December 31 of 2014, laparoscopic transhiatal anterograde inversion esophagectomy was performed in a 72-year-old female patient for upper thoracic esophageal cancer.The indications and eligibility for this surgery were evaluated.The patient presented with a one-month history of progressive dysphagia.Gastroscopy and pathology revealed upper thoracic esophageal squamous cell carcinoma.Chest CT scanning and endoscopic ultrasonography suggested the clinical stage of T1N0M0.Laparoscopic transhiatal anterograde inversion esophagectomy was given.The lesser and greater curvature and the distal third of esophagus were mobilized. Meanwhile, the cervical esophagus was mobilized and the cervical lymph nodes were dissected.The laparoscopic transhiatal anterograde esophagectomy was performed and linear staplers were used to create a gastric tube.The gastric tube was retracted to the neck.The esophagogastric anastomosis was performed.The operation time was 200 min and the intraoperative blood loss was about 150 ml.The patient was allowed to have liquid diet from the 9th post-operative day.The length of postoperative hospital stay was 12 days.No emptying dysfunction and hoarseness occurred

  13. Binding-Induced Fluorescence of Serotonin Transporter Ligands

    DEFF Research Database (Denmark)

    Wilson, James; Ladefoged, Lucy Kate; Babinchak, Michael;

    2014-01-01

    The binding-induced fluorescence of 4-(4-(dimethylamino)-phenyl)-1-methylpyridinium (APP(+)) and two new serotonin transporter (SERT)-binding fluorescent analogues, 1-butyl-4-[4-(1-dimethylamino)phenyl]-pyridinium bromide (BPP(+)) and 1-methyl-4-[4-(1-piperidinyl)phenyl]-pyridinium (PPP(+)), has ...

  14. Assessing Self-Control and Geosocial Networking App Behavior Among an Online Sample of Men Who Have Sex with Men.

    Science.gov (United States)

    Beymer, Matthew R; Rossi, Aimee Drolet; Shu, Suzanne B

    2016-08-01

    Geosocial networking phone applications (GSN apps) used to meet sexual partners have become popular in the men who have sex with men (MSM) communities of the USA since 2009. Previous studies have shown greater incidence of gonorrhea and chlamydia and lower testing frequency for HIV testing among GSN app users when compared to non-users. The present study aims to determine the type, number, and frequency of apps used, as well as the association between dispositional self-control and health-related behaviors. Participants (n = 146) were recruited from Amazon's Mechanical Turk program to respond to a brief GSN app marketing survey. Multivariate regression was used to determine differences in app priorities, length of app use, and number of sexual partners between high self-control and low self-control participants. A majority of the participants reported using Grindr (78 %) followed by Scruff (19 %), Growlr (12 %), and Jack'd (12 %). Most individuals used one app only (58 %), but a significant proportion reported using two apps (28 %) or three or more apps (14 %). Respondents with low self-control were more likely to report a higher number of hours using GSN apps and a higher number of sexual partners, controlling for race/ethnicity, education, employment, and HIV status. Given the popularity of this burgeoning communication medium, these findings have important implications for developing prevention resources for different segments of GSN app users.

  15. Assessing Self-Control and Geosocial Networking App Behavior Among an Online Sample of Men Who Have Sex with Men.

    Science.gov (United States)

    Beymer, Matthew R; Rossi, Aimee Drolet; Shu, Suzanne B

    2016-08-01

    Geosocial networking phone applications (GSN apps) used to meet sexual partners have become popular in the men who have sex with men (MSM) communities of the USA since 2009. Previous studies have shown greater incidence of gonorrhea and chlamydia and lower testing frequency for HIV testing among GSN app users when compared to non-users. The present study aims to determine the type, number, and frequency of apps used, as well as the association between dispositional self-control and health-related behaviors. Participants (n = 146) were recruited from Amazon's Mechanical Turk program to respond to a brief GSN app marketing survey. Multivariate regression was used to determine differences in app priorities, length of app use, and number of sexual partners between high self-control and low self-control participants. A majority of the participants reported using Grindr (78 %) followed by Scruff (19 %), Growlr (12 %), and Jack'd (12 %). Most individuals used one app only (58 %), but a significant proportion reported using two apps (28 %) or three or more apps (14 %). Respondents with low self-control were more likely to report a higher number of hours using GSN apps and a higher number of sexual partners, controlling for race/ethnicity, education, employment, and HIV status. Given the popularity of this burgeoning communication medium, these findings have important implications for developing prevention resources for different segments of GSN app users. PMID:27184573

  16. APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses.

    Science.gov (United States)

    Fanutza, Tomas; Del Prete, Dolores; Ford, Michael J; Castillo, Pablo E; D'Adamio, Luciano

    2015-11-09

    The amyloid precursor protein (APP), whose mutations cause familial Alzheimer's disease, interacts with the synaptic release machinery, suggesting a role in neurotransmission. Here we mapped this interaction to the NH2-terminal region of the APP intracellular domain. A peptide encompassing this binding domain -named JCasp- is naturally produced by a γ-secretase/caspase double-cut of APP. JCasp interferes with the APP-presynaptic proteins interaction and, if linked to a cell-penetrating peptide, reduces glutamate release in acute hippocampal slices from wild-type but not APP deficient mice, indicating that JCasp inhibits APP function.The APP-like protein-2 (APLP2) also binds the synaptic release machinery. Deletion of APP and APLP2 produces synaptic deficits similar to those caused by JCasp. Our data support the notion that APP and APLP2 facilitate transmitter release, likely through the interaction with the neurotransmitter release machinery. Given the link of APP to Alzheimer's disease, alterations of this synaptic role of APP could contribute to dementia.

  17. A Survey on the Willingness to Use Physical Activity Smartphone Applications (Apps) in Patients with Chronic Diseases.

    Science.gov (United States)

    Sun, Liu; Jiao, Chen; Wang, Yanling; Xiao, Qian; Zhang, Yiling; Wu, Ying

    2016-01-01

    This study aimed to explore the willingness of using physical activity smartphone apps among patients with chronic diseases. 218 outpatients from a tertiary hospital in Beijing were involved using a questionnaire. Over half of the patients (53.7%) were willing to use smartphone apps to promote physical activities. The individuals more likely to use physical activity apps tended to be younger (≤44 years), be more educated, perceiving their disease need exercise instruction or professional support, current smartphone user, having previous experience of using physical activity apps, and accepting paid apps (P<0.05). The results could help health educator suggest chronic disease patients to use apps to do more exercises. Further research could be focus on evaluate the effects of using physical activity apps in chronic disease patients. PMID:27332468

  18. 76 FR 31673 - ITS Joint Program Office; Intelligent Transportation Systems Program Advisory Committee; Notice...

    Science.gov (United States)

    2011-06-01

    ... ITS Joint Program Office; Intelligent Transportation Systems Program Advisory Committee; Notice of... (FACA) (Pub. L. 72-363; 5 U.S.C. app.), a meeting of the Intelligent Transportation Systems (ITS) Program Advisory Committee (ITS PAC). The meeting will be held on June 17, 2011, from 8 a.m. to 4 p.m....

  19. 75 FR 54002 - Commercial Space Transportation Advisory Committee-Open Meeting

    Science.gov (United States)

    2010-09-02

    ... Federal Aviation Administration Commercial Space Transportation Advisory Committee--Open Meeting AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory.... 92-463, 5 U.S.C. App. 2), notice is hereby given of a meeting of the Commercial Space...

  20. 75 FR 71791 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2010-11-24

    ... Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation... Act (Pub. L. 92-463, 5 U.S.C. App. 2), notice is hereby given of a teleconference of the...

  1. 77 FR 16891 - Commercial Space Transportation Advisory Committee-Open Meeting

    Science.gov (United States)

    2012-03-22

    ... Federal Aviation Administration Commercial Space Transportation Advisory Committee--Open Meeting AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory.... 92-463, 5 U.S.C. App. 2), notice is hereby given of a meeting of the Commercial Space...

