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Sample records for apoe ko male

  1. Adenovirus-mediated sphingomyelin synthase 2 increases atherosclerotic lesions in ApoE KO mice

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    Zhao Yarui

    2011-01-01

    Full Text Available Abstract Background Sphingomyelin synthase 2 (SMS2 contributes to de novo sphingomyelin (SM biosynthesis. Its activity is related to SM levels in the plasma and the cell membrane. In this study, we investigated the possibility of a direct relationship between SMS and atherosclerosis. Methods The Adenovirus containing SMS2 gene was given into 10-week ApoE KO C57BL/6J mice by femoral intravenous injection. In the control group, the Adenovirus containing GFP was given. To confirm this model, we took both mRNA level examination (RT-PCR and protein level examination (SMS activity assay. Result We generated recombinant adenovirus vectors containing either human SMS2 cDNA (AdV-SMS2 or GFP cDNA (AdV-GFP. On day six after intravenous infusion of 2 × 1011 particle numbers into ten-week-old apoE KO mice, AdV-SMS2 treatment significantly increased liver SMS2 mRNA levels and SMS activity (by 2.7-fold, 2.3-fold, p Conclusions Our results present direct morphological evidence for the pro-atherogenic capabilities of SMS2. SMS2 could be a potential target for treating atherosclerosis.

  2. Hepatic glucose intolerance precedes hepatic steatosis in the male aromatase knockout (ArKO mouse.

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    Michelle L Van Sinderen

    Full Text Available Estrogens are known to play a role in modulating metabolic processes within the body. The Aromatase knockout (ArKO mice have been shown to harbor factors of Metabolic syndrome with central adiposity, hyperinsulinemia and male-specific hepatic steatosis. To determine the effects of estrogen ablation and subsequent replacement in males on whole body glucose metabolism, three- and six-month-old male ArKO mice were subjected to whole body glucose, insulin and pyruvate tolerance tests and analyzed for ensuing metabolic changes in liver, adipose tissue, and skeletal muscle. Estrogen-deficient male ArKO mice showed increased gonadal adiposity which was significantly reduced upon 17β-estradiol (E2 treatment. Concurrently, elevated ArKO serum leptin levels were significantly reduced upon E2 treatment and lowered serum adiponectin levels were restored to wild type levels. Three-month-old male ArKO mice were hyperglycemic, and both glucose and pyruvate intolerant. These phenotypes continued through to 6 months of age, highlighting a loss of glycemic control. ArKO livers displayed changes in gluconeogenic enzyme expression, and in insulin signaling pathways upon E2 treatment. Liver triglycerides were increased in the ArKO males only after 6 months of age, which could be reversed by E2 treatment. No differences were observed in insulin-stimulated ex vivo muscle glucose uptake nor changes in ArKO adipose tissue and muscle insulin signaling pathways. Therefore, we conclude that male ArKO mice develop hepatic glucose intolerance by the age of 3 months which precedes the sex-specific development of hepatic steatosis. This can be reversed upon the administration of exogenous E2.

  3. Echium Oil Reduces Atherosclerosis in apoB100-only LDLrKO Mice

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    Forrest, Lolita M.; Boudyguina, Elena; Wilson, Martha D.; Parks, John S.

    2012-01-01

    Introduction The anti-atherogenic and hypotriglyceridemic properties of fish oil are attributed to its enrichment in eicosapentaenoic acid (EPA; 20:5, n-3) and docosahexaenoic acid (DHA; 22:6, n-3). Echium oil contains stearidonic acid (SDA; 18:4, n-3), which is metabolized to EPA in humans and mice, resulting in decreased plasma triglycerides. Objective We used apoB100 only, LDLrKO mice to investigate whether echium oil reduces atherosclerosis. Methods Mice were fed palm, echium, or fish oil-containing diets for 16 weeks and plasma lipids, lipoproteins, and atherosclerosis were measured. Results Compared to palm oil, echium oil feeding resulted in significantly less plasma triglyceride and cholesterol levels, and atherosclerosis, comparable to that of fish oil. Conclusion This is the first report that echium oil is anti-atherogenic, suggesting that it may be a botanical alternative to fish oil for atheroprotection. PMID:22100249

  4. Resting-state functional connectivity changes in aging apoE4 and apoE-KO mice

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    Zerbi, V.; Wiesmann, M.; Emmerzaal, T.L.; Jansen, D.; Beek, M. van; Mutsaers, M.P.C.; Beckmann, C.F.; Heerschap, A.; Kiliaan, A.J.

    2014-01-01

    It is well established that the cholesterol-transporter apolipoprotein epsilon (APOE) genotype is associated with the risk of developing neuro-degenerative diseases. Recently, brain functional connectivity (FC) in apoE-epsilon 4 carriers has been investigated by means of resting-state fMRI, showing

  5. Resting-state functional connectivity changes in aging apoE4 and apoE-KO mice

    NARCIS (Netherlands)

    Zerbi, V.; Wiesmann, M.; Emmerzaal, T.L.; Jansen, D.; Beek, M. van; Mutsaers, M.P.; Beckmann, C.F.; Heerschap, A.; Kiliaan, A.J.

    2014-01-01

    It is well established that the cholesterol-transporter apolipoprotein epsilon (APOE) genotype is associated with the risk of developing neurodegenerative diseases. Recently, brain functional connectivity (FC) in apoE-epsilon4 carriers has been investigated by means of resting-state fMRI, showing a

  6. Sex Differences in Presynaptic Density and Neurogenesis in Middle-Aged ApoE4 and ApoE Knockout Mice

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    A. Rijpma

    2013-01-01

    Full Text Available Atherosclerosis and apolipoprotein E ε4 (APOE4 genotype are risk factors for Alzheimer’s disease (AD and cardiovascular disease (CVD. Sex differences exist in prevalence and manifestation of both diseases. We investigated sex differences respective to aging, focusing on cognitive parameters in apoE4 and apoE knockout (ko mouse models of AD and CVD. Presynaptic density and neurogenesis were investigated immunohistochemically in male and female apoE4, apoE ko, and wild-type mice. Middle-aged female apoE4 mice showed decreased presynaptic density in the inner molecular layer of the dentate gyrus of the hippocampus. Middle-aged female apoE ko mice showed a trend towards increased neurogenesis in the hippocampus compared with wild-type mice. No differences in these parameters could be observed in middle-aged male mice. Specific harmful interactions between apoE4 and estrogen could be responsible for decreased presynaptic density in female apoE4 mice. The trend of increased neurogenesis found in female apoE ko mice supports previous studies suggesting that temporarily increased amount of synaptic contacts and/or neurogenesis is a compensatory mechanism for synaptic failure. To our knowledge, no other studies investigating presynaptic density in aging female apoE4 or apoE ko mice are available. Sex-specific differences between APOE genotypes could account for some sex differences in AD and CVD.

  7. Karyotype analysis of a male exhibiting Meckel's diverticulum and aural atresia

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    Frizzell, B.; Hicks, M.F. (David Lipscomb Univ., Nashville, TN (United States))

    Patau's Syndrome is caused by inheritance of an extra chromosome 13. It is characterized primarily by severe mental retardation, cleft palate, and retarded growth. Most fetuses expressing Patau's Syndrome spontaneously abort, and those that are born usually die before one year. Both Meckel's diverticulum and aural atresia are defects found in patients with Patau's at levels higher than those in the general population. An otherwise asymptomatic male expressing only Meckel's diverticulum and aural atresia has a female sibling whose son expressed Patau's syndrome. Twenty percent of patients with Patau's show a translocation of part of chromosome 13 to another D chromosome. If a translocation were the cause of the expression of Patau's in this family, it is possible that the normal male inherited a balanced translocation and the Patau's male received an unbalanced translocation. A karyotype analysis of the non-Patau's male was done to determine if such a translocation were present.

  8. Clusterin signals via ApoER2/VLDLR and induces meiosis of male germ cells

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    Riaz, Muhammad Assad; Stammler, Angelika; Borgers, Mareike; Konrad, Lutz

    2017-01-01

    Clusterin (CLU) is a ubiquitously expressed heterodimeric glycoprotein that is involved in a variety of functions like cell-cell interactions, apoptosis, epithelial-mesenchymal transition, carcinogenesis, and chaperone function. In the testis, CLU is strongly expressed especially in Sertoli cells but very little is known about its testicular function, regulation of secretion and most enigmatic, its receptor(s). In this study, we approached these questions with a special emphasis on the link between CLU and meiosis. In cultured seminiferous tubules, we found that secretion of CLU protein is upregulated by transforming growth factor-betas (TGF-β1-3) and observed inhibition of staurosporine-induced apoptosis by recombinant CLU. Clusterin signaling in testicular cells seems to be modulated by very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2), because these members of the low density lipoprotein (LDL) receptor family are present in rat germ cells. Furthermore, inhibition of VLDLR/ApoER2 by a specific inhibitor abrogates CLU-mediated phosphorylation of Akt, which mediates VLDLR/ApoER2 signaling. We could also show in tubules treated with recombinant CLU a significant upregulation of several meiosis-associated proteins such as V-myb avian myeloblastosis viral oncogene homolog-like 1 (Mybl1), stimulated by retinoic acid gene 8 (Stra8), lactate dehydrogenase C (LDHC), cAMP response element-binding protein (CREB) and histone H3 (H3S10P). Collectively, our data show for the first time the involvement of CLU in upregulation of meiosis through VLDLR/ApoER2 in male germ cells. PMID:28386352

  9. "But I'm Oppressed Too": White Male College Students Framing Racial Emotions as Facts and Recreating Racism

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    Cabrera, Nolan L.

    2014-01-01

    Most analyses of racism focus on what people think about issues of race and how this relates to racial stratification. This research applies Feagin's "white racial frame" to analyze how White male college students at two universities "feel" about racism. Students at the academically non-selective and less diverse…

  10. "I 'See' Trayvon Martin": What Teachers Can Learn from the Tragic Death of a Young Black Male

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    Love, Bettina L.

