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  1. Adenovirus-mediated sphingomyelin synthase 2 increases atherosclerotic lesions in ApoE KO mice

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    Zhao Yarui

    2011-01-01

    Full Text Available Abstract Background Sphingomyelin synthase 2 (SMS2 contributes to de novo sphingomyelin (SM biosynthesis. Its activity is related to SM levels in the plasma and the cell membrane. In this study, we investigated the possibility of a direct relationship between SMS and atherosclerosis. Methods The Adenovirus containing SMS2 gene was given into 10-week ApoE KO C57BL/6J mice by femoral intravenous injection. In the control group, the Adenovirus containing GFP was given. To confirm this model, we took both mRNA level examination (RT-PCR and protein level examination (SMS activity assay. Result We generated recombinant adenovirus vectors containing either human SMS2 cDNA (AdV-SMS2 or GFP cDNA (AdV-GFP. On day six after intravenous infusion of 2 × 1011 particle numbers into ten-week-old apoE KO mice, AdV-SMS2 treatment significantly increased liver SMS2 mRNA levels and SMS activity (by 2.7-fold, 2.3-fold, p Conclusions Our results present direct morphological evidence for the pro-atherogenic capabilities of SMS2. SMS2 could be a potential target for treating atherosclerosis.

  2. Insulin Resistance Promotes Early Atherosclerosis via Increased Proinflammatory Proteins and Oxidative Stress in Fructose-Fed ApoE-KO Mice

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    Beatriz Cannizzo

    2012-01-01

    Mice were fed with either a normal chow or a 10% w/v fructose (HF in drinking water over a period of 8 weeks. Thereafter, plasma metabolic parameters, vascular remodeling, atheroma lesion size, inflammatory markers, and NAD(PH oxidase activity in the arteries were determined. HF diet induced a marked increase in plasma glucose, insulin, and triglycerides in ApoE-KO mice, provoked vascular remodeling, enhanced expression of vascular cell-adhesion molecule-1 (VCAM-1 and matrix metalloprotease 9 (MMP-9 and enlarged atherosclerotic lesion in aortic and carotid arteries. NAD(PH oxidase activity was enhanced by fructose intake, and this effect was attenuated by tempol, a superoxide dismutase mimetic, and losartan, an Angiotensin II receptor antagonist. Our study results show that high-fructose-induced insulin resistance promotes a proinflammatory and prooxidant state which accelerates atherosclerotic plaque formation in ApoE-KO mice.

  3. Karyotype analysis of a male exhibiting Meckel's diverticulum and aural atresia

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    Frizzell, B.; Hicks, M.F. (David Lipscomb Univ., Nashville, TN (United States))

    Patau's Syndrome is caused by inheritance of an extra chromosome 13. It is characterized primarily by severe mental retardation, cleft palate, and retarded growth. Most fetuses expressing Patau's Syndrome spontaneously abort, and those that are born usually die before one year. Both Meckel's diverticulum and aural atresia are defects found in patients with Patau's at levels higher than those in the general population. An otherwise asymptomatic male expressing only Meckel's diverticulum and aural atresia has a female sibling whose son expressed Patau's syndrome. Twenty percent of patients with Patau's show a translocation of part of chromosome 13 to another D chromosome. If a translocation were the cause of the expression of Patau's in this family, it is possible that the normal male inherited a balanced translocation and the Patau's male received an unbalanced translocation. A karyotype analysis of the non-Patau's male was done to determine if such a translocation were present.

  4. Notes on the Diet of Reproductively Active Male Rafinesque's Big Eared Bats

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    Menzel, M.A.; Carter, T.C.; Menzel, J.M.; Edwards, J.W.; Ford, W.M.

    2002-01-01

    Diet examination through the use of fecal samples, of five reproductively active male Rafinesque's big-eared bats from the Upper Coastal Plain of South Carolina during August and September 1999. Diets of these individuals in upland pine stands were similar to diets of Rafinesque's big-eared bats in bottomland and upland hardwood habitats. Although fecal samples had three insect orders, the diet consisted primarily of lepidopterans.

  5. "But I'm Oppressed Too": White Male College Students Framing Racial Emotions as Facts and Recreating Racism

    Science.gov (United States)

    Cabrera, Nolan L.

    2014-01-01

    Most analyses of racism focus on what people think about issues of race and how this relates to racial stratification. This research applies Feagin's "white racial frame" to analyze how White male college students at two universities "feel" about racism. Students at the academically non-selective and less diverse…

  6. Four-Year-Olds' Beliefs about How Others Regard Males and Females

    Science.gov (United States)

    Halim, May Ling; Ruble, Diane N.; Tamis-LeMonda, Catherine S.

    2013-01-01

    Children's awareness of how others evaluate their gender could influence their behaviours and well-being, yet little is known about when this awareness develops and what influences its emergence. The current study investigated culturally diverse 4-year-olds' ("N" = 240) public regard for gender groups and whether exposure to…

  7. "I 'See' Trayvon Martin": What Teachers Can Learn from the Tragic Death of a Young Black Male

    Science.gov (United States)

    Love, Bettina L.

    2014-01-01

    The goal of this article is to examine the racially hostile environment of U.S. public schooling towards Black males. Drawing on the work of Foucault ("Discipline and punish. The birth of the prison," Penguin Books, London, 1977; "Michel Foucault: beyond structuralism and hermeneutics," The Harvester Press, Brighton, 1982)…

  8. Differentiation in boron distribution in adult male and female rats' normal brain: A BNCT approach

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    Goodarzi, Samereh, E-mail: samere.g@gmail.com [Department of Nuclear Engineering, Science and Research Branch, Islamic Azad University, PO Box 19395-1943, Tehran (Iran, Islamic Republic of); Pazirandeh, Ali, E-mail: paziran@yahoo.com [Department of Nuclear Engineering, Science and Research Branch, Islamic Azad University, PO Box 19395-1943, Tehran (Iran, Islamic Republic of); Jameie, Seyed Behnamedin, E-mail: behnamjameie@tums.ac.ir [Basic Science Department, Faculty of Allied Medicine, Tehran University of Medical Sciences, Tehran (Iran, Islamic Republic of); Department of Anatomy, Faculty of Medicine, Tehran University of Medical Sciences, Tehran (Iran, Islamic Republic of); Baghban Khojasteh, Nasrin, E-mail: khojasteh_n@yahoo.com [Department of Nuclear Engineering, Science and Research Branch, Islamic Azad University, PO Box 19395-1943, Tehran (Iran, Islamic Republic of)

    2012-06-15

    Boron distribution in adult male and female rats' normal brain after boron carrier injection (0.005 g Boric Acid+0.005 g Borax+10 ml distilled water, pH: 7.4) was studied in this research. Coronal sections of control and trial animal tissue samples were irradiated with thermal neutrons. Using alpha autoradiography, significant differences in boron concentration were seen in forebrain, midbrain and hindbrain sections of male and female animal groups with the highest value, four hours after boron compound injection. - Highlights: Black-Right-Pointing-Pointer Boron distribution in male and female rats' normal brain was studied in this research. Black-Right-Pointing-Pointer Coronal sections of animal tissue samples were irradiated with thermal neutrons. Black-Right-Pointing-Pointer Alpha and Lithium tracks were counted using alpha autoradiography. Black-Right-Pointing-Pointer Different boron concentration was seen in brain sections of male and female rats. Black-Right-Pointing-Pointer The highest boron concentration was seen in 4 h after boron compound injection.

  9. A Small-Scale Comparison of the Relative Impact of Dialogic and Shared Book Reading with an Adult Male on Boys' Literacy Skills

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    Pillinger, Claire; Wood, Clare

    2013-01-01

    Dialogic Reading (DR) is a form of interactive shared book reading which promotes children's active participation in reading. Previous studies have demonstrated that DR positively affects young children's literacy development. This small-scale study extends existing DR research to all-male dyads to examine whether DR has a greater impact…

  10. The Problem of Privilege: Male Social Work Students' Preservice Experiences

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    Giesler, Mark A.

    2013-01-01

    Male social work students are a numerical minority in Bachelor of Social Work (BSW) programs, a reality that warrants exploration as the academy strives for greater diversity within preservice social work programs. The present qualitative phenomenological study examined how male social work students in one BSW university program perceived their…

  11. Emotions or Science? Pre-Tertiary Males' Accounts of Psychology as a Subject Choice

    Science.gov (United States)

    Mercer, Jenny; Sander, Paul; Williams, Stella; Jones, Tim

    2013-01-01

    It is well established that the number of males studying psychology in the UK, both at A-level and on degree courses, is disproportionately low compared to females. There is a paucity of research, however, which discusses how psychology is viewed by this group. The present study employed focus groups with 35 pre-tertiary males (some of whom were…

  12. Sexual Encounters: Gay Male College Students' Use of the Internet and Social Media

    Science.gov (United States)

    Reddick, Rinardo Lamon

    2012-01-01

    There have been many studies that focus on understanding various aspects of human sexuality and how it relates to college students. However, the current research focuses on heterosexual students, leaving a void in the research that focuses on gay male college students. Even more crucially, there is a void in research that focuses on the sexual…

  13. Casanovas are liars: behavioral syndromes, sperm competition risk, and the evolution of deceptive male mating behavior in live-bearing fishes [v2; ref status: indexed, http://f1000r.es/1ko

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    David Bierbach

    2013-08-01

    Full Text Available Male reproductive biology can by characterized through competition over mates as well as mate choice. Multiple mating and male mate choice copying, especially in internally fertilizing species, set the stage for increased sperm competition, i.e., sperm of two or more males can compete for fertilization of the female’s ova. In the internally fertilizing fish Poecilia mexicana, males respond to the presence of rivals with reduced expression of mating preferences (audience effect, thereby lowering the risk of by-standing rivals copying their mate choice. Also, males interact initially more with a non-preferred female when observed by a rival, which has been interpreted in previous studies as a strategy to mislead rivals, again reducing sperm competition risk (SCR. Nevertheless, species might differ consistently in their expression of aggressive and reproductive behaviors, possibly due to varying levels of SCR. In the current study, we present a unique data set comprising ten poeciliid species (in two cases including multiple populations and ask whether species can be characterized through consistent differences in the expression of aggression, sexual activity and changes in mate choice under increased SCR. We found consistent species-specific differences in aggressive behavior, sexual activity as well as in the level of misleading behavior, while decreased preference expression under increased SCR was a general feature of all but one species examined. Furthermore, mean sexual activity correlated positively with the occurrence of potentially misleading behavior. An alternative explanation for audience effects would be that males attempt to avoid aggressive encounters, which would predict stronger audience effects in more aggressive species. We demonstrate a positive correlation between mean aggressiveness and sexual activity (suggesting a hormonal link as a mechanistic explanation, but did not detect a correlation between aggressiveness and

  14. Exercise and the Prevention of Oesophageal Cancer (EPOC) study protocol: a randomized controlled trial of exercise versus stretching in males with Barrett's oesophagus

    International Nuclear Information System (INIS)

    Chronic gastro-oesophageal reflux disease and excessive body fat are considered principal causes of Barrett's oesophagus (a metaplastic change in the cells lining the oesophagus) and its neoplastic progression, oesophageal adenocarcinoma. Metabolic disturbances including altered levels of obesity-related cytokines, chronic inflammation and insulin resistance have also been associated with oesophageal cancer development, especially in males. Physical activity may have the potential to abrogate metabolic disturbances in males with Barrett's oesophagus and elicit beneficial reductions in body fat and gastro-oesophageal reflux symptoms. Thus, exercise may be an effective intervention in reducing oesophageal adenocarcinoma risk. However, to date this hypothesis remains untested. The 'Exercise and the Prevention of Oesophageal Cancer Study' will determine whether 24 weeks of exercise training will lead to alterations in risk factors or biomarkers for oesophageal adenocarcinoma in males with Barrett's oesophagus. Our primary outcomes are serum concentrations of leptin, adiponectin, tumour necrosis factor-alpha, C-reactive protein and interleukin-6 as well as insulin resistance. Body composition, gastro-oesophageal reflux disease symptoms, cardiovascular fitness and muscular strength will also be assessed as secondary outcomes. A randomized controlled trial of 80 overweight or obese, inactive males with Barrett's oesophagus will be conducted in Brisbane, Australia. Participants will be randomized to an intervention arm (60 minutes of moderate-intensity aerobic and resistance training, five days per week) or a control arm (45 minutes of stretching, five days per week) for 24 weeks. Primary and secondary endpoints will be measured at baseline (week 0), midpoint (week 12) and at the end of the intervention (week 24). Due to the increasing incidence and very high mortality associated with oesophageal adenocarcinoma, interventions effective in

  15. Starenje kože lica

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    Sjerobabski-Masnec, Ines; Šitum, Mirna

    2010-01-01

    Starenje kože je degenerativni proces koji uz kožu zahvaća i potporne strukture kože. Mlado lice je konveksno s punim usnama i obrazima, a linija mandibule je uzdignuta prema obrazima. Lice koje pokazuje znakove starenja obilježavaju tanke usne, nejednolikosti pigmentacije, opušteni obrazi i čelo, opuštena mandibula i cijelo lice se doima konkavnim. Starenje uzrokovano genskim nasljeđem i koje ovisi o prolasku vremena zovemo kronološkim starenjem ili intrinzičnim starenjem. Ono je obilježeno ...

  16. MHD mesta Košice

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    Pavúková, Marianna

    2009-01-01

    The aim of this bachelor thesis is to analyze the present condition of municipal transportation system of Košice, point out to the problems and planned solutions. In the first theoretical part there is history of public transportation in the world, basic terms and the importance of the integrated transport systems. The second practical part describes characteristic of Košice city, condition of the public transportation and future plans for building the integrated transport system in Košice.

  17. The effects of prenatal sound stress on the spatial learning and memory of rat's male offspring

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    Barzegar M

    2011-01-01

    Full Text Available "n 800x600 Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} Background: Numerous evidences indicate that various environmental stresses during pregnancy affect physiological behavior of the offspring. This experimental study was designed to investigate the effect of noise stress during prenatal period of rats on spatial learning and memory and plasma corticostrone level in postnatal life."n"nMethods: Three groups of pregnant rats were given daily noise stress with durations of two and/ or four hours in last week of pregnancy period. The fourth group was left unstressed. The male offspring from the unstressed and different stressed groups were assigned as controls and stressed groups. The animals were introduced to a spatial task in Morris water maze 4 trials/day for five consecutive days. The probe test was performed on the 5th day of the experiment. The delay in findings and the distance passed to locate the target platform were assessed as the spatial learning. "n"nResults: Our results showed that prenatal exposure to noise stress for two and/ or four hours a day, leads to impaired acquisition of spatial learning in the postnatal animals. The plasma level of corticostrone in the two stressed groups of rats markedly matched with their behavioral function. Prenatal exposure to 1- hour noise stress revealed no effects on the offsprings' behavior and plasma corticostrone level."n"nConclusion: Based on our study results, it seems that applied range of stress which is executed through the noise stress could increase the plasma corticostrone level and

  18. But We're Not Laughing: White Male College Students' Racial Joking and What This Says about "Post-Racial" Discourse

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    Cabrera, Nolan L.

    2014-01-01

    This study critically analyzes White male college student narratives regarding racial joking. Through semi-structured interviews, 29 participants described a pattern of behavior and rationalization: they heard and told racist jokes frequently; the jokes were framed as not racist; and the jokes were told only among White people, because the…

  19. Teachers' Perceptions of the Ethical Leadership of Male and Female Headteachers in Ghanaian Basic Schools

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    Agezo, Clement Kwadzo

    2013-01-01

    The lack of ethical leadership is a pervading factor in today's society. Although interest in ethical leadership has increased dramatically in Ghana as a result of the June 4 revolution by the military that preached probity, accountability, and integrity, ethics within the context of leadership has not been a subject of much discourse. Being…

  20. Increased Susceptibility of Radiation-Induced Intestinal Apoptosis in SMP30 KO Mice

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    Moon-Jung Goo

    2013-05-01

    Full Text Available Recently, senescence marker protein-30 (SMP30 knockout (KO mice have been reported to be susceptible to apoptosis, however, the role of SMP30 has not been characterized in the small intestine. The aim of the present study is to investigate the role of SMP30 in the process of spontaneous and γ-radiation-induced apoptosis in mouse small intestine. Eight-week-old male wild-type (WT mice and SMP30 KO mice were examined after exposure to 0, 1, 3, 5, and 9 Gy of γ-radiation. Apoptosis in the crypts of the small intestine increased in the 0 to 5 Gy radiated SMP30 KO and WT mice. Radiation-induced apoptosis and the BAX/Bcl-2 ratio in the SMP30 KO mice were significantly increased in comparison to each identically treated group of WT mice (p 0.05, indicating that increased apoptosis of crypt cells of SMP30 KO by irradiation can be associated with SMP30 depletion. These results suggested that SMP30 might be involved in overriding the apoptotic homeostatic mechanism in response to DNA damage.

  1. Exercise training and antioxidant supplementation independently improve cognitive function in adult male and female GFAP-APOE mice

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    Kiran Chaudhari

    2014-09-01

    Conclusion: Exercise was the most effective treatment at improving cognitive function in both genotypes and sex, while antioxidants seemed to be effective only in the APOE4. In young adult mice only non-spatial learning and memory were improved. The combination of the two treatments did not yield further improvement in cognition, and there was no antagonistic action of the antioxidant supplementation on the beneficial effects of exercise.

  2. Home Range and Habitat Use of Male Rafinesque's Big-Eared Bats (Corynorhinus rafinesquii)

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    Menzel, M.A.; Menzel, J.M.; Ford, W.M.; Edwards, J.W.; Carter, T.C.; Churchill, J.B.; Kilgo, J.C.

    2000-03-13

    We examined home range size and habitat use of four reproductively active male Rafinesque Big-eared bats in the upper Coastal Plain of South Carolina during August and September of 1999. Most foraging activity occurred during the first 4 hours after sunset and the first two hours before sunrise. Mean home range size was 93.1 hectares. Most foraging activity occurred in young pines even though large tracks of bottomland hardwood were available. Only 9% of foraging occurred in bottomland hardwoods.

  3. Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO mice.

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    Jingbo Pang

    Full Text Available Obesity and type 2 diabetes are associated with increased production of Galectin-3 (Gal-3, a protein that modulates inflammation and clearance of glucose adducts. We used Lean and Diet-induced Obese (DIO WT and Gal-3 KO mice to investigate the role of Gal-3 in modulation of adiposity, glucose metabolism and inflammation. Deficiency of Gal-3 lead to age-dependent development of excess adiposity and systemic inflammation, as indicated by elevated production of acute-phase proteins, number of circulating pro-inflammatory Ly6C(high monocytes and development of neutrophilia, microcytic anemia and thrombocytosis in 20-week-old Lean and DIO male Gal-3 KO mice. This was associated with impaired fasting glucose, heightened response to a glucose tolerance test and reduced adipose tissue expression of adiponectin, Gal-12, ATGL and PPARγ, in the presence of maintained insulin sensitivity and hepatic expression of gluconeogenic enzymes in 20-week-old Gal-3 KO mice compared to their diet-matched WT controls. Expression of PGC-1α and FGF-21 in the liver of Lean Gal-3 KO mice was comparable to that observed in DIO animals. Impaired fasting glucose and altered responsiveness to a glucose load preceded development of excess adiposity and systemic inflammation, as demonstrated in 12-week-old Gal-3 KO mice. Finally, a role for the microflora in mediating the fasting hyperglycemia, but not the excessive response to a glucose load, of 12-week-old Gal-3 KO mice was demonstrated by administration of antibiotics. In conclusion, Gal-3 is an important modulator of glucose metabolism, adiposity and inflammation.

  4. Rooting "Ko-ko-ro" into the Brain: Toward the Neuroanatomy of Mind

    OpenAIRE

    Mori, Nozomu

    2005-01-01

    "Ko-ko-ro", meaning 'mind', is a complex higher order function of the human brain. The two distinct activities of mind that are best understood are the ability to recognize oneself, i.e., self-awareness, and the ability to read another mind. These two functions form the fundamental basis of humanity, thereby allowing us to conform and live in harmony within a given family, community, or society. The mind is formed under certain conditions within neural systems in the human brain, and potentia...

  5. VRSTE VPISOV V ZEMLJIŠKO KNJIGO

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    Rožec, Polona

    2015-01-01

    Zemljiška knjiga je javna knjiga, ki je namenjena vpisu in objavi podatkov o pravicah na nepremičninah in pravnih dejstvih v zvezi z nepremičninami. Sestavljena je iz glavne knjige ter zbirke listin. Glavna knjiga je namenjena vpisu podatkov o pravicah na nepremičninah, kot tudi vpisu pravnih dejstev v zvezi z nepremičninami, za katere zakon določa, da se vpišejo v zemljiško knjigo. Zbirko listin pa tvorijo listine, ki so bile podlaga za opravljen vpis v glavno knjigo. Samo popolna zemlji...

  6. Ethanol production by Escherichia coli KO11; Producao de etanol por Escherichia coli KO11

    Energy Technology Data Exchange (ETDEWEB)

    Lima, Katia Gianni de Carvalho [Sao Paulo Univ., SP (Brazil). Faculdade de Ciencias Farmaceuticas. Lab. de Microbiologia de Alimentos]. E-mail: gianni@usp.br; Takahashi, Caroline Maki; Alterthum, Flavio [Sao Paulo Univ., SP (Brazil). Inst. de Ciencias Biomedicas. Dept. de Microbiologia

    2002-08-01

    This paper discusses the potential use of Escherichia coli KO11 in production of ethanol, based on observation that this organism can efficiently metabolize sugar complex moistures obtained from the acid hydrolysis of lignocellulose materials such as sugar-cane bagasse, corncob, corn husk, Pinus sp and oak wood.

  7. Relationships between men's gender attitudes and fertility: Response to Puur et al.'s "Men's childbearing desires and views of the male role in Europe at the dawn of the 21st century"

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    Charles Westoff

    2009-07-01

    Full Text Available An analysis published in a recent edition of this journal (Puur, Olah, Tazi-Preve, and Dorbritz 2008 reported that, in eight European countries, men with egalitarian gender attitudes both desired and had more children than men with more traditional gender attitudes. These unexpected findings led us to explore a similar research question with an alternate dataset--the European/World Value Surveys. But we found--without exception--a negative association between men's egalitarian attitudes and fertility, not only in the selected eight European countries but also in a considerable number of other developed countries. We explore possible reasons for and implications of these divergent findings.

  8. Contact karst of Kočevski Rog and Kočevska Mala gora

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    Petra Gostinčar

    2011-12-01

    Full Text Available On high Dinaric karst plateaus of Kočevski Rog and Kočevska Mala gora, the so-called contact karst is present. Geomorphic processes and landforms of four case study areas of contact karst were researched in detail. Two types of contact karst were recognized: between non-carbonate and carbonate rocks and between different carbonate rocks. In the first case, ponors and blind valleys (active and fossil were formed and concave forms near the contact are infilled with non-carbonate sediments. On the contact between different carbonate rocks (dolomite and limestone, the forms are similar but less evident, e.g. ponors (active and fossil, ponor steepheads and dry valleys.

  9. Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice

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    Xu, Qin; Zhu, Zhiwei; Xu, Jialu [Department of Children' s Health Care, Children' s Hospital, Zhejiang University, Hangzhou Zhejiang (China); Gu, Weizhong [Department of Pathology, Children' s Hospital, Zhejiang University, Hangzhou Zhejiang (China); Zhao, Zhengyan [Department of Children' s Health Care, Children' s Hospital, Zhejiang University, Hangzhou Zhejiang (China)

    2012-10-05

    Nitric oxide (NO), synthesized as needed by NO synthase (NOS), is involved in spinogenesis and synaptogenesis. Immature spine morphology is characteristic of fragile X syndrome (FXS). The objective of this research was to investigate and compare changes of postnatal neuronal NOS (nNOS) expression in the hippocampus of male fragile X mental retardation 1 gene knockout mice (FMR1 KO mice, the animal model of FXS) and male wild-type mice (WT) at postnatal day 7 (P7), P14, P21, and P28. nNOS mRNA levels were analyzed by real-time quantitative PCR (N = 4-7) and nNOS protein was estimated by Western blot (N = 3) and immunohistochemistry (N = 1). In the PCR assessment, primers 5′-GTGGCCATCGTGTCCTACCATAC-3′ and 5′-GTTTCGAGGCAGGTGGAAGCTA-3′ were used for the detection of nNOS and primers 5′-CCGTTTCTCCTGGCTCAGTTTA-3′ and 5′-CCCCAATACCACATCATCCAT-3′ were used for the detection of β-actin. Compared to the WT group, nNOS mRNA expression was significantly decreased in FMR1 KO mice at P21 (KO: 0.2857 ± 0.0150, WT: 0.5646 ± 0.0657; P < 0.05). Consistently, nNOS immunoreactivity also revealed reduced staining intensity at P21 in the FMR1 KO group. Western blot analysis validated the immunostaining results by demonstrating a significant reduction in nNOS protein levels in the FMR1 KO group compared to the WT group at P21 (KO: 0.3015 ± 0.0897, WT: 1.7542 ± 0.5455; P < 0.05). These results suggest that nNOS was involved in the postnatal development of the hippocampus in FXS and impaired NO production may retard spine maturation in FXS.

  10. Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice

    International Nuclear Information System (INIS)

    Nitric oxide (NO), synthesized as needed by NO synthase (NOS), is involved in spinogenesis and synaptogenesis. Immature spine morphology is characteristic of fragile X syndrome (FXS). The objective of this research was to investigate and compare changes of postnatal neuronal NOS (nNOS) expression in the hippocampus of male fragile X mental retardation 1 gene knockout mice (FMR1 KO mice, the animal model of FXS) and male wild-type mice (WT) at postnatal day 7 (P7), P14, P21, and P28. nNOS mRNA levels were analyzed by real-time quantitative PCR (N = 4-7) and nNOS protein was estimated by Western blot (N = 3) and immunohistochemistry (N = 1). In the PCR assessment, primers 5′-GTGGCCATCGTGTCCTACCATAC-3′ and 5′-GTTTCGAGGCAGGTGGAAGCTA-3′ were used for the detection of nNOS and primers 5′-CCGTTTCTCCTGGCTCAGTTTA-3′ and 5′-CCCCAATACCACATCATCCAT-3′ were used for the detection of β-actin. Compared to the WT group, nNOS mRNA expression was significantly decreased in FMR1 KO mice at P21 (KO: 0.2857 ± 0.0150, WT: 0.5646 ± 0.0657; P < 0.05). Consistently, nNOS immunoreactivity also revealed reduced staining intensity at P21 in the FMR1 KO group. Western blot analysis validated the immunostaining results by demonstrating a significant reduction in nNOS protein levels in the FMR1 KO group compared to the WT group at P21 (KO: 0.3015 ± 0.0897, WT: 1.7542 ± 0.5455; P < 0.05). These results suggest that nNOS was involved in the postnatal development of the hippocampus in FXS and impaired NO production may retard spine maturation in FXS

  11. Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice

    Directory of Open Access Journals (Sweden)

    Qin Xu

    2012-12-01

    Full Text Available Nitric oxide (NO, synthesized as needed by NO synthase (NOS, is involved in spinogenesis and synaptogenesis. Immature spine morphology is characteristic of fragile X syndrome (FXS. The objective of this research was to investigate and compare changes of postnatal neuronal NOS (nNOS expression in the hippocampus of male fragile X mental retardation 1 gene knockout mice (FMR1 KO mice, the animal model of FXS and male wild-type mice (WT at postnatal day 7 (P7, P14, P21, and P28. nNOS mRNA levels were analyzed by real-time quantitative PCR (N = 4-7 and nNOS protein was estimated by Western blot (N = 3 and immunohistochemistry (N = 1. In the PCR assessment, primers 5’-GTGGCCATCGTGTCCTACCATAC-3’ and 5’-GTTTCGAGGCAGGTGGAAGCTA-3’ were used for the detection of nNOS and primers 5’-CCGTTTCTCCTGGCTCAGTTTA-3’ and 5’-CCCCAATACCACATCATCCAT-3’ were used for the detection of β-actin. Compared to the WT group, nNOS mRNA expression was significantly decreased in FMR1 KO mice at P21 (KO: 0.2857 ± 0.0150, WT: 0.5646 ± 0.0657; P < 0.05. Consistently, nNOS immunoreactivity also revealed reduced staining intensity at P21 in the FMR1 KO group. Western blot analysis validated the immunostaining results by demonstrating a significant reduction in nNOS protein levels in the FMR1 KO group compared to the WT group at P21 (KO: 0.3015 ± 0.0897, WT: 1.7542 ± 0.5455; P < 0.05. These results suggest that nNOS was involved in the postnatal development of the hippocampus in FXS and impaired NO production may retard spine maturation in FXS.

  12. STRATEŠKO MARKETINŠKO NAČRTOVANJE BLAGOVNE ZNAMKE LIPA CAFE

    OpenAIRE

    Židov, Marko

    2014-01-01

    Današnji koncept marketinga poudarja dva poslovna cilja, ki sta enotna v velikih in majhnih podjetjih. To sta uspešno prepoznavanje potreb potencialnih kupcev in usmerjenost podjetja v ponujanje izdelkov oz. storitev, ki bodo zadovoljili potrebe in ob tem prinašali dobiček. Za doseganje dolgoročnih ciljev je potrebno razviti marketinške strategije. Ustrezno strateško načrtovanje obsega dovršeno analizo podjetja in okolja, v katerem poslujemo, tržno segmentiranje, izbiro ciljnih trgov, opredel...

  13. Transport blaga do visokogorskih planinskih koč

    OpenAIRE

    Kovšca, Rok

    2015-01-01

    V diplomskem delu smo se ukvarjali z analizo transporta blaga do visokogorskih planinskih koč, kjer smo kot glavni problem izpostavili nepovezanost in lokacijsko razdrobljenost koč. V okviru diplomske naloge smo najprej izvedli anketo med planinskimi društvi, ki so lastniki visokogorskih planinskih koč, in predstavili obstoječe stanje v Sloveniji. V naslednjem koraku smo naredili kritično analizo in s pomočjo vzročno-posledične in SWOT analize prikazali prednosti, slabosti, priložnosti, ...

  14. Perspektiva upravljanja gozdarskih koč v Julijskih Alpah

    OpenAIRE

    Šegina, Anamarija

    2014-01-01

    Diplomska naloga predstavlja predlog celovitega koncepta upravljanja gozdarskih koč v Julijskih Alpah. Danes gozdarske koče namreč ne služijo več bivanju gozdnih delavcev ter shranjevanju orodja in opreme. Njihov pomen se je povsem spremenil in tako dobivajo nove vloge v gozdnem prostoru. Te so povezane predvsem z nelesnimi funkcijami gozda, kot so turistična, rekreativna, izobraževalna in zdravstvena vloga. Gozdarske koče so v Julijskih Alpah različno ohranjene in izkoriščane. Opravljen je b...

  15. Speleološko djelovanje Mirka Maleza

    Directory of Open Access Journals (Sweden)

    Cvitanović, Hrvoje

    2011-06-01

    Full Text Available Since the very first beginning of his research work, started in 1946 Year, academian Mirko Malez has been recognised as very active and productive speleologist. In the frame of speleological researches he work on basically speleological recognising, physical research of caves and topographic plans. Due to fact that he was geologists, he has work also on other specialised researches: geology, geomorphology, genesis, hydrology, tectonic, palaeontology, archaeology, microclimate, biospeleology and other. In frame of research he regularly made photo documentation, what is today important professional and historical document of his researches. He works also on: cadastre development, speleological history, prompting and publication of speleological works and other. Therefore, it is not surprise that among 425 publications, of them more than half scientific works, majority belong to different aspects of speleology.His speleological research comprise today independent states: Bosnia and Herzegovina, Croatia, Macedonia, Monte Negro, Serbia and Slovenia, where he has researched around 1000 caves, majority of them in Croatia.His speleological researches M. Malez has published systematically since 1952 till 1974 Year, fully 23 Year, in Academian publication: Ljetopis JAZU. Many of articles deal with caves on some regions as: Ravna gora Mt. near Varaždin, Istria, Učka Mt., Ćićarija Mt., islands Iž and Ugljan, Cetina river region, Bitelić region, SW Lika region, Melnice region, Buško blato, Glamoč and Duvno polje region, region between Dubrovnik and Popovo polje, Rijeka region nad manyother.Also many articles deal with individual caves as: Vindija cave, Velika (Mačkova pećina cave, Veternica, Đulin ponor vace, Medvedica, Strašna peć cave, Hajdova hiža cave, Ledenica by Studenci cave, Drenovac cavern, Pits by Sušik, Đurkovina cave, Debelin cave, Romualdova spilja cave, Šandalja cave, Druška peć cave, Vergotinova peć cave, Pazinski ponor

  16. Suradničko učenje

    OpenAIRE

    Kadum-Bošnjak, Sandra

    2012-01-01

    Moderna škola zahtjeva moderne načine učenja i poučavanja, a suradničko učenje jedan je od takvih načina, koje je sve zastupljenije u nastavnoj praksi. U radu se, nakon definiranja pojmova 'suradnja' i 'suradničko učenje', daje pregled teorijskih osnova suradničkog učenja, prikazuje suradničko učenje u nastavi, kao i elemente suradničkog učenja. Ukazuje se, nadalje, i na prednosti suradničkog učenja u nastavi. Posebno se ukazuje na modele organiziranja i strategije suradničkog učenja....

  17. MARKETINŠKO KOMUNICIRANJE V IZOBRAŽEVALNIH INSTITUCIJAH

    OpenAIRE

    Pirih, Nina

    2012-01-01

    Obravnavamo področje se nanaša na marketinško komuniciranje izobraževalnih storitev. Marketinško komuniciranje je sestavni del splošnega procesa komuniciranja, skozi katerega organizacija vstopi v dialog z različnimi ciljnimi skupinami. V sloveniji se pojavlja kar nekaj neprofitnih organizacij, katerih cilj je zadovoljiti potrebe različnih interesnih skupin s svojimi proizvodi in storitvami. Ena izmed vej neprofitnih organizacij je tudi izobraževanje. Izobraževalne institucije z...

  18. Generalized Bernoulli numbers on the KO-theory

    OpenAIRE

    IMAOKA, MITSUNORI

    1996-01-01

    The Bernoulli number defined on the generalized cohomology theory is studied, mainly focusing it on complex unoriented theories. We give a concrete formula about it on the KO-theory for the stunted quaternionic quasi-projective space, and apply the formula to represent a factorization of the double transfer map concerning such projective spaces.

  19. Organ Correlation with Tryptophan Metabolism Obtained by Analyses of TDO-KO and QPRT-KO Mice

    Science.gov (United States)

    Shibata, Katsumi; Fukuwatari, Tsutomu

    2016-01-01

    The aim of this article is to report the organ-specific correlation with tryptophan (Trp) metabolism obtained by analyses of tryptophan 2,3-dioxygenase knockout (TDO-KO) and quinolinic acid phosphoribosyltransferase knockout (QPRT-KO) mice models. We found that TDO-KO mice could biosynthesize the necessary amount of nicotinamide (Nam) from Trp, resulting in the production of key intermediate, 3-hydroxyanthranilic acid. Upstream metabolites, such as kynurenic acid and xanthurenic acid, in the urine were originated from nonhepatic tissues, and not from the liver. In QPRT-KO mice, the Trp to quinolinic acid conversion ratio was 6%; this value was higher than expected. Furthermore, we found that QPRT activity in hetero mice was half of that in wild-type (WT) mice. Urine quinolinic acid levels remain unchanged in both hetero and WT mice, and the conversion ratio of Trp to Nam was also unaffected. Collectively, these findings show that QPRT was not the rate-limiting enzyme in the conversion. In conclusion, the limiting factors in the conversion of Trp to Nam are the substrate amounts of 3-hydroxyanthranilic acid and activity of 3-hydroxyanthranilic acid 3,4-dioxygenase in the liver. PMID:27147825

  20. Treatment of male varicoceles by transcatheter polidocanol foam sclerotherapy: evaluation of clinical success, complications, and patients&apos; satisfaction with regard to alternative techniques

    Energy Technology Data Exchange (ETDEWEB)

    Ali, Alma; Wirth, Stefan; Treitl, Karla Maria; Treitl, Marcus [Hospital of the Ludwig-Maximilians University of Munich, Institute for Clinical Radiology, Munich (Germany)

    2015-10-15

    We report our experience with polidocanol foam sclerotherapy with no additional coils, evaluating clinical success, patients&apos; satisfaction, and complications. We conducted a retrospective study of 141 patients with 146 varicoceles (mean age: 29.3 years; range: 13 - 60 years) who underwent foam sclerotherapy with polidocanol 2 % (range: 2 - 12 ml) in an outpatient setting between January 2007 and December 2013. For the follow-up, telephone interviews with the patients were conducted (mean follow-up time: 46.4 months, standard deviation: 20.17 months). The technical success rate was 91.8 %. There was a 55.8 % response rate to the telephone interviews. Follow-up revealed a clinical success rate of 83.9 % and a persistence or relapse rate of 16.1 %. Of the patients, 81.9 % were absolutely satisfied with the outcome. In 94.9 % of cases, pain or discomfort resolution was reported, and in 97 % of cases, aesthetic issues were no longer a problem. Of partners, 63.2 % achieved pregnancy, and in 50 % of patients with preprocedural testicular atrophy, catch-up growth was observed. One patient with pampiniform plexus phlebitis received inpatient treatment with no long-term damage recorded. Polidocanol foam varicocele sclerotherapy is a safe and effective procedure, with a high rate of patients&apos; satisfaction, clinical and technical success, and considerable catch-up growth and pregnancy achievement. (orig.)

  1. Gul'ko, descriptive, and Gruenhage compact spaces

    Czech Academy of Sciences Publication Activity Database

    Fabian, Marián; Montesinos, V.; Zizler, Václav

    2010-01-01

    Roč. 104, č. 2 (2010), s. 201-220. ISSN 1578-7303 R&D Projects: GA AV ČR IAA100190901; GA AV ČR(CZ) IAA100190610 Institutional research plan: CEZ:AV0Z10190503 Keywords : Gul'ko * descriptive * fragmentable compact spaces * network Subject RIV: BA - General Mathematics Impact factor: 0.400, year: 2010 http://link.springer.com/article/10.5052%2FRACSAM.2010.14

  2. Gastrointestinalhelminthosen bei Legehennen in deutschen Öko-Betrieben

    OpenAIRE

    Bauer, C; Brenninkmeyer, Ch.; Hirzmann, J; Maksimov, P.; Knierim, U.

    2015-01-01

    Ziel einer Querschnittsstudie war es, die bislang spärlichen Erkenntnisse über den Endoparasitenbefall bei Legehennen in ökologisch geführten Betrieben Deutschlands zu erweitern. Die Studiendurchführung erfolgte im Rahmen des europäischen Forschungsprojekts “HealthyHens“. In sieben Öko-Betrieben wurden jeweils 15 Legehennen (Lohmann Brown oder TetraSL) kurz vor Ende ihrer Legeperiode (ca. 70. Lebenswoche) mittels helminthologischer Teilsektion (Magen-Darm-Trakt) untersucht; Zestodenexemplare...

  3. ENERGETSKA SANACIJA OBJEKTA POKLICNE GASILSKE ENOTE KRŠKO

    OpenAIRE

    Abram, Marko

    2016-01-01

    Diplomsko delo obravnava sanacijo toplotnega ovoja stavbe Poklicne gasilske enote Krško. Najprej smo izvedli analizo objekta, ki ima energetsko potraten toplotni ovoj. Na osnovi rezultatov so izbrani ustrezni ukrepi za sanacijo (nova fasada, menjava oken, izolacija podstrešja,…), ki zmanjšujejo porabo energije in zadostijo zahtevam Pravilnika o učinkoviti rabi energije v stavbah in tehnični smernici TSG1-1-004:2010 - Učinkovita raba energije. Končni rezultat diplomskega dela je prikaz razlike...

  4. REPOZICIONIRANJE PREMIJSKE ZNAMKE NA PRIMERU ZNAMKE LAŠKO CLUB

    OpenAIRE

    Raušl, Miha

    2011-01-01

    Pozicioniranje je umetnost. Je poslovna strategija, ki je v zadnjih treh desetletjih prerasla z učinkovitejšega pristopa v oglaševanju v enega izmed ključnih marketinških procesov. Nedvomno lahko trdimo, da dandanes na svetovnih tržiščih potekajo prave bitke za košček odjemalčevega razuma, saj ob poplavi izdelkov, oglasov, znamk, znižanih cen v vseh različnih barvah in odtenkih odjemalec večino stvari podzavestno selektivno izbriše. Bistvo pozicioniranja mora izvirati iz ključnih koristi,...

  5. MEDVRSTNIŠKO NASILJE V PREDŠOLSKEM OBDOBJU

    OpenAIRE

    Poklič, Ksenija

    2010-01-01

    Diplomsko delo Medvrstniško nasilje v predšolskem obdobju je sestavljeno iz teoretičnega in empiričnega dela. Znotraj tega smo navedli in opisali, kaj je pojav medvrstniškega nasilja, kaj vpliva nanj, na kaj moramo biti pozorni. Pomemben poudarek smo dali tudi na vrtec, kot vzgojno-izobraževalno ustanovo in vzgojiteljico, kot pomemben dejavnik v otrokovem življenju v predšolskem obdobju. To smo v empiričnem delu tudi raziskali. Nasilje med vrstniki ni nov, je pa na žalost vedno pogostejši poj...

  6. MARKETINŠKO KOMUNICIRANJE V ODBOJKARSKEM KLUBU ACH VOLLEY

    OpenAIRE

    Horvat, Maja

    2011-01-01

    V diplomskem delu sem obravnavala marketinško komuniciranje v odbojkarskem klubu ACH Volley, s poudarkom na oglaševanju in odnosih z javnostmi. Dobri odnosi z vsemi javnostmi so postali pogoj za uspešno delovanje športnih klubov. Opisala sem tudi značilnosti pospeševanja prodaje, donatorstva in sponzorstva. Predstavila sem teoretične osnove marketinškega komuniciranja in jih kasneje nadgradila s praktičnimi primeri v ACH Volleyju. Predstavila sem v Sloveniji najuspešnejši odbojkarski klub...

  7. Oil protection action &apos;&apos;Green Aalesund&apos;&apos;; Oljevernaksjonen &apos;&apos;Green Aalesund&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    This report describes the actions taken after the refrigerator ship &apos;&apos;Green Aalesund&apos;&apos; ran aground north of Haugesund, Norway, on December 12, 2000. The report was worked out by the National State Pollution Control Authority (SFT). It is based on logs and other written documentation. The clean-up was carried out competently and successfully and the environmental damage was small.

  8. Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in ApoE knockout mice.

    Science.gov (United States)

    Park, Tae-Sik; Panek, Robert L; Rekhter, Mark D; Mueller, Sandra Bak; Rosebury, Wendy S; Robertson, Andrew; Hanselman, Jeffrey C; Kindt, Erick; Homan, Reynold; Karathanasis, Sotirios K

    2006-12-01

    Plasma sphingomyelin (SM) has been suggested as a risk factor for coronary heart disease independent of cholesterol levels. A decrease of SM in lipoproteins is known to improve the activities of lecithin:cholesterol acyltransferase (LCAT) and lipoprotein lipase (LPL) in vitro. Inhibition of SM biosynthesis may reduce lipoprotein SM content and thus improve cholesterol distribution in lipoproteins by enhancing reverse cholesterol transport and clearance of triglyceride-rich lipoproteins. To examine this hypothesis, ApoE KO mice were fed a western diet and treated for 4 weeks with various concentrations of myriocin, a specific inhibitor of serine palmitoyltransferase. Myriocin treatment lowered plasma cholesterol and TG levels in a dose-dependent manner. In addition, myriocin treatment reduced cholesterol contents in VLDL and LDL and elevated HDL-cholesterol. Observed lipid-lowering effects of myriocin were associated with suppression of HMG CoA reductase and fatty acid synthase via reduced levels of SREBP-1 RNA and protein. Induction of apoAI and lecithin:cholesterol acytransferase (LCAT) in the liver by myriocin was associated with an increased HDL. Lesion area and macrophage area were also diminished in the cuffed femoral artery of ApoE KO mice. In conclusion, inhibition of sphingolipid biosynthesis can be a novel therapeutic target for dyslipidemia and atherosclerosis. PMID:16458317

  9. Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory.

    Science.gov (United States)

    Biundo, Fabrizio; Ishiwari, Keita; Del Prete, Dolores; D'Adamio, Luciano

    2015-12-01

    Mutations in Amyloid β Precursor Protein (APP) and in genes that regulate APP processing--such as PSEN1/2 and ITM2b/BRI2--cause familial dementia, such Familial Alzheimer disease (FAD), Familial Danish (FDD) and British (FBD) dementias. The ApoE gene is the major genetic risk factor for sporadic AD. Three major variants of ApoE exist in humans (ApoE2, ApoE3, and ApoE4), with the ApoE4 allele being strongly associated with AD. ITM2b/BRI2 is also a candidate regulatory node genes predicted to mediate the common patterns of gene expression shared by healthy ApoE4 carriers and late-onset AD patients not carrying ApoE4. This evidence provides a direct link between ITM2b/BRI2 and ApoE4. To test whether ApoE4 and pathogenic ITM2b/BRI2 interact to modulate learning and memory, we crossed a mouse carrying the ITM2b/BRI2 mutations that causes FDD knocked-in the endogenous mouse Itm2b/Bri2 gene (FDDKI mice) with human ApoE3 and ApoE4 targeted replacement mice. The resultant ApoE3, FDDKI/ApoE3, ApoE4, FDDKI/ApoE4 male mice were assessed longitudinally for learning and memory at 4, 6, 12, and 16-17 months of age. The results showed that ApoE4-carrying mice displayed spatial working/short-term memory deficits relative to ApoE3-carrying mice starting in early middle age, while long-term spatial memory of ApoE4 mice was not adversely affected even at 16-17 months, and that the FDD mutation impaired working/short-term spatial memory in ApoE3-carrying mice and produced impaired long-term spatial memory in ApoE4-carrying mice in middle age. The present results suggest that the FDD mutation may differentially affect learning and memory in ApoE4 carriers and non-carriers. PMID:26528887

  10. Apolipoprotein A-I inhibits LPS-induced atherosclerosis in ApoE-/-mice possibly via activated STAT3-mediated upregulation of tristetraprolin

    Institute of Scientific and Technical Information of China (English)

    Kai YIN; Shi-lin TANG; Xiao-hua YU; Guang-hui TU; Rong-fang HE; Jin-feng LI; Di XIE

    2013-01-01

    Aim:To investigate the effects of the major component of high-density lipoprotein apolipoprotein A-I (apoA-I) on the development of atherosclerosis in LPS-challenged ApoE-/-mice and the underlying mechanisms.Methods:Male ApoE-KO mice were daily injected with LPS (25 μg,sc) or PBS for 4 weeks.The LPS-challenged mice were intravenously injected with rAAV-apoA-I-GFP or rAAV-GFP.After the animals were killed,blood,livers and aortas were collected for biochemical and histological analyses.For ex vivo experiments,the abdominal cavity macrophages were harvested from each treatment group of mice,and cultured with autologous serum,then treated with LPS.Results:Chronic administration of LPS in ApoE-/-mice significantly increased the expression of inflammatory cytokines (TNF-α,IL-1β,IL-6,and MCP-1),increased infiltration of inflammatory cells,and enhanced the development of atherosclerosis.In LPS-challenged mice injected with rAAV-apoA-I-GFP,viral particles and human apoA-I were detected in the livers,total plasma human apoA-I levels were grammatically increased; HDL-cholesterol level was significantly increased,TG and TC were slightly increased.Furthermore,overexpression of apoA-l significantly suppressed the expression of proinflammatory cytokines,reduced the infiltration of inflammatory cells,and decreased the extent of atherosclerotic lesions.Moreover,overexpression of apoA-I significantly increased the expression of the cytokine mRNA-destabilizing protein tristetraprolin (TTP),and phosphorylation of JAK2 and STAT3 in aortas.In ex vivo mouse macrophages,the serum from mice overexpressing apoA-I significantly increased the expression of TTP,accompanied by accelerated decay of mRNAs of the inflammatory cytokines.Conclusion:ApoA-I potently suppresses LPS-induced atherosclerosis by inhibiting the inflammatory response possibly via activation of STAT3 and upregulation of TTP.

  11. Sarcocystis neurona infection in gamma interferon gene knockout (KO) mice: comparative infectivity of sporocysts in two strains of KO mice, effect of trypsin digestion on merozoite viability, and infectivity of bradyzoites to KO mice and cell culture.

    Science.gov (United States)

    Dubey, J P; Sundar, N; Kwok, O C H; Saville, W J A

    2013-09-01

    The protozoan Sarcocystis neurona is the primary cause of Equine Protozoal Myeloencephalitis (EPM). EPM or EPM-like illness has been reported in horses, sea otters, and several other mammals. The gamma interferon gene knockout (KO) mouse is often used as a model to study biology and discovery of new therapies against S. neurona because it is difficult to induce clinical EPM in other hosts, including horses. In the present study, infectivity of three life cycle stages (merozoites, bradyzoites, sporozoites) to KO mice and cell culture was studied. Two strains of KO mice (C57-black, and BALB/c-derived, referred here as black or white) were inoculated orally graded doses of S. neurona sporocysts; 12 sporocysts were infective to both strains of mice and all infected mice died or became ill within 70 days post-inoculation. Although there was no difference in infectivity of sporocysts to the two strains of KO mice, the disease was more severe in black mice. S. neurona bradyzoites were not infectious to KO mice and cell culture. S. neurona merozoites survived 120 min incubation in 0.25% trypsin, indicating that trypsin digestion can be used to recover S. neurona from tissues of acutely infected animals. PMID:23375195

  12. The strategic &apos;'pull'&apos; and operational &apos;'push'&apos; of total quality management in UK regional electricity service companies

    Energy Technology Data Exchange (ETDEWEB)

    McAdam, R.; McLean, J.; Henderson, J.

    2003-04-30

    The aim of this paper is to evaluate whether the UK regional electricity companies (RECs) has used total quality management (TQM) as a &apos;'push'&apos; or as a &apos;'pull'&apos; change methodology. &apos;'Push'&apos; is the operational improvement role of TQM; &apos;'pull'&apos; is the strategic or direction giving, improvement role of TQM. Following the onset of privatisation in 1990 there has been evidence of the RECs adopting TQM in both &apos;'push'&apos; and &apos;'pull'&apos; methodologies with varying degrees of success. An evaluation of the change processes involved will enable improved change models to be developed leading to increased business effectiveness in this 30 billion pounds sterling industry. Other possible benefits include the possible generalisations to other utilities such as water, roads, gas and telecoms. The research methodology includes a comparative case study analysis of five RECs, which have used TQM as their overarching approach to change. One of the cases is analysed to a more in-depth level based on the multiple case findings. The findings indicate that the &apos;'push-pull'&apos; analysis enables the full range of TQM activities to be evaluated in the RECs studied. Overall, there is a need to have a balanced portfolio of operational or &apos;'push'&apos;-based TQM activity that is driven by strategic or &apos;'pull'&apos; based TQM planning and activity. (author)

  13. Characterization of the insulin sensitivity of ghrelin receptor KO mice using glycemic clamps

    Directory of Open Access Journals (Sweden)

    Morgan Kristen

    2011-01-01

    Full Text Available Abstract Background We and others have demonstrated previously that ghrelin receptor (GhrR knock out (KO mice fed a high fat diet (HFD have increased insulin sensitivity and metabolic flexibility relative to WT littermates. A striking feature of the HFD-fed GhrR KO mouse is the dramatic decrease in hepatic steatosis. To characterize further the underlying mechanisms of glucose homeostasis in GhrR KO mice, we conducted both hyperglycemic (HG and hyperinsulinemic-euglycemic (HI-E clamps. Additionally, we investigated tissue glucose uptake and specifically examined liver insulin sensitivity. Results Consistent with glucose tolerance-test data, in HG clamp experiments, GhrR KO mice showed a reduction in glucose-stimulated insulin release relative to WT littermates. Nevertheless, a robust 1st phase insulin secretion was still achieved, indicating that a healthy β-cell response is maintained. Additionally, GhrR KO mice demonstrated both a significantly increased glucose infusion rate and significantly reduced insulin requirement for maintenance of the HG clamp, consistent with their relative insulin sensitivity. In HI-E clamps, both LFD-fed and HFD-fed GhrR KO mice showed higher peripheral insulin sensitivity relative to WT littermates as indicated by a significant increase in insulin-stimulated glucose disposal (Rd, and decreased hepatic glucose production (HGP. HFD-fed GhrR KO mice showed a marked increase in peripheral tissue glucose uptake in a variety of tissues, including skeletal muscle, brown adipose tissue and white adipose tissue. GhrR KO mice fed a HFD also showed a modest, but significant decrease in conversion of pyruvate to glucose, as would be anticipated if these mice displayed increased liver insulin sensitivity. Additionally, the levels of UCP2 and UCP1 were reduced in the liver and BAT, respectively, in GhrR KO mice relative to WT mice. Conclusions These results indicate that improved glucose homeostasis of GhrR KO mice is

  14. The first Koç Han: Pioneering modern architecture in Ankara

    Directory of Open Access Journals (Sweden)

    Oya Atalay Franck

    2013-01-01

    Full Text Available Koç Holding is the most established conglomerate in Turkey. Th e company’s beginnings date from the mid 1920s, when Ahmet Vehbi Koç, founder of Koç Holding, had his first own company registered with the Ankara Chamber of Commerce. In 1932, Koç moved his business from his father’s store on Anafartalar Street to a new building, the first Koç Han, erected the same year on Çankırı Street Nr.13 in Ulus. Th e building’s designer was Swiss-Austrian architect Ernst Arnold Egli, who had come to Turkey only five years earlier upon invitation by the government to work as chief architect of the Ministry of National Education. During his stay, which lasted from 1927 until 1940, Egli realized about 40 projects and worked on many more. Koç Han is the rare example of a commercial building by Egli. At a time when the urban aspect of the old town center of Ankara consisted mostly of one-or two-storeyed stone-and-wood houses, the first Koç Han represented an altogether new building type for the town, in being a multipurpose edifice with space for shops at street level, with large storage facilities below ground, and providing off ices and housing on the upper fl oors. Th e functional rigor of the plan and the sober modernism of the building’s facades contrasted strongly with the architecture of the time. In this respect, the first Koç Han was a strong statement regarding Ahmet Vehbi Koç’s belief in a modern Turkey and to the contribution of the building’s architect, Ernst Arnold Egli, to this project.

  15. A comprehensive study of distribution laws for the fragments of Košice meteorite

    OpenAIRE

    Gritsevich, Maria; Vinnikov, Vladimir; Kohout, Tomas; Toth, Juraj; Peltoniemi, Jouni; Turchak, Leonid; Virtanen, Jenni

    2014-01-01

    Abstract–In this study, we conduct a detailed analysis of the Košice meteorite fall (February28, 2010), to derive a reliable law describing the mass distribution among the recovered fragments. In total, 218 fragments of the Košice meteorite, with a total mass of 11.285 kg, were analyzed. Bimodal Weibull, bimodal Grady, and bimodal lognormal distributions are found to be the most appropriate for describing the Košice fragmentation process. Based on the assumption of bimodal lognormal, bim...

  16. A comprehensive study of distribution laws for the fragments of Ko\\v{s}ice meteorite

    OpenAIRE

    Gritsevich, Maria; Vinnikov, Vladimir; Kohout, Tomáš; Tóth, Juraj; Peltoniemi, Jouni; Turchak, Leonid; Virtanen, Jenni

    2014-01-01

    In this study, we conduct a detailed analysis of the Ko\\v{s}ice meteorite fall (February 28, 2010), in order to derive a reliable law describing the mass distribution among the recovered fragments. In total, 218 fragments of the Ko\\v{s}ice meteorite, with a total mass of 11.285 kg, were analyzed. Bimodal Weibull, bimodal Grady and bimodal lognormal distributions are found to be the most appropriate for describing the Ko\\v{s}ice fragmentation process. Based on the assumption of bimodal lognorm...

  17. Struktura i dinamika obiteljskih odnosa mladih u Dubrovačko-neretvanskoj županiji

    OpenAIRE

    Bouillet, Dejana

    2006-01-01

    Ovaj je rad dio znanstvenog projekta “Praćenje korištenja sredstava ovisnosti u populaciji srednjoškolaca Dubrovačko-neretvanske županije” što ga od 2001. godine kontinuirano provodi i financira Zavod za javno zdravstvo Dubrovač ko-neretvanske županije. Uzorak istraživanja čine reprezentativno izabrani učenici svih srednjih škola Dubrovačko-neretvanske županije koji su u proljeće 2003. (N = 1298) i 2006. godine (N = 1485) anonimno popunjavali upitnik pod nazivom “Kako si?” (...

  18. ODREĐIVANJE LOKACIJE SMJEŠTAJA LOGISTIČKO-DISTRIBUCIJSKOG CENTRA ŠIBENIK

    OpenAIRE

    Šego, Darijo; Poljičak, Ana-Mari; Martina LJUBIĆ HINIĆ

    2016-01-01

    Logističko-distribucijski centri predstavljaju suvremeni objekt u kojem se prihvaća, čuva, dorađuje i priprema roba za daljnju distribuciju do kupca. U ovom radu biti će prikazano određivanje lokacije smještaja Logističko-distribucijskog centra Šibenik. Izgradnjom, opremanjem i puštanjem u rad Logističko-distribucijskog centra Šibenik za neprehrambene proizvode, grad Šibenik dobio bi novu vrijednost u svom gospodarskom i prometnom razvoju. Lokacija smještaja je određena na temelju vrednovanja...

  19. Mixed municipal solid waste (MSW) treatment in Waste centre Spodnji Stari Grad, Krško

    OpenAIRE

    Kortnik, Jože; Leskovar, Jože

    2015-01-01

    Review paper Received: October 25, 2013 Accepted: November 7, 2013 Mixed municipal solid waste (MSW) treatment in Waste centre Spodnji Stari Grad, Krško Ravnanje z mešanimi komunalnimi odpadki v Zbirnem centru Spodnji Stari Grad, Krško Jože Kortnik1'*, Jože Leskovar2 University of Ljubljana, Faculty of Natural Sciences and Engineering, Department of Mining and Geotechnology, Aškerčeva 12, 1000 Ljubljana, Slovenia 2Kostak, d. d., Leskovška cesta 2a, 8270 Krško, Slovenia Correspo...

  20. Effect of Cyp27A1 gene dosage on atherosclerosis development in ApoE-knockout mice

    OpenAIRE

    Zurkinden, Line; Solcà, Curzio; Vögeli, Isabelle A.; Vogt, Bruno; Ackermann, Daniel; Erickson, Sandra K.; Frey, Felix J; Sviridov, Dmitri; Escher, Geneviève

    2014-01-01

    In humans, sterol 27-hydroxylase (CYP27A1) deficiency leads to cholesterol deposition in tendons and vasculature. Thus, in addition to its role in bile acid synthesis, where it converts cholesterol to 27-hydroxycholesterol (27-OHC), CYP27A1 may also be atheroprotective. Cyp27A1-deficient (Cyp27A1−/−) mice were crossed with apolipoprotein E (apoE)-deficient mice. Cyp27A1+/+/apoE−/− [ApoE-knockout (KO)], Cyp27A1+/−/apoE−/− heterozygous (het), and Cyp27A1−/−/apoE−/− [double-knockout (DKO)] mice ...

  1. High energy X-ray laboratory &apos;'HEXYLab'&apos;. The new facility &apos;'HEXYTech'&apos;; Hochenergie-Roentgen-Labor &apos;'HEXYLab'&apos;. Die neue Anlage &apos;'HEXYTech'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Redmer, Bernhard; Hohendorf, Stefan; Kolkoori, Sanjeevareddy; Wrobel, Norma; Ewert, Uwe [BAM Bundesanstalt fuer Materialforschung und -pruefung, Berlin (Germany)

    2015-07-01

    High-energy radiography is used traditionally for the detection of defects in the thick-walled, bulky components. It is also used for testing the integrity of components for civil and security related applications (containers). The combination of high-energy emitters with digital detector arrays or line cameras allows test procedures in a shorter time compared to film or higher contrast sensitivity. The high-energy X-ray laboratory HEXYLab BAM is a joint laboratory in which future users, manufacturers and scientists can initiate and develop joint development projects. The new universal manipulation system HEXYTech forms the engineering and technical base for the most diverse requirements in HEXYLab (High Energy X-raY Lab.). With a total of 13 rotary and linear axes the diverse trajectories for tube, object and detector can be programmed. So large objects with complex geometries can be examined. 2D and 3D images can be measured by simple radiography, and laminography and computed tomography. The general rules for the application of high energy radiography with digital detectors (imaging plates, Digital detector arrays) were determined within the framework of the European project &apos;'HEDRad'&apos; (High Energy Digital Radiography) and included in the standard DIN EN ISO 17636-2. This article gives an overview of the testing technology and presents the possible applications on the basis of images and experiments. (PowerPoint slides). [German] Hochenergie-Radiographie wird traditionell fuer die Detektion von Defekten in dickwandigen, sperrigen Komponenten angewendet. Sie wird auch genutzt fuer die Pruefung der Komponentenintegritaet bei zivilen und sicherheitsrelevanten Anwendungen (Container). Die Kombination von Hochenergie- Strahlern mit digitalen Detektorarrays oder Zeilenkameras ermoeglicht die Pruefungsdurchfuehrung in kuerzerer Zeit im Vergleich zum Film oder mit hoeherer Kontrastempfindlichkeit. Das Hochenergie-Roentgen-Labor &apos;'HEXYLab'&apos

  2. Longitudinal Links between Fathers&apos; and Mothers&apos; Harsh Verbal Discipline and Adolescents&apos; Conduct Problems and Depressive Symptoms

    Science.gov (United States)

    Wang, Ming-Te; Kenny, Sarah

    2014-01-01

    This study used cross-lagged modeling to examine reciprocal relations between maternal and paternal harsh verbal discipline and adolescents&apos; conduct problems and depressive symptoms. Data were from a sample of 976 two-parent families and their children (51% males; 54% European American, 40% African American). Mothers&apos; and fathers&apos;…

  3. Poland&apos;s syndrome: radiologic findings

    Energy Technology Data Exchange (ETDEWEB)

    Bazzi Junior, Joao Lourenco, E-mail: joaobazzijr@gmail.com [Clinica Via Imagem, Xanxere, SC (Brazil); Matta, Eduardo Simoes da [Pro Circulacao - Clinica de Angiologia, Cirurgia Vascular e Ecografia Vascular, Xanxere, SC (Brazil); De Bortoli, Luciano [Materclinica Materno Infantil, Xanxere, SC (Brazil); De Bortoli, Felipe Raasch [Universidade Catolica de Pelotas (UCPel), Pelotas, RS (Brazil). Fac. of Medicine

    2012-05-15

    Poland&apos;s syndrome is a rare non-inherited congenital anomaly. The authors describe the classic radiologic findings of Poland&apos;s syndrome by reporting the case of a male four-year old patient with asymmetry of hands and chest, illustrating the fundamental imaging criteria for a conclusive diagnosis. (author)

  4. Zloćudni tumori kože i mekih tkiva

    OpenAIRE

    Šitum, Mirna

    2001-01-01

    Zloćudni tumori kože i mekih tkiva pripadaju intrigantnom području mnogih grana medicine. U članku je prikazana podjela tih tumora i prikazana etiopatogeneza, incidencija, klinička slika, dijagnostika, te postupci liječenja onih najčešćih, ali i nekih rjeđih oblika tih tumora. Osobito pregledno prikazani su invazivni intraepidermalni karcinomi kože (BCC, SCC) i maligni melanom.

  5. Condoms - male

    Science.gov (United States)

    Prophylactics; Rubbers; Male condoms; Contraceptive-condom; Contraception-condom; Barrier method-condom ... The male condom is a thin cover that fits over a man's erect penis . Condoms are made of: Animal ...

