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Sample records for apos varios tratamentos

  1. Evaluation of the protection behaviour of reinforcement steel against corrosion induced by chlorides in reinforced mortar specimens; Avaliacao do comportamento frente a corrosao pelo ataque de cloreto de argamassa armada apos varios tratamentos protetores

    Energy Technology Data Exchange (ETDEWEB)

    Crivelaro, Marcos

    2002-07-01

    In this work various treatments for protecting reinforcing steels against corrosion induced by chlorides have been evaluated. Additives to mortars and surface treatments given to reinforcing steels were evaluated as corrosion protection measures. In the preliminary tests the corrosion resistance of a CA 50 steel treated by immersion in nearly 50 different solutions, was determined. The solutions were prepared with tannins (from various sources) and/or benzotriazole, and during immersion, a surface film formed on the steel. The corrosion resistance of the coated steels was evaluated in a saturated Ca(OH){sub 2} solution with 5% (wt) NaCl. Preliminary tests were also carried out with mortars reinforced with uncoated steel to which tannin or lignin was added. Two organic coatings, a monocomponent and a bicomponent type, formulated specially for this investigation, with both tannin and benzotriazole, were also tested in the preliminary tests to select the coating with better corrosion protection property. The bicomponent type (epoxy coating) showed better performance than the monocomponent type coating, and the former was therefore chosen to investigate the corrosion performance on CA 50 steel inside mortar specimens. From the preliminary tests, two solutions with tannin from two sources, Black Wattle (Acacia mearnsii) and Brazilian tea (Ilex paraguariensis St. Hill), to which benzotriazole and phosphoric acid were added, were chosen. Mortar specimens reinforced with CA50 steel treated by immersion in these two solutions were prepared. Also, epoxy coated CA50 steel was tested as reinforcement inside mortar specimens. Mortars reinforced with uncoated CA50 steel were also prepared and corrosion tested for comparison. The effect of tannin and lignin as separate additives to the mortar on the corrosion resistance of uncoated steel was also studied. The reinforced mortar specimens were tested with various cycles of immersion for 2 days in 3.5% (wt) NaCl followed by with air drying for 5 days. The corrosion tests used in this investigation were gravimetric and electrochemical tests. The results showed satisfactory corrosion performance for all kinds of protection measures. However, the performance depended on the type of protection used. The best performance was obtained with tannin containing epoxy coated steel, followed by the steel treated by immersion in tannin containing solutions and finally by the addition of tannin (Black Wattle) or lignin to the mortar. All the protection measures evaluated in this study are economically viable and environmentally friendly and can therefore be considered for protecting reinforcement steels against corrosion. (author)

  2. 2D vario-scale representations based on real 3D structure

    NARCIS (Netherlands)

    Suba, R.; Meijers, B.M.; Van Oosterom, P.J.M.

    2013-01-01

    This paper focuses on 3D data structures supporting an alternative approach for creating 2D vario-scale maps. The smooth animated zooming functionality have lead us to investigate a volumetric representation of gradually changing vario-scale objects. In this paper, the principle of vario-scale maps

  3. Helicobacter pylori e o idoso dispeptico : frequencia, aspectos clinicos, endoscopicos e histologicos : evolução da doença apos tratamento clinico

    OpenAIRE

    Telma da Silva Santos

    2002-01-01

    Resumo: Objetivo: Poucos são os trabalhos na literatura que abordam a dispepsia em pacientes idosos. Os objetivos deste trabalho foram: estudar a freqüência do H. pylori na população idosa com dispepsia funcional e ulcerosa; avaliar o comportamento clínico, aspectos endoscópicos e histotágicos do idoso; e, por, fim avaliar a evolução da doença após tratamento clínico. Métodos: Foram estudados pacientes no Ambulatório de Medicina Interna do Hospital Universitáriode Taubaté, no período de abril...

  4. Textos varios

    OpenAIRE

    Autores, Varios

    2012-01-01

    Se comentan obras tales como El agro salvadoreño (1973- 1980), Cuba en el transito al socialismo (1959- 1963), Historia General de Mexico, 7 ensayos. "50 años en la historia, Lima", Guardianes de la dinastía, el compromiso del intelectual y crisis de la restauración y populismo (1875- 1911).

  5. VarioML framework for comprehensive variation data representation and exchange

    Directory of Open Access Journals (Sweden)

    Byrne Myles

    2012-10-01

    Full Text Available Abstract Background Sharing of data about variation and the associated phenotypes is a critical need, yet variant information can be arbitrarily complex, making a single standard vocabulary elusive and re-formatting difficult. Complex standards have proven too time-consuming to implement. Results The GEN2PHEN project addressed these difficulties by developing a comprehensive data model for capturing biomedical observations, Observ-OM, and building the VarioML format around it. VarioML pairs a simplified open specification for describing variants, with a toolkit for adapting the specification into one's own research workflow. Straightforward variant data can be captured, federated, and exchanged with no overhead; more complex data can be described, without loss of compatibility. The open specification enables push-button submission to gene variant databases (LSDBs e.g., the Leiden Open Variation Database, using the Cafe Variome data publishing service, while VarioML bidirectionally transforms data between XML and web-application code formats, opening up new possibilities for open source web applications building on shared data. A Java implementation toolkit makes VarioML easily integrated into biomedical applications. VarioML is designed primarily for LSDB data submission and transfer scenarios, but can also be used as a standard variation data format for JSON and XML document databases and user interface components. Conclusions VarioML is a set of tools and practices improving the availability, quality, and comprehensibility of human variation information. It enables researchers, diagnostic laboratories, and clinics to share that information with ease, clarity, and without ambiguity.

  6. "Escritos completos (relación, circulares, textos varios, libretas, cartas)" [Reseña

    OpenAIRE

    2012-01-01

    Reseña de Santa Genoveva Torres Morales, "Escritos completos (relación, circulares, textos varios, libretas, cartas)", 3 vols., ed. preparada por Bonifacio Bartolomé Herrero. Prólogo de Mariano-Sergio Mainar Elpuente, Religiosas Angélicas, Zaragoza 2012.

  7. Neuroendoscopic Intraventricular Biopsy in Children with Small Ventricles Using Frameless VarioGuide System.

    Science.gov (United States)

    Avecillas-Chasin, Josué M; Budke, Marcelo; Villarejo, Francisco

    2016-03-01

    Endoscopic biopsy for intraventricular tumors in pediatric patients with small ventricles is a challenging procedure because of the risk of morbidity during the intraventricular approach. We describe the use of the VarioGuide system for intraventricular endoscopic biopsy in 9 consecutive pediatric patients with intraventricular lesions and small ventricular size. All patients had lesions in the anterior part of the third ventricle with a median frontal and occipital horn ratio of 0.33. Patients presented with growth failure (n = 4), visual disturbances (n = 4), and seizures (n = 1). The VarioGuide system consists of an ergonomic arm with 3 joints for gross adjustment. The 3 rotational joints on the distal side of the system are adjusted according to the angles of the planned trajectory. The endoscope is adjusted to the distal side of the VarioGuide and inserted through the ring, previously set for the diameter of the endoscope and for the planned trajectory. The accuracy of the trajectory and correct ventricular cannulation are confirmed under endoscopic guidance. The biopsy is carried out according to the standard technique. In all cases, the biopsy sample provided the definitive diagnosis. Diagnoses included germinomas in 4 patients, hamartoma in 1 patient, hypothalamic astrocytoma in 2 patients, and craniopharyngioma in 2 patients. The use of the VarioGuide system for intraventricular endoscopic biopsy is highly recommended for pediatric patients with small ventricle size. This technique may help minimize the risk of unnecessary brain damage during the entrance to small ventricles.

  8. Normativa constitucional ambiental comparada de varios países sudamericanos

    Directory of Open Access Journals (Sweden)

    Deyanira Gómez Salazar

    2013-09-01

    Full Text Available Existen grandes avances en la normativa constitucional en los países del sur en cuanto a la protección ambiental, varios se destacan por sus innovaciones, mientras que otros aún poseen una normativa pobre y básica. Sin embargo, lo importante es su reglamentación y aplicación por las autoridades y los ciudadanos

  9. Petrarca, il «vario stile» e l'idea di lirica

    Directory of Open Access Journals (Sweden)

    Marco Grimaldi

    2014-07-01

    Full Text Available Il saggio analizza la diffusione della definizione di lirica contenuta nelle Etymologiae di Isidoro di Siviglia, che si fondava sulla varietà formale. Si cerca quindi di dimostrare: a il legame fra tale “varietà lirica” e il «vario stile» del sonetto proemiale del Canzoniere; b l’esistenza di un paradigma medievale della lirica come ‘poesia metricamente e stilisticamente varia’ da accostare a quello classico di ‘poesia cantata al suono della lira’ e a quello moderno di ‘poesia come espressione dell’interiorità’. The paper analyses the circulation of the definition of lyric poetry given by Isidore of Seville in his Etymologiae, which was based on formal variety. The author tries to prove: a the link between this “lyrical variety” and the «vario stile» in the first sonnet of Petrarch’s Rerum vulgarium fragmenta; b the presence of a medieval idea of lyric as ‘poetry caracterized by metrical and stylistic variety’ that we propose to add to the classical (‘poetry accompanied by music’ and modern idea (‘genre which expresses personal feelings’. 

  10. Changing trends in the treatment of Graves' disease with radioiodine: a 12-year experience in a university hospital; Mudancas evolutivas no tratamento da doenca de Graves com iodo radioativo: 12 anos de experiencia em um hospital universitario

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Marcus Vinicius Leitao de [Instituto Estadual de Diabetes e Endocrinologia (IEDE), Rio de Janeiro, RJ (Brazil)], e-mail: marcusleitao@gmail.com; Souza, Honomar Ferreira de [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Faculdade de Medicina. Dept. de Endocrinologia; Buescu, Alexandru; Vaisman, Mario [Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ (Brazil). Faculdade de Medicina. Dept. de Endocrinologia

    2009-03-15

    Objective: To evaluate the changes in clinical parameters and in the approach to patients submitted to radioiodine therapy for Graves' disease. Materials and methods: Dossiers of 226 patients submitted to radioiodine therapy for Graves' disease in the period between January 1990 and December 2001 were retrospectively evaluated. For the purposes of statistical analysis, the 12-year period was subdivided into three periods of 4 years, with a comparison of clinical and laboratory variables in these periods. Results: The authors have observed that the total number of patients referred for radioiodine therapy as well as the percentage of female patients presented a significant increase (from 62% to 86%; p = 0.005). The percentage of patients pretreated with methimazole before radioiodine therapy increased significantly (from 9.1% to 35.6%; p = 0.03). The mean radioiodine dose delivered has also presented a significant increase (from 7.6 mCi to 12.7 mCi; p = 0.000003) with a direct reflection on a higher percentage of patients cured one year after the radioiodine therapy (from 55.6% to 83.7%; p = 0.004). Conclusion: Radioiodine therapy has increasingly been accepted for treatment of patients with Graves' disease and the doses delivered have increased to achieve a permanent cure as well as a reduction of the chances of recurrence. (author)

  11. Analysis of dose in heterogeneity adjuvant radiotherapy after surgical treatment of cases of breast cancer; Analise da heterogeneidade de dose em radioterapia adjuvante apos tratamento cirurgico de casos de cancer de mama

    Energy Technology Data Exchange (ETDEWEB)

    Grechi, Bruna E.; Schwarz, Ana Paula, E-mail: anapaulaschwarz@yahoo.com.br [Centro Universitario Franciscano (UNIFRA), Santa Maria, RS (Brazil); Teston, Adriano; Rodrigues, Joanilso S. [Clinica de Radioterapia Santa Maria, Santa Maria, RS (Brazil)

    2013-12-15

    Assuming the systems planning radiotherapy recognize all body structures of the same density (d=1 g/cm³), variations in electron density within the irradiated area, as is the case of patients who undergo reconstruction mammary processes and use tissue expanders, may influence the dose distribution in the treatment and may produce heterogeneities which are not measured by changing its actual distribution into healthy tissues or in the target volume to be irradiated. Through the calculation of the algorithms' dose distribution of the XiO® planning system (Fast Fourier Transform, Convolution, Superposition, Fast Superposition e Clarkson), when using correction of heterogeneity between tissues of different densities, there was obtained a percentage ratio of dose increase in the structures of interest, and of the amount of absorbed dose by healthy organs adjacent to the target volume. (author)

  12. Biokinetics analysis of I-131 and cytogenetic dosimetry in patients, after radionuclide administration for thyroid; Analise biocinetica do iodo-131 e dosimetria citogenetica em pacientes, apos administracao do radionuclideo para o tratamento de cancer de tireoide

    Energy Technology Data Exchange (ETDEWEB)

    Nascimento, Ana Cristina de Holanda

    1996-07-01

    Thyroid cancer patients are submitted to an oral administration of {sup 131} I in order to eliminate remanescent thyroid tissue, after subtotal thyroidectomy. The average activity administered in this treatment is 3.7 GBq (ablation dose), with significant irradiation of body tissues. However, there are no conclusive results on the literature about the radiation absorbed dose of these patients. The metabolic behaviour of radioiodine in 4 patients submitted to {sup 131} I ablation therapy doses was studied, through measurements of {sup 131} I in total body, thyroid and urine samples. Cytogenetic estimates of the radiation doses of these patients were obtained through chromosomal aberration analysis in the peripheral blood lymphocytes. Our results suggest that ten days after ablation dose, almost all remanescent thyroid tissue will be eliminated and {sup 131} I will be homogeneously distributed through the patient's body. The retention of {sup 131} I in the body after the first ten days following the ablation dose may be mathematically represented by the sum of two exponential terms: the first and shorter one with a biological half-life approximately 3.2 days (effective half-life = 2.3 days) and the second one, with a biological half-life of approximately 26 days (effective half-life = 6.2 days). The absorbed dose using the average of the observed chromosomal aberrations yields in blood samples of all patients was estimated in the range of 0,3 to 0,4 Gy. (author)

  13. The ''neural'' phonetic typewriter

    Energy Technology Data Exchange (ETDEWEB)

    Kohonen, T.

    1988-03-01

    Recently, researchers have placed great hopes on artificial neural networks to perform such ''natural'' tasks as speech recognition. This was indeed one motivation for us to start research in this area many years ago at Helsinki University of Technology. This article describes the result of that research - a complete ''neural'' speech recognition system, which recognizes phonetic units, called phonemes, from a continuous speech signal. Although motivated by neural network principles, the choices in design must be regarded as a compromise of many technical aspects of those principles. As our system is a genuine ''phonetic typewriter'' intended to transcribe orthographically edited text from an unlimited vocabulary, it cannot be directed compared with any more conventional, word-based system that applies classical concepts such as dynamic time warping and hidden Markov models.

  14. Tratamento do diabetes melito gestacional

    Directory of Open Access Journals (Sweden)

    Maganha Carlos Alberto

    2003-01-01

    Full Text Available Neste artigo, os autores analisam os mais recentes avanços no tratamento do diabetes gestacional, enfatizando pontos importantes na abordagem terapêutica: dieta, exercícios, controle glicêmico, utilização da insulina, assim como a utilização de hipoglicemiantes orais. O artigo traz propostas atuais para o tratamento do diabetes melito gestacional bem como ressaltar suas peculiaridades quanto patologia clínico-obstétrica.

  15. Vario MACRO cube型元素分析仪测定硝化棉氮含量%Determination of Nitrogen Content in Nitrocellulose by Vario MACRO cube Element Analyzer

    Institute of Scientific and Technical Information of China (English)

    刘红妮; 高朗华; 胡岚; 张皋; 刘志伟; 温晓燕; 严蕊

    2013-01-01

    使用Vario MACRO cube型元素分析仪测定硝化棉氮含量.不锈钢材质炉体的两级燃烧管设计保证了硝化棉在大样品量下的完全燃烧及燃烧安全性,最大样品量可达85 mg.该方法具有简便快速、自动化程度高、结果准确性高等优点.

  16. Generación de historias de varios personajes en lenguaje natural con elementos narrativos y diálogo

    OpenAIRE

    León Aznar, Carlos

    2007-01-01

    En este trabajo de investigación se propone un sistema concreto de Generación de Lenguaje Natural capaz de crear historias con varios personajes, en las que se relaten secuencias de acciones y diálogos entre dichos personajes. Este sistema recibirá, como base de conocimiento, un conjunto determinado de datos que servirán como información a partir de la cual se creará la historia, y que describirán, de manera exhaustiva, todos los hechos o eventos que se den en una historia. El sistema de gene...

  17. Tratamento da leishmaniose tegumentar americana pelo niridazol

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    Miroslau Constante Baranski

    1970-08-01

    Full Text Available Foi empregue o niridazol um derivado do nitrotiazol, em doze pacientes com leishmaniose tegumentar americana. Em todos êles, o diagnóstico clínico da doença foi confirmado pela biópsia das lesões e em oito dêles também pela positividade da intradetermorreação de Montenegro. Oito pacientes tinham lesões mucosas metastáticas em atividade e lesões cutâneas iniciais cicatrizadas há tempo mais ou menos longo. Dois apresentavam concomitância de lesões cutâneas e mucosas em atividade, e dois tinham lesões cutâneas exclusivas. A duração da doença variou de 2 meses a 32 anos. A posologia diária do niridazol foi uniformememente de 25 mg/kg de pêso corpóreo. O medicamento foi administrado por via oral, em duas tomadas diárias, sempre com o doente internado em hospital. Quando a tolerância o permitia, o paciente recebia cinco séries de tratamento de 10 dias de duração cada, intercaladas por períodos áe suspensão da droga de 10 dias entre uma série e outra. Isso foi possível em 10 dos 12 pacientes. O tratamento foi bem tolerado em 5 doentes e de tolerância regular em 4. Mal tolerado em um paciente pela ocorrência de alucinações e excitação mental e interrompido pela péssima tolerância em dois doentes devido ao aparecimento de convulsões generalizadas com perda da consciência. O tratamento acompanhou-se de grande incidência, de efeitos colaterais. A ocorrência de para-efeitos mais intensos não foi devida às más condições hepáticas. Provas de função hepática. hemogramas, estudos bioquímicos do sangue e exames de urina, realizados antes, durante e após o tratamento, não revelaram alterações significativas. Biópsias hepáticas por punção com agulha em dez doentes, prévias e posteriores ao tratamento, não detectaram lesões hepáticas que pudessem ser atribuídas à medicação. O seguimento dos doentes prolongou-se pelo prazo de dois a 36 meses apos o tratamento. Alterações eletrocardiogr

  18. Tratamento da dor em queimados

    Directory of Open Access Journals (Sweden)

    Rodrigo José Alencar de Castro

    2013-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Apesar dos avanços, ainda é observado manejo analgésico inadequado dos pacientes com queimaduras. O objetivo desta revisão foi coletar dados sobre tratamento da dor em queimados. CONTEÚDO: Foi feita revisão sobre os mecanismos de dor, avaliação do paciente com queimadura e o tratamento farmacológico e não farmacológico. CONCLUSÕES: O manejo da dor em pacientes vítimas de queimaduras ainda é um desafio por parte da equipe multiprofissional. A avaliação frequente e contínua da resposta apresentada pelo paciente é muito importante, tendo em vista os vários momentos por que passa o paciente internado em decorrência de uma queimadura, além de uma terapêutica combinada com medicações analgésicas e medidas não farmacológicas. Entender a complexidade de alterações fisiopatológicas, psicológicas e bioquímicas apresentadas por um paciente em tratamento de queimadura é o primeiro passo para alcançar o sucesso no seu manejo analgésico.

  19. The strategic ''pull'' and operational ''push'' of total quality management in UK regional electricity service companies

    Energy Technology Data Exchange (ETDEWEB)

    McAdam, R.; McLean, J.; Henderson, J.

    2003-04-30

    The aim of this paper is to evaluate whether the UK regional electricity companies (RECs) has used total quality management (TQM) as a ''push'' or as a ''pull'' change methodology. ''Push'' is the operational improvement role of TQM; ''pull'' is the strategic or direction giving, improvement role of TQM. Following the onset of privatisation in 1990 there has been evidence of the RECs adopting TQM in both ''push'' and ''pull'' methodologies with varying degrees of success. An evaluation of the change processes involved will enable improved change models to be developed leading to increased business effectiveness in this 30 billion pounds sterling industry. Other possible benefits include the possible generalisations to other utilities such as water, roads, gas and telecoms. The research methodology includes a comparative case study analysis of five RECs, which have used TQM as their overarching approach to change. One of the cases is analysed to a more in-depth level based on the multiple case findings. The findings indicate that the ''push-pull'' analysis enables the full range of TQM activities to be evaluated in the RECs studied. Overall, there is a need to have a balanced portfolio of operational or ''push''-based TQM activity that is driven by strategic or ''pull'' based TQM planning and activity. (author)

  20. High energy X-ray laboratory ''HEXYLab''. The new facility ''HEXYTech''; Hochenergie-Roentgen-Labor ''HEXYLab''. Die neue Anlage ''HEXYTech''

    Energy Technology Data Exchange (ETDEWEB)

    Redmer, Bernhard; Hohendorf, Stefan; Kolkoori, Sanjeevareddy; Wrobel, Norma; Ewert, Uwe [BAM Bundesanstalt fuer Materialforschung und -pruefung, Berlin (Germany)

    2015-07-01

    High-energy radiography is used traditionally for the detection of defects in the thick-walled, bulky components. It is also used for testing the integrity of components for civil and security related applications (containers). The combination of high-energy emitters with digital detector arrays or line cameras allows test procedures in a shorter time compared to film or higher contrast sensitivity. The high-energy X-ray laboratory HEXYLab BAM is a joint laboratory in which future users, manufacturers and scientists can initiate and develop joint development projects. The new universal manipulation system HEXYTech forms the engineering and technical base for the most diverse requirements in HEXYLab (High Energy X-raY Lab.). With a total of 13 rotary and linear axes the diverse trajectories for tube, object and detector can be programmed. So large objects with complex geometries can be examined. 2D and 3D images can be measured by simple radiography, and laminography and computed tomography. The general rules for the application of high energy radiography with digital detectors (imaging plates, Digital detector arrays) were determined within the framework of the European project ''HEDRad'' (High Energy Digital Radiography) and included in the standard DIN EN ISO 17636-2. This article gives an overview of the testing technology and presents the possible applications on the basis of images and experiments. (PowerPoint slides). [German] Hochenergie-Radiographie wird traditionell fuer die Detektion von Defekten in dickwandigen, sperrigen Komponenten angewendet. Sie wird auch genutzt fuer die Pruefung der Komponentenintegritaet bei zivilen und sicherheitsrelevanten Anwendungen (Container). Die Kombination von Hochenergie- Strahlern mit digitalen Detektorarrays oder Zeilenkameras ermoeglicht die Pruefungsdurchfuehrung in kuerzerer Zeit im Vergleich zum Film oder mit hoeherer Kontrastempfindlichkeit. Das Hochenergie-Roentgen-Labor ''HEXYLab'&apos

  1. CAMBIOS EN LA ACTIVIDAD ENZIMÁTICA EN DUODENO Y YEYUNO DE CERDOS DURANTE VARIOS PERIODOS POSDESTETE

    Directory of Open Access Journals (Sweden)

    D. Ospina

    2011-01-01

    Full Text Available Objetivos: evaluar los cambios en la actividad enzimática intestinal de algunos cerdosdurante varios periodos posdestete. Materiales y métodos: el trabajo de campo serealizó en el Centro San Pablo, perteneciente a la Universidad Nacional de Colombia,sede Medellín. El estudio se realizó con 16 cerdos destetados a los 21 días de edad. Losanimales experimentales fueron alimentados durante 10 días con una dieta basal (DBque tuvo como componentes leche y algunos de sus derivados y que además cumplíacon los requerimientos nutricionales. Luego, los cerdos fueron sacrificados escalonadamentelos días uno, cinco, siete y diez posdestete, y se realizó extracción completa delintestino delgado, el cual fue dividido en dos secciones (duodeno y yeyuno de igualtamaño. El análisis de la actividad enzimática (APN, DPP-IV, LPH, MGA y SI se realizómediante el método de velocidades iniciales y el diseño estadístico que se empleófue completamente al azar, no obstante, los datos se analizaron mediante la aplicaciónde los modelos lineales generales (GLM y de la prueba de duncan. Resultados:se evidencia que las enzimas presentaron diferencias (P < 0,01 durante los periodosposdestete. En el día cinco se observaron cambios negativos en todas las enzimas encomparación con su estado durante el primer día posdestete; sin embargo, entre el díauno y diez posdestete se presentaron diferencias entre APN, DPP-IV y LPH (P < 0,01.Además, se encontró que la sección proximal (duodeno presentó las mayores actividadesenzimáticas (P < 0,01. Conclusiones: el destete temprano disminuye la actividadenzimática a nivel intestinal, provocando la subutilización de los nutrientes de la dietay, por ende, alta incidencia de diarreas durante esta etapa.

  2. Asma e Gravidez: Tratamento Hospitalar

    Directory of Open Access Journals (Sweden)

    Mauad Filho Francisco

    2001-01-01

    Full Text Available Objetivo: avaliar as complicações perinatais decorrentes da associação de asma e gravidez em pacientes que necessitaram hospitalização para controle da crise asmática. Método: análise retrospectiva de 12 casos de asma e gravidez que necessitaram de internação hospitalar e foram assistidos no Departamento de Ginecologia e Obstetrícia da Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, no período compreendido entre 1992 e 1996. Os parâmetros analisados foram: idade materna, acompanhamento pré-natal, tempo de permanência hospitalar, tratamento instituído, intercorrências gravídicas, idade gestacional ao parto, tipo de parto, peso ao nascer e índice de Apgar. Resultados: das 12 gestantes asmáticas, 7 não haviam iniciado o seguimento pré-natal antes da internação para o tratamento da crise asmática. Três pacientes apresentaram doença hipertensiva específica da gravidez, sendo um dos casos associado a rotura prematura de membranas e corioamnionite e outro associado a descolamento prematuro de placenta. Foram diagnosticados 2 casos de insuficiência placentária, um deles associado a trabalho de parto prematuro e transfusão feto-fetal em gestação gemelar e outro associado a oligoâmnio. Foi detectado 1 caso de oligoâmnio associado a pneumonia materna e óbito fetal e também 1 caso de polidrâmnio. Além disso, ocorreram 2 casos de parto prematuro e 3 recém-nascidos foram considerados pequenos para a idade gestacional. Conclusões: a prevenção das complicações da asma na gravidez deve ser instituída antes mesmo da concepção, enfatizando-se os aspectos educativos da paciente em relação à doença e afastando-se quando possível os fatores desencadeantes das crises, como os alergênios ambientais e o tabagismo. O tratamento deve ser instituído precocemente e a paciente deve ser acompanhada em conjunto pelo obstetra e pelo pneumologista.

  3. Oil protection &apos;&apos;John R&apos;&apos;; Oljevernaksjon &apos;&apos;John R&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    The report briefly reviews the emergency actions after the bulk ship &apos;&apos;John R&apos;&apos; ran aground off Troms on December 15, 2002. The report was worked out by the contingency and control division at the National State Pollution Control Authority (SFT). SFT mobilized their own action organization to attend to the oil pollution preparedness around the disabled ship. The Norwegian Directorate of Shipping and Navigation (SD) mobilized in order to attend to a possible emergency discharging of the ship. In the opening phase, the situation was handled by Defence Command North Norway. The report is built on logs and other written documentation from the Coast Guard and from SFT. Material from several other participants are also included. The harmful effects on the environment were kept to a minimum. Altogether oil damage was observed on 1300 - 1800 sea birds. Only minor shores in three areas were affected.

  4. Tratamento da giardiase com tinidazol

    Directory of Open Access Journals (Sweden)

    Miroslau Constante Baranski

    1975-02-01

    Full Text Available Estudou-se a eficácia terapêutica do tinidazol, um novo derivado nitroimidazólico, em trinta pacientes com giardiase. A posologia diária foi de 300 mg em 20 pacientes com idade superior a 10 anos, e de 150 mg em 10 crianças com idade inferior a 10 anos. O tratamento teve a duração de cinco dias. O diagnóstico e os controles de cura parasitológicos foram feitos pelos métodos de Hoffman, Pons & Janer e de Faust e cols. Foram realizados três controles, com intervalos de sete dias, iniciando-se na semana subsequente ao término do tratamento. Obtiveram cura parasitológica em 96,6% dos casos. Ressaltam a excelente tolerância da droga, mesmo em pacientes com grave doença fundamental ou em crianças, não se registrando efeitos colaterais. Concluem ser o tinidazol excelente droga giardicida.The Autors study the therapeutic efficacy of Tinidazole, a new nitrimidazole derivative, in the treatment of thirty patients with giardiasis. They employed the daily dosage of 300 mg for twenty patients and 150 mg for ten children, respectively with ten years of age or and less during five consecutive days. The diagnosis and the parasitological evaluation of the results of treatment were accomplished by stool examinations using zinc sulphate centrifugal-flotation technique of Faust et al. and sedimentatian-concentration technique of Hoffman, Pons and Janer. The control started one week after the treatment and consisted of three stool examinations, at one week intervals. The Authors achieved 96.6 per cent of parasitological cures. They stressed the excellent tolerance of the drug ,even by patients with serious fundamental diseases or by children. No side effects were registered. They conclude that Tinidazole is an excellent drug against Giardia lamblia infections.

  5. Tegretol no tratamento da epilepsia

    Directory of Open Access Journals (Sweden)

    Jorge Armbrust-Figueiredo

    1968-09-01

    Full Text Available O Tegretol (5-carbamil-5H-dibenzo-b,L-azepina foi usado no tratamento de 68 pacientes com epilepsia; 54 apresentavam epilepsia temporal (42 com crises psicomotoras e 12 com crises complexas, 11 epilepsia focal de projeção não temporal e 3 epilepsia centrencefálica com crises P.M. Resultados satisfatórios foram observados em 82% dos 65 pacientes com epilepsia focal; os 3 pacientes com crises P.M. não foram influenciados pelo tratamento. A ação sobre as manifestações psíquicas que acompanhavam o quadro crítico ou intercrítico das crises ficou bem evidenciada. Os pacientes melhoraram de seus sintomas na grande maioria dos casos, conseguindo adaptar-se melhor no ambiente familiar, profissional e escolar. O efeito sobre as alterações eletrencefalográficas é moderado, e a evolução clínica não acompanha as modificações dos traçados. As doses usadas, em geral de 400 a 600 mg diários, são suficientes para o controle das crises na maioria dos casos e estão muito abaixo dos limites considerados como de segurança. As reações secundárias foram observadas em pequeno número de casos e foram sempre transitórias. O Tegretol representa, em nossa opinião, recurso de valor no trataemnto das epilepsias focais, particularmente nas crises psicomotoras.

  6. Las redes académicas de Albrecht von Haller y la Sociedad Económica: un análisis de redes a varios niveles

    Directory of Open Access Journals (Sweden)

    Martin Stuber, Lothar Krempel

    2013-06-01

    Full Text Available En este artículo se ofrece un análisis de redes a varios niveles a través del ejemplo de la transferencia de plantas cultivadas dentro del contexto de las redes de correspondencia de Albrecht von Haller y la Sociedad Económica. Por medio de un procedimiento a varios niveles se analizan, una a una, la dinámica cronológica, la estructura social, la distribución espacial y la creación funcional de redes. Estos cuatro niveles de análisis de redes no están en conflicto unos con otros, sino que se complementan mutuamente. El objetivo consiste en comprender mejor cómo contribuyeron dichas redes a la transferencia internacional de conocimientos en el siglo XVIII.

  7. Evaluación de Varios Insecticidas para el Control del Cephaloleiaspcerca avagelineataPic, Plaga de la Palma Africana

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    Urueta Sandino Eduardo

    1974-04-01

    Full Text Available Resumen. Se efectuaron varios ensayos para determinar el efecto de carbofuran 1.0, 1.5 y 2. 0 kg I. A./ha; carbaril 1.5 y 2. 0 kg I. A. /ha; lindano 1.0 y 1.5 kg I. A. /ha; diazinon 0.5 lt I. A./ha; dicrotofos 0. 5 lt I. A. /ha; fosfamidon 0.6 lt. I. A/ha; y fention 0.5 lt I. A./ha, sobre adultos y larvas de Cephaloleiasp. cerca avagelineataPic., una plaga de la palma africana en Colombia. Todos los insecticidas fueron efectivos para controlar larvas de Cephaloleiasp. en cogollos, hasta por periodos de más de 30 días. El carbofuran 2.0 kg I. A./ha carbaril 2.0 kg l . A./ha y lindano 1. 5 kg I.A. /hafueron los productos más eficientes para controlar adultos de Cephaloleia. sp. protegiendo por 15 días las hojas más jóvenes. Dicrotofos 0.5 lt I. A./ha; diazinon0.5 lt l. A./ha; fention 0.5 itI. A./ha y fosfamidon 0.6 lt I. A/ha, aparentemente no fueron efectivos para controlar las formas adultas de Cephaloleiasp. Ninguno de los insecticidas fue fitotóxico para la palma africana. /Abstract. Several tests were carried out to determine the effectiveness of carbofuran 1. 0, 1.5 and 2.0 kg A.I./ha; carbaryl 1.5, 2.0 kg. A.I./ha; lindane 1.0, 1.5 kg. A.I./ha; phosphamidon 0.6 lt. A.I./ha; fenthion 0.5 lt. A.I./ha; dicrotophos 0.5 lt. A.I /ha; diazinon 0.5 lt. A.I./ha on larvae and adults of Cephaloleia. sp. near vagelineata Pic a Chrysomelidae that affects young oil palm (Elaeisguineensis leaves in Colombia. All of these insecticides controlled well Cepbaloleia sp. larvae for periods over a month. carbofuran 2 kg. A.I./ha; carbaryl 2kg. A.I./ha and lindane 1.5 kg. A. I./ha gave the best control of Cephaloleia. sp. adults, protecting young oil palm leaves up to 15 days. Dicrotophos 0.5 lts. A.I./ha; fenthion 0.5 lt. A. I./ha; phosphamidon 0.6 lt. A.I./ha; diazinon 0.5 lt. A.I./ha; apparently were not effective to control adults of Cephaloleia sp. None of the insecticides tested showed to be phytotoxic to the oil palm.

  8. The &apos;'invisible'&apos; radioactive scale

    Energy Technology Data Exchange (ETDEWEB)

    Bjoernstad, T.; Ramsoey, T

    1999-04-01

    Production and up-concentration of naturally occurring radioactive material (NORM) in the petroleum industry has attracted steadily increasing attention during the last 15 years. Most production engineers today associate this radioactivity with precipitates (scales) and sludges in production tubing, pumps, valves, separators, settling tanks etc., wherever water is being transported or treated. {sup 226}Ra and {sup 228}Ra are the most well known radioactive constituents in scale. Surprisingly little known is the radioactive contamination by {sup 210}Pb and progeny {sup 210}Bi and {sup 210}Po. These are found in combination with {sup 226}Ra in ordinary scale, often in layer of non-radioactive metallic lead in water transportation systems, but also in pure gas and condensate handling systems &apos;'unsupported'&apos; by {sup 226}Ra, but due to transportation and decay of the noble gas {sup 222}Rn in NG/LNG. This latter contamination may be rather thin, in some cases virtually invisible. When, in addition, the radiation energies are low enough for not being detectable on the equipment outer surface, its existence has for most people in the industry been a secret. The report discusses transportation and deposition mechanisms, detection methods and provides some examples of measured results from the North Sea on equipment sent for maintenance. It is concluded that a regular measurement program for this type of contamination should be mandatory under all dismantling processes of transportation and fluid handling equipment for fluids and gases offshore and onshore.

  9. Neutrino-gaseous &apos;'pancakes'&apos; and the problem of hidden mass

    Energy Technology Data Exchange (ETDEWEB)

    Doroshkevich, A.G. (AN SSSR, Moscow. Inst. Prikladnoj Matematiki)

    1983-08-01

    Taking into account peculiar velocities of neutrinos the gaseous component is shown to dominate in the central part of a cosmological &apos;'pancake'&apos; (rhosub(p) > rhosub(..nu..)), while on the average anti rhosub(b) << anti rhosub(..nu..). Therefore fragmentation of a gaseous &apos;'pancake'&apos; and later clustering of the fragments into galaxies and groups of galaxies are determined by velocity distribution and gravity of the gaseous component. The hidden mass is formed by capture of neutrinos by clustering clouds. Formation of the cluster of galaxies is connected with perturbations embracing all the neutrino-gaseous &apos;'pancake'&apos;, initial ratio of neutrino-to-gaseous densities being reestablished. It is shown that the first &apos;'pancakes'&apos; were formed at the red shifts z=5-8.

  10. Characterization and behavior in the environment of the crude oil &apos;'Prestige'&apos;; Caracterisation et comportement dans l&apos;environnement du fioul &apos;'Prestige'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-03-01

    This study presents analysis realized on the crude oil of the tanker &apos;'Prestige'&apos; which sunk the 19 november 2002. The specifications on the product and its behavior in sea water are detailed. All the analysis are compared to the &apos;'Erika'&apos; crude oil. (A.L.B.)

  11. Análisis de contenido e indexación de 1.600 resúmenes de los trabajos en varios Congreso Europeo de Medicina Familiar.

    OpenAIRE

    Jamoulle, Marc

    2015-01-01

    Análisis de contenido e indexación de 1.600 resúmenes de los trabajos en varios Congreso Europeo de Medicina Familiar Marc Jamoulle, Department of General Practice, Liege University, Belgium La comunicación en congresos de medicina de familia es un trabajo importante. La indexación de estas comunicaciones es un problema no resuelto. Manejar el conocimiento acumulado es un reto para la profesión de médico de familia. Análisis de la presentación de resúmenes para Wonca Europe 2007...

  12. La detección de trastornos mentales en la infancia en atención primaria en varios países en desarrollo .

    Directory of Open Access Journals (Sweden)

    R Giel

    1989-01-01

    Full Text Available Los autores resaltan la importancia creciente de la detección e intervención precoz en los trastornos mentales. La investigación se desarrolla por varios departamentos universitarios de forma colaboradora con la OMS. Es un estudio de screening en doble fase, donde se exponen los resultados comparados para valorar la fiabilidad como instrumento del Reporting Ouestionnaire for Children (ROC, exponen la metodología de la investigación y el trabajo desarrollado por la atención primaria y su resultado comparado con los psiquiatras.

  13. BLOWIN&apos; IN THE WIND: BOTH &apos;'NEGATIVE'&apos; AND &apos;'POSITIVE'&apos; FEEDBACK IN AN OBSCURED HIGH-z QUASAR

    Energy Technology Data Exchange (ETDEWEB)

    Cresci, G.; Mannucci, F. [INAF-Osservatorio Astrofisco di Arcetri, largo E. Fermi 5, I-50127, Firenze (Italy); Mainieri, V. [European Southern Observatory, Karl-Schwarzschild-strasse 2, D-85748 Garching bei München (Germany); Brusa, M.; Perna, M.; Lanzuisi, G. [Dipartimento di Fisica e Astronomia, Università di Bologna, viale Berti Pichat 6/2, I-40127 Bologna (Italy); Marconi, A. [Dipartimento di Fisica e Astronomia, Università degli Studi di Firenze, via G. Sansone 1, I-50019 Sesto F.no, Firenze (Italy); Piconcelli, E.; Feruglio, C.; Fiore, F.; Bongiorno, A. [INAF-Osservatorio Astronomico di Roma, via Frascati 33, I-00040 Monteporzio Catone (Italy); Maiolino, R. [Cavendish Laboratory, University of Cambridge, 19 J. J. Thomson Avenue, Cambridge (United Kingdom); Merloni, A [Max Planck Institut für Extraterrestrische Physik, Giessenbachstrasse 1, D-85748 Garching bei München (Germany); Schramm, M.; Silverman, J. D. [Kavli Institute for the Physics and Mathematics of the Universe (WPI), Todai Institutes for Advanced Study, the University of Tokyo, Kashiwanoha 5-1-5, Kashiwa-shi, Chiba 277-8568 (Japan); Civano, F., E-mail: gcresci@arcetri.astro.it [Department of Physics and Yale Center for Astronomy and Astrophysics, Yale University, PO Box 208121, New Haven, CT 06520-8121 (United States)

    2015-01-20

    Quasar feedback in the form of powerful outflows is invoked as a key mechanism to quench star formation in galaxies, preventing massive galaxies to overgrow and producing the red colors of ellipticals. On the other hand, some models are also requiring &apos;'positive'&apos; active galactic nucleus feedback, inducing star formation in the host galaxy through enhanced gas pressure in the interstellar medium. However, finding observational evidence of the effects of both types of feedback is still one of the main challenges of extragalactic astronomy, as few observations of energetic and extended radiatively driven winds are available. Here we present SINFONI near infrared integral field spectroscopy of XID2028, an obscured, radio-quiet z = 1.59 QSO detected in the XMM-COSMOS survey, in which we clearly resolve a fast (1500 km s{sup –1}) and extended (up to 13 kpc from the black hole) outflow in the [O III] lines emitting gas, whose large velocity and outflow rate are not sustainable by star formation only. The narrow component of Hα emission and the rest frame U-band flux from Hubble Space Telescope/Advanced Camera for Surveys imaging enable to map the current star formation in the host galaxy: both tracers independently show that the outflow position lies in the center of an empty cavity surrounded by star forming regions on its edge. The outflow is therefore removing the gas from the host galaxy (&apos;&apos;negative feedback&apos;&apos;), but also triggering star formation by outflow induced pressure at the edges (&apos;&apos;positive feedback&apos;&apos;). XID2028 represents the first example of a host galaxy showing both types of feedback simultaneously at work.

  14. &apos;&apos;When Cost Measures Contradict&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Montgomery, W. D.; Smith, A. E.; Biggar, S. L.; Bernstein, P. M.

    2003-05-09

    When regulators put forward new economic or regulatory policies, there is a need to compare the costs and benefits of these new policies to existing policies and other alternatives to determine which policy is most cost-effective. For command and control policies, it is quite difficult to compute costs, but for more market-based policies, economists have had a great deal of success employing general equilibrium models to assess a policy&apos;s costs. Not all cost measures, however, arrive at the same ranking. Furthermore, cost measures can produce contradictory results for a specific policy. These problems make it difficult for a policy-maker to determine the best policy. For a cost measures to be of value, one would like to be confident of two things. First one wants to be sure whether the policy is a winner or loser. Second, one wants to be confident that a measure produces the correct policy ranking. That is, one wants to have confidence in a policy measure&apos;s ability to correctly rank policies from most beneficial to most harmful. This paper analyzes empirically these two properties of different costs measures as they pertain to assessing the costs of the carbon abatement policies, especially the Kyoto Protocol, under alternative assumptions about implementation.

  15. O psicanalista no tratamento da dor

    Directory of Open Access Journals (Sweden)

    Sueli Pinto Minatti

    2012-12-01

    Full Text Available A dor se manifesta como mal-estar do corpo e no corpo, e tende a ser encaminhada para tratamento médico. O objetivo deste trabalho é analisar a queixa dolorosa do ponto de vista do tratamento psicanalítico, retomando algumas acepções relacionadas ao tratamento da dor, encontradas na obra de Freud. Partimos da experiência no trabalho em hospital pediátrico, utilizando a análise do atendimento de pacientes com queixas de dor para definir e situar a dor no campo da psicanálise, e distingui-la do campo da medicina. No texto, pode-se acompanhar a dor como signo de sofrimento e diversas formas de abordá-la tanto pelo sujeito que a porta quanto pelas instituições que propõem seu cuidado.

  16. ApoE polymorphisms in narcolepsy

    Directory of Open Access Journals (Sweden)

    Kasten Meike

    2001-08-01

    Full Text Available Summary Background Narcolepsy is a common neuropsychiatric disorder characterized by increased daytime sleepiness, cataplexy and hypnagogic hallucinations. Deficiency of the hypocretin neurotransmitter system was shown to be involved in the pathogenesis of narcolepsy in animals and men. There are several hints that neurodegeneration of hypocretin producing neurons in the hypothalamus is the pathological correlate of narcolepsy. The ApoE4 allele is a major contributing factor to early-onset neuronal degeneration in Alzheimer disease and other neurodegenerative diseases as well. Methods To clarify whether the ApoE4 phenotype predisposes to narcolepsy or associates with an earlier disease onset, we have genotyped the ApoE gene in 103 patients with narcolepsy and 101 healthy controls. Results The frequency of the E4 allele of the ApoE gene was 11% in the patient and 15% in the control groups. Furthermore, the mean age of onset did not differ between the ApoE4+ and ApoE4- patient groups. Conclusion Our results exclude the ApoE4 allele as a major risk factor for narcolepsy.

  17. Automated power system for the amplification module of the &apos;'Del'fin'&apos; high power laser. Avtomatizatsiia sistemy energopitaniia usilitel&apos;nogo modulia moshchnoi lazernoi ustanovki &apos;'Del&apos;fin

    Energy Technology Data Exchange (ETDEWEB)

    Allin, A.P.; Doroshkevich, I.L.; Kuchinskii, A.G.; Savchenko, V.M.; Senatskii, U.V.; Sklizkov, G.V.; Subbotin, L.K.; Taranchuk, V.B.

    1981-01-01

    An automated power supply subsystem in the &apos;'Del'fin'&apos; laser apparatus is described that uses a minicomputer on-line with a KAMAK device. Programs are given that are used with the automated power supply for the amplification module of the &apos;'Delfin'&apos; high power laser device for performing the functions of operational monitoring and control and the collection and preliminary processing of information arriving from the capacitor banks and the control components.

  18. Korea&apos;s 1-watt plan &apos;&apos;Standby Korea 2010&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yungrae

    2010-09-15

    Korea announced standby power of all electronics shall be reduced to below 1W by 2010. Ministry of Knowledge Economy (MKE, Korean government) and Korea Energy Management Corporation (KEMCO) established &apos;&apos;Standby Korea 2010&apos;&apos; which is a roadmap to limit standby power below 1W by 2010. Korea implemented mandatory program over a relatively short period of time, incorporating the better elements from the more established national program and adding new initiatives, such as the threat of using mandatory warning label for products that fail to meet standby power targets.

  19. Tratamento do parkinsonismo com L-Dopa

    Directory of Open Access Journals (Sweden)

    Nilton Luís Latuf

    1972-06-01

    Full Text Available São apresentados os resultados obtidos no tratamento de 54 pacientes parkinsonianos com L-Dopa. A intensidade dos sintomas foi avaliada mediante a escala NUDS (Northwestern University Disability Scales antes e após o tratamento. Os autores ressaltam a obtenção de melhores resultados no que respeita à rigidez e à discinesia, em comparação com o tremor. São apontados os efeitos colaterais, quase sempre de pequena intensidade e corrigíveis com a diminuição ou suspensão da administração medicamentosa.

  20. An integrated evaluation of formation inhomogeneity, accounting for the field &apos;'trend'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Sultanov, C.A.; Akhmodov, A.M.; Allakhverdieva, L.I.

    1979-01-01

    It is recommended that the degree of characteristic variation in the geological parameters by area be accounted for using the &apos;'trend'&apos; characteristic when evaluating the geological inhomogeneity of formations; this characteristic denotes any systematic variations which are noted in the diagram of the target under study. A method for solving these problems is proposed. A problem is solved using a sample study of the ruggedness factor of several beds in the 16th formation and the series of the 15th formation in the Starii field and the Bukhti Ilch field in Bibi-Eibat. The &apos;&apos;regression analysis&apos;&apos; program was used in drafting these models; this program was developed at the computer center of the Academy of Sciences of the Estonian SSR. A multiple correlation coefficient for square-law models was used to evaluate the &apos;'trend'&apos;.

  1. A &apos;'LIGHT'&apos;, CENTRALLY CONCENTRATED MILKY WAY HALO?

    Energy Technology Data Exchange (ETDEWEB)

    Rashkov, Valery; Pillepich, Annalisa; Deason, Alis J.; Madau, Piero [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Rockosi, Constance M. [Department of Astronomy and Astrophysics, UCO/Lock Observatory, University of California, Santa Cruz, CA 95064 (United States); Guedes, Javiera [Institute for Astronomy, ETH Zurich, 8093 Zurich (Switzerland); Mayer, Lucio [Institute of Theoretical Physics, University of Zurich, CH-9057 Zurich (Switzerland)

    2013-08-20

    We discuss a novel approach to &apos;'weighing'&apos; the Milky Way (MW) dark matter halo, one that combines the latest samples of halo stars selected from the Sloan Digital Sky Survey (SDSS) with state of the art numerical simulations of MW analogs. The fully cosmological runs employed in the present study include &apos;'Eris'&apos;, one of the highest resolution hydrodynamical simulations of the formation of a M{sub vir} = 8 Multiplication-Sign 10{sup 11} M{sub Sun} late-type spiral, and the dark-matter-only M{sub vir} = 1.7 Multiplication-Sign 10{sup 12} M{sub Sun} &apos;&apos;Via Lactea II&apos;&apos; (VLII) simulation. Eris provides an excellent laboratory for creating mock SDSS samples of tracer halo stars, and we successfully compare their density, velocity anisotropy, and radial velocity dispersion profiles with the observational data. Most mock SDSS realizations show the same &apos;&apos;cold veil&apos;&apos; recently observed in the distant stellar halo of the MW, with tracers as cold as {sigma}{sub los} Almost-Equal-To 50 km s{sup -1} between 100 and 150 kpc. Controlled experiments based on the integration of the spherical Jeans equation as well as a particle tagging technique applied to VLII show that a &apos;'heavy'&apos; M{sub vir} Almost-Equal-To 2 Multiplication-Sign 10{sup 12} M{sub Sun} realistic host produces a poor fit to the kinematic SDSS data. We argue that these results offer added evidence for a &apos;'light'&apos;, centrally concentrated MW halo.

  2. Microbiological, physicochemical and sensory evaluation of cabbage and carrot minimally processed salad after radiation treatment intended to immunocompromised patients or with special diets; Avaliacao microbiologica, fisico-quimica e sensorial de salada de repolho com cenoura minimamente processada apos o tratamento por radiacao gama destinado a pacientes imunocomprometidos ou com dietas especiais

    Energy Technology Data Exchange (ETDEWEB)

    Nunes, Thaise Cristine Fernandes

    2015-09-01

    During and after the treatment of cancer, people with HIV or transplants, the food intake can offer a well-being to the patient, because the action of eating right helps people to feel strong. Healthy people have their immune system working properly and can tolerate small amounts of bacteria. However, immunocompromised persons may not be able to and however immunocompromised people cannot fight this small amount of microorganisms and require a diet with very low microbiological count to avoid contact with potentially harmful bacteria. This is called neutropenic diet. These patients are susceptible to food contamination, so that it&apos;s not advisable the ingestion of raw products. The vegetable irradiation with low doses has the purpose of reducing the microbial load. The aim of this study was to obtain data on microbiological, sensorial e physicochemical aspects in minimally processed &apos;Primavera&apos; salad irradiated with different doses of gamma radiation designed to immunocompromised patients. It were used doses of 1.0kGy, 2.0kGy, 3.0kGy and 4.0kGy irradiated in the Multipurpose Irradiator {sup 60}Co located in Radiation Technology Center. Microbiological analyzes were performed (n=25) using Petrifilm, sensory analysis using the sensory acceptance test (n=30) and triangular (n=15) and texture analysis (n=90) in the Food Microbiology Laboratory located at the Radiation Technology Center. The texture analysis was performed with the aid of a texturometer equipped with 5 kg load cell using a triangular cutting Warner-Bratzler Knife blade probe with the descent speed of 2mm/sec. All results were expressed in Newtons (N). The results showed that for microbiological analyzes the standards were followed according to the RDC 12/01 ANVISA. For the sensory test of acceptation no difference was found among the samples, however in the triangular test could be found slight differences between samples irradiated with 4.0kGy and control and there was significant

  3. Custo comparativo do tratamento de feridas

    Directory of Open Access Journals (Sweden)

    Eline Lima Borges

    1999-06-01

    Full Text Available Este estudo compara o custo do curativo tradicional e o do preconizado pelo protocolo do setor de Estomaterapia do HC/UFMG no tratamento de diversos tipos de feridas. Ao final do trabalho, foi possível concluir que o custo do último é inferior ao do primeiro e que a freqüência na troca do curativo tradicional constitui fator de maior significância na elevação de seu custo.

  4. The &apos;'passivhaus'&apos; standard: from energy efficiency to &apos;green&apos; building; Le standard &apos;'passivhaus'&apos;: de la performance energetique a la construction &apos;'verte'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2005-10-01

    The German voluntary standard &apos;Passivhaus&apos; (passive house) leads to buildings with practically no energy consumption. The first residential buildings of this type were built in 1998 and the first tertiary buildings in 2000. Such a passive house must fulfill 5 efficiency criteria: annual space heating needs {<=} 15 kWh/m{sup 2}, U{sub v} envelope coefficient lower than 0.15 W/(m{sup 2}.K), U{sub v} of openings lower than 0.8 W/(m{sup 2}.K), airtightness {<=} 0.6 volume/hour, and total energy needs (space heating, hot water, ventilation, lighting and domestic uses) measured at the meter lower than 42 kWh/m{sup 2}.year. This article makes a status of the effective efficiency of existing passive buildings both in the residential and tertiary sectors and presents some possible ways of improvement. (J.S.)

  5. Tratamento das bexigas neurogênicas

    Directory of Open Access Journals (Sweden)

    José Antonio Levy

    1955-12-01

    Full Text Available Na micção normal existem duas fases: uma primeira, voluntária, na dependência da musculatura estriada-abdominal e do assoalho pélvico; uma segunda, reflexa, subordinada ao sistema nervoso parassimpático. Nas lesões agudas da medula, após uma fase inicial de atonia, a função vesical evolui para as formas autônoma, reflexa e não inibida, de acôrdo com a localização e a extensão da lesão. O tratamento das bexigas neurogênicas inicialmente visará manter o órgão em bom estado até que uma fase definitiva tenha sido alcançada; é por meio da lavagem contínua em sistema fechado com sonda de dupla corrente que são obtidos os melhores resultados. A segunda fase do tratamento (tratamento das seqüelas visará, em primeiro lugar, o combate ao resíduo urinário, quase sempre presente nas bexigas neurogênicas; ulteriormente cuidará da reeducação do órgão.

  6. A metisergide no tratamento da epilepsia temporal

    Directory of Open Access Journals (Sweden)

    Jorge Armbrust-Figueiredo

    1967-09-01

    Full Text Available A metisergide (butanolamida do ácido 1-metil-lisérgico foi empregada experimentalmente em 78 pacientes com epilepsia psicomotora e com alterações focais (ondas "sharp" de projeção em um dos lobos temporais, no EEG. Foram usadas doses diárias de 2 a 6 mg, associadas a 0,1 g de fenobarbital. Dos 78 pacientes, 59 responderam de maneira favorável ao tratamento, sendo que 47 deixaram de sofrer crises e 12 apresentaram diminuição acentuada da freqüência e intensidade das crises. As manifestações psíquicas também melhoraram com o tratamento, ao contrário do que geralmente acontece com outras drogas. As alterações eletrencefalográficas desapareceram ou melhoraram em 64% dos pacientes. Reações secundárias ocorreram em 39 dos pacientes, na fase inicial do tratamento, e foram de curta duração, desaparecendo espontâneamente.

  7. &apos;&apos;Social capitalism&apos;&apos; in renewable energy generation: China and California comparisons

    Energy Technology Data Exchange (ETDEWEB)

    Clark, Woodrow W. II.; Li, Xing [Clark Strategic Partners, PO Box 17975, Beverly Hills, CA 90210 (United States)

    2010-03-15

    With a population of over 1.3 billion people, demand for renewable energy is expected to grow to a USD $12 billion market in the near term. Under Renewable Energy Law (REL) in February 2005 in the People&apos;s Republic of China (PRC) passed by the National Congress, renewable energy projects will be able to receive a range of financial incentives starting in 2006, which will more than double the PRC current renewable energy generation from 7% to 15% by 2020. Most of the increase will be in hydroelectric generated power. Nonetheless, the nation and especially the provinces are moving rapidly to develop a wide range of renewable energy generation including solar, wind, geothermal and run of the river. Because China practices &apos;&apos;social capitalism&apos;&apos; as expressed in it&apos;s recurrent Five Year National Plans since 1999, the national government and all the provinces have programs, unlike many western and industrialized nations, to &apos;'plan'&apos; and provide for infrastructures. This paper concerns only the energy infrastructure sector and renewable energy generation in particular. The planning process includes financial incentives and investments which are a major part of the Chinese law focused on &apos;&apos;encouraging foreign investment industries&apos;&apos;. The key part of the law is to guarantee long-term power purchase agreements with state owned and controlled &apos;'utilities'&apos;. In short, China may have gotten the economics of the energy sector correct in its concern for planning and finance. The paper develops these energy infrastructure ideas along with the legal and financial requirements as &apos;'lessons'&apos; learned from the USA and especially California. These lessons now apply to China and allow it to learn from the American mistakes. Empirical data will be drawn from work done in China that examine the renewable energy generation and infrastructures and hence allow the RPC and its

  8. Report of working committee 4 &apos;&apos;transmission of gases&apos;&apos;; Rapport de la commission 4 &apos;&apos;transport des gaz&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Volskij, E.

    2000-07-01

    Report of the WOC 4 Transmission contains the results of works carried out during 1998-2000 by the Committee members and the three study groups. The most important is: - review of actual situation and prospects for the gas pipeline transmission system development; - report of SG-4.1 &apos;Pipeline Ageing and Rehabilitation&apos;, including analysis of pipeline steels, welding and insulation, methods of rehabilitation, the program of pipeline reconstruction; - report of SG-4.2 &apos;Emission monitoring&apos; including appraisal of gas losses and methods of lowering of methane and other emissions of the gas units in different countries; - report of SG-4.3 &apos;Pipelines Integrity Management and Safety&apos; including basic information on gas pipeline failure intensity, key elements of the Integrity Management System of the gas transmission, methods of risk evaluation and the effectiveness of the approach. (authors)

  9. Utilization of demolished composition materials of &apos;'ClimateHouses'&apos;; Verwertung des Abbruchmaterials von &apos;'KlimaHaeusern'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Knappe, Florian; Diebel, Anton; Reinhardt, Joachim; Theis, Stefanie [ifeu-Institut fuer Energie- und Umweltforschung GmbH, Heidelberg (Germany); Leiter, Elisabeth; Rosanelli, Rupert; Vieider, Andreas [Syneco, Bolzano (Italy); Feess, Walter [Firma Feess Erdbau, Kirchheim/Teck (Germany); Bonadio, Martina

    2012-09-15

    In the year 1992, an innovative concept of energy conservation was developed in order to improve the energy standards of new buildings as well as existing buildings. The model &apos;ClimateHouse&apos; has to reduce significantly the energy demand in the area of needs building and living as well as the use of fossil resources and negative impacts on the climate. First of all the authors of the contribution under consideration report on and balance the situation in the province South Tyrol with respect to the design of &apos;ClimateHouses&apos; and the use of construction materials for &apos;ClimateHouses&apos;. This also is valid for solar panels. Within a second step the authors report on how the waste management has to be arranged to other waste mass flows and waste compositions.

  10. Evaluación y clasificación de la calidad de varios cuerpos de agua en la Península de Osa

    Directory of Open Access Journals (Sweden)

    Jesús Mora Molina

    2011-10-01

    Full Text Available El agua es un elemento esencial no solo para la preservación de la vida, sino también para la conservación de la flora y fauna de la región. Su conservación y calidad están estrechamente vinculadas prácticamente a todas las actividades económicas y sociales en forma ineludible, así como a la salud de su población. A la Península de Osa se le reconoce como la zona biológica más rica de Mesoamérica.Alberga una diversidad del hábitat y riqueza biológica raramente encontrada en un área pequeña. Este exótico territorio no está exento de amenazas debido a la fragmentación y destrucción del hábitat, deforestación por la explotación de la madera y mal planeamiento en el uso de la tierra, extracción ilegal de recursos, entre ellos el oro y el crecimiento de la población en sus alrededores.El presente diagnóstico tuvo como objetivo definir la situación actual y los posibles riesgos de contaminación del recurso hídrico evaluada en varios ríos de la zona de Osa. Se muestrearon varios cuerpos de agua en la zona de Piedras Blancas que se encuentra cerca de Chacarita, así como Rincón, Puerto Jiménez y la Bahía Drake, estas últimas pertenecientes a la Península de Osa. La valoración de la calidad del agua se hizo utilizando el Índice de Clasificación Holandés.A pesar de las características de la zona, esta ya presenta una contaminación incipiente, dependiendo del sitio y el mes del muestreo. La contaminación en los ríos depende de la densidad poblacional; sin embargo, los alcances de la contaminación en cada zona dependerán del tipo de suelo, del desarrollo urbanístico y la cobertura boscosa. Típico ejemplo de esta variabilidad son los poblados de Puerto Jiménez, el de Piedras Blancas y el de la Bahía de Drake.

  11. &apos;&apos;Substantial Margin of Safety&apos;&apos;: A New Approach to HLW Disposition

    Energy Technology Data Exchange (ETDEWEB)

    Power, M. S.

    2002-02-28

    In the Spring of 2001, the National Research Council published &apos;&apos;Disposition of High-Level Waste and Spent Nuclear Fuel: The Continuing Societal and Technical Challenges.&apos;&apos; (1) While finding the technical case for deep geologic disposal of high-level waste and spent fuel robust, the report focused new attention on societal issues and decision-making. The report appeared against a backdrop of heightened controversy about the development of a geologic repository at Yucca Mountain, Nevada. This paper identifies three principal reasons for the National Research Council committee&apos;s finding that &apos;&apos;Difficulties in achieving public support have been seriously underestimated in the past, and opportunities to gain public trust have been missed.&apos;&apos;

  12. Meta-análisis de la definición del uso racional de energía en varios países

    Directory of Open Access Journals (Sweden)

    Néstor Nova Arévalo

    2012-12-01

    Full Text Available En el presente artículo se realiza una comparación estadística de la definición emitida por varios países sobre el concepto de Uso Racional de la Energía – URE -, usando análisis textual como método de descomposición semántica de los conceptos. Se calculan los coeficientes de correlación de Pearson y se construyen los círculos de correlación aplicando análisis de componentes principales. Como resultado se encuentran amplias diferencias entre las definiciones de los países latinos y la Unión Europea; la definición declarada por Colombia solo es similar a la de México. Se concluye que una de las razones por la cuales el Protocolo de Kioto no ha sido efectivo, es que existen definiciones divergentes del concepto de URE, lo cual modifica el horizonte de planeación de cada país. Acciones conjuntas como las de la Comunidad Europea dejan entrever la eficacia de las estrategias cuando existe unidad desde la concepción hasta la ejecución.

  13. Analisis de un problema logístico a varios niveles en la industria del automovil. DIseño de soluciones aproximadas

    Directory of Open Access Journals (Sweden)

    Cristina Delgado

    2002-01-01

    Full Text Available En este trabajo se analiza un problema planteado muy recientemente a los autores por los responsables de un operador logístico situado en Villafría (Burgos. Este operador trabaja para una empresa fabricante de componentes de automóviles, gestionando y realizando las operaciones de entrega a clientes y recogida de materia prima. En este modelo se incluyen varios niveles de decisión fuertemente interaccionados entre sí que tienen como fin último la minimización del coste de estas operaciones (entrega de pedidos a clientes y recogida de materia prima. Aunque sea un modelo aparentemente demasiado específico y para una situación muy concreta, entendemos que su análisis resulta interesante, puesto que cada vez se tiende a considerar y analizar las operaciones logísticas de forma global y no de forma individualizada. Dada la complejidad del modelo en esta primer trabajo se realiza la descripción del mismo y se propone un primer y sencillo procedimiento heurístico para su resolución. Se analizan las soluciones obtenidas con datos reales.

  14. Calidad del agua de riego y su posible efecto en los rendimientos agrícolas en la Empresa de Cultivos Varios Sierra de Cubitas

    Directory of Open Access Journals (Sweden)

    Camilo Bonet Pérez

    2011-01-01

    Full Text Available Los altos niveles de Na+ y Cl-, presentes en el agua empleada para el riego en la empresa de cultivos varios Sierra de Cubitas, unido a los síntomas de toxicidad y poco desarrollo vegetativo del cultivo de la papa han llevado a la dirección del Ministerio de la Agricultura a plantear la necesidad de valorar si se justifica mantener los niveles de siembra previstos del citado cultivo en esta Empresa. El estudio realizado indica que si bien el efecto tóxico sobre el cultivo puede estar presente, no es el único factor que limita actualmente los rendimientos agrícolas. Los niveles de Na+ y Cl- encontrados en el agua pueden producir toxicidad sobre el cultivo de la papa; incrementándose estos con la tecnología de riego empleada, por lo que en la empresa incide decisivamente en el resultado productivo el uso y mal manejo de aguas de mala calidad. El estudio recomienda el empleo de adaptaciones al sistema de riego para disminuir los efectos negativos sobre los rendimientos.

  15. &apos;et&apos; special: &apos;&apos;E-world of energy&apos;&apos;; &apos;et&apos;-special: &apos;&apos;E-world of energy&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2001-02-01

    The &apos;et&apos; special on the conference &apos;E-world of energy&apos;, held from February 13 - 15, 2001 in Essen (Germany) presents contributions of experts who offer solutions to issues and many topical questions arising in the business of traders and utilities as participants of (international) energy markets at various stages of transition towards workable competition. The translated titles of the 15 contributions reproduced in this &apos;et&apos; special indicate the major contents of the conference papers: 1. Internet-based wholesale power trading as a competitive option to the power exchange. 2. Forward graphs in European electricity markets. 3. Portfolio management in energy trading. 4. Risk management concepts in energy trading. 5. E-commerce as a driving force of a change in the energy markets. 6. eHuman resources management - a vital aspect of corporate success. 7. A brand policy for electricity? 8. Is it really only the price that counts for the customers? 9. The City Power network: an example of successful customer loyalty strategy for local and regional utilities. 10. The Call Center, an important instrument for customer loyalty programmes. 11. eCommerce or eLlusion? 12. eBusiness as a corporate strategy. 13. Meeting the challenges of increasing IT requirements. 14. IT solutions for transmission and distribution network management. 15. Target costing - pinpointed cost planning and control for the energy supply industry. (orig./CB) [German] In dem &apos;et&apos;-Special zur Konferenz &apos;E-world of energy&apos;, die vom 13.- 15. Februar 2001 in Essen stattfand, bieten Experten Loesungsvorschlaege fuer die aktuellen Fragen und Probleme an, die sich auf dem Weg zu liberalisierten Energiemaerkten stellen. Die folgenden Titel der 15 Beitraege geben eine Uebersicht ueber den Inhalt der Konferenzbeitraege. Themen: 1. Internetbasierte Grosshandelsmaerkte als Konkurrenz zu Energieboersen 2. Forward-Kurven in europaeischen Strommaerkten 3

  16. Crystal balls, virtual realities and &apos;storylines&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Courtney, R.S.

    2001-07-01

    &apos;'Projections'&apos; of anthropogenic climate change reported in the Third Assessment Report (TAR) of the UN Intergovernmental Panel on Climate Change (IPCC) are assessed to be based on pseudo-science. (author)

  17. Posterior &apos;'Nutcracker'&apos; phenomenon in a patient with abdominal aortic aneurysm

    Energy Technology Data Exchange (ETDEWEB)

    Puig, Stefan [Department of Radiology, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna (Austria); Department of Emergency Medicine, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna (Austria); Stuehlinger, Hermann Georg; Domanovits, Hans [Department of Emergency Medicine, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna (Austria); Staudenherz, Anton [Department of Emergency Medicine, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna (Austria); Department of Nuclear Medicine, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna (Austria); Zebenholzer, Karin [Department of Emergency Medicine, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna (Austria); Department of Neurology, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna (Austria); Rebhandl, Winfried [Department of Surgery, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna (Austria); Prokop, Mathias [Department of Radiology, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna (Austria)

    2002-07-01

    We report on a posterior &apos;'nutcracker'&apos; phenomenon due to an abdominal aortic aneurysm in a patient with a retro-aortic left renal vein. A 71-year-old man with a known abdominal aortic aneurysm presented in the emergency room with mild hematuria and flank pain. Computed tomography angiography revealed an aortic aneurysm, which compressed the left renal vein between the aorta and the vertebral column. Compression of the left renal vein, due to the aorta with consecutive congestion and hematuria as well as flank pain, was previously described as nutcracker phenomenon. In case of a retro-aortic left renal vein, increase of the aortic diameter can lead to compression of the renal vein and furthermore to the classical signs and symptoms of the &apos;'nutcracker'&apos; phenomenon, even though the aneurysm is not ruptured or there are no aorto-caval or aorto-left renal vein fistulas. (orig.)

  18. Pediculectomia para o tratamento de discopatia toracolombar.

    OpenAIRE

    2011-01-01

    http://dx.doi.org/10.5007/2175-7925.2011v24n2p103A discopatia toracolombar é uma afecção compressiva da coluna espinhal provocada pela herniação do núcleo pulposo do disco intervertebral. Cursa com sinais brandos de dor a quadros severos de paralisia dos membros pélvicos. O tratamento instituído depende do local e da gravidade das compressões, neste ponto, objetiva-se com este trabalho relatar o caso de uma cadela sem raça definida, sete anos, com quadro de paresia dos membros pélvicos que ap...

  19. Tratamento dos datos analíticos

    OpenAIRE

    Yebra Biurrun, María del Carmen

    2008-01-01

    Esta unidade didáctica é a primeira toma de contacto do alumnado co estudo do tratamento dos datos analíticos e a comprobación da súa calidade. Este estudo poderase completar máis adiante dentro do programa desta materia cando se presente o resto dos parámetros de calidade dos métodos analíticos. A importancia deste tema radica en que unha vez obtidos os datos analíticos, o primeiro aspecto que se ten que considerar é a verificación da calidade dos mesmos en termos de exactitude e precisió...

  20. a eficácia do tratamento

    OpenAIRE

    Fonseca, Tânia

    2011-01-01

    Trabalho apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Licenciada em Fisioterapia. Objectivo: O objectivo desta revisão sistemática é comprovar a relação entre a articulação têmporo-mandibular (ATM) e alterações posturais e ressaltar a importância e a eficácia do tratamento fisioterapêutico nas alterações posturais para melhora dos sintomas de disfunção temporomandibular (DTM). Metodologia: pesquisa de estudos datados entre 2000 e...

  1. Diretrizes brasileiras para o tratamento da narcolepsia

    OpenAIRE

    Alóe, Flávio; ALVES, Rosana Cardoso; Araújo, John F.; Azevedo, Alexandre; Bacelar, Andrea; Bezerra,Márcio; Bittencourt, Lia Rita Azeredo; BUSTAMANTE, Guilherme; CARDOSO, Tania Aparecida Marchiori de Oliveira; ECKELI, Alan L.; Fernandes, Regina Maria França; Goulart, Leonardo; Pradella-Hallinan,Márcia; Hasan,Rosa; Sander, Heidi Haueisen

    2010-01-01

    Este artigo relata as conclusões da reunião de consenso da Associação Brasileira de Sono com médicos especialistas brasileiros sobre o tratamento da narcolepsia, baseado na revisão dos artigos sobre narcolepsia publicados entre 1980 e 2010. Os objetivos do consenso são valorizar o uso de agentes avaliados em estudos randomizados placebo-controlados, emitir recomendações de consenso para o uso de outras medicações e informar pontos importantes a respeito da segurança e efeitos adversos das med...

  2. Tratamento focal e perifocal contra Aëdes aegypti

    OpenAIRE

    Milton Moura Lima; Mario B. Aragão

    1987-01-01

    Em quatro bairros da cidade do Rio de Janeiro, foram feitos ensaios de tratamento focal com abate granulado a 1 ppm e perifocal com pó molhável de Sumition a 2,5%. Esses tratamentos foram feitos tanto isoladamente quanto em conjunto e, também, associados à aplicação de inseticida a ultrabaixo volume. Os índices prediais, levantados um mês depois de terminado o trabalho, mostraram que o tratamento focal dispensa qualquer medida auxiliar. O tratamento perifocal mostrou-se inócuo e incapaz de im...

  3. Fossil sources: &apos;&apos;Running out&apos;&apos; is not the problem

    Energy Technology Data Exchange (ETDEWEB)

    Scott, D.S. [Victoria Univ., BC (Canada). Inst. for Integrated Energy System

    2005-01-01

    In which we discuss reserves, resources and the mythology that, sooner or later, our fossil sources will be gone. Then, to help appreciate the real reason fossil reserves will ultimately vanish, we evoke Weary Willie&apos;s clown routine &apos;sweeping up the spotlight.&apos; (Author)

  4. Principles and some applications of &apos;&apos;zero field nuclear magnetic resonance&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Llor, A.; Virlet, J.

    1987-10-01

    The method known as &apos;&apos;zero field NMR&apos;&apos; is reviewed. The technique allows the observation of nuclear dipolar and quadrupolar interactions in powder samples, which may otherwise be possible in high field on monocristals only. The anisotropy due to the magnetic field is removed although sensitivity is preserved. This method is compared to other Nuclear Resonance spectroscopies: its originality lies in the measurement of the coherent evolution of the system in zero field after a perturbation induced by suddenly switching the magnetic field. The Fourier transform of the &apos;&apos;zero field free induction decay&apos;&apos; then gives the &apos;&apos;zero field spectrum&apos;&apos;. The ideal experiment is described with its adaptations due to experimental constraints, as realized in our laboratory at Saclay and in the laboratory of A. Pines at Berkeley. We present with our first measurements a review of most of the results published to date on spin 1/2 as well as spin 1/2 (quadrupolar) nuclei. Possible future developments of the method are also discussed.

  5. Cloning and Expression of Apolipoprotein E3 and Its Variant apoE2 and apoE4

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    In order to obtain three isoforms of apolipoprotein E (apoE), the cDNA encoding apoE3 was obtained by RT-PCR from normal human liver tissue. Site-directed mutagenesis was used to obtain the cDNAs encoding apoE2 and apoE4 isoforms. The 3 cDNAs were subcloned into vector pGEM-3Z and verified by DNA sequencing. The expression recombinant which can express the target protein as a (His) 6-tagged fusion was constructed by subcloning apoE cDNA into vector pT7-PL. The purified proteins were gained by Ni-NTA column. The SDS-PAGE results revealed the 6 His fusion proteins (apoE2, apoE3 and apoE4) were correctly expressed and purified successfully.

  6. PRONOSTICANDO EL ÍNDICE ENSO VARIOS PASOS EN ADELANTE MEDIANTE TÉCNICAS DE MODELAMIENTO NO LINEAL FORECASTING ENSO SEVERAL STEPS AHEAD THROUGH NONLINEAR MODELING TECHNIQUES

    Directory of Open Access Journals (Sweden)

    Giovanni Salini Calderón

    2010-12-01

    Full Text Available Se indica cómo manejar una gran base de datos consistente de series temporales no lineales, aplicando distintas técnicas de modelamiento no lineal a estas series. Aunque no existen guías explícitas de manipulación de series temporales no lineales en la profusa bibliografía actual, existen diferentes enfoques que pueden ser tomados en cuenta. Para ello se estudió una base de datos mensual correspondiente a datos del Fenómeno del Niño (ENSO, entre los años 1866 y 2006. Se explica cómo debe manipularse esta base de datos que poseen características de no linealidad, la cual será usada para hacer pronósticos varios pasos en adelante. Se aplicaron dos test estándar: Información Mutua Promedio (AMI y Falsos Vecinos más Cercanos (FNN. Se obtuvo el espaciamiento óptimo de los datos, así como el número de datos hacia atrás necesarios para pronosticar valores hacia el futuro. Luego, se diseñaron varios modelos de redes neuronales artificiales (RNA, con diferentes reglas de aprendizajes, funciones de transferencia, elementos de procesamiento (o neuronas en la capa escondida, etc., que permitieron hacer pronóstico de hasta 20 pasos en adelante. Las mejores redes correspondieron a aquellas que poseían como regla de aprendizaje la Regla Delta y la Regla Extendida, con función de transferencia sigmoide y tangente hiperbólica. El tipo de RNA usada fue una de multicapas alimentada hacia adelante y entrenada mediante la técnica de propagación hacia atrás. Se probaron redes con una, dos capas ocultas y sin ninguna capa. El mejor modelo que se obtuvo resultó ser uno consistente de una capa oculta.We indicate how to handle a large database consisting of nonlinear time series, applying different nonlinear modelling techniques to this kind of times series. Nowadays in the current references there is no explicit guide of how to manipulate data from nonlinear time series; however, there are approaches that can be taken account. To this end

  7. 2001 &apos;&apos;You Have the Power&apos;&apos; campaign [Federal Energy Management Program]. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-01-01

    The Tasks of 2001 &apos;&apos;You Have the Power&apos;&apos; campaign by the Federal Energy Management Program (FEMP) are: Task 1--Interagency Planning Meetings; Task 2--Ear Day Event; Task 3--Earth Day and Energy Awareness Month Activities; Task 4--Regional Target; Task 5--Outreach Tools and Campaign Products; Task 6--Private Sector Participation; Task 7--&apos;&apos;You Have the Power&apos;&apos; on the FEMP Web Site; and Task 8--Effective Communications.