    2014-01-01

    The goal of this article is to examine the racially hostile environment of U.S. public schooling towards Black males. Drawing on the work of Foucault ("Discipline and punish. The birth of the prison," Penguin Books, London, 1977; "Michel Foucault: beyond structuralism and hermeneutics," The Harvester Press, Brighton, 1982)…

  11. Differentiation in boron distribution in adult male and female rats' normal brain: A BNCT approach

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    Goodarzi, Samereh, E-mail: samere.g@gmail.com [Department of Nuclear Engineering, Science and Research Branch, Islamic Azad University, PO Box 19395-1943, Tehran (Iran, Islamic Republic of); Pazirandeh, Ali, E-mail: paziran@yahoo.com [Department of Nuclear Engineering, Science and Research Branch, Islamic Azad University, PO Box 19395-1943, Tehran (Iran, Islamic Republic of); Jameie, Seyed Behnamedin, E-mail: behnamjameie@tums.ac.ir [Basic Science Department, Faculty of Allied Medicine, Tehran University of Medical Sciences, Tehran (Iran, Islamic Republic of); Department of Anatomy, Faculty of Medicine, Tehran University of Medical Sciences, Tehran (Iran, Islamic Republic of); Baghban Khojasteh, Nasrin, E-mail: khojasteh_n@yahoo.com [Department of Nuclear Engineering, Science and Research Branch, Islamic Azad University, PO Box 19395-1943, Tehran (Iran, Islamic Republic of)

    2012-06-15

    Boron distribution in adult male and female rats' normal brain after boron carrier injection (0.005 g Boric Acid+0.005 g Borax+10 ml distilled water, pH: 7.4) was studied in this research. Coronal sections of control and trial animal tissue samples were irradiated with thermal neutrons. Using alpha autoradiography, significant differences in boron concentration were seen in forebrain, midbrain and hindbrain sections of male and female animal groups with the highest value, four hours after boron compound injection. - Highlights: Black-Right-Pointing-Pointer Boron distribution in male and female rats' normal brain was studied in this research. Black-Right-Pointing-Pointer Coronal sections of animal tissue samples were irradiated with thermal neutrons. Black-Right-Pointing-Pointer Alpha and Lithium tracks were counted using alpha autoradiography. Black-Right-Pointing-Pointer Different boron concentration was seen in brain sections of male and female rats. Black-Right-Pointing-Pointer The highest boron concentration was seen in 4 h after boron compound injection.

  12. Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1 and ApoE.

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    Bart Lammers

    Full Text Available AIM: ABCA1 protects against atherosclerosis by facilitating cholesterol efflux from macrophage foam cells in the arterial wall to extracellular apolipoprotein (apo A-I. In contrast to apoA-I, apoE is secreted by macrophages and can, like apoA-I, induce ABCA1-mediated cholesterol efflux. Yet, the combined effect of macrophage ABCA1 and apoE on lesion development is unexplored. METHODS AND RESULTS: LDL receptor knockout (KO mice were transplanted with bone marrow from ABCA1/apoE double KO (dKO mice, their respective single KO's, and wild-type (WT controls and were challenged with a high-fat/high-cholesterol diet for 9 weeks. In vitro cholesterol efflux experiments showed no differences between ABCA1 KO and dKO macrophages. The serum non-HDL/HDL ratio in dKO transplanted mice was 1.7-fold and 2.4-fold (p<0.01 increased compared to WT and ABCA1 KO transplanted mice, respectively. The atherosclerotic lesion area in dKO transplanted animals (650±94×10(3 µm(2, however, was 1.9-fold (p<0.01 and 1.6-fold (p<0.01 increased compared to single knockouts (ABCA1 KO: 341±20×10(3 µm(2; apoE KO: 402±78×10(3 µm(2, respectively and 3.1-fold increased (p<0.001 compared to WT (211±20×10(3 µm(2. When normalized for serum cholesterol exposure, macrophage ABCA1 and apoE independently protected against atherosclerotic lesion development (p<0.001. Moreover, hepatic expression levels of TNFα and IL-6 were highly induced in dKO transplanted animals (3.0-fold; p<0.05, and 4.3-fold; p<0.001, respectively. In agreement, serum IL-6 levels were also enhanced in ABCA1 KO transplanted mice (p<0.05 and even further enhanced in dKO transplanted animals (3.1-fold as compared to ABCA1 KO transplanted animals; p<0.05. CONCLUSIONS: Combined deletion of macrophage ABCA1 and apoE results in a defect in cholesterol efflux and, compared to ABCA1 KO transplanted mice, elevated serum total cholesterol levels. Importantly, these mice also suffer from enhanced systemic and hepatic

  13. Casanovas are liars: behavioral syndromes, sperm competition risk, and the evolution of deceptive male mating behavior in live-bearing fishes [v2; ref status: indexed, http://f1000r.es/1ko

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    David Bierbach

    2013-08-01

    Full Text Available Male reproductive biology can by characterized through competition over mates as well as mate choice. Multiple mating and male mate choice copying, especially in internally fertilizing species, set the stage for increased sperm competition, i.e., sperm of two or more males can compete for fertilization of the female’s ova. In the internally fertilizing fish Poecilia mexicana, males respond to the presence of rivals with reduced expression of mating preferences (audience effect, thereby lowering the risk of by-standing rivals copying their mate choice. Also, males interact initially more with a non-preferred female when observed by a rival, which has been interpreted in previous studies as a strategy to mislead rivals, again reducing sperm competition risk (SCR. Nevertheless, species might differ consistently in their expression of aggressive and reproductive behaviors, possibly due to varying levels of SCR. In the current study, we present a unique data set comprising ten poeciliid species (in two cases including multiple populations and ask whether species can be characterized through consistent differences in the expression of aggression, sexual activity and changes in mate choice under increased SCR. We found consistent species-specific differences in aggressive behavior, sexual activity as well as in the level of misleading behavior, while decreased preference expression under increased SCR was a general feature of all but one species examined. Furthermore, mean sexual activity correlated positively with the occurrence of potentially misleading behavior. An alternative explanation for audience effects would be that males attempt to avoid aggressive encounters, which would predict stronger audience effects in more aggressive species. We demonstrate a positive correlation between mean aggressiveness and sexual activity (suggesting a hormonal link as a mechanistic explanation, but did not detect a correlation between aggressiveness and

  14. The Problem of Privilege: Male Social Work Students&apos; Preservice Experiences

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    Giesler, Mark A.

    2013-01-01

    Male social work students are a numerical minority in Bachelor of Social Work (BSW) programs, a reality that warrants exploration as the academy strives for greater diversity within preservice social work programs. The present qualitative phenomenological study examined how male social work students in one BSW university program perceived their…

  15. Emotions or Science? Pre-Tertiary Males&apos; Accounts of Psychology as a Subject Choice

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    Mercer, Jenny; Sander, Paul; Williams, Stella; Jones, Tim

    2013-01-01

    It is well established that the number of males studying psychology in the UK, both at A-level and on degree courses, is disproportionately low compared to females. There is a paucity of research, however, which discusses how psychology is viewed by this group. The present study employed focus groups with 35 pre-tertiary males (some of whom were…

  16. Targeted overexpression of the human urotensin receptor transgene in smooth muscle cells: effect of UT antagonism in ApoE knockout mice fed with Western diet.

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    Papadopoulos, Panayiota; Bousette, Nicolas; Al-Ramli, Wisam; You, Zhipeng; Behm, David J; Ohlstein, Eliot H; Harrison, Stephen M; Douglas, Stephen A; Giaid, Adel

    2009-06-01

    Urotensin II (UII) and its receptor UT are upregulated in the pathological setting of various cardiovascular diseases including atherosclerosis. However, their exact role in atherosclerosis remains to be determined. In the present study we used four strains of mice; wild-type (WT), UT(+) (a transgenic strain expressing human UT driven by the alpha-smooth muscle-specific, SM22, promoter), ApoE knockout (ko), and UT(+)/ApoE ko. All animals were fed high fat diet for 12 weeks. Western blot analysis revealed a significant increase in aortic UT expression in UT(+) relative to WT mice (PUT protein level to that of UT(+). Immunohistochemistry revealed the presence of strong expression of UT and UII proteins in the atheroma of UT(+), ApoE ko and UT(+)/ApoE ko mice, particularly in foam cells. Serum cholesterol and triglyceride levels were significantly increased in ApoE ko and in UT(+)/ApoE ko but not in UT(+) mice when compared to WT mice (PUT(+), ApoE ko and UT(+)/ApoE ko compared to WT mice (PUT receptor antagonist SB-657510A (30 microg/Kg/day gavage) for 10 weeks in a group of ApoE ko mice fed on high fat diet resulted in a significant reduction of lesion (PUT in the pathogenesis of atherosclerosis. The use of UT receptor antagonists may provide a beneficial tool in the management of this debilitating disease process.

  17. Genetic manipulation of the ApoF/Stat2 locus supports an important role for type I interferon signaling in atherosclerosis.

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    Lagor, William R; Fields, David W; Bauer, Robert C; Crawford, Alison; Abt, Michael C; Artis, David; Wherry, E John; Rader, Daniel J

    2014-03-01

    Apolipoprotein F (ApoF) is a sialoglycoprotein that is a component of the HDL and LDL fractions of human serum. We sought to test the hypothesis that ApoF plays an important role in atherosclerosis in mice by modulating lipoprotein function. Atherosclerosis was assessed in male low density lipoprotein receptor knockout (Ldlr KO) and ApoF/Ldlr double knockout (DKO) mice fed a Western diet for 16 weeks. ApoF/Ldlr DKO mice showed a 39% reduction in lesional area by en face analysis of aortas (p atherosclerosis, and support the growing evidence that the Type I IFN pathway may contribute to this complex disease.

  18. Camian microfossils from Bevško

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    Tea Kolar-Jurkovšek

    1994-12-01

    Full Text Available In the section west of Bevško with prevailing platy limestone the fossil microfauna was studied. The association consists of foraminifers, ostracods,conodonts and fish remains. Determined microfauna is characterized by the conodont element Neogondolella polygnathiformis indicating the Carnian stage.

  19. Intraperitoneal CCK and fourth-intraventricular Apo AIV require both peripheral and NTS CCK1R to reduce food intake in male rats.

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    Lo, Chunmin C; Davidson, W Sean; Hibbard, Stephanie K; Georgievsky, Maria; Lee, Alexander; Tso, Patrick; Woods, Stephen C

    2014-05-01

    Apolipoprotein AIV (Apo AIV) and cholecystokinin (CCK) are secreted in response to fat consumption, and both cause satiation via CCK 1 receptor (CCK-1R)-containing vagal afferent nerves to the nucleus of the solitary tract (NTS), where Apo AIV is also synthesized. Fasted male Long-Evans rats received ip CCK-8 or fourth-ventricular (i4vt) Apo AIV alone or in combination. Food intake and c-Fos proteins (a product of the c-Fos immediate-early gene) were assessed. i4vt Apo AIV and/or ip CCK at effective doses reduced food intake and activated c-Fos proteins in the NTS and hypothalamic arcuate nucleus and paraventricular nucleus. Blockade of the CCK-1R by i4vt lorglumide adjacent to the NTS attenuated the satiating and c-Fos-stimulating effects of CCK and Apo AIV, alone or in combination. Maintenance on a high-fat diet (HFD) for 10 weeks resulted in weight gain and attenuation of both the behavioral and c-Fos responses to a greater extent than occurred in low-fat diet-fed and pair-fed HFD animals. These observations suggest that NTS Apo AIV or/and peripheral CCK requires vagal CCK-1R signaling to elicit satiation and that maintenance on a HFD reduces the satiating capacity of these 2 signals.