  6. Oil protection &apos;&apos;John R&apos;&apos;; Oljevernaksjon &apos;&apos;John R&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    The report briefly reviews the emergency actions after the bulk ship &apos;&apos;John R&apos;&apos; ran aground off Troms on December 15, 2002. The report was worked out by the contingency and control division at the National State Pollution Control Authority (SFT). SFT mobilized their own action organization to attend to the oil pollution preparedness around the disabled ship. The Norwegian Directorate of Shipping and Navigation (SD) mobilized in order to attend to a possible emergency discharging of the ship. In the opening phase, the situation was handled by Defence Command North Norway. The report is built on logs and other written documentation from the Coast Guard and from SFT. Material from several other participants are also included. The harmful effects on the environment were kept to a minimum. Altogether oil damage was observed on 1300 - 1800 sea birds. Only minor shores in three areas were affected.

  7. Košice meteorite - recovery and the strew field

    Science.gov (United States)

    Toth, J.; Porubčan, V.; Borovička, J.; Igaz, A.; Spurný, P.; Svoreň, J.; Husárik, M.; Kornoš, L.; Vereš, P.; Zigo, P.; Koza, J.; Kučera, A.; Gajdoš, S.; Világi, J.; Čapek, D.; Šilha, J.; Schunová, E.; Krišandová, Z.; Tomko, D.; Bodnárová, M.; Búzová, D.; Krejčová, T.

    2012-09-01

    The glare of the bolide on the night of February 28, 2010, illuminated streets and interior of apartments, at some places in Eastern Slovakia and Northern Hungary and cannon-like burst or series of low frequency blasts were heard. Due to bad weather, cloudy skies and scatter showers the Central European Fireball Network (operated by Pavel Spurný of the Czech Academy of Sciences) did not take direct optical records of the bolide and also the Slovak Video Meteor Network (operated by Juraj Tóth of Comenius University in Bratislava) did not operate that night so that at first moment it seemed that there were no scientific records available of this event. Fortunately, fast photoelectric sensors on 7 automated fireball stations in the Czech Republic (6) and Austria (1) worked also under cloudy sky and recorded the light curve of the bolide. It enabled to determine the exact time and duration of the event and to estimate its brightness as well. The bolide reached the maximum brightness of at least -18 magnitudes in one huge flare. This light curve was used also for modeling of meteoroid atmospheric fragmentation. Later, several surveillance cameras data were published showing the moment when the night became a day. Three videos from Hungary (Örkény village, Fazzi Daniella and Vass Gábor; Telki village, contact persons Sárneczky Krisztián, Kiss László and Budapest) actually captured the fireball itself. Thanks to calibration of videos by several members of the Hungarian Astronomical Association (MCSE - www.mcse.hu, namely by Igaz Antal) and the trajectory analysis done by Jiří Borovička gave the hope that significant number of meteorite fragments reached the surface. He also calculated the impact area western of the city of Košice in Eastern Slovakia. The data from the Local Seismic Network of Eastern Slovakia (Peter Moczo of the Comenius University) analyzed by Pavel Kalenda confirmed the atmospheric trajectory as well [1].

  8. Za charaktera na češko-bălgarskite i slovaško-bălgarskite literaturni otnošenija

    Czech Academy of Sciences Publication Activity Database

    Černý, Marcel

    2011-01-01

    Roč. 8, č. 12 (2011), s. 9-26. ISSN 1312-5346 Institutional support: RVO:68378017 Keywords : Czech-Bulgarian literary relations * Slovak-Bulgarian literary relations * Ján Koška * literary reception Subject RIV: AJ - Letters, Mass-media, Audiovision

  9. The trochlear cleft: the &apos;&apos;black line&apos;&apos; of the trochlear trough

    Energy Technology Data Exchange (ETDEWEB)

    Wissman, Robert D.; Nepute, Joshua; Fischer, Nathaniel von; Radhakrishnan, Rupa; Hendry, Daniel [University of Cincinnati Medical Center, Department of Radiology, Cincinnati, OH (United States); Ingalls, Jerrell [Desert Radiologists, Las Vegas, NV (United States); Kenter, Keith [University of Cincinnati Medical Center, Department of Orthopaedic Surgery, Cincinnati, OH (United States)

    2012-09-15

    The &apos;&apos;cartilage black line sign&apos;&apos; is a recently described T2 dark cartilage lesion that we have identified appearing as a cleft in the trochlear trough. The purpose of our study was to define the MR imaging characteristics of a trochlear cleft, determine its incidence, and correlate the MR findings with arthroscopy. A total of 1,300 consecutive MR examinations of the knee were retrospectively reviewed by consensus of two fellowship-trained musculoskeletal radiologists. The MR imaging characteristics and location of a trochlear cleft were determined. Imaging results were compared to arthroscopy when available. Patient age and gender were compared to 25 randomly selected control patients without trochlear clefts. A total of 25 (1.9%) individuals (11 females and 14 males; age range 19-45 years; mean age 28 years) were diagnosed with a trochlear cleft. The control group consisted of 11 females and 14 males; age range 19-83 years; mean age 46 years. Mean cleft length was 7 mm (range 6-12 mm); cleft location was consistently in the lower trochlear trough. No full-thickness cartilage defects were identified in the eight individuals in whom arthroscopic correlation was available. A grade 2 cartilage lesion was identified in a single individual; another progressed from grade 0 to a full-thickness trochlear lesion over an 8-month interval. Eight individuals were athletes. No significant difference in gender was noted between the two groups, however, the study group was significantly younger p < 0.0001. A trochlear cleft is a rare finding in young active individuals. It most likely indicates an incomplete cartilage fissure which may rarely progress to a full-thickness defect. (orig.)

  10. The &apos;'invisible'&apos; radioactive scale

    Energy Technology Data Exchange (ETDEWEB)

    Bjoernstad, T.; Ramsoey, T

    1999-04-01

    Production and up-concentration of naturally occurring radioactive material (NORM) in the petroleum industry has attracted steadily increasing attention during the last 15 years. Most production engineers today associate this radioactivity with precipitates (scales) and sludges in production tubing, pumps, valves, separators, settling tanks etc., wherever water is being transported or treated. {sup 226}Ra and {sup 228}Ra are the most well known radioactive constituents in scale. Surprisingly little known is the radioactive contamination by {sup 210}Pb and progeny {sup 210}Bi and {sup 210}Po. These are found in combination with {sup 226}Ra in ordinary scale, often in layer of non-radioactive metallic lead in water transportation systems, but also in pure gas and condensate handling systems &apos;'unsupported'&apos; by {sup 226}Ra, but due to transportation and decay of the noble gas {sup 222}Rn in NG/LNG. This latter contamination may be rather thin, in some cases virtually invisible. When, in addition, the radiation energies are low enough for not being detectable on the equipment outer surface, its existence has for most people in the industry been a secret. The report discusses transportation and deposition mechanisms, detection methods and provides some examples of measured results from the North Sea on equipment sent for maintenance. It is concluded that a regular measurement program for this type of contamination should be mandatory under all dismantling processes of transportation and fluid handling equipment for fluids and gases offshore and onshore.

  11. Country report: Lithuania. &apos;&apos;Best practice&apos;&apos; projects and measures in Lithuania

    Energy Technology Data Exchange (ETDEWEB)

    Kazakevicius, E. [Housing and Urban Development Foundation (Lithuania); Jarasunas, V. [Energy Efficiency Center (Lithuania); Skema, R. [Lithuanian Energy Inst. (Lithuania)

    2002-11-01

    The authors report on selected &apos;&apos;best practice&apos;&apos; energy efficiency and renewable energy projects and measures in Lithuania: thermal energy conservation in the building sector, energy audits in industry, biomass utilization. (uke)

  12. Hydrogeology of the transition area between Prekmursko polje and Goričko (NE Slovenia

    Directory of Open Access Journals (Sweden)

    Katja Koren

    2015-12-01

    Full Text Available In April 2014 a detailed hydrogeological mapping was performed in the transition area between the hilly Goričko in the north and the fltland of Prekmursko polje in the south (NE Slovenia. The occurrence of groundwater and surface water phenomena were registered and groundwater levels determined in a number of dug wells. Some basic physico-chemical parameters of water, i.e. temperature, electrical conductivity and pH were measured. Groundwater level map of the area was drawn and groundwater flw directions determined. In the Goričko area, groundwater flws from north to south, while in Prekmursko polje groundwater flw is parallel to the flw of the Mura River, i.e. NW-SE. In the transition area between Goričko and Prekmursko polje groundwater countor lines bend substantialy indicating a change in the relief as well as change of the hydrogeological characteristic of sediments. The groundwater pH and temperatures in Goričko and Prekmursko polje, are simillar. However, the electrical conductivity of groundwater in Prekmursko polje is higher than in Goričko.

  13. Application of ko-NAA technique on Dalat research reactor for human hair analysis in environmental pollution study

    International Nuclear Information System (INIS)

    The ko-standardization method of neutron activation analysis (ko-NAA) has recently been developed on Dalat research reactor. However, in order to apply the ko-NAA technique for practical research objects, it is necessary to establish different experimental procedures for each object. This work is aiming at establishing such a ko-NAA procedure on Dalat research reactor for human hair samples to solve the environmental pollution study prob;em. Therefore, the sample collection and preparation, irradiation, gamma-ray spectrum measurement and data processing, as well as quality assurance and quality control of the ko-NAA procedure for human hair samples have been assessed by comparing with elemental concentrations in terms of the experimental to certified values ratio and U-score. The experimental results showed that the ko-NAA for multi-element in human hair sample analysis is able to apply on Dalat research reactor with a rather good analytical quality. (author)

  14. Analysis of the problem nuclear safety review of &apos;'Ukryttya'&apos; object

    International Nuclear Information System (INIS)

    Basic tasks of nuclear safety control for severe accidents at nuclear power plants on example of &apos;'Ukryttya'&apos; object are shown. The analysis of these tasks solution experience at ChNPP accident elimination is conducted. Actual problems are noted and perspective ways for their decision are pointed out. Necessity of research continuation for this theme at &apos;'Ukryttya'&apos; object basis for nuclear power engineering effectiveness and safety improving is shown

  15. Development and deployment of a novel &apos;'yellow'&apos; demulsifier for the gullfaks &apos;'A'&apos; platform

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, S.J.; Ingebrigtsen, T.; Breen, P.J.; Waage, J.; Thorstenson, T.; Melby, S.

    2006-03-15

    Oil producers are increasingly under pressure to produce their product in an environmentally sound manner. Releases to the environment are undesirable and, where permitted to make such releases, oil producers should minimise their environmental impact. The bulk of treatment chemicals designed to improve separation and provide clean water for disposal can themselves be harmful to the environment and must conform to very stringent rules to be considered environmentally acceptable, or &apos;'green'&apos;. Here we present data on the development of a green demulsifier for Statoil&apos;s Gullfaks &apos;'A'&apos; platform, which not only meets the very stringent regulations but also exhibits a significant improvement in product performance. While the&apos;&apos;bottle test&apos;&apos; remains the industry standard method for selecting demulsifiers, in recent years the &apos;&apos;mini trial&apos;&apos; method for product selection has gained favour. We describe using a combination of both methods for the development of the novel demulsifier technology described here. (Author) (tk)

  16. Uloga empatije u socijalizaciji djece s teškoćama u razrednim sredinama

    OpenAIRE

    Špelić, Aldo; Zuliani, Đeni

    2011-01-01

    Potaknuti istraživanjima o pozitivnim posljedicama uključivanja djece s teškoćama u redovnu razrednu nastavu za ostale učenike tipičnog razvoja u ovom smo istraživanju ispitali 1) postoji li razlika u empatiji učenika koji su pohađali nastavu u istom razrednom odjeljenju s učenicima s teškoćama tijekom tri ili četiri godine i onih učenika koji nisu imali takvo iskustvo; 2) kolika je prihvaćenost/neprihvaćenost učenika s teškoćama u njihovim razrednim sredinama i postoji li razlika u empatiji ...

  17. Nasilje nad osobama s intelektualnim teškoćama

    OpenAIRE

    Josipović, Ana Marija; Najman Hižman, Elizabeta; Leutar, Zdravka

    2008-01-01

    U ovom radu se istražuje nasilje nad osobama s intelektualnim teškoćama. Budući da je ova problematika u domaćoj literaturi gotovo nepoznata, uvodni dio donosi strana istraživanja vezana uz različite oblike nasilja nad osobama s intelektualnim teškoćama i zakonske odrednice nasilja nad osobama s invaliditetom. Cilj ovog rada bio je ispitati koliko su osobe s intelektualnim teškoćama žrtve nasilja, koje vrste nasilja najčešće doživljavaju i tko su najčešći počinitelji nasilja. Ispitivanje je p...

  18. Naracija u djece s posebnim jezičnim teškoćama

    OpenAIRE

    GROBLER Marinka; Arapović, Diana

    2006-01-01

    Posebne jezične teškoće (nadalje PJT) su razvojni poremećaj različitih profila i stupnjeva izraženosti jezičnih teškoća u kontekstu normalnih kognitivnih sposobnosti, a bez prisutnog poznatog uzroka (Bishop, 1992, Leonard, 1998.) Cilj ovog rada bio je istražiti obilježja naracije i utvrditi razlike između skupine djece s posebnim jezičnim teškoćama i skupine djece urednoga jezičnoga razvoja. Ispitivanje je provedeno na dva uzorka ispitanika. Prvi uzorak činilo je 71 dijete, koje je zbog dijag...

  19. Chronic hyperbaric oxygen treatment elicits an anti-oxidant response and attenuates atherosclerosis in apoE knockout mice.

    Science.gov (United States)

    Kudchodkar, Bhalchandra J; Pierce, Anson; Dory, Ladislav

    2007-07-01

    We previously demonstrated that hyperbaric oxygen (HBO) treatment inhibits diet-induced atherosclerosis in New Zealand White rabbits. In the present study we investigate the mechanisms that might be involved in the athero-protective effect of HBO treatment in a well-accepted model of atherosclerosis, the apoE knockout (KO) mouse. We examine the effects of daily HBO treatment (for 5 and 10 weeks) on the components of the anti-oxidant defense mechanism and the redox state in blood, liver and aortic tissues and compare them to those of untreated apoE KO mice. HBO treatment results in a significant reduction of aortic cholesterol content and decreased fatty streak formation. These changes are accompanied by a significant reduction of autoantibodies against oxidatively modified LDL and profound changes in the redox state of the liver and aortic tissues. A 10-week treatment significantly reduces hepatic levels of TBARS and oxidized glutathione, while significantly increases the levels of reduced glutathione, glutathione reductase (GR), transferase, Se-dependent glutathione peroxidase and catalase (CAT). The effects of HBO treatment are similar in the aortic tissues. These observations provide evidence that HBO treatment has a powerful effect on the redox state of relevant tissues and produces an environment that inhibits oxidation. The anti-oxidant response may be the key to the anti-atherogenic effect of HBO treatment. PMID:16973170

  20. The adductor magnus &apos;'mini-hamstring'&apos;: MRI appearance and potential pitfalls

    Energy Technology Data Exchange (ETDEWEB)

    Broski, Stephen M.; Murthy, Naveen S.; Collins, Mark S. [Department of Radiology, Mayo Clinic, Rochester, MN (United States); Krych, Aaron J. [Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN (United States); Obey, Mitchel R. [Mayo School of Graduate Medical Education, Rochester, MN (United States)

    2016-02-15

    To examine the anatomic MRI characteristics of the adductor magnus mini hamstring (AMMH) and explore its involvement in cases of hamstring avulsion. An IRB-approved retrospective review of patients undergoing &apos;&apos;hamstring protocol&apos;&apos; MRI between March 2009 and June 2014 was performed. Two musculoskeletal radiologists recorded multiple AMMH anatomic characteristics and involvement in cases of hamstring avulsion. Seventy-six AMMHs were analyzed in 66 patients [35 females and 31 males, mean age 49.3 ± 15.2 years (range 17-81)]. Eleven percent of AMMHs were poorly visualized, 51 % visualized, and 37 % well visualized. Seven percent demonstrated round, 73 % ovoid, and 21 % flat/lenticular tendon morphologies. Most (88 %) demonstrated typical origins. Average cross-sectional area (CSA) was 22.4 ± 10.6 mm{sup 2} (range 6-56), diameter was 7.2 ± 2.5 mm (range 2.9-15), medial distance from the semimembranosus tendon was 7.5 ± 2.5 mm (range 3-14), and tendon length was 6.8 ± 3.3 cm (range 1.2-14.1). There was no gender difference in AMMH anatomic measurements or correlation between age and CSA or diameter. Of 17 complete hamstring avulsion cases, the AMMH was intact in 13, partially torn in 3, and completely torn in 1. The AMMH is a constant finding with variable anatomic characteristics. It is visualized or well visualized by MRI in 88 % of cases and is a sizable tendon located in close proximity to the semimembranosus tendon. Because it is uncommonly completely torn (6 %) in cases of complete hamstring avulsion, radiologists should be aware of its presence and appearance to avoid diagnostic confusion. (orig.)

  1. DIGITALNO MARKETINŠKO KOMUNICIRANJE V PODJETJU SIMOBIL D.D.

    OpenAIRE

    Cajnko, Katja

    2015-01-01

    Digitalni marketing oz. marketinško komuniciranje je relativno nov tehnološki izraz, ki je izbruhnil v svet industrije. Opredelimo ga lahko kot promocijsko izpostavljenost izdelkov ali svetovnih blagovnih znamk skozi eno ali več oblik družbenega mreženja. Povzroča pravi gospodarski razcvet, medtem ko so tradicionalne marketinške metode postale manj dobičkonosne in zastarele ter se v veliki večini osredinjajo samo na televizijske in časopisne oglase. Njegov obstoj ne gre jemati kot luksuzen...

  2. The new steam generators for the Krško nuclear power plant

    OpenAIRE

    Nemčić, Krešimir

    2015-01-01

    This paper presents the new steam generators for the Krško nuclear power plant and describes the main design and fabrication improvements which are an ongoing research and development effort in steam generator technology, aimed at improving the reliability and maintainability of the new steam generators. The paper also provides basic information relating to the manufacturing of the new steam generators. Članek predstavlja nova uparjalnika za JE Krško in opisuje glavne izboljšave projekta i...

  3. Ideality and Reality : The Body as Social Criticism in Tsushima Yûko's Child of Fortune

    OpenAIRE

    2008-01-01

    This thesis is an analysis of the Japanese novel Child of Fortune (Chôji) that was written and published in the late 1970s. The author Tsushima Yûko is relatively unknown to the Western public although she is considered to be one of the more important writers of contemporary Japanese literature. Tsushima Yûko often writes about Japanese women s situation, and she is particularly concerned about issues connected to single motherhood, problems related to pregnancy and child rearing, and the ab...

  4. Advanced RF-KO slow-extraction method for the reduction of spill ripple

    CERN Document Server

    Noda, K; Shibuya, S; Uesugi, T; Muramatsu, M; Kanazawa, M; Takada, E; Yamada, S

    2002-01-01

    Two advanced RF-knockout (RF-KO) slow-extraction methods have been developed at HIMAC in order to reduce the spill ripple for accurate heavy-ion cancer therapy: the dual frequency modulation (FM) method and the separated function method. As a result of simulations and experiments, it was verified that the spill ripple could be considerably reduced using these advanced methods, compared with the ordinary RF-KO method. The dual FM method and the separated function method bring about a low spill ripple within standard deviations of around 25% and of 15% during beam extraction within around 2 s, respectively, which are in good agreement with the simulation results.

  5. Multiphonon method applied to vibrational (K=O) state study in deformed heavy nuclei

    International Nuclear Information System (INIS)

    An explicit formulation of the multiphonon method is given where two phonons are introduced as base. Vibrational states can then be studied in the realistic case of pair deformed heavy-nuclei (plutonium, uranium and thorium isotopes). Localization and properties of two-phonon states are particularly examined. Energy spectra are systematically dilated, octupolar vibrations K=O- show more anharmonicity than the K=O+ ones. The two-phonon states are between 1.7 and 2 MeV; they keep a collective nature by their electromagnetic transitions (E1, E2, E3) towards one-phonon states

  6. DELO Z OTROŠKO VOKALNO SKUPINO 4. RAZREDA OSNOVNE ŠOLE

    OpenAIRE

    Simrajh, Patricija

    2015-01-01

    Pri urah glasbene vzgoje velikokrat ne ostane dovolj časa, da bi se naučeni pesmi posvetili še nekoliko bolje – jo muzikalno interpretirali. Zato lahko na osnovni šoli učitelj razrednega pouka oblikuje otroško vokalno skupino kot interesno dejavnost. Prav zato je nastala diplomska naloga z naslovom Delo z otroško vokalno skupino v 4. razredu osnovne šole. V teoretičnem delu so predstavljena dosedanja znanstvena spoznanja o glasbeno-pevskem razvoju učencev, oblikovanju otroškega glasu in ...

  7. Faktorska struktura kompetetntnosti deinstitucionaliziranih osoba s intelektualnim teškoćama

    OpenAIRE

    Rožman, Bojana; Nikolić, Branko; Bratković, Daniela

    2007-01-01

    S razvojem novih izvaninstitucionalnih oblika skrbi i podrške za osobe s intelektualnim teškoćama postala je vidljiva potreba za kreiranjem i upotrebom instrumenata kojima će se prikupljati podaci o razinama kompetentnosti i potreba za podrškom korisnika programa. U ovom radu korištena je Skala procjene kompetentnosti i potreba za podrškom osoba s intelektualnim teškoćama, koja je izrađena u okviru znanstveno istraživačkog projekta dukacijsko-rehabilitacijskog fakulteta, pod nazivom „Evalu...

  8. Reševanje vodnih izgub vodovoda Laško

    OpenAIRE

    Nemec, Anja

    2013-01-01

    Diplomska naloga obravnava problematiko in možne načine reševanja vodnih izgub vodovoda Laško. V uvodnem delu smo predstavili vodovod Laško in stanje vodnih izgub. V poglavju o prikazu problema smo definirali, zakaj prihaja do izgub in kje so vzroki. Med pomembne dejavnike štejemo tudi zakonodajo, saj brez nje ni uspešnega delovanja na področju obratovanja in vodenja. Danes je obvladovanje vodnih izgub pomemben dejavnik, s katerim se srečujejo vsi upravljavci vodovodnih omrežjih. Te probl...

  9. ORIENTACIJSKA IN NAKLONSKA ODVISNOST FOTONAPETOSTNIH SISTEMOV ŠC KRŠKO - SEVNICA

    OpenAIRE

    Požun, Jože

    2013-01-01

    Magistrska naloga obravnava orientacijsko in naklonsko odvisnost fotonapetostnih sistemov Šolskega centra Krško-Sevnica. Fotonapetostni moduli sončnih elektrarn ŠC Krško-Sevnica so orientirani v smeri vzhod, jug in kot sledilni sistem za namen raziskovanja in izobraževanja. Na podlagi večletnih meritev, opravljenih na sončnih elektrarnah, bo v nalogi ovrednoten vpliv orientacijske in naklonske odvisnosti na proizvodnjo električne energije. Izplen proizvodnje električne energije sončnih elektr...

  10. Neutron activation analysis of trace elements in carbonate rocks by using a ko standardization method

    International Nuclear Information System (INIS)

    The quantitative analysis of the trace element was conducted by the ko method using carbonate rock standard sample JLs-1 (limestone) and JDo-1 (Dolomite), and the effectiveness of the activation analysis with the ko method to the carbonate rock sample was confirmed. The accuracy of the quantitative measurement for the analysis results of long-lived nuclides of Al and Ba, middle-lived nuclides of Sm and Ho, and short-lived nuclides of Ce and Yb was evaluated compared with recommended values of Geological Survey of Japan. (H. Katsuta)

  11. Condoms - male

    Science.gov (United States)

    ... contained in a male's semen reach a woman's vagina, pregnancy may occur. Condoms work by preventing sperm ... coming in contact with the inside of the vagina. If condoms are used correctly every time intercourse ...

  12. &apos;Side-by-side&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2010-07-01

    France is a nuclear power nation. And this is not going to change. However, at the same time, the country is also pursuing massive investments in the expansion of renewable energies. According to France&apos;s President Nicolas Sarkozy, the motto should be: &apos;side-by-side&apos; rather than &apos;one or the other&apos;. For the PV sector, whose success was unbroken during the crisis in 2009, the signal is positive and could mean sustained growth. (orig.)

  13. BLOWIN&apos; IN THE WIND: BOTH &apos;'NEGATIVE'&apos; AND &apos;'POSITIVE'&apos; FEEDBACK IN AN OBSCURED HIGH-z QUASAR

    Energy Technology Data Exchange (ETDEWEB)

    Cresci, G.; Mannucci, F. [INAF-Osservatorio Astrofisco di Arcetri, largo E. Fermi 5, I-50127, Firenze (Italy); Mainieri, V. [European Southern Observatory, Karl-Schwarzschild-strasse 2, D-85748 Garching bei München (Germany); Brusa, M.; Perna, M.; Lanzuisi, G. [Dipartimento di Fisica e Astronomia, Università di Bologna, viale Berti Pichat 6/2, I-40127 Bologna (Italy); Marconi, A. [Dipartimento di Fisica e Astronomia, Università degli Studi di Firenze, via G. Sansone 1, I-50019 Sesto F.no, Firenze (Italy); Piconcelli, E.; Feruglio, C.; Fiore, F.; Bongiorno, A. [INAF-Osservatorio Astronomico di Roma, via Frascati 33, I-00040 Monteporzio Catone (Italy); Maiolino, R. [Cavendish Laboratory, University of Cambridge, 19 J. J. Thomson Avenue, Cambridge (United Kingdom); Merloni, A [Max Planck Institut für Extraterrestrische Physik, Giessenbachstrasse 1, D-85748 Garching bei München (Germany); Schramm, M.; Silverman, J. D. [Kavli Institute for the Physics and Mathematics of the Universe (WPI), Todai Institutes for Advanced Study, the University of Tokyo, Kashiwanoha 5-1-5, Kashiwa-shi, Chiba 277-8568 (Japan); Civano, F., E-mail: gcresci@arcetri.astro.it [Department of Physics and Yale Center for Astronomy and Astrophysics, Yale University, PO Box 208121, New Haven, CT 06520-8121 (United States)

    2015-01-20

    Quasar feedback in the form of powerful outflows is invoked as a key mechanism to quench star formation in galaxies, preventing massive galaxies to overgrow and producing the red colors of ellipticals. On the other hand, some models are also requiring &apos;'positive'&apos; active galactic nucleus feedback, inducing star formation in the host galaxy through enhanced gas pressure in the interstellar medium. However, finding observational evidence of the effects of both types of feedback is still one of the main challenges of extragalactic astronomy, as few observations of energetic and extended radiatively driven winds are available. Here we present SINFONI near infrared integral field spectroscopy of XID2028, an obscured, radio-quiet z = 1.59 QSO detected in the XMM-COSMOS survey, in which we clearly resolve a fast (1500 km s{sup –1}) and extended (up to 13 kpc from the black hole) outflow in the [O III] lines emitting gas, whose large velocity and outflow rate are not sustainable by star formation only. The narrow component of Hα emission and the rest frame U-band flux from Hubble Space Telescope/Advanced Camera for Surveys imaging enable to map the current star formation in the host galaxy: both tracers independently show that the outflow position lies in the center of an empty cavity surrounded by star forming regions on its edge. The outflow is therefore removing the gas from the host galaxy (&apos;&apos;negative feedback&apos;&apos;), but also triggering star formation by outflow induced pressure at the edges (&apos;&apos;positive feedback&apos;&apos;). XID2028 represents the first example of a host galaxy showing both types of feedback simultaneously at work.

  14. BLOWIN&apos; IN THE WIND: BOTH &apos;'NEGATIVE'&apos; AND &apos;'POSITIVE'&apos; FEEDBACK IN AN OBSCURED HIGH-z QUASAR

    International Nuclear Information System (INIS)

    Quasar feedback in the form of powerful outflows is invoked as a key mechanism to quench star formation in galaxies, preventing massive galaxies to overgrow and producing the red colors of ellipticals. On the other hand, some models are also requiring &apos;'positive'&apos; active galactic nucleus feedback, inducing star formation in the host galaxy through enhanced gas pressure in the interstellar medium. However, finding observational evidence of the effects of both types of feedback is still one of the main challenges of extragalactic astronomy, as few observations of energetic and extended radiatively driven winds are available. Here we present SINFONI near infrared integral field spectroscopy of XID2028, an obscured, radio-quiet z = 1.59 QSO detected in the XMM-COSMOS survey, in which we clearly resolve a fast (1500 km s–1) and extended (up to 13 kpc from the black hole) outflow in the [O III] lines emitting gas, whose large velocity and outflow rate are not sustainable by star formation only. The narrow component of Hα emission and the rest frame U-band flux from Hubble Space Telescope/Advanced Camera for Surveys imaging enable to map the current star formation in the host galaxy: both tracers independently show that the outflow position lies in the center of an empty cavity surrounded by star forming regions on its edge. The outflow is therefore removing the gas from the host galaxy (&apos;&apos;negative feedback&apos;&apos;), but also triggering star formation by outflow induced pressure at the edges (&apos;&apos;positive feedback&apos;&apos;). XID2028 represents the first example of a host galaxy showing both types of feedback simultaneously at work

  15. Draft Genome Sequence of the Methanotrophic Gammaproteobacterium Methyloglobulus morosus DSM 22980 Strain KoM1

    OpenAIRE

    Poehlein, Anja; Daniel, Rolf

    2013-01-01

    Here, we report the draft genome sequence of the methanotrophic gammaproteobacterium Methyloglobulus morosus DSM 22980 strain KoM1, which is proposed to be the type species for the novel genus Methyloglobulus. The genome (4.143 Mb) consists of a single circular chromosome and harbors genes for 2-aminoethylphosphonate (ciliatine) biosynthesis.

  16. 1,8-Cineole Ameliorates Steatosis of Pten Liver Specific KO Mice via Akt Inactivation

    Directory of Open Access Journals (Sweden)

    Soichiro Murata

    2015-05-01

    Full Text Available Hepatocyte-specific Phosphatase and tensin homolog (Pten-knockout (KO mice exhibit hepatic lesions analogous to non-alcoholic steatohepatitis (NASH. 1,8-cineole is a monoterpene oxide and it has several biological effects including hepatoprotective effects. In this study we revealed that 1,8-cineole ameliorates NASH of Pten KO mice. Pten KO mice were assigned to a control group without any medication or to a 1,8-cineole group injected with 50 mg/kg i.p. twice per week for eight weeks. At eight weeks, livers from each group were processed to measure triglyceride (TG content, gene expression analysis, western blot analysis, and histological examination including Oil red O staining. 1,8-cineole ameliorated hepatic steatosis in Pten KO mice, revealed by TG content and Oil red O staining. Moreover, 1,8-cineole downregulated collagen 1a1 expression and improved liver fibrosis. Thus, 1,8-cineole has potential as a candidate to treat NASH by inactivating the Akt/PI3-kinase pathway.

  17. [Andreeva, E. and Belobrovtseva, I. "Tol'ko Vy poimete sleduiushchii tekst..."] / Avril Pyman

    Index Scriptorium Estoniae

    Pyman, Avril

    2014-01-01

    Arvustus: Andreeva, E. and Belobrovtseva, I. "Tol'ko Vy poimete sleduiushchii tekst...". Perepiska N. E. Andreeva i L. F. Zurova. Baltiiskii arkhiv: Russkaia kult'tura v Pribaltike, 13. Tallinna Ülikooli Slaavi Keelte ja Kultuuride Instituut, Tallinn, 2013

  18. Öko tähendab edu / Liis Kängsepp

    Index Scriptorium Estoniae

    Kängsepp, Liis, 1981-

    2008-01-01

    Kaubandusturul on populaarsust kogumas mahe- ja ausalt toodetud (fair trade) kaubad. Vt. samas: Mis on mahetoit; Fair Trade; Roheline liikumine: tarbi vähem!; Mätas: pane öko peale ja müüb!; Treener Kristel Tamm jõudis ökoni oma lapsele head pakkuda tahtes

  19. Determination of trace elements in standard reference materials by the ko-standardization method

    International Nuclear Information System (INIS)

    The ko-standardization method is suitable for routine multielement determinations by reactor neutron activation analysis (NAA). Investigation of NIST standard reference materials SRM 1571 Orchard Leaves, SRM 1572 Citrus leaves, and SRM 1573 Tomato Leaves showed the systematic error of 12 certified elements determined to be less than 8%. Thirty-four elements were determined in NIST proposed SRM 1515 Apple Leaves

  20. Elemental profiles of soil in and around Tirupati by reactor neutron activation using KO method

    International Nuclear Information System (INIS)

    Soil samples, representatives of various places in and around Tirupati, Andhra Pradesh, that are affected by industrial effluents and sewages, were analysed for the elemental profiles by neutron activation analysis (NAA) using Ko method. Concentrations of 23 elements were measured. Variation in concentration of important elements with respect to influence on vegetation is discussed. (author). 2 refs., 1 tab

  1. Förderung des Öko-Landbaus - Vom Aschenputtel zum Lieblingskind

    OpenAIRE

    Dabbert, Stephan; Häring, Anna

    2004-01-01

    Nach Jahrzehnten im Schatten der übermächtigen konventionellen Landwirtschaft wird der Öko-Landbau nun von der Politik hofiert und staatlich gefördert. Dafür gibt es gute Gründe - ökologisch und ökonomisch gesehen.

  2. Model validation of GAMMA code with heat transfer experiment for KO TBM in ITER

    International Nuclear Information System (INIS)

    Highlights: ► In this study, helium supplying system was constructed. ► Preparation for heat transfer experiment in KO TBM condition using helium supplying system was progressed. ► To get more applicable results, test matrix was made to cover the condition for KO TBM. ► Using CFD code; CFX 11, validation and modification for system code GAMMA was performed. -- Abstract: By considering the requirements for a DEMO-relevant blanket concept, Korea (KO) has proposed a He cooled molten lithium (HCML) test blanket module (TBM) for testing in ITER. A performance analysis for the thermal–hydraulics and a safety analysis for the KO TBM have been carried out using a commercial CFD code, ANSYS-CFX, and a system code, GAMMA (GAs multicomponent mixture analysis), which was developed by the gas cooled reactor in Korea. To verify the codes, a preliminary study was performed by Lee using a single TBM first wall (FW) mock-up made from the same material as the KO TBM, ferritic martensitic steel, using a 6 MPa nitrogen gas loop. The test was performed at pressures of 1.1, 1.9 and 2.9 MPa, and under various ranges of flow rate from 0.0105 to 0.0407 kg/s with a constant wall temperature condition. In the present study, a thermal–hydraulic test was performed with the newly constructed helium supplying system, in which the design pressure and temperature were 9 MPa and 500 °C, respectively. In the experiment, the same mock-up was used, and the test was performed under the conditions of 3 MPa pressure, 30 °C inlet temperature and 70 m/s helium velocity, which are almost same conditions of the KO TBM FW. One side of the mock-up was heated with a constant heat flux of 0.3–0.5 MW/m2 using a graphite heating system, KoHLT-2 (Korea heat load test facility-2). Because the comparison result between CFX 11 and GAMMA showed a difference tendency, the modification of heat transfer correlation included in GAMMA was performed. And the modified GAMMA showed the strong parity with CFX 11

  3. Switzerland as Europe&apos;s &apos;'battery'&apos;. Wishful dream or reality?

    International Nuclear Information System (INIS)

    There are plans for Swiss pumped hydrostorage systems to absorb large quantities of excess electricity from European wind and solar power generation. Model-based analyses have shown however that &apos;'Europe&apos;s battery&apos;&apos;, as Switzerland would like to see itself, will not be needed until the middle of this century. Even if all extension projects currently in progress should be completed, Switzerland will not have sufficient pump capacity or import capacity to absorb large amounts of excess electricity. Furthermore, the primary means of making storage capacity available for import electricity would be to reduce reservoir power plant capacity. In view of all this Switzerland&apos;s hopes for a role as a major European electricity storage provider appear somewhat exaggerated even in the long-term perspective.

  4. ApoE polymorphisms in narcolepsy

    Directory of Open Access Journals (Sweden)

    Kasten Meike

    2001-08-01

    Full Text Available Summary Background Narcolepsy is a common neuropsychiatric disorder characterized by increased daytime sleepiness, cataplexy and hypnagogic hallucinations. Deficiency of the hypocretin neurotransmitter system was shown to be involved in the pathogenesis of narcolepsy in animals and men. There are several hints that neurodegeneration of hypocretin producing neurons in the hypothalamus is the pathological correlate of narcolepsy. The ApoE4 allele is a major contributing factor to early-onset neuronal degeneration in Alzheimer disease and other neurodegenerative diseases as well. Methods To clarify whether the ApoE4 phenotype predisposes to narcolepsy or associates with an earlier disease onset, we have genotyped the ApoE gene in 103 patients with narcolepsy and 101 healthy controls. Results The frequency of the E4 allele of the ApoE gene was 11% in the patient and 15% in the control groups. Furthermore, the mean age of onset did not differ between the ApoE4+ and ApoE4- patient groups. Conclusion Our results exclude the ApoE4 allele as a major risk factor for narcolepsy.

  5. &apos;&apos;When Cost Measures Contradict&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Montgomery, W. D.; Smith, A. E.; Biggar, S. L.; Bernstein, P. M.

    2003-05-09

    When regulators put forward new economic or regulatory policies, there is a need to compare the costs and benefits of these new policies to existing policies and other alternatives to determine which policy is most cost-effective. For command and control policies, it is quite difficult to compute costs, but for more market-based policies, economists have had a great deal of success employing general equilibrium models to assess a policy&apos;s costs. Not all cost measures, however, arrive at the same ranking. Furthermore, cost measures can produce contradictory results for a specific policy. These problems make it difficult for a policy-maker to determine the best policy. For a cost measures to be of value, one would like to be confident of two things. First one wants to be sure whether the policy is a winner or loser. Second, one wants to be confident that a measure produces the correct policy ranking. That is, one wants to have confidence in a policy measure&apos;s ability to correctly rank policies from most beneficial to most harmful. This paper analyzes empirically these two properties of different costs measures as they pertain to assessing the costs of the carbon abatement policies, especially the Kyoto Protocol, under alternative assumptions about implementation.

  6. Korea&apos;s 1-watt plan &apos;&apos;Standby Korea 2010&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yungrae

    2010-09-15

    Korea announced standby power of all electronics shall be reduced to below 1W by 2010. Ministry of Knowledge Economy (MKE, Korean government) and Korea Energy Management Corporation (KEMCO) established &apos;&apos;Standby Korea 2010&apos;&apos; which is a roadmap to limit standby power below 1W by 2010. Korea implemented mandatory program over a relatively short period of time, incorporating the better elements from the more established national program and adding new initiatives, such as the threat of using mandatory warning label for products that fail to meet standby power targets.

  7. Software in the DOE: The Hidden Overhead of&apos;&apos;The Build&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Kumfert, G; Epperly, T

    2002-02-28

    &apos;&apos;The Build&apos;&apos; is the infrastructure needed to convert software from source code to usable form. It is intimately tied to the software it supports, knowing about every file and automating every transformation needed to produce a working program. Every developer knows that a project spends some labor overhead on &apos;&apos;the build.&apos;&apos; How big is this hidden overhead? According to 34 scientific software developers we surveyed at Lawrence Livermore National Labs, among colleagues at other DOE labs, and a handful of academics the &apos;'perceived'&apos; overhead averages around 12%. Individual cases of 20% to 30% were not uncommon. In one project claiming a 20% overhead, we found supporting evidence by combing through their CVS repository.

  8. Arabidopsis thaliana extracts optimized for polyphenols production as potential therapeutics for the APOE-modulated neuroinflammation characteristic of Alzheimer’s disease in vitro

    Science.gov (United States)

    Ghura, Shivesh; Tai, Leon; Zhao, Ming; Collins, Nicole; Che, Chun-Tao; Warpeha, Katherine M.; LaDu, Mary Jo

    2016-01-01

    Although the cause of Alzheimer’s disease (AD) is unknown, glial-induced neuroinflammation is an early symptom. Familial AD is caused by increases in amyloid-beta (Aβ) peptide, particularly soluble oligomeric (oAβ), considered a proximal neurotoxin and neuroinflammatory stimuli. APOE4, a naturally occurring genotype of APOE, is the greatest genetic risk factor for AD; increasing risk up to 12-fold compared to APOE3 and APOE2. oAβ-induced neuroinflammation is greater with APOE4 compared to APOE3 and APOE2. As sinapates and flavonoids have anti-inflammatory properties, a protocol was developed for optimizing polyphenol production in seedlings of Arabidopsis thaliana (A. thaliana). Three mutants (cop1, prn1, xpf3) were identified, and the extracts treated with liver microsomes to mimic physiological metabolism, with HPLC and MS performed on the resulting metabolites for peak identification. These extracts were used to treat primary glial cells isolated from human APOE-targeted-replacement (APOE-TR) and APOE-knock-out (KO) mice, with neuroinflammation induced by lipopolysaccharide (LPS) or oAβ. The dose-response data for TNFα secretion demonstrate the followed the order: APOE-KO > APOE4 > APOE3 > APOE2, with xpf3 the most effective anti-neuroinflammatory across APOE genotypes. Thus, the plant-based approach described herein may be particularly valuable in treating the APOE4-induced neuroinflammatory component of AD risk. PMID:27383500

  9. A &apos;'LIGHT'&apos;, CENTRALLY CONCENTRATED MILKY WAY HALO?

    Energy Technology Data Exchange (ETDEWEB)

    Rashkov, Valery; Pillepich, Annalisa; Deason, Alis J.; Madau, Piero [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Rockosi, Constance M. [Department of Astronomy and Astrophysics, UCO/Lock Observatory, University of California, Santa Cruz, CA 95064 (United States); Guedes, Javiera [Institute for Astronomy, ETH Zurich, 8093 Zurich (Switzerland); Mayer, Lucio [Institute of Theoretical Physics, University of Zurich, CH-9057 Zurich (Switzerland)

    2013-08-20

    We discuss a novel approach to &apos;'weighing'&apos; the Milky Way (MW) dark matter halo, one that combines the latest samples of halo stars selected from the Sloan Digital Sky Survey (SDSS) with state of the art numerical simulations of MW analogs. The fully cosmological runs employed in the present study include &apos;'Eris'&apos;, one of the highest resolution hydrodynamical simulations of the formation of a M{sub vir} = 8 Multiplication-Sign 10{sup 11} M{sub Sun} late-type spiral, and the dark-matter-only M{sub vir} = 1.7 Multiplication-Sign 10{sup 12} M{sub Sun} &apos;&apos;Via Lactea II&apos;&apos; (VLII) simulation. Eris provides an excellent laboratory for creating mock SDSS samples of tracer halo stars, and we successfully compare their density, velocity anisotropy, and radial velocity dispersion profiles with the observational data. Most mock SDSS realizations show the same &apos;&apos;cold veil&apos;&apos; recently observed in the distant stellar halo of the MW, with tracers as cold as {sigma}{sub los} Almost-Equal-To 50 km s{sup -1} between 100 and 150 kpc. Controlled experiments based on the integration of the spherical Jeans equation as well as a particle tagging technique applied to VLII show that a &apos;'heavy'&apos; M{sub vir} Almost-Equal-To 2 Multiplication-Sign 10{sup 12} M{sub Sun} realistic host produces a poor fit to the kinematic SDSS data. We argue that these results offer added evidence for a &apos;'light'&apos;, centrally concentrated MW halo.

  10. Hybrid seed production in detergent induced male sterile Helianthus annuus L.

    OpenAIRE

    Tripathi S.M.; Singh K.P.

    2008-01-01

    Efficacy of a synthetic detergent &apos;Surf Excel&apos; as a potential male gametocide in Helianthus annuus was evaluated. Foliar applications of three concentrations of &apos;Surf Excel&apos; solution (1.0, 2.0 and 3.0% w/v) at different plant development stages caused reduction in plant height, pollen fertility, total yield/ plant, 100-seed weight and brought about early flowering in comparison with control plants. All treatments with &apos;Surf Exce...

  11. AREVA &apos;&apos;Sustainable Cycle Solutions&apos;&apos;

    International Nuclear Information System (INIS)

    Almost three years after the Fukushima events, the nuclear industry has shown its capacity to respond to first additional safety requirements and continues working closely with the regulators and involved stakeholders for further improvements. Continued growth is still anticipated and several international organizations have confirmed 2035 scenarios close to or above 600 GWe of installed nuclear capacity. Securing and optimizing the fuel cycle is crucial to ensure the sustainability of such a nuclear program in the medium term. Rethinking fuel cycle schemes is also decisive to prepare long term transitions to next generations of reactors. R&D and Innovation shall remain a cornerstone of this sustainable development. Countries with significant or growing nuclear fleets have confirmed their commitment or plans to recycle. This is notably the case in China, France, India, Japan, the Netherlands, South Korea, and the Russian federation. Most of other nuclear countries are currently rethinking their used fuel management, taking into account; the geopolitical context and the international framework, including multilateral agreements, the legacy of their past fuel cycle policies,the cornerstones of energy policies&apos; evolution such as the targets set for energy independence, as well as the level of their ambition in terms of nuclear park evolution, the involvement of concerned stakeholders in the decision making process, the regulatory and legal frameworks evolutions, the operational challenges that the nuclear actors are currently facing, in particular the increasing Constraints related to reactor pool storage, or to very long term dry storage. With the foreseen nuclear development, the used fuel backlog will continue to grow for several decades. Bolstered by a 40 years experience, recycling has been contributing to further increase safety while offering main operational, environmental, global acceptance benefits, among others However even though recycling

  12. Rapporteurs&apos; Report

    Energy Technology Data Exchange (ETDEWEB)

    Isaacs, T H

    2004-02-11

    This Third FSC workshop focused on, &apos;&apos;Understanding the factors that influence public perception and confidence in the area of radioactive waste management...&apos;&apos; The workshop was held in Finland in close cooperation with Finnish stakeholders. This was most appropriate because of the recent successes in achieving positive decisions at the municipal, governmental, and Parliamentary levels, allowing the Finnish high-level radioactive waste repository program to proceed, including the identification of a proposed site. The workshop objective was to gain insight in answering the question, &apos;&apos;How did this political and societal decision come about?&apos;&apos;

  13. About the &apos;&apos;end of the cheap petroleum&apos;&apos;; A propos de la &apos;&apos;fin du petrole bon marche&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    This paper analyses the catastrophic scenario presented by two geologists on the end of a cheap petroleum in the next ten years (paper presented in the french magazine &apos;&apos;Pour la Science&apos;&apos; in may 1998). The authors analysis is more moderate and bring the attention on other arguments as the geo-political and environmental aspects of the problems. (A.L.B.)

  14. Heavy metal characteristics in Kočani Field soil-plant system (Republic of Macedonia)

    Science.gov (United States)

    Rogan Šmuc, Nastja; Dolenec, Tadej; Serafimovski, Todor; Tasev, Goran; Dolenec, Matej; Komar, Darja; Vrhovnik, Petra

    2014-05-01

    Contamination of soils with heavy metals is globally widespread and induces a long-term risk to ecosystem health. This research focuses on the heavy metal contamination, transfer values and health risk assessment in the Kočani Field soil-plant system (Republic of Macedonia). To identify the heavy metal concentrations in Kočani soils and crops (rice and maize) the geochemical analysis were performed by inductive coupled plasma mass spectrometer (ICP-MS), thereupon the transfer factor (TF) and estimated daily intake amount (EDIA) values in Kočani crops were calculated. Heavy metal contamination status of Kočani soils was also assessed by using sequential extraction procedure and by several environmental indexes: geoaccumulation index, contamination factor and contamination degree. The detected total concentrations of As, Cu, Cd, Pb and Zn in soil samples were highly above the threshold values considered to be phytotoxically excessive for the surface soils. The results of the applied indexes confirmed a very high contamination status for Kočani soils. According to the sum of the water soluble (1) and exchangeable (2) fractions for Ag, As, Cd, Cu, Mo, Ni, Pb, Sb and Zn measured in the soils, the mobility and bioavailability potential of the heavy metals studied declined in the following order: Cd > Mo > Sb > Zn > Cu > As > Pb > Ni > Ag. The highest As, Cd, Mo, Pb and Zn values were determined in the rice samples grown in the paddy fields near the Zletovska River. The highest Pb and Mo concentrations measured in the maize samples were from the maize fields near the Zletovska River and Ciflik city. High transfer factor values for Mo, Zn, Cd and Cu revealed a strong accumulation of Mo, Zn and Cd by rice and Mo and Zn by maize crops. The results of the estimated dialy intake showed that the regular consumption of rice and maize crops containing the highest Cd, Mo, Pb and Zn concentrations could pose a serious threat to human health, because the daily intake of Cd, Mo

  15. Poboljšana topljivost teško topljivog lijeka u čvrstim disperzijama s polimernim i nepolimernim hidrofilnim dodacima

    OpenAIRE

    CHAWLA, GARIMA; K. BANSAL, ARVIND

    2008-01-01

    Irbesartan (IBS) je hidrofobni lijek teško topljiv u vodi koji se slabo oslobađa iz ljekovitih pripravaka. U radu je opisana priprava čvrstih disperzija (SDs) IBS-a pomoću aditiva male relativne molekulske mase (vinska kiselina i manitol) i polimera (polivinilpirolidona, PVP, i hidroksipropil metilceluloze, HPMC). Koristeći vinsku kiselinu i PVP topljivost je povećana 9,5 puta (138 g mL1), odnosno 7 puta (103 g mL1) u odnosu na kristaliničnu formu (14,6 g mL1). Difrakcijom X-zrakama pra...

  16. The studies for application of Ko-standardization method of neutron activation analysis on Dalat reactor

    International Nuclear Information System (INIS)

    The studies for application of the Ko-NAA method have been carried out in order to aim at creating a concrete procedure of the method, which is able to apply for practical samples. The results of the calibration of neutron spectrum parameters at cell 7-1, 13-2 and rotary rack on Dalat reactor, the calibration of detection efficiency of gamma spectrometers, the application and development of computer software for processing of gamma-ray spectra and for calculating of related problems (i.e. detector efficiency, neutron spectrum parameters, elemental concentration, etc.) and the quality control/assessment (QC/QA) with the analysis of the reference material IAEA-Soil7 have been presented as well as the application of the ko-NAA for practical samples in geological, archaeological, bio-medical and environmental objects has also been shown. (author)

  17. Neke poteškoće u provedbi radnje prikrivenog istražitelja

    OpenAIRE

    Karas, Željko

    2012-01-01

    Autor u radu analizira neke poteškoće vezane uz taktiku provođenja posebne dokazne radnje prikrivenog istražitelja, temeljeći se na najznačajnijim znanstvenim istraživanjima iz stranih sustava u kojima je zbog blažih zakonskih uvjeta ova radnja znatno učestalija. Cilj rada je prikazati područja u kojima kod prikrivenog djelovanja postoje značajne razlike u odnosu na klasične dokazne radnje i slijedom toga istaknuti potrebu uvažavanja poteškoća koje utječu na otkrivačke i dokazne mogućnosti ra...

  18. Oxidative Stress, Skin Aging and Antioxidant Therapy / Oksidacioni Stres, Starenje Kože I Antioksidaciona Terapija

    OpenAIRE

    Stojiljković Dragana; Pavlović Dušica; Arsić Ivana

    2014-01-01

    Starenje kože je dinamičan proces koji se dešava usled hronološkog starenja i foto-starenja izazvanog izlaganjem delovanju faktora spoljašnje sredine, pre svega UV (eng. ultraviolet) zračenja. Kumulativni oksidacioni stres, formiranje slobodnih radikala i njihov nepovoljan uticaj na biološke sisteme u ćelijama kože, predstavljju čest i zajednički mehanizam oba procesa starenja kože. Formirane reaktivne kiseonične vrste (eng. reactive oxygen species-ROS) mogu dovesti do oksidacije gradivnih mo...

  19. Heavy metal characteristics in Kočani Field plant system (Republic of Macedonia)

    OpenAIRE

    Rogan Šmuc, Nastja; Dolenec, Tadej; Serafimovski, Todor; Tasev, Goran; Dolenec, Matej; Vrhovnik, Petra

    2012-01-01

    Heavy metal contamination of soils is widespread and induces a long-term risk to ecosystem health. This research focuses on the heavy metal contamination, transfer values and risk assessment in the Kočani Field plant system (Republic of Macedonia). To identify the heavy metal concentrations in Kocˇani crops (rice and maize), the geochemical analysis was performed by inductive coupled plasma mass spectrometer and thereupon the transfer factor (TF) and estimated daily...

  20. Monitoring environmental pollution by ko-INAA for environmental protection in Indonesia

    International Nuclear Information System (INIS)

    Regarding to the 2005-2007FNCA program decided, the NAA technique based on the ko-method has been used to determine a concentration of pollutant as function of time and location. This program carries out to monitor a pollutant in the marine environmental sample. Marine samples of sediment, seawater and a clamp, as well as, a green oyster collected from a selected location at north of Banten province and the Bay of Jakarta. Sampling have been carried out twice a year. For background, same sample have been collected at the sampling point located at south-west of Banten. Sediment and biota sample were prepared for NAA determination, meanwhile seawater have been prepared for polarographic measurement. Marine Sediment and biota samples, as well as flux monitor, have been irradiated at a rabbit system facility of RSG GA Siwabessy reactor with a thermal neutron flux of about 2.6.10+17 n.m-2.s-1. Identification of (n, γ) reaction product has been done using a high resolution HPGe detector coupled to a multichannel analyzer. Analysis of γ-ray emitted by activation product have been done using Hyperlab software, while the elemental quantitative analysis have been done by the ko-INAA procedure using ko-IAEA software. The analytical quality was controlled by use of certified reference material of NIST 2702 Marine Sediment, SRM NIST 1566b Oyster Tissue, crm NMIJ 7302a Sediment and CRM No. 9 Sargasso. As preliminary result, the numbers of interested elements in sediments samples were determined to be of about 20 and should be presented in this workshop. Some results of ko-INAA assessment will also be reported and discussed. (author)

  1. Revisiting T2KK and T2KO physics potential and $\

    CERN Document Server

    Hagiwara, Kaoru; Okamura, Naotoshi; Takaesu, Yoshitaro

    2016-01-01

    We revisit the sensitivity study of the Tokai-to-Kamioka-and-Korea (T2KK) and Tokai-to-Kamioka-and-Oki (T2KO) proposals where a water Cerenkov detector with the 100 kton fiducial volume is placed in Korea ($L = 1000$ km) and Oki island ($L = 653$ km) in Japan, respectively, in addition to the Super-Kamiokande for determination of the neutrino mass hierarchy and leptonic CP phase ($\\delta_{CP}$). We systematically study the running ratio of the $\

  2. Decellularized GGTA1-KO pig heart valves do not bind preformed human xenoantibodies.

    Science.gov (United States)

    Ramm, Robert; Niemann, Heiner; Petersen, Björn; Haverich, Axel; Hilfiker, Andres

    2016-07-01

    Pre-clinical and clinical data have unequivocally demonstrated the usefulness of decellularized heart valve (HV) matrices implanted for HV replacement therapy. However, human donor valves applicable for decellularization are in short supply, which prompts the search for suitable alternatives, such as porcine grafts. Since decellularization might be insufficient to remove all xenoantigens, we analysed the interaction of human preformed antibodies with decellularized porcine HV in vitro to assess potential immune reactions upon implantation. Detergent-decellularized pulmonary HV from German Landrace wild-type (wt) or α1,3-galactosyltransferase knockout (GGTA1-KO) pigs were investigated by inhibition ELISA and GSL I-B4 staining to localize and quantify matrix-bound αGal epitopes, which represent the most prominent xenoantigen. Additionally, preformed human xenoantibodies were affinity purified by perfusing porcine kidneys. Binding of purified human antibodies to decellularized HV was investigated by inhibition ELISA. Furthermore, binding of human plasma proteins to decellularized matrices was determined by western blot. Decellularized human pulmonary artery served as controls. Decellularization of wt HV led to a reduction of αGal epitopes by 70 %. Residual epitopes were associated with the subendothelial extracellular matrix. As expected, no αGal epitopes were found on decellularized GGTA1-KO matrix. The strongest binding of preformed human anti-pig antibodies was found on wt matrices, whereas GGTA1-KO matrices bound similar or even fewer xenoantibodies than human controls. These results demonstrate the suitability of GGTA1-KO pigs as donors for decellularized heart valves for human patients. Besides the presence of αGal antibodies on decellularized heart valves, no further preformed xenoantibodies against porcine matrix were detected in tested human sera. PMID:27154491

  3. Cultural and social activity in the municipality of Kočevje during the 1970s

    OpenAIRE

    Natalija Mihelčić

    2013-01-01

    The paper deals with the state of cultural and social production in the municipality of Kočevje during the 1970s. The emphasis is on the presentation of types of cultural and social activity in the municipality, its extent and importance in the urban environment. Amateur cultural activity in the municipality was strongly developed in the third stage of socialism, but nevertheless curtailed due to numerous difficulties and circumstances in which it existed.

  4. Aging of tubes in the Krško nuclear power plant's steam generators

    OpenAIRE

    Cizelj, Leon; Androjna, Ferdo

    2015-01-01

    The paper reviews the domestic efforts devoted to the safe and reliable operation of the Krško nuclear power plant (NPP) at full power, close to the design limit of the steam generators (18% of plugged tubes) for a full decade. This includes an overview of the recent status and history of the degradation processes, discussion of repair criteria, defining the acceptable size of defects and selected results from safety analyses supporting the operation of degraded steam generator (SG) tubes. It...

  5. &apos;Femoral head necrosis&apos; in metabolic and hormonal osteopathies

    Energy Technology Data Exchange (ETDEWEB)

    Heuck, F.H.W.; Treugut, H.

    1984-07-01

    The pathogenesis of bone necrosis is discussed with special attention and with respect to metabolic, hormonal, and vascular factors. The influence of statics and dynamics of the hip joint bones for the development of aseptic necrosis are discussed. 45 patients with &apos;&apos;idiopathic femoral head necroses&apos;&apos; were observed, including 6 cases of renal osteopathy following renal transplantation and immune suppression therapy, 14 cases of long term corticoid therapy, and 11 cases of liver diseases of different genesis. The femoral head necrosis understood as complication of an osteopathy. In our patients there were 31 males and 14 females - which means higher involvement of males. Plain radiological findings and CT-findings of changes of the femoral heat structure in different stages of the disease are described. Early diagnosis of metabolic and hormonal osteopathies is demanded for a joint keeping therapy of the beginning femoral head necrosis. 90 refs.

  6. The experiences to improve plant performance and reliability of Ko-Ri nuclear power plants

    International Nuclear Information System (INIS)

    This paper provides a discussion of the lessons learned from operational experience and the future plans to improve performance of the Ko-Ri plant. To operate nuclear power plants safely with good performance is the only way to mitigate the negative image of nuclear power generation to the public and to enhance the economical benefit compared to other electrical generation method. Therefore, in a continuous effort to overcome a negative challenge from outside, we have driven an aggressive 'OCTF' campaign as part of safety. As a result of our efforts, the following remarkable achievements have been accomplished. (1) 3 times of OCTF during recent three years (2) Selected twice as a top notch power plant on the list of NEI magazine in terms of plant capacity factor (3) No scram recorded in 1997 for all 4 units at Ko-Ri site. Ko-Ri is now undergoing the large scale plant betterment projects for retaking-off our operating performance to the level of new challenge target. Such improvement of critical components in the reactor coolant system and turbine system greatly contribute to increase the safety and reliability of the plant and to shortening of the planned outage period as well as to reduction of radiation exposure and radwaste. (Cho, G. S.). 5 tabs., 10 figs

  7. KoBaMIN: a knowledge-based minimization web server for protein structure refinement.

    Science.gov (United States)

    Rodrigues, João P G L M; Levitt, Michael; Chopra, Gaurav

    2012-07-01

    The KoBaMIN web server provides an online interface to a simple, consistent and computationally efficient protein structure refinement protocol based on minimization of a knowledge-based potential of mean force. The server can be used to refine either a single protein structure or an ensemble of proteins starting from their unrefined coordinates in PDB format. The refinement method is particularly fast and accurate due to the underlying knowledge-based potential derived from structures deposited in the PDB; as such, the energy function implicitly includes the effects of solvent and the crystal environment. Our server allows for an optional but recommended step that optimizes stereochemistry using the MESHI software. The KoBaMIN server also allows comparison of the refined structures with a provided reference structure to assess the changes brought about by the refinement protocol. The performance of KoBaMIN has been benchmarked widely on a large set of decoys, all models generated at the seventh worldwide experiments on critical assessment of techniques for protein structure prediction (CASP7) and it was also shown to produce top-ranking predictions in the refinement category at both CASP8 and CASP9, yielding consistently good results across a broad range of model quality values. The web server is fully functional and freely available at http://csb.stanford.edu/kobamin. PMID:22564897

  8. REŠEVANJE MEDNARODNEGA INVESTICIJSKEGA SPORA MED SLOVENIJO IN HRVAŠKO, GLEDE NUKLEARNE ELEKTRARNE KRŠKO PRED MEDNARODNIM CENTROM ZA REŠEVANJE INVESTICIJSKIH SPOROV-ICSID

    OpenAIRE

    Rola, Nataša

    2014-01-01

    V svoji diplomski nalogi proučujem mednarodni investicijski spor med Republiko Slovenijo in Republiko Hrvaško, ki je poteka glede skupnega objekta Nuklearne elektrarne Krško. V okviru zastavljenega problema, sem se najprej lotila predstavitve Mednarodnega centra za reševanje mednarodnih investicijskih sporov, pred katerim se je spor odvijal. Predstavila sem njegovo organizacijo, strukturo, prednosti, ter posebnosti reševanja investicijskih sporov pred tem mednarodnim telesom. V nadaljevanju s...

  9. Science closes in on the &apos;&apos;Holy Grail&apos;&apos; of solar energy

    Energy Technology Data Exchange (ETDEWEB)

    One of nature&apos;s best kept secrets &apos;&apos;how green plants and algae turn sunlight into useful energy&apos;&apos; is discussed. The work of Arizona State University chemists Devens Gust and Thomas Moore in the area of photosynthesis is described. The ultimate photochemical battery may be years away, but it was only seven years ago that these two scientists began working on a model that will someday make it possible.

  10. KoFlux: Korean Regional Flux Network in AsiaFlux

    Science.gov (United States)

    Kim, J.

    2002-12-01

    AsiaFlux, the Asian arm of FLUXNET, held the Second International Workshop on Advanced Flux Network and Flux Evaluation in Jeju Island, Korea on 9-11 January 2002. In order to facilitate comprehensive Asia-wide studies of ecosystem fluxes, the meeting launched KoFlux, a new Korean regional network of long-term micrometeorological flux sites. For a successful assessment of carbon exchange between terrestrial ecosystems and the atmosphere, an accurate measurement of surface fluxes of energy and water is one of the prerequisites. During the 7th Global Energy and Water Cycle Experiment (GEWEX) Asian Monsoon Experiment (GAME) held in Nagoya, Japan on 1-2 October 2001, the Implementation Committee of the Coordinated Enhanced Observing Period (CEOP) was established. One of the immediate tasks of CEOP was and is to identify the reference sites to monitor energy and water fluxes over the Asian continent. Subsequently, to advance the regional and global network of these reference sites in the context of both FLUXNET and CEOP, the Korean flux community has re-organized the available resources to establish a new regional network, KoFlux. We have built up domestic network sites (equipped with wind profiler and radiosonde measurements) over deciduous and coniferous forests, urban and rural rice paddies and coastal farmland. As an outreach through collaborations with research groups in Japan, China and Thailand, we also proposed international flux sites at ecologically and climatologically important locations such as a prairie on the Tibetan plateau, tropical forest with mixed and rapid land use change in northern Thailand. Several sites in KoFlux already begun to accumulate interesting data and some highlights are presented at the meeting. The sciences generated by flux networks in other continents have proven the worthiness of a global array of micrometeorological flux towers. It is our intent that the launch of KoFlux would encourage other scientists to initiate and

  11. Oxidative Stress, Skin Aging and Antioxidant Therapy / Oksidacioni Stres, Starenje Kože I Antioksidaciona Terapija

    Directory of Open Access Journals (Sweden)

    Stojiljković Dragana

    2014-12-01

    Full Text Available Starenje kože je dinamičan proces koji se dešava usled hronološkog starenja i foto-starenja izazvanog izlaganjem delovanju faktora spoljašnje sredine, pre svega UV (eng. ultraviolet zračenja. Kumulativni oksidacioni stres, formiranje slobodnih radikala i njihov nepovoljan uticaj na biološke sisteme u ćelijama kože, predstavljju čest i zajednički mehanizam oba procesa starenja kože. Formirane reaktivne kiseonične vrste (eng. reactive oxygen species-ROS mogu dovesti do oksidacije gradivnih molekula ćelija. Peroksidacija lipida, oštećenje membranskih proteina i DNK mutacije mogu dovesti do pojave strukturnih, funkcionalnih, kao i estetskih promena na koži, a takođe mogu pokrenuti razvoj mnogih bolesti.