  2. 75 FR 52058 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2010-08-24

    ... Federal Aviation Administration Commercial Space Transportation Advisory Committee-Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation... Act (Pub. L. 92-463, 5 U.S.C. App. 2), notice is hereby given of a teleconference of the...

  3. 76 FR 17474 - Commercial Space Transportation Advisory Committee-Open Meeting

    Science.gov (United States)

    2011-03-29

    ... Federal Aviation Administration Commercial Space Transportation Advisory Committee--Open Meeting AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory.... 92-463, 5 U.S.C. App. 2), notice is hereby given of a meeting of the Commercial Space...

  4. 76 FR 67018 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2011-10-28

    ... Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation... Act (Pub. L. 92-463, 5 U.S.C. App. 2), notice is hereby given of a teleconference of the...

  5. 75 FR 16901 - Commercial Space Transportation Advisory Committee-Open Meeting

    Science.gov (United States)

    2010-04-02

    ... Federal Aviation Administration Commercial Space Transportation Advisory Committee--Open Meeting AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory.... 92-463, 5 U.S.C. App. 2), notice is hereby given of the meetings of the Commercial...

  6. 76 FR 15041 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2011-03-18

    ... Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation... Act (Pub. L. 92-463, 5 U.S.C. App. 2), notice is hereby given of a teleconference of the...

  7. 76 FR 4743 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2011-01-26

    ... Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation... Act (Pub. L. 92-463, 5 U.S.C. App. 2), notice is hereby given of a teleconference of the...

  8. 75 FR 38866 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2010-07-06

    ... Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation... Act (Pub. L. 92-463, 5 U.S.C. App. 2), notice is hereby given of a teleconference of the...

  9. 78 FR 69742 - Commercial Space Transportation Advisory Committee-Open Meeting

    Science.gov (United States)

    2013-11-20

    ... Federal Aviation Administration Commercial Space Transportation Advisory Committee--Open Meeting AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory.... 92-463, 5 U.S.C. App. 2), notice is hereby given of a meeting of the Commercial Space...

  10. 75 FR 51332 - Commercial Space Transportation Advisory Committee-Public Teleconference

    Science.gov (United States)

    2010-08-19

    ... Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation... Act (Pub. L. 92-463, 5 U.S.C. App. 2), notice is hereby given of a teleconference of the...

  11. A Pilot Test of a Mobile App for Drug Court Participants.

    Science.gov (United States)

    Johnson, Kimberly; Richards, Stephanie; Chih, Ming-Yuan; Moon, Tae Joon; Curtis, Hilary; Gustafson, David H

    2016-01-01

    The U.S. criminal justice system refers more people to substance abuse treatment than any other system. Low treatment completion rates and high relapse rates among addicted offenders highlight the need for better substance use disorder treatment and recovery tools. Mobile health applications (apps) may fill that need by providing continuous support. In this pilot test, 30 participants in a Massachusetts drug court program used A-CHESS, a mobile app for recovery support and relapse prevention, over a four-month period. Over the course of the study period, participants opened A-CHESS on average of 62% of the days that they had the app. Social networking tools were the most utilized services. The study results suggest that drug court participants will make regular use of a recovery support app. This pilot study sought to find out if addicted offenders in a drug court program would use a mobile application to support and manage their recovery. PMID:26917964

  12. Comparision and analysis of top 10 exercise android Apps in mainland China.

    Science.gov (United States)

    Wang, Yanling; Sun, Liu; Xu, Yahong; Xiao, Qian; Chang, Polun; Wu, Ying

    2015-01-01

    Medical guidelines highly recommend physical activity and aerobic exercise in the prevention of primary and secondary cardiovascular disease. The use of exercise-promoting application software may improve clinical outcomes for cardiovascular disease (CVD) patients. The study aimed to compare and analyze the functions of the top 10 exercise Android Apps which had more than 1,000,000 downloads from the main four Android App stores in mainland China. The results showed that most of these popular apps had pedometer, exercise plan preset, user data presentation, user encouragement and community sharing functions while a few of them had exercise video clips or animation support and wearable devices. Given these data, the conclusion is that these popular apps fulfill some of the functions recommended by medical guidelines, however, lack of some functions such as pre-exercise risk assessment, the exercise intensity recording, specific instructions by professionals, and monitoring functions for CVD patients.

  13. Efficacy of three-dimensional visualization in mobile apps for patient education regarding orthognathic surgery.

    Science.gov (United States)

    Pulijala, Y; Ma, M; Ju, X; Benington, P; Ayoub, A

    2016-09-01

    'Sur-face' is an interactive mobile app illustrating different orthognathic surgeries and their potential complications. This study aimed to evaluate the efficacy of Sur-face by comparing two methods of delivering patient information on orthognathic surgeries and their related potential complications: a mobile app with interactive three-dimensional (3D) animations and a voice recording containing verbal instructions only. For each method, the participants' acquired knowledge was assessed using a custom-designed questionnaire. Participants in the 'app' group performed significantly better (Porthognathic surgical procedure and its associated complications. This study emphasizes the impact of 3D visualizations in delivering information regarding orthognathic surgery and highlights the advantage of delivering validated patient information through mobile apps.

  14. Reactive oxidative species enhance amyloid toxicity in APP/PS1 mouse neurons

    Institute of Scientific and Technical Information of China (English)

    Bin Yang; Xiaqin Sun; Hilal Lashuel; Yan Zhang

    2012-01-01

    [Objective] To investigate whether intracellular amyloid β (iAβ) induces toxicity in wild type (WT) and APP/PS1 mice,a mouse model of Alzheimer's disease.[Methods] Different forms of Aβ aggregates were microinjected into cultured WT or APP/PS1 mouse hippocampal neurons.TUNEL staining was performed to examine neuronal cell death.Reactive oxidative species (ROS) were measured by MitoSOXTM Red mitochondrial superoxide indicator.[Results]Crude,monomer and protofibril Aβ induced more toxicity in APP/PS1 neurons than in WT neurons.ROS are involved in mediating the vulnerability of APP/PS1 neurons to iAβ toxicity.[[Conclusion

  15. The eDL mobile app - Improving communication between hospitals, patients and community physicians

    NARCIS (Netherlands)

    Lezcano, Leonardo; Drachsler, Hendrik; Ternier, Stefaan; Kalz, Marco; Specht, Marcus

    2013-01-01

    Lezcano, L., Drachsler, H., Ternier, S., Kalz, M., & Specht, M. (2012, October). The eDL mobile app - Improving communication between hospitals, patients and community physicians. Presentation at the kickoff meeting of the Patient project, Heerlen, The Netherlands.

  16. Development of an accommodative smartphone app for medical guidelines in pediatric emergencies.

    Science.gov (United States)

    Schmucker, Michael; Heid, Jörn; Haag, Martin

    2014-01-01

    One of the outcomes of a training concept for physicians and nurses concerning pediatric emergencies at the Heidelberg University Hospital was that the work and procedures in childhood emergencies could be simplified by replacing the existing paper-based guidelines with a smartphone app. Since the project funds for this were already used up, a group of students from the master program "Medical Informatics" of Heidelberg and Heilbronn Universities took over the development of the app. Particular attention was given to the need for compatibility with the variety of devices (device size and screen resolution) and platform independence. The guidelines themselves were scripted in HTML5, JavaScript and CSS (responsive web design); managed by a container programmed in Sencha Touch. Even though the app is not yet available in the App-Store due to the limited timeframe, the students gained a great deal of valuable experience in developing platform independent software for mobile devices. PMID:24825689

  17. NOAA Climate Data Record (CDR) of AVHRR Polar Pathfinder Extended (APP-X) Cryosphere

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Climate Data Record (CDR) of the extended AVHRR Polar Pathfinder (APP-x) cryosphere contains 19 geophysical variables over the Arctic and Antarctic for the...