  20. The effects of prenatal sound stress on the spatial learning and memory of rat&apos;s male offspring

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    Barzegar M

    2011-01-01

    Full Text Available "n 800x600 Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} Background: Numerous evidences indicate that various environmental stresses during pregnancy affect physiological behavior of the offspring. This experimental study was designed to investigate the effect of noise stress during prenatal period of rats on spatial learning and memory and plasma corticostrone level in postnatal life."n"nMethods: Three groups of pregnant rats were given daily noise stress with durations of two and/ or four hours in last week of pregnancy period. The fourth group was left unstressed. The male offspring from the unstressed and different stressed groups were assigned as controls and stressed groups. The animals were introduced to a spatial task in Morris water maze 4 trials/day for five consecutive days. The probe test was performed on the 5th day of the experiment. The delay in findings and the distance passed to locate the target platform were assessed as the spatial learning. "n"nResults: Our results showed that prenatal exposure to noise stress for two and/ or four hours a day, leads to impaired acquisition of spatial learning in the postnatal animals. The plasma level of corticostrone in the two stressed groups of rats markedly matched with their behavioral function. Prenatal exposure to 1- hour noise stress revealed no effects on the offsprings&apos; behavior and plasma corticostrone level."n"nConclusion: Based on our study results, it seems that applied range of stress which is executed through the noise stress could increase the plasma corticostrone level and

  1. Ethanol production by Escherichia coli KO11; Producao de etanol por Escherichia coli KO11

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    Lima, Katia Gianni de Carvalho [Sao Paulo Univ., SP (Brazil). Faculdade de Ciencias Farmaceuticas. Lab. de Microbiologia de Alimentos]. E-mail: gianni@usp.br; Takahashi, Caroline Maki; Alterthum, Flavio [Sao Paulo Univ., SP (Brazil). Inst. de Ciencias Biomedicas. Dept. de Microbiologia

    2002-08-01

    This paper discusses the potential use of Escherichia coli KO11 in production of ethanol, based on observation that this organism can efficiently metabolize sugar complex moistures obtained from the acid hydrolysis of lignocellulose materials such as sugar-cane bagasse, corncob, corn husk, Pinus sp and oak wood.

  2. But We&apos;re Not Laughing: White Male College Students&apos; Racial Joking and What This Says about "Post-Racial" Discourse

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    Cabrera, Nolan L.

    2014-01-01

    This study critically analyzes White male college student narratives regarding racial joking. Through semi-structured interviews, 29 participants described a pattern of behavior and rationalization: they heard and told racist jokes frequently; the jokes were framed as not racist; and the jokes were told only among White people, because the…

  3. "I&apos;m Khmer and I&apos;m Not a Gangster!": The Problematization of Cambodian Male Youth in US Schools

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    Chhuon, Vichet

    2014-01-01

    In response to a literature that has paid limited attention to the complex representations of Cambodian students, this article investigated the ways in which Cambodian male youth were problematized in school through Discourses that presented them as apathetic students and/or gang members at one California high school. In this study, the ways in…

  4. Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO mice.

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    Jingbo Pang

    Full Text Available Obesity and type 2 diabetes are associated with increased production of Galectin-3 (Gal-3, a protein that modulates inflammation and clearance of glucose adducts. We used Lean and Diet-induced Obese (DIO WT and Gal-3 KO mice to investigate the role of Gal-3 in modulation of adiposity, glucose metabolism and inflammation. Deficiency of Gal-3 lead to age-dependent development of excess adiposity and systemic inflammation, as indicated by elevated production of acute-phase proteins, number of circulating pro-inflammatory Ly6C(high monocytes and development of neutrophilia, microcytic anemia and thrombocytosis in 20-week-old Lean and DIO male Gal-3 KO mice. This was associated with impaired fasting glucose, heightened response to a glucose tolerance test and reduced adipose tissue expression of adiponectin, Gal-12, ATGL and PPARγ, in the presence of maintained insulin sensitivity and hepatic expression of gluconeogenic enzymes in 20-week-old Gal-3 KO mice compared to their diet-matched WT controls. Expression of PGC-1α and FGF-21 in the liver of Lean Gal-3 KO mice was comparable to that observed in DIO animals. Impaired fasting glucose and altered responsiveness to a glucose load preceded development of excess adiposity and systemic inflammation, as demonstrated in 12-week-old Gal-3 KO mice. Finally, a role for the microflora in mediating the fasting hyperglycemia, but not the excessive response to a glucose load, of 12-week-old Gal-3 KO mice was demonstrated by administration of antibiotics. In conclusion, Gal-3 is an important modulator of glucose metabolism, adiposity and inflammation.

  5. Contact karst of Kočevski Rog and Kočevska Mala gora

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    Petra Gostinčar

    2011-12-01

    Full Text Available On high Dinaric karst plateaus of Kočevski Rog and Kočevska Mala gora, the so-called contact karst is present. Geomorphic processes and landforms of four case study areas of contact karst were researched in detail. Two types of contact karst were recognized: between non-carbonate and carbonate rocks and between different carbonate rocks. In the first case, ponors and blind valleys (active and fossil were formed and concave forms near the contact are infilled with non-carbonate sediments. On the contact between different carbonate rocks (dolomite and limestone, the forms are similar but less evident, e.g. ponors (active and fossil, ponor steepheads and dry valleys.

  6. KoKoRu: konfessionell-kooperativer Religionsunterricht – ‚das Wiener Modell’

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    Sonja Danner

    2015-11-01

    Full Text Available ENGLISH: Due to the rising number of confessions / religions acknowledged by the state religious education in schools is coming up in a greater variety. Rising expenses and rising problems in making timetables are two of the first consequences. Therefore years ago a group of teachers, school inspectors of RE etc. has been formed with the intention to think about alternative forms of RE in Austria. These ideas of RE have been proved in several schools in Vienna. Teachers were trained in specific courses to put into practice the concept and together with them the RE lessons were evaluated and didactics of the model of KoKoRU (confessional cooperation in RE were developed. In the meanwhile this concept of teaching RE is an inherent part of RE-teachers‘ education at the KPH Wien/Krems, even though the model only gained ground in some schools of Vienna. DEUTSCH: Mit dem Ansteigen der anerkannten Konfessionen/Religionen erfährt auch der Religionsunterricht an Schulen eine größere Vielfalt. Damit verbunden sind erhöhte Kosten und viele ‚stundenplantechnische‘ Stolpersteine. Die Unterbringung der Religionsstunden in den Regelunterricht wird immer schwieriger. Daher hat sich vor Jahren eine Gruppe von Lehrenden, Fachinspektor/innen etc. zusammengefunden, um über alternative Formen des Religionsunterrichtes in Österreich nachzudenken und diese an ausgewählten Schulen in Wien erprobt. Dafür wurden in eigenen Lehrgängen LehrerInnen ausgeblidet und mit ihnen gemeinsam evaluiert und ein didaktisches Konzept für KoKoRu - konfessionell kooperativen Religionsunterricht- entwickelt. Mittlerweile ist diese Form des Unterrichtens auch in die Ausbildung an der KPH Wien/Krems für künftige ReligionslehrerInnen eingegangen, auch wenn das Modell nur zum Teil in Wien Fuß gefasst hat.

  7. Exercise training and antioxidant supplementation independently improve cognitive function in adult male and female GFAP-APOE mice

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    Kiran Chaudhari

    2014-09-01

    Conclusion: Exercise was the most effective treatment at improving cognitive function in both genotypes and sex, while antioxidants seemed to be effective only in the APOE4. In young adult mice only non-spatial learning and memory were improved. The combination of the two treatments did not yield further improvement in cognition, and there was no antagonistic action of the antioxidant supplementation on the beneficial effects of exercise.

  8. NEXAFS multiple scattering calculations of KO2

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    M.Pedio; Z.Y.Wu; M.Benfatto; A.Mascaraque; E.Michel; C.Crotti; M.Pel

    2001-01-01

    Since many years the oxidation of alkali metals has being attracted much interest due to the catalytic properties of metal promoters and the simple electronic structure of alkali atoms.The alkali-oxides phase diagram indicates that the interaction of oxygen with alkali metals can lead to the formation of different atomic O2 ions and molecular O2 and O22- ions.Potassium superoxide has been prepared in situ and high resolution O e-edge absorption NEXAFS spectra have been measured at the VUV beam-Line at ELETTRA facility.The experimental data have been analyzed by multiple scattering approach deriving many geometrical and electronic is of the KO2 type with an O-O distance of about 1.35A and that the transition involving singleπ molecular empty state of the superoxied O2 anion has a fine structure.Multiple Scattering self consistent calculation indicates that the bond between oxygen anion adn K atom is totally ionic and that the fine structure is essentially due to solid state effects.

  9. Brother, Will You Lend a Hand? Perceptions of Undergraduate African American Male Proteges&apos; Formal Mentoring Journey

    Science.gov (United States)

    Mason, John Leonard, Jr.

    2012-01-01

    African American males fail to graduate from colleges and universities as compared to any other demographic. The impact of this non-completion failure continues to touch the African American family structure, community stability, economic reduction at all levels, and an increasing situational hopelessness. The literature surrounding the struggles…

  10. Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice

    Directory of Open Access Journals (Sweden)

    Qin Xu

    2012-12-01

    Full Text Available Nitric oxide (NO, synthesized as needed by NO synthase (NOS, is involved in spinogenesis and synaptogenesis. Immature spine morphology is characteristic of fragile X syndrome (FXS. The objective of this research was to investigate and compare changes of postnatal neuronal NOS (nNOS expression in the hippocampus of male fragile X mental retardation 1 gene knockout mice (FMR1 KO mice, the animal model of FXS and male wild-type mice (WT at postnatal day 7 (P7, P14, P21, and P28. nNOS mRNA levels were analyzed by real-time quantitative PCR (N = 4-7 and nNOS protein was estimated by Western blot (N = 3 and immunohistochemistry (N = 1. In the PCR assessment, primers 5’-GTGGCCATCGTGTCCTACCATAC-3’ and 5’-GTTTCGAGGCAGGTGGAAGCTA-3’ were used for the detection of nNOS and primers 5’-CCGTTTCTCCTGGCTCAGTTTA-3’ and 5’-CCCCAATACCACATCATCCAT-3’ were used for the detection of β-actin. Compared to the WT group, nNOS mRNA expression was significantly decreased in FMR1 KO mice at P21 (KO: 0.2857 ± 0.0150, WT: 0.5646 ± 0.0657; P < 0.05. Consistently, nNOS immunoreactivity also revealed reduced staining intensity at P21 in the FMR1 KO group. Western blot analysis validated the immunostaining results by demonstrating a significant reduction in nNOS protein levels in the FMR1 KO group compared to the WT group at P21 (KO: 0.3015 ± 0.0897, WT: 1.7542 ± 0.5455; P < 0.05. These results suggest that nNOS was involved in the postnatal development of the hippocampus in FXS and impaired NO production may retard spine maturation in FXS.