  8. &apos;&apos;Activity based costing&apos;&apos; in radiology; &apos;&apos;Activity based costing&apos;&apos; in der Radiologie

    Energy Technology Data Exchange (ETDEWEB)

    Klose, K.J. [Klinik fuer Strahlendiagnostik, Medizinisches Zentrum fuer Radiologie, Philipps-Universitaet, Marburg (Germany); Boettcher, J. [pphc GmbH, Ammersbeck (Germany)

    2002-05-01

    Background: The introduction of diagnosis related groups for reimbursement of hospital services in Germany (g-drg) demands for a reconsideration of utilization of radiological products and costs related to them. Methods: Traditional cost accounting as approach to internal, department related budgets are compared with the accounting method of activity based costing (ABC). The steps, which are necessary to implement ABC in radiology are developed.Conclusions: The introduction of a process-oriented cost analysis is feasible for radiology departments. ABC plays a central role in the set-up of decentralized controlling functions within this institutions. The implementation seems to be a strategic challenge for department managers to get more appropriate data for adequate enterprise decisions. The necessary steps of process analysis can be used for other purposes (Certification, digital migration) as well. (orig.) [German] Hintergrund. Die Oekonomisierung der Medizin in Deutschland, die in der beabsichtigten Einfuehrung der kostenhomogenen Verguetungsklassen nach den &apos;&apos;diagnosis related groups - DRG&apos;s'&apos; ihren vorlaeufigen Hoehepunkt finden soll, erfordert eine Neuorientierung im Einsatz und in der Beurteilung der Wirtschaftlichkeit radiologischer Verfahren.Methode. Traditionelle Kostenrechnungen bzw. Verfahren zur internen Budgetierung werden der Prozesskostenbetrachtung (&apos;&apos;activity based costing&apos;&apos; - ABC) gegenuebergestellt, deren auf radiologische Belange zugeschnittene Methodik Schritt fuer Schritt entwickelt wird.Ergebnisse. Die Betrachtung radiologischer Arbeitsprozesse auf der Basis des ABC gestattet anhand der bisher publizierten Ergebnisse eine bessere Einschaetzung von Steuerungsimpulsen, die zu einer Effizienzsteigerung in radiologischen Prozessen fuehren koennen.Schlussfolgerungen. Die Einfuehrung einer prozessorientierten Kostenanalyse ist fuer vielfaeltige Belange einer Radiologieabteilung moeglich. Sie stellt

  9. Lufenuron no tratamento da dermatofitose em gatos?

    Directory of Open Access Journals (Sweden)

    Regina R. Ramadinha

    2010-02-01

    Full Text Available Em função de controvérsias sobre a eficácia do lufenuron no tratamento da dermatofitose causada por Microsporum canis, o efeito da droga foi avaliado em 46 gatos (30 com lesões cutâneas e 16 portadores assintomáticos atendidos no Hospital Veterinário da Universidade Federal Rural do Rio de Janeiro, Brasil. O diagnóstico foi estabelecido através da lâmpada de Wood, da cultura fúngica e, adicionalmente, na maioria dos animais sintomáticos, pela avaliação histopatológica da pele. Os animais foram tratados com 120mg/kg de lufenuron, a cada 21 dias (quatro doses; a droga mostrou-se eficaz no tratamento de 29 dos 30 felinos que apresentaram a forma clínica da dermatofitose, bem como no de todos os animais assintomáticos. O único felino que não teve cura clínica completa havia recebido várias doses de dexametasona antes do inicio do tratamento. Em um animal gestante, foram utilizadas duas doses do lufenuron e não foi observada qualquer alteração clínica e morfológica nos filhotes. Nenhum dos animais tratados teve qualquer reação adversa ao medicamento. Vinte dias após o último tratamento, o exame micológico resultou negativo em 45 dos felinos estudados (98%. Embora o lufenuron tenha o custo um pouco mais elevado do que o do cetoconazol, é uma droga que apresenta praticidade e margem de segurança bem maiores. Vale ressaltar que o sucesso do tratamento está diretamente relacionado à correta utilização da droga, assim como a perfeita higienização do ambiente e dos utensílios dos animais.Due to discrepancies regarding the effectiveness of lufenuron in treating dermato-phytosis caused by Microsporum canis the effect of this drug was checked in 46 cats (30 with cutaneous lesions and 16 asymptomatic carriers treated in the Veterinary Hospital of the Federal Rural University of Rio de Janeiro, Brazil. The diagnosis was based on Wood's lamp examination and fungal cultures. Biopsies were only performed in symptomatic

  10. ApoE (Apolipoprotein E) Genotyping

    Science.gov (United States)

    ... Home Visit Global Sites Search Help? APOE Genotyping, Alzheimer Disease Share this page: Was this page helpful? Formal ... help in the diagnosis of probable late onset Alzheimer disease (AD) in symptomatic adults. It is called susceptibility ...

  11. European day &apos;&apos;in town, without my car&apos;&apos;; Journee europeen &apos;&apos;en ville, sans ma voiture&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-10-01

    70 million inhabitants took part in the day &apos;&apos;In town, without my car&apos;&apos; on 22 September of this year. It is a great success for this European first. The objective of Energie-Cites association being to promote sustainable local energy policies, that is to say policies aimed at improving energy efficiency, increasing the use of renewable energy sources and limiting nuisance and pollution linked to energy consumption, the association is pleased that this event helped focus public attention on transport. It is indeed in this sector that uncontrolled upswings in energy consumption and greenhouse gas emissions are the most important. This report presents the evaluation of this European initiative and details the actions in some towns. (A.L.B.)

  12. Adesão ao tratamento da ambliopia

    Directory of Open Access Journals (Sweden)

    Arakaki Mara Regina

    2004-01-01

    Full Text Available OBJETIVO: Avaliar a influência da adesão no resultado do tratamento da ambliopia. MÉTODOS: Foi feito estudo retrospectivo avaliando a resposta ao tratamento da ambliopia em 151 crianças portadoras de ambliopia, tratadas com esquema de oclusão diária, com o número de dias variando de acordo com a idade da criança. Os pacientes foram separados em dois grupos que diferiam entre si pela adesão ou não ao tratamento. RESULTADOS: Observou-se que o tratamento teve melhores resultados nas crianças de 4 a 7 anos e que aderiram ao tratamento; as crianças que aderiram ao tratamento necessitaram de tempo menor de permanência em tratamento. Mesmo crianças com idade superior a 7 anos tiveram resultados positivos com a oclusão. CONCLUSÃO:O tratamento oclusivo é um meio terapêutico eficiente desde que haja a cooperação do paciente.

  13. The German &apos;'Energiewende'&apos;. Evaluation after the Paris-agreement; Die Deutsche Energiewende. Bewertung nach dem Klima-Abkommen von Paris

    Energy Technology Data Exchange (ETDEWEB)

    Roth, Eike

    2016-08-01

    The World-Climate-Summit 2016 in Paris agreed to exacerbated goals for climate protection. This paper will scrutinize whether Germany can comply with its Paris-obligations by continuing the ongoing German &apos;'Energiewende'&apos;. The result is clear-cut: The German &apos;'Energiewende'&apos; is inadequate. Due to the cap-and-trade system of the EU the &apos;''Energiewende'&apos;.

  14. Investigation of vertebral &apos;&apos;end plate sclerosis&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S.W. [Dept. of Rehabilitation Sciences, Hong Kong Polytechnic Univ., Hung Hom (Hong Kong); Mathie, A.G.; Jackson, J.E. [Diagnostic Radiology, Royal Postgraduate Medical School, Hammersmith Hospital, London (United Kingdom); Hughes, S.P.F. [Div. of Surgery, Anaesthetics and Intensive Care, London (United Kingdom)

    2001-08-01

    To evaluate the association between vertebral &apos;&apos;end plate sclerosis&apos;&apos; and neck pain. A retrospective study was carried out of lateral cervical spine radiographs with a Picture Archive and Communication System (PACS). Two hundred patients&apos; files were randomly assessed, comprising four equal groups, A to D. The mean ages of the patients were 62{+-}7.4 years, 61{+-}7.5 years, 40{+-}5.6 years and 23{+-}5.6 years respectively. In group A, all patients had symptoms of neck pain and a radiographic diagnosis of &apos;&apos;end plate sclerosis&apos;&apos; of the cervical spine. In groups B to D, asymptomatic patients were recruited and their age groups were 50-69, 30-49 and 10-29 years respectively. Using the PACS, the radiographic density and the sagittal diameter, thickness and area of the end plates at the C5 level were measured. Results and conclusions: No significant differences were found in the radiographic density of the end plates either between the symptomatic and asymptomatic groups (groups A and B), or between different age groups (groups B, C and D). A significant increase in end plate area and thickness was found, however, in both group B (P<0.005) and group C (P<0.01) in comparison with group D. This indicates that the extent of end plate sclerosis increases with age. Our results suggest that the radiographic density of cervical vertebral end plates correlates neither with neck pain nor with increasing age. The radiological sign of &apos;&apos;end plate sclerosis&apos;&apos; may be over-reported, further limiting its value in the assessment of patients with cervical spondylosis. (orig.)

  15. prevenção e tratamento

    OpenAIRE

    Sousa, Andreia Margarida Ferreira de

    2011-01-01

    Trabalho apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Licenciada em Fisioterapia. Sensação retardada de dor muscular (SRDM) é uma lesão por esforço muscular que se desenvolve após o exercício excêntrico, mas a eficácia do tratamento de fisioterapia ainda não foi sistematicamente avaliado. Esta revisão sistemática teve como objectivo reunir informação sobre as medidas de prevenção e/ou as medidas terapêuticas sobre os efeitos de SRDM...

  16. HEMOFILIAS: FISIOPATOLOGIA, DIAGNÓSTICO E TRATAMENTO

    Directory of Open Access Journals (Sweden)

    Roberta Truzzi COLOMBO, Gerson ZANUSSO JÚNIOR

    2013-12-01

    Full Text Available A hemofilia é um grave distúrbio hereditário da coagulação sanguínea, causada pela deficiência da atividade coagulante do fator VIII (hemofilia A ou IX (hemofilia B. A doença é decorrente de alterações nos genes codificantes destes fatores localizados no braço longo do cromossomo sexual X. Assim sua ocorrência no sexo masculino é quase que exclusiva, devido o homem apresentar somente um cromossomo X. A gravidade da doença pode variar em severa, moderadamente severa e leve, após dosagem dos fatores VIII e IX da coagulação. Uma das complicações mais temíveis dos pacientes com esta doença refere-se ao desenvolvimento de inibidores, que são anticorpos direcionados contra os fatores infundidos. O diagnóstico da doença é realizado através de exames laboratoriais, principalmente pelo coagulograma completo e dosagem de fatores específicos, baseando-se nas manifestações clínicas apresentadas pelo paciente. A hemofilia não tem cura e a base do seu tratamento é a infusão do concentrado do fator deficiente. No entanto, pacientes podem desenvolver inibidores específicos para os fatores infundidos e, nestes casos as alternativas de tratamento são o uso da biotecnologia para novos medicamentos e o uso da terapia gênica

  17. ECU tendon &apos;'dislocation'&apos; in asymptomatic volunteers

    Energy Technology Data Exchange (ETDEWEB)

    Petchprapa, Catherine N. [New York University Langone Medical Center, Hospital for Joint Diseases, Department of Radiology, New York, NY (United States); Meraj, Seema [Zwanger-Pesiri Radiology Group, Lindenhurst, NY (United States); Jain, Nidhi [New York University School of Medicine, New York University Langone Medical Center, Department of Radiology, New York, NY (United States)

    2016-06-15

    Assess extensor carpi ulnaris (ECU) tendon position in the ulnar groove, determine the frequency of tendon &apos;'dislocation'&apos; with the forearm prone, neutral, and supine, and determine if an association exists between ulnar groove morphology and tendon position in asymptomatic volunteers. Axial proton density-weighted MR was performed through the distal radioulnar joint with the forearm prone, neutral, and supine in 38 asymptomatic wrists. The percentage of the tendon located beyond the ulnar-most border of the ulnar groove was recorded. Ulnar groove depth and length was measured and ECU tendon signal was assessed. 15.8 % of tendons remained within the groove in all forearm positions. In 76.3 %, the tendon translated medially from prone to supine. The tendon &apos;'dislocated'&apos; in 0, 10.5, and 39.5 % with the forearm prone, neutral and supine, respectively. In 7.9 % prone, 5.3 % neutral, and 10.5 % supine exams, the tendon was 51-99 % beyond the ulnar border of the ulnar groove. Mean ulnar groove depth and length were 1.6 and 7.7 mm, respectively, with an overall trend towards greater degrees of tendon translation in shorter, shallower ulnar grooves. The ECU tendon shifts in a medial direction when the forearm is supine; however, tendon &apos;'dislocation'&apos; has not been previously documented in asymptomatic volunteers. The ECU tendon medially translated or frankly dislocated from the ulnar groove in the majority of our asymptomatic volunteers, particularly when the forearm is supine. Overall greater degrees of tendon translation were observed in shorter and shallower ulnar grooves. (orig.)

  18. Implications of effects &apos;&apos;adaptive response&apos;&apos;, &apos;&apos;low-dose hypersensitivity&apos;&apos; und &apos;&apos;bystander effect&apos;&apos; for cancer risk at low doses and low dose rates; Implikationen der Effekte &apos;&apos;adaptive response&apos;&apos;, &apos;&apos;low-dose hypersensitivity&apos;&apos; und &apos;&apos;bystander effect&apos;&apos; fuer das Krebsrisiko bei niedrigen Dosen und Dosenraten

    Energy Technology Data Exchange (ETDEWEB)

    Jacob, P (comp.)

    2006-07-01

    A model for carcinogenesis (the TSCE model) was applied in order to examine the effects of &apos;&apos;Low-dose hypersensitivity (LDH)&apos;&apos; and the &apos;&apos;Bystander effect (BE)&apos;&apos; on the derivation of radiation related cancer mortality risks. LDH has been discovered to occur in the inactivation of cells after acute exposure to low LET radiation. A corresponding version of the TSCE model was applied to the mortality data on the Abomb survivors from Hiroshima and Nagasaki. The BE has been mainly observed in cells after exposure to high LET radiation. A Version of the TSCE model which included the BE was applied to the data on lung cancer mortality from the workers at the Mayak nuclear facilities who were exposed to Plutonium. In general an equally good description of the A-bomb survivor mortality data (for all solid, stomach and lung tumours) was found for the TSCE model and the (conventional) empirical models but fewer parameters were necessary for the TSCE model. The TSCE model which included the effects of radiation induced cell killing resulted in non-linear dose response curves with excess relative risks after exposure at young ages that were generally lower than in the models without cell killing. The main results from TSCE models which included cell killing described by either conventional survival curves or LDH were very similar. A sub multiplicative effect from the interaction of smoking and exposure to plutonium was found to result from the analysis of the Mayak lung cancer mortality data. All models examined resulted in the predominant number of Mayak lung cancer deaths being ascribed to smoking. The interaction between smoking and plutonium exposures was found to be the second largest effect. The TSCE model resulted in lower estimates for the lung cancer excess relative risk per unit plutonium dose than the empirical risk model, but this difference was not found to be statistically significant. The excess relative risk dose responses

  19. The human apoE7 and apoE4 transgenic mice models

    Institute of Scientific and Technical Information of China (English)

    孙明增; 琦祖和

    2001-01-01

    To scrutinize the disorders caused by human mutant apoE7/apoE4, human apoE4 and E7 transgenic mice were established with microinjection technique to examine molecular genetic phenomena in vivo. The integration and expression of h-apoE mutant genes in transgenic mice were determined with Southern blot, Northern blot and ELISA. The current studies indicated that the transgenes and the phenotypes regarding expression of transgenes could be transmitted stably in transgenic lines. The levels of serum lipid in transgenic mice showed the characteristics of hyperlipidemia. Besides, behavior tests demonstrated the degeneration of learning and memory in transgenic mice. Short life span was observed in 2 transgenic lines. After fed with high lipid food high serum lipid was found both in normal and transgenic mice, but their mechanism regulating lipid metabolism was different. It was also verified that the human apoE mutants located at either N-terminal or C-terminal had the same pathogenesis regarding disorders of lipid metabolism in murine.

  20. Coral bleaching and ocean &apos;&apos;hot spots&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Goreau, T.J. (Global Coral Reef Alliance, Chappaqua, NY (United States)); Hayes, R.L. (Howard Univ., Washington, DC (United States). College of Medicine)

    1994-05-01

    Global sea-surface temperature maps show that mass coral-reef bleaching episodes between 1983 and 1991 followed positive anomalies more than 1 deg C above long-term monthly averages (&apos;&apos;hot spots&apos;&apos;) during the preceding warm season. Irregular formation, movement, and disappearance of hot spots make their detailed long-term prediction impossible, but they can be tracked in real time from satellite data. Monitoring of ocean hot spots and of coral bleaching is needed if the Framework Convention of Climate Change is to meet its goal of protecting the most temperature sensitive ecosystems. 47 refs, 3 figs

  1. Heavy cluster decay of trans-zirconium &apos;'stable'&apos; nuclides

    Energy Technology Data Exchange (ETDEWEB)

    Poenaru, D.N.; Greiner, W.; Ivascu, M.; Sandulescu, A.

    1985-12-01

    By using the analytical superasymmetric fission model it is shown that all &apos;'stable'&apos; nuclei lighter than lead with Z>40 are metastable relative to the spontaneous emission of nuclear clusters. An even-odd effect is included in the zero point vibration energy. Half-lives in the range 10/sup 40/--10/sup 50/ s are obtained for Z>62. The region of metastability against these new decay modes is extended beyond that for ..cap alpha.. decay and in some cases, in the competing region, the emission rates for nuclear clusters are larger than for ..cap alpha.. decay.

  2. Improved Security Via &apos;&apos;Town Crier&apos;&apos; Monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Johnston, R. G.; Garcia, A. R. E.; Pacheco, A. N.

    2003-02-26

    Waste managers are increasingly expected to provide good security for the hazardous materials they marshal. Good security requires, among other things, effective tamper and intrusion detection. We have developed and demonstrated a new method for tamper and intrusion detection which we call the &apos;&apos;town crier method&apos;&apos;. It avoids many of the problems and vulnerabilities associated with traditional approaches, and has significant advantages for hazardous waste transport. We constructed two rudimentary town crier prototype systems, and tested them for monitoring cargo inside a truck. Preliminary results are encouraging.

  3. Focus on &apos;&apos;regulation management&apos;&apos;. Information material - documentation; Brennpunkt &apos;'Regulierungsmanagement'&apos;. Materialienband

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    With the new Energy Economy Act coming into force and regulation authorities being established, the public utilities providing gas and electricity are starting the implementation of regulation. This creates a new field of activity: The regulation management. The regulation manager in a public utility has a wide field of functions. He or she is responsible for the organisation of the enterprise with regard to the regulation authority. He must coordinate various divisions of the enterprise taking into consideration the interest of the regulation authority and take steps to form a common understanding. The meeting called &apos;&apos;Focus on Regulation Management&apos;&apos; provides an insight into the most important tasks of a regulation manager, giving information useful for establishing an efficient regulation management system. In the first part of the meeting, the basics and tasks of regulation management and the legal protection towards the regulation authorities are dealt with. Furthermore, the president of the states&apos; committee in the BNetzA, Mr. Peter Franke, will introduce the present fields of activity, reporting about first experiences gained with the network cost requests. In the second part, practitioners from the enterprises report about their experiences with the implementation of regulation management. This includes especially data management, an effective reporting system and the implementation of a relationship management between the regulation authority and the enterprise. The meeting closes with a speech on the subject of comparing methods and benchmarking in the network.

  4. Do we need a &apos;&apos;green medicine&apos;&apos;?; Brauchen wir &apos;&apos;Gruene Medizin?&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, M.; Daschner, F.; Scherrer, M. [Universitaetsklinikum Freiburg (Germany)

    2006-07-01

    Spontaneously, we do associate &apos;&apos;green medicine&apos;&apos; with terms like naturopathy, natural healing substances, herbal active agents, homeopathy, healthy food, preventive medicine and similar things, and finally we think of ecology. This is the focus of the following article. First of all, the following question arises: Are there any environment-friendly and cost-saving alternatives to the present medicine? There is an increasing number of environment-caused diseases. Therefore, a medicine not coping with the environment is not credible. In today&apos;s medicine, for example, there are too many persistent detergents, water-polluting disinfectants, and many disposable materials. Too much water ist consumed, whereas the use of renewable energies is only limited. And too little natural healing methods are applied in diagnostics and therapy. Presently, in Germany, 16,7 million in-patients are treated in Germany, 1,16 million out-patients have surgeries in 2166 hospitals by ca. 1,1 million medical staff. All this work needs energy and materials which bring various risks to environment and the patients. During the last two decades, however, many efforts were made in the field of environment protection in medicine. There is hardly a hospital left which has not taken measures of protecting the environment. In the branch-specific quality management system KTQ (=cooperation for transparency and quality in the health system). environment protection measures are interrogated and systematically assessed.

  5. The &apos;mini&apos; and &apos;micro&apos; energy sources and their limitations; Les &apos;'minis'&apos; et &apos;'micros'&apos; sources d&apos;energie et leurs limites

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2004-03-01

    The &apos;Science and defense 2003&apos; colloquium took place in Paris on December 2 and 3. It was organized by the general delegation of armament (DGA), the French atomic energy commission (CEA) with the participation of the national center of scientific research (CNRS) and the French ministry of research and new technologies. The main topic was the needs and the solutions implemented in the domain of energy sources both for civil and military portable applications. This article make a general summary of the content of this colloquium only in the domain of small power energy sources: emergence of new miniaturized portable devices (phones, computers, cameras, autonomous medical systems, wireless communication systems, soldiers equipments, drones etc..), improvement of batteries energy density and price, new needs linked with new functionalities, technological challenges (energy generation and recovery systems, miniaturized fuel-cells, use of recoverable energy sources, implantation of power sources in the human body etc..), new technological files (new electrode materials, micron- or sub-micron scale mechanical and electronic components, sensors, micro-motors, transfer of microelectronics technologies, hybrid systems..), international competition. (J.S.)

  6. The German &apos;'Energiewende'&apos;. Evaluation after the Paris-agreement; Die Deutsche Energiewende. Bewertung nach dem Klima-Abkommen von Paris

    Energy Technology Data Exchange (ETDEWEB)

    Roth, Eike

    2016-12-15

    The World-Climate-Summit 2016 in Paris agreed to exacerbated goals for climate protection. This paper will scrutinize whether Germany can comply with its Paris-obligations by continuing the ongoing German &apos;'Energiewende'&apos;. The result is clear-cut: The German &apos;'Energiewende'&apos; is inadequate. Due to the cap-and-trade system of the EU the &apos;'Energiewende'&apos; can in no way contribute to climate protection.

  7. Performance of &apos;'ductless'&apos; personalized ventilation in conjunction with displacement ventilation: Impact of intake height

    Energy Technology Data Exchange (ETDEWEB)

    Halvonova, Barbora [Department of Building Services, Slovak University of Technology in Bratislava, 813 68 Bratislava (Slovakia); International Centre for Indoor Environment and Energy, Department of Civil Engineering, Technical University of Denmark (Denmark); Melikov, Arsen K. [International Centre for Indoor Environment and Energy, Department of Civil Engineering, Technical University of Denmark (Denmark)

    2010-04-15

    The importance of the intake positioning height above the floor level on the performance of &apos;'ductless'&apos; personalized ventilation (&apos;'ductless'&apos; PV) in conjunction with displacement ventilation (DV) was examined with regard to the quality of inhaled air and of the thermal comfort provided. A typical office room with two workstations positioned one behind the other was arranged in a full-scale room. Each workstation consisted of a table with an installed &apos;'ductless'&apos; PV system, PC, desk lamp and seated breathing thermal manikin. The &apos;'ductless'&apos; PV system sucked the clean and cool displacement air supplied over the floor at four different heights, i.e. 2, 5, 10 and 20 cm and transported it direct to the breathing level. Moreover, two displacement airflow rates were used with a supply temperature adjusted in order to maintain an exhaust air temperature of 26 C. Two pollution sources, namely air exhaled by one of the manikins and passive pollution on the table in front of the same manikin were simulated by constant dosing of tracer gases. The results show that the positioning of a &apos;'ductless'&apos; PV intake height up to 0.2 m above the floor will not significantly influence the quality of inhaled air and thermal comfort. (author)

  8. &apos;&apos;Measuring the Costs of Climate Change Policies&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Montgomery, W. D.; Smith, A. E.; Biggar, S. L.; Bernstein, P.M.

    2003-05-09

    Studies of the costs of climate change policies have utilized a variety of measures or metrics for summarizing costs. The leading economic models have utilized GNP, GDP, the &apos;&apos;area under a marginal cost curve,&apos;&apos; the discounted present value of consumption, and a welfare measure taken directly from the utility function of the model&apos;s representative agent (the &apos;&apos;Equivalent Variation&apos;&apos;). Even when calculated using a single model, these metrics do not necessarily give similar magnitudes of costs or even rank policies consistently. This paper discusses in non-technical terms the economic concepts lying behind each concept, the theoretical basis for expecting each measure to provide a consistent ranking of policies, and the reasons why different measures provide different rankings. It identifies a method of calculating the &apos;&apos;Equivalent Variation&apos;&apos; as theoretically superior to the other cost metrics in ranking policies. When regulators put forward new economic or regulatory policies, there is a need to compare the costs and benefits of these new policies to existing policies and other alternatives to determine which policy is most cost-effective. For command and control policies, it is quite difficult to compute costs, but for more market-based policies, economists have had a great deal of success employing general equilibrium models to assess a policy&apos;s costs. Not all cost measures, however, arrive at the same ranking. Furthermore, cost measures can produce contradictory results for a specific policy. These problems make it difficult for a policy-maker to determine the best policy. For a cost measures to be of value, one would like to be confident of two things. First one wants to be sure whether the policy is a winner or loser. Second, one wants to be confident that a measure produces the correct policy ranking. That is, one wants to have confidence in a policy measure&apos;s ability to correctly rank

  9. Nuclear waste disposal. A wicked and highly conflict bearing societal problem; Nukleare Entsorgung. Ein &apos;'wicked'&apos; und hoechst konfliktbehaftetes Gesellschaftsproblem

    Energy Technology Data Exchange (ETDEWEB)

    Brunnengraeber, Achim; Mez, Lutz [Freie Univ. Berlin (Germany). Forschungszentrum fuer Umweltpolitik; Di Nucci, Maria Rosaria; Schreuers, Miranda [Freie Univ. Berlin (Germany)

    2012-12-15

    The final disposal of nuclear wastes is called &apos;'messy'&apos; or &apos;'wicked'&apos; in the political science literature. The highly complicated problems are characterized by a number of features such as intra- and inter-generational aspects and ethical questions. In the case of stakeholders the differences concern ideologies, interests, merits and preferences that cause conflicts. The search for solutions is complicated due to interacting political, social, ecologic, economic and technical aspects. The concepts &apos;&apos;wicked problems&apos;&apos; and &apos;'multi-level-governance'&apos; are promising approaches to solve the complicated situation.

  10. ELABORATION OF NOT LARGE MOBILE MODULAR INSTALLATION &apos;&apos;AQUA - EXPRESS&apos;&apos; (300 L/H) FOR LRW CLEANING

    Energy Technology Data Exchange (ETDEWEB)

    Karlin, Yurii; Dmitriev, Sergey; Iljin, Vadim; Ojovan, Mihail; Burcl, Rudolf

    2003-02-27

    Mobile modular installation &apos;'Aqua-Express'&apos; is a liquid low level and intermediate level radioactive waste (LL&ILRW) treatment facility, intended for not large research centers and other organizations, which activity causes the formation of a few quantity (up to 500 m3/year) of low and intermediate level radioactive waste water. Mobile modular installation &apos;'Aqua-Express'&apos; has the following features: (1) filtration, sorption and ultrafiltration units are used for LL&ILRW purification; (2) installation &apos;'Aqua-Express'&apos; consists of a cascade of three autonomous aqueous liquid waste-purifying installations; (3) installation &apos;'Aqua-Express'&apos; is a mobile installation; the installation can be transported by car, train, ship, or plane, as well as placed in a standard transport (sea or railway) container; (4) installation &apos;'Aqua-Express'&apos; does not includes any technological equipment for conditioning the secondary radioactive waste. Productivity of the installation &apos;'Aqua-Express'&apos; by purified water depends on composition of the initial liquid waste and makes up to 300 l/h. In present report is described the design of installation &apos;'Aqua-Express'&apos;, theory of LRW purification in the installation &apos;'Aqua-Express'&apos; and some results of its use at cleaning real radioactive waters at State unitary enterprise - MosNPO &apos;'Radon'&apos;.

  11. Comparative analysis of several digital methods to recognize diatoms Análisis comparativo de varios métodos digitales para el reconocimiento de diatomeas

    Directory of Open Access Journals (Sweden)

    Josué Álvarez-Borrego

    2010-08-01

    Full Text Available In this paper, several methods are presented and compared in order to choose the best digital algorithm to recognize the diatoms species. A digital system of invariant correlation to position and rotation is constructed. Based in a binary ring mask an average signature filter for a selected image is produced in four different ways and compared with variance spectrum modified methodology using four different ways too. It is conclusive that the best methodology for this case is presented in the first method when the binary mask with a nonlinear filter is used without high frequencies enhanced in the variance spectrum of the input image using an average filter of 10 input rotated images. Moreover the confidence level for this case was 100%. The second best case was for the average filter f18, with the same confidence level, but where the difference in time is more than one minute. One of the advantages of these kinds of methodologies is that an entire process can be repeated in the same way without mistakes and the diatoms images are kept save in a hard disk of the computer, so everybody can see again the diatom information of some special localization of the ocean.En este artículo, se presentan y se comparan varios métodos para escoger el mejor algoritmo digital para reconocer especies de diatomeas. Se propone un sistema digital de correlación invariante a posición y rotación el cual está basado en una mascarilla binaria con cuatro diferentes caminos a seguir que produce una firma promedio para una cierta imagen seleccionada. Estos cuatro diferentes modos de correlación se comparan con una nueva metodología de espectro de varianza modificada que también utiliza cuatro maneras distintas de correlación. Es concluyente que los mejores resultados corresponden al método que utiliza la máscara binaria con una firma promedio de 10 imágenes rotadas y el uso de un filtro no lineal y sin realce del contenido de frecuencias del espectro de

  12. &apos;Teleparallel&apos; dark energy

    Energy Technology Data Exchange (ETDEWEB)

    Geng, Chao-Qiang, E-mail: geng@phys.nthu.edu.tw [Department of Physics, National Tsing Hua University, Hsinchu 300, Taiwan (China); National Center for Theoretical Sciences, Hsinchu 300, Taiwan (China); Lee, Chung-Chi, E-mail: g9522545@oz.nthu.edu.tw [Department of Physics, National Tsing Hua University, Hsinchu 300, Taiwan (China); Saridakis, Emmanuel N., E-mail: Emmanuel_Saridakis@baylor.edu [CASPER, Physics Department, Baylor University, Waco, TX 76798-7310 (United States); National Center for Theoretical Sciences, Hsinchu 300, Taiwan (China); Wu, Yi-Peng, E-mail: s9822508@m98.nthu.edu.tw [Department of Physics, National Tsing Hua University, Hsinchu 300, Taiwan (China)

    2011-10-25

    Using the &apos;teleparallel&apos; equivalent of General Relativity as the gravitational sector, which is based on torsion instead of curvature, we add a canonical scalar field, allowing for a nonminimal coupling with gravity. Although the minimal case is completely equivalent to standard quintessence, the nonminimal scenario has a richer structure, exhibiting quintessence-like or phantom-like behavior, or experiencing the phantom-divide crossing. The richer structure is manifested in the absence of a conformal transformation to an equivalent minimally-coupled model.

  13. Manual de Protocolos de Tratamento da Neuro-oncologia

    OpenAIRE

    Felix,Francisco H. C.; Juvenia B. Fontenele

    2016-01-01

    Manuscrito de texto de revisão dos protocolos de tratamento utilizados pela neuro-oncologia do Centro Pediátrico do Câncer. Protocolo aqui significa um esquema de tratamento baseado em um ensaio clínico patrocinado por grandes grupos cooperativos de tratamento do câncer infantil. Nenhum destes protocolos inclui o texto completo ou trechos dos protocolos originais de pesquisa. Os pacientes tratados em nosso centro seguindo estes protocolos não estã...

  14. Dietilcarbamazina no tratamento da filariose bancroftiana

    Directory of Open Access Journals (Sweden)

    Gerusa Dreyer

    1997-06-01

    Full Text Available Os autores realizaram uma ampla revisão sobre o tratamento da filariose bancroftiana com a droga dietilcarbamazina. Os aspectos interessantes sobre o histórico de sua descoberta e os conceitos básicos de sua farmacologia foram relatados de forma resumida. Ênfase especial, por outro lado, foi dada às especulações feitas pelos diversos autores sobre os achados intrigantes descritos na literatura. Foram trazidos os novos avanços sobre o conhecimento da doença, como por exemplo, a visualização pela ultra-sonografia do verme vivo de Wuchereria bancrofti, no seu hospedeiro natural, o homem. Isso possibilitou a compreensão de muitos dos achados aparentemente paradoxais encontrados na literatura sobre o tratamento da infeção com a DEC. Assim, devido à inexistência de uma droga sucessora que reunisse efeitos micro e macrofilaricidas ideais e aos novos conhecimentos sobre a bancroftose e sobre a própria dietilcarbamazina, foi-lhe conferido um novo realce. Esses aspectos a colocaram numa posição de destaque no cenário da infecção, à época do seu quase cinqüentenário de existência.The authors presented a detailed review about the tratment of bancroftian filariasis with diethylcarbamazine. The interesting aspects about the drug discovery and the basic concepts about its pharmacology were reported in a summarised form. On the other hand, emphasis was made about the speculation done by several authors about the intringuing findings regarding its efficacy reported in the literature. Latter, it was brought the new advances about the disease, as for example, the visualization by ultrasound of living Wuchereria bancrofti adult worm on its natural host3/4the human being. This made possible the comprehension of several paradoxical issues reported, focusing the treatment of infection using diethylcarbamazine. So far, because of the lack of ideal drug with micro and macrofilaricidal properties, together with the new understand about the

  15. Etiology and implications of dense cavitary &apos;'photopenia'&apos; on myocardial perfusion scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Dae, M.; Canhasi, B.; Botvinick, E.; Olvera, S.; Schechtmann, N.; Engelstad, B.; Hattner, R.; Schiller, N.; O' Connell, W.; Faulkner, D.

    1985-07-01

    Dense cavitary &apos;'photopenia'&apos; was observed on 21 of 200 consecutive stress perfusion scintigrams. A prominent finding in many cases, it sometimes occupied only a portion of the region overlying the ventricular cavity, was often seen in some projections and not others, and was frequently adjacent to myocardial perfusion defects. To distinguish an etiology among reduced cavitary radioactivity, relatively increased background radioactivity, or reduced radioactivity in overlying myocardium, quantitative analysis of cavitary, lung and myocardial radioactivity was performed in patients with dense cavitary &apos;'photopenia,'&apos; with and without lung uptake, and compared with results from studies showing increased lung uptake without cavitary photopenia and with normal studies. The results showed that dense cavitary photopenia was related to reduced radioactivity in overlying myocardium. Correlative imaging studies performed with echocardiography and contrast ventriculography confirmed this relationship to myocardial scar in 15 of 21 patients in whom associated akinesis or dyskinesis was seen. Hence, dense cavitary photopenia on stress perfusion scintigraphy is due to a dense myocardial perfusion abnormality, and is often indicative of related scar and an associated severe contraction abnormality.

  16. Considerations about the apparent &apos;&apos;superluminal expansions&apos;&apos; observed in astrophysics

    Energy Technology Data Exchange (ETDEWEB)

    Recami, E.; Castellino, A.; Maccarrone, G.D.; Rodono, M.

    1986-06-11

    The orthodox models devised to explain the apparent &apos;&apos;superluminal expansions&apos;&apos; observed in astrophysics - and here briefly summarized and discussed together with the experimental data - do not seem to be too much successful, especially when confronted with the most recent observations, suggesting complicated expansion patterns, even with possible accelerations. At this point it may be, therefore, of some interest to explore the possible alternative models in which actual Superluminal motions take place. To prepare the ground, we start from a variational principle, introduce the elements of a tachyon mechanics within special relativity, and argue about the expected behaviour of tachyonic objects when interacting (gravitationally, for instance) among themselves or with ordinary matter. We then review and develop the simplet &apos;&apos;Superluminal models&apos;&apos;, paying particular attention to the observations which they would give rise to. We conclude that some of them appear to be physically acceptable and are statistically favoured with respect to the orthodox ones.

  17. &apos;'VaneCAM'&apos; - the third generation of camshaft adjustment systems; &apos;'VaneCAM'&apos; - Nockenwellenversteller der dritten Generation

    Energy Technology Data Exchange (ETDEWEB)

    Knecht, A. [Hydraulik-Ring GmbH, Nuertingen (Germany). Entwicklung Motorentechnik; Stephan, W. [Hydraulik-Ring GmbH, Nuertingen (Germany); Hannibal, W. [Fachhochschule Suedwestfalen, Iserlohn (Germany). Labor fuer Konstruktion und CAE-Anwendungen

    2002-04-01

    Continuously variable camphasers are now well established for modern spark-ignition engines in high-volume production. With the latest generation of camshaft adjustment systems using the vane-type actuator principle, it is possible to move rapidly and reliably through a large adjustment angle. The layout of these adjusting systems is very simple. The production costs are low in comparison to the first generation of camphasers using spur/helical gears to vary the valve timing. The new-generation systems are mechatronic, with the function depending on the coordination and tuning of hydraulic actuation and engine electronics. The term &apos;VaneCAM&apos; is used for the continuously variable systems of this new generation supplied by Hydraulik-Ring in Nuertingen, Germany. (orig.) [German] Stufenlos wirkende Nockenwellenversteller haben sich an modernen Ottomotoren in den letzten Jahren in der Grossserie etabliert. Mit der neuesten Generation von Nockenwellenverstellern, die nach dem Schwenkmotor-Prinzip aufgebaut sind, lassen sich grosse Verdrehwinkel sehr schnell und betriebssicher verstellen. Der Aufbau dieser Versteller ist einfach, und die Herstellkosten sind gering im Vergleich zur ersten Generation von Verstellern. Bei den Systemen der neuen Generation handelt es sich um mechatronische Systeme, deren Funktion von dem Zusammenspiel und der Abstimmung von hydraulischer Ansteuerung und Motorelektronik abhaengt. Mit dem Begriff &apos;VaneCAM&apos; werden die stufenlos wirkenden Systeme dieser neuen Generation von Hydraulik-Ring aus Nuertingen bezeichnet. (orig.)

  18. Preparation of data relevant to &apos;&apos;Equivalent Uniform Burnup&apos;&apos; and Equivalent Initial Enrichment&apos;&apos; for burnup credit evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Nomura, Yasushi; Okuno, Hiroshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Murazaki, Minoru [Tokyo Nuclear Service Inc., Tokyo (Japan)

    2001-11-01

    Based on the PWR spent fuel composition data measured at JAERI, two kinds of simplified methods such as &apos;&apos;Equivalent Uniform Burnup&apos;&apos; and &apos;&apos;Equivalent Initial Enrichment&apos;&apos; have been introduced. And relevant evaluation curves have been prepared for criticality safety evaluation of spent fuel storage pool and transport casks, taking burnup of spent fuel into consideration. These simplified methods can be used to obtain an effective neutron multiplication factor for a spent fuel storage/transportation system by using the ORIGEN2.1 burnup code and the KENO-Va criticality code without considering axial burnup profile in spent fuel and other various factors introducing calculated errors. &apos;&apos;Equivalent Uniform Burnup&apos;&apos; is set up for its criticality analysis to be reactivity equivalent with the detailed analysis, in which the experimentally obtained isotopic composition together with a typical axial burnup profile and various factors such as irradiation history are considered on the conservative side. On the other hand, Equivalent Initial Enrichment&apos;&apos; is set up for its criticality analysis to be reactivity equivalent with the detailed analysis such as above when it is used in the so called fresh fuel assumption. (author)

  19. Production of intermediate vector meson resonances in the process {tau}{yields}{pi}&apos;'{+-}{pi}'&apos;0{nu}

    Energy Technology Data Exchange (ETDEWEB)

    Casaus, J.; Mana, C.

    1997-07-01

    We present a study on the invariant mass distribution of {pi}&apos;'{+-}{pi}'&apos;0 pairs produced in the process {tau}{yields}{pi}&apos;'{+-}{pi}'&apos;0{nu} . The analysis is based on a sample of 33,096 events collected by the L3 detector between 1991 and 1994. The data is not inconsistent with the hypothesis that the process is being mediated by the p(770) meson alone but is in better agreement with the inclusion of an extra {rho} resonance in the decay of the tau lepton. (Author) 10 refs.

  20. Novel action of apolipoprotein E (ApoE: ApoE isoform specifically inhibits lipid-particle-mediated cholesterol release from neurons

    Directory of Open Access Journals (Sweden)

    Fujita Shinobu C

    2007-05-01

    Full Text Available Abstract Background Since the majority of apolipoprotein E (apoE existing in the cerebrospinal fluid is associated with high-density lipoprotein (HDL, one should focus on the role of the apoE-HDL complex rather than on that of free apoE in cholesterol metabolism in the central nervous system. However, the apoE-isoform-specific effect of apoE-HDL on cholesterol transport remains unclarified. Results Here we show that apoE3-HDL induced a marked cholesterol release from neurons, while apoE4-HDL induced little. To elucidate the mechanism underlying this phenomenon, we used a complex of lipid emulsion (EM with recombinant apoE3 or apoE4 (apoE-EM at various apoE concentrations. When a small number of apoE molecules were associated with EM, apoE3- and apoE4-EM, induced a marked cholesterol release to a level similar to that induced by EM alone. However, when apoE at given concentrations was incubated with EM, apoE3-EM induced a marked cholesterol release, while apoE4-EM induced little. Under these conditions, a greater number of apoE4 molecules were associated with EM than apoE3 molecules. When an increasing number of apoE molecules were associated with EM, both apoE3-EM and apoE4-EM induced little cholesterol release. Preincubation with β-mercaptoethanol increased the number of apoE3 molecules associated with EM similar to that of apoE4 molecules, indicating that the presence (apoE3 or absence (apoE4 of intermolecular disulfide bond formation is responsible for the association of a greater number of apoE4 molecules to EM than apoE3 molecules. Conclusion These results suggest that although apoE and a lipid particle are lipid acceptors, when apoE and a lipid particle form a complex, apoE on the particle surface inhibits the lipid particle-mediated cholesterol release from cells in an apoE-concentration-dependent manner.

  1. Orbit as a Mirror of Systemic Disease; &apos;&apos; Epidemiologic, Clinical and Imaging &apos;&apos;

    Directory of Open Access Journals (Sweden)

    Aliakbar Ameri

    2009-01-01

    Full Text Available   "n1- Infectious: toxoplasmosis , toxocariasis ,TB , syphilis , leprosy , HIV , CMV. "n2- Non infectous: endocrine, diabetes, thyroid, connective tissue disease &apos;&apos;RA, SLE, wegeners, PAN, systemic sclerosis&apos;&apos;, vasculitides, GCA&apos;&apos;, sarcoidosis, behcet&apos;s disease, vogt koyangi harada syndrome, phakomatoses. "nAll diseases should be demonstrated by clinical images and imaging slides. "n-imaging "nX-RAY, high frequency US and color doppler, 2D and 3D X-RAY CT, MRI: "n1- X-RAY: in fractures, foreign bodies, skull combined anomalies and few other cases. "n2-High-frequency ultrasound for posterior chamber and ciliary body micro-anatomic changes &apos;&apos; tumors granulations&apos;&apos;. "nColor Doppler study for vascular lesions, central retin artery, tumors in the globe and retrobulbar region. "n3- X-RAY CT for tumors, 2D and 3D for fractures, 3D for bone anatomy, foreign body &apos;&apos; modality of choice is 2directional 2D CT scan &apos;&apos;, sino-nasal diseases, CT-angiography or phlebography in large vessel evaluation, DSA for small vessel anatomy. "n4- MRI for tumors and infection also granulation process. "nMRI and MRV in large vessel anatomy, functional – MRI for the visual pathway, tractography. "nConclusion : "nModality of choice : "n1- CT for foreign bodies &apos;&apos; MRI is contra-indicated in the first step specially in metallic fragments &apos;&apos;. CT for micro-calcification &apos;&apos; retinoblastoma &apos;&apos;,CT for fractures. "n2- MRI for tumors, biometry, soft tissue disease and functional imaging. "n3- DSA for vascular disease of the eye. "n4- U.S for biometery, posterior Chamber, iris and ciliary body lesions. 5- Fluorescein angiography for the retina.  

  2. A &apos;'Toolbox'&apos;21 Equivalent Process for Safety Analysis Software

    Energy Technology Data Exchange (ETDEWEB)

    O' KULA, KR

    2004-04-30

    Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 2002-1 (Quality Assurance for Safety-Related Software) identified a number of quality assurance issues on the use of software in Department of Energy (DOE) facilities for analyzing hazards, and designing and operating controls that prevent or mitigate potential accidents. The development and maintenance of a collection, or &apos;'toolbox,'&apos; of multiple-site use, standard solution, Software Quality Assurance (SQA)-compliant safety software is one of the major improvements identified in the associated DOE Implementation Plan (IP). The DOE safety analysis toolbox will contain a set of appropriately quality-assured, configuration-controlled, safety analysis codes, recognized for DOE-broad, safety basis applications. Currently, six widely applied safety analysis computer codes have been designated for toolbox consideration. While the toolbox concept considerably reduces SQA burdens among DOE users of these codes, many users of unique, single-purpose, or single-site software may still have sufficient technical justification to continue use of their computer code of choice, but are thwarted by the multiple-site condition on toolbox candidate software. The process discussed here provides a roadmap for an equivalency argument, i.e., establishing satisfactory SQA credentials for single-site software that can be deemed &apos;'toolbox-equivalent'&apos;. The process is based on the model established to meet IP Commitment 4.2.1.2: Establish SQA criteria for the safety analysis &apos;'toolbox'&apos; codes. Implementing criteria that establish the set of prescriptive SQA requirements are based on implementation plan/procedures from the Savannah River Site, also incorporating aspects of those from the Waste Isolation Pilot Plant (SNL component) and the Yucca Mountain Project. The major requirements are met with evidence of a software quality assurance plan, software requirements and

  3. &apos;'Beaded'&apos; osteoid osteoma: a possible transition between solitary and multicentric tumor

    Energy Technology Data Exchange (ETDEWEB)

    Chiou, Yi-You [Department of Radiology, Taipei Veterans General Hospital, 201 Sec. 2 Shih-Pai Road, 11217, Taipei (Taiwan); Rosenthal, Daniel I. [Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 (United States); Rosenberg, Andrew E. [Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 (United States)

    2003-07-01

    An extremely rare example of an elongated (3 cm) osteoid osteoma is presented. The tumor demonstrated three focal enlargements connected by narrow areas, suggesting a &apos;&apos;string of beads&apos;&apos; in appearance. The elongated shape suggested the possibility that lesional tissue was stretched in a longitudinal fashion as a result of the rapid skeletal growth. The tumor closest to the growth plate was densely ossified, while the furthest lesion was almost completely lytic, suggesting that the tumor enlarged in a centripetal direction. This case is believed to illustrate a continuum from solitary to multicentric osteoid osteoma. The tumor was treated successfully with three separate percutaneous radiofrequency ablations during a single session. (orig.)

  4. Radmap: &apos;'as-built'&apos; cad models incorporating geometrical, radiological and material information

    Energy Technology Data Exchange (ETDEWEB)

    Piotrowski, L. [Electricite de France (EDF/DRD), 78 - Chatou (France); Lubawy, J.L. [Electricite de France (EDF/CNEPE), 37 - Tours (France)

    2001-07-01

    EDF intends to achieve successful and cost-effective dismantling of its obsolete nuclear plants. To reach this goal, EDF is currently extending its &apos;'as-built'&apos; 3-D modelling system to also include the location and characteristics of gamma sources in the geometrical models of its nuclear installations. The resulting system (called RADMAP) is a complete CAD chain covering 3-D and gamma data acquisitions, CAD modelling and exploitation of the final model. Its aim is to describe completely the geometrical and radiological state of a particular nuclear environment. This paper presents an overall view of RADMAP. The technical and functional characteristics of each element of the chain are indicated and illustrated using real (EDF) environments/applications. (author)

  5. APOE Genotyping, Cardiovascular Disease

    Science.gov (United States)

    ... Home Visit Global Sites Search Help? APOE Genotyping, Cardiovascular Disease Share this page: Was this page helpful? Also ... of choice to decrease the risk of developing cardiovascular disease (CVD) . However, there is a wide variability in ...

  6. Major disruption of D&apos;&apos; beneath Alaska: D&apos;&apos; Beneath Alaska

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Daoyuan [Laboratory of Seismology and Physics of Earth' s Interior, School of Earth and Space Sciences, University of Science and Technology of China, Hefei Anhui China; National Geophysics Observatory at Mengcheng, Anhui China; Helmberger, Don [Seismological Laboratory, California Institute of Technology, Caltech, Pasadena California USA; Miller, Meghan S. [Department of Earth Sciences, University of Southern California, Los Angeles California USA; Jackson, Jennifer M. [Seismological Laboratory, California Institute of Technology, Caltech, Pasadena California USA

    2016-05-01

    D&apos;&apos; represents one of the most dramatic thermal and compositional layers within our planet. In particular, global tomographic models display relatively fast patches at the base of the mantle along the circum-Pacific which are generally attributed to slab debris. Such distinct patches interact with the bridgmanite (Br) to post-bridgmanite (PBr) phase boundary to generate particularly strong heterogeneity at their edges. Most seismic observations for the D&apos;&apos; come from the lower mantle S wave triplication (Scd). Here we exploit the USArray waveform data to examine one of these sharp transitions in structure beneath Alaska. From west to east beneath Alaska, we observed three different characteristics in D&apos;&apos;: (1) the western region with a strong Scd, requiring a sharp δVs = 2.5% increase; (2) the middle region with no clear Scd phases, indicating a lack of D&apos;&apos; (or thin Br-PBr layer); and (3) the eastern region with strong Scd phase, requiring a gradient increase in δVs. To explain such strong lateral variation in the velocity structure, chemical variations must be involved. We suggest that the western region represents relatively normal mantle. In contrast, the eastern region is influenced by a relic slab that has subducted down to the lowermost mantle. In the middle region, we infer an upwelling structure that disrupts the Br-PBr phase boundary. Such an interpretation is based upon a distinct pattern of travel time delays, waveform distortions, and amplitude patterns that reveal a circular-shaped anomaly about 5° across which can be modeled synthetically as a plume-like structure rising about 400 km high with a shear velocity reduction of ~5%, similar to geodynamic modeling predictions of upwellings.

  7. THE FIRST &apos;&apos;WATER FOUNTAIN&apos;&apos; COLLIMATED OUTFLOW IN A PLANETARY NEBULA

    Energy Technology Data Exchange (ETDEWEB)

    Gómez, José F.; Miranda, Luis F.; Guerrero, Martín A. [Instituto de Astrofísica de Andalucía, CSIC, Glorieta de la Astronomía s/n, E-18008 Granada (Spain); Suárez, Olga; Bendjoya, Philippe; Lagadec, Eric [Laboratoire Lagrange, UMR 7293, Université de Nice Sophia-Antipolis, CNRS, Observatoire de la Côte d' Azur, F-06304 Nice (France); Rizzo, J. Ricardo; García-García, Enrique [Centro de Astrobiología (INTA-CSIC), Ctra. M-108, km. 4, E-28850 Torrejón de Ardoz (Spain); Green, James A. [CSIRO Astronomy and Space Science, Australia Telescope National Facility, P.O. Box 76, Epping, NSW 1710 (Australia); Uscanga, Lucero [Institute of Astronomy, Astrophysics, Space Applications and Remote Sensing, National Observatory of Athens, 15236 Athens (Greece); Ramos-Larios, Gerardo [Instituto de Astronomía y Meteorología, Av. Vallarta No. 2602, Col. Arcos Vallarta, C.P. 44130 Guadalajara, Jalisco (Mexico)

    2015-02-01

    &apos;&apos;Water fountains&apos;&apos; (WFs) are evolved objects showing high-velocity, collimated jets traced by water maser emission. Most of them are in the post-asymptotic giant branch (post-AGB) and they may represent one of the first manifestations of collimated mass loss in evolved stars. We present water maser, carbon monoxide, and mid-infrared spectroscopic data (obtained with the Australia Telescope Compact Array, Herschel Space Observatory, and the Very Large Telescope, respectively) toward IRAS 15103–5754, a possible planetary nebula (PN) with WF characteristics. Carbon monoxide observations show that IRAS 15103–5754 is an evolved object, while the mid-IR spectrum displays unambiguous [Ne II] emission, indicating that photoionization has started and thus, its nature as a PN is confirmed. Water maser spectra show several components spreading over a large velocity range (≅ 75 km s{sup –1}) and tracing a collimated jet. This indicates that the object is a WF, the first WF known that has already entered the PN phase. However, the spatial and kinematical distribution of the maser emission in this object are significantly different from those in other WFs. Moreover, the velocity distribution of the maser emission shows a &apos;'Hubble-like'&apos; flow (higher velocities at larger distances from the central star), consistent with a short-lived, explosive mass-loss event. This velocity pattern is not seen in other WFs (which are presumably in earlier evolutionary stages). We therefore suggest that we are witnessing a fundamental change of mass-loss processes in WFs, with water masers being pumped by steady jets in post-AGB stars, but tracing explosive/ballistic events as the object enters the PN phase.

  8. Trends in Energy. &apos;The consumer decides&apos;; Trends in Energy. &apos;De consument bepaalt&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Brzezowsky-Ruys, Y.; Van der Zalm, M.; Van Zutphen, M. (eds.)

    2012-03-15

    A report is given of the Capgemini organised congress &apos;Trends in Energy 2011&apos; which has the Dutch subtitle &apos;De consument bepaalt&apos; (The consumer decides&apos;. The focus of the articles, interviews, debates and presentations is on the role of the consumer in the supply of and demand for energy. Parts of the report are in Dutch and English [Dutch] Dit rapport bestaat uit een verslag van het congres &apos;Trends in Energy 2011. De consument bepaalt&apos; en een aantal artikelen met achtergrondinformatie over onder meer de rol van de consument in vraag en aanbod van energie.

  9. Solid state laser technology for inertial confinement fusion: A collection of articles from &apos;&apos;Energy and Technology Review&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    1988-06-01

    This paper contains reprinted articles that record several milestones in laser research at LLNL. &apos;&apos;Neodymium-Glass Laser Research and Development at LLNL&apos;&apos; recounts the history of the Laser Program and our work on neodymium-glass lasers. &apos;&apos;Nova Laser Technology&apos;&apos; describes the capabilities of the Nova laser and some of its uses. &apos;&apos;Building Nova: Industry Relations and Technology Transfer&apos;&apos; illustrates the Laboratory&apos;s commitment to work with US industry in technology development. &apos;&apos;Managing the Nova Laser Project&apos;&apos; details the organization and close monitoring of costs and schedules during the construction of the Nova laser facility. The article &apos;&apos;Optical Coatings by the Sol-Gel Process,&apos;&apos; describes our chemical process for making the damage-resistant, antireflective silica coatings used on the Nova laser glass. The technical challenges in designing and fabricating the KDP crystal arrays used to convert the light wave frequency of the Nova lasers are reported in &apos;&apos;Frequency Conversion of the Nova Laser.&apos;&apos; Two articles, &apos;&apos;Eliminating Platinum Inclusions in Laser Glass&apos;&apos; and &apos;&apos;Detecting Microscopic Inclusions in Optical Glass,&apos;&apos; describe how we dealt with the problem of damaging metal inclusions in the Nova laser glass. The last article reprinted here, &apos;&apos;Auxilliary Target Chamber for Nova,&apos;&apos; discusses the diversion of two of Nova&apos;s ten beamlines into a secondary chamber for the purpose of increasing our capacity for experimentation.

  10. Switzerland as Europe&apos;s &apos;'battery'&apos;. Wishful dream or reality?; Die Schweiz als &apos;&apos;Batterie Europas&apos;&apos;. Utopie oder Realitaet?

    Energy Technology Data Exchange (ETDEWEB)

    Kammer, Adrian; Zurmuehle, Damian; Salzmann, Michael; Baumgartner, Raphael; Mignone, Domenico [Bernische Kraftwerke (BKW), Bern (Switzerland). Energiewirtschaftliche Planung und Prognose

    2015-04-15

    There are plans for Swiss pumped hydrostorage systems to absorb large quantities of excess electricity from European wind and solar power generation. Model-based analyses have shown however that &apos;'Europe&apos;s battery&apos;&apos;, as Switzerland would like to see itself, will not be needed until the middle of this century. Even if all extension projects currently in progress should be completed, Switzerland will not have sufficient pump capacity or import capacity to absorb large amounts of excess electricity. Furthermore, the primary means of making storage capacity available for import electricity would be to reduce reservoir power plant capacity. In view of all this Switzerland&apos;s hopes for a role as a major European electricity storage provider appear somewhat exaggerated even in the long-term perspective.

  11. Aspectos psicossociais na era dos novos tratamentos da AIDS

    Directory of Open Access Journals (Sweden)

    Eduardo Augusto Remor

    Full Text Available O presente artigo descreve o impacto no bem-estar (ansiedade e depressão e qualidade de vida das pessoas HIV+ quando o tratamento anti-retroviral não apresenta os resultados esperados. Foram avaliadas, através de questionários, as percepções e expectativas com o tratamento anti-retroviral, o nível de ansiedade e depressão, o nível de apoio social e a qualidade de vida percebida em 80 pacientes HIV+ em atendimento em um hospital universitário. Os resultados indicaram que as percepções e expectativas negativas com o tratamento podem modular o estado emocional e impactar negativamente a qualidade de vida das pessoas HIV+; e que um nível de apoio social adequado é capaz de atenuar este impacto negativo.

  12. ApoE isoform-dependent changes in hippocampal synaptic function

    Directory of Open Access Journals (Sweden)

    Sullivan Patrick M

    2009-05-01

    Full Text Available Abstract The lipoprotein receptor system in the hippocampus is intimately involved in the modulation of synaptic transmission and plasticity. The association of specific apoE isoform expression with human neurodegenerative disorders has focused attention on the role of these apoE isoforms in lipoprotein receptor-dependent synaptic modulation. In the present study, we used the apoE2, apoE3 and apoE4 targeted replacement (TR mice along with recombinant human apoE isoforms to determine the role of apoE isoforms in hippocampus area CA1 synaptic function. While synaptic transmission is unaffected by apoE isoform, long-term potentiation (LTP is significantly enhanced in apoE4 TR mice versus apoE2 TR mice. ApoE isoform-dependent differences in LTP induction require NMDA-receptor function, and apoE isoform expression alters activation of both ERK and JNK signal transduction. Acute application of specific apoE isoforms also alters LTP induction while decreasing NMDA-receptor mediated field potentials. Furthermore, acute apoE isoform application does not have the same effects on ERK and JNK activation. These findings demonstrate specific, isoform-dependent effects of human apoE isoforms on adult hippocampus synaptic plasticity and highlight mechanistic differences between chronic apoE isoform expression and acute apoE isoform exposure.

  13. &apos;&apos;Black Bone&apos;&apos; MRI: a potential alternative to CT with three-dimensional reconstruction of the craniofacial skeleton in the diagnosis of craniosynostosis

    Energy Technology Data Exchange (ETDEWEB)

    Eley, Karen A. [University of Oxford, John Radcliffe Hospital, Nuffield Department of Surgical Sciences, Oxford (United Kingdom); University of Cambridge, Addenbrookes Hospital, Department of Radiology, Cambridge (United Kingdom); Watt-Smith, Stephen R. [University of Oxford, John Radcliffe Hospital, Nuffield Department of Surgical Sciences, Oxford (United Kingdom); University College London, Eastman Dental Institute, London (United Kingdom); Sheerin, Fintan [University of Oxford, John Radcliffe Hospital, Nuffield Department of Surgical Sciences, Oxford (United Kingdom); Oxford University Hospitals NHS Trust, Oxford (United Kingdom); Golding, Stephen J. [University of Oxford, John Radcliffe Hospital, Nuffield Department of Surgical Sciences, Oxford (United Kingdom)

    2014-10-15

    To determine the potential of novel gradient echo parameters, &apos;&apos;Black Bone&apos;&apos; MRI as an alternative to CT in the identification of normal and prematurely fused cranial sutures both in 2D and 3D imaging. Thirteen children with a clinical diagnosis of craniosynostosis underwent &apos;&apos;Black Bone&apos;&apos; MRI in addition to routine cranial CT. &apos;&apos;Black Bone&apos;&apos; datasets were compared to CT and clinical findings. &apos;&apos;Black Bone&apos;&apos; imaging was subsequently used to develop 3D reformats of the craniofacial skeleton to enhance further visualisation of the cranial sutures. Patent cranial sutures were consistently identified on &apos;&apos;Black Bone&apos;&apos; MRI as areas of increased signal intensity. In children with craniosynostosis the affected suture was absent, whilst the remaining patent sutures could be visualised, consistent with CT and clinical findings. Segmentation of the &apos;&apos;Black Bone&apos;&apos; MRI datasets was successful with both threshold and volume rendering techniques. The cranial sutures, where patent, could be visualised throughout their path. Patent cranial sutures appear as areas of increased signal intensity on &apos;&apos;Black Bone&apos;&apos; MRI distinct from the cranial bone, demonstrating considerable clinical potential as a non-ionising alternative to CT in the diagnosis of craniosynostosis. (orig.)

  14. Response of &apos;Nagpur&apos; mandarin, &apos;Mosambi&apos; sweet orange and &apos;Kagzi&apos; acid lime to gamma radiation

    Energy Technology Data Exchange (ETDEWEB)

    Ladaniya, M.S. E-mail: mslngp@nagpur.dot.net.in; Singh, Shyam; Wadhawan, A.K

    2003-07-01

    The effects of irradiation dose and refrigerated storage conditions on &apos;Nagpur&apos; mandarin (Citrus reticulata Blanco), &apos;Mosambi&apos; sweet orange (Citrus sinensis Osbeck) and &apos;Kagzi&apos; acid lime (Citrus aurantifolia Swingle) were investigated. Mature fruits of these three species were treated with 0, 0.25, 0.5, 1 and 1.5 kGy radiation. &apos;Nagpur&apos; mandarin and &apos;Mosambi&apos; sweet oranges were stored at 6-7 deg. C and 90-95% r.h. for 75 and 90 days, respectively, while &apos;Kagzi&apos; acid limes were stored at 8{+-}1 deg. C and 90-95% r.h. for 90 days. Physico-chemical parameters, sensory attributes and respiration rate were measured besides losses and disorders. In &apos;Nagpur&apos; mandarin, radiation dose upto 1.5 kGy did not cause any rind disorder. Radiation treatments did not reduce the extent of decay. Penicillium rot was delayed in fruit treated with 1.5 kGy, while it appeared early in 0 kGy. Irradiation doses were ineffective to control rots due to Botryodiplodia theobromae and Alternaria citri. Doses upto 1.5 kGy did not cause any significant effect on fruit firmness and juice content; however, total soluble solids increased, while titratable acidity and vitamin &apos;C&apos; content decreased. Texture and flavour scores as recorded after a week, were not affected by irradiation except in 1.5 kGy. In &apos;Mosambi&apos; sweet orange, radiation treatments caused peel disorder in the form of brown sunken areas after 90 days and reduced fruit firmness, acidity and vitamin C content. The TSS content was higher in treated fruit. Flavour and texture were not affected by the doses of irradiation used. In treated acid limes (mature yellow), weight loss and decay were higher than untreated fruit (0 kGy) although difference was non-significant. Juice, TSS, titratable acidity and vitamin C contents were significantly less in treated fruit than in 0 kGy. Texture and flavour scores were also less in treated fruit than in 0 kGy. The

  15. Tratamento da anemia ferropriva com ferro por via oral

    Directory of Open Access Journals (Sweden)

    Rodolfo D. Cançado

    Full Text Available A anemia ferropriva permanece como uma das deficiências nutricionais mais frequentes e importantes no mundo. O tratamento com ferro deve ser iniciado preferencialmente por via oral e a investigação apropriada de sua causa é obrigatória. Os autores discutem os compostos com ferro atualmente disponíveis, o perfil de eficácia, segurança e tolerabilidade desses medicamentos, e o plano terapêutico mais adequado possível para o sucesso no tratamento dessa doença tão comum e importante.

  16. Atelectasias em pediatria: mecanismos, diagnóstico e tratamento

    OpenAIRE

    Johnston,Cíntia; Carvalho, Werther Brunow de

    2008-01-01

    OBJETIVO: Realizar uma revisão da literatura sobre os mecanismos, diagnóstico e tratamento das atelectasias pulmonares em pediatria. MÉTODOS:Efetuou-se uma pesquisa nos bancos de dados eletrônicos Medline e Scielo com os critérios de inclusão: artigos publicados entre os anos de 1960 e 2007, que abordassem a etiologia, fisiopatologia, conseqüências funcionais, avaliação, prevenção, tratamento e complicações das atelectasias pulmonares em pediatria. Palavras-chave: atelectasis, children, pedia...

  17. Tratamento fungicida e qualidade de sementes de mamona

    OpenAIRE

    Nilce Naomi Kobori

    2011-01-01

    O crescente interesse pelo uso de combustíveis renováveis nos últimos anos fez com que culturas oleaginosas, como a mamona, se tornassem importante objeto de estudo. No entanto, para a instalação de campos desta cultura, é imprescindível sementes de boa qualidade. Como não existem defensivos químicos registrados para a ricinocultura, avaliou-se o efeito de tratamentos fungicidas no tratamento de sementes de mamona (Ricinus communis L.), com produtos fungicidas recomendados para sementes de ou...

  18. Tendinopatia patelar: resultados tardios do tratamento cirúrgico

    OpenAIRE

    Marcos Henrique Frauendorf Cenni; Thiago Daniel Macedo Silva; Bruno Fajardo do Nascimento; Rodrigo Cristiano de Andrade; Lúcio Flávio Biondi Pinheiro Júnior; Oscar Pinheiro Nicolai

    2015-01-01

    resumo Objetivo: Avaliar os resultados tardios do tratamento cirúrgico na tendinopatia patelar (TP) com o uso do escore Visa (Victorian Institute of Sport Tendon Study Group) e o método de Verheyden. Métodos: Estudo retrospectivo que avaliou os resultados pós-operatórios de 12 pacientes, ou 14 joelhos, entre julho de 2002 e fevereiro de 2011. Foram incluídos os pacientes com tendinopatia patelar refratários ao tratamento conservador e que não apresentavam outras lesões cirúrgicas concomitan...

  19. ApoE and Quality of Life in Nonagenarians

    Science.gov (United States)

    Parsaik, Ajay K; Lapid, Maria I.; Rummans, Teresa A.; Cha, Ruth H.; Boeve, Bradley F.; Pankratz, Vernon (Shane) S.; Tangalos, Eric G.; Petersen, Ronald C.

    2012-01-01

    Objectives ApoE ε4 is associated with adverse health conditions that negatively impact the quality of life (QOL). The relationship between ApoE ε4 and QOL has not been explored in the oldest old. Our study aimed to examine ApoE in the oldest old, and explore its association with QOL. Design Cross-sectional cohort study. Setting A medium sized community in Olmsted County, Minnesota, USA. Participants 90–99 year old individuals living independently or in long term care environments. Measurements We collected demographic information and measured cognitive function (Short Test of Mental Status [STMS], Mini-Mental State Examination [MMSE], Mattis Dementia Rating Scale [DRS]), QOL (Linear Analogue Self Assessment [LASA]) and ApoE distribution. Subjects were classified as cognitively normal, mild cognitive impairment (MCI), dementia (DEM), or dementia with stroke and/or parkinsonism (DEMSP). Regression model was used to assess the predictors of QOL. Results 121 subjects (45 cognitively normal, 13 MCI, 34 DEM, 29 DEMSP) aged 90–99,106 (87.6 %) females, were included. Frequency of ApoE ε3 allele was highest [194 (80.2%): ε2/3 18, ε3/3 77, ε3/4 22] followed by ApoE ε4 [25 (10.3%): ε2/4 3, ε3/4 22] and ApoE ε2 [23 (9.5%; ε2/2 1, ε2/3 18, ε2/4 3]. None of the subjects carried ApoE ε4/4 genotype. QOL was similar between ApoE ε4 carrier and non-carriers. Physical well-being, emotional well-being, intellectual well-being, social connectedness and coping ability were positively associated with QOL, whereas male gender, DEMSP, pain frequency and pain severity were negatively associated. Conclusions The most common ApoE in the oldest old was ε3/3 genotype and ε3 allele. No association was found between ApoE ε4 and QOL. However, those with high physical, emotional and intellectual well being, social connectedness and coping ability had the highest overall QOL. PMID:22863665

  20. Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis.

    Science.gov (United States)

    Zhu, Li; Zhong, Minghao; Elder, Gregory A; Sano, Mary; Holtzman, David M; Gandy, Sam; Cardozo, Christopher; Haroutunian, Vahram; Robakis, Nikolaos K; Cai, Dongming

    2015-09-22

    The apolipoprotein E4 (ApoE4) allele is the strongest genetic risk factor for developing sporadic Alzheimer's disease (AD). However, the mechanisms underlying the pathogenic nature of ApoE4 are not well understood. In this study, we have found that ApoE proteins are critical determinants of brain phospholipid homeostasis and that the ApoE4 isoform is dysfunctional in this process. We have found that the levels of phosphoinositol biphosphate (PIP2) are reduced in postmortem human brain tissues of ApoE4 carriers, in the brains of ApoE4 knock-in (KI) mice, and in primary neurons expressing ApoE4 alleles compared with those levels in ApoE3 counterparts. These changes are secondary to increased expression of a PIP2-degrading enzyme, the phosphoinositol phosphatase synaptojanin 1 (synj1), in ApoE4 carriers. Genetic reduction of synj1 in ApoE4 KI mouse models restores PIP2 levels and, more important, rescues AD-related cognitive deficits in these mice. Further studies indicate that ApoE4 behaves similar to ApoE null conditions, which fails to degrade synj1 mRNA efficiently, unlike ApoE3 does. These data suggest a loss of function of ApoE4 genotype. Together, our data uncover a previously unidentified mechanism that links ApoE4-induced phospholipid changes to the pathogenic nature of ApoE4 in AD.

  1. OBJECTIVE BAYESIAN ANALYSIS OF &apos;'ON/OFF'&apos; MEASUREMENTS

    Energy Technology Data Exchange (ETDEWEB)

    Casadei, Diego, E-mail: diego.casadei@fhnw.ch [Visiting Scientist, Department of Physics and Astronomy, UCL, Gower Street, London WC1E 6BT (United Kingdom)

    2015-01-01

    In high-energy astrophysics, it is common practice to account for the background overlaid with counts from the source of interest with the help of auxiliary measurements carried out by pointing off-source. In this &apos;'on/off'&apos; measurement, one knows the number of photons detected while pointing toward the source, the number of photons collected while pointing away from the source, and how to estimate the background counts in the source region from the flux observed in the auxiliary measurements. For very faint sources, the number of photons detected is so low that the approximations that hold asymptotically are not valid. On the other hand, an analytical solution exists for the Bayesian statistical inference, which is valid at low and high counts. Here we illustrate the objective Bayesian solution based on the reference posterior and compare the result with the approach very recently proposed by Knoetig, and discuss its most delicate points. In addition, we propose to compute the significance of the excess with respect to the background-only expectation with a method that is able to account for any uncertainty on the background and is valid for any photon count. This method is compared to the widely used significance formula by Li and Ma, which is based on asymptotic properties.

  2. Formation and characterisation of solution processed &apos;'pseudo-bilayer'&apos; organic solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Heinemann, Marc Daniel; Ananthanarayanan, Krishnamoorthy; Thummalakunta, L.N.S.A.; Yong, Chian Haw; Luther, Joachim [Singapore National Univ. (SG). Solar Energy Research Inst. of Singapore (SERIS)

    2011-07-01

    The current state of the art solution processed organic photovoltaic (OPV) cells are based on the bulk heterojunction (BHJ) architecture, consisting of an active layer, in which the donor and the acceptor material are dissolved in a common solvent. In this report, we show that by sequential processing of the active components and by subsequent annealing a &apos;'pseudo-bilayer'&apos; can be formed which results in an enhanced nanomorphology for efficient charge generation and extraction. The enhanced nanomorphology arises from the inter-diffusion of the PCBM nanoparticles into a layer of pre-organised polymer P3HT instead of a phase separation that happens at the time of spin-coating and annealing in the case of conventional BHJ devices. To get a further insight into the inter-diffusion process, TOF-SIMS depth profiling and XPS measurements were carried out for different thermal annealing treatments of these pseudo-bilayer devices, which show full inter-diffusion after only seconds of annealing at 140 C. The optimised photovoltaic devices that were fabricated showed an efficiency of 4.1%. (orig.)

  3. &apos;&apos;1/f noise&apos;&apos; in music: Music from 1/f noise

    Energy Technology Data Exchange (ETDEWEB)

    Voss, R.F.; Clarke, J.

    1978-01-01

    The spectral density of fluctuations in the audio power of many musical selections and of English speech varies approximately as 1/f (f is the frequency) down to a frequency of 5 x 10/sup -4/ Hz. This result implies that the audio-power fluctuations are correlated over all times in the same manner as &apos;&apos;1/f noise&apos;&apos; in electronic components. The frequency fluctuations of music also have a 1/f spectral density at frequencies down to the inverse of the length of the piece of music. The frequency fluctuations of English speech have a quite different behavior, with a single characteristic time of about 0.1 s, the average length of a syllable. The observations on music suggest that 1/f noise is a good choice for stochastic composition. Compositions in which the frequency and duration of each note were determined by 1/f noise sources sounded pleasing. Those generated by white-noise sources sounded too random, while those generated by 1/f/sup 2/ noise sounded too correlated.