  18. Usabilty Evaluation of a Prototype Mobile App for Health Management for Persons Living with HIV.

    Science.gov (United States)

    Schnall, Rebecca; Bakken, Suzanne; Brown Iii, William; Carballo-Dieguez, Alex; Iribarren, Sarah

    2016-01-01

    Mobile health (mHealth) applications (apps) have the potential to support self-management and improve health outcomes in persons living with HIV (PLWH). In this paper, we report on the final step in a three-stage user-centered design process for the development of a mHealth app for PLWH. We conducted a usability evaluation with 10 targeted end-users and a heuristic evaluation with 5 persons with informatics expertise to assess the usability of a prototype mHealth app for PLWH to manage their health. At the end of our usability evaluation, we finalized a Design Document that included the user interface design and functional specifications of the mHealth app. The functional areas which were identified at the end of our iterative process included: Communication, Reminders, Medication Logs, Lab Reports, Pharmacy Info, Nutrition and Fitness, Resources and Settings. PMID:27332247

  19. LabNotes: A Mobile App for Instrument Control and Data Collection Project

    Data.gov (United States)

    National Aeronautics and Space Administration — LabNotes is an IPad/IPod software application (app) and low-cost USB connector harness that can be used to operate and collect data from scientific instruments.

  20. E 社区 APP 设计与开发:体验智能现代社区生活%The APP Design and Development of E Community--Intelligent Modern Community Life Experience

    Institute of Scientific and Technical Information of China (English)

    杨建迪; 黄岚

    2015-01-01

    When the smartphone applications hit among industry, mobile phone APP has entered people's lives every corner. Message clear and concise, convenient interactive way and let the community property APP also ushered in a new growth point. Today, people can never leave home to understand the surrounding commercial information, enjoy the phone APP brings the intelligent way of life. Based on the practical experience in the development community APP process to the function of community type of APP, advantages and disadvantages, and elaborates the development and analysis.%当智能手机应用风靡各个行业时,手机 APP 也随之走进了人们生活的每一个角落。信息传递简洁明了,互动方式灵活方便,让物业社区 APP 也迎来了一个新的增长点。如今,居民可以足不出户了解周边的商业信息,享受手机 APP 带来的智能化生活方式。本文通过在开发社区 APP 过程中的实际经历对社区类 APP 的功能、优缺点及发展状况进行阐述和分析。

  1. Impact of mobile app user acquisition on managerial decisions: Evidence from empirical experiment

    OpenAIRE

    Cabral, Francisco Manuel da Silva Brás Gaspar Vieira

    2015-01-01

    In this research we conducted a mixed research, using qualitative and quantitative analysis to study the relationship and impact between mobile advertisement and mobile app user acquisition and the conclusions companies can derive from it. Data was gathered from management of mobile advertisement campaigns of a portfolio of three different mobile apps. We found that a number of implications can be extracted from this intersection, namely to product development, internationalisa...

  2. Apps to promote physical activity among adults: a review and content analysis

    OpenAIRE

    Middelweerd, Anouk; Mollee, Julia S; van der Wal, C Natalie; Brug, Johannes; te Velde, Saskia J

    2014-01-01

    Background In May 2013, the iTunes and Google Play stores contained 23,490 and 17,756 smartphone applications (apps) categorized as Health and Fitness, respectively. The quality of these apps, in terms of applying established health behavior change techniques, remains unclear. Methods The study sample was identified through systematic searches in iTunes and Google Play. Search terms were based on Boolean logic and included AND combinations for physical activity, healthy lifestyle, exercise, f...

  3. Dexteroid: Detecting Malicious Behaviors in Android Apps Using Reverse-Engineered Life Cycle Models

    OpenAIRE

    Junaid, Mohsin; Liu, Donggang; Kung, David

    2015-01-01

    The amount of Android malware has increased greatly during the last few years. Static analysis is widely used in detecting such malware by analyzing the code without execution. The effectiveness of current tools relies on the app model as well as the malware detection algorithm which analyzes the app model. If the model and/or the algorithm is inadequate, then sophisticated attacks that are triggered by specific sequences of events will not be detected. This paper presents a static analysis f...

  4. Using a Mobile App to Promote Smoking Cessation in Hospitalized Patients

    OpenAIRE

    Finkelstein, Joseph; Cha, Eun Me

    2016-01-01

    Background The potential of interactive health education for preventive health applications has been widely demonstrated. However, use of mobile apps to promote smoking cessation in hospitalized patients has not been systematically assessed. Objective This study was conducted to assess the feasibility of using a mobile app for the hazards of smoking education delivered via touch screen tablets to hospitalized smokers. Methods Fifty-five consecutive hospitalized smokers were recruited. Patient...

  5. Ny app kan være guld værd for psykisk syge

    DEFF Research Database (Denmark)

    Frost, Mads; Bardram, Jakob Eyvind

    2012-01-01

    Et forskningssamarbejde mellem IT-Universitetet i København og Region Hovedstadens Psykiatri har resulteret i en app til Smartphones, som kan blive et effektivt værktøj i behandlingen af patienter med bipolar lidelse.......Et forskningssamarbejde mellem IT-Universitetet i København og Region Hovedstadens Psykiatri har resulteret i en app til Smartphones, som kan blive et effektivt værktøj i behandlingen af patienter med bipolar lidelse....

  6. Tethys: A Platform for Water Resources Modeling and Decision Support Apps

    Science.gov (United States)

    Nelson, J.; Swain, N. R.

    2015-12-01

    The interactive nature of web applications or "web apps" makes it an excellent medium for conveying complex scientific concepts to lay audiences and creating decision support tools that harness cutting edge modeling techniques. However, the technical expertise required to develop web apps represents a barrier for would-be developers. This barrier can be characterized by the following hurdles that developers must overcome: (1) identify, select, and install software that meet the spatial and computational capabilities commonly required for water resources modeling; (2) orchestrate the use of multiple free and open source (FOSS) projects and navigate their differing application programming interfaces; (3) learn the multi-language programming skills required for modern web development; and (4) develop a web-secure and fully featured web portal to host the app. Tethys Platform has been developed to lower the technical barrier and minimize the initial development investment that prohibits many scientists and engineers from making use of the web app medium. It includes (1) a suite of FOSS that address the unique data and computational needs common to water resources web app development, (2) a Python software development kit that streamlines development, and (3) a customizable web portal that is used to deploy the completed web apps. Tethys synthesizes several software projects including PostGIS, 52°North WPS, GeoServer, Google Maps™, OpenLayers, and Highcharts. It has been used to develop a broad array of web apps for water resources modeling and decision support for several projects including CI-WATER, HydroShare, and the National Flood Interoperability Experiment. The presentation will include live demos of some of the apps that have been developed using Tethys to demonstrate its capabilities.

  7. What We Know and Do Not Know About Mobile App Usage and Stickiness: A Research Agenda

    OpenAIRE

    Christopher P. Furner; Pradeep Racherla; Jeffrey S. Babb

    2015-01-01

    Mobile applications (apps) have transformed the way firms and consumers communicate with each other, and have now become integral to firms' marketing strategies. However, in a marketplace characterized by myriad choices, one of the biggest challenges that Marketers face is to foster continued and frequent use, or stickiness. This brings forth two important questions: what factors affect consumers' decision to use and “stick†to apps? What are the key outcomes of stickiness for both consume...