  12. Sunce i koža – što moramo znati za pravilnu zaštitu?

    OpenAIRE

    Bakija-Konsuo, Ana

    2014-01-01

    Sunce je izvor života, ali danas se zna da pretjerano izlaganje suncu dovodi do imunosupresije, ubrzanog starenja kože, kao i tumora kože. Kada se govori o neželjenim učincima sunčevog svjetla na kožu najvažnije su ultraljubičaste zrake, ali se u novije vrijeme sve više govori i o neželjenim učincima infracrvenih zraka, kao i vidljivog svjetla. U radu će se istaknuti najvažnije činjenice o sunčevom svjetlu i njegovim učincima na kožu, mjerama pravilne zaštite te o ulozi vitamina D i antioksid...

  13. A HYDRODYNAMICAL SOLUTION FOR THE &apos;'TWIN-TAILED'&apos; COLLIDING GALAXY CLUSTER &apos;&apos;EL GORDO&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Molnar, Sandor M. [Department of Physics, National Taiwan University, Taipei 10617, Taiwan (China); Broadhurst, Tom, E-mail: sandor@phys.ntu.edu.tw [Department of Theoretical Physics, University of the Basque Country, E-48080 Bilbao (Spain)

    2015-02-10

    The distinctive cometary X-ray morphology of the recently discovered massive galaxy cluster &apos;&apos;El Gordo&apos;&apos; (ACT-CT J0102–4915; z = 0.87) indicates that an unusually high-speed collision is ongoing between two massive galaxy clusters. A bright X-ray &apos;'bullet'&apos; leads a &apos;'twin-tailed'&apos; wake, with the Sunyaev-Zel&apos;dovich (SZ) centroid at the end of the northern tail. We show how the physical properties of this system can be determined using our FLASH-based, N-body/hydrodynamic model, constrained by detailed X-ray, SZ, and Hubble lensing and dynamical data. The X-ray morphology and the location of the two dark matter components and the SZ peak are accurately described by a simple binary collision viewed about 480 million years after the first core passage. We derive an impact parameter of ≅300 kpc, and a relative initial infall velocity of ≅2250 km s{sup –1} when separated by the sum of the two virial radii assuming an initial total mass of 2.15 × 10{sup 15} M {sub ☉} and a mass ratio of 1.9. Our model demonstrates that tidally stretched gas accounts for the northern X-ray tail along the collision axis between the mass peaks, and that the southern tail lies off axis, comprising compressed and shock heated gas generated as the less massive component plunges through the main cluster. The challenge for ΛCDM will be to find out if this physically extreme event can be plausibly accommodated when combined with the similarly massive, high-infall-velocity case of the Bullet cluster and other such cases being uncovered in new SZ based surveys.

  14. X-ray fluorescence analysis of the Venus rocks by the &apos;&apos;Venera-13&apos; and &apos;&apos;Venera-14&apos;&apos; space probes

    Energy Technology Data Exchange (ETDEWEB)

    Surkov, Yu.A.; Shcheglov, O.P.; Moskaleva, L.P.; Kirichenko, V.S.; Dudin, A.D.; Gimadov, V.L.; Kurochkin, S.S.; Rasputnyj, V.N. (AN SSSR, Moscow. Inst. Geokhimii i Analiticheskoj Khimii)

    1982-08-01

    The device and X-ray measurement technique, used for the elemental analysis of Venerus&apos; rocks by the &apos;&apos;Venera-13&apos;&apos; and &apos;&apos;Venera-14&apos;&apos; space probes, are described. The X-ray fluorescence spectrometer device, characteristics of Fe/sup 55/ and Pu/sup 238/ radioisotope sources, used in the device, the proportional counter and the structural flowsheet of the pulse amplitude analyzer, is briefly represented. Venerus&apos; rock is sampled by a special coring tool, transported through the sluice port into the lander and irradiated by radioisotope sources. The excited fluorescence is recorded by a 256-channel spectrometer. The information is transmitted to the Earth telemetrically. The devices of both landers operate reliably. The chemical composition of the rock samples is determined as a result of these experiments.

  15. 沉默Ko70基因逆转人乳腺癌耐药细胞MCF-7/ADR耐药性%Silence Ko70 gene inverted MCF7/ADR drug resistence to cisplatin

    Institute of Scientific and Technical Information of China (English)

    葛亮; 佟倜; 李欣蓉; 崔雪玲; 陈芳芳

    2013-01-01

    目的 探讨沉默Ko70基因对耐表阿霉素人乳腺癌细胞MCF-7/ADR耐药逆转作用.方法 以脂质体包裹的SiRNA-Ko70转染细胞,RT-PCR验证KO70沉默效率.CCK8试剂盒测定细胞增殖活性,通过Caspase-3分光光度法、Annexin Ⅴ-PI染色检测细胞凋亡.结果 SiRNA-KO70转染组Ko70-mRNA表达明显下降,细胞对表阿霉素的敏感性明显增加,药物半数致死浓度(IC50)由34.38±6.75 μg/ml降低为13.06±2.62 μg/ml,耐药指数(RI)由8.26减至3.14.以表阿霉素5 μg/ml的培养液培养细胞24 h,SiRNA-Ko70转染组(12 pmol)与阴性对照组及空白对照组相比,caspase-3活性明显增高;凋亡细胞数明显增多.结论 SiRNA-Ko70通过下调Ko70的表达,逆转耐表阿霉素人乳腺癌细胞MCF-7/ADR对表阿霉素的耐药性,降低凋亡域值,从而增强了人乳腺癌细胞对表阿霉素的敏感性.%Objective To explore whether silence Ko70 protein can reverse the resistance of the cpirubicin-rcsistant human breast cancer cell MCF-7/ADR to cpirubicin. Methods Transfcctcd SiRNA-Ko70 into MCF7/ADR via liposomc, RT-PCR validated the silent efficiency of Ko70. CCK8 kit to determine the cells proliferation activity, Anncxin V-PI staining and Caspasc-3 kit to detect cells apoptosis. Results SiRNA-Ko70 transfection decreased Ko70-mRNA expression significantly and increased the sensitivity of MCF7/ADR to cpirubicin, drug median lethal Concentration (IC50) decreased from 34. 38 + 6. 75 μg/ml to 13. 06 i 2. 62 μg/ml,rcsistantindcx (RI) decreased from 8. 26 to 3. 14. caspasc-3 activity and the number of apoptotic cells of SiRNA-Ko70 transfection group (12 pmol) increased significantly compared with the negative control group and blank control group after cultured with 5 μg/ml cpirubicin for 24 hours. Conclusion Down regulation of Ko70 could reverse drug resistance to cpirubicin in human breast cancer cell MCF-7/ADR, reduce apoptosis domain value of MCF-7/ADR and enhance sensitivity of the human breast cancer

  16. Binding Specificities of the Telomere Phage ϕKO2 Prophage Repressor CB and Lytic Repressor Cro.

    Science.gov (United States)

    Hammerl, Jens Andre; Jäckel, Claudia; Lanka, Erich; Roschanski, Nicole; Hertwig, Stefan

    2016-01-01

    Temperate bacteriophages possess a genetic switch which regulates the lytic and lysogenic cycle. The genomes of the temperate telomere phages N15, PY54, and ϕKO2 harbor a primary immunity region (immB) comprising genes for the prophage repressor (cI or cB), the lytic repressor (cro) and a putative antiterminator (q). The roles of these products are thought to be similar to those of the lambda proteins CI (CI prophage repressor), Cro (Cro repressor), and Q (antiterminator Q), respectively. Moreover, the gene order and the location of several operator sites in the prototype telomere phage N15 and in ϕKO2 are reminiscent of lambda-like phages. We determined binding sites of the ϕKO2 prophage repressor CB and lytic repressor Cro on the ϕKO2 genome in detail by electrophoretic mobility shift assay (EMSA) studies. Unexpectedly, ϕKO2 CB and Cro revealed different binding specificities. CB was bound to three OR operators in the intergenic region between cB and cro, two OL operators between cB and the replication gene repA and even to operators of N15. Cro bound exclusively to the 16 bp operator site OR3 upstream of the ϕKO2 prophage repressor gene. The ϕKO2 genes cB and cro are regulated by several strong promoters overlapping with the OR operators. The data suggest that Cro represses cB transcription but not its own synthesis, as already reported for PY54 Cro. Thus, not only PY54, but also phage ϕKO2 possesses a genetic switch that diverges significantly from the switch of lambda-like phages. PMID:27527206

  17. &apos;&apos;Social capitalism&apos;&apos; in renewable energy generation: China and California comparisons

    Energy Technology Data Exchange (ETDEWEB)

    Clark, Woodrow W. II.; Li, Xing [Clark Strategic Partners, PO Box 17975, Beverly Hills, CA 90210 (United States)

    2010-03-15

    With a population of over 1.3 billion people, demand for renewable energy is expected to grow to a USD $12 billion market in the near term. Under Renewable Energy Law (REL) in February 2005 in the People&apos;s Republic of China (PRC) passed by the National Congress, renewable energy projects will be able to receive a range of financial incentives starting in 2006, which will more than double the PRC current renewable energy generation from 7% to 15% by 2020. Most of the increase will be in hydroelectric generated power. Nonetheless, the nation and especially the provinces are moving rapidly to develop a wide range of renewable energy generation including solar, wind, geothermal and run of the river. Because China practices &apos;&apos;social capitalism&apos;&apos; as expressed in it&apos;s recurrent Five Year National Plans since 1999, the national government and all the provinces have programs, unlike many western and industrialized nations, to &apos;'plan'&apos; and provide for infrastructures. This paper concerns only the energy infrastructure sector and renewable energy generation in particular. The planning process includes financial incentives and investments which are a major part of the Chinese law focused on &apos;&apos;encouraging foreign investment industries&apos;&apos;. The key part of the law is to guarantee long-term power purchase agreements with state owned and controlled &apos;'utilities'&apos;. In short, China may have gotten the economics of the energy sector correct in its concern for planning and finance. The paper develops these energy infrastructure ideas along with the legal and financial requirements as &apos;'lessons'&apos; learned from the USA and especially California. These lessons now apply to China and allow it to learn from the American mistakes. Empirical data will be drawn from work done in China that examine the renewable energy generation and infrastructures and hence allow the RPC and its

  18. &apos;'Routine'&apos; brain CT in psychiatric patients - does it make sense?; &apos;'Routine'&apos;-Schaedel-CT in der psychiatrischen Diagnostik

    Energy Technology Data Exchange (ETDEWEB)

    Pickuth, D.; Heywang-Koebrunner, S.H.; Spielmann, R.P. [Martin-Luther-Universitaet Halle-Wittenberg, Halle (Germany). Klinik und Poliklinik fuer Diagnostische Radiologie

    1999-11-01

    Purpose: To prospectively assess the spectrum of brain CT findings in psychiatric patients and to determine the number of patients that had an underlying cause for the symptoms. Patients and methods: Over a period of six months, 142 patients (78 males, 64 females; median age 61 [18-91] years) were referred for CT brain scans. Their scans were reviewed, along with the clinical information that was provided in the request form. All the hard copies were reviewed to assess areas of ischaemia, infarction, atrophy, tumours, and haematomas. The majority of requests were to exclude vascular event or space-occupying lesions. Clinical indications included mood disorders (depression, mania), schizophrenic disorders, dementia, personality and behavioural disorders. Results: 31 (22%) were normal. 111 (78%) had varying degrees of ischaemia, infarction and cerebral/cerebellar atrophy. 7 (4.9%) had space-occupying lesions which included two gliomas and five meningiomas. There were two chronic subdural haematomas and one arteriovenous malformation. Conclusion: 1. In our series, pathologic findings in &apos;routine&apos; brain CT&apos;s were encountered in 78%. 2. The incidence of brain tumours was 4.9%, compared with 0.00005% of the general population. 3. CT scanning in psychiatric patients is cost-effective and especially indicated when there is an atypical presentation, or inadequate response to standard treatment. (orig.) [German] Hintergrund: Bei psychiatrischen Patienten wird vielerorts routinemaessig eine kraniale Computertomographie (CCT) durchgefuehrt. Ob der Nutzen die Kosten rechtfertigt, wurde im Rahmen einer Prospektivstudie untersucht. Patienten und Methode: In einem Zeitraum von 6 Monaten wurde bei 142 psychiatrischen Patienten (78 Maenner, 64 Frauen, 18-91 Jahre, Median 61 Jahre) ein CCT angefertigt. Die Untersuchung erfolgt nativ in 5-mm-Schichtdicke, bei klinischem Verdacht auf eine intrakraniale Raumforderung auch kontrastverstaerkt. Ueberweisungsdiagnosen waren v

  19. Report of working committee 4 &apos;&apos;transmission of gases&apos;&apos;; Rapport de la commission 4 &apos;&apos;transport des gaz&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Volskij, E.

    2000-07-01

    Report of the WOC 4 Transmission contains the results of works carried out during 1998-2000 by the Committee members and the three study groups. The most important is: - review of actual situation and prospects for the gas pipeline transmission system development; - report of SG-4.1 &apos;Pipeline Ageing and Rehabilitation&apos;, including analysis of pipeline steels, welding and insulation, methods of rehabilitation, the program of pipeline reconstruction; - report of SG-4.2 &apos;Emission monitoring&apos; including appraisal of gas losses and methods of lowering of methane and other emissions of the gas units in different countries; - report of SG-4.3 &apos;Pipelines Integrity Management and Safety&apos; including basic information on gas pipeline failure intensity, key elements of the Integrity Management System of the gas transmission, methods of risk evaluation and the effectiveness of the approach. (authors)

  20. Antiproliferative and Proapoptotic Effects of Labisia pumila Ethanol Extract and Its Active Fraction in Human Melanoma HM3KO Cells.

    Science.gov (United States)

    Lope Pihie, Azimahtol Hawariah; Zakaria, Zainul Amiruddin; Othman, Fezah

    2012-01-01

    The present study was to determine the anticancer potential of Labisia pumila in in vitro models. Results from the study revealed that ethanol extract of L. pumila was more cytotoxic against HM3KO cells while having reduced effects on nonmalignant cells as compared to aqueous and hexane extracts. Thus, ethanol extract was selected to be further separated by using the bioassay-guided fractionation method to give an active fraction, SF2Lp. Results obtained from the flow cytometry analysis showed that SF2Lp was able to arrest the HM3KO cell cycle at the G1 phase, while morphological findings from AO-EB nuclear staining assays along with the Apoptotic Index confirmed the induction of apoptosis by SF2Lp in HM3KO cells. Results from the mechanistic study further revealed that SF2Lp treatment was able to concurrently increase the expression level of p53 and pro-apoptotic protein Bax and also reduce the expression level of anti-apoptotic protein BCl-2 in HM3KO cells, directly contributing to the increase in Bax/Bcl-2 ratio. These findings, therefore, suggested that L. pumila was able to inhibit HM3KO cell growth possibly by arresting the cell cycle at G1 phase and inducing apoptosis in HM3KO cells via the up- and down-regulation of Bax/Bcl-2 protein, mediated through a p53-dependent pathway. PMID:22474490

  1. Antiproliferative and Proapoptotic Effects of Labisia pumila Ethanol Extract and Its Active Fraction in Human Melanoma HM3KO Cells

    Directory of Open Access Journals (Sweden)

    Azimahtol Hawariah Lope Pihie

    2012-01-01

    Full Text Available The present study was to determine the anticancer potential of Labisia pumila in in vitro models. Results from the study revealed that ethanol extract of L. pumila was more cytotoxic against HM3KO cells while having reduced effects on nonmalignant cells as compared to aqueous and hexane extracts. Thus, ethanol extract was selected to be further separated by using the bioassay-guided fractionation method to give an active fraction, SF2Lp. Results obtained from the flow cytometry analysis showed that SF2Lp was able to arrest the HM3KO cell cycle at the G1 phase, while morphological findings from AO-EB nuclear staining assays along with the Apoptotic Index confirmed the induction of apoptosis by SF2Lp in HM3KO cells. Results from the mechanistic study further revealed that SF2Lp treatment was able to concurrently increase the expression level of p53 and pro-apoptotic protein Bax and also reduce the expression level of anti-apoptotic protein BCl-2 in HM3KO cells, directly contributing to the increase in Bax/Bcl-2 ratio. These findings, therefore, suggested that L. pumila was able to inhibit HM3KO cell growth possibly by arresting the cell cycle at G1 phase and inducing apoptosis in HM3KO cells via the up- and down-regulation of Bax/Bcl-2 protein, mediated through a p53-dependent pathway.

  2. Radiological assessment of skull base changes in children with syndromic craniosynostosis: role of &apos;'minor'&apos; sutures

    Energy Technology Data Exchange (ETDEWEB)

    Calandrelli, Rosalinda; D' Apolito, Gabriella; Gaudino, Simona; Stefanetti, Mariangela; Colosimo, Cesare [Universita Cattolica Sacro Cuore, Institute of Radiology, Rome (Italy); Massimi, Luca; Di Rocco, Concezio [Universita Cattolica Sacro Cuore, Institute of Neurosurgery, Rome (Italy)

    2014-10-15

    This study aims to identify the premature synostosis of &apos;'major'&apos; and &apos;'minor'&apos; sutures of the four &apos;&apos;sutural arches&apos;&apos; of the skull and to perform a morphometric analysis in children with syndromic craniosynostosis in order to evaluate changes in the skull base linked with premature suture synostosis. We reviewed multiplanar high-resolution CT images, implemented with 3D reconstructions, from 18 patients with complex syndromic craniosynostosis and compared them with 18 age-matched healthy subjects. We assessed the calvarial sutures and their extension to the skull base, and then we correlated specific types of synostosis with the size, shape and symmetry of the cranial fossae. We found a marked asymmetry of the skull base growth in all patients. The synostotic involvement around the coronal ring caused a reduction in the growth of the anterior and middle fossae. The size of the posterior cranial fossa was related not only to &apos;'major'&apos; but also to &apos;'minor'&apos; suture synostosis of the lambdoid and parieto-squamosal arches. Changes in the skull base and craniofacial axis symmetry are due to structural and functional relationships between &apos;'major'&apos; and &apos;'minor'&apos; skull sutures, suggesting a structural and functional relationship between the neurocranium and basicranium. The early recognition of prematurely closed skull base sutures may help clinicians and neurosurgeons to establish correct therapeutic approaches. (orig.)

  3. &apos;&apos;Substantial Margin of Safety&apos;&apos;: A New Approach to HLW Disposition

    Energy Technology Data Exchange (ETDEWEB)

    Power, M. S.

    2002-02-28

    In the Spring of 2001, the National Research Council published &apos;&apos;Disposition of High-Level Waste and Spent Nuclear Fuel: The Continuing Societal and Technical Challenges.&apos;&apos; (1) While finding the technical case for deep geologic disposal of high-level waste and spent fuel robust, the report focused new attention on societal issues and decision-making. The report appeared against a backdrop of heightened controversy about the development of a geologic repository at Yucca Mountain, Nevada. This paper identifies three principal reasons for the National Research Council committee&apos;s finding that &apos;&apos;Difficulties in achieving public support have been seriously underestimated in the past, and opportunities to gain public trust have been missed.&apos;&apos;

  4. A Mistaken Account of the Age-Crime Curve: Response to Males and Brown (2013)

    Science.gov (United States)

    Shulman, Elizabeth P.; Steinberg, Laurence; Piquero, Alex R.

    2014-01-01

    The present article responds to Males and Brown&apos;s "Teenagers&apos; High Arrest Rates: Features of Young Age or Youth Poverty?" which claims that the widely observed pattern of crime rates peaking in late adolescence or early adulthood is an artifact of age differences in poverty. We note that the authors&apos; interpretation of…

  5. Dietary cladode powder from wild type and domesticated Opuntia species reduces atherogenesis in apoE knock-out mice.

    Science.gov (United States)

    Garoby-Salom, Sandra; Guéraud, Françoise; Camaré, Caroline; de la Rosa, Ana-Paulina Barba; Rossignol, Michel; Santos Díaz, María del Socorro; Salvayre, Robert; Negre-Salvayre, Anne

    2016-03-01

    Dietary intake of Opuntia species may prevent the development of cardiovascular diseases. The present study was designed to characterize the biological antioxidant and anti-inflammatory properties of Opuntia species and to investigate whether Opuntia cladodes prevent the development of atherosclerosis in vivo, in apoE(-)KO mice. The effects of the two Opuntia species, the wild Opuntia streptacantha and the domesticated Opuntia ficus-indica, were tested on the generation of intra- and extracellular reactive oxygen species (ROS) production and kinetics of the LDL oxidation by murine CRL2181 endothelial cells and on the subsequent inflammatory signaling leading to the adhesion of monocytes on the activated endothelium and the formation of foam cells. Opuntia species blocked the extracellular ROS (superoxide anion) generation and LDL oxidation by CRL2181, as well as the intracellular ROS rise and signaling evoked by the oxidized LDL, including the nuclear translocation of the transcription factor NFκB, the expression of ICAM-1 and VCAM-1 adhesion molecules, and the adhesion of monocytes to CRL2181. In vivo, Opuntia significantly reduced the formation of atherosclerotic lesions and the accumulation of 4-hydroxynonenal adducts in the vascular wall of apoE-KO mice, indicating that Opuntia cladodes prevent lipid oxidation in the vascular wall. In conclusion, wild and domesticated Opuntia species exhibit antioxidant, anti-inflammatory, and antiatherogenic properties which emphasize their nutritional benefit for preventing cardiovascular diseases. PMID:26704378

  6. &apos;et&apos; special: &apos;&apos;E-world of energy&apos;&apos;; &apos;et&apos;-special: &apos;&apos;E-world of energy&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2001-02-01

    The &apos;et&apos; special on the conference &apos;E-world of energy&apos;, held from February 13 - 15, 2001 in Essen (Germany) presents contributions of experts who offer solutions to issues and many topical questions arising in the business of traders and utilities as participants of (international) energy markets at various stages of transition towards workable competition. The translated titles of the 15 contributions reproduced in this &apos;et&apos; special indicate the major contents of the conference papers: 1. Internet-based wholesale power trading as a competitive option to the power exchange. 2. Forward graphs in European electricity markets. 3. Portfolio management in energy trading. 4. Risk management concepts in energy trading. 5. E-commerce as a driving force of a change in the energy markets. 6. eHuman resources management - a vital aspect of corporate success. 7. A brand policy for electricity? 8. Is it really only the price that counts for the customers? 9. The City Power network: an example of successful customer loyalty strategy for local and regional utilities. 10. The Call Center, an important instrument for customer loyalty programmes. 11. eCommerce or eLlusion? 12. eBusiness as a corporate strategy. 13. Meeting the challenges of increasing IT requirements. 14. IT solutions for transmission and distribution network management. 15. Target costing - pinpointed cost planning and control for the energy supply industry. (orig./CB) [German] In dem &apos;et&apos;-Special zur Konferenz &apos;E-world of energy&apos;, die vom 13.- 15. Februar 2001 in Essen stattfand, bieten Experten Loesungsvorschlaege fuer die aktuellen Fragen und Probleme an, die sich auf dem Weg zu liberalisierten Energiemaerkten stellen. Die folgenden Titel der 15 Beitraege geben eine Uebersicht ueber den Inhalt der Konferenzbeitraege. Themen: 1. Internetbasierte Grosshandelsmaerkte als Konkurrenz zu Energieboersen 2. Forward-Kurven in europaeischen Strommaerkten 3

  7. Male Osteoporosis

    Directory of Open Access Journals (Sweden)

    Meltem Esenyel

    2004-03-01

    Full Text Available Osteoporosis in men is now recognized as an increasingly important public health issue. About 30 % of hip fractures and 20 % of vertebral fractures occur in men. In the present study, we examined 19 men who did not have major risk factors that might affect bone mass. Parathormone(PTH, osteocalcin (marker of bone formation, OC and deoxypyridinoline (marker of bone resorption, DPD were measured. The bone mineral density (BMD measurements in 16 men were performed by dual-energy X-ray absorbtiometry (DXA from lumbar spine (L2-4, and left hip. Bone density at each site was categorized as osteoporosis or osteopenia according to World Health Organization (WHO criteria. In 19 patients with a mean age of 69 years, PTH levels were in the normal range except one patient. OC levels were elevated in %42.1 and DPD levels were elevated in 74 % of patients. L2-4 T score was osteoporotic (25% in 4 patients and osteopenic (25% in 4 patients. Femur Ward’s T score was osteoporotic (37.5% in 7 patients and osteopenic (37.5% in 7 patients. Osteoporosis is a significant problem in older men. Increased awareness for the risk factors of male osteoporosis is an important issue. Early diagnosis and treatment would help to reduce morbidity and mortality resulting from osteoporotic fractures.

  8. OTROŠKO LJUDSKO IZROČILO ŠALEŠKE DOLINE

    OpenAIRE

    Pačnik, Anita

    2010-01-01

    Diplomsko delo OTROŠKO LJUDSKO IZROČILO ŠALEŠKE DOLINE je teoretično delo. Izkušnje dela v vrtcu narekujejo potrebo po raziskovanju tega področja, vendar se postavlja vprašanje literature. V Šaleški dolini delujejo folklorna društva za odrasle. Otroci večinoma spoznajo ljudsko izročilo v vrtcih ali doma, vendar je literature iz tega področja premalo. Vzgojiteljice si pomagajo z razno literaturo v kateri so združene rajalne igre iz celotne Slovenije ali sveta, ne morejo pa približati otrokom l...

  9. RAZVOJ TEHNOLOŠKO EKONOMSKEGA SIMULACIJSKEGA MODELA ZA PREDELAVO MESA NA KMETIJI

    OpenAIRE

    Puhan, Barbara

    2010-01-01

    Dopolnilna dejavnost na kmetiji je dejavnost, ki se opravlja na kmetiji z namenom izboljšanja njenega ekonomskega stanja. Cilj diplomske naloge je oceniti ekonomsko upravičenost predelave mesa v mesne izdelke (v našem primeru v prekmursko šunko). Za ocenjevanje ekonomske upravičenosti dopolnilne dejavnosti na kmetiji, bo razvit tehnološko-ekonomski simulacijski model za predelavo mesa. Z uporabo ustreznega simulacijskega modela bo med drugim omogočena izdelava kalkulacij skupnih stroškov za p...

  10. KIRURŠKO LIJEČENJE HALLUX LIMITUS/RIGIDUS U MLADE ŠPORTAŠICE

    OpenAIRE

    Lucijanić, Ivica; Mirković, Maja Mirković; Cicvara-Pećina, Tatjana; Pećina, Marko

    2010-01-01

    Hallux limitus/ rigidus određuje ograničenje dorzalne fleksije metatarzofalangealnog zgloba palca usljed stvaranja osteofita uokolo dorzalnog ruba glave prve metatarzalne kosti. Navode se mnogi uzroci nastanka uključujući i traumu. Liječenje je konzervativno ili kirurško, a primjenjuje se više vrsta kirurškog liječenja. Autori prikazuju sportašicu s hallux limitusom (drugi stupanj bolesti) operiranu u njezinoj 19. godini života s postoperativnim praćenjem od 10 godina....

  11. The Idea of an Innovated Concept of the Košice Geothermal Project

    Directory of Open Access Journals (Sweden)

    Bujanská Alena

    2015-11-01

    Full Text Available Slovakia has very limited amounts of fossil resources. However, it has a relatively high potential of geothermal energy which use is far below its possibilities. The most abundant geothermal resource, not only in Slovakia but throughout the central Europe, is Košice basin. Since the publication of the first ideas about the ambitious goal to exploit the geothermal potential of this site, 20 years has passed and three geothermal wells has been made but without any progress. In the article the authors present the idea of a fundamental change in the approach to improve the energy and economic efficiency of the project.

  12. Prikaz znanja u internetu stvari: semantičko modeliranje i njegove primjene

    OpenAIRE

    Wang, Wei; Suparna; Cassar, Gilbert; Moessner, Klaus

    2014-01-01

    Semantičko modeliranje pruža potencijalnu osnovu za me.udjelovanje različitih sustava i aplikacija unutar interneta stvari (IoT). Međutim, postojeći radovi uglavnom su fokusirani na upravljanje IoT resursima, ali ne i pristupu i korištenju informacija koje generira “stvar”. Predstavljamo projektiranje sveobuhvatnog i laganog semantičkog opisnog modela za prikaz znanja u IoT domeni. Projektiranje slijedi široko-priznate najbolje običaje u inženjerstvu znanja i ontološkom modeliranju. Korisnici...

  13. Anpassung des Kontrollverfahrens nach der EG-Öko-Verordnung an die Anforderungen der Kontrollverordnung

    OpenAIRE

    Neuendorff, Jochen

    2009-01-01

    Seit dem 1. Januar 2009 gelten die neuen EG-Rechtsregelungen zum Ökologischen Landbau. Diese lösten die seit 1991 geltende EG-Öko-Verordnung ab. In den Neuregelungen ist niedergelegt, dass das Kontrollsystem für Erzeugnisse des Ökologischen Landbaus im Einklang mit den Bestimmungen der Verordnung Nr. 882/2004 umgesetzt werden soll. Diese Regelung beeinflusst die Effektivität und die Effizienz des Kontrollsystems. Im Rahmen des Vorhabens wurde das Rechtsverhältnis zwischen den EG-Rechtsvors...

  14. Drittlandsimporte von Öko-Lebensmitteln in die Europäische Union

    OpenAIRE

    Neuendorff, Jochen; Steinhauser, Christoph

    2006-01-01

    Bio-Produkte liegen im Trend: der Markt für Produkte des Ökologischen Landbaus wächst mit zweistelligen Zuwachsraten. Mehr und mehr in Deutschland vermarktete Öko-Erzeugnisse stammen aus benachbarten EU-Ländern und aus Staaten außerhalb der Europäischen Union, den sogenannten „Drittländern“. Bei den Drittlandsimporten geht es längst nicht mehr nur um die „traditionellen“ landwirtschaftlichen Importprodukte wie zum Beispiel Kaffee oder Tee, die in Europa nicht erzeugt werden können. Heute stam...

  15. POVEZANOST MED STILOM VODENJA IN ZADOVOLJSTVOM ZAPOSLENIH V PODJETJU KOSTAK KRŠKO D.D.

    OpenAIRE

    Novoselc, Tamara

    2014-01-01

    Zelo pomembno je, da ima podjetje uspešne vodje, da imajo svoj stil vodenja, ki jim pomaga izpolniti delovne naloge in s tem doseči uspeh. Vodja mora dodeljevati naloge zaposlenim, jim pomagati pri nastalih težavah in jim omogočiti zadovoljstvo na delovnem mestu. Povezanost v timih pa je ključnega pomena. Cilj diplomske naloge je spoznati različne stile vodenja, pojem vodenje, kakšno vodenje prevladuje in kako so zaposleni zadovoljni s stilom vodenja v družbi Kostak Krško, d. d. Samo zado...

  16. Avtomatsko luščenje hrvaško-slovenskega leksikona iz primerljivih korpusov

    OpenAIRE

    Ljubešić, Nikola; Fišer, Darja

    2015-01-01

    V prispevku predstavljamo metodo za avtomatsko luščenje hrvaško-slovenskega leksikona iz primerljivega časopisnega korpusa s predpostavko, da se besede in njihove prevodne ustreznice pojavljajo v podobnih sobesedilih. Izhodiščni leksikon za primerjavo kontekstnih vektorjev z izkoriščanjem podobnosti med jezikoma zgradimo kar iz korpusa, nato pa opravimo še razvrščanje rezultatov glede na stopnjo sorodnosti med izvorno besedo in njenimi prevodnimi kandidati. Rezultati so zelo spodbudni in odpi...

  17. UPORABA OGRODJA OPENLASZLO ZA IZGRADNJO UPORABNIŠKO BOGATIH SPLETNIH APLIKACIJ

    OpenAIRE

    Rebernak, Jasmina

    2011-01-01

    Danes je za izgradnjo uporabniško bogatih spletnih aplikacij na voljo veliko različnih ogrodij. Eno takšnih je odprtokodno ogrodje OpenLaszlo, katerega razvoj se je pričel pred dobrim desetletjem. Preprostost pri razvoju aplikacij, neodvisnost od urejevalnika za pisanje kode in prenosljivost med spletnimi brskalniki so le nekatere izmed prednosti, ki jih ponuja to ogrodje. Eden izmed sestavnih delov tega ogrodja je programski jezik LZX, katerega prednost je podobnost s HTML-jem in JavaScript-...

  18. SURADNIČKO UČENJE U SVEUČILIŠNOJ NASTAVI

    OpenAIRE

    Bognar, Ladislav

    2006-01-01

    Pojam suradničko učenje (cooperative learning) javio se najprije kod američkih autora kao odgovor na natjecateljsko učenje (competitive learning). Na to su utjecala istraživanja Lewina o kooperativnim i kompetitivnim odnosima u grupnoj dinamici. U evropskoj didaktici već je od ranije bio afirmiran grupni oblik (pored frontalnog i individualnog) pa se taj termin prihvaća kao sinonim za grupni oblik dajući naglasak na kvalitetu odnosa koje taj oblik treba njegovati. U sveučilišnoj n...

  19. Uporaba računalniško podprte procesne tehnike za integracijo industrijskih procesov

    OpenAIRE

    Tokoš, Hela

    2009-01-01

    Procesna integracija je učinkovito orodje, ki omogoča podjetjem, da obstoječo proizvodnjo prilagodijo načelom trajnostnega razvoja, saj lahko z integracijo znižajo porabo sveže vode, toplote, električne energije in drugih virov ter zmanjšajo okoljske obremenitve. Orodja računalniško podprte procesne tehnike, ki temeljijo na matematičnem programiranju, omogočajo sistematično in simultano obravnavanje procesnih problemov. Uporaba v realnih industrijskih primerih pogosto zahteva različne modifik...

  20. The Idea of an Innovated Concept of the Košice Geothermal Project

    OpenAIRE

    Bujanská Alena; Böszörményi László

    2015-01-01

    Slovakia has very limited amounts of fossil resources. However, it has a relatively high potential of geothermal energy which use is far below its possibilities. The most abundant geothermal resource, not only in Slovakia but throughout the central Europe, is Košice basin. Since the publication of the first ideas about the ambitious goal to exploit the geothermal potential of this site, 20 years has passed and three geothermal wells has been made but without any progress. In the article the a...

  1. The Idea of an Innovated Concept of the Košice Geothermal Project

    Science.gov (United States)

    Bujanská, Alena; Böszörményi, László

    2015-11-01

    Slovakia has very limited amounts of fossil resources. However, it has a relatively high potential of geothermal energy which use is far below its possibilities. The most abundant geothermal resource, not only in Slovakia but throughout the central Europe, is Košice basin. Since the publication of the first ideas about the ambitious goal to exploit the geothermal potential of this site, 20 years has passed and three geothermal wells has been made but without any progress. In the article the authors present the idea of a fundamental change in the approach to improve the energy and economic efficiency of the project.

  2. Terorizam i biološko i toksinsko oružje

    OpenAIRE

    Bokan, Slavko

    2003-01-01

    Biološko i toksinsko oružje se koristi u biološkom ratu s ciljem namjernog izazivanja masovnih infektivnih bolesti ljudi, životinja i korisnog bilja u epidemijskim razmjerima te slabljenja ratnih potencijala protivnika. Biološki i toksinski ratni agensi ukljuèuju sve patogene mikroorganizme kao što su virusi, rikecije, bakterije, gljivice i protozoe, prirodne, izmijenjene ili sintetizirane (genetičkim inženjerstvom ili drugim biotehnološkim postupcima) i njihove toksine ako su namijenjeni za ...

  3. Osveščenost mladostnikov o dejavnikih tveganja za kožni melanom

    OpenAIRE

    Škofič, Ines

    2014-01-01

    V diplomskem delu smo predstavili melanom, dejavnike tveganja za nastanek kožnega melanoma, njegovo zdravljenje in preventivo v obliki osveščanja prebivalstva in pravilni zaščiti pred UV sevanjem. Melanom je nevaren v vseh življenjskih obdobjih, ampak če ga odkrijemo dovolj zgodaj je popolnoma ozdravljiv tako, da je velik poudarek na preventivi kot je redno samopregledovanje in pravilni ultravijolični (UV) zaščiti. Raziskava je potekala na dveh različnih srednjih šolah, Srednji zdravstveni...

  4. Neobično krojačko umijeće Thomasa Pynchona

    OpenAIRE

    Novaković, Jurica

    2014-01-01

    Iako bi primitivni čovjek najvjerojatnije ustuknuo pred likovima odjevenima „à la Pynchon“ poput Ruperte u uskom crnom kostimu od bengalske svile s medičejskim ovratnikom i posuvracima od lažnog krzna činčile ili jazz glazbenika Chestera LeStreeta u sjajnom sivom kamgarn odijelu, košulji i ukrasnim rupčićem u istoj jarkoj nijansi fuksije, homburg šeširu boje sladoleda, ručno obojenoj kravati i tamnim sunčanim naočalama s okvirima od kornjačevine, suvremeni čitatelji opremljeni kulturnim dosti...

  5. Safety of the &apos;'man-machine-environment'&apos; system during well drilling

    Energy Technology Data Exchange (ETDEWEB)

    Fedorenko, V.I.; Fedorov, V.A.; Loginovskiy, V.I.; Nugayev, R.Ya.

    1982-01-01

    A review is given of safety of the oil and gas well drilling process, which depends on the correspondence and organization of the interaction of all components of the &apos;'man-machine-environment'&apos; system. The reasons for accidents, dangerous situations and emergencies are analyzed. An examination is made of the ergonomic characteristics of the system, questions of the study and development of ergonomic requirements for work site design at a drilling rig, and possible ways of improving these indices. Certain equipment is described that ensures safety of the &apos;'man-machine-environment'&apos; system during well drilling, improves the microclimatic working conditions, and eliminates shortcomings in equipment design.

  6. Development of an object oriented lattice QCD code &apos;'Bridge++'&apos;

    International Nuclear Information System (INIS)

    We are developing a new lattice QCD code set &apos;'Bridge++'&apos; aiming at extensible, readable, and portable workbench for QCD simulations, while keeping a high performance at the same time. Bridge++ covers conventional lattice actions and numerical algorithms. The code set is constructed in C++ with an object oriented programming. In this paper we describe fundamental ingredients of the code and the current status of development

  7. Moessbauer spectroscopic and electrochemical studies on 1&apos;, 1&apos;'&apos;-dihalobiferrocenes

    Energy Technology Data Exchange (ETDEWEB)

    Motoyama, Izumi; Suto, Kyoko; Katada, Motomi; Sano, Hirotoshi (Tokyo Metropolitan Univ. (Japan). Faculty of Science)

    1983-08-01

    In the Mossbauer spectroscopic studies on the triiodide salts of a series of 1&apos;,1&apos;'&apos;-dihalobiferrocenes, it has been found that the monocations of diiodo- and dibromobiferrocene show averaged valence states of iron atoms, while the monocation salt of dichlorobiferrocene shows a trapped valence state of iron atoms. On the other hand, no difference has been found in the half-wave potentials of the halobiferrocenes.

  8. Role of glaciers in watershed hydrology: &apos;&apos;Himalayan catchment&apos;&apos; perspective

    OpenAIRE

    R. J. Thayyen; J. T. Gergan

    2009-01-01

    A large number of Himalayan glacier catchments are under the influence of humid climate with snowfall in winter (November–April) and South-West monsoon in summer (June–September) dominating the regional hydrology. Such catchments are defined as &apos;&apos;Himalayan catchment&apos;&apos;, where the glacier melt water contributes to the river flow during the period of annual high flows produced by the monsoon. Other two major glacio-hydrological regimes of the Himalaya are winter snow do...

  9. Radiologically visible fecal gas patterns in &apos;'normal'&apos; newborns and young infants

    Energy Technology Data Exchange (ETDEWEB)

    Patriquin, H.B.; Fisch, C.; Bureau, M.; Black, R.

    1984-02-01

    A prospective study of abdominal and chest films of 212 babies without symptoms of intra-abdominal disease, aged 1 day-12 weeks, showed that the bubbly &apos;&apos;fecal pattern&apos;&apos; normally seen in older children is rare in young premature babies in the first two weeks of life. When it is seen, it may represent intramural air bubbles and signal the presence of necrotizing enterocolitis.

  10. Male Reproductive System

    Science.gov (United States)

    ... I Help a Friend Who Cuts? Male Reproductive System KidsHealth > For Teens > Male Reproductive System Print A ... reproductive systems. continue What Is the Male Reproductive System? Most species have two sexes: male and female. ...

  11. Cloning and Expression of Apolipoprotein E3 and Its Variant apoE2 and apoE4

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    In order to obtain three isoforms of apolipoprotein E (apoE), the cDNA encoding apoE3 was obtained by RT-PCR from normal human liver tissue. Site-directed mutagenesis was used to obtain the cDNAs encoding apoE2 and apoE4 isoforms. The 3 cDNAs were subcloned into vector pGEM-3Z and verified by DNA sequencing. The expression recombinant which can express the target protein as a (His) 6-tagged fusion was constructed by subcloning apoE cDNA into vector pT7-PL. The purified proteins were gained by Ni-NTA column. The SDS-PAGE results revealed the 6 His fusion proteins (apoE2, apoE3 and apoE4) were correctly expressed and purified successfully.

  12. Control of releases of radioactive aerosols from object &apos;'Ukryttya'&apos; in 2014

    International Nuclear Information System (INIS)

    The results of control of radioactive particulate emission are presented from the object &apos;'Ukryttya'&apos; in 2014. The maximal rate of unorganized releases of beta-radiating products of Chernobyl accident was in winter period and reached 3.6 MBq/day. The concentration of long-lived beta-radiating aerosols released in atmosphere from system &apos;'Bypass'&apos; was within the range 0.3 - 5 Bq/m3 (maximal concentration was 14 Bq/m3). Them carriers were particles with active median aerodynamic diameter (AMAD) 0.6 - 6 μm. Mean ratio of concentrations were: 137Cs/241Am = 97 i 241Am/154Eu = 6.2. The concentration of 212Pb - daughter products of thoron consisted as a rule 0.8 - 4 Bq/m3. Maximal concentration of 212Pb aerosols was 9 Bq/m3. The relation of concentrations of daughter products of radon and thoron and 212Pb were about 4. They have AMAD 0.06 - 0.3 μm. A volume activity and dispersity of radioactive aerosols in releases from object &apos;'Ukryttya'&apos; remain constant the last ten years

  13. 2001 &apos;&apos;You Have the Power&apos;&apos; campaign [Federal Energy Management Program]. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-01-01

    The Tasks of 2001 &apos;&apos;You Have the Power&apos;&apos; campaign by the Federal Energy Management Program (FEMP) are: Task 1--Interagency Planning Meetings; Task 2--Ear Day Event; Task 3--Earth Day and Energy Awareness Month Activities; Task 4--Regional Target; Task 5--Outreach Tools and Campaign Products; Task 6--Private Sector Participation; Task 7--&apos;&apos;You Have the Power&apos;&apos; on the FEMP Web Site; and Task 8--Effective Communications.

  14. Current Structural Design of Side Wall in KO HCCR TBM for ITER

    Energy Technology Data Exchange (ETDEWEB)

    Shin, K. I.; Lee, D. W.; Gon, J. H.; Lee, E. H.; Kim, S. K.; Yoon, J. S. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Cho, S. [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    To accomplish the test and validation of the tritium self-sufficiency and a heat transfer extraction during ITER operation, the KO HCCR TBM (Korean Helium Cooled Ceramic Reflector Test Blanket Module) has been developed considering the unique concept of using a graphite reflector. The TBM consists of four sub-modules and one Back Manifold (BM), and each sub-module is composed of a First Wall (FW), Breeding Zone (BZ), Side Wall (SW), and BZ (Breeding Zone) box, which contains beryllium (Be), lithium (Li), and graphite pebbles. Among them, SW has functions as a manifold for the cooling flow distribution from FW cooling channels to BZ, and it should sustain the internal coolant pressure. In this study, the structural design of the SW was performed according to the RCC-MR design code to confirm the design requirement for ITER. To satisfy the KO HCCR TBM design requirements, structural analyses were performed for the preliminary SW design in the TBM. A design channel pressure of 10MPa was considered in the structural design progress of the SW. The stress breakdown was evaluated through PATH in SW. It was concluded that the results satisfy the design requirements in the RCC-MR codes for the ITER.

  15. Fmr1 KO Mice as a Possible Model of Autistic Features

    Directory of Open Access Journals (Sweden)

    Maude Bernardet

    2006-01-01

    Full Text Available Autism is a pervasive developmental disorder appearing before the age of 3, where communication and social interactions are impaired. It also entails stereotypic behavior or restricted interests. Although this disorder was first described in 1943, little is still known about its etiology and that of related developmental disorders. Work with human patients has provided many data on neuropathological and cognitive symptoms, but our understanding of the functional defects at the cellular level and how they come about remains sketchy. To improve this situation, autism research is in need of valid animal models. However, despite a strong hereditary component, attempts to identify genes have generally failed, suggesting that many different genes are involved. As a high proportion of patients suffering from the Fragile X Syndrome show many autistic symptoms, a mouse model of this disorder could potentially also serve as a model for autism. The Fmr1 KO mouse is a valid model of the Fragile X Syndrome and many data on behavioral and sensory-motor characteristics of this model have been gathered. We present here an assessment of autistic features in this candidate model. We conclude that Fmr1 KO mice display several autistic-like features, but more work is needed to validate this model.

  16. Behavioral analysis of male and female Fmr1 knockout mice on C57BL/6 background

    OpenAIRE

    Ding, Qi; Sethna, Ferzin; Wang, Hongbing

    2014-01-01

    Fragile X syndrome (FXS) is a monogenic disease caused by mutations in the FMR1 gene. The Fmr1 knockout (KO) mice show many aspects of FXS-related phenotypes, and have been used as a major pre-clinical model for FXS. Although FXS occurs in both male and female patients, most studies on the mouse model use male animals. Few studies test whether gender affects the face validity of the mouse model. Here, we examined multiple behavioral phenotypes with male hemizygous and female homozygous Fmr1 K...

  17. The German &apos;'Energiewende'&apos;. Evaluation after the Paris-agreement; Die Deutsche Energiewende. Bewertung nach dem Klima-Abkommen von Paris

    Energy Technology Data Exchange (ETDEWEB)

    Roth, Eike

    2016-08-01

    The World-Climate-Summit 2016 in Paris agreed to exacerbated goals for climate protection. This paper will scrutinize whether Germany can comply with its Paris-obligations by continuing the ongoing German &apos;'Energiewende'&apos;. The result is clear-cut: The German &apos;'Energiewende'&apos; is inadequate. Due to the cap-and-trade system of the EU the &apos;''Energiewende'&apos;.

  18. [KoMPASS--design, implementation and experiences concerning a structured communication skills training for physicians dealing with oncology].

    Science.gov (United States)

    Vitinius, Frank; Sonntag, Bernd; Barthel, Yvette; Brennfleck, Barbara; Kuhnt, Susanne; Werner, Andreas; Schönefuß, Götz; Petermann-Meyer, Andrea; Gutberlet, Susanne; Stein, Barbara; Söllner, Wolfgang; Kruse, Johannes; Keller, Monika

    2013-12-01

    Goal of the KoMPASS project is to develop and test a training program that effectively improves oncologists' communication skills. The training draws with regard to concept, content and didactic methods to the specific challenges arising in interactions with cancer patients. Concept and didactical methods for an intensive training (KoMPASS Training) are being presented and complemented with experiences gathered during 39 trainings with 335 physicians, as well as findings from the training evaluation by participants. The participants' feedback after 4 months indicates successful transfer into clinical practice along with personal relief, improved self-efficacy, and communicative competencies. Even experienced practitioners ascribe high practical usefulness, and personal learning achievements to the KoMPASS training. The results of the concomitant study concerning self-efficacy, empathy, work-related stress and communicative competence will be published later. PMID:23677627

  19. Reakcija koštanoga tkiva u ovaca nakon ugradnje umjetnoga bočnoga zgloba upotrebom fiksacijskog cementa

    OpenAIRE

    Franka, Daroslav; Ledecký, Valent; Bodnár, Jozef; Hluchý, Marián; Horňák, Slavomír; Ushmirsky, Michael; Ledecká, Katarína; Skurková, Lenka

    2010-01-01

    Ovce su bile upotrijebljene kao model za istraživanje rendgenskih i histoloških promjena u koštanom tkivu nakon ugradnje umjetnoga bočnoga zgloba. Rendgenski su bile pregledane mjesec dana, te tri i šest mjeseci nakon što im je jednostrano bio ugrađen umjetni bočni zglob. Šest mjeseci nakon operacije ovce su bile eutanazirane, a koštano je tkivo bilo uzeto za histološku pretragu. Histološka pretraga bila je usmjerena na površinske promjene, promjene koštanoga tkiva te tip i broj prisutnih sta...

  20. Analysis Of α And f Parameters And ko Factor In Irradiation Sites of RSG G.A. Siwabessy Reactor

    International Nuclear Information System (INIS)

    Determination of neutron flux thermal to epithermal ratio f and parameter a and ko factor has been done in irradiation facility of RSG G.A. Siwabessy reactor. Those parameters are needed to determine the concentration of an element in a sample using ko NAA method. While parameters f were measured using foil activation method. α parameter was obtained from power function fitting at epithermal neutron spectrum. Based on the fitting method, the α parameter (non 1/E epithermal spectrum) was determined of 0.0267, 0.0255 and -0.0346 at system rabbit, IP2 and CIP irradiation position, respectively. The ko factor is dependent on absolute gamma fraction, thermal cross section and resonance integral. The neutron flux thermal to epithermal ratio f at all rabbit system is about 40, which is met for neutron activation analysis

  1. European day &apos;&apos;in town, without my car&apos;&apos;; Journee europeen &apos;&apos;en ville, sans ma voiture&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-10-01

    70 million inhabitants took part in the day &apos;&apos;In town, without my car&apos;&apos; on 22 September of this year. It is a great success for this European first. The objective of Energie-Cites association being to promote sustainable local energy policies, that is to say policies aimed at improving energy efficiency, increasing the use of renewable energy sources and limiting nuisance and pollution linked to energy consumption, the association is pleased that this event helped focus public attention on transport. It is indeed in this sector that uncontrolled upswings in energy consumption and greenhouse gas emissions are the most important. This report presents the evaluation of this European initiative and details the actions in some towns. (A.L.B.)

  2. Connections of the corticomedial amygdala in the golden hamster. I. Efferents of the &apos;&apos;vomeronasal amygdala&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Kevetter, G.A.; Winans, S.S.

    1981-03-20

    The medial (M) an posteromedial cortical (C3) amygdaloid nuclei and the nucleus of the accessory olfactory tract (NAOT) are designated the &apos;&apos;vomeronasal amygdala&apos;&apos; because they are the only components of the amygdala to receive a direct projection from the accessory olfactory bulb (AOB). The efferents of M and C3 were traced after injections of /sup 3/H-proline into the amygdala in male golden hamsters. Frozen sections of the brains were processed for autoradiography. The efferents of the &apos;&apos;vomeronasal amygdala&apos;&apos; are largely to areas which are primary and secondary terminal areas along the vomeronasal pathway, although the efferents from C3 and M terminate in different layers in these areas than do the projections from the vomeronasal nerve or the AOB. Specifically, C3 projects ipsilaterally to the internal granule cell layer of the AOB, the cellular layer of NAOT, and layer Ib of M. Additional fibers from C3 terminate in a retrocommissural component of the bed nucleus of the strain terminalis (BNST) bilaterally, and in the cellular layers of the contralateral C3. The medial nucleus projects to the cellular layer of the ipsilateral NAOT, layer Ib of C3, and bilaterally to the medial component of BNST. Projections from M to non-vomeronasal areas terminate in the medial preoptic area-anterior hypothalamic junction, ventromedial nucleus of the hypothalamus, ventral premammillary nucleus and possibly in the ventral subiculum. These results demonstrate reciprocal connections between primary and secondary vomeronasal areas between the secondary areas themselves. They suggest that M, but not C3, projects to areas outside this vomeronasal network. The medial amygdaloid nucleus is therefore an important link between the vomeronasal organ and areas of the brain not receiving direct vomeronasal input.

  3. ApoE polymorphisms in narcolepsy

    OpenAIRE

    Kasten Meike; Wieczorek Stefan; Dahmen Norbert; Gencik Martin; Gencikova Alexandra; Epplen Jorg T

    2001-01-01

    Summary Background Narcolepsy is a common neuropsychiatric disorder characterized by increased daytime sleepiness, cataplexy and hypnagogic hallucinations. Deficiency of the hypocretin neurotransmitter system was shown to be involved in the pathogenesis of narcolepsy in animals and men. There are several hints that neurodegeneration of hypocretin producing neurons in the hypothalamus is the pathological correlate of narcolepsy. The ApoE4 allele is a major contributing factor to early-onset ne...

  4. Habitat Characteristics of Bracken-Covered Areas Intended for Afforestation in Ličko Sredogorje

    Directory of Open Access Journals (Sweden)

    Zvonko Seletković

    2013-12-01

    Full Text Available Background and Purpose: Forest cultures in continental part of Croatia are mainly based on bracken-covered areas and moors on deserted agriculture soils and pastures. Successful afforestation i.e. establishment of forest cultures depends among other things on the understanding of habitats and ecology of forest trees. The choice of best species of forest trees for afforestation needs to be based on the research in soil and climate characteristics of target habitats. The aims of this research were to show mesoclimatic characteristics of Ličko sredogorje and microclimatic and pedological characteristics of Ličko polje. Also, based on habitat characteristics and ecology of forest trees, the aim was to determine species of forest trees suitable for afforestation of bracken-covered areas. Materials and Methods: Climate, microclimate, pedological and plant nutrition researches were done at the area of Lika highlands. Climate analysis was done according to air temperatures, amount of precipitation, relative air humidity and other climate elements and appearances. Composite soil samples were taken from the depth of 0-30 cm in order to determine plant nutrition potential. Samples were prepared for further analysis in the laboratory. Results: The highest average annual air temperature of 9.6 °C was found at weather station Gračac and the lowest at Korenica station (8.1 °C. Average amount of precipitation for this region was around 1500 mm. Monthly rain factors were ranging from arid to perhumid. Considering thermal character of the climate, the area has moderately warm climate. Average volumetric soil humidity is 14.2 %. Soil has strong acid reaction, is very humus, good to richly supplied with total nitrogen, content of physiologically active phosphorus and potassium is low, and C/N ration normal. Conclusions: According to habitat characteristics in the area of Ličko sredogorje and ecological demands of forest tree species, forest cultures of Common

  5. Uporaba laserske svetlobe kot predpriprava tekstilne odpadne vode za biološko čiščenje

    OpenAIRE

    Dornik, Črt

    2013-01-01

    Tekstilne odpadne vode so zelo kompleksne mešanice in so zelo težko biološko razgradljive. Poleg tega je zančilnost tekstilnih odpadnih vod še močna obarvanost in visoka kemijska potreba po kisiku. Navadne čistilne naprave so neuspešne pri razbarvanju in čiščenju tovrstnih odpadnih vod. V našem poskusu smo obdelovali močno obarvano tekstilno odpadno vodo iz Tekstine - Tekstilna Ajdovščina d.d. Za ta namen smo uporabljali dva laserja, ekscimerni XeCl (308 nm) in kontinuirni Ar - ionski laser (...

  6. Heavy metal contamination of paddy soils and rice (Oryza sativa L.) from Kočani Field (Macedonia)

    OpenAIRE

    Rogan, Nastja; Serafimovski, Todor; Dolenec, Matej; Tasev, Goran; Dolenec, Tadej

    2009-01-01

    This research focuses on the heavy metal contamination of the paddy soils and rice from Kočani Field (eastern Macedonia) resulting from irrigation by riverine water impacted by past and present base-metal mining activities and acid mine drainage. Very high concentrations of As, Cd, Cu, Pb and Zn were found in the paddy soils (47.6, 6.4, 99, 983 and 1,245 μg g-1) and the rice (0.53, 0.31, 5.8, 0.5 and 67 μg g-1) in the western part of Kočani Field, close to the Zleto...

  7. Ishodi učenja i inkluzivna edukacija učenika s intelektualnim teškoćama

    OpenAIRE

    Žiljak, Ognjen

    2014-01-01

    U članku se istražuju mogućnosti primjene ishoda učenja kao kriterija evaluacije inkluzivne edukacije učenika s intelektualnim teškoćama. Inkluzivna edukacije je specifičan pristup uključivanju osoba s intelektualnim teškoćama u redovno obrazovanja, te se temelji na ljudskim pravima. Ishodi učenja posljednjih godina postaju važan instrument obrazovne politike, naročito kao kriterij evaluacije obrazovanja. Analiza mogućnosti primjene ishoda učenja kao kriterija evaluacije inkluzivne edukacije ...

  8. Kirurško liječenje neuralgije kao posljedice idiopatskog okoštavanja mentalnog otvora

    OpenAIRE

    Ivasović, Zoran; Katanec, Davor; Pavelić, Božidar; Blažeković, Ana-Marija

    2004-01-01

    Prikazan je slučaj bolesnika s osteomom donje čeljusti koji je svojim rastom izazivao kompresiju mentalnoga živca i neuralgiformne boli. Intraoralnim pregledom nisu nađeni koštani deformiteti čeljusti, a dijagnoza je potvrđena rentgenskim nalazom, što govori da se radi o enostozi ili središnjem osteomu. U prikazu je opisana i operativna tehnika eksterne dekompresije kojom je epineuralna ovojnica živca oslobođena od pritiska nastalog rastom benigne koπtane tvorbe. Šest mjeseci nakon zahvata pa...

  9. Vrste peluda drveća i rizik od polenoza u Osječko-baranjskoj županiji

    OpenAIRE

    Sikora, Magdalena; Valek, Marina; Šušić, Zdenka; Santo, Vera; Brdarić, Dario

    2013-01-01

    Šume sjeveroistočnog dijela Hrvatske, kao i raznolike biljne vrste parkova i perivoja gradova Osječkobaranjske županije tijekom perioda polinacije stvaraju velike količine peluda koji kod osjetljivih osoba može izazvati simptome alergije – polenoze. Tijekom 2009. i 2010. godine radnici Službe za zdravstvenu ekologiju ZZJZ-a Osječko-baranjske županije provodili su monitoring koncentracija peluda u četiri grada u Osječko-baranjskoj županiji (Osijek, Našice, Đakovo, Beli Manastir). Mjerenja su s...

  10. Determination of heavy metals in paddy soils (Kočani Field, Macedonia) by a sequential extraction procedure

    OpenAIRE

    Rogan, Nastja; Dolenec, Tadej; Serafimovski, Todor; Tasev, Goran; Dolenec, Matej

    2008-01-01

    In this study we examine the distribution of heavy metals (As, Cd, Cu, Pb and Zn) in paddy soil samples from Kočani Field (Macedonia) by ICP-EAS and sequential extraction procedure. Very high concentrations of As (42 mg/kg), Cd (5.6 mg/kg), Cu (99 mg/kg), Pb (892 mg/kg) and Zn (1134 mg/kg) were found in the paddy soil sample from location VII-2 in the western part of Kočani Field, close to the Zletovska River, which drains the untreated effuents of the Pb-Zn mine in Zletovo and is used for th...

  11. Multielement Analysis of Libyan Soils by ko Instrumental Neutron Activation Analysis

    International Nuclear Information System (INIS)

    This paper concentrates on the assessment of theko-method of instrumental neutron activation in soil analysis without relying on the standard reference materials. This method has been applied in multielement analysis of soil samples. Using reactor neutron activation analysis based on ko method, numerous elements were determined in the samples in single irradiation. The samples were irradiated for 8 hours under thermal neutron flux ∼ 8.9x1012 n cm-2 s-1 in channel VCR11 of Tajura Research reactor. The accuracy of the method was ascertained by the analysis of the reference materials SL-1 and SoilL-7. The results are weighted mean with the expected/observed uncertainties (%) based on the standard deviation in the peak area. (Authors)

  12. Čimbenici kvalitete življenja osoba s intelektualnim teškoćama

    OpenAIRE

    Bratković, Daniela; Rožman, Bojana

    2006-01-01

    Polazeći od općeg definiranja pojma i čimbenika kvalitete življenja, u radu je dat pregled suvremenih spoznaja o čimbenicima i indikatorima procjene kvalitete življenja osoba s intelektualnim teškoćama. Navodeći tumačenja osnovnih dimenzija kvalitete življenja u kontekstu različitih teorijskih polazišta, naglašava se značaj multidimenzionalnog i interakcionalnog pristupa ovom području istraživanja. Kritički se razmatraju dosadašnje tendencije istraživanja o obilježjima kvalitete živl...

  13. Analysis of sediment samples by reactor neutron activation analysis using Ko method

    International Nuclear Information System (INIS)

    The study on the determination of elemental concentration in sediments from lakes and other water bodies is of prime importance for geological as well as environmental studies. The profile of different elements with prior knowledge of sedimentation rates might provide clues to knowledge of their possible origin. The results on the determination of elemental concentration in sediments from Nanital lake at different depths are presented using single comparator neutron activation analysis (KoNAA) method. Irradiations of samples along with gold as comparator were carried out in Apsara reactor at Bhabha Atomic Research Centre. The concentrations of Na, K, Mn, Cu, Ba, As, Sr, Sc, La, Sm, Eu and Dy were determined. Variations in concentration of different elements in the sediment samples as a function of depth and the derived correlations are presented in this paper. (author). 5 refs., 1 fig., 1 tab

  14. Raziskava samonadzora ekološko usmerjenih voznikov z mobilno aplikacijo

    OpenAIRE

    Batistič, Egon

    2015-01-01

    V sodobnem svetu se vse bolj poudarja ekološki slog življenja. Ta trend se kaže tudi v avtomobilski industriji, kjer skušajo razviti čim bolj varčne avtomobile in tudi takšne, ki za delovanje ne bodo potrebovali fosilnih goriv. Kratkoročne smernice avtomobilske industrije pa poudarjajo ekološko vožnjo, kar pomeni zmanjšano porabo goriva in posledično izpustov toplogrednih plinov. Pri takšni vožnji voznik vpliva na manjšo porabo goriva. V magistrskem delu so opisani različni sistemi nadzora vo...