  11. Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Qin; Zhu, Zhiwei; Xu, Jialu [Department of Children' s Health Care, Children' s Hospital, Zhejiang University, Hangzhou Zhejiang (China); Gu, Weizhong [Department of Pathology, Children' s Hospital, Zhejiang University, Hangzhou Zhejiang (China); Zhao, Zhengyan [Department of Children' s Health Care, Children' s Hospital, Zhejiang University, Hangzhou Zhejiang (China)

    2012-10-05

    Nitric oxide (NO), synthesized as needed by NO synthase (NOS), is involved in spinogenesis and synaptogenesis. Immature spine morphology is characteristic of fragile X syndrome (FXS). The objective of this research was to investigate and compare changes of postnatal neuronal NOS (nNOS) expression in the hippocampus of male fragile X mental retardation 1 gene knockout mice (FMR1 KO mice, the animal model of FXS) and male wild-type mice (WT) at postnatal day 7 (P7), P14, P21, and P28. nNOS mRNA levels were analyzed by real-time quantitative PCR (N = 4-7) and nNOS protein was estimated by Western blot (N = 3) and immunohistochemistry (N = 1). In the PCR assessment, primers 5′-GTGGCCATCGTGTCCTACCATAC-3′ and 5′-GTTTCGAGGCAGGTGGAAGCTA-3′ were used for the detection of nNOS and primers 5′-CCGTTTCTCCTGGCTCAGTTTA-3′ and 5′-CCCCAATACCACATCATCCAT-3′ were used for the detection of β-actin. Compared to the WT group, nNOS mRNA expression was significantly decreased in FMR1 KO mice at P21 (KO: 0.2857 ± 0.0150, WT: 0.5646 ± 0.0657; P < 0.05). Consistently, nNOS immunoreactivity also revealed reduced staining intensity at P21 in the FMR1 KO group. Western blot analysis validated the immunostaining results by demonstrating a significant reduction in nNOS protein levels in the FMR1 KO group compared to the WT group at P21 (KO: 0.3015 ± 0.0897, WT: 1.7542 ± 0.5455; P < 0.05). These results suggest that nNOS was involved in the postnatal development of the hippocampus in FXS and impaired NO production may retard spine maturation in FXS.

  12. Construction of the world&apos;s first continuous PC steel composite extradosed bridge. New Meishin Expressway Kiso River Bridge and Ibi River Bridge; Sekaihatsu no PC {center_dot} ko fukugo renzoku ekusutora dozudo kyo no seko. Dai 2 meishin kosoku doro Kisogawa kyo {center_dot} Ibigawa kyo

    Energy Technology Data Exchange (ETDEWEB)

    Mizuguchi, Kazuyuki; Nakasu, Makoto [Japan Highway Public Corpration, Tokyo (Japan)

    1999-09-10

    Kiso River Bridge and Ibi River bridge in the Second Meishin Expressway are the bridges lying across the river mouths of Kiso River and Ibi River which are two of the biggest rivers in Japan. Since a span length of 160m or more is necessary when constructing the bridges, comparison examinations in respect to bridge forms that can secure a long span were carried out. As a result, the world&apos;s first continuous PC steel composite extradosed bridge was adopted. The construction works of these two bridges were each divided into the east and the west works, thus totally four constructions works were ordered. Now both the two bridges are approaching the most active period of their superstructure works. In this paper, summary of the superstructure works of these two bridges is described and the situation of concrete girder portions operated hitherto is introduced. Particularly, for the concrete girder portions in composite structures, an extrodosed form is employed to arrange PC members outside the girders so as to use them more effectively and make prestress force act on a main girder at a great eccentricity. (NEDO)

  13. Avdjuško kinkis oma mehele seksfilmi / Maris Sander

    Index Scriptorium Estoniae

    Sander, Maris

    2009-01-01

    Maria Avdjuško kinkis abikaasa Kris Taskale sünnipäevaks režissööridebüüdina valminud lühifilmi "Mis su nimi on?". Filmi peaosaline on iseennast mängiv Tallinna Ülikooli lektor Linnar Priimägi, kaasosaline näitleja Taavi Eelmaa

  14. Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr.

    Science.gov (United States)

    Lloyd, David J; McCormick, Jocelyn; Helmering, Joan; Kim, Ki Won; Wang, Minghan; Fordstrom, Preston; Kaufman, Stephen A; Lindberg, Richard A; Véniant, Murielle M

    2008-03-01

    The metabolic syndrome is a group of disorders including obesity, insulin resistance, atherogenic dyslipidemia, hyperglycemia, and hypertension. To date, few animal models have been described to recapitulate the phenotypes of the syndrome. In this study, we generated and characterized two lines of triple-knockout mice that are deficient in either apolipoprotein E (Apoe(-/-)) or low-density lipoprotein receptor (Ldlr(-/-)) and express no leptin (Lep(ob/ob)) or apolipoprotein B-48 but exclusively apolipoprotein B-100 (Apob(100/100)). These two lines are referred to as Apoe triple-knockout-Apoe 3KO (Apoe(-/-)Apob(100/100)Lep(ob/ob)) and Ldlr triple-knockout-Ldlr 3KO (Ldlr(-/-)Apob(100/100)Lep(ob/ob)) mice. Both lines develop obesity, hyperinsulinemia, hyperlipidemia, hypertension, and atherosclerosis. However, only Apoe 3KO mice are hyperglycemic and glucose intolerant and are more obese than Ldlr 3KO mice. To evaluate the utility of these lines as pharmacological models, we treated both with leptin and found that leptin therapy ameliorated most metabolic derangements. Leptin was more effective in improving glucose tolerance in Ldlr 3KO than Apoe 3KO animals. The reduction of plasma cholesterol by leptin in Ldlr 3KO mice can be accounted for by its suppressive effect on food intake. However, in Apoe 3KO mice, leptin further reduced plasma cholesterol independently of its effect on food intake, and this improvement correlated with a smaller plaque lesion area. These effects suggest a direct role of leptin in modulating VLDL levels and, likewise, the lesion areas in VLDL-enriched animals. These two lines of mice represent new models with features of the metabolic syndrome and will be useful in testing therapies targeted for combating the human condition.

  15. Hepatic caveolin-1 is enhanced in Cyp27a1/ApoE double knockout mice.

    Science.gov (United States)

    Zurkinden, Line; Mansour, Yosef T; Rohrbach, Beatrice; Vogt, Bruno; Mistry, Hiten D; Escher, Geneviève

    2016-10-01

    Sterol 27-hydroxylase (CYP27A1) is involved in bile acid synthesis and cholesterol homoeostasis. Cyp27a1((-/-))/Apolipoprotein E((-/-)) double knockout mice (DKO) fed a western diet failed to develop atherosclerosis. Caveolin-1 (CAV-1), the main component of caveolae, is associated with lipid homoeostasis and has regulatory roles in vascular diseases. We hypothesized that liver CAV-1 would contribute to the athero-protective mechanism in DKO mice. Cyp27a1((+/+))/ApoE((-/-)) (ApoE KO), Cyp27a1((+/-))/ApoE((-/-)) (het), and DKO mice were fed a western diet for 2 months. Atherosclerotic plaque and CAV-1 protein were quantified in aortas. Hepatic Cav-1 mRNA was assessed using qPCR, CAV-1 protein by immunohistochemistry and western blotting. Total hepatic and plasma cholesterol was measured using chemiluminescence. Cholesterol efflux was performed in RAW264.7 cells, using mice plasma as acceptor. CAV-1 protein expression in aortas was increased in endothelial cells of DKO mice and negatively correlated with plaque surface (P < 0.05). In the liver, both CAV-1 protein and mRNA expression doubled in DKO, compared to ApoE KO and het mice (P < 0.001 for both) and was negatively correlated with total hepatic cholesterol (P < 0.05). Plasma from DKO, ApoE KO and het mice had the same efflux capacity. In the absence of CYP27A1, CAV-1 overexpression might have an additional athero-protective role by partly overcoming the defect in CYP27A1-mediated cholesterol efflux.

  16. The &apos;'neural'&apos; phonetic typewriter

    Energy Technology Data Exchange (ETDEWEB)

    Kohonen, T.

    1988-03-01

    Recently, researchers have placed great hopes on artificial neural networks to perform such &apos;'natural'&apos; tasks as speech recognition. This was indeed one motivation for us to start research in this area many years ago at Helsinki University of Technology. This article describes the result of that research - a complete &apos;'neural'&apos; speech recognition system, which recognizes phonetic units, called phonemes, from a continuous speech signal. Although motivated by neural network principles, the choices in design must be regarded as a compromise of many technical aspects of those principles. As our system is a genuine &apos;&apos;phonetic typewriter&apos;&apos; intended to transcribe orthographically edited text from an unlimited vocabulary, it cannot be directed compared with any more conventional, word-based system that applies classical concepts such as dynamic time warping and hidden Markov models.

  17. 3D RAČUNALNIŠKO KONSTRUIRANJE OBLAČIL

    OpenAIRE

    Košir, Nataša

    2013-01-01

    Dandanes, ko je napredek tehnologije na vrhuncu, se tudi v tekstilni industriji srečujemo z naprednimi tehnologijami, ki poenostavljajo izdelavo oblačil in manjšajo stroške oblačil. V diplomski nalogi smo raziskali prednosti in slabosti programske opreme Optitex 3D Flattening. Ta programska oprema nudi možnost konstruiranja krojev oblačil na 3D parametričnem modelu telesa. V uvodnem delo diplomske naloge so predstavljeni programi, ki se ukvarjajo s 3D konstruiranjem, podane so osnove 2D in...

  18. Ne-nekrotizirajuće bakterijske infekcije kože

    OpenAIRE

    2014-01-01

    Koža je barijera koja je kolonizirana apatogenim bakterijama koje ograničavaju invaziju i rast patogenih bakterija. Najčešće bakterijske infekcije kože jesu piodermije uzrokovane beta hemolitičkim streptokokom (BHS) ili zlatnim stafilokokom (SA). Impetigo je površinska infekcija kože najčešće djece predškolske dobi uzrokovana BHS ili SA. Terapijski pristup ovisi o broju i veličini kožnih promjena. Apsces kože zahtjeva inciziju, evakuaciju gnoja, a ponekad i antimikrobnu terapiju. Folikulitis,...