  8. A Theory-Based Exercise App to Enhance Exercise Adherence: A Pilot Study

    Science.gov (United States)

    Voth, Elizabeth C; Oelke, Nelly D

    2016-01-01

    Background Use of mobile health (mHealth) technology is on an exponential rise. mHealth apps have the capability to reach a large number of individuals, but until now have lacked the integration of evidence-based theoretical constructs to increase exercise behavior in users. Objective The purpose of this study was to assess the effectiveness of a theory-based, self-monitoring app on exercise and self-monitoring behavior over 8 weeks. Methods A total of 56 adults (mean age 40 years, SD 13) were randomly assigned to either receive the mHealth app (experimental; n=28) or not to receive the app (control; n=28). All participants engaged in an exercise goal-setting session at baseline. Experimental condition participants received weekly short message service (SMS) text messages grounded in social cognitive theory and were encouraged to self-monitor exercise bouts on the app on a daily basis. Exercise behavior, frequency of self-monitoring exercise behavior, self-efficacy to self-monitor, and self-management of exercise behavior were collected at baseline and at postintervention. Results Engagement in exercise bouts was greater in the experimental condition (mean 7.24, SD 3.40) as compared to the control condition (mean 4.74, SD 3.70, P=.03, d=0.70) at week 8 postintervention. Frequency of self-monitoring increased significantly over the 8-week investigation between the experimental and control conditions (Presearch to feasibly integrate theoretical constructs into existing exercise apps. In addition, findings provide preliminary support for theory-based apps to increase self-monitoring and exercise behavior in comparison to a control, no-app condition. PMID:27307134

  9. Your WiFi is leaking: what do your mobile apps gossip about you?

    OpenAIRE

    ATKINSON, J. S.; Rio, M.; Mitchell, J. E.; Matich, G.

    2016-01-01

    This paper describes how mobile device apps can inadvertently broadcast personal information through their use of wireless networks despite the correct use of encryption. Using a selection of personas we illustrate how app usage can be tied to personal information. Users would likely assume the confidentiality of personal information (including age, religion, sexuality and gender) when using an encrypted network. However, we demonstrate how encrypted traffic pattern analysis can allow a remot...

  10. Windows Instant Messaging App Forensics: Facebook and Skype as Case Studies

    OpenAIRE

    Teing Yee Yang; Ali Dehghantanha; Kim-Kwang Raymond Choo; Zaiton Muda

    2016-01-01

    Instant messaging (IM) has changed the way people communicate with each other. However, the interactive and instant nature of these applications (apps) made them an attractive choice for malicious cyber activities such as phishing. The forensic examination of IM apps for modern Windows 8.1 (or later) has been largely unexplored, as the platform is relatively new. In this paper, we seek to determine the data remnants from the use of two popular Windows Store application software for instant me...

  11. Google Apps as an alternative to Microsoft Office in a multinational company: the GAPS project

    OpenAIRE

    Bourquin, Luc; Ceillier, Thierry

    2010-01-01

    A large multinational Company is launching the GAPS Project to assess the suitability of Google Apps as an alternative to the current email, collaboration and office toolset. In order to make a decision, the company needs recommendations based on a complete project assessing the Google Apps offering, taking into account the company’s specificities. The company currently uses Microsoft Office with Exchange. Identified problems include the cost of licenses, their dependency on Microsoft, the co...

  12. Vehicle-to-anything application (v2anything app) for electric vehicles

    OpenAIRE

    João C. Ferreira; Monteiro, Vítor Duarte Fernandes; Afonso, João L.

    2014-01-01

    This paper presents a mobile information system denominated as Vehicle-to-Anything Application (V2Anything App), and explains its conceptual aspects. This application is aimed at giving relevant information to Full Electric Vehicle (FEV) drivers, by supporting the integration of several sources of data in a mobile application, thus contributing to the deployment of the electric mobility process. The V2Anything App provides recommendations to the drivers about the FEV range autonomy, location ...

  13. Comparing applets and oranges: barriers to evidence-based practice for app-based psychological interventions.

    Science.gov (United States)

    Leigh, Simon

    2016-08-01

    Poor-quality pharmaceuticals and medical devices rarely make it to market; however, the same cannot be said for app-based interventions. With a high availability but low evidence base for mHealth, apps are an increasingly uncertain prospect to users and healthcare professionals alike. Although in a first-best situation, the burden of proof concerning app safety, clinical and cost-effectiveness 'should' ultimately lie with app developers; a number of barriers to evidence generation, including the fact that 'acceptable evidence' itself is largely open to interpretation, mean that it may be folly to expect this paucity of real-world effectiveness research to improve. While the health technology assessment of established therapeutic modalities including pharmaceuticals and talking therapies benefits from the existence of approved evaluative guidelines, unfortunately the same cannot be said for app-based interventions, specifically with regard to outcomes measurement. As such, it would seem that in order to prevent the comparative assessment of apps simply becoming an exercise comparing apples and oranges, there is a clear need for consensus and guidance for app developers, as to which patient-reported outcome measures, among the hundreds available, are of clinical use to those making decisions, and should therefore be used when developing app-based interventions. By negating the fear that any evidence collected may be of poor quality, we can reincentivise developers to engage in evidence generation, and in doing so, maximise the likelihood of evidence-based decision-making taking a firm hold. However, only by dispelling the ambiguity around what acceptable evidence can and should look like, can we begin to do so. PMID:27431656

  14. Exploring the Usability of a Mobile App for Adolescent Obesity Management

    OpenAIRE

    O'Malley, Grace; Dowdall, Grainne; Burls, Amanda; Perry, Ivan J; Curran, Noirin

    2014-01-01

    Background Obesity is a global epidemic. Behavioral change approaches towards improving nutrition, increasing physical activity level, improving sleep, and reducing sitting time are recommended as best practices in adolescent obesity management. However, access to evidence-based treatment is limited and portable technologies such as mobile apps may provide a useful platform to deliver such lifestyle interventions. No evidence-based validated app exists for obesity intervention; therefore, a n...

  15. Curcumin improves bone microarchitecture and enhances mineral density in APP/PS1 transgenic mice.

    Science.gov (United States)

    Yang, Mao-Wei; Wang, Tong-Hao; Yan, Pei-Pei; Chu, Li-Wei; Yu, Jiang; Gao, Zhi-Da; Li, Yuan-Zhou; Guo, Bao-Lei

    2011-01-15

    Alzheimer's disease and osteoporosis are often observed to co-occur in clinical practice. The present study aimed to evaluate the bone microarchitecture and bone mineral density (BMD) of the proximal tibia in APP/PS1 transgenic mice by micro-computed tomography (micro-CT), and to search for evidence that curcumin can be used to reduce bone mineral losses and treat osteoporosis after senile dementia in these transgenic mice. Three-month-old female mice were divided into the following groups (n=9 per group): wild-type mice (WT group); APP/PS1 transgenic mice (APP group); and APP/PS1 transgenic mice with curcumin treatment (APP+Cur group). Between 9 and 12 months of age, the APP+Cur group were administered curcumin orally (600ppm). CT scans of the proximal tibia were taken at 6, 9 and 12 months. At 6 months, there were little differences in the structural parameters. At 9 months, the APP groups displayed loss of bone volume ratio (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N) and connectivity density (Conn.D) and increases in trabecular separation (Tb.Sp) and geometric degree of anisotropy (DA) (Pled to constant increases in the trabecular bone mass of the metaphysis and clearly improved the BMD. By the same time, we measured the TNF-α and IL-6 in the serum among the different groups at 6, 9 and 12 months by enzyme-linked immunoassay(ELISA). These results suggest that APP/PS1 transgenic mice are susceptible to osteoporosis, and that curcumin can prevent further deterioration of the bone structure and produce beneficial changes in bone turnover. The change of inflammation cytokine, including TNF-α and IL-6, may play an important role in the mechanisms of action of curcumin, but the detail mechanism remains unknown. PMID:20637579

  16. 那些生产创意的APP

    Institute of Scientific and Technical Information of China (English)