  15. Calcium sensitivity and myofilament lattice structure in titin N2B KO mice

    Science.gov (United States)

    Lee, Eun-Jeong; Nedrud, Joshua; Schemmel, Peter; Gotthardt, Michael; Irving, Thomas C.; Granzier, Henk L

    2012-01-01

    The cellular basis of the Frank-Starling “Law of the Heart” is the length-dependence of activation, but the mechanisms by which the sarcomere detects length changes and converts this information to altered calcium sensitivity has remained elusive. Here the effect of titin-based passive tension on the length-dependence of activation (LDA) was studied by measuring the tension-pCa relation in skinned mouse LV muscle at two sarcomere lengths (SLs). N2B KO myocardium, where the N2B spring element in titin is deleted and passive tension is elevated, was compared to WT myocardium. Myofilament lattice structure was studied with low-angle X-ray diffraction; the myofilament lattice spacing (d10) was measured as well as the ratio of the intensities of the 1,1 and 1,0 diffraction peaks (I11/I10) as an estimate of the degree of association of myosin heads with the thin filaments. Experiments were carried out in skinned muscle in which the lattice spacing was reduced with Dextran-T500. Experiments with and without lattice compression were also carried out following PKA phosphorylation of the skinned muscle. Under all conditions that were tested, LDA was significantly larger in N2B KO myocardium compared to WT myocardium, with the largest differences following PKA phosphorylation. A positive correlation between passive tension and LDA was found that persisted when the myofilament lattice was compressed with Dextran and that was enhanced following PKA phosphorylation. Low-angle X-ray diffraction revealed a shift in mass from thin filaments to thick filaments as sarcomere length was increased. Furthermore, a positive correlation was obtained between myofilament lattice spacing and passive tension and the change in I11/I10 and passive tension and these provide possible explanations for how titin-based passive tension might regulate calcium sensitivity. PMID:23246787

  16. ECU tendon &apos;'dislocation'&apos; in asymptomatic volunteers

    Energy Technology Data Exchange (ETDEWEB)

    Petchprapa, Catherine N. [New York University Langone Medical Center, Hospital for Joint Diseases, Department of Radiology, New York, NY (United States); Meraj, Seema [Zwanger-Pesiri Radiology Group, Lindenhurst, NY (United States); Jain, Nidhi [New York University School of Medicine, New York University Langone Medical Center, Department of Radiology, New York, NY (United States)

    2016-06-15

    Assess extensor carpi ulnaris (ECU) tendon position in the ulnar groove, determine the frequency of tendon &apos;'dislocation'&apos; with the forearm prone, neutral, and supine, and determine if an association exists between ulnar groove morphology and tendon position in asymptomatic volunteers. Axial proton density-weighted MR was performed through the distal radioulnar joint with the forearm prone, neutral, and supine in 38 asymptomatic wrists. The percentage of the tendon located beyond the ulnar-most border of the ulnar groove was recorded. Ulnar groove depth and length was measured and ECU tendon signal was assessed. 15.8 % of tendons remained within the groove in all forearm positions. In 76.3 %, the tendon translated medially from prone to supine. The tendon &apos;'dislocated'&apos; in 0, 10.5, and 39.5 % with the forearm prone, neutral and supine, respectively. In 7.9 % prone, 5.3 % neutral, and 10.5 % supine exams, the tendon was 51-99 % beyond the ulnar border of the ulnar groove. Mean ulnar groove depth and length were 1.6 and 7.7 mm, respectively, with an overall trend towards greater degrees of tendon translation in shorter, shallower ulnar grooves. The ECU tendon shifts in a medial direction when the forearm is supine; however, tendon &apos;'dislocation'&apos; has not been previously documented in asymptomatic volunteers. The ECU tendon medially translated or frankly dislocated from the ulnar groove in the majority of our asymptomatic volunteers, particularly when the forearm is supine. Overall greater degrees of tendon translation were observed in shorter and shallower ulnar grooves. (orig.)

  17. Students&apos;, Guardians&apos;, and Teachers&apos; Perceptions of Student-Led Conferences

    Science.gov (United States)

    Orso, Charlotte Lindsey

    2013-01-01

    The purpose of the study was to examine the ELL and non-ELL students&apos;, guardians&apos;, and the English as a second language (ESL) teachers&apos; perceptions of student-led conferences. Specifically, the study examined if ELL students&apos; and guardians&apos; preferences were similar to non-ELL students&apos; and guardians&apos; preferences…

  18. Genital sores - male

    Science.gov (United States)

    Sores - male genitals; Ulcers - male genitals ... A common cause of male genital sores are infections that are spread through sexual contact, such as: Genital herpes (small, painful blisters filled with clear ...

  19. Nuclear scanning in necrotizing progressive &apos;'malignant'&apos; external otitis

    Energy Technology Data Exchange (ETDEWEB)

    Parisier, S.C.; Lucente, F.E.; Som, P.M.; Hirschman, S.Z.; Arnold, L.M.; Roffman, J.D.

    1982-09-01

    The usefulness of radionuclear scanning in the treatment of 18 patients with necrotizing progressive &apos;'malignant'&apos; external otitis is discussed. A Tc 99-m bone scan, a valuable test since results are positive in early cases of osteomyelitis of the temporal bone and base of skull, showed increased uptake in all 18 patients. In 6 patients, Ga-67 citrate scans were obtained at the start of therapy and at 5-6 week intervals thereafter. The serial gallium scans were useful in evaluating the effectiveness of therapy since the uptake decrease with control of infection.

  20. The human apoE7 and apoE4 transgenic mice models

    Institute of Scientific and Technical Information of China (English)

    孙明增; 琦祖和

    2001-01-01

    To scrutinize the disorders caused by human mutant apoE7/apoE4, human apoE4 and E7 transgenic mice were established with microinjection technique to examine molecular genetic phenomena in vivo. The integration and expression of h-apoE mutant genes in transgenic mice were determined with Southern blot, Northern blot and ELISA. The current studies indicated that the transgenes and the phenotypes regarding expression of transgenes could be transmitted stably in transgenic lines. The levels of serum lipid in transgenic mice showed the characteristics of hyperlipidemia. Besides, behavior tests demonstrated the degeneration of learning and memory in transgenic mice. Short life span was observed in 2 transgenic lines. After fed with high lipid food high serum lipid was found both in normal and transgenic mice, but their mechanism regulating lipid metabolism was different. It was also verified that the human apoE mutants located at either N-terminal or C-terminal had the same pathogenesis regarding disorders of lipid metabolism in murine.

  1. Coral bleaching and ocean &apos;&apos;hot spots&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Goreau, T.J. (Global Coral Reef Alliance, Chappaqua, NY (United States)); Hayes, R.L. (Howard Univ., Washington, DC (United States). College of Medicine)

    1994-05-01

    Global sea-surface temperature maps show that mass coral-reef bleaching episodes between 1983 and 1991 followed positive anomalies more than 1 deg C above long-term monthly averages (&apos;&apos;hot spots&apos;&apos;) during the preceding warm season. Irregular formation, movement, and disappearance of hot spots make their detailed long-term prediction impossible, but they can be tracked in real time from satellite data. Monitoring of ocean hot spots and of coral bleaching is needed if the Framework Convention of Climate Change is to meet its goal of protecting the most temperature sensitive ecosystems. 47 refs, 3 figs

  2. &apos;&apos;True believers&apos;&apos; or numerical terrorism at the nuclear power plant

    Energy Technology Data Exchange (ETDEWEB)

    Kraemer, Walter [Technical Univ. Dortmund (Germany). Faculty of Statistics; Arminger, Gerhard [Bergische Univ. Wuppertal (Germany). Schumpeter School of Business and Economics

    2010-09-15

    For decades, there has been a heated debate about whether or not nuclear power plants contribute to childhood cancer in their respective neighbourhoods, with statisticians testifying on both sides. The present paper points to some flaws in the pro-arguments, taking a recent study prepared for the political party &apos;&apos;Buendnis 90 / Gruene&apos;&apos; as a specimen. Typical mistakes include an understatement of the size of tests of significance, disregard of important covariates and extreme reliance on very few selected data points.

  3. The &apos;&apos;Kinetic Stabilizer&apos;&apos;: A Simpler Tandem Mirror Confinement?

    Energy Technology Data Exchange (ETDEWEB)

    Post, R.F.

    2000-06-15

    In the search for better approaches to magnetic fusion it is important to keep in mind the lessons learned in the 50 years that fusion plasma confinement has been studied. One of the lessons learned is that &apos;'closed'&apos; and &apos;'open'&apos; fusion devices differ fundamentally with respect to an important property of their confinement, as follows: Without known exception closed systems such as the tokamak, the stellarator, or the reversed-field pinch, have been found to have their confinement times limited by non-classical, i.e., turbulence-related, processes, leading to the requirement that such systems must be scaled-up in dimensions to sizes much larger than would be the case in the absence of turbulence. By contrast, from the earliest days of fusion research, it has been demonstrated that open magnetic systems of the mirror variety can achieve confinement times close to that associated with classical, i.e., collisional, processes. While these good results have been obtained in both axially symmetric fields and in non-axisymmetric fields, the clearest cases have been those in which the confining fields are solenoidal and axially symmetric. These observations, i.e., of confinement not enhanced by turbulence, can be traced theoretically to such factors as the absence of parallel currents in the plasma, and to the constraints on particle drifts imposed by the adiabatic invariants governing particle confinement in axisymmetric open systems. In the past the MHD instability of axially symmetric open systems has been seen as a barrier to their use. However, theory predicts MHD-stable confinement is achievable if sufficient plasma is present in the &apos;&apos;good curvature&apos;&apos; regions outside the mirrors. This theory has been confirmed by experiments on the Gas Dynamic Trap mirror-based experiment at Novosibirsk, In this paper a new way of exploiting this stabilizing principle, involving creating a localized &apos;&apos

  4. Criteria of transformation of object &apos;'Ukryttya'&apos; in environmentally safe system

    International Nuclear Information System (INIS)

    The analysis of criteria of division of radioactive wastes (RAW) of object &apos;'Ukryttya'&apos; is executed on short-lived and long-lived, and their activity. It is shown that to short-lived RAW underactive belong and insignificant part of me-dium-activity waste. Hundreds of thousands of m3 of RAW on overhead marks belong to long-lived medium-activity wastes. Organization of burial place of such wastes in stable geological structures is an unrealistic task. It is suggested to create the special depository for such RAW, and buried in stable geological structures high-activity wastes only

  5. Role of glaciers in watershed hydrology: &apos;&apos;Himalayan catchment&apos;&apos; perspective

    Directory of Open Access Journals (Sweden)

    R. J. Thayyen

    2009-07-01

    Full Text Available A large number of Himalayan glacier catchments are under the influence of humid climate with snowfall in winter (November–April and South-West monsoon in summer (June–September dominating the regional hydrology. Such catchments are defined as &apos;&apos;Himalayan catchment&apos;&apos;, where the glacier melt water contributes to the river flow during the period of annual high flows produced by the monsoon. Other two major glacio-hydrological regimes of the Himalaya are winter snow dominated Alpine catchments of the Kashmir and Karakoram region and cold-arid regions of the Ladakh mountain range. Factors influencing the river flow variations in a &apos;&apos;Himalayan catchment&apos;&apos; were studied in a micro scale glacier catchment in the Garhwal Himalaya, covering an area of 77.8 km2. Discharge data generated from three hydrometric stations established at different altitudes of the Din Gad stream during the summer ablation period of 1998, 1999, 2000, 2001, 2003 and 2004. These data has been analysed along with winter/summer precipitation, temperature and mass balance data of the Dokriani glacier to study the role of the glacier and precipitation in determining the runoff variations along the stream continuum from the glacier snout to 2360 m a.s.l. Study shows that the inter-annual runoff variations in a &apos;&apos;Himalayan glacier catchment&apos;&apos; is directly linked with the precipitation rather than mass balance changes of the glacier. Study suggest that warming induced initial increase of glacier degraded runoff and subsequent decline is a glaciers mass balance response and cannot be translated as river flow response in a &apos;&apos;Himalayan catchment&apos;&apos; as suggested by the IPCC, 2007. Study also suggest that the glacier runoff critically influence the headwater river flows during the years of low summer discharge and proposes that the Himalayan catchment could experience higher river flows and positive

  6. Improved Security Via &apos;&apos;Town Crier&apos;&apos; Monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Johnston, R. G.; Garcia, A. R. E.; Pacheco, A. N.

    2003-02-26

    Waste managers are increasingly expected to provide good security for the hazardous materials they marshal. Good security requires, among other things, effective tamper and intrusion detection. We have developed and demonstrated a new method for tamper and intrusion detection which we call the &apos;&apos;town crier method&apos;&apos;. It avoids many of the problems and vulnerabilities associated with traditional approaches, and has significant advantages for hazardous waste transport. We constructed two rudimentary town crier prototype systems, and tested them for monitoring cargo inside a truck. Preliminary results are encouraging.

  7. Nuclear waste disposal. A wicked and highly conflict bearing societal problem; Nukleare Entsorgung. Ein &apos;'wicked'&apos; und hoechst konfliktbehaftetes Gesellschaftsproblem

    Energy Technology Data Exchange (ETDEWEB)

    Brunnengraeber, Achim; Mez, Lutz [Freie Univ. Berlin (Germany). Forschungszentrum fuer Umweltpolitik; Di Nucci, Maria Rosaria; Schreuers, Miranda [Freie Univ. Berlin (Germany)

    2012-12-15

    The final disposal of nuclear wastes is called &apos;'messy'&apos; or &apos;'wicked'&apos; in the political science literature. The highly complicated problems are characterized by a number of features such as intra- and inter-generational aspects and ethical questions. In the case of stakeholders the differences concern ideologies, interests, merits and preferences that cause conflicts. The search for solutions is complicated due to interacting political, social, ecologic, economic and technical aspects. The concepts &apos;&apos;wicked problems&apos;&apos; and &apos;'multi-level-governance'&apos; are promising approaches to solve the complicated situation.

  8. Agreement &apos;&apos;power networks and environment&apos;&apos; 2001-2003; Accord &apos;&apos;reseaux electriques et environnement&apos;&apos; 2001-2003

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-01-01

    This agreement, discussed between the French government and Electricite de France (EdF) group, proposes some engagements for the 2001-2003 era for a better environmental integration of power transmission and distribution networks. The agreement is made of two parts: 1 - public distribution networks: realization of new workmanship (medium and low voltage power lines, new lines in dense urban areas), actions on existing workmanship (consequences of December 1999 storms, aesthetical aspects, burial of the main overhead lines in wooded areas, reinforcement of EdF&apos;s environmental commitment, remedial actions for environmental &apos;black points&apos;), general measures of implementation (increasing network safety, protection of birds fauna, coordination of works); 2 - public transportation network (RTE): development and safety improvement of the public transportation network (reinforced arrangement for the establishment of regional development schemes, development of international interconnections, safety improvement of the public transportation network, RTE&apos;s environmental plan); line projects (arrangements during projects elaboration, accompanying program); long lived RTE&apos;s commitment (environmental management and ISO-14001 certification, vigilance with respect to electromagnetic fields, R and D). (J.S.)

  9. Do we need a &apos;&apos;green medicine&apos;&apos;?; Brauchen wir &apos;&apos;Gruene Medizin?&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, M.; Daschner, F.; Scherrer, M. [Universitaetsklinikum Freiburg (Germany)

    2006-07-01

    Spontaneously, we do associate &apos;&apos;green medicine&apos;&apos; with terms like naturopathy, natural healing substances, herbal active agents, homeopathy, healthy food, preventive medicine and similar things, and finally we think of ecology. This is the focus of the following article. First of all, the following question arises: Are there any environment-friendly and cost-saving alternatives to the present medicine? There is an increasing number of environment-caused diseases. Therefore, a medicine not coping with the environment is not credible. In today&apos;s medicine, for example, there are too many persistent detergents, water-polluting disinfectants, and many disposable materials. Too much water ist consumed, whereas the use of renewable energies is only limited. And too little natural healing methods are applied in diagnostics and therapy. Presently, in Germany, 16,7 million in-patients are treated in Germany, 1,16 million out-patients have surgeries in 2166 hospitals by ca. 1,1 million medical staff. All this work needs energy and materials which bring various risks to environment and the patients. During the last two decades, however, many efforts were made in the field of environment protection in medicine. There is hardly a hospital left which has not taken measures of protecting the environment. In the branch-specific quality management system KTQ (=cooperation for transparency and quality in the health system). environment protection measures are interrogated and systematically assessed.

  10. Knockout of p11 attenuates the acquisition and reinstatement of cocaine conditioned place preference in male but not in female mice.

    Science.gov (United States)

    Thanos, Panayotis K; Malave, Lauren; Delis, Foteini; Mangine, Paul; Kane, Katie; Grunseich, Adam; Vitale, Melissa; Greengard, Paul; Volkow, Nora D

    2016-07-01

    Cocaine's enhancement of dopamine signaling is crucial for its rewarding effects but its serotonergic effects are also relevant. Here we examined the role of the protein p11, which recruits serotonin 5HT1B and 5HT4 receptors to the cell surface, in cocaine reward. For this purpose we tested wild-type (WT) and p11 knockout (KO) male and female mice for cocaine conditioned place preference (CPP) and its cocaine-induced reinstatement at different abstinence times, after 8 days of extinction and 28 days of being home-caged. All mice showed significant cocaine CPP. Among males, p11KO showed lower CPP than WT; this difference was also evident after 28 days of home-cage abstinence. In contrast, in females there were no CPP differences between p11KO and WT mice at any time point tested. Cocaine priming after the 28-day home-cage abstinence period also resulted in lower cocaine conditioned motor activity in both male and female p11KO mice. These results suggest that cocaine CPP and its persistence during extinction and reinstatement are modulated in a sex-differentiated manner by p11. The lack of protein p11 confers protection from CPP on male, but not female mice, immediately after cocaine conditioning as well as after prolonged abstinence, but not after short-term withdrawal. Synapse 70:293-301, 2016. © 2016 Wiley Periodicals, Inc. PMID:26990537

  11. The &apos;mini&apos; and &apos;micro&apos; energy sources and their limitations; Les &apos;'minis'&apos; et &apos;'micros'&apos; sources d&apos;energie et leurs limites

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2004-03-01

    The &apos;Science and defense 2003&apos; colloquium took place in Paris on December 2 and 3. It was organized by the general delegation of armament (DGA), the French atomic energy commission (CEA) with the participation of the national center of scientific research (CNRS) and the French ministry of research and new technologies. The main topic was the needs and the solutions implemented in the domain of energy sources both for civil and military portable applications. This article make a general summary of the content of this colloquium only in the domain of small power energy sources: emergence of new miniaturized portable devices (phones, computers, cameras, autonomous medical systems, wireless communication systems, soldiers equipments, drones etc..), improvement of batteries energy density and price, new needs linked with new functionalities, technological challenges (energy generation and recovery systems, miniaturized fuel-cells, use of recoverable energy sources, implantation of power sources in the human body etc..), new technological files (new electrode materials, micron- or sub-micron scale mechanical and electronic components, sensors, micro-motors, transfer of microelectronics technologies, hybrid systems..), international competition. (J.S.)

  12. Methods for In-Flight Wing Shape Predictions of Highly Flexible Unmanned Aerial Vehicles: Formulation of Ko Displacement Theory

    Science.gov (United States)

    Ko, William L.; Fleischer, Van Tran

    2010-01-01

    The Ko displacement theory is formulated for a cantilever tubular wing spar under bending, torsion, and combined bending and torsion loading. The Ko displacement equations are expressed in terms of strains measured at multiple sensing stations equally spaced on the surface of the wing spar. The bending and distortion strain data can then be input to the displacement equations to calculate slopes, deflections, and cross-sectional twist angles of the wing spar at the strain-sensing stations for generating the deformed shapes of flexible aircraft wing spars. The displacement equations have been successfully validated for accuracy by finite-element analysis. The Ko displacement theory that has been formulated could also be applied to calculate the deformed shape of simple and tapered beams, plates, and tapered cantilever wing boxes. The Ko displacement theory and associated strain-sensing system (such as fiber optic sensors) form a powerful tool for in-flight deformation monitoring of flexible wings and tails, such as those often employed on unmanned aerial vehicles. Ultimately, the calculated displacement data can be visually displayed in real time to the ground-based pilot for monitoring the deformed shape of unmanned aerial vehicles during flight.

  13. Paprockého ostýnek aneb proč jej tepe Kořínek

    Czech Academy of Sciences Publication Activity Database

    Janosik-Bielski, Marek

    Praha : ARSCI, 2010, s. 295-299 ISBN 978-80-7420-008-3 R&D Projects: GA MŠk(CZ) LC546 Institutional research plan: CEZ:AV0Z90610518 Keywords : baroque * Czech * Paprocký, Bartoloměj * Kořínek, Jan Subject RIV: AI - Linguistics

  14. &apos;&apos;Measuring the Costs of Climate Change Policies&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Montgomery, W. D.; Smith, A. E.; Biggar, S. L.; Bernstein, P.M.

    2003-05-09

    Studies of the costs of climate change policies have utilized a variety of measures or metrics for summarizing costs. The leading economic models have utilized GNP, GDP, the &apos;&apos;area under a marginal cost curve,&apos;&apos; the discounted present value of consumption, and a welfare measure taken directly from the utility function of the model&apos;s representative agent (the &apos;&apos;Equivalent Variation&apos;&apos;). Even when calculated using a single model, these metrics do not necessarily give similar magnitudes of costs or even rank policies consistently. This paper discusses in non-technical terms the economic concepts lying behind each concept, the theoretical basis for expecting each measure to provide a consistent ranking of policies, and the reasons why different measures provide different rankings. It identifies a method of calculating the &apos;&apos;Equivalent Variation&apos;&apos; as theoretically superior to the other cost metrics in ranking policies. When regulators put forward new economic or regulatory policies, there is a need to compare the costs and benefits of these new policies to existing policies and other alternatives to determine which policy is most cost-effective. For command and control policies, it is quite difficult to compute costs, but for more market-based policies, economists have had a great deal of success employing general equilibrium models to assess a policy&apos;s costs. Not all cost measures, however, arrive at the same ranking. Furthermore, cost measures can produce contradictory results for a specific policy. These problems make it difficult for a policy-maker to determine the best policy. For a cost measures to be of value, one would like to be confident of two things. First one wants to be sure whether the policy is a winner or loser. Second, one wants to be confident that a measure produces the correct policy ranking. That is, one wants to have confidence in a policy measure&apos;s ability to correctly rank

  15. Is Cass&apos;s Model of Homosexual Identity Formation Relevant to Today&apos;s Society?

    Science.gov (United States)

    Kenneady, Donna Ann; Oswalt, Sara B.

    2014-01-01

    Cass&apos;s Homosexual Identity Formation Model (1979) is one of the most well-known and well-referenced models of identity development for gay males and lesbians. This article provides a review of Cass&apos;s six steps of the model, as well as research support for and critiques of the model. As the model was developed more than 30 years ago, the…

  16. Żydzi w dyskursie Kościoła katolickiego

    Directory of Open Access Journals (Sweden)

    Marzena Makuchowska

    2016-01-01

    anti-Semitism.After 1989 in Poland anti-Jewish inclinations returned, especially in the circle of the so callled Catholicism of the Maryja Radio. Again Jews are accused of causing damage to Poles, and the language of those statements is very much like in the discourse before the Council. Żydzi w dyskursie Kościoła katolickiegoArtykuł opisuje ważne zmiany w dyskursie Kościoła katolickiego w odniesieniu do wyznawców judaizmu, które pojawiły się po Soborze Watykańskim II. Jedną z nich jest różnica pomiędzy stanem tekstów w dwóch różnych momentach: przed i po soborze. Dlatego pierwszą część artykułu autorka poświęca charakterystyce przedsoborowego (i w większości przedwojennego dyskursu na temat Żydów, a część drugą – głównym kierunkom zmian spowodowanym realizacją postulatów soboru. Część trzecia pokazuje objawy kontynuacji starych, głęboko zakorzenionych schematów. Analiza częściowo odnosi się do ogólnych tekstów Kościoła, a częściowo do tekstów Kościoła publikowanych w Polsce.Polski przedsoborowy dyskurs o Żydach był wyjątkowo negatywny. Liturgia katolicka przedstawiała Żydów jako tych, którzy torturowali i zabili Jezusa (mit bogobójcy. W kazaniach, listach duszpasterskich i katolickiej prasie Żydów pokazywano jako wrogów nie tylko chrześcijan, lecz szczególnie Polaków, ponieważ Kościół w Polsce zaangażował się w kreowanie narodowo i religijnie homogenicznego kraju pod sloganem „Polska dla Polaków”. Reprodukowano wszystkie tradycyjne mity (Żydzi jako szkodnicy, spiskowcy, rozpustnicy itd. Używano wiele środków lingwistycznych, by zdegradować Żydów, np. zdrobnienia, animalizację (czyli mówienie o Żydach jako o zwierzętach czy tak zwany kakofemizm (czyli używanie słów o pejoratywnym znaczeniu, aby sprowokować uczucie moralnego i fizycznego obrzydzenia.Po Vaticanum II treści reprodukujące przedstawienie Żydów jako bogobójców zostały usunięte z liturgii. Pozytywny

  17. Role of the &apos;&apos;fountain effect&apos;&apos; in the equatorial ionosphere in the prolonged retention of radioactive products of the &apos;'Starfish'&apos; explosion at F-region altitudes

    Energy Technology Data Exchange (ETDEWEB)

    Bolyunova, A.D.

    1975-01-01

    The effect of prolonged retention of radioactive products (fission fragments) following the &apos;'Starfish'&apos; thermonuclear explosion at F-region altitudes of the ionosphere of lower and middle latitudes discovered on the Kosmos 3, Kosmos 5, and Kosmos 6 satellites is analyzed from the point of view of concepts concerning ion transport processes in the equatorial ionosphere. A qualitative explanation for this phenomenon based on the &apos;&apos;fountain effect&apos;&apos; in the equatorial ionosphere is proposed which is in satisfactory agreement with experiment.

  18. Tradeoff between smoother and sooner &apos;&apos;little rip&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Bouhmadi-Lopez, Mariam [University of the Basque Country UPV/EHU, Department of Theoretical Physics, P.O. Box 644, Bilbao (Spain); Basque Foundation for Science, IKERBASQUE, Bilbao (Spain); Chen, Pisin [National Taiwan University, Department of Physics, Taipei (China); National Taiwan University, Graduate Institute of Astrophysics, Taipei (China); National Taiwan University, Leung Center for Cosmology and Particle Astrophysics, Taipei (China); Stanford University, Kavli Institute for Particle Astrophysics and Cosmology, SLAC National Accelerator Laboratory, Stanford, CA (United States); Liu, Yen-Wei [National Taiwan University, Department of Physics, Taipei (China); National Taiwan University, Leung Center for Cosmology and Particle Astrophysics, Taipei (China)

    2013-09-15

    There exist dark-energy models that predict the occurrence of a &apos;&apos;little rip&apos;&apos;. At the point of a little rip the Hubble rate and its cosmic time derivative approach infinity, which is quite similar to the big rip singularity except that the former happens at infinite future and the latter at a finite cosmic time; both events happen in the future and at high energies. In the case of the big rip, a combination of ultra-violet and infra-red effects can smooth its doomsday. We therefore wonder if the little rip can also be smoothed in a similar way. We address the ultra-violet and infra-red effects in general relativity through a brane-world model with a Gauss-Bonnet term in the bulk and an induced gravity term on the brane. We find that the little rip is transformed in this case into a sudden singularity, or a &apos;&apos;big brake&apos;&apos;. Even though the big brake is smoother than the little rip in that the Hubble rate is finite at the event, the trade-off is that it takes place sooner, at a finite cosmic time. In our estimate, the big brake would happen at roughly 1300 Gyr. (orig.)

  19. Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer's disease.

    Science.gov (United States)

    Shinohara, Mitsuru; Murray, Melissa E; Frank, Ryan D; Shinohara, Motoko; DeTure, Michael; Yamazaki, Yu; Tachibana, Masaya; Atagi, Yuka; Davis, Mary D; Liu, Chia-Chen; Zhao, Na; Painter, Meghan M; Petersen, Ronald C; Fryer, John D; Crook, Julia E; Dickson, Dennis W; Bu, Guojun; Kanekiyo, Takahisa

    2016-08-01

    Cerebral amyloid angiopathy (CAA) often coexists with Alzheimer's disease (AD). APOE4 is a strong genetic risk factor for both AD and CAA. Sex-dependent differences have been shown in AD as well as in cerebrovascular diseases. Therefore, we examined the effects of APOE4, sex, and pathological components on CAA in AD subjects. A total of 428 autopsied brain samples from pathologically confirmed AD cases were analyzed. CAA severity was histologically scored in inferior parietal, middle frontal, motor, superior temporal and visual cortexes. In addition, subgroups with severe CAA (n = 60) or without CAA (n = 39) were subjected to biochemical analysis of amyloid-β (Aβ) and apolipoprotein E (apoE) by ELISA in the temporal cortex. After adjusting for age, Braak neurofibrillary tangle stage and Thal amyloid phase, we found that overall CAA scores were higher in males than females. Furthermore, carrying one or more APOE4 alleles was associated with higher overall CAA scores. Biochemical analysis revealed that the levels of detergent-soluble and detergent-insoluble Aβ40, and insoluble apoE were significantly elevated in individuals with severe CAA or APOE4. The ratio of Aβ40/Aβ42 in insoluble fractions was also increased in the presence of CAA or APOE4, although it was negatively associated with male sex. Levels of insoluble Aβ40 were positively associated with those of insoluble apoE, which were strongly influenced by CAA status. Pertaining to insoluble Aβ42, the levels of apoE correlated regardless of CAA status. Our results indicate that sex and APOE genotypes differentially influence the presence and severity of CAA in AD, likely by affecting interaction and aggregation of Aβ40 and apoE. PMID:27179972

  20. High energy X-ray laboratory &apos;'HEXYLab'&apos;. The new facility &apos;'HEXYTech'&apos;

    International Nuclear Information System (INIS)

    High-energy radiography is used traditionally for the detection of defects in the thick-walled, bulky components. It is also used for testing the integrity of components for civil and security related applications (containers). The combination of high-energy emitters with digital detector arrays or line cameras allows test procedures in a shorter time compared to film or higher contrast sensitivity. The high-energy X-ray laboratory HEXYLab BAM is a joint laboratory in which future users, manufacturers and scientists can initiate and develop joint development projects. The new universal manipulation system HEXYTech forms the engineering and technical base for the most diverse requirements in HEXYLab (High Energy X-raY Lab.). With a total of 13 rotary and linear axes the diverse trajectories for tube, object and detector can be programmed. So large objects with complex geometries can be examined. 2D and 3D images can be measured by simple radiography, and laminography and computed tomography. The general rules for the application of high energy radiography with digital detectors (imaging plates, Digital detector arrays) were determined within the framework of the European project &apos;'HEDRad'&apos; (High Energy Digital Radiography) and included in the standard DIN EN ISO 17636-2. This article gives an overview of the testing technology and presents the possible applications on the basis of images and experiments. (PowerPoint slides).

  1. "He Kuleana Ko Kakou": Hawaiian-Language Learners and the Construction of (Alter)Native Identities

    Science.gov (United States)

    Snyder-Frey, Alicia

    2013-01-01

    This article examines the various language ideologies and cultural models that inform Hawaiian-language learners&apos; experiences, language practices, and socio-ethnic identity as they attempt to become speakers of their heritage language. While Hawaiian-language education is often noted as a revitalization success story, and certainly is in…

  2. Ethanolic fermentation of sucrose, sugarcane juice and molasses by Escherichia coli strain ko11 and Klebsiella oxytoca strain P2 Fermentação etanólica de sacarose, caldo de cana-de-açúcar e de melaço por Escherichia coli KO11 e Klebsiella oxytoca P2

    OpenAIRE

    Gervásio P. da Silva; Elza F. Araújo; Daison O. Silva; Walter V. Guimarães

    2005-01-01

    Escherichia coli KO11 and Klebsiella oxytoca P2 recombinants fermented sucrose to ethanol. In minimal medium with 2% or 12% added sucrose KO11 produced 75% and 41%, respectively, of the maximum theoretical yield (0.54g ethanol/g sucrose). In Luria-Bertani (LB) broth with up to 8% sucrose, KO11 presented a 94-96% yield and with 12% sucrose, KO11 presented about 69% yield (44.5g ethanol/L). P2 presented 55% of the theoretical maximum yield in minimal medium supplemented with 2% sucrose and 47% ...

  3. Orbit as a Mirror of Systemic Disease; &apos;&apos; Epidemiologic, Clinical and Imaging &apos;&apos;

    Directory of Open Access Journals (Sweden)

    Aliakbar Ameri

    2009-01-01

    Full Text Available   "n1- Infectious: toxoplasmosis , toxocariasis ,TB , syphilis , leprosy , HIV , CMV. "n2- Non infectous: endocrine, diabetes, thyroid, connective tissue disease &apos;&apos;RA, SLE, wegeners, PAN, systemic sclerosis&apos;&apos;, vasculitides, GCA&apos;&apos;, sarcoidosis, behcet&apos;s disease, vogt koyangi harada syndrome, phakomatoses. "nAll diseases should be demonstrated by clinical images and imaging slides. "n-imaging "nX-RAY, high frequency US and color doppler, 2D and 3D X-RAY CT, MRI: "n1- X-RAY: in fractures, foreign bodies, skull combined anomalies and few other cases. "n2-High-frequency ultrasound for posterior chamber and ciliary body micro-anatomic changes &apos;&apos; tumors granulations&apos;&apos;. "nColor Doppler study for vascular lesions, central retin artery, tumors in the globe and retrobulbar region. "n3- X-RAY CT for tumors, 2D and 3D for fractures, 3D for bone anatomy, foreign body &apos;&apos; modality of choice is 2directional 2D CT scan &apos;&apos;, sino-nasal diseases, CT-angiography or phlebography in large vessel evaluation, DSA for small vessel anatomy. "n4- MRI for tumors and infection also granulation process. "nMRI and MRV in large vessel anatomy, functional – MRI for the visual pathway, tractography. "nConclusion : "nModality of choice : "n1- CT for foreign bodies &apos;&apos; MRI is contra-indicated in the first step specially in metallic fragments &apos;&apos;. CT for micro-calcification &apos;&apos; retinoblastoma &apos;&apos;,CT for fractures. "n2- MRI for tumors, biometry, soft tissue disease and functional imaging. "n3- DSA for vascular disease of the eye. "n4- U.S for biometery, posterior Chamber, iris and ciliary body lesions. 5- Fluorescein angiography for the retina.  

  4. Chronic stress does not further exacerbate the abnormal psychoneuroendocrine phenotype of Cbg-deficient male mice.

    Science.gov (United States)

    de Medeiros, Gabriela F; Minni, Amandine M; Helbling, Jean-Christophe; Moisan, Marie-Pierre

    2016-08-01

    Chronic stress leads to a dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis which can constitute a base for pathophysiological consequences. Using mice totally deficient in Corticosteroid binding globulin (CBG), we have previously demonstrated the important role of CBG in eliciting an adequate response to an acute stressor. Here, we have studied its role in chronic stress situations. We have submitted Cbg ko and wild-type (WT) male mice to two different chronic stress paradigms - the unpredictable chronic mild stress and the social defeat. Then, their impact on neuroendocrine function - through corticosterone and CBG measurement - and behavioral responses - via anxiety and despair-like behavioral tests - was evaluated. Both chronic stress paradigms increased the display of despair-like behavior in WT mice, while that from Cbg ko mice - which was already high - was not aggravated. We have also found that control and defeated (stressed) Cbg ko mice show no difference in the social interaction test, while defeated WT mice reduce their interaction time when compared to unstressed WT mice. Interestingly, the same pattern was observed for corticosterone levels, where both chronic stress paradigms lowered the corticosterone levels of WT mice, while those from Cbg ko mice remained low and unaltered. Plasma CBG binding capacity remained unaltered in WT mice regardless of the stress paradigm. Through the use of the Cbg ko mice, which only differs genetically from WT mice by the absence of CBG, we demonstrated that CBG is crucial in modulating the effects of stress on plasma corticosterone levels and consequently on behavior. In conclusion, individuals with CBG deficiency, whether genetically or environmentally-induced, are vulnerable to acute stress but do not have their abnormal psychoneuroendocrine phenotype further affected by chronic stress. PMID:27153522

  5. What do we mean by the word &apos;'Shock'&apos;?

    International Nuclear Information System (INIS)

    From one vantage point, a shock is a continuous but drastic change in state variables that occurs over very small time and length scales. These scales and associated changes in state variables can be measured experimentally. From another vantage point, a shock is a mathematical singularity consisting of instantaneous changes in state variables. This more mathematical view gives rise to analytical solutions to idealized problems. And from a third vantage point, a shock is a structure in a hydrocode prediction. Its width depends on the simulation&apos;s grid resolution and artificial viscosity. These three vantage points can be in conflict when ideas from the associated fields are combined, and yet combining them is an important goal of an integrated modeling program. This presentation explores an example of how models for real materials in the presence of real shocks react to a hydrocode&apos;s numerical shocks of finite width. The presentation will include an introduction to plasticity for the novice, an historical view of plasticity algorithms, a demonstration of how pursuing the meaning of &apos;'shock'&apos; has resulted in hydrocode improvements, and will conclude by answering some of the questions that arise from that pursuit. After the technical part of the presentation, a few slides advertising LANL&apos;s Computational Physics Student Summer Workshop will be shown.

  6. Exposure to CB-153 and p,p&apos;-DDE and human sperm chromatin integrity

    Energy Technology Data Exchange (ETDEWEB)

    Rignell-Hydbom, A.; Rylander, L.; Joensson, B.A.G.; Hagmar, L. [Dept. of Occupational and Environmental Medicine, Lund Univ. Hospital (Sweden); Giwercman, A. [Fertility Centre, Malmoe Univ. hospital (Sweden); Spano, M. [Section of Toxicology and Biomedical Sciences, ENEA Casaccia Research Centre, Rome (Italy)

    2004-09-15

    In Sweden, the consumption of fatty fish from the Baltic Sea (off the Swedish east coast) is the single most important source of exposure to persistent organochlorine pollutants (POPs). Fishermen from the east coast have averagely higher plasma levels of polychlorinated biphenyls (PCBs) and total POP derived TEQ in plasma than both west coast fishermen and men from the general population. Dichlorodiphenyl dichloroethene (p,p&apos;-DDE), a relevant biomarker for POP is still present in relatively high serum concentrations in men consuming fish from the Baltic Sea. Several studies have shown that POPs are capable of interfering with reproductive and endocrine function in animals. Human studies have shown that exposure to PCBs and polychlorinated dibenzofurans (PCDFs) has a negative effect on male reproductive function, and especially sperm motility seems vulnerable. However, studies relating to human sperm genetic integrity are few. The aim of the study was to investigate whether exposure to POP using 2,2&apos;,4,4&apos;,5,5&apos;- hexachlorobiphenyl (CB-153) and p,p&apos;-DDE as biomarkers, are associated with sperm chromatin integrity. In order to ensure a sufficient variation in POP exposure fishermen from both the Swedish east (&apos;&apos;more exposed&apos;&apos;) and west coasts (&apos;&apos;less exposed&apos;&apos;) formed the study base.

  7. Slope Stability Estimation of the Kościuszko Mound in Cracow

    Directory of Open Access Journals (Sweden)

    Wrana Bogumił

    2015-06-01

    Full Text Available In the paper, the slope stability problem of the Kościuszko Mound in Cracow, Poland is considered. The slope stability analysis was performed using Plaxis FEM program. The outer surface of the mound has complex geometry. The slope of the cone is not uniform in all directions, on the surface of the cone are pedestrian paths. Due to its complicated geometry it was impossible to do computing by Plaxis input pre-procesor. The initial element mesh was generated using Autodesk Autocad 3D and next it was updated by Plaxis program. The soil parameters were adopted in accordance with the detailed geological soil testing performed in 2012. Calculating model includes geogrids. The upper part was covered by MacMat geogrid, while the lower part of the Mound was reinforced using Terramesh Matt geogrid. The slope analysis was performed by successives reduction of φ /c parameters. The total multiplayer ΣMsf is used to define the value of the soil strength parameters. The article presents the results of slope stability before and after the rainfall during 33 days of precipitation in flood of 2010.

  8. Current Status and Performance Tests of Korea Heat Load Test Facility KoHLT-EB

    International Nuclear Information System (INIS)

    A commissioning test has been scheduled to establish the installation and preliminary performance experiments of the copper hypervapotron mockups. And a qualification test will be performed to evaluate the CuCrZr duct liner in the ITER neutral beam injection facility and the ITER first wall small-scale mockups of the semi-prototype, at up to 1.5 and 5 MW/m2 high heat flux. Also, this system will be used to test other PFCs for ITER and materials for tokamak reactors. Korean high heat flux test facility(KoHLT-EB; Korea Heat Load Test facility - Electron Beam) by using an electron beam system has been constructed in KAERI to perform the qualification test for ITER blanket FW semi-prototype mockups, hypervapotron cooling devices in fusion devices, and other ITER plasma facing components. The commissioning and performance tests with the supplier of e-gun system have been performed on November 2012. The high heat flux test for hypervapotron cooling device and calorimetry were performed to measure the surface heat flux, the temperature profile and cooling performance. Korean high heat flux test facility for the plasma facing components of nuclear fusion machines will be constructed to evaluate the performance of each component. This facility for the plasma facing materials will be equipped with an electron beam system with a 60 kV acceleration gun

  9. Extension of Ko Straight-Beam Displacement Theory to Deformed Shape Predictions of Slender Curved Structures

    Science.gov (United States)

    Ko, William L.; Fleischer, Van Tran

    2011-01-01

    The Ko displacement theory originally developed for shape predictions of straight beams is extended to shape predictions of curved beams. The surface strains needed for shape predictions were analytically generated from finite-element nodal stress outputs. With the aid of finite-element displacement outputs, mathematical functional forms for curvature-effect correction terms are established and incorporated into straight-beam deflection equations for shape predictions of both cantilever and two-point supported curved beams. The newly established deflection equations for cantilever curved beams could provide quite accurate shape predictions for different cantilever curved beams, including the quarter-circle cantilever beam. Furthermore, the newly formulated deflection equations for two-point supported curved beams could provide accurate shape predictions for a range of two-point supported curved beams, including the full-circular ring. Accuracy of the newly developed curved-beam deflection equations is validated through shape prediction analysis of curved beams embedded in the windward shallow spherical shell of a generic crew exploration vehicle. A single-point collocation method for optimization of shape predictions is discussed in detail

  10. Current Status and Performance Tests of Korea Heat Load Test Facility KoHLT-EB

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sukkwon; Jin, Hyunggon; Shin, Kyuin; Choi, Boguen; Lee, Eohwak; Yoon, Jaesung; Lee, Dongwon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kim, Duckhoi; Cho, Seungyon [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2013-05-15

    A commissioning test has been scheduled to establish the installation and preliminary performance experiments of the copper hypervapotron mockups. And a qualification test will be performed to evaluate the CuCrZr duct liner in the ITER neutral beam injection facility and the ITER first wall small-scale mockups of the semi-prototype, at up to 1.5 and 5 MW/m{sup 2} high heat flux. Also, this system will be used to test other PFCs for ITER and materials for tokamak reactors. Korean high heat flux test facility(KoHLT-EB; Korea Heat Load Test facility - Electron Beam) by using an electron beam system has been constructed in KAERI to perform the qualification test for ITER blanket FW semi-prototype mockups, hypervapotron cooling devices in fusion devices, and other ITER plasma facing components. The commissioning and performance tests with the supplier of e-gun system have been performed on November 2012. The high heat flux test for hypervapotron cooling device and calorimetry were performed to measure the surface heat flux, the temperature profile and cooling performance. Korean high heat flux test facility for the plasma facing components of nuclear fusion machines will be constructed to evaluate the performance of each component. This facility for the plasma facing materials will be equipped with an electron beam system with a 60 kV acceleration gun.

  11. Analysis of Microstructure and Mechanical Properties Changes in AA1050 Aluminum Subjected to ECAP and KoBo Processes / Analiza Zmian Mikrostruktury I Własności Mechanicznych Aluminium AA1050 Po Procesie ECAP I KoBo

    Directory of Open Access Journals (Sweden)

    Bogucki R.

    2015-12-01

    Full Text Available Analysis of the results of the microstructure and the mechanical properties change in AA1050 aluminum alloy of technical purity processed using ECAP (Equal Channel Angular Pressing and KoBo deformation methods are presented in the paper.. ECAP process was performed according to Bc scheme in the range from 1 up to 10 passes. Changes of microstructure were analyzed using scanning electrone microscope equipped with electron backscattered diffraction (EBSD system. Microstructure and fraction of high-angle grain boundaries in KoBo processed samples were similar to those observed in ECAP processed samples after four passes. The most significant microstructure refinement was observed in ECAP processed sample submitted to 10 passes. In ECAP method the systematic increase of mechanical properties was observed along with increase of deformation degree.

  12. Sustainable Agriculture: enhancing the &apos;neem cake&apos;

    International Nuclear Information System (INIS)

    The &apos;neem cake&apos; is the scrap processing of the industrial chain producing neem oil and azadirachtin. The ENEA Technical Unit Environment and Sustainable Development Innovation the Agro-Industrial System, developed a promising experiment to promote the use of &apos;neem cake&apos; as an insecticide, and fertilizer of low cost in sustainable agriculture.

  13. Parents&apos; Views of Schools&apos; Involvement Efforts

    Science.gov (United States)

    Rodriguez, Raymond J.; Blatz, Erin T.; Elbaum, Batya

    2014-01-01

    Individual and focus group interviews were conducted with 96 parents of students with disabilities in 18 schools to explore parents&apos; views of schools&apos; efforts to engage them in their child&apos;s education. A mixed-methods approach was used to identify and evaluate the relative importance of eight themes related to schools&apos; efforts…

  14. &apos;Portico&apos; in the Munich MP-tandem

    Energy Technology Data Exchange (ETDEWEB)

    Muenzer, H.; Carli, W.; Hartung, P.; Rohrer, L.; Schnitter, H.; Assmann, W.

    1986-02-15

    A &apos;'portico'&apos; was installed with the aim of preventing spark damage to column components and of increasing the terminal voltage. First experiences: no spark damage is observed, especially deconditioning of accelerating tubes by the sparks has disappeared. No significant increase in terminal voltage due to axial effects has been attained. (orig.).

  15. Both chronic treatments by epothilone D and fluoxetine increase the short-term memory and differentially alter the mood status of STOP/MAP6 KO mice. : epothilone and fluoxetine improve STOP KO memory

    OpenAIRE

    Fournet, Vincent; De Lavilléon, Gaetan; Schweitzer, Annie; Giros, Bruno; Andrieux, Annie; Martres, Marie-Pascale

    2012-01-01

    International audience Recent evidence underlines the crucial role of neuronal cytoskeleton in the pathophysiology of psychiatric diseases. In this line, the deletion of STOP/MAP6 (Stable Tubule Only Polypeptide), a microtubule-stabilizing protein, triggers various neurotransmission and behavioral defects, suggesting that STOP knockout (KO) mice could be a relevant experimental model for schizoaffective symptoms. To establish the predictive validity of such a mouse line, in which the brain...

  16. Vloga Inštituta za kovinske materiale in tehnologije pri remontnih delih v JE Krško: The role of the Institute of metals and technology in the outages of JE Krško:

    OpenAIRE

    Vojvodič-Tuma, Jelena

    1995-01-01

    Institute of metals and technology is an authorised supervising organisation for construction, test operation, start, and operation of nuclear power plant. We present Institute activities needed for releasing expertise on repeated start of reactor after outage 1995 and fuel replacement in Nuclear power plant Krško. Non - destructive methods applied on steam generators and reactor vessel head penetrations are explained, as well as an example of determination of erosion/corrosion and acceptance...

  17. The Reentry Adult College Student: An Exploration of the Black Male Experience

    Science.gov (United States)

    Rosser-Mims, Dionne; Palmer, Glenn A.; Harroff, Pamela

    2014-01-01

    This chapter shares findings from a qualitative study on reentry adult Black males&apos; postsecondary education experiences and identifies strategies to help this population matriculate through college and graduate.

  18. Effect of Blended Learning Environment Model on High School Students&apos; Academic Achievement

    Science.gov (United States)

    Kazu, Ibrahim Yasar; Demirkol, Mehmet

    2014-01-01

    This study analyzes the students&apos; academic performance by comparing the blended learning environment and traditional learning environment. It has been observed whether there is a significant difference between the academic achievement grade dispersions and the male-female students&apos; grades. The study has been carried out in Diyarbakir…

  19. Acute effects of interleukin-6 infusion on apo-B-containing lipoprotein subclasses in humans

    DEFF Research Database (Denmark)

    Bagdade, John; Pedersen, Bente K; Schwenke, Dawn;

    2011-01-01

    B:E) apoB-containing subclasses present in VLDL. Therefore, we have directly measured these subclasses following their isolation by sequential immunoprecipitation in seven healthy male subjects during a 3-h infusion with recombinant human (rh) IL-6. Though plasma TG and apoB-containing particle number were...

  20. Overview of &apos;&apos;Red Oil&apos;&apos; Frequency Analyses for F-Canyon

    Energy Technology Data Exchange (ETDEWEB)

    Lux, C.R.

    2000-07-19

    A very small potential exists in the Savannah River Site (SRS) separations operations for an uncontrolled reaction between tri-n-butyl phosphate (TBP) and nitric acid that could result in unacceptable damage to separations facilities and a significant release of radioactive materials. The recent &apos;&apos;red oil&apos;&apos; (TBP and nitric acid) accident in Tomsk, Russia, resulted in considerable damage and radioactive release. Explosions have also occurred at SRS during the early years of operations. While the SRS separations facilities have operated without incident for many years, it is prudent to revisit the SRS defense-in-depth approach to preventing such an accident and to upgrade preventive procedures and hardware as appropriate.

  1. Test Report for Acceptance Test Procedure for Pumping and Instrumentation Control Skid &apos;'K'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    JOHNS, B.R.

    1999-10-28

    This is a Test Report for Acceptance Test Procedure (ATP) HNF-4276. This test report provides the results of the inspection and testing of the new Pumping and Instrumentation Control (PIC) skid designed as &apos;'K'&apos;. The ATP was successfully completed. A copy of the completed ATP is in the Appendix of this document.

  2. Utjecaj ograničene termičke ekspanzije na primarni cjevovod Nuklearne elektrane Krško

    OpenAIRE

    Koc, Pino; Halilovič, Miroslav; Štok, Boris

    2013-01-01

    U ovom radu opisane su mehaničke analize primarnog cjevovoda Nuklearne elektrane Krško, koje obrađuju problem djelomično onemogućene termičke ekspanzije cjevovoda uslijed nedovoljnog razmaka među pločama ograničavača pomaka cijevi. Smanjenje razmaka između cijevi i pripadajućeg oslonca spriječava slobodno termičko proširenje cjevovoda tijekom zagrijavanja sistema. Time se prouzrokuju jake tlačne sile između cijevi i oslonaca, što se rezultira kao nepovoljno stanje deformacija i naprezanja i u...

  3. Model prehoda v trajnostno krožno ekonomijo v občini Kočevje

    OpenAIRE

    Pisk, Valter

    2016-01-01

    V magistrskem delu je predstavljen model prehoda v trajnostno krožno ekonomijo v občini Kočevje kot podlaga za izboljšanje gospodarskih in socialnih razmer v občini. Koncept krožnega gospodarstva temelji na načelu identifikacije in čim večjega izkoriščanja lokalnih potencialov ter dviga dodane vrednosti v lokalnem okolju z vsemi multiplikativnimi učinki, ki pri tem nastanejo. Največji razvojni potencial občine Kočevje predstavlja gozd, ki še ni izkoriščen v zadostni meri. Koncept temelji na i...

  4. Koçlarda Bazı Androlojikal Parametreler Üzerine Araştırmalar

    OpenAIRE

    AVDATEK, Fatih

    2006-01-01

    Koçlarda aşım sezonu esnasında androlojikal parametrelerden morfometrik testis ölçümleri ile spermatolojik özelliklerin belirlenmesi ve bu parametreler arasındaki ilişkinin araştırılması amacıyla yapılan bu çalışmada 4-5 yaslarında 2 Akkaraman koç materyal olarak kullanılmıştır. Hayvanların her birinden aşım sezonu esnasında haftada iki kez olmak üzere toplam10 ejekulat sperma ve araştırma başlangıcında ve sonunda olmak üzere de iki kez morfometrik testis ölçüleri alınarak d...

  5. THE FIRST &apos;&apos;WATER FOUNTAIN&apos;&apos; COLLIMATED OUTFLOW IN A PLANETARY NEBULA

    Energy Technology Data Exchange (ETDEWEB)

    Gómez, José F.; Miranda, Luis F.; Guerrero, Martín A. [Instituto de Astrofísica de Andalucía, CSIC, Glorieta de la Astronomía s/n, E-18008 Granada (Spain); Suárez, Olga; Bendjoya, Philippe; Lagadec, Eric [Laboratoire Lagrange, UMR 7293, Université de Nice Sophia-Antipolis, CNRS, Observatoire de la Côte d' Azur, F-06304 Nice (France); Rizzo, J. Ricardo; García-García, Enrique [Centro de Astrobiología (INTA-CSIC), Ctra. M-108, km. 4, E-28850 Torrejón de Ardoz (Spain); Green, James A. [CSIRO Astronomy and Space Science, Australia Telescope National Facility, P.O. Box 76, Epping, NSW 1710 (Australia); Uscanga, Lucero [Institute of Astronomy, Astrophysics, Space Applications and Remote Sensing, National Observatory of Athens, 15236 Athens (Greece); Ramos-Larios, Gerardo [Instituto de Astronomía y Meteorología, Av. Vallarta No. 2602, Col. Arcos Vallarta, C.P. 44130 Guadalajara, Jalisco (Mexico)

    2015-02-01

    &apos;&apos;Water fountains&apos;&apos; (WFs) are evolved objects showing high-velocity, collimated jets traced by water maser emission. Most of them are in the post-asymptotic giant branch (post-AGB) and they may represent one of the first manifestations of collimated mass loss in evolved stars. We present water maser, carbon monoxide, and mid-infrared spectroscopic data (obtained with the Australia Telescope Compact Array, Herschel Space Observatory, and the Very Large Telescope, respectively) toward IRAS 15103–5754, a possible planetary nebula (PN) with WF characteristics. Carbon monoxide observations show that IRAS 15103–5754 is an evolved object, while the mid-IR spectrum displays unambiguous [Ne II] emission, indicating that photoionization has started and thus, its nature as a PN is confirmed. Water maser spectra show several components spreading over a large velocity range (≅ 75 km s{sup –1}) and tracing a collimated jet. This indicates that the object is a WF, the first WF known that has already entered the PN phase. However, the spatial and kinematical distribution of the maser emission in this object are significantly different from those in other WFs. Moreover, the velocity distribution of the maser emission shows a &apos;'Hubble-like'&apos; flow (higher velocities at larger distances from the central star), consistent with a short-lived, explosive mass-loss event. This velocity pattern is not seen in other WFs (which are presumably in earlier evolutionary stages). We therefore suggest that we are witnessing a fundamental change of mass-loss processes in WFs, with water masers being pumped by steady jets in post-AGB stars, but tracing explosive/ballistic events as the object enters the PN phase.

  6. THE FIRST &apos;&apos;WATER FOUNTAIN&apos;&apos; COLLIMATED OUTFLOW IN A PLANETARY NEBULA

    International Nuclear Information System (INIS)

    &apos;&apos;Water fountains&apos;&apos; (WFs) are evolved objects showing high-velocity, collimated jets traced by water maser emission. Most of them are in the post-asymptotic giant branch (post-AGB) and they may represent one of the first manifestations of collimated mass loss in evolved stars. We present water maser, carbon monoxide, and mid-infrared spectroscopic data (obtained with the Australia Telescope Compact Array, Herschel Space Observatory, and the Very Large Telescope, respectively) toward IRAS 15103–5754, a possible planetary nebula (PN) with WF characteristics. Carbon monoxide observations show that IRAS 15103–5754 is an evolved object, while the mid-IR spectrum displays unambiguous [Ne II] emission, indicating that photoionization has started and thus, its nature as a PN is confirmed. Water maser spectra show several components spreading over a large velocity range (≅ 75 km s–1) and tracing a collimated jet. This indicates that the object is a WF, the first WF known that has already entered the PN phase. However, the spatial and kinematical distribution of the maser emission in this object are significantly different from those in other WFs. Moreover, the velocity distribution of the maser emission shows a &apos;'Hubble-like'&apos; flow (higher velocities at larger distances from the central star), consistent with a short-lived, explosive mass-loss event. This velocity pattern is not seen in other WFs (which are presumably in earlier evolutionary stages). We therefore suggest that we are witnessing a fundamental change of mass-loss processes in WFs, with water masers being pumped by steady jets in post-AGB stars, but tracing explosive/ballistic events as the object enters the PN phase

  7. Trends in Energy. &apos;The consumer decides&apos;; Trends in Energy. &apos;De consument bepaalt&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Brzezowsky-Ruys, Y.; Van der Zalm, M.; Van Zutphen, M. (eds.)

    2012-03-15

    A report is given of the Capgemini organised congress &apos;Trends in Energy 2011&apos; which has the Dutch subtitle &apos;De consument bepaalt&apos; (The consumer decides&apos;. The focus of the articles, interviews, debates and presentations is on the role of the consumer in the supply of and demand for energy. Parts of the report are in Dutch and English [Dutch] Dit rapport bestaat uit een verslag van het congres &apos;Trends in Energy 2011. De consument bepaalt&apos; en een aantal artikelen met achtergrondinformatie over onder meer de rol van de consument in vraag en aanbod van energie.

  8. Lack of Protective Osmolytes Limits Final Cell Density and Volumetric Productivity of Ethanologenic Escherichia coli KO11 during Xylose Fermentation†

    OpenAIRE

    Underwood, S. A.; Buszko, M. L.; Shanmugam, K. T.; Ingram, L. O.

    2004-01-01

    Limited cell growth and the resulting low volumetric productivity of ethanologenic Escherichia coli KO11 in mineral salts medium containing xylose have been attributed to inadequate partitioning of carbon skeletons into the synthesis of glutamate and other products derived from the citrate arm of the anaerobic tricarboxylic acid pathway. The results of nuclear magnetic resonance investigations of intracellular osmolytes under different growth conditions coupled with those of studies using gen...

  9. Antiproliferative and Proapoptotic Effects of Labisia pumila Ethanol Extract and Its Active Fraction in Human Melanoma HM3KO Cells

    OpenAIRE

    Lope Pihie, Azimahtol Hawariah; Zakaria, Zainul Amiruddin; Othman, Fezah

    2012-01-01

    The present study was to determine the anticancer potential of Labisia pumila in in vitro models. Results from the study revealed that ethanol extract of L. pumila was more cytotoxic against HM3KO cells while having reduced effects on nonmalignant cells as compared to aqueous and hexane extracts. Thus, ethanol extract was selected to be further separated by using the bioassay-guided fractionation method to give an active fraction, SF2Lp. Results obtained from the flow cytometry analysis showe...

  10. Kardiokirurg Miro Košak (1919.-2010.) i njegov doprinos razvoju kardiovaskularne kirurgije u Sloveniji

    OpenAIRE

    Zupanič Slavec, Zvonka; Slavec, Ksenija

    2011-01-01

    Kardiokirurg Miro Košak bio je pionir slovenske kardiovaskularne kirurgije, zaslužan za uvođenje najznačajnijih dostignuća iz moderne kardiovaskularne kirurgije u operacijsku praksu: 1958. izveo je prvu operaciju na otvorenom srcu primjenom izvantjelesne cirkulacije, 1965. prvu implantaciju srčanog zaliska i srčanika, a 1971. prvi je postavio premosnicu na koronarne arterije te otvorio put za prvu transplantaciju srca.

  11. Thermal-hydraulic safety analyses supporting the steam generator replacement and uprating at Krško nuclear power plant

    OpenAIRE

    Mavko, Borut; Prošek, Andrej

    2015-01-01

    The Krško nuclear power plant has undertaken a major modernization project. The objectives of the project are: long-term stabilization of the plant's operation, uprating of the net electrical power output, higher availability and enhanced safety of the plant. The modernization also requires a thorough safety re-avaluation and therefore new thermal hydraulic, mechanical and structural analysis. The thermal-hydraulic part of the safety analysis necessary for the steam generator replacement and ...

  12. Citation Analysis of The Korean Journal of Internal Medicine from KoMCI, Web of Science, and Scopus

    OpenAIRE

    Huh, Sun

    2011-01-01

    The Korean Journal of Internal Medicine (KJIM) is the international journal published in English by the Korean Association of Internal Medicine. To understand the position of the journal in three different databases, the citation indicators were elucidated. From databases such as Korean Medical Citation Index (KoMCI), Web of Science, and Scopus, citation indicators such as the impact factor, SCImago journal rank (SJR), or Hirsch Index were calculated according to the year and the results were...

  13. Comparison between &apos;slow&apos; and &apos;flash&apos; pyrolysis oils from biomass

    Energy Technology Data Exchange (ETDEWEB)

    Maggi, R.; Delmon, B. (Unite de Catalyse et Chimie des Materiaux Divises, Louvain-la-Neuve (Belgium))

    1994-05-01

    This paper presents the results obtained in the characterization of different pyrolysis oils, five oils produced by carbonization and one by flash pyrolysis. Chemical and physical properties such as density, viscosity, elemental composition, char content, water content, solubility and heating value were first determined, then an in-depth chemical characterization was carried out by liquid-liquid fractionation. A diagram indicating the separation procedure, providing four fractions (acids, bases, polars and hydrocarbons), is presented. Polar molecules which were retained in the aqueous layer (&apos;aqueous&apos; fraction) are recuperated. Each fraction wassubsequently analysed by gas chromatography-mass spectrometry (g.c.-m.s.) and Fourier transform infrared spectroscopy (FT-i.r.). The acidic fraction was the most abundant and contained essentially phenolic structures. However, phenols were differently substituted in the two types of oils; alkyl and methoxy groups in the carbonization oils; methoxy, acidic, aldehydic and ketonic functions in the flash pyrolysis oil. The other fractions present a similar composition for all oils. The basic fraction was always very small; some aromatic N-containing compounds were identified. The &apos;polar&apos; neutral fraction was also small and its characterization was very difficult. The hydrocarbon fraction, especially, was constituted of aromatics and cyclics, and some aliphatics were also identified. The &apos;aqueous&apos; fraction contained mainly carboxylic esters, alcohols and ethers. 31 refs., 4 figs., 5 tabs.

  14. Molecules with &apos;'wheels'&apos; on a metal surface

    Energy Technology Data Exchange (ETDEWEB)

    Villagomez, Carlos; Grill, Leonhard [Institut fuer Experimentalphysik, Freie Universitaet Berlin (Germany); Sasaki, Takashi; Tour, James M. [Chemistry Department, Rice University, Houston, TX (United States)

    2009-07-01

    The design and creation of molecular nanostructures with specific mechanical functions is one of the fundamental issues in nanotechnology. In this context, wheels are an interesting component for the molecular motion, because they are expected to alter the diffusion properties on surfaces, for instance by allowing only directed motion. In the presented work, we show the absorption of functional molecules studied by scanning tunneling microscopy under ultrahigh vacuum at low temperatures of about 7 K. The molecules consist of a phenyl chain, equipped with carborane side groups that represent the molecular &apos;'wheels'&apos;. Additionally, bromine atoms are attached to the terminal groups of the molecules, which should allow the covalent connection of individual molecules, according to our recently presented oen-surface-synthesis&apos;&apos; method. The high mobility of the molecules during deposition, at room temperature, enables them to form molecular nanostructures. Characteristic appearances of the molecules, due to different molecular configurations, are found. Furthermore, lateral manipulation was used to displace molecules and to probe their intermolecular interactions.

  15. [Male urinary incontinence

    NARCIS (Netherlands)

    Boer, TA de; Heesakkers, J.P.F.A.

    2008-01-01

    *Urinary incontinence in males is gaining increasingly more attention. *Male urinary incontinence can be classified as storage incontinence due to overactive bladder syndrome or stress incontinence due to urethral sphincter dysfunction. *Most patients benefit from the currently available treatment o

  16. Causes of Male Infertility

    Medline Plus

    Full Text Available ... Cessation Links to Professional Societies and Organizations Home › Causes of Male Infertility Dr. Roger Lobo of the American Society for Reproductive Medicine covers causes of male infertility. "Understanding Infertility - The Basics" is ...

  17. Male pattern baldness (image)

    Science.gov (United States)

    Male pattern baldness is a sex-linked characteristic that is passed from mother to child. A man can more accurately predict his chances of developing male pattern baldness by observing his mother's father than ...

  18. Causes of Male Infertility

    Medline Plus

    Full Text Available ... to Professional Societies and Organizations Home › Causes of Male Infertility Dr. Roger Lobo of the American Society for Reproductive Medicine covers causes of male infertility. "Understanding Infertility - The Basics" is a series ...