  19. Classical and alternative activation and metalloproteinase expression occurs in foam cell macrophages in male and female ApoE null mice in the absence of T- and B-lymphocytes

    Directory of Open Access Journals (Sweden)

    Elaine Mo Hayes

    2014-10-01

    Full Text Available Background: Rupture of advanced atherosclerotic plaques accounts for most life-threatening myocardial infarctions. Classical (M1 and alternative (M2 macrophage activation could promote atherosclerotic plaque progression and rupture by increasing production of proteases, including matrix metalloproteinases (MMPs. Lymphocyte-derived cytokines may be essential for generating M1 and M2 phenotypes in plaques, although this has not been rigorously tested until now.Methods and Results: We validated the expression of M1 markers (iNOS and COX-2 and M2 markers (arginase-1, Ym-1 and CD206 and then measured MMP mRNA levels in mouse macrophages during classical and alternative activation in vitro. We then compared mRNA expression of these genes ex vivo in foam cells from subcutaneous granulomas in fat-fed immune-competent ApoE knockout and immune-compromised ApoE/Rag-1 double knockout mice, which lack all T and B cells. Furthermore, we performed immunohistochemistry in subcutaneous granulomas and in aortic root and brachiocephalic artery atherosclerotic plaques to measure the extent of M1/M2 marker and MMP protein expression in vivo. Classical activation of mouse macrophages with bacterial lipopolysaccharide in vitro increased MMPs-13, -14 and -25 but decreased MMP-19 and TIMP-2 mRNA expressions. Alternative activation with IL-4 increased MMP-19 expression. Foam cells in subcutaneous granulomas expressed all M1/M2 markers and MMPs at ex vivo mRNA and in vivo protein levels, irrespective of Rag-1 genotype. There were also similar percentages of foam cell macrophages carrying M1/M2 markers and MMPs in atherosclerotic plaques from ApoE knockout and ApoE/Rag-1 double knockout mice. Conclusions: Classical and alternative activation leads to distinct MMP expression patterns in mouse macrophages in vitro. M1 and M2 polarization in vivo occurs in the absence of T and B lymphocytes in either granuloma or plaque foam cell macrophages.

  20. Attributional Gender Bias: Teachers&apos; Ability and Effort Explanations for Students&apos; Math Performance

    Science.gov (United States)

    Espinoza, Penelope; Arêas da Luz Fontes, Ana B.; Arms-Chavez, Clarissa J.

    2014-01-01

    Research is presented on the attributional gender bias: the tendency to generate different attributions (explanations) for female versus male students&apos; performance in math. Whereas boys&apos; successes in math are attributed to ability, girls&apos; successes are attributed to effort; conversely, boys&apos; failures in math are attributed to a…

  1. Treatment of male varicoceles by transcatheter polidocanol foam sclerotherapy: evaluation of clinical success, complications, and patients&apos; satisfaction with regard to alternative techniques

    Energy Technology Data Exchange (ETDEWEB)

    Ali, Alma; Wirth, Stefan; Treitl, Karla Maria; Treitl, Marcus [Hospital of the Ludwig-Maximilians University of Munich, Institute for Clinical Radiology, Munich (Germany)

    2015-10-15

    We report our experience with polidocanol foam sclerotherapy with no additional coils, evaluating clinical success, patients&apos; satisfaction, and complications. We conducted a retrospective study of 141 patients with 146 varicoceles (mean age: 29.3 years; range: 13 - 60 years) who underwent foam sclerotherapy with polidocanol 2 % (range: 2 - 12 ml) in an outpatient setting between January 2007 and December 2013. For the follow-up, telephone interviews with the patients were conducted (mean follow-up time: 46.4 months, standard deviation: 20.17 months). The technical success rate was 91.8 %. There was a 55.8 % response rate to the telephone interviews. Follow-up revealed a clinical success rate of 83.9 % and a persistence or relapse rate of 16.1 %. Of the patients, 81.9 % were absolutely satisfied with the outcome. In 94.9 % of cases, pain or discomfort resolution was reported, and in 97 % of cases, aesthetic issues were no longer a problem. Of partners, 63.2 % achieved pregnancy, and in 50 % of patients with preprocedural testicular atrophy, catch-up growth was observed. One patient with pampiniform plexus phlebitis received inpatient treatment with no long-term damage recorded. Polidocanol foam varicocele sclerotherapy is a safe and effective procedure, with a high rate of patients&apos; satisfaction, clinical and technical success, and considerable catch-up growth and pregnancy achievement. (orig.)

  2. A Case Study of a Male School Principal&apos;s Leadership Practices: An Exploration of Emotion & the Ethic of Care

    Science.gov (United States)

    Myers, Edward L.

    2013-01-01

    This qualitative single-site case study examined the philosophy, decisions, and behaviors of a particular male school principal who subscribed to a form of care-based leadership practice. A Pennsylvania high school principal with a distinct leadership philosophy centered on the ethic of care was chosen to participate in this study. The purpose of…

  3. ApoE and Quality of Life in Nonagenarians

    Science.gov (United States)

    Parsaik, Ajay K; Lapid, Maria I.; Rummans, Teresa A.; Cha, Ruth H.; Boeve, Bradley F.; Pankratz, Vernon (Shane) S.; Tangalos, Eric G.; Petersen, Ronald C.

    2012-01-01

    Objectives ApoE ε4 is associated with adverse health conditions that negatively impact the quality of life (QOL). The relationship between ApoE ε4 and QOL has not been explored in the oldest old. Our study aimed to examine ApoE in the oldest old, and explore its association with QOL. Design Cross-sectional cohort study. Setting A medium sized community in Olmsted County, Minnesota, USA. Participants 90–99 year old individuals living independently or in long term care environments. Measurements We collected demographic information and measured cognitive function (Short Test of Mental Status [STMS], Mini-Mental State Examination [MMSE], Mattis Dementia Rating Scale [DRS]), QOL (Linear Analogue Self Assessment [LASA]) and ApoE distribution. Subjects were classified as cognitively normal, mild cognitive impairment (MCI), dementia (DEM), or dementia with stroke and/or parkinsonism (DEMSP). Regression model was used to assess the predictors of QOL. Results 121 subjects (45 cognitively normal, 13 MCI, 34 DEM, 29 DEMSP) aged 90–99,106 (87.6 %) females, were included. Frequency of ApoE ε3 allele was highest [194 (80.2%): ε2/3 18, ε3/3 77, ε3/4 22] followed by ApoE ε4 [25 (10.3%): ε2/4 3, ε3/4 22] and ApoE ε2 [23 (9.5%; ε2/2 1, ε2/3 18, ε2/4 3]. None of the subjects carried ApoE ε4/4 genotype. QOL was similar between ApoE ε4 carrier and non-carriers. Physical well-being, emotional well-being, intellectual well-being, social connectedness and coping ability were positively associated with QOL, whereas male gender, DEMSP, pain frequency and pain severity were negatively associated. Conclusions The most common ApoE in the oldest old was ε3/3 genotype and ε3 allele. No association was found between ApoE ε4 and QOL. However, those with high physical, emotional and intellectual well being, social connectedness and coping ability had the highest overall QOL. PMID:22863665

  4. Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice.

    Science.gov (United States)

    Klein, Rebecca C; Acheson, Shawn K; Mace, Brian E; Sullivan, Patrick M; Moore, Scott D

    2014-09-01

    The human APOE4 allele is associated with an early age of onset and increased risk of Alzheimer's disease (AD). Apolipoprotein E is secreted as part of a high-density lipoprotein-like particle by glial cells in the brain for the primary purpose of transport of lipophilic compounds involved in the maintenance of synapses. Previous studies examining synaptic integrity in the amygdala of human apoE targeted replacement (TR) mice showed a decrease in spontaneous excitatory synaptic activity, dendritic arbor, and spine density associated with apoE4 compared with apoE3 and apoE2 in adult male mice. In the present study, we assessed how APOE genotype affects synaptic integrity of amygdala neurons by comparing electrophysiological and morphometric properties in human apoE3, E4, and E2/4 TR mice at the age of 18-20 months. In contrast to adult mice, we found that aged apoE4 TR mice exhibited the highest level of excitatory synaptic activity compared with other cohorts. Additionally, apoE4 mice had significantly greater spontaneous inhibitory activity than all other cohorts. Taken together, there was a significant interaction between genotypes when comparing inhibition relative to excitation; there was a simple main effect of frequency type with an imbalance toward inhibition in apoE4 mice but not in apoE3 or apoE2/4 mice. These results suggest that apoE isoforms differentially influence synaptic transmission throughout the life span, where aging coupled with apoE4 expression, results in an imbalance in maintaining integrity of synaptic transmission.

  5. Probing Mechanisms for Inverse Correlation between Rate Performance and Capacity in K-O2 Batteries.

    Science.gov (United States)

    Xiao, Neng; Ren, Xiaodi; He, Mingfu; McCulloch, William D; Wu, Yiying

    2017-02-08

    Owing to the formation of potassium superoxide (K(+) + O2 + e(-) = KO2), K-O2 batteries exhibit superior round-trip efficiency and considerable energy density in the absence of any electrocatalysts. For further improving the practical performance of K-O2 batteries, it is important to carry out a systematic study on parameters that control rate performance and capacity to comprehensively understand the limiting factors in superoxide-based metal-oxygen batteries. Herein, we investigate the influence of current density and oxygen diffusion on the nucleation, growth, and distribution of potassium superoxide (KO2) during the discharge process. It is observed that higher current results in smaller average sizes of KO2 crystals but a larger surface coverage on the carbon fiber electrode. As KO2 grows and covers the cathode surface, the discharge will eventually end due to depletion of the oxygen-approachable electrode surface. Additionally, higher current also induces a greater gradient of oxygen concentration in the porous carbon electrode, resulting in less efficient loading of the discharge product. These two factors explain the observed inverse correlation between current and capacity of K-O2 batteries. Lastly, we demonstrate a reduced graphene oxide-based K-O2 battery with a large specific capacity (up to 8400 mAh/gcarbon at a discharge rate of 1000 mA/gcarbon) and a long cycle life (over 200 cycles).

  6. Characterization of the insulin sensitivity of ghrelin receptor KO mice using glycemic clamps

    Directory of Open Access Journals (Sweden)

    Morgan Kristen

    2011-01-01

    Full Text Available Abstract Background We and others have demonstrated previously that ghrelin receptor (GhrR knock out (KO mice fed a high fat diet (HFD have increased insulin sensitivity and metabolic flexibility relative to WT littermates. A striking feature of the HFD-fed GhrR KO mouse is the dramatic decrease in hepatic steatosis. To characterize further the underlying mechanisms of glucose homeostasis in GhrR KO mice, we conducted both hyperglycemic (HG and hyperinsulinemic-euglycemic (HI-E clamps. Additionally, we investigated tissue glucose uptake and specifically examined liver insulin sensitivity. Results Consistent with glucose tolerance-test data, in HG clamp experiments, GhrR KO mice showed a reduction in glucose-stimulated insulin release relative to WT littermates. Nevertheless, a robust 1st phase insulin secretion was still achieved, indicating that a healthy β-cell response is maintained. Additionally, GhrR KO mice demonstrated both a significantly increased glucose infusion rate and significantly reduced insulin requirement for maintenance of the HG clamp, consistent with their relative insulin sensitivity. In HI-E clamps, both LFD-fed and HFD-fed GhrR KO mice showed higher peripheral insulin sensitivity relative to WT littermates as indicated by a significant increase in insulin-stimulated glucose disposal (Rd, and decreased hepatic glucose production (HGP. HFD-fed GhrR KO mice showed a marked increase in peripheral tissue glucose uptake in a variety of tissues, including skeletal muscle, brown adipose tissue and white adipose tissue. GhrR KO mice fed a HFD also showed a modest, but significant decrease in conversion of pyruvate to glucose, as would be anticipated if these mice displayed increased liver insulin sensitivity. Additionally, the levels of UCP2 and UCP1 were reduced in the liver and BAT, respectively, in GhrR KO mice relative to WT mice. Conclusions These results indicate that improved glucose homeostasis of GhrR KO mice is