  4. Tratamento da endometriose Treatment of endometriosis

    Directory of Open Access Journals (Sweden)

    Paula Andrea de Albuquerque Salles Navarro

    2006-10-01

    Full Text Available Apesar da grande heterogeneidade das manifestações clínicas relacionadas à endometriose, observa-se a sua elevada prevalência em mulheres inférteis e portadoras de dor pélvica crônica. O impacto sócio-econômico desta afecção enigmática é elevado e os dados relacionados à eficácia das diferentes abordagens terapêuticas descritas são bastante conflitantes. Assim, os objetivos do presente artigo são apresentar as evidências científicas disponíveis acerca das diferentes modalidades terapêuticas aplicáveis e estabelecer recomendações para o tratamento da infertilidade e da dor pélvica crônica relacionadas à endometriose. Em pacientes com endometriose mínima ou leve a supressão da função ovariana não é efetiva para melhorar a fertilidade, mas a ablação das lesões associadas à adesiólise parece ser mais efetiva do que a realização exclusiva da laparoscopia diagnóstica. Não há evidências suficientes para determinar se a excisão cirúrgica em casos de doença moderada ou severa melhoraria as taxas de gestação. A fertilização in vitro parece ser uma abordagem adequada, especialmente nos casos de coexistência de fatores de infertilidade e/ou falha de outras abordagens terapêuticas. Deve-se avaliar a possibilidade de usar agonistas do GnRH por 3 a 6 meses, previamente à realização de fertilização in vitro. Em relação ao alívio da dor, verifica-se que a supressão da função ovariana por 3 a 6 meses em pacientes com doença confirmada laparoscopicamente reduz a dor associada à endometriose. Todas as medicações estudadas parecem apresentar eficácia similar, embora os efeitos adversos e de os custos sejam diferentes. A ablação das lesões endometrióticas reduz a dor associada à endometriose, sendo menos efetiva nos casos de doença mínima. A exérese de endometriomas com diâmetro > 4 cm parece melhorar a taxa de fecundidade natural e após procedimentos de reprodução assistida, além de

  5. Study and designing of the &apos;'caliprax'&apos; measurement bench; Etude et realisation du banc &apos;'caliprax'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Barriere, J.Ch

    2001-09-01

    Probing the matter in order to check its elementary constituents, that is the goal of the particle physic. In this field, the experiments consist in colliding highly energetic particle beams and observing the new born particles. These observations are based on big particle detectors whose running is dependant on the precise knowledge of their geometry (position of the detection chambers). To achieve this, the detectors are equipped with alignment sensors, which have to be calibrated before. This document describes the study and the making of a calibration bench for the &apos;Praxial&apos; (PRoximity AXIAL) type sensors, and other works related to these sensors. In a first part, we determine and apply a method to set the tools used to fix the sensor stands on the detection chambers. These settings are made with the use of a tridimensional measuring machine. Then, we study the stands themselves. These investigations concern mechanics: positioning quality of the sensors in their stands, bending of the supports due to the tightening. In this part too, the studies are in the field of dimensional metrology. After this, the works are reoriented toward the bench, with the choice of the displacement sensors among two different technologies: optical, with the Rasnik system, and mechanical, with linear probes as LVDT (Linear Variable Differential Transformer). Following the discovery of an ambiguity on the Rasnik system, we go on the tests to understand its behaviour. We introduce the theory of the alignment sensors calibration, which is based on a minimization calculation. The computer programs are explained in a chapter, and in an other, the implementation of the quality assurance procedures. An other part describes the mechanical studies and the problems they cause. Because of a delay onset of the project, we make a model of the bench. This dummy allows us to test every single function of the final bench. With this device, we record manually the first calibration data and

  6. Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models.

    Science.gov (United States)

    Huang, Yadong

    2011-08-01

    ApoE4 (apolipoprotein E4) is the major known genetic risk factor for AD (Alzheimer's disease). In most clinical studies, apoE4 carriers account for 65-80% of all AD cases, highlighting the importance of apoE4 in AD pathogenesis. Emerging data suggest that apoE4, with its multiple cellular origins and multiple structural and biophysical properties, contributes to AD in multiple ways either independently or in combination with other factors, such as Aβ (amyloid β-peptide) and tau. Many apoE mouse models have been established to study the mechanisms underlying the pathogenic actions of apoE4. These include transgenic mice expressing different apoE isoforms in neurons or astrocytes, those expressing neurotoxic apoE4 fragments in neurons and human apoE isoform knock-in mice. Since apoE is expressed in different types of cells, including astrocytes and neurons, and in brains under diverse physiological and/or pathophysiological conditions, these apoE mouse models provide unique tools to study the cellular source-dependent roles of apoE isoforms in neurobiology and in the pathogenesis of AD. They also provide useful tools for discovery and development of drugs targeting apoE4's detrimental effects.

  7. Proceedings of the DGMK-conference &apos;Synthesis gas chemistry&apos;. Authors&apos; manuscripts

    Energy Technology Data Exchange (ETDEWEB)

    Hoenicke, D.; Kohlpaintner, C.; Luecke, B.; Reschetilowski, W. [eds.

    2000-07-01

    The main topics of the DGMK-Conference &apos;&apos;Synthesis Gas Chemistry&apos;&apos; were: production of synthesis gas from several educts, new catalysts, Fischer-Tropsch synthesis, hydroformylation, steam reforming and carbonylation.

  8. VALORES DO RNI DE PACIENTES SUBMETIDOS AO TRATAMENTO COM ANTICOAGULANTES

    Directory of Open Access Journals (Sweden)

    Simone Aparecida Matos de SOUZA

    2015-12-01

    Full Text Available Uma pesquisa exploratória de natureza qualitativa e quantitativa foi realizada durante o período de maio a agosto de 2013 no Laboratório de Análises Clínicas do Hospital das Clínicas localizado no município de Itaperuna, RJ. O objetivo foi analisar o perfil dos pacientes sob tratamento com anticoagulantes, demonstrando as potenciais variações nos valores da Relação Normalizada Internacional (RNI em comparação aos valores de referência bem como a frequência de realização de tais exames. Um questionário foi aplicado pouco antes da coleta do sangue, estabelecendo-se como critério de inclusão o uso de medicamentos anticoagulantes. Os resultados indicaram um total de 45 pacientes sob tratamento com anticoagulantes, sendo 32 do sexo feminino e 13 do sexo masculino. A maioria dos pacientes encontrava-se sob tratamento com o anticoagulante de uso oral varfarina e se encontrava com idade superior a 50 anos. O valor médio do RNI apresentou-se dentro dos limites considerados seguros, porém mais da metade dos pacientes apresentou RNI < 2,0 e a maioria dos pacientes sob tratamento com anticoagulantes não realiza a avaliação do RNI com frequência.

  9. Tratamento focal e perifocal contra Aëdes aegypti

    Directory of Open Access Journals (Sweden)

    Milton Moura Lima

    1987-06-01

    Full Text Available Em quatro bairros da cidade do Rio de Janeiro, foram feitos ensaios de tratamento focal com abate granulado a 1 ppm e perifocal com pó molhável de Sumition a 2,5%. Esses tratamentos foram feitos tanto isoladamente quanto em conjunto e, também, associados à aplicação de inseticida a ultrabaixo volume. Os índices prediais, levantados um mês depois de terminado o trabalho, mostraram que o tratamento focal dispensa qualquer medida auxiliar. O tratamento perifocal mostrou-se inócuo e incapaz de impedir o aparecimento de larvas de Aëdes aegypti e de outros insetos, em pneus pintados, na face externa, com Sumition e com Malation.In four districts of the city of Rio dc Janeiro focal treatment essays with granulated Abate at 1 ppm and perifocal treatment essays with wettable powder of Sumithion at 2,5% were performed. These were made either alone or in combination as well as associated to insecticides applied at ultra low volume. The premise indices obtained one month after the treatments indicates that the focal treatment alone is effective, no other addicional methods being necessary. The perifocal treatment is not effective and did not prevent the development of Aedes aegypti larvae and other insects in tires which had their external surface painted with Sumithion and Malathion.

  10. Absorption-line &apos;'forest'&apos; in quasar spectra, and the structure of the universe

    Energy Technology Data Exchange (ETDEWEB)

    Doroshkevich, A.G.; Muket, J.P.

    1985-05-01

    The &apos;'forest'&apos; of absorption lines observed in the spectrum of distant quasars is interpreted in light of the adiabatic (pancake) theory for the origin and evolution of structure in the universe. The hidden mass might reside in neutrino-like particles (perhaps unstable) having a rest mass of about 60--100 eV. Opportunities for testing the hypothesis observationally are discussed.

  11. Magnetic fluctuations can contribute to plasma transport, &apos;&apos;self-consistency constraints&apos;&apos; notwithstanding

    Energy Technology Data Exchange (ETDEWEB)

    Krommes, J.A.; Kim, Chang-Bae

    1987-09-01

    The recent conclusion that in a turbulent, collisionless plasma &apos;&apos;magnetic transport including quasilinear magnetic flutter transport ... does not contribute to the relaxation of (f), and thus is not responsible for electron energy or momentum transport&apos;&apos; is shown to be incorrect for a variety of situations of physical interest, including saturation by quasilinear plateau formation, induced scattering, and, most importantly, conventional mode coupling. The well-established theory of the mean infinitesimal response function and the spectral balance equation provides a unifying framework for understanding the above conclusion. In particular, the cancellations which lead to their conclusion are special cases of well-known relationships between the response function, particle propagator, and dielectric function. A more general, concise, and manifestly gauge-invariant algebraic derivation of the cancellations is given. Though the cancellations occur in a certain limit, these conclusions do not follow in general: The picture of steady-state turbulence as consisting of small-scale &apos;'incoherent'&apos; ballistic &apos;'clumps'&apos; shielded by long-wavelength &apos;'coherent'&apos; dielectric response is physically misleading and mathematically incomplete, as it ignores or mistreates the often dominant process of renormalized n-wave coupling. Thus, when ion nonlinearities are considered, formulas for the magnetic contribution to transport emerge which are quite similar to the quasilinear one. Furthermore, limits are possible in which all or part of the noise can be negligible, yet in which the total fluctuation spectrum remains finite. 56 refs.

  12. In vivo imaging of &apos;'neuroinflammation'&apos;. Principles and applications; In-vivo-Darstellung &apos;'neuroinflammatorischer'&apos; Veraenderungen mit [{sup 11}C] PK11195-PET. Grundlagen und Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Gerhard, A.; Banati, R.B. [MRC Clinical Sciences Centre and Div. of Neuroscience, Faculty of Medicine, Imperial Coll., London (United Kingdom)

    2002-09-01

    Microglia are the brains&apos; resident immunocompetent cells that can be activated by acute as well as chronic pathological stimuli. When activated they express the peripheral benzodiazepine binding site to which the isoquinolin PK11195 binds with high specificity. Labelled with [{sup 11}C], the R-enatiomer [{sup 11}C] PK1195 has been used for positron emission tomography (PET) studies to demonstrate neuroinflammatory changes in vivo. [{sup 11}C](R) PK11195-PET has been successfully used to show in vivo microglial activation in ischemic (stroke), inflammatory (multiple sclerosis) and degenerative (Alzheimer&apos;s and Parkinson&apos;s disease). Longitudinal studies are in progress to help to clarify the relationship between localisation and extent of microglial activation and the clinical presentations in these disorders. This will help to determine the role of [{sup 11}C](R) PK11195 PET as a diagnostic tool and a surrogate marker of &apos;'neuroinflammation'&apos; in therapeutic trials. (orig.) [German] Mikroglia sind residente immunkompetente Zellen des Gehirns, die durch akute, aber auch langsam voranschreitende, chronische Schaedigungprozesse aktiviert werden. Im aktivierten Zustand exprimieren sie den peripheren Benzodiazepinrezeptor, an den das Isoquinolin PK11195 spezifisch bindet. Radioaktiv markiert kann das R-Enantiomer [{sup 11}C] PK11195 als Ligand in der Positronenemissionstomographie (PET) genutzt werden und ermoeglicht so die In-vivo-Darstellung aktiver &apos;'neuroinflammatorischer'&apos;, d.h. die Mikroglia aktivierender, Veraenderungen. Mit der [{sup 11}C](R) PK11195-PET konnte bisher In-vivo-Mikrogliaaktivierung bei ischaemischen (Schlaganfall), entzuendlichen (multiple Sklerose) und degenerativen (Morbus Alzheimer- und Parkinson-Erkrankung) demonstriert werden. Laufende longitudinale Studien werden dazu beitragen, die Beziehung zwischen Lokalisation und Ausmass der Mikrogliaaktivierung und klinischer Krankheitsauspraegung

  13. Tratamento do transtorno bipolar: eutimia Bipolar disorder treatment: euthymia

    Directory of Open Access Journals (Sweden)

    Fábio Gomes de Matos e Souza

    2005-01-01

    Full Text Available O transtorno bipolar é um quadro complexo caracterizado por episódios de depressão, mania ou hipomania e fases assintomáticas. O tratamento visa ao controle de episódios agudos e prevenção de novos episódios. O tratamento farmacológico iniciou-se com o lítio. Até o momento, o lítio permanece como o tratamento com mais evidências favoráveis na fase de manutenção. Outros tratamentos demonstram eficácia nessa fase, como o valproato, a carbamazepina e os antipsicóticos atípicos. Dos antipsicóticos atípicos o mais estudado nesta fase do tratamento é a olanzapina. Mais estudos prospectivos são necessários para confirmar a ação profilática de novos agentes.Bipolar disorder is a complex disorder characterized by depression episodes, mania or hypomania and asymptomatic phases. The treatment aims at the control of acute episodes and prevention of new episodes. The pharmacological treatment was inaugurated with lithium. Until the moment, lithium remains as the treatment with more favorable evidences in the maintenance phase. Other treatments demonstrate efficacy in this phase, as valproate, carbamazepine and atypical antipsychotics. Of the atypical antipsychotics, the most studied in this phase of treatment is olanzapine. More prospective studies are necessary to confirm prophylactic action of new agents.

  14. Eficacia de las relaciones poligámicas en el orden social: derecho a la pensión de viudedad de varios cónyuges coetáneos del causante

    Directory of Open Access Journals (Sweden)

    MERCEDES SOTO MOYA

    2016-12-01

    Full Text Available This paper analyzes effectiveness of polygamous relationships in the social order, in particular, as regards the right to a widow's pension of several spouses of the deceased. Despite the existence of an opening trend, there is not a sole criterion, so the jurisprudential solutions ranging from not granting the pension until his concession but with different deals. El presente trabajo analiza la eficacia de las relaciones poligámicas en el orden social, en concreto, por lo que respecta al derecho a la pensión de viudedad de varios cónyuges coetáneos del causante. A pesar de la existencia de una tendencia jurisprudencial aperturista, no hay un criterio único, por lo que las soluciones oscilan desde la no concesión de la pensión hasta su concesión pero con diferentes repartos

  15. &apos;&apos;Whither Deterrence?&apos;&apos; A Brief Synopsis May, 2002

    Energy Technology Data Exchange (ETDEWEB)

    Poppe, C; Vergino, E; Barker, R; Brown, P; Gilmartin, T J; Nach, M; Sloss, L

    2002-05-29

    To most audiences, deterrence has been interconnected with nuclear weapons whose purpose had been to deter a Soviet attack. But, the Soviet Union has been gone for almost a decade. President George W. Bush has stated that Russia is not an enemy of the US and the numbers of nuclear weapons can be dramatically reduced. It is important to note that deterrence has always transcended nuclear weapons. The US&apos; first line of deterrence has been its formidable conventional warfare capability, designed to prevent conflict and win wars if necessary. The role of nuclear weapons has been to deter the,use of nuclear weapons and other weapons of mass destruction against U.S. interests during the conduct of conventional warfare and to ensure our ability to inflict massive destruction on any who would use nuclear weapons, or other weapons of mass destruction, against us. With regard to the Soviet Union, the threat of the use of nuclear weapons was a critical component of our deterrent to prevent massive Soviet conventional attack against our allies in Europe. However, the events of September 11, 2001 make clear that we have not convinced all who seek to harm us that we will be able to respond in a manner to make them wish they had not even tried. The September 11 attacks, as well as other past conflicts, do not mean that deterrence has failed-it remains effective against the threats for which it was designed. We have known there are other threats for which we did not have a credible deterrent. The challenge is to sustain deterrence against the classic threats as they evolve in technical sophistication while remaining alert to the need to evaluate continuously our ability to deter previously unforeseen challenges. How then should we be looking at deterrence as we consider fifteen or so years in the future, say to about 2015? What will be the role of nuclear weapons and other instruments of mass destruction in the future? What should the US be doing to prepare for the future? In

  16. &apos;&apos;Whither Deterrence?&apos;&apos; A Brief Synopsis May, 2002

    Energy Technology Data Exchange (ETDEWEB)

    Poppe, C; Vergino, E; Barker, R; Brown, P; Gilmartin, T J; Nach, M; Sloss, L

    2002-05-29

    To most audiences, deterrence has been interconnected with nuclear weapons whose purpose had been to deter a Soviet attack. But, the Soviet Union has been gone for almost a decade. President George W. Bush has stated that Russia is not an enemy of the US and the numbers of nuclear weapons can be dramatically reduced. It is important to note that deterrence has always transcended nuclear weapons. The US&apos; first line of deterrence has been its formidable conventional warfare capability, designed to prevent conflict and win wars if necessary. The role of nuclear weapons has been to deter the,use of nuclear weapons and other weapons of mass destruction against U.S. interests during the conduct of conventional warfare and to ensure our ability to inflict massive destruction on any who would use nuclear weapons, or other weapons of mass destruction, against us. With regard to the Soviet Union, the threat of the use of nuclear weapons was a critical component of our deterrent to prevent massive Soviet conventional attack against our allies in Europe. However, the events of September 11, 2001 make clear that we have not convinced all who seek to harm us that we will be able to respond in a manner to make them wish they had not even tried. The September 11 attacks, as well as other past conflicts, do not mean that deterrence has failed-it remains effective against the threats for which it was designed. We have known there are other threats for which we did not have a credible deterrent. The challenge is to sustain deterrence against the classic threats as they evolve in technical sophistication while remaining alert to the need to evaluate continuously our ability to deter previously unforeseen challenges. How then should we be looking at deterrence as we consider fifteen or so years in the future, say to about 2015? What will be the role of nuclear weapons and other instruments of mass destruction in the future? What should the US be doing to prepare for the future? In

  17. &apos;'Routine'&apos; brain CT in psychiatric patients - does it make sense?; &apos;'Routine'&apos;-Schaedel-CT in der psychiatrischen Diagnostik

    Energy Technology Data Exchange (ETDEWEB)

    Pickuth, D.; Heywang-Koebrunner, S.H.; Spielmann, R.P. [Martin-Luther-Universitaet Halle-Wittenberg, Halle (Germany). Klinik und Poliklinik fuer Diagnostische Radiologie

    1999-11-01

    Purpose: To prospectively assess the spectrum of brain CT findings in psychiatric patients and to determine the number of patients that had an underlying cause for the symptoms. Patients and methods: Over a period of six months, 142 patients (78 males, 64 females; median age 61 [18-91] years) were referred for CT brain scans. Their scans were reviewed, along with the clinical information that was provided in the request form. All the hard copies were reviewed to assess areas of ischaemia, infarction, atrophy, tumours, and haematomas. The majority of requests were to exclude vascular event or space-occupying lesions. Clinical indications included mood disorders (depression, mania), schizophrenic disorders, dementia, personality and behavioural disorders. Results: 31 (22%) were normal. 111 (78%) had varying degrees of ischaemia, infarction and cerebral/cerebellar atrophy. 7 (4.9%) had space-occupying lesions which included two gliomas and five meningiomas. There were two chronic subdural haematomas and one arteriovenous malformation. Conclusion: 1. In our series, pathologic findings in &apos;routine&apos; brain CT&apos;s were encountered in 78%. 2. The incidence of brain tumours was 4.9%, compared with 0.00005% of the general population. 3. CT scanning in psychiatric patients is cost-effective and especially indicated when there is an atypical presentation, or inadequate response to standard treatment. (orig.) [German] Hintergrund: Bei psychiatrischen Patienten wird vielerorts routinemaessig eine kraniale Computertomographie (CCT) durchgefuehrt. Ob der Nutzen die Kosten rechtfertigt, wurde im Rahmen einer Prospektivstudie untersucht. Patienten und Methode: In einem Zeitraum von 6 Monaten wurde bei 142 psychiatrischen Patienten (78 Maenner, 64 Frauen, 18-91 Jahre, Median 61 Jahre) ein CCT angefertigt. Die Untersuchung erfolgt nativ in 5-mm-Schichtdicke, bei klinischem Verdacht auf eine intrakraniale Raumforderung auch kontrastverstaerkt. Ueberweisungsdiagnosen waren v

  18. Sex Differences in Presynaptic Density and Neurogenesis in Middle-Aged ApoE4 and ApoE Knockout Mice

    Directory of Open Access Journals (Sweden)

    A. Rijpma

    2013-01-01

    Full Text Available Atherosclerosis and apolipoprotein E ε4 (APOE4 genotype are risk factors for Alzheimer’s disease (AD and cardiovascular disease (CVD. Sex differences exist in prevalence and manifestation of both diseases. We investigated sex differences respective to aging, focusing on cognitive parameters in apoE4 and apoE knockout (ko mouse models of AD and CVD. Presynaptic density and neurogenesis were investigated immunohistochemically in male and female apoE4, apoE ko, and wild-type mice. Middle-aged female apoE4 mice showed decreased presynaptic density in the inner molecular layer of the dentate gyrus of the hippocampus. Middle-aged female apoE ko mice showed a trend towards increased neurogenesis in the hippocampus compared with wild-type mice. No differences in these parameters could be observed in middle-aged male mice. Specific harmful interactions between apoE4 and estrogen could be responsible for decreased presynaptic density in female apoE4 mice. The trend of increased neurogenesis found in female apoE ko mice supports previous studies suggesting that temporarily increased amount of synaptic contacts and/or neurogenesis is a compensatory mechanism for synaptic failure. To our knowledge, no other studies investigating presynaptic density in aging female apoE4 or apoE ko mice are available. Sex-specific differences between APOE genotypes could account for some sex differences in AD and CVD.

  19. VEGF Mediates ApoE4-Induced Neovascularization and Synaptic Pathology in the Choroid and Retina.

    Science.gov (United States)

    Antes, Ran; Salomon-Zimri, Shiran; Beck, Susanne C; Garcia Garrido, Marina; Livnat, Tami; Maharshak, Idit; Kadar, Tamar; Seeliger, Mathias; Weinberger, Dov; Michaelson, Daniel M

    2015-01-01

    Apolipoprotein E4 (apoE4), the most prevalent genetic risk factor for Alzheimer's disease (AD), is associated with neuronal and vascular impairments. Recent findings suggest that retina of apoE4 mice have synaptic and functional impairments. We presently investigated the effects of apoE4 on retinal and choroidal vasculature and the possible role of VEGF in these effects. There were no histological differences between the retinal and choroidal vasculatures of naïve apoE3 and apoE4 mice. In contrast, laserdriven choroidal injury induced higher levels of choroidal neovascularization (CNV) in apoE4 than in apoE3 mice. These effects were associated with an inflammatory response and with activation of the Muller cells and asrocytic markers gluthatione synthetase and GFAP, all of which were more pronounced in the apoE4 mice. CNV also induced a transient increase in the levels of the synaptic markers synaptophysin and PSD95 which were however similar in the apoE4 and apoE3 naive mice. Retinal and choroidal VEGF and apoE levels were lower in naïve apoE4 than in corresponding apoE3 mice. In contrast, VEGF and apoE levels rose more pronouncedly following laser injury in the apoE4 than in apoE3 mice. Taken together, these findings suggest that the apoE4-induced retinal impairments, under basal conditions, may be related to reduced VEGF levels in the eyes of these mice. The hyper-neovascularization in the apoE4 mice might be driven by increased inflammation and the associated surge in VEGF following injury. Retinal and choroidal VEGF and apoE levels were lower in naïve apoE4 than in corresponding apoE3 mice. In contrast, VEGF and apoE levels rose more pronouncedly following laser injury in the apoE4 than in apoE3 mice. Taken together, these findings suggest that the apoE4-induced retinal impairments, under basal conditions, may be related to reduced VEGF levels in the eyes of these mice. The hyper-neovascularization in the apoE4 mice might be driven by increased inflammation

  20. Report of working committee 3 &apos;&apos;liquefied gases&apos;&apos;; Rapport du comite de travail 3 &apos;&apos;gaz liquefies&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Baudino, M.

    2000-07-01

    Working Committee 3&apos;s report concerns the evolution of the liquefied gas industry: both liquefied natural gas (LNG) and liquefied petroleum gases (LPG). Given the current state of the LNG market the Committee decided to concentrate on this area in particular. A number of aspects have been identified which the Committee has been looking at, while others have been given to Study Groups set up specifically for the purpose. The first aspects regard: - the development of LNG and LPG, new installations, future chains and relevant statistical data; - the role of LNG and LPG in starting up a gas industry; - operating and technological improvements in the LNG industry; - energy savings, cold utilization and reduction of CO{sub 2} emissions. The Study Groups which were set up dealt with the following subjects: Technological and Economical Developments for cost Reduction of LNG/LPG Facilities. Small Scale LNG Projects and Modular Systems. LNG/LPG Peak Shaving and Satellite Plants. LNG versus Pipeline Infrastructure. (author)

  1. The adductor magnus &apos;'mini-hamstring'&apos;: MRI appearance and potential pitfalls

    Energy Technology Data Exchange (ETDEWEB)

    Broski, Stephen M.; Murthy, Naveen S.; Collins, Mark S. [Department of Radiology, Mayo Clinic, Rochester, MN (United States); Krych, Aaron J. [Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN (United States); Obey, Mitchel R. [Mayo School of Graduate Medical Education, Rochester, MN (United States)

    2016-02-15

    To examine the anatomic MRI characteristics of the adductor magnus mini hamstring (AMMH) and explore its involvement in cases of hamstring avulsion. An IRB-approved retrospective review of patients undergoing &apos;&apos;hamstring protocol&apos;&apos; MRI between March 2009 and June 2014 was performed. Two musculoskeletal radiologists recorded multiple AMMH anatomic characteristics and involvement in cases of hamstring avulsion. Seventy-six AMMHs were analyzed in 66 patients [35 females and 31 males, mean age 49.3 ± 15.2 years (range 17-81)]. Eleven percent of AMMHs were poorly visualized, 51 % visualized, and 37 % well visualized. Seven percent demonstrated round, 73 % ovoid, and 21 % flat/lenticular tendon morphologies. Most (88 %) demonstrated typical origins. Average cross-sectional area (CSA) was 22.4 ± 10.6 mm{sup 2} (range 6-56), diameter was 7.2 ± 2.5 mm (range 2.9-15), medial distance from the semimembranosus tendon was 7.5 ± 2.5 mm (range 3-14), and tendon length was 6.8 ± 3.3 cm (range 1.2-14.1). There was no gender difference in AMMH anatomic measurements or correlation between age and CSA or diameter. Of 17 complete hamstring avulsion cases, the AMMH was intact in 13, partially torn in 3, and completely torn in 1. The AMMH is a constant finding with variable anatomic characteristics. It is visualized or well visualized by MRI in 88 % of cases and is a sizable tendon located in close proximity to the semimembranosus tendon. Because it is uncommonly completely torn (6 %) in cases of complete hamstring avulsion, radiologists should be aware of its presence and appearance to avoid diagnostic confusion. (orig.)

  2. &apos;&apos;Atomic Optics&apos;&apos;: Nonimaging Optics on the Nanoscale

    Energy Technology Data Exchange (ETDEWEB)

    Roland Winston Joseph O' Gallagher

    2005-01-15

    This is the final report for a one year close out extension of our basic research program that was established at the University of Chicago more than sixteen years ago to explore and develop the optical sub-discipline that has come to be known as &apos;&apos;nonimaging optics&apos;&apos;. This program has been extremely fruitful, having both broadened the range of formalism available for workers in this field and led to the discovery of many new families of optical devices. These devices and techniques have applications wherever the efficient transport and transformation of light distributions are important, in particular in illumination, fiber optics, collection and concentration of sunlight, and the detection of faint light signals in physics and astrophysics. Over the past thirty years, Nonimaging Optics (Welford and Winston, 1989) has brought a fresh approach to the analysis of many problems in classical macro-scale optics. Through the application of phase-space concepts, statistical methods, thermodynamic arguments, etc., many previously established performance limits were able to be broken and many technical surprises with exciting practical applications were discovered. The most recent three-year phase of our long-term continuing program ended in late 2002 and emphasized extending our work in geometrical optics and expanding it to include some interesting questions in physical optics as well as in the new field of statistical optics. This report presents a survey of the basic history and concepts of nonimaging optics and reviews highlights and significant accomplishments over the past fifteen years. This is followed by a more detailed summary of recent research directions and accomplishments during the last three years. This most recent phase was marked by the broadening in scope to include a separate project involving a collaboration with an industrial partner, Science Applications International Corporation (SAIC). This effort was proposed and approved in

  3. SHORT GAMMA-RAY BURSTS IN THE &apos;'TIME-REVERSAL'&apos; SCENARIO

    Energy Technology Data Exchange (ETDEWEB)

    Ciolfi, Riccardo [Physics Department, University of Trento, Via Sommarive 14, I-38123 Trento (Italy); Siegel, Daniel M., E-mail: riccardo.ciolfi@unitn.it, E-mail: daniel.siegel@aei.mpg.de [Max Planck Institute for Gravitational Physics (Albert Einstein Institute), Am Mühlenberg 1, D-14476 Potsdam-Golm (Germany)

    2015-01-10

    Short gamma-ray bursts (SGRBs) are among the most luminous explosions in the universe and their origin still remains uncertain. Observational evidence favors the association with binary neutron star or neutron star-black hole (NS-BH) binary mergers. Leading models relate SGRBs to a relativistic jet launched by the BH-torus system resulting from the merger. However, recent observations have revealed a large fraction of SGRB events accompanied by X-ray afterglows with durations ∼10{sup 2}-10{sup 5} s, suggesting continuous energy injection from a long-lived central engine, which is incompatible with the short (≲ 1 s) accretion timescale of a BH-torus system. The formation of a supramassive NS, resisting the collapse on much longer spin-down timescales, can explain these afterglow durations, but leaves serious doubts on whether a relativistic jet can be launched at the merger. Here we present a novel scenario accommodating both aspects, where the SGRB is produced after the collapse of a supramassive NS. Early differential rotation and subsequent spin-down emission generate an optically thick environment around the NS consisting of a photon-pair nebula and an outer shell of baryon-loaded ejecta. While the jet easily drills through this environment, spin-down radiation diffuses outward on much longer timescales and accumulates a delay that allows the SGRB to be observed before (part of) the long-lasting X-ray signal. By analyzing diffusion timescales for a wide range of physical parameters, we find delays that can generally reach ∼10{sup 5} s, compatible with observations. The success of this fundamental test makes this &apos;'time-reversal'&apos; scenario an attractive alternative to current SGRB models.

  4. Volatile oil prices: two propositions from economics and &apos;'Realpolitik'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Wirl, F.

    1988-02-01

    This paper attempts to interpret OPEC&apos;s decision making process by analysing the political-economic behaviour of the Member Countries of the Organization of the Petroleum Exporting Countries. The economic objectives of OPEC members is first discussed under the hypothesis of cooperation versus competition. A loose marketing arrangement among OPEC members is then assumed. Both approaches, pure economics and Real-politik lead to the same conclusion: the likelihood of a volatile price increase.

  5. Diabetes gestacional : um algoritmo de tratamento multidisciplinar=Gestational diabetes management: a multidisciplinary treatment algorithm

    OpenAIRE

    Weinert, Letícia Schwerz; Silveiro, Sandra Pinho; Oppermann, Maria Lúcia Rocha; Salazar, Cristiano Caetano; Simionato, Bárbara Marina; Siebeneichler, Aline Stalder; Reichelt, Angela de Azevedo Jacob

    2011-01-01

    O tratamento do diabetes gestacional é importante para evitar a morbimortalidade materno- -fetal. O objetivo deste artigo é descrever o tratamento atualmente disponível para o manejo otimizado da hiperglicemia na gestação e sugerir um algoritmo de tratamento multidisciplinar. A terapia nutricional é a primeira opção de tratamento para as gestantes, e a prática de exercício físico leve a moderado deve ser estimulada na ausência de contraindicações obstétricas. O tratamento medicamentoso está r...

  6. Extracellular proteolysis of apolipoprotein E (apoE by secreted serine neuronal protease.

    Directory of Open Access Journals (Sweden)

    Irfan Y Tamboli

    Full Text Available Under normal conditions, brain apolipoprotein E (apoE is secreted and lipidated by astrocytes, then taken up by neurons via receptor mediated endocytosis. Free apoE is either degraded in intraneuronal lysosomal compartments or released. Here we identified a novel way by which apoE undergoes proteolysis in the extracellular space via a secreted neuronal protease. We show that apoE is cleaved in neuronal conditioned media by a secreted serine protease. This apoE cleavage was inhibited by PMSF and α1-antichymotrypsin, but not neuroserpin-1 or inhibitors of thrombin and cathepsin G, supporting its identity as a chymotrypsin like protease. In addition, apoE incubation with purified chymotrypsin produced a similar pattern of apoE fragments. Analysis of apoE fragments by mass spectrometry showed cleavages occurring at the C-terminal side of apoE tryptophan residues, further supporting our identification of cleavage by chymotrypsin like protease. Hippocampal neurons were more efficient in mediating this apoE cleavage than cortical neurons. Proteolysis of apoE4 generated higher levels of low molecular weight fragments compared to apoE3. Primary glial cultures released an inhibitor of this proteolytic activity. Together, these studies reveal novel mechanism by which apoE can be regulated and therefore could be useful in designing apoE directed AD therapeutic approaches.

  7. The effect of a high-fat diet on brain plasticity, inflammation and cognition in female ApoE4-knockin and ApoE-knockout mice

    NARCIS (Netherlands)

    C.I.F. Janssen (Carola); D. Jansen (Diane); M.P.C. Mutsaers (Martina); J. Dederen (Jos); B. Geenen (Bram); M. Mulder (Monique); A.J. Kiliaan Kiliaan (Amanda J.)

    2016-01-01

    textabstractApolipoprotein E4 (ApoE4), one of three common isoforms of ApoE, is a major risk factor for late-onset Alzheimer disease (AD). ApoE-deficient mice, as well as mice expressing human ApoE4, display impaired learning and memory functions and signs of neurodegeneration. Moreover, ApoE protec

  8. Locality or non-locality in quantum mechanics: hidden variables without &apos;&apos;spooky action-at-a-distance&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Aharonov, Y. [Texas A and M Univ., College Station, TX (United States); South Carolina Univ., Columbia, SC (United States). Dept. of Physics and Astronomy; Tel Aviv Univ. (Israel). School of Physics and Astronomy; Botero, A. [South Carolina Univ., Columbia, SC (United States). Dept. of Physics and Astronomy; Centro Internacional de Fisica, Ciudad Univ., Bogota (Colombia); Scully, M. [Texas A and M Univ., College Station, TX (United States); Max-Planck-Institut fuer Quantenoptik (MPQ), Garching (Germany)

    2001-02-01

    The folklore notion of the &apos;&apos;Non-Locality of Quantum Mechanics&apos;&apos; is examined from the point of view of hidden-variables theories according to Belinfante&apos;s classification in his Survey of Hidden Variables Theories. It is here shown that in the case of EPR, there exist hidden variables theories that successfully reproduce quantum-mechanical predictions, but which are explicitly local. Since such theories do not fall into Belinfante&apos;s classification, we propose an expanded classification which includes similar theories, which we term as theories of the &apos;'third'&apos; kind. Causal implications of such theories are explored. (orig.)

  9. Tratamento do Mieloma Múltiplo recidivado Relapsed Multiple Myeloma treatment

    Directory of Open Access Journals (Sweden)

    Vania T. M. Hungria

    2007-03-01

    Full Text Available O mieloma múltiplo ainda é uma doença incurável. Apesar das novas estratégias de tratamento, a maioria dos pacientes recidiva. O padrão da recidiva é muito heterogêneo, podendo se apresentar com comportamento indolente ou agressivo. O tratamento da doença recidivada depende de vários fatores: do tratamento realizado como primeira linha, se transplante autólogo de medula óssea ou não, da resposta e sua duração, se a recidiva ocorreu com ou sem tratamento de manutenção, do performance status do paciente e da reserva medular. Se a recidiva ocorrer após seis meses do término do tratamento, o mesmo esquema quimioterápico inicial pode ser instituído. O transplante autólogo de medula óssea pode ser proposto como consolidação em recidivas quimiossensíveis ou como tratamento de resgate, se as células-tronco periféricas tiverem sido coletadas anteriormente. A talidomida tem sido utilizada em pacientes com mieloma múltiplo recidivado após quimioterapia convencional ou após o transplante autólogo da medula óssea. A talidomida sozinha pode induzir respostas objetivas em pelo menos 1/3 dos pacientes que já receberam muitos tratamentos; e quando combinada com quimioterapia, as respostas objetivas ocorrem em aproximadamente 2/3 dos pacientes. O bortezomibe está indicado em pacientes recidivados, sozinho ou associado a dexametasona e a outras drogas, com taxas de resposta de 43% a 76%. O melhor tratamento do paciente com mieloma múltiplo recidivado deve ser individualizado, dependendo da idade, da função da medula óssea, da terapia inicial, do padrão e tempo para a recidiva.Multiple myeloma still remains an incurable disease. Despite the new treatment approaches, almost all patients face the risk of an eventual relapse. The pattern of relapse is very heterogeneous and can be indolent or more aggressive. The treatment of relapsed disease depends on a number of factors: duration of response, relapse on or off maintenance

  10. The &apos;Instrumental&apos; Reality of Phlogiston

    Directory of Open Access Journals (Sweden)

    Mi Gyung Kim

    2008-07-01

    Full Text Available The stability of phlogiston in eighteenth-century French chemistry depended not on its role as a comprehensive theory, but on its operational (instrumental, theoretical, and philosophical (speculative identities that were forged in different contexts, yet were interwoven to designate a single substance. It was as &apos;real&apos; as any other chemical substance to the degree that it was obtained through material operations, occupied a place in the theoretical edifice of the affinity table, and was endowed with a corpuscular ontology. Lavoisier labeled it as an &apos;imaginary&apos; substance because it offered a unique resistance to his vision of the new chemistry based on &apos;metric&apos; measurements and algebraic representations.

  11. NDA National Graduate Programme &apos;nucleargraduates&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Dawson, Carl

    2010-07-01

    The aim of this paper is to outline the NDA National Graduate Programme (nuclear graduates). The NDA has a remit under the Energy Act (2004) &apos;to maintain and develop the skills for decommissioning and nuclear clean-up&apos;. Although current research is now being reviewed, there is significant evidence to suggest that the age profile in the Site Licence Companies is skewed towards older workers and there is likely to be a skill shortage in 3-5 years. As nuclear clean-up is a national issue; skill shortages also become a national issue in a very real sense. In addition, evidence suggests that the industry needs to be constantly challenged in order to achieve its targets for decommissioning. The NDA has a unique position under the Act. It is both a strategic overseer and direct employer. To this end the &apos;National Graduate Programme&apos; is aligned to both the NDA&apos;s previous succession plans and the needs of the industry. Industry needs leadership that challenges the status quo and moves the UK nuclear industry to become best in class; Industry needs a dedicated to programme to address skills shortages and difficult to recruit areas such as, but not exclusively, estimators, schedulers, contract managers, site engineers, decommissioning technicians, safety monitors; The NDA has indicated a &apos;commercial and politically savvy&apos; cohort is required to meet its own internal challenges and to ensure sustainability in its own workforce, and to be sensitive to the needs of customers and suppliers alike; Need to create a more diversified workforce in the nuclear industry and also plan for new skills evolving from research and development breakthroughs; Need to ensure that Tier 1, 2, 3 and 4 contractors invest in the leadership and skills for the future. World Class - delivery will be benchmarked against UK based multinational companies who operate in a global graduate attraction and development marketplace. The graduates targeted will be from leading

  12. Why are effective potentials &apos;soft&apos;?

    Energy Technology Data Exchange (ETDEWEB)

    Klapp, Sabine H L; Diestler, Dennis J; Schoen, Martin [Stranski-Laboratorium fuer Physikalische und Theoretische Chemie, Sekretariat TC7, Technische Universitaet Berlin, Strasse des 17 Juni 124, D-10623 Berlin (Germany)

    2004-10-20

    This paper is concerned with effective potentials W{sub 1}(R) between interacting supramolecular particles separated by a distance R. We focus on the question of why these potentials are typically &apos;soft&apos;, i.e., remain finite for R {yields} 0 and vary more weakly with R than the underlying interatomic interaction potentials. On the basis of a general expression linking W{sub 1}(R) to the free energy F of the supramolecular system we investigate the origin of the apparent &apos;softness&apos; of W{sub 1}(R) by considering a number of special model systems, starting with an atom and a diatomic molecule. This simple model already yields a W{sub 1}(R) that is finite at R = 0, but W{sub 1}(R) does not exhibit the slowly varying character typical of effective potentials for realistic systems. We then show that the larger length scale is recovered when one introduces both many-body interactions and thermal fluctuations within the framework of a &apos;toy model&apos;, that is disc-shaped supramolecular units composed of thermalized configurations of Lennard-Jones atoms. In this case, W{sub 1}(R) varies so slowly that it can be parametrized by estimating the free energy change associated with the overlap of the discs. The resulting overlap approximation to W{sub 1}(R) behaves qualitatively like ad hoc effective potentials used in mesoscale simulations, such as dissipative particle dynamics. Indeed, on the basis of Monte Carlo simulations and a solution of hypernetted chain integral equations, we find that fluids interacting via DPD and overlap potentials have very similar structural and thermophysical properties. Moreover, the &apos;overlap&apos; fluid (like other &apos;effective&apos; fluids) turns out to be so &apos;soft&apos; that its properties, particularly at high densities, can be very well estimated by a mean-field treatment.

  13. Efeitos da acupuntura no tratamento da ansiedade: revisao integrativa

    Directory of Open Access Journals (Sweden)

    Sueli Leiko Takamatsu Goyatá

    2016-06-01

    Full Text Available RESUMO Objetivo: avaliar as evidências científicas disponíveis na literatura sobre os efeitos da acupuntura no tratamento da ansiedade e a qualidade desses estudos. Método: revisão integrativa, realizada nas bases/bancos de dados CINAHL, LILACS, PUBMEDPICO, SciELO, The Cochrane Library, no período entre 2001 a 2014. Os descritores anxiety, acupuncture therapy, acupuncture e anxiety disorders foram combinados entre si para garantir a ampla busca de estudos primários. Resultados: dos 514 artigos, 67 foram selecionados para leitura na íntegra e 19 incluídos. Desses, 11 apresentaram forte nível de evidência. Dos seis artigos de estudos clínicos randomizados, cinco apresentaram qualidade classificada como razoável. Dois estudos utilizaram acupunturistas enfermeiros para a aplicação da intervenção. Os resultados mostram efeitos positivos e estatisticamente significativos do uso da acupuntura para tratamento de indivíduos com ansiedade. Conclusão: a acupuntura parece ser um tratamento promissor para a ansiedade, no entanto, há necessidade de melhorar a qualidade metodológica das pesquisas nessa temática.

  14. Tendinopatia patelar: resultados tardios do tratamento cirúrgico

    Directory of Open Access Journals (Sweden)

    Marcos Henrique Frauendorf Cenni

    2015-10-01

    Full Text Available resumo Objetivo: Avaliar os resultados tardios do tratamento cirúrgico na tendinopatia patelar (TP com o uso do escore Visa (Victorian Institute of Sport Tendon Study Group e o método de Verheyden. Métodos: Estudo retrospectivo que avaliou os resultados pós-operatórios de 12 pacientes, ou 14 joelhos, entre julho de 2002 e fevereiro de 2011. Foram incluídos os pacientes com tendinopatia patelar refratários ao tratamento conservador e que não apresentavam outras lesões cirúrgicas concomitantes. Pacientes que não foram devidamente acompanhados no período pós-operatório foram excluídos. Resultados: Pelo método de Verheyden, nove pacientes foram considerados muito bons, dois bons e um ruim. Em relação ao Visa, a média foi de 92,4 pontos, com apenas dois pacientes abaixo de 70 pontos (66 e 55 pontos. Conclusão: O tratamento cirúrgico da tendinopatia patelar, quando corretamente indicado, tem bons resultados em longo prazo.

  15. A ayahuasca e o tratamento da dependência

    Directory of Open Access Journals (Sweden)

    Marcelo S. Mercante

    2013-12-01

    Full Text Available A ayahuasca é uma bebida psicoativa utilizada por diversos grupos indígenas por toda a Amazônia, assim como por xamãs mestiços (chamados "vegetalistas" e por religiões e grupos independentes no Brasil. Desde a década de 1990 esta bebida vem sendo empregada no tratamento da dependência. Existem atualmente alguns centros espalhados pela América do Sul que realizam este tipo de tratamento. Realizei trabalho de campo em quatro deles, um no Peru e três no Brasil. Neste artigo faço uma pequena descrição etnográfica destes centros e teço algumas considerações sobre o papel da experiência durante o efeito do chá no processo de recuperação da dependência e também da possibilidade deste tipo de tratamento não ser uma mera terapia de substituição.

  16. Varios puentes de Berlín

    Directory of Open Access Journals (Sweden)

    Heusel, Hanns

    1963-03-01

    Full Text Available The last war destroyed a large number of civil works, among which were the Berlin bridges. As the number of these was considerable, it was decided to improve on the original designs and methods of construction, taking advantage of new materials and prestressing techniques. Of the 84 reconstructed bridges, 24 of them have been made in prestressed concrete. This emphasizes what considerable importance was attached to this constructional method at a time when this technology had not yet reached its present day mature development. The rebuilt bridges have spans varying between 25 and 100 ms. Their foundations differ considerably in each particular case. Some consist of pile structures, others are of sheet piling, and others again are caissons. At present the most important prestressed bridge in Berlin is the Disching bridge, which runs over the Havel, and carries the road to Spandau. Its single span is 94 ms long, and the ratio of rise to span is 1/63.1.La última guerra mundial destruyó una serie de obras públicas, entre las cuales se hallaban muchos puentes de Berlín. Como el número de puentes destruidos es considerable, se pensó en mejorar las obras originales y los métodos de construcción, para lo cual se contaban con nuevos materiales y la técnica del pretensado, actualmente en estado de madurez. De las 84 obras que se han reconstruido, 24 son de hormigón pretensado. Esto pone de relieve la importancia que se le dio a este sistema en aquellos momentos en que la técnica de este tipo de construcciones no había alcanzado todavía el actual desarrollo. Los puentes reconstruidos tienen luces que varían de 25 a 100 metros. Los cimientos de estas obras son muy distintos y variados: unos están formados por tablestacas, otros se apoyan sobre pilotes y, finalmente, otros, constituidos por cajones. El puente pretensado más importante actualmente en Berlín es el de Disching, que salva el río Havel y cuyo objeto es el de dar paso a la carretera de la región de Spandau. Su único tramo tiene 94 m de luz y una relación entre flecha y luz de 1/63,1.

  17. &apos;&apos;Rueckbau 2014&apos;&apos;. KWS Congress regarding decommissioning and dismantling at Zwentendorf nuclear training power plant; &apos;&apos;Rueckbau 2014&apos;&apos;. KWS-Rueckbau-Fachtagung im Schulungskernkraftwerk Zwentendorf

    Energy Technology Data Exchange (ETDEWEB)

    Maassen, Herbert [KRAFTWERKSSCHULE E.V. (KWS), Essen (Germany)

    2015-06-01

    From September 24 to 25, 2014, KRAFTWERKS-SCHULE E.V. (KWS) held the congress &apos;&apos;Rueckbau 2014&apos;&apos;.This first congress about nuclear power plant decommissioning was combined with an exhibition in the fully equipped Zwentendorf nuclear training power plant. The exhibitors had the opportunity to present and test their products in the ambience of a real nuclear power plant, close to original plant components. The visitors got a general overview of the on-site conditions. During the lectures the process of decommissioning and dismantling of a nuclear power plant were described, problems within this process were discussed, and possible solutions were recommended.

  18. Quantifying the &apos;naturalness&apos; of the curvaton model

    Energy Technology Data Exchange (ETDEWEB)

    Lerner, Rose N. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Helsinki Institute of Physics (Finland); Melville, Scott [Helsinki Institute of Physics (Finland)

    2014-02-15

    We investigate the probability of obtaining an observable curvature perturbation, using as an example the minimal curvaton-Higgs (MCH) model. We determine &apos;probably observable&apos; and &apos;probably excluded&apos; regions of parameter space assuming generic initial conditions and applying a stochastic approach for the curvaton&apos;s evolution during inflation. Inflation is assumed to last longer than the N{sub obs}≅55 observable e-folds, and the total number of e-folds of inflation determines the particular ranges of parameters that are probable. For the MCH model, these &apos;probably observable&apos; regions always lie within the range 8 x 10{sup 4} GeV≤m{sub σ}≤2 x 10{sup 7} GeV, where m{sub σ} is the curvaton mass, and the Hubble scale at horizon exit is chosen as H{sub *}=10{sup 10} GeV. Because the &apos;probably observable&apos; region depends on the total duration of inflation, information on parameters in the Lagrangian from particle physics and from precision CMB observables can therefore provide information about the total duration of inflation, not just the last N{sub obs} e-folds. This method could also be applied to any model that contains additional scalar fields to determine the probability that these scalar fields contribute to the curvature perturbation.

  19. On the &apos;efficiency&apos; of futures markets

    Energy Technology Data Exchange (ETDEWEB)

    Bopp, A.E.; Sitzer, Scott

    1988-07-01

    One definition of market efficiency holds that today&apos;s price of an item contains all the price information that there is about that item. That is, today&apos;s price contains information about peoples&apos; expectations about the future. However, in estimating price equations analysts almost exclusively look to the past in developing price forecasting models. This paper examines the question: how do futures prices affect today&apos;s price for heating oil. That is, do futures markets add to the efficiency of markets by conveying information from the future to the present.

  20. Fatores associados a baixa adesao ao tratamento medicamentoso em idosos

    Directory of Open Access Journals (Sweden)

    Noemia Urruth Leao Tavares

    2013-12-01

    Full Text Available OBJETIVO : Analisar fatores associados à baixa adesão ao tratamento medicamentoso em idosos. MÉTODOS : Estudo transversal de base populacional, com amostra representativa de 1.593 indivíduos com 60 anos ou mais, residentes na região urbana de Bagé, RS, em 2008. A amostragem foi realizada em múltiplos estágios. Os dados foram coletados em entrevistas individuais nos domicílios. Analisou-se a associação entre a baixa adesão referida ao tratamento medicamentoso mensurado pelo Brief Medication Questionnaire (BMQ e fatores demográficos, socioeconômicos, comportamentais e de saúde, assistência e prescrição. Foi utilizado modelo de regressão de Poisson para estimar as razões de prevalência bruta e ajustada, os respectivos intervalos de confiança de 95% e p-valor (teste de Wald. RESULTADOS : Cerca de 78,0% dos indivíduos referiram ter usado algum medicamento nos sete dias precedentes à entrevista. Desses, cerca de 1 / 3 foram considerados com baixa adesão ao tratamento. Os fatores significativamente associados à baixa adesão foram: idade (65 a 74 anos, não ter plano de saúde, ter que comprar (totalmente ou em parte os seus medicamentos, ter três ou mais morbidades, possuir incapacidade instrumental para a vida diária e usar três ou mais medicamentos. CONCLUSÕES : A utilização elevada de medicamentos, decorrente da alta prevalência de doenças crônico-degenerativas em idosos, e o acesso ao tratamento devem ser considerados pelos profissionais de saúde para adoção de estratégias que visem diminuir a baixa adesão ao tratamento, aumentando a resolutividade terapêutica e a qualidade de vida desses pacientes.

  1. O tratamento da doenca renal cronica pode afetar a audicao?

    Directory of Open Access Journals (Sweden)

    Priscila Suman Lopez

    2014-01-01

    Full Text Available Introdução: Doença renal crônica (DRC é definida pela presença de lesão renal levando à perda lenta e progressiva da função renal. Objetivo: Comparar testes auditivos entre pacientes com DRC submetidos a diferentes método de tratamento. Material e método: Estudo clínico transversal. Os grupos foram divididos de acordo com o método de tratamento: hemodiálise (n = 35, diálise peritoneal (n =15, conservador (n = 51 e 27 pacientes saudáveis (controle. Pacientes com idade superior a 60 anos, perda auditiva congênita, síndromes genéticas, infecções de orelha média e transplante renal foram excluídos da pesquisa. A avaliação audiológica incluiu audiometria tonal, emissões otoacústicas evocadas transientes e Potencial Evocado Auditivo de Tronco Encefálico (PEATE; e as variáveis avaliadas foram: sexo, idade, diagnóstico de hipertensão arterial e diabetes, estádio da DRC, tempo de diagnóstico do diabetes e da hipertensão arterial, duração da DRC e do tratamento. Resultados: A idade, presença de hipertensão arterial e tempo de DRC foram estatisticamente significantes e controlados. O grupo conservador apresentou piores limiares auditivos na audiometria tonal e o intervalo III-V do PEATE significativamente maior que o da hemodiálise. Conclusão: O tratamento conservador mostrou piores resultados na avaliação auditiva, independente de diabetes e de hipertensão, reforçando que os pacientes submetidos a tratamento para DRC devem realizar avaliação auditiva completa para melhor compreensão da doença e de seus efeitos sobre o sistema auditivo.

  2. Maintain levels of nicotine but reduce other smoke constituents: a formula for &apos;'less-hazardous'&apos; cigarettes

    Energy Technology Data Exchange (ETDEWEB)

    Robinson, J.C.; Young, J.C.; Rickert, W.S.

    1984-09-01

    Twenty-two volunteers who smoked more than 20 cigarettes with &apos;'high'&apos; nicotine yields (0.8 to 1.2 mg) per day participated in an 8-week study designed to test the hypothesis that smoking cigarettes with a constant level of nicotine but reduced deliveries of tar, carbon monoxide, and hydrogen cyanide leads to a decrease in smoke absorption. All subjects smoked their usual high-nicotine brand for the first 3 weeks (P1), and the absorption of smoke constituents was determined from levels of thiocyanate and cotinine in saliva and serum, levels of carbon monoxide in expired air, and levels of carboxyhemoglobin in the blood. During the final 5 weeks (P2), the treatment group (16 subjects) switched to the &apos;'light'&apos; version of their usual brands (similar yields of nicotine but with reduced yields of tar, carbon monoxide, and hydrogen cyanide); the control group (6 subjects) smoked their usual brands for the duration of the study. Average levels of cotinine for the subjects who switched during P2 were not significantly different from those of the control group as was expected. Slight reductions were noted in average expired-air carbon monoxide levels, blood carboxyhemoglobin, and saliva thiocyanate, but these reductions were smaller than anticipated based on brand characteristics. The results suggest that the ratio of smoke constituents is different when individuals, rather than machines, smoke cigarettes. Yields determined under subject-defined conditions are necessary in order to properly evaluate the role of nicotine in the design of &apos;'less-hazardous'&apos; cigarettes.

  3. Development of an underground system for transporting people at the enterprise &apos;&apos;Bespremskiye ugolnyye shakhty&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Frei, J.; Horvath, M.; Vago, J.

    1983-01-01

    An examination is made of the stages of development, and advantages are characterized of the mechanized system for transporting people at mines. A technical-economic comparison was made of the possible way to solve the transport problems (variants for the use of cable of winding of the cars, locomotive thrust, belt conveyer transport, freight transport, suspension seats, inclined tracts). Technical characteristics are presented for the thrust devices, cars, loading and unloading stations, and also different equipment used at the Hungarian enterprise &apos;&apos;Bespremskiye ugolnyye shakhty&apos;&apos;.

  4. The effect of prior deformation on the foaming behavior of &apos;'FORMGRIP'&apos; precursor material

    Energy Technology Data Exchange (ETDEWEB)

    Frei, J.; Mortensen, A. [Institute of Materials, Ecole Polytechnique Federale de Lausanne, Lausanne, CH-1015 (Switzerland); Gergely, V.; Clyne, T.W. [Department of Materials Science, University of Cambridge, Pembroke Street, Cambridge CB2 3QZ (United Kingdom)

    2002-10-01

    It is shown that extrusion of &apos;'FORMGRIP'&apos; precursor material prior to baking leads to accelerated foaming and finer, more uniform cell structures. This effect is correlated with microstructural observations made on the precursor materials and on the foams. It is thought that, while extrusion apparently does not extensively fracture the gas-generating hydride particles, it does induce some damage to their protective surface oxide layers. Removal of the porosity normally present in as-cast precursors may also be beneficial. (Abstract Copyright [2002], Wiley Periodicals, Inc.)

  5. Electrolyzed-water generator &apos;SaniBoy&apos;; Eisei jokinsuik kyokyu sochi &apos;SaniBoy&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Inoue, M.; Kakiuchi, H.; Muto, K. [Fuji Electric Co. Ltd., Tokyo (Japan)

    2000-03-10

    In the food industry, injuries due to food poisoning have been increasing. Especially the mass outbreak of food poisoning by Escherichia coli such as O-157 in 1996 gave warning on the importance of food sanitation management. Public efforts such as the Hazard Analysis and Critical Control Point (HACCP) system have been made to prevent food poisoning. Recently, disinfection made by electrolyzing water with some salt added has attracted attention. Fuji Electric has developed the generator &apos;SaniBoy&apos; that produces weak alkaline electrolyzed water without wasting water. The environment-friendly &apos;SaniBoy&apos; will contribute to sanitation in various fields. (author)

  6. Macrophage-specific apoE gene repair reduces diet-induced hyperlipidemia and atherosclerosis in hypomorphic Apoe mice.

    Directory of Open Access Journals (Sweden)

    Nathalie Gaudreault

    Full Text Available BACKGROUND: Apolipoprotein (apo E is best known for its ability to lower plasma cholesterol and protect against atherosclerosis. Although the liver is the major source of plasma apoE, extra-hepatic sources of apoE, including from macrophages, account for up to 10% of plasma apoE levels. This study examined the contribution of macrophage-derived apoE expression levels in diet-induced hyperlipidemia and atherosclerosis. METHODOLOGY/PRINCIPAL FINDINGS: Hypomorphic apoE (Apoe(h/h mice expressing wildtype mouse apoE at ∼2-5% of physiological levels in all tissues were derived by gene targeting in embryonic stem cells. Cre-mediated gene repair of the Apoe(h/h allele in Apoe(h/hLysM-Cre mice raised apoE expression levels by 26 fold in freshly isolated peritoneal macrophages, restoring it to 37% of levels seen in wildtype mice. Chow-fed Apoe(h/hLysM-Cre and Apoe(h/h mice displayed similar plasma apoE and cholesterol levels (55.53±2.90 mg/dl versus 62.70±2.77 mg/dl, n = 12. When fed a high-cholesterol diet (HCD for 16 weeks, Apoe(h/hLysM-Cre mice displayed a 3-fold increase in plasma apoE and a concomitant 32% decrease in plasma cholesterol when compared to Apoe(h/h mice (602.20±22.30 mg/dl versus 888.80±24.99 mg/dl, n = 7. On HCD, Apoe(h/hLysM-Cre mice showed increased apoE immunoreactivity in lesional macrophages and liver-associated Kupffer cells but not hepatocytes. In addition, Apoe(h/hLysM-Cre mice developed 35% less atherosclerotic lesions in the aortic root than Apoe(h/h mice (167×10(3±16×10(3 µm(2 versus 259×10(3±56×10(3 µm(2, n = 7. This difference in atherosclerosis lesions size was proportional to the observed reduction in plasma cholesterol. CONCLUSIONS/SIGNIFICANCE: Macrophage-derived apoE raises plasma apoE levels in response to diet-induced hyperlipidemia and by such reduces atherosclerosis proportionally to the extent to which it lowers plasma cholesterol levels.

  7. An Anti-apoE4 Specific Monoclonal Antibody Counteracts the Pathological Effects of apoE4 In Vivo.

    Science.gov (United States)

    Luz, Ishai; Liraz, Ori; Michaelson, Daniel M

    2016-06-02

    ApolipoproteinE4 (apoE4) is the most prevalent genetic risk factor for Alzheimer's disease (AD) and as such is a promising therapeutic target. This study examined the extent to which the pathological effects of apoE4 can be counteracted in vivo utilizing an immunological approach in which anti-apoE4 antibodies are applied peripherally by i.p. injections into apoE4-targeted replacement mice. Prerequisites for the successful pursuit of this objective are the availability of antibodies that specifically bind brain apoE4 and not apoE3, and demonstrating that direct application of these antibodies into the brain can counteract the effects of apoE4. Accordingly, it was shown that the antiapoE4 monoclonal antibody (mAb) 9D11 binds specifically to brain apoE4 and not apoE3. Direct i.c.v. application of mAb 9D11 prevented the apoE4-driven accumulation of Aβ in hippocampal neurons following activation of the amyloid cascade by inhibiting the Aβ-degrading enzyme neprilysin. These findings provide a proof-of-concept that anti-apoE4 mAb 9D11, when introduced into the brain, can counteract the apoE4 effects in vivo. Subsequent experiments, utilizing repeated i.p. injections of mAb 9D11, resulted in the formation of apoE/IgG complexes specifically in apoE4 mice. This was associated with reversal of the cognitive impairments of apoE4 in the Morris water maze and the novel object recognition test as well as with reversal of key apoE4-driven pathologies including the hyperphosphorylated tau and the reduced levels of the apoER2 receptor. These results indicate that anti-apoE4 immunotherapy counteracts the cognitive and brain pathological effects of apoE4, and suggest that such an approach could also benefit human apoE4 carriers.

  8. Technology &apos;90

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    The US Department of Energy (DOE) laboratories have a long history of excellence in performing research and development in a number of areas, including the basic sciences, applied-energy technology, and weapons-related technology. Although technology transfer has always been an element of DOE and laboratory activities, it has received increasing emphasis in recent years as US industrial competitiveness has eroded and efforts have increased to better utilize the research and development resources the laboratories provide. This document, Technology &apos;90, is the latest in a series that is intended to communicate some of the many opportunities available for US industry and universities to work with the DOE and its laboratories in the vital activity of improving technology transfer to meet national needs. Technology &apos;90 is divided into three sections: Overview, Technologies, and Laboratories. The Overview section describes the activities and accomplishments of the DOE research and development program offices. The Technologies section provides descriptions of new technologies developed at the DOE laboratories. The Laboratories section presents information on the missions, programs, and facilities of each laboratory, along with a name and telephone number of a technology transfer contact for additional information. Separate papers were prepared for appropriate sections of this report.

  9. Comment on &apos;&apos;Teleportation of two-mode squeezed states&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    He Guangqiang; Zhang Jingtao [State Key Lab of Advanced Optical Communication Systems and Networks Department of Electronic Engineering, Shanghai Jiaotong University, Shanghai 200030 (China)

    2011-10-15

    We investigate the teleportation scheme of two-mode squeezed states proposed by Adhikari et al.[S. Adhikari et al., Phys. Rev. A 77, 012337 (2008)]. It uses four-mode entangled states to teleport two-mode squeezed states. The fidelity between the original two-mode squeezed states and teleported ones is calculated. The maximal fidelity value of Adhikari&apos;s protocol is 0.38, which is incompatible with the fidelity definition with the maximal value 1. In our opinion, one reason is that they calculate the fidelity for multimodes Gaussian states using the fidelity formula for single-mode ones. Another reason is that the covariance matrix of output states should be what is obtained after applying the linear unitary Bogoliubov operations (two cascaded Fourier transformations) on the covariance matrix given in Eq. (12) in their paper. These two reasons result in the incomparable results. In addition, Adhikari&apos;s protocol can be simplified to be easily implemented.

  10. Radiobiological study of the radioprotective activity of a natural Iranian compound, &apos;'Shir-Khecht'&apos;; Etude radiobiologique de l&apos;activite radioprotectrice d&apos;un compose naturel Iranien: le &apos;'Shir-Khecht'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Rouhanizadeh, N. [Commissariat a l' Energie Atomique, 92 - Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1968-01-01

    After reviewing the primary mechanisms of the action of ionizing radiation, the possible mechanisms of the action of radioprotective substances, the various chemical structures having a protective effect and the methods for studying chemical radioprotection, the author presents the results he has obtained with natural Iranian product: &apos;'Shir-Khecht'&apos;. Tests with this product at lethal and sublethal doses have been carried out on the rat using various means of introduction. The effect of radiation, both with and without protection, has been studied using histological and biochemical methods. The product examined has, in effect, a protective action; it is, furthermore, non-toxic and active when taken orally. (author) [French] Apres avoir rappele les mecanismes primaires de l&apos;action des rayonnements ionisants, les mecanismes possibles de l&apos;action des substances radioprotectrices, les diverses structures chimiques possedant un effet protecteur et les methodes d&apos;etude de la radioprotection chimique, l&apos;auteur presente les resultats qu&apos;il a obtenus en utilisant un compose naturel iranien: le &apos;'Shir-Khecht'&apos;. Des essais de ce produit, chez le rat, par diverses voies d&apos;introduction, a dose letale et subletale ont ete effectues. L&apos;effet des radiations, avec et sans protection, a ete etudie a l&apos;aide de methodes histologiques et biochimiques. Le compose essaye possede un pouvoir protecteur; il est, de plus, non toxique et actif par voie orale. (auteur)

  11. Development and utilization of a mechanical barrier for large-calibre cavern necks. The &apos;&apos;Spider Plug&apos;&apos;; Entwicklung und Einsatz einer mechanischen Absperrung fuer grosskalibrige Kavernenhaelse. Der &apos;&apos;Spider Plug&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Pfeifer, K.; Maut, D. [UGS GmbH, Mittenwalde (Germany)

    2013-08-01

    An hydraulic separation of a well and the cavern can be necessary for different workover applications, e.g. casing milling or underreaming. The separation is needed to ensure a mud circulation during such operations. In that case a barrier is set after flooding the cavern, which will then be used as a mechanical abutment for the cement bridge. If the diameter of the cavern neck has been enlarged due to e.g. unwanted leaching processes or unstabilized underreaming processes, it might get impossible to set a standard plug with the available technologies into those diameters. Therefore UGS GmbH has developed a mechanical plug, which is set hydraulically. The so called &apos;Spider Plug&apos; is used as basis for a cement bridge and can be removed by drilling after the workover has been done. Depending on the dimension of the setting tool a cavern neck up to 50&apos;&apos; diameter can be plugged by the &apos;Spider Plug&apos;. Up to now a number of successful operations on different locations has shown, that the &apos;Spider Plug&apos; is a practicable and cost-efficient solution for a mechanical abutment of large cavern necks. (orig.)

  12. Finding the object&apos;&apos; proceedings addendum

    Energy Technology Data Exchange (ETDEWEB)

    Whiting, M.A.; Devaney, D.M.

    1990-10-01

    The purpose of this workshop was to discuss finding the object -- that is, how software engineers imagine, invent, design, or recycle objects and their behaviors for object-oriented software engineering. The workshop organizers (and, as we subsequently discovered, several of the workshop participants) felt that this issue is crucial to successful object-oriented software engineering (after all, finding objects is what the projects is all about, isn&apos;t it ). Unfortunately, when previous workshops have had the opportunity to review and discuss techniques practitioners use to find objects, too often the results were heated debates on what is an object &apos;&apos; which becomes all consuming. We believed that, given appropriate control over the question of which kind of object&apos;&apos; is being discussed (which meant tell us what object you are trying to find, then tell us your method), a workshop to concentrate on techniques for finding objects would be quite appropriate. 8 refs., 2 figs.

  13. The Mixed-Proficiency Language Class: Consequences for Students, Professors and the Institution (La clase de varios niveles. Consecuencias para los estudiantes, los profesores y para la institución

    Directory of Open Access Journals (Sweden)

    Lenna Barrantes Elizondo

    2014-11-01

    Full Text Available This article examines the effects of a mixed-proficiency language class on the participation, progress, retention and classroom management with students enrolled in the Associate Program in English at Universidad Nacional (Brunca Campus. The social and economic consequences that this phenomenon may have on the university and the community are also analyzed. Data were collected using focus groups, interviews, questionnaires, structured observations and artifacts. Se examinan los efectos de reunir estudiantes con varios niveles lingüísticos en una sola clase de inglés como lengua extranjera y sus efectos en la participación, progreso, retención y el desarrollo de la clase en el Diplomado en Inglés de la Universidad Nacional, Sede Regional Brunca. Se analizan las consecuencias sociales y económicas en la institución y en la comunidad. La información se recolectó de grupos focales, entrevistas, cuestionarios, observaciones estructuradas y artefactos.

  14. Determinación de índices reales de consumo de combustible en el laboreo de un fluvisol en la Empresa de Cultivos Varios "Paquito Rosales Benítez"

    Directory of Open Access Journals (Sweden)

    Hugo Berto Vázquez Milanés

    2012-01-01

    Full Text Available El trabajo fue realizado en la Unidad Básica de Producción Cooperativa "El Palmar" perteneciente a la Empresa de Cultivos Varios "Paquito Rosales Benítez" del municipio de Yara, provincia de Granma. La investigación se llevó a cabo en el período de abril del 2007 a enero del 2008, el método utilizado fue el analítico investigativo. Se evaluaron los conjuntos máquina tractor que intervienen en la realización de labores preparación de suelos para el cultivo de raíces y tubérculos. Se realizaron 30 observaciones para cada uno de los conjuntos, evaluando el consumo de combustible. Se determinaron los índices reales de consumo de combustible por conjuntos y labores en un fluvisol. El menor consumo de combustible (14,9 L ha-1 se obtiene para la labor de rotura con el conjunto formado por el tractor T-150 K y el Subsolador Bayamo Modificado.

  15. El Partido Comunista Colombiano, desde su fundación y orientación hacia la "transformación Bolchevique". Varios episodios de la historia de relaciones entre Moscú y el comunismo colombiano

    Directory of Open Access Journals (Sweden)

    Lázar Jeifets

    2010-08-01

    Full Text Available Centenares de libros y miles de artículos han sido escritos sobre la historia de la III Internacional; no obstante en ella existen lagunas y varios enigmas. Una de las causas primordiales de este hecho es la confrontación ideológica acerca sobre la actividad del "partido comunista mundial". Porque mientras los adversarios del movimiento comunista intentaban comprobar que la actividad de las secciones nacionales de la Comintern fue dirigida siempre desde Moscú y que los partidos comunistas nunca fueron organismos independientes, los comunistas por su parte insistían en la originalidad de sus partidos y buscaban la manera de ocultar un tema muy importante, es decir, el carácter de las relaciones entre sus partidos y el Estado Mayor de la Comintern en Moscú. Ambas corrientes adversarias, al mismo tiempo basaban sus postulados sobre "las conjeturas y suposiciones" sin tener la posibilidad de comprobar sus teorías con documentos, como lo ha escrito francamente el historiador R. Alexander en su obra fundamental "Comunismo en Latinoamérica".

  16. The energy and monetary implications of the &apos;24/7&apos; &apos;always on&apos; society

    Energy Technology Data Exchange (ETDEWEB)

    Loveday, Dennis L. [Department of Civil and Building Engineering, Loughborough University, Loughborough, Leicestershire LE11 3TU (United Kingdom)], E-mail: d.l.loveday@lboro.ac.uk; Bhamra, T.; Tang, T. [Department of Design and Technology, Loughborough University, Loughborough, Leicestershire LE11 3TU (United Kingdom); Haines, V.J.A. [Ergonomics and Safety Research Institute (ESRI), Loughborough University, Loughborough, Leicestershire LE11 3TU (United Kingdom); Holmes, M.J. [ARUP, 13, Fitzroy Street, London W1T 4BR (United Kingdom); Green, R.J. [Institute for Energy Research and Policy, University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom)

    2008-12-15

    This paper reviews the trends in society, technology and energy demand of the past 30 years, together with the growth of the &apos;on-demand&apos; culture. The &apos;24/7&apos; or &apos;always on&apos; society can be defined as one where people demand-and generally receive-what they want &apos;now&apos;. It has grown up in parallel with developments in information technology, which have produced the services needed to meet that demand. Larger numbers of appliances, resulting from greater affluence and disposable income, have increased energy use, despite energy efficiencies in other areas. While monetary factors suggest that changes brought about by the 24/7 society will generally be self-correcting at the macro-economic level, there will nevertheless be effects for individuals, such as potentially severe impacts on the fuel poor as electricity prices rise. We conclude with a view of future directions. As the 24/7 culture continues to grow, there is scope for designers and for information technology to manage and reduce energy consumption. This includes buildings, their services systems, and the mix of new technologies that will be deployed over the next 20 years or so, including the possibilities for data exchange and control at the interface between energy suppliers and consumers, coupled with greater understanding of the behaviour of the consumers themselves.

  17. Deleuze&apos;s Children

    Science.gov (United States)

    Hickey-Moody, Anna Catherine

    2013-01-01

    Children, the image of the child, and the gendered figures of the girl and the boy are thematics that run through the work of Deleuze and feature prominently in his joint writing with Guattari. However, there are many different children in Deleuze&apos;s writings. Various child figures do distinct things in Deleuze&apos;s work. In this article, I…

  18. &apos;&apos;Dural tail&apos;&apos; adjacent to acoustic neuroma on MRI: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Lunardi, P. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy)); Mastronardi, L. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy)); Nardacci, B. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy)); Acqui, M. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy)); Fortuna, A. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy))

    1993-04-01

    A &apos;dural tail&apos; on Gd-DTPA-enhanced MRI has been often observed adjacent to meningiomas and considered to be useful in distinguishing meningioma of the cerebellopontine angle from acoustic neuroma. However, demonstration of a dural tail adjacent to an acoustic neuroma indicates that this sign is not specific. (orig.)

  19. Void effects and the determination of &apos;'patches'&apos; for radiation distribution in heterogeneous multilayer shields

    Energy Technology Data Exchange (ETDEWEB)

    Sayedahmed, F.M.; Makarious, A.S.; Kansouh, W.A. (Atomic Energy Authority, Cairo (Egypt). Reactor and Neutron Physics Dept.)

    1989-01-01

    The effect on radiation distribution in heterogeneous multilayer shield configurations containing cylindrical air-filled voids of different diameters have been investigated. The heterogeneous shield assemblies were placed in front of one of the horizontal channels of the ET-RR-1 reactor. The measurements of {delta}-rays and slow neutrons were carried out using LiF-7 and LiF-6 Teflon disc dosimeters, respectively. It was found that the presence of air-filled voids increases the radiation along and perpendicular to the void axis. An empirical formula has been derived to calculate the radiation distribution in the multilayer shields and a good agreement between the measured and calculated values was obtained. The formulae developed by Chase have been checked experimentally to determine the minimum amount of &apos;'patching'&apos; required on the outside of the voided shields to maintain a uniform emergent radiation distribution on the outer surface of the shielding assembly. The applicability of this formula has been defined and a semi-empirical formula developed to describe the experimental results obtained for the required &apos;'patching'&apos;. (author).

  20. Possibilities for a sustainable development. Muligheter for en baerekraftig utvikling; Analyser paa &apos;&apos;World Model&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Bjerkholt, O.; Johnsen, T.; Thonstad, K.

    1993-01-01

    This report is the final report of a project that the Central Bureau of Statistics of Norway has carried out. The report present analyses of the relations between economic development, energy consumption and emission of pollutants to air in a global perspective. The analyses are based on the &apos;&apos;World Model&apos;&apos;, that has been developed at the Institute for Economic Analysis at New York University. The analyses show that it will be very difficult to obtain a global stabilization of the CO[sub 2] emission on the 1990 level. In the reference scenario of the United Nations report &apos;&apos;Our Common Future&apos;&apos;, the increase of CO[sub 2] emissions from 1990 to 2020 was 73%. Even in the scenario with the most drastic measures, the emissions in 2020 will be about 43% above the 1990 level, according to the present report. A stabilization of the global emissions at the 1990 level will require strong measures beyond those assumed in the model calculations, or a considerable breakthrough in energy technology. 17 refs., 5 figs., 21 tabs.