  19. Causes of Male Infertility

    Science.gov (United States)

    ... to Professional Societies and Organizations Home › Causes of Male Infertility Dr. Roger Lobo of the American Society for Reproductive Medicine covers causes of male infertility. "Understanding Infertility - The Basics" is a series ...

  20. Density, porosity and magnetic susceptibility of the Ko\\v{s}ice meteorite shower and homogeneity of its parent meteoroid

    CERN Document Server

    Kohout, Tomáš; Tóth, Juraj; Husárik, Marek; Gritsevich, Maria; Britt, Daniel; Borovička, Jiří; Spurný, Pavel; Igaz, Antal; Svoreň, Ján; Kornoš, Leonard; Vereš, Peter; Koza, Július; Zigo, Pavol; Gajdoš, Štefan; Világi, Jozef; Čapek, David; Krišandová, Zuzana; Tomko, Dušan; Šilha, Jiří; Schunová, Eva; Bodnárová, Marcela; Búzová, Diana; Krejčová, Tereza

    2014-01-01

    Bulk and grain density, porosity, and magnetic susceptibility of 67 individuals of Ko\\v{s}ice H chondrite fall were measured. The mean bulk and grain densities were determined to be 3.43 g/cm$^\\text{3}$ with standard deviation (s.d.) of 0.11 g/cm$^\\text{3}$ and 3.79 g/cm$^\\text{3}$ with s.d. 0.07 g/cm$^\\text{3}$, respectively. Porosity is in the range from 4.2 to 16.1%. The logarithm of the apparent magnetic susceptibility (in 10$^\\text{-9}$ m$^\\text{3}$/kg) shows narrow distribution from 5.17 to 5.49 with mean value at 5.35 with s.d. 0.08. These results indicate that all studied Ko\\v{s}ice meteorites are of the same composition down to ~g scale without presence of foreign (non-H) clasts and are similar to other H chondrites. Ko\\v{s}ice is thus a homogeneous meteorite fall derived from a homogeneous meteoroid.

  1. Source of spill ripple in the RF-KO slow-extraction method with FM and AM

    CERN Document Server

    Noda, K; Shibuya, S; Muramatsu, M; Uesugi, T; Kanazawa, M; Torikoshi, M; Takada, E; Yamada, S

    2002-01-01

    The RF-knockout (RF-KO) slow-extraction method with frequency modulation (FM) and amplitude modulation (AM) has brought high-accuracy irradiation to the treatment of a cancer tumor moving with respiration, because of a quick response to beam start/stop. However, a beam spill extracted from a synchrotron ring through RF-KO slow-extraction has a huge ripple with a frequency of around 1 kHz related to the FM. The spill ripple will disturb the lateral dose distribution in the beam scanning methods. Thus, the source of the spill ripple has been investigated through experiments and simulations. There are two tune regions for the extraction process through the RF-KO method: the extraction region and the diffusion region. The particles in the extraction region can be extracted due to amplitude growth through the transverse RF field, only when its frequency matches with the tune in the extraction region. For a large chromaticity, however, the particles in the extraction region can be extracted through the synchrotron ...

  2. Functional characterization of ent-kaurene oxidase, MtKO, from Montanoa tomentosa (Zoapatle

    Directory of Open Access Journals (Sweden)

    Villa-Ruano Nemesio

    2015-01-01

    Full Text Available Kaurene oxidases are P450 proteins that catalyze the conversion of ent-kaurene into kaurenoic acid, the final enzymatic product with a wide range of pharmacological properties. We describe the functional characterization of an ent-kaurene oxidase (EC 1.14.13.78 isolated from Montanoa tomentosa after heterologous expression in Saccharomyces cerevisiae, as well as the detection of the enzymatic activity in the plant itself. In the presence of NADPH and FAD, the microsomal fraction from transformed INVSc1 cells, ent-kaurene produced ent-kaurenoic acid, which was confirmed by GC-MS analyses. The kinetic parameters for ent-kaurene using 0.5 mg of microsomal protein were Km app= 80.63±1.2 μM and V max app= 31.80±1.8 μmol-1mg-1h-1. Optimal temperature and pH were 30°C and 7.6, respectively. Similar kinetic parameters were observed when leaf microsomes from M. tomentosa were assayed under the same conditions as for yeast microsomes. This result strongly suggests that ent-kaurene oxidase activity is present in leaf microsomes. The enzymatic activity was competitively inhibited by paclobutrazol, with IC50=43.9 μM, implying that MtKO is resistant to inhibition by azolic-type compounds. This study confirmed the biochemical detection of ent-kaurene oxidase activity in the plant, and the heterologous functionality of a cDNA with an ent-kaurene oxidase identity from M. tomentosa (zoapatle.

  3. Switzerland as Europe&apos;s &apos;'battery'&apos;. Wishful dream or reality?; Die Schweiz als &apos;&apos;Batterie Europas&apos;&apos;. Utopie oder Realitaet?

    Energy Technology Data Exchange (ETDEWEB)

    Kammer, Adrian; Zurmuehle, Damian; Salzmann, Michael; Baumgartner, Raphael; Mignone, Domenico [Bernische Kraftwerke (BKW), Bern (Switzerland). Energiewirtschaftliche Planung und Prognose

    2015-04-15

    There are plans for Swiss pumped hydrostorage systems to absorb large quantities of excess electricity from European wind and solar power generation. Model-based analyses have shown however that &apos;'Europe&apos;s battery&apos;&apos;, as Switzerland would like to see itself, will not be needed until the middle of this century. Even if all extension projects currently in progress should be completed, Switzerland will not have sufficient pump capacity or import capacity to absorb large amounts of excess electricity. Furthermore, the primary means of making storage capacity available for import electricity would be to reduce reservoir power plant capacity. In view of all this Switzerland&apos;s hopes for a role as a major European electricity storage provider appear somewhat exaggerated even in the long-term perspective.

  4. Eksperimentalna in-vitro razgradnja koštanog cementa pomoću ultrazvučnog pulzirajućeg mlaza vode za potrebe revizijske artroplastike

    OpenAIRE

    Hloch, Sergej; Foldyna, Josef; Pude, Frank; Kľoc, Ján; Zeleňák, Michal; Hvizdoš, Pavol; Monka, Peter; Smolko, Igor; Ščučka, Jiří; Kozak, Dražan; Sedmak, Aleksandar; Mihalčinová, Emília

    2015-01-01

    Članak obuhvaća studiju uporabe ultrazvučnog pulzirajućeg mlaza vode odabranih svojstava za razgradnju veze ostvarene pomoću koštanog cementa između cementiranog bedrenog drška i trabekularnog koštanog tkiva, kao potencijalne tehnike za revizijsku artroplastiku. Šest tipova komercijalnog koštanog cementa baziranog na polimetil metakrilatu rabljeni su za ovo istraživanje. Cementi su miješani uz pomoć DePuy - SmartMix® CTS / vakumske zdjele za miješanje. Mehanička svojstva ojačanog koštanog cem...

  5. Pressure effects on the intervalence-transfer band of salts of mixed-valence 1&apos;,1&apos;'&apos;-disubstituted biferrocenium cations

    Energy Technology Data Exchange (ETDEWEB)

    Sinha, U.; Lowery, M.D.; Ley, W.W.; Drickamer, H.G.; Hendrickson, D.N.

    1988-04-13

    The pressure dependence of the intervalence-transfer (IT) electronic absorption band has been determined for the mixed-valence biferrocenium and 1&apos;,1&apos;'&apos;-diethylbiferrocenium cations intercalated into a clay and for the following eight microcrystalline compounds: biferrocenium triiodide (1); biferrocenium hexafluorophosphate (2); 1&apos;,1&apos;'&apos;-diiodobiferrocenium triiodide (3); 1&apos;,1&apos;'&apos;-diiodobiferrocenium dibromoiodate (4); 1&apos;,1&apos;'&apos;-dibromobiferrocenium triiodide (5); 1&apos;,1&apos;'&apos;-dichlorobiferrocenium triiodide hemiiodine (6); 1&apos;,1&apos;'&apos;-diethylbiferrocenium triiodide (7); 1&apos;,1&apos;'&apos;-di-n-butylbiferrocenium triiodide (8). Basically three different types of pressure dependencies of the energy of the IT band are seen. Compounds 3-5, which have a solid-state packing arrangement consisting of alternating stacks of cations and anions, exhibit one type of behavior. For these three compounds the IT band shifts blue initially with pressure, and above approx. 80 kbar there is the onset of a rather abrupt reversal where the IT band shifts red with increasing pressure.

  6. &apos;&apos;Black Bone&apos;&apos; MRI: a potential alternative to CT with three-dimensional reconstruction of the craniofacial skeleton in the diagnosis of craniosynostosis

    Energy Technology Data Exchange (ETDEWEB)

    Eley, Karen A. [University of Oxford, John Radcliffe Hospital, Nuffield Department of Surgical Sciences, Oxford (United Kingdom); University of Cambridge, Addenbrookes Hospital, Department of Radiology, Cambridge (United Kingdom); Watt-Smith, Stephen R. [University of Oxford, John Radcliffe Hospital, Nuffield Department of Surgical Sciences, Oxford (United Kingdom); University College London, Eastman Dental Institute, London (United Kingdom); Sheerin, Fintan [University of Oxford, John Radcliffe Hospital, Nuffield Department of Surgical Sciences, Oxford (United Kingdom); Oxford University Hospitals NHS Trust, Oxford (United Kingdom); Golding, Stephen J. [University of Oxford, John Radcliffe Hospital, Nuffield Department of Surgical Sciences, Oxford (United Kingdom)

    2014-10-15

    To determine the potential of novel gradient echo parameters, &apos;&apos;Black Bone&apos;&apos; MRI as an alternative to CT in the identification of normal and prematurely fused cranial sutures both in 2D and 3D imaging. Thirteen children with a clinical diagnosis of craniosynostosis underwent &apos;&apos;Black Bone&apos;&apos; MRI in addition to routine cranial CT. &apos;&apos;Black Bone&apos;&apos; datasets were compared to CT and clinical findings. &apos;&apos;Black Bone&apos;&apos; imaging was subsequently used to develop 3D reformats of the craniofacial skeleton to enhance further visualisation of the cranial sutures. Patent cranial sutures were consistently identified on &apos;&apos;Black Bone&apos;&apos; MRI as areas of increased signal intensity. In children with craniosynostosis the affected suture was absent, whilst the remaining patent sutures could be visualised, consistent with CT and clinical findings. Segmentation of the &apos;&apos;Black Bone&apos;&apos; MRI datasets was successful with both threshold and volume rendering techniques. The cranial sutures, where patent, could be visualised throughout their path. Patent cranial sutures appear as areas of increased signal intensity on &apos;&apos;Black Bone&apos;&apos; MRI distinct from the cranial bone, demonstrating considerable clinical potential as a non-ionising alternative to CT in the diagnosis of craniosynostosis. (orig.)

  7. Neurotoxic metabolites of &apos;&apos;commercial hexane&apos;&apos; in the urine of shoe factory workers

    Energy Technology Data Exchange (ETDEWEB)

    Perbellini, L.; Brugnone, F.; Gaffuri, E.

    1981-12-01

    Urinary metabolites were tested in 41 shoe-factory workers exposed to a mixture of 10 solvents among which &apos;&apos;commercial hexane&apos;&apos; was the prevailing component. Cyclohexanol, 2-methyl-2-pentanol, 3-methyl-2-pentanol, and trichloroethanol were determined in connection with exposure to cyclohexane, 2-methylpentane, 3-methylpentane, and trichloroethylene, respectively. 2-Hexanol, 2,5-hexanedione, 2,5-dimethylfuran, and gamma-valerolactone were all determined in connection with n-hexane exposure only. 2,5-Hexanedione was the principal n-hexane metabolite found in the workers&apos; urine. This finding of the experimentally proven neurotoxin 2,5-hexanedione in the urine of shoe-factory workers exposed to &apos;&apos;commercial hexane&apos;&apos; is consistent with the idea that this compound is responsible for the development of neuropathy in this group of individuals.

  8. Antiferromagnetic and structural transitions in the superoxide KO2 from first principles: A 2p-electron system with spin-orbital-lattice coupling

    OpenAIRE

    Kim, MinJae; Kim, Beom Hyun; Choi, Hong Chul; B. I. Min

    2009-01-01

    KO2 exhibits concomitant antiferromagnetic (AFM) and structural transitions, both of which originate from the open-shell 2p electrons of O$_{2}^{-}$ molecules. The structural transition is accompanied by the coherent tilting of O$_{2}^{-}$ molecular axes. The interplay among the spin-orbital-lattice degrees of freedom in KO2 is investigated by employing the first-principles electronic structure theory and the kinetic-exchange interaction scheme. We have shown that the insulating nature of the...

  9. Decreasing the Level of Ethyl Acetate in Ethanolic Fermentation Broths of Escherichia coli KO11 by Expression of Pseudomonas putida estZ Esterase†

    OpenAIRE

    Hasona, Adnan; York, S W; Yomano, L. P.; Ingram, L O; Shanmugam, K T

    2002-01-01

    During the fermentation of sugars to ethanol relatively high levels of an undesirable coproduct, ethyl acetate, are also produced. With ethanologenic Escherichia coli strain KO11 as the biocatalyst, the level of ethyl acetate in beer containing 4.8% ethanol was 192 mg liter−1. Although the E. coli genome encodes several proteins with esterase activity, neither wild-type strains nor KO11 contained significant ethyl acetate esterase activity. A simple method was developed to rapidly screen bact...

  10. Analýza obchodnej vybavenosti Košíc a chovanie zákazníkov

    OpenAIRE

    Vojáčková, Zuzana

    2011-01-01

    Bachelor thesis describes the shopping facilities of Košice and consumer behaviour of local residents. It focuses on retailing, the area of foodstuffs. The first chapter briefly describes the history and current geographic and demographic state of Košice and recounts in detail the retail facilities of the city. The second chapter describes current trends in customer behaviour throughout Slovakia. The third chapter analyzes and evaluates the results of the questionnaire focused on the consumer...

  11. Response of &apos;Nagpur&apos; mandarin, &apos;Mosambi&apos; sweet orange and &apos;Kagzi&apos; acid lime to gamma radiation

    Energy Technology Data Exchange (ETDEWEB)

    Ladaniya, M.S. E-mail: mslngp@nagpur.dot.net.in; Singh, Shyam; Wadhawan, A.K

    2003-07-01

    The effects of irradiation dose and refrigerated storage conditions on &apos;Nagpur&apos; mandarin (Citrus reticulata Blanco), &apos;Mosambi&apos; sweet orange (Citrus sinensis Osbeck) and &apos;Kagzi&apos; acid lime (Citrus aurantifolia Swingle) were investigated. Mature fruits of these three species were treated with 0, 0.25, 0.5, 1 and 1.5 kGy radiation. &apos;Nagpur&apos; mandarin and &apos;Mosambi&apos; sweet oranges were stored at 6-7 deg. C and 90-95% r.h. for 75 and 90 days, respectively, while &apos;Kagzi&apos; acid limes were stored at 8{+-}1 deg. C and 90-95% r.h. for 90 days. Physico-chemical parameters, sensory attributes and respiration rate were measured besides losses and disorders. In &apos;Nagpur&apos; mandarin, radiation dose upto 1.5 kGy did not cause any rind disorder. Radiation treatments did not reduce the extent of decay. Penicillium rot was delayed in fruit treated with 1.5 kGy, while it appeared early in 0 kGy. Irradiation doses were ineffective to control rots due to Botryodiplodia theobromae and Alternaria citri. Doses upto 1.5 kGy did not cause any significant effect on fruit firmness and juice content; however, total soluble solids increased, while titratable acidity and vitamin &apos;C&apos; content decreased. Texture and flavour scores as recorded after a week, were not affected by irradiation except in 1.5 kGy. In &apos;Mosambi&apos; sweet orange, radiation treatments caused peel disorder in the form of brown sunken areas after 90 days and reduced fruit firmness, acidity and vitamin C content. The TSS content was higher in treated fruit. Flavour and texture were not affected by the doses of irradiation used. In treated acid limes (mature yellow), weight loss and decay were higher than untreated fruit (0 kGy) although difference was non-significant. Juice, TSS, titratable acidity and vitamin C contents were significantly less in treated fruit than in 0 kGy. Texture and flavour scores were also less in treated fruit than in 0 kGy. The

  12. Epidemic juvenile hypothyroidism among a population of Hanford &apos;downwinders&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Grossman, C.M.; Nussbaum, R.H.; Nussbaum, F.D. [Northwest Radiation Health Alliance, Portland, OR (United States); Kordysh, E.; Goldsmith, J.R. [Dept. of Epidemiology, Ben Gurion Univ. of the Negev, Beer Sheva (Israel)

    2001-07-01

    Self-defined &apos;downwinders&apos; responded to questionnaires as to their health and their potential exposures to emissions from the Hanford Nuclear Facility in the U.S. The area considered was between the Cascades and the Rocky Mountains, primarily to the East and Northeast of the facility. Of 801 questionnaires, returned, 518 were from women. Of these, 210 reported that they had been diagnosed by their physicians as having hypothyroidism. 31 of the 283 men had reported being diagnosed as hypothyroid. The condition is generally found to be frequent among adult women, but is uncommon in children. 54 of the 210 cases among females were diagnosed among those less than 20 years of age, and 5 out of 31 males were found in this age range. Peak years for diagnosis among females were from 1945 to 1965, with only three juvenile cases occurring after 1970 among 80 female hypothyroid cases overall. Among males there were five juvenile cases in 1955-1960 out of 7 overall, but no juvenile cases among 24 cases at other times. The timing of the onset of this epidemic follows closely after the massive release of I{sup 131} from the facility in 1945, so that a causal relationship is strongly suggested. The counties of residence of cases corresponds to the counties with high cumulative dose estimates in children&apos;s thyroid glands. Validation of the diagnostic criteria was checked in a sample of cases. Other types of thyroid abnormalities were also increased. One case of juvenile thyroid cancer was reported. While thyroid cancer in adults was unusually frequent, the first cases occurred in 1955 and the highest number (8) in 1985. Our findings are consistent with the clinical finding that hypothyroidism in children frequently follows radiation of the head and neck. Similarities with the Marshall Islanders exposed to the nuclear test, &apos;Bravo&apos; and to those exposed near Chernobyl are discussed. (orig.)

  13. Voyage reports and appraisal on CRP-ship &apos;'JUNO'&apos;. CRP sen &apos;'JUNO'&apos; no shuko jisseki to hyoka

    Energy Technology Data Exchange (ETDEWEB)

    1991-07-01

    The contra-rotating propeller (CRP) system was developed by IHI aiming at the energy saving for large size ship and installed to JUNO&apos;&apos;, a 37,000 DWT bulk carrier in January 1989. The voyage history after commissioning concerning energy-saving effect, performance after repair of ice-damage, present situation and future prospects was reported. It was revealed that the CRP-ship was superior to ordinary ships equipped with conventional propeller not only in propelling function but also in controllability of ship and such properties as propeller cavitation, pressure fluctuation, and noise. The energy saving was 15 % in comparison with conventional propeller. JUNO had an accident in St. Lawrence Bay in February 1990 during her trial voyage. The blade-tips were damaged by ice floes. However, no abnormality was observed after repairing. The voyage for one year and half proved the complete success in practical utilization of CRP system. Further improvement of technology together with the scale-up will make it possible to apply the CRP system to larger power ships such as VLCC{prime}s. The development of cleaning technology of exhaust gas from the engine has to be considered because the ship uses high sulfur content fuel oil. 15 figs.

  14. Financial and tax risks at implementation of &apos;&apos;Chayanda- Lensk&apos;&apos; section of &apos;&apos;Sila Sibiri&apos;&apos; gas transportation system construction project

    International Nuclear Information System (INIS)

    High social and economic importance of large-scale projects on gasification of East Siberian regions of Russia and diversifying gas exports poses the problem of complex risk analysis of the project. This article discusses the various types of risks that could significantly affect the timing of the implementation and effectiveness of the project for the construction of the first line of &apos;&apos;Sila Sibiri&apos;&apos;, the &apos;'Chayanda-Lensk'&apos; section. Special attention is paid to financial and tax aspects of the project. Graphically presented analysis of the dynamics of financial indicators reflect certain periods of effectiveness in implementing the project. Authors also discuss the possible causes and consequences of risks

  15. Optimal &apos;'image-based'&apos; weighting for energy-resolved CT

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, Taly Gilat [Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin 53201 (United States)

    2009-07-15

    This paper investigates a method of reconstructing images from energy-resolved CT data with negligible beam-hardening artifacts and improved contrast-to-nosie ratio (CNR) compared to conventional energy-weighting methods. Conceptually, the investigated method first reconstructs separate images from each energy bin. The final image is a linear combination of the energy-bin images, with the weights chosen to maximize the CNR in the final image. The optimal weight of a particular energy-bin image is derived to be proportional to the contrast-to-noise-variance ratio in that image. The investigated weighting method is referred to as &apos;'image-based'&apos; weighting, although, as will be described, the weights can be calculated and the energy-bin data combined prior to reconstruction. The performance of optimal image-based energy weighting with respect to CNR and beam-hardening artifacts was investigated through simulations and compared to that of energy integrating, photon counting, and previously studied optimal &apos;'projection-based'&apos; energy weighting. Two acquisitions were simulated: dedicated breast CT and a conventional thorax scan. The energy-resolving detector was simulated with five energy bins. Four methods of estimating the optimal weights were investigated, including task-specific and task-independent methods and methods that require a single reconstruction versus multiple reconstructions. Results demonstrated that optimal image-based weighting improved the CNR compared to energy-integrating weighting by factors of 1.15-1.6 depending on the task. Compared to photon-counting weighting, the CNR improvement ranged from 1.0 to 1.3. The CNR improvement factors were comparable to those of projection-based optimal energy weighting. The beam-hardening cupping artifact increased from 5.2% for energy-integrating weighting to 12.8% for optimal projection-based weighting, while optimal image-based weighting reduced the cupping to 0

  16. &apos;Crazy-Paving&apos; Patterns on High-Resolution CT Scans in Patients with Pulmonary Complications after Hematopoietic Stem Cell Transplantation

    Energy Technology Data Exchange (ETDEWEB)

    Marchiori, Edson; Escuissato, Dante L.; Gasparetto, Taisa Davaus; Considera, Daniela Peixoto [Federal University, Sao Paulo (Brazil); Franquet, Tomas [Hospital de Sant Pau, Universitat Autonoma de Barcelona, Barcelona (Spain)

    2009-02-15

    To describe the pulmonary complications following hematopoietic stem cell transplantation (HSCT) that can present with a &apos;crazy-paving&apos; pattern in high-resolution CT scans. Retrospective review of medical records from 2,537 patients who underwent HSCT. The &apos;crazy-paving&apos; pattern consists of interlobular and intralobular septal thickening superimposed on an area of ground-glass attenuation on high-resolution CT scans. The CT scans were retrospectively reviewed by two radiologists, who reached final decisions by consensus. We identified 10 cases (2.02%), seven male and three female, with pulmonary complications following HSCT that presented with the &apos;crazy-paving&apos; pattern. Seven (70%) patients had infectious pneumonia (adenovirus, herpes simplex, influenza virus, cytomegalovirus, respiratory syncytial virus, and toxoplasmosis), and three patients presented with non-infectious complications (idiopathic pneumonia syndrome and acute pulmonary edema). The &apos;crazy-paving&apos; pattern was bilateral in all cases, with diffuse distribution in nine patients (90%), predominantly in the middle and inferior lung regions in seven patients (70%), and involving the anterior and posterior regions of the lungs in nine patients (90%). The &apos;crazy-paving&apos; pattern is rare in HSCT recipients with pulmonary complications and is associated with infectious complications more commonly than non-infectious conditions.

  17. The best selled car. &apos;'Twizy'&apos; leads the sales statistics of electrically powered vehicles - a test report; Der Meistverkaufte. Renaults &apos;'Twizy'&apos; fuehrt die E-Mobil-Verkaufsstatistik an - ein Fahrbericht

    Energy Technology Data Exchange (ETDEWEB)

    Welter, Philippe

    2013-02-15

    Four wheels, two seats, one steering wheel: What does it require more for a small, electrically powered city car? Nothing, says the manufacturer. Two side windows, that is our opinion. With a maximum speed of 80 kilometers per hour and a range of 100 kilometers, the vehicle is certainly ideal for many applications over short distances in the city. PHOTON now uses the &apos;'Twizy'&apos; for almost a year, and gained consistently good experiences.

  18. The &apos;lamellated&apos; skull in. beta. -thalassaemia

    Energy Technology Data Exchange (ETDEWEB)

    Orzincolo, C. (St. Anna Hospital, Ferrara (Italy). Dept. of Radiology); Castaldi, G. (St. Maria delle Croci Hospital, Ravenna (Italy). Dept. of Medicine); Scutellari, P.N. (Ferrara Univ. (Italy). Inst. of Radiology); Franceschini, F. (Ferrara Univ. (Italy). Inst. of Medical Semeiotica)

    1989-08-01

    The skull in homozygous {beta}-thalassaemia may present several abnormalities, such as osteopenia, widening of the diploic space, and a &apos;hair-on-end&apos; appearance. In some cases it presents also a particular stratified appearance caused by a variable number of osseous lamellae, parallel with the inner table. This &apos;lamellated skull&apos; was observed in 16 out of 150 patients affected by the disease (10.6%). (orig./GDG).

  19. Aging male syndrome

    Directory of Open Access Journals (Sweden)

    Valer Donca

    2012-12-01

    Full Text Available Aging Male Syndrome is a medical condition through which men could pass between the ages of 35 and 65, when testosterone levelsin their body decline considerably. Androgen deficiency in the aging male has become a topic of increasing interest and debate throughout theworld. In contrast to female menopause, the process of aging in the male genital system is slow and highly variable between individuals. Thecharacteristic symptoms of Aging Male Syndrome include weakness, depression, fatigue and changes in body hair and skin, decreased sexualdesire, decreased lean body mass accompanied by increased visceral fat, decreased bone mineral density. Aging Male Syndrome is usually diagnosedby testing the blood for testosterone levels. The usual treatment method for Aging Male Syndrome includes testosterone injections,testosterone patches, testosterone gels and oral preparations.

  20. Proceedings of the DGMK-conference &apos;Synthesis gas chemistry&apos;. Authors&apos; manuscripts

    Energy Technology Data Exchange (ETDEWEB)

    Hoenicke, D.; Kohlpaintner, C.; Luecke, B.; Reschetilowski, W. [eds.

    2000-07-01

    The main topics of the DGMK-Conference &apos;&apos;Synthesis Gas Chemistry&apos;&apos; were: production of synthesis gas from several educts, new catalysts, Fischer-Tropsch synthesis, hydroformylation, steam reforming and carbonylation.

  1. The different grading of &apos;clean rooms&apos;; Les differents classements des &apos;&apos;salles propres&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Desjardins, C.

    2000-03-01

    The grading of clean rooms is performed according to precise criteria depending on the intended purpose of the rooms. Validation of this grading is different depending on the country. In this paper, the author proposes a synthesis of the different technical points which can give help in making a choice: grading families (particulates, biological hazards, risks, good manufacturing practices, contamination kinetics, air-flow), validation of grading (French and foreign standards, &apos;as built&apos;, &apos;at rest&apos; and &apos;operational&apos; grading), grading based on particulates (different classes, choice for a given class, consistency between definitions, extra-grading), grading based on microorganisms (efficiency of filters), grading based on air flow (integral or partial laminar flow, turbulent flow), grading based on air flow rates (different types of air, mixing ratio, new air inflow ratio). (J.S.)

  2. Male mate choice in hermit crabs: prudence by inferior males and simple preference by superior males

    OpenAIRE

    Wada, Satoshi; Arashiro, Yuusei; Takeshita, Fumio; Shibata, Yasutoki

    2011-01-01

    In species with both male-male competition and male mate choice, inferior males may make different mate choice decisions from superior males. Males of the intertidal hermit crab, Pagurus middendorffii, are known to conduct precopulatory guarding and to adjust the threshold for guarding according to social parameters, such as encounter rate with females, competitor size, and sex ratio. Larger males are stronger in male--male competition during guarding in this species. We here tested whether m...

  3. Imaging male breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Doyle, S., E-mail: sdoyle2@nhs.net [Primrose Breast Care Unit, Derriford Hospital, Plymouth (United Kingdom); Steel, J.; Porter, G. [Primrose Breast Care Unit, Derriford Hospital, Plymouth (United Kingdom)

    2011-11-15

    Male breast cancer is rare, with some pathological and radiological differences from female breast cancer. There is less familiarity with the imaging appearances of male breast cancer, due to its rarity and the more variable use of preoperative imaging. This review will illustrate the commonest imaging appearances of male breast cancer, with emphasis on differences from female breast cancer and potential pitfalls in diagnosis, based on a 10 year experience in our institution.

  4. 46,XX Male Syndrome

    Directory of Open Access Journals (Sweden)

    Bekir Uçan

    2013-06-01

    Full Text Available 46, XX male syndrome – testicular disorder of sexual differentiation (DSD is a rare condition characterized by a spectrum of clinical presentations, ranging from ambiguous to normal male genitalia. These cases are diagnosed more easily in childhood. In adults, the diagnosis can be difficult due to the current normal gender development. Here, we report hormonal, molecular and cytogenetic results in an adult male patient with primary hypogonadism who was diagnosed with 46, XX male syndrome in our clinic. Turk Jem 2013; 17: 46-8

  5. &apos;Renewable energy potentials of the coal mining sector&apos;; &apos;Regenerative Energiepotenziale des Steinkohlebergbaus&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Eikhoff, Juergen [RAG Aktiengesellschaft, Herne (Germany)

    2012-07-15

    The contribution outlines the &apos;green activities and plans&apos; of the RAG. This may be surprising in a coal mining company but perspectives must be found beyond 2018, when coal production will phase out. (orig./AKB)

  6. Progress Report: DE-FG03-97ER20274, &apos;&apos;Microbial Production of Isoprene&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Ray Fall

    2002-03-13

    We have discovered that microorganisms produce and emit the hydrocarbon isoprene (2-methyl-1,3-butadiene), and have suggested that if isoprene-producing enzymes and their genes can be harnessed, useful hydrocarbon-producing systems might be constructed. The main goal of the proposed work is to establish the biochemical mechanism and regulation of isoprene formation in the bacterial system, Bacillus subtilis. Specific objectives of the proposed work are the following: (A) to characterize the physiological regulation of isoprene formation in B. subtilis; (B) to characterize mutations in B. subtilis 168 that suppress isoprene formation, clone these genes, and determine how isoprene and isoprenoid carbon flow are regulated; and (C) to test &apos;'overflow'&apos; and &apos;'signaling'&apos; models for Bacillus isoprene formation. We are also pursuing the isolation and cloning of B. subtilis isoprene synthase, which we believe may be a regulatory enzyme.

  7. Design and implementation of a &apos;'cheese'&apos; phantom-based Tomotherapy TLD dose intercomparison

    Energy Technology Data Exchange (ETDEWEB)

    Schiefer, Hans; Buchauer, Konrad; Heinze, Simon [Medical Physics Group, Department of Radiation Oncology, St. Gallen (Switzerland); Henke, Guido; Plasswilm, Ludwig [Department of Radiation Oncology, St. Gallen (Switzerland)

    2015-11-15

    The unique beam-delivery technique of Tomotherapy machines (Accuray Inc., Sunnyvale, Calif.) necessitates tailored quality assurance. This requirement also applies to external dose intercomparisons. Therefore, the aim of the 2014 SSRMP (Swiss Society of Radiobiology and Medical Physics) dosimetry intercomparison was to compare two set-ups with different phantoms. A small cylindrical Perspex phantom, which is similar to the IROC phantom (Imaging and Radiation Oncology Core, Houston, Tex.), and the &apos;'cheese'&apos; phantom, which is provided by the Tomotherapy manufacturer to all institutions, were used. The standard calibration plans for the TomoHelical and TomoDirect irradiation techniques were applied. These plans are routinely used for dose output calibration in Tomotherapy institutions. We tested 20 Tomotherapy machines in Germany and Switzerland. The ratio of the measured (D{sub m}) to the calculated (D{sub c}) dose was assessed for both phantoms and irradiation techniques. The D{sub m}/D{sub c} distributions were determined to compare the suitability of the measurement set-ups investigated. The standard deviations of the TLD-measured (thermoluminescent dosimetry) D{sub m}/D{sub c} ratios for the &apos;'cheese'&apos; phantom were 1.9 % for the TomoHelical (19 measurements) and 1.2 % (11 measurements) for the TomoDirect irradiation techniques. The corresponding ratios for the Perspex phantom were 2.8 % (18 measurements) and 1.8 % (11 measurements). Compared with the Perspex phantom-based set-up, the &apos;'cheese'&apos; phantom-based set-up without individual planning was demonstrated to be more suitable for Tomotherapy dose checks. Future SSRMP dosimetry intercomparisons for Tomotherapy machines will therefore be based on the &apos;'cheese'&apos; phantom set-up. (orig.) [German] Die einzigartige Bestrahlungstechnik mit Tomotherapie-Bestrahlungsgeraeten (Accuray Inc., Sunnyvale, CA, USA) erfordert spezifische

  8. Regulation imposed to nuclear facility operators for the elaboration of &apos;waste studies&apos; and &apos;waste statuses&apos;; Reglementation imposee aux exploitants d&apos;installations nucleaires pour l&apos;elaboration &apos;&apos;des etudes dechets&apos;&apos; et &apos;&apos;des bilans dechets&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-09-04

    This decision from the French authority of nuclear safety (ASN) aims at validating the new versions of the guidebook for the elaboration of &apos;waste studies&apos; for nuclear facilities and of the specifications for the elaboration of &apos;waste statuses&apos; for nuclear facilities. This paper includes two documents. The first one is a guidebook devoted to nuclear facility operators which fixes the rules of production of waste studies according to the articles 20 to 26 of the inter-ministry by-law from December 31, 1999 (waste zoning conditions and ASN&apos;s control modalities). The second document concerns the specifications for the establishment of annual waste statuses according to article 27 of the inter-ministry by-law from December 31, 1999 (rational management of nuclear wastes). (J.S.)

  9. Age, APOE and sex: Triad of risk of Alzheimer's disease.

    Science.gov (United States)

    Riedel, Brandalyn C; Thompson, Paul M; Brinton, Roberta Diaz

    2016-06-01

    Age, apolipoprotein E ε4 (APOE) and chromosomal sex are well-established risk factors for late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least one APOE-ε4 allele. The sex-based prevalence of AD is well documented with over 60% of persons with AD being female. Evidence indicates that the APOE-ε4 risk for AD is greater in women than men, which is particularly evident in heterozygous women carrying one APOE-ε4 allele. Paradoxically, men homozygous for APOE-ε4 are reported to be at greater risk for mild cognitive impairment and AD. Herein, we discuss the complex interplay between the three greatest risk factors for Alzheimer's disease, age, APOE-ε4 genotype and chromosomal sex. We propose that the convergence of these three risk factors, and specifically the bioenergetic aging perimenopause to menopause transition unique to the female, creates a risk profile for AD unique to the female. Further, we discuss the specific risk of the APOE-ε4 positive male which appears to emerge early in the aging process. Evidence for impact of the triad of AD risk factors is most evident in the temporal trajectory of AD progression and burden of pathology in relation to APOE genotype, age and sex. Collectively, the data indicate complex interactions between age, APOE genotype and gender that belies a one size fits all approach and argues for a precision medicine approach that integrates across the three main risk factors for Alzheimer's disease. PMID:26969397

  10. &apos;&apos;1/f noise&apos;&apos; in music: Music from 1/f noise

    Energy Technology Data Exchange (ETDEWEB)

    Voss, R.F.; Clarke, J.

    1978-01-01

    The spectral density of fluctuations in the audio power of many musical selections and of English speech varies approximately as 1/f (f is the frequency) down to a frequency of 5 x 10/sup -4/ Hz. This result implies that the audio-power fluctuations are correlated over all times in the same manner as &apos;&apos;1/f noise&apos;&apos; in electronic components. The frequency fluctuations of music also have a 1/f spectral density at frequencies down to the inverse of the length of the piece of music. The frequency fluctuations of English speech have a quite different behavior, with a single characteristic time of about 0.1 s, the average length of a syllable. The observations on music suggest that 1/f noise is a good choice for stochastic composition. Compositions in which the frequency and duration of each note were determined by 1/f noise sources sounded pleasing. Those generated by white-noise sources sounded too random, while those generated by 1/f/sup 2/ noise sounded too correlated.

  11. OBJECTIVE BAYESIAN ANALYSIS OF &apos;'ON/OFF'&apos; MEASUREMENTS

    Energy Technology Data Exchange (ETDEWEB)

    Casadei, Diego, E-mail: diego.casadei@fhnw.ch [Visiting Scientist, Department of Physics and Astronomy, UCL, Gower Street, London WC1E 6BT (United Kingdom)

    2015-01-01

    In high-energy astrophysics, it is common practice to account for the background overlaid with counts from the source of interest with the help of auxiliary measurements carried out by pointing off-source. In this &apos;'on/off'&apos; measurement, one knows the number of photons detected while pointing toward the source, the number of photons collected while pointing away from the source, and how to estimate the background counts in the source region from the flux observed in the auxiliary measurements. For very faint sources, the number of photons detected is so low that the approximations that hold asymptotically are not valid. On the other hand, an analytical solution exists for the Bayesian statistical inference, which is valid at low and high counts. Here we illustrate the objective Bayesian solution based on the reference posterior and compare the result with the approach very recently proposed by Knoetig, and discuss its most delicate points. In addition, we propose to compute the significance of the excess with respect to the background-only expectation with a method that is able to account for any uncertainty on the background and is valid for any photon count. This method is compared to the widely used significance formula by Li and Ma, which is based on asymptotic properties.

  12. Direct detection of light &apos;'Ge-phobic'&apos; exothermic dark matter

    International Nuclear Information System (INIS)

    We present comparisons of direct dark matter (DM) detection data for light WIMPs with exothermic scattering with nuclei (exoDM), both assuming the Standard Halo Model (SHM) and in a halo model–independent manner. Exothermic interactions favor light targets, thus reducing the importance of upper limits derived from xenon targets, the most restrictive of which is at present the LUX limit. In our SHM analysis the CDMS-II-Si and CoGeNT regions become allowed by these bounds, however the recent SuperCDMS limit rejects both regions for exoDM with isospin-conserving couplings. An isospin-violating coupling of the exoDM, in particular one with a neutron to proton coupling ratio of -0.8 (which we call &apos;'Ge-phobic'&apos;), maximally reduces the DM coupling to germanium and allows the CDMS-II-Si region to become compatible with all bounds. This is also clearly shown in our halo-independent analysis

  13. Contents of 129I in radioactive water of object &apos;'Ukryttya'&apos;

    International Nuclear Information System (INIS)

    A content of 129I is certain in the radioactive water (RW) selected from the apartments of object &apos;'Ukryttya'&apos;. Activity of isotopes of iodine was determined by γ-spectrometry measuring of the faction of iodine, selected from RW on the transmitter of stable iodine. Concentration and cleaning of isotopes of iodine from present in RW of γ-emitting radionuclides of 137Cs, 154,155Eu and 241Am made by an extraction method. A volume activity of 129I in the investigational tests of RW is 5.3 ± 2.1 Bq/l. Ratio of activity in RW 90Sr/129I - (2.6 ± 1.3) · 106 and 137Cs/129I - (5.7 ± 1.8) · 106. In the tests of water directly flowing through the apartments with fuel-containing materials with the high concentration of uranium, selected from the mining hole of U-9-B, short live isotopes of iodine 131, 132, 133, 135I not found

  14. Comments on &apos;&apos;Analysis of spherical imploding shocks&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Lazarus, R.B.

    1980-04-01

    It is asserted that Fujimoto and Mishkin&apos;s article is incorrect in its claim for a pressure extremum at or behind the shock for all values of ..gamma.. and in its claim for an analytical form for the similarity exponent. (AIP)

  15. Effects of inhomogeneities on apparent cosmological observables: &apos;'fake'&apos; evolving dark energy

    Energy Technology Data Exchange (ETDEWEB)

    Romano, Antonio Enea [Kyoto University, Yukawa Institute for Theoretical Physics, Kyoto (Japan); Universidad de Antioquia, Instituto de Fisica, Medellin (Colombia); National Taiwan University, Leung Center for Cosmology and Particle Astrophysics, Taipei, Taiwan (China); The University of Tokyo, Research Centre for the Early Universe (RESCEU), Graduate School of Science, Tokyo (Japan); Starobinsky, Alexei A. [L. D. Landau Institute for Theoretical Physics, Moscow (Russian Federation); The University of Tokyo, Research Centre for the Early Universe (RESCEU), Graduate School of Science, Tokyo (Japan); Sasaki, Misao [Kyoto University, Yukawa Institute for Theoretical Physics, Kyoto (Japan)

    2012-12-15

    Using the exact Lemaitre-Bondi-Tolman solution with a non-vanishing cosmological constant {Lambda}, we investigate how the presence of a local spherically symmetric inhomogeneity can affect apparent cosmological observables, such as the deceleration parameter or the effective equation of state of dark energy (DE), derived from the luminosity distance under the assumption that the real space-time is exactly homogeneous and isotropic. The presence of a local underdensity is found to produce apparent phantom behavior of DE, while a locally overdense region leads to apparent quintessence behavior. We consider relatively small large scale inhomogeneities which today are not linear and could be seeded by primordial curvature perturbations compatible with CMB bounds. Our study shows how observations in an inhomogeneous {Lambda}CDM universe with initial conditions compatible with the inflationary beginning, if interpreted under the wrong assumption of homogeneity, can lead to the wrong conclusion about the presence of &apos;'fake'&apos; evolving dark energy instead of {Lambda}. (orig.)

  16. Absorption-line &apos;'forest'&apos; in quasar spectra, and the structure of the universe

    Energy Technology Data Exchange (ETDEWEB)

    Doroshkevich, A.G.; Muket, J.P.

    1985-05-01

    The &apos;'forest'&apos; of absorption lines observed in the spectrum of distant quasars is interpreted in light of the adiabatic (pancake) theory for the origin and evolution of structure in the universe. The hidden mass might reside in neutrino-like particles (perhaps unstable) having a rest mass of about 60--100 eV. Opportunities for testing the hypothesis observationally are discussed.

  17. 4He2+ and H2+ ion beam separation on &apos;'Sokol'&apos; IBA facility

    International Nuclear Information System (INIS)

    Two separation methods of 4He2+ and H2+ ion beams have been tested on &apos;'Sokol'&apos; IBA facility of NSC KIPT: use of existing beam-bending magnet and electrostatic analyzer, dissociation of H2+ ions when the beam passes through the carbon film. It is shown that these methods allow to decrease essentially the H2+ ion content in the 4He2+ beam.

  18. Small angle neutron scattering experiments on &apos;&apos;side-on fixed&apos;&apos; liquid crystal polyacrylates

    Energy Technology Data Exchange (ETDEWEB)

    Leroux, N. (Centre de Recherche Paul Pascal, Bordeaux-1 Univ., 33 - Pessac (France)); Keller, P. (Lab. Leon Brillouin, CEA-CNRS/CE Saclay, 91 - Gif-sur-Yvette (France)); Achard, M.F. (Centre de Recherche Paul Pascal, Bordeaux-1 Univ., 33 -Pessac (France)); Noirez, L. (Lab. Leon Brillouin, CEA-CNRS/CE Saclay, 91 -Gif-sur-Yvette (France)); Hardouin, F. (Centre de Recherche Paul Pascal, Bordeaux-1 Univ., 33 - Pessac (France))

    1993-08-01

    Small Angle Neutron Scattering experiments were carried out on liquid crystalline &apos;&apos;side-on fixed&apos;&apos; polyacrylates: we observe that the polymer backbone adopts a prolate conformation in the nematic phase. Such anisotropy of the global backbone is larger for smaller spacer lenght. In every case we measure at low temperatures a large chain extension as previously described in polysiloxanes. (orig.).

  19. MEDNARODNA PRAVNA POMOČ V KAZENSKIH ZADEVAH (TEMELJNI POJMI) S POUDARKOM NA SODELOVANJU MED REPUBLIKO SLOVENIJO IN REPUBLIKO HRVAŠKO

    OpenAIRE

    Kolbl, Marko Filip

    2014-01-01

    Predmet obravnave v mojem diplomskem delu je mednarodna pravna pomoč v kazenskih zadevah s poudarkom na sodelovanju med Republiko Slovenijo in Republiko Hrvaško, ki predstavlja obliko mednarodne kazenskopravne pomoči med dvema državama kot subjektoma kazenskopravnega sodelovanja. Kazenskopravna pomoč med državami pa je edina prava rešitev za odkrivanje in preprečevanje čezmejnega kriminala. Zato sta se Republika Slovenija in Republika Hrvaška odločili, da bosta sklenili meddržavne sporazume, ...

  20. Maßnahmen und Ansatzpunkte zur Verbesserung quantitativer Marktinformationen für den Öko-Markt

    OpenAIRE

    Rippin, M.; Schaack, D.; Willer, H.; von Koerber, H.

    2007-01-01

    Marktbeteiligte aus Politik, Wissenschaft und Wirtschaft hatten Bedarf an systematisch abrufbaren, geprüften Daten zum Öko-Markt angemeldet. In einer Projekt-Datenbank wurden die verfügbaren europäischen Strukturdaten zum gesamten und ökologischen Landbau ab 2000 zusammengeführt und so miteinander verknüpft, dass jeweils ein konsistenter Datensatz pro Land und Jahr abgerufen werden kann. Zusätzlich werden konkurrierende Angaben in einem Quellenvergleich übersichtlich dargestellt und ermöglich...

  1. Informacijski sistem za podporo odločanju za mala podjetja z ekološko prehrano

    OpenAIRE

    Peternel, Jasna

    2016-01-01

    Magistrsko delo se osredotoča na razvoj informacijskih sistemov za podporo odločanju za mala podjetja, ki se ukvarjajo z ekološko prehrano. Odločanje predstavlja ključno komponento uspešnosti podjetja, ki mora biti ustrezno podprto z informacijsko tehnologijo. Merjenje uspešnosti informacijskih sistemov (IS) postaja vse bolj pomembno. V magistrskem delu smo za merjenje uspešnosti sistema za podporo odločanju prilagodili posodobljen D&M model uspešnosti IS. Model uspešnosti IS za mala podjetja...

  2. Asiakasymmärrys koulutuspalvelun käyttöarvona : KeKo Kehittävä Koulutusohjelma

    OpenAIRE

    Tuhkanen-Mattila, Marja-Sinikka

    2014-01-01

    Arkinen asiakasymmärrys koulutuspalvelun käyttöarvona (Kehittävä Koulutus yhteistyössä yritysten kanssa, KeKo) -kehittämistehtävässä tarkastellaan, analysoidaan ja kuvataan koulutusalalla toimivan yrityksen palveluliiketoimintaa. Tavoitteena on lisätä yrityksen asiakasymmärrystä. Asiakasymmärrys sisältää käsitykset asiakaskokemuksesta ja arvoprosesseista, asiakaskannattavuudesta sekä asiakkaan osallistumisesta ja osallistamisesta. Tutkimuksen yhteydessä asiakkailta kerättiin palvelun kehitys...

  3. UTICAJ FIZIČKO-HEMIJSKIH KARAKTERISTIKA SEMENA ULJANE TIKVE (Cucurbita pepo L.) NA KVALITET I NUTRITIVNA SVOJSTVA HLADNO PRESOVANOG ULJA

    OpenAIRE

    Rabrenović, Biljana

    2012-01-01

    Hladno presovano ulje semena uljane tikve je proizvod specifičan za Srbiju, za razliku od zemaljau regionu koje imaju dugu tradiciju proizvodnje devičanskog tikvinog ulja. Tokom postupka hladnog presovanja sirovogosušenog semena uljane tikve na pužnoj presi temperatura izdvojenog ulja ne prelazi 50 oC, što se odražava na fizičko-hemijske, nutritivne i senzorne karakteristike kao i na oksidativnu stabilnost i antioksidativni potencijal ovog...

  4. Bugarsko trgovanje ljudima u Belgiji i proaktivno poduzetničko učenje: razvoj 2002. – 2009.

    OpenAIRE

    Leman, Johan; Janssens, Stef

    2010-01-01

    U radu se raspravlja o mehanizmima proaktivnog učenja u bugarsko-belgijskom trgovanju ljudima između 2002. i 2007. putem tri profila, svaki put počinjući studijom slučaja. Profili i slučajevi rezultat su dubinske analize šesnaest belgijskih sudskih spisa. Analiza otkriva tri profila: naknadno nasilno poduzetništvo u prostituciji (2002. – 2005.), međunarodno i međuetničko poduzetništvo u prostituciji (2004.) i izrabljivanje rada (2004. – 2005.). Svaki se put u poduzetnikâ može primijetiti napr...

  5. Bottom-up modelling of continuous renovation and energy balance of existing building stock: case study Kočevje

    OpenAIRE

    Šijanec Zavrl, Marjana; Stegnar, Gašper; Rakušček, Andraž; Gjerkeš, Henrik

    2016-01-01

    A dynamic bottom-up model of the building stock is developed and implemented in a case study of Kočevje urban region. In the model, national register of real estate is cross-linked to data from other registers, e.g. the energy performance certificates (EPC) and the subsidized energy renovation measures. Regular updates of the data in registers enable continual improvement of the model. Therenovation potential is determined with respect to the age of building components after the last renovati...

  6. Dehiscencija kompozitnog grafta uzlazne aorte kao odgođena komplikacija tupe povrede prsnog koša

    OpenAIRE

    Zekanović, Dražen; Carević, Vedran; Čaljkušić, Krešimir; Batinić, Tonči; Šušak, Zorislav; Fabijanić, Damir; Karlo, Robert

    2012-01-01

    65-godišnji muškarac s dakronskim tubularnim graftom uzlazne aorte i mehaničkim aortalnim zaliskom („kompozitni graft“), zaprimljen je na Neurološki odjel zbog tranzitorne ishemijske atake. Sedam mjeseci prije ove hospitalizacije, doživio je prometnu ezgodu s tupom povredom prsišta. Radiografijom prsnoga koša i ranstorakalnim ehokardiografskim pregledom učinjenim neposredno po nezgodi, nisu zabilježene patološke promjene. Prilikom prijama, bolesnik je bio bez simptoma, stabilnih hemodinamskih...

  7. Pokretanje doma za starije i nemoćne u Požeško-slavonskoj županiji

    OpenAIRE

    Asančaić, Ana; Plazibat, Olga; Vukoja, Ivan; Vukoja, Marko

    2015-01-01

    Poslovni pothvat izgradnje doma za starije i nemoćne osobe u Požeško-slavonskoj županiji temelji se na demografskom trendu starenja stanovništva i povećanog iseljavanja mladih. Uočena je povećana potreba za odgovarajućim oblicima smještaja starijih i nemoćnih osoba, koji bi korisnike zadovoljavali kvalitetom sadržaja. Na osnovi Porterovog modela pet konkurentskih snaga pokazalo se da je industrija usluge smještaja u dom umjereno atraktivna; za ulazak novih pothvata, zbog prijetnje od ulaska n...

  8. EKOLOŠKO USMERJENE TRANSPORTNE REŠITVE V PODJETJU POŠTA SLOVENIJE D.O.O.

    OpenAIRE

    Maček, Robert

    2011-01-01

    Problematika varstva okolja je iz dneva v dan pomembnejša, saj se, kronološko gledano, obdobje za korenite spremembe tako na lokalni kot tudi na globalni ravni hitro izteka. Z diplomskim delom smo želeli doprinesti k širšemu razumevanju zapletene problematike varstva okolja. Diplomsko delo je sestavljeno iz treh v celoto povezanih delov. Po opredelitvi problema v uvodu smo v prvem oziroma teoretičnem delu, opredelili transport in promet, evropsko prometno politiko in trajnostni razvoj, tra...

  9. Demografski problemi Zapadnohercegovačke županije i njihov uticaj na morfološko-funkcionalne promene naselja

    OpenAIRE

    Galić, Jelica

    2015-01-01

    U radu se razmatraju demografski problemi regije Hercegovine s posebnim osvrtom na Zapadnohercegovačku županiju te njihov uticaj na morfološko-funkcionalne promene naselja (gradova s pripadajućim naseljenim mestima) u pedesetogodišnjem   vremenskom periodu,  s naglaskom za vremenski period od  1961.  do 2011. godine.  Područje koje se analizira u ovome radu odnosi se na područje koje je funkcionalno vezano za Zapadnohercegovačku županiju, jednu od deset ...

  10. Preosjetljivost na pelud ambrozije na području Osječko-baranjske županije

    OpenAIRE

    Prus, Višnja; Čuljak, Zdenka

    2004-01-01

    Preosjetljivost dišnog sustava na peludi ovisi o dominirajućoj vrsti peludnih zrnaca u zraku za pojedinu regiju ovisno o sezoni. Očituje se kao sezonski alergijski rinokonjunktivitis i astma. Pojava i težina tegoba u linearnoj su korelaciji s koncentracijom peludi u zraku. Posljednjih godina zapažen je porast preosjetljivih na pelud ambrozije na području Osječko-baranjske županije, što se dovodi u vezu sa širenjem ovog korova, a time i porastom koncentracije peludi u zraku. Od 2001. godine pr...

  11. Oglaševanje v tiskanih medijih podjetja Pivovarna Laško d.d. na zunanjem trgu

    OpenAIRE

    Krušič, Jožica

    2016-01-01

    S pomočjo oglaševanja se vzpostavlja odnos med blagovno znamko in življenjskim stilom, ki se ujema s potrošnikovo identiteto oz. po tej identiteti hlepi. Za raziskovanje našega diplomskega dela smo si izbrali oglaševanje tiskanih medijev na tujem tržišču podjetja Pivovarna Laško. Tiskani mediji so ogroženi zaradi rasti internetnega oglaševanja. Ljudje tiskane medije dojemajo kot kredibilne, koristne za vsakdanje življenje in intelektualne, poleg tega so lahko zapomnljive vsebine tudi zane...

  12. The role of welding in the manufacture of the steam generators for the Krško nuclear power plant

    OpenAIRE

    Lešnjak, Andrej; Zorc, Borut; Tušek, Janez; Zorko, Jože; Krošelj, Franc

    2015-01-01

    This paper describes welding and cladding technologies used in the manufacture of the steam generators for the Krško nuclear power plant. The most important welded joints and claddings are treated, however, all the welded joints and claddings could not be treated because there are around 60000 in each steam generator. First cladding of the inner surface of the primary head of the steam generator is described. Submerged-arc cladding with a strip electrode was used for this purpose. Then the pr...

  13. Dijalektičko mišljenje kao mogući konstituens pedagogijskog pristupa kompetenciji

    OpenAIRE

    Komar, Zvonimir

    2010-01-01

    Pitanje o socijalnoj kompetenciji u ovome se radu postavlja u horizontu pitanja o svrsi i u tom smislu izlazišta socijalne kompetencije. Dominantna svršna određenja u trenutnom traženju određenja socijalne kompetencije koncentriraju se na pojmove poput „prilagodba”, „reakcija”, „fleksibilnost”, „zahtjevi okruženja” ili pak „funkcionalno ponašanje”. Sva su ta određenja u svojoj suštini usmjerena na konformističko postojanje i pozicionirana su heteronomno u odnosu spram zatečenoga društvenog st...

  14. Study and designing of the &apos;'caliprax'&apos; measurement bench; Etude et realisation du banc &apos;'caliprax'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Barriere, J.Ch

    2001-09-01

    Probing the matter in order to check its elementary constituents, that is the goal of the particle physic. In this field, the experiments consist in colliding highly energetic particle beams and observing the new born particles. These observations are based on big particle detectors whose running is dependant on the precise knowledge of their geometry (position of the detection chambers). To achieve this, the detectors are equipped with alignment sensors, which have to be calibrated before. This document describes the study and the making of a calibration bench for the &apos;Praxial&apos; (PRoximity AXIAL) type sensors, and other works related to these sensors. In a first part, we determine and apply a method to set the tools used to fix the sensor stands on the detection chambers. These settings are made with the use of a tridimensional measuring machine. Then, we study the stands themselves. These investigations concern mechanics: positioning quality of the sensors in their stands, bending of the supports due to the tightening. In this part too, the studies are in the field of dimensional metrology. After this, the works are reoriented toward the bench, with the choice of the displacement sensors among two different technologies: optical, with the Rasnik system, and mechanical, with linear probes as LVDT (Linear Variable Differential Transformer). Following the discovery of an ambiguity on the Rasnik system, we go on the tests to understand its behaviour. We introduce the theory of the alignment sensors calibration, which is based on a minimization calculation. The computer programs are explained in a chapter, and in an other, the implementation of the quality assurance procedures. An other part describes the mechanical studies and the problems they cause. Because of a delay onset of the project, we make a model of the bench. This dummy allows us to test every single function of the final bench. With this device, we record manually the first calibration data and

  15. Internet of &apos;'printed'&apos; Things: low-cost fabrication of autonomous sensing nodes by inkjet printing

    International Nuclear Information System (INIS)

    &apos;&apos;What if electronics devices are printed using an inkjet printer even at home?&apos;&apos; &apos;&apos;What if those devices no longer need a battery?&apos;&apos; I will introduce two enabling technologies for the Internet of Things concept. 1. Instant Inkjet Circuits: A low cost, fast and accessible technology to support the rapid prototyping of electronic devices. We demonstrated that &apos;'sintering-free'&apos; silver nano particle ink with a commodity inkjet printer can be used to fabricate printed circuit board and high-frequency applications such as antennas and sensors. The technology is now commercialized by AgIC, Inc. 2. Wireless Power: Although large amounts of data can be exchanged over a wireless communication link, mobile devices are still tethered by power cables. We are trying to solve this problem by two different approaches: energy harvesting. A simple circuitry comprised of diodes and capacitor can convert ambient radio signals into DC current. Our research revealed the signals from TV tower located 6.5km apart could be used to feed 100 microwatts to power microcontrollers

  16. Facility Management journal special feature on energy. Intelligent energy supply and air conditioning concept for the &apos;&apos;Bonner Bogen&apos;&apos; buildings; Facility Management-Special &apos;'Energie'&apos;. Intelligentes Energie- und Klimakonzept fuer den &apos;&apos;Bonner Bogen&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2009-11-15

    In the &apos;&apos;Bonner Bogen&apos;&apos; construction project, the focus was on resources-saving technology and maximum user comfort, resulting in an integrated planning and implementation process. According to the investor, BonnVisio, the technical infrastructure and energy center of the building - based on groundwater geothermal energy with aquifer storage - is unique in Germany and Europe in terms of size, mode of operation, and efficiency. (orig.)

  17. &apos;&apos;Whither Deterrence?&apos;&apos; A Brief Synopsis May, 2002

    Energy Technology Data Exchange (ETDEWEB)

    Poppe, C; Vergino, E; Barker, R; Brown, P; Gilmartin, T J; Nach, M; Sloss, L

    2002-05-29

    To most audiences, deterrence has been interconnected with nuclear weapons whose purpose had been to deter a Soviet attack. But, the Soviet Union has been gone for almost a decade. President George W. Bush has stated that Russia is not an enemy of the US and the numbers of nuclear weapons can be dramatically reduced. It is important to note that deterrence has always transcended nuclear weapons. The US&apos; first line of deterrence has been its formidable conventional warfare capability, designed to prevent conflict and win wars if necessary. The role of nuclear weapons has been to deter the,use of nuclear weapons and other weapons of mass destruction against U.S. interests during the conduct of conventional warfare and to ensure our ability to inflict massive destruction on any who would use nuclear weapons, or other weapons of mass destruction, against us. With regard to the Soviet Union, the threat of the use of nuclear weapons was a critical component of our deterrent to prevent massive Soviet conventional attack against our allies in Europe. However, the events of September 11, 2001 make clear that we have not convinced all who seek to harm us that we will be able to respond in a manner to make them wish they had not even tried. The September 11 attacks, as well as other past conflicts, do not mean that deterrence has failed-it remains effective against the threats for which it was designed. We have known there are other threats for which we did not have a credible deterrent. The challenge is to sustain deterrence against the classic threats as they evolve in technical sophistication while remaining alert to the need to evaluate continuously our ability to deter previously unforeseen challenges. How then should we be looking at deterrence as we consider fifteen or so years in the future, say to about 2015? What will be the role of nuclear weapons and other instruments of mass destruction in the future? What should the US be doing to prepare for the future? In

  18. Hematological and acute-phase responses to diet-induced obesity in IL-6 KO mice

    OpenAIRE

    Pini, Maria; Rhodes, Davina H.; Fantuzzi, Giamila

    2011-01-01

    Obesity is associated with chronic inflammation and elevated levels of IL-6. The role of IL-6 in induction of acute-phase proteins and modulation of haematological responses has been demonstrated in models of inflammation and aging, but not in obesity. We hypothesized that IL-6 is necessary to regulate the acute-phase response and hematological changes associated with diet-induced obesity (DIO) in mice. Feeding a 60% kcal/fat diet for 13 weeks to C57BL6 WT male mice induced a significant incr...

  19. Comparative study of dermal components and plasma TGF-β1 levels in Slc39a13/Zip13-KO mice.

    Science.gov (United States)

    Hirose, Takuya; Ogura, Takayuki; Tanaka, Keisuke; Minaguchi, Jun; Yamauchi, Takeshi; Fukada, Toshiyuki; Koyama, Yoh-ichi; Takehana, Kazushige

    2015-11-01

    Ehlers-Danlos syndrome (EDS) is a group of disorders caused by abnormalities that are identified in the extracellular matrix. Transforming growth factor-β1 (TGF-β1) plays a crucial role in formation of the extracellular matrix. It has been reported that the loss of function of zinc transporter ZRT/IRT-like protein 13 (ZIP13) causes the spondylocheiro dysplastic form of EDS (SCD-EDS: OMIM 612350), in which dysregulation of the TGF-β1 signaling pathway is observed, although the relationship between the dermis abnormalities and peripheral TGF-β1 level has been unclear. We investigated the characteristics of the dermis of the Zip13-knockout (KO) mouse, an animal model for SCD-EDS. Both the ratio of dermatan sulfate (DS) in glycosaminoglycan (GAG) components and the amount of collagen were decreased, and there were very few collagen fibrils with diameters of more than 150 nm in Zip13-KO mice dermis. We also found that the TGF-β1 level was significantly higher in Zip13-KO mice serum. These results suggest that collagen synthesis and collagen fibril fusion might be impaired in Zip13-KO mice and that the possible decrease of decorin level by reduction of the DS ratio probably caused an increase of free TGF-β1 in Zip13-KO mice. In conclusion, skin fragility due to defective ZIP13 protein may be attributable to impaired extracellular matrix synthesis accompanied by abnormal peripheral TGF-β homeostasis. PMID:26050750

  20. Bortezomib, C1-inhibitor and plasma exchange do not prolong the survival of multi-transgenic GalT-KO pig kidney xenografts in baboons.