  7. Phasic oscillations of extracellular potassium (K(o in pregnant rat myometrium.

    Directory of Open Access Journals (Sweden)

    Roger C Young

    Full Text Available K-sensitive microelectrodes were used to measure K(+ within the extracellular space (K(o of pregnant rat myometrium. Contractile activity was monitored by measuring either force or bioelectrical signals. Single and double-barreled electrodes were used. Double-barreled electrodes allowed monitoring of electrical activity 15 microns from the site of K(o measurement. From double-barreled electrode experiments, the bioelectrical burst started first, and then K(o began to rise 0.6 ± 0.1 seconds later. This delay indicates that K(+ leaves the cells in response to local electrical activity rather than vice versa. Four control experiments were performed to assess the influence of electrical artifacts caused by tissue motion on K(o values. When observed, artifacts were negative and transient, and hence would result in an underestimation of K(o rises. Artifacts were minimized when tissue motion was minimized by fixing the tissue at both ends. At 37°C, 7 single barreled experiments and 45 contractions were analyzed. Resting K(o was within 1 mM of bath K(+ (5 mM at the beginning and end of the experiments. K(o rose during the contraction, fell after the completion of the contraction, and normalized before the next contraction began. Peak K(o values observed during force production were 18.8 ± 5.9 mM, a value high enough to modulate tissue-level electrical activity. K(o required 15.7 ± 2.8 seconds to normalize halfway (t50. Six experiments expressing 38 contractions were performed at 24°C. The contraction period was longer at 24°C. Values for peak K(o (26.2 ± 9.9 mM and t50 (29.8±16.2 sec were both larger than at 37°C (p<0.0003 for both. The direct relationships between peak K(o, t50 and the contraction period, suggest elevations in K(o may modulate contraction frequency. The myometrial interstitial space appears to be functionally important, and K(o metabolism may participate in cell-cell interactions.

  8. Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory.

    Science.gov (United States)

    Biundo, Fabrizio; Ishiwari, Keita; Del Prete, Dolores; D'Adamio, Luciano

    2015-12-01

    Mutations in Amyloid β Precursor Protein (APP) and in genes that regulate APP processing--such as PSEN1/2 and ITM2b/BRI2--cause familial dementia, such Familial Alzheimer disease (FAD), Familial Danish (FDD) and British (FBD) dementias. The ApoE gene is the major genetic risk factor for sporadic AD. Three major variants of ApoE exist in humans (ApoE2, ApoE3, and ApoE4), with the ApoE4 allele being strongly associated with AD. ITM2b/BRI2 is also a candidate regulatory node genes predicted to mediate the common patterns of gene expression shared by healthy ApoE4 carriers and late-onset AD patients not carrying ApoE4. This evidence provides a direct link between ITM2b/BRI2 and ApoE4. To test whether ApoE4 and pathogenic ITM2b/BRI2 interact to modulate learning and memory, we crossed a mouse carrying the ITM2b/BRI2 mutations that causes FDD knocked-in the endogenous mouse Itm2b/Bri2 gene (FDDKI mice) with human ApoE3 and ApoE4 targeted replacement mice. The resultant ApoE3, FDDKI/ApoE3, ApoE4, FDDKI/ApoE4 male mice were assessed longitudinally for learning and memory at 4, 6, 12, and 16-17 months of age. The results showed that ApoE4-carrying mice displayed spatial working/short-term memory deficits relative to ApoE3-carrying mice starting in early middle age, while long-term spatial memory of ApoE4 mice was not adversely affected even at 16-17 months, and that the FDD mutation impaired working/short-term spatial memory in ApoE3-carrying mice and produced impaired long-term spatial memory in ApoE4-carrying mice in middle age. The present results suggest that the FDD mutation may differentially affect learning and memory in ApoE4 carriers and non-carriers.

  9. The first Koç Han: Pioneering modern architecture in Ankara

    Directory of Open Access Journals (Sweden)

    Oya Atalay Franck

    2013-01-01

    Full Text Available Koç Holding is the most established conglomerate in Turkey. Th e company’s beginnings date from the mid 1920s, when Ahmet Vehbi Koç, founder of Koç Holding, had his first own company registered with the Ankara Chamber of Commerce. In 1932, Koç moved his business from his father’s store on Anafartalar Street to a new building, the first Koç Han, erected the same year on Çankırı Street Nr.13 in Ulus. Th e building’s designer was Swiss-Austrian architect Ernst Arnold Egli, who had come to Turkey only five years earlier upon invitation by the government to work as chief architect of the Ministry of National Education. During his stay, which lasted from 1927 until 1940, Egli realized about 40 projects and worked on many more. Koç Han is the rare example of a commercial building by Egli. At a time when the urban aspect of the old town center of Ankara consisted mostly of one-or two-storeyed stone-and-wood houses, the first Koç Han represented an altogether new building type for the town, in being a multipurpose edifice with space for shops at street level, with large storage facilities below ground, and providing off ices and housing on the upper fl oors. Th e functional rigor of the plan and the sober modernism of the building’s facades contrasted strongly with the architecture of the time. In this respect, the first Koç Han was a strong statement regarding Ahmet Vehbi Koç’s belief in a modern Turkey and to the contribution of the building’s architect, Ernst Arnold Egli, to this project.

  10. The strategic &apos;'pull'&apos; and operational &apos;'push'&apos; of total quality management in UK regional electricity service companies

    Energy Technology Data Exchange (ETDEWEB)

    McAdam, R.; McLean, J.; Henderson, J.

    2003-04-30

    The aim of this paper is to evaluate whether the UK regional electricity companies (RECs) has used total quality management (TQM) as a &apos;'push'&apos; or as a &apos;'pull'&apos; change methodology. &apos;'Push'&apos; is the operational improvement role of TQM; &apos;'pull'&apos; is the strategic or direction giving, improvement role of TQM. Following the onset of privatisation in 1990 there has been evidence of the RECs adopting TQM in both &apos;'push'&apos; and &apos;'pull'&apos; methodologies with varying degrees of success. An evaluation of the change processes involved will enable improved change models to be developed leading to increased business effectiveness in this 30 billion pounds sterling industry. Other possible benefits include the possible generalisations to other utilities such as water, roads, gas and telecoms. The research methodology includes a comparative case study analysis of five RECs, which have used TQM as their overarching approach to change. One of the cases is analysed to a more in-depth level based on the multiple case findings. The findings indicate that the &apos;'push-pull'&apos; analysis enables the full range of TQM activities to be evaluated in the RECs studied. Overall, there is a need to have a balanced portfolio of operational or &apos;'push'&apos;-based TQM activity that is driven by strategic or &apos;'pull'&apos; based TQM planning and activity. (author)

  11. Mixed municipal solid waste (MSW) treatment in Waste centre Spodnji Stari Grad, Krško

    OpenAIRE

    Kortnik, Jože; Leskovar, Jože

    2015-01-01

    Review paper Received: October 25, 2013 Accepted: November 7, 2013 Mixed municipal solid waste (MSW) treatment in Waste centre Spodnji Stari Grad, Krško Ravnanje z mešanimi komunalnimi odpadki v Zbirnem centru Spodnji Stari Grad, Krško Jože Kortnik1'*, Jože Leskovar2 University of Ljubljana, Faculty of Natural Sciences and Engineering, Department of Mining and Geotechnology, Aškerčeva 12, 1000 Ljubljana, Slovenia 2Kostak, d. d., Leskovška cesta 2a, 8270 Krško, Slovenia Correspo...

  12. ApoER2 Function in the Establishment and Maintenance of Retinal Synaptic Connectivity

    Science.gov (United States)

    Trotter, Justin H.; Klein, Martin; Jinwal, Umesh K.; Abisambra, Jose F.; Dickey, Chad A.; Tharkur, Jeremy; Masiulis, Irene; Ding, Jindong; Locke, Kirstin G.; Rickman, Catherine Bowes; Birch, David G.; Weeber, Edwin J.; Herz, Joachim

    2011-01-01

    The cellular and molecular mechanisms responsible for the development of inner retinal circuitry are poorly understood. Reelin and apolipoprotein E (apoE), ligands of apoE receptor 2 (ApoER2), are involved in retinal development and degeneration, respectively. Here we describe the function of ApoER2 in the developing and adult retina. ApoER2 expression was highest during postnatal inner retinal synaptic development and was considerably lower in the mature retina. Both during development and in the adult ApoER2 was expressed by A-II amacrine cells. ApoER2 knockout (KO) mice had rod bipolar morphogenic defects, altered A-II amacrine dendritic development, and impaired rod-driven retinal responses. The presence of an intact ApoER2 NPxY motif, necessary for binding disabled-1 (Dab1) and transducing the Reelin signal, was also necessary for development of the rod bipolar pathway while the alternatively-spliced exon19 was not. Mice deficient in another Reelin receptor, very low-density lipoprotein receptor (VLDLR), had normal rod bipolar morphology but altered A-II amacrine dendritic development. VLDLR KO mice also had reductions in oscillatory potentials and delayed synaptic response intervals. Interestingly, age-related reductions in rod and cone function were observed in both ApoER2 and VLDLR KOs. These results support a pivotal role for ApoER2 in the establishment and maintenance of normal retinal synaptic connectivity. PMID:21976526

  13. Hydrochemical and isotope groundwater investigations in Sorško polje

    Directory of Open Access Journals (Sweden)

    Brigita Jamnik

    2008-06-01

    Full Text Available From the hydrogeological point of view Sorško polje area is a sink, filled with conglomerate,sandand gravel,where large quantities of groundwater are accumulated. Sorško polje aquifer is one of the richest regions of groundwater and represents an important reserve water source for the central part of Slovenia.The performed hydrochemical and isotope investigations present an independent completion of the previous hydrogeological investigation of Sorško polje. The results of research give more reliable information about the water origin, as well as about the influence of the local precipitation and Sava river water on the dynamics of the groundwater restoration in the aquifer. The research defines the characteristics of oxygen isotop ecomposition of groundwater in the Sorško polje aquifer and determines the volume share of aquifer recharge from the Sava river and from local precipitation.