    周鑫磊

    2014-01-01

    刚刚过去的WWDC Apple Design Awards App(ADA)评选拉下帷幕,又有一些来自全球各地的开发者设计的极为出色的App捧得了今年的ADA,获得这个由Apple每年从几十万甚至逐年递增上百万的App中挑选出11款不等的App非常不易。被ADA评选的App并不是我们生活里常见的那些明星产品一样受大众瞩目,反而是一些在个别领域以专业深度见长又不容易上手且并非免费的一些小众产品,而这些产品又最能代表在App Store上设计水准最为突出的一批App,虽然这些App的受益者只体现在一部分人那里,但往往它们的出现代表着你能在iPad或者iPhone、iPod Touch这样的后PC时代产品下能做出什么惊人之举。

  17. The YeastGenome app: the Saccharomyces Genome Database at your fingertips.

    Science.gov (United States)

    Wong, Edith D; Karra, Kalpana; Hitz, Benjamin C; Hong, Eurie L; Cherry, J Michael

    2013-01-01

    The Saccharomyces Genome Database (SGD) is a scientific database that provides researchers with high-quality curated data about the genes and gene products of Saccharomyces cerevisiae. To provide instant and easy access to this information on mobile devices, we have developed YeastGenome, a native application for the Apple iPhone and iPad. YeastGenome can be used to quickly find basic information about S. cerevisiae genes and chromosomal features regardless of internet connectivity. With or without network access, you can view basic information and Gene Ontology annotations about a gene of interest by searching gene names and gene descriptions or by browsing the database within the app to find the gene of interest. With internet access, the app provides more detailed information about the gene, including mutant phenotypes, references and protein and genetic interactions, as well as provides hyperlinks to retrieve detailed information by showing SGD pages and views of the genome browser. SGD provides online help describing basic ways to navigate the mobile version of SGD, highlights key features and answers frequently asked questions related to the app. The app is available from iTunes (http://itunes.com/apps/yeastgenome). The YeastGenome app is provided freely as a service to our community, as part of SGD's mission to provide free and open access to all its data and annotations. PMID:23396302

  18. The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization

    Energy Technology Data Exchange (ETDEWEB)

    S Lee; Y Xue; J Hulbert; Y Wang; X Liu; B Demeler; Y Ha

    2011-12-31

    Amyloid precursor protein (APP) is genetically linked to Alzheimer's disease. APP is a type I membrane protein, and its oligomeric structure is potentially important because this property may play a role in its function or affect the processing of the precursor by the secretases to generate amyloid {beta}-peptide. Several independent studies have shown that APP can form dimers in the cell, but how it dimerizes remains controversial. At least three regions of the precursor, including a centrally located and conserved domain called E2, have been proposed to contribute to dimerization. Here we report two new crystal structures of E2, one from APP and the other from APLP1, a mammalian APP homologue. Comparison with an earlier APP structure, which was determined in a different space group, shows that the E2 domains share a conserved and antiparallel mode of dimerization. Biophysical measurements in solution show that heparin binding induces E2 dimerization. The 2.1 {angstrom} resolution electron density map also reveals phosphate ions that are bound to the protein surface. Mutational analysis shows that protein residues interacting with the phosphate ions are also involved in heparin binding. The locations of two of these residues, Arg-369 and His-433, at the dimeric interface suggest a mechanism for heparin-induced protein dimerization.

  19. A Review and Comparative Analysis of Security Risks and Safety Measures of Mobile Health Apps

    Directory of Open Access Journals (Sweden)

    Karen Scott

    2015-11-01

    Full Text Available In line with a patient-centred model of healthcare, Mobile Health applications (mhealth apps provide convenient and equitable access to health and well-being resources and programs that can enable consumers to monitor their health related problems, understand specific medical conditions and attain personal fitness goals. This increase in access and control comes with an increase in risk and responsibility to identify and manage the associated risks, such as the privacy and security of consumers’ personal and health information. Based on a review of the literature, this paper identifies a set of risk and safety features for evaluating mHealth apps and uses those features to conduct a comparative analysis of the 20 most popular mHealth apps. The comparative analysis reveals that current mHealth apps do pose a risk to consumers. To address the safety and privacy concerns, recommendations to consumers and app developers are offered together with consideration of mHealth app future trends.

  20. Optimal processing for gel electrophoresis images: Applying Monte Carlo Tree Search in GelApp.

    Science.gov (United States)

    Nguyen, Phi-Vu; Ghezal, Ali; Hsueh, Ya-Chih; Boudier, Thomas; Gan, Samuel Ken-En; Lee, Hwee Kuan

    2016-08-01

    In biomedical research, gel band size estimation in electrophoresis analysis is a routine process. To facilitate and automate this process, numerous software have been released, notably the GelApp mobile app. However, the band detection accuracy is limited due to a band detection algorithm that cannot adapt to the variations in input images. To address this, we used the Monte Carlo Tree Search with Upper Confidence Bound (MCTS-UCB) method to efficiently search for optimal image processing pipelines for the band detection task, thereby improving the segmentation algorithm. Incorporating this into GelApp, we report a significant enhancement of gel band detection accuracy by 55.9 ± 2.0% for protein polyacrylamide gels, and 35.9 ± 2.5% for DNA SYBR green agarose gels. This implementation is a proof-of-concept in demonstrating MCTS-UCB as a strategy to optimize general image segmentation. The improved version of GelApp-GelApp 2.0-is freely available on both Google Play Store (for Android platform), and Apple App Store (for iOS platform).

  1. Haptics-Based Apps for Middle School Students with Visual Impairments.

    Science.gov (United States)

    Murphy, Kristen; Darrah, Marjorie

    2015-01-01

    Twenty haptics-based computer applications (apps) have been created to utilize a low-cost, force feedback haptic device, the Novint Falcon, to provide students with tactile and kinesthetic sensations while learning about math and science. These low-cost apps, developed specifically for students with visual impairments (yet practical for all students), add to the accessible resources available for math and science. This article outlines the motivation, development, and testing of these PC-based applications that incorporate computer haptics, auditory cues, and high-contrast visuals. Included is a brief overview of two of the apps, one with science content and one with math content, in order to provide the reader with some insight into the student experience. The results of testing six of the apps in classroom settings show that the device and software are feasible for teachers to implement and significant learning gains can be achieved for students who use them. Student attitudes toward the apps were positive, implying that not only are the apps useful in the classroom, but engaging as well.

  2. APP Overexpression Causes Aβ-Independent Neuronal Death through Intrinsic Apoptosis Pathway.

    Science.gov (United States)

    Cheng, Ning; Jiao, Song; Gumaste, Ankita; Bai, Li; Belluscio, Leonardo

    2016-01-01

    Accumulation of amyloid-β (Aβ) peptide in the brain is a central hallmark of Alzheimer's disease (AD) and is thought to be the cause of the observed neurodegeneration. Many animal models have been generated that overproduce Aβ yet do not exhibit clear neuronal loss, questioning this Aβ hypothesis. We previously developed an in vivo mouse model that expresses a humanized amyloid precursor protein (hAPP) in olfactory sensory neurons (OSNs) showing robust apoptosis and olfactory dysfunction by 3 weeks of age, which is consistent with early OSN loss and smell deficits, as observed in AD patients. Here we show, by deleting the β-site APP cleaving enzyme 1 (BACE1) in two distinct transgenic mouse models, that hAPP-induced apoptosis of OSNs is Aβ independent and remains cell autonomous. In addition, we reveal that the intrinsic apoptosis pathway is responsible for hAPP-induced OSN death, as marked by mitochondrial damage and caspase-9 activation. Given that hAPP expression causes OSN apoptosis despite the absence of BACE1, we propose that Aβ is not the sole cause of hAPP-induced neurodegeneration and that the early loss of olfactory function in AD may be based on a cell-autonomous mechanism, which could mark an early phase of AD, prior to Aβ accumulation. Thus, the olfactory system could serve as an important new platform to study the development of AD, providing unique insight for both early diagnosis and intervention. PMID:27517085