    Science.gov (United States)

    Le Bas-Bernardet, S; Tillou, X; Branchereau, J; Dilek, N; Poirier, N; Châtelais, M; Charreau, B; Minault, D; Hervouet, J; Renaudin, K; Crossan, C; Scobie, L; Takeuchi, Y; Diswall, M; Breimer, M E; Klar, N; Daha, M R; Simioni, P; Robson, S C; Nottle, M B; Salvaris, E J; Cowan, P J; d'Apice, A J F; Sachs, D H; Yamada, K; Lagutina, I; Duchi, R; Perota, A; Lazzari, G; Galli, C; Cozzi, E; Soulillou, J-P; Vanhove, B; Blancho, G

    2015-02-01

    Galactosyl-transferase KO (GalT-KO) pigs represent a potential solution to xenograft rejection, particularly in the context of additional genetic modifications. We have performed life supporting kidney xenotransplantation into baboons utilizing GalT-KO pigs transgenic for human CD55/CD59/CD39/HT. Baboons received tacrolimus, mycophenolate mofetil, corticosteroids and recombinant human C1 inhibitor combined with cyclophosphamide or bortezomib with or without 2-3 plasma exchanges. One baboon received a control GalT-KO xenograft with the latter immunosuppression. All immunosuppressed baboons rejected the xenografts between days 9 and 15 with signs of acute humoral rejection, in contrast to untreated controls (n = 2) that lost their grafts on days 3 and 4. Immunofluorescence analyses showed deposition of IgM, C3, C5b-9 in rejected grafts, without C4d staining, indicating classical complement pathway blockade but alternate pathway activation. Moreover, rejected organs exhibited predominantly monocyte/macrophage infiltration with minimal lymphocyte representation. None of the recipients showed any signs of porcine endogenous retrovirus transmission but some showed evidence of porcine cytomegalovirus (PCMV) replication within the xenografts. Our work indicates that the addition of bortezomib and plasma exchange to the immunosuppressive regimen did not significantly prolong the survival of multi-transgenic GalT-KO renal xenografts. Non-Gal antibodies, the alternative complement pathway, innate mechanisms with monocyte activation and PCMV replication may have contributed to rejection. PMID:25612490

  1. Minimum joint space width (mJSW) of patellofemoral joint on standing &apos;'skyline'&apos; radiographs: test-retest reproducibility and comparison with quantitative magnetic resonance imaging (qMRI)

    Energy Technology Data Exchange (ETDEWEB)

    Simoni, Paolo; Jamali, Sanaa; Alvarez Miezentseva, Victoria [CHU de Liege, Diagnostic Imaging Departement, Domanine du Sart Tilman, Liege (Belgium); Albert, Adelin [CHU de Liege, Biostatistics Departement, Domanine du Sart Tilman, Liege (Belgium); Totterman, Saara; Schreyer, Edward; Tamez-Pena, Jose G. [Qmetrics Technologies, Rochester, NY (United States); Zobel, Bruno Beomonte [Campus Bio-Medico University, Diagnostic Imaging Departement, Rome (Italy); Gillet, Philippe [CHU de Liege, Orthopaedic surgery Department, Domanine du Sart Tilman, Liege (Belgium)

    2013-11-15

    To assess the intraobserver, interobserver, and test-retest reproducibility of minimum joint space width (mJSW) measurement of medial and lateral patellofemoral joints on standing &apos;'skyline'&apos; radiographs and to compare the mJSW of the patellofemoral joint to the mean cartilage thickness calculated by quantitative magnetic resonance imaging (qMRI). A couple of standing &apos;'skyline'&apos; radiographs of the patellofemoral joints and MRI of 55 knees of 28 volunteers (18 females, ten males, mean age, 48.5 {+-} 16.2 years) were obtained on the same day. The mJSW of the patellofemoral joint was manually measured and Kellgren and Lawrence grade (KLG) was independently assessed by two observers. The mJSW was compared to the mean cartilage thickness of patellofemoral joint calculated by qMRI. mJSW of the medial and lateral patellofemoral joint showed an excellent intraobserver agreement (interclass correlation (ICC) = 0.94 and 0.96), interobserver agreement (ICC = 0.90 and 0.95) and test-retest agreement (ICC = 0.92 and 0.96). The mJSW measured on radiographs was correlated to mean cartilage thickness calculated by qMRI (r = 0.71, p < 0.0001 for the medial PFJ and r = 0.81, p < 0.0001 for the lateral PFJ). However, there was a lack of concordance between radiographs and qMRI for extreme values of joint width and KLG. Radiographs yielded higher joint space measures than qMRI in knees with a normal joint space, while qMRI yielded higher joint space measures than radiographs in knees with joint space narrowing and higher KLG. Standing &apos;'skyline'&apos; radiographs are a reproducible tool for measuring the mJSW of the patellofemoral joint. The mJSW of the patellofemoral joint on radiographs are correlated with, but not concordant with, qMRI measurements. (orig.)

  2. &apos;Dose-painting&apos;: Myth or reality?; &apos;Dose-painting&apos;: mythe ou realite?

    Energy Technology Data Exchange (ETDEWEB)

    Supiot, S.; Paris, F. [Service de radiotherapie, centre Rene-Gauducheau, 44 - Nantes-St-Herblain (France); Centre de recherche sur le cancer Nantes-Angers (CRCNA), institut de recherche therapeutique, universite de Nantes, 44 - Nantes (France); Inserm UMR 892, 44 - Nantes (France); Lisbona, A. [Centre de recherche sur le cancer Nantes-Angers (CRCNA), institut de recherche therapeutique, universite de Nantes, 44 - Nantes (France); Inserm UMR 892, 44 - Nantes (France); Service de radiophysique, centre Rene-Gauducheau, 44 - Nantes-St-Herblain (France); Azria, D. [Service de radiotherapie, centre Val d' Aurelle Paul-Lamarque, 34 - Montpellier (France); Fenoglietto, P. [Service de radiophysique, centre Val d' Aurelle Paul-Lamarque, 34 - Montpellier (France)

    2010-10-15

    &apos;Dose-painting&apos; radiotherapy allows for a heterogeneous delivery of radiation within the tumour volume by targeting radioresistant areas defined by functional imaging. Within gross tumour volume, it is possible to define one or more target volumes based on biology (biological target volume [BTV]) and to apply a strategy of intensity modulated radiation therapy (IMRT) that will deliver a higher dose to these regions. In this review of the literature, we will highlight the biological elements responsible for radioresistance, and how to image them, then we will detail the radiotherapy techniques necessary for this approach, before presenting clinical results in various situations (head and neck tumours, prostate, brain tumours, etc.). Despite many difficulties that make dose-painting IMRT unusable in routine nowadays, biology-guided radiation therapy represents one of the major pathways of development of radiotherapy in the coming years. (authors)

  3. ApoA1, ApoJ and ApoE Plasma Levels and Genotype Frequencies in Cerebral Amyloid Angiopathy.

    Science.gov (United States)

    Montañola, Alex; de Retana, Sofía Fernández; López-Rueda, Antonio; Merino-Zamorano, Cristina; Penalba, Anna; Fernández-Álvarez, Paula; Rodríguez-Luna, David; Malagelada, Ana; Pujadas, Francesc; Montaner, Joan; Hernández-Guillamon, Mar

    2016-03-01

    The involvement of apolipoproteins, such as the ApoE4 isoform, in Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA) highlights the fact that certain lipid carriers may participate in soluble β-amyloid (Aβ) transport. Our general aim was to characterize the soluble levels of the apolipoproteins apoE, apoA1 and apoJ/clusterin and their genotype status in patients with CAA. We analyzed the genotypes frequency of APOA1 (rs5069, rs670), CLU (rs11136000, rs1532278, rs7012010, rs9331888) and APOE (rs429358, rs7412) in a cohort of patients with CAA-associated intracerebral hemorrhage (ICH) (n = 59) and compared the results with those from hypertension-associated ICH (n = 42), AD patients (n = 73) and controls (n = 88). In a subgroup of patients, we also determined the plasma concentrations of apoE, apoA1 and apoJ/clusterin. We found increased plasma apoJ/clusterin levels in CAA patients compared to AD patients or controls after adjusting for sex and age (CAA vs. controls, p = 0.033; CAA vs. AD, p = 0.013). ApoA1 levels were not altered between groups, although a strong correlation was observed between plasma Aβ(1-40) and apoA1 among CAA patients (r = 0.583, p = 0.007). Regarding plasma apoE concentration, a robust association between circulating levels and genotype status was confirmed (p < 0.001). Whereas the APOE4 frequency was higher in AD (p < 0.001) and CAA (p = 0.013), the APOA1 and CLU genotypes were not different among groups. In the CAA cohort, the risk-linked CLU variant (C) rs11136000 was associated with white matter hyperintensities (p = 0.045) and the presence of lobar microbleeds (p = 0.023) on MRI. In summary, our findings suggest that apoA1 may act as a physiological transporter of Aβ(1-40) and that apoJ/clusterin appears to be a chaperone related to distinctive lesions in CAA brains. PMID:26661731

  4. Predictors of male microchimerism

    DEFF Research Database (Denmark)

    Kamper-Jørgensen, Mads; Mortensen, Laust Hvas; Andersen, Anne-Marie Nybo;

    2012-01-01

    confounding and reverse causation. To address the issue of confounding, we conducted an analysis of predictors of male microchimerism in 272 female participants of the Danish Diet, Cancer and Health cohort. Buffy coat DNA was tested for Y chromosome presence as a marker of male microchimerism. First, we used...... logistic regression and thereafter random forest modeling to evaluate the ability of a range of reproductive, lifestyle, hospital or clinic visit history, and other variables to predict whether women tested positive for male microchimerism. We found some indication that current use of contraceptive pills...

  5. &apos;&apos;Atomic Optics&apos;&apos;: Nonimaging Optics on the Nanoscale

    Energy Technology Data Exchange (ETDEWEB)

    Roland Winston Joseph O' Gallagher

    2005-01-15

    This is the final report for a one year close out extension of our basic research program that was established at the University of Chicago more than sixteen years ago to explore and develop the optical sub-discipline that has come to be known as &apos;&apos;nonimaging optics&apos;&apos;. This program has been extremely fruitful, having both broadened the range of formalism available for workers in this field and led to the discovery of many new families of optical devices. These devices and techniques have applications wherever the efficient transport and transformation of light distributions are important, in particular in illumination, fiber optics, collection and concentration of sunlight, and the detection of faint light signals in physics and astrophysics. Over the past thirty years, Nonimaging Optics (Welford and Winston, 1989) has brought a fresh approach to the analysis of many problems in classical macro-scale optics. Through the application of phase-space concepts, statistical methods, thermodynamic arguments, etc., many previously established performance limits were able to be broken and many technical surprises with exciting practical applications were discovered. The most recent three-year phase of our long-term continuing program ended in late 2002 and emphasized extending our work in geometrical optics and expanding it to include some interesting questions in physical optics as well as in the new field of statistical optics. This report presents a survey of the basic history and concepts of nonimaging optics and reviews highlights and significant accomplishments over the past fifteen years. This is followed by a more detailed summary of recent research directions and accomplishments during the last three years. This most recent phase was marked by the broadening in scope to include a separate project involving a collaboration with an industrial partner, Science Applications International Corporation (SAIC). This effort was proposed and approved in

  6. Report of working committee 3 &apos;&apos;liquefied gases&apos;&apos;; Rapport du comite de travail 3 &apos;&apos;gaz liquefies&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Baudino, M.

    2000-07-01

    Working Committee 3&apos;s report concerns the evolution of the liquefied gas industry: both liquefied natural gas (LNG) and liquefied petroleum gases (LPG). Given the current state of the LNG market the Committee decided to concentrate on this area in particular. A number of aspects have been identified which the Committee has been looking at, while others have been given to Study Groups set up specifically for the purpose. The first aspects regard: - the development of LNG and LPG, new installations, future chains and relevant statistical data; - the role of LNG and LPG in starting up a gas industry; - operating and technological improvements in the LNG industry; - energy savings, cold utilization and reduction of CO{sub 2} emissions. The Study Groups which were set up dealt with the following subjects: Technological and Economical Developments for cost Reduction of LNG/LPG Facilities. Small Scale LNG Projects and Modular Systems. LNG/LPG Peak Shaving and Satellite Plants. LNG versus Pipeline Infrastructure. (author)

  7. Male Pattern Alopecia

    Science.gov (United States)

    ... baldness (alopecia), or androgenetic alopecia, is the patterned balding of a man. Although the condition may affect ... dihydrotestosterone – play a role in this form of balding. Who's At Risk Male pattern baldness affects many ...

  8. Causes of Male Infertility

    Medline Plus

    Full Text Available ... Smoking Cessation Links to Professional Societies and Organizations Home › Causes of Male Infertility Dr. Roger Lobo of ... Find a Health Care Provider Back to Top Home | About Us | Reproductive Health Topics | News & Publications | Resources ...

  9. Males and Eating Disorders

    Science.gov (United States)

    ... Bar Home Current Issue Past Issues Males and Eating Disorders Past Issues / Spring 2008 Table of Contents For ... this page please turn Javascript on. Photo: PhotoDisc Eating disorders primarily affect girls and women, but boys and ...

  10. Causes of Male Infertility

    Medline Plus

    Full Text Available ... and Smoking Cessation Links to Professional Societies and Organizations Home › Causes of Male Infertility Dr. Roger Lobo ... Site Terms & Conditions of Use | Web Design and Development by The Berndt Group

  11. Causes of Male Infertility

    Medline Plus

    Full Text Available ... Roger Lobo of the American Society for Reproductive Medicine covers causes of male infertility. "Understanding Infertility - The ... videos produced for the American Society for Reproductive Medicine. Looking for Additional Information? Visit our provider site ...

  12. Self catheterization - male

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000143.htm Self catheterization - male To use the sharing features on ... Read More Urinary incontinence Patient Instructions Kegel exercises - self-care Multiple sclerosis - discharge Stroke - discharge Urinary catheters - ...

  13. Cytogenetic of Male Infertility

    Directory of Open Access Journals (Sweden)

    Lutfiye Ozpak

    2011-08-01

    Full Text Available Infertility by definition, is not to get pregnant within one year of regular sexual relationship without protection, affects 15-20% of reproductive age couples. Approximately 30% of infertility cases are male originated. Male infertility is caused by endocrine-related genetic defects affecting urogenital system function. These defects adversely affect subsequent spermatogenesis, sexual function, fertility, early embryonic stage of sexual maturation. Autosomal and gonosomal, numerical and structural chromosome abnormalities and related syndromes rank at the top causes of male infertility. Similar chromosome abnormalities are detected in male infertility and as the rate of these abnormalities increase, it was found to reduce sperm count especially in azospermic and oligozoospermic men. [Archives Medical Review Journal 2011; 20(4.000: 230-245

  14. Male Reproductive System

    Science.gov (United States)

    ... Wrong With the Male Reproductive System en español Sistema reproductor masculino Reproduction All living things reproduce. Reproduction — ... cutting off its blood supply, is also a medical emergency that, thankfully, is not common. Surgery is ...

  15. Bladder catheterization, male (image)

    Science.gov (United States)

    Catheterization is accomplished by inserting a catheter (a hollow tube, often with and inflatable balloon tip) into ... catheter in place for a duration of time. Catheterization in males is slightly more difficult and uncomfortable ...

  16. Male mating biology

    OpenAIRE

    Howell Paul I; Knols Bart GJ

    2009-01-01

    Abstract Before sterile mass-reared mosquitoes are released in an attempt to control local populations, many facets of male mating biology need to be elucidated. Large knowledge gaps exist in how both sexes meet in space and time, the correlation of male size and mating success and in which arenas matings are successful. Previous failures in mosquito sterile insect technique (SIT) projects have been linked to poor knowledge of local mating behaviours or the selection of deleterious phenotypes...

  17. Male genital lichen sclerosus

    OpenAIRE

    Christopher Barry Bunker; Tang Ngee Shim

    2015-01-01

    Male genital lichen sclerosus (MGLSc) is a chronic inflammatory skin disease responsible for male sexual dyspareunia and urological morbidity. An afeared complication is squamous cell carcinoma (SCC) of the penis. The precise etiopathogenesis of MGLSc remains controversial although genetic, autoimmune and infective (such as human papillomavirus (HPV) hepatitis C (HCV), Epstein-Barr virus (EBV) and Borrelia) factors have been implicated: Consideration of all the evidence suggests that chronic ...

  18. Maling som isoleringsmateriale?

    DEFF Research Database (Denmark)

    Kiil, Søren

    2014-01-01

    I en række industrielle sammenhænge er der brug for særligt fleksible og holdbare isoleringsløsninger. Det kan f.eks. være rørledninger på havbunden, eller hulrum hvor pladsen er meget begrænset. Maling med isolerende egenskaber kan være løsningen. En matematisk model er udviklet til at simulere...... effekten af visse typer isolerende maling....

  19. An &apos;oil&apos;igopoly theory of exploration

    Energy Technology Data Exchange (ETDEWEB)

    Boyce, John R. [Department of Economics, University of Calgary, 2500 University Drive, N.W., Calgary, Alberta (Canada); Vojtassak, Lucia [Department of Economics, Trent University Peterborough, Ontario (Canada)

    2008-08-15

    This paper develops a theory of &apos;oil&apos;igopoly exploration of an exhaustible resource. Strategic exploration and production are jointly derived in a three period subgame perfect equilibrium. While the &apos;oil&apos;igopoly theory of exploration shares many features with non-strategic models of exploration and production, there is one important difference. The &apos;oil&apos;igopoly theory of exploration predicts that firms who exhaust their proved reserves before they can convert their unproved reserves into proved reserves have an incentive to over-explore, relative to the Nash equilibrium level of exploration. A simple empirical prediction is that firms holding smaller proved reserves should be observed doing more exploration. This prediction is consistent with country-level production and reserve data in the post-World War II era. (author)

  20. &apos;Fail-to-safety&apos; methane drainage system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-01-01

    Queensland-based Capricorn Coal Management and SMC Pneumatics (Australia) have developed a new methane drainage system incorporating a pneumatically controlled &apos;automatic shut down system&apos; (ASDS) that, in an emergency situation, automatically terminates the flow of gas at the source with automatic shut-off valves. The air supply unit incorporates two air compressors operating in a rotating cycle to ensure continuous supply with pressure and flow measurement sensors and solenoid valves configured to &apos;fail-to-safety&apos; in the event of power failure. The SMC-Capcoal system has been operating successfully for two years at Capcoal&apos;s Central colliery, Queensland&apos;s first longwall mine. It can shut off methane flows within 90 seconds. 3 photos.

  1. Samoprocjena i procjena ponašanja učenika s teškoćama u redovnoj osnovnoj školi

    OpenAIRE

    Igrić, Ljiljana; Wagner Jakab, Ana; Cvitković, Daniela

    2012-01-01

    Položaj djece s teškoćama u Hrvatskoj još uvijek je nepovoljan. Iako imaju pravo na individualiziran pristup, često nemaju prilike to i ostvariti. U skladu sa Bronfenbrenerovom teorijom i suvremenim pristupom prema teškoćama čini se da u cilju poboljšanja dobrobiti ove djece naglasak treba biti na sagledavanju čimbenika okoline, škole, vršnjaka, obitelji, koji utječu na učenika, a ne toliko na samoj teškoći koju dijete ima. Ovim se istraživanjem htjelo utvrditi ima li činjenica da dijete ima ...

  2. Serum Levels of ApoA1 and ApoA2 Are Associated with Cognitive Status in Older Men

    Directory of Open Access Journals (Sweden)

    Cheng Ma

    2015-01-01

    Full Text Available Background. Advancing age, chronic inflammation, oxidative damage, and disorders of lipid metabolism are positively linked to the late-life cognitive impairment. Serum biomarkers may be associated with the cognitive status in older men. Methods. 440 old male subjects with different cognitive functions were recruited to investigate probable serum markers. Pearson Chi-Squared test, univariate analysis, and multivariate logistic regression analysis were performed to evaluate biomarkers which may be associated with cognitive status. Results. Levels of fundus atherosclerosis (AS (P<0.001, age (P<0.001, serum biomarkers peroxidase (POD (P=0.026 and interleukin-6 (IL-6 (P=0.001, serum levels of high-density lipoprotein cholesterol (HDL-C (P<0.001, apolipoprotein A2 (ApoA2 (P=0.001, and ApoC2 (P=0.005 showed significant differences. Compared to group 3, ApoA1 in group 1 (OR = 1.30, 95% CI 1.01–1.67 and group 2 (OR = 1.47, 95% CI 1.11–1.94 were higher, while ApoA2 were lower (group 1: OR = 0.43, 95% CI 0.18–1.02; group 2: OR = 0.21, 95% CI 0.08–0.54 after adjusting for control variables. Conclusion. The results demonstrated that age, AS levels, POD, IL-6, HDL-C, ApoA2, and ApoC2 were significantly related to cognitive status. Moreover, ApoA1 and ApoA2 were independently associated with cognitive impairment and late-life dementia.

  3. Researchers use world&apos;s only direct calorimeter

    Energy Technology Data Exchange (ETDEWEB)

    Tollinsky, N.

    2008-09-15

    The world&apos;s only direct calorimeter is being used as part of a study to evaluate the risk of heat stress in miners working underground. The direct calorimeter measures the body&apos;s capacity for heat dissipation in specific environmental conditions. The body dissipates heat by increasing blood flow to the skin and transferring it to the environment. The surface of the skin is then cooled by airflow and sweat evaporation. While most studies examining the risks of heat stress are conducted using young, healthy males, the average age of most miners is 42, and many miners are obese or diabetic. Conditions such as diabetes can compromise the body&apos;s ability to cool itself. The calorimeter will also be used to measure the impact of different clothing options and materials on heat dissipation. The aim of the study was to ensure that adequate guidelines are developed to ensure the safety and comfort of miners. 1 fig.

  4. Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain.

    Science.gov (United States)

    Leishman, Emma; Mackie, Ken; Luquet, Serge; Bradshaw, Heather B

    2016-06-01

    A leading hypothesis of N-acyl ethanolamine (NAE) biosynthesis, including the endogenous cannabinoid anandamide (AEA), is that it depends on hydrolysis of N-acyl-phosphatidylethanolamines (NAPE) by a NAPE-specific phospholipase D (NAPE-PLD). Thus, deletion of NAPE-PLD should attenuate NAE levels. Previous analyses of two different NAPE-PLD knockout (KO) strains produced contradictory data on the importance of NAPE-PLD to AEA biosynthesis. Here, we examine this hypothesis with a strain of NAPE-PLD KO mice whose lipidome is uncharacterized. Using HPLC/MS/MS, over 70 lipids, including the AEA metabolite, N-arachidonoyl glycine (NAGly), the endocannabinoid 2-arachidonyl glycerol (2-AG) and prostaglandins (PGE(2) and PGF(2α)), and over 60 lipoamines were analyzed in 8 brain regions of KO and wild-type (WT) mice. Lipidomics analysis of this third NAPE-PLD KO strain shows a broad range of lipids that were differentially affected by lipid species and brain region. Importantly, all 6 NAEs measured were significantly reduced, though the magnitude of the effect varied by fatty acid saturation length and brain region. 2-AG levels were only impacted in the brainstem, where levels were significantly increased in KO mice. Correspondingly, levels of arachidonic acid were significantly decreased exclusively in brainstem. NAGly levels were significantly increased in 4 brain regions and levels of PGE(2) increased in 6 of 8 brain regions in KO mice. These data indicate that deletion of NAPE-PLD has far broader effects on the lipidome than previously recognized. Therefore, behavioral characteristics of suppressing NAPE-PLD activity may be due to a myriad of effects on lipids and not simply due to reduced AEA biosynthesis. PMID:26956082

  5. Promoting and Financing Cultural Tourism in Europe through European Capitals of Culture: A Case Study of Košice, European Capital of Culture 2013

    Directory of Open Access Journals (Sweden)

    Miriam Šebová

    2014-05-01

    Full Text Available The paper highlights the link between the European Capital of Culture (ECoC designation and the development of cultural tourism in Europe. Cultural tourism is the fastest growing segment of tourism in the world and is the desirable objective of new defined cultural policies in European cities. According to the European Commission (2012, it is estimated that cultural tourism accounts for around 40% of all European tourism. In general, the European Commission confirms the significant role of cultural tourism in the development of tourism in Europe and one of the most visible tools of this strategy is the designation of the ECoC. Cultural policy has also become an important tool of urban regeneration and in the rebranding of European cities. The case study of Košice ECoC 2013 presents part of the results from the Košice ECoC evaluation project. The Košice ECoC 2013 project was designed as a community led project which was targeted at increasing the cultural consumption of residents rather than the number of foreign cultural tourists. However, the biggest events such as White night attracted a lot of tourists from the wider region. More than 70 million EUR was dedicated to investments, which have significantly improved the culture infrastructure in Košice. The ECoC designation supported the local cultural buzz and led to new local production of modern culture, art and the creative industries. Other visible effects have already been seen in the advantages gained by the decentralization of the cultural infrastructure and events in the neighbourhoods. The involvement of people outside the city centre has avoided gentrification in the city. From this point of view the project Košice ECoC 2013 has had the prerequisite to sustainable cultural tourism in Košice

  6. Ausbildung zum Öko-Landwirt: Auswertung einer Podiumsdiskussion auf dem „1. Aktionstag Ökologischer Landbau“ in Mecklenburg-Vorpommern

    OpenAIRE

    Köppen, Detloff

    2002-01-01

    Die anspruchsvollen politischen Ziele für die Entwicklung des ökologischen Landbaus in der BRD können nur erreicht werden, wenn in den Öko-Betrieben aber auch in den Anbauverbänden und den Beratungseinrichtungen spezifisch für den ökologischen Landbau ausgebildetes und motiviertes Personal zur Verfügung steht. Dabei ist insbesondere die Kontinuität in der Betriebsentwicklung zu sichern. Für die spezifische Ausbildung zum Öko-Landwirt müssen auf allen Ausbildungsebenen die Rahmenbedingungen we...

  7. Gegužraibinių augalų populiacijų vertinimas Šveicarijos miško europinės svarbos buveinėse

    OpenAIRE

    Antonovas, Donatas

    2014-01-01

    Magistro darbe tiriamas gegužraibinių (Orchidaceae) šeimos augalų populiacijų gyvybingumas priklausomai nuo EB buveinių tvarkymo intensyvumo Šveicarijos miško BAST. Darbo objektas – Šveicarijos miško BAST gegužraibinių (Orchidaceae) augalų populiacijos. Darbo tikslas – įvertinti gegužraibinių (Orchidaceae) šeimos populiacijų gausumą skirtinguose tvarkymo plotuose, priklausomai nuo gamtotvarkos darbų reguliarumo. Darbo metodai – gegužraibinių (Orchidaceae) augalų individų apskaita. Darbo rezul...

  8. Irradiation as a quarantine treatment of &apos;Carabao&apos; (&apos;Manila Super&apos;) mangoes

    International Nuclear Information System (INIS)

    Researches using gamma radiation for disinfestation of Oriental fruit fly in &apos;Carabao&apos; (&apos;Manila Super&apos;) mangoes were undertaken using the Probit 9 or 99.9968% mortality test. The results showed that the mature larvae of the fruit fly are the most tolerant stage of this insect to irradiation with the eggs as the most sensitive. On treating more than 100,000 mature larvae in mangoes, a minimum dose of 100 Gy was found to prevent emergence of adult fruit flies and maintain quarantine security or a complete elimination of the possibility of introducing this pest into the importing country. Therefore, the use of 100-Gy irradiation as a quarantine treatment against Oriental fruit fly in the mature green Philippine &apos;carabao&apos; mango fruits is recommended

  9. Targeting the adolescent male.

    Science.gov (United States)

    Pitt, E

    1986-01-01

    The National Urban League regards too early parenting among adolescents as an issue requiring high level, active attention from all segments of the Black community. Poverty, single parent households and adolescent pregnancies are not exclusively female problems. The role that males play has been missing from too many studies of these phenomena. In light of the fact that most sexual activity is male initiated, and most sexual behavior is male influenced, it becomes clear that there will be no resolution of the problem of teenage pregnancy without directing greater attention to the male. The issue of male responsibility is skirted too often due to parental pride on the part of mothers and fathers when their male children seek sexual relations with female partners. It is viewed as a sign that they are developing sexually within the norm. This is especially true, in many instances, in female headed households where the mother is concerned that she may not be providing her son with an adequate male role model. Sexual activity by female adolescents, however, is generally not condoned. This confusing double standard is further compounded by the disjointed fashion in which American society responds to adolescent sexuality on the whole. Although the home should be the focal point, many parents reluctantly admit an inability to communicate effectively about sex with their pre-adolescent children. Thus, the school, church, community and social agencies have all been enlisted in this task. The National Urban League's initiative in this area is expected to have significant impact on the course of adolescent sexuality and reproductive responsibility.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:3745498

  10. Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer’s disease

    Directory of Open Access Journals (Sweden)

    Xu eHou

    2015-10-01

    Full Text Available Alzheimer’s disease (AD, the most common form of dementia, disproportionately affects women in both prevalence and severity. This increased vulnerability to AD in women is strongly associated with age-related ovarian hormone loss and apolipoprotein E 4 allele (ApoE4, the most important genetic risk factor for sporadic AD. Up to date, the mechanism involved in the interaction between ApoE4 and sex/gender in AD is still unclear. This study evaluated the sex-dependent ApoE4 effects on learning and memory, Aβ deposition and potential mechanisms, using mice bearing both sporadic (ApoE4 and familial (APPSwe, PS1M146V, tauP301L; 3xTg AD risk factors and compared with sex- and age-matched 3xTg or nonTg mice. Compared to nonTg mice, transgenic mice of both sexes showed spatial learning and memory deficits in the radial arm water maze and novel arm discrimination tests at 20 months of age. However, at 10 months, only ApoE4/3xTg mice showed significant learning and memory impairment. Moreover, molecular studies of hippocampal tissue revealed significantly higher protein levels of Aβ species, β-site APP cleavage enzyme (BACE1 and Sp1, a transcription factor of BACE1, in female ApoE4/3xTg when compared with female nonTg, female 3xTg and male ApoE4/3xTg mice. Significantly increased BACE1 enzymatic activities were observed in both male and female mice carrying ApoE4; however, only the females showed significant higher BACE1 expressions. Together, these data suggest that ApoE4 allele is associated with increased BACE1 enzymatic activity, while female sex plays an important role in increasing BACE1 expression. The combination of both provides a molecular basis for high Aβ pathology and the resultant hippocampus-dependent learning and memory deficits in female ApoE4 carriers.

  11. Male-male homosexology: seven short discourses.

    Science.gov (United States)

    Money, John

    2004-09-01

    Homosexology is that branch of the science of sexology that deals with same sex relationships. It is subdivided into ideation, imagery, and praxis. Praxeology is the science of praxis. There are two doctrines by which homosexuality is defined: elective and developmental. Elective is like joining a political party and is more likely bisexual than exclusively homosexual. Complete developmental homosexuality is a state of being and is characteristically immutable. Both types of homosexuality are determined multivariately and sequentially, not univariately. Male and female mammals are phylogenically programmed to be reciprocal, not identical, in the praxeology of their courtship and mating. In primate, notably human, evolution, the eyes have taken over from the nose as organs of erotic arousal, but the molecular biology of how this happens in individual development, gay, straight or ambivalent, remains to be ascertained. The different personal histories of homosexual development also remain to be ascertained and cataloged. PMID:15506674

  12. Tribološka svojstva kočnih papuča s povišenim udjelom fosfora

    OpenAIRE

    V. Marušić; Vitez, I.; Kladarić, I.

    2004-01-01

    Ispitivanje je provedeno u uvjetima suhog trenja sklizanja kladica izrađenih iz kočnih papuča po rotirajućem disku od istog materijala iz kojega se izrađuju i kotači vlakova. Analiziran je utjecaj kemijskog sastava, strukture i tvrdoće papuča na trošenje u simuliranim uvjetima ispitivanja kotač - papuča na tribološkom uređaju u laboratoriju. Utvrđeno je da otpornost trošenju papuča mnogo više ovisi o udjelu fosfora i strukturi nego o tvrdoći.

  13. Model organizacji koła naukowego a rozwój praktycznych kompetencji studentów

    OpenAIRE

    Kurzyk, Bartłomiej

    2015-01-01

    W artykule przedstawiono obserwacje autora oparte na prawie 15-letnim doświadczeniu w prowadzeniu organizacji naukowej studentów marketingu, SJN MarkeTEAM. Aktywny udział w pracach koła naukowego może mieć pozytywny wpływ na wiedzę i umiejętności uzyskiwane podczas studiów przez studentów. Aby jednak było to możliwe, organizacja musi być zarządzana w taki sposób, aby minimalizować ryzyko niepowodzenia projektów i w tym samym czasie stawiać przed studentami wyzwania, które pozwo...

  14. ŽENSKA PODOBA: PSIHOLOŠKO – SOCIOLOŠKA ANALIZA ŽENSKE PODOBE V TISKANIH MEDIJIH

    OpenAIRE

    Šlihthuber, Katja

    2013-01-01

    Diplomsko delo ŽENSKA PODOBA: psihološko – sociološka analiza podobe v tiskanih medijih zajema spoznanja o ženski podobi in njenem pojavljanju v tiskanih periodičnih medijih. Rdeča nit naloge je žensko telo in celostna podoba, pri čemer smo se dotaknili same definicije ženskega telesa in lepote s sociološkega vidika ter teoretična znanja navezali na prezentacijo ženske podobe v ženskih in moških revijah na slovenskem medijskem trgu. Teoretični del pojasnjuje odnose družbe do ženskega telesa i...

  15. Tragom njemačko-mađarsko-hrvatskih jezičnih dodira: problematika jezika posrednika

    OpenAIRE

    Puškar, Krunoslav

    2011-01-01

    U ovome radu autor daje kratak pregled njemačko-hrvatskih i mađarsko-hrvatskih jezičnih dodira s kontrastivnom analizom njemačkog i mađarskog utjecaja na hrvatski standardni i supstandardni sloj te njihova dosadašnja istraživanja. U ostatku rada težište se stavlja na ulogu i problematiku jezika posrednika kod istraživača jezičnih dodira i nekih leksikografskih djela na primjeru mađarskoga i dvadesetak posuđenica iz njemačkog jezika koje su mađarskim posredstvom posuđene u hrvatski jezik....

  16. Space characteristics of gamma-quantum families (&apos;'Pamir'&apos; experiment)

    Energy Technology Data Exchange (ETDEWEB)

    Bajburina, S.G.; Guseva, Z.M.; Denisova, V.G. (AN SSSR, Moscow. Fizicheskij Inst.)

    1980-01-01

    Relation of space and energy characteristics of gamma quanta families arising in the Earth atmosphere is discussed. It is shown that there is a tendency to the increase in the transverse size of gamma quanta families for families of gamma quanta of ..sigma..Esub(..gamma..)=200-400 TeV energy when enhancing multiplicity. Events of three-jet type were recorded. It is noted that a quasiscaling model doesn&apos;t permit to describe two-jet events as the result of fluctuations.

  17. Marketing manufactured housing under the &apos;&apos;Super Good Cents&apos;&apos; Program

    Energy Technology Data Exchange (ETDEWEB)

    Mohler, B.L.; Smith, S.A.

    1986-01-01

    The objective of this study is to propose a strategy for including manufactured housing (MH) in Bonneville Power Administration&apos;s Super Good Cents (SGC) Program. This report presents information on the site-built SGC program, the characterization of MH consumers, the options for including MH in the SGC program, and the recommendations for including MHs in the SGC program. The purposed strategy for including MHs in the SGC program is designed to reduce risks to manufacturers and dealers, stimulate demand, and allow for maximum flexibility.

  18. Genetically conditioned male sterility

    International Nuclear Information System (INIS)

    A survey is given of two different types of genetically controlled male sterility in higher plants. 'Functional' male sterility is due to the action of mutated genes causing a misdifferentiation of the growing points in different specific ways. Under the influence of the genes of this group either the stamens or the archespore tissues are not differentiated. In other mutants functionable male germ cells are produced but cannot be used for fertilizing the egg cells because the anthers remain closed or anthers and stigma become spatially separated from each other. Other genes of the group are responsible for the transformation of stamens into carpels, i.e. for a change of the hermaphrodite flower into a unisexually female one. A second type of male sterility is due to the action of ms genes influencing the course of micro-sporogenesis directly. They cause the breakdown of this process in a specific meiotic stage characteristic for each gene of the group. This breakdown is introduced by the degeneration of PMCs, microspores, or pollen grains preventing the production of male germ cells. The female sex organs remain uninfluenced. (author)

  19. &apos;&apos;Rueckbau 2014&apos;&apos;. KWS Congress regarding decommissioning and dismantling at Zwentendorf nuclear training power plant

    International Nuclear Information System (INIS)

    From September 24 to 25, 2014, KRAFTWERKS-SCHULE E.V. (KWS) held the congress &apos;&apos;Rueckbau 2014&apos;&apos;.This first congress about nuclear power plant decommissioning was combined with an exhibition in the fully equipped Zwentendorf nuclear training power plant. The exhibitors had the opportunity to present and test their products in the ambience of a real nuclear power plant, close to original plant components. The visitors got a general overview of the on-site conditions. During the lectures the process of decommissioning and dismantling of a nuclear power plant were described, problems within this process were discussed, and possible solutions were recommended.

  20. &apos;'Key'&apos; sectors in final energy consumption: an input-output application to the Spanish case

    Energy Technology Data Exchange (ETDEWEB)

    Alcantara, V.; Padilla, E. [Universitat Autonoma de Barcelona, Bellaterra (Spain). Dept. d' Economia Aplicada

    2003-12-01

    In this paper we analyze the determination of &apos;'key'&apos; sectors in the final energy consumption. We approach this issue from an input-output perspective and we design a methodology based on the elasticities of the demands of final energy consumption. As an exercise, we apply the proposed methodology to the Spanish economy. The analysis allows us to indicate the greater or lesser relevance of the different sectors in the consumption of final energy, pointing out which sectors deserve greater,attention in the Spanish case and showing the implications for energy policy. (author)

  1. Electrolyzed-water generator &apos;SaniBoy&apos;; Eisei jokinsuik kyokyu sochi &apos;SaniBoy&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Inoue, M.; Kakiuchi, H.; Muto, K. [Fuji Electric Co. Ltd., Tokyo (Japan)

    2000-03-10

    In the food industry, injuries due to food poisoning have been increasing. Especially the mass outbreak of food poisoning by Escherichia coli such as O-157 in 1996 gave warning on the importance of food sanitation management. Public efforts such as the Hazard Analysis and Critical Control Point (HACCP) system have been made to prevent food poisoning. Recently, disinfection made by electrolyzing water with some salt added has attracted attention. Fuji Electric has developed the generator &apos;SaniBoy&apos; that produces weak alkaline electrolyzed water without wasting water. The environment-friendly &apos;SaniBoy&apos; will contribute to sanitation in various fields. (author)

  2. Radiobiological study of the radioprotective activity of a natural Iranian compound, &apos;'Shir-Khecht'&apos;; Etude radiobiologique de l&apos;activite radioprotectrice d&apos;un compose naturel Iranien: le &apos;'Shir-Khecht'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Rouhanizadeh, N. [Commissariat a l' Energie Atomique, 92 - Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1968-01-01

    After reviewing the primary mechanisms of the action of ionizing radiation, the possible mechanisms of the action of radioprotective substances, the various chemical structures having a protective effect and the methods for studying chemical radioprotection, the author presents the results he has obtained with natural Iranian product: &apos;'Shir-Khecht'&apos;. Tests with this product at lethal and sublethal doses have been carried out on the rat using various means of introduction. The effect of radiation, both with and without protection, has been studied using histological and biochemical methods. The product examined has, in effect, a protective action; it is, furthermore, non-toxic and active when taken orally. (author) [French] Apres avoir rappele les mecanismes primaires de l&apos;action des rayonnements ionisants, les mecanismes possibles de l&apos;action des substances radioprotectrices, les diverses structures chimiques possedant un effet protecteur et les methodes d&apos;etude de la radioprotection chimique, l&apos;auteur presente les resultats qu&apos;il a obtenus en utilisant un compose naturel iranien: le &apos;'Shir-Khecht'&apos;. Des essais de ce produit, chez le rat, par diverses voies d&apos;introduction, a dose letale et subletale ont ete effectues. L&apos;effet des radiations, avec et sans protection, a ete etudie a l&apos;aide de methodes histologiques et biochimiques. Le compose essaye possede un pouvoir protecteur; il est, de plus, non toxique et actif par voie orale. (auteur)

  3. A tortoiseshell male cat

    DEFF Research Database (Denmark)

    Pedersen, A. S.; Berg, Lise Charlotte; Almstrup, Kristian;

    2014-01-01

    Tortoiseshell coat color is normally restricted to female cats due to X-linkage of the gene that encodes the orange coat color. Tortoiseshell male cats do, however, occur at a low frequency among tortoiseshell cats because of chromosome aberrations similar to the Klinefelter syndrome in man...... tissue from a tortoiseshell male cat referred to us. Chromosome analysis using RBA-banding consistently revealed a 39,XXY karyotype. Histological examinations of testis biopsies from this cat showed degeneration of the tubules, hyperplasia of the interstitial tissue, and complete loss of germ cells....... Immunostaining using anti-vimentin and anti-VASA (DDX4) showed that only Sertoli cells and no germ cells were observed in the testicular tubules. As no sign of spermatogenesis was detected, we conclude that this is a classic case of a sterile, male tortoiseshell cat with a 39,XXY chromosome complement. © 2013 S...

  4. Under-Threes&apos; Mathematical Learning--Teachers&apos; Perspectives

    Science.gov (United States)

    Franzén, Karin

    2014-01-01

    This project highlights preschool teachers&apos; views of toddlers&apos; learning in mathematics. The Swedish national curriculum covers even the youngest children who are 1-3?years old. Interesting questions are thus: what should mathematics be for this age group and how should preschool teachers work with maths to achieve the curriculum…

  5. Thermally activated (&apos;thermal&apos;) battery technology

    Energy Technology Data Exchange (ETDEWEB)

    Guidotti, Ronald A. [Sierra Nevada Consulting, 1536 W. High Pointe Ct., Minden, NV 89423 (United States); Masset, Patrick [Karl Winnacker Institut der DECHEMA e.V., Theodor-Heuss Allee 25, 60486 Frankurt am Main (Germany)

    2006-10-27

    Thermally activated (&apos;thermal&apos;) batteries are primary batteries that use molten salts as electrolytes and employ an internal pyrotechnic (heat) source to bring the battery stack to operating temperatures. They are primarily used for military applications, such as missiles and ordnance, and in nuclear weapons. This paper discusses the development history and presents a general overview of this technology. (author)

  6. Male infertility microsurgical training

    Institute of Scientific and Technical Information of China (English)

    Akanksha Mehta; Philip S Li

    2013-01-01

    Microsurgical training is imperative for urologists and clinical andrologists specializing in male infertility.Success in male infertility microsurgery is heavily dependent on the surgeon's microsurgical skills.Laboratory-based practice to enhance microsurgical skills improves the surgeon's confidence,and reduces stress and operating time,benefiting both the patient and the surgeon.This review provides guidelines for setting up a microsurgical laboratory to develop and enhance microsurgical skills using synthetic and animal models.The role of emerging techniques,such as robotic-assisted microsurgery,is also discussed.

  7. Comment on &apos;&apos;Teleportation of two-mode squeezed states&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    He Guangqiang; Zhang Jingtao [State Key Lab of Advanced Optical Communication Systems and Networks Department of Electronic Engineering, Shanghai Jiaotong University, Shanghai 200030 (China)

    2011-10-15

    We investigate the teleportation scheme of two-mode squeezed states proposed by Adhikari et al.[S. Adhikari et al., Phys. Rev. A 77, 012337 (2008)]. It uses four-mode entangled states to teleport two-mode squeezed states. The fidelity between the original two-mode squeezed states and teleported ones is calculated. The maximal fidelity value of Adhikari&apos;s protocol is 0.38, which is incompatible with the fidelity definition with the maximal value 1. In our opinion, one reason is that they calculate the fidelity for multimodes Gaussian states using the fidelity formula for single-mode ones. Another reason is that the covariance matrix of output states should be what is obtained after applying the linear unitary Bogoliubov operations (two cascaded Fourier transformations) on the covariance matrix given in Eq. (12) in their paper. These two reasons result in the incomparable results. In addition, Adhikari&apos;s protocol can be simplified to be easily implemented.

  8. Technology &apos;90

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    The US Department of Energy (DOE) laboratories have a long history of excellence in performing research and development in a number of areas, including the basic sciences, applied-energy technology, and weapons-related technology. Although technology transfer has always been an element of DOE and laboratory activities, it has received increasing emphasis in recent years as US industrial competitiveness has eroded and efforts have increased to better utilize the research and development resources the laboratories provide. This document, Technology &apos;90, is the latest in a series that is intended to communicate some of the many opportunities available for US industry and universities to work with the DOE and its laboratories in the vital activity of improving technology transfer to meet national needs. Technology &apos;90 is divided into three sections: Overview, Technologies, and Laboratories. The Overview section describes the activities and accomplishments of the DOE research and development program offices. The Technologies section provides descriptions of new technologies developed at the DOE laboratories. The Laboratories section presents information on the missions, programs, and facilities of each laboratory, along with a name and telephone number of a technology transfer contact for additional information. Separate papers were prepared for appropriate sections of this report.

  9. Expression of the human apoE2 isoform in adipocytes: altered cellular processing and impaired adipocyte lipogenesis

    OpenAIRE

    Huang, Zhi H.; Maeda, Nobuyo; Mazzone, Theodore

    2011-01-01

    Expression of apoE in adipocytes has been shown to have an important role in modulating adipocyte triglyceride (TG) metabolism and gene expression that is independent of circulating and extracellular apoE. The impact of adipocyte expression of common human apoE isoforms was evaluated using adipocytes harvested from human apoE2, -3, and -4 knock-in mice. Expression of the apoE2 isoform was associated with an increase in adipocyte apoE gene expression and apoE synthesis. Newly synthesized apoE2...

  10. &apos;Green Isle&apos; on the &apos;Red Isle&apos;. The gasometer in Berlin becomes a centre of the &apos;European Energy Forum&apos;; &apos;Gruene Insel&apos; auf der &apos;Roten Insel&apos;. Der Berliner Gasometer wird zum Zentrum des &apos;Europaeischen Energie Forums&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Ulf

    2013-06-01

    If the ARD political talk show with Guenther Jauch starts on Sunday night after the crime thriller, only few viewers know that they are tele-guests on the former gasometer site in Berlin-Schoeneberg. Currently, this site is being transformed into an environmentally friendly campus called the &apos;European Energy Forum&apos; (EUREF). According to the will of the owner and architect Reinhard Mueller, the campus will become the largest CO{sub 2} neutral office and business location in Europe. Totally 600 million Euro will be invested. All new buildings should be ecological &apos;green buildings&apos; and received the LEED Gold certification.

  11. HDL from apoA1 transgenic mice expressing the 4WF isoform is resistant to oxidative loss of function[S

    OpenAIRE

    Berisha, Stela Z.; Brubaker, Greg; Kasumov, Takhar; Hung, Kimberly T.; DiBello, Patricia M.; Huang, Ying; Li, Ling; Willard, Belinda; Pollard, Katherine A.; Nagy, Laura E; Hazen, Stanley L.; Smith, Jonathan D.

    2015-01-01

    HDL functions are impaired by myeloperoxidase (MPO), which selectively targets and oxidizes human apoA1. We previously found that the 4WF isoform of human apoA1, in which the four tryptophan residues are substituted with phenylalanine, is resistant to MPO-mediated loss of function. The purpose of this study was to generate 4WF apoA1 transgenic mice and compare functional properties of the 4WF and wild-type human apoA1 isoforms in vivo. Male mice had significantly higher plasma apoA1 levels th...

  12. EXPRESSION OF EGFR AND ITS LIGANDS IN RESPONSE TO TCDD OR RETINOIC ACID IN EGF AND TGFALPHA KO FETAL MOUSE PALATE

    Science.gov (United States)

    EXPRESSION OF EGFR AND ITS LIGANDS IN RESPONSE TO TCDD OR RETINOIC ACID IN EGF AND TGF" KO FETAL MOUSE PALATE. Abbott, Barbara D.1; Boyd, Hadiya2; Wood, Carmen1; Held, Gary1. 1.EPA, ORD, NHEERL, RTD, US EPA, Research Triangle Park, NC, USA. 2MARC Program, NCCU, Durham, NC, USA. <...

  13. Genome Sequence of Halomonas sp. Strain KO116, an Ionic Liquid-Tolerant Marine Bacterium Isolated from a Lignin-Enriched Seawater Microcosm

    OpenAIRE

    O’Dell, Kaela B.; Woo, Hannah L.; Utturkar, Sagar; Klingeman, Dawn; Brown, Steven D.; Hazen, Terry C

    2015-01-01

    Halomonas sp. strain KO116 was isolated from Nile Delta Mediterranean Sea surface water enriched with insoluble organosolv lignin. It was further screened for growth on alkali lignin minimal salts medium agar. The strain tolerates the ionic liquid 1-ethyl-3-methylimidazolium acetate. Its complete genome sequence is presented in this report.

  14. Interpretace je víc než interpretace. K reflexi hermeneutického pohybu u Zdeňka Kožmína

    Czech Academy of Sciences Publication Activity Database

    Kanda, Roman

    2015-01-01

    Roč. 2, č. 4 (2015), s. 20-25 Institutional support: RVO:68378068 Keywords : Kožmín, Zdeněk * hermeneutics * interpretation Subject RIV: AJ - Letters, Mass-media, Audiovision https ://issuu.com/pulsystudentskaliterarnirevue/docs/pulsy_4_issuu

  15. Gambogic acid induces mitochondria-dependent apoptosis by modulation of Bcl-2 and Bax in mantle cell lymphoma JeKo-1 cells

    Institute of Scientific and Technical Information of China (English)

    Jingyan Xu; Min Zhou; Jian Ouyang; Jing Wang; Qiguo Zhang; Yong Xu; Yueyi Xu

    2013-01-01

    Objective:To study the mechanisms in gambogic acid (GA)-induced JeKo-1 human Mantle Cell Lymphoma cell apoptosis in vitro.Methods:The proliferation of GA-treated JeKo-1 cells was measured by CCK-8 assay and Ki-67 immunocytochemical detection.Apoptosis,cell cycle and mitochondrial membrane potential were measured by flow cytometric analysis.Caspase-3,-8 and-9 were detected by colorimetric assay.Bcl-2 and Bax were analyzed by Western blotting.Results:GA inhibited cell growth in a time-and dose-dependent manner.GA induces apoptosis in JeKo-1 cells but not in normal bone marrow cells,which was involved in reducing the membrane potential of mitochondria,activating caspases-3,-8 and-9 and decreasing the ratio of Bcl-2 and Bax without cell cycle arresting.Conclusions:GA induced apoptosis in human MCL JeKo-1 cells by regulating Bcl-2/Bax and activating caspase-3,-8 and-9 via mitochondrial pathway without affecting cell cycle.

  16. Male mating biology

    Directory of Open Access Journals (Sweden)

    Howell Paul I

    2009-11-01

    Full Text Available Abstract Before sterile mass-reared mosquitoes are released in an attempt to control local populations, many facets of male mating biology need to be elucidated. Large knowledge gaps exist in how both sexes meet in space and time, the correlation of male size and mating success and in which arenas matings are successful. Previous failures in mosquito sterile insect technique (SIT projects have been linked to poor knowledge of local mating behaviours or the selection of deleterious phenotypes during colonisation and long-term mass rearing. Careful selection of mating characteristics must be combined with intensive field trials to ensure phenotypic characters are not antagonistic to longevity, dispersal, or mating behaviours in released males. Success has been achieved, even when colonised vectors were less competitive, due in part to extensive field trials to ensure mating compatibility and effective dispersal. The study of male mating biology in other dipterans has improved the success of operational SIT programmes. Contributing factors include inter-sexual selection, pheromone based attraction, the ability to detect alterations in local mating behaviours, and the effects of long-term colonisation on mating competitiveness. Although great strides have been made in other SIT programmes, this knowledge may not be germane to anophelines, and this has led to a recent increase in research in this area.

  17. Male breast cancer.

    Science.gov (United States)

    Ottini, Laura; Palli, Domenico; Rizzo, Sergio; Federico, Mario; Bazan, Viviana; Russo, Antonio

    2010-02-01

    Male breast cancer (MaleBC) is a rare disease, accounting for development; low-penetrance gene mutations (i.e. CHEK-2) are more common but involve a lower risk increase. About 90% of all male breast tumors have proved to be invasive ductal carcinomas, expressing high levels of hormone receptors with evident therapeutic returns. The most common clinical sign of BC onset in men is a painless palpable retroareolar lump, which should be evaluated by means of mammography, ultrasonography and core biopsy or fine needle aspiration (FNA). To date, there are no published data from prospective randomized trials supporting a specific therapeutic approach in MaleBC. Tumor size together with the number of axillary nodes involved are the main prognostic factors and should guide the treatment choice. Locoregional approaches include surgery and radiotherapy (RT), depending upon the initial clinical presentation. When systemic treatment (adjuvant, neoadjuvant and metastatic) is delivered, the choice between hormonal and or chemotherapy (CT) should depend upon the clinical and biological features, according to the FBC management guidelines. However great caution is required because of high rates of age-related comorbidities. PMID:19427229

  18. Eating Disordered Adolescent Males.

    Science.gov (United States)

    Eliot, Alexandra O.; Baker, Christina Wood

    2001-01-01

    Described a sample of eating disordered adolescent males who were seen for treatment at Boston Children's Hospital Outpatient Eating Disorders Clinic. Findings suggest the idea that clinicians, coaches, peers, and family should encourage young men to share concerns about body image and weight at an earlier, less severe juncture, with the assurance…

  19. &apos;&apos;Dural tail&apos;&apos; adjacent to acoustic neuroma on MRI: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Lunardi, P. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy)); Mastronardi, L. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy)); Nardacci, B. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy)); Acqui, M. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy)); Fortuna, A. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy))

    1993-04-01

    A &apos;dural tail&apos; on Gd-DTPA-enhanced MRI has been often observed adjacent to meningiomas and considered to be useful in distinguishing meningioma of the cerebellopontine angle from acoustic neuroma. However, demonstration of a dural tail adjacent to an acoustic neuroma indicates that this sign is not specific. (orig.)

  20. CONSTRAINING THE EVOLUTIONARY FATE OF CENTRAL COMPACT OBJECTS: &apos;'OLD'&apos; RADIO PULSARS IN SUPERNOVA REMNANTS

    International Nuclear Information System (INIS)

    Central compact objects (CCOs) constitute a population of radio-quiet, slowly spinning (≥100 ms) young neutron stars with anomalously high thermal X-ray luminosities. Their spin-down properties imply weak dipole magnetic fields (∼1010-11 G) and characteristic ages much greater than the ages of their host supernova remnants (SNRs). However, CCOs may posses strong &apos;'hidden'&apos; internal magnetic fields that may re-emerge on timescales of ≳10 kyr, with the neutron star possibly activating as a radio pulsar in the process. This suggests that the immediate descendants of CCOs may be masquerading as slowly spinning &apos;'old'&apos; radio pulsars. We present an X-ray survey of all ordinary radio pulsars within 6 kpc that are positionally coincident with Galactic SNRs in order to test the possible connection between the supposedly old but possibly very young pulsars and the SNRs. None of the targets exhibit anomalously high thermal X-ray luminosities, suggesting that they are genuine old ordinary pulsars unrelated to the superposed SNRs. This implies that CCOs are either latent radio pulsars that activate long after their SNRs dissipate or they remain permanently radio-quiet. The true descendants of CCOs remain at large

  1. Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender

    Directory of Open Access Journals (Sweden)

    Pereira Thiago MC

    2010-08-01

    Full Text Available Abstract Background Although advanced age is considered a risk factor for several diseases, the impact of gender on age-associated cardiovascular diseases, such as atherosclerotic processes and valvular diseases, remains not completely clarified. The present study was designed to assess aortic valve morphology and function and vascular damage in elderly using the apolipoprotein E knockout (ApoE KO mouse. Our hypothesis was that advanced age-related cardiovascular changes are aggravated in atherosclerotic male mice. Methods The grade (0 to 4 of aortic regurgitation was evaluated through angiography. In addition, vascular lipid deposition and senescence were evaluated through histochemical analyses in aged male and female ApoE KO mice, and the results were compared to wild-type C57BL/6J (C57 mice. Results Aortic regurgitation was observed in 92% of the male ApoE KO mice and 100% of the male C57 mice. Comparatively, in age-matched female ApoE KO and C57 mice, aortic regurgitation was observed in a proportion of 58% and 53%, respectively. Histological analysis of the aorta showed an outward (positive remodeling in ApoE KO mice (female: 1.86 ± 0.15; male: 1.89 ± 0.68 using C57 groups as reference values. Histochemical evaluation of the aorta showed lipid deposition and vascular senescence only in the ApoE KO group, which were more pronounced in male mice. Conclusion The data show that male gender contributes to the progression of aortic regurgitation and that hypercholesterolemia and male gender additively contribute to the occurrence of lipid deposition and vascular senescence in elderly mice.

  2. Improvement in remote sensing of low vegetation cover in arid regions by correcting vegetation indices for soil &apos;'noise'&apos;

    International Nuclear Information System (INIS)

    The variations of near-infrared red reflectance ratios of ten aridic soil samples were correlated with a &apos;&apos;redness index&apos;&apos; computed from red and green spectral bands. These variations have been shown to limit the performances of vegetation indices (NDVI and SAVI) in discriminating low vegetation covers. The redness index is used to adjust for this &apos;&apos;soil noise&apos;&apos;. Dala simulated for vegetation densities of 5 to 15% cover showed that the sensitivity of the corrected vegetation indices was significantly improved. Specifically, the &apos;'noise-corrected'&apos; SAVI was able to assess vegetation amounts with an error four times smaller than the uncorrected NDVI. These promising results should lead to a significant improvement in assessing biomass in arid lands from remotely sensed data. (author)

  3. In the Physics Class: University Physics Students&apos; Enactment of Class and Gender in the Context of Laboratory Work

    Science.gov (United States)

    Danielsson, Anna T.

    2014-01-01

    This article explores how the doing of social class and gender can intersect with the learning of science, through case studies of two male, working-class university students&apos; constitutions of identities as physics students. In doing so, I challenge the taken-for-granted notion that male physics students have an unproblematic relation to…

  4. General practitioners&apos; willingness to request plain lumbar spine radiographic examinations

    Energy Technology Data Exchange (ETDEWEB)

    Ryynaenen, Olli-Pekka E-mail: ollipekka.ryynanen@uku.fi; Lehtovirta, Jukka; Soimakallio, Seppo; Takala, Jorma

    2001-01-01

    Objectives: To examine general practitioners&apos; attitudes to plain lumbar spine radiographic examinations. Design: A postal questionnaire consisting of questions on background data and doctors&apos; opinions about plain lumbar spine radiographic examinations, as well as eight vignettes (imaginary patient cases) presenting indications for lumbar radiography, and five vignettes focusing on the doctors&apos; willingness to request lumbar radiography on the basis of patients&apos; age and duration of symptoms. The data were analysed according to the doctor&apos;s age, sex, workplace and the medical school of graduation. Setting: Finland. Subjects: Six hundred and fifteen randomly selected physicians working in primary health care (64% of original target group). Results: The vignettes revealed that the use of plain lumbar radiographic examination varied between 26 and 88%. Patient&apos;s age and radiation protection were the most prominent factors influencing doctors&apos; decisions to request lumbar radiographies. Only slight differences were observed between the attitudes of male and female doctors, as well as between young and older doctors. Doctors&apos; willingness to request lumbar radiographies increased with the patient&apos;s age in most vignettes. The duration of patients&apos; symptoms had a dramatic effect on the doctor&apos;s decision: in all vignettes, doctors were more likely to request lumbar radiography when patient&apos;s symptoms had exceeded 4 weeks. Conclusions: General practitioners commonly use plain lumbar spine radiographic examinations, despite its limited value in the diagnosis of low back pain. Further consensus and medical education is needed to clarify the indications for plain lumbar radiographic examination.

  5. Cerebral Hemorrhage and APOE genotype

    Institute of Scientific and Technical Information of China (English)

    Sun xiaojiang; Wu ping; Zhang jing; Lu shanqing; Li bing

    2000-01-01

    Background and Purpose: Current evidence Suggests that the apolipoprotein E (APOE)ε 4 allele predisposes to cerebral amyloid angiopathy (CAA) whereas ε 2 is associated with CAA-zelated hemorrhage. In this study we examined potential clinical risk factors inpatients with cerebral hemorrhage and assessed these with respect to APOE genotype. Methoeds: 146 patinas with cerebral hemorrhage and 70 normal controls were investigated. APOE genotypes were determined with use of polymerase Chain reaction techniques.Results: The frequency of allele gene ( 0.180 ) and the percentage of the APOE ε 4 genotype in the cerebral hemorrhage group were Significantly higher as compared with the e 4 prequency ( O.O72 ) in the control group respectively ( p=O.O389 ) .Conelusious: APOE ε 4 :allele is a risk gene for cerebral hemorrhage.

  6. Design Concept of a Seal-off Type 14 MeV Neutron Generator of 10&apos;&apos;1&apos;&apos;1n/s Range

    Energy Technology Data Exchange (ETDEWEB)

    In, S. R.; Oh, B. H. [KAERI, Daejeon (Korea, Republic of)

    2015-05-15

    The total neutron fluence during the life time is expected to be around 10MW·yr/m&apos;&apos;2 which may cause a damage of -100 dpa in materials. To estimate the adaptability of candidate materials in a few years, a 14MeV neutron source with a flux level of 3 - 5 x 10&apos;&apos;1&apos;&apos;8 n/s·m&apos;&apos;2, which is the goal of the IFMIF facility costing more than ¤1000M, is necessitated. The problem in making an intense neutron generator of beam target type is really not on the neutron production rate, but on the huge heat generated in the target, because the fusion power is only one of thousands of beam power exerted on the target. We have a plan to develop neutron generators step by step from a 10&apos;&apos;8 n/s level. The final goal is establishing a 14MeV neutron irradiation facility at 10&apos;&apos;1&apos;&apos;4 intensity level.. Up to the 10&apos;&apos;1&apos;&apos;0 n/s level, there occurs basically no critical thermal problem, because beam power density is in the range of tens W/cm&apos;&apos;2. The neutron generator designed in a sealed-off type because of tritium safety is mainly composed of an ion source, target, reaction chamber, and getter pump.. The major design concepts for the neutron generator with the neutron production rate of 10&apos;&apos;1&apos;&apos;1 n/s range were presented. The specifications of the ion source, target and getter have been determined for attaining the goal of the neutron generation rate.

  7. ApoE: In Vitro Studies of a Small Molecule Effector.

    Science.gov (United States)

    Mondal, Tridib; Wang, Hanliu; DeKoster, Gregory T; Baban, Berevan; Gross, Michael L; Frieden, Carl

    2016-05-10

    Apolipoprotein E4 (apoE4), one of three isoforms of apoE, is the major risk factor for developing late onset Alzheimer's disease. The only differences among these isoforms (apoE2, apoE3, and apoE4) are single amino acid changes. Yet these proteins are functionally very different. One approach to ameliorating the effect of apoE4 with respect to Alzheimer's disease would be to find small molecular weight compounds that affect the behavior of apoE4. Few studies of this approach have been carried out in part because there was no complete structure of any full-length apoE isoform until 2011. Here, we focus on one small molecular weight compound, EZ-482, and explore the effects of its binding to apoE. Using hydrogen-deuterium exchange, we determined that EZ-482 binds to the C-terminal domains of both apoE3 and apoE4. The binding to apoE4, however, is accompanied by a unique N-terminal allosteric effect. Using fluorescence methods, we determined an apparent dissociation constant of approximately 8 μM. Although EZ-482 binds to the C-terminal domain, it blocks heparin binding to the N-terminal domain. The residues of apoE that bind heparin are the same as those involved in apoE binding to LDL and LRP-1 receptors. The methods and the data presented here may serve as a template for future studies using small molecular weight compounds to modulate the behavior of apoE. PMID:27065061

  8. Early changes in vascular reactivity in response to 56Fe irradiation in ApoE-/- mice

    Science.gov (United States)

    White, C. Roger; Yu, Tao; Gupta, Kiran; Babitz, Stephen K.; Black, Leland L.; Kabarowski, Janusz H.; Kucik, Dennis F.

    2015-03-01

    Epidemiological studies have established that radiation from a number of terrestrial sources increases the risk of atherosclerosis. The accelerated heavy ions in the galacto-cosmic radiation (GCR) that astronauts will encounter on in space, however, interact very differently with tissues than most types of terrestrial radiation, so the health consequences of exposure on deep-space missions are not clear. We demonstrated earlier that 56Fe, an important component of cosmic radiation, accelerates atherosclerotic plaque development. In the present study, we examined an earlier, pro-atherogenic event that might be predictive of later atherosclerotic disease. Decreased endothelium-dependent vasodilation is a prominent manifestation of vascular dysfunction that is thought to predispose humans to the development of structural vascular changes that precede the development of atherosclerotic plaques. To test the effect of heavy-ion radiation on endothelium-dependent vasodilation, we used the same ApoE-/- mouse model in which we previously demonstrated the pro-atherogenic effect of 56Fe on plaque development. Ten week old male ApoE mice (an age at which there is little atherosclerotic plaque in the descending aorta) were exposed to 2.6 Gy 56Fe. The mice were then fed a normal diet and housed under standard conditions. At 4-5 weeks post-irradiation, aortic rings were isolated and endothelial-dependent relaxation was measured. Relaxation in response to acetylcholine was significantly impaired in irradiated mice compared to age-matched, un-irradiated mice. This decrease in vascular reactivity following 56Fe irradiation occurred eight weeks prior to the development of statistically significant exacerbation of aortic plaque formation and may contribute to the formation of later atherosclerotic lesions.