  1. Crude oil &apos;&apos;Windfall Profit&apos;&apos; Tax Act of 1980

    Energy Technology Data Exchange (ETDEWEB)

    Logan, J.S.

    1980-01-01

    Administrative problems and compliance planning opportunities are the focus of this overview of the windfall profit tax on crude oil, which is actually an excise tax of a portion of domestic crude oil revenues that is tied to the removal of existing price controls on domestic crude oil. The retroactive effective date of the statute meant that the Internal Revenue Service had to draft and issue interim rules in haste, and now has to mesh the interim and final regulations with the petroleum industry&apos;s regular business practices. Producers, purchasers, and other who are affected by the tax should be alert to potential problems as well as planning opportunities that may develop during this process. The author provides a roadmap through the existing interim regulations to help interpret new changes. 204 references.

  2. Results of the Danish &apos;&apos;high efficiency motors campaign&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Malmose, K.

    2000-07-01

    In Denmark energy consultancy (demand side management activities (DSM)) took its first steps in the middle of the 80&apos;ies. The energy consultancy was built up around the Danish electric utilities on which the Danish government imposed the implementation of energy savings for funds collected through the electricity bill (approx. 0.0006 DKK/kWh corresponding to approx. 0.001 ECU). The electric utilities trained energy consultants who specialised in visiting industrial enterprises and counselling on energy consumption, primarily focusing on auxiliary systems like lighting, compressed air, ventilation and heating. Within these areas large savings could be obtained because each company was focusing on the actual production but also because the cost of energy was a fraction of the total costs. (orig.)

  3. Fatores de risco cardiovascular em alcoolistas em tratamento

    Directory of Open Access Journals (Sweden)

    Mayla Cardoso Fernandes Toffolo

    2013-06-01

    Full Text Available OBJETIVO: Avaliar a presença de fatores de risco cardiovascular, com ênfase na hipertensão e na adiposidade corporal, em alcoolistas abstinentes ou não abstinentes em tratamento. MÉTODO: Trata-se de um estudo transversal com 65 pacientes alcoolistas em tratamento no CAP-Sad. O grau de dependência do álcool foi avaliado pelo SADD (Short Alcohol Dependence Data e o uso de outras drogas, pelo ASSIST (Alcohol Smoking and Substance Involvement Screening Test. Foram avaliados o perfil bioquímico e o antropométrico dos usuários. RESULTADOS: Participaram do estudo 42 homens e 23 mulheres. A maioria dos participantes (67,74% apresentou dependência alcoólica grave, com uso de álcool associado principalmente a cigarro (66,15%. A média da circunferência da cintura (CC foi significativamente maior entre os abstinentes, em comparação aos não abstinentes (AB: 88,15 ± 15,95 x NA: 81,04 ± 9,86; p = 0,03. Pacientes abstinentes há mais tempo tiveram maior sobrepeso/obesidade e adiposidade abdominal (CC do que os não abstinentes e abstinentes recentes, com razão de chances de 5,25. Os abstinentes apresentaram razão de chances de 3,38 para %GC acima da média, independente do tempo de abstinência. CONCLUSÃO: Pacientes alcoolistas abstinentes apresentam mais sobrepeso/ obesidade, adiposidade corporal (%GC e abdominal (CC do que os não abstinentes. É importante o acompanhamento multiprofissional no tratamento de alcoolistas com abordagem para fatores de risco cardiovasculares, principalmente evitando o ganho de peso.

  4. The &apos;&apos;phase velocity&apos;&apos; of nonlinear plasma waves in the laser beat-wave accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Spence, W.L.

    1985-04-01

    A calculational scheme for beat-wave accelerators is introduced that includes all orders in velocity and in plasma density, and additionally accounts for the influence of plasma nonlinearities on the wave&apos;s phase velocity. The main assumption is that the laser frequencies are very large compared to the plasma frequency - under which it is possible to sum up all orders of forward Raman scattering. It is found that the nonlinear plasma wave does not have simply a single phase velocity, but that the beat-wave which drives it is usefully described by a non-local &apos;&apos;effective phase velocity&apos;&apos; function. A time-space domain approach is followed. (LEW)

  5. Gravity&apos;s rainbow

    Energy Technology Data Exchange (ETDEWEB)

    Magueijo, Joao [Theoretical Physics, Blackett Laboratory, Imperial College, Prince Consort Road, London SW7 2BZ (United Kingdom); Smolin, Lee [Perimeter Institute for Theoretical Physics, Waterloo, N2J 2W9 (Canada)

    2004-04-07

    Nonlinear special relativity (or doubly special relativity) is a simple framework for encoding properties of flat quantum spacetime. In this paper, we show how this formalism may be generalized to incorporate curvature (leading to what might be called &apos;doubly general relativity&apos;). We first propose a dual to nonlinear realization of relativity in momentum space, and show that for such a dual the spacetime invariant is an energy-dependent metric. This leads to an energy-dependent connection and curvature, and a simple modification to Einstein&apos;s equations. We then examine solutions to these equations. We find the counterpart to the cosmological metric, and show how cosmologies based upon our theory of gravity may solve the &apos;horizon problem&apos;. We discuss the Schwarzschild solution, examining the conditions for which the horizon is energy dependent. Finally, we find the weak field limit.

  6. EUGRIS: &apos;&apos;European Substainable Land and Groundwater Management Information System&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Frauenstein, J. [Federal Environmental Agency (UBA), Berlin (Germany)

    2003-07-01

    The presentation outlines and Accompanying Measure with the FP 5 to develop an web based EUropean Sustainable Land and GRoundwater Management Information System information system (EUGRIS). The management of contaminated land and groundwater requires an interdisciplinary approach and a considerable amount of supporting technical information and knowledge. EUGRIS will provide a generally available comprehensive and overarching information and innovation resource, to support both research and practical contaminated land and groundwater management. EUGRI is a gateway to provide a &apos;one stop shop&apos; for information provided by research projects, legislation, standards, best practice and other technical guidance and policy/regulatory publications from the EC, participating Member and Accession States and from various international networks dealing with groundwater and land management issues. Different types of user can access information through different windows according to their needs. EUGRIS will provide its visitors with summary information (digests) and links to sources of more detailed and/or original information in a scaleable holistic and contexturally meaningful way. EUGRIS is being built in three stages: the design of the information system, the development of its software implementation, and the population of the system with information. The presentation is focussed on the concept of the development of the information system with the individual work packages. In the second part of the lecture in particular the work procedures are presented for the content wise replenishment by EUGRIS. The data collation for the proven pilot countries and the production of a European research data base, which opens contents and results of European-wide locked and current projects, form the emphasis thereby. (orig.)

  7. HIPERSENSIBILIDADE DENTINÁRIA: DIAGNÓSTICO E TRATAMENTO

    Directory of Open Access Journals (Sweden)

    VALE Ilan Sampaio do

    1997-01-01

    Full Text Available A hipersensibilidade é a sensibilidade exagerada da dentina quando exposta ao meio bucal, que se torna permeável à ação de estímulos agressivos. O diagnóstico é feito através da anamnese e da inspeção clínica minuciosa. O tratamento pode ser feito pelo profissional ou pelo próprio paciente sob orientação, dependendo do caso. Ela ocorre comumente no final da terceira década, sendo ligeiramente mais freqüente nas mulheres do que nos homens.

  8. Mastigação unilateral : uma modalidade de tratamento

    OpenAIRE

    Valmir Raimundo da Silveira

    2001-01-01

    Resumo: As desordens têmporomandibulares ou alterações funcionais do sistema estomatognático, atingem grande parte da população adulta. Sua etiologia é considerada multifatorial por envolver fatores locais, sistêmicos e psicogênicos. O presente estudo teve por objetivo, detectar a influência da mastigação unilateral sobre a oclusão, alguns musculos envolvidos na mastigação e sobre a articulação têmporomandibular. Foi utilizada uma modalidade de tratamento, fundamentada nas "Leis de cresciment...

  9. Efeitos da acupuntura no tratamento da ansiedade: revisao integrativa

    OpenAIRE

    Sueli Leiko Takamatsu Goyatá; Carolina Costa Valcanti Avelino; Sérgio Valverde Marques dos Santos; Deusdete Inácio de Souza Junior; Maria Dorise Simão Lopes Gurgel; Fábio de Souza Terra

    2016-01-01

    RESUMO Objetivo: avaliar as evidências científicas disponíveis na literatura sobre os efeitos da acupuntura no tratamento da ansiedade e a qualidade desses estudos. Método: revisão integrativa, realizada nas bases/bancos de dados CINAHL, LILACS, PUBMEDPICO, SciELO, The Cochrane Library, no período entre 2001 a 2014. Os descritores anxiety, acupuncture therapy, acupuncture e anxiety disorders foram combinados entre si para garantir a ampla busca de estudos primários. Resultados: dos 514 art...

  10. Tratamento das cefaléias Treatment of headaches

    Directory of Open Access Journals (Sweden)

    José Luiz Dias Gherpelli

    2002-08-01

    Full Text Available Objetivo: realizar revisão bibliográfica sobre o tema tratamento da cefaléia na infância e adolescência. Fontes dos dados: revisão bibliográfica através do banco de dados Medline, utilizando os termos: cefaléia, enxaqueca ou migrânea, infância ou adolescência e tratamento, no período de 1966 a 2001, excluindo artigos de revisão e registros de casos. Foram selecionados artigos científicos que relataram estudos sobre a eficácia da terapêutica farmacológica e não farmacológica no tratamento das cefaléias primárias. Síntese dos dados: foram encontrados 104 artigos científicos, sendo selecionados aqueles que relataram estudos do tipo caso-controle, ou droga versus placebo, cegos ou abertos, e que estudassem crianças ou adolescentes. Conclusões: é digna de nota a pobreza de estudos controlados sobre o tema na faixa etária pediátrica, apesar da importância que as cefaléias primárias apresentam na prática clínica. Apenas algumas drogas foram estudadas de forma cientificamente adequada e, mesmo assim, o número de estudos é pequeno. Tanto o tratamento da crise álgica aguda quanto a profilaxia da cefaléia foram abordados.Objective: to perform a bibliographic review about headache treatment in childhood and adolescence. Sources: articles were searched through Medline database using the terms: migraine, or headache, childhood, or adolescence, and treatment, during the period between 1966 and 2001. Review articles and case reports were excluded. Only articles dealing with pharmacological, and non-pharmacological treatment of primary headaches were selected. Summary of the findings: a total of 104 articles were found; only those reporting results of the case-control studies, or drug vs. placebo, either blind, or open, and that included children, or adolescents were selected. Conclusions: only a few controlled studies about the headache treatment were found in the pediatric age group, although primary headaches are

  11. Biological effect and tumor risk of diagnostic x-rays. The &apos;&apos;war of the theories&apos;&apos;; Biologische Wirkung und Tumorrisiko diagnostischer Roentgenstrahlen. Der &apos;&apos;Krieg der Modelle&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Selzer, E.; Hebar, A. [Medizinische Universitaet Wien, Abteilung fuer Strahlenbiologie, Klinik fuer Strahlentherapie, Wien (Austria)

    2012-10-15

    Since the introduction of ionizing radiation as a treatment and diagnostic tool in humans, scientists have been trying to estimate its side effects and potential health risks. There is now ample evidence for the principal existence of a direct relationship between higher doses and the risks of side effects. Most of the uncertainties lie in the field of low-dose effects especially with respect to the risk of cancer induction. Low-dose effects are usually of relevance in diagnostic medicine while high-dose radiation effects are typically observed after radiotherapeutic treatment for cancer or after nuclear accidents. The current state of the &apos;&apos;war of theories&apos;&apos; may be summarized as follows: one group of scientists and health regulatory officials favors the hypothesis that there is no threshold dose, i.e. the linear-no-threshold hypothesis (LNT) of radiation which can be regarded as safe. On the contrary, the critics of this hypothesis suggest that the risks of doses below 50 mSv are not measurable or even of clinical relevance and are not adequately described by a linear dose-response relationship. The aim of this article is to summarize the major unresolved issues in this field. Arguments are presented why the validity of the LNT model in the low-dose range should be regarded as at least inconsistent and is thus questionable. (orig.) [German] Seit der Einfuehrung ionisierender Strahlen als ein Mittel zur Behandlung und Diagnose beim Menschen haben Wissenschaftler versucht, ihre Nebenwirkungen und potenziellen Risiken fuer die Gesundheit einzuschaetzen. Es gibt nun ausreichende Evidenz fuer das grundsaetzliche Vorliegen einer direkten Beziehung zwischen hoeheren Dosen und Nebenwirkungsrisiken. Die meisten Unsicherheiten liegen auf dem Gebiet der Niedrigdosisforschung v. a. im Hinblick auf das Risiko der Induktion von Krebs. Niedrigdosiseffekte sind ueblicherweise von Bedeutung in der diagnostischen Medizin, waehrend Hochdosisbestrahlungseffekte

  12. EAWAG Forum Chriesbach - A &apos;sustainable&apos; new building; EAWAG Forum Chriesbach - Ein &apos;nachhaltiger Neubau&apos; / A &apos;sustainable&apos; new building

    Energy Technology Data Exchange (ETDEWEB)

    Bundi, U. [EAWAG, Duebendorf (Switzerland); Gantenbein, K. [Hochparterre, Zuerich (Switzerland); Preisig, H. [Prof. Hansruedi Preisig, Zuerich (Switzerland); Kasser, U. [Ueli Kasser, Zuerich (Switzerland)

    2006-07-01

    This monograph describes the &apos;Forum Chriesbach&apos; - a new building for Swiss Federal Institute of Aquatic Science and Technology EAWAG in Duebendorf, Switzerland. The history behind the project and its sustainable concept are discussed. Basic Ideas and an analogy to a typical Swiss farmhouse of earlier centuries are examined. The teamwork that was needed for the building&apos;s realisation is also noted. Architectural topics and the treatment of the building as a total system are discussed. Further topics include water, sanitary installations, material ecology and grey energy. Further, the monograph deals with the realisation of the building, presents key figures and energy balances and comments on the planning and building processes involved.

  13. Documentation to the workshop &apos;Cluster in the environmental protection economy&apos;; Dokumentation zum Workshop &apos;&apos;Cluster in der Umweltschutzwirtschaft&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-12-11

    Within the workshop &apos;Cluster in the environmental protection economy&apos; at the Umweltbundesamt (Dessau-Rosslau, Federal Republic of Germany) at 27th November, 2008, the following lectures were held: (a) Which contribution can cluster and cluster politics contribute to the promotion of the environmental protection economy? (Harald Legler); (b) Cluster in the environmental protection economy: Targets and expectations (Dieter Rehfeld); (c) Demands at the management of clusters (Karin Hoerhan); (d) Demands at the cluster politics in the environmental protection economy (Bernhard Hausberg); (e) Photovoltaics in Eastern Germany (Johann Wackenbauer); (f) Automotive industry in Bergisches Land (Thomas Lemken); (g) Competence centre environment Augsburg-Schwaben (Egon Beckord).

  14. Craniotomia descompressiva bifrontal no tratamento do edema cerebral grave

    Directory of Open Access Journals (Sweden)

    Walter C. Pereira

    1977-06-01

    Full Text Available São apresentados os resultados obtidos com craniotomia descompressiva bifrontal ampla em 12 doentes com edema cerebral grave e irreversível com os métodos convencionais de tratamento, provocado em 10 por traumatismo crânio-encefálico. Todos os pacientes apresentavam quadro neurológico muito grave, com sinais de comprometimento do tronco cerebral superior. Angiografia caro-tídea bilateral foi praticada sistematicamente, tanto no pré como no pós-operatório, constituindo-se no fator decisivo para a indicação cirúrgica. Seis (50% dos doentes sobreviveram, apresentando 5 (41,6% recuperação neurológica e psíquica praticamente totais. Levando em conta estes resultados, consideramos esta técnica cirúrgica o melhor recurso de tratamento em tais casos, máxime se indicada precocemente. São necessários, contudo, cuidados pós-operatórios especiais com estes pacientes, que devem, sempre que possível, ser mantidos em unidade de terapia intensiva, em virtude da grande incidência de complicações, mormente respiratórias.

  15. Modelo preditivo ao abandono do tratamento da tuberculose

    Directory of Open Access Journals (Sweden)

    Eveline de Almeida Silva

    Full Text Available Objetivou-se construir um modelo preditivo tomando como variáveis explicativas as características dos indivíduos com tuberculose para definir o tratamento mais adequado. Pesquisa do tipo observacional descritiva, de abordagem quantitativa. A população alvo (n=1925 foi retirada do Sistema de Informação de Agravos de Notificação de João Pessoa- PB, entre 2001 e 2008. No modelo final a razão de chances (OR das variáveis para o risco ao abandono foram: escolaridade em ensino médio (OR=1,56 e em ensino superior (OR=42,99, cor (OR=2,29 e reingresso após abandono (OR=2,71. A tomada de decisão deverá ser direcionada ao modelo de melhor adequação para se identificar os indivíduos passíveis de abandonar o tratamento.

  16. Fadiga em idosos em tratamento quimioterápico

    Directory of Open Access Journals (Sweden)

    Thalyta Cristina Mansano-Schlosser

    2014-07-01

    Full Text Available Pesquisa com delineamento transversal, realizada de agosto a dezembro de 2010, que objetivou identificar a presença e intensidade da fadiga em 140 idosos (média de idade 69,8 anos, 52,1% do sexo feminino com diagnóstico de câncer, em tratamento quimioterápico ambulatorial. Utilizou-se um questionário para caracterização sociodemográfica e clínica e a Escala de Fadiga de Piper-revisada. Identificou-se a presença de fadiga em 60 idosos (42,9% e a causa atribuída foi o câncer (64,1%, a quimioterapia (32,8% e o tratamento (3,1%. Como fator de alívio, os idosos entrevistados relataram "dormir", "rezar" e "morrer", enquanto 45% deles disseram "não ter o que fazer", pois a fadiga não poderia ser aliviada. Espera-se que este estudo alerte os profissionais de enfermagem para a relevância da fadiga e os estimule a identificar e realizar intervenções de enfermagem que visem o adequado manejo desse sintoma no paciente idoso oncológico.

  17. Tratamento do transtorno esquizoafetivo Treatment of the schizoaffective disorder

    Directory of Open Access Journals (Sweden)

    Lucas de Castro Quarantini

    2005-01-01

    Full Text Available O tratamento farmacológico do transtorno esquizoafetivo (TE é usualmente realizado com antipsicóticos, estabilizadores do humor e antidepressivos. Verifica-se a falta de estudos epecificamente desenhados para avaliar a resposta de pacientes esquizoafetivos à medicação. Portanto, as informações sobre o tratamento de pacientes com TE são derivadas de bancos de dados de paciente com esquizofrenia e transtornos bipolares. Dados de pesquisa apóiam a idéia de um continuum entre os transtornos bipolares e a esquizofrenia. As duas condições podem ser tratadas com antipsicóticos, o que pode refletir uma base fisiopatológica comum para ambas.The pharmacological treatment of schizoaffective disorders (SD is usually carried out with antipsychotics, mood stabilizers and antidepressants. There is a lack of clinical trials specifically designed to assess the clinical response of schizoaffective patients to medication. Therefore, data on the treatment of patients with SD is largely derived from datasets of patients with schizophrenia and bipolar disorders. Research data support the idea of a continuum between bipolar and schizophrenic disorders. Both disorders can be treated with antipsychotics and this may reflect a common pathophysiological diathesis.

  18. Estimation of doses to patients from &apos;'complex'&apos; conventional X-ray examinations

    Energy Technology Data Exchange (ETDEWEB)

    Calzado, A.; Vano, E.; Moran, P.; Ruiz, S.; Gonzalez, L. (Universidad Complutense de Madrid (Spain). Catedra de Fisica Medica); Castellote, C. (Hospital Militar Central ' ' Gomez Ulla' ' , Madrid (Spain). Dept. de Radiologia)

    1991-06-01

    A numerical method has been developed to estimate organ doses and effective dose-equivalent for patients undergoing three &apos;complex&apos; examinations (barium meal, barium enema and intravenous urography). The separation of radiological procedures into a set of standard numerical views is based on the use of Monte Carlo conversion factors and measurements within a Remab phantom. Radiation doses measured in a phantom for such examinations were compared with predictions of the &apos;'numerical'&apos; method. Dosimetric measurements with thermoluminescent dosemeters attached to the patient&apos;s skin along with measurements of the dose-area product during the examination have enabled the derivation of organ doses and to estimate effective dose-equivalent. Mean frequency weighted values of dose-area product, energy imparted to the patient, doses to a set of organs and effective dose-equivalent in the area of Madrid are reported. Comparisons of results with those from similar surveys in other countries were made. (author).

  19. Aukso ir sidabro dangų, užteptų ant vario padėklų, elastingumo modulio, nanokiečio ir liekamųjų įtempių nustatymas

    Directory of Open Access Journals (Sweden)

    Harri LILLE

    2012-03-01

    Full Text Available Šiame darbe tiriamos užteptos aukso dangos dažniausiai naudojamos remontuojant generatorių komutatorius ir slankiuosius kontaktus, daugiausia pagamintus iš vario. Atsižvelgiant į kainą, elektronikos komponentuose auksas kartais pakeičiamas sidabru. Nikeliu sukietintos aukso ir sidabro dangos buvo gaunamos ant plonasienio varinio žiedo padėklo užtepant komercinį SIFCO Dalic tirpalą –  kietą aukso lydinį (kodas SPS 5370, ir labai kieto sidabro lydinį (kodas SPS 3080. Elastingumo modulio ir nanokiečio vertės buvo nustatytos naudojant nanoindentorių „MTS Nano Indenter XR®“ ir mikrokiečio bandiklį. Liekamieji įtempiai dangose buvo apskaičiuojami iš padėklų tempimo įtempių kreivių pokyčių. Buvo pastebėtas tiesiškai trupmeninis liekamųjų įtempių mažėjimas. Liekamieji įtempiai aukso ir sidabro dangose ypač mažėja pirmosiomis savaitėmis. Lygtys, aproksimuojančios liekamųjų įtempių pokyčius, leidžia numatyti dangų liekamųjų įtempių pabaigą eksploatavimo periodu. Dangų paviršių morfologija ir mikrostruktūra buvo tiriama rastriniu mikroskopu.DOI: http://dx.doi.org/10.5755/j01.ms.18.1.1341

  20. Tratamento adjuvante nos GISTs Adjuvant treatment in GISTs

    Directory of Open Access Journals (Sweden)

    Laercio Gomes Lourenço

    2011-09-01

    Full Text Available INTRODUÇÃO: O tumor estromal gastrointestinal (GIST é o sarcoma mais comum do aparelho digestivo. Essa neoplasia ocorre devido à mutação do gene KIT com consequente ativação constitutiva da proteína KIT. O tratamento primário é cirúrgico e consiste na sua ressecção completa. Entretanto, alguns grupos de pacientes apresentam risco elevado de recorrência mesmo após operação com ressecção completa (R0, indicando diferenças no comportamento biológico. Estudos clínicos comprovaram a atividade clínica do mesilato de imatinibe, fazendo dele a primeira linha de tratamento padrão nos GISTs metastáticos ou irressecáveis, mudando muito o desfecho clínico dessa doença em relação aos benefícios anteriormente obtidos com a quimioterapia antineoplásica. MÉTODO: Foi realizada revisão da literatura com consulta nos periódicos das bases Medline/Pubmed, Scielo e Lilacs cruzando os descritores: tumor estromal gastrointestinal, Gist, tratamento, adjuvância. Além desta revisão foi adicionada a experiência pessoal dos autores. CONCLUSÃO: Melhor refinamento dos critérios de prognóstico tem permitido selecionar de forma mais adequada pacientes para o tratamento adjuvante com imatinibe. Os resultados de maior evidência até o momento respaldam o tratamento adjuvante por um ano, o que produz benefício significativo na sobrevida livre de recidiva, mas não na sobrevida global desses pacientes.INTRODUCTION: Gastrointestinal stromal tumor (GIST is the most common sarcoma of the digestive tract. This cancer occurs due to mutation of the KIT gene resulting in constitutive activation of KIT protein. The primary treatment is surgical and consists of complete resection. However, some groups of patients at high risk of recurrence even after surgery with complete resection (R0, indicate differences in biological behavior. Clinical studies have demonstrated the clinical activity of imatinib mesylate, making it the standard first

  1. Efetividade do tratamento da tuberculose Effectiveness of tuberculosis treatment

    Directory of Open Access Journals (Sweden)

    Letícia Nazareth Fernandes da Paz

    2012-08-01

    Full Text Available OBJETIVO: Analisar as estratégias que influenciam a efetividade do tratamento da tuberculose em Unidades Básicas de Saúde (UBS. MÉTODOS: Levantamento epidemiológico, descritivo, retrospectivo, envolvendo os prontuários médicos de 588 pacientes com tuberculose cadastrados no programa de controle da tuberculose, entre janeiro de 2004 e dezembro de 2008, em duas UBS - Centro de Saúde Escola do Marco (CSEM e UBS da Pedreira (UBSP - localizadas na cidade de Belém (PA. Os critérios de exclusão foram ter idade 59 anos e ter alta por transferência ou mudança de diagnóstico. Os dados coletados foram idade, sexo, tipo de tratamento (autoadministrado ou supervisionado, coinfecção por HIV e desfecho do tratamento. Os profissionais de saúde envolvidos no programa da tuberculose das duas UBS foram entrevistados quanto às estratégias utilizadas no controle da doença e à rotina de atendimento. RESULTADOS: Não houve diferenças significativas quanto a idade, sexo e coinfecção com HIV nas duas UBS. A utilização de tratamento supervisionado foi significativamente maior no CSEM que na UBSP, assim como a taxa de cura, enquanto a taxa de abandono foi maior na UBSP que no CSEM. CONCLUSÕES: Para pacientes cadastrados em programas de controle da tuberculose em UBS no Brasil, o tratamento supervisionado provavelmente é uma estratégia de extrema importância para se alcançar uma menor taxa de abandono.OBJECTIVE: To analyze the treatment strategies that influence the effectiveness of tuberculosis treatment at primary care clinics (PCCs in Brazil. METHODS: This was a descriptive, retrospective epidemiological survey based on the medical records of 588 tuberculosis patients enrolled in the tuberculosis control programs at two PCCs located in the city of Belém, Brazil: Centro de Saúde Escola do Marco (CSEM and Unidade Básica de Saúde da Pedreira (UBSP. The survey was limited to patients enrolled between January of 2004 and December of 2008

  2. &apos;Catapult&apos; offshore renewables into commercial use

    Energy Technology Data Exchange (ETDEWEB)

    Block, Elizabeth

    2012-07-01

    In February, the Technology Strategy Board, the UK&apos;s government innovation agency, appointed a consortium to set up the Offshore Renewable Energy Catapult centre, with Sterling Pounds 50 million to be spent over five years. (orig.)

  3. Container design testing for the final repository Konrad - experiences with respect to so called &apos;'old'&apos; containers; Bauartpruefungen an Behaeltern fuer das Endlager KONRAD. Erfahrungen bezueglich sog. &apos;'Alt'&apos;-Behaelter

    Energy Technology Data Exchange (ETDEWEB)

    Noack, Volker; Voelzke, Holger; Nieslony, Gregor; Kovacs, Oliver; Hagenow, Peter [BAM Bundesanstalt fuer Materialforschung und -pruefung (Germany)

    2009-07-01

    The Konrad ore mine is a final repository for low- and intermediate-level radioactive waste in Germany. The demand for final storage suitable containers is increasing. The authors describe tests of so called &apos;'old'&apos; containers for qualification with respect to the appropriateness for final disposal. BAM (Bundesanstalt fuer Materialpruefung) has test facilities for drop tests and fire tests. The testing requirements for all available container types are discussed, including the boundary conditions with respect to the supposed waste properties, conditioning and loading. The project of container design testing is aimed to the possibility of a continuous recording of a large amount of waste packages for the final repository Konrad that allows a short-term backtracking of the relevant data for quality assurance.

  4. Characterisation of epeiric &apos;'layer-cake'&apos; carbonate reservoirs: Upper Muschelkalk (Middle Triassic), the Netherlands

    Energy Technology Data Exchange (ETDEWEB)

    Borkhataria, R.; Aigner, T.; Poeppelreiter, M.C.; Pipping, J.C.P. [Shell International Exploration and Production Inc., Houston, TX (United States)

    2005-04-01

    Upper Muschelkalk (Middle Triassic) carbonates produce natural gas at Coevorden field in the NE Netherlands. This is currently the only field that produces gas from this succession although several other prospects have been identified nearby. In order to help develop these hydrocarbons, this study proposes a facies and reservoir model of the Upper Muschelkalk in the NE Netherlands together with a regional framework intended to assist in further evaluation. Distribution of facies and reservoir properties of the Upper Muschelkalk carbonates in the NE Netherlands indicate deposition on a storm-dominated epeiric ramp with a very low gradient. The predominantly muddy and marly lithofacies types in proximal and distal parts of the ramp gradually interfinger with a shoreline-detached &apos;'shoal'&apos;-like ooidal grainstone complex. The best reservoir quality (permeability up to 60 mD) is recognised within dolomitised peloid ooid grainstones. These are interpreted as high-energy backshoal deposits. Reservoir quality decreases in the limestone-dominated &apos;'shoal'&apos; facies and the muddier foreshoal facies. A four-fold hierarchy of depositional cycles describes the systematic and thus predictable vertical variation in reservoir quality (permeability) and quantity (net-to-gross). High-resolution correlation suggests that medium-scale cycles (5 to 15 metres thick) can be traced for hundreds of kilometres. Small-scale cycles (1 to 3 metres thick) are persistent for several tens of kilometres and have sheet-like geometries. Individual reservoir units (several decimetres thick) appear to be laterally continuous over a maximum of a few kilometres although internal flow barriers might be expected. Mapping of Upper Muschelkalk thickness and facies has clearly defined backshoal, &apos;'shoal'&apos; and foreshoal facies belts with distinctly different reservoir characteristics. Typically, reservoir quality and quantity decrease with increasing

  5. Swiss &apos;Electricity&apos; Research Programme 2004-2007; Konzept des Forschungsprogramms &apos;Elektrizitaet&apos; 2004 - 2007

    Energy Technology Data Exchange (ETDEWEB)

    Brueniger, R.

    2004-07-01

    This report issued by the Swiss Federal Office of Energy (SFOE) provides details on Swiss research in the electricity area that is foreseen for the period 2004-2007. The report discusses the current state of electricity research and the strategic goals for the period and presents the organisations involved and their previous work. The general main areas of interest addressed by the programme are noted, such as the storage and transport of electricity as well as its use in communication technologies, motors, domestic appliances and industrial applications. Figures are presented on the programme&apos;s finances and the concept of &apos;trend-watching&apos; groups is briefly addressed.

  6. What does &apos;'Platinum'&apos; mean? Reflections on the development of sustainability assessment methods; Was bedeutet &apos;'Platin'&apos;? - Zur Entwicklung von Nachhaltigkeitsbewertungsverfahren

    Energy Technology Data Exchange (ETDEWEB)

    Gertis, Karl [Lehrstuhl fuer Bauphysik, Universitaet Stuttgart (Germany); Hauser, Gerd [echnischen Universitaet Muenchen (Germany); Sedlbauer, Klaus [Universitaet Stuttgart (DE). Fraunhofer-Institut fuer Bauphysik (IBP); Sobek, Werner [Universitaet Stuttgart (DE). Institut fuer Leichtbau Entwerfen und Konstruieren (ILEK)

    2008-08-15

    The current political discussion on climate change is heavily biased towards CO{sub 2} balance, energy consumption and energy costs associated with rising energy prices. The good news is that the German Government covers sustainability in the construction sector, including - and indeed going far beyond - energy conservation. To this end the German Sustainable Building Council (DGNB) was formed in 2007, although it is worth noting that Great Britain introduced a relatively advanced sustainability assessment method referred to as BREEAM as early as 1990, an enhanced version of which was released in the USA in 1995 under the name of LEED. This article tries to show &apos;'rootstocks'&apos; for the sustainability assessment, to set up a classification system for criteria, and to derive consequences. (Abstract Copyright [2008], Wiley Periodicals, Inc.) [German] In der derzeitigen politischen Diskussion ueber die Klimaveraenderung wird der CO{sub 2}-Bilanz und dem Energieverbrauch bzw. den mit steigenden Energiepreisen verbundenen Energiekosten eine fast ueberlastige Bedeutung beigemessen. Umso erfreulicher ist es, dass sich die Bundesregierung mit einem Leitfaden auch der Nachhaltigkeit des Bauens annimmt, welche die Energieeinsparung einschliesst, aber weit ueber diese hinausgeht, und dass sich hierzu im Jahre 2007 - wenn auch im internationalen Vergleich spaet - die Deutsche Gesellschaft fuer nachhaltiges Bauen (DGNB) gebildet hat; verspaetet deshalb, weil in Grossbritannien mit BREEAM bereits 1990 ein relativ ausgereiftes Nachhaltigkeitsbewertungsverfahren bekannt geworden war, auf das in den USA mit LEED 1995 aufgebaut wurde. Die vorliegende Arbeit versucht, &apos;'Grundstoecke'&apos; fuer die Nachhaltigkeitsbeurteilung aufzuzeigen, ein Kriterien-Ordnungssystem aufzubauen und daraus einige Konsequenzen abzuleiten. (Abstract Copyright [2008], Wiley Periodicals, Inc.)

  7. A &apos;missing&apos; family of classical orthogonal polynomials

    Energy Technology Data Exchange (ETDEWEB)

    Vinet, Luc [Centre de Recherches Mathematiques, Universite de Montreal, PO Box 6128, Centre-ville Station, Montreal, Quebec, H3C 3J7 (Canada); Zhedanov, Alexei, E-mail: zhedanov@fti.dn.ua [Donetsk Institute for Physics and Technology, Donetsk 83114 (Ukraine)

    2011-02-25

    We study a family of &apos;classical&apos; orthogonal polynomials which satisfy (apart from a three-term recurrence relation) an eigenvalue problem with a differential operator of Dunkl type. These polynomials can be obtained from the little q-Jacobi polynomials in the limit q = -1. We also show that these polynomials provide a nontrivial realization of the Askey-Wilson algebra for q = -1.

  8. The &apos;Instrumental&apos; Reality of Phlogiston

    OpenAIRE

    Mi Gyung Kim

    2008-01-01

    The stability of phlogiston in eighteenth-century French chemistry depended not on its role as a comprehensive theory, but on its operational (instrumental), theoretical, and philosophical (speculative) identities that were forged in different contexts, yet were interwoven to designate a single substance. It was as &apos;real&apos; as any other chemical substance to the degree that it was obtained through material operations, occupied a place in the theoretical edifice of the affinity table, ...

  9. &apos;&apos;Life-cycle costs&apos;&apos; of industrial electric drives in the process industry - energy consumption and economics of electric drives

    Energy Technology Data Exchange (ETDEWEB)

    Bieniek, K. [BASF AG, Ludwigshafen (Germany)

    2000-07-01

    For electric motors in the process industry, the purchase price is only a small fraction of the overall &apos;&apos;life-cycle costs&apos;&apos;. The most important criteria are reliability, noise and efficiency. The engineering expense for assessing energy consumption must be kept in accordance to the saving potential. In the German chemical industry, reliability has attained an encouragingly high level thanks to applying the &apos;&apos;VIK recommendations&apos;&apos;. Standardised sizes (&apos;&apos;European standard motor&apos;&apos;) guarantee the interchangeability. That gives also a good basis for introducing improved motors, e.g. with less noise or with better efficiency. Today&apos;s market offers already a high level of efficiencies: Improvements will justify only small price increases. Despite their large number, small motors of less than 1 kW consume only a small percentage of the total electricity demand in a plant, and for large motors (above 100 kW) energy losses are already evaluated in detail. For the &apos;&apos;standard motors&apos;&apos; approximately between 1 and 100 kW, a standardised classification and labelling of the motor efficiencies will be a useful tool for selecting the optimal motors for their applications. To ensure interchangeability, the motor sizes and installation dimensions must remain unchanged. (orig.)

  10. Folate targeted polymeric &apos;green&apos; nanotherapy for cancer

    Energy Technology Data Exchange (ETDEWEB)

    Narayanan, Sreeja; Binulal, N S; Mony, Ullas; Manzoor, Koyakutty; Nair, Shantikumar; Menon, Deepthy, E-mail: deepthymenon@aims.amrita.edu [Amrita Center for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi-682 041, Kerala (India)

    2010-07-16

    The concept of &apos;green&apos; chemotherapy by employing targeted nanoparticle mediated delivery to enhance the efficacy of phytomedicines is reported. Poly (lactide-co-glycolide) (PLGA) nanoparticles encapsulating a well known nutraceutical namely, grape seed extract (GSE)-&apos;NanoGSE&apos;-was prepared by a nanoprecipitation technique. The drug-loaded nanoparticles of size {approx} 100 nm exhibited high colloidal stability at physiological pH. Molecular receptor targeting of this nanophytomedicine against folate receptor over-expressing cancers was demonstrated in vitro by conjugation with a potential cancer targeting ligand, folic acid (FA). Fluorescence microscopy and flow cytometry data showed highly specific cellular uptake of FA conjugated NanoGSE on folate receptor positive cancer cells. Studies were also conducted to investigate the efficiency of targeted (FA conjugated) versus non-targeted (non-FA conjugated) nanoformulations in causing cancer cell death. The IC{sub 50} values were lowered by a factor of {approx} 3 for FA-NanoGSE compared to the free drug, indicating substantially enhanced bioavailability to the tumor cells, sparing the normal ones. Receptor targeting of FA-NanoGSE resulted in a significant increase in apoptotic index, which was also quantified by flow cytometry and fluorescence microscopy. This in vitro study provides a basis for the use of nanoparticle mediated delivery of anticancer nutraceuticals to enhance bioavailability and effectively target cancer by a &apos;green&apos; approach.

  11. ApoE4 induces synaptic and ERG impairments in the retina of young targeted replacement apoE4 mice.

    Directory of Open Access Journals (Sweden)

    Ran Antes

    Full Text Available The vertebrate retina, which is part of the central nervous system, is a window into the brain. The present study investigated the extent to which the retina can be used as a model for studying the pathological effects of apolipoprotein E4 (apoE4, the most prevalent genetic risk factor for Alzheimer's disease (AD. Immunohistochemical studies of retinas from young (4 months old apoE4-targeted replacement mice and from corresponding mice which express the AD benign apoE3 allele, revealed that the density of the perikarya of the different classes of retinal neurons was not affected by apoE4. In contrast, the synaptic density of the retinal synaptic layers, which was assessed immunohistochemically and by immunoblot experiments, was significantly lower in the apoE4 than in the apoE3 mice. This was associated with reduced levels of the presynaptic vesicular glutamatergic transporter, VGluT1, but not of either the GABAergic vesicular transporter, VGaT, or the cholinergic vesicular transporter, VAChT, suggesting that the glutamatergic nerve terminals are preferentially affected by apoE4. In contrast, the post synaptic scaffold proteins PSD-95 and Gephyrin, which reside in excitatory and inhibitory synapses, respectively, were both elevated, and their ratio was not affected by apoE4. Electroretinogram (ERG recordings revealed significant attenuation of mixed rod-cone responses in dark-adapted eyes of apoE4 mice. These findings suggest that the reduced ERG response in the apoE4 mice may be related to the observed decrease in the retinal nerve terminals and that the retina could be used as a novel model for non-invasive monitoring of the effects of apoE4 on the CNS.

  12. Postprandial apoE isoform and conformational changes associated with VLDL lipolysis products modulate monocyte inflammation.

    Directory of Open Access Journals (Sweden)

    Laura J den Hartigh

    Full Text Available Postprandial hyperlipemia, characterized by increased circulating very low-density lipoproteins (VLDL and circulating lipopolysaccharide (LPS, has been proposed as a mechanism of vascular injury. Our goal was to examine the interactions between postprandial lipoproteins, LPS, and apoE3 and apoE4 on monocyte activation.We showed that apoE3 complexed to phospholipid vesicles attenuates LPS-induced THP-1 monocyte cytokine expression, while apoE4 increases expression. ELISA revealed that apoE3 binds to LPS with higher affinity than apoE4. Electron paramagnetic resonance (EPR spectroscopy of site-directed spin labels placed on specific amino acids of apoE3 showed that LPS interferes with conformational changes normally associated with lipid binding. Specifically, compared to apoE4, apoE bearing the E3-like R112→Ser mutation displays increased self association when exposed to LPS, consistent with a stronger apoE3-LPS interaction. Additionally, lipolysis of fasting VLDL from normal human donors attenuated LPS-induced TNFα secretion from monocytes to a greater extent than postprandial VLDL, an effect partially reversed by blocking apoE. This effect was reproduced using fasting VLDL lipolysis products from e3/e3 donors, but not from e4/e4 subjects, suggesting that apoE3 on fasting VLDL prevents LPS-induced inflammation more readily than apoE4.Postprandial apoE isoform and conformational changes associated with VLDL dramatically modulate vascular inflammation.

  13. Neutrino--gaseous &apos;'pancakes'&apos; in cosmology, and the missing-mass problem

    Energy Technology Data Exchange (ETDEWEB)

    Doroshkevich, A.G.

    1983-07-01

    If allowance is made for the random thermal velocities of the massive neutrinos, the density of the gaseous (baryon) component will dominate the neutrino density in the central part of a primordial &apos;'pancake'&apos; (rho/sub b/>rho/sub ..nu../), even though on the average rho-bar/sub b/<

  14. Computerized axial tomography of the chest for visualization of &apos;'absent'&apos; pulmonary arteries

    Energy Technology Data Exchange (ETDEWEB)

    Sondheimer, H.M. (Upstate Medical Center, Syracuse, NY); Oliphant, M.; Schneider, B.; Kavey, R.E.W.; Blackman, M.S.; Parker, F.B. Jr.

    1982-05-01

    To expand the search for central pulmonary arteries in six patients with absence of cardiac-pulmonary continuity, computerized axial tomography (CAT) of the chest was performed. The CAT scans were compared with previous arteriograms and pulmonary vein wedge angiograms. Three patients with type IV truncus arteriosus were studied, and none had a central, right or left pulmonary artery on CAT scan. However, two patients with tetralogy of Fallot with pulmonary atresia and a patent ductus arteriosus to the right lung demonstrated the presence of a left pulmonary artery. In addition, one child with truncus arteriosus with &apos;'absent'&apos; left pulmonary artery demonstrated a left pulmonary artery on the CAT scan. The CAT scan may therefore enhance our ability to search for disconnected pulmonary arteries in children with complex cyanotic congenital heart disease.

  15. Equation of &apos;'state'&apos; for thermoremanent magnetization in micron-size powders of copper oxide superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Shaw, G.; Agrawala, G.; Bhagat, S.M. (Dept. of Physics, Center for Superconductivity Research, Univ. of Maryland, College Park, MD (USA))

    1991-04-01

    We have extended previous studies on the time and temperature dependence of M{sub ZFC}, M{sub FC} and M{sub TRM} of Y{sub 1}Ba{sub 2}Cu{sub 3}O{sub 7} powders to encompass a variety of sizes and methods of preparation. The slow long term decays are confirmed over a wider time span. The T dependence of M{sub TRM} is well described by M{sub TRM}proportional to (1-(T/Tc)){sup q} and this &apos;&apos;equation of state&apos;&apos; is rendered plausible on the basis of a model involving thermally assisted escape of individual fluxons. (orig.).

  16. Comment on &apos;Note on Faraday&apos;s law and Maxwell&apos;s equations&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Redzic, Dragan V [Faculty of Physics, University of Belgrade, PO Box 368, 11001 Beograd (Yugoslavia)], E-mail: redzic@ff.bg.ac.yu

    2008-11-15

    We discuss some problematic contentions in a recent note on Faraday&apos;s law (Kholmetskii et al 2008 Eur. J. Phys. 29 N5-10). We also do justice to Hertz, Helmholtz and Maxwell. (letters and comments)

  17. &apos;&apos;{sup local}Renewables model communities network&apos;&apos;. An international initiative by ICLEI

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Emani [ICLEI South Asia Secretariat, Noida (India); Macedo, Laura Valente de [ICLEI Latin America and Caribbean Secretariat, Buenos Aires, DF (Argentina); Staden, Maryke van [ICLEI European Secretariat, Freiburg (Germany)

    2008-07-01

    Local governments (LGs) play a crucial role in implementing local energy policies, ensuring effective regulations, managing assets and providing a wide range of services that impact energy consumption. It is clear that they must also be key players in the transformation to sustainable energy in their communities. The &apos;&apos;{sup local}Renewables Model Communities Network&apos;&apos; (LR), an initiative of ICLEI - Local Governments for Sustainability, to build an international network of communities committed to sustainable energy. The participating cities and towns from developing and developed countries act as role models, and encourage others. LR network communities share information on aspects of sustainable energy, experiences and expertise, from policies to technologies, from stakeholder involvement to implementation processes. LGs around the globe have to become active in the field of sustainable energy. The also require support from various actors, including international cooperation and exchange to support their transition towards sustainable energy solutions. (orig.)

  18. Prospects for neutron star equation of state constraints using &apos;'recycled'&apos; millisecond pulsars

    Energy Technology Data Exchange (ETDEWEB)

    Bogdanov, Slavko [Columbia University, Columbia Astrophysics Laboratory, New York, NY (United States)

    2016-02-15

    &apos;'Recycled'&apos; millisecond pulsars are a variety of rapidly spinning neutron stars that typically show thermal X-ray radiation due to the heated surface of their magnetic polar caps. Detailed numerical modeling of the rotation-induced thermal X-ray pulsations observed from recycled millisecond pulsars, including all relevant relativistic and stellar atmospheric effects, has been identified as a promising approach towards an astrophysical determination of the true neutron star mass-radius relation, and by extension the state of cold matter at densities exceeding those of atomic nuclei. Herein, I review the basic model and methodology commonly used to extract information regarding neutron star structure from the pulsed X-ray radiation observed from millisecond pulsars. I also summarize the results of past X-ray observations of these objects and the prospects for precision neutron star mass-radius measurements with the upcoming Neutron Star Interior Composition Explorer (NICER) X-ray timing mission. (orig.)

  19. Exposição ao vivo no tratamento de agorafobia: relato de caso

    Directory of Open Access Journals (Sweden)

    Gustavo J. Fonseca D'El Rey

    Full Text Available Relato de caso, em que a Exposição ao Vivo foi utilizada no tratamento de paciente com diagnóstico de agorafobia. O tratamento foi realizado em doze sessões, apresentando êxito no uso dessa técnica comportamental.

  20. Quantum dynamics via Planck-scale-stepped action-carrying &apos;Graph Paths&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Chew, Geoffrey F.

    2003-05-05

    A divergence-free, parameter-free, path-based discrete-time quantum dynamics is designed to not only enlarge the achievements of general relativity and the standard particle model, by approximations at spacetime scales far above Planck scale while far below Hubble scale, but to allow tackling of hitherto inaccessible questions. &apos;&apos;Path space&apos;&apos; is larger than and precursor to Hilbert-space basis. The wave-function-propagating paths are action-carrying structured graphs-cubic and quartic structured vertices connected by structured &apos;'fermionic'&apos; or &apos;'bosonic'&apos; &apos;'particle'&apos; and &apos;'nonparticle'&apos; arcs. A Planck-scale path step determines the gravitational constant while controlling all graph structure. The basis of the theory&apos;s (zero-rest-mass) elementary-particle Hilbert space (which includes neither gravitons nor scalar bosons) resides in particle arcs. Nonparticle arcs within a path are responsible for energy and rest mass.

  1. Hawai&apos;i&apos;s EVolution: Hawai&apos;i Powered. Technology Driven. (Brochure)

    Energy Technology Data Exchange (ETDEWEB)

    2013-05-01

    This Hawaii Clean Energy Initiative (HCEI) brochure outlines Hawaii&apos;s energy and transportation goals and the implementation of electric vehicles (EV) and electric vehicle infrastructure since HCEI began in 2008. It includes information about Hawaii&apos;s role in leading the nation in available EV charging infrastructure per capita; challenges for continuing to implement EV technology; features on various successful EV users, including the Hawaiian Electric Company, Enterprise Rent-A-Car, and Senator Mike Gabbard; how EVs can integrate into and help propel Hawaii&apos;s evolving smart grid; and much more.

  2. Deep-sea drilling. Practical aspects of 4D seismic: what an engineer needs to know. Developments in Iran: &apos;SIRRI&apos; of the Total company and &apos;DOROOD&apos; of the Elf company. The &apos;DOROOD&apos; operating plan. The &apos;SIRRI&apos; operating plan; Le forage en eau profonde. Aspects pratiques de la sismique 4D: ce qu&apos;un ingenieur doit savoir. Developpements en Iran: &apos;SIRRI&apos; de Total et &apos;DOROOD&apos; d&apos;Elf. Le projet &apos;DOROOD&apos;. Le projet &apos;SIRRI&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Claverie, P. [Schlumberger Sedco Forex, 92 - Montrouge (France); Bauquis, P.R. [Association Francaise des Techniciens et Professionnels du Petrole, AFTP, 92 - Paris-la-Defense (France); Seiller, B.; Geronimi, X. [Elf France, (France); Barthe, D. [Total Fina, 92 - La Defense (France)

    1999-08-01

    In this &apos;Drilling-Production&apos; section, in which 7 papers are gathered, 3 main topics are developed: (1)the deep-sea drilling (2)the practical aspects of 4D seismic (3)the &apos;SIRRI&apos; and &apos;DOROOD&apos; operating plans in Iran. Concerning the first point, it can be noticed that nowadays, mobile platforms are located in great offshore where water depths are of about 2400 m. In the second point is particularly detailed what 4D is, what it can do, what the primary conditions for it works are and how it costs. The third point is the more particularly detailed in this section (15 pages). At first an introduction indicates why Iran has to call to international petroleum investors, what the current problems of Iran are, what Iran has to do to attract foreign investment and technology and what the challenges to foreign companies are. Then the two operating plans: &apos;SIRRI&apos; and &apos;DOROOD&apos; are exposed into details. A synthesis of these plans, called of &apos;Buy Back&apos;, (production, investment, refund) is given as well as their advantages and disadvantages. (O.M.)

  3. Tratamento nutricional dos transtornos alimentares Nutritional treatment of eating disorders

    Directory of Open Access Journals (Sweden)

    Andréa Romero Latterza

    2004-01-01

    Full Text Available Pacientes com transtornos alimentares possuem inadequações profundas no consumo, padrão e comportamento alimentar, além de diversas crenças equivocadas sobre alimentação, o que geralmente acarreta piora do estado nutricional. O tratamento nutricional visa a reverter tais alterações e promover hábitos alimentares saudáveis e melhor relação para com o alimento. Os objetivos e características do tratamento diferem para a anorexia nervosa e a bulimia nervosa, contudo, usualmente, a abordagem é dividida em duas fases: a educacional, cujas principais metas são a regularização do hábito alimentar e o aumento do conhecimento nutricional, e a experimental, que visa a propiciar maior reabilitação nutricional e mudanças mais profundas no comportamento alimentar. As evidências existentes sugerem que o tratamento nutricional promove a melhora de tais parâmetros, porém, alguns comportamentos alimentares, como a sensação de incompetência ao lidar com os alimentos, permanecem. Desta forma, mais estudos são necessários para que se possa de fato avaliar a eficácia da abordagem nutricional.Patients with eating disorders have disturbed food intake, food pattern, food behavior, and mistaken beliefs about food and nutrition, which can worsen nutritional status. The nutritional treatment aims to revert such alterations and to promote better food habits and relationship with food. The objectives and characteristics of the treatment are different for anorexia nervosa and bulimia nervosa, but usually the approach has two phases: the educational phase, whose major goals are regularization of food habits and increase of nutrition knowledge; and the experimental phase, whose targets are better nutritional rehabilitation and more complex improvements of nutritional behavior. Evidence suggests that nutritional treatment can ameliorate such parameters, but some inadequate food behaviors remain, such as feeling of incompetence while dealing with

  4. Câncer do colo de útero: efeitos do tratamento

    Directory of Open Access Journals (Sweden)

    Letícia Fernandez Frigo

    2015-12-01

    Full Text Available O Câncer incide sobre a população de forma avassaladora, em função da transição demográfica, bem como do aumento da exposição da população a agentes cancerígenos no meio ambiente. O câncer de colo de útero é a segunda neoplasia mais comum entre as mulheres. As modalidades terapêuticas, no decorrer de suas aplicações, levam a diversas disfunções uroginecológicas consequentes dos procedimentos cirúrgicos e demais terapias. Objetivo: investigar a ocorrência de disfunções uroginecológicas, após o tratamento do câncer de colo de útero. Método: a pesquisa desenvolvida foi do tipo, descritiva com abordagem quantitativa, sendo do tipo não probabilística acidental. Participaram da pesquisa nove mulheres no período climatérico, que realizaram tratamento do câncer do colo de útero cirúrgico ou conservador há, no máximo, cinco anos. Foi aplicado a ficha de avaliação e o inventário de satisfação sexual. Resultado: verificou-se, através dos dados, que a radioterapia foi o tratamento mais utilizado entre as participantes. Pode-se verificar que o Câncer de colo de útero acarreta algumas disfunções uroginecológica em mulheres portadoras desta patologia. Considerações finais: neste estudo, pode-se analisar os efeitos que o Câncer de colo de útero acarretou nas participantes desta pesquisa, ocasionando algumas disfunções como dispareunia, estenose, vaginismo, diminuição da lubrificação, incontinência urinária, incontinência fecal e linfedema.

  5. Novo tratamento para extenso granuloma paracoccidioidomicótico cerebral

    Directory of Open Access Journals (Sweden)

    Carlos A. M. Guerreiro

    1987-12-01

    Full Text Available Um paciente de 59 anos com grande granuloma paracoccidioidomicótico na região fronto-parietal direita submetido a tratamento com sulfametoxazol-trimetoprim apenas é apresentado. O paciente foi internado com história de crises epiléticas parciais motoras à esquerda secundariamente generalizadas há 4 meses, associadas a progressiva hemiparesia esquerda há 2 meses. O exame físico mostrou discreto descoramento da mucosa, diminuição de murmúrio vesicular e leve hepatomegalia. O exame neurológico revelou hemiparesia esquerda completa, predominando em membros superior, RX de crânio, exame do LCR e EEG mostraram-se normais. Tomografia computadorizada revelou grande área hipodensa na região fronto-parietal direita estendendo-se até o córtex; injeção do contraste acentuou a área central e mostrou formação de um anel ao redor da lesão. RX de tórax mostrou infiltrado pulmonar difuso e bilateral, mais proeminente nas regiões para-hilares, consistente com paracoccidiodomicose pulmonar. Exame do escarro mostrou a presença do Paracoccidioides brasiliensis. As crises epiléticas foram controladas com 100 mg de fenobarbital. Foi iniciado tratamento com 1200 mg de sulfametoxazole mais 240 mg de trimetoprim duas vezes ao dia. Uma semana após o início do tratamento começou a melhora da hemiparesia. Os controles tomográficos evidenciaram a regressão da lesão. Acompanhado por 26 meses, o paciente persiste assintomático usando 800 mg de sulfametoxazol e 160 mg de trimetoprim. Os autores discutem essa terapia para lesões extensas, até então considerada pela literatura consultada como de resolução cirúrgica e/ou pelo uso da anfotericina B.

  6. Cisto dentígero: modalidades de tratamento

    Directory of Open Access Journals (Sweden)

    Rubens Caliento

    Full Text Available INTRODUÇÃO: O cisto dentígero é o segundo cisto odontogênico mais frequente nos maxilares. É uma lesão benigna, derivada do epitélio odontogênico da coroa de um dente não erupcionado, porém de etiopatogenia incerta. São geralmente radiotransparentes e, mais comumente, uniloculares. Estas lesões são observadas em exames de rotina ou quando não ocorre o irrompimento de um dente permanente. Os terceiros molares inferiores e os caninos superiores são os dentes mais acometidos, sendo também alta a ocorrência desta lesão em dentes supranumerários e associados a odontomas. O cisto dentígero ocorre principalmente nas três primeiras décadas de vida, tendo um crescimento lento e assintomático; pode atingir dimensões consideráveis, causando deformidade facial, impactação e deslocamento de dentes e/ou estruturas adjacentes. OBJETIVO: Definição das técnicas de marsupialização e enucleação, bem como consideração de critérios objetivos importantes para o plano de tratamento, como tamanho do cisto, idade, proximidade com estruturas anatômicas e importância clínica do dente envolvido. Apesar das peculiaridades clínicas de cada caso e do método de tratamento escolhido, o prognóstico destas lesões é favorável, quando se emprega apropriada terapêutica. MATERIAL E MÉTODO: O presente estudo apresentará um relato de caso tratado através da manobra de descompressão seguida de enucleação, bem como uma discussão acerca das modalidades de tratamento. RESULTADO: O paciente encontra-se em pós-operatório de dois anos sem sinais de recidiva da lesão e ausência de parestesias em face. CONCLUSÃO: A técnica empregada preservou a função neurossensorial e mostrou-se eficiente para a cura da lesão.

  7. Retro-odontoid &apos;'ghost'&apos; pseudotumours in atlanto-axial instability caused by rheumatoid arthritis

    Energy Technology Data Exchange (ETDEWEB)

    Kenez, J. (Dept. of Neurology, Semmelweis Medical Univ., Budapest (Hungary)); Turoczy, L. (Dept. of Neurosurgery, National Inst. of Traumatology, Budapest (Hungary)); Barsi, P. (Dept. of Neurology, Semmelweis Medical Univ., Budapest (Hungary)); Veres, R. (Dept. of Neurosurgery, National Inst. of Traumatology, Budapest (Hungary))

    1993-05-01

    Among 27 cases of marked atlanto-axial instability investigated in the last 10 years we found three with reducible dislocation, in which a cystic &apos;ghost&apos; pseudo-tumours appeared behind the odontoid, maintaining cord compression even in the reduced position, thus influencing the strategy of operative treatment. The cervical spine and the craniocervical region were examined by conventional tomogrpaphy, myelotomography, CT, CT myelography (following melography), and recently in some cases with MRI. (orig./UWA)

  8. Continuous process of powder production for MOX fuel fabrication according to &apos;'granat'&apos; technology

    Energy Technology Data Exchange (ETDEWEB)

    Morkovnikov, V.E.; Raginskiy, L.S.; Pavlinov, A.P.; Chernov, V.A.; Revyakin, V.V.; Varykhanov, V.S.; Revnov, V.N. [SSC RF, A.A. Bochvar All-Russia, Research Institute of Inorganic Materials, VNIINM (Russian Federation)

    2000-07-01

    During last years the problem of commercial MOX fuel fabrication for nuclear reactors in Russia was solved in a number of directions. The paper deals with the solution of the problem of creating a continuous pilot plant for the production of MOX fuel powders on the basis of the home technology &apos;Granat&apos;, that was tested before on a small-scale pilot-commercial batch-operated plant of the same name and confirmed good results. (authors)

  9. Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment.

    Science.gov (United States)

    Salomon-Zimri, Shiran; Glat, Micaela Johanna; Barhum, Yael; Luz, Ishai; Boehm-Cagan, Anat; Liraz, Ori; Ben-Zur, Tali; Offen, Daniel; Michaelson, Daniel M

    2016-06-30

    Apolipoprotein E4 (ApoE4), the most prevalent genetic risk factor for Alzheimer's disease (AD), is associated with increased neurodegeneration and vascular impairments. Vascular endothelial growth factor (VEGF), originally described as a key angiogenic factor, has recently been shown to play a crucial role in the nervous system. The objective of this research is to examine the role of VEGF in mediating the apoE4-driven pathologies. We show that hippocampal VEGF levels are lower in apoE4 targeted replacement mice compared to the corresponding apoE3 mice. This effect was accompanied by a specific decrease in both VEGF receptor-2 and HIF1-α. We next set to examine whether upregulation of VEGF can reverse apoE4-driven pathologies, namely the accumulation of hyperphosphorylated tau (AT8) and Aβ42, and reduced levels of the pre-synaptic marker, VGluT1, and of the ApoE receptor, ApoER2. This was first performed utilizing intra-hippocampal injection of VEGF-expressing-lentivirus (LV-VEGF). This revealed that LV-VEGF treatment reversed the apoE4-driven cognitive deficits and synaptic pathologies. The levels of Aβ42 and AT8, however, were increased in apoE3 mice, masking any potential effects of this treatment on the apoE4 mice. Follow-up experiments utilizing VEGF-expressing adeno-associated-virus (AAV-VEGF), which expresses VEGF specifically under the GFAP astrocytic promoter, prevented this effects on apoE3 mice, and reversed the apoE4-related increase in Aβ42 and AT8. Taken together, these results suggest that apoE4-driven pathologies are mediated by a VEGF-dependent pathway, resulting in cognitive impairments and brain pathology. These animal model findings suggest that the VEGF system is a promising target for the treatment of apoE4 carriers in AD.

  10. What does the APO mean?

    Directory of Open Access Journals (Sweden)

    Yafei Wang

    2016-10-01

    Full Text Available The Asian–Pacific Oscillation (APO is a relatively new teleconnection index and a number of peer-reviewed studies have confirmed its’ existence. This study reexamines the concept of the APO teleconnection as currently published in the literature. Most results have found that this pattern could be defined as its own teleconnection pattern within the Pacific Ocean Basin. This work demonstrates that the APO is inevitably associated with an additional action centre located over the North Atlantic Ocean, and the index can be extended. Previous studies have used a variety of methods to represent the APO, and a method is proposed here to standardise the formulation. It is argued that the extended index proposed here provides a more robust result. The APO typically is identified using the eddy temperature rather than geopotential height as the source material for its construction, as geopotential could not adequately represent this teleconnection pattern. This leads to a discussion regarding the basic criterion for defining teleconnective activity within the extratropical regions. We also identify other problems in the current understanding of APO theory that need to be addressed.

  11. Calculation of LDL apoB

    NARCIS (Netherlands)

    Sniderman, A.D.; Tremblay, A.J.; Graaf, J. de; Couture, P.

    2014-01-01

    OBJECTIVES: This study tests the validity of the Hattori formula to calculate LDL apoB based on plasma lipids and total apoB. METHODS: In 2178 patients in a tertiary care lipid clinic, LDL apoB calculated as suggested by Hattori et al. was compared to directly measured LDL apoB isolated by ultracent

  12. smesh User&apos;s Guide

    Energy Technology Data Exchange (ETDEWEB)

    Chand, K K

    2003-05-05

    &apos;'smesh'&apos; is a general purpose, interactive, 2D unstructured mesh generator based on Overture. It supports three kinds of mesh generation techniques: structured patches with transfinite interpolation (TFI); unstructured triangles based on an advancing front technique; and a Cartesian cutcell/triangle hybrid method. Meshes are generated in a generalized &apos;'multi-block'&apos; manner where each &apos;'block'&apos;, or region, can be one of the three mesh types. Geometry definitions can be created interactively by placing points and interpolating curves. Spacing information is provided by both the curve discretization (which can be stretched) and a user specified preferred grid spacing for a region. A mesh optimization procedure is available for the non-TFI regions for mesh quality improvement. Each mesh region is given an unique identifier and an optional string name. Meshes are exported to a modified &apos;'ingrid'&apos; format including mesh region identifiers and names. Facilities for command scripting and batch running are available.

  13. Performance of &apos;'ductless'&apos; personalized ventilation in conjunction with displacement ventilation: Impact of disturbances due to walking person(s)

    Energy Technology Data Exchange (ETDEWEB)

    Halvonova, Barbora [Department of Building Services, Slovak University of Technology in Bratislava, 813 68 Bratislava (Slovakia); International Centre for Indoor Environment and Energy, Department of Civil Engineering, Technical University of Denmark (Denmark); Melikov, Arsen K. [International Centre for Indoor Environment and Energy, Department of Civil Engineering, Technical University of Denmark (Denmark)

    2010-02-15

    The performance of the novel &apos;'ductless'&apos; personalized ventilation in conjunction with displacement ventilation (DV) was compared with the performance of DV alone under realistic conditions involving disturbances due to walking of one or two persons. An office room with two workstations was arranged in a full-scale test room. Two thermal manikins were used as sedentary occupants at the workstations. Two pollution sources, namely exhaled air by one of the manikins and passive pollution on the table in front of the same manikin were simulated. The performance of the ventilation systems was evaluated with regard to the quality of inhaled air and thermal comfort of the seated &apos;'occupants'&apos;. The walking person(s) caused mixing of the clean and cool air near the floor with the polluted and warmer air at higher levels and disturbed the displacement principle which resulted in a decrease of the inhaled air quality. The performance of the &apos;'ductless'&apos; PV under the tested conditions was better as opposed to DV alone. Thus in practice the &apos;'ductless'&apos; PV will be superior to DV alone as regards perceived quality of inhaled air. The location of a walking person was found to be important. Person(s) walking close to the displacement diffuser will cause greater disturbance. (author)

  14. The generation and function of soluble apoE receptors in the CNS

    Directory of Open Access Journals (Sweden)

    Rebeck G William

    2006-10-01

    Full Text Available Abstract More than a decade has passed since apolipoprotein E4 (APOE-ε4 was identified as a primary risk factor for Alzheimer 's disease (AD, yet researchers are even now struggling to understand how the apolipoprotein system integrates into the puzzle of AD etiology. The specific pathological actions of apoE4, methods of modulating apolipoprotein E4-associated risk, and possible roles of apoE in normal synaptic function are still being debated. These critical questions will never be fully answered without a complete understanding of the life cycle of the apolipoprotein receptors that mediate the uptake, signaling, and degradation of apoE. The present review will focus on apoE receptors as modulators of apoE actions and, in particular, explore the functions of soluble apoE receptors, a field almost entirely overlooked until now.

  15. Tratamento superficial dos agregados reciclados de RCD com hidrofugantes.

    OpenAIRE

    Winnie Franco Santos

    2016-01-01

    A proposta busca reduzir a absorção de água dos agregados reciclados de Resíduos de Construção e Demolição (RCD), através do tratamento de sua superfície com hidrofugante, de maneira que estes não aumentem o consumo de água tampouco reduzam a resistência mecânica. Os agregados reciclados de RCD foram caracterizados quanto à granulometria, morfologia, porosidade, ângulo de contato aparente, absorção de água, análise de imagem e rugosidade superficial. Em seguida, os mesmos foram tratados super...

  16. Consenso para o tratamento nutricional de fenilcetonúria

    OpenAIRE

    Ferreira de Almeida, Manuela

    2014-01-01

    Resumo: A fenilcetonúria é uma doença hereditária do metabolismo das proteínas. Em cerca de 98% dos indivíduos afectados, a elevação da concentração da fenilalanina plasmática fica a dever-se ao défice hepático da enzima hidroxílase da fenilalanina. O diagnóstico precoce da doença, realizado pela detecção do aumento da concentração plasmática da fenilalanina, constitui o meio mais eficaz para a rápida implementação do tratamento, de modo a evitar a instalação das sequelas neurológicas. O trat...

  17. O tratamento do pé artrogripótico

    OpenAIRE

    2008-01-01

    A artrogripose é um termo utilizado para definir a presença, ao nascimento, de múltiplas contraturas articulares. A amioplasia é a principal e mais freqüente doença que cursa com contraturas congênitas e deformidade em eqüinovaro dos pés. A maioria dessas crianças tem bom potencial para a deambulação, havendo a necessidade da correção da deformidade dos pés para a posição plantígrada. O tratamento desses pés continua sendo um desafio devido à rigidez característica da doença e ao alto risco d...

  18. Dieta cetogênica no tratamento de epilepsias farmacorresistentes

    OpenAIRE

    Nonino-Borges,Carla Barbosa; Bustamante,Vera Cristina Terra; Rabito,Estela Iraci; Inuzuka,Luciana Midoro; Sakamoto,Américo Ceike; Marchini, Júlio Sérgio

    2004-01-01

    A epilepsia é uma condição clínica crônica correspondente a um grupo de doenças que tem em comum crises epilépticas; ela atinge de 0,5% a 1,0% da população dos países desenvolvidos, podendo esta prevalência ser maior nos países em desenvolvimento. Aproximadamente um terço dos pacientes evolui com crises epilépticas intratáveis com medicamentos; em alguns casos, é possível o tratamento cirúrgico. Nos pacientes em que cirurgia não é possível, a dieta cetogênica passa a ser uma opção terapêutica...

  19. Tratamento Videolaparoscópico de Endometriomas Ovarianos

    Directory of Open Access Journals (Sweden)

    Lopez Adriana C.S.

    2000-01-01

    Full Text Available Objetivo: avaliar os resultados do tratamento videolaparoscópico de 32 pacientes com endometrioma ovariano. Métodos: estudo retrospectivo que incluiu trinta e duas pacientes encaminhadas ao setor de Endoscopia Ginecológica do Serviço de Ginecologia e Obstetrícia do Hospital do Servidor Público Estadual "Francisco Morato de Oliveira" - São Paulo, as quais tinham diagnóstico clínico e ultra-sonográfico de endometrioma ovariano e foram tratadas por videolaparoscopia. Onze pacientes com endometriomas com diâmetro menor que 3 cm foram submetidas à drenagem do endometrioma e exérese da cápsula na primeira laparoscopia. Vinte e uma pacientes com endometriomas com diâmetros maior que 3 cm foram submetidas à drenagem do endometrioma e lavagem do cisto na primeira laparoscopia. A seguir, utilizaram análogo do GnRH por quatro meses (1 ampola mensal e então foram submetidas à segunda laparoscopia para retirada da cápsula do endometrioma. O exame histopatológico do material obtido na cirurgia foi realizado em todos os casos. Avaliou-se o resultado imediato do procedimento e a freqüência de recidivas. Resultados: não se registraram intercorrências cirúrgicas ou complicações pós-operatórias. Ocorreram três recidivas em um período de seis a doze meses, todas no grupo de 21 pacientes com endometriomas com o diâmetro maior que 3 cm. Conclusão: o tratamento videolaparoscópico dos endometriomas ovarianos com retirada da cápsula apresenta bons resultados e baixo índice de recidiva.

  20. Tratamento nutricional da bulimia nervosa Nutritional therapy for bulimia nervosa

    Directory of Open Access Journals (Sweden)

    Marle dos Santos Alvarenga

    2010-10-01

    Full Text Available A bulimia nervosa é um transtorno alimentar caracterizado por compulsões alimentares e métodos compen-satórios recorrentes. Os pacientes apresentam ingestão alimentar inadequada e comportamentos alimentares disfuncionais. O adequado tratamento do transtorno requer uma equipe multiprofissional e terapia nutricional especializada. Compreender as características desse transtorno, os padrões de consumo e o comportamento alimentar, bem como atentar para as atitudes alimentares dos pacientes, é fundamental para o planejamento e para a adequada condução da abordagem nutricional. A terapia nutricional para esse transtorno é diferenciada, exigindo do nutricionista maiores habilidades de aconselhamento nutricional. Educação nutricional e acon-selhamento nutricional, com ênfase na abordagem de atitudes alimentares e insatisfação corporal, são o foco da terapia nutricional. Para o atendimento eficaz desses pacientes e o sucesso no tratamento nutricional, é importante que o profissional se mantenha atualizado sobre nutrição e transtornos alimentares e procure especialização e experiência nessa área do conhecimento.Bulimia nervosa is an eating disorder characterized by binge eating and compensatory behaviors. The patients present inappropriate food intake and dysfunctional eating behaviors. Proper treatment of this disorder requires a multidisciplinary team and specialized nutrition therapy. It is fundamental to understand the characteristics of this disorder, the intake patterns and the eating behavior, and be attentive to the eating attitudes of these patients to plan and conduct a nutritional approach properly. The nutrition therapy for this disorder is specific and demands greater skillfulness in nutrition counseling from the dietician. Nutrition therapy focuses on nutrition education and nutrition counseling, mainly addressing eating attitudes and dissatisfaction with body image. The professional must keep abreast on nutrition and

  1. Tratamento cirúrgico da retinopatia diabética

    Directory of Open Access Journals (Sweden)

    Nelson Alexandre Sabrosa

    2013-06-01

    Full Text Available A retinopatia diabética é a causa mais frequente de cegueira na população ativa nos países desenvolvidos. A prevalência da retinopatia diabética aumenta com a duração da diabetes, e praticamente 100% dos pacientes com diabetes tipo I (DM I e mais do que 60% dos pacientes com o tipo II (DM II apresentarão algum sinal de retinopatia após 20 anos. Além de um controle sistêmico rigoroso dos níveis glicêmicos, lipídicos, colesterol e da pressão arterial, o exame oftalmológico de rotina, com a identificação precoce da retinopatia diabética, podem detectar anormalidades em estágios primários, o que possibilita o tratamento ainda na fase inicial do problema; o uso adequado da fotocoagulação e a utilização da terapia antiangiogênica pode reduzir o número de pacientes com hemorragia vítrea ou descolamento tracional da retina. Infelizmente, em vários pacientes, a retinopatia progride mesmo com as melhores condutas tomadas pelo paciente e pelo oftalmologista, embora vários olhos podem se beneficiar com o tratamento cirúrgico, a vitrectomia posterior via pars plana. Esta revisão apresenta as indicações atuais para cirurgia vitreorretiniana em pacientes portadores de retinopatia diabética proliferativa.

  2. Tratamento da doença de Parkinson

    Directory of Open Access Journals (Sweden)

    Francisco Cardoso

    1995-03-01

    Full Text Available Doença de Parkinson (DP é a causa mais freqüente de parkinsonismo em nosso meio, responsável por 58% dos casos. Devem-se excluir outras causas, como uso de drogas antidopaminérgicas (20% dos casos. Levodopa é o agente mais importante para o tratamento de DP. Há controvérsia sobre quando se introduzir esta droga mas deve-se reservá-la para quando surgir substancial comprometimento funcional. Drogas acessórias são anticolinérgicos, úteis para o tremor; amantadina, para bradicinesia e rigidez; e agonistas dopaminérgicos que ajudam no manuseio de complicações da levodopa. A selegelina tem discreta ação sintomática e possível ação neuroprotetora. O tratamento de DP pode ser complicado por falha primária, falha secundária e problemas do uso da levodopa. A falha primária pode ser causada por uso de agentes antidopaminérgicos, presença de tremor de repouso severo ou erro diagnóstico. A causa mais comum de falha secundária é progressão da DP. As principais complicações do uso da levodopa são flutuações e discinesias. Outros problemas comuns são disautonomia, depressão, psicose e demência. Fenomenologia e manuseio destas complicações são discutidos. Perspectivas futuras incluem cirurgias para reversão de patologia.

  3. The synchro crusher: a new type of impact?; Le &apos;'synchro-concasseur'&apos;: du nouveau dans l&apos;impact?

    Energy Technology Data Exchange (ETDEWEB)

    Van der Zanden, H.; Valenchon, P.

    1999-10-01

    The seminar organized by &apos;Quarry Management&apos; on the occasion of the Hillhead 99 workshop provided the Dutch company VanderZanden with the opportunity to present its research work on the development of a new concept of crushing called &apos;SynchroCrusher&apos;. Its principle uses the &apos;relative movement&apos; linked with &apos;synchronization&apos;. Each particle is uniformly and precisely crushed by a double impact, the second impact being only generated by the residual (free) energy and occurring at a greater speed. An optimal direct impact is obtained thanks to a perfect control of the impact angle (between 75 and 85 deg.) and of the particle trajectories with no interference between particles. This system allows to reduce both the energy consumption and the wear of crushers. This paper presents the concept of the SynchroCrusher, its comparison with other classical impact crushers and the R and D work carried out to analyze the movement of particles, the capacity of the crusher with respect to the orientation of blades, the directional changes of particles inside the crusher and the synchronization of particle trajectories. (J.S.)

  4. Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice.