  3. An Analysis of WhatsApp Usage for Communication Between Consulting and Emergency Physicians.

    Science.gov (United States)

    Gulacti, Umut; Lok, Ugur; Hatipoglu, Sinan; Polat, Haci

    2016-06-01

    The aim of this study was to evaluate WhatsApp messenger usage for communication between consulting and emergency physicians. A retrospective, observational study was conducted in the emergency department (ED) of a tertiary care university hospital between January 2014 and June 2014. A total of 614 consultations requested by using the WhatsApp application were evaluated, and 519 eligible consultations were included in the study. The WhatsApp messages that were transferred to consultant physicians consisted of 510 (98.3%) photographic images, 517 (99.6%) text messages, 59 (11.3%) videos, and 10 (1.9%) voice messages. Consultation was most frequently requested from the orthopedics clinic (n = 160, 30.8%). The majority of requested consultations were terminated only by evaluation via WhatsApp messages. (n = 311, 59.9%). Most of the consulting physicians were outside of the hospital or were mobile at the time of the consultation (n = 292, 56.3%). The outside consultation request rate was significantly higher for night shifts than for day shifts (p = .004), and the majority of outside consultation request were concluded by only WhatsApp application (p WhatsApp is useful a communication tool between physicians, especially for ED consultants who are outside the hospital, because of the ability to transfer large amounts of clinical and radiological data during a short period of time.

  4. Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology.

    Science.gov (United States)

    Readhead, B; Haure-Mirande, J-V; Zhang, B; Haroutunian, V; Gandy, S; Schadt, E E; Dudley, J T; Ehrlich, M E

    2016-08-01

    Identification and characterization of molecular mechanisms that connect genetic risk factors to initiation and evolution of disease pathophysiology represent major goals and opportunities for improving therapeutic and diagnostic outcomes in Alzheimer's disease (AD). Integrative genomic analysis of the human AD brain transcriptome holds potential for revealing novel mechanisms of dysfunction that underlie the onset and/or progression of the disease. We performed an integrative genomic analysis of brain tissue-derived transcriptomes measured from two lines of mice expressing distinct mutant AD-related proteins. The first line expresses oligomerogenic mutant APP(E693Q) inside neurons, leading to the accumulation of amyloid beta (Aβ) oligomers and behavioral impairment, but never develops parenchymal fibrillar amyloid deposits. The second line expresses APP(KM670/671NL)/PSEN1(Δexon9) in neurons and accumulates fibrillar Aβ amyloid and amyloid plaques accompanied by neuritic dystrophy and behavioral impairment. We performed RNA sequencing analyses of the dentate gyrus and entorhinal cortex from each line and from wild-type mice. We then performed an integrative genomic analysis to identify dysregulated molecules and pathways, comparing transgenic mice with wild-type controls as well as to each other. We also compared these results with datasets derived from human AD brain. Differential gene and exon expression analysis revealed pervasive alterations in APP/Aβ metabolism, epigenetic control of neurogenesis, cytoskeletal organization and extracellular matrix (ECM) regulation. Comparative molecular analysis converged on FMR1 (Fragile X Mental Retardation 1), an important negative regulator of APP translation and oligomerogenesis in the post-synaptic space. Integration of these transcriptomic results with human postmortem AD gene networks, differential expression and differential splicing signatures identified significant similarities in pathway dysregulation

  5. EyePhy: Detecting Dependencies in Cyber-Physical System Apps due to Human-in-the-Loop

    Directory of Open Access Journals (Sweden)

    Sirajum Munir

    2015-07-01

    Full Text Available As app based paradigms are becoming popular, millions of apps are developed from many domains including energy, health, security, and entertainment. The US FDA expects that there will be 500 million smart phone users downloading healthcare related apps by 2015. Many of these apps are Cyber-Physical System (CPS apps. In addition to sensing, communication, and computation, they perform interventions to control human physiological parameters, which can cause dependency problems as multiple interventions of multiple apps can increase or decrease each others effects, some of which can be harmful to the user. Such dependency problems occur mainly because each app is unaware about how other apps work and when an app performs an intervention to control its target parameters, it may affect other physiological parameters without even knowing it. We present EyePhy, a system that detects dependencies across interventions by having a closer eye on the physiological parameters of the human in the loop. To do that, EyePhy uses a physiological simulator HumMod that can model the complex interactions of the human physiology using over 7800 variables. EyePhy reduces app developers’ efforts in specifying dependency metadata compared to state of the art solutions and offers personalized dependency analysis for the user. We demonstrate the magnitude of dependencies that arise during multiple interventions in a human body and the significant ability of detecting these dependencies using EyePhy.

  6. Mobile apps for pediatric obesity prevention and treatment, healthy eating, and physical activity promotion: just fun and games?

    Science.gov (United States)

    Schoffman, Danielle E; Turner-McGrievy, Gabrielle; Jones, Sonya J; Wilcox, Sara

    2013-09-01

    Mobile applications (apps) offer a novel way to engage children in behavior change, but little is known about content of commercially available apps for this population. We analyzed the content of apps for iPhone/iPad for pediatric weight loss, healthy eating (HE), and physical activity (PA). Fifty-seven apps were downloaded and tested by two independent raters. Apps were coded for: inclusion of the Expert Committee for Pediatric Obesity Prevention's (ECPOP) eight recommended strategies (e.g., set goals) and seven behavioral targets (e.g., do ≥1 h of PA per day), utilization of gaming elements, and general characteristics. Most apps lacked any expert recommendations (n = 35, 61.4 %). The mean number of recommendations among apps that used recommendations was 3.6 ± 2.7 out of 15, 56.1 % (n = 32) apps were classified as games, and mean price per app was $1.05 ± 1.66. Most apps reviewed lacked expert recommendations and could be strengthened by addition of comprehensive information about health behavior change and opportunities for goal setting. PMID:24073184

  7. ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity

    Directory of Open Access Journals (Sweden)

    Bu Guojun

    2007-07-01

    Full Text Available Abstract Background The generation of the amyloid-β peptide (Aβ through the proteolytic processing of the amyloid precursor protein (APP is a central event in the pathogenesis of Alzheimer's disease (AD. Recent studies highlight APP endocytosis and localization to lipid rafts as important events favoring amyloidogenic processing. However, the precise mechanisms underlying these events are poorly understood. ApoER2 is a member of the low density lipoprotein receptor (LDL-R family exhibiting slow endocytosis rate and a significant association with lipid rafts. Despite the important neurophysiological roles described for ApoER2, little is known regarding how ApoER2 regulates APP trafficking and processing. Results Here, we demonstrate that ApoER2 physically interacts and co-localizes with APP. Remarkably, we found that ApoER2 increases cell surface APP levels and APP association with lipid rafts. The increase of cell surface APP requires the presence of ApoER2 cytoplasmic domain and is a result of decreased APP internalization rate. Unexpectedly, ApoER2 expression correlated with a significant increase in Aβ production and reduced levels of APP-CTFs. The increased Aβ production was dependent on the integrity of the NPxY endocytosis motif of ApoER2. We also found that expression of ApoER2 increased APP association with lipid rafts and increased γ-secretase activity, both of which might contribute to increased Aβ production. Conclusion These findings show that ApoER2 negatively affects APP internalization. However, ApoER2 expression stimulates Aβ production by shifting the proportion of APP from the non-rafts to the raft membrane domains, thereby promoting β-secretase and γ-secretase mediated amyloidogenic processing and also by incrementing the activity of γ-secretase.

  8. A Mobile App for Geochemical Field Data Acquisition

    Science.gov (United States)

    Klump, J. F.; Reid, N.; Ballsun-Stanton, B.; White, A.; Sobotkova, A.