  9. EUGRIS: &apos;&apos;European Substainable Land and Groundwater Management Information System&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Frauenstein, J. [Federal Environmental Agency (UBA), Berlin (Germany)

    2003-07-01

    The presentation outlines and Accompanying Measure with the FP 5 to develop an web based EUropean Sustainable Land and GRoundwater Management Information System information system (EUGRIS). The management of contaminated land and groundwater requires an interdisciplinary approach and a considerable amount of supporting technical information and knowledge. EUGRIS will provide a generally available comprehensive and overarching information and innovation resource, to support both research and practical contaminated land and groundwater management. EUGRI is a gateway to provide a &apos;one stop shop&apos; for information provided by research projects, legislation, standards, best practice and other technical guidance and policy/regulatory publications from the EC, participating Member and Accession States and from various international networks dealing with groundwater and land management issues. Different types of user can access information through different windows according to their needs. EUGRIS will provide its visitors with summary information (digests) and links to sources of more detailed and/or original information in a scaleable holistic and contexturally meaningful way. EUGRIS is being built in three stages: the design of the information system, the development of its software implementation, and the population of the system with information. The presentation is focussed on the concept of the development of the information system with the individual work packages. In the second part of the lecture in particular the work procedures are presented for the content wise replenishment by EUGRIS. The data collation for the proven pilot countries and the production of a European research data base, which opens contents and results of European-wide locked and current projects, form the emphasis thereby. (orig.)

  10. Stratospheric sulfate from the Gareloi eruption, 1980: Contribution to the &apos;'ambient'&apos; aerosol by a poorly documented volcanic eruption

    Energy Technology Data Exchange (ETDEWEB)

    Sedlacek, W.A.; Mroz, E.J.; Heiken, G.

    1981-07-01

    While sampling stratospheric aerosols during July--August 1980 a plume of &apos;'fresh'&apos; volcanic debris was observed in the Northern hemisphere. The origin of this material seems to be a poorly documented explosive eruption of Gareloi valcano in the Aleutian Islands. The debris was sampled at an altitude of 19.2 km: almost twice the height of observed eruption clouds. Such remote, unobserved or poorly documented eruptions may be a source that helps maintain the &apos;'ambient'&apos; stratospheric aerosol background.

  11. Vertiefungskurs 2014. Safety margins in nuclear power plants. Identify, quantify and extend; Vertiefungskurs 2014 zum Thema &apos;&apos;Sicherheitsmargen in Kernkraftwerken. Identifizieren, quantifizieren, erweitern&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Rey, Matthias

    2015-02-15

    Fifteen speakers dealt with the topic safety margins in nuclear power plants from different points of view at the &apos;&apos;Vertiefungskurs 2014&apos;&apos; of the Nuklearforum Schweiz in Olten, 4 and 5 November 2014. In the context of the &apos;&apos;Vertiefungskurs 2014&apos;&apos; the safety margins in power plants were considered and quantified and possible extensions have been discussed. The conference started with an in-depth introduction of the basis design of existing nuclear power plants. Thereafter speakers told about the main topics emergency preparedness, knowledge management and safety retrofit of nuclear power plants in operation.

  12. Craniofacial norms in white adult males. Final report 1 Oct 80-30 Sep 83

    Energy Technology Data Exchange (ETDEWEB)

    Kapur, K.K.; Lestrel, P.

    1983-01-01

    The objective of this investigation was to establish clinical &apos;norms&apos; of craniofacial skeletal orientation and the associated soft tissue facial profile for adult white males. Lateral and frontal cephalometric radiographs and study casts taken on 305 white males, with 28 or more teeth and 25-75 years of age, were used to develop these craniofacial standards. The goal of the research program has been to develop a computerized approach based upon dentofacial templates for the fabrication of complete dentures and to define clinical standards that can be applied in assessing the prosthodontic and orthodontic treatment needs of adult patients.

  13. Male genital lichen sclerosus.

    Science.gov (United States)

    Bunker, Christopher Barry; Shim, Tang Ngee

    2015-01-01

    Male genital lichen sclerosus (MGLSc) is a chronic inflammatory skin disease responsible for male sexual dyspareunia and urological morbidity. An afeared complication is squamous cell carcinoma (SCC) of the penis. The precise etiopathogenesis of MGLSc remains controversial although genetic, autoimmune and infective (such as human papillomavirus (HPV) hepatitis C (HCV), Epstein-Barr virus (EBV) and Borrelia) factors have been implicated: Consideration of all the evidence suggests that chronic exposure of susceptible epithelium to urinary occlusion by the foreskin seems the most likely pathomechanism. The mainstay of treatment is topical ultrapotent corticosteroid therapy. Surgery is indicated for cases unresponsive to topical corticosteroid therapy, phimosis, meatal stenosis, urethral stricture, carcinoma in situ (CIS) and squamous cell carcinoma. PMID:25814697

  14. Male genital lichen sclerosus

    Directory of Open Access Journals (Sweden)

    Christopher Barry Bunker

    2015-01-01

    Full Text Available Male genital lichen sclerosus (MGLSc is a chronic inflammatory skin disease responsible for male sexual dyspareunia and urological morbidity. An afeared complication is squamous cell carcinoma (SCC of the penis. The precise etiopathogenesis of MGLSc remains controversial although genetic, autoimmune and infective (such as human papillomavirus (HPV hepatitis C (HCV, Epstein-Barr virus (EBV and Borrelia factors have been implicated: Consideration of all the evidence suggests that chronic exposure of susceptible epithelium to urinary occlusion by the foreskin seems the most likely pathomechanism. The mainstay of treatment is topical ultrapotent corticosteroid therapy. Surgery is indicated for cases unresponsive to topical corticosteroid therapy, phimosis, meatal stenosis, urethral stricture, carcinoma in situ (CIS and squamous cell carcinoma.

  15. Male Gender Role Dysfunction

    OpenAIRE

    Daig, Isolde

    2010-01-01

    Background: Men have a higher alcohol and cigarette consumption than women, they use more drugs, they have twice as high a suicide rate and only a minority of men attend on preventive medical checkups. Hypotheses: The central questions of the present study pertained to the identification of dysfunctional aspects of a male self concept and the possible correlations with risk behaviour of men in different age stages. One possible explanation for this high risk behaviour may be higher mascul...

  16. Documentation to the workshop &apos;Cluster in the environmental protection economy&apos;; Dokumentation zum Workshop &apos;&apos;Cluster in der Umweltschutzwirtschaft&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-12-11

    Within the workshop &apos;Cluster in the environmental protection economy&apos; at the Umweltbundesamt (Dessau-Rosslau, Federal Republic of Germany) at 27th November, 2008, the following lectures were held: (a) Which contribution can cluster and cluster politics contribute to the promotion of the environmental protection economy? (Harald Legler); (b) Cluster in the environmental protection economy: Targets and expectations (Dieter Rehfeld); (c) Demands at the management of clusters (Karin Hoerhan); (d) Demands at the cluster politics in the environmental protection economy (Bernhard Hausberg); (e) Photovoltaics in Eastern Germany (Johann Wackenbauer); (f) Automotive industry in Bergisches Land (Thomas Lemken); (g) Competence centre environment Augsburg-Schwaben (Egon Beckord).

  17. Magnetooptical measurements of {beta}&apos;&apos;-(BEDT-TTF)(TCNQ)

    Energy Technology Data Exchange (ETDEWEB)

    Kimata, M.; Oshima, Y.; Ohta, H.; Koyama, K.; Motokawa, M.; Yamamoto, H.M.; Kato, R

    2004-04-30

    Magnetooptical measurements have been performed on {beta}&apos;&apos;-(BEDT-TTF)(TCNQ) using the cavity perturbation techniques. {beta}&apos;&apos;-(BEDT-TTF)(TCNQ) has very exotic Fermi surface (FS). Several harmonic resonances were observed at various angles. We consider these resonances as q1D-periodic orbit resonance. The obtained Fermi velocity and the scattering time are 4.4x10{sup 4} m/s and 2.1x10{sup -11} s, respectively. When the magnetic field was rotated in the b{sup *}a-plane, the similar resonances are observed. According to these results, the FS topology of the system at low temperature is discussed.

  18. SOLAR MAGNETIZED &apos;TORNADOES&apos;: RELATION TO FILAMENTS

    Energy Technology Data Exchange (ETDEWEB)

    Su Yang; Veronig, Astrid; Temmer, Manuela [IGAM-Kanzelhoehe Observatory, Institute of Physics, University of Graz, Universitaetsplatz 5, A-8010 Graz (Austria); Wang Tongjiang [Department of Physics, Catholic University of America, Washington, DC 20064 (United States); Gan Weiqun, E-mail: yang.su@uni-graz.at [Key Laboratory of Dark Matter and Space Astronomy, Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008 (China)

    2012-09-10

    Solar magnetized &apos;tornadoes&apos;, a phenomenon discovered in the solar atmosphere, appear as tornado-like structures in the corona but are rooted in the photosphere. Like other solar phenomena, solar tornadoes are a feature of magnetized plasma and therefore differ distinctly from terrestrial tornadoes. Here we report the first analysis of solar &apos;tornadoes&apos; (two papers which focused on different aspects of solar tornadoes were published in the Astrophysical Journal Letters and Nature, respectively, during the revision of this Letter). A detailed case study of two events indicates that they are rotating vertical magnetic structures probably driven by underlying vortex flows in the photosphere. They usually exist as a group and are related to filaments/prominences, another important solar phenomenon whose formation and eruption are still mysteries. Solar tornadoes may play a distinct role in the supply of mass and twists to filaments. These findings could lead to a new explanation of filament formation and eruption.

  19. Quarks: Two&apos;s company, three a crowd?

    International Nuclear Information System (INIS)

    Last year, careful measurements by the experiments studying electron positron annihilation in CERN&apos;s new LEP ring and at Stanford&apos;s SLC linear collider showed that the conventional list of the basic constituents of matter is complete. Three types of particles (electron, muon and tau) interacting under the weak nuclear force are linked to six quarks - the constituents of nuclear matter - grouped pairwise into three distinct families (&apos;up&apos; and &apos;down&apos;, &apos;strange&apos; and &apos;charm&apos;, &apos;beauty&apos; and &apos;top&apos;). The question now is to understand why this sixquark model works

  20. Characterisation of epeiric &apos;'layer-cake'&apos; carbonate reservoirs: Upper Muschelkalk (Middle Triassic), the Netherlands

    Energy Technology Data Exchange (ETDEWEB)

    Borkhataria, R.; Aigner, T.; Poeppelreiter, M.C.; Pipping, J.C.P. [Shell International Exploration and Production Inc., Houston, TX (United States)

    2005-04-01

    Upper Muschelkalk (Middle Triassic) carbonates produce natural gas at Coevorden field in the NE Netherlands. This is currently the only field that produces gas from this succession although several other prospects have been identified nearby. In order to help develop these hydrocarbons, this study proposes a facies and reservoir model of the Upper Muschelkalk in the NE Netherlands together with a regional framework intended to assist in further evaluation. Distribution of facies and reservoir properties of the Upper Muschelkalk carbonates in the NE Netherlands indicate deposition on a storm-dominated epeiric ramp with a very low gradient. The predominantly muddy and marly lithofacies types in proximal and distal parts of the ramp gradually interfinger with a shoreline-detached &apos;'shoal'&apos;-like ooidal grainstone complex. The best reservoir quality (permeability up to 60 mD) is recognised within dolomitised peloid ooid grainstones. These are interpreted as high-energy backshoal deposits. Reservoir quality decreases in the limestone-dominated &apos;'shoal'&apos; facies and the muddier foreshoal facies. A four-fold hierarchy of depositional cycles describes the systematic and thus predictable vertical variation in reservoir quality (permeability) and quantity (net-to-gross). High-resolution correlation suggests that medium-scale cycles (5 to 15 metres thick) can be traced for hundreds of kilometres. Small-scale cycles (1 to 3 metres thick) are persistent for several tens of kilometres and have sheet-like geometries. Individual reservoir units (several decimetres thick) appear to be laterally continuous over a maximum of a few kilometres although internal flow barriers might be expected. Mapping of Upper Muschelkalk thickness and facies has clearly defined backshoal, &apos;'shoal'&apos; and foreshoal facies belts with distinctly different reservoir characteristics. Typically, reservoir quality and quantity decrease with increasing

  1. Addendum to &apos;&apos;Scattering of twisted particles: Extension to wave packets and orbital helicity&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Ivanov, I. P. [IFPA, Universite de Liege, Allee du 6 Aout 17, Batiment B5a, 4000 Liege (Belgium); Sobolev Institute of Mathematics, Koptyug Avenue 4, 630090, Novosibirsk (Russian Federation); Serbo, V. G. [Sobolev Institute of Mathematics, Koptyug Avenue 4, 630090, Novosibirsk (Russian Federation); Novosibirsk State University, Pirogova Street 2, 630090, Novosibirsk (Russian Federation)

    2011-12-15

    In a recent work [Phys. Rev. A 84, 033804 (2011)] we considered elastic scattering of a twisted particle from a plane wave and studied how the orbital helicity of the twisted particle changes after scattering. We showed that for realistic beams the relative change can be small, |m{sup &apos;}-m|/m<<1, thus resolving a controversy which existed in the literature. In this Addendum, using a more accurate analysis, we argue that in the kinematics of Compton backscattering a stronger statement is true: in fact m{sup &apos;}{approx_equal}m, and the difference |m{sup &apos;}-m| even by a single unit is already suppressed.

  2. Swiss &apos;Electricity&apos; Research Programme 2004-2007; Konzept des Forschungsprogramms &apos;Elektrizitaet&apos; 2004 - 2007

    Energy Technology Data Exchange (ETDEWEB)

    Brueniger, R.

    2004-07-01

    This report issued by the Swiss Federal Office of Energy (SFOE) provides details on Swiss research in the electricity area that is foreseen for the period 2004-2007. The report discusses the current state of electricity research and the strategic goals for the period and presents the organisations involved and their previous work. The general main areas of interest addressed by the programme are noted, such as the storage and transport of electricity as well as its use in communication technologies, motors, domestic appliances and industrial applications. Figures are presented on the programme&apos;s finances and the concept of &apos;trend-watching&apos; groups is briefly addressed.

  3. MRI findings in von Recklinghausen&apos;s disease with extensive neurofibromatosis. Kernspintomographische Befunde beim M. von Recklinghausen mit ausgedehnten Neurofibromen

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, R. (Gemeinnuetziges Gemeinschaftskrankenhaus, Klinikum der Universitaet Witten-Herdecke, Herdecke (Germany). Inst. fuer Kernspintomographie)

    1991-07-01

    A male patient was examined by nuclear spin tomography. He was found to have Recklinghausen&apos;s disease, with multiple tumours whose histopathological picture showed them to be of the neurofibroma type. (GDG).

  4. Flavonoid biosynthesis: &apos;new&apos; functions for an &apos;old&apos; pathway

    International Nuclear Information System (INIS)

    Flavonoids are important plant secondary metabolites that have been extensively studied using genetic, biochemical and molecular approaches. Recent analyses have focused on our understanding of the role of flavonoids in such well-established processes as plant-microbe interactions and protection against ultraviolet (UV) light, and have also uncovered a previously unsuspected role in male fertility. These studies demonstrate the utility of flavonoid structures for a broad range of activities, and also highlight the value of the flavonoid pathway as a paradigm for studying the evolution of plant metabolism

  5. Folate targeted polymeric &apos;green&apos; nanotherapy for cancer

    Energy Technology Data Exchange (ETDEWEB)

    Narayanan, Sreeja; Binulal, N S; Mony, Ullas; Manzoor, Koyakutty; Nair, Shantikumar; Menon, Deepthy, E-mail: deepthymenon@aims.amrita.edu [Amrita Center for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi-682 041, Kerala (India)

    2010-07-16

    The concept of &apos;green&apos; chemotherapy by employing targeted nanoparticle mediated delivery to enhance the efficacy of phytomedicines is reported. Poly (lactide-co-glycolide) (PLGA) nanoparticles encapsulating a well known nutraceutical namely, grape seed extract (GSE)-&apos;NanoGSE&apos;-was prepared by a nanoprecipitation technique. The drug-loaded nanoparticles of size {approx} 100 nm exhibited high colloidal stability at physiological pH. Molecular receptor targeting of this nanophytomedicine against folate receptor over-expressing cancers was demonstrated in vitro by conjugation with a potential cancer targeting ligand, folic acid (FA). Fluorescence microscopy and flow cytometry data showed highly specific cellular uptake of FA conjugated NanoGSE on folate receptor positive cancer cells. Studies were also conducted to investigate the efficiency of targeted (FA conjugated) versus non-targeted (non-FA conjugated) nanoformulations in causing cancer cell death. The IC{sub 50} values were lowered by a factor of {approx} 3 for FA-NanoGSE compared to the free drug, indicating substantially enhanced bioavailability to the tumor cells, sparing the normal ones. Receptor targeting of FA-NanoGSE resulted in a significant increase in apoptotic index, which was also quantified by flow cytometry and fluorescence microscopy. This in vitro study provides a basis for the use of nanoparticle mediated delivery of anticancer nutraceuticals to enhance bioavailability and effectively target cancer by a &apos;green&apos; approach.

  6. Quantitative phosphoproteomics of murine Fmr1-KO cell lines provides new insights into FMRP-dependent signal transduction mechanisms.

    Science.gov (United States)

    Matic, Katarina; Eninger, Timo; Bardoni, Barbara; Davidovic, Laetitia; Macek, Boris

    2014-10-01

    Fragile X mental retardation protein (FMRP) is an RNA-binding protein that has a major effect on neuronal protein synthesis. Transcriptional silencing of the FMR1 gene leads to loss of FMRP and development of Fragile X syndrome (FXS), the most common known hereditary cause of intellectual impairment and autism. Here we utilize SILAC-based quantitative phosphoproteomics to analyze murine FMR1(-) and FMR1(+) fibroblastic cell lines derived from FMR1-KO embryos to identify proteins and phosphorylation sites dysregulated as a consequence of FMRP loss. We quantify FMRP-related changes in the levels of 5,023 proteins and 6,133 phosphorylation events and map them onto major signal transduction pathways. Our study confirms global downregulation of the MAPK/ERK pathway and decrease in phosphorylation level of ERK1/2 in the absence of FMRP, which is connected to attenuation of long-term potentiation. We detect differential expression of several key proteins from the p53 pathway, pointing to the involvement of p53 signaling in dysregulated cell cycle control in FXS. Finally, we detect differential expression and phosphorylation of proteins involved in pre-mRNA processing and nuclear transport, as well as Wnt and calcium signaling, such as PLC, PKC, NFAT, and cPLA2. We postulate that calcium homeostasis is likely affected in molecular pathogenesis of FXS. PMID:25168779

  7. Intelligent OkiKoSenPBX1 Security Patrol Robot via Network and Map-Based Route Planning

    Directory of Open Access Journals (Sweden)

    Mbaïtiga Zacharie

    2009-01-01

    Full Text Available Problem statement: With an increased demand for security and limited numbers of trained security personnel, some security mangers have a lot of ground to police and limited staff to cover it. To compensate for shortages of security staff and to reduce the stress of security managers, we have developed an intelligent patrol robot system called "OkiKoSenPBX1". The system integrates a variety of sensors to gather environmental information and to detect abnormal events including intruders. Approach: In our approach, the route planning procedure was based on determining a sequence of intermediary goal points or coordinates x and y composing the robot trajectory. Results: A qualitative running experimental evaluation had been performed on the 1st floor of the Okinawa national college of technology as a preliminary practical implementation and its real-time performance was excellent, where a student like-guard can take control of the camera pan and tilt functions remotely. Conclusion: The real-time performance of the developed system that can leave security personnel hands-free for other important tasks is an irresistible system that can be put into practical use in a public offices facility, manufacturing facilities and various construction sites-everywhere there’s a need for advanced frontline security.

  8. Investigation into the In-box LOCA consequence and structural integrity of the KO HCCR TBM in an ITER

    International Nuclear Information System (INIS)

    Korea has developed a Helium Cooled Ceramic Reflector (HCCR) based Test Blanket System (TBS) for an ITER. Using the current TBM System (TBS) design, accident analyses were performed on eight selected reference accidents. Among them, the in-box LOCA is introduced in the present paper. This accident starts with a rupture of the cooling plates in the Breeding Zone (BZ) pressurizing the BZ box structure, and thus the subsequent pressurization of the Tritium Extraction System (TES). In this paper, the consequences of an accident such as pressurization in the BZ and the integrity of the internal structure of the TBM by this pressurization were investigated using a safety analysis code (GAMMA-FR) and a commercial code, ANSYS, respectively. The accident sequence and internal integrity of the KO HCCR TBS in the case of in-box LOCA were investigated using the developed GAMMA-FR code and commercial FEM code. TES pressurization may cause TBM outer box pressurization with a short time. However, the TBM outer box seems able to endure this pressure

  9. Deep-sea drilling. Practical aspects of 4D seismic: what an engineer needs to know. Developments in Iran: &apos;SIRRI&apos; of the Total company and &apos;DOROOD&apos; of the Elf company. The &apos;DOROOD&apos; operating plan. The &apos;SIRRI&apos; operating plan; Le forage en eau profonde. Aspects pratiques de la sismique 4D: ce qu&apos;un ingenieur doit savoir. Developpements en Iran: &apos;SIRRI&apos; de Total et &apos;DOROOD&apos; d&apos;Elf. Le projet &apos;DOROOD&apos;. Le projet &apos;SIRRI&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Claverie, P. [Schlumberger Sedco Forex, 92 - Montrouge (France); Bauquis, P.R. [Association Francaise des Techniciens et Professionnels du Petrole, AFTP, 92 - Paris-la-Defense (France); Seiller, B.; Geronimi, X. [Elf France, (France); Barthe, D. [Total Fina, 92 - La Defense (France)

    1999-08-01

    In this &apos;Drilling-Production&apos; section, in which 7 papers are gathered, 3 main topics are developed: (1)the deep-sea drilling (2)the practical aspects of 4D seismic (3)the &apos;SIRRI&apos; and &apos;DOROOD&apos; operating plans in Iran. Concerning the first point, it can be noticed that nowadays, mobile platforms are located in great offshore where water depths are of about 2400 m. In the second point is particularly detailed what 4D is, what it can do, what the primary conditions for it works are and how it costs. The third point is the more particularly detailed in this section (15 pages). At first an introduction indicates why Iran has to call to international petroleum investors, what the current problems of Iran are, what Iran has to do to attract foreign investment and technology and what the challenges to foreign companies are. Then the two operating plans: &apos;SIRRI&apos; and &apos;DOROOD&apos; are exposed into details. A synthesis of these plans, called of &apos;Buy Back&apos;, (production, investment, refund) is given as well as their advantages and disadvantages. (O.M.)

  10. HDL from apoA1 transgenic mice expressing the 4WF isoform is resistant to oxidative loss of function.

    Science.gov (United States)

    Berisha, Stela Z; Brubaker, Greg; Kasumov, Takhar; Hung, Kimberly T; DiBello, Patricia M; Huang, Ying; Li, Ling; Willard, Belinda; Pollard, Katherine A; Nagy, Laura E; Hazen, Stanley L; Smith, Jonathan D

    2015-03-01

    HDL functions are impaired by myeloperoxidase (MPO), which selectively targets and oxidizes human apoA1. We previously found that the 4WF isoform of human apoA1, in which the four tryptophan residues are substituted with phenylalanine, is resistant to MPO-mediated loss of function. The purpose of this study was to generate 4WF apoA1 transgenic mice and compare functional properties of the 4WF and wild-type human apoA1 isoforms in vivo. Male mice had significantly higher plasma apoA1 levels than females for both isoforms of human apoA1, attributed to different production rates. With matched plasma apoA1 levels, 4WF transgenics had a trend for slightly less HDL-cholesterol versus human apoA1 transgenics. While 4WF transgenics had 31% less reverse cholesterol transport (RCT) to the plasma compartment, equivalent RCT to the liver and feces was observed. Plasma from both strains had similar ability to accept cholesterol and facilitate ex vivo cholesterol efflux from macrophages. Furthermore, we observed that 4WF transgenic HDL was partially (∼50%) protected from MPO-mediated loss of function while human apoA1 transgenic HDL lost all ABCA1-dependent cholesterol acceptor activity. In conclusion, the structure and function of HDL from 4WF transgenic mice was not different than HDL derived from human apoA1 transgenic mice. PMID:25561462

  11. Prospects for neutron star equation of state constraints using &apos;'recycled'&apos; millisecond pulsars

    Energy Technology Data Exchange (ETDEWEB)

    Bogdanov, Slavko [Columbia University, Columbia Astrophysics Laboratory, New York, NY (United States)

    2016-02-15

    &apos;'Recycled'&apos; millisecond pulsars are a variety of rapidly spinning neutron stars that typically show thermal X-ray radiation due to the heated surface of their magnetic polar caps. Detailed numerical modeling of the rotation-induced thermal X-ray pulsations observed from recycled millisecond pulsars, including all relevant relativistic and stellar atmospheric effects, has been identified as a promising approach towards an astrophysical determination of the true neutron star mass-radius relation, and by extension the state of cold matter at densities exceeding those of atomic nuclei. Herein, I review the basic model and methodology commonly used to extract information regarding neutron star structure from the pulsed X-ray radiation observed from millisecond pulsars. I also summarize the results of past X-ray observations of these objects and the prospects for precision neutron star mass-radius measurements with the upcoming Neutron Star Interior Composition Explorer (NICER) X-ray timing mission. (orig.)

  12. &apos;&apos;Rueckbau 2014&apos;&apos;. KWS congress regarding decommissioning and dismantling at nuclear training power plant Zwentendorf

    International Nuclear Information System (INIS)

    From September 24th to 25th, 2014 the KRAFTWERKSSCHULE E.V. (KWS) held the congress &apos;&apos;Rueckbau 2014&apos;&apos;. This first congress about the deconstruction of nuclear power plants was combined with an exhibition in the fully equipped nuclear training power plant Zwentendorf. The exhibitors had the opportunity to present and test their products in the ambience of a real nuclear power plant, close to original plant components. The visitors got a general overview of the on-site conditions. During the lectures the process of decommissioning and dismantling of a nuclear power plant was described, problems within this process were discussed, and possible solutions were recommended. The congress influenced significantly the dialogue of all parties involved and contributed to an extensive exchange of knowledge and experience.

  13. The current status of &apos;&apos;Troitsk nu-mass&apos;&apos; experiment in search for sterile neutrino

    International Nuclear Information System (INIS)

    We propose a new experiment to search for a sterile neutrino in a few keV mass range at the &apos;&apos;Troitsk nu-mass&apos;&apos; facility. The expected signature corresponds to a kink in the electron energy spectrum in tritium beta-decay. The new goal compared to our previous experiment will be precision spectrum measurements well below end point. The experimental installation consists of a windowless gaseous tritium source and a high resolution electromagnetic spectrometer. We estimate that the current bounds on the sterile neutrino mixing parameter can be improved by an order of magnitude in the mass range under 5 keV without major upgrade of the existing equipment. Upgrades of calibration, data acquisition and high voltage systems will allow to improve the bounds by another order of magnitude

  14. Prospects for neutron star equation of state constraints using &apos;'recycled'&apos; millisecond pulsars

    International Nuclear Information System (INIS)

    &apos;'Recycled'&apos; millisecond pulsars are a variety of rapidly spinning neutron stars that typically show thermal X-ray radiation due to the heated surface of their magnetic polar caps. Detailed numerical modeling of the rotation-induced thermal X-ray pulsations observed from recycled millisecond pulsars, including all relevant relativistic and stellar atmospheric effects, has been identified as a promising approach towards an astrophysical determination of the true neutron star mass-radius relation, and by extension the state of cold matter at densities exceeding those of atomic nuclei. Herein, I review the basic model and methodology commonly used to extract information regarding neutron star structure from the pulsed X-ray radiation observed from millisecond pulsars. I also summarize the results of past X-ray observations of these objects and the prospects for precision neutron star mass-radius measurements with the upcoming Neutron Star Interior Composition Explorer (NICER) X-ray timing mission. (orig.)

  15. Computerized axial tomography of the chest for visualization of &apos;'absent'&apos; pulmonary arteries

    Energy Technology Data Exchange (ETDEWEB)

    Sondheimer, H.M. (Upstate Medical Center, Syracuse, NY); Oliphant, M.; Schneider, B.; Kavey, R.E.W.; Blackman, M.S.; Parker, F.B. Jr.

    1982-05-01

    To expand the search for central pulmonary arteries in six patients with absence of cardiac-pulmonary continuity, computerized axial tomography (CAT) of the chest was performed. The CAT scans were compared with previous arteriograms and pulmonary vein wedge angiograms. Three patients with type IV truncus arteriosus were studied, and none had a central, right or left pulmonary artery on CAT scan. However, two patients with tetralogy of Fallot with pulmonary atresia and a patent ductus arteriosus to the right lung demonstrated the presence of a left pulmonary artery. In addition, one child with truncus arteriosus with &apos;'absent'&apos; left pulmonary artery demonstrated a left pulmonary artery on the CAT scan. The CAT scan may therefore enhance our ability to search for disconnected pulmonary arteries in children with complex cyanotic congenital heart disease.

  16. Stars in the universe of &apos;&apos;green shares&apos;&apos;. Part 1. Energy; Sterne im gruenen Aktien-Universum. Teil 1. Energie

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, W. [Investmentclub, Berlin (Germany)

    2005-09-15

    There is a large choice of green shares available today. This four-instalment series will present more than 100 &apos;&apos;green shares&apos;&apos; of the various industries and will help to identify the offers marked as favourites by experts. (orig.)

  17. Hawai&apos;i&apos;s EVolution: Hawai&apos;i Powered. Technology Driven. (Brochure)

    Energy Technology Data Exchange (ETDEWEB)

    2013-05-01

    This Hawaii Clean Energy Initiative (HCEI) brochure outlines Hawaii&apos;s energy and transportation goals and the implementation of electric vehicles (EV) and electric vehicle infrastructure since HCEI began in 2008. It includes information about Hawaii&apos;s role in leading the nation in available EV charging infrastructure per capita; challenges for continuing to implement EV technology; features on various successful EV users, including the Hawaiian Electric Company, Enterprise Rent-A-Car, and Senator Mike Gabbard; how EVs can integrate into and help propel Hawaii&apos;s evolving smart grid; and much more.

  18. &apos;'Accelerated'&apos; filling of the Inden mine&apos;s residual lake from the Rur river; Die &apos;'beschleunigte'&apos; Befuellung des Tagebaurestsees Inden aus der Rur

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Andreas [RWE Power AG, Koeln (Germany); Koenzen, Uwe [Planungsbuero Koenzen - Wasser + Landschaft, Hilden (Germany); Lohr, Hubert [SYDRO Consult GmbH, Darmstadt (Germany); Hemmann, Regina; Mueller, Vera [Bezirksregierung Koeln, Koeln (Germany); Lange, Joachim [Wasserverband Eifel-Rur, Dueren (Germany)

    2013-03-01

    The Inden opencast lignite mine is located some 20 km to the north-east of Aachen in Germany&apos;s Rhineland. After the end of lignite mining around the year 2030, a lake measuring some 11.8 km{sup 2} is planned to be created. It will mainly be filled with water from the river Rur flowing past in the immediate vicinity of the opencast mine. Filling the lake volume of some 800 million m{sup 3} will take 20 to 25 years. During the past ten years, the basic water management questions arising in connection with the creation of the In den mine&apos;s residual lake were settled within the scope of the state-planning approval procedure.lt could be demonstrated by means of a numeric river catchment model that the envisaged withdrawal of water from the Rur is feasible and compatible with the water body&apos;s ecological and hydromorphological targets as well as its industrial use. (orig.)

  19. Yerel Cin Mısırı Genotiplerinin Kahramanmaraş Koşullarında Tarımsal Özelliklerinin Araştırılması

    OpenAIRE

    İDİKUT, Leyla; ZÜLKADİR, Gülay; YÜRÜRDURMAZ, Cengiz; ÇÖLKESEN, Mustafa

    2015-01-01

    ÖZET: Bu araştırma, ülkenin farklı yerlerinden toplanan 10 yerel popülasyon ile 2 yerel çeşit ve birde kompozit olmak üzere toplam 13 cin mısırı genotipi kullanılarak, Kahramanmaraş koşullarında iki (2012 ve 2013) yıl süreyle yürütülmüştür. Deneme tesadüf blokları deneme desenine göre dört tekerrürlü yürütülmüştür. Araştırmada cin mısırının tepe püskül çıkış süresi, koçan püskülü çıkış süresi, ilk koçan yüksekliği, bitki boyu, koçan uzunluğu, koçan çapı, koçanda sıra sayısı, koçan sırasına ta...

  20. Adolescent male reproductive responsibility.

    Science.gov (United States)

    Fox, L S

    1983-01-01

    A sample of 100 adolescent males enrolled in 2 high schools in suburban New Jersey completed a 30 item questionnaire in 1980 to explore further the attitudes and intended behavior of white, middle-class adolescent males regarding their reproductive responsibility. Data were sought on attitudes toward sex, contraception, pregnancy, and fatherhood. Also questioned were preferences about contraceptive use as well as anticipated behavior in the event of a partner's pregnancy. The study also was designed to obtain information on responses the subjects anticipated from their paretns on preferred pregnancy outcome. All respondents were white. 94%, based on data on the subjects' fathers, were ranked middle class and higher according to Hollingshead's Two Factor Index of Social Position. Ages ranged from 15-19 with a mean age of 16. 88% were living in households with both parents. Only 4% agreed that there was nothing wrong with telling a girl that you love her (even if you do not) so that she will agree to have sexual relations. This contrasts markedly with 61% of Vadies and Hale's lower-class sample of adolescent males who felt that deception was acceptable to obtain sex. 59% of the study group agreed that contraceptive use "shows concern for the girl," but the percentage dropped slightly to 53% regarding attitude toward using "protection whenever possible." The subjects demonstrated a contrast between attitude and intended behavior with 67% indicating an intention to use contraception when participating in sex regularly. 62% thought that for most of their peers would have sex and count on luck. 54% assumed that the "girl will protect herself." Respondents were more often willing either to help the close girlfriend range an abortion (28%), to marry her (21%), or to help her seek an adoption (20%). They were less likely to do the same for a casual girlfriend except in the case of abortion. A double standard was significantly evident on the basis of several preferred types

  1. Iran&apos;s &apos;Risk-Taking&apos; in Perspective

    Energy Technology Data Exchange (ETDEWEB)

    Shahram, Chubin

    2008-07-01

    Assessing any state&apos;s intentions is a difficult undertaking - especially at a specific moment in time. When a state is considered hostile, its behaviour erratic, and its system opaque, what is difficult under normal circumstances becomes nearly impossible. It may thus often seem prudent to attribute the worst of intentions to such states, but this can create a self-fulfilling prophecy. Iran with its revolutionary pretensions, fiery rhetoric and nuclear ambitions, is a case in point, since it is particularly difficult to &apos;read&apos;. Located in the centre of a geo-politically sensitive and conflict-driven area, Iran is in a position to influence - positively or otherwise - the Persian Gulf, the Caucasus, the Middle East and South Asia. This influence may furthermore be expanding as a result of the weakening of Iraq and Lebanon, divisions among the Palestinians, and the more general rise of the Shi&apos;i across the broader region. Add to this the ambiguous aims of Iran&apos;s nuclear programme and the shadow this has already thrown across the region, and the need to assess Iran&apos;s intentions accurately appears crucial. Here, Iran&apos;s past behavior may provide some help, especially when it comes to Iran&apos;s proclivity for risk taking - provided the acquisition of a nuclear capability does not alter Iran&apos;s intentions or behavior so as to make the past irrelevant. Some commentators believe that Iran&apos;s ideology and past behaviour suggest that a nuclear-capable Iran will be inclined to take on a high level of risk, without concern for the potential costs of this recklessness, and that Iran may perhaps even welcome the risks involved. By contrast, the recent National Intelligence Estimate (NIE), a composite of US intelligence agency estimates, has concluded that Iran&apos;s &apos;decisions are guided by a cost-benefit approach&apos; and therefore &apos;may be more vulnerable to influence&apos; than they had previously (i.e.2005) judged. These

  2. Occupational causes of male infertility

    DEFF Research Database (Denmark)

    Bonde, Jens P E

    2013-01-01

    To highlight and discuss the new evidence on occupational and environmental risk to male reproductive function.......To highlight and discuss the new evidence on occupational and environmental risk to male reproductive function....

  3. Phase equilibria in a system of &apos;breathing&apos; molecules

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Jianzhong; Prausnitz, John

    2001-09-30

    It is now well known that details in the intermolecular potential can significantly affect the qualitative features of a phase diagram where temperature is plotted against density for the coexistence curves among fluid and solid phases. While previous calculations of phase diagrams have assumed a time-invariant potential function, this report concerns the phase diagram for &apos;'breathing'&apos; molecules, i.e., molecules whose strength of intermolecular attraction fluctuates in time. Such fluctuations can occur in biomacromolecules where an active site can switch between &apos;'on'&apos; and &apos;'off'&apos; positions. Phase-equilibrium calculations were performed for molecules that have a periodic (breathing) attractive force in addition to the conventional intermolecular forces. The phase diagram for such molecules is as expected when the &apos;'breathing'&apos; properties are independent of density. However, when (more realistically), the &apos;'breathing'&apos; properties are density dependent, the phase diagram exhibits dramatic changes. These calculations may be useful for interpreting experimental data for protein precipitation, for plaque formation in blood vessels and for scaffold-supported tissue formation.

  4. [Treatment of male infertility].

    Science.gov (United States)

    Jardin, A

    1995-10-28

    Progress in medically assisted procreation has made it possible to obtain an embryon with a single spermatozoid or even a single spermatid. But such advanced technology must not overshadow the basic principles of patient management since there are many other medical or surgical possibilities for improving male fertility. Although the physiological mechanisms leading to azoospermia are relatively well understood, many questions remain as to the origin of oligo-asthenoteratospermia. Varicocela had been incriminated by many authors: in 25% of the cases, surgical care is followed by pregnancy. Other factors including autoimmunity, infection, environment and drugs also have an effect. Careful history taking can identify the main causes of male infertility before the problem of procreation occurs and in cases of definitive azoospermia the principles of management are relatively simple. The true problem is the fact that new techniques such as in vitro fertilization have acquired popularity in the general population but cannot be accepted as the gold standard by the medical community. It must not be forgotten that these artificial techniques cause a major psychological trauma to the couple and can lead to difficult situations (multiple pregnancies, extra embryos) with no totally satisfactory solution. PMID:8545356

  5. Impressive Offshore Rig Built &apos;&apos;in the Woods&apos;&apos;. Bentec launched new 2500 hp drilling rig for the Mittelplate field development

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2005-06-01

    In May international rig design and manufacturer Bentec Drilling and Oilfield Systems, a wholly-owned subsidiary of Abbot Group plc, unveiled the new 2500 hp rig T-150 it has been building for the Mittelplate Consortium (RWE Dea AG as operator/Wintershall AG) at Bentec&apos;s manufacturing facility &apos;&apos;in the woods&apos;&apos; of Bad Bentheim, Germany. (orig.)

  6. Why Germany&apos;s &apos;Messy&apos; energy transition should be a lesson to other nations

    International Nuclear Information System (INIS)

    Germany&apos;s so-called &apos;&apos;energy transition&apos;&apos; (&apos;'Energiewende'&apos;) is increasingly drawing the intention of the international community - but it seems for all the wrong reasons. US Senator Lamar Alexander said recently that German energy policy is one of the reasons the US should not abandon nuclear, but actually encourage increased investment in nuclear power plants. Alexander&apos;s remarks were made in an article published by the US Nuclear Energy Institute, in which he outlined his reasons why the US should not follow Germany&apos;s lead. Alexander rightly pointed out that the cost of attempting to replace nuclear power with wind, solar, and accompanying infrastructure is estimated by the German government at some 1.2 trillion US dollars (about 1 trillion Euros). The senator also made the point that Germany &apos;&apos;does not produce enough reliable, baseload energy for an important manufacturing economy&apos;&apos;. He also expressed concern at Germany&apos;s reliance on buying natural gas from Russia. While Germany has been forcing the closure of nuclear power plants others, including the oil-rich United Arab Emirates (UAE), have been investing in new nuclear, Alexander said. Judging from Alexander&apos;s remarks, it seems that Germany&apos;s energy transition experience will, after all, have a long-lasting legacy. That legacy will be a valuable lesson to other major industrialised nations in why they should not follow Germany&apos;s lead in abandoning a sensible energy mix, if they wish to maintain and develop economic and industrial productivity while keeping to international commitments to tackle climate change.

  7. KAKO PRIPREMITI STUDENTE SOCIJALNOG RADA ZA KRITIČKO MIŠLJENJE I DJELOVANJE U PODRUČJU MALOLJETNIČKE DELINKVENCIJE

    OpenAIRE

    Majdak, Marijana; Ajduković, Marina

    2003-01-01

    Zahtjevi suvremenog društva i ispitivanja poslodavaca pokazali su da se sveučilišna nastava treba mijenjati. S tim u vezi pristupilo se proučavanju metoda poučavanja koje potiču studente na kritičko mišljenje i aktivno djelovanje u visokoškolskoj nastavi kako bi obrazovani kadrovi mogli što bolje zadovoljiti zahtjeve koji im se na postavljaju radnoj karijeri, pa i općenito u životu. U svijetu se sve više nastavnika obrazuje tako da potiče kritičko mišljenje i aktivno učenje, a takvo je obrazo...

  8. Učinkovitost metode brain gym u radu s djecom sa specifičnim teškoćama u učenju

    OpenAIRE

    Zrilić, Smiljana; Marasović, Deniza; Perović, Anamarija

    2009-01-01

    U radu je predstavljena metoda Brain Gym te učinkovitost njezine primjene u radu s djecom sa specifi čnim teškoćama u učenju. Premda se učenici sa specifi čnim teškoćama u učenju često tretiraju kao neuspješni, praksa je pokazala da oni u pravilu nisu neuspješni u izvršavanju svih zadataka, u snalaženju u svim situacijama, da nisu neuspješni uvijek i sa svim ljudima. Okolina mora biti motivirajuća, na što najviše mogu utjecati učitelji, primjenjivanjem specifi čnih nastavnih metoda sa svrhom ...

  9. 7th CNS int&apos;l steam generators to controls conference - a compliment to the remarkable CNS &apos;OM+DM utility engagement initiative&apos;

    International Nuclear Information System (INIS)

    We learned from CANDU Maintenance-Conference of December 2011, that it is our own &apos;ways-of-working&apos; as service-providers for everything from plant-architecture to operational-support, that is holding back &apos;new-build&apos; as well as &apos;re-build&apos;. CMC2011 addressed that by focusing on &apos;Needs-and-Interests of the Operating-Utilities&apos;. SGC 2012 extends that by focusing firstly on &apos;Issue-Identification&apos; to isolate &apos;items-needing-attention&apos;; then on &apos;Issue-Definition&apos; to define the &apos;work&apos; required for &apos;Issue-Resolution&apos;. It also pursues &apos;Task Leadership&apos; as a competence, essential for ... &apos;making things happen&apos;. These events and the CNS &apos;OM+DM [Operations&Maintenance and Design&Materials Divisions] Utility Engagement Initiative&apos; are seen as complimentary initiatives toward such &apos;ways-of-working-improvement&apos; objectives. (author)

  10. 7th CNS int&apos;l steam generators to controls conference - a compliment to the remarkable CNS &apos;OM+DM utility engagement initiative&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, W. [Developer of Events for CNS OM+DM Divisions (Canada)

    2012-07-01

    We learned from CANDU Maintenance-Conference of December 2011, that it is our own &apos;ways-of-working&apos; as service-providers for everything from plant-architecture to operational-support, that is holding back &apos;new-build&apos; as well as &apos;re-build&apos;. CMC2011 addressed that by focusing on &apos;Needs-and-Interests of the Operating-Utilities&apos;. SGC 2012 extends that by focusing firstly on &apos;Issue-Identification&apos; to isolate &apos;items-needing-attention&apos;; then on &apos;Issue-Definition&apos; to define the &apos;work&apos; required for &apos;Issue-Resolution&apos;. It also pursues &apos;Task Leadership&apos; as a competence, essential for ... &apos;making things happen&apos;. These events and the CNS &apos;OM+DM [Operations&Maintenance and Design&Materials Divisions] Utility Engagement Initiative&apos; are seen as complimentary initiatives toward such &apos;ways-of-working-improvement&apos; objectives. (author)

  11. Social Service Professionals&apos; Perceptions of Nonoffending Caregivers in Child Sexual Abuse Cases

    Science.gov (United States)

    Wolfteich, Paula M.; Cline, Monica L.

    2013-01-01

    This study was designed to assess social service workers&apos; perceptions of nonoffending caregivers in cases of child sexual abuse. Attributions of blame were examined by administering questionnaires to staff at local social service agencies. It was hypothesized that social service workers who worked in the field longer, were male, or had less…

  12. Motivation for Reading and Upper Primary School Students&apos; Academic Achievement in Reading in Kenya

    Science.gov (United States)

    Mucherah, Winnie; Herendeen, Abbey

    2013-01-01

    This study examined primary school students&apos; reading motivation and performance on the standardized exam. Participants included 901 seventh and eighth grade students from Kenya. There were 468 females and 433 males. Contrary to previous studies, results showed reading challenge and aesthetics, but not efficacy, predicted reading achievement,…

  13. The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice.

    Science.gov (United States)

    Janssen, Carola I F; Jansen, Diane; Mutsaers, Martina P C; Dederen, Pieter J W C; Geenen, Bram; Mulder, Monique T; Kiliaan, Amanda J

    2016-01-01

    Apolipoprotein E4 (ApoE4), one of three common isoforms of ApoE, is a major risk factor for late-onset Alzheimer disease (AD). ApoE-deficient mice, as well as mice expressing human ApoE4, display impaired learning and memory functions and signs of neurodegeneration. Moreover, ApoE protects against high-fat (HF) diet induced neurodegeneration by its role in the maintenance of the integrity of the blood-brain barrier. The influence of a HF diet on the progression of AD-like cognitive and neuropathological changes was assessed in wild-type (WT), human ApoE4 and ApoE-knockout (ApoE-/-) mice to evaluate the modulatory role of ApoE in this process. From 12 months of age, female WT, ApoE4, and ApoE-/- mice were fed either a standard or a HF diet (19% butter, 0.5% cholate, 1.25% cholesterol) throughout life. At 15 months of age mice performed the Morris water maze, evaluating spatial learning and memory. ApoE-/- showed increased spatial learning compared to WT mice (p = 0.009). HF diet improved spatial learning in WT mice (p = 0.045), but did not affect ApoE4 and ApoE-/- mice. Immunohistochemical analyses of the hippocampus demonstrated increased neuroinflammation (CD68) in the cornu ammonis 1 (CA1) region in ApoE4 (p = 0.001) and in ApoE-/- (p = 0.032) mice on standard diet. HF diet tended to increase CD68 in the CA1 in WT mice (p = 0.052), while it decreased in ApoE4 (p = 0.009), but ApoE-/- remained unaffected. A trend towards increased neurogenesis (DCX) was found in both ApoE4 (p = 0.052) and ApoE-/- mice (p = 0.068). In conclusion, these data suggest that HF intake induces different effects in WT mice compared to ApoE4 and ApoE-/- with respect to markers for cognition and neurodegeneration. We propose that HF intake inhibits the compensatory mechanisms of neuroinflammation and neurogenesis in aged female ApoE4 and ApoE-/- mice. PMID:27171180

  14. The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice.

    Directory of Open Access Journals (Sweden)

    Carola I F Janssen

    Full Text Available Apolipoprotein E4 (ApoE4, one of three common isoforms of ApoE, is a major risk factor for late-onset Alzheimer disease (AD. ApoE-deficient mice, as well as mice expressing human ApoE4, display impaired learning and memory functions and signs of neurodegeneration. Moreover, ApoE protects against high-fat (HF diet induced neurodegeneration by its role in the maintenance of the integrity of the blood-brain barrier. The influence of a HF diet on the progression of AD-like cognitive and neuropathological changes was assessed in wild-type (WT, human ApoE4 and ApoE-knockout (ApoE-/- mice to evaluate the modulatory role of ApoE in this process. From 12 months of age, female WT, ApoE4, and ApoE-/- mice were fed either a standard or a HF diet (19% butter, 0.5% cholate, 1.25% cholesterol throughout life. At 15 months of age mice performed the Morris water maze, evaluating spatial learning and memory. ApoE-/- showed increased spatial learning compared to WT mice (p = 0.009. HF diet improved spatial learning in WT mice (p = 0.045, but did not affect ApoE4 and ApoE-/- mice. Immunohistochemical analyses of the hippocampus demonstrated increased neuroinflammation (CD68 in the cornu ammonis 1 (CA1 region in ApoE4 (p = 0.001 and in ApoE-/- (p = 0.032 mice on standard diet. HF diet tended to increase CD68 in the CA1 in WT mice (p = 0.052, while it decreased in ApoE4 (p = 0.009, but ApoE-/- remained unaffected. A trend towards increased neurogenesis (DCX was found in both ApoE4 (p = 0.052 and ApoE-/- mice (p = 0.068. In conclusion, these data suggest that HF intake induces different effects in WT mice compared to ApoE4 and ApoE-/- with respect to markers for cognition and neurodegeneration. We propose that HF intake inhibits the compensatory mechanisms of neuroinflammation and neurogenesis in aged female ApoE4 and ApoE-/- mice.

  15. Können Öko-Siegel einen neuen Handlungsspielraum für kleinbäuerliche Kaffeproduzenten schaffen? : das Beispiel Costa Rica

    OpenAIRE

    Mayer, C.

    2002-01-01

    Im letzten Jahrzehnt hat das Bestreben, soziale und ökologische Aspekte stärker in den Weltkaffeehandel zu integrieren, bedeutend zugenommen. Zum Einen, um die weltweit stetig wachsende Armut der Kaffeebauern und zum Anderen, um die ökologische Belastung beim Kaffeeanbau zu mindern. Es entstanden Öko-Siegel, die über die Vermittlung neuer Nachfrageimpulse nach ökologisch erzeugtem Kaffee einen Lösungsbeitrag für die Dilemmasituation des Verarmungsprozesses und des steigenden Re...

  16. [Ecclesia et civitatis : kościoł i życie religije w mieście średniowiecznym] / Raimo Pullat

    Index Scriptorium Estoniae

    Pullat, Raimo, 1935-

    2009-01-01

    Arvustus: Ecclesia et civitatis : kościoł i życie religije w mieście średniowiecznym. Pod redakcją Haliny Manikowskiej i Hanny Zaremskiej. Colloquia Mediaevalia Varsoviensia III. Warszawa : Instytut Historii PAN, 2002. Kollokviumi materjalide publikatsioonis käsitletakse peamiselt Sileesia, Preisimaa ja Pommeri linnu, mis käsitletaval perioodil kuulusid Poola koosseisu. Usuelu uurimise metodoloogiast.

  17. Calculation and consideration of the experimental correction factor of the prompt ko-factors for the development of the PGNAA database

    International Nuclear Information System (INIS)

    The prompt ko-factors are calculated for the light elements(Ao-factor, correction factor is derived for the case of the incident neutron spectrum containing epithermal component. For non-1/v absorbers, the correction factor is discussed in terms of the Westcott g-factors of the standard and comparator isotopes. Finally, the correction factor is derived for the polychromatic neutron beam of the PGNAA system in HANARO

  18. Phenological development of fagus sylvatica L. and Aesculus hipocastanum L. in relation to mean monthly temperatures for the Kočevje locality during 1961-1990

    OpenAIRE

    Vilhar, Urša; Kajfež-Bogataj, Lučka

    2003-01-01

    Long-term phenological development of forest trees and shrubs is an important indicator of changes in the onset of specific phenological phase at different sites in relation to meteorological conditions. Correlation analysis and linear multiple regression were used to establish relationship between phenological phases for Fagus sylvatica and Aesculus hippocastanum and mean monthly air temperatures for the Kočevje locality in the period 1961-1990. Correlation coefficients between the onset of ...

  19. PHOTOSYNTHETIC PIGMENT COMPOSITION OF ICE ALGAL AND PHYTOPLANKTON ASSEMBLAGES IN EARLY SPRING IN SAROMA KO LAGOON, HOKKAIDO, JAPAN (19th Symposium on Polar Biology)

    OpenAIRE

    カシノ, ヤスヒロ; フジモト, クミコ; アカマツ, アケミ; コイケ, ヒロユキ; サトウ, カズヒコ; クドウ, サカエ; Yasuhiro, Kashino; Kumiko, FUJIMOTO; Akemi, AKAMATSU; Hiroyuki, KOIKE; Kazuhiko, SATOH; Sakae, KUDOH

    1998-01-01

    Ice algae were collected from sea ice of 35 cm thickness at Saroma Ko lagoon in early February, 1996 The sea ice was sectioned into 5cm height intervals from the bottom so as to separate ice algae according to vertical distribution. Phytoplankton were also harvested at the same site in mid-April, 1996, a few days after the sea ice disappeared. Photosynthetic pigments of ice algae and phytoplanktonic algae were analyzed by reverse-phase HPLC (high performance liquid chromatography). Chlorophyl...

  20. Využití odpadních plastů ko-pyrolýzou s uhlím

    Czech Academy of Sciences Publication Activity Database

    Kříž, Vlastimil; Chovancová, P.; Buchtele, Jaroslav

    Košice: Cpress, 2001, s. 59-66. ISBN 80-7099-693-5. [Medzinárodná konferencia Metalurgia a environmentálne technologie/2./. Herlany (SK), 11.09.2001-12.09.2001] R&D Projects: GA ČR GA105/01/0332 Institutional research plan: CEZ:AV0Z3046908 Keywords : waste plastic * coal Subject RIV: DH - Mining, incl. Coal Mining

  1. Trace elements and antioxidants in Astragalus onobrychis L. var. chlorocarpus (Griseb.) S. Kožuharov et D.K. Pavlova

    OpenAIRE

    Miladinović Dragoljub L.; Ilić Budimir S.; Milosavljević Violeta N.

    2011-01-01

    Leaves of growing-wild species Astragalus onobrychis L. var. chlorocarpus (Griseb.) S. Kožuharov et D. K. Pavlova were collected during the different stages of growth and analyzed for iron (Fe), copper (Cu), zinc (Zn), manganese (Mn), soluble proteins, reduced glutathione (GSH), total flavonoid and total carotenoid contents. Iron, copper and manganese have shown similar seasonal pattern, increasing of metal content in leaves during the vegetative period. The highest values of the examin...

  2. Galanin-like peptide (GALP) neurone-specific phosphoinositide 3-kinase signalling regulates GALP mRNA levels in the hypothalamus of males and luteinising hormone levels in both sexes.

    Science.gov (United States)

    Aziz, R; Beymer, M; Negrón, A L; Newshan, A; Yu, G; Rosati, B; McKinnon, D; Fukuda, M; Lin, R Z; Mayer, C; Boehm, U; Acosta-Martínez, M

    2014-07-01

    Galanin-like peptide (GALP) neurones participate in the metabolic control of reproduction and are targets of insulin and leptin regulation. Phosphoinositide 3-kinase (PI3K) is common to the signalling pathways utilised by both insulin and leptin. Therefore, we investigated whether PI3K signalling in neurones expressing GALP plays a role in the transcriptional regulation of the GALP gene and in the metabolic control of luteinising hormone (LH) release. Accordingly, we deleted PI3K catalytic subunits p110α and p110β via conditional gene targeting (cKO) in mice (GALP-p110α/β cKO). To monitor PI3K signalling in GALP neurones, these animals were also crossed with Cre-dependent FoxO1GFP reporter mice. Compared to insulin-infused control animals, the PI3K-Akt-dependent FoxO1GFP nuclear exclusion in GALP neurones was abolished in GALP-p110α/β cKO mice. We next used food deprivation to investigate whether the GALP-neurone specific ablation of PI3K activity affected the susceptibility of the gonadotrophic axis to negative energy balance. Treatment did not affect LH levels in either sex. However, a significant genotype effect on LH levels was observed in females. By contrast, no genotype effect on LH levels was observed in males. A sex-specific genotype effect on hypothalamic GALP mRNA was observed, with fed and fasted GALP-p110α/β cKO males having lower GALP mRNA expression compared to wild-type fed males. Finally, the effects of gonadectomy and steroid hormone replacement on GALP mRNA levels were investigated. Compared to vehicle-treated mice, steroid hormone replacement reduced mediobasal hypothalamus GALP expression in wild-type and GALP-p110α/β cKO animals. In addition, within the castrated and vehicle-treated group and compared to wild-type mice, LH levels were lower in GALP-p110α/β cKO males. Double immunofluorescence using GALP-Cre/R26-YFP mice showed androgen and oestrogen receptor co-localisation within GALP neurones. Our data demonstrate that GALP

  3. The state and means for developing efforts to regulate drilling mud types at the &apos;'Permneft''&apos; union

    Energy Technology Data Exchange (ETDEWEB)

    Krysin, N.I.; Minaeva, R.M.; Sukhikh, U.M.

    1979-01-01

    Service water has been most widely used as a drilling mud at the &apos;'Permneft''&apos; union. Emulsion mud and emulsion mud-carbonated drilling mud are also widely used. In unstable rock areas, flushing is conducted using calcium chloride mud drilling solutions and mud drilling solutions with natural subsalt mineralization. The use of various types of drilling muds is analyzed. The following were the primary indicators in the analysis: the specific weight of the expenditures on drilling solution materials in the overall cost of borehole construction and the expenses on materials for 1 meter of drilling. The types of drilling solutions recommended for use in different fields in specific geological conditions are determined. The drilling solution standards are compared based on the results of an analysis and the reference materials of the All-Union Scientific Research Institute on Comprehensive Oil Solutions. An examination proceedure is described, together with the regulation acceptances and directions for improving them.

  4. A Survey of Open Clusters in the u&apos;g'r'i'z&apos; Filter System. 3. Results for the Cluster NGC 188

    Energy Technology Data Exchange (ETDEWEB)

    Fornal, Bartosz; Tucker, Douglas L.; Smith, J.Allyn; Allam, Sahar S.; Rider, Cristin J.; Sung, Hwankyung; /Jagiellonian U. /Fermilab /Austin Peay State U. /Wyoming U. /Johns Hopkins U. /Sejong U.

    2006-11-01

    The authors continue the series of papers describing the results of a photometric survey of open star clusters, primarily in the southern hemisphere, taken in the u&apos;g'r'i'z&apos; filter system. The entire observed sample covered more than 100 clusters, but here they present data only on NGC 188, which is one of the oldest open clusters known in the Milky Way. They fit the Padova theoretical isochrones to the data. Assuming a solar metallicity for NGC 188, they find a distance of 1700 {+-} 100 pc, an age of 7.5 {+-} 0.7 Gyr, and a reddening E(B-V) of 0.025 {+-} 0.005. This yields a distance modulus of 11.23 {+-} 0.14.

  5. Čistící účinnost vertikálních kořenových filtrů

    OpenAIRE

    Opletal, Jan

    2014-01-01

    Cílem této práce bylo zjištění čistící účinnosti vertikálních kořenových filtrů. Z analýzy dat kořenové čistírny v Kotenčicích jsem došel k závěru, vertikální pulzně skrápěný kořenový filtr dosahuje nejlepších výsledků v odstranění znečištění z odpadní vody. Jedinou jeho nevýhodou byl slabý průběh denitrifikace. Vertikální filtr byl srovnáván se sérií horizontálního a vertikálního kontinuálně protékaného filtru, které sice nemohly konkurovat vertikálnímu filtru ale i přesto účinně odstraňoval...

  6. Voices in Transition: Testosterone, Transmasculinity, and the Gendered Voice among Female-to-Male Transgender People

    Science.gov (United States)

    Zimman, Lal

    2012-01-01

    This dissertation is based on a long-term ethnographic and sociophonetic study of 15 transgender people on the female-to-male (or "transmasculine") identity spectrum. The focus of the study is the way these individuals&apos; voices change during the first 1-2 years of masculinizing hormone therapy, which brings about a drop in vocal…

  7. Setting an Egalitarian Social Norm in the Classroom: Improving Attitudes towards Diversity among Male Engineering Students

    Science.gov (United States)

    Bennett, Jill E.; Sekaquaptewa, Denise

    2014-01-01

    This study tested the effect of a message describing a social norm of egalitarian attitudes and behaviors in an engineering college on male students&apos; attitudes and behavioral intentions surrounding diversity in engineering. Participants were first-semester university students enrolled in four sections of an introductory engineering course in…

  8. Celebrity Chefs and Masculinities among Male Cookery Trainees in Vocational Education

    Science.gov (United States)

    Steno, Anne Mia; Friche, Nanna

    2015-01-01

    The purpose of this article is to examine how media-generated professional identities in the culinary sector are reflected in Danish male cookery students&apos; narratives about their own identity, experiences and expectations about the trade. Hence, this study takes its starting point in studies that show how the broad popularity of the culinary…

  9. Mito e realtà della letteratura ebraica al femminile in Germania: Anna Seghers e Mascha Kaléko

    Directory of Open Access Journals (Sweden)

    Karin Birge Gilardoni-Büch

    2014-04-01

    Full Text Available Is there a typical Jewish and female fashion in writing literature? And which kind of criteria could one employ in order to answer such a question? We could try to reply in two ways: a explaining the terms of the discussion, their origin and how they are employed; b or interpreting the empirical data, i.e., the texts written by women with a Jewish origin. If the roots of typical “women writing” can be drawn back to the literary studies of the 20th century and to the endeavour of historians of literature (men to find a common denominator for a phenomenon which was becoming more and more visible, i.e., the growing number of female writers, it may be enough to look at the Weimarer Republic to see that the existence of a sort of “Hebraism in writing” cannot be taken for granted. During those years, a German-Jewish symbiosis was reaching the zenith, with its pressure for assimilation and a self-understanding of oneself as German more than Jewish. Anyway, a real Jewish identity will only take shape after the Nazis' takeover and the following exclusion of the Jews from everyday life, the deletion of their personal freedom and the forced alienation of their belongings (the so-called “aryanization”. Suddenly, the German Jews were forced “into situations they never perceived or looked for before” (Silvia Schlenstedt. On this background, and from a present point of view, Jewish identity took shape as an effort to face the experience of pain: the Shoah. The effort to keep Jewish traditions and topics alive through writing was an answer to the project of deleting every trace of a Jewish life not only from Germany but also from every part of Europe. The poems written by Gertrud Kolmar (1894-1943, Else Lasker-Schüler (1869-1945, Ilse Blumenthal-Weiss (1899-1987, Nelly Sachs (1891-1970 give enough evidence of this.However, maybe one cannot say the same for Anna Seghers (1900-1983 and Mascha Kaléko (1907-1975. Both authors were crowned with

  10. A rare disease in an atypical location - Kimura&apos;s Disease of the upper extremity

    Energy Technology Data Exchange (ETDEWEB)

    Lam, Alan Cheuk Si; Lau, Vince Wing Hang [Queen Mary Hospital, Department of Radiology, Hong Kong (China); Au Yeung, Rex Kwok Him [University of Hong Kong, Department of Pathology, Li Ka Shing Faculty of Medicine, Hong Kong (China)

    2015-12-15

    Kimura&apos;s disease is a rare chronic inflammatory disorder predominantly affecting young Asian male patients, occurring mainly in the head and neck regions. Kimura&apos;s disease of the upper extremity is extremely rare, and previous case reports in the literature show similar imaging characteristics with consistent location at the medial epitrochlear region, predominantly with unilateral involvement. We present the first reported case of Kimura&apos;s disease affecting the anterolateral aspect of the upper arm, sparing the medial epitrochlear region, illustrating that with typical MR appearance and serology, the involvement of this rare disease in an atypical location still warrants consideration of this diagnosis. There was also bilateral asymmetrical involvement in our patient, suggesting the possibility of a propensity for Kimura&apos;s disease affecting the upper extremities to have bilateral involvement, which may necessitate imaging of the clinically asymptomatic contralateral limb in these patients for early lesion identification and treatment. (orig.)