    Science.gov (United States)

    Klein, Rebecca C; Acheson, Shawn K; Mace, Brian E; Sullivan, Patrick M; Moore, Scott D

    2014-09-01

    The human APOE4 allele is associated with an early age of onset and increased risk of Alzheimer's disease (AD). Apolipoprotein E is secreted as part of a high-density lipoprotein-like particle by glial cells in the brain for the primary purpose of transport of lipophilic compounds involved in the maintenance of synapses. Previous studies examining synaptic integrity in the amygdala of human apoE targeted replacement (TR) mice showed a decrease in spontaneous excitatory synaptic activity, dendritic arbor, and spine density associated with apoE4 compared with apoE3 and apoE2 in adult male mice. In the present study, we assessed how APOE genotype affects synaptic integrity of amygdala neurons by comparing electrophysiological and morphometric properties in human apoE3, E4, and E2/4 TR mice at the age of 18-20 months. In contrast to adult mice, we found that aged apoE4 TR mice exhibited the highest level of excitatory synaptic activity compared with other cohorts. Additionally, apoE4 mice had significantly greater spontaneous inhibitory activity than all other cohorts. Taken together, there was a significant interaction between genotypes when comparing inhibition relative to excitation; there was a simple main effect of frequency type with an imbalance toward inhibition in apoE4 mice but not in apoE3 or apoE2/4 mice. These results suggest that apoE isoforms differentially influence synaptic transmission throughout the life span, where aging coupled with apoE4 expression, results in an imbalance in maintaining integrity of synaptic transmission.

  5. Why Germany&apos;s &apos;Messy&apos; energy transition should be a lesson to other nations

    Energy Technology Data Exchange (ETDEWEB)

    Shepherd, John [nuclear 24, Brighton (United Kingdom)

    2015-03-15

    Germany&apos;s so-called &apos;&apos;energy transition&apos;&apos; (&apos;'Energiewende'&apos;) is increasingly drawing the intention of the international community - but it seems for all the wrong reasons. US Senator Lamar Alexander said recently that German energy policy is one of the reasons the US should not abandon nuclear, but actually encourage increased investment in nuclear power plants. Alexander&apos;s remarks were made in an article published by the US Nuclear Energy Institute, in which he outlined his reasons why the US should not follow Germany&apos;s lead. Alexander rightly pointed out that the cost of attempting to replace nuclear power with wind, solar, and accompanying infrastructure is estimated by the German government at some 1.2 trillion US dollars (about 1 trillion Euros). The senator also made the point that Germany &apos;&apos;does not produce enough reliable, baseload energy for an important manufacturing economy&apos;&apos;. He also expressed concern at Germany&apos;s reliance on buying natural gas from Russia. While Germany has been forcing the closure of nuclear power plants others, including the oil-rich United Arab Emirates (UAE), have been investing in new nuclear, Alexander said. Judging from Alexander&apos;s remarks, it seems that Germany&apos;s energy transition experience will, after all, have a long-lasting legacy. That legacy will be a valuable lesson to other major industrialised nations in why they should not follow Germany&apos;s lead in abandoning a sensible energy mix, if they wish to maintain and develop economic and industrial productivity while keeping to international commitments to tackle climate change.

  6. A Survey of Open Clusters in the u&apos;g'r'i'z&apos; Filter System. 3. Results for the Cluster NGC 188

    Energy Technology Data Exchange (ETDEWEB)

    Fornal, Bartosz; Tucker, Douglas L.; Smith, J.Allyn; Allam, Sahar S.; Rider, Cristin J.; Sung, Hwankyung; /Jagiellonian U. /Fermilab /Austin Peay State U. /Wyoming U. /Johns Hopkins U. /Sejong U.

    2006-11-01

    The authors continue the series of papers describing the results of a photometric survey of open star clusters, primarily in the southern hemisphere, taken in the u&apos;g'r'i'z&apos; filter system. The entire observed sample covered more than 100 clusters, but here they present data only on NGC 188, which is one of the oldest open clusters known in the Milky Way. They fit the Padova theoretical isochrones to the data. Assuming a solar metallicity for NGC 188, they find a distance of 1700 {+-} 100 pc, an age of 7.5 {+-} 0.7 Gyr, and a reddening E(B-V) of 0.025 {+-} 0.005. This yields a distance modulus of 11.23 {+-} 0.14.

  7. Energy and the new class. [Assault of &apos;&apos;new breed&apos;&apos; of American on established institutions

    Energy Technology Data Exchange (ETDEWEB)

    King, L.

    1979-03-14

    The bounty of the US is taken for granted by its population. Nowhere is this misvaluation of a society and its benefits more evident than in the energy industries. But energy represents a tool by which society can be shaped; a device by which the standared of living and the very nature of the national lifestyle can be controlled, modified, amplified, or reduced. Two examples examined to show how energy shapes social order and human life are the women&apos;s movement and the desire to live in the Sunbelt. Five phenomena are then examined to point out the desire to restrain the nation&apos;s rampant pursuit of a higher standard of living, as opposed to the more subjective and seemingly more desirable goal of a better quality of life: the civil rights movement; the environmental movement; the Vietnam War; the Watergate scandal; and the assumption that prosperity at today&apos;s level is irreducible, concrete, and not subject to diminution. The &apos;&apos;new class&apos;&apos; is essentially made up of those educated in the liberal arts, divorced from an understanding of the mechanics of free-enterprise institutions and of the sicences. The antagonistic view of the new class of corporations and its assault on established institutions are noted. Energy companies are frustrated in telling their story, but the story that must be told is not the story of how excellently the energy sector has performed, but the story of how a new breed of Americans is seeking to remake America in its own image without the rest being aware of what is going on. (MCW)

  8. The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice.

    Directory of Open Access Journals (Sweden)

    Carola I F Janssen

    Full Text Available Apolipoprotein E4 (ApoE4, one of three common isoforms of ApoE, is a major risk factor for late-onset Alzheimer disease (AD. ApoE-deficient mice, as well as mice expressing human ApoE4, display impaired learning and memory functions and signs of neurodegeneration. Moreover, ApoE protects against high-fat (HF diet induced neurodegeneration by its role in the maintenance of the integrity of the blood-brain barrier. The influence of a HF diet on the progression of AD-like cognitive and neuropathological changes was assessed in wild-type (WT, human ApoE4 and ApoE-knockout (ApoE-/- mice to evaluate the modulatory role of ApoE in this process. From 12 months of age, female WT, ApoE4, and ApoE-/- mice were fed either a standard or a HF diet (19% butter, 0.5% cholate, 1.25% cholesterol throughout life. At 15 months of age mice performed the Morris water maze, evaluating spatial learning and memory. ApoE-/- showed increased spatial learning compared to WT mice (p = 0.009. HF diet improved spatial learning in WT mice (p = 0.045, but did not affect ApoE4 and ApoE-/- mice. Immunohistochemical analyses of the hippocampus demonstrated increased neuroinflammation (CD68 in the cornu ammonis 1 (CA1 region in ApoE4 (p = 0.001 and in ApoE-/- (p = 0.032 mice on standard diet. HF diet tended to increase CD68 in the CA1 in WT mice (p = 0.052, while it decreased in ApoE4 (p = 0.009, but ApoE-/- remained unaffected. A trend towards increased neurogenesis (DCX was found in both ApoE4 (p = 0.052 and ApoE-/- mice (p = 0.068. In conclusion, these data suggest that HF intake induces different effects in WT mice compared to ApoE4 and ApoE-/- with respect to markers for cognition and neurodegeneration. We propose that HF intake inhibits the compensatory mechanisms of neuroinflammation and neurogenesis in aged female ApoE4 and ApoE-/- mice.

  9. Reflection group on &apos;Expert Culture&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Eggermont, G

    2000-07-01

    As part of SCK-CEN&apos;s social sciences and humanities programme, a reflection group on &apos;Expert Culture&apos; was established. The objectives of the reflection group are: (1) to clarify the role of SCK-CEN experts; (2) to clarify the new role of expertise in the evolving context of risk society; (3) to confront external views and internal SCK-CEN experiences on expert culture; (4) to improve trust building of experts and credibility of SCK-CEN as a nuclear actor in society; (5) to develop a draft for a deontological code; (6) to integrate the approach in training on assertivity and communication; (7) to create an output for a topical day on the subject of expert culture. The programme, achievements and perspectives of the refection group are summarised.

  10. Outline of year-round ski facility &apos;LALAPORT SKI DOME &apos;SSAWS'&apos;. Lalaport ski dome &apos;SSAWS&apos; no keikaku gaiyo

    Energy Technology Data Exchange (ETDEWEB)

    Kayo, M. (Kajima Corp., Tokyo (Japan)); Suzuki, T. (NKK Corp., Tokyo (Japan))

    1994-03-31

    This paper introduces the world&apos;s first indoor snow-fall type artificial ski facility &apos;SSAWS&apos;. Skiing can be enjoyed throughout a year by virtue of artificial snow making machines. Snow quality control requires that the temperature in the ski slope be kept below the freezing point at all times. Means to achieve the requirement included reducing outer wall load by using heat insulation, recovering waste heat from the ski slope by using heat pipes, preventing cold air from leaking and outside air from entering, and adopting a cogeneration system. The cold heat source is a warm water absorbing freezer utilizing waste heat from a gas engine for the cogeneration. The cogeneration system has saved more than 60% of the air conditioning and hot water supplying energy, reducing the annual expense by 15%. The snow making system has a nozzle jet out very highly homogeneous and microfine water droplets with compressed air, and freeze them at -5[degree]C utilizing adiabatic expansion into snow to fall on the slope. The system can control the snow quality as required. The floor of the ski slope is in contact with atmosphere, where snow melting progresses from the lower part as a result of temperature gradient. Therefore, neither special heat source is required, nor a work to scrape and remove the snow that has been stained. 4 refs., 11 figs.

  11. &apos;&apos;Rio+20 on site&apos;&apos;. Communities on their way to sustainability. Examples from Germany; &apos;&apos;Rio+20 vor Ort&apos;&apos;. Kommunen auf dem Weg zur Nachhaltigkeit. Beispiele aus Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Nolting, Katrin; Goell, Edgar

    2012-03-15

    20 years ago, the international community adopted the concept of &apos;sustainable development&apos; as a model for the 21st century adopted in order to meet the growing challenges facing the mankind. With Agenda 21, the UN presented a global action plan for the implementation of such a sustainable development. This brochure provides an insight into sustainability activities at local level in Germany. It is shown how such activities result in future-oriented and exemplary developments in some areas and selected areas of action.

  12. &apos;Biomoleculas&apos;: cellular metabolism didactic software

    Energy Technology Data Exchange (ETDEWEB)

    Menghi, M L [Chair of Physiology and Biophysics, Facultad de Ingenieria, Universidad Nacional de Entre Rios, CC 57 Suc 3, Parana 3100, Entre Rios (Argentina); Novella, L P [Chair of Physiology and Biophysics, Facultad de Ingenieria, Universidad Nacional de Entre Rios, CC 57 Suc 3, Parana 3100, Entre Rios (Argentina); Siebenlist, M R [Chair of Physiology and Biophysics, Facultad de Ingenieria, Universidad Nacional de Entre Rios, CC 57 Suc 3, Parana 3100, Entre Rios (Argentina)

    2007-11-15

    &apos;Biomoleculas&apos; is a software that deals with topics such as the digestion, cellular metabolism and excretion of nutrients. It is a pleasant, simple and didactic guide, made by and for students. In this program, each biomolecule (carbohydrates, lipids and proteins) is accompanied until its degradation and assimilation by crossing and interrelating the different metabolic channels to finally show the destination of the different metabolites formed and the way in which these are excreted. It is used at present as a teaching-learning process tool by the chair of Physiology and Biophysics at the Facultad de Ingenieria - Universidad Nacional de Entre Rios.

  13. Intelligent marketing of electricity from decentral power sources. Project results of the research project &apos;'Massig'&apos;; Intelligente Vermarktung von Strom aus dezentralen Energiequellen. Projektergebnisse des Forschungsvorhabens &apos;'Massig'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Erge, Thomas; Sauer, Christian [Fraunhofer-Institut fuer Solare Energiesysteme ISE, Freiburg (Germany); Barnsteiner, Martin; Preiser, Klaus [Badenova Waermeplus GmbH und Co.KG, Freiburg (Germany)

    2011-07-01

    In the European research project &apos;Market Access for Smaller Size Intelligent Electricity Generation (Massig)&apos; scientists at the Fraunhofer Institute for Solar Energy Systems (Freiburg, Federal Republic of Germany) examined together with project partners the demand-oriented supply and commercialization of electricity from decentral power generators at the liberalized electricity market. The project team selected target countries and evaluated innovative solutions of marketing especially for specific applications of practice. Such a model project is that of Badenova Waermeplus GmbH (Freiburg, Federal Republic of Germany).

  14. An exercise in &apos;anhomomorphic logic&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Sorkin, Rafael D [Perimeter Institute, 31 Caroline Street North, Waterloo ON, N2L 2Y5 (Canada); Department of Physics, Syracuse University, Syracuse, NY 13244-1130 (United States)

    2007-05-15

    A classical logic exhibits a threefold inner structure comprising an algebra of propositions U, a space of &apos;truth values&apos; V, and a distinguished family of mappings {phi} from propositions to truth values. Classically U is a Boolean algebra, V = Z{sub 2}, and the admissible maps {phi}: U Z{sub 2} are homomorphisms. If one admits a larger set of maps, one obtains an anhomomorphic logic that seems better suited to quantal reality (and the needs of quantum gravity). I explain these ideas and illustrate them with three simple examples.

  15. The effects of the apoE4 genotype on the developing mouse retina.

    Science.gov (United States)

    Maharshak, Idit; Salomon-Zimri, Shiran; Antes, Ran; Liraz, Ori; Nisgav, Yael; Livnat, Tami; Weinberger, Dov; Colton, Carol A; Solomon, Arieh S; Michaelson, Daniel M

    2016-04-01

    Apolipoprotein E4 (apoE4), the most prevalent genetic risk factor for Alzheimer's disease (AD), is associated with neuronal and vascular impairments. The retina, which is as an extension of the central nervous system (CNS), is a particularly suitable model for studying developmental and functional aspects of the neuronal and vascular systems. This study investigates the apoE4-dependent developmental effects on the retinal vasculature and neuronal systems and on the levels of apoE and the vascular endothelial growth factor (VEGF) in the retina. This was performed utilizing retinas of 4, 7, 12, and of 120-day-old human-apoE4-targeted replacement mice and of corresponding mice that express the AD benign isoform, apoE3. The results obtained revealed retinal vascular pathology in the apoE4 mice, which started on the early post-natal days. This includes transient increase in vascular branching, and vascular buds which are round vascular elements representing sprouting or retracting vessels. These effects peaked and ended during the neonatal period. Examination of the synaptic system utilizing the pre-synaptic marker synaptophysin revealed a significant decrease of retinal synaptic density in the apoE4 mice, which was detectable by post-natal day 12 (P12). These morphological changes are associated with neonatal age-dependent elevation in the apoE levels in both apoE3 and apoE4 retinas which is more profound in the apoE4 mice and a corresponding increase in VEGF levels, which is less profound in the apoE4 mice. Additionally, we observed lower levels of retinal VEGF in the apoE4 mice compared to the apoE3 mice retinas on P12. These results show that apoE4 has a transient vascular effect during retinal development that ends in the neonatal period, which is accompanied by a synaptic effect that begins at the end of the neonatal period. These findings show that the apoE4 genotype can have distinct developmental effects on both the retinal vasculature and on neurons and

  16. Hemorrhage associated with &apos;bone crisis&apos; in Gaucher&apos;s disease identified by magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Horev, G.; Kornreich, L. (TA Univ., Petach-Tikva (Israel). Dept. of Pediatric Radiology); Hadar, H. (TA Univ., Petach-Tikva (Israel). Dept. of Radiology); Katz, K. (TA Univ., Petach-Tikva (Israel). Dept. of Pediatric Orthopedics)

    1991-10-01

    Children suffering from Gaucher&apos;s disease were examined by magnetic resonance imaging (MRI) during a characteristic episode of &apos;bone crisis&apos;. An unexpectedly high intramedullary as well as subperiosteal signal was observed on both the T1- and T2-weighted sequences in 5 patients, suggesting a subacute hemorrhage or hematoma. It is conceivable that such a painful hemorrhage is an important component of the &apos;bone crisis&apos; phenomenon. Furthermore, in these cases this is a specific sign which may enable differentiation of bone crises from other types of bone pain associated with Gaucher&apos;s disease. (orig.).

  17. ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations.

    Directory of Open Access Journals (Sweden)

    Benfeard Williams

    2015-10-01

    Full Text Available The increased risk of developing Alzheimer's disease (AD is associated with the APOE gene, which encodes for three variants of Apolipoprotein E, namely E2, E3, E4, differing only by two amino acids at positions 112 and 158. ApoE4 is known to be the strongest risk factor for AD onset, while ApoE3 and ApoE2 are considered to be the AD-neutral and AD-protective isoforms, respectively. It has been hypothesized that the ApoE isoforms may contribute to the development of AD by modifying the homeostasis of ApoE physiological partners and AD-related proteins in an isoform-specific fashion. Here we find that, despite the high sequence similarity among the three ApoE variants, only ApoE4 exhibits a misfolded intermediate state characterized by isoform-specific domain-domain interactions in molecular dynamics simulations. The existence of an ApoE4-specific intermediate state can contribute to the onset of AD by altering multiple cellular pathways involved in ApoE-dependent lipid transport efficiency or in AD-related protein aggregation and clearance. We present what we believe to be the first structural model of an ApoE4 misfolded intermediate state, which may serve to elucidate the molecular mechanism underlying the role of ApoE4 in AD pathogenesis. The knowledge of the structure for the ApoE4 folding intermediate provides a new platform for the rational design of alternative therapeutic strategies to fight AD.

  18. ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations.

    Science.gov (United States)

    Williams, Benfeard; Convertino, Marino; Das, Jhuma; Dokholyan, Nikolay V

    2015-10-01

    The increased risk of developing Alzheimer's disease (AD) is associated with the APOE gene, which encodes for three variants of Apolipoprotein E, namely E2, E3, E4, differing only by two amino acids at positions 112 and 158. ApoE4 is known to be the strongest risk factor for AD onset, while ApoE3 and ApoE2 are considered to be the AD-neutral and AD-protective isoforms, respectively. It has been hypothesized that the ApoE isoforms may contribute to the development of AD by modifying the homeostasis of ApoE physiological partners and AD-related proteins in an isoform-specific fashion. Here we find that, despite the high sequence similarity among the three ApoE variants, only ApoE4 exhibits a misfolded intermediate state characterized by isoform-specific domain-domain interactions in molecular dynamics simulations. The existence of an ApoE4-specific intermediate state can contribute to the onset of AD by altering multiple cellular pathways involved in ApoE-dependent lipid transport efficiency or in AD-related protein aggregation and clearance. We present what we believe to be the first structural model of an ApoE4 misfolded intermediate state, which may serve to elucidate the molecular mechanism underlying the role of ApoE4 in AD pathogenesis. The knowledge of the structure for the ApoE4 folding intermediate provides a new platform for the rational design of alternative therapeutic strategies to fight AD.

  19. The new site selection process in Germany. Results of the &apos;&apos;Commission Disposal of High Radioactive Waste&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Brammer, Klaus-Juergen; Weber, Stefan [GNS Gesellschaft fuer Nuklear-Service mbH, Essen (Germany)

    2016-10-15

    After the open exploration of the salt dome Gorleben was suspended for political reasons and in favour of a new selection process in Germany the German Bundestag passed the site selection law mid-2013. It provides a three-phase process, which shall lead to the designation of a site with &apos;&apos;best possible safety&apos;&apos; in particular for highly radioactive waste in the year 2031. Early July 2016 the &apos;&apos;Commission Disposal of High Radioactive Waste&apos;&apos; submitted now its final report. Thus it is up to the legislator to legally implement the commission&apos;s recommendations and to clear the path for the start of phase 1 of the selection process.

  20. Design of the fuel element &apos;snow-flake&apos; in uranium oxide, canned with aluminium, for the experimental reactor EL 3 (1960); Etude d&apos;un element combustible en oxyde d&apos;uranium gaine d&apos;aluminium, type &apos;&apos;cristal de neige&apos;&apos; pour la pile EL 3 (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Gauthron, M.; Guibert, B. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    This report sums up the main studies have been carried out on the fuel element &apos;Snowflake&apos; (uranium oxide, canned with aluminium), designed to replace the present element of the experimental reactor EL3 in order to increase the reactivity without modifying the neutron flux/thermal power ratio. (author) [French] Ce rapport resume les principales etudes qui ont ete faites sur l&apos;element combustible &apos;Cristal de Neige&apos; (a oxyde d&apos;uranium, gaine d&apos;aluminium) destine a remnlacer l&apos;element actuel du reacteur experimental EL3, afin d&apos;en augmenter la reactivite sans modifier le rapport flux neutronique-puissance thermique. (auteur)

  1. The human apoE7 and apoE4 transgenic mice models

    Institute of Scientific and Technical Information of China (English)

    SUN; Mingzeng; (

    2001-01-01

    [1]Weisgraber, K. H., Apolipoprotein E: Structure-function relationships, Adv. Pro. Chem., 1994, 45: 249-302.[2]Center, G. F., Paoletti, E. G., Apolipoprotein function in health and disease: Insights from natural mutations, Europ. J. Clin. Invest., 1996, 26: 733-746.[3]Browner, J. D., van Dormal, J. J., Muskiet, A. J., Clinical chemistry of common apolipoproteins, J. Chromat. B, 1996, 678: 623-641.[4]Maeda, H., Nakamura, H., Shozo, K. et al., Identification of human apolipoprotein E variant gene: Apolipoprotein E7 (Glu244, 245 Lys244, 245), J. Biochm., 1989, 105: 51-54.[5]Taylor, J. M., Downstream regulatory elements stimulate expression of the human plipoprotein E gene in the liver and suppress expression in the kidney of transgenic mice, Transassoc. Am. Physicians, 1990, 103: 119-128.[6]Smith, J. D., Plump, A. S., Breslow, J. L. et al., Accumulation of human apolipoprotein E in the plasma of transgenic mice, J. Biol. Chem., 1990, 265(25): 14709-14712.[7]Tazio, S., Lee, Y. L., Ji, Z. S. et al., Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E, J. Clin. Invest., 1993, 92(3): 1497-1503.[8]Arn, M. J., Maagdenberg, M., Hofker, M. N. et al., Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia, The J. Biol. Chem., 1993, 268(14): 10540-10545.[9]Qi, Z. H., Ru, K., Sun, M. Z. et al., The gene expression of pME in mouse NIH/3T3 cells and construction of the h-apoE transgenic mice, Chinese Biochem. J., 1997, 13(1): 24-28.[10]Sambrook, J., Fritsch, E. F., Maniatis, T., Molecular Cloning, A Laboratory Manual, New York: CSH Press, 1989, 81.[11]Hogan, B. L., Manipulation the mouse embryo, A Laboratory Manual, New York: CSH Press, 1989, 89.[12]Wandell, M. R., Rall, S. C., Brennan, S. Jr et al., Apolipoprotein E2-Dunedin (228 Arg-Cys): Anapolipoprotein E2 variant with normal receptor-binding activity, J. Lip. Res., 1990, 31: 534-543.[13

  2. OPEC&apos;s strategies

    Energy Technology Data Exchange (ETDEWEB)

    Wirl, Franz [Vienna Univ. (Austria). Faculty of Business, Economics and Statistics

    2012-09-15

    This paper investigates rationale explanations of OPEC&apos;s strategies. Accounting for market characteristics in particular the sluggishness of demand and supply allows to explain price jumps as rational OPEC strategies from a narrow economic perspective (up and down) as well as from political objectives (at least up) due to the political payoff from standing up against the &apos;West&apos;. Although the temptation to accrue this political payoff was and remains high, the narrow economic profit motive coupled with an imperfect cooperation among OPEC members explains past price volatility and high prices much better than the usual reference to political events. A more specific prediction is that OPEC will switch back to setting prices since the current quantity strategy encourages oil importing countries to appropriate rents in particular in connection with the need to mitigate global warming. (orig.)

  3. A model for economical integration of &apos;&apos;Green power&apos;&apos; into the grid. VDE-Study &apos;Smart Distribution 2020&apos;; Ein Modell fuer die wirtschaftliche Integration von Oekostrom ins Netz. VDE-Studie &apos;Smart Distribution 2020&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Jopp, Klaus

    2008-07-01

    The model of this study motivates &apos;'green'&apos; power generation due to the demand in the frame of virtual power plants, therefore the connection of green power generators regulated consumers and power storage. Conditions for virtual power plants is an &apos;&apos;Apollo program&apos;&apos; for an armament to the grids by information- and communication technologies as investigation on advanced storage engineering. With special efforts Germany should be able to play a leading role on intelligent grid management, which may be developed as an import hit. (GL)

  4. Carcinoma hepatocelular: parte 2. Tratamento Hepatocelular carcinoma: part 2. Therapy

    Directory of Open Access Journals (Sweden)

    Vinício Paride CONTE

    2000-04-01

    Full Text Available São revisadas as formas de tratamento, particularmente as ressecções cirúrgicas, a quimioembolização arterial e as injeções percutâneas de etanol e de ácido acético. Alguns aspectos relativos à dieta, com particular atenção à aflatoxina B1 e aos retinóides, são abordados quanto ao seu desempenho na etiopatogenia e no tratamento da afecção mais comumente encontrada nos países em desenvolvimento. Em relação ao tratamento, fazem-se considerações também referentes ao uso de octreotide, nitrosaminas e outras drogas. A coagulação intersticial a laser e as drogas de ação antivascular também mereceram abordagem sucinta. O problema do carcinoma hepatocelular precoce e a sua destruição é sinalizado de modo sumário. A quimioprevenção com o uso do interferon alfa recombinante considerado e o transplante de fígado encerram a revisão, antes dos comentários finais.Recent improvements on the therapeutical management of hepatocellular carcinoma are revised with special attention to evaluate the role of surgery for the disease. Considering that definitive surgical intervention is not feasible in most cases because of extreme tumor extension, multiplicity of tumor foci, and associated advanced liver cirrhosis at the time of diagnosis, others forms of treatment are listed, such as transcatheterarterial chemoembolization, percutaneous ethanol and acetic acid injections, and chemotherapy only to a small portion of patients with no indication for standard treatments The emerging role of retinoic acid metabolism blocking agents, was examined and may offer a significant new potential treatment for cancer, inclusive the possibility of combining other anticancer drugs with exogenous retinoids or modulation of endogenous retinoids as a real opportunity to advance our ability to treat or prevent human cancer effectively. Octreotide, nitrosamine and other drugs are analyzed and is concluded that improves survival and is a valuable

  5. Endocardite infecciosa: 12 anos de tratamento cirúrgico

    Directory of Open Access Journals (Sweden)

    ARNONI Antoninho Sanfins

    2000-01-01

    Full Text Available INTRODUÇÃO: A endocardite é uma doença de tratamento difícil e que freqüentemente necessita da participação cirúrgica. CASUÍSTICA E MÉTODOS: Entre janeiro de 1987 e janeiro de 1999, 159 pacientes foram operados em nosso Serviço, sendo 64,7% do sexo masculino. Este grupo apresentou idade média de 39,2 anos (2 a 78 anos, com peso médio de 57,1 kg. O acometimento valvar aórtico foi o mais freqüente (66 pacientes, sendo na valva nativa em 47 casos e em próteses em 19 (8 metálicas e 11 biológicas: a lesão mitral verificou-se em 53 pacientes, sendo mais comum em portadores de prótese (28 biológicas e 2 metálicas. O comprometimento das duas valvas esteve presente em 28 casos. Os demais pacientes eram portadores de defeitos congênitos ou de marcapasso definitivo. A operação foi indicada por refratariedade ao tratamento clínico, insuficiência cardíaca, quadro infeccioso levando a disfunção valvar ou de prótese, vazamento periprotético, ou ainda por arritmia. RESULTADOS: O estudo microbiológico evidenciou maior prevalência de infecção por Streptococcus viridans e Staphilococcus aureus. A operação realizada nos portadores de endocardite infecciosa em valva nativa propiciou a conservação da valva em 3 pacientes do grupo mitral e em 1 do grupo aórtico; nos demais pacientes empregaram-se próteses (a maioria metálica em aórticos e biológica em mitrais. As reoperações foram freqüentes, tendo pacientes com até quarta operação. A lesão congênita responsável pela maioria dos casos foi a comunicação interventricular (3 casos e 4 pacientes apresentavam a endocardite em eletrodo de marcapasso. A mortalidade global foi de 16,3%, com maior incidência em portadores de prótese mitral e aórtica submetidos a reoperação. A presença de abscesso como complicação da endocardite infecciosa verificou-se em 18,2% dos pacientes, utilizando-se pericárdio bovino na reconstrução da maioria, com mortalidade de 17

  6. Derivados canabinóides e o tratamento farmacológico da dor

    OpenAIRE

    2016-01-01

    RESUMO JUSTIFICATIVA E OBJETIVOS: As propriedades medicinais da Cannabis sativa têm sido relatadas por muitos séculos para o tratamento de diversos distúrbios e, mais recentemente, para o tratamento da dor. O objetivo deste estudo foi revisar os principais avanços na farmacologia do sistema endocanabinóide e no potencial uso terapêutico de alguns compostos canabinóides no tratamento de diversas formas de dor. CONTEÚDO: Foi realizada uma busca nos bancos de dados Pubmed, Scielo e Lilacs, ide...

  7. Test on an external wall. Ecological model project and PV test stand: The Vienna &apos;'Energybase'&apos;; Fassade als Pruefstand. Oekologisches Modellprojekt und gleichzeitig Photovoltaikteststand: Das &apos;Energybase&apos; in Wien

    Energy Technology Data Exchange (ETDEWEB)

    Siemer, J.

    2008-08-15

    Solar cooling, room air humidification with plants, and daylighting even of the underground garage: The Vienna &apos;'Energybase'&apos; office building is a demonstration project in many ways. Its PV system on the south-facing external wall profits from the architecture with its single-minded orientation along renewable energy use. The building will be used by the Arsenal Research research institute for module and current inverter testing. (orig.)

  8. Cash management system &apos;CEREUS-SM&apos;; Supermarket muke kinsen shoriki &apos;CEREUS-SM&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Niizuma, N.; Fukushima, Y.; Kinoshita, S. [Fuji Electric Co. Ltd., Tokyo (Japan)

    2000-03-10

    The adjustment system with change in coin has reduced cashier work in supermarkets, and has spread as the standard peripheral equipment of the point of sales (POS) system. Recently, there have been customer needs for a type with change in bill and coin. Fuji Electric has developed cash management system &apos;CEREUS-SM&apos; which is as small as the current system only with change in coin and can be handled by anyone, including a part-timer or a student worker. (author)

  9. 2001-2003 &apos;&apos;public utility&apos;&apos; contract between the French government and Gaz de France; Contrat de &apos;&apos;service public&apos;&apos; 2001-2003 entre l&apos;etat et Gaz de France

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    The &apos;&apos;public utility&apos;&apos; contract aims at specifying the actions of Gaz de France (GdF), the French gas utility, in terms of national development and public utility presence at the local scale. It extends and completes the &apos;contract of group&apos; established between the government and GdF in the domain of quality of the services offered to clients, development of gas infrastructures and extension of gas supplies, and sustainable development. (J.S.)

  10. The role of the &apos;&apos;Neutral Service Provider&apos;&apos; in the liberalised gas market; Die Rolle des &apos;&apos;Neutral Service Provider&apos;&apos; im liberalisierten Erdgasmarkt

    Energy Technology Data Exchange (ETDEWEB)

    Peper, F.; Greverath, I. [Viavera GmbH Dortmund (Germany)

    2002-07-01

    The ongoing liberalisation of European gas markets forces network operators as well as retail companies to implement new processes. This article focuses on the challenges for network operators. In this context the potential for &apos;Neutral Service Providers (NSP)&apos; is discussed. Based on sample TPA processes the interaction between the NSP and the network operator is explored. The authors conclude that for many market participants the outsourcing of TPA processes to a specialized service provider has the potential to deliver significant benefits. (orig.) [German] Die fortschreitende Liberalisierung der europaeischen Erdgasmaerkte stellt die Netz- sowie die Vertriebsgesellschaften vor staendig wachsende Anforderungen. Dabei wird in diesem Artikel der Schwerpunkt auf die Komplexitaet der Aufgaben insbesondere fuer Netzbetreiber gelegt. In diesem Zusammenhang werden die hieraus resultierenden Marktchancen fuer neue Dienstleistungsunternehmen, die sogenannten &apos;Neutral Service Provider&apos; (NSP) eroertert. Anhand eines Prozessbeispiels wird die Interaktion zwischen NSP und den von ihm betreuten Netzbetreibern diskutiert. Die Autoren kommen zu dem Schluss, dass fuer viele Marktteilnehmer die Auslagerung bestimmter Unternehmensaktivitaeten im Zusammenhang mit der Bewaeltigung des Netzzugangs Dritter an einen spezialisierten Dienstleister mit erheblichen Vorteilen verbunden ist. (orig.)

  11. &apos;Massless&apos; vector field in de Sitter Universe

    Energy Technology Data Exchange (ETDEWEB)

    Garidi, T.; Gazeau, J-P. [APC, CNRS UMR 7164, Universite Paris 7, Denis Diderot, Boite 7020, F-75251 Paris Cedex 05 (France); Rouhani, S. [Plasma Physics Research Center, Islamic Azad University, P.O.BOX 14835-157, Tehran (Iran, Islamic Republic of); Takook, M.V. [Department of Physics, Razi University, Kermanshah (Iran, Islamic Republic of)

    2006-04-15

    In the present work the massless vector field in the de Sitter (dS) space has been quantized. &apos;Massless&apos; is used here by reference to conformal invariance and propagation on the dS light-cone whereas &apos;massive&apos; refers to those dS fields which contract at zero curvature unambiguously to massive fields in Minkowski space. Due to the gauge invariance of the massless vector field, its covariant quantization requires an indecomposable representation of the de Sitter group and an indefinite metric quantization. We will work with a specific gauge fixing which leads to the simplest one among all possible related Gupta-Bleuler structures. The field operator will be defined with the help of coordinate independent de Sitter waves (the modes) which are simple to manipulate and most adapted to group theoretical matters. The physical states characterized by the divergence-lessness condition will for instance be easy to identify. The whole construction is based on analyticity requirements in the complexified pseudo-Riemannian manifold for the modes and the two-point function. (authors)

  12. ApoE mimetic peptide decreases Aβ production in vitro and in vivo

    Directory of Open Access Journals (Sweden)

    Pak Daniel TS

    2010-04-01

    Full Text Available Abstract Background Apolipoprotein E (apoE is postulated to affect brain Aβ levels through multiple mechanisms--by altering amyloid precursor protein (APP processing, Aβ degradation, and Aβ clearance. We previously showed that an apoE-derived peptide containing a double repeat of the receptor-binding region was similarly effective in increasing APP processing in vivo. Here, we further examined whether peptides containing tandem repeats of the apoE receptor-binding region (amino acids 141-149 affected APP trafficking, APP processing, and Aβ production. Results We found that peptides containing a double or triple tandem repeat of the apoE receptor-binding region, LRKLRKRLL, increased cell surface APP and decreased Aβ levels in PS1-overexpressing PS70 cells and in primary neurons. This effect was potentiated by a sequential increase in the number of apoE receptor-binding domain repeats (trimer > dimer > monomer. We previously showed that the apoE dimer increased APP CTF in vivo; to determine whether the dimer also affected secreted APP or Aβ levels, we performed a single hippocampal injection of the apoE dimer in wild-type mice and analyzed its effect on APP processing. We found increased sAPPα and decreased Aβ levels at 24 hrs after treatment, suggesting that the apoE dimer may increase α-secretase cleavage. Conclusions These data suggest that small peptides consisting of tandem repeats of the apoE receptor-binding region are sufficient to alter APP trafficking and processing. The potency of these peptides increased with increasing repeats of the receptor binding domain of apoE. In addition, in vivo administration of the apoE peptide (dimer increased sAPPα and decreased Aβ levels in wild-type mice. Overall, these findings contribute to our understanding of the effects of apoE on APP processing and Aβ production both in vitro and in vivo.

  13. Vertigo Imaging; Clinical Radiology&apos;

    Directory of Open Access Journals (Sweden)

    Jalal Jalal Shokouhi

    2009-01-01

    Full Text Available   "n- Dizziness that patients complain from are rotational vertigo, sense of instability, ataxia of gait, disturbance of vision, loss of contact with surroundings, nausea, loss of memory, loss of confidence, epileptic convulsion and dizziness that is considered by medical staff are: "n1- Vertigo as a sense of feeling the environment moving when it does not persist in all positions, aggravated by head movement. "n2- Disequilibrium as a feeling of unsteadiness or insecurity without rotation, standing and walking are difficult. "n3- Light headedness as swimming, floating, giddy or swaying sensation in the head or in the room. "nTaking the history from a vertigo patient:* "n            What the patient means by vertigo?- "n- Time of onset "n-Temporal pattern "n-Associated signs and symptoms &apos;&apos; tinnitus, hearing loss, headache, double vision, numbness and difficulty in swallowing &apos;&apos;. "n- Precipitating, aggravating and relieving factors. "n- If episodic: sequence of events, activity at onset, aura, severity and amnesia. "n*Examination of the vertigo patient checking: "nSpontaneous nystagmus, positional nystagmus, optokinetic nystagmus, posture and balance control like romberg&apos;s test, blind walking, untenberger and barany&apos;s test, stimulation of labyrinth, caloric test &apos;&apos; cold, warm water &apos;&apos; and the rotational test. "nEtiology : "n*Spontaneous nystagmus: "nPosture and balance control is positive with nausea , vomiting , sweating and anxiety : harmonic vestibular sy with loss of hearing , tinnitus , vestibular neuronitis , meniere disease and with otologic origin and dysharmmonic vestibular sy , with numbness , double vision , dysarthria in brain stem infarct and with a neurological origin. "nNonspontaneous nystagmus :Posture and balance negative with nausea, vomiting in GI disorders and internal medicine , sweating and trachycardia by chest pain in angina , M.I &apos;&apos; cardiology &apos;&apos

  14. Effects of nocturnal aircraft noise on sleep: results from the &apos;&apos;quiet air traffic&apos;&apos; project; Wirkungen des Nachtfluglaerms auf den Schlaf: Ergebnisse aus dem Projekt &apos;&apos;Leiser Flugverkehr&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Samel, A.; Basner, M.; Maass, H.; Mueller, U.; Quehl, J.; Wenzel, J. [Deutsches Zentrum fuer Luft- und Raumfahrt (DLR) in der Helmholtz-Gemeinschaft (HGF), Inst. fuer Luft- und Raumfahrtmedizin, Koeln (Germany)

    2005-07-01

    In 192 sleep-healthy subjects (18 to 65 y) effects of nocturnal aircraft noise on sleep, stress, performance and subjective factors were investigated in 2240 nights under laboratory and field conditions. In the sleep lab, 112 volunteers were subjected to aircraft noise events by varying numbers and noise levels during 9 nights within a period of 13 nights. 16 further subjects served as control group (i.e. without any noise). 64 subjects were studied in the vicinity of Cologne-Bonn airport during 9 nights. Polysomnographical and acoustical recordings, determination of excretion rates of stress hormones from night urines, performance tests and questionnaires were conducted during all days for the assessment of nocturnal aircraft noise effects. By simultaneous recording of electrophysiological and acoustical data the probability of noise induced awakenings was estimated. Performance and most of psychological parameters did not show significant dose-effect relationships, whereas annoyance did. Epinephrine and norepinephrine did not change under aircraft noise, cortisol did change only in the lab. In the lab, a comparison between all noisy nights and noise-free baseline nights exhibited a non-significant 2-min. reduction of sleep and a 4-min. decrease of slow-wave sleep. In the field, awakenings caused by aircraft noise were detected above a threshold of 33 dB(A) &apos;&apos;at the sleeper&apos;s ear&apos;&apos;. All effects were much less pronounced in the field than in the lab. For the first time, precise dose-effect curves between maximum aircraft noise event levels and electrophysiologically detectable awakenings, and a threshold were empirically established. The results of these studies broadens the knowledge on aircraft noise induced sleep disturbances and immediate consequences for the next day. (orig.)

  15. Data acquisition and control using National Instruments&apos; LabVIEW&apos;&apos; software

    Energy Technology Data Exchange (ETDEWEB)

    Kirkman, I.W.; Buksh, P.A. (SERC Daresbury Laboratory, Warrington, Cheshire WA4 4AD (United Kingdom))

    1992-01-01

    Using conventional programming techniques for the production of data acquisition and control software can be a time-consuming procedure, and the code subsequently produced can often be inflexible and rather difficult to modify in the light of changing experimental requirements. A new generation of commercial software products have recently appeared which it is claimed can significantly reduce development times and give rise to more flexible code and improved user interfaces. An example of such a product is National Instruments&apos; LabVIEW,&apos;&apos; which presents a novel graphical approach based on Apple Macintosh computer platforms. Extensive use of LabVIEW has been made by the Soft X-ray Group at Daresbury Laboratory over the past two years, and its performance is reported on here. Several examples of experimental arrangements for which it has been used are described, and an evaluation of the product is made.

  16. PROCTOSSIGMOIDECTOMIA VIA PERINEAL NO TRATAMENTO DO PROLAPSO RETAL

    Directory of Open Access Journals (Sweden)

    Bueno R. N.

    2001-01-01

    Full Text Available A técnica cirúrgica mais utilizada no tratamento do prolapso retal é a sacropromontofixação do reto por via abdominal, porém nos últimos anos a proctossigmoidectomia via perineal tem sido retomada como alternativa para pacientes idosos com comorbidades. Revisamos 14 casos operados pela proctossigmoidectomia via perineal (cirurgia de Altemeier, sendo 13 mulheres e 1 homem. Destes pacientes havia 50% de obstipados, 14,2% tinham diarréia crônica e 64,2% eram previamente incontinentes. Idade média de 72,2 anos, 64,2 % com anastomose manual e 35,8% mecânica, além de 42,9% com reparo anal posterior no mesmo tempo operatório. O tempo médio de internação foi de 3,8 dias, não houve complicações imediatas ou precoces e apenas ocorreu recidiva em 01 paciente, 7,1%. Pelos bons resultados, baixa morbi-mortalidade e recidiva aceitável e de acordo com a literatura nos encorajamos à utilização desta técnica para correção do prolapso retal .

  17. Fenitoína – fronteiras do tratamento

    Directory of Open Access Journals (Sweden)

    Joaquina Antunes

    2016-02-01

    Full Text Available Introdução: As crises convulsivas são manifestações clínicas frequentes no período neonatal. Continua pouco claro qual a melhor abordagem terapêutica, não existindo ainda consenso entre os diversos protocolos. A terapêutica antiepilética usada tradicionalmente é, muitas vezes, pouco eficaz e pode originar efeitos secundários importantes. Caso Clínico: Apresenta-se o caso clínico de um recém-nascido que iniciou convulsões no primeiro dia de vida. Por persistência das crises após terapêutica com fenobarbital, foi iniciada fenitoína, tendo desenvolvido um quadro de encefalopatia devida a intoxicação por este fármaco, apesar do seu uso em doses habituais. Dado que a investigação complementar foi normal, concluiu-se que esta se deveu provavelmente a susceptibilidade individual. Conclusão: Atendendo aos potenciais efeitos secundários da fenitoína, mais frequentes e graves em recém-nacidos, este fármaco tende a ser menos usado como segunda linha no tratamento das convulsões neste grupo etário, considerando-se atualmente as benzodiazepinas e a lidocaína alternativas mais eficazes e seguras.

  18. Aerosol activity distribution on aerodynamic diameter inside the object &apos;'Shelter'&apos;: physical and dosimetric aspects

    Energy Technology Data Exchange (ETDEWEB)

    Bondarenko, O.A.; Aryasov, P.B.; Medvedev, S.Yu.; Nesmiyan, I.M. [Radiation Protection Inst., Kiev (Ukraine); Zhidkov, A.V. [ISTC ' ' Shelter' ' , Chernobyl, Kiev (Ukraine)

    2001-07-01

    Experimental results of the aerosol size distribution inside the Object &apos;'Shelter'&apos; are evaluated in the work. The results show a consistent and significant contribution of sub-micron fraction to the total aerosol activity. Different methods of interpretation of impactor data series are evaluated in terms of adequate assessment of the separate sub-micron aerosol fraction. The contribution of the sub-micron component to the total aerosol activity was found to be about 35%. Results of this research were also compared to those of other authors conducted with by using identical impactor equipment, e.g. results of aerosol sampling at a Czech NPP Dukovany. It is demonstrated in the work that observation of such a significant contribution of the sub-micron fraction for the Shelter aerosol can be hardly explained by systematic failure of the sampling equipment. Also physical mechanisms and corresponding observations of sub-micron aerosol generation inside the Shelter as well as subsequent dosimetric aspects are discussed. (orig.)

  19. &apos;'Green'&apos; Biopolymers for Improved Decontamination of Metals from Surfaces: Sorptive Characterization and Coating Properties

    Energy Technology Data Exchange (ETDEWEB)

    Davison, Brian H.; Kuritz, Tanya

    2000-06-01

    The proposed research aims to develop a fundamental understanding of important biological and physical chemical parameters for effective decontamination of metal surfaces using environmentally benign aqueous-based biopolymer solutions. Understanding how heavy metal-chelating biopolymers coat and interact with contaminated surfaces will benefit the development of novel, safe, easy-to-apply decontamination methodologies for removal of radionuclides and heavy metals. The benefits of these methodologies will include the following: (1) decreased exposure hazards for workers; (2) decreased secondary waste generation; (3) increased efficiency of decontamination; (4) positive public appeal and development of novel, nature-friendly business opportunities; and (5) lower cost of cleanup to the government. We propose to use aqueous biopolymer solutions to coat a contaminated metal surface (i.e., steel), solubilize the heavy metals (e.g., uranium) from the surface, and bind the heavy metals into the biopolymer. The biopolymer coating (containing the immobilized hazardous metal contaminants) will then be removed as a viscous film, as a dry powder, or by washing. This &apos;&apos;apply, wait, and remove&apos;&apos; procedure will reduce the amount of worker time spent in decontamination activities.

  20. &apos;'Green'&apos; Biopolymers for Improved Decontamination of Metals from Surfaces: Sorptive Characterization and Coating Properties

    Energy Technology Data Exchange (ETDEWEB)

    Davison, Brian H.; Kurtiz,Tanya

    1999-06-01

    The proposed research aims to develop a fundamental understanding of important biological and physical chemical parameters for effective decontamination of metal surfaces using environmentally benign aqueous-based biopolymer solutions. Understanding how heavy metal-chelating biopolymers coat and interact with contaminated surfaces will benefit the development of novel, safe, easy-to-apply decontamination methodologies for removal of radionuclides and heavy metals. The benefits of these methodologies will include the following: (1) decreased exposure hazards for workers; (2) decreased secondary waste generation; (3) increased efficiency of decontamination; (4) positive public appeal and development of novel, nature-friendly business opportunities; and (5) lower cost of cleanup to the government. We propose to use aqueous biopolymer solutions to coat a contaminated metal surface (i.e., steel), solubilize the heavy metals (e.g., uranium) from the surface, and bind the heavy metals into the biopolymer. The biopolymer coating (containing the immobilized hazardous metal contaminants) will then be removed as a viscous film, as a dry powder, or by washing. This &apos;&apos;apply, wait, and remove&apos;&apos; procedure will reduce the amount of worker time spent in decontamination activities.

  1. &apos;'Green'&apos; Biopolymers for Improved Decontamination of Metals from Surfaces: Sorptive Characterization and Coating Properties

    Energy Technology Data Exchange (ETDEWEB)

    Davison, Brian H.

    2002-04-30

    The proposed research aimed to develop a fundamental understanding of important biological and physical chemical parameters for effective decontamination of metal surfaces using environmentally benign aqueous-based biopolymer solutions. Understanding how heavy metal-chelating biopolymers coat and interact with contaminated surfaces will benefit the development of novel, safe, easy-to-apply decontamination methodologies for removal of radionuclides and heavy metals. The benefits of these methodologies include the following: decreased exposure hazards for workers; decreased secondary waste generation; increased efficiency of decontamination; positive public appeal and development of novel, nature-friendly business opportunities; and lower cost of cleanup to the government. We proposed to use aqueous biopolymer solutions to coat a contaminated metal surface (i.e., steel), solubilize the heavy metals (e.g., uranium) from the surface, and bind the heavy metals into the biopolymer. The biopolymer coating (containing the immobilized hazardous metal contaminants) was to be removed as a viscous film, as a dry powder, or by washing. This &apos;&apos;apply, wait, and remove&apos;&apos; procedure will reduce the amount of worker time spent in decontamination activities.

  2. Imaging of bridging vein thrombosis in infants with abusive head trauma: the &apos;&apos;Tadpole Sign&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Hahnemann, Maria L.; Kinner, Sonja; Schweiger, Bernd [University Hospital Essen, Institute of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); Bajanowski, Thomas [University Hospital Essen, Institute of Legal Medicine, Essen (Germany); Karger, Bernd; Pfeiffer, Heidi; Wittschieber, Daniel [University Hospital Muenster, Institute of Legal Medicine, Muenster (Germany)

    2014-10-03

    Abusive head trauma (AHT) in infants is usually diagnosed using a multi-disciplinary approach by investigating the circumstances and identifying morphological indicators, for example, subdural hematomas (SDHs), subdural hygromas (SDHys), retinal haemorrhages and encephalopathy. The present morphological study investigates the incidence, radiological characteristics and non-radiological co-factors of bridging vein thrombosis (BVT) in infants with AHT. From 2002 to 2013, computed tomography (CT) and magnetic resonance imaging (MRI) material of 628 infants aged 0-2 years were analysed retrospectively. If available, medicolegal expert opinions were additionally considered. Cases with SDHs and/or SDHys were identified and systematically evaluated as to the presence and characteristics of BVT. SDHs and/or SDHys were present in 29 of the 81 cases exhibiting morphological abnormalities in the initial CT. Among these, 11 cases (40 %) had BVT (mean age = 5.0 months). BVT could be best depicted in the T1-weighted spin echo and T2*/susceptibility-weighted MRI. In one case, BVT could be depicted indirectly using time-of-flight MR venography. The predominant (73 %) BVT shape was found to be tadpole-like (&apos;&apos;Tadpole Sign&apos;&apos;). In the absence of appropriate accidental trauma, BVT appears to be a strong indicator of AHT. Therefore, the BVT/Tadpole Sign represents compelling cause to search for other signs of AHT. (orig.)

  3. Final Report on Project 01-ERD-017 &apos;&apos;Smart Nanostructures From Computer Simulations&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Grossman, J C; Williamson, A J

    2004-02-13

    This project had two main objectives. The first major goal was to develop new, powerful computational simulation capabilities. It was important that these tools have the combination of the accuracy needed to describe the quantum mechanical nature of nanoscale systems and the efficiency required to be applied to realistic, experimentally derived materials. The second major goal was to apply these computational methods to calculate and predict the properties of quantum dots--initially composed of silicon, but then of other elements--which could be used to build novel nanotechnology devices. The driving factor of our purpose has been that, through the development and successful application of these tools, we would generate a new capability at LLNL that could be used to make nanostructured materials &apos;'smarter'&apos;, e.g., by selectively predicting how to engineering specific, desired properties. To carry out the necessary work to successfully complete this project and deliver on our goals, we established a two-pronged effort from the beginning: (1) to work on developing new, more efficient algorithms and quantum simulation tools, and (2) to solve problems and make predictions regarding properties of quantum dots which were being studied experimentally here at Livermore.

  4. Resonant light power buildup in ALPS, a &apos;&apos;light shining through a wall&apos;&apos;-experiment

    Energy Technology Data Exchange (ETDEWEB)

    Meier, Tobias; Danzmann, Karsten; Willke, Benno [Max-Planck-Institut fuer Gravitationsphysik, Albert Einstein Institut (Germany); Institut fuer Gravitationsphysik, Leibniz Universitaet Hannover, Callinstrasse 38, D-30167 Hannover (Germany); Ehret, Klaus; Ghazaryan, Samvel; Knabbe, Axel; Lindner, Axel; List, Jenny; Meyer, Niels; Notz, Dieter; Redondo, Javier; Ringwald, Andreas [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, D-22607 Hamburg (Germany); Frede, Maik; Hildebrandt, Matthias [Laserzentrum Hannover e.V., Hollerithallee 8, D-30419 Hannover (Germany); Wiedemann, Guenter [Hamburger Sternwarte, Gojenbergsweg 112, D-21029 Hamburg (Germany)

    2009-07-01

    We report on the first successfull application of a new experimental technique to search for weakly interacting sub-eV particles (WISPs) coupling to photons. As part of the ALPS experiment located at DESY in Hamburg, this technique uses an optical resonator to enhance the power inside a HERA dipole magnet on the production side of a typical &apos;&apos;light shining through a wall&apos;&apos;-experiment. We use a frequency doubled continuous-wave laser emitting 0.6 W of power at 532 nm that is stabilized to a linear optical resonator with 8 m length. On resonance we achieve a circulating power of 34 W within the magnet. With this we obtained sensitivities corresponding to a coupling strength of g{approx}5.10{sup -7} GeV{sup -1} for interactions of axion-like particles and photons. The experimental setup and possible improvements are described and compared with common experimental designs with pulsed lasers.

  5. On the universality of the &apos;'smile'&apos;-gap in the density of states of a chaotic Josephson junction

    Energy Technology Data Exchange (ETDEWEB)

    Reutlinger, Johannes; Belzig, Wolfgang [University of Konstanz, Department of Physics (Germany); Nazarov, Yuli [Kavli Institute of Nanoscience Delft, Delft University of Technology, Delft (Netherlands); Glazman, Leonid [Department of Physics, Yale University, New Haven, CT (United States)

    2015-07-01

    The superconducting proximity effect strongly modifies the local density of states in chaotic Josephson junctions. Recently we found that besides the well-known minigap a secondary gap appears just below the superconducting gap edge Δ in the limit of a large Thouless energy E{sub Th} >or similar Δ. To check the universality of this novel gap phenomenon we study the effect of nonideal contacts and show that the &apos;'smile'&apos;-gap crucially depends on the transmission eigenvalue distribution. In a next step we use the random matrix method to investigate the &apos;'smile'&apos;-gap. This allows us to approach the statistics of Andreev levels, going beyond the quasiclassical Greens function method. It turns out that the hard gap edge softens similar to what is already known from the minigap.

  6. Inorganic profile of some Brazilian medicinal plants obtained from ethanolic extract and &apos;&apos;in natura&apos;&apos; samples

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, M.O.M.; de Sousa, P.T.; Salvador, V.L.R.; Sato, I.M.

    2004-10-03

    The Anadenathera macrocarpa, Schinus molle, Hymenaea courbaril, Cariniana legalis, Solidago microglossa and Stryphnodendron barbatiman, were collected &apos;&apos;in natura&apos;&apos; samples (leaves, flowers, barks and seeds) from different commercial suppliers. The pharmaco-active compounds in ethanolic extracts had been made by the Mato Grosso Federal University (UFMT). The energy-dispersive x-ray fluorescence (ED-XRF) spectrometry was used for the elemental analysis in different parts of the plants and respective ethanolic extracts. The Ca, Cl, Cu, Fe, K, Mg, Mn, Na, Ni, P, Rb, S, Sr and Zn concentrations were determined by the fundamental parameters method. Some specimens showed a similar inorganic profile for &apos;&apos;in natura&apos;&apos; and ethanolic extract samples and some ones showed a distinct inorganic profile. For example, the Anadenathera macrocarpa showed a similar concentration in Mg, P, Cu, Zn and Rb elements in &apos;&apos;in natura&apos;&apos; and ethanolic extract samples; however very different concentration in Na, S, Cl, K , Ca, Mn, Fe and Sr was observed in distinctive samples. The Solidago microglossa showed the K, Ca, Cl, S, Mg, P and Fe elements as major constituents in both samples, suggesting that the extraction process did not affect in a considerable way the &apos;&apos;in natura&apos;&apos; inorganic composition. The elemental composition of the different parts of the plants (leaves, flowers, barks and seeds) has been also determined. For example, the Schinus molle specimen showed P, K, Cl and Ca elements as major constituents in the seeds, Mg, K and Sr in the barks and Mg, S, Cl and Mn in the leaves, demonstrating a differentiated elementary distribution. These inorganic profiles will contribute to evaluate the quality control of the Brazilian herbaceous trade and also will assist to identify which parts of the medicinal plants has greater therapeutic effect.

  7. Attributional Gender Bias: Teachers&apos; Ability and Effort Explanations for Students&apos; Math Performance

    Science.gov (United States)

    Espinoza, Penelope; Arêas da Luz Fontes, Ana B.; Arms-Chavez, Clarissa J.

    2014-01-01

    Research is presented on the attributional gender bias: the tendency to generate different attributions (explanations) for female versus male students&apos; performance in math. Whereas boys&apos; successes in math are attributed to ability, girls&apos; successes are attributed to effort; conversely, boys&apos; failures in math are attributed to a…

  8. &apos;Drooping shoulder&apos; - nontraumatic causes of glenohumeral subluxation

    Energy Technology Data Exchange (ETDEWEB)

    Lev-Toaff, A.S.; Karasick, D.; Rao, V.M.

    1984-06-01

    Nontraumatic glenohumeral subluxation can occur in patients with hemiplegia or brachial plexus involvement by tumor. Two cases of inferior subluxation of the humeral head are presented and nontraumatic etiologies of the &apos;&apos;drooping shoulder&apos;&apos; are discussed.

  9. Spanish participation in the R and D program in radiation protection within the field&apos;&apos;Safety in Nuclear Fission&apos;&apos; of ECC (1992-1993). Participacion espaola en el programa de I+D en proteccion radiologica dentro del area de &apos;&apos; Seguridad de la fision nuclear&apos;&apos; de la CEE (1992-93)

    Energy Technology Data Exchange (ETDEWEB)

    1993-01-01

    Twenty two Spanish research teams from Universities, Hospitals, Foundations, as well as CIEMAT, have received contributions from the EC of 188 million pesetas. This funding corresponds to the Program: &apos;&apos;Research in radiation protection&apos;&apos; for the period 1992-1993. The total budget of the program is 3400 million pesetas.

  10. Resource consumption of Germany - indicators and definitions. Development of a glossary on the concept of &apos;'resources'&apos; and calculation of missing characteristic data of resources consumption for further political analysis; Ressourcenverbrauch von Deutschland - aktuelle Kennzahlen und Begriffsbestimmungen. Erstellung eines Glossars zum &apos;'Ressourcenbegriff'&apos; und Berechnung von fehlenden Kennzahlen des Ressourcenverbrauchs fuer die weitere politische Analyse

    Energy Technology Data Exchange (ETDEWEB)

    Schuetz, Helmut; Bringezu, Stefan [Wuppertal Institut fuer Klima, Umwelt, Energie GmbH, Wuppertal (Germany). Forschungsgruppe 3: Stoffstroeme und Ressourcenmanagement

    2008-02-15

    The goals of the reported study are: - to prepare a glossary on the term &apos;'Resources'&apos; in order to support communication based on a harmonised resource term and associated terms and - to provide key data on resource use in Germany in time series since 1991 up to the most recent year for which data were available (2004 in general), and to attribute results to the resource terms. Results achieved are presented and discussed below by the following sections: Provision of a glossary on the term &apos;'resource'&apos;, use of the term &apos;'resource'&apos; at different levels, and provision of data and derived indicators for resource consumption in time series. First, a list of the relevant publications in the topic field &apos;'resources'&apos; was provided and co-ordinated with the client. This publication list is given in the annex to this report. On basis of national and international sources a glossary was provided which clearly describes and comments the resource term, its sub-terms and associated terms. This glossary is in the annex to this report. (orig.)

  11. Childrens&apos; Conceptions of Nature

    Science.gov (United States)

    Payne, Phillip

    2014-01-01

    This paper describes a study of sixth grade children&apos;s conceptions of nature and the environment. In so doing, it asks that environmental educators pay more attention to children&apos;s preconceived notions of environment and nature. Should this occur the theory-practice gap in environmental education may be diminished. Learners&apos; concept…

  12. The Novel SCN&apos;&apos;- Ion-selective Electrode Based on the 1-Benzyl-3-(4-nitrophenyl) thio-urea Ionophore

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyung Mi; Kang, Dong Hyeon; Choe, Ju Eun; You, Jung Min; Go, Min Jeong; Lee, Jung Seong; Jeon, Seung Won [Chungnam National University, Daejeon (Korea, Republic of)

    2014-09-15

    A potentiometric sensor based on the 1-benzyl-3-(4-nitrophenyl) thio-urea was synthesized and tested as an ionophore in PVC based membrane sensor towards SCN - ions. This membrane exhibits a linear stable response over a wide concentration range (1.0 × 10&apos;&apos;-5 to 1.0 × 10&apos;&apos;-2 M) with a slope of -59.2 mV/dec., a detection limit of log[SCN&apos;&apos;- ] = -5.05, and a selectivity coefficient for thiocyanate against perchlorate anion of logK{sub s}cn&apos;&apos;pot = -0.133. The selectivity series of the membrane is as follows: SCN&apos;&apos;- > ClO{sub 4}&apos;&apos;- > I&apos;&apos;- >NO{sub 3}&apos;&apos;- >HSO{sub 3}&apos;&apos;- > Cl&apos;&apos;-HSO{sub &apos;}'-'&apos;4 > F&apos;&apos;- > CH{sub 3}COO&apos;&apos;- > HCO&apos;'-'&apos;3 > Br&apos;&apos;- > H{sub 2}PO{sub 4}&apos;&apos;- > SO{sub 3}&apos;'-'&apos;2 > SO{sub 4}&apos;'-'&apos;2 > CO{sub 3}&apos;'-'&apos;2. The proposed electrode showed good selectivity and a good response for the SCN&apos;&apos;- ion over a wide variety of other anions in pH 6.0 buffer solutions and has a fast response time of about < 5s.. The influences of the membrane by pH, ionophore, and plasticizer were studied.

  13. Introducing Human APOE into Aβ Transgenic Mouse Models

    Directory of Open Access Journals (Sweden)

    Leon M. Tai

    2011-01-01

    Full Text Available Apolipoprotein E (apoE and apoE/amyloid-β (Aβ transgenic (Tg mouse models are critical to understanding apoE-isoform effects on Alzheimer's disease risk. Compared to wild type, apoE−/− mice exhibit neuronal deficits, similar to apoE4-Tg compared to apoE3-Tg mice, providing a model for Aβ-independent apoE effects on neurodegeneration. To determine the effects of apoE on Aβ-induced neuropathology, apoE−/− mice were crossed with Aβ-Tg mice, resulting in a significant delay in plaque deposition. Surprisingly, crossing human-apoE-Tg mice with apoE−/−/Aβ-Tg mice further delayed plaque deposition, which eventually developed in apoE4/Aβ-Tg mice prior to apoE3/Aβ-Tg. One approach to address hAPOE-induced temporal delay in Aβ pathology is an additional insult, like head injury. Another is crossing human-apoE-Tg mice with Aβ-Tg mice that have rapid-onset Aβ pathology. For example, because 5xFAD mice develop plaques by 2 months, the prediction is that human-apoE/5xFAD-Tg mice develop plaques around 6 months and 12 months before other human-apoE/Aβ-Tg mice. Thus, tractable models for human-apoE/Aβ-Tg mice continue to evolve.

  14. Conference: &apos;Heating with Wood&apos;. An alternative to fossil fuels? Status and perspectives. Documentation; Tagung: &apos;Heizen mit Holz&apos;. Eine Alternative zur fossilen Energie? Stand der Technik und neue Perspektiven. Dokumentation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    Main topics of the meeting &apos;&apos;Heating with wood&apos;&apos; were: resource assessment, economical aspects, logistics, cogeneration, district heating, plantation and harvesting of fast growing trees, new heating systems.(uke)

  15. Reply to &apos;Noether&apos;s theorem once again&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Marinho, Rubens M Jr [Departamento de Fisica, Instituto Tecnologico de Aeronautica (Brazil)], E-mail: marinho@ita.br

    2009-09-15

    This reply answers the issues raised in the comment on my paper (Marinho Jr 2007 Eur. J. Phys. 28 37-43), obtains the Laplace-Runge-Lenz vector (Goldstein 2002 Classical Mechanics 3rd edn (Reading, MA: Addison-Wesley)) using Noether&apos;s theorem and includes a Maple program used to derive the results. (letters and comments)

  16. Chronic radiation effects on dental hard tissue (&apos;&apos;radiation carries&apos;&apos;). Classification and therapeutic strategies; Chronische Strahlenfolgen an den Zahnhartgeweben (&apos;'Strahlenkaries'&apos;). Klassifikation und Behandlungsansaetze

    Energy Technology Data Exchange (ETDEWEB)

    Groetz, K.A.; Brahm, R.; Al-Nawas, B.; Wagner, W. [Universitaetsklinik und Poliklinik fuer Mund-, Kiefer- und Gesichtschirurgie, Mainz (Germany); Riesenbeck, D.; Willich, N. [Universitaetsklinik und Poliklinik fuer Strahlentherapie -Radioonkologie, Muenster (Germany); Seegenschmiedt, M.H. [Alfried-Krupp-Krankenhaus Essen (Germany). Klinik und Poliklinik fuer Radioonkologie, Strahlentherapie und Nuklearmedizin; Doerr, W. [Technische Univ. Dresden (Germany). Klinik und Poliklinik fuer Strahlentherapie und Radioonkologie; Kutzner, J.; Thelen, M. [Universitaetsklinik und Poliklinik fuer Radiologie/Strahlentherapie, Mainz (Germany)

    2001-02-01

    Objectives: Since the first description of rapid destruction of dental hard tissues following head and neck radiotherapy 80 years ago, &apos;radiation caries&apos; is an established clinical finding. The internationally accepted clinical evaluation score RTOG/EORTC however is lacking a classification of this frequent radiogenic alteration. Material and Methods: Medical records, data and images of radiation effects on the teeth of more than 1,500 patients, who underwent periradiotherapeutic care, were analyzed. Macroscopic alterations regarding the grade of late lesions of tooth crowns were used for a classification into 4 grades according to the RTOG/EORTC guidelines. Results: No early radiation effects were found by macroscopic inspection. In the first 90 days following radiotherapy 1/3 of the patients complained of reversible hypersensitivity, which may be related to a temporary hyperemia of the pulp. It was possible to classify radiation caries as a late radiation effect on a graded scale as known from RTOG/EORTC for other organ systems. This is a prerequisite for the integration of radiation caries into the international nomenclature of the RTOG/EORTC classification. Conclusions: The documentation of early radiation effects on dental hard tissues seems to be neglectable. On the other hand the documentation of late radiation effects has a high clinical impact. The identification of an initial lesion at the high-risk areas of the neck and incisal part of the tooth can lead to a successful therapy as a major prerequisite for orofacial rehabilitation. An internationally standardized documentation is a basis for the evaluation of the side effects of radiooncotic therapy as well as the effectiveness of protective and supportive procedures. (orig.) [German] Fragestellung: Die rasche Zahnhartgewebszerstoerung nach einer Kopf-Hals-Bestrahlung wurde bereits vor fast 80 Jahren als &apos;Strahlenkaries&apos; beschrieben und ist seither als klinischer Befund in der Routine

  17. Putting &apos;international&apos; back in IPEC.

    Energy Technology Data Exchange (ETDEWEB)

    Veil, J. A.

    2000-10-27

    During the previous six annual sessions of the International Petroleum Environmental Conference (IPEC), little attention has been given to international issues. Although the US is clearly a leader in oil field research and regulatory development information is available on interesting projects throughout the world Many participants in IPEC have little exposure to international oil and gas environmental problems and solutions. Beginning with the 7th IPEC, a stronger effort is being made to include international issues in the confidence. This paper describes some of the author&apos;s experiences in working with international oil and gas environmental issues in North America, Latin America, Europe, and Asia. Among the topics to be discussed are the issues that developing oil and gas-producing nations face and the need for sensitivity to other nation&apos;s cultures and legal systems.

  18. A cool &apos;win-win&apos; for Matra

    Energy Technology Data Exchange (ETDEWEB)

    Wolff, V. [Alstom, Budapest (Hungary)

    2007-07-15

    In 2004 the Matra plant management initiated a 60 M euro investment programme to increase the generating capacity of units 4 and 5 of the lignite fuelled plant and to give it greater flexibility. This has been achieved by adding a 30 MW natural gas-fired topping gas turbine to each of the 230 MW units, for commissioning by 2007. The power uprate meant the capacity of the dry-tower based cooling system was increased by 24 W for each unit. This has now undergone a major upgrade, involving addition of a wet cooling tower to create a &apos;hybrid&apos; system. It is one of the largest such projects ever carried out, and the first involving a dry-tower cooling system of the Heller type. The result is increased competitiveness and efficiency, with a 250,000 t reduction in annual carbon dioxide emissions. 3 figs.

  19. Environmental education project &apos;Mico-Estrela Track&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Vicente, Ana Paula Camargo de; Magalhaes, Milton Pinto Magalhaes; Silva, Simone Rodrigues da; Pinheiro, Roberta Vieira Nunes; Torres, Carlos Alberto Rodrigues; Silveira, Jeanete [PETROBRAS Transporte S.A. (TRANSPETRO), Rio de Janeiro, RJ (Brazil)

    2009-12-19

    Senador Canedo fuel storage terminal is situated in the Cerrado biome and implements the policy of promoting improvements in the preservation of its Green Belt by working out the Environmental Education Project &apos;Mico-Estrela7 Track&apos;, aimed at stimulating the preservation, protection, landscape beauty and defense of scientific sources of the Cerrado through environmental sensibilization and rational use of the existing natural resources. In the area of the track (1.5 ha) alone 352 plants have been identified, totaling 97 different species that are distributed in 36 families. The implementation of the project will contribute to strengthen the relations with the local community, like dwellers, teachers and pupils of the municipal network of Senador Canedo, as well as co-workers of the unit, thus reaffirming the commitment of the company to socio-environmental responsibility. (author)

  20. Scientists from all over the world attend the &apos;&apos;Frederic Joliot/Otto Hahn Summer School 2009&apos;&apos; at the Karlsruhe Institute of Technology (KIT); Wissenschaftler aus aller Welt bei der &apos;&apos;Frederic Joliot/Otto Hahn Summer School 2009&apos;&apos; am Karlsruhe Institute of Technologie (KIT)

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez Espinoza, Victor Hugo; Fischer, Ulrich [Karlsruhe Inst. of Tech. (KIT), Campus Nord/Inst. for Neutron Physics and Reactor Tech. (INR), Eggenstein-Leopoldshafen (Germany)

    2009-11-15

    The &apos;&apos;Frederic Joliot/Otto Hahn Summer School&apos;&apos; is organized each year alternately by the Karlsruhe Institute of Technology and the Commissariat a l&apos;Energie Atomique (CEA), Cadarache. This year&apos;s Summer School, the 15th since its foundation, was run at the Advanced Training Center (FTU) of KIT Campus Nord on August 26 to September 4. The key topic this year was &apos;&apos;The Challenges in Implementing Fast Reactor Technology.&apos;&apos; These are the items discussed: Principles and challenges of future fast reactor designs, Fuels, fuel cycle, and recycling of minor actinides, Innovative cladding tube and structural materials, Special aspects of coolants and the challenges they pose, Fast reactor safety. Experts from 8 leading international research establishments and universities presented and discussed with the 58 participants from 16 countries the current state of the art and the latest development trends in the topics listed above. (orig.)

  1. ApoB/ApoA-1 ratio and nitric oxide levels in pregnancy induced hypertensive women

    Directory of Open Access Journals (Sweden)

    Visala Sree Jammalamadaga

    2016-05-01

    Results: The SBP and DBP were significantly high between 3 groups. The mean plasma TC, TGL, VLDL, LDL, MDA, ApoB levels, ApoB/ApoA-I were significantly high and HDL, ApoA-I, NO, FRAP levels were significantly low between 3 groups. The ApoB/ApoA-I was positively correlated with TC, TGL, VLDL, LDL, malondialdehyde and negatively correlated with HDL, FRAP and NO. Conclusions: Our results indicate that women with PE and E exhibit markedly elevated concentrations of TGL-rich lipoproteins. The negative correlation between ApoB/ApoA-I with NO indicates that the hyperlipidemia is directly related with severity of ED in PIH. So, careful monitoring of ApoB/ApoA-I along with NO might be helpful to predict the onset and progression of the disease. [Int J Res Med Sci 2016; 4(5.000: 1329-1334

  2. &apos;Minergie&apos; modernisation - Test in practice; Praxistest Minergie-Modernisierung

    Energy Technology Data Exchange (ETDEWEB)

    Ruetter, H.; Ruetter-Fischbacher, U. [Ruetter und Partner, Soziooekonomische Forschung und Beratung, Rueschlikon (Switzerland); Haessig, W. [Haessig Sustech GmbH - Ingenieurbuero fuer Minergie und nachhaltige Gebaeudetechnik, Uster (Switzerland); Jakob, M. [TEP Energy GmbH, CEPE ETH, Zuerich (Switzerland)

    2008-07-01

    This comprehensive report for the Swiss Federal Office of Energy (SFOE) examines the results obtained in practice concerning the use of the &apos;Minergie&apos; low energy consumption standard. Experience gained with &apos;Minergie&apos; refurbishment projects is reviewed and the critical points and constraints found are discussed. Further, recommendations for improvements in the use of the &apos;Minergie&apos; standard are made. The study is based on questions posed to building owners in the German speaking part of Switzerland who have carried out refurbishment projects to meet &apos;Minergie&apos; standards as well as questions posed to those who did not adhere to &apos;Minergie&apos; standards in the refurbishment of their buildings. The reasons quoted for using / not using the standard are listed and discussed. Possible tightening of energy regulations concerning renovation work are discussed. The recommendations resulting from the survey are also noted and discussed.

  3. Photoluminescence of acupoint &apos;Waiqiu&apos; in human superficial fascia

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Yuan [Synchrotron Radiation Research Center, Department of Physics, Surface Physics Laboratory (State Key Laboratory) of Fudan University, Shanghai 200433 (China); Yan Xiaohui [Synchrotron Radiation Research Center, Department of Physics, Surface Physics Laboratory (State Key Laboratory) of Fudan University, Shanghai 200433 (China); Liu Chenglin [Synchrotron Radiation Research Center, Department of Physics, Surface Physics Laboratory (State Key Laboratory) of Fudan University, Shanghai 200433 (China); Dang Ruishan [Second Military Medical University, Shanghai 200433 (China); Zhang Xinyi [Synchrotron Radiation Research Center, Department of Physics, Surface Physics Laboratory (State Key Laboratory) of Fudan University, Shanghai 200433 (China) and Shanghai Research Center of Acupuncture and Meridian, Pudong, Shanghai 201203 (China)]. E-mail: xy-zhang@fudan.edu.cn

    2006-07-15

    The spectral characters of an acupuncture point named &apos;Waiqiu&apos; in superficial fascia tissue have been studied by photoluminescence (PL) spectroscopy under the excitation of 457.9 nm. The PL around &apos;Waiqiu&apos; acupuncture point consists of two sub-bands resulting from the flavin adenine dinucleotide (FAD) and phospholipids, and the porphyrins (including purine, isoxanthopterin and tryptophan), respectively. More emission due to FAD and phospholipids is found inside the acupuncture effect area of &apos;Waiqiu&apos; than its marginal or outside acupuncture regions. The ratio of emission intensity of FAD and phospholipids to one of porphyrins gradually decreases along the direction away from the center of the acupuncture point. It implies that the component proportion changes between FAD, phospholipids and porphyrins around the &apos;Waiqiu&apos; acupuncture point. We suggest that there might be a certain relationship between redox function of FAD and &apos;Waiqiu&apos; acupuncture effect.

  4. Finishing report for the &apos;SolcelleInverter&apos; project

    Energy Technology Data Exchange (ETDEWEB)

    Boekhoej Kjaer, S.