  14. Cellular chloride and bicarbonate retention alters intracellular pH regulation in Cftr KO crypt epithelium.

    Science.gov (United States)

    Walker, Nancy M; Liu, Jinghua; Stein, Sydney R; Stefanski, Casey D; Strubberg, Ashlee M; Clarke, Lane L

    2016-01-15

    Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR), an anion channel providing a major pathway for Cl(-) and HCO3 (-) efflux across the apical membrane of the epithelium. In the intestine, CF manifests as obstructive syndromes, dysbiosis, inflammation, and an increased risk for gastrointestinal cancer. Cftr knockout (KO) mice recapitulate CF intestinal disease, including intestinal hyperproliferation. Previous studies using Cftr KO intestinal organoids (enteroids) indicate that crypt epithelium maintains an alkaline intracellular pH (pHi). We hypothesized that Cftr has a cell-autonomous role in downregulating pHi that is incompletely compensated by acid-base regulation in its absence. Here, 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein microfluorimetry of enteroids showed that Cftr KO crypt epithelium sustains an alkaline pHi and resistance to cell acidification relative to wild-type. Quantitative real-time PCR revealed that Cftr KO enteroids exhibit downregulated transcription of base (HCO3 (-))-loading proteins and upregulation of the basolateral membrane HCO3 (-)-unloader anion exchanger 2 (Ae2). Although Cftr KO crypt epithelium had increased Ae2 expression and Ae2-mediated Cl(-)/HCO3 (-) exchange with maximized gradients, it also had increased intracellular Cl(-) concentration relative to wild-type. Pharmacological reduction of intracellular Cl(-) concentration in Cftr KO crypt epithelium normalized pHi, which was largely Ae2-dependent. We conclude that Cftr KO crypt epithelium maintains an alkaline pHi as a consequence of losing both Cl(-) and HCO3 (-) efflux, which impairs pHi regulation by Ae2. Retention of Cl(-) and an alkaline pHi in crypt epithelium may alter several cellular processes in the proliferative compartment of Cftr KO intestine.

  15. Building a terminology network for search: the KoMoHe project

    CERN Document Server

    Mayr, Philipp

    2008-01-01

    The paper reports about results on the GESIS-IZ project "Competence Center Modeling and Treatment of Semantic Heterogeneity" (KoMoHe). KoMoHe supervised a terminology mapping effort, in which 'cross-concordances' between major controlled vocabularies were organized, created and managed. In this paper we describe the establishment and implementation of cross-concordances for search in a digital library (DL).

  16. Enhanced ethanol fermentation of brewery wastewater using the genetically modified strain E. coli KO11.

    Science.gov (United States)

    Rao, Kripa; Chaudhari, Vaibhav; Varanasi, Sasidhar; Kim, Dong-Shik

    2007-02-01

    We have used liquid waste obtained from a beer brewery process to produce ethanol. To increase the productivity, genetically modified organism, Escherichia coli KO11, was used for ethanol fermentation. Yeast was also used to produce ethanol from the same feed stock, and the ethanol production rates and resulting concentrations of sugars and ethanol were compared with those of KO11. In the experiments, first the raw wastewater was directly fermented using two strains with no saccharification enzymes added. Then, commercial enzymes, alpha-amylase, pectinase, or a combination of both, were used for simultaneous saccharification and fermentation, and the results were compared with those of the no-enzyme experiments for KO11 and yeast. Under the given conditions with or without the enzymes, yeast produced ethanol more rapidly than E. coli KO11, but the final ethanol concentrations were almost the same. For both yeast and KO11, the enzymes were observed to enhance the ethanol yields by 61-84% as compared to the fermentation without enzymes. The combination of the two enzymes increased ethanol production the most for the both strains. The advantages of using KO11 were not demonstrated clearly as compared to the yeast fermentation results.

  17. High energy X-ray laboratory &apos;'HEXYLab'&apos;. The new facility &apos;'HEXYTech'&apos;; Hochenergie-Roentgen-Labor &apos;'HEXYLab'&apos;. Die neue Anlage &apos;'HEXYTech'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Redmer, Bernhard; Hohendorf, Stefan; Kolkoori, Sanjeevareddy; Wrobel, Norma; Ewert, Uwe [BAM Bundesanstalt fuer Materialforschung und -pruefung, Berlin (Germany)

    2015-07-01

    High-energy radiography is used traditionally for the detection of defects in the thick-walled, bulky components. It is also used for testing the integrity of components for civil and security related applications (containers). The combination of high-energy emitters with digital detector arrays or line cameras allows test procedures in a shorter time compared to film or higher contrast sensitivity. The high-energy X-ray laboratory HEXYLab BAM is a joint laboratory in which future users, manufacturers and scientists can initiate and develop joint development projects. The new universal manipulation system HEXYTech forms the engineering and technical base for the most diverse requirements in HEXYLab (High Energy X-raY Lab.). With a total of 13 rotary and linear axes the diverse trajectories for tube, object and detector can be programmed. So large objects with complex geometries can be examined. 2D and 3D images can be measured by simple radiography, and laminography and computed tomography. The general rules for the application of high energy radiography with digital detectors (imaging plates, Digital detector arrays) were determined within the framework of the European project &apos;'HEDRad'&apos; (High Energy Digital Radiography) and included in the standard DIN EN ISO 17636-2. This article gives an overview of the testing technology and presents the possible applications on the basis of images and experiments. (PowerPoint slides). [German] Hochenergie-Radiographie wird traditionell fuer die Detektion von Defekten in dickwandigen, sperrigen Komponenten angewendet. Sie wird auch genutzt fuer die Pruefung der Komponentenintegritaet bei zivilen und sicherheitsrelevanten Anwendungen (Container). Die Kombination von Hochenergie- Strahlern mit digitalen Detektorarrays oder Zeilenkameras ermoeglicht die Pruefungsdurchfuehrung in kuerzerer Zeit im Vergleich zum Film oder mit hoeherer Kontrastempfindlichkeit. Das Hochenergie-Roentgen-Labor &apos;'HEXYLab'&apos

  18. Apolipoprotein A-I inhibits LPS-induced atherosclerosis in ApoE-/-mice possibly via activated STAT3-mediated upregulation of tristetraprolin

    Institute of Scientific and Technical Information of China (English)

    Kai YIN; Shi-lin TANG; Xiao-hua YU; Guang-hui TU; Rong-fang HE; Jin-feng LI; Di XIE

    2013-01-01

    Aim:To investigate the effects of the major component of high-density lipoprotein apolipoprotein A-I (apoA-I) on the development of atherosclerosis in LPS-challenged ApoE-/-mice and the underlying mechanisms.Methods:Male ApoE-KO mice were daily injected with LPS (25 μg,sc) or PBS for 4 weeks.The LPS-challenged mice were intravenously injected with rAAV-apoA-I-GFP or rAAV-GFP.After the animals were killed,blood,livers and aortas were collected for biochemical and histological analyses.For ex vivo experiments,the abdominal cavity macrophages were harvested from each treatment group of mice,and cultured with autologous serum,then treated with LPS.Results:Chronic administration of LPS in ApoE-/-mice significantly increased the expression of inflammatory cytokines (TNF-α,IL-1β,IL-6,and MCP-1),increased infiltration of inflammatory cells,and enhanced the development of atherosclerosis.In LPS-challenged mice injected with rAAV-apoA-I-GFP,viral particles and human apoA-I were detected in the livers,total plasma human apoA-I levels were grammatically increased; HDL-cholesterol level was significantly increased,TG and TC were slightly increased.Furthermore,overexpression of apoA-l significantly suppressed the expression of proinflammatory cytokines,reduced the infiltration of inflammatory cells,and decreased the extent of atherosclerotic lesions.Moreover,overexpression of apoA-I significantly increased the expression of the cytokine mRNA-destabilizing protein tristetraprolin (TTP),and phosphorylation of JAK2 and STAT3 in aortas.In ex vivo mouse macrophages,the serum from mice overexpressing apoA-I significantly increased the expression of TTP,accompanied by accelerated decay of mRNAs of the inflammatory cytokines.Conclusion:ApoA-I potently suppresses LPS-induced atherosclerosis by inhibiting the inflammatory response possibly via activation of STAT3 and upregulation of TTP.

  19. Examining the interaction of apo E and neurotoxicity on a murine model of ALS-PDC.

    Science.gov (United States)

    Wilson, J M B; Petrik, M S; Moghadasian, M H; Shaw, C A

    2005-02-01

    Epidemiological studies have shown a positive relationship between cycad flour consumption and the development of the neurodegenerative disorder, amyotrophic lateral sclerosis - parkinsonism - dementia complex (ALS-PDC). Apolipoprotein E (apo E) allele variations have been associated with genetic susceptibility in neurodegenerative diseases, including ALS-PDC. We have studied cycad toxicity in a mouse model of ALS-PDC with a particular interest in its impact on the central nervous system (CNS) in both apo E knock-out (KO) mice and their wild-type (WT) counterparts. Behavioral motor tests, motor neuron counts, and immunohistochemical staining in brain and spinal cord, as well as routine histological examinations on internal organs, were performed to evaluate cycad toxicity. Plasma cholesterol levels were also measured before and during the study. Cycad treatment was associated with higher levels of plasma cholesterol only in apo E KO mice; increased levels of plasma cholesterol did not result in increased athero genesis. Cycad-fed wild-type mice developed progressive behavioral deficits including ALS-PDC-like pathological outcomes, while cycad-fed apo E KO mice were not significantly affected. Cycad-fed wild-type mice had shorter gait length measurements along with higher active caspase-3 levels in the striatum, substantia nigra, primary motor cortex, and spinal cord as compared with corresponding controls. These changes were associated with decreased labeling for glutamate transporter 1B and tyrosine hydroxylase activity levels. No evidence of cycad toxicity was observed in internal organs of either wild-type or apo E KO mice. Our data demonstrate that apo E KO mice are less susceptible to cycad toxicity, suggesting a role for apo E as a possible genetic susceptibility factor for some forms of toxin-induced neurodegeneration.

  20. Oil protection &apos;&apos;John R&apos;&apos;; Oljevernaksjon &apos;&apos;John R&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    The report briefly reviews the emergency actions after the bulk ship &apos;&apos;John R&apos;&apos; ran aground off Troms on December 15, 2002. The report was worked out by the contingency and control division at the National State Pollution Control Authority (SFT). SFT mobilized their own action organization to attend to the oil pollution preparedness around the disabled ship. The Norwegian Directorate of Shipping and Navigation (SD) mobilized in order to attend to a possible emergency discharging of the ship. In the opening phase, the situation was handled by Defence Command North Norway. The report is built on logs and other written documentation from the Coast Guard and from SFT. Material from several other participants are also included. The harmful effects on the environment were kept to a minimum. Altogether oil damage was observed on 1300 - 1800 sea birds. Only minor shores in three areas were affected.