  11. Hyperthermal molecular beam scattering: K--O2 ion/neutral product angular, energy, and branching ratio analysis

    International Nuclear Information System (INIS)

    Angular distributions of K+ ions and K atoms from collisions of a beam of hyperthermal K atoms with a cross beam of thermal O2 molecules were determined in the range from 18 to 38 eV (lab). A pronounced rainbow was observed in the ion-pair channel at a reduced angle of 240 eV deg. A smaller rainbow was also found in the neutral channel at 220 eV deg. Energy loss distributions for both product species were also determined at 28 eV (lab) by time-of-flight measurements. Both K+ ions and K atoms from K+O2 were detected concurrently. A pseudorandom pulsing method was used to increase the duty cycle. The TOF spectra indicated overlapping energy-loss distributions corresponding to ground and excited state formation for both the neutral and ion products. Excited state to ground state branching ratios for both the neutral and ion products were determined as a function of reduced angle. The neutral branching ratio shows a pronounced peak at approx.180 eV deg., while the ion ratio increases rapidly above 200 eV deg. From these ratios the differential cross sections were calculated for neutral K in which either K or O2 is electronically excited. These cross sections are similar to the differential cross sections of K+ ions. The neutral to ion branching ratios, also determined, exhibit a broad minimum in the vicinity of the rainbow angle. Differential cross sections for neutral and ion scattering were integrated to give the total neutral/ion branching ratio of approx.4. A preliminary analysis of the experimental differential cross sections has been performed via an atom--atom model. Although the model has substantial and expected deficiencies, the analysis strongly indicates that the quartet surfaces emanating from the neutral ground electronic asymptote must be substantially more repulsive than the corresponding doublet surface

  12. Content of metals and metabolites in honey originated from the vicinity of industrial town Košice (eastern Slovakia).

    Science.gov (United States)

    Kováčik, Jozef; Grúz, Jiří; Biba, Ondřej; Hedbavny, Josef

    2016-03-01

    Composition of three types of honey (mixed forest honey and monofloral-black locust and rapeseed honeys) originated from the vicinity of an industrial town (Košice, Slovak Republic) was compared. Higher content of minerals including toxic metals in forest honey (1358.6 ng Ni/g, 85.6 ng Pb/g, and 52.4 ng Cd/g) than in rapeseed and black locust honeys confirmed that botanical origin rather than the distance for eventual source of pollution (steel factory) affects metal deposition. Benzoic acid derivatives were typically more accumulated in forest but cinnamic acid derivatives and some flavonoids in rapeseed honey (in free and/or glycoside-bound fraction). In terms of quantity, p-hydroxybenzoic and p-coumaric acids were mainly abundant. Total phenols, thiols, and proteins were abundant in forest honey. Some metals and phenols contributed to separation of honeys based on principal component analysis (PCA). Native amount of 5-(hydroxymethyl)furfural was not related to honey type (~11 μg/g) and was elevated after strong acid hydrolysis (200-350 μg/g) but it did not interfere with the assay of phenols by Folin-Ciocalteu reagent. This is the first report of metals and metabolites in the same study, and data are discussed with available literature. We conclude that black locust (acacia) honey is the most suitable for daily use and that central European monofloral honeys contain lower amounts of toxic metals in comparison with other geographical regions. PMID:26517990

  13. [Mercury in edible mushrooms from the area of Kościersk forests and from the Vistula peninsula].

    Science.gov (United States)

    Falandysz, J; Marcinowicz, A; Chwir, A

    1996-01-01

    The total mercury concentrations were determined in caps and stalks or a whole fruiting bodies of 13 species of edible mushrooms collected at the area of Kościerzyna forests (District of Gdańsk) and the Vistula Peninsula (District of Elblag) in 1993/94. The method of measurement was cold-vapour atomic absorption spectrometry (CV-AAS) after wet digestion of the samples with concentrated nitric acid. Macrolepiota procera showed highest mercury concentration among species investigated and contained, respectively, 1100 micrograms/kg dry wt in caps and 580 micrograms/kg in stalks, while Lycoperdon perlatum showed 1100 micrograms/kg in a whole fruiting body. Suillus granulatus, Xerocomus subtomentosus, Leccinum scabrum, Oudemansiella platyphylla and Lactarius delicious contained mercury in concentration from 150 to 370 micrograms/kg dry wt in caps and from 70 to 180 micrograms/kg in stalks. Suillus bovinus, Chroogomphus rutilus and Armillariella mellea showed smallest concentrations of mercury between species examined, i.e. in caps from 29 to 65 micrograms/kg and in stalks from 23 to 49 micrograms/kg, on a average. Leccinum scabrum and Xerocomus badius were collected from the both distant in space sampling sites. In the case of L. scabrum the concentrations of mercury were very similar for the both sites investigated, i.e. between 290 +/- 100 and 370 +/- 330 in caps, and 180 +/- 60 and 220 +/- 160 micrograms/kg dry wt in stalks, while for X. badius differed and were between 73 +/- 20 and 220 +/- 60 in caps, and 49 +/- 13 and 130 +/- 40 in stalks (p < 0.001). PMID:9064742

  14. Reflection group on &apos;Expert Culture&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Eggermont, G

    2000-07-01

    As part of SCK-CEN&apos;s social sciences and humanities programme, a reflection group on &apos;Expert Culture&apos; was established. The objectives of the reflection group are: (1) to clarify the role of SCK-CEN experts; (2) to clarify the new role of expertise in the evolving context of risk society; (3) to confront external views and internal SCK-CEN experiences on expert culture; (4) to improve trust building of experts and credibility of SCK-CEN as a nuclear actor in society; (5) to develop a draft for a deontological code; (6) to integrate the approach in training on assertivity and communication; (7) to create an output for a topical day on the subject of expert culture. The programme, achievements and perspectives of the refection group are summarised.

  15. ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations.

    Directory of Open Access Journals (Sweden)

    Benfeard Williams

    2015-10-01

    Full Text Available The increased risk of developing Alzheimer's disease (AD is associated with the APOE gene, which encodes for three variants of Apolipoprotein E, namely E2, E3, E4, differing only by two amino acids at positions 112 and 158. ApoE4 is known to be the strongest risk factor for AD onset, while ApoE3 and ApoE2 are considered to be the AD-neutral and AD-protective isoforms, respectively. It has been hypothesized that the ApoE isoforms may contribute to the development of AD by modifying the homeostasis of ApoE physiological partners and AD-related proteins in an isoform-specific fashion. Here we find that, despite the high sequence similarity among the three ApoE variants, only ApoE4 exhibits a misfolded intermediate state characterized by isoform-specific domain-domain interactions in molecular dynamics simulations. The existence of an ApoE4-specific intermediate state can contribute to the onset of AD by altering multiple cellular pathways involved in ApoE-dependent lipid transport efficiency or in AD-related protein aggregation and clearance. We present what we believe to be the first structural model of an ApoE4 misfolded intermediate state, which may serve to elucidate the molecular mechanism underlying the role of ApoE4 in AD pathogenesis. The knowledge of the structure for the ApoE4 folding intermediate provides a new platform for the rational design of alternative therapeutic strategies to fight AD.

  16. OF &apos;COCKTAIL PARTIES&apos; AND EXOPLANETS

    Energy Technology Data Exchange (ETDEWEB)

    Waldmann, I. P., E-mail: ingo@star.ucl.ac.uk [University College London, Gower Street, WC1E 6BT (United Kingdom)

    2012-03-01

    The characterization of ever smaller and fainter extrasolar planets requires an intricate understanding of one&apos;s data and the analysis techniques used. Correcting the raw data at the 10{sup -4} level of accuracy in flux is one of the central challenges. This can be difficult for instruments that do not feature a calibration plan for such high precision measurements. Here, it is not always obvious how to de-correlate the data using auxiliary information of the instrument and it becomes paramount to know how well one can disentangle instrument systematics from one&apos;s data, given nothing but the data themselves. We propose a non-parametric machine learning algorithm, based on the concept of independent component analysis, to de-convolve the systematic noise and all non-Gaussian signals from the desired astrophysical signal. Such a &apos;blind&apos; signal de-mixing is commonly known as the &apos;Cocktail Party problem&apos; in signal processing. Given multiple simultaneous observations of the same exoplanetary eclipse, as in the case of spectrophotometry, we show that we can often disentangle systematic noise from the original light-curve signal without the use of any complementary information of the instrument. In this paper, we explore these signal extraction techniques using simulated data and two data sets observed with the Hubble Space Telescope NICMOS instrument. Another important application is the de-correlation of the exoplanetary signal from time-correlated stellar variability. Using data obtained by the Kepler mission we show that the desired signal can be de-convolved from the stellar noise using a single time series spanning several eclipse events. Such non-parametric techniques can provide important confirmations of the existent parametric corrections reported in the literature, and their associated results. Additionally they can substantially improve the precision exoplanetary light-curve analysis in the future.

  17. The role of APOE in cerebrovascular dysfunction.

    Science.gov (United States)

    Tai, Leon M; Thomas, Riya; Marottoli, Felecia M; Koster, Kevin P; Kanekiyo, Takahisa; Morris, Alan W J; Bu, Guojun

    2016-05-01

    The ε4 allele of the apolipoprotein E gene (APOE4) is associated with cognitive decline during aging, is the greatest genetic risk factor for Alzheimer's disease and has links to other neurodegenerative conditions that affect cognition. Increasing evidence indicates that APOE genotypes differentially modulate the function of the cerebrovasculature (CV), with apoE and its receptors expressed by different cell types at the CV interface (astrocytes, pericytes, smooth muscle cells, brain endothelial cells). However, research on the role of apoE in CV dysfunction has not advanced as quickly as other apoE-modulated pathways. This review will assess what aspects of the CV are modulated by APOE genotypes during aging and under disease states, discuss potential mechanisms, and summarize the therapeutic significance of the topic. We propose that APOE4 induces CV dysfunction through direct signaling at the CV, and indirectly via modulation of peripheral and central pathways. Further, that APOE4 predisposes the CV to damage by, and exacerbates the effects of, additional risk factors (such as sex, hypertension, and diabetes). ApoE4-induced detrimental CV changes include reduced cerebral blood flow (CBF), modified neuron-CBF coupling, increased blood-brain barrier leakiness, cerebral amyloid angiopathy, hemorrhages and disrupted transport of nutrients and toxins. The apoE4-induced detrimental changes may be linked to pericyte migration/activation, astrocyte activation, smooth muscle cell damage, basement membrane degradation and alterations in brain endothelial cells. PMID:26884068

  18. Keanakākoʻi Tephra produced by 300 years of explosive eruptions following collapse of Kīlauea's caldera in about 1500 CE

    Science.gov (United States)

    Swanson, Donald A.; Rose, Timothy R.; Fiske, Richard S.; McGeehin, John P.

    2012-01-01

    The Keanakākoʻi Tephra at Kīlauea Volcano has previously been interpreted by some as the product of a caldera-forming eruption in 1790 CE. Our study, however, finds stratigraphic and 14C evidence that the tephra instead results from numerous eruptions throughout a 300-year period between about 1500 and 1800. The stratigraphic evidence includes: (1) as many as six pure lithic ash beds interleaved in sand dunes made of earlier Keanakākoʻi vitric ash, (2) three lava flows from Kīlauea and Mauna Loa interbedded with the tephra, (3) buried syneruptive cultural structures, (4) numerous intraformational water-cut gullies, and (5) abundant organic layers rich in charcoal within the tephra section. Interpretation of 97 new accelerator mass spectrometry (AMS) 14C ages and 4 previous conventional ages suggests that explosive eruptions began in 1470–1510 CE, and that explosive activity continued episodically until the early 1800s, probably with two periods of quiescence lasting several decades. Kīlauea's caldera, rather than forming in 1790, predates the first eruption of the Keanakākoʻi and collapsed in 1470–1510, immediately following, and perhaps causing, the end of the 60-year-long, 4–6 km3 ʻAilāʻau eruption from the east side of Kīlauea's summit area. The caldera was several hundred meters deep when the Keanakākoʻi began erupting, consistent with oral tradition, and probably had a volume of 4–6 km3. The caldera formed by collapse, but no eruption of lava coincided with its formation. A large volume of magma may have quickly drained from the summit reservoir and intruded into the east rift zone, perhaps in response to a major south-flank slip event, leading to summit collapse. Alternatively, magma may have slowly drained from the reservoir during the prolonged ʻAilāʻau eruption, causing episodic collapses before the final, largest downdrop took place. Two prolonged periods of episodic explosive eruptions are known at Kīlauea, the Keanakāko

  19. &apos;&apos;Rio+20 on site&apos;&apos;. Communities on their way to sustainability. Examples from Germany; &apos;&apos;Rio+20 vor Ort&apos;&apos;. Kommunen auf dem Weg zur Nachhaltigkeit. Beispiele aus Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Nolting, Katrin; Goell, Edgar

    2012-03-15

    20 years ago, the international community adopted the concept of &apos;sustainable development&apos; as a model for the 21st century adopted in order to meet the growing challenges facing the mankind. With Agenda 21, the UN presented a global action plan for the implementation of such a sustainable development. This brochure provides an insight into sustainability activities at local level in Germany. It is shown how such activities result in future-oriented and exemplary developments in some areas and selected areas of action.

  20. Intelligent marketing of electricity from decentral power sources. Project results of the research project &apos;'Massig'&apos;; Intelligente Vermarktung von Strom aus dezentralen Energiequellen. Projektergebnisse des Forschungsvorhabens &apos;'Massig'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Erge, Thomas; Sauer, Christian [Fraunhofer-Institut fuer Solare Energiesysteme ISE, Freiburg (Germany); Barnsteiner, Martin; Preiser, Klaus [Badenova Waermeplus GmbH und Co.KG, Freiburg (Germany)

    2011-07-01

    In the European research project &apos;Market Access for Smaller Size Intelligent Electricity Generation (Massig)&apos; scientists at the Fraunhofer Institute for Solar Energy Systems (Freiburg, Federal Republic of Germany) examined together with project partners the demand-oriented supply and commercialization of electricity from decentral power generators at the liberalized electricity market. The project team selected target countries and evaluated innovative solutions of marketing especially for specific applications of practice. Such a model project is that of Badenova Waermeplus GmbH (Freiburg, Federal Republic of Germany).

  1. ApoE Isoform-Dependent Deficits in Extinction of Contextual Fear Conditioning

    OpenAIRE

    Olsen, Reid H. J.; Agam, Mati; Davis, Matthew James; Raber, Jacob

    2012-01-01

    The three major human apoE isoforms (apoE2, apoE3, and apoE4) are encoded by distinct alleles (ε2, ε3, and ε4). Compared to ε3, ε4 is associated with increased risk to develop Alzheimer’s disease (AD), cognitive impairments in Parkinson’s disease (PD), and other conditions. In contrast, a recent study indicated an increased susceptibility to the recurring and re-experiencing symptom cluster of Post Traumatic Stress Disorder (PTSD), as well as related memory impairments, in patients carrying a...

  2. ApoE Production in Human Monocytes and Its Regulation by Inflammatory Cytokines

    OpenAIRE

    Braesch-Andersen, Sten; Paulie, Staffan; Smedman, Christian; Mia, Sohel; Kumagai-Braesch, Makiko

    2013-01-01

    The apoE production by tissue macrophages is crucial for the prevention of atherosclerosis and the aim of this study was to further elucidate how this apolipoprotein is regulated by cytokines present during inflammation. Here we studied apoE production in peripheral blood mononuclear cells (PBMC) and analysis was made with a newly developed apoE ELISpot assay. In PBMC, apoE secretion was restricted to monocytes with classical (CD14++CD16−) and intermediate (CD14+CD16+) monocytes being the mai...

  3. Ko-RFID Abschlussbericht

    OpenAIRE

    Straube, Frank; Fürstenberg, Frank; Bensel, Philipp; Vogeler, Stefan

    2010-01-01

    Unter dem Titel „Kollaboration in RFID-gestützten Wertschöpfungsnetzen“ arbeiteten die Projektpartner über den Zeitraum von drei Jahren an den folgenden Fragestellungen: Welche Rolle spielt Vertrauen in unternehmensübergreifende RFID-Anwendungen? Wie kann ein Vertrauensverhältnis erzeugt werden? Wie können ungleichmäßige Kosten/Nutzen-Aufteilungen unternehmensübergreifender RFID-Anwendungen gelöst werden, um zu einer Win-Win-Situation zu gelangen? Welche Potenziale ergeben sich fü...

  4. KO88 METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  5. Danskernes hellige ko

    DEFF Research Database (Denmark)

    Smed, Sinne

    Denne afhandling omhandler tre unge senmoderne storbydrenges sproglige og sociale hverdag i en skole og i en ungdomsklub på Amager. Fokus for afhandlingen er at belyse, hvordan drengene konstruerer og forhandler identiteter i interaktionen med hinanden og deres omgivelser i forskellige skole- og ...

  6. Reduced Metabolsim in Brain &apos;Control Networks&apos; Following Cocaine-Cues Exposure in Female Cocaine Abusers

    Energy Technology Data Exchange (ETDEWEB)

    Volkow, N.D.; Wang, G.; Volkow, N.D.; Tomasi, D.; Wang, G.-J.; Fowler, J.S.; Telang, F.; Goldstein, R.Z.; Alia-Klein, N.; Wong, C.T.

    2011-03-01

    Gender differences in vulnerability for cocaine addiction have been reported. Though the mechanisms are not understood, here we hypothesize that gender differences in reactivity to conditioned-cues, which contributes to relapse, are involved. To test this we compared brain metabolism (using PET and {sup 18}FDG) between female (n = 10) and male (n = 16) active cocaine abusers when they watched a neutral video (nature scenes) versus a cocaine-cues video. Self-reports of craving increased with the cocaine-cue video but responses did not differ between genders. In contrast, changes in whole brain metabolism with cocaine-cues differed by gender (p<0.05); females significantly decreased metabolism (-8.6% {+-} 10) whereas males tended to increase it (+5.5% {+-} 18). SPM analysis (Cocaine-cues vs Neutral) in females revealed decreases in frontal, cingulate and parietal cortices, thalamus and midbrain (p<0.001) whereas males showed increases in right inferior frontal gyrus (BA 44/45) (only at p<0.005). The gender-cue interaction showed greater decrements with Cocaine-cues in females than males (p<0.001) in frontal (BA 8, 9, 10), anterior cingulate (BA 24, 32), posterior cingulate (BA 23, 31), inferior parietal (BA 40) and thalamus (dorsomedial nucleus). Females showed greater brain reactivity to cocaine-cues than males but no differences in craving, suggesting that there may be gender differences in response to cues that are not linked with craving but could affect subsequent drug use. Specifically deactivation of brain regions from &apos;control networks&apos; (prefrontal, cingulate, inferior parietal, thalamus) in females could increase their vulnerability to relapse since it would interfere with executive function (cognitive inhibition). This highlights the importance of gender tailored interventions for cocaine addiction.

  7. Optimisation of biological reactors using the &apos;biological resonance&apos; phenomenon; Ansatz zur Optimierung biologischer Reinigungsstufen durch das Phaenomen der &apos;&apos;Biologischen Resonanz&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Schmid, A.

    2003-07-01

    The microbial catabolic activity of biological reactors can be increased by up to 75% through external stimulation with intermittent stress loads at intervals of several minutes. Under these process conditions, the &apos;&apos;biological resonance&apos;&apos; phenomenon determines the system and leads to an increased synthesis of enzymes. In addition to computer simulations, experiments with activated sludge were carried out in a 10-litre bioreactor. By modulating the stress intervals, a permanent increase in catabolic activity of about 60% was achieved during these experiments. By relying on the &apos;&apos;biological resonance&apos;&apos; phenomenon, the required reaction volume of biological treatment units can probably be reduced by up to 40%. (orig.)

  8. Ethanolic fermentation of sucrose, sugarcane juice and molasses by Escherichia coli strain ko11 and Klebsiella oxytoca strain P2 Fermentação etanólica de sacarose, caldo de cana-de-açúcar e de melaço por Escherichia coli KO11 e Klebsiella oxytoca P2

    Directory of Open Access Journals (Sweden)

    Gervásio P. da Silva

    2005-12-01

    Full Text Available Escherichia coli KO11 and Klebsiella oxytoca P2 recombinants fermented sucrose to ethanol. In minimal medium with 2% or 12% added sucrose KO11 produced 75% and 41%, respectively, of the maximum theoretical yield (0.54g ethanol/g sucrose. In Luria-Bertani (LB broth with up to 8% sucrose, KO11 presented a 94-96% yield and with 12% sucrose, KO11 presented about 69% yield (44.5g ethanol/L. P2 presented 55% of the theoretical maximum yield in minimal medium supplemented with 2% sucrose and 47% of the maximum in 12% sucrose. In LB broth with 2 or 4% sucrose, P2 presented 94-95% of the theoretical maximum yield, which fell to 73% with 8% added sucrose (31.4g ethanol/L and 58% with 12% sucrose (37.5 g/L. Volumetric productivity in LB broth containing 2% sucrose was 0.41 g/L/h for KO11 and 1.1 g/L/h for P2, while in LB broth with 12% added sucrose, productivity was 0.96 g/L/h (KO11 and 1.4 g/L/h (P2. During fermentation of sugar cane juice by E. coli KO11 and K. oxytoca P2 produced 39.4 g/L and 42.1 g/L ethanol when supplemented with 0.5% yeast extract, micronutrients and thiamine. In sugar cane juice supplemented with LB broth ingredients, KO11 ethanol fermentation was inhibited with production of only 23.0 g ethanol/L, while P2 produced 44.2 g/L. Ethanol production by KO11 and P2, respectively, in sugarcane juice was a 25.3 and 30.2 g/L with 0.2% ammonium sulfate, b 24.9 and 31.6 g/L with ammonium sulfate and micronutrients, c 25.6 and 37.5 g/L with ammonium sulfate, micronutrients and thiamine. During molasses fermentation E. coli KO11 presented low ethanol production and high lactic acid production. K. oxytoca P2 produced 25 g ethanol/L in molasses diluted 10-fold in water, with or without addition of 0.5% yeast extract, and 27.8 g/L with addition of LB broth ingredients after 96h. P2 produced 24.5, 26.9, and 28.0 g ethanol/L in molasses diluted 10-fold in vinasse, vinasse with 0.5% added yeast extract and with LB broth ingredients, respectively

  9. Kým je či není Michal Ajvaz? aneb O nálepkách. Úvaha o studii Veroniky Košnarové "Masky touhy"

    Czech Academy of Sciences Publication Activity Database

    Janoušek, Pavel

    2013-01-01

    Roč. 61, č. 1 (2013), s. 131-133. ISSN 0009-0468 Institutional support: RVO:68378068 Keywords : Czech literature * Ajvaz, Michal * postmodernism * Košnarová, Veronika Subject RIV: AJ - Letters, Mass-media, Audiovision

  10. Utjecaj nasljeđa i okoliša na vršnu koštanu gustoću: pregled istraživanja u Hrvatskoj

    OpenAIRE

    Cvijetić-Avdagić, Selma; Colić-Barić, Irena; Keser, Irena; Rumbak, Ivana; Šatalić, Zvonimir

    2012-01-01

    Vršna koštana gustoća je jedna od najvažnijih pretpostavki za nastanak osteoporoze. Poznati su rizični faktori za vršnu koštanu gustoću, ali vrijeme njezinog postizanja nije u potpunosti defi nirano. S obzirom na to da se dijagnoza osteoporoze i osteopenije temelji na usporedbi mineralne gustoće kosti (BMD) pojedinca s prosječnom vršnom koštanom gustoćom u mladoj, odrasloj populaciji (T vrijednost), vrlo je značajno da svaka zemlja utvrdi vrijednosti vršne koštane gustoće za svoju populaciju....

  11. Bilateral male breast cancer with male potential hypogonadism

    OpenAIRE

    Kurokawa Yasushi; Morimoto Tadaoki; Hirose Toshiyuki; Bando Yoshimi; Sasa Mitsunori; Hirose Yukiko; Nagao Taeko; Tangoku Akira

    2007-01-01

    Abstract Background Male breast cancer is a comparatively rare disease, and simultaneous bilateral male breast cancer is considered to be an extremely rare event. Risk factors are said to be genetic factors and hormonal abnormalities due to obesity or testicular diseases. Case presentation The patient was a 47-year-old Japanese male. His family had no history of female breast cancer. This patient also had hypospadias and hormonal examination indicated the presence of primary testicular potent...

  12. Cuts in energy and operating cost with the Swiss system &apos;Energie in ARA&apos; - practical experience in Germany; Energie- und Betriebskosteneinsparungen nach dem schweizerischen System &apos;&apos;Energie in ARA&apos;&apos; - Praxiserfahrungen in Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Christmann, B. [UmBAUwelt Partnerschaft Architekten und Ingenieure, Riedstadt (Germany)

    1999-07-01

    German sewage treatment plants, too, have potential for saving energy cost and cutting down on their operating expenditure. Following the systematy developed by the &apos;Energie in ARA&apos; concept, this potential can be harnessed. (orig.) [German] Potential fuer Energiekosteneinsparungen und dadurch initiierte Betriebskosteneinsparungen ist auch bei deutschen Klaeranlagen vorhanden. Die Systematik &apos;Energie in ARA&apos; kann fuer die Erschliessung der Einsparpotentiale verwendet werden. (orig.)

  13. ApoE mimetic peptide decreases Aβ production in vitro and in vivo

    Directory of Open Access Journals (Sweden)

    Pak Daniel TS

    2010-04-01

    Full Text Available Abstract Background Apolipoprotein E (apoE is postulated to affect brain Aβ levels through multiple mechanisms--by altering amyloid precursor protein (APP processing, Aβ degradation, and Aβ clearance. We previously showed that an apoE-derived peptide containing a double repeat of the receptor-binding region was similarly effective in increasing APP processing in vivo. Here, we further examined whether peptides containing tandem repeats of the apoE receptor-binding region (amino acids 141-149 affected APP trafficking, APP processing, and Aβ production. Results We found that peptides containing a double or triple tandem repeat of the apoE receptor-binding region, LRKLRKRLL, increased cell surface APP and decreased Aβ levels in PS1-overexpressing PS70 cells and in primary neurons. This effect was potentiated by a sequential increase in the number of apoE receptor-binding domain repeats (trimer > dimer > monomer. We previously showed that the apoE dimer increased APP CTF in vivo; to determine whether the dimer also affected secreted APP or Aβ levels, we performed a single hippocampal injection of the apoE dimer in wild-type mice and analyzed its effect on APP processing. We found increased sAPPα and decreased Aβ levels at 24 hrs after treatment, suggesting that the apoE dimer may increase α-secretase cleavage. Conclusions These data suggest that small peptides consisting of tandem repeats of the apoE receptor-binding region are sufficient to alter APP trafficking and processing. The potency of these peptides increased with increasing repeats of the receptor binding domain of apoE. In addition, in vivo administration of the apoE peptide (dimer increased sAPPα and decreased Aβ levels in wild-type mice. Overall, these findings contribute to our understanding of the effects of apoE on APP processing and Aβ production both in vitro and in vivo.

  14. OPEC&apos;s strategies

    Energy Technology Data Exchange (ETDEWEB)

    Wirl, Franz [Vienna Univ. (Austria). Faculty of Business, Economics and Statistics

    2012-09-15

    This paper investigates rationale explanations of OPEC&apos;s strategies. Accounting for market characteristics in particular the sluggishness of demand and supply allows to explain price jumps as rational OPEC strategies from a narrow economic perspective (up and down) as well as from political objectives (at least up) due to the political payoff from standing up against the &apos;West&apos;. Although the temptation to accrue this political payoff was and remains high, the narrow economic profit motive coupled with an imperfect cooperation among OPEC members explains past price volatility and high prices much better than the usual reference to political events. A more specific prediction is that OPEC will switch back to setting prices since the current quantity strategy encourages oil importing countries to appropriate rents in particular in connection with the need to mitigate global warming. (orig.)

  15. Vertigo Imaging; Clinical Radiology&apos;

    Directory of Open Access Journals (Sweden)

    Jalal Jalal Shokouhi

    2009-01-01

    Full Text Available   "n- Dizziness that patients complain from are rotational vertigo, sense of instability, ataxia of gait, disturbance of vision, loss of contact with surroundings, nausea, loss of memory, loss of confidence, epileptic convulsion and dizziness that is considered by medical staff are: "n1- Vertigo as a sense of feeling the environment moving when it does not persist in all positions, aggravated by head movement. "n2- Disequilibrium as a feeling of unsteadiness or insecurity without rotation, standing and walking are difficult. "n3- Light headedness as swimming, floating, giddy or swaying sensation in the head or in the room. "nTaking the history from a vertigo patient:* "n            What the patient means by vertigo?- "n- Time of onset "n-Temporal pattern "n-Associated signs and symptoms &apos;&apos; tinnitus, hearing loss, headache, double vision, numbness and difficulty in swallowing &apos;&apos;. "n- Precipitating, aggravating and relieving factors. "n- If episodic: sequence of events, activity at onset, aura, severity and amnesia. "n*Examination of the vertigo patient checking: "nSpontaneous nystagmus, positional nystagmus, optokinetic nystagmus, posture and balance control like romberg&apos;s test, blind walking, untenberger and barany&apos;s test, stimulation of labyrinth, caloric test &apos;&apos; cold, warm water &apos;&apos; and the rotational test. "nEtiology : "n*Spontaneous nystagmus: "nPosture and balance control is positive with nausea , vomiting , sweating and anxiety : harmonic vestibular sy with loss of hearing , tinnitus , vestibular neuronitis , meniere disease and with otologic origin and dysharmmonic vestibular sy , with numbness , double vision , dysarthria in brain stem infarct and with a neurological origin. "nNonspontaneous nystagmus :Posture and balance negative with nausea, vomiting in GI disorders and internal medicine , sweating and trachycardia by chest pain in angina , M.I &apos;&apos; cardiology &apos;&apos

  16. &apos;Blueprint&apos; your pulverizer for improved performance

    Energy Technology Data Exchange (ETDEWEB)

    Storm, R.F. [Storm Technologies Inc. (United States)

    2009-03-15

    Pulverizer throughput is determined by the coal fineness desired for a given coal. However, compromising on coal fineness when your pulverizer isn&apos;t up to scratch can increase NOx and cause many furnace problems. Your least costly option for increasing pulverizer capacity is to pay careful attention to key dimensions and critical tolerances during your next overhaul. 11 figs.

  17. Crisis - Weisskopf&apos;s view

    International Nuclear Information System (INIS)

    &apos;We are facing a crisis, not only in particle physics but in the whole of fundamental science&apos;, said Victor Weisskopf, doyen of quantum physics, during his traditional summer CERN stopover. &apos;Basic science - science for its own sake - and especially high energy physics, is really in danger.&apos; As well as explaining how this has come about, the former CERN Director General (1961-5) proposed action to reverse the trend. Rather than dividing science into the conventional &apos;big&apos; and &apos;small&apos; camps, he slices across another axis. On one hand there is obviously applicable &apos;terrestrial science&apos; - biology, medicine, solid state, much of the nuclear sector, nonlinear behaviour, chaos,....all directly connected with processes that happen on Earth. On the other there is &apos;cosmic science&apos; - astronomy, astrophysics, particle physics and some of the nuclear sector - addressing deeper issues, not attainable naturally on this planet at all, and where applications are less immediately obvious. (This classification is not completely watertight - even cosmic science can, and does, foster immediate spinoff, Weisskopf points out, citing Georges Charpak&apos;s detector work.) Tracing the evolution of science in this century, Weisskopf sees the rapid evolution of American influence in the 1930s as a turning point. Before then, the United States had not been in the front line, and it had been important for US researchers to spend some time in Europe

  18. Proliferation Resistance and Safeguards by Design: The Safeguardability Assessment Tool Provided by the INPRO Collaborative Project &apos;'INPRO'&apos; (Proliferation Resistance and Safeguardability Assessment)

    International Nuclear Information System (INIS)

    Since the INPRO Collaborative Project on Proliferation Resistance and Safeguardability Assessment Tools (PROSA) was launched in 2011, Member State experts have worked with the INPRO Section and the IAEA Department of Safeguards to develop a revised methodology for self-assessment of sustainability in the area of proliferation resistance of a nuclear energy system (NES). With the common understanding that there is &apos;&apos;no proliferation resistance without safeguards&apos;&apos; the revised approach emphasizes the evaluation of a new &apos;User Requirement&apos; for &apos;'safeguardability'&apos;, that combines metrics of effective and efficient implementation of IAEA Safeguards including &apos;'Safeguards-by-Design'&apos; principles. The assessment with safeguardability as the key issue has been devised as a linear process evaluating the NES against a &apos;&apos;Basic Principle&apos;&apos; in the area of proliferation resistance, answering fundamental questions related to safeguards: 1) Do a State&apos;s legal commitments, policies and practices provide credible assurance of the exclusively peaceful use of the NES, including a legal basis for verification activities by the IAEA? 2) Does design and operation of the NES facilitate the effective and efficient implementation of IAEA safeguards? To answer those questions, a questionnaire approach has been developed that clearly identifies gaps and weaknesses. Gaps include prospects for improvements and needs for research and development. In this context, the PROSA approach assesses the safeguardability of a NES using a layered &apos;&apos;Evaluation Questionnaire&apos;&apos; that defines Evaluation Parameters (EP), EP-related questions, Illustrative Tests and Screening Questions to present and structure the evidence of findings. An integral part of the assessment process is Safeguards-by-Design, the identification of potential diversion, misuse and concealment strategies (coarse diversion path

  19. Effects of nocturnal aircraft noise on sleep: results from the &apos;&apos;quiet air traffic&apos;&apos; project; Wirkungen des Nachtfluglaerms auf den Schlaf: Ergebnisse aus dem Projekt &apos;&apos;Leiser Flugverkehr&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Samel, A.; Basner, M.; Maass, H.; Mueller, U.; Quehl, J.; Wenzel, J. [Deutsches Zentrum fuer Luft- und Raumfahrt (DLR) in der Helmholtz-Gemeinschaft (HGF), Inst. fuer Luft- und Raumfahrtmedizin, Koeln (Germany)

    2005-07-01

    In 192 sleep-healthy subjects (18 to 65 y) effects of nocturnal aircraft noise on sleep, stress, performance and subjective factors were investigated in 2240 nights under laboratory and field conditions. In the sleep lab, 112 volunteers were subjected to aircraft noise events by varying numbers and noise levels during 9 nights within a period of 13 nights. 16 further subjects served as control group (i.e. without any noise). 64 subjects were studied in the vicinity of Cologne-Bonn airport during 9 nights. Polysomnographical and acoustical recordings, determination of excretion rates of stress hormones from night urines, performance tests and questionnaires were conducted during all days for the assessment of nocturnal aircraft noise effects. By simultaneous recording of electrophysiological and acoustical data the probability of noise induced awakenings was estimated. Performance and most of psychological parameters did not show significant dose-effect relationships, whereas annoyance did. Epinephrine and norepinephrine did not change under aircraft noise, cortisol did change only in the lab. In the lab, a comparison between all noisy nights and noise-free baseline nights exhibited a non-significant 2-min. reduction of sleep and a 4-min. decrease of slow-wave sleep. In the field, awakenings caused by aircraft noise were detected above a threshold of 33 dB(A) &apos;&apos;at the sleeper&apos;s ear&apos;&apos;. All effects were much less pronounced in the field than in the lab. For the first time, precise dose-effect curves between maximum aircraft noise event levels and electrophysiologically detectable awakenings, and a threshold were empirically established. The results of these studies broadens the knowledge on aircraft noise induced sleep disturbances and immediate consequences for the next day. (orig.)

  20. The effect of dietary antioxidant on the COPD risk: the community-based KoGES (Ansan–Anseong cohort

    Directory of Open Access Journals (Sweden)

    Joshi P

    2015-10-01

    Full Text Available Pankaj Joshi,1,2 Woo Jin Kim,3,4 Sang-Ah Lee1–3 1Department of Preventive Medicine, 2BIT Medical Convergence Graduate Program, 3Department of Internal Medicine, 4Environmental Health Center, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do, South Korea Background: Dietary antioxidants have been suggested to have protective role against chronic obstructive pulmonary disease (COPD, but few prospective studies examined this relationship. The prospective study was conducted to evaluate the effect of dietary antioxidants on COPD risk and lung function in the Korean population.Methods: The data were collected from the community-based Korean Genome Epidemiology Study (KoGES cohort. To diagnose COPD, forced expiratory volume (FEV1 and forced vital capacity (FVC were measured by spirometry. The dietary intake of antioxidant vitamins was estimated from validated Food-Frequency Questionnaire. For the analysis, 325 COPD patients and 6,781 at risk subjects were selected from the cohort of 10,038 subjects. Multiple logistic regression models were used to examine the odds ratio (OR after adjusting for age, sex, marital status, income, history of asthma, history of tuberculosis, and smoking.Results: The risk of COPD was positively associated with aging, low education, low household income, lower body mass index, and cigarette smoking. The risk of COPD decreased with increase in the dietary vitamin C (ORQ1 vs Q5=0.66, Ptrend=0.03 and vitamin E (ORQ1 vs Q5=0.56, Ptrend=0.05 intake, predominantly, in men (Ptrend=0.01 and 0.05 for vitamins C and E, respectively. In addition, the lung function was significantly improved with increase in vitamins C (FEV1, P=0.04; FVC, P=0.03 and E (FEV1, P=0.03; FVC, P=0.04 intake. No statistically significant interactions were observed between smoking and vitamin C or E intake in relation to COPD risk among men.Conclusion: Our results suggest the independent beneficial effect of antioxidants, particularly

  1. THE TYPOLOGY OF THE AGRICULTURAL LANDSCAPE OF DUBROVAČKO PRIMORJE AS A BASIS FOR DIRECTING DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Ines Hrdalo

    2008-07-01

    Full Text Available Abandonment of rural areas in Dubrovačko Primorje in the last 50 years resulted with changes of its spatial characteristics and identity. This process defi ned this place as a virtually derelict area. The main goal of this work is to determine landscape types based upon survey and spatial analyses. They can be helpful in a process of determination of spatial qualities. Landscape division was made according to the natural and anthropogenic features of this area. Therefore, landscape was divided on natural (coast, karst terrain and landscapes of the macchia and cultural (settlement and agriculture landscapes. Working methods consisted of several research stages. The fi rst stage comprised a review of relevant literature concerning natural and sociological features of the explored area. Working methods of prof. dr. Marušič were inspiration for evolvement of this research [16]. The next stage of research was the fi eld work by means of observation method which resulted in detailed photo documentation, showing different types of the agricultural landscapes. Indoor work consisted of the orthophoto production, which was a base for further exploration. Consequently, detailed map of the land use, as well as an agricultural map of the area was made according to the structural husbandry character. Digital mapping of the thematical maps in GIS – Arc View software program, produced a database of social and natural elements of the area. Overlapping of all these maps helped in determination of causal processes. Comparison of these outcomes with terrain photo documentation led to the research results and fi nal conclusions. This research showed interesting structural features of agricultural landscapes. Its division was made according to its form which emerged from the land use and its natural character. Consequently, agricultural landscapes are divided into fi elds (with regular parcels and those with irregular land division, dry stone walls with organic

  2. DESKRIPTIVNI PROFIL TJELESNE STRUKTURE VRHUNSKIH RVAČA GRČKO-RIMSKOG STILA DEFINISAN METODOM MULTIKANALNE BIOELEKTRIČNE IMPEDANCE

    Directory of Open Access Journals (Sweden)

    Goran Kasum

    2012-12-01

    Full Text Available Zbog specifičnosti sporta i težinskih kategorija rvači se odlikuju i specifičnim morfološkim karakteristikama. Sa razvojem novih tehnologija mjerenja stvaraju se i nove mogućnosti za usavršavanje načina dobijanja novih informacija značajnih za sistem sporta. Jedna od novih tehnologija, koja se primenjuje u prostoru mjerenja strukture tjelesnog sastava je metod bioimpedance, a najnovije generacije koriste varijantu multikanalne bioelektrične bioimpedance. Cilj ovog rada je da definiše morfološki model vrhunskih rvača seniorskog uzrasta, primjenom tehnološki najnovije metode, čime će se izvršiti revalidacija postojećih saznanja o datom prostoru. Uzorak ispitanika je bio sastavljen od 22 ispitanika muškog pola, rvača iz discipline grčko-rimski, takmičara vrhunskog seniorskog nivoa iz četiri zemlje: Srbija (n = 10, Hrvatska (n = 9, Crna Gora (n = 2 i Grčka (n = 1. Mjerenje tjelesnog sastava je izvršeno metodom multikanalne bioelektrične impedance pomoću profesionalnog aparata najnovije generacije - InBody 720 Tetrapolar 8-Point Tactile Electrode System (Biospace, Co., Ltd. Najvažniji rezultat ovog istraživanja je definisanje generičkog (opšteg četvorodimenzionalnog modela (4D model sastava tijela u funkciji kvalitetnih rvača međunarodne klase koji ima sljedeće karakteristike (u odnosu na prosječnu tjelesnu masu rvača iz uzorka – 81,95 kg: sadržaj vode iznosi 55,08 L ili 67,24%, količina proteina iznosi 15,00 kg ili 18,33 %, masa minerala iznosi 4,98 kg ili 5,97% i masa masti iznosi 6,99 kg ili 8,49%.

  3. Upgrading of the Ukrainian NPPs and the &apos;&apos;2+2&apos;&apos; approach applied for the licensing of the major modifications

    Energy Technology Data Exchange (ETDEWEB)

    Gorbatchev, A. [Institut de Radioprotection et de Surete Nucleaire, IRSN/DES/SERS, 92 - Fontenay aux Roses (France); Goetsch, D. [Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) mbH, Garching (Germany); Redko, V. [Ukrainian National Regulatory Authorities (Ukraine); Madonna, A. [National Agency for Environmental Protection (ANPA), Rome (Italy)

    2003-01-01

    Many of the planned upgrading measures of Ukrainian VVER plants and of the unique Armenian power plant (Medzanor) are financed by the European Union (EU) through the TACIS program. The &apos;&apos;2+2&apos;&apos; approach implies a deep collaboration between Ukrainian or Armenian regulatory authorities, local operating organizations and EU organizations. This approach allows: - a smooth adaptation of western technologies to VVERs, - a comprehensive checking of Ukrainian, Armenian and western regulatory requirements, and - the transfer of know-how to the Ukrainian and Armenian organizations. This report presents the principles applied for &apos;&apos;2+2&apos;&apos; approach as well as a summary of the main recommendations given in the framework of the licensing process.

  4. The effects of apoA-I/C-III/A-IV, apoE and apoB polymorphisms on carotid artery intima-media thickness.

    Science.gov (United States)

    Nieminen, Tuomo; Kähönen, Mika; Lehtimäki, Terho

    2006-03-01

    Different apolipoprotein combinations explain most of the functional differences between plasma lipoproteins. This emphasizes the pivotal role of apolipoproteins in the homeostasis and physiological control of lipid metabolism. Genetic polymorphisms of apolipoprotein (apo)A-I/C-III/A-IV, apoE and apoB have been suggested to modulate plasma lipid levels as well as the risk of coronary artery disease and stroke. Carotid artery intima-media thickness has been shown to represent preclinical atherosclerosis and has, therefore, been used as a surrogate in quantifying the early stages of atherosclerosis. The effects of the polymorphisms in apoA-I/C-III/A-IV and apoB on carotid intima-media thickness are poorly known. The corresponding influence of apoE polymorphisms has been studied more extensively, but the results are not yet conclusive. In this review, these results are presented in detail and the potential reasons and mechanisms for the discrepancies are discussed. PMID:19804074

  5. APATHY AND APOE4 ARE ASSOCIATED WITH REDUCED BDNF LEVELS IN ALZHEIMER’S DISEASE

    Science.gov (United States)

    Álvarez, Antón; Aleixandre, Manuel; Linares, Carlos; Masliah, Eliezer; Moessler, Herbert

    2016-01-01

    Reduced brain-derived neurotrophic factor (BDNF) signaling is considered as a pathogenic event in early Alzheimer’s disease (AD), but the influence of apathy and apolipoprotein E epsilon-4 allele (APOE4) on serum BDNF values was not previously investigated in AD. We evaluated serum BDNF levels in AD, amnestic mild cognitive impairment (MCI) and control subjects. Baseline BDNF levels were similar in AD, MCI and controls. AD patients having apathy showed lower BDNF values than patients without apathy (p<0.05). After correction for the influence of apathy, APOE4 carriers showed lower BDNF levels (p<0.01) and MMSE scores (p<0.01) than non-APOE4 carriers in the subgroup of AD females, but not in males. Significant (p<0.05) positive correlations between BDNF values and MMSE scores were only observed in subgroups of AD males and of AD patients without apathy. These results are showing the association of apathy and APOE4 with reduced serum BDNF levels in AD, and are suggesting that BDNF reductions might contribute to the worse cognitive performance exhibited by AD apathetic patients and female APOE4 carriers. PMID:25024337

  6. Parents’ Attitudes towards Adolescent Boy&apos;s Reproductive Health Needs and Practice in Tehran

    Directory of Open Access Journals (Sweden)

    Farideh K Abadi Farahani

    2007-05-01

    Full Text Available Objective: Parents are believed to be among the most influential adults who have a deterministic role in the success of interventional programs on adolescents&apos; reproductive health. The aim of this study is to describe parents&apos; perceptions and attitudes towards adolescent reproductive needs, experiences and associated factors. Method: A population-based study of 539 parents of adolescent boys, aged 15-18 in Tehran was conducted using a self-administered questionnaire. bivariate and multivariate analyses were performed to identify the factors associated with parents&apos; attitudes and their reports of adolescent heterosexual relationships. Results: Higher education, higher income, access to satellite programs and internet were associated with a liberal attitude among parents. Some demographic factors including adolescents&apos; age, lack of adolescents&apos; endorsement to religion, access to satellite programs, parents&apos; drinking, and various family factors such as poor parent-adolescent relationship, conflict, parental low valuation on education, parents&apos; low endorsement to morals, difficult parent-adolescent communication on important issues and finally easy communication about sex, were all among the factors associated with more frequent reports of having a girlfriend over the last year for the adolescent males. Parents&apos; reports on their adolescents&apos; sexual relationships with the opposite sex highlighted a significant gap with the figure reported for the adolescents aged 15-18 in a preceding study in 2002(3% vs. 28%. Conclusion: Parents should be advised to build a good relationship with teens, to maintain a close parent-teen communication, and to discuss morals and values with teens .

  7. Final Report on Project 01-ERD-017 &apos;&apos;Smart Nanostructures From Computer Simulations&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Grossman, J C; Williamson, A J

    2004-02-13

    This project had two main objectives. The first major goal was to develop new, powerful computational simulation capabilities. It was important that these tools have the combination of the accuracy needed to describe the quantum mechanical nature of nanoscale systems and the efficiency required to be applied to realistic, experimentally derived materials. The second major goal was to apply these computational methods to calculate and predict the properties of quantum dots--initially composed of silicon, but then of other elements--which could be used to build novel nanotechnology devices. The driving factor of our purpose has been that, through the development and successful application of these tools, we would generate a new capability at LLNL that could be used to make nanostructured materials &apos;'smarter'&apos;, e.g., by selectively predicting how to engineering specific, desired properties. To carry out the necessary work to successfully complete this project and deliver on our goals, we established a two-pronged effort from the beginning: (1) to work on developing new, more efficient algorithms and quantum simulation tools, and (2) to solve problems and make predictions regarding properties of quantum dots which were being studied experimentally here at Livermore.

  8. Comment on &apos;&apos;Functional integral for Weyl fermions and the effective action&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Banerjee, R.; Banerjee, H.

    1989-02-15

    Baaklini&apos;s method of obtaining the effective action for Weyl fermions is shown to yield either a gauge-invariant or a gauge-variant form depending on the specific definition employed in the analysis. The structures of the effective action proposed by Baaklini are found to correspond to the standard expressions.

  9. Imaging of bridging vein thrombosis in infants with abusive head trauma: the &apos;&apos;Tadpole Sign&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Hahnemann, Maria L.; Kinner, Sonja; Schweiger, Bernd [University Hospital Essen, Institute of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); Bajanowski, Thomas [University Hospital Essen, Institute of Legal Medicine, Essen (Germany); Karger, Bernd; Pfeiffer, Heidi; Wittschieber, Daniel [University Hospital Muenster, Institute of Legal Medicine, Muenster (Germany)

    2014-10-03

    Abusive head trauma (AHT) in infants is usually diagnosed using a multi-disciplinary approach by investigating the circumstances and identifying morphological indicators, for example, subdural hematomas (SDHs), subdural hygromas (SDHys), retinal haemorrhages and encephalopathy. The present morphological study investigates the incidence, radiological characteristics and non-radiological co-factors of bridging vein thrombosis (BVT) in infants with AHT. From 2002 to 2013, computed tomography (CT) and magnetic resonance imaging (MRI) material of 628 infants aged 0-2 years were analysed retrospectively. If available, medicolegal expert opinions were additionally considered. Cases with SDHs and/or SDHys were identified and systematically evaluated as to the presence and characteristics of BVT. SDHs and/or SDHys were present in 29 of the 81 cases exhibiting morphological abnormalities in the initial CT. Among these, 11 cases (40 %) had BVT (mean age = 5.0 months). BVT could be best depicted in the T1-weighted spin echo and T2*/susceptibility-weighted MRI. In one case, BVT could be depicted indirectly using time-of-flight MR venography. The predominant (73 %) BVT shape was found to be tadpole-like (&apos;&apos;Tadpole Sign&apos;&apos;). In the absence of appropriate accidental trauma, BVT appears to be a strong indicator of AHT. Therefore, the BVT/Tadpole Sign represents compelling cause to search for other signs of AHT. (orig.)

  10. Proposal of a simple screening method for a rapid preliminary evaluation of &apos;&apos;heavy metals&apos;&apos; mobility in soils of contaminated sites

    Energy Technology Data Exchange (ETDEWEB)

    Pinto, Valentina; Chiusolo, Francesca; Cremisini, Carlo [ENEA - Italian Agency for New Technologies, Energy and Environment, Rome (Italy). Section PROTCHIM

    2010-09-15

    Risks associated to &apos;&apos;heavy metals&apos;&apos; (HM) soil contamination depend not only on their total content but, mostly, on their mobility. Many extraction procedures have been developed to evaluate HM mobility in contaminated soils, but they are generally time consuming (especially the sequential extraction procedures (SEPs)) and consequently applicable on a limited number of samples. For this reason, a simple screening method, applicable even &apos;&apos;in field&apos;&apos;, has been proposed in order to obtain a rapid evaluation of HM mobility in polluted soils, mainly focused on the fraction associated to Fe and Mn oxide/hydroxides. A buffer solution of trisodium citrate and hydroxylamine hydrochloride was used as extractant for a single-step leaching test. The choice of this buffered solution was strictly related to the possibility of directly determining, via titration with dithizone (DZ), the content of Zn, Cu, Pb and Cd, which are among the most representative contaminants in highly mineralised soils. Moreover, the extraction solution is similar, aside from for the pH value, which is the one used in the BCR SEP second step. The analysis of bivalents ions through DZ titration was exploited in order to further simplify and quicken the whole procedure. The proposed method generically measures, in few minutes, the concentration of total extractable &apos;&apos;heavy metals&apos;&apos; expressed as molL{sup -1} without distinguishing between elements. The proposed screening method has been developed and applied on soil samples collected from rural, urban and mining areas, representing different situation of soil contamination. Results were compared with data obtained from the BCR procedure. The screening method demonstrated to be a reliable tool for a rapid evaluation of metals mobility. Therefore, it could be very useful, even &apos;&apos;in field&apos;&apos;, both to guide the sampling activity on site and to monitor the efficacy of the subsequent

  11. Inorganic profile of some Brazilian medicinal plants obtained from ethanolic extract and &apos;&apos;in natura&apos;&apos; samples

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, M.O.M.; de Sousa, P.T.; Salvador, V.L.R.; Sato, I.M.

    2004-10-03

    The Anadenathera macrocarpa, Schinus molle, Hymenaea courbaril, Cariniana legalis, Solidago microglossa and Stryphnodendron barbatiman, were collected &apos;&apos;in natura&apos;&apos; samples (leaves, flowers, barks and seeds) from different commercial suppliers. The pharmaco-active compounds in ethanolic extracts had been made by the Mato Grosso Federal University (UFMT). The energy-dispersive x-ray fluorescence (ED-XRF) spectrometry was used for the elemental analysis in different parts of the plants and respective ethanolic extracts. The Ca, Cl, Cu, Fe, K, Mg, Mn, Na, Ni, P, Rb, S, Sr and Zn concentrations were determined by the fundamental parameters method. Some specimens showed a similar inorganic profile for &apos;&apos;in natura&apos;&apos; and ethanolic extract samples and some ones showed a distinct inorganic profile. For example, the Anadenathera macrocarpa showed a similar concentration in Mg, P, Cu, Zn and Rb elements in &apos;&apos;in natura&apos;&apos; and ethanolic extract samples; however very different concentration in Na, S, Cl, K , Ca, Mn, Fe and Sr was observed in distinctive samples. The Solidago microglossa showed the K, Ca, Cl, S, Mg, P and Fe elements as major constituents in both samples, suggesting that the extraction process did not affect in a considerable way the &apos;&apos;in natura&apos;&apos; inorganic composition. The elemental composition of the different parts of the plants (leaves, flowers, barks and seeds) has been also determined. For example, the Schinus molle specimen showed P, K, Cl and Ca elements as major constituents in the seeds, Mg, K and Sr in the barks and Mg, S, Cl and Mn in the leaves, demonstrating a differentiated elementary distribution. These inorganic profiles will contribute to evaluate the quality control of the Brazilian herbaceous trade and also will assist to identify which parts of the medicinal plants has greater therapeutic effect.

  12. Solar tank. &apos;Solar ship&apos; and solar development project at Freiburg; Sonne im Tank. &apos;Sonnenschiff&apos; und Solarsiedlung in Freiburg

    Energy Technology Data Exchange (ETDEWEB)

    Alle, N.

    2007-05-15

    In the &apos;Vauban&apos; district of the German city of Freiburg, 59 plusenergy terrace houses and one block of offices and shops were constructed during the past five years. The latter is named &apos;solar ship&apos; and has nine penthouses on its roof which generate more power than they consume. The building is 125 m long and is both a building and a power station. (orig.)

  13. WORKSHOP: Let&apos;s twist again..

    International Nuclear Information System (INIS)

    In the quantum chromodynamics (QCD) candidate theory of interquark forces, calculations involve summing the effects from many different possible quark/gluon interactions. In addition to the &apos;leading term&apos; frequently used as the basis for QCD calculations, additional contributions — so-called &apos;higher twists&apos; — are modulated by powers of kinematical factors. An illuminating international workshop to discuss higher twist QCD was held at the College de France, Paris, from 21-23 September

  14. Conference: &apos;Heating with Wood&apos;. An alternative to fossil fuels? Status and perspectives. Documentation; Tagung: &apos;Heizen mit Holz&apos;. Eine Alternative zur fossilen Energie? Stand der Technik und neue Perspektiven. Dokumentation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    Main topics of the meeting &apos;&apos;Heating with wood&apos;&apos; were: resource assessment, economical aspects, logistics, cogeneration, district heating, plantation and harvesting of fast growing trees, new heating systems.(uke)

  15. Children&apos;s Talking and Listening within the Classroom: Teachers&apos; Insights

    Science.gov (United States)

    Bosacki, Sandra; Rose-Krasnor, Linda; Coplan, Robert J.

    2014-01-01

    Research suggests that social communication (verbal and non-verbal) plays a key role in students&apos; and teachers&apos; elementary-school experiences. Within the framework of sociocognitive developmental theory, this qualitative study investigates teachers&apos; experiences and perceptions of children&apos;s talking and listening habits within…

  16. Resource consumption of Germany - indicators and definitions. Development of a glossary on the concept of &apos;'resources'&apos; and calculation of missing characteristic data of resources consumption for further political analysis; Ressourcenverbrauch von Deutschland - aktuelle Kennzahlen und Begriffsbestimmungen. Erstellung eines Glossars zum &apos;'Ressourcenbegriff'&apos; und Berechnung von fehlenden Kennzahlen des Ressourcenverbrauchs fuer die weitere politische Analyse

    Energy Technology Data Exchange (ETDEWEB)

    Schuetz, Helmut; Bringezu, Stefan [Wuppertal Institut fuer Klima, Umwelt, Energie GmbH, Wuppertal (Germany). Forschungsgruppe 3: Stoffstroeme und Ressourcenmanagement

    2008-02-15

    The goals of the reported study are: - to prepare a glossary on the term &apos;'Resources'&apos; in order to support communication based on a harmonised resource term and associated terms and - to provide key data on resource use in Germany in time series since 1991 up to the most recent year for which data were available (2004 in general), and to attribute results to the resource terms. Results achieved are presented and discussed below by the following sections: Provision of a glossary on the term &apos;'resource'&apos;, use of the term &apos;'resource'&apos; at different levels, and provision of data and derived indicators for resource consumption in time series. First, a list of the relevant publications in the topic field &apos;'resources'&apos; was provided and co-ordinated with the client. This publication list is given in the annex to this report. On basis of national and international sources a glossary was provided which clearly describes and comments the resource term, its sub-terms and associated terms. This glossary is in the annex to this report. (orig.)

  17. Autogenous osteochondral &apos;'plug'&apos; transfer for the treatment of focal chondral defects: postoperative MR appearance with clinical correlation

    Energy Technology Data Exchange (ETDEWEB)

    Sanders, T.G. [Dept. of Radiology, Univ. of Texas, San Antonio (United States); Dept. of Radiology, Wilford Hall Medical Center, Lackland AFB, Texas (United States); Dept. of Radiology, Lackland AFB, TX (United States); Mentzer, K.D. [Dept. of Orthopaedics, Wilford Hall USAF Medical Center, Lackland AFB, TX (United States); Miller, M.D. [Dept. of Orthopaedic Surgery, Univ. of Virginia, Charlottesville (United States); Morrison, W.B. [Thomas Jefferson Univ., Philadelphia, PA (United States). Dept. of Radiology; Campbell, S.E. [Dept. of Radiology, Wilford Hall USAF Medical Center, Lackland AFB, TX (United States); Penrod, B.J. [Musculoskeletal Radiology, Brooke Army Medical Center, San Antonio, TX (United States)

    2001-10-01

    Objective: To describe the MR appearance following autogenous osteochondral &apos;'plug'&apos; transfer for the treatment of focal chondral defects of the knee. Design and patients: Twenty-nine 1.5-T MR knee studies including dynamic gadolinium enhancement were performed on 21 patients following autogenous osteochondral &apos;'plug'&apos; transfer. Three musculoskeletal radiologists retrospectively reviewed images to evaluate graft and donor site appearance and MR findings were correlated with clinical outcomes. Results: MR images demonstrated graft protuberance (n=12/21; range 1-2 mm), depression (n=2/21; range 1 mm), and surface incongruity: mild (n=17/21), moderate (n=2/21), marked (n=1/21). The T2 signal of graft cartilage was similar to that of adjacent cartilage in 25 of 29 examinations, and increased in four. Graft cartilage thickness relative to adjacent cartilage was <50% in six patients, 50-100% in 15. Graft enhancement in bone was absent at 2 weeks, but present at between 4 and 6 weeks following surgery. All patients had clinical follow-up examinations and knee outcome survey scores were obtained in 15 patients with follow-up greater than 3 months after surgery. All patients demonstrated the expected short-term progressive clinical improvement. Conclusion: MR images reveal a wide range of appearances following osteochondral &apos;'plug'&apos; transfer. Minor variations in graft orientation and surface congruity do not result in adverse clinical outcome in the short term. (orig.)

  18. Solar passive building &apos;Working and Living&apos; in Freiburg, Vauban. Final report; Solar-Passivhaus &apos;Wohnen und Arbeiten&apos;, Freiburg, Vauban. Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Wittwer, V.; Voss, K.

    2001-03-30

    Objective of the project: The apartment house called &apos;&apos;living and working&apos;&apos; in the conversion area &apos;'Vauban'&apos; in Freiburg was built with the goal to achieve CO2 -savings of 80% compared to todays standard new buildings regarding heating, warm water and electricity (incl. household appliances). The additional investment costs should not exceed 300 DM per square meter. Presentation of the working steps of the methods applied: Using the subsidies detailed solutions and calculations regarding rentability and costs could be obtained during the planning process. The cost-yield ratio (DM applied/saved primary energy) was determined for all measures planned.This instrument proved to be very useful in making decisions for selecting the measures to be taken. [German] Zielsetzung und Anlass des Vorhabens: Das Mehrfamilienhaus &apos;Wohnen and Arbeiten&apos; im Freiburger Konversionsgebiet &apos;Vauban&apos; entstand mit der Zielrichtung in den Bereichen Heizung, Warmwasser und Elektrizitaet (ink. Haushaltsgeraete) eine CO{sub 2}-Einsparung von 80% gegenueber dem heute ueblichen Neubaustandard zu erreichen. Dabei sollten die investiven Mehrkosten pro Quadratmeter Wohnflaeche nicht mehr als 300 DM betragen. Darstellung der Arbeitsschritte und der angewandten Methoden: Mit Hilfe der Foerdergelder konnten bereits waehrend des Planungsprozesses Detailloesungen, sowie ausfuehrliche Wirtschaftlichkeits- und Kostenbetrachtungen durchgefuehrt werden. Fuer alle geplanten Massnahmen wurde das Kosten-Nutzenverhaeltnis (eingesetzte DM/zu eingesparter Primaerenergie) bestimmt. Dieses Instrument hat sich als Entscheidungshilfe bei der Auswahl der Massnahmen ausserordentlich bewaehrt. (orig.)

  19. Childrens&apos; Conceptions of Nature

    Science.gov (United States)

    Payne, Phillip

    2014-01-01

    This paper describes a study of sixth grade children&apos;s conceptions of nature and the environment. In so doing, it asks that environmental educators pay more attention to children&apos;s preconceived notions of environment and nature. Should this occur the theory-practice gap in environmental education may be diminished. Learners&apos; concept…

  20. Mineral and Elemental Composition Features of &apos;'Loose'&apos; Oolitic Ores in Bakchar Iron Ore Cluster (Tomsk Oblast)

    International Nuclear Information System (INIS)

    Geo-technological investigation considerations of iron ore deposits within the Bakchar ore cluster are being carried out. The mineral and elemental composition of &apos;'loose'&apos; ores have been studied, embracing such important aspects as the distribution pattern of valuable and harmful impurities, the determination of element concentrators (such as vanadium, phosphate and sulphur) in basic minerals and the analysis of ore composition varaiation in volume ore cluster. Based on investigation results the mineral and elemental composition characteristic features of &apos;'loose'&apos; ores were defined. Although hydrogoethite was the basic identified ore mineral, such minerals as goethite, lepidocrocite, leptochlorite, siderite and hisingerite were also found. The deportment of calcium phosphate (anapaite) and phosphates of rare-earth elements (monazite, killarite), which are associated with the harmful impurity- phosphorous, are described. It has been defined that the ore constituent composition contains such persistent impurities as vanadium and manganese, the content of which is 0.35% and 0.03%, respectively. The &apos;'loose'&apos; ores are continuous in mineral composition, both in area and cross-section throughout the Bakchar ore cluster. Based on the sample element composition analysis the most perspective areas for further mineral processing could be: western with the fraction of 1....0.2mm. and eastern- fraction of 1...0.1mm