    2005-03-01

    The main objective for this research project was to develop an inverter for the AC module, where one PV module is equipped with its own dedicated inverter, and connected to the grid. A topology, among many different candidates, has been selected, based on analysis&apos;s. The inverter has been optimized in respect to cost, reliability, and efficiency, and a prototype has been build. (au)

  5. MRI of &apos;brain death&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Nishino, Shigeki; Itoh, Takahiko; Tuchida, Shohei; Kinugasa, Kazushi; Asari, Shoji; Nishimoto, Akira (Okayama Univ. (Japan). School of Medicine); Sanou, Kazuo

    1990-12-01

    Magnetic resonance imaging (MRI) was undertaken for two patients who suffered from severe cerebrovascular diseases and were clinically brain dead. The MRI system we used was Resona (Yokogawa Medical Systems, superconductive system 0.5 T) and the CT apparatus was Toshiba TCT-300. Initial CT and MRI were undertaken as soon as possible after admission, and repeated sequentially. After diagnosis of brain death, we performed angiography to determine cerebral circulatory arrest, and MRI obtained at the same time was compared with the angiogram and CT. Case 1 was a 77-year-old man who was admitted in an unconscious state. CT and MRI on the second day after hospitalization revealed cerebellar infarction. He was diagnosed as brain dead on day 4. Case 2 was a 35-year-old man. When he was transferred to our hospital, he was in cardiorespiratory arrested. Cardiac resuscitation was successful but no spontaneous respiration appeared. CT and MRI on admission revealed right intracerebral hemorrhage. Angiography revealed cessation of contrast medium in intracranial vessels in both of the patients. We found no &apos;flow signal void sign&apos; in the bilateral internal carotid and basilar arteries on MRI images in both cases after brain death. MRI, showing us the anatomical changes of the brain, clearly revealed brain herniations, even though only nuclear findings of &apos;brain tamponade&apos; were seen on CT. But in Case 1, we could not see the infarct lesions in the cerebellum on MR images obtained after brain death. This phenomenon was caused by the whole brain ischemia masking the initial ischemic lesions. We concluded that MRI was useful not only the anatomical display of lesions and brain herniation with high contrast resolution but for obtaining information on cerebral circulation of brain death. (author).

  6. Contaminación fecal en varios ríos de la Gran Área Metropolitana y la Península de Osa Fecal contamination in several rivers of the Greater Metropolitan Area and the Osa Peninsula

    Directory of Open Access Journals (Sweden)

    Guillermo Calvo Brenes

    2012-12-01

    Full Text Available La contaminación en los ríos de Costa Rica es un problema que merece especial atención. El concepto “contaminación del agua” implica la incorporación de materias extrañas a esta, tales como microorganis- mos (coliformes totales y fecales, productos quími- cos (jabones, fer tilizantes, pesticidas, metales pesados (cromo, plomo, mercurio, etc. o materia orgánica proveniente de los suelos a través de la escorrentía superficial y de las aguas residuales domésticas. Estas materias deterioran la calidad del agua y reducen los diferentes usos que podría tener un río. El recurso hídrico es importante tanto para la preservación de la vida humana como para la conservación de la flora y fauna. Costa Rica se ha caracterizado por ser un país poseedor de una rica biodiversidad. Sin embargo, muchos de los ríos de la Gran Área Metropolitana ya presentan una contaminación severa, según el Índice holandés de clasificación de la calidad del agua. En este estudio se analizó el contenido de colifor- mes fecales en 10 ríos de las provincias de San José, Alajuela, Heredia y Car tago, así como de la Península de Osa. Para correlacionar el contenido de colifor- mes fecales con la densidad poblacional, además, se muestrearon tres puntos en cada río: la zona alta cercana a la naciente, la zona media y la zona baja cercana a su desembocadura. Se encontró que los puntos de muestreo con densi- dades poblacionales medias o altas están altamente contaminados con coliformes fecales.Varios de ellos superan el límite máximo permisible en el contenido de coliformes fecales establecido por los reglamen- tos nacionales para el uso de los ríos en actividades de recreación de contacto primario. También se determinó que las zonas con menor pobla- ción, tales como los ríos Tigre y Rincón en la Península de Osa, el río Poás en Alajuela en todo su recorrido y los ríos Purires y Birrís en Cartago, en sus zonas medias y altas, están menos

  7. Tratamento atual dos miomas Current treatment of leiomyomas

    Directory of Open Access Journals (Sweden)

    Helena von Eye Corleta

    2007-06-01

    Full Text Available Leiomiomas são tumores benignos. Eles surgem no miométrio e contêm quantidade variável de tecido conjuntivo fibroso. Cerca de 75% dos casos são assintomáticos, encontrados ocasionalmente durante exame abdominal, pélvico bimanual ou ultra-sonografia. Os sintomas são relacionados diretamente ao tamanho, ao número e à localização dos miomas. Nessa revisão, são apresentadas as abordagens terapêuticas atuais clínicas (anticoncepcionais orais, progestágenos e antiprogestágenos, análogos do hormônio liberador das gonadotrofinas (GnRH, e antiinflamatórios não esteróides e cirúrgicas (histerectomia, miomectomia e embolização para o tratamento de leiomiomas.Leiomyomas are benign tumors. They appear in the myometrium and present a variable amount of fibrous conjunctive tissue. About 75% of the cases are not symptomatic and are usually found during abdominal, bimanual pelvic examination or during ultrasonography. The symptoms are directly related to the size, number and localization of the myomas. In the present review, the current clinical therapeutic procedures (oral anti-conceptive drugs, progestins and anti-progestins, analogues of the gonadothrophins’ releasing hormone (GnRH, and non-steroid anti-inflammatory drugs, and also the surgical procedures (hysterectomy, myomectomy, embolization are presented for the treatment of leiomyomas.

  8. Tratamento da arterite de Takayasu Takayasu’s arteritis treatment

    Directory of Open Access Journals (Sweden)

    Alexandre Wagner Silva de Souza

    2006-06-01

    Full Text Available A arterite de Takayasu (AT é uma vasculite granulomatosa crônica que envolve a aorta e seus principais ramos. A monitoração da atividade da doença e o melhor esquema terapêutico ainda têm sido um desafio para todos os que tratam estes pacientes. Corticosteróides e imunossupressores vêm sendo utilizados na prática clínica diária com resultados nem sempre animadores. Apesar de não haver estudos controlados que abordem o tratamento da AT, diferentes estudos observacionais descrevem a resposta de pacientes com AT ao uso de corticosteróides, metotrexato (MTX, azatio-prina e ciclofosfamida. Após a introdução da terapia biológica, novas perspectivas têm surgido para os pacientes com AT refratários aos esquemas terapêuticos tradicionais.Takayasus’s arteritis is a chronic granulomatous vasculitis involving the aorta and its main branches. Monitoring disease activity and the choice for the best therapy has been major challenger faced by all physicians who treat these patients. Corticosteroids and immunosuppressive therapy have been used in daily medical practice, but results have not always been encouraging. Although there are no controlled studies evaluating the treatment of Takayasu’s arteritis, observational studies have described the response to the use of corticosteroids, methotrexate, azathioprine and cyclophosphamide. The emerging of biological therapy has brought new perspective for Takayasu’s patients who are refractory to conventional therapy.

  9. Tratamento cirúrgico da cisticircose da fossa craniana posterior

    Directory of Open Access Journals (Sweden)

    Pedro Garcia Lopes

    1971-03-01

    Full Text Available A cisticercose, um dos mais sérios problemas parasitológicos do sistema nervoso, apresenta, quando localizada na fossa posterior, um quadro clínico dramático, no qual predomina a hipertensão intracraniana. Foram estudados neste trabalho, 70 pacientes com cisticercose de fossa craniana posterior, atendidos no Serviço de Neurocirurgia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo de 1945 a 1968. Considerando-se a grande diversidade existente em torno das técnicas de tratamento cirúrgico, foi objetivo deste trabalho o estudo dos resultados obtidos nestes pacientes, nos quais várias técnicas foram empregadas. As cirurgias paliativas que derivam o trânsito do líquido cefalorraqueano para regiões extracranianas, quando comparadas aos outros tipos de cirurgias utilizados, foram as que proporcionaram maior índice de recuperação, exigiram menos reoperações, além de terem sido acompanhadas de menor número de complicações, bem como de menor mortalidade pós-operatória. Por outro lado, a neurocisticercose geralmente é um processo difuso, encontrando-se parasitas em várias regiões do encéfalo e/ou aracnoidite, conforme comprovou-se, também, entre os casos ora reunidos e que vieram a falecer. Baseando-se nestes fatos, não se justificam as derivações intracranianas e, a não ser eventualmente, a abordagem direta do parasita. Os casos estudados permitem cone- tatar, portanto, que as derivações extracranianas, por sua simplicidade e eficácia, apresentam-se, atualmente, como a terapêutica cirúrgica mais propriada à cisticercose de fossa craniana posterior.

  10. Oxigenoterapia hiperbárica para tratamento de feridas

    Directory of Open Access Journals (Sweden)

    Sabrina Meireles de Andrade

    Full Text Available RESUMO Objetivo Descrever os tipos mais frequentes de feridas com indicação para terapia por oxigênio hiperbárico e os resultados obtidos. Método Estudo transversal, realizado em um Centro Hiperbárico localizado na cidade de Salvador, Bahia. Os prontuários de 200 pacientes tratados com oxigênio hiperbárico foram revisados, no período de janeiro a novembro de 2013, analisando-se as variáveis da pessoa, clínicas, indicação, número de sessões e cicatrização da ferida, através de estatística descritiva e teste de associação Qui-quadrado de Pearson com correção de Yates, adotando-se um nível de 5%. Resultados As feridas mais frequentemente encontradas como indicação para terapia por oxigênio hiperbárico foram: úlcera venosa, lesão traumática e pé diabético. Os pacientes com feridas crônicas realizaram um menor número de sessões (61,1% e tiveram suas feridas cicatrizadas ou reduzidas (62,0% quando comparados com aqueles com feridas agudas. Conclusão A terapia por oxigênio hiperbárico é um tratamento efetivo para pacientes com feridas crônicas.

  11. Tratamento de hérnia umbilical em bovinos

    Directory of Open Access Journals (Sweden)

    Luiz Antônio Franco da Silva

    2012-02-01

    Full Text Available Bovinos jovens são frequentemente acometidos por hérnias umbilicais. Neste trabalho, avaliou-se a ocorrência e estabeleceu-se o tratamento cirúrgico para hérnias umbilicais em bovinos jovens, empregando 78 bezerros distribuídos em seis grupos. Em GI e GIV, na laparorrafia, utilizou-se sutura jaquetão; em GII e GV, jaquetão modificado e, em GIII e GVI, sutura separada simples com pontos de relaxamento. Em GI, GII e GIII utilizou-se fio de algodão e, em GIV, GV e GVI, de náilon. Dados não paramétricos, envolvendo a recuperação dos animais e sua independência ou associações com o padrão de sutura foram analisados pelo teste do Qui-quadrado e Exato de Fisher, fazendo-se uso do programa computacional Statistical Analysis System, a 5% (p < 0,05. Os demais resultados foram analisados descritivamente. A ocorrência de hérnia umbilical em bovinos foi expressiva e a herniorrafia, empregando-se fio de algodão, apresentou maiores complicações pós-operatórias; porém a maioria dos animais recuperou-se. O fio e o padrão de sutura, manejo pós-operatório, resposta individual e o tamanho do anel herniário influenciam na reabilitação dos animais e na redução das complicações pós-operatórias.

  12. Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study.

    Directory of Open Access Journals (Sweden)

    Laurence O'Dwyer

    Full Text Available The E4 allele of the ApoE gene has consistently been shown to be related to an increased risk of Alzheimer's disease (AD. The E4 allele is also associated with functional and structural grey matter (GM changes in healthy young, middle-aged and older subjects. Here, we assess volumes of deep grey matter structures of 22 healthy younger ApoE4 carriers and 22 non-carriers (20-38 years. Volumes of the nucleus accumbens, amygdala, caudate nucleus, hippocampus, pallidum, putamen, thalamus and brain stem were calculated by FMRIB's Integrated Registration and Segmentation Tool (FIRST algorithm. A significant drop in volume was found in the right hippocampus of ApoE4 carriers (ApoE4+ relative to non-carriers (ApoE4-, while there was a borderline significant decrease in the volume of the left hippocampus of ApoE4 carriers. The volumes of no other structures were found to be significantly affected by genotype. Atrophy has been found to be a sensitive marker of neurodegenerative changes, and our results show that within a healthy young population, the presence of the ApoE4+ carrier gene leads to volume reduction in a structure that is vitally important for memory formation. Our results suggest that the hippocampus may be particularly vulnerable to further degeneration in ApoE4 carriers as they enter middle and old age. Although volume reductions were noted bilaterally in the hippocampus, atrophy was more pronounced in the right hippocampus. This finding relates to previous work which has noted a compensatory increase in right hemisphere activity in ApoE4 carriers in response to preclinical declines in memory function. Possession of the ApoE4 allele may lead to greater predilection for right hemisphere atrophy even in healthy young subjects in their twenties.

  13. &apos;&apos;Confession statement against the nuclear nation&apos;&apos;. The protestant church in Germany and the conflicts concerning nuclear energy 1970 - 1990; &apos;&apos;Bekennen gegen den Atomstaat&apos;&apos;. Die evangelischen Kirchen in der Bundesrepublik Deutschland und die Konflikte um die Atomenergie 1970-1990

    Energy Technology Data Exchange (ETDEWEB)

    Schuering, Michael [Florida Univ., Gainesville, FL (United States)

    2015-07-01

    The book on &apos;&apos;Confession statement against the nuclear nation&apos;&apos; discusses the conflicts of the protestant church in Germany concerning nuclear energy in 1970 - 1990. The introduction covers the state of research and the historical sources. The following chapters discuss the issues philosophic-ideological fundamentals: atomic energy and theology, the political church, the new protest culture and comparative perspectives: the catholic perspective, Three Mile Island&apos;s shadow.

  14. Behavioral phenotype and BDNF differences related to apoE isoforms and sex in young transgenic mice

    DEFF Research Database (Denmark)

    Reverte, Ingrid; Klein, Anders Bue; Ratner, Cecilia;

    2012-01-01

    , very little information is available on apoE2 genotype. In the present study, we have characterized behavioral and learning phenotypes in young transgenic mice apoE2, apoE3 and apoE4 of both sexes. We have also determined the levels of brain-derived neurotrophic factor (BDNF) and its receptor Trk...... in the exploration of an open-field, which is compatible with a hyperactive behavior, was found in apoE2 females, while a decreased activity was observed in apoE4 mice. Increased BDNF levels in the frontal cortex were observed in apoE2 mice compared to apoE3. These results underscore behavioral differences between...

  15. Energy-related renovation in the world heritage. Retrofitting &apos;Glas-Hoffmann&apos; buildings, Berlin; Energetische Sanierung im Weltkulturerbe. Sanierung &apos;Glas-Hoffmann&apos;-Bauten, Berlin

    Energy Technology Data Exchange (ETDEWEB)

    Brensing, Christian

    2012-11-01

    Between 1955 and 1959, the housing estate at the Schiller park in Berlin-Wedding (Federal Republic in Germany) established in the 1920ies was expanded by four-storey house lines, the so-called Glas-Hoffmann buildings. Since 2008, this ensemble belongs to the Unesco World Heritage. In improving the thermal insulation of the building envelope and the adaptation of the building services to today&apos;s standards, therefore the architectural aesthetics of these buildings should not be endangered. The retrofitting was a pilot project of the research project &apos;&apos;Monument and energy - Postwar Modernism&apos;&apos;.

  16. Functional and morphological parameters with tissue characterization of cardiovascular magnetic imaging in clinically verified &apos;&apos;infarct-like myocarditis&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Schwab, Johannes [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Cardiology and Radiology; Rogg, H.J.; Pauschinger, M.; Fessele, K. [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Cardiology; Bareiter, T.; Baer, I. [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Cardiology and Neuroradiology; Loose, R. [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Radiology

    2016-04-15

    Cardiac magnetic resonance (CMR) has increasingly proved to be a valuable diagnostic tool for evaluating patients with suspected myocarditis. The objective of this study was to evaluate the diagnostic value of functional and morphological parameters including tissue characterization in patients with &apos;&apos;infarct-like myocarditis&apos;&apos;. 43 patients with clinically verified cases of &apos;&apos;infarct-like myocarditis&apos;&apos; (median time to MRI scanning after admission for acute symptoms 3 days) and 35 control patients matched by age and sex were included in this retrospective case control study. In this study we used a 1.5 T MRI scanner conducting steady-state-free-precession sequences, T2-weighted imaging, T1-weighted imaging before and after contrast administration and late gadolinium enhancement sequences. According to the recommendations for CMR diagnosis of myocarditis (Lake Louise consensus criteria), a scan was positive for acute myocarditis if 2 of 3 CMR criteria were present. 30 % of the patients with &apos;&apos;infarct-like myocarditis&apos;&apos; had a reduced left ventricular ejection fraction, 11 % had an increased LV end-diastolic volume index and 35 % had an increased LV mass index. The sensitivity of wall motion abnormalities was 63 % with a regional distribution in 49 %. In 47 % of cases regional wall motion abnormalities were present in the lateral left ventricular segments. Pericardial effusions were discovered in 65 % of cases with a circular appearance in 21 % and focal manifestation in 44 %. The diagnostic sensitivity, specificity, and accuracy of CMR in patients with &apos;&apos;infarct-like myocarditis&apos;&apos; were 67 %, 100 % and 82 %, respectively. The LGE alone was the most sensitive test parameter with 86 %, providing a specificity of 100 % and accuracy of 92 %. Our study results can be applied to the subgroup of patients with &apos;&apos;infarct-like myocarditis&apos;&apos;, where we found that LGE alone was the

  17. Solar students&apos; hostel at Kaiserslautern

    Energy Technology Data Exchange (ETDEWEB)

    Hoffmann, W.; Vangerow-Kuehn, A.

    A students&apos; hostel including 30 living units is being built at the University of Kaiserslautern. Together with the department of biology the students of the department of architecture, regional and environmental planning, civil engineering, are planning an &apos;'alternative'&apos; hostel. It is to be constructed on the university campus in self-construction. The passive utilization of solar energy for the conservation of heating costs is focused in the design planning. The hostel shall be roofed with a standard, low-priced greenhouse construction of a prefabrication degree of 100% and including standardized ventilation devices and blinds.

  18. The location selection act or &apos;the Emperor&apos;s new clothes&apos;; Das Standortauswahlgesetz oder &apos;Des Kaisers neue Kleider&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Feldmann, Ulrike

    2013-10-15

    As is generally known, the governing parties CDU/CSU and FDP agreed a few weeks ago in the 17{sup th} legislative period of the German Bundestag in a rare show of unanimity, together with the parties SPD and Buendnis 90/Die Gruenen, as well as with the Laender, on a &apos;law to search and select a location for a permanent disposal site for heat-generating radioactive waste products and to change other laws&apos;, in brief a location selection act also called StandAG. The law was received with animated approval from the ranks of the parties - with the exception of the (left-wing) party Die Linke. This praise is a tad bewildering, since the Bundesumweltministerium (Federal Department of the Environment) named solving the task within a single generation as one of the principles for the StandAG, and it was emphasised again and again in the debates about the StandAG that the problem of permanent disposal must not be shifted to the next generation. Conclusion: - The StandAG leads to a postponement of solving the permanent disposal site issue by a least several generations with its predictable, long-winded selection method. - The decision not to explore Gorleben conclusively could lead to the site being permanently (&apos;wasted&apos; or) &apos;burned&apos;. - The de-central, interim disposal site Gorleben is likewise &apos;burned&apos; without having a resilient alternative solution for the glass coquilles that must be taken back. - The people&apos;s protest is exponentiated by the number of the potential sites for the StandAG. - The costs for the alternative site search will not be shifted to the producers of the waste that are obliged by law to deliver the waste because of the financial provisions of the constitution. - The third party protection dogma has not been broken up, which will at least lead to delays in the procedure and will have effects on other major projects in the long run. (orig.)

  19. Evaluatie onderzoeksprogramma&apos;s milieutechnologie vanuit een invalshoek stoffen

    NARCIS (Netherlands)

    Lijzen JPA

    1991-01-01

    This study was carried out to determine the need of a separate programme of the &apos;Regulation for the Advancement of Environmental Technology&apos; (&apos;Sti-MT&apos;) to stimulate technology from a substance point of view. Therefore 6 programms of the &apos;Sti-MT&apos; and 5 other technologic

  20. The intern structure of special relativity; La &apos;&apos;structure fine&apos;&apos; de la relativite restreinte

    Energy Technology Data Exchange (ETDEWEB)

    Pierseaux, Y. [Universite Libre de Bruxelles (Belgium)

    1999-07-01

    The author presents the forgotten fact that in 1905 there were 2 restricted theories of relativity: that of Einstein and that of Poincare. These 2 theories were independently formulated, they are very close to each other but are fundamentally different when we consider their basic principles. Poincare&apos;s theory is based on a classical representation of the purely undulatory aspect of light, whereas Einstein stipulates for the quantum aspect of light. Poincare&apos;s theory implies the existence of the ether and asserts the primacy of continuity over discontinuity. The author has based his work on a thorough study of the scientific articles in which Poincare and Einstein explained their ideas. The comparison of these 2 theories sheds light on the evolution of concepts on which the whole modern physics is based. An extended bibliography of works published on special relativity or on related topics is given. (A.C.)

  1. Do &apos;&apos;surrogate emissions&apos;&apos; constitute in-built leakage of the Kyoto Protocol flexible mechanisms?

    Energy Technology Data Exchange (ETDEWEB)

    Kopolo, G.

    2001-11-01

    &apos;Surrogate emissions&apos; is a neologism coined to describe GHG emissions resulting from the production of intermediate goods in developing countries for industrial processing in industrialized countries, especially where the same transnational corporation controls these goods. Where upstream industrial processes extend to other developed countries, the leakage caused by this phenomenon does not arise. This is because all developed countries have QELROs. Thus, all emissions take place within the Annex I area and are covered by the QELROs. However, where the upstream processes ramify into developing countries, the associated GHG emissions are vented off, as it were, into an open system. The paper suggests that, for a complete picture of GHG emissions resulting from the industrial activities of Annex I Parties to the UNFCCC, these surrogated emissions should be incorporated into their national inventories. Otherwise, the emissions trading scheme under the auspices of the Kyoto Protocol would be undermined. (Author)

  2. Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory.

    Science.gov (United States)

    Biundo, Fabrizio; Ishiwari, Keita; Del Prete, Dolores; D'Adamio, Luciano

    2015-12-01

    Mutations in Amyloid β Precursor Protein (APP) and in genes that regulate APP processing--such as PSEN1/2 and ITM2b/BRI2--cause familial dementia, such Familial Alzheimer disease (FAD), Familial Danish (FDD) and British (FBD) dementias. The ApoE gene is the major genetic risk factor for sporadic AD. Three major variants of ApoE exist in humans (ApoE2, ApoE3, and ApoE4), with the ApoE4 allele being strongly associated with AD. ITM2b/BRI2 is also a candidate regulatory node genes predicted to mediate the common patterns of gene expression shared by healthy ApoE4 carriers and late-onset AD patients not carrying ApoE4. This evidence provides a direct link between ITM2b/BRI2 and ApoE4. To test whether ApoE4 and pathogenic ITM2b/BRI2 interact to modulate learning and memory, we crossed a mouse carrying the ITM2b/BRI2 mutations that causes FDD knocked-in the endogenous mouse Itm2b/Bri2 gene (FDDKI mice) with human ApoE3 and ApoE4 targeted replacement mice. The resultant ApoE3, FDDKI/ApoE3, ApoE4, FDDKI/ApoE4 male mice were assessed longitudinally for learning and memory at 4, 6, 12, and 16-17 months of age. The results showed that ApoE4-carrying mice displayed spatial working/short-term memory deficits relative to ApoE3-carrying mice starting in early middle age, while long-term spatial memory of ApoE4 mice was not adversely affected even at 16-17 months, and that the FDD mutation impaired working/short-term spatial memory in ApoE3-carrying mice and produced impaired long-term spatial memory in ApoE4-carrying mice in middle age. The present results suggest that the FDD mutation may differentially affect learning and memory in ApoE4 carriers and non-carriers.

  3. Young physicists&apos; forum

    Energy Technology Data Exchange (ETDEWEB)

    T. Adams et al.

    2001-11-02

    The Young Physicists&apos; Forum was an opportunity for the younger members of the particle-physics community to gather at Snowmass 2001 and to study and debate major issues that face the field over the next twenty years. Discussions were organized around three major topics: outreach and education, the impact of globalization, and building a robust and balanced field. We report on the results of these discussions, as presented on July 17, 2001.

  4. Development of new VOC exposure metrics and their relationship to &apos;&apos;Sick Building Syndrome&apos;&apos; symptoms

    Energy Technology Data Exchange (ETDEWEB)

    Ten Brinke, JoAnn [Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab., Berkeley, CA (United States)

    1995-08-01

    Volatile organic compounds (VOCs) are suspected to contribute significantly to &apos;&apos;Sick Building Syndrome&apos;&apos; (SBS), a complex of subchronic symptoms that occurs during and in general decreases away from occupancy of the building in question. A new approach takes into account individual VOC potencies, as well as the highly correlated nature of the complex VOC mixtures found indoors. The new VOC metrics are statistically significant predictors of symptom outcomes from the California Healthy Buildings Study data. Multivariate logistic regression analyses were used to test the hypothesis that a summary measure of the VOC mixture, other risk factors, and covariates for each worker will lead to better prediction of symptom outcome. VOC metrics based on animal irritancy measures and principal component analysis had the most influence in the prediction of eye, dermal, and nasal symptoms. After adjustment, a water-based paints and solvents source was found to be associated with dermal and eye irritation. The more typical VOC exposure metrics used in prior analyses were not useful in symptom prediction in the adjusted model (total VOC (TVOC), or sum of individually identified VOCs (ΣVOCi)). Also not useful were three other VOC metrics that took into account potency, but did not adjust for the highly correlated nature of the data set, or the presence of VOCs that were not measured. High TVOC values (2--7 mg m-3) due to the presence of liquid-process photocopiers observed in several study spaces significantly influenced symptoms. Analyses without the high TVOC values reduced, but did not eliminate the ability of the VOC exposure metric based on irritancy and principal component analysis to explain symptom outcome.

  5. Development of new VOC exposure metrics and their relationship to &apos;&apos;Sick Building Syndrome&apos;&apos; symptoms

    Energy Technology Data Exchange (ETDEWEB)

    None

    1995-08-01

    Volatile organic compounds (VOCs) are suspected to contribute significantly to &apos;&apos;Sick Building Syndrome&apos;&apos; (SBS), a complex of subchronic symptoms that occurs during and in general decreases away from occupancy of the building in question. A new approach takes into account individual VOC potencies, as well as the highly correlated nature of the complex VOC mixtures found indoors. The new VOC metrics are statistically significant predictors of symptom outcomes from the California Healthy Buildings Study data. Multivariate logistic regression analyses were used to test the hypothesis that a summary measure of the VOC mixture, other risk factors, and covariates for each worker will lead to better prediction of symptom outcome. VOC metrics based on animal irritancy measures and principal component analysis had the most influence in the prediction of eye, dermal, and nasal symptoms. After adjustment, a water-based paints and solvents source was found to be associated with dermal and eye irritation. The more typical VOC exposure metrics used in prior analyses were not useful in symptom prediction in the adjusted model (total VOC (TVOC), or sum of individually identified VOCs ({Sigma}VOC{sub i})). Also not useful were three other VOC metrics that took into account potency, but did not adjust for the highly correlated nature of the data set, or the presence of VOCs that were not measured. High TVOC values (2--7 mg m{sup {minus}3}) due to the presence of liquid-process photocopiers observed in several study spaces significantly influenced symptoms. Analyses without the high TVOC values reduced, but did not eliminate the ability of the VOC exposure metric based on irritancy and principal component analysis to explain symptom outcome.

  6. CT angiography helps to differentiate acute from chronic carotid occlusion: the &apos;&apos;carotid ring sign&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Michel, Patrik; Ntaios, George [Centre Hospitalier Universitaire Vaudois and University of Lausanne, Neurology Service, Lausanne (Switzerland); Delgado, Montserrat G. [Hospital Universitario Central de Asturias, Oviedo (Spain); Bezerra, Daniel C. [Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, Baltimore, MD (United States); Meuli, Reto; Binaghi, Stefano [Centre Hospitalier Universitaire Vaudois and University of Lausanne, Department of Radiology, Lausanne (Switzerland)

    2012-02-15

    Currently, there is no reliable method to differentiate acute from chronic carotid occlusion. We propose a novel CTA-based method to differentiate acute from chronic carotid occlusions that could potentially aid clinical management of patients. We examined 72 patients with 89 spontaneously occluded extracranial internal carotids with CT angiography (CTA). All occlusions were confirmed by another imaging modality and classified as acute (imaging <1 week of presumed occlusion) orchronic (imaging >4 weeks), based on circumstantial clinical and radiological evidence. A neuroradiologist and a neurologist blinded to clinical information determined the site of occlusion on axial sections of CTA. They also looked for (a) hypodensity in the carotid artery (thrombus), (b) contrast within the carotid wall (vasa vasorum), (c) the site of the occluded carotid, and (d) the &apos;&apos;carotid ring sign&apos;&apos; (defined as presence of a and/or b). Of 89 occluded carotids, 24 were excluded because of insufficient circumstantial evidence to determine timing of occlusion, 4 because of insufficient image quality, and 3 because of subacute timing of occlusion. Among the remaining 45 acute and 13 chronic occlusions, inter-rater agreement (kappa) for the site of proximal occlusion was 0.88, 0.45 for distal occlusion, 0.78 for luminal hypodensity, 0.82 for wall contrast, and 0.90 for carotid ring sign. The carotid ring sign had 88.9% sensitivity, 69.2% specificity, and 84.5% accuracy to diagnose acute occlusion. The carotid ring sign helps to differentiate acute from chronic carotid occlusion. If further confirmed, this information may be helpful in studying ischemic symptoms and selecting treatment strategies in patients with carotid occlusions. (orig.)

  7. Depositional &apos;'cyclicity'&apos; on carbonate platforms: Real-world limits on computer-model output

    Energy Technology Data Exchange (ETDEWEB)

    Boss, S.K.; Neumann, A.C. (Univ. of North Carolina, Chapel Hill, NC (United States)); Rasmussen, K.A. (Northern Virginia Community Coll., Annandale, VA (United States))

    1994-03-01

    Computer-models which attempt to define interactions among dynamic parameters believed to influence the development of &apos;'cyclic'&apos; carbonate platform sequences have been popularized over the past few years. These models typically utilize vectors for subsidence (constant) and cyclical (sinusoidal) eustatic sea-level to create accommodation space which is filled by sedimentation (depth-dependent rates) following an appropriate lag time (non-depositional episode during initial platform flooding). Since these models are intended to reflect general principles of cyclic carbonate deposition, it is instructive to test their predictive utility by comparing typical model outputs with an actively evolving depositional cycle on a modern carbonate platform where rates of subsidence, eustatic sea-level and sediment accumulation are known. Holocene carbonate deposits across northern Great Bahama Bank provide such an ideal test-platform for model-data comparisons. On Great Bahama Bank, formation of accommodation space depends on eustatic sea-level rise because tectonic subsidence is very slow. Contrary to typical model input parameters, however, the rate of formation of accommodation space varies irregularly across the bank-top because irregular bank-top topography (produced by subaerial erosion and karstification) results in differential flooding of the platform surface. Results of this comparison indicate that typical computer-model input variables (subsidence, sea-level, sedimentation, lag-time) and output depositional geometries are poorly correlated with real depositional patterns across Great Bahama Bank. Since other modern carbonate platforms and ancient carbonate sequences display similarly complex stratigraphies, it is suggested that present computer-modeling results have little predictive value for stratigraphic interpretation.

  8. Better spent. Towards an &apos;Evidence-based&apos; environmental policy; Beter besteed. Naar &apos;Evidence-based&apos; milieubeleid

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-11-01

    The aim of the &apos;Groene Rekenkamer&apos; (Green Audit Office) is to examine and review the scientific value of white papers, bills and other proposals on different environmental subjects. Also attention will be paid to the suitability, effectiveness and efficiency of laws and regulations with respect to public health and environmental targets and to analyze and clarify possible risks of the implementation of policy (cost benefit analysis) [Dutch] Milieu- en volksgezondheidsregels en -wetten blijken te vaak een zeer beperkte wetenschappelijke basis te hebben. Maatregelen op deze terreinen worden veelal ingegeven door publieke en politieke perceptie in plaats van harde wetenschappelijke gegevens. Met name op het gebied van milieu, ruimtelijke ordening en volksgezondheid heeft dit geleid tot dure, onnodige en soms zelfs contraproductieve maatregelen. De Groene Rekenkamer heeft als doel beleid- en wetsvoorstellen op verschillende terreinen te toetsen aan beschikbare wetenschappelijke gegevens. Daarnaast zal het haar taak zijn de doelmatigheid van wet en regelgeving (in termen van gestelde volksgezondheid en milieudoelen) te analyseren en de mogelijke risico&apos;s van beleidsimplementatie te verhelderen (kosten-baten analyse)

  9. Sintomas de pacientes em tratamento oncológico = Symptoms of patients undergoing oncological treatment

    Directory of Open Access Journals (Sweden)

    Brateibach, Valdecir

    2013-01-01

    Full Text Available Objetivo: Associar sintomas de pacientes em tratamento oncológico com o tipo de tratamento, faixa etária e sexo. Materiais e Métodos: Estudo observacional, transversal e analítico; realizado com 480 pacientes em tratamento atendidos em um Centro de Alta Complexidade de Tratamento para Câncer no Sul do Brasil no período de abril a dezembro de 2011. Resultados: A média de idade dos entrevistados foi de 58,23 (DP=13,11 anos. Os sintomas mais freqüentes nos pacientes em tratamento quimioterápico antineoplásico foram a fadiga e a dor com 78,5%, o que corresponde a 238 pacientes, seguido de constipação e insônia com 51,8% e 47,5%, respectivamente, e principalmente no sexo feminino. Na comparação das médias dos sintomas conforme o tratamento, náuseas e vômitos apresentaram associação com p=0,013, enquanto na comparação dos sintomas com os ciclos de vida náuseas e vômitos apresentaram p=0,05 e 0,24, respectivamente. Conclusão: O estudo evidencia associação estatística dos sintomas náuseas e vômitos com o ciclo de vida e tratamento, e revela maiores queixas entre as mulheres. Estes dados podem ser utilizados na prática assistencial, auxiliando na individualização da assistência

  10. Custos com antimicrobianos no tratamento de pacientes com infecção

    Directory of Open Access Journals (Sweden)

    Adriana Cristina de Oliveira

    2015-09-01

    Full Text Available Introdução: Os custos relacionados ao tratamento antimicrobiano de pacientes com infecções da corrente sanguínea causadas por microrganismos resistentes têm sido pouco explorados. Objetivo:Comparar os custos diretos do tratamento antimicrobiano de pacientes com infecção da corrente sanguínea causada por Staphylococcus aureus resistente e sensível à oxacilina (mrsa e mssa, respectivamente. Metodologia: Tratou-se de uma coorte histórica, realizada em uma unidade de terapia intensiva. Foram incluídos pacientes com infecção da corrente sanguínea por Staphylococcus aureus, entre março de 2007 e março de 2011. Utilizaram-se os registros dos prontuários, da comissão de controle de infecção hospitalar e do sistema de finanças do hospital, sendo realizada análise univariada. Resultados: Fizeram parte do estudo 31 pacientes tanto no grupo infectado por mrsa, quanto naquele infectado por mssa. De acordo com a análise univariada, o direcionamento do tratamento reduziu o espectro de ação dos antibióticos utilizados e os custos (p ; 0,001 e a resistência bacteriana esteve relacionada a um maior gasto com o tratamento antimicrobiano empírico (p = 0,05, não sendo encontrada associação para tratamentos direcionado e total. Conclusão: A resistência bacteriana pode influenciar os custos com tratamento antimicrobiano, sendo necessários mais estudos sobre o tema, avaliando especificamente tratamento antimicrobiano.

  11. Analysis of &apos;&apos;new physics&apos;&apos; in the flavor sector using effective field theory methods

    Energy Technology Data Exchange (ETDEWEB)

    Dassinger, Benjamin M.

    2010-02-05

    The enormous amount of data collected by the B factories as well as the perspective concerning the upcoming experiments at the LHC provide us with the opportunity to perform high precision tests of the standard model. This dissertation presents two model independent precision tests of the weak sector of the standard model using extensions of the weak currents which are set up using effective field theory methods in order to control the size of the different contributions. Constraints on the coefficients of the terms can then be obtained by comparison with experimental results. The first analysis incorporates a test of the lefthandedness of the weak interaction in the quark sector. By introducing additional weak couplings the differential and total decay rates of the inclusive semileptonic decay anti B {yields} X{sub c}l anti {nu}{sub l} are calculated. The calculation includes the computation of the heavy-quark expansion which describes the interaction of the decaying b quark with respect to the background field of the B meson, up to order 1/m{sub b}{sup 4}. This has been done in a new, systematic way which does not involve the calculation of gluon matrix elements. Furthermore, radiative corrections have been included up to order O({alpha}{sub s}) including renormalization group running. The second part deals with the introduction of lepton flavor violating operators in the context of leptonic {tau} decays. These operators give rise to the effective four-fermion vertex {tau}{yields}ll{sup &apos;}l'&apos; as well as the subsequent radiative decay {tau}{yields}l{gamma}{sup *}{yields}ll{sup &apos;+}l{sup &apos;-}. The resulting Dalitz distributions turn out to predict completely different signatures for the radiative and the effective four-fermion vertices and provide the opportunity to check, whether the decay is induced either by a radiative or by an effective four-fermion vertex. Since different models which contain lepton flavor violation are normally more

  12. Mothers&apos; Beliefs about Children&apos;s Learning in Hong Kong and the United States: Implications for Mothers&apos; Child-Based Worth

    Science.gov (United States)

    Ng, Florrie Fei-Yin; Pomerantz, Eva M.; Lam, Shui-fong

    2013-01-01

    Chinese and American mothers&apos; beliefs about children&apos;s learning and parents&apos; role in it were examined using notions salient in Chinese culture. Mothers from Hong Kong ("n" = 66) and the United States ("n" = 69) indicated their endorsement of the ideas that children&apos;s learning reflects children&apos;s…

  13. IPSN activity report 1999; Rapport d&apos;activite de l&apos;IPSN 1999

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    The &apos;&apos;Institut de Protection et de Surete Nucleaire&apos;&apos; (IPSN), carries out researches and expert studies needed to manage nuclear risks and their consequences on people and environment. These activities cover the installation safety, the radioactive matter transport, the public health and environmental control, the nuclear matters safety and control and the crisis situation management. The IPSN have got also a mission of public information and participates to international actions in the domain of scientific researches or expert&apos;s report. This annual report presents the highlights of the year 1999, information on staff, budgets and geographical situation. Then technical and scientific papers gathers the activities of the year covered by the IPSN: the &apos;&apos;Free Tribune&apos;&apos;, installations and radioactive wastes safety, crisis and nuclear matter management, public health and environment control, international cooperation. (A.L.B.)

  14. ANDRA&apos;s news; L&apos;actualite de l&apos;Andra

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This press kit presents the three missions of the French national agency of radioactive wastes (ANDRA) and the main highlights of these three missions for the second half of 2003: 1 - industrial mission: the very low radioactive waste disposal facility of Morvilliers (543 m{sup 3} of waste packages already stored), the Aube disposal facility (exploitation data), the Manche disposal facility (adaptation to new monitoring standards); 2 - the research mission: the Meuse/Haute-Marne laboratory (progress of works and experimental program), the mobilization of competences (international expertise of ANDRA&apos;s researches about deep underground disposal, the coordination of the European program ESDRED); 3 - the information mission: national inventory of radioactive wastes, publications and events, recall of ANDRA&apos;s missions. (J.S.)

  15. Formation of helium induced nanostructure &apos;fuzz&apos; on various tungsten grades

    Energy Technology Data Exchange (ETDEWEB)

    Baldwin, M.J., E-mail: mbaldwin@ferp.ucsd.ed [Center for Energy Research and Department of Mechanical and Aerospace Engineering, University of California-San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0417 (United States); Doerner, R.P. [Center for Energy Research and Department of Mechanical and Aerospace Engineering, University of California-San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0417 (United States)

    2010-09-30

    The response of a variety of W material grades to nanostructure &apos;fuzz&apos; formation is explored. W targets are exposed to He or D{sub 2}-0.2He plasmas in PISCES-B at 900-1320 K to below sputter threshold He{sup +} ions of energy 25-60 eV for up to 2.2 x 10{sup 4} s. SEM and XPS reveal nanoscopic reorganization of the W surface to a layer of &apos;fuzz&apos; of porosity {approx}90% as determined by a &apos;fuzz&apos; removal/weight loss method. The variability of &apos;fuzz&apos; growth is examined at 1120 K for 1 h durations: SR, SC and doped W grades - La{sub 2}O{sub 3} (1% wt.), Re (5% and 10% wt.), and TiC (1.5% wt.) developed 2-3 {mu}m thick &apos;fuzz&apos; layers, while a VPS grade developed a layer 4 {mu}m thick. An RC grade revealed additional &apos;fuzz&apos; at deep (>100 {mu}m) grain boundaries. However, heat treatment up to 1900 K produced reintegration of &apos;fuzz&apos; with the bulk and He release at {approx}1000 K and {approx}1400-1800 K due to depopulation from vacancy complexes.

  16. Scenarios for an integrated sustainability policy - using the example of the &apos;&apos;Sustainable City 2030&apos;&apos;. Vol. 2; Szenarien fuer eine integrierte Nachhaltigkeitspolitik - am Beispiel: Die nachhaltige Stadt 2030. Bd. 2. Teilbericht &apos;&apos;Kreislaufstadt 2030&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Verbuecheln, Maic; Grabow, Busso; Uttke, Angela; Schwausch, Mandy [Deutsches Inst. fuer Urbanistik (DiFu), Berlin (Germany); Gassner, Robert [Institut fuer Zukunftsstudien und Technologiebewertung gGmbH (IZT), Berlin (Germany)

    2013-04-15

    The partial report &apos;&apos;Recycling City 2030&apos;&apos; was prepared for the Federal Environment Agency (Dessau, Federal Republic of Germany) as a part of the project &apos;&apos;Scenarios for an integrated sustainability policy - the example of &apos;The Sustainable City 2030 &apos;'&apos;. This partial report is based on research activities of the German Institute of Urban Affairs (Berlin, Federal Republic of Germany) and Institute for Futures Studies and Technology Assessment (Berlin, Federal Republic of Germany). The objectives of this partial report are: (1) Description of the challenges and trends in urban regions; (2) Recycling city and its importance in the current debate on sustainability; (3) Identification and optimization of existing cycle approaches in urban habitats; (4) Analysis of the actual state as well as designation of developments and constraints; (5) Discussion on the interface between the sectors; (6) Options for action for the interaction between the actors in interdisciplinary topics; (7) Outline of ways and perspectives of the implementation of the &apos;&apos;Recycling City 2030&apos;&apos;.

  17. Diagnóstico e tratamento das lombalgias e lombociatalgias

    Directory of Open Access Journals (Sweden)

    AV Brazil

    2004-12-01

    Full Text Available DESCRIÇÃO DO MÉTODO DE COLETA DE EVIDÊNCIAS: Reunião consensual e multidisciplinar para elaboração do texto com inclusão das citações bibliográficas, numa colaboração das especialidades de reumatologia, ortopedia e traumatologia, neurocirurgia, radiologia, medicina física e reabilitação e patologia da coluna vertebral. A partir de um texto básico referencial elaborado pelo editor médico, os participantes, divididos em cinco grupos de trabalho, geraram, por acréscimos e subtrações ao texto básico, recomendações aprovadas, posteriormente, em plenária, que permitiram a edição de um texto preliminar. O documento do consenso foi veiculado pela Internet, para consulta pública, tendo recebido várias sugestões e comentários de especialistas no assunto. As propostas foram devidamente avaliadas por uma comissão julgadora e revisora, que selecionou as que foram incorporadas ao texto preliminar. O editor médico, a partir da versão revisada, chegou ao texto final publicado, que recebeu da Biblioteca Nacional o ISBN n° 85-901548-1-5. Uma versão resumida do referido consenso, com algumas adequações, foi elaborada em trabalho colaborativo entre o editor médico e a comissão técnica do projeto diretrizes AMB/CFM. GRAU DE RECOMENDAÇÃO E FORÇA DE EVIDÊNCIA: A: Grandes ensaios clínicos aleatorizados e meta-análises. B: Estudos clínicos e observacionais bem desenhados. C: Relatos e séries de casos clínicos. D: Publicações baseadas em consensos ou opiniões de especialistas. OBJETIVOS: Oferecer informações sobre o diagnóstico e tratamento das lombalgias e lombociatalgias. PROCEDIMENTOS: Diagnósticos e terapêuticos para as lombalgias e lombociatalgias.

  18. Compressed &apos;energy logs&apos;; Energiatukit tulevat

    Energy Technology Data Exchange (ETDEWEB)

    Fredriksson, T.

    1999-07-01

    In Sweden the utilization of forest fuels exceeds 5 million m{sup 3}/a. Two different solutions have been developed for compacting of the logging residues of final fellings. The operating principles of these methods differ from each other. Both these methods compress logging residues to &apos;energy logs&apos;, which can be processed and transported by ordinary forest machines and lorries, used for harvesting of timber. Fiberpack Ab has developed a machine which can compress logging residues or trees without any larger restrictions for raw material. Long tops and trees under 30 cm diameter can be compressed into cylindrical pieces, the diameter of which are 0.7 m, while the length can be defined freely. However, in practical operation the length is usually 3.2 m which enables in long-distance transportation the full load of a timber-lorry. In principle the Fiberpack can produce as long energy log as the amount of logging residues enable. Transportation defines the length of the log. Fiberpac-unit weights six tons, and the width in operational condition is 5.8 m. The length of the unit is 2.4 m and the height 1.9 m. The operation of the equipment has been reliable. Compacting of the logging residues occurs in three stages. In pre-compassion the residues are compressed between two rollers, in the second stage it is compressed further in square-shaped frame, after which it undergoes final compression and binding. The average weight of the &apos;logs&apos; is 550 kg. A normal timber-trailer takes 65-70 logs. The production of Fiberpac is 15-20 logs per hour. Frozen and snowy raw material is the hardest raw material, but both fresh and dried logging residues can be used for production of logs. The price of one Fiberpac-unit is about 1.4 million SEK. Another alternative is the machine developed by Wood Pac Ab, which resembles a cigarette roller. A medium-sized forest machine is used as the basic machine. The minimum power demand is 120 kW, and the efficiency of the

  19. Reply to &apos;&apos;Comment on &apos;Paramagnetic and ferromagnetic resonance studies on dilute magnetic semiconductors based on GaN&apos; &apos;&apos; [Phys. Status Solidi A 205, 1872 (2008)

    Energy Technology Data Exchange (ETDEWEB)

    Kammermeier, T. [Institut fuer Energie und Umwelttechnik e.V. (IUTA), Luftreinhaltung and Nachhaltige Nanotechnologie Unit, Bliersheimer Strasse 60, 47229 Duisburg (Germany); Fakultaet fuer Physik und CeNIDE, Universitaet Duisburg-Essen, 47057 Duisburg (Germany); Ney, A. [Fakultaet fuer Physik und CeNIDE, Universitaet Duisburg-Essen, 47057 Duisburg (Germany); Wieck, A.D. [Angewandte Festkoerperphysik, Ruhr-Universitaet Bochum, Universitaetsstr. 150, NB Building, 44780 Bochum (Germany)

    2011-08-15

    In a comment by Gehlhoff et al. on our work on &apos;&apos;Paramagnetic and ferromagnetic resonance studies on dilute magnetic semiconductors based on GaN&apos;&apos; [Phys. Status Solidi A 205, 1872 (2008)] the authors claim a contradictory explanation of angular dependent magnetic resonance measurements. Here we discuss their - solely based on computer simulations - claims. We show that an interpretation limited on magnetic impurities can hardly be used to explain the complex magnetic behavior. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  20. Know-how management &apos;&apos;Rock mechanics and support methods for the gate roads in the German coal mining industry&apos;&apos;; Wissensmanagement &apos;&apos;Gebirgsmechanik und Ausbautechnik fuer Floezstrecken im deutschen Steinkohlenbergbau

    Energy Technology Data Exchange (ETDEWEB)

    Junker, M. [Deutsche Steinkohle AG, Herne (Germany). Servicebereich Technik und Logistik; Schmidt, R.

    2006-03-23

    The R+D-project for establishment of a database with the entire know-how of the last 30 years from the &apos;&apos;Rock mechanics and support methods for gate roads in the German coal mining industry&apos;&apos; has so far been carried out as planned. After adaptation to the project the selected computer system was introduced. A planning module with recorded operational cases and a structured literature database is thus available to the Competence Centre for Road Supports in the Mining Technology Department of the Technology and Logistics Service Division of DSK. (Orig.)

  1. OJT. make &apos;em or break &apos;em

    Energy Technology Data Exchange (ETDEWEB)

    Arner, S.A.

    1992-01-01

    On-the-job training (OJT) has been with us in varying forms for longer than perhaps any other type of training. In reality, OJT is a process for accomplishing change; change in an employee&apos;s ability to perform assigned job duties. However, bringing about that change can often be a difficult process. A clear understanding of what change really is and what it entails is essential to easing its process. this document discusses the methodology in OJT and emphasizes the importance of communications in this process.

  2. Adesão de pessoas com diabetes mellitus tipo 2 ao tratamento medicamentoso

    Directory of Open Access Journals (Sweden)

    Lilian Cristiane Gomes-Villas Boas

    2014-04-01

    Full Text Available Estudo seccional de abordagem quantitativa que objetivou avaliar a adesão ao tratamento medicamentoso entre pessoas com diabetes mellitus, e sua relação com variáveis clínicas, de tratamento e controle metabólico. A amostra constituiu-se de 162 pessoas com diabetes mellitus tipo 2 em seguimento ambulatorial. Para a coleta dos dados, foram utilizadas a Medida de Adesão aos Tratamentos e a consulta aos prontuários dos participantes. Obteve-se elevada adesão ao tratamento medicamentoso. Para um p<0,05, obteve-se correlação inversa com a pressão arterial diastólica e correlação direta com a frequência diária de administração de insulina e de antidiabéticos orais. Não houve correlações estatisticamente significantes entre adesão e variáveis de controle metabólico. Os resultados divergem da literatura no que se refere à taxa de adesão ao tratamento medicamentoso em doenças crônicas, bem como na correlação entre adesão e complexidade do regime medicamentoso, o que aponta para a necessidade de mais estudos sobre essa temática.

  3. Tratamento cirúrgico da cifose patológica Surgical treatment of pathological kyphosis

    Directory of Open Access Journals (Sweden)

    Helton Luiz Aparecido Defino

    2002-03-01

    Full Text Available Foram estudados 13 pacientes com cifose patológica de diferentes etiologias (Doença de Scheuermann, espondilite anquilosante, congênita, tuberculose vertebral, sequela de laminectomia e síndrome de Morquio, que foram submetidos ao tratamento cirúrgico. A cifose pré-operatória variou de 75 a 100 graus (média 73,3 graus e a média dos valores após o tratamento cirúrgico foi de 42,3 graus. O tipo de tratamento realizado estava relacionado com as características da cifose (raio longo ou curto, flexibilidade e magnitude, e são apresentadas as diferentes técnicas e filosofia de tratamento dos autores para o tratamento cirúrgico dessa modalidade de deformidade vertebral.Thirteen patients with pathologic kyphosis from different ethiologies (Scheuermann's disease, ankylosing spondilitis, congenital, vertebral tuberculosis, post laminectomy and Morquio's syndrome who underwent surgical treatment were studied. Preoperative kyphosis ranged from 75° to 100° (average 73.3° and postoperatively averaged 42.3°. The treatment performed was based on kyphosis characteristics (long or short radius, flexibility, magnitude. The different techniques are presented as well as authors' philosophy for surgical treatment of this kind of vertebral deformity.

  4. Aids to decision in selection of valve stem seals in accordance with the &apos;&apos;TA Luft&apos;&apos; requirements, 2002 edition; Entscheidungshilfen fuer die Auswahl von Spindelabdichtungen nach TA-Luft-Anforderungen - Ausgabe 2002

    Energy Technology Data Exchange (ETDEWEB)

    Wodara, G. [Phoenix Armaturen Werke Bregel GmbH, Volkmarsen (Germany)

    2005-12-01

    &apos;&apos;TA Luft&apos;&apos; (&apos;&apos;Technical Directive for Prevention of Air Pollution&apos;&apos;), 2002, specifies high-quality-sealing metal bellows with a downstream safety gland, or equivalent sealing systems, for the sealing of valva stems. According to &apos;&apos;TA Luft&apos;&apos;, sealing systems may be considered equivalent provided the temperature-specific rates of leakage are met in the VDI 2440 (November, 2000 edition) test and detection procedure. &apos;&apos;High-quality metal bellows with downstream safety gland&apos;&apos; and various &apos;&apos;spring-load gland packings&apos;&apos; are examined in this article on the criterion of the requirements of &apos;'TA-Luft'&apos;, on the bases of testing in accordance with TA Luft 2002 VDI 2440 and a test in accordance with DIN EN ISO 15 848, Part 1. The result: There is, for the bello with downstream safety gland, no alternative which fulfills all the requirements of &apos;&apos;TA Luft&apos;&apos;. The spring-loaded gland packing and, according to the relevant literature, the double gland packing with barrier fluid and exhausting, which is not examined here, do provide a potential alternative for lower load-cycle numbers. The fact that design specifications and the packing and valve manufacturers&apos; installation instructions were taken into account for valve stem surfaces, gap tolerances, packing-ring arrangement, and tightening torques for precompression and final compression, was decisive for fulfillment of the requirements of TA Luft, VDI 2440 in the tests examined in this article. (orig.)

  5. The Visionary&apos;s Dilemma

    Energy Technology Data Exchange (ETDEWEB)

    WALSH,STEVE; MYERS,DAVID R.; SUMPTER,CAROL W.; JAKUBCZAK II,JEROME F.

    2001-10-12

    Novel technologies often are born prior to identifying application arenas that can provide the financial support for their development and maturation. After creating new technologies, innovators rush to identify some previously difficult-to-meet product or process challenge. In this regard, microsystems technology is following a path that many other electronic technologies have previously faced. From this perspective, the development of a robust technology follows a three-stage approach. First there is the &apos;&apos;That idea will never work.&apos;&apos; stage, which is hurdled only by proving the concept. Next is the &apos;&apos;Why use such a novel (unproven) technology instead of a conventional one?&apos;&apos; stage. This stage is overcome when a particular important device cannot be made economically--or at all--through the existing technological base. This initial incorporation forces at least limited use of the new technology, which in turn provides the revenues and the user base to mature and sustain the technology. Finally there is the &apos;&apos;Sure that technology (e.g., microsystems) is good for that product (e.g., accelerometers and pressure sensors), but the problems are too severe for any other application&apos;&apos; stage which is only overcome with the across-the-board application of the new technology. With an established user base, champions for the technology become willing to apply the new technology as a potential solution to other problems. This results in the widespread diffusion of the previously shunned technology, making the formerly disruptive technology the new standard. Like many technologies in the microelectronics industry, the microsystems community is now traversing this well-worn path. This paper examines the evolution of microsystems technology from the perspective of Sandia National Laboratories&apos; development of a sacrificial surface micromachining technology and the associated infrastructure.

  6. Search for B Meson Decays to eta&apos; eta&apos; K

    Energy Technology Data Exchange (ETDEWEB)

    Aubert, B.

    2006-05-05

    The authors describe searches for decays of B mesons to the charmless final states {eta}&apos;{eta}&apos;K. The data consist of 228 million B{bar B} pairs produced in e{sup +}e{sup -} annihilation, collected with the BABAR detector at the Stanford Linear Accelerator Center. The 90% confidence level upper limits for the branching fractions are {Beta}(B{sup 0} {yields} {eta}&apos;{eta}&apos;K{sup 0}) < 31 x 10{sup -6} and {Beta}(B{sup +} {yields} {eta}&apos;{eta}&apos;K{sup +}) < 25 x 10{sup -6}.

  7. U-Pb zircon geochronology of &apos;'brasiliano'&apos; granitoids from the Serido orogenic belt (Borborema Province, NE Brazil). Ages U-Pb sur zircon de granitoides &apos;'brasilianos'&apos; de la ceinture du Serido (Province Borborema, NE Bresil)

    Energy Technology Data Exchange (ETDEWEB)

    Leterrier, J.; Bertrand, J.M. (Centre National de la Recherche Scientifique (CNRS), 54 - Nancy (France). Centre de Recherches Petrographiques et Geochimiques); Pin, C. (Clermont-Ferrand-2 Univ., 63 - Aubiere (France)); Jardim de Sa, E.

    1994-06-01

    Diorites previously attributed to an early stage of the &apos;brasiliano&apos; plutonic evolution of the Serido belt yielded U-Pb zircon age of 579 [+-]7 Ma. The age of associated granites is slightly younger although a synchronous emplacement of granites and diorites is suggested by field relationships. Such an age difference may result from difficulties to distinguish &apos;crystallization age&apos; from &apos;emplacement age&apos;, which is still to be determined precisely. (authors). 16 refs., 3 figs., 1 tab.

  8. PubliForum &apos;Electricity and Society&apos;. Citizen Panel Report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-06-01

    In the Citizen Panel&apos;s Report on &apos;Electricity and Society&apos; we present the first results of three intensive week-ends. In this document, 27 Swiss citizens have recorded their opinions on the future of our electricity supply system. Solutions are sought without making claims on having found the ultimate recipe. The recommendations are the result of an assessment made by a representative cross-section of the public - one could almost say &apos;the voice of the people&apos;. They reflect not only the public&apos;s apprehensions and worries, but also their ideas and desires. (authors)

  9. Tratamento cirúrgico das valvopatias: Parte 3

    Directory of Open Access Journals (Sweden)

    Domingo M Braile

    Full Text Available Este trabalho, subdividido em três partes, apresentou breve histórico da cirurgia cardíaca, com ênfase a cirurgia valvar e substitutos valvulares, empregados com sucesso na década de 60, inicialmente com próteses mecânicas, seguidas pelas heterólogas após a introdução do glutaraldeído para preservação dos tecidos biológicos. As indicações básicas para operar lesões valvares consistem em alívio dos sintomas, prevenção das complicações e da mortalidade. Foram descritos, também, na primeira parte da publicação, aspectos da indicação cirúrgica, com ênfase em estenose e insuficiência das valvas mitral, aórtica, tricúspide e pulmonar, endocardite infecciosa ativa e da conduta pré-operatória, além da caracterização das diferentes próteses valvulares cardíacas mecânicas e biológicas existentes no mercado e suas complicações mais freqüentes. O tratamento cirúrgico das valvopatias, incluindo técnica operatória para troca de valvas mitral, aórtica, tricúspide e pulmonar, condutas anestésica e pós-operatória e reoperações foram abordados na segunda parte da publicação. O trabalho foi concluído considerando as situações especiais, como tratamento cirúrgico na endocardite em valvas mitral, tricúspide e aórtica, cuja incidência é maior que na mitral e a causa mais comum de insuficiência aórtica aguda. O desenvolvimento da endocardite tem fisiopatologia diferente quando comparado às próteses e valvas naturais, com morbi-mortalidade maior que a observada nas valvas nativas. Existem fatores que aumentam o risco de endocardite em valva nativa, raça negra, próteses mecânicas, sexo masculino e longo tempo de circulação extracorpórea. A interação clínico-cirúrgica parece influenciar de forma decisiva na obtenção de melhores resultados para essa lesão. Finalmente, foi registrada a nossa experiência com próteses biológicas em posição mitral e aórtica com 11 e 10 anos de seguimento

  10. Measuring Beliefs in Centimeters: Private Knowledge Biases Preschoolers&apos; and Adults&apos; Representation of Others&apos; Beliefs

    Science.gov (United States)

    Sommerville, Jessica A.; Bernstein, Daniel M.; Meltzoff, Andrew N.

    2013-01-01

    A novel task, using a continuous spatial layout, was created to investigate the degree to which (in centimeters) 3-year-old children&apos;s ("N" = 63), 5-year-old children&apos;s ("N" = 60), and adults&apos; ("N" = 60) own privileged knowledge of the location of an object biased their representation of a…

  11. Dat&apos;a&apos; RTE - &apos; Balance Responsible data &apos; Service. You would like to manage your activities more effectively, and that&apos;s why RTE is offering new services that give you access to personalized data; Dat&apos;a&apos; RTE offre &apos;&apos;donnees de responsable d&apos;equilibre'&apos;. Vous souhaitez mieux piloter vos activites, RTE vous propose un nouveau service de mise a disposition de donnees personnalisees

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-06-01

    RTE, the French manager of the power transportation network, already offers a service under which it publishes public data on its web site ; it aims to improve the way the electricity market works in a transparent and nondiscriminatory fashion. To better respond to the needs of actors in the electricity market, RTE has developed new Dat&apos;a&apos; RTE services, giving them access to detailed, personalized and confidential data. Dat&apos;a&apos; RTE is the main electronic channel used for exchanging personalized data between RTE and customers. The &apos;Balance Responsible Data&apos; service completes and enhances the other services associated with the &apos;Balance Responsible Entity&apos; service. For a detailed picture and greater reactivity, the customers have access to the basic data used to calculate imbalances as soon as they are processed by RTE. They become definitive from the point in time specified in the Balance Responsible Entity contractual documents. The price of this service is dependent upon the size of the customer&apos;s Balance Responsible perimeter.

  12. 3&apos;,8&apos;&apos;-biisokaempferide, a cytotoxic biflavonoid and other chemical constituents of Nanuza plicata (Velloziaceae)

    Energy Technology Data Exchange (ETDEWEB)

    Pinto, Meri Emili F.; Silva, Marcelo Sobral da; Barbosa Filho, Jose Maria; Castello-Branco, Marianna Vieira S.; Agra, Maria de Fatima; Tavares, Josean Fechine, E-mail: marcelosobral@ltf.ufpb.b [Universidade Federal da Paraiba (UFPB), Joao Pessoa, PB (Brazil). Lab. de Tecnologia Farmaceutica; Schindler, Elisabete; El-Bacha, Ramon dos Santos [Universidade Federal da Bahia (UFBA), Salvador, BA (Brazil). Inst. de Ciencias da Saude. Lab. de Neuroquimica e Biologia Celular

    2010-07-01

    A novel biflavonoid, named 3&apos;,8&apos;&apos;-biisokaempferide (1), along with the known compounds amentoflavone (2), patagonic acid (3), (4aR,5S,6R,8aR)-5-[2-(2,5-Dihydro-5-methoxy-2-oxofuran- 3-yl)ethyl]-3,4,4a,5,6,7,8,8a-octahydro-5,6,8a- trimethylnaphthalene-1-carboxylic acid (4), 5-caffeoylquinic acid methyl ester (5), 3,5-di-caffeoylquinic acid (6) and luteolin (7), were isolated of the leaves from Nanuza plicata. The compounds 3, 4, 5 and 6 are reported for the first time in Velloziaceae. The structures of the compounds were elucidated on the basis of spectroscopic methods, especially NMR and MS analyses. The cytotoxicity of 3&apos;,8&apos;&apos;-biisokaempferide was studied in cultures of human glioblastoma GL-15 cells. The effective concentration, which killed 50 % of cells after 72 h was 36.5 {mu}mol L{sup -1}. Changes in cellular morphology, including retraction and degradation of cytoplasm, were observed when cells were treated with concentrations from 20 {mu}mol L-1 of 3&apos;,8&apos;&apos;-biisokaempferide for 72 h. (author)

  13. The role of bioenergy in the energy transition. The &apos;&apos;Smart Bioenergy&apos;&apos; concept; Die Rolle der Bioenergie in der Energiewende. Das &apos;&apos;Smart Bioenergy&apos;&apos;-Konzept

    Energy Technology Data Exchange (ETDEWEB)

    Thraen, Daniela [Helmholtz-Zentrum fuer Umweltforschung - UFZ, Leipzig (Germany). Dept. Bioenergie (BEN); DBFZ Deutsches Biomasseforschungszentrum gGmbH, Leipzig (Germany). Bereich Bioenergiesysteme; Seitz, Stefanie B.; Wirkner, Ronny; Nelles, Michael [DBFZ Deutsches Biomasseforschungszentrum gGmbH, Leipzig (Germany). Bereich Bioenergiesysteme

    2016-08-01

    The energy system&apos;s transformation away from fossil and therefore finite resources and ecological harmful use towards renewable energy sources and sustainable forms of usage proceeds. But even after 35 years, the German energy transition has yet not reached its ambitious goals. Moreover, in the recent years the progress has stagnated in certain areas. This is due to the fact that one of the central challenges of the energy system&apos;s changeover to an sole use renewable energy (RE) have not yet mastered: the reliable and stable delivery of RE for all energy dependent sectors starting form electricity via heat to mobility in the face of fluctuating energy sources like sun and wind. Bioenergy with its flexible use of innovative technologies and smart integration in the overall system is therefore vital to grant stability of energy supply. Furthermore, bioenergy can recourse on sustainable resources and may become therefore the backbone of the future bioeconomy. For this purpose an integrative approach is necessary that aligns the aforementioned building blocks in a cohesive whole: the Smart Bioenergy concept - that will be presented here with its elements but also open questions and challenges.

  14. ApoE plasma levels and risk of cardiovascular mortality in old age.

    Directory of Open Access Journals (Sweden)

    Simon P Mooijaart

    2006-06-01

    Full Text Available BACKGROUND: The epsilon2, epsilon3, and epsilon4 alleles of the apolipoprotein E gene (APOE encode three isoforms, apoE2, E3, and E4, respectively. The apoE isoforms circulate in different plasma concentrations, but plasma concentrations of the same isoform also differ between individuals. Whereas the isoforms have been associated with cardiovascular disease, the relation between plasma apoE levels and cardiovascular disease is unknown. METHODS AND FINDINGS: We assessed APOE genotypes, plasma levels of apoE, cardiovascular risk factors, and mortality in a population-based sample of 546 individuals aged 85 y who participated in the Leiden 85-plus Study and were prospectively followed for specific causes of death for 5 y. Participants in the highest tertile of apoE levels suffered a twofold-increased risk of cardiovascular mortality (hazard ratio compared to lowest tertile, 2.08; 95% confidence interval [CI], 1.30 to 3.33. Among the 324 participants with the epsilon3epsilon3 genotype, the hazard from cardiovascular disease was threefold increased (highest versus lowest tertile 3.01; 95% CI 1.60 to 5.66, with similar estimates for men and women. Other causes of death were not increased significantly. Plasma levels of apoE in epsilon3epsilon3 participants were positively correlated with total cholesterol (p < 0.001, low-density lipoprotein cholesterol (p < 0.001 and triglycerides (p < 0.001 and negatively with high-density lipoprotein cholesterol levels (p = 0.010. Adjustment for plasma lipids did not change the hazard ratios, whereas interaction was absent. The risk associated with high levels of apoE, however, was strongest in participants from the lowest tertile of C-reactive protein (CRP levels and absent in those from the highest tertile (p(interaction < 0.001. Among participants from the lowest tertile of CRP levels, those with a high apoE levels had a significantly steeper increase in CRP than those with low apoE levels (p = 0.020. Similar

  15. Active pollution reduction in the &apos;off-road&apos; sector. Proceedings; Aktive Schadstoffminderung im &apos;Off-road&apos; Bereich. Tagungsband

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The state of the art and trends in off-gas purification and filters were gone into. The focus was on technical aspects, performance information and cost of diesel engines with high-efficiency exhaust purification systems as well as on sulfur-free fuels. [German] Mit der Tagung &apos;Aktive Schadstoffminderung im &apos;'Off-road'&apos; Bereich&apos; bieten wir eine besondere Gelegenheit zur Information und Auseinandersetzung mit dem derzeitigen Stand und den Entwicklungsperspektiven der Abgasreinigung und Filtertechnik bei Neubeschaffungen und in der Nachruestung. Gerade in staedtischen Ballungsgebieten, aber auch in geschlossenen Raeumen und Produktionshallen sind die Reduzierung der lokalen Emissionen und Vermeidung von Geruchsbelaestigungen unabdingbar. Im Mittelpunkt stehen Technik, Betriebserfahrungen und Kosten von Dieselmotoren mit hocheffizienter Abgasreinigung sowie schwefelfreie Kraftstoffe. (orig.)

  16. Holistic oil field value management: using system dynamics for &apos;intermediate level&apos; and &apos;value-based&apos; modelling in the oil industry

    Energy Technology Data Exchange (ETDEWEB)

    Corben, D.; Stevenson, R.; Wolstenholme, E.F. [Cognitus Ltd., Harrogate (United Kingdom)

    1999-07-01

    System dynamics has been seen primarily as a strategic tool, most effectively used at the highest level of strategy to identify robust policy interventions under a wide range of scenarios. However, an alternative, complementary and powerful role is emerging. This is at an &apos;intermediate level&apos; in organisations to coordinate and integrate policies across the value chain. It is at this level where business value, as defined by the discounted value of future free cash flow, is both created and destroyed. This paper introduces the need for &apos;intermediate-level&apos; and &apos;value-based&apos; modelling and emphasises the natural role of system dynamics in supporting a methodology to fulfil the need. It describes the development of an approach and its application in the oil industry to coordinate the response of people and tools within operational, financial and commercial functions across the value chain to address a variety of problems and issues. (author)

  17. Highly specific &apos;'sensing'&apos; of tryptophan by a luminescent europium(III) complex

    Energy Technology Data Exchange (ETDEWEB)

    Stubenrauch, Jan A.; Mevissen, Christian; Schulte, Marie F.; Bochenek, Steffen; Albrecht, Markus [RWTH Univ. Aachen (Germany). Inst. fuer Organische Chemie; Subramanian, Palani S. [Central Salt and Marine Chemicals, Research Institute (CSRI), Gujarat (India)

    2016-07-01

    The europium(III) complex 1-Cl{sub 3} (S,S-2,2{sup &apos;}-(((1,10-phenanthroline-2,9-diyl)bis(methanylylidene))bis (azanylyliden e))bis(3-methylbutanamide)europiumtrichloride) undergoes, only in the presence of the amino acid tryptophan, a change of emission at 615 nm. In the presence of few equivalents of tryptophan, emission of the europium complex is enhanced while it disappears upon addition of large amounts. This behavior can be assigned to displacement of the sensitizing phenanthroline ligand of 1-Cl{sub 2} x Trp in the latter case.

  18. ANALYZE Users&apos; Guide

    Energy Technology Data Exchange (ETDEWEB)

    Azevedo, S.

    1982-10-01

    This report is a reproduction of the visuals that were used in the ANALYZE Users&apos; Guide lectures of the videotaped LLNL Continuing Education Course CE2018-H, State Space Lectures. The course was given in Spring 1982 through the EE Department Education Office. Since ANALYZE is menu-driven, interactive, and has self-explanatory questions (sort of), these visuals and the two 50-minute videotapes are the only documentation which comes with the code. More information about the algorithms contained in ANALYZE can be obtained from the IEEE book on Programs for Digital Signal Processing.

  19. Tratamento farmacológico do tabagismo Pharmacological treatment of tobacco dependence

    Directory of Open Access Journals (Sweden)

    Guilherme Rubino de A. Focchi

    2005-10-01

    Full Text Available A cada ano, o tabagismo mata 5 milhões de pessoas em todo o mundo; este número tende a crescer nos próximos anos. A farmacoterapia tem grande importância no tratamento da dependência de nicotina. Este artigo faz uma revisão crítica dos principais tratamentos medicamentosos usados atualmente para o tratamento deste transtorno: a terapia de reposição de nicotina, a bupropiona e a nortriptilina.Each year, nicotine dependence kills five million people around the world and the morbidity and mortality due to tobacco use tends to increase in the following years. Pharmacotherapy has great importance in the treatment of nicotine dependence. This paper presents a critical review of the main pharmacotherapies presently available for the treatment of this disorder: nicotine replacement, bupropion and nortriptyline.

  20. Theory perspective: SCES &apos;05 Vienna

    Energy Technology Data Exchange (ETDEWEB)

    Coleman, P. [Center for Materials Theory, Rutgers University, Piscataway, NJ 08855 (United States)]. E-mail: coleman@physics.rutgers.edu

    2006-05-01

    Over the past decades, there has been research on strongly correlated electron materials that has consistently outperformed our wildest expectations, with new discoveries and radically new theoretical insights. SCES &apos;05 reaffirmed this vitality. Highlight areas included parity violating superconductivity, a new, two-dimensional helium-3 &apos;Kondo lattice&apos; and the discovery of quantum critical ferro-electricity. I review these and many other developments, with an emphasis on open questions and prospects for the future.

  1. Myonecrosis of Behcet&apos;s disease

    Energy Technology Data Exchange (ETDEWEB)

    Stubbs, Alana Y. [Southern Arizona Veterans Administration Health Care System, Department of Radiology, Tucson, AZ (United States); Taljanovic, Mihra S. [University of Arizona HSC, Radiology and Orthopaedic Surgery, Department of Radiology, Tucson, AZ (United States); Massey, Brandon Z. [The Village Offices, Institute for Plastic Surgery and Peripheral Nerve Surgery, Tucson, AZ (United States); Graham, Anna R. [University of Arizona HSC, Department of Pathology, Tucson, AZ (United States); Friend, Christopher J.; Walsh, Joshua A. [Inland Imaging, LLC, Spokane, WA (United States)

    2008-04-15

    Behcet&apos;s disease is an inflammatory disease of unknown cause characterized by intermittent episodes of acute inflammation manifested by oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. We report a rare case of myonecrosis associated with Behcet&apos;s disease. Myonecrosis of Behcet&apos;s disease can mimic soft tissue abscess and therefore awareness of this entity in the appropriate clinical setting is important for initiation of appropriate and timely treatment. (orig.)

  2. Custo-utilidade do tratamento do glaucoma primário de ângulo aberto no Brasil

    Directory of Open Access Journals (Sweden)

    Ricardo Augusto Paletta Guedes

    2016-02-01

    Full Text Available RESUMO Objetivo: Determinar a estratégia mais custo-efetiva para o tratamento do glaucoma primário de ângulo aberto em fase inicial, comparando-se as seguintes alternativas: observação, tratamento clínico ou tratamento com laser. Métodos: Por meio de um modelo de Markov, sob a perspectiva do Sistema Único de Saúde (SUS e um horizonte da expectativa de vida média da população brasileira. Comparou-se a razão de custo-utilidade incremental (ICUR entre 3 alternativas de tratamento, assim como seus custos e o ganho em qualidade de vida, medido em QALY (Quality-adjusted life years. Resultados: A ICUR do tratamento inicial com laser e do tratamento inicial com colírios, em relação a não tratar foi de R$ 2.811,39/QALY e R$ 3.450,47/QALY, respectivamente. Ambas as estratégias foram custo-efetivas, com uma discreta vantagem para o tratamento a laser. Esta diferença diminui ainda mais quando se aumenta a idade de entrada no modelo. As duas alternativas propiciaram ganhos significativos de qualidade de vida (em torno de 2,5 QALYs para o tratamento com laser e de 5,0 QALYs para o tratamento com colírios. Conclusão: Tanto o tratamento primário com trabeculoplastia a laser quanto com medicações foram custo-efetivos e proporcionaram ganhos reais de qualidade de vida quando comparados com o não tratamento do GPAA.