    2015-12-01

    We have developed a geochemical sampling application for use on Android tablets. This app was developed together with the Federated Archaeological Information Management Systems (FAIMS) at Macquarie University and is based on the open source FAIMS mobile platform, which was originally designed for archaeological field data collection. The FAIMS mobile platform has proved valuable for hydrogeochemical, biogeochemical, soil and rock sample collection due to the ability to customise data collection methodologies for any field research. The module we commissioned allows for using inbuilt or external GPS to locate sample points, it incorporates standard and incremental sampling names which can be easily fed into the International Geo-Sample Number (IGSN). Sampling can be documented not only in metadata, but also accompanied by photographic documentation and sketches. The module is augmented by dropdown menus for fields specific for each sample type and user defined tags. The module also provides users with an overview of all records from a field campaign in a records viewer. We also use basic mapping functionality, showing the current location, sampled points overlaid on preloaded rasters, and allows for drawing of points and simple polygons to be later exported as shape files. A particular challenge is the remoteness of the sampling locations, hundreds of kilometres away from network access. The first trial raised the issue of backup without access to the internet, so in collaboration with the FAIMS team and Solutions First, we commissioned a vehicle mounted portable server. This server box is constantly syncing with the tablets in the field via Wi-Fi, it has an uninterruptible power supply that can run for up to 45 minutes when the vehicle is turned off, and a 1TB hard drive for storage of all data and photographs. The server can be logged into via any of the field tablets or laptop to download all the data collected to date or to just view it on the server.

  9. Functional coordination of intraflagellar transport motors.

    Science.gov (United States)

    Ou, Guangshuo; Blacque, Oliver E; Snow, Joshua J; Leroux, Michel R; Scholey, Jonathan M

    2005-07-28

    Cilia have diverse roles in motility and sensory reception, and defects in cilia function contribute to ciliary diseases such as Bardet-Biedl syndrome (BBS). Intraflagellar transport (IFT) motors assemble and maintain cilia by transporting ciliary precursors, bound to protein complexes called IFT particles, from the base of the cilium to their site of incorporation at the distal tip. In Caenorhabditis elegans, this is accomplished by two IFT motors, kinesin-II and osmotic avoidance defective (OSM)-3 kinesin, which cooperate to form two sequential anterograde IFT pathways that build distinct parts of cilia. By observing the movement of fluorescent IFT motors and IFT particles along the cilia of numerous ciliary mutants, we identified three genes whose protein products mediate the functional coordination of these motors. The BBS proteins BBS-7 and BBS-8 are required to stabilize complexes of IFT particles containing both of the IFT motors, because IFT particles in bbs-7 and bbs-8 mutants break down into two subcomplexes, IFT-A and IFT-B, which are moved separately by kinesin-II and OSM-3 kinesin, respectively. A conserved ciliary protein, DYF-1, is specifically required for OSM-3 kinesin to dock onto and move IFT particles, because OSM-3 kinesin is inactive and intact IFT particles are moved by kinesin-II alone in dyf-1 mutants. These findings implicate BBS ciliary disease proteins and an OSM-3 kinesin activator in the formation of two IFT pathways that build functional cilia. PMID:16049494

  10. Call for Increased Patient Support Focus: Review and Evaluation of Mobile Apps for Tuberculosis Prevention and Treatment.

    Science.gov (United States)

    Iribarren, Sarah; Schnall, Rebecca

    2016-01-01

    Tuberculosis (TB) remains a major global public health problem and is a leading killer due to an infectious disease. Mobile applications (apps) could support TB prevention and treatment. App stores were searched and of the 1332 reviewed 24 met our inclusion criteria. For each app 11 functionalities were assessed. The majority were targeted towards clinicians (n=17), few patient focused (n=4). Most had fewer than 4 functions out of 11, inform and record being the highest. Peer reviewed publications were identified for 2 of the apps and 3 apps in testing stage were found in the grey literature. Apps for TB prevention and treatment had minimal functionality, primarily targeted clinicians, and focused on information or data collection. None were for patient self-management of care and treatment or to improve patient-provider interactions. Identifying TB patient needs and involving them in the design phase is recommended. PMID:27332418

  11. Photo dynamics of BLUF domain mutant H44R of AppA from Rhodobacter sphaeroides

    Energy Technology Data Exchange (ETDEWEB)

    Zirak, P. [Institut II - Experimentelle und Angewandte Physik, Universitaet Regensburg, Universitaetstrasse 31, D-93053 Regensburg (Germany); Penzkofer, A. [Institut II - Experimentelle und Angewandte Physik, Universitaet Regensburg, Universitaetstrasse 31, D-93053 Regensburg (Germany)], E-mail: alfons.penzkofer@physik.uni-regensburg.de; Hegemann, P.; Mathes, T. [Institut fuer Biologie, Experimentelle Biophysik, Humboldt-Universitaet zu Berlin, Invalidenstr. 42, D-10115 Berlin (Germany)

    2007-05-21

    The photo-cycle dynamics of the H44R mutant of the BLUF domain of the transcriptional anti-repressor protein AppA (AppA-H44R) from the non-sulfur anoxyphototropic purple bacterium Rhodobacter sphaeroides is studied in order to gain information on the involvement of His44 in the photo-cyclic mechanism of the AppA BLUF domain and to add information to the involved processes. The amino acid residue histidine at position 44 is replaced by arginine. A 12 nm red-shifted signalling state is formed upon blue-light excitation, while in wild-type AppA (AppA-wt) the red-shift is 16 nm. The recovery to the receptor dark state is approximately a factor of 2.5 faster ({tau}{sub rec} {approx} 6.5 min) than the recovery of the wild-type counterpart. Extended light exposure of the mutant causes photo-degradation of flavin (mainly free flavin conversion to lumichrome and re-equilibration between free and non-covalently bound flavin) and protein aggregation (showing up as light scattering). No photo-degradation was observed for AppA-wt. The quantum efficiency of signalling-state formation determined by intensity dependent absorption measurements is found to be {phi}{sub s} {approx} 0.3 (for AppA-wt: {phi}{sub s} {approx} 0.24). A two-component single-exponential fluorescence relaxation was observed, which is interpreted as fast fluorescence quenching to an equilibrium value by photo-induced electron transfer followed by slower fluorescence decay due to charge recombination. Based on the experimental findings, an extended photo-cycle model for BLUF domains is proposed.

  12. Effects of Folic Acid on Secretases Involved in Aβ Deposition in APP/PS1 Mice.

    Science.gov (United States)

    Tian, Tian; Bai, Dong; Li, Wen; Huang, Guo-Wei; Liu, Huan

    2016-01-01

    Alzheimer's disease (AD) is the most common type of dementia. Amyloid-β protein (Aβ) is identified as the core protein of neuritic plaques. Aβ is generated by the sequential cleavage of the amyloid precursor protein (APP) via the APP cleaving enzyme (α-secretase, or β-secretase) and γ-secretase. Previous studies indicated that folate deficiency elevated Aβ deposition in APP/PS1 mice, and this rise was prevented by folic acid. In the present study, we aimed to investigate whether folic acid could influence the generation of Aβ by regulating α-, β-, and γ-secretase. Herein, we demonstrated that folic acid reduced the deposition of Aβ42 in APP/PS1 mice brain by decreasing the mRNA and protein expressions of β-secretase [beta-site APP-cleaving enzyme 1 (BACE1)] and γ-secretase complex catalytic component-presenilin 1 (PS1)-in APP/PS1 mice brain. Meanwhile, folic acid increased the levels of ADAM9 and ADAM10, which are important α-secretases in ADAM (a disintegrin and metalloprotease) family. However, folic acid has no impact on the protein expression of nicastrin (Nct), another component of γ-secretase complex. Moreover, folic acid regulated the expression of miR-126-3p and miR-339-5p, which target ADAM9 and BACE1, respectively. Taken together, the effect of folic acid on Aβ deposition may relate to making APP metabolism through non-amyloidogenic pathway by decreasing β-secretase and increasing α-secretase. MicroRNA (miRNA) may involve in the regulation mechanism of folic acid on secretase expression. PMID:27618097