  3. Rosuvastatina e ciprofibrato no tratamento da dislipidemia em pacientes com HIV

    Directory of Open Access Journals (Sweden)

    Hamilton Domingos

    2012-11-01

    Full Text Available FUNDAMENTO: A dislipidemia secundária à terapia antirretroviral potente nos pacientes com HIV está associada à significativa elevação da morbimortalidade cardiovascular por doença aterosclerótica, sendo, portanto, necessário tratamento imediato e eficaz. OBJETIVO: Demonstrar a efetividade e a segurança da rosuvastatina e do ciprofibrato no tratamento da dislipidemia associada à terapia antirretroviral potente em pacientes com HIV. MÉTODOS: Trezentos e quarenta e seis pacientes com dislipidemia foram submetidos a tratamento farmacológico: 200 pacientes com hipertrigliceridemia receberam ciprofibrato (Grupo I; 79 pacientes com hipercolesterolemia receberam rosuvastatina (Grupo II; e 67 pacientes com dislipidemia mista receberam ciprofibrato associado a rosuvastatina (Grupo III. O perfil lipídico foi avaliado antes e após o tratamento hipolipemiante, sendo feita comparação estatística pelo teste de Wilcoxon. Transaminases hepáticas e creatinofosfoquinase foram dosadas para controle de toxicidade hepática e muscular. RESULTADOS: As concentrações séricas de triglicérides e de colesterol total foram significativamente menores do que as obtidas antes do tratamento, para os três grupos experimentais (p < 0,002. Observou-se aumento significativo do HDL colesterol nos grupos experimentais I e III (p < 0,002. Nos grupos I e II, o LDL-colesterol foi significativamente menor (p < 0,001. Nenhum dos pacientes apresentou elevações de transaminases ou de creatinofosfoquinase a níveis de toxicidade significativa. CONCLUSÃO: Os resultados deste estudo demonstram que ciprofibrato, rosuvastatina ou a combinação de ambos pode ser considerada tratamento hipolipemiante efetivo, seguro e com boa tolerância nos pacientes com Aids submetidos à terapia antirretroviral potente.

  4. Einstein-Rosen &apos;bridge&apos; needs lightlike brane source

    Energy Technology Data Exchange (ETDEWEB)

    Guendelman, Eduardo, E-mail: guendel@bgu.ac.i [Department of Physics, Ben-Gurion University of the Negev, PO Box 653, IL-84105 Beer-Sheva (Israel); Kaganovich, Alexander, E-mail: alexk@bgu.ac.i [Department of Physics, Ben-Gurion University of the Negev, PO Box 653, IL-84105 Beer-Sheva (Israel); Nissimov, Emil, E-mail: nissimov@inrne.bas.b [Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences, Boul. Tsarigradsko Chausee 72, BG-1784 Sofia (Bulgaria); Pacheva, Svetlana, E-mail: svetlana@inrne.bas.b [Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences, Boul. Tsarigradsko Chausee 72, BG-1784 Sofia (Bulgaria)

    2009-11-16

    The Einstein-Rosen &apos;bridge&apos; wormhole solution proposed in the classic paper (Einstein and Rosen (1935) ) does not satisfy the vacuum Einstein equations at the wormhole throat. We show that the fully consistent formulation of the original Einstein-Rosen &apos;bridge&apos; requires solving Einstein equations of bulk D=4 gravity coupled to a lightlike brane with a well-defined world-volume action. The non-vanishing contribution of Einstein-Rosen &apos;bridge&apos; solution to the right-hand side of Einstein equations at the throat matches precisely the surface stress-energy tensor of the lightlike brane which automatically occupies the throat (&apos;horizon straddling&apos;) - a feature triggered by the world-volume lightlike brane dynamics.

  5. &apos;Minergie&apos; on a large scale; Minergie im Grossformat

    Energy Technology Data Exchange (ETDEWEB)

    Hawkins, A. C.

    2007-07-01

    This article takes a look at two housing estates in the suburbs of Zurich, Switzerland, that conform to &apos;Minergie&apos; low energy-consumption standards. In contrast to single-family homes normally associated with the &apos;Minergie&apos; low energy-consumption label, here, two &apos;Minergie&apos; housing estates each with a number of apartment blocks are looked at. The systems for providing regulated fresh air with heat recovery are described. In one of the estates, heat is collected from a nearby sewer via heat-exchangers and, together with a heat-pump system, is used to heat the apartments. Nearby, in the other &apos;Minergie&apos; estate, a large, mains-connected photovoltaics plant is used to meet the net power requirements of a heat-pump-based heating system. In summer, power is sold to the local electricity utility.

  6. VDE/ITG position paper energy information networks and systems. Pt. A. &apos;&apos;Distribution grid automation in the smart grid&apos;&apos;; VDE/ITG-Positionspapier Energieinformationsnetze und -systeme. T. A. &apos;&apos;Verteilungsnetzautomatisierung im Smart Grid&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Huebner, Christian [ifak e.V., Magdeburg (Germany)

    2012-07-01

    The present paper reports results of the VDE / ITG focus group &apos;&apos;Energy Information Networks and Systems&apos;&apos; that published its second position paper in autumn 2012. The focus was on the issue of distribution automation, since the successful implementation of a smart energy system can be achieved only on the basis of a profound automation of distribution networks and other systems of energy supply interacting with them. With the participation of experts from the fields of energy supply, telecommunications, IT and automation technology, various aspects of distribution automation in the context of smart grid were analyzed and appropriate recommendations derived. The results are summarized in Part A &apos;&apos;Distribution Automation in Smart Grid&apos;&apos; of the position paper. (orig.)

  7. Those who &apos;Cry Wolf&apos; about nuclear safety damage their own credibility

    Energy Technology Data Exchange (ETDEWEB)

    Shepherd, John [nuclear 24, Redditch (United Kingdom)

    2016-06-15

    Do you recall the fable of the boy who cried wolf? I was reminded of this following the latest call by Germany&apos;s Federal Environment Minister, Barbara Hendricks, for Belgium to take two of its nuclear reactors off the grid, citing &apos;'questions'&apos; about the units&apos; safety. Those in positions of power and influence in one country should take care to be as responsible in their dealings with their neighbours as they are in handling domestic matters of state. Those who see &apos;danger&apos; where there is none are not being good neighbours. They are generating fear and alarm without good cause and should mind their own business.

  8. Atoms of helium in interstellar and interplanetary medium. 1. Observations of scattering ultraviolet radiation in lines of HI lambda 1216 A and HeI lambda 584 A by the &apos;&apos;Prognoz-5&apos;&apos; and &apos;&apos;Prognoz-6&apos;&apos; satellites

    Energy Technology Data Exchange (ETDEWEB)

    Burgin, M.S.; Kurt, V.G.; Mironova, E.N.; Prokhorenko, V.I.; Ehjsmont, N.A.; Berto, Zh.L.; Dalod' e, F.

    A review of observation results of the joint Soviet- French experiment on the measurement of scattering ultraviolet radiation in interplanetary medium in HIlambda1216 A and HeI 584 A hydrogen lines, is presented. The four-channel photometer Oas installed at two high-apogee satellites of &apos;&apos;Prognoz-5&apos;&apos; and &apos;&apos;Prognoz-6&apos;&apos;. The sky scanning was performed due to satellite rotation around its axis directed to the Sun. A vessel with hydrogen was set up in the HILsub(..cap alpha..) channel in order to measure the Lsub(..cap alpha..) line width. All parameters connected with the Sun motion in interplanetary medium were determined.

  9. Pythagoras&apos;s theorem on a two-dimensional lattice from a &apos;natural&apos; Dirac operator and Connes&apos;s distance formula

    Energy Technology Data Exchange (ETDEWEB)

    Dai Jian [Theory Group, Department of Physics, Peking University, Beijing (China)]. E-mail: jdai@mail.phy.pku.edu.cn; Song Xingchang [Theory Group, Department of Physics, Peking University, Beijing (China)]. E-mail: songxc@ibm320h.phy.pku.edu.cn

    2001-07-13

    One of the key ingredients of Connes&apos;s noncommutative geometry is a generalized Dirac operator which induces a metric (Connes&apos;s distance) on the pure state space. We generalize such a Dirac operator devised by Dimakis et al, whose Connes distance recovers the linear distance on an one-dimensional lattice, to the two-dimensional case. This Dirac operator has the local eigenvalue property and induces a Euclidean distance on this two-dimensional lattice, which is referred to as &apos;natural&apos;. This kind of Dirac operator can be easily generalized into any higher-dimensional lattices. (author)

  10. Hot air instead of electricity. Special modular pumps at &apos;&apos;Saunaparadies Erding&apos;&apos;; Heissluft statt Elektrowaerme. Modulare Sonderpumpen im Saunaparadies Erding

    Energy Technology Data Exchange (ETDEWEB)

    Christoph, D. [Grundfos GmbH, Erkrath (Germany)

    2008-07-01

    &apos;&apos;Saunaparadies Erding&apos;&apos; is a sauna spa with 16 newly constructed saunas and with an uncommon heating concept. The investor opted for hot air instead of electric heating. Accordingly, an industrial-scale boiler was installed in the mechanical equipment room. The boiler supplies air of 170 degC to the air-to-water heat exchangers in the sauna cabins. The design of this system was a great challenge to the planners and constructors and also to the components of the piping system. (orig.)

  11. O uso da terapia cognitivo-comportamental no tratamento do transtorno depressivo: uma abordagem em grupo

    Directory of Open Access Journals (Sweden)

    Terezinha Rech

    2010-01-01

    Full Text Available A depressão tem atingido amplos grupos sociais sem distinção entre eles e, constantemente, está associada como comorbidade a outras doenças. A Terapia Cognitivo- Comportamental (TCC começou a ser estruturada pelo psicanalista e psiquiatra Aaron Beck para oferecer tratamento a pessoas deprimidas. Foi aprimorada e chegou a propostas de tratamento em grupo desenvolvidas por Aaron Beck e demais colaboradores. Este estudo procura fazer uma breve revisão dos temas da TCC e de sua aplicação no tratamento em grupo para depressão, desde a sua formulação até a revisão do uso dessa terapia na atualidade. Foram analisados artigos do ano de 2008 dessa metodologia de trabalho e comparados com os cânones dessa tipologia de tratamento. A depressão tem atingido amplos grupos sociais sem distinção entre eles e, constantemente, está associada como comorbidade a outras doenças. A Terapia Cognitivo- Comportamental (TCC começou a ser estruturada pelo psicanalista e psiquiatra Aaron Beck para oferecer tratamento a pessoas deprimidas. Foi aprimorada e chegou a propostas de tratamento em grupo desenvolvidas por Aaron Beck e demais colaboradores. Este estudo procura fazer uma breve revisão dos temas da TCC e de sua aplicação no tratamento em grupo para depressão, desde a sua formulação até a revisão do uso dessa terapia na atualidade. Foram analisados artigos do ano de 2008 dessa metodologia de trabalho e comparados com os cânones dessa tipologia de tratamento. Abstract Depression affects a variety of social groups without distinction, and usually occurs as comorbidity with other disorders. The Cognitive Behavioral Therapy (CBT was originally structured by Aaron Beck to provide treatment to depressed people. It was later improved by him and his collaborators and developed into a proposal of group therapy. This study comprises a brief review of CBT topics and their application in group therapy of depression, from its formulation to its

  12. DUODENOPLASTIA ASSOCIADA À VAGOTOMIA GÁSTRICA PROXIMAL NO TRATAMENTO DAS ÚLCERAS DUODENAIS ESTENOSANTES

    OpenAIRE

    Ceneviva R.; Santos J. S. dos; Silva Jr. O. de C.; Módena J. L. P.; Mente E. D.; Sankarankutty A. K.

    2001-01-01

    A vagotomia gástrica proximal firmou-se como o procedimento de escolha no tratamento cirúrgico eletivo das úlceras duodenais crônicas, por ser a operação mais segura quanto à morbidade e mortalidade. Sua aplicação tem sido estendida às complicações da úlcera duodenal, mediante operação complementar que visa solucionar a complicação. Com o objetivo de avaliar a vagotomia gástrica proximal no tratamento das úlceras duodenais estenosantes os resultados clínicos de uma série consecutiva de 80 pac...

  13. Tratamento de parasitoses intestinais pela associação piperazina-tiabendazol

    Directory of Open Access Journals (Sweden)

    Adelina S. Velho Soli

    1972-08-01

    Full Text Available Os autores apresentam os resultados obtidos com o emprego da associação antihelmintica piperazina-tiabendazol no tratamento de infecção por Ascaris lumbricoides e ancilostomídeos. Considerando a cura de 81 % dos casos de ascaridíase e de 80% dos casos de ancilostomíase, bem como a ótima tolerância ao medicamento, acreditam que esta associação medicamentosa possa ser empregada com sucesso para o tratamento das referidas parasitoses.

  14. Anemia ferropênica no adulto: causas, diagnóstico e tratamento

    OpenAIRE

    Cançado,Rodolfo D.; Carlos S. Chiattone

    2010-01-01

    A deficiência de ferro, especificamente a anemia ferropênica, permanece como uma das deficiências nutricionais mais frequentes e importantes no mundo. Este artigo revisa as principais causas de anemia ferropênica, os atuais métodos de investigação diagnóstica e as estratégias de prevenção. O tratamento com ferro deve ser iniciado sempre por via oral, e a investigação apropriada de sua causa é obrigatória; quando houver falha nesse tratamento por causa de grande perda de sangue, má absorção do...

  15. Cistos de bolsa de Rathke: diagnóstico e tratamento

    Directory of Open Access Journals (Sweden)

    Rodrigues Flávio Freinkel

    2001-01-01

    Full Text Available Estudamos retrospectivamente quatro pacientes com cisto de bolsa de Rathke. Chamamos a atenção para a apresentação clínica e para o tratamento destas lesões. Todos ocorreram em pacientes do sexo feminino. Os sintomas predominantes foram amenorréia, cefaléia e déficit visual. Revisamos várias séries publicadas de cistos de bolsa de Rathke. Concluimos que o tratamento cirúrgico é ainda a melhor conduta e que a via transesfenoidal é a abordagem mais indicada.

  16. Tratamento farmacológico de transtornos alimentares Pharmacological treatment of eating disorders

    Directory of Open Access Journals (Sweden)

    Fábio Tapia Salzano

    2004-01-01

    Full Text Available Os autores revisaram a literatura a respeito do tratamento farmacológico para transtornos alimentares, incluindo anorexia nervosa, bulimia nervosa e transtorno da compulsão alimentar periódica. São apresentadas evidências clínicas relacionadas ao uso de psicofármacos nos transtornos alimentares e apontadas, ainda, as perspectivas futuras para o tratamento.The authors have revised the literature about the pharmacological treatment of eating disorders, including anorexia nervosa, bulimia nervosa and binge-eating disorder. Clinical evidences of the medications action in eating disorders are presented, and future perspectives for the treatment are indicated.

  17. The development and treatment of impulsivity = O desenvolvimento e tratamento da impulsividade

    OpenAIRE

    Amorim Neto, Roque do Carmo; True, Mary

    2011-01-01

    Impulsividade é um fator presente em várias desordens psicológicas, incluindo ADHD, drogadição, comportamentos agressivos e automutiladores, e obesidade infantil. Impulsividade também é um fator de risco para o abandono de tratamento. Este artigo tem por objetivo apresentar as raízes da impulsividade do ponto de vista biológico, sociológico e do desenvolvimento humano, bem como as formas de tratamento mais comuns para pessoas com extrema impulsividade. Aqui também se inclui pesquisas das área...

  18. Adesão ao tratamento da tuberculose: Aspectos da vulnerabilidade individual e social

    OpenAIRE

    2015-01-01

    Elementos de vulnerabilidade individual e social podem interferir na adesão ao tratamento da tuberculose (TB), contextualizados no ambiente o qual o doente está inserido. Os marcadores de adesão, por sua vez, detectam precocemente vulnerabilidades na adesão ao tratamento de doentes com TB, por meio de escores, apresentando forte potencialidade para o monitoramento dessa adesão no âmbito da Atenção Primária à Saúde (APS), aprimorando a vigilância de pessoas com TB. OBJETIVO: Ver...

  19. The development and treatment of impulsivity = O desenvolvimento e tratamento da impulsividade

    Directory of Open Access Journals (Sweden)

    Amorim Neto, Roque do Carmo

    2011-01-01

    Full Text Available Impulsividade é um fator presente em várias desordens psicológicas, incluindo ADHD, drogadição, comportamentos agressivos e automutiladores, e obesidade infantil. Impulsividade também é um fator de risco para o abandono de tratamento. Este artigo tem por objetivo apresentar as raízes da impulsividade do ponto de vista biológico, sociológico e do desenvolvimento humano, bem como as formas de tratamento mais comuns para pessoas com extrema impulsividade. Aqui também se inclui pesquisas das áreas de desenvolvimento neuronal e regulação emocional

  20. Tratamento de efluentes de carcinicultura por macrófitas aquáticas flutuantes

    OpenAIRE

    Henry-Silva,Gustavo Gonzaga; Camargo,Antonio Fernando Monteiro

    2008-01-01

    Avaliou-se neste estudo a eficiência de sistemas compostos de duas espécies de macrófitas aquáticas flutuantes (Eichhornia crassipes e Pistia stratiotes) no tratamento de efluentes gerados por um viveiro de manutenção de reprodutores de camarões-canela (Macrobrachium amazonicum). Os sistemas de tratamento foram constituídos de 12 unidades experimentais com as macrófitas aquáticas e três sem plantas (controle). Foram analisadas amostras da água de abastecimento do viveiro de criação de camarõe...

  1. Tratamento cirúrgico da laringomalácia grave: estudo retrospectivo de 11 casos

    OpenAIRE

    2013-01-01

    A laringomalácia é a anomalia congênita da laringe mais frequente, sendo responsável por cerca de 60% a 75% dos casos de estridor congênito. Apesar de seu curso benigno e autolimitado, 10% dos casos necessitam de intervenção. Atualmente, as supraglotoplastias são consideradas o tratamento padrão da laringomalácia grave. OBJETIVO: Descrever a experiência adquirida pelos autores no tratamento cirúrgico dos pacientes com laringomalá...

  2. Contributions to the qualification of the &apos;'CRISTAL'&apos; criticality calculi scheme: interpretation of critical experiments. Elaboration of a characterization system of neutronic configurations; Contributions a la qualification du schema de calcul de criticite &apos;'cristal'&apos;: interpretation d&apos;experiences critiques. Elaboration d&apos;un systeme de caracterisation des configurations neutroniques

    Energy Technology Data Exchange (ETDEWEB)

    Gagnier, E

    1999-06-01

    This thesis work is about the validation of the new criticality-safety package CRISTAL and contributes to the modernization and the improvement of the computational tools. The first part presents neutronic elements, the objectives of safety criticality studies and the package CRISTAL. Then, the validation work concerned two series of experiments involving uranyl solutions (UO{sub 2}F{sub 2}) and UO{sub 2} powders. For these experiments, the differences between the computation results and the experimental results were analysed. It was highlighted interesting physical phenomena such of the compensations of errors between the approximate representation by the 99 energy group structure on the first resonance of oxygen and the anisotropy of the diffusion simulation as well as the influence of uranium 234 in high enriched solutions in uranium 235. Once the work of the experimental qualification carried out, raises the question of the use the base of qualification and the &apos;'calculation-experiment'&apos; variations which are referred to it. It is often difficult to establish the link between the &apos;&apos;studied configuration&apos;&apos; and the experiments of the base of qualification. The presented characterisation system proposes to answer in a way automatic and quantified this difficulty: - in bringing an answer on the package qualification for the studied configuration, - in giving an estimate of the package bias. To answer these points, it was defined a set of 35 characteristic neutronic parameters representing the behaviour of the medium. To process the information brought by these parameters and to use it to answer the objectives of the system, we called upon statistical methods (Principal Components Analysis and Sliced Inverse Regression). The results obtained in the feasibility studies showed the relevance of these methods for the considered objectives. (author)

  3. Report of study group 4.1 &apos;&apos;pipeline ageing and rehabilitation&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Serena, L.

    2000-07-01

    This report describes the work on the subject &apos;pipeline ageing and rehabilitation&apos; carried out by the Study Group 4.1 and related to the triennium 1997 - 2000. The report is focused on ageing and rehabilitation of natural gas transmission pipelines and more in detail on the following topics: - Definition of pipeline ageing; - Different ageing elements; - Main causes of ageing; - Inspections and monitoring; - Repair methods on ageing pipelines; - Programmes and strategies for pipeline maintenance and rehabilitation. The report includes the state of the art of the different techniques used to assess pipeline ageing such as pig inspection, landslide areas monitoring as well as advanced monitoring methods used nowadays by pipeline operators; a clarification of the concepts for different maintenance approaches is also presented. In addition the report gives some information regarding repair methods in use, the methodologies to evaluate the defects and the philosophy on which each repair system is based. The remaining topics deal with the strategies of pipelines and coating rehabilitation, locus the attention in the economical and technical considerations also beyond the ageing concept and describe in details the main causes of ageing as indicated by operators. A questionnaire on these topics was in fact distributed and the obtained results are included in this report. (author)

  4. Why Was Kelvin&apos;s Estimate of the Earth&apos;s Age Wrong?

    Science.gov (United States)

    Lovatt, Ian; Syed, M. Qasim

    2014-01-01

    This is a companion to our previous paper in which we give a published example, based primarily on Perry&apos;s work, of a graph of ln "y" versus "t" when "y" is an exponential function of "t". This work led us to the idea that Lord Kelvin&apos;s (William Thomson&apos;s) estimate of the Earth&apos;s age was…

  5. Critical Pedagogy&apos;s Problem with Changing Teachers&apos; Dispositions towards Critical Teaching

    Science.gov (United States)

    Neumann, Jacob W.

    2013-01-01

    Increasing teachers&apos; dispositions towards critical teaching is a fundamental goal for critical pedagogy. Because critical educational change cannot occur without teachers&apos; "buy-in," developing teachers&apos; inclination to implement critical teaching into their classrooms is a prerequisite for any successful critical pedagogy…

  6. Individual Differences in Children&apos;s and Parents&apos; Generic Language

    Science.gov (United States)

    Gelman, Susan A.; Ware, Elizabeth A.; Kleinberg, Felicia; Manczak, Erika M.; Stilwell, Sarah M.

    2014-01-01

    Generics ("&apos;Dogs&apos; bark") convey important information about categories and facilitate children&apos;s learning. Two studies with parents and their 2- or 4-year-old children (N = 104 dyads) examined whether individual differences in generic language use are as follows: (a) stable over time, contexts, and domains, and (b) linked…

  7. BREF Information Sheet on &apos;&apos;Waste Treatment&apos;&apos;. Significance of European plant standards for mechanical biological waste treatment plants; BREF-Merkblatt &apos;'Abfallbehandlung'&apos;. Bedeutung europaeischer Anlagenstandards fuer die mechanisch-biologische Abfallbehandlung

    Energy Technology Data Exchange (ETDEWEB)

    Kalmbach, S. [Umweltbundesamt Dessau (Germany)

    2006-07-01

    The IVU Directive of the European Union of 1996 requires that all environmentally relevant industrial plants, this including waste disposal plants, must be equipped with the &apos;&apos;best available techniques&apos;&apos; (BAT). By 30 October 2007 at the latest this is also to apply for all existing plants. The pan-European exchange of information on best available techniques will be facilitated by Best Available Technique Reference (BREF) Notes as provided by the Sevilla Process. The present paper explains the significance of these documents for the member states and their use in Germany. It gives an overview of BREF work already completed or in progress. The author describes the &apos;&apos;Sevilla Process&apos;&apos; and the most important harmonisation outcomes for the BREF Note on &apos;&apos;Waste Treatment&apos;&apos;, which comprises chemical and physical treatment, mechanical biological treatment, preparation of refuse-derived fuels, slag processing, solvent recycling, and used oil recycling. He concludes with an outlook on the implementation of the BREF Notes.

  8. Teaching Laura Kipnis&apos;s "Love&apos;s Labors" in "Ways of Reading"

    Science.gov (United States)

    Fike, Matthew A.

    2013-01-01

    This essay describes a method of teaching a very challenging anthology piece: Laura Kipnis&apos;s "Love&apos;s Labors" (chapter 1 of her 2003 "Against Love: A Polemic"). The method, although designed for a critical thinking course, should also provide resources for those who teach Kipnis&apos;s work in writing courses. Using…

  9. Fossil sources: &apos;running out&apos; is not the problem

    Energy Technology Data Exchange (ETDEWEB)

    Scott, D.S. [University of Victoria, BC (Canada). Institute for Integrated Energy System

    2005-01-01

    In which we discuss reserves, resources and the mythology that, sooner or later, our fossil sources will be gone. Then, to help appreciate the real reason fossil reserves will ultimately vanish, we evoke Weary Willie&apos;s clown routine &apos;sweeping up the spotlight.&apos; (author)

  10. The Impact of Adolescents&apos; Dyslexia on Parents&apos; and Their Own Educational Expectations

    Science.gov (United States)

    Rimkute, Laura; Torppa, Minna; Eklund, Kenneth; Nurmi, Jari-Erik; Lyytinen, Heikki

    2014-01-01

    The present study examined the role that adolescents&apos; dyslexia plays in their educational expectations, as well as their parents&apos; expectations concerning their offspring&apos;s future education. To investigate this, 170 adolescents were asked to report their educational expectations on two occasions while they were still attending…

  11. Agreements for energy and environment; Patto per l&apos;energia e l&apos;ambiente

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-07-01

    In this paper are reported in ambit of italian national conference of energy and environment, an agreement undersigned by deputy of political and social forces. [Italian] In questo documento e&apos; illustrato il patto per l&apos;energia e l&apos;ambiente cui hanno aderito forze sociali e politiche del paese.

  12. Primary Health Care Providers&apos; Knowledge Gaps on Parkinson&apos;s Disease

    Science.gov (United States)

    Thompson, Megan R.; Stone, Ramona F.; Ochs, V. Dan; Litvan, Irene

    2013-01-01

    In order to determine primary health care providers&apos; (PCPs) knowledge gaps on Parkinson&apos;s disease, data were collected before and after a one-hour continuing medical education (CME) lecture on early Parkinson&apos;s disease recognition and treatment from a sample of 104 PCPs participating at an annual meeting. The main outcome measure…

  13. James Baldwin&apos;s "Everybody&apos;s Protest Novel": Educating Our Responses to Racism

    Science.gov (United States)

    Frank, Jeff

    2014-01-01

    The aim of this article is to establish--and explore--James Baldwin&apos;s significance for educational theory. Through a close reading of "Everybody&apos;s Protest Novel", I show that Baldwin&apos;s thinking is an important (if unrecognized) precursor to the work of Stanley Cavell and Cora Diamond, and is relevant to a number of…

  14. On the Relations between Parents&apos; Ideals and Children&apos;s Autonomy

    Science.gov (United States)

    de Ruyter, Doret J.; Schinkel, Anders

    2013-01-01

    In this article Doret J. de Ruyter and Anders Schinkel argue that parents&apos; ideals can enhance children&apos;s autonomy, but that they may also have a detrimental effect on the development of children&apos;s autonomy. After describing the concept of "ideals" and elucidating a systems theoretical conception of autonomy, de Ruyter and…

  15. The energy and monetary implications of the &apos;24/7 &apos;always on&apos; society

    Energy Technology Data Exchange (ETDEWEB)

    Loveday, Dennis L. [Department of Civil and Building Engineering, Loughborough University, Loughborough, Leicestershire LE11 3TU (United Kingdom); Bhamra, T.; Tang, T. [Department of Design and Technology, Loughborough University, Loughborough, Leicestershire LE11 3TU (United Kingdom); Haines, V.J.A. [Ergonomics and Safety Research Institute (ESRI), Loughborough University, Loughborough, Leicestershire LE11 3TU (United Kingdom); Holmes, M.J. [ARUP, 13, Fitzroy Street, London W1T 4BR (United Kingdom); Green, R.J. [Institute for Energy Research and Policy, University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom)

    2008-12-15

    This paper reviews the trends in society, technology and energy demand of the past 30 years, together with the growth of the &apos;on-demand&apos; culture. The &apos;24/7&apos; or &apos;always on&apos; society can be defined as one where people demand - and generally receive - what they want &apos;now&apos;. It has grown up in parallel with developments in information technology, which have produced the services needed to meet that demand. Larger numbers of appliances, resulting from greater affluence and disposable income, have increased energy use, despite energy efficiencies in other areas. While monetary factors suggest that changes brought about by the 24/7 society will generally be self-correcting at the macro-economic level, there will nevertheless be effects for individuals, such as potentially severe impacts on the fuel poor as electricity prices rise. We conclude with a view of future directions. As the 24/7 culture continues to grow, there is scope for designers and for information technology to manage and reduce energy consumption. This includes buildings, their services systems, and the mix of new technologies that will be deployed over the next 20 years or so, including the possibilities for data exchange and control at the interface between energy suppliers and consumers, coupled with greater understanding of the behaviour of the consumers themselves. (author)

  16. Resting-state functional connectivity changes in aging apoE4 and apoE-KO mice

    NARCIS (Netherlands)

    Zerbi, V.; Wiesmann, M.; Emmerzaal, T.L.; Jansen, D.; Beek, M. van; Mutsaers, M.P.C.; Beckmann, C.F.; Heerschap, A.; Kiliaan, A.J.

    2014-01-01

    It is well established that the cholesterol-transporter apolipoprotein epsilon (APOE) genotype is associated with the risk of developing neuro-degenerative diseases. Recently, brain functional connectivity (FC) in apoE-epsilon 4 carriers has been investigated by means of resting-state fMRI, showing

  17. Resting-state functional connectivity changes in aging apoE4 and apoE-KO mice

    NARCIS (Netherlands)

    Zerbi, V.; Wiesmann, M.; Emmerzaal, T.L.; Jansen, D.; Beek, M. van; Mutsaers, M.P.; Beckmann, C.F.; Heerschap, A.; Kiliaan, A.J.

    2014-01-01

    It is well established that the cholesterol-transporter apolipoprotein epsilon (APOE) genotype is associated with the risk of developing neurodegenerative diseases. Recently, brain functional connectivity (FC) in apoE-epsilon4 carriers has been investigated by means of resting-state fMRI, showing a

  18. Reduction of NO{sub x} emissions from the combustion of hard coals &apos;'RENOX'&apos;; Reduccion de Emisiones de NO{sub x} en la combustion de Carbones Antracitosos &apos;'RENOX'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    The present project, whose abbreviated name is RENOX, has the aim of reducing NO{sub x} emissions from the combustion of hard coals or coals with low volatile matter contents. It is applied to the combustion of these coals in arc boilers (or &apos;'U'&apos; boilers), where the necessary combination of long presence times and high hearth temperatures facilitates the high NO{sub x} levels reached. The intended reduction in emissions is approached through the application of primary combustion measures, also known as adjustment or refining of combustion. This solution is adopted for two reasons: due to its efficiency in environmental and economic terms, and because it is an unavoidable step if the levels to be attained require the installation of specific gas crubbing systems (secondary measures). The practical nature of RENOX has led to the development of the project in two phases, corresponding to two logical stages: phase 1, associated with the RNA project, on the characterization of emissions and combustion, complex numeric modelling of flows inside the boiler, and determination of the viability and scope of the optimization of emissions, and phase 2, the OPTINOXproject, which follows the methodology and lessons of the first phase and, as a natural continuation of this, deals with the design, development, manufacturing and validation of a computerized system that processes real time data on the boiler where it is installed to monitor, supervise and control the commercial operation of the plant, optimizing its combustion efficiency and/or NO{sub x} emissions. The practical objective of this project is represented by the construction of a validated prototype to demonstrate the OPTINOX system, which is capable of determining operating and control strategies that can minimize NO{sub x} emissions without unfavourably affecting the productivity and specific consumption of the units. Phase 1 development activities took place in groups 3, 4 and 5 of Compostilla

  19. SKI&apos;s and SSI&apos;s review of SKB&apos;s safety report SR-Can

    Energy Technology Data Exchange (ETDEWEB)

    Dverstorp, Bjoern; Stroemberg, Bo (and others)

    2008-03-15

    This report summarises SKI&apos;s and SSI&apos;s joint review of the Swedish Nuclear Fuel and Waste Management Co&apos;s (SKB) safety report SR-Can (SKB TR-06-09). SR-Can is the first assessment of post-closure safety for a KBS-3 spent nuclear fuel repository at the candidate sites Forsmark and Laxemar, respectively. The analysis builds on data from the initial stage of SKB&apos;s surface-based site investigations and on data from full-scale manufacturing and testing of buffer and copper canisters. SR-Can can be regarded as a preliminary version of the safety report that will be required in connection with SKB&apos;s planned licence application for a final repository in late 2009. The main purpose of the authorities&apos; review is to provide feedback to SKB on their safety reporting as part of the pre-licensing consultation process. However, SR-Can is not part of the formal licensing process. In support of the authorities&apos; review three international peer review teams were set up to make independent reviews of SR-Can from three perspectives, namely integration of site data, representation of the engineered barriers and safety assessment methodology, respectively. Further, several external experts and consultants have been engaged to review detailed technical and scientific issues in SR-Can. The municipalities of Oesthammar and Oskarshamn where SKB is conducting site investigations, as well NGOs involved in SKB&apos;s programme, have been invited to provide their views on SR-Can as input to the authorities&apos; review. Finally, the authorities themselves, and with the help of consultants, have used independent models to reproduce part of SKB&apos;s calculations and to make complementary calculations. All supporting review documents are published in SKI&apos;s and SSI&apos;s report series. The main findings of the review are: -SKB&apos;s safety assessment methodology is overall in accordance with applicable regulations, but part of the methodology needs to be

  20. Workshop &apos;&apos;actual data processing supported applications in the area of soil protection and contaminated sites&apos;&apos;; Workshop &apos;&apos;Aktuelle DV-gestuetzte Anwendungen im Bodenschutz- und Altlastenbereich&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Mathews, Jeannette; Frauenstein, Joerg; Mahrle, Sabine (comps.)

    2011-05-15

    Within the 5th workshop at the Federal Environment Agency (Dessau-Rosslau, Federal Republic of Germany) from 28th to 29th September, 2010, the following lectures were held: (1) Information systems for the contaminated site management in Baden-Wuerttemberg (I. Blankenhorn); (2) SALKA 7 - A web based solution for a central data handling of the Saxonian register of contaminated sites (S. Gruhne); (3) Information system (ABuDIS) for contaminated sites, soil conservation and disposal sites in the Free State of Bavaria - Experiences from the project &apos;Data quality&apos; (O. Klammer); (4) Environmental specimen bank - Web interface (M. Ruether); (5) Biocides in the Web - A portal for the publicity (G. Minx); (6) INSPIRE - Thematic work group (TWG) Appendix III Soil (S. Marahrens); (6) INSPIRE - State of the art, requirements (R. Baritz); (7) Requirements for the interoperability of soil data from the view of the Federal Environment Agency (F. Hilliges); (8) Implementation of the PortalU-Software in the European context - The project GS Soil (K. Feiden); (9) What is offered by PRTR - Pollutant Release and Transfer Register? (E. Six); (10) GSBL - Application for web recherche (B. Liebscher); (11) New Web Map Service for ground water background values (B. Wagner); (12) Visualized information on contaminated sites - A status (J. Frauenstein); (13) Utilization of industrial wastelands - An idea makes soil good. A project of BAFU for revitalization of industrial wastelands (K. Schenk); (14) Information on the status of ground water for the governmental real estates (H.-O. Zintz); (15) Application of data processing procedures of the artificial intelligence on an area-based representation of pollutant contents in settlement areas (T. Hertwig).

  1. Development of sodium boiling model, &apos;SOBOIL&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Won Pyo; Hahn, Do Hee

    2002-01-01

    The objective of this research is to develop an algorithm for the sodium boiling modeling, essential to the KALIMER HCDA Analysis. The basic theory is based on the &apos;Muti-slug Ejection Model&apos; in SAS2A. It allows a finite number of bubbles in a channel at any time, and a formed bubble fills the whole cross section of the coolant channel except for liquid film left on the cladding surface. The essence of the model is to estimate the bubble pressure and temperature by balancing the bubble state change with the energy transfer into the bubble at both the wall and interfaces. It assumes that the bubble is saturated with a uniform pressure and temperature, and a bubble is generated when the coolant temperature exceeds a specified superheat. The period of the algorithm development has been divided into two phases. The algorithm development and application during the first phase is limited to the active fuel region where relatively simple physical phenomena are anticipated under ULOHS accident conditions in KALIMER, because it is favorable to the verification of the basic algorithm. The main revision is made during the 2nd phase to take into account mass transfer between the liquid film and bubble, bubble collapse, and coalescence as a liquid slug diminishes. In conclusion, the model represents the anticipated physical phenomena reasonably. The bubble has grown rapidly in consistence with the previous model predictions. Instability, however, is found in the wall heat transfer because the bubble size exceeds a certain value, over which the homogeneous model is no longer valid. Therefore, the model is expected to be improved by taking account of the pressure drop due to vapor flow inside such a large bubble to extend its applicability.

  2. &apos;Whole new envelope&apos; ahead in technology

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2000-10-16

    To improve efficiency and to increase profits the oil industry will leave no stone unturned in its quest for the latest in technological development. The most recent venture is in the field of biotechnology; it involves an attempt to harness a newly-discovered variety of bacteria to improve oil sands production. It is the objective of the newly created NSERC-Syncrude Chair in Oil Sands Research, established recently at the University of Alberta with grants totalling $3.5 million. The plan is not only to push the envelope, but to develop an a whole new envelope to turn black bitumen into gold crude oil by going beyond the currently limited uses of biotechnology in environmental cleanups to incorporate bacteria into the production process. The centre of attention is the Pseudomonas bacteria that consumes nitrogen, a common impurity in crude oil, and converti it into ammonia. The result is that at least theoretically, the bacteria can replace high pressure hydrogenation, the costly process used by refineries. The process appears to work in the laboratory but industrial scale trials are still to come. Research of the planned intensive effort will be published and available to the entire industry; it will be up to industry and refineries to develop proprietary applications of the new knowledge. The fundamental research work is expected to take about five years, but other items on the agenda, such as improvements to &apos;coking&apos; to reduce solid wastes and increase the liquid yield of the initial phases of oil sands production are expected to be available much sooner. Development of catalysts to improve the quality and volume of final synthetic oil output is also one of the research objective of this newly endowed chair.

  3. 3&apos;,5&apos;-diiodothyronine in health and disease: studies by a radioimmunoassay

    Energy Technology Data Exchange (ETDEWEB)

    Chopra, I.J.; Geola, F.; Solomon, D.H.; Maciel, R.M.B.

    1978-12-01

    An RIA has been developed for 3&apos;5&apos;-diiiodothyronine (3&apos;,5&apos;-T/sub 2/) in unextracted serum. Interference in binding of radioactive 3&apos;,5&apos;-T/sub 2/ to anti-3&apos;,5&apos;-T/sub 2/ was minimized by using phosphate buffer and merthiolate. The detection threshold of the RIA was 2.5 ng/dl. Recovery of nonradioactive 3&apos;,5&apos;-T/sub 2/ averaged 99%. T/sub 4/, T/sub 3/, and rT/sub 3/ cross-reacted with anti-3&apos;,5&apos;-T/sub 2/ antibody 0.0025, < 0.0004, and 0.22%, respectively. The 3&apos;-monoiodothyronine cross-reacted 1.7%. Mean serum 3&apos;,5&apos;-T/sub 2/ concentrations in ng/dl were 2.4 in 53 normal subjects, 4.2 in 7 hypothyroid patients, 14.9 in 34 hyperthyroid patients, 13.5 in 25 patients with hepatic cirrhosis, and 14.3 in 31 newborns&apos; cord blood serum. The values for the latter four groups were significantly different from normal. The serum 3&apos;,5&apos;-T/sub 2/ concentration of 7.7 ng/dl in eight subjects in the third trimester of pregnancy did not differ from normal when serum T/sub 4/ and T/sub 3/ were elevated. Oral administration of 300 ..mu..g rT/sub 3/ to 9 normal subjects led to an increase in serum 3&apos;5&apos;-T/sub 2/ concentration of 45% at 1h. Total fasting in 3 obese subjects was associated with an increase in serum 3&apos;,5&apos;-T/sub 2/ from 8.6 to 16.3 ng/dl at 6 to 8 days; rT/sub 3/ increased similarly, while T/sub 3/ decreased and T/sub 4/ did not change. Administration of dexamethasone to 4 hyperthyroid patients was associated with nearly parallel increases in serum 3&apos;,5&apos;-T/sub 2/ and rT/sub 3/ and a decrease in T/sub 3/. The 3&apos;,5&apos;-T/sub 2/ concentrations in amniotic fluids were 15.2 ng/dl at 15 to 20 weeks gestation and 5.8 ng/dl at 33 to 40 weeks. Pronase hydrolysates of 9 normal thyroid glands contained 350 ..mu..gT/sub 4/ and 0.24 ..mu..g 3&apos;,5&apos;-T/sub 2//g wet wt. It was estimated that thyroidal secretion contributes < 1% of 3&apos;,5&apos;-T/sub 2/ in

  4. Green economy. From theory to practice; &apos;Green Economy&apos;. Von der Theorie zur Praxis

    Energy Technology Data Exchange (ETDEWEB)

    Wackerbauer, Johann [ifo Institut, Muenchen (Germany)

    2013-04-15

    The topic of &apos;&apos;green economy&apos;&apos; took centre stage at last year&apos;s UN conference on sustainable development in Rio de Janeiro. The term &apos;&apos;green economy&apos;&apos; has many interpretations to it, ranging from an emphasis on energy and resource efficiency in an otherwise ordinary economy to positions that are critical of growth as such. What can be considered as the essence of the concept of green economy, and what challenges need to be mastered on the way there? The present study shows that there is more to the term than most companies and consumers are aware of.

  5. Comment on &apos;Finding viscosity of liquids from Brownian motion at students&apos; laboratory&apos; and &apos;Brownian motion using video capture&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Greczylo, Tomasz; Debowska, Ewa [Institute of Experimental Physics, Wroclaw University, pl. Maxa Borna 9, 50-204 Wroclaw (Poland)

    2007-09-15

    The authors make comments and remarks on the papers by Salmon et al (2002 Eur. J. Phys. 23 249-53) and their own (2005 Eur. J. Phys. 26 827-33) concerning Brownian motion in two-dimensional space. New, corrected results of calculations and measurements for students&apos; experiments on finding the viscosity of liquids from Brownian motion are presented. (letters and comments)

  6. Apolipoprotein E (ApoE) polymorphism is related to differences in potential fertility in women: a case of antagonistic pleiotropy?

    Science.gov (United States)

    Jasienska, Grazyna; Ellison, Peter T; Galbarczyk, Andrzej; Jasienski, Michal; Kalemba-Drozdz, Malgorzata; Kapiszewska, Maria; Nenko, Ilona; Thune, Inger; Ziomkiewicz, Anna

    2015-03-22

    The alleles that are detrimental to health, especially in older age, are thought to persist in populations because they also confer some benefits for individuals (through antagonistic pleiotropy). The ApoE4 allele at the ApoE locus, encoding apolipoprotein E (ApoE), significantly increases risk of poor health, and yet it is present in many populations at relatively high frequencies. Why has it not been replaced by natural selection with the health-beneficial ApoE3 allele? ApoE is a major supplier of cholesterol precursor for the production of ovarian oestrogen and progesterone, thus ApoE has been suggested as the potential candidate gene that may cause variation in reproductive performance. Our results support this hypothesis showing that in 117 regularly menstruating women those with genotypes with at least one ApoE4 allele had significantly higher levels of mean luteal progesterone (144.21 pmol l(-1)) than women with genotypes without ApoE4 (120.49 pmol l(-1)), which indicates higher potential fertility. The hormonal profiles were based on daily data for entire menstrual cycles. We suggest that the finding of higher progesterone in women with ApoE4 allele could provide first strong evidence for an evolutionary mechanism of maintaining the ancestral and health-worsening ApoE4 allele in human populations.

  7. India&apos;s Higher Education Challenges

    Science.gov (United States)

    Altbach, Philip G.

    2014-01-01

    India, with the world&apos;s second largest higher education system and a rapidly growing economy as one of the BRIC nations, faces significant challenges in building both capacity and excellence in higher education. India&apos;s higher education system is characterized by "islands of excellence in a sea of mediocrity." The mainstream…

  8. Poland&apos;s syndrome: radiologic findings

    Energy Technology Data Exchange (ETDEWEB)

    Bazzi Junior, Joao Lourenco, E-mail: joaobazzijr@gmail.com [Clinica Via Imagem, Xanxere, SC (Brazil); Matta, Eduardo Simoes da [Pro Circulacao - Clinica de Angiologia, Cirurgia Vascular e Ecografia Vascular, Xanxere, SC (Brazil); De Bortoli, Luciano [Materclinica Materno Infantil, Xanxere, SC (Brazil); De Bortoli, Felipe Raasch [Universidade Catolica de Pelotas (UCPel), Pelotas, RS (Brazil). Fac. of Medicine

    2012-05-15

    Poland&apos;s syndrome is a rare non-inherited congenital anomaly. The authors describe the classic radiologic findings of Poland&apos;s syndrome by reporting the case of a male four-year old patient with asymmetry of hands and chest, illustrating the fundamental imaging criteria for a conclusive diagnosis. (author)

  9. Omani Students&apos; Definitions of Geography

    Science.gov (United States)

    Al-Nofli, Mohammed Abdullah

    2014-01-01

    Very few studies have been conducted on students&apos; definitions of geography. The purpose of the present study was to add to the existing literature by exploring Omani students&apos; definitions of geography. Participants were 477 students of grade 6 (ages 11-12) and grade 10 (ages 15-16) in one school district in Oman. They had been taught…

  10. Final Report, NERI Project: &apos;&apos;An Innovative Reactor Analysis Methodology Based on a Quasidiffusion Nodal Core Model&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Dmitriy Y. Anistratov; Marvin L. Adams; Todd S. Palmer; Kord S. Smith; Kevin Clarno; Hikaru Hiruta; Razvan Nes

    2003-08-04

    OAK (B204) Final Report, NERI Project: &apos;&apos;An Innovative Reactor Analysis Methodology Based on a Quasidiffusion Nodal Core Model&apos;&apos; The present generation of reactor analysis methods uses few-group nodal diffusion approximations to calculate full-core eigenvalues and power distributions. The cross sections, diffusion coefficients, and discontinuity factors (collectively called &apos;&apos;group constants&apos;&apos;) in the nodal diffusion equations are parameterized as functions of many variables, ranging from the obvious (temperature, boron concentration, etc.) to the more obscure (spectral index, moderator temperature history, etc.). These group constants, and their variations as functions of the many variables, are calculated by assembly-level transport codes. The current methodology has two main weaknesses that this project addressed. The first weakness is the diffusion approximation in the full-core calculation; this can be significantly inaccurate at interfaces between different assemblies. This project used the nodal diffusion framework to implement nodal quasidiffusion equations, which can capture transport effects to an arbitrary degree of accuracy. The second weakness is in the parameterization of the group constants; current models do not always perform well, especially at interfaces between unlike assemblies. The project developed a theoretical foundation for parameterization and homogenization models and used that theory to devise improved models. The new models were extended to tabulate information that the nodal quasidiffusion equations can use to capture transport effects in full-core calculations.

  11. Universal machine &apos;'Shtrek'&apos; and the tractor-lifter with pneumatic-equipment control. [Auxiliary multipurpose materials handling equipment

    Energy Technology Data Exchange (ETDEWEB)

    Bal' bert, B.M.; Borumenskiy, V.A.; Lishenko, A.P.; Mitchenko, G.A.

    1982-01-01

    The machine &apos;'Shtrek'&apos; is described. It makes it possible to mechanize over 20 auxiliary operations: loading-unloading operations: extraction of old and deformed timbering; dissmantling of obstructions; erection of different types of timbering; making and restoring of drainage channels; laying and straightening of a drift and its leveling; assembly and disassembly of pipelines and mine equipment, etc. Depending on the type of operation, the machine has the corresponding suspended equipment. The elementary variant has a limited area of application at mines of the central region of the Dunbass. Currently a pneumatic variant of the machine &apos;'Shtrek'&apos; has been developed. The electric motor and the starter of the pumping equipment of the machine have been replaced by a pneumatic motor and pneumatically controlled valve KTM-50. In this case there was significant reduction in the weight of the pumping equipment and in its overall dimensions; the electric drive of the hydraulic distributors for controlling the mechanisms were replaced by simpler pneumatic ones; the logical circuit of the control system was constructed on the USEPPA elements. A specialized tractor-lifter designed for moving suspended loads is described for auxiliary operations in the near-face zone of the preparatory drifts. The machine also lifts and lowers the boom, rotates the boom by 270/sup 0/ and additionally lifts and lowers the weight-lifting hook.

  12. New EPA &apos;PLUS&apos; software: A useful tool for local emergency planners

    Energy Technology Data Exchange (ETDEWEB)

    Anastas, P.T.; Tobin, P.S.

    1993-09-01

    EPA&apos;s Office of Pollution Prevention and Toxics has produced a new bibliographic database designed for local emergency planners. The PLUS&apos;&apos; (Planner&apos;s Library in User-friendly Software) system is a resource database containing abstracts of hundreds of references useful in planning for hazardous substances emergencies. The software&apos;s structure allows planners to construct customized search strategies for generating lists of emergency planning-related references on subjects ranging from chemical profiles to personal protective gear.

  13. Intensidade do Tratamento e Qualidade de Vida Relacionada com a Saúde no Cancro Pediátrico

    Directory of Open Access Journals (Sweden)

    Susana Santos

    2014-11-01

    Full Text Available ObjetivoEste estudo teve como objetivos apresentar a versão portuguesa da Escala de Classificação da Intensidade do Tratamento 3.0, uma medida objetiva para avaliar a intensidade do tratamento no cancro pediátrico, e comparar a qualidade de vida relacionada com a saúde (QdVrS em crianças/adolescentes com diferentes níveis de intensidade do tratamento.MétodoA amostra foi constituída por 129 crianças/adolescentes com cancro (98 em tratamento e 31 fora de tratamento. A intensidade do tratamento foi classificada pelos médicos oncologistas pediátricos com a Escala de Classificação da Intensidade do Tratamento 3.0 e a QdVrS foi avaliada pelas crianças/adolescentes através do DISABKIDS Chronic Generic Measure (DCGM-12.ResultadosAs análises do coeficiente de Kappa revelaram excelentes índices de fiabilidade interavaliadores. Verificou-se a existência de diferenças estatisticamente significativas na QdVrS de acordo com o nível de intensidade do tratamento. Comparações post-hoc revelaram níveis de QdVrS superiores em crianças/adolescentes com tratamentos de intensidade 2 comparativamente aos de intensidade 3 e 4.ConclusãoOs dados evidenciam a importância de intervenções para melhorar a QdVrS junto de potenciais grupos de risco, definidas de acordo com a intensidade do tratamento.

  14. &apos;Micromorph&apos; solar cells; &apos;Mikromorphe&apos; Solarzellen, basierend auf amorphem und mikrokristallinem Silizium

    Energy Technology Data Exchange (ETDEWEB)

    Shah, A.

    2000-07-01

    This report on behalf of the Swiss Federal Office of Energy (SFOE) describes the achievements made in a project carried out at the Institute of Microelectronics (IMT) in Neuchatel, Switzerland. The project, whose goal was to demonstrate the potential of tandem cells consisting of a combination of micro-crystalline and amorphous solar cells, has spawned world-wide interest and also initiated much research into the use of VHF-GD (Very High Frequency Glow-discharge) techniques to deposit thin films. Individual results achieved at IMT including those from investigations into micro-crystalline structures and textures and their absorption enhancement effects, electronic transport, improvement of open-circuit voltage, deposition rates, patterning techniques and increasing stabilised efficiencies are listed. A first Micromorph 23.6 cm{sup 2} mini-module using an integrated electric series connection concept is mentioned and advances in the IMT&apos;s infrastructure and facilities are described.

  15. Tratamento da espasticidade: uma atualização Treatment of spasticity: an update

    Directory of Open Access Journals (Sweden)

    HÉLIO A.G. TEIVE

    1998-12-01

    Full Text Available Apresentamos revisão sobre o tratamento atual da espasticidade, enfocando a terapêutica farmacológica, fisioterápica e através da utilização de toxina botulínica.We present an update about the treatment of spasticity, stressing the pharmacological treatment, physical therapy and botulinum toxin therapy.

  16. Abscesso intracerebral: tratamento clínico. Experiência com um caso

    Directory of Open Access Journals (Sweden)

    José Carlos Lynch

    1985-12-01

    Full Text Available É relatado o caso de um paciente com abscesso intracerebral que foi tratado com êxito de forma clínica. A literatura pertinente é revista e os autores concluem que a forma conservadora de tratamento pode ser utilizada em casos selecionados de abscesso cerebral.

  17. Representações sociais das pessoas com tuberculose sobre o abandono do tratamento

    Directory of Open Access Journals (Sweden)

    Narda Estela Calsin Chirinos

    Full Text Available RESUMO Objetivo Compreender as representações sociais das pessoas com tuberculose sobre o abandono do tratamento em um Programa de Controle da Tuberculose. Método Estudo descritivo, de abordagem qualitativa, realizado num município de Lima, Peru. Os dados foram coletados de outubro a novembro de 2012, através de entrevistas semiestruturadas, com oito pessoas, e analisados conforme a técnica de análise temática de conteúdo. Resultados As categorias levaram à construção da representação social de que a doença e o tratamento trazem sofrimento. Esta representação influencia na não adesão ao tratamento, podendo gerar um incremento de casos de abandono. Conclusão São necessárias estratégias educativas ligadas a processos de interação social, à subjetividade e ao contexto do paciente, direcionadas a diminuir o abandono do tratamento da tuberculose, as recidivas, a multirresistência. Novos desafios são apontados diante das avaliações frente ao alcance dos Objetivos de Desenvolvimento do Milênio.

  18. COMPOSIÇÃO DE CULTIVARES DE SOJA SUBMETIDA A DIFERENTES TRATAMENTOS TÉRMICOS

    Directory of Open Access Journals (Sweden)

    N. C. MOURA

    2008-11-01

    Full Text Available

    A composição centesimal e a presença de fitatos e inibidores de tripsina foram avaliadas nas cultivares de soja Embrapa 48, BRS 212, BRS 214 e BRS 231 submetidas a diferentes tratamentos térmicos (cocção em panela aberta, panela de pressão, microondas e autoclave. Os dados obtidos permitiram a elaboração de rótulo nutricional para os grãos submetidos ao tratamento em panela de pressão. A cocção por microondas preservou a porcentagem de carboidratos e diminuiu o teor de proteínas nas cultivares, com exceção da cultivar BRS 231. Os tratamentos em autoclave e panela de pressão foram os mais eficientes para reduzir os fitatos. O tratamento por microondas foi eficiente para reduzir os inibidores de tripsina em duas cultivares (BRS 212 e BRS 214.

  19. História dos tratamentos biológicos Biologicals treatments's history

    Directory of Open Access Journals (Sweden)

    Sérgio Paulo Rigonatti

    2004-01-01

    Full Text Available Contexto: Trata-se de uma discussão de como surgiram os tratamentos biológicos no decorrer da história da psiquiatria.Context: It's about a discussion on how begun the biological treatment throughout Psychiatry History.

  20. Tratamento da bulimia nervosa: síntese das evidências

    Directory of Open Access Journals (Sweden)

    Bacaltchuk Josué

    1999-01-01

    Full Text Available As duas abordagens terapêuticas mais estudadas para o tratamento da bulimia nervosa (BN são os tratamentos psicológicos, principalmente a terapia cognitivo-comportamental (TCC e o uso de antidepressivos. Os resultados de duas revisões sistemáticas da literatura mostram que a TCC é melhor que fila de espera e que os antidepressivos são superiores ao placebo na remissão a curto prazo dos sintomas bulímicos. A comparação direta das duas abordagens mostra que, quando usados como abordagens exclusivas, a TCC é clinicamente mais eficaz e mais aceita do que os antidepressivos. A associação dos dois tipos de tratamento é clinicamente mais eficaz que cada um isoladamente, mas a aceitação das abordagens psicológicas exclusivas é maior. Como a BN é um transtorno grave e com baixa taxa de remissão espontânea, o tratamento associado, com abordagem multidimensional e multidisciplinar, pode ser indicado.

  1. Exercícios para tratamento de lombalgia inespecífica

    Directory of Open Access Journals (Sweden)

    Daniele Tatiane Lizier

    2012-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A lombalgia é uma síndrome frequente e provoca incapacidade e perda no trabalho. Apesar de existirem diversas causas, o tipo de lombalgia mais frequente é a inespecífica. Os exercícios são frequentemente empregados para o tratamento da lombalgia porém existem controvérsias quanto a sua eficácia. O objetivo deste texto foi fazer uma revisão sobre exercícios para tratamento de lombalgia inespecífica. CONTEÚDO: Foram descritas a definição e a classificação das lombalgias. A incidência e os mecanismos da lombalgia inespecífica, e os exercícios empregados para seu tratamento foram relatados. CONCLUSÕES: Os tipos de exercícios terapêuticos para lombalgia crônica ou aguda que são mais eficazes, ainda são bastante controversos, contudo exercícios terapêuticos são provavelmente o tratamento conservativo mais usado no mundo todo.

  2. Supplemental report on cost estimates&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-04-29

    The Office of Management and Budget (OMB) and the U.S. Army Corps of Engineers have completed an analysis of the Department of Energy&apos;s (DOE) Fiscal Year (FY) 1993 budget request for its Environmental Restoration and Waste Management (ERWM) program. The results were presented to an interagency review group (IAG) of senior-Administration officials for their consideration in the budget process. This analysis included evaluations of the underlying legal requirements and cost estimates on which the ERWM budget request was based. The major conclusions are contained in a separate report entitled, &apos;&apos;Interagency Review of the Department of Energy Environmental Restoration and Waste Management Program.&apos;&apos; This Corps supplemental report provides greater detail on the cost analysis.

  3. Europe&apos;s New Energy Policy

    Energy Technology Data Exchange (ETDEWEB)

    Piebalgs, A. [Directorate-General for Energy, European Commission, Brussels (Belgium); Conn, I. [British Petroleum BP, London (United Kingdom); Dobbeni, D. [Elia, Brussels (Belgium); Josefsson, L.G. [Vattenfall, Stockholm (Sweden); Mogg, L. [ERGEG-CEER, Brussels (Belgium); Rifkin, J. [Foundation on Economic Trends, Bethesda, MD (United States); Scaroni, P. [Eni, Rome (Italy); Tanaka, N. [International Energy Agency IEA, Paris (France)

    2009-01-15

    Europe&apos;s energy policy has been completely transformed over the last few years, tackling the dual challenges of climate change and energy security. This has lead to major new laws on issues such as energy liberalisation, renewable energy and energy efficiency. In this volume the detailed reasons for these changes are outlined and the way in which the European Union has risen to these challenges is discussed. Views are given on where Europe&apos;s energy policy will go next, the challenges of 2050 and the development of a &apos;third industrial revolution&apos;. This insight is complemented by the observations and comments of some of the leading figures concerning European and global energy issues, explaining how industry, energy regulators and global thinkers see Europe&apos;s energy policy and the challenges that it now faces.

  4. Technical and quality requisites (RTC&apos;s) &apos;a data architecture&apos;; Requisitos tecnicos y de calidad (RTC&apos; s) &apos;una arquitectura de datos&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Munoz G, R.; Jimenez R, B.; Ahedo A, S. [ININ, 52750 La Marquesa, Estado de Mexico (Mexico)]. e-mail: rmg@nuclear.inin.mx

    2007-07-01

    The RTC&apos;s are notes of technical and of quality requisites that the CLV emits, according to validity procedures of the Nuclear power station, to specify purchasing requisites of equipment with quality assurance category. This document contains a description of the computer program application RTC&apos;s, elaborated by the ININ for the CLV that allows to capture and to process the information of a database whose purpose is to facilitate the elaboration of the RTC&apos;s. Details of its development process are included. (Author)

  5. Gastos publicos com medicamentos para o tratamento da osteoporose na pos-menopausa

    Directory of Open Access Journals (Sweden)

    Cristina Mariano Ruas Brandao

    2013-06-01

    Full Text Available OBJETIVO: Analisar os gastos com medicamentos para o tratamento da osteoporose na pós-menopausa e os fatores associados ao gasto médio per capita . MÉTODOS: Pareamento probabilístico-determinístico a partir das bases das Autorizações de Procedimentos de Alta Complexidade com o Sistema de Informação sobre Mortalidade, resultando em coorte histórica de pacientes que utilizaram medicamentos de alto custo para o tratamento da osteoporose na pós-menopausa de 2000 a 2006. O gasto médio mensal com medicamentos foi estratificado por faixas etárias e descrito de acordo com as características demográficas, clínicas e tipo de medicamento utilizado. Foi utilizado modelo de regressão linear para avaliar o impacto de características demográficas e clínicas sobre o gasto médio mensal per capita com os medicamentos. RESULTADOS: Foram identificadas 72.265 mulheres que receberam medicamentos para o tratamento da osteoporose na pós-menopausa. O gasto médio mensal per capita no primeiro ano de tratamento foi de R$ 90,00 (dp R$ 144,49. A maioria das mulheres tinha de 60 a 69 anos de idade, iniciaram tratamento em 2000, eram residentes na região Sudeste, tinham fraturas osteoporóticas prévias e o alendronato de sódio foi o medicamento mais utilizado no início do tratamento. A maioria das pacientes permaneceu em uso do mesmo princípio ativo durante o tratamento. Foram identificados 6.429 óbitos entre as participantes. Mais de um terço das mulheres permaneceram no programa por até 12 meses. Raloxifeno e calcitonina sintética foram as alternativas com maior impacto sobre o gasto médio mensal com medicamentos, tendo como padrão de referência o alendronato de sódio. CONCLUSÕES: Dado o alto impacto do tipo de medicamento utilizado no gasto com medicação, recomenda-se estabelecer critérios para prescrição e dispensação, com prioridade para aqueles com menores custos e maior efetividade. Isso pode otimizar o processo de assist

  6. May Goedel&apos;s Ideas Be Addressed Philosophically?

    Energy Technology Data Exchange (ETDEWEB)

    Dokulil, Milos [Department of Information Technologies, Faculty of Informatics, Masaryk University, Botanicka 68a, 602 00 Brno (Czech Republic)

    2007-11-15

    Goedel emphasised philosophy as an important tool in science. Much less is known about his religious background. We should bear in mind that our evaluational perspective differs very much from the one in which Goedel lived. He was personally sure that there must be another existence after death-an afterlife (&apos;of unlimited life span&apos;). As a &apos;Baptized Lutheran&apos; he did not include &apos;Trinity&apos; in his creed. He was also certain that mind is separate from matter. This text tries to include Libet&apos;s &apos;readiness potential&apos; into the debate concerning the specificity of the mind. Neither Goedel&apos;s identification of materialism with mechanism nor his vision of the &apos;spirit&apos; are a viable solution of the problem.

  7. Measure of the e+e-{yields}bb Cross Section at the LEP Energies; Medida de la seccion eficaz e&apos;'+e'&apos;-{yields}bb a las Energias de LEP

    Energy Technology Data Exchange (ETDEWEB)

    Arce Dubois, P.

    1992-07-01

    In the present work I analyse the data collected during 1990 by the L3 detector, situated in the electron-positron collider LEP. After selecting the events e&apos;'+e'&apos;-{yields} bb through their semileptonic decays into muons, I calculate the cross section for the process e&apos;'+e'&apos;- {yields} bb at different energy points around the mass of the vectorial boson Z, and I measure some parameters of the Standard Model, namely, the Br(b{yields}{mu} ),{gamma}{sub z}n-{yields}bb/{gamma}{sub z}n{yields}had and {gamma}{sub z}n{yields}bb{gamma}{sub z}n{yields}e&apos;'+e'&apos;-. (Author) 26 refs.

  8. Short circuit - How our power supply became more expensive and got worse. A critical balance after eight years &apos;'deregulation'&apos; of the German Energy Economy; Kurzschluss - Wie unsere Stromversorgung teurer und schlechter wurde. Eine kritische Bilanz nach acht Jahren &apos;'Liberalisierung'&apos; der deutschen Energiewirtschaft

    Energy Technology Data Exchange (ETDEWEB)

    Leuschner, U.

    2007-07-01

    Since 16 years the author, a journalist, pursues the economical and political development of the German power economy. Many facts of this book prove: the impacting consequences as the clear scarcity of 1998 introduced deregulation, which has permitted 8 years long the discrimination of competitors and enabled in this way an exampleless concentration of market might (pt. 1); how supply reliability became worse and power and gas got more and more expensive (pt. 2); the complete insufficient practice of cartel agreements which is exchanged by administrative grid charges respectively &apos;&apos;incentive regulation&apos;&apos; (pt. 3); the relation between management and policy which has become still more distantless than in the epoche of membership books (pt. 4); the development of the German power economy from the beginning in the 19th century to the deregulation incl. the reorganization on the area of the former German Democratic republic. (GL) [German] Im ersten Teil des Buches (&apos;&apos;Stromwirtschaft im Umbruch&apos;&apos;) befasst sich Leuschner nun noch eingehender mit den politischen Hintergruenden der verfehlten Deregulierung. Er stellt fest, dass es die letzte Regierung unter Helmut Kohl war, die von Anfang an die Weichen falsch gestellt hat. Die Hauptverantwortung fuer die Nichtkorrektur des Fehlers und den fortgesetzten &apos;&apos;Schmusekurs mit den Konzernen&apos;&apos; sieht er aber bei den beiden folgenden rot-gruenen Bundesregierungen. Er verdeutlicht ferner, dass die erhoehten Belastungen durch Stromsteuer, EEG und KWK-Gesetz keine hinreichende Begruendung fuer den Strompreisanstieg liefern. Wo nicht minder wichtige Faktoren fuer den Preisanstieg liegen, veranschaulicht er im Kapitel ueber die &apos;&apos;Preisveredelung an der EEX&apos;&apos;. Im zweiten Teil, der die technischen Hintergruende und Risiken der Deregulierung behandelt, findet man jetzt auch ausfuehrlich die europaweite Netzstoerung beschrieben, die EON am 4. November 2006

  9. Fair Miles? The concept of &apos;food miles&apos; through a sustainable development lens

    Energy Technology Data Exchange (ETDEWEB)

    MacGregor, James; Vorley, Bill

    2006-10-15

    The concept of &apos;food miles&apos; presents an argument to buy goods which have travelled the shortest distance from farm to table, and to discriminate against long-haul transportation, especially air-freighted goods. The long-distance transport of food is associated with additional emissions due to increased transportation coupled with greater packaging, as well as a disconnection between the public and local farming. Furthermore, &apos;food miles&apos; encapsulates (and is at the vanguard of) the climate change debate in the UK. In light of growing international concern over the speed and scale of climate change, the concept of &apos;food miles&apos; has captured public attention and apparently is changing some consumers&apos; behaviour, although only around one-third of shoppers know of the concept.

  10. Gene-Environment Interplay in the Link of Friends&apos; and Nonfriends&apos; Behaviors with Children&apos;s Social Reticence in a Competitive Situation

    Science.gov (United States)

    Guimond, Fanny-Alexandra; Brendgen, Mara; Vitaro, Frank; Forget-Dubois, Nadine; Dionne, Ginette; Tremblay, Richard E.; Boivin, Michel

    2014-01-01

    This study used a genetically informed design to assess the effects of friends&apos; and nonfriends&apos; reticent and dominant behaviors on children&apos;s observed social reticence in a competitive situation. Potential gene-environment correlations (rGE) and gene-environment interactions (GxE) in the link between (a) friends&apos; and…

  11. The Influence of Teachers&apos; Conceptions on Their Students&apos; Learning: Children&apos;s Understanding of Sheet Music

    Science.gov (United States)

    López-Íñiguez, Guadalupe; Pozo, Juan Ignacio

    2014-01-01

    Background: Despite increasing interest in teachers&apos; and students&apos; conceptions of learning and teaching, and how they influence their practice, there are few studies testing the influence of teachers&apos; conceptions on their students&apos; learning. Aims: This study tests how teaching conception (TC; with a distinction between…

  12. Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein

    Directory of Open Access Journals (Sweden)

    Ioannis Papaioannou

    2012-01-01

    Full Text Available Cardiovascular disease is the leading worldwide cause of death. Apolipoprotein E (ApoE is a 34-kDa circulating glycoprotein, secreted by the liver and macrophages with pleiotropic antiatherogenic functions and hence a candidate to treat hypercholesterolaemia and atherosclerosis. Here, we describe atheroprotective properties of ApoE, though also potential proatherogenic actions, and the prevalence of dysfunctional isoforms, outline conventional gene transfer strategies, and then focus on gene correction therapeutics that can repair defective APOE alleles. In particular, we discuss the possibility and potential benefit of applying in combination two technical advances to repair aberrant APOE genes: (i an engineered endonuclease to introduce a double-strand break (DSB in exon 4, which contains the common, but dysfunctional, ε2 and ε4 alleles; (ii an efficient and selectable template for homologous recombination (HR repair, namely, an adeno-associated viral (AAV vector, which harbours wild-type APOE sequence. This technology is applicable ex vivo, for example to target haematopoietic or induced pluripotent stem cells, and also for in vivo hepatic gene targeting. It is to be hoped that such emerging technology will eventually translate to patient therapy to reduce CVD risk.

  13. Lack of association of apoE ε4 allele with insulin resistance.

    Science.gov (United States)

    Ragogna, Francesca; Lattuada, Guido; Ruotolo, Giacomo; Luzi, Livio; Perseghin, Gianluca

    2012-02-01

    ApoE is a polymorphic protein involved in the metabolism of plasma lipoproteins; the ε4 allele was shown to be associated with coronary and aortic atherosclerosis in age-dependent fashion mediated by unknown mechanisms. This study was undertaken to assess whether the apoE isoforms in humans were associated with normal glucose tolerance and with metabolic and inflammatory risk factors of CVD. ApoE genotype was assessed in 365 individuals. Of those, 309 were studied in the postabsorptive conditions and 142 of them also underwent a 3h-OGTT; 56 additional subjects were studied by means of the insulin clamp in combination with [6,6-2H2] glucose infusion. ApoE genotype frequencies were similar to those previously reported and were not influenced by age and BMI. Fasting plasma glucose, insulin, FFA, the lipid profile, surrogate markers (HOMA-IR, OGTT-derived index) as well as the clamp-derived parameters or insulin sensitivity and insulin secretion were not different by apoE genotypes. Serum adipokines concentrations (leptin, adiponectin, resistin) and markers of inflammation (serum fasting hsCRP and MCP1/CCL2) were also not different by apoE genotypes. In the subgroup of young ε4 carriers which underwent the clamp procedure, a higher fasting endogenous glucose production was detected. ApoE genotype was not associated with insulin resistance or altered insulin secretion, and no abnormalities in the typical circulating endocrine, metabolic, and inflammatory features of the insulin resistance syndrome were detected.

  14. &apos;Early&apos; thyroid [sup 123]I uptake: correction for extrathyroidal neck radioactivity

    Energy Technology Data Exchange (ETDEWEB)

    Arntzenius, A.B.; Meinders, A.E. (University Hospital, Leiden (Netherlands). Dept. of Internal Medicine); Heide, D. van der (Agricultural Univ., Wageningen (Netherlands). Dept. of Human and Animal Physiology)

    1992-11-01

    Should one correct for extrathyroidal neck radioactivity (&apos;&apos;neck background&apos;&apos;) when interpreting perchlorate discharge test results A new background correction method was developed using a linear probe. [sup 123]I produces photon peaks at two energy levels: 159 keV ([gamma]-rays) and 28 keV (X-rays), with an attenuation of 15 and 35% per cm water, respectively. If one fixes the position of the subject&apos;s neck, radiation from thyroid [sup 123]I produces an X/[gamma] detection ratio ([alpha]) which is constant and, due to the anterior localization of the thyroid, higher than the ratio ([beta]) produced by extrathyroidal [sup 123]I. These two ratios can be determined in vivo and used to calculate background-corrected and depth-corrected thyroid uptake. In simulation experiments our method was effective so long as the &apos;'gland'&apos; was situated close enough to the &apos;'neck'&apos; surface for the difference ([alpha]-[beta]) to be less than 0.19. Perchlorate discharge tests were performed in five euthyroid subjects who were pretreated with methimazole. The difference ([alpha]-[beta]) ranged from 0.27 to 0.36. Uncorrected, the mean discharge was 57% (range 47-66); corrected, it was 92% (range 88-94). In 15 hyperthyroid Graves&apos; patients, with goitres varying from 13 to 63 ml, [alpha]-[beta] ranged from 0.22 to 0.40 and was unrelated to goitre size. The contribution of neck background is quantitatively important, especially when thyroid uptake is low; our new method corrects for it, even with large goitres. (Author).

  15. Germany steps up pressure on Fessenheim, but is the &apos;Energiewende&apos; all-knowing?

    Energy Technology Data Exchange (ETDEWEB)

    Shepherd, John [nuclear 24, Brighton (United Kingdom)

    2015-04-15

    Politics of course has more than its fair share of those who know everything and do their best not to let get the facts get in the way where inconvenient truths risk destroying their &apos;'Besserwisser'&apos; illusions. An example of this is a letter from Germany&apos;s federal environment minister Barbara Hendricks to her French counterpart Segolene Royal. The subject of the letter was the closure of France&apos;s Fessenheim nuclear power plant. The content of the letter appears to show that, not content with stamping out the use of nuclear energy in Germany and all the knowledge and industrial expertise that goes with it, Germany seems intent on imposing its point of view onto its neighbour. Hendricks acknowledges that any decisions relating to Fessenheim are for France alone as a sovereign nation. But, if that is the case, why bother to write the letter in the first place? In reply Royal, a prominent French Socialist, stresses French president Francois Hollande&apos;s desire to close Fessenheim before his term of office draws to a close. Royal also noted that it is up to France&apos;s nuclear operator, EDF, to &apos;&apos;define which reactors are removed from the grid&apos;&apos;. It is also amusing to read Royal&apos;s comment that the fact Fessenheim can be closed at all is largely due to the construction of replacement nuclear capacity at Flamanville, in northern France. Surely that irony could not have been lost on Germany&apos;s environment ministry.

  16. Eletroacupuntura para tratamento de hipotensão induzida por isofluorano em cavalos

    Directory of Open Access Journals (Sweden)

    E.C. Franco

    2014-04-01

    Full Text Available Objetivou-se avaliar a eficiência do tratamento da hipotensão arterial com eletroacupuntura comparativamente à dobutamina em equinos. Foram avaliados seis cavalos adultos, saudáveis, mantidos em anestesia inalatória, com isofluorano, em ventilação mecânica. Após a estabilização da anestesia, foi induzida hipotensão arterial, através do incremento da concentração do isofluorano, iniciando-se um dos tratamentos: DOB: dobutamina (1,5µg kg-1 min-1, infusão contínua intravenosa; EA: estímulo elétrico no acuponto pericárdio 6 (PC6, bilateralmente; SHAM: estímulo elétrico em ponto falso de acupuntura. Foram mensurados: frequência cardíaca (FC, pressão arterial média (PAM, temperatura retal (T, concentração final expirada de isofluorano (ETiso, variáveis hemogasométricas, concentração sérica de aspartato aminotransferase (AST e creatina fosfoquinase (CK, tempo e qualidade da recuperação pós-anestésica. Houve incremento na PAM de 50%, 36,6% e 7,5% nos tratamentos DOB, EA e SHAM, respectivamente. Não houve diferença entre os grupos nas variáveis hemogasométricas, FC, T, ETiso, CK, AST, tempo e qualidade de recuperação pós-anestésica. Conclui-se que o tratamento com dobutamina foi mais efetivo para o tratamento da hipotensão em cavalos sob anestesia inalatória quando comparado ao estímulo elétrico do acuponto PC6 ou ponto falso de acupuntura.

  17. Comparative analysis of the tools &apos;Retrofit Advisor&apos; and &apos;EPIQR+&apos; - Final report; Analisi comparativa degli strumenti &apos;Retrofit Advisor&apos; e &apos;EPIQR+&apos; - Rapporto finale

    Energy Technology Data Exchange (ETDEWEB)

    Pittet, D.; Ghirlanda, L.