  13. Mining Health App Data to Find More and Less Successful Weight Loss Subgroups

    Science.gov (United States)

    2016-01-01

    Background More than half of all smartphone app downloads involve weight, diet, and exercise. If successful, these lifestyle apps may have far-reaching effects for disease prevention and health cost-savings, but few researchers have analyzed data from these apps. Objective The purposes of this study were to analyze data from a commercial health app (Lose It!) in order to identify successful weight loss subgroups via exploratory analyses and to verify the stability of the results. Methods Cross-sectional, de-identified data from Lose It! were analyzed. This dataset (n=12,427,196) was randomly split into 24 subsamples, and this study used 3 subsamples (combined n=972,687). Classification and regression tree methods were used to explore groupings of weight loss with one subsample, with descriptive analyses to examine other group characteristics. Data mining validation methods were conducted with 2 additional subsamples. Results In subsample 1, 14.96% of users lost 5% or more of their starting body weight. Classification and regression tree analysis identified 3 distinct subgroups: “the occasional users” had the lowest proportion (4.87%) of individuals who successfully lost weight; “the basic users” had 37.61% weight loss success; and “the power users” achieved the highest percentage of weight loss success at 72.70%. Behavioral factors delineated the subgroups, though app-related behavioral characteristics further distinguished them. Results were replicated in further analyses with separate subsamples. Conclusions This study demonstrates that distinct subgroups can be identified in “messy” commercial app data and the identified subgroups can be replicated in independent samples. Behavioral factors and use of custom app features characterized the subgroups. Targeting and tailoring information to particular subgroups could enhance weight loss success. Future studies should replicate data mining analyses to increase methodology rigor. PMID:27301853

  14. Cholesterol-Dependent Energy Transfer between Fluorescent Proteins—Insights into Protein Proximity of APP and BACE1 in Different Membranes in Niemann-Pick Type C Disease Cells

    Directory of Open Access Journals (Sweden)

    Bjoern von Einem

    2012-11-01

    Full Text Available Förster resonance energy transfer (FRET -based techniques have recently been applied to study the interactions between β-site APP-cleaving enzyme-GFP (BACE1-GFP and amyloid precursor protein-mRFP (APP-mRFP in U373 glioblastoma cells. In this context, the role of APP-BACE1 proximity in Alzheimer’s disease (AD pathogenesis has been discussed. FRET was found to depend on intracellular cholesterol levels and associated alterations in membrane stiffness. Here, NPC1 null cells (CHO-NPC1−/−, exhibiting increased cholesterol levels and disturbed cholesterol transport similar to that observed in Niemann-Pick type C disease (NPC, were used to analyze the influence of altered cholesterol levels on APP-BACE1 proximity. Fluorescence lifetime measurements of whole CHO-wild type (WT and CHO-NPC1−/− cells (EPI-illumination microscopy, as well as their plasma membranes (total internal reflection fluorescence microscopy, TIRFM, were performed. Additionally, generalized polarization (GP measurements of CHO-WT and CHO-NPC1−/− cells incubated with the fluorescence marker laurdan were performed to determine membrane stiffness of plasma- and intracellular-membranes. CHO-NPC1−/− cells showed higher membrane stiffness at intracellular- but not plasma-membranes, equivalent to cholesterol accumulation in late endosomes/lysosomes. Along with higher membrane stiffness, the FRET efficiency between BACE1-GFP and APP-mRFP was reduced at intracellular membranes, but not within the plasma membrane of CHO-NPC1−/−. Our data show that FRET combined with TIRF is a powerful technique to determine protein proximity and membrane fluidity in cellular models of neurodegenerative diseases.

  15. iGuide to plastic surgery: iPhone apps, the plastic surgeon, and the health care environment.

    Science.gov (United States)

    Mohan, Anita Tanniru; Branford, Olivier Alexandre

    2012-07-01

    The growth in the adoption of smartphones among clinicians has been phenomenal. The demand for medical applications, or "apps," downloaded by smartphone users has led to the development of practical and educational apps for clinicians, medical students, and patients. In addition to being a valuable resource for the clinician, mobile technologies are revolutionizing the nature and delivery of health care services. This article summarizes the current trends in the smartphone market and explores the medical apps that are currently available. PMID:22628896

  16. 46 CFR 68.5 - Requirements for citizenship under 46 U.S.C. App. 883-1.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Requirements for citizenship under 46 U.S.C. App. 883-1... Engaging in Limited Coastwise Trade § 68.5 Requirements for citizenship under 46 U.S.C. App. 883-1. A corporation seeking to establish its citizenship under the Act of September 2, 1958 (46 U.S.C. App....

  17. The Role of a Mobile App for Listening Comprehension Training in Distance Learning to Sustain Student Motivation

    OpenAIRE

    Read, Timothy; Kukulska-Hulme, Agnes

    2015-01-01

    In this article the importance of listening comprehension for language students is discussed and the possible benefits of using a mobile app to motivate its practice and development are considered. The Audio News Trainer (ANT) is presented as an example of this type of app that uses the news domain as the source of audio recordings. Three research questions related to the use of this app are outlined regarding the effectiveness of the news domain for motivating the practice of listening compr...

  18. iGuide to plastic surgery: iPhone apps, the plastic surgeon, and the health care environment.

    Science.gov (United States)

    Mohan, Anita Tanniru; Branford, Olivier Alexandre

    2012-07-01

    The growth in the adoption of smartphones among clinicians has been phenomenal. The demand for medical applications, or "apps," downloaded by smartphone users has led to the development of practical and educational apps for clinicians, medical students, and patients. In addition to being a valuable resource for the clinician, mobile technologies are revolutionizing the nature and delivery of health care services. This article summarizes the current trends in the smartphone market and explores the medical apps that are currently available.

  19. Kymographic Analysis of Transport in an Individual Neuronal Sensory Cilium in Caenorhabditis elegans.

    Science.gov (United States)

    O'Hagan, Robert; Barr, Maureen M

    2016-01-01

    Intraflagellar Transport (IFT) is driven by molecular motors that travel upon microtubule-based ciliary axonemes. In the single-celled alga Chlamydomonas reinhardtii, movement of a single anterograde IFT motor, heterotrimeric kinesin-II, is required to generate two identical motile flagella. The function of this canonical anterograde IFT motor is conserved among all eukaryotes, yet multicellular organisms can generate cilia of diverse structures and functions, ranging from simple threadlike non-motile primary cilia to the elaborate cilia that make up rod and cone photoreceptors in the retina. An emerging theme is that additional molecular motors modulate the canonical IFT machinery to give rise to differing ciliary morphologies. Therefore, a complete understanding of the trafficking of ciliary receptors, as well as the biogenesis, maintenance, specialization, and function of cilia, requires the characterization of motor molecules.Here, we describe in detail our method for measuring the motility of proteins in cilia or dendrites of C. elegans male-specific CEM ciliated sensory neurons using time-lapse microscopy and kymography of green fluorescent protein (GFP)-tagged motors, receptors, and cargos. We describe, as a specific example, OSM-3::GFP puncta moving in cilia, but also include (Fig. 1) with settings that have worked well for us measuring movement of heterotrimeric kinesin-II, IFT particles, and the polycystin TRP channel PKD-2. PMID:27514919

  20. The business of iOS app development for iPhone, iPad and iPod Touch

    CERN Document Server

    Wooldridge, Dave

    2014-01-01

    Updated and expanded for the new Apple iOS8, The Business of iOS App Development, Third Edition shows you how to incorporate marketing and business savvy into every aspect of the design and development process, giving your app the best possible chance of succeeding in the App Store. This book is written by experienced developers with business backgrounds, taking you step-by-step through cost-effective marketing techniques that have proven successful for professional iOS app creators-perfect for independent developers on shoestring budgets. No prior business knowledge is required. The pheno