    2008-07-01

    This report represents the final phase of Swiss Federal Office of Energy project &apos;Strategy for long-term management of city-owned real estate - the case of the City Council of Chiasso&apos;. It contains a comparative analysis of two tools for the evaluation of the potential for retrofitting and refurbishment of buildings (Retrofit Advisor and Epiqr+). By applying the two tools in parallel, it was possible to compare information and data obtained, and also to obtain indications for the evaluation of the usability of the tools. To achieve this, five buildings in the territory of the city of Chiasso were submitted to the tools for analysis. The applications have highlighted the usability of each case study. The ease of use of Retrofit Advisor has allowed the evaluation of each proposed scenario; by using the same reference system, comparable data are obtained (at indication level) to support the choice of the intervention strategy on existing buildings. In addition to the analysis of the current status, the tool Retrofit Advisor supports a structure analysis over three intervention scenarios, namely reparation, renovation, rebuild. Data entry does not require advanced knowledge of construction work, and is limited to basic characteristics. The analysis performed through Epiqr+ is more rigorous, providing a specific and detailed diagnosis on the state of deterioration of each construction element, supported by a series of intervention suggestions. The Epiqr+ tool has furthermore allowed the evaluation (within a precision range of {+-}15%) the cost of reparation/renovation works, and also the thermal energy balance of each building, based on the characteristics of their envelops. On the basis of contents criteria and cost analysis, the approach has allowed the evaluation of different options for the improvement of the buildings, from simple reparation to total rebuild. Estimates are evaluated in terms of cost, of environmental impact, and, in the case of Retrofit

  18. Report of working committee 10 &apos;&apos;gas and developing / transitional economy countries&apos;&apos;; Rapport du comite de travail 10 &apos;&apos;pays gaziers en voie de developpement et en transition economique&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Hached, A.

    2000-07-01

    This report deals with the works undertaken by working committee 10 during the 1997 - 2000 Triennium. The objective set by the IGU consisted in studying the generic thema in gas markets development for the less developed countries, in the developing countries with intermediate revenue as well as in the transitional economy countries. The first study group devoted his works to the problematic analysis of natural gas in the less developed countries, those where the GNP per capita is very low and the internal markets of which are little or non dynamic. This analysis has been developed in a certain number of countries rather representative of their respective region: Angola, Cameroon and Cote d&apos;Ivoire for sub-Saharian Africa, Bangladesh and Vietnam for Asia. The second study group analysed the changes in transitional economy countries (Baltic, countries in Central Europe and Ukraine) and their different consequences on gas industry. These countries apply gas industry reforms which are not implemented at the same rate more especially as they belong to a huge and very contrasted geographic region. The third study group devoted his works to the analysis of intensified conditions in the use of natural gas in the developing countries with intermediate revenue. He also examined the feasibility of an economic development in gas distribution networks in large cities. Two important issues focused his attention: financing and technology transfer. (author)

  19. Woc 5 distribution. Report of study group 5.1 &apos;&apos;service pipes&apos;&apos;; Rapport du groupe de travail 5.1 &apos;'branchements'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Sircar, A.; Hec, D.

    2000-07-01

    Service pipes are constitute an important link in the gas distribution chain. By their numbers, their relative weakness against third party aggressions and due to the fact that they constitute in most cases the limit of responsibility between the gas company network and customers&apos; installations, service pipes have been identified as a technical and economical key issue for the gas industry development. This document analyses technical and economical data dealing with domestic service pipes having a maximum flow rate of 10 m3/h collected from 42 gas companies spread over 22 countries. All service pipes elements, from the connection with the distribution network up to the delivery point, are analysed emphasizing their layouts and design, the materials used, the construction techniques, the operating and maintenance policies and a few rehabilitation techniques. The main different technical solutions given by the gas companies have been compared in order for the study group to draw up some recommendations regarding the best practices in terms of safety, ease of maintenance and economical savings. (author)

  20. Solar campaign &apos;Solar - na klar.&apos; (solar - of course). Final report; Solarkampagne &apos;Solar - na klar.&apos;. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Gege, M.; Kleinsteuber, A.; Krabbe, P.; Kroeger, P.; Maschke, K.; Niedert, S.; Schindelmann, F.; Thunert, A.; Weinberg, H.

    2002-03-18

    The German market for technically matured solar-thermal systems for generating hot water is growing by 20 per cent per year, with some deviations due to incentive policies. This growth can be and is planned to be increased systematically, with following goals: A practical contribution to the Federal Government&apos;s efforts to achieve the goals regarding the protection of climate; creating future-oriented jobs; supporting ecologically sustainable ways of life and models of consumption by convincing the consumers and other target groups of the fact that it makes sense already today to start utilizing solar energy and to invest also on private basis. These targets are expected to be set up with the help of a three-year mass campaign (1999 until 2001), i.e. the campaign called &apos;&apos;Solar - na klar.&apos;&apos; (solar - of course). [German] Der deutsche Markt fuer die technisch ausgereiften solarthermischen Anlagen zur Warmwassererzeugung waechst mit ca. 20% p.a., mit foerderpolitisch bedingten Schwankungen. Dieses Wachstum kann und soll systematisch gesteigert werden, mit folgenden Zielsetzungen: Praktischer Beitrag zur Erreichung der Klimaschutzziele der Bundesregierung; Schaffung zukunftsorientierter Arbeitsplaetze; Befoerderung oekologisch nachhaltiger Lebensstile und Konsummuster durch die Ueberzeugung der Verbraucher und weiterer Zielgruppen, dass es heute bereits sinnvoll ist, in die Nutzung der Solarenergie konkret einzusteigen und auch privat zu investieren. Diese Ziele sollen mithilfe einer auf drei Jahre angelegten Breitenkampagne (1999 bis 2001), d.h. der Kampagne &apos;Solar - na klar.&apos; erfolgen. (orig.)

  1. LIMITS ON QUAOAR&apos;S ATMOSPHERE

    Energy Technology Data Exchange (ETDEWEB)

    Fraser, Wesley C.; Gwyn, Stephen; Kavelaars, J. J. [Herzberg Institute of Astrophysics, 5071 W. Saanich Rd. Victoria, BCV9E 2E7 (Canada); Trujillo, Chad; Stephens, Andrew W. [Gemini Observatory, Northern Operations Center, 670 N A' ohoku Place, Hilo, HI 96720 (United States); Gimeno, German [Gemini Observatory, Southern Operations Center, c/o AURA, Casilla 603, La Serena (Chile); Brown, Michael E., E-mail: wesley.fraser@nrc.ca [California Institute of Technology, Division of Geological and Planetary Sciences, 1200 E. California Blvd., Pasadena, CA 91101 (United States)

    2013-09-10

    Here we present high cadence photometry taken by the Acquisition Camera on Gemini South, of a close passage by the {approx}540 km radius Kuiper belt object, (50000) Quaoar, of a r&apos; = 20.2 background star. Observations before and after the event show that the apparent impact parameter of the event was 0.&apos;&apos;019 {+-} 0.&apos;&apos;004, corresponding to a close approach of 580 {+-} 120 km to the center of Quaoar. No signatures of occultation by either Quaoar&apos;s limb or its potential atmosphere are detectable in the relative photometry of Quaoar and the target star, which were unresolved during closest approach. From this photometry we are able to put constraints on any potential atmosphere Quaoar might have. Using a Markov chain Monte Carlo and likelihood approach, we place pressure upper limits on sublimation supported, isothermal atmospheres of pure N{sub 2}, CO, and CH{sub 4}. For N{sub 2} and CO, the upper limit surface pressures are 1 and 0.7 {mu}bar, respectively. The surface temperature required for such low sublimation pressures is {approx}33 K, much lower than Quaoar&apos;s mean temperature of {approx}44 K measured by others. We conclude that Quaoar cannot have an isothermal N{sub 2} or CO atmosphere. We cannot eliminate the possibility of a CH{sub 4} atmosphere, but place upper surface pressure and mean temperature limits of {approx}138 nbar and {approx}44 K, respectively.

  2. The Waste Isolation Pilot Plant - An International Center of Excellence for &apos;&apos;Training in and Demonstration of Waste Disposal Technologies&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Matthews, Mark L.; Eriksson, Leif G.

    2003-02-25

    The Waste Isolation Pilot Plant (WIPP) site, which is managed and operated by the United States (U.S.) Department of Energy (USDOE) Carlsbad Field Office (CBFO) and located in the State of New Mexico, presently hosts an underground research laboratory (URL) and the world&apos;s first certified and operating deep geological repository for safe disposition of long-lived radioactive materials (LLRMs). Both the URL and the repository are situated approximately 650 meters (m) below the ground surface in a 250-million-year-old, 600-m-thick, undisturbed, bedded salt formation, and they have been in operation since 1982 and 1999, respectively. Founded on long-standing CBFO collaborations with international and national radioactive waste management organizations, since 2001, WIPP serves as the Center of Excellence in Rock Salt for the International Atomic Energy Agency&apos;s (IAEA&apos;s) International Network of Centers on &apos;&apos;Training in and Demonstration of Waste Disposal Technologies in Underground Research Facilities&apos;&apos; (the IAEA Network). The primary objective for the IAEA Network is to foster collaborative projects among IAEA Member States that: supplement national efforts and promote public confidence in waste disposal schemes; contribute to the resolution of key technical issues; and encourage the transfer and preservation of knowledge and technologies.

  3. Synthesis and evaluation of novel bifunctional chelating agents based on 1,4,7,10-tetraazacyclododecane-N,N&apos;,N'',N''&apos;-tetraacetic acid for radiolabeling proteins

    Energy Technology Data Exchange (ETDEWEB)

    Chappell, L.L.; Ma, D.; Milenic, D.E.; Garmestani, K.; Venditto, V.; Beitzel, M.P.; Brechbiel, M.W. E-mail: martinwb@mail.nih.gov

    2003-08-01

    Detailed synthesis of the bifunctional chelating agents 2-methyl-6-(p-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10 -tetraacetic acid (1B4M-DOTA) and 2-(p-isothiocyanatobenzyl)-5, 6-cyclohexano-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetate (CHX-DOTA) are reported. These chelating agents were compared to 2-(p-isothiocyanatobenzyl)-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid (C-DOTA) and 1, 4, 7, 10-Tetraaza-N-(1-carboxy-3-(4-nitrophenyl)propyl)-N&apos;, N&apos;&apos;, N&apos;'&apos;-tris(acetic acid) cyclododecane (PA-DOTA) as their {sup 177}Lu radiolabeled conjugates with Herceptin{sup TM}. In vitro stability of the immunoconjugates radiolabeled with {sup 177}Lu was assessed by serum stability studies. The in vivo stability of the radiolabeled immunoconjugates and their targeting characteristics were determined by biodistribution studies in LS-174T xenograft tumor-bearing mice. Relative radiolabeling rates and efficiencies were determined for all four immunoconjugates. Insertion of the 1B4M moiety into the DOTA backbone increases radiometal chelation rate and provides complex stability comparable to C-DOTA and PA-DOTA while the CHX-DOTA appears to not form as stable a {sup 177}Lu complex while exhibiting a substantial increase in formation rate. The 1B4M-DOTAmay have potential for radioimmunotherapy applications. Published by Elsevier Inc. All rights reserved.

  4. Guideline for sampling and analysis of &apos;tars&apos; and particles in biomass producer gases

    Energy Technology Data Exchange (ETDEWEB)

    Neeft, J.P.A. [ECN Biomass, Petten (Netherlands); Knoef, H.A.M. [Biomass Technology Group BTG, Enschede (Netherlands); Zielke, U. [DTI Danish Technological Institute, Aarhus (Denmark); Sjoestroem, K. [KTH Kungl Tekniska Hoegskolan, Stockholm (Sweden); Hasler, P. [Verenum, Zuerich (Switzerland); Simell, P.A.; Suomalainen, M. [VTT Technical Research Centre of Finland, Espoo (Finland); Dorrington, M.A. [CRE Group, Cheltenham (United Kingdom); Greil, C. [Lurgi Envirotherm, Frankfurt am Main (Germany)

    2000-07-01

    The further development of a Guideline (formerly Protocol) for sampling and analysis of &apos;tars&apos; from biomass producer gases is reported. This Guideline is being developed as a project within the European Fifth Framework Programme with additional partners from Switzerland and North-America. In this paper an outline and the principle of the Guideline are given. The Guideline is based on isokinetic sampling of particles and &apos;tar&apos; from the main producer gas duct, particle filtration at high temperature, gas cooling in a liquid quench, &apos;tar&apos; absorption in a solvent at low temperatures, an optional backup adsorber, and flow measurement and control. The Guideline gives a definition for &apos;Gravimetric tar&apos; which is the &apos;tar&apos; number to be determined by the Guideline. Also, the Guideline gives procedures for compound analysis by gas chromatography - mass spectrometry (GC-MS) or gas chromatography - Flame Ionization Detector (GC-FID). Moreover, in this paper the major choices that were made to reach the first version of the Guideline are explained. Finally, at the end of the paper it is described how and on what time scale the development of the Guideline will be completed. The full text of the Guideline is available on the Internet at www.tarweb.net. 11 refs.

  5. Maintenance - practically changing perception via technology - the &apos;PLAN&apos; view

    Energy Technology Data Exchange (ETDEWEB)

    Jennings, I.D. [Monition Ltd, Nottinghamshire (United Kingdom)

    2001-07-01

    The author and presenter of this paper intends to show how the PLAN project is helping to focus engineering professionals minds on &apos;helping themselves&apos; when it comes to Maintenance matters. As co- ordinator of the Maintenance Cluster of the PLAN project, the presenter will describe how the work of three Cluster Tasks, has already convinced many scientific and engineering biased professionals that adopting certain key philosophies can assist the Maintenance function to achieve performance standards previously thought unattainable. The paper will show how the use of the very latest technological developments, particularly in the Condition Monitoring field, together with &apos;Accountancy Justification&apos; can bring about &apos;Purse String Loosening Effects&apos;. The presentation will go on to show how the &apos;Purse String Loosening Effects&apos; become self perpetuating and can catapult the Maintenance function to the forefront of a business. In conclusion the author will show how the PLAN project work, within the Maintenance Cluster, has assessed the State of the Art in many areas of Maintenance Engineering and will go on to describe some of the contents of an &apos;Easy to Understand&apos;, practical guide to really, achieving business results through Focused Maintenance, which is to be produced. (orig.)

  6. [ApoE polymorphisms and dopaminergic replacement therapy in Parkinson's disease].

    Science.gov (United States)

    Cervantes-Arriaga, Amin; Rodríguez-Violante, Mayela; González-Latapí, Paulina; Dávila-Ortiz de Montellano, David José; Yescas, Petra; Alonso-Vilatela, Elisa

    2014-01-01

    INTRODUCCIÓN: se ha propuesto que la expresión de los polimorfismos de la apolipoproteína E (apoE) es un factor predisponente para el desarrollo temprano de psicosis en los pacientes con enfermedad de Parkinson. La relación entre el genotipo de la apoE y el desarrollo de complicaciones motoras es controvertida. El objetivo de esta investigación fue determinar la relación entre los polimorfismos de la apoE y su frecuencia alélica y el desarrollo de complicaciones secundarias al reemplazo dopaminérgico. MÉTODOS: se evaluaron 231 pacientes con diagnóstico de enfermedad de Parkinson. La presencia de complicaciones fue determinada por un neurólogo y se realizó la genotipificación de los polimorfismos de la apoE. Se utilizó la chi cuadrada para determinar la relación entre la presencia o ausencia de las complicaciones estudiadas y el genotipo de la apoE.

  7. Environmental criminality; Criminalita&apos; ambientale. Un&apos;analisi economica

    Energy Technology Data Exchange (ETDEWEB)

    Percoco, M. [Milan Univ. Bocconi, Milan (Italy)

    2001-07-01

    The aim of this paper is to provide a theoretical rationale for environmental crimes. In particular, it is studied the illegal market of industrial hazardous waste management and it is presented a model with Government, industry and illegal dumping industry interacting to reach the equilibrium. Several policy actions are tested, in particular it is appraised a special Authority constitution to prevent and repress environmental crimes. Finally, following the theoretical findings of the model, are provided some comments to recent law proposals. [Italian] Lo scopo del presente saggio e&apos; quello di fornire una ratio dal punto di vista della teoria economica ai fenomeni di criminalita&apos; ambientale. Argomento principale e&apos; il mercato che viene a crearsi a seguito dello smaltimento illecito dei rifiuti industriali ed in tal senso si presenta un modello in cui Governo, industrie ed imprese per lo smaltimento illecito interagiscono sino a raggiungere un equilibrio. Sono altresi&apos; testate alcune possibilita&apos; d&apos;intervento da parte del Settore Pubblico per contrastare il fenomeno da cui si originano forti esternalita&apos; negative, quindi si studia la fattibilita&apos; di un&apos;apposita Autorita&apos; che coordini le azioni di prevenzione e repressione. Infine, in base ai risultati raggiunti nella sezione teorica, si propongono alcuni commenti alla recente proposta di legge in materia di reati ambientali.

  8. ApoE receptor 2 regulates synapse and dendritic spine formation.

    Directory of Open Access Journals (Sweden)

    Sonya B Dumanis

    Full Text Available BACKGROUND: Apolipoprotein E receptor 2 (ApoEr2 is a postsynaptic protein involved in long-term potentiation (LTP, learning, and memory through unknown mechanisms. We examined the biological effects of ApoEr2 on synapse and dendritic spine formation-processes critical for learning and memory. METHODOLOGY/PRINCIPAL FINDINGS: In a heterologous co-culture synapse assay, overexpression of ApoEr2 in COS7 cells significantly increased colocalization with synaptophysin in primary hippocampal neurons, suggesting that ApoEr2 promotes interaction with presynaptic structures. In primary neuronal cultures, overexpression of ApoEr2 increased dendritic spine density. Consistent with our in vitro findings, ApoEr2 knockout mice had decreased dendritic spine density in cortical layers II/III at 1 month of age. We also tested whether the interaction between ApoEr2 and its cytoplasmic adaptor proteins, specifically X11α and PSD-95, affected synapse and dendritic spine formation. X11α decreased cell surface levels of ApoEr2 along with synapse and dendritic spine density. In contrast, PSD-95 increased cell surface levels of ApoEr2 as well as synapse and dendritic spine density. CONCLUSIONS/SIGNIFICANCE: These results suggest that ApoEr2 plays important roles in structure and function of CNS synapses and dendritic spines, and that these roles are modulated by cytoplasmic adaptor proteins X11α and PSD-95.

  9. The frequency of down&apos;s syndrome in the city of Ozyorsk located near the nuclear complex &apos;'Mayak'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Petrushkina, N.P.; Okatenko, P.V.; Kabirova, N.R.; Koshurnikova, N.A. [Branch No 1 of the State Research Center, Ozyorsk (Russian Federation). Biophysics Inst.

    2000-05-01

    The aim of the study is to assess the frequency of Down&apos;s syndrome (DS) among newborns in the city of Ozyorsk located near the nuclear complex Mayak&apos;&apos;. The study has been conducted on the basis of the cohort, which includes 18,499 children born in Ozyorsk in 1974-1988. Information on cases of DS has been abstracted from newborn records at the city maternity hospital. The frequency of DS in Ozyorsk is 1.4 cases per 1,000 newborns. According to some published data, the population frequency of this syndrome is 1.25-1.42 cases per 1,000 newborns. The frequency of DS among children whose parents were occupationally exposed to radiation has been studied. The cohort has been divided into two subcohorts based on whether or not parents worked at Mayak. In 5,303 children either one or both parents worked at Mayak. The comparison group includes 13,196 children whose parents never worked at Mayak. In the children, whose parents worked at Mayak, the frequency of DS is 1.32 cases per 1000, and in the comparison group - 1.44 cases per 1000 (the difference is not statistically significant). Parental radiation doses by the time of conception of children with DS are in the range from 0.65 to 10.31 cSv. Our data confirm the effect of maternal age on the frequency of DS. The frequency of DS in children born to mother under the age of 30 is 0.94 per 1,000 and in children born to mothers older than 30 years - 3.87 per 1,000. So the frequency of DS among children born in the city located near the nuclear complex does not exceed the spontaneous level. No association has been detected between the frequency of DS and preconception parental radiation exposure. The effect of maternal age has been confirmed. (author)

  10. HERSCHEL&apos;s &apos;&apos;COLD DEBRIS DISKS&apos;&apos;: BACKGROUND GALAXIES OR QUIESCENT RIMS OF PLANETARY SYSTEMS?

    Energy Technology Data Exchange (ETDEWEB)

    Krivov, A. V.; Loehne, T.; Mutschke, H.; Neuhaeuser, R. [Astrophysikalisches Institut und Universitaetssternwarte, Friedrich-Schiller-Universitaet Jena, Schillergaesschen 2-3, D-07745 Jena (Germany); Eiroa, C.; Marshall, J. P.; Mustill, A. J. [Departamento de Fisica Teorica, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, E-28049 Madrid (Spain); Montesinos, B. [Departamento de Astrofisica, Centro de Astrobiologia (CAB, CSIC-INTA), ESAC Campus, P.O. Box 78, E-28691 Villanueva de la Canada, Madrid (Spain); Del Burgo, C. [Instituto Nacional de Astrofisica, Optica y Electronica (INAOE), Apartado Postal 51 y 216, 72000 Puebla, Pue. (Mexico); Absil, O. [Institut d' Astrophysique et de Geophysique, Universite de Liege, Allee du 6 Aout 17, B-4000 Liege (Belgium); Ardila, D. [NASA Herschel Science Center, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Augereau, J.-C.; Ertel, S.; Lebreton, J. [UJF-Grenoble 1/CNRS-INSU, Institut de Planetologie et d' Astrophysique de Grenoble (IPAG), UMR 5274, F-38041 Grenoble (France); Bayo, A. [European Southern Observatory, Alonso de Cordova 3107, Vitacura, Santiago (Chile); Bryden, G. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Danchi, W. [NASA Goddard Space Flight Center, Exoplanets and Stellar Astrophysics, Code 667, Greenbelt, MD 20771 (United States); Liseau, R. [Department of Earth and Space Sciences, Chalmers University of Technology, Onsala Space Observatory, SE-43992, Onsala (Sweden); Mora, A. [ESA-ESAC Gaia SOC, P.O. Box 78, E-28691 Villanueva de la Canada, Madrid (Spain); Pilbratt, G. L., E-mail: krivov@astro.uni-jena.de [ESA Astrophysics and Fundamental Physics Missions Division, ESTEC/SRE-SA, Keplerlaan 1, 2201 AZ Noordwijk (Netherlands); and others

    2013-07-20

    than a few kilometers in size. If larger planetesimals were present, then they would stir the disk, triggering a collisional cascade and thus causing production of small debris, which is not seen. Thus, planetesimal formation, at least in the outer regions of the systems, has stopped before &apos;cometary&apos; or &apos;asteroidal&apos; sizes were reached.

  11. Alaska&apos;s renewable energy potential.

    Energy Technology Data Exchange (ETDEWEB)

    2009-02-01

    This paper delivers a brief survey of renewable energy technologies applicable to Alaska&apos;s climate, latitude, geography, and geology. We first identify Alaska&apos;s natural renewable energy resources and which renewable energy technologies would be most productive. e survey the current state of renewable energy technologies and research efforts within the U.S. and, where appropriate, internationally. We also present information on the current state of Alaska&apos;s renewable energy assets, incentives, and commercial enterprises. Finally, we escribe places where research efforts at Sandia National Laboratories could assist the state of Alaska with its renewable energy technology investment efforts.

  12. Reply to comment on &apos;Faraday&apos;s law via the magnetic vector potential&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Redzic, Dragan V [Faculty of Physics, University of Belgrade, PO Box 368, 11001 Belgrade (Yugoslavia)

    2008-01-15

    Kholmetskii, Missevitch and Yarman correct an error that appeared in my recent note on Faraday&apos;s law and present an alternative derivation of the law. The wrong step in the derivation is pointed out. (letters and comments)

  13. &apos;&apos;After the Genome 5 Conference&apos;&apos; to be held October 6-10, 1999 in Jackson Hole, Wyoming

    Energy Technology Data Exchange (ETDEWEB)

    Roger Brent

    1999-10-06

    OAK B139 The postgenomic era is arriving faster than anyone had imagined--sometime during 2000 we&apos;ll have a large fraction of the human genome sequence. Heretofore, our understanding of function has come from non-industrial experiments whose conclusions were largely framed in human language. The advent of large amounts of sequence data, and of &apos;&apos;functional genomic&apos;&apos; data types such as mRNA expression data, have changed this picture. These data share the feature that individual observations and measurements are typically relatively low value adding. Such data is now being generated so rapidly that the amount of information contained in it will surpass the amount of biological information collected by traditional means. It is tantalizing to envision using genomic information to create a quantitative biology with a very strong data component. Unfortunately, we are very early in our understanding of how to &apos;&apos;compute on&apos;&apos; genomic information so as to extract biological knowledge from i t. In fact, some current efforts to come to grips with genomic information often resemble a computer savvy library science, where the most important issues concern categories, classification schemes, and information retrieval. When exploring new libraries, a measure of cataloging and inventory is surely inevitable. However, at some point we will need to move from library science to scholarship.We would like to achieve a quantitative and predictive understanding of biological function. We realize that making the bridge from knowledge of systems to the sets of abstractions that constitute computable entities is not easy. The After the Genome meetings were started in 1995 to help the biological community think about and prepare for the changes in biological research in the face of the oncoming flow of genomic information. The term &apos;&apos;After the Genome&apos;&apos; refers to a future in which complete inventories of the gene products of

  14. Whose education affects a child&apos;s nutritional status? From parents&apos; to household&apos;s education

    Directory of Open Access Journals (Sweden)

    Francesco Burchi

    2012-11-01

    Full Text Available BACKGROUND The paper engages in the ongoing debate regarding the determinants of child nutrition in developing countries and stresses the potential contribution of the education of household members other than the child&apos;s parents. OBJECTIVE The aim of the paper is threefold: (1 to verify whether there is evidence of the key role of parents&apos; education for children&apos;s nutrition; (2 to explore the possible presence of the externalities generated by the literacy of household members different from the child&apos;s parents; (3 to test whether there is difference in the influence of these variables on the two indicators of child nutrition, child height-for-age and weight-for-age. METHODS The determinants of child nutrition were analyzed by estimating a series of econometric models through OLS regressions applied on data from the 2003 DHS survey in Mozambique. By means of seemingly unrelated regression together with formal testing we compared the impact of the covariates on the two outcomes. RESULTS In line with previous studies, we find that one year of mother&apos;s education increases their children&apos;s height-for-age and weight-for-age z-scores by nearly 0.025 and 0.015. The presence of another literate household member has a significant, though limited, effect on child height while it has no influence on child weight. Lastly, there is no statistically significant difference in the effect of parents&apos; education on the two indicators while our measure of proximate literacy has a significantly larger impact on child height. CONCLUSIONS These findings should orient policy-makers toward income-augmenting and education-enhancing policies: the importance of non-parents&apos; literacy opens a further space for investment in education.

  15. LXR agonist increases apoE secretion from HepG2 spheroid, together with an increased production of VLDL and apoE-rich large HDL

    Directory of Open Access Journals (Sweden)

    Koike Kazuhiko

    2011-08-01

    Full Text Available Abstract Background The physiological regulation of hepatic apoE gene has not been clarified, although the expression of apoE in adipocytes and macrophages has been known to be regulated by LXR. Methods and Results We investigated the effect of TO901317, a LXR agonist, on hepatic apoE production utilizing HepG2 cells cultured in spheroid form, known to be more differentiated than HepG2 cells in monolayer culture. Spheroid HepG2 cells were prepared in alginate-beads. The secretions of albumin, apoE and apoA-I from spheroid HepG2 cells were significantly increased compared to those from monolayer HepG2 cells, and these increases were accompanied by increased mRNA levels of apoE and apoA-I. Several nuclear receptors including LXRα also became abundant in nuclear fractions in spheroid HepG2 cells. Treatment with TO901317 significantly increased apoE protein secretion from spheroid HepG2 cells, which was also associated with the increased expression of apoE mRNA. Separation of the media with FPLC revealed that the production of apoE-rich large HDL particles were enhanced even at low concentration of TO901317, and at higher concentration of TO901317, production of VLDL particles increased as well. Conclusions LXR activation enhanced the expression of hepatic apoE, together with the alteration of lipoprotein particles produced from the differentiated hepatocyte-derived cells. HepG2 spheroids might serve as a good model of well-differentiated human hepatocytes for future investigations of hepatic lipid metabolism.

  16. Placas oclusais para tratamento do bruxismo do sono: revisão sistemática Cochrane

    OpenAIRE

    Macedo, Cristiane Rufino

    2007-01-01

    Contexto: Bruxismo do sono é uma atividade do sistema estomatognático caracterizada pelo ranger ou apertamento dos dentes durante o sono. Vários tratamentos para o bruxismo do sono têm sido propostos, entre eles o farmacológico, o psicológico e odontológico. Objetivo: Avaliar a efetividade das placas oclusais para o tratamento do bruxismo do sono comparada às intervenções alternativas ou ao não tratamento. Estratégia de pesquisa: Nós procuramos ensaios clínicos controlados randomizados ...

  17. Influência do tratamento da dentina radicular na resistência adesiva de pinos de fibra de vidro

    OpenAIRE

    Feuser, Lizette

    2006-01-01

    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Odontologia. O objetivo deste estudo in vitro foi avaliar a influência de tratamento da dentina radicular, após preparo mecânico para cimentação, na resistência adesiva de pinos de fibra de vidro, sob teste de cisalhamento por extrusão. Cem caninos humanos tratados endodonticamente, e vinte sem tratamento formaram grupos de acordo com o tratamento da dentina radicular, com ...

  18. TRATAMENTO DO LIXIVIADO DE ATERRO DE RESÍDUOS SÓLIDOS URBANOS POR PROCESSO FENTON

    Directory of Open Access Journals (Sweden)

    Victor Wegner Maus

    2009-09-01

    Full Text Available O lixiviado gerado em aterros sanitários pela decomposição dos resíduos sólidos com presença de água de infiltração possui grande potencial poluidor, devido à elevada concentração de substâncias tóxicas e a sua baixa biodegradabilidade. A coagulação química pode ser uma alternativa para o tratamento de efluentes com essas características. O trabalho teve como objetivo avaliar a eficiência do processo Fenton no tratamento de lixiviado gerado em aterros sanitários de resíduos sólidos urbanos. As amostras de lixiviado foram coletadas no aterro controlado do município de Santa Maria – RS. No experimento foram testados cinco tratamentos com diferentes proporções de reagentes (H2O2 e FeSO4 TH2O2/FeSO4: T0,8, T2,0, T3,0, T4,0 e T6,0. Pelos resultados do experimento com processo Fenton verifica-se uma eficiência média na remoção da demanda química de oxigênio (DQO de 47,9%, na turbidez de 53,0% e na cor de 70,7%. Os valores médios da demanda bioquímica de oxigênio (DBO e da condutividade elétrica aumentaram em 31,3% e 27,1%, respectivamente. No tratamento T0,8 constatou-se a maior remoção da DQO e o maior aumento da biodegradabilidade. O processo Fenton aplicado no tratamento de lixiviado reduz a DQO e aumenta a DBO, em outras palavras, aumenta a biodegradabilidade do efluente. Esse processo pode ser utilizado como pré-tratamento de um sistema biológico para efluentes de aterros sanitários.

  19. &apos;'Live'&apos; Prussian blue fading by time-resolved X-ray absorption spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Gervais, Claire [Smithsonian Institution Museum Conservation Institute, Suitland, MD (United States); Bern University of the Arts, Bern (Switzerland); Languille, Marie-Angelique [Synchrotron SOLEIL, IPANEMA, USR 3461 CNRS/MCC, Gif-sur-Yvette (France); Reguer, Solenn [Synchrotron SOLEIL, DiffAbs beamline, Gif-sur-Yvette (France); Gillet, Martine [Museum national d' histoire naturelle, Centre de Recherche sur la Conservation des Collections, Paris (France); Vicenzi, Edward P. [Smithsonian Institution Museum Conservation Institute, Suitland, MD (United States); Chagnot, Sebastien; Baudelet, Francois [Synchrotron SOLEIL, ODE beamline, Gif-sur-Yvette (France); Bertrand, Loic [Synchrotron SOLEIL, IPANEMA, USR 3461 CNRS/MCC, Gif-sur-Yvette (France); Synchrotron SOLEIL, Gif-sur-Yvette (France)

    2013-04-15

    Prussian blue (PB) is an artists&apos; pigment that has been frequently used in many artworks but poses several problems of conservation because of its fading under light and anoxia treatment. PB fading is due to the reduction of iron(III) into iron(II) and depends a lot on the object investigated. Due to the complexity of the structure, the precise physico-chemical mechanisms behind the redox process remain obscure. In this paper, we present a procedure to investigate light- and anoxia-induced fading of PB-paper samples by means of time resolved X-ray absorption spectroscopy performed at the Fe K-edge. A system composed of a visible light source and a flux-controlled environmental cell allowed light, gas and humidity to be modified in situ. The synchrotron X-ray beam was evidenced to induce a reduction of PB and to play a major role in the kinetics. The analysis of the PB fading kinetics of a sample submitted to various gas and light environments showed that both synchrotron beam and anoxia were influencing PB reduction in a correlated way. In comparison, light was found to play a minor role. Finally, we have demonstrated that the type of paper substrate could influence significantly the kinetics of reduction. Several hypotheses to explain the correlation between PB reduction mechanism and substrate are presented. (orig.)

  20. Assessment of the biological effects of &apos;strange&apos; radiation

    Energy Technology Data Exchange (ETDEWEB)

    Pryakhin, E.A.; Tryapitsina, G.A. [Chelyabinsk State University, Chelyabinsk (Russian Federation); Urutskoyev, L.I. [RECOM Company, Kurchatov Russian Research Institute, Moscow (Russian Federation); Akleyev, A.V. [Urals Research Center for Radiation Medicine, Chelyabinsk (Russian Federation)

    2006-07-01

    The results from studies of the effects produced by electrical explosions of foils made from super pure materials in water point to the emergence of new chemical elements. An additional finding was the discharge of &apos;strange&apos; radiation accompanying the transformation of chemical elements. However, currently, the mechanism involved in the interaction between &apos;strange&apos; radiation and a substance or a biological entity remains obscure. Therefore, the aim of the present research is to investigate the biological effects of the &apos;strange&apos; radiation. Pilot studies were performed at the RECOM RRC &apos;Kurchatov Institute&apos; in April-May of 2004. The animals used in the experiment were female mice of C57Bl/6 line aged 80 days with body weight 16-18 g. The animals were exposed to radiation discharged during explosions of Ti foils in water and aqueous solutions. The cages with animals were placed at 1 m from the epicenter of the explosion. Explosions were carried out on the 19. (3 explosions), 20. (4 explosions) and 22. (3 explosions) of April, 2004 (explosions No1373 - No1382, respectively). The animals were assigned to 4 experimental groups comprised of 17-20 mice per group. The animals received experimental exposure within 1, 2 and 3 days of the experiment. In total, the experimental groups were exposed to 3, 7 and 10 explosions, respectively. In order to identify the biological reactions, the following parameters were estimated: number of nucleated cells in the bone marrow, number of CFU in the spleen after additional gamma-irradiation (6 Gy), cell composition of the bone marrow, the rate of erythrocytes with the different level of maturation in the bone marrow, the rate of erythrocytes with the micronuclei in the bone marrow, the reaction of bone marrow cells to additional gamma-irradiation (2 Gy), number of leucocytes in the peripheral blood, and cell composition of the peripheral blood. The following conclusions were drawn from these

  1. &apos;Carbon-Money Exchange&apos; to contain global warming and deforestation

    Energy Technology Data Exchange (ETDEWEB)

    Nagase, Kozo E-mail: nagase@de.mbn.or.jp

    2005-07-01

    This paper builds a basic theory of &apos;Carbon-Money Exchange&apos; in which carbon as currency in nature&apos;s household (ecosystems) and money as currency in humankind&apos;s household (economy) are exchanged just like in a foreign exchange. The simple chemical equation below makes it possible (CO{sub 2}{yields}C+O{sub 2}=C+O{sub 2}{yields}CO{sub 2}). The left-hand side represents the work of plants to remove atmospheric CO{sub 2}. The right-hand side represents the work of humans as fossil fuel consumers to produce it. The exchange of the two currencies is possible by copying the fossil fuel market. The paper concludes that this new exchange can automatically contain global warming and deforestation, replacing onerous emissions trading. Moreover, it could revolutionize the conventional economy, creating counter-capitalism, or &apos;carbonism&apos;.

  2. On the expression &apos;external calibration&apos; in atomic spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Kantor, Tibor [Geological Institute of Hungary, Stefania Ave 14, 1143 Budapest (Hungary)], E-mail: kantib@t-online.hu

    2008-04-15

    The expressions &apos;calibration&apos; and &apos;external calibration&apos; appear together in the present literature of atomic spectrometry resulting in a dilemma of understanding and correct use. It is examined how the IUPAC can provide a guidance to the solution of this problem by recalling the definitions of related terms of optical, mass and X-ray atomic spectrometry techniques. The introduction and definition of these expressions in widely used text books are investigated and statistically evaluated for the articles published during the last 30 years in the periodical Spectrochimica Acta Part B. For the elimination of the literary difficulties with the use of the term &apos;calibration&apos;, attributes are proposed to express the degree of matrix matching of standards and samples.

  3. Measurement of the branching ratio for UPSILON/sup &apos;//sup &apos;/. --> mu mu

    Energy Technology Data Exchange (ETDEWEB)

    Kaarsberg, T.; Lee-Franzini, J.; Lovelock, D.M.J.; Narain, M.; Schamberger, R.D.; Sontz, S.B.; Yanagisawa, C.; Willins, J.; Franzini, P.; Tuts, P.M.; and others

    1987-04-01

    Using the CUSB-II detector at the Cornell Electron Storage Ring, we have measured B..mu mu.., the branching fraction into muons, of the UPSILON&apos;&apos; meson. We find B/sub ..mu..//sub ..mu../(UPSILON&apos;&apos;) = (1.53 +- 0.33 +- 0.21)%, from which the UPSILON&apos;&apos; total decay width is 25.5 +- 5.0 keV. From this result we obtain ..cap alpha../sub s/ = 0.170/sub -0.012//sup +0.015/, ..lambda../sub M//sub S-bar/ = 148/sub -39//sup +56/ MeV. (MS-bar denotes the modified minimal-subtraction scheme).

  4. Cerebral glucose metabolism in Wernicke&apos;s, Broca&apos;s, and conduction aphasia

    Energy Technology Data Exchange (ETDEWEB)

    Metter, E.J.; Kempler, D.; Jackson, C.; Hanson, W.R.; Mazziotta, J.C.; Phelps, M.E.

    1989-01-01

    Cerebral glucose metabolism was evaluated in patients with either Wernicke&apos;s (N = 7), Broca&apos;s (N = 11), or conduction (N = 10) aphasia using /sup 18/F-2-fluoro-2-deoxy-D-glucose with positron emission tomography. The three aphasic syndromes differed in the degree of left-to-right frontal metabolic asymmetry, with Broca&apos;s aphasia showing severe asymmetry and Wernicke&apos;s aphasia mild-to-moderate metabolic asymmetry, while patients with conduction aphasia were metabolically symmetric. On the other hand, the three syndromes showed the same degree of metabolic decline in the left temporal region. The parietal region appeared to separate conduction aphasia from both Broca&apos;s and Wernicke&apos;s aphasias. Common aphasic features in the three syndromes appear to be due to common changes in the temporal region, while unique features were associated with frontal and parietal metabolic differences.

  5. ApoE knockout and knockin mice: the history of their contribution to the understanding of atherogenesis.

    Science.gov (United States)

    Getz, Godfrey S; Reardon, Catherine A

    2016-05-01

    ApoE is a multifunctional protein that is expressed by many cell types that influences many aspects of cardiovascular physiology. In humans, there are three major allelic variants that differentially influence lipoprotein metabolism and risk for the development of atherosclerosis. Apoe-deficient mice and human apoE isoform knockin mice, as well as hypomorphic Apoe mice, have significantly contributed to our understanding of the role of apoE in lipoprotein metabolism, monocyte/macrophage biology, and atherosclerosis. This brief history of these mouse models will highlight their contribution to the understanding of the role of apoE in these processes. These Apoe(-/-) mice have also been extensively utilized as an atherosensitive platform upon which to assess the impact of modulator genes on the development and regression of atherosclerosis.

  6. Contribution to the study of the sintering of uranium oxide; Contribution a l&apos;etude du frittage de l&apos;oxyde d&apos;uranium

    Energy Technology Data Exchange (ETDEWEB)

    Bel, A.; Carteret, Y. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    The sintering ofnium oxide has been considered and the following factors have been particularly taken in consideration: - the particle size and the particles in shape of the initial powder, - the specific area of the initial powder, - the chemical composition of the oxide, - and the medium in which the sintering was carried out. A method of sintering uranium oxide on semi-industrial scale is presented. (author)Fren. [French] On xamine l&apos;influence de differents facteurs sur le frittage de l&apos;oxyde d&apos;uranium. Sont particulierement prises en consideration: - la taille et la forme des grains de la poudre initiale, - la surface specifique de la poudre initiale, - la composition chimique de l&apos;oxyde, - ainsi que la nature de l&apos;atmosphere durant le frittage. D&apos;autre part, une technique de frittage de l&apos;oxyde d&apos;uranium a l&apos;echelle semi-industrielle est presentee. (auteur)

  7. Characterization and evaluation of residue &apos;grits&apos; of the cellulose industry; Caracterizacao e avaliacao do resisduo &apos;grits&apos; da industria de celulose

    Energy Technology Data Exchange (ETDEWEB)

    Destefani, A.Z.; Santos, M.M.; Holanda, J.N.F. [Universidade Estadual do Norte Fluminense Darcy Ribeiro (LAMAV/CCT/UENF), Campos dos Goytacazes, RJ (Brazil). Lab. de Materiais Avancados

    2010-07-01

    The cellulose industry generates huge amounts of solid waste residue called &apos;grits&apos;. These wastes have been willing over time in landfills near the mills. However, this type of disposal is not environmentally friendly and can cause degradation and environmental pollution. In addition, environmental legislation increasingly severe and the high costs of landfill have led the search for new alternatives for final disposition of this abundant waste. In this context, this study is to characterize waste grits, generated by the cellulose industry in the region of Aracruz-ES. The residue samples were characterized in terms of chemical composition, X-ray diffraction, particle size distribution and thermal analysis (DTA and TGA). The characterization of the residual &apos;grits&apos; demonstrated its potential as a feedstock for production of soil-cement bricks. (author)

  8. First forum &apos;'BISE'&apos; for: the intelligent energy in the municipalities and the new member states, of candidate countries and western Balkans; Premier forum &apos;'BISE'&apos; pour: l&apos;energie intelligente dans les minicipalites des nouveaux etats membres, des pays candidats et des Balkans occidentaux

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    The european commission and the european association of municipalities (Energie Cites) established a permanent &apos;&apos;Intelligent Energy Forum of European Municipalities&apos;&apos; (named BISE Forum) as form of periodical information exchange between municipal associations and other potential partners in Europe. In the framework of the reduction of the sustainable energy gap between the Central and Eastern European Countries and the most advanced energy-efficient EU 15 countries, the aim of this forum is to promote the creation of national energy cities networks, to integrate the initiatives and networks at an European scale and to promote the idea of an European Emergency Plan in order to improve energy efficiency in Eastern European Countries as quickly as possible. This document presents the proceedings and a selection of cases studies linked to the first BISE Forum. (A.L.B.)

  9. Industrial robots in car construction - on the way to &apos;automized Fordism&apos;. Industrieroboter im Automobilbau - auf dem Sprung zum &apos;automatisierten Fordismus&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Malsch, T.; Dohse, K.; Juergens, U.

    1984-05-01

    Since the end of the 70s international car manufacturers have adopted a new strategy with regard to the use of robots. Companies all over the world - headed by the Japanese car makers - decided not to &apos;dabble&apos; with industrial robots anymore but to &apos;blockbust&apos; with them. Complete production processes were literally turned inside out by the compact use of robots in waves, and adjusted to the requirements of flexible manufacturing technology. To deal with the characteristic conditions and features of the new strategy as well as its implications for labour policy, it is also necessary to examine the use of robots at the plant level. This study comes to the conclusion that the plant use of robots by no means follows a continuous curve, as would appear to be the case in industry and group statistics on the development of robot inventory. (orig./HW).

  10. Esthesioneuroblastoma in Maffucci&apos;s syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Kurian, Sobha; Crowell, Edward B. [West Virginia University, Section of Hematology/Oncology, Department of Medicine, Health Science Center, Morgantown (United States); Ertan, Esmer; Rassekh, Christopher [West Virginia University, Department of Otolaryngology, Morgantown (United States); Ducatman, Barbara [West Virginia University, Department of Pathology, Morgantown (United States)

    2004-10-01

    Maffucci&apos;s syndrome consists of multiple cutaneous hemangiomas, dyschondroplasia, and enchondromas with potential for malignant change. We report a case of a 33-year-old man with Maffucci&apos;s syndrome who presented with a several month history of nasal congestion, facial pain, and diminished vision in his left eye. Radiological studies showed a large soft tissue mass centered in the sinonasal area, extending bilaterally into maxillary sinuses and orbits with compression of left optic nerve. Biopsy of the mass showed esthesioneuroblastoma (olfactory neuroblastoma). Chemotherapy resulted in initial improvement, but the tumor recurred and did not respond to further treatment, resulting in his death. Sarcomatous tumors are reported in Maffucci&apos;s syndrome, but this is a rare case of a neuroendocrine tumor in a patient with Maffucci&apos;s syndrome. (orig.)

  11. The apo riboswitch as a molecular hydra.

    Science.gov (United States)

    Wedekind, Joseph E

    2010-07-14

    Riboswitches "sense" metabolites but knowledge is sparse for structures without bound ligand. Stoddard et al. (2010) determined an apo riboswitch structure "closed" to metabolite binding. Further SAXS, biochemical, and computational analyses support ensemble behavior with interconverting open and closed conformations.

  12. Teleoperators: Man&apos;s Machine Partners

    Energy Technology Data Exchange (ETDEWEB)

    Corliss, William R.

    1972-01-01

    This booklet is about teleoperators, a class of machines that augment man rather than replace him. Teleoperators have the ability to add to man&apos;s strength, his reach, and his ability to work in hostile environments.

  13. Reconstruction of surface morphology from coherent scattering of &apos;'white'&apos; synchrotron radiation in hard X-ray regime

    Energy Technology Data Exchange (ETDEWEB)

    Sant, Tushar

    2009-07-01

    Energy Dispersive Reflectometry (EDR) beamline at BESSY II provides &apos;'white'&apos; X-rays in the useful energy range of 5apos;'trivial'&apos; samples to determine the so called apparatus function. In addition I measured coherent reflectivity maps from thin film of highly scattering material of Pt with high atom number, Z=78 and patterned semiconducting surface like a GaAs surface grating which provides a certain periodicity in the measured scattering intensity. Finally I measured the surface speckles from a spatially confined Si wafer under the constraint that the size of the sample is smaller than the footprint of the incoming beam at the sample position. To reconstruct surface morphology from coherent reflectivity data is a typical inverse problem. Conventional phase retrieval algorithms like Gerchberg-Saxton (GS) algorithm, error reduction (ER) algorithm, hybrid input-output (HIO) algorithm are used in earlier work by other authors. I modified the conventional GS algorithm and ER algorithm which takes into account the additional Fresnel propagator term and also the illumination function at the sample position. I tested the modified algorithm successfully for a model surface in the form of a surface grating. I used the modified algorithm to reconstruct surface morphology from various static speckle measurements I performed at EDR beamline. The surface profiles reconstructed for different samples from the data at different energies (below the critical energy for the material at a particular incident angle) show almost the same roughness behavior for surface height with mean roughness of {proportional_to}1 nm. With the static speckle data I measured I could retrieve a one-dimensional picture of the sample surface with spatial

  14. The &apos;2000-Watt per person&apos;- industrial society - Utopia, vision or necessity?; Die &apos;2000 Watt pro Kopf&apos;-Industriegesellschaft - Utopie, Vision oder Notwendigkeit?

    Energy Technology Data Exchange (ETDEWEB)

    Jochem, E

    2006-07-01

    This short article takes a look at the &apos;2000-Watt per person&apos; concept initially developed at the Swiss Federal Institute of Technology (ETH) in Zurich, Switzerland, in 1998. The author is of the opinion that the concept is not utopian but a vision that can be realised - providing it is accepted socially and that politics can implement it. Further work on the concept done at the ETH over the years is listed and commented on. A diagram provides an overview of energy resources, energy transformation and energy flows to final energy consumption. The question as to if the realisation of such a &apos;2000-Watt&apos;-society is actually necessary is posed.

  15. Berlusconi&apos;s power problems

    Energy Technology Data Exchange (ETDEWEB)

    Newman, N.

    2011-05-15

    The declining political influence of Silvio Berlusconi&apos;s government and fervent local opposition to new plants, particularly nuclear, has left the Italian power sector reliant on imports to address continuing power shortages. 4 figs.

  16. The &apos;&apos;CombiPower process&apos;&apos; - a possibility for decentral generation of electric current, heat and industrial gas from biomass; Der &apos;'CombiPower-Prozess'&apos; eine Moeglichkeit der dezentralen Erzeugung von Strom, Waerme und Industriegas aus Biomasse

    Energy Technology Data Exchange (ETDEWEB)

    Topf, N.; Berger, M.; Palitzsch, G.; Schroeder, S. [VER Verfahrensingenieure GmbH, Dresden (Germany)

    2007-07-01

    The presented method, which is characterised by the combination of fluidized bed gasification with fluidized bed cooling of the combustion gas (tar and dust inclusion in residual carbon) as well as by the complete energetic use of recyclings through fluidized bed combustion, enables a demand oriented decentral generation of electric energy and heating energy from biomass according to the regulations of the Renewable Energy Law (EEG) not only in terms of technical procedures but also in economical terms. Due to an oxygen concentration in the gasification media the &apos;&apos;CombiPower-Plus- procedure&apos;&apos; does not only generate electric energy and heating energy but also an industrial gas with a calorific value of approximately 8 MJ/kg at O{sub 2}=50 Vol.%. Furthermore the &apos;&apos;CombiPower-Plus- process&apos;&apos; achieves an increase of the fuel performance by a magnitude of 2.5 to 3 compared to the &apos;&apos;CombiPower plant&apos;&apos; that is equal in construction. A reduction of the specific investment costs from approximately 3,750 /kW (Pel) to under 2,000 /kW (Pel) can be expected. Due to the procedure no residual materials like tar, dust or waste water are generated. In case of a further price increase of energy raw materials on the international market this process enables on the hand the use of renewable combustibles like wood, which is preferred for decentral electric current generation in Germany due to the incentive regulations of the EEG, on the other hand this process also enables the economic use of regionally available brown coal as combustible for decentral energy generation. (orig.)

  17. &apos;Advancement of KHPS to DOE TRL 7/8&apos; Project - Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Adonizio, Mary Ann [Verdant Power Inc., New York, NY (United States); Corren, Dean [Verdant Power Inc., New York, NY (United States); Smith, Ron [Verdant Power Inc., New York, NY (United States); Colby, Jonathan [Verdant Power Inc., New York, NY (United States); Hernandez, Aaron [Verdant Power Inc., New York, NY (United States)

    2016-04-08

    Final Report describing activities performed under the &apos;Advancement of the KHPS to DOE TRL 7/8&apos; project, including the development of critical component test protocols, testing and analysis of the Gen5 KHPS main shaft seal, and continuing compliance work on approved operational environmental monitoring plans in anticipation of KHPS turbine installation at Verdant Power&apos;s Roosevelt Island Tidal Energy (RITE) Project site in New York, NY.

  18. Selective suppression of adipose tissue apoE expression impacts systemic metabolic phenotype and adipose tissue inflammation.

    Science.gov (United States)

    Huang, Zhi H; Reardon, Catherine A; Getz, Godfrey S; Maeda, Nobuyo; Mazzone, Theodore

    2015-02-01

    apoE is a multi-functional protein expressed in several cell types and in several organs. It is highly expressed in adipose tissue, where it is important for modulating adipocyte lipid flux and gene expression in isolated adipocytes. In order to investigate a potential systemic role for apoE that is produced in adipose tissue, mice were generated with selective suppression of adipose tissue apoE expression and normal circulating apoE levels. These mice had less adipose tissue with smaller adipocytes containing fewer lipids, but no change in adipocyte number compared with control mice. Adipocyte TG synthesis in the presence of apoE-containing VLDL was markedly impaired. Adipocyte caveolin and leptin gene expression were reduced, but adiponectin, PGC-1, and CPT-1 gene expression were increased. Mice with selective suppression of adipose tissue apoE had lower fasting lipid, insulin, and glucose levels, and glucose and insulin tolerance tests were consistent with increased insulin sensitivity. Lipid storage in muscle, heart, and liver was significantly reduced. Adipose tissue macrophage inflammatory activation was markedly diminished with suppression of adipose tissue apoE expression. Our results establish a novel effect of adipose tissue apoE expression, distinct from circulating apoE, on systemic substrate metabolism and adipose tissue inflammatory state.

  19. Selective suppression of adipose tissue apoE expression impacts systemic metabolic phenotype and adipose tissue inflammation

    Science.gov (United States)

    Huang, Zhi H.; Reardon, Catherine A.; Getz, Godfrey S.; Maeda, Nobuyo; Mazzone, Theodore

    2015-01-01

    apoE is a multi-functional protein expressed in several cell types and in several organs. It is highly expressed in adipose tissue, where it is important for modulating adipocyte lipid flux and gene expression in isolated adipocytes. In order to investigate a potential systemic role for apoE that is produced in adipose tissue, mice were generated with selective suppression of adipose tissue apoE expression and normal circulating apoE levels. These mice had less adipose tissue with smaller adipocytes containing fewer lipids, but no change in adipocyte number compared with control mice. Adipocyte TG synthesis in the presence of apoE-containing VLDL was markedly impaired. Adipocyte caveolin and leptin gene expression were reduced, but adiponectin, PGC-1, and CPT-1 gene expression were increased. Mice with selective suppression of adipose tissue apoE had lower fasting lipid, insulin, and glucose levels, and glucose and insulin tolerance tests were consistent with increased insulin sensitivity. Lipid storage in muscle, heart, and liver was significantly reduced. Adipose tissue macrophage inflammatory activation was markedly diminished with suppression of adipose tissue apoE expression. Our results establish a novel effect of adipose tissue apoE expression, distinct from circulating apoE, on systemic substrate metabolism and adipose tissue inflammatory state. PMID:25421060

  20. Eficiência de lagoas de polimento no pós-tratamento de reator UASB no tratamento de águas residuárias de suinocultura

    Directory of Open Access Journals (Sweden)

    A.C.A. Pinto

    2014-04-01

    Full Text Available Avaliou-se o desempenho de um sistema de lagoas seriadas que recebeu efluentes de reator UASB, no tratamento de águas residuárias de suinocultura. O sistema foi composto de reator anaeróbio de chicanas (RAC, reator UASB, em escala real, e uma série de lagoas (uma lagoa facultativa e três de maturação, em escala piloto. As análises físico-químicas realizadas foram: pH, demanda bioquímica de oxigênio (DBO, demanda química de oxigênio (DQO, sólidos suspensos totais (SST, sólidos suspensos voláteis (SSV, nitrogênio amoniacal (N-am., fósforo total (Pt, coliformes totais (CT e Escherichia coli (EC. As lagoas de pós-tratamento contribuíram eficientemente para remoção de nutrientes, matéria orgânica e sólidos, fornecendo um efluente com qualidade para o reuso agrícola ou lançamento em corpos d'água.

  1. Reply to &apos;Comment on &apos;On the inconsistency of the Bohm-Gadella theory with quantum mechanics&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Madrid, Rafael de la [Department of Physics, University of California at San Diego, La Jolla, CA 92093 (United States)

    2007-04-27

    In this reply, we show that when we apply standard distribution theory to the Lippmann-Schwinger equation, the resulting spaces of test functions would comply with the Hardy axiom only if classic results of Paley and Wiener, of Gelfand and Shilov, and of the theory of ultradistributions were wrong. Also, we point out several differences between the &apos;standard method&apos; of constructing rigged Hilbert spaces in quantum mechanics and the method used in time asymmetric quantum theory. (note)

  2. Radiotherapy in Kimura&apos;s Disease

    Energy Technology Data Exchange (ETDEWEB)

    Huh, Gil Cha; Kang, Seung Hee; Suh, Hyun Suk [Inje University College of Medicine, Seoul (Korea, Republic of)

    1994-02-15

    Kimura&apos;s disease is a rare disorder which predominantly involves the head and neck region can cause eosinophilia in peripheral blood. It has been treated with steroids, surgical excision, irradiation, cryotherapy, and laser. The sessions have a tendency to recur after steroid and surgery. We reviewed 2 patients with Kimura&apos;s disease who recurred, because they were resistant steroid therapy and surgery, and treated successfully conventional radiation therapy.

  3. India&apos;s Downstream Petroleum Sector

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This study provides a holistic examination of pricing and investment dynamics in India&apos;s downstream petroleum sector. It analyses the current pricing practices, highlights the tremendous fiscal cost of current pricing and regulatory arrangements, and examines the sectoral investment dynamics. It also looks at potential paths towards market-based reform along which the Indian government may move, while at the same time protecting energy market access for India&apos;s large poor population.

  4. Imaging findings in 22 cases of Schnitzler syndrome: characteristic para-articular osteosclerosis, and the &apos;&apos;hot knees&apos;&apos; sign differential diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Niederhauser, Blake D. [Department of Radiology, Rochester, MN (United States); Dingli, David; Kyle, Robert A. [Mayo Clinic, Division of Hematology, Rochester, MN (United States); Ringler, Michael D. [Mayo Clinic, Department of Radiology, Rochester, MN (United States)

    2014-07-15

    Schnitzler syndrome is characterized by chronic urticaria, monoclonal gammopathy, and a risk of developing lymphoproliferative disorders. Patients frequently present with bone pain, fever, arthralgia, and lymphadenopathy. The purpose of this study is to retrospectively review and evaluate potentially attributable imaging abnormalities in a series of patients with clinically diagnosed Schnitzler syndrome. Clinical and pathological chart review identified 22 patients meeting Strasbourg criteria for Schnitzler syndrome. Imaging of these patients was retrospectively reviewed by a musculoskeletal radiologist and a radiology fellow to determine and characterize significant &apos;'positive'&apos; findings that could potentially be attributed to their primary disease process. Evidence of abnormal bone remodeling was present in 64 % (14/22) of patients with 40 bone abnormalities. Lesions were predominantly or entirely sclerotic and most commonly involved the distal femora (n = 11), proximal tibiae (nine), and innominate bones (six). Patterns of involvement were variable, but typically eccentrically intramedullary, cortical, and juxta-articular. Skeletal surveys and targeted radiographs identified only 37 % (10/27) of abnormal bones subsequently &apos;'positive'&apos; by additional modalities. PET and bone scans were all positive in patients with bone sclerosis (13/13 and 17/17 bone sites, respectively). Schnitzler syndrome often presents with characteristic osteosclerosis, most commonly around the knees and in the pelvis. In patients with a suggestive clinical history, the radiologist could direct an appropriate imaging strategy or might to be the first to suggest the diagnosis. Bone scan may be the most appropriate initial screening tool in suspected cases. (orig.)

  5. Transient stress analysis of the main steam isolation valve during the load case &apos;&apos;fast opening of the main steam isolation valve&apos;&apos;; Transiente Spannungsanalyse des Gehaeuses eines aeusseren Frischdampfisolierventils beim Lastfall &apos;&apos;Schnelles Oeffnen des Frischdampfisolierventils&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Pacharzina, B.; Uptmoor, H. [Westinghouse Electric Germany GmbH, Mannheim (Germany)

    2008-07-01

    The structural integrity was demonstrated for a German NPP including the load case &apos;&apos;fast opening of the main steam isolation valve&apos;&apos;. Since the verification of the armature housing integrity was not possible using the component specific method according KTA 3201.2 a detailed finite element analysis using the ANSYS-FE code and elastic material characteristics was performed. The considered loads include operating weight, internal pressure, restrained thermal expansion, and fluid dynamical loads. For the damping behavior according KTA 2201.4 (earth quakes) a damping factor of 4% of the critical damping was assumed. The stress analysis was performed and evaluated.

  6. German Bundestag: New enquiry commission. &apos;&apos;Sustainable energy supply in times of globalisation and deregulation&apos;&apos;; Deutscher Bundestag: neue Enquete-Kommission. Ziel: &apos;&apos;Nachhaltige Energieversorgung unter den Bedingungen der Globalisierung und der Liberalisierung&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Schafhausen, F. [Bundesministerium fuer Umwelt, Naturschutz und Reaktorsicherheit, Berlin (Germany)

    2000-08-01

    The new enquiry commission was authorized by the German Bundestag on 24 March 2000. It consists of 13 parliament members and 13 scientists and will investigate the issue of sustainable energy supply. The German Bundestag thus takes account of the current discussion on the characteristics and details of sustainable energy supply. [German] Am 24. Maerz 2000 setzte der Deutsche Bundestag eine neue Euquete-Kommission ein. Diese besteht aus 13 Mitgliedern des Parlaments und 13 Wissenschaftlern und soll sich dem Thema &apos;Nachhaltige Energieversorgung&apos; widmen. Damit zog der Deutsche Bundestag die Konsequenz aus der mittlerweile stattfindenden Diskussion ueber die Kennzeichen und Ausgestaltung einer &apos;nachhaltigen Energieversorgung&apos;. (orig.)

  7. The &apos;&apos;smart consumer&apos;&apos;. Consequences and future challenges from the modified customer role for the established energy supplier; Der &apos;&apos;smarte Verbraucher&apos;&apos;. Konsequenzen und kuenftige Herausforderungen aus der veraenderten Kundenrolle fuer die etablierten Energieversorger

    Energy Technology Data Exchange (ETDEWEB)

    Hense, Andreas [Capgemini Consulting, Koeln (Germany)

    2011-07-01

    Growing decentral generation, digitalization of the whole utilities sector and smart technologies are changing the role fo the &apos;'utilities'&apos; customers. From pure end consumers they will more and more shift to energy-conscious, demanding market players acting as well as producers of energy. This breaks the traditional value chain. In order to participate on the business chances of this development utilities have to build up new, innovative business models around the smart customer. Sustainable success of these approaches depends on some key requirements. (orig.)

  8. &apos;Fullerines&apos;: From curiosity to high-technology materials

    Energy Technology Data Exchange (ETDEWEB)

    Malatesta, L. (Milan Univ. (Italy))

    1992-01-01

    The discovery of the so-called &apos;fullerines&apos;, i.e., carbon atom clusters forming closed structures, hollow within, and having an even number of sides ranging from 24 to 540, represents an interesting novelty in chemical engineering materials research. These substances are important in that they constitute a third allotropic form of carbon, exhibiting stable thermodynamic and kinetic behaviour as compared with graphite and diamond respectively. This paper focusses attention on the properties and possible applications of the C/sub 60/ and C/sub 70/ &apos;fullerines&apos; thus named due to their Buckminster Fuller type geodetic structural forms.

  9. Effect of Diet and Age on Arterial Stiffening Due to Atherosclerosis in ApoE(-/-) Mice.

    Science.gov (United States)

    Cilla, M; Pérez, M M; Peña, E; Martínez, M A

    2016-07-01

    This work analyzes the progressive stiffening of the aorta due to atherosclerosis development of both ApoE(-/-) and C57BL/6J mice fed on a Western (n = 5) and a normal (n = 5) chow diet for the ApoE(-/-) group and on a normal chow diet (n = 5) for the C57BL/6J group. Sets of 5 animals from the three groups were killed after 10, 20, 30 and 40 weeks on their respective diets (corresponding to 17, 27, 37 and 47 weeks of age). Mechanical properties (inflation test and axial residual stress measurements) and histological properties were compared for both strains, ApoE(-/-) on the hyper-lipidic diet and both ApoE(-/-) and C57BL/6J on the normal diet, after the same period and after different periods of diet. The results indicated that the aorta stiffness in the ApoE(-/-) and C57BL/6J mice under normal diet remained approximately constant irrespective of their age. However, the arterial stiffness in the ApoE(-/-) on the hyper-lipidic diet increased over time. Statistical differences were found between the group after 10 weeks and the groups after 30 and 40 weeks of a hyper-lipidic diet. Comparing the hyper-lipidic and normal diet mice, statistical differences were also found between both diets in all cases after 40 weeks of diet, frequently after 30 weeks, and in some cases after 20 weeks. The early stages of lesion corresponded to the first 2 weeks of diet. Advanced lesions were found at 30 weeks and, finally, the aorta was completely damaged after 40 weeks of diet. In conclusion, we found substantial changes in the mechanical properties of the aorta walls of the ApoE(-/-) mice fed with the hyper-lipidic diet compared to the normal chow diet groups for both the ApoE(-/-) and C57BL/6J groups. These findings could serve as a reference for the study of changes in the arterial wall properties in cases of atherosclerosis.

  10. Comportamento da eosinofilia após o tratamento das geohelmintoses

    Directory of Open Access Journals (Sweden)

    Marta Maria Bozóti

    1973-04-01

    Full Text Available A eosinofilia sanguínea após o tratamento anti-helmíntico específico se comportou numa amostragem de 57 crianças da seguinte forma: .Na ascaridíase isolada ou associada à trieuríase a hipereosinofilia parasitária ou descia uniformemente após o tratamento, ou houve primeiro uma exacerbação que durava até a terceira semana após a erradicação da, parasitose, descendo em seguida. Em ambos os casos houve normalização do hemograma em dois meses. Na associação ascaridíase/ancilostomíase também são possíveis dois tipos de comportamento da eosinofilia após tratamento eficaz: ou vai diminuindo a hipereosinofilia, logo em seguida à expulsão dos parasitos, ou há no primeiro mês um aumento da hipereosinofilia (geralmente mais acentuado na primeira semana que se segue ao tratamento, para diminuir após o fim do primeiro mês progressivamente até desaparecer. Na estrongiloidíase e na associação ascaridíase/estrongiloidíase há diminuição constante da hipereosinofilia logo após o tratamento e o hemograma se normaliza em cerca de dois meses. Na trieuríase, a hipereosinofilia, aliás já discreta, diminui pouco com o tratamento. Na ancilostomíase e na associação ancilostomíase/trieuríase a hipereosinofilia ou desce após o tratamento gradativo e lentamente, ou primeiro há uma exaltação temporária nas primeiras três semanas após a terapêutica, para diminuir em seguida. Na associação ancilostomíase/estrongiloidíase também se encontram esses dois tipos de comportamento da hipereosinofilia verminótica, mas a exacerbação da hipereosinofilia, que ocorre na metade dos casos, só dura duas semanas; a regressão eosinofílica ocorre dois meses após o tratamento. Nas tri e tetraeparasitoses a involução pós-terapêutica da hipereosinofilia é irregular e a normalização das taxas sanguíneas de eosinófilos é sempre arrastada, principalmente nas associações ascaridíase/estrongiloidíase/ancilostomíase e

  11. Oficinas de espiritualidade: alternativa de cuidado para o tratamento integral de dependentes químicos

    Directory of Open Access Journals (Sweden)

    Dirce Stein Backes

    2012-10-01

    Full Text Available Trata-se de um relato de experiência vivenciada com usuários de crack sob tratamento de desintoxicação, na qual se buscou alcançar o cuidado integral ao ser humano por meio de oficinas de espiritualidade. Cultivadas e dinamizadas a partir de inspirações dos próprios integrantes, as oficinas se constituem em estratégias capazes de estimular o repensar de atitudes e comportamentos, bem como reassumir a vida com base em novos valores e ideais. O relato visa, em suma, contribuir para a ampliação das discussões sobre o tema, oferecendo subsídios para o repensar da prática do enfermeiro no tratamento de desintoxicação, além de assinalar a necessidade de condução de pesquisas nessa área.

  12. Utilização de insulina para tratamento de diabetes no Brasil

    OpenAIRE

    Vieira, Pedro Felipe Couto

    2016-01-01

    O tratamento da Diabetes Mellitus (DM) é complexo e um dos seus objetivos centrais é a obtenção de valores glicêmicos o mais próximo da normalidade. Seu tratamento pode ou não estar associado à prescrição de medicamentos ou à reposição insulínica. No Brasil, segundo a Pesquisa Nacional de Saúde (PNS) 2013, estima-se uma prevalência de diabetes de 6,2%, atingindo 9 milhões de brasileiros. O presente estudo teve por objetivo descrever a prevalência de diabetes, indicação médica e utilização de ...

  13. Experiências com o Antihelmíntico BB-04 no tratamento de helmintoses intestinais

    Directory of Open Access Journals (Sweden)

    Léa Camillo-Coura

    1971-04-01

    Full Text Available Os autores apresentam os resultados da associação piperazina-tiabendazol-dimetilpolisiloxane no tratamento de infecções por helmintos intestinais. Os resultados vieram confirmar a apreciável eficácia da piperazina e do tiabendazol para o tratamento da ascaridíase e da ancilostomíase nas doses utilizadas. Houve cura de 50% dos 82 casos de ancilostomíase, de 41% dos 72 de ascaridiase e de 26% dos 76 portadores de infecção pelo Trichuris trichiura. Observou-se regressão da sintomatologia na maioria dos casos após instituída a terapêutica, especialmente dor abdominal, diarréia e obstipação. A tolerância ao medicamento foi considerada boa.

  14. Uso do octreotide no tratamento do quilotórax e quiloperitôneo

    Directory of Open Access Journals (Sweden)

    Cristiane Felix Ximenes Pessotti

    2011-08-01

    Full Text Available Relato de três casos de quilotórax e um caso de ascite quilosa em crianças em pós-operatório de cirurgia cardíaca, que evoluíram sem resposta ao tratamento clínico habitual, baseado em jejum e nutrição parenteral prolongada. Tratamento com octreotide na dose inicial de 1,0 mcg/kg/h foi escolhido, com aumento progressivo de 1,0 mcg/kg/h/dia até a dose máxima de 4,0 mcg/kg/h. Todos os casos tiveram resposta favorável, com redução progressiva do débito do dreno, até resolução do quadro, sem efeito colateral significativo.

  15. Tratamento das escaras de decúbito com própolis

    Directory of Open Access Journals (Sweden)

    Ivete Borsaro Soares de Azevedo

    1986-09-01

    Full Text Available No presente trabalho, as autoras avaliam o uso do método natural da Própolis concentrada a 3% (resina das plantas colhidas pelas abelhas passada pelo processo de digestão das mesmas liberando assim inúmeras enzimas enriquecendo o produto, em tratamento das escaras de decúbito. O trabalho consiste em: a Preparar as escaras de decúbito para que, em tempo mais reduzido, sejam feitas as correções cirúrgicas e/ou curá-las em definitivo; b Avaliar o poder bactericida e bacteriostatico da Própolis. Deve-se ressaltar que o medicamento ativou consideravelmente a regeneração dos tecidos, reduzindo o tempo e o custo usuais para tratamento clássico das escaras de decúbito.

  16. Tratamento cirúrgico da siringomielia pela Técnica de Gardner

    Directory of Open Access Journals (Sweden)

    Gilberto M. Almeida

    1973-12-01

    Full Text Available O tratamento cirúrgico da siringomielia é, em geral, considerado decepcionante. Vários tipos de drenagem da cavidade siringomiélica não têm fornecido resultados satisfatórios. Gardner, em magnífica série de trabalhos, mostrou que a siringomielia e as várias malformações associadas à hidrocefalia têm fisiopatogenia única. Baseado em sua teoria, Gardner propôs, em 1958, o bloqueio da comunicação entre o IV ventrículo e o canal central da medula, para o tratamento da siringomielia. Esta técnica não tem sido realizada com muita freqüência. Empregamos o método proposto por Gardner em 4 pacientes, os quais melhoraram após a intervenção cirúrgica.

  17. Psicoterapia interpessoal no tratamento da perturbação depressiva maior

    Directory of Open Access Journals (Sweden)

    Catarina Oliveira Lucas

    2012-08-01

    Full Text Available A terapia interpessoal é um modelo de terapia breve formulado para o tratamento da perturbação depressiva maior, tendo como precursores Gerald Klerman e Mirna Weissman. Esta visa o alívio dos sintomas associados à depressão abordando os problemas interpessoais que os originaram e perpetuam. Esta modalidade de terapia refere as perturbações como resultantes da existência de problemas numa das quatro áreas interpessoais principais: luto, transição de papéis, disputas de papéis interpessoais e défices interpessoais. Deste modo, a terapia incidirá na área afectada. Esta demonstra bons indicadores de eficácia e apesar de formulada para o tratamento da depressão, a terapia interpessoal tem sido adaptada e expandida a outras perturbações.

  18. Os objetos e o tratamento da criança autista

    Directory of Open Access Journals (Sweden)

    Ariana Lucero

    2015-12-01

    Full Text Available Resumo O objetivo deste artigo é refletir sobre o uso dos objetos na direção de tratamento psicanalítico da criança autista. Primeiramente, teceremos algumas considerações a respeito da importância do objeto na constituição subjetiva, a partir da oposição freudiana entre os princípios de prazer e de realidade. A seguir, retomaremos as considerações de Frances Tustin sobre o objeto autístico e o caso Joey, de Bruno Bettelheim, para exemplificarmos como autores clássicos da psicanálise teorizaram sobre o objeto no tratamento. Por fim, discutiremos com autores contemporâneos a importância de uma retomada da noção de objeto no âmbito da teoria e da prática psicanalíticas.

  19. Efeito adverso do uso intermitente de rifampicina para tratamento de hanseníase

    Directory of Open Access Journals (Sweden)

    Priscila Maria de Oliveira Papaiordanou

    1988-10-01

    Full Text Available Os autores apresentam um caso de insuficiência renal aguda, hemólise aguda e trombocitopenia relacionada ao uso intermitente de Rifampicina para tratamento da Hanseníase. Estas reações adversas são observadas com extrema raridade na literatura mundial. A evolução da paciente foi benigna havendo recuperação total da função renal e regressão completa das alterações hematológicas. Este foi o primeiro registro no Brasil dos efeitos adversos da Rifampicina no tratamento de Hanseníase. São discutidos os principais aspectos patogênicos das alterações apresentadas e fez-se revisão da literatura existente sobre o assunto.

  20. Persistent organochlorine pollutants and risk for skeletal fractures and impaired bone mineral density in humans. Results from the &apos;'COMPARE'&apos; project

    Energy Technology Data Exchange (ETDEWEB)

    Hagmar, L.; Wallin, E.; Joensson, B.A. [Department of Occupational and Environmental Medicine, Lund (Sweden)

    2004-09-15

    Persistent organochlorine pollutants (POP) have, in animal studies, impaired normal bone metabolism and resulted in increased bone fragility. Especially considering the dramatical increase in osteoporotic fractures in western societies during the last decades, it is a pertinent question whether a high dietary intake of POP might pose a risk for deteriorated bone quality in humans. This problem has been assessed as a part of the collaborative project &apos;'COMPARE'&apos;, funded by European Commission RD Life Science Program. As a study base we have used cohorts of Swedish fishermen&apos;s families. We have earlier shown that fishermen living at the east coast of Sweden, have a high consumption of contaminated fatty fish from the Baltic Sea and consequently relatively high exposure levels for various POPs, also compared with fishermen from the Swedish west coast. Such a discrepancy was also found for fishermen&apos;s wives. The aim of the project was to assess in epidemiological studies whether a high dietary intake of POP through fatty fish from the Baltic may result in an increased incidence of osteoporotic fractures or decreased bone mineral density (BMD). We give here an overview of the results.