  1. AHNAK KO mice are protected from diet-induced obesity but are glucose intolerant.

    Science.gov (United States)

    Ramdas, M; Harel, C; Armoni, M; Karnieli, E

    2015-04-01

    AHNAK is a 700 KD phosphoprotein primarily involved in calcium signaling in various cell types and regulating cytoskeletal organization and cell membrane architecture. AHNAK expression has also been associated with obesity. To investigate the role of AHNAK in regulating metabolic homeostasis, we studied whole body AHNAK knockout mice (KO) on either regular chow or high-fat diet (HFD). KO mice had a leaner phenotype and were resistant to high-fat diet-induced obesity (DIO), as reflected by a reduction in adipose tissue mass in conjunction with higher lean mass compared to wild-type controls (WT). However, KO mice exhibited higher fasting glucose levels, impaired glucose tolerance, and diminished serum insulin levels on either diet. Concomitantly, KO mice on HFD displayed defects in insulin signaling, as evident from reduced Akt phosphorylation and decreased cellular glucose transporter (Glut4) levels. Glucose intolerance and insulin resistance were also associated with changes in expression of genes regulating fat, glucose, and energy metabolism in adipose tissue and liver. Taken together, these data demonstrate that (a) AHNAK is involved in glucose homeostasis and weight balance (b) under normal feeding KO mice are insulin sensitive yet insulin deficient; and (c) AHNAK deletion protects against HFD-induced obesity, but not against HFD-induced insulin resistance and glucose intolerance in vivo.

  2. Longitudinal Links between Fathers&apos; and Mothers&apos; Harsh Verbal Discipline and Adolescents&apos; Conduct Problems and Depressive Symptoms

    Science.gov (United States)

    Wang, Ming-Te; Kenny, Sarah

    2014-01-01

    This study used cross-lagged modeling to examine reciprocal relations between maternal and paternal harsh verbal discipline and adolescents&apos; conduct problems and depressive symptoms. Data were from a sample of 976 two-parent families and their children (51% males; 54% European American, 40% African American). Mothers&apos; and fathers&apos;…

  3. The founder of the church of Saint George at Pološko

    Directory of Open Access Journals (Sweden)

    Pavlović Dragana

    2015-01-01

    Full Text Available The paper seeks to establish who was the founder of the church of Saint George at Pološko and revise the conclusions of previous researchers regarding this issue. According to the opinion commonly adopted in the scholarly literature, Jovan Dragušin, a cousin of King Dušan, had merely undertaken the construction of church at Pološko, whereas his mother was responsible for the completion of construction and painting of frescoes in the church. Through an analysis of written and visual sources the conclusion is reached that the sole person responsible for the construction and painting of the church at Pološko was the nun Maria, the mother of Jovan Dragušin. [Projekat Ministarstva nauke Republike Srbije, br. 177036: Srpska srednjovekovna umetnost i njen evropski kontekst

  4. Poland&apos;s syndrome: radiologic findings

    Energy Technology Data Exchange (ETDEWEB)

    Bazzi Junior, Joao Lourenco, E-mail: joaobazzijr@gmail.com [Clinica Via Imagem, Xanxere, SC (Brazil); Matta, Eduardo Simoes da [Pro Circulacao - Clinica de Angiologia, Cirurgia Vascular e Ecografia Vascular, Xanxere, SC (Brazil); De Bortoli, Luciano [Materclinica Materno Infantil, Xanxere, SC (Brazil); De Bortoli, Felipe Raasch [Universidade Catolica de Pelotas (UCPel), Pelotas, RS (Brazil). Fac. of Medicine

    2012-05-15

    Poland&apos;s syndrome is a rare non-inherited congenital anomaly. The authors describe the classic radiologic findings of Poland&apos;s syndrome by reporting the case of a male four-year old patient with asymmetry of hands and chest, illustrating the fundamental imaging criteria for a conclusive diagnosis. (author)

  5. Mas receptor deficiency is associated with worsening of lipid profile and severe hepatic steatosis in ApoE-knockout mice.

    Science.gov (United States)

    Silva, Analina R; Aguilar, Edenil C; Alvarez-Leite, Jacqueline I; da Silva, Rafaela F; Arantes, Rosa M E; Bader, Michael; Alenina, Natalia; Pelli, Graziano; Lenglet, Sébastien; Galan, Katia; Montecucco, Fabrizio; Mach, François; Santos, Sérgio H S; Santos, Robson A S

    2013-12-01

    The classical renin-angiotensin system pathway has been recently updated with the identification of additional molecules [such as angiotensin converting enzyme 2, ANG-(1-7), and Mas receptor] that might improve some pathophysiological processes in chronic inflammatory diseases. In the present study, we focused on the potential protective role of Mas receptor activation on mouse lipid profile, liver steatosis, and atherogenesis. Mas/apolipoprotein E (ApoE)-double-knockout (DKO) mice (based on C57BL/6 strain of 20 wk of age) were fed under normal diet and compared with aged-matched Mas and ApoE-single-knockout (KO), as well as wild-type mice. Mas/ApoE double deficiency was associated with increased serum levels of atherogenic fractions of cholesterol, triglycerides, and fasting glucose compared with wild-type or single KO. Serum levels of HDL or leptin in DKO were lower than in other groups. Hepatic lipid content as well as alanine aminotransferase serum levels were increased in DKO compared with wild-type or single-KO animals. Accordingly, the hepatic protein content of mediators related to atherosclerotic inflammation, such as peroxisome proliferator-activated receptor-α and liver X receptor, was altered in an adverse way in DKO compared with ApoE-KO. On the other hand, DKO mice did not display increased atherogenesis and intraplaque inflammation compared with ApoE-KO group. In conclusion, Mas deletion in ApoE-KO mice was associated with development of severe liver steatosis and dyslipidemia without affecting concomitant atherosclerosis. Mas receptor activation might represent promising strategies for future treatments targeting both hepatic and metabolic alterations in chronic conditions clustering these disorders.

  6. KITAJSKA, PRILOŽNOST ALI TVEGANJE ZA NEMŠKO AVTOMOBILSKO INDUSTRIJO - PRIMER BMW

    OpenAIRE

    Grmek, Tine

    2014-01-01

    Nemška avtomobilska industrija je zelo pomembna za nemško gospodarstvo in zaposlovanje. Pomembni avtomobilski trgi za nemško avtomobilsko industrijo so poleg evropskega in ameriškega, še kitajski. Kitajska ima visoko gospodarsko rast in z njo se povečuje tudi povpraševanje po avtomobilih. Večina kitajskih proizvajalcev avtomobilov je v državni lasti. Ker kitajskim proizvajalcev manjkajo izkušnje, se združujejo v »Joint Venture« z mednarodnimi proizvajalci vozil. Kitajski trg ima vedno večjo k...

  7. Advanced RF-KO slow-extraction method for the reduction of spill ripple

    CERN Document Server

    Noda, K; Shibuya, S; Uesugi, T; Muramatsu, M; Kanazawa, M; Takada, E; Yamada, S

    2002-01-01

    Two advanced RF-knockout (RF-KO) slow-extraction methods have been developed at HIMAC in order to reduce the spill ripple for accurate heavy-ion cancer therapy: the dual frequency modulation (FM) method and the separated function method. As a result of simulations and experiments, it was verified that the spill ripple could be considerably reduced using these advanced methods, compared with the ordinary RF-KO method. The dual FM method and the separated function method bring about a low spill ripple within standard deviations of around 25% and of 15% during beam extraction within around 2 s, respectively, which are in good agreement with the simulation results.

  8. DIGITALNO MARKETINŠKO KOMUNICIRANJE V PODJETJU SIMOBIL D.D.

    OpenAIRE

    Cajnko, Katja

    2015-01-01

    Digitalni marketing oz. marketinško komuniciranje je relativno nov tehnološki izraz, ki je izbruhnil v svet industrije. Opredelimo ga lahko kot promocijsko izpostavljenost izdelkov ali svetovnih blagovnih znamk skozi eno ali več oblik družbenega mreženja. Povzroča pravi gospodarski razcvet, medtem ko so tradicionalne marketinške metode postale manj dobičkonosne in zastarele ter se v veliki večini osredinjajo samo na televizijske in časopisne oglase. Njegov obstoj ne gre jemati kot luksuzen...

  9. On the origin and evolutionary state of RZ Cas, KO Aql and S Equ

    CERN Document Server

    Mennekens, N; Van Rensbergen, W; Yungelson, L R

    2008-01-01

    Aims. Determination of the present evolutionary state and the restrictions on the initial mass ratios of RZ Cas, KO Aql and S Equ. Methods. Comparison of mass gaining stars with evolutionary models of single stars with the same mass and subsequent comparison with accretion tracks from simultaneous conservative binary evolution. Results. The gainers are in an early main sequence stage (Xc greater than 0.5), with KO Aql being almost unevolved. The initial donor/gainer mass ratios Mdi/Mgi must be larger than three to obtain the present mass and luminosity of the gainers.

  10. Low-dose nicotine facilitates spatial memory in ApoE-knockout mice in the radial arm maze.

    Science.gov (United States)

    Sultana, Ruby; Ameno, Kiyoshi; Jamal, Mostofa; Miki, Takanori; Tanaka, Naoko; Ono, Junichiro; Kinoshita, Hiroshi; Nakamura, Yu

    2013-06-01

    Here, we investigated the effects of nicotine on spatial memory in ApoE-knockout (ApoE-KO) and wild-type (WT) mice in a radial arm maze. Training occurred on three consecutive days and the test was performed on day 4, with one trial per day. Then on day 4, animals were administered nicotine (0.1, 0.25, 0.5, and 1.0 mg/kg) or the antagonist of nicotinic receptors (nAChRs) mecamylamine (MEC 2 mg/kg) alone or together with 0.1 mg/kg nicotine. The number of errors in the first eight choices was recorded. The results were that 0.1 mg/kg nicotine decreased errors in ApoE-KO mice, while 0.1 and 0.25 mg/kg nicotine reduced errors in WT mice, indicating that lower doses of nicotine elicit a memory improvement. In contrast, 1.0 mg/kg nicotine increased errors in WT mice, but not in ApoE-KO mice. MEC alone had no noticeable effect on errors in either strain of mice. However, co-administration of 0.1 mg/kg nicotine and MEC increased errors and reduced the effects of nicotine in WT mice, but not in ApoE-KO mice. Our study found a biphasic effect of nicotine in WT mice: it improves spatial memory at lower doses and impairs it at a higher dose. In ApoE-KO mice, nicotine improves memory at a low dose and has no effect at a higher dose, suggesting that the ApoE deficiency may influence the efficacy of nicotine. Moreover, a reversal of nicotinic effects with MEC was seen in WT mice, indicating the likelihood of the involvement of nAChRs in the spatial-memory response to nicotine.

  11. The &apos;'invisible'&apos; radioactive scale

    Energy Technology Data Exchange (ETDEWEB)

    Bjoernstad, T.; Ramsoey, T

    1999-04-01

    Production and up-concentration of naturally occurring radioactive material (NORM) in the petroleum industry has attracted steadily increasing attention during the last 15 years. Most production engineers today associate this radioactivity with precipitates (scales) and sludges in production tubing, pumps, valves, separators, settling tanks etc., wherever water is being transported or treated. {sup 226}Ra and {sup 228}Ra are the most well known radioactive constituents in scale. Surprisingly little known is the radioactive contamination by {sup 210}Pb and progeny {sup 210}Bi and {sup 210}Po. These are found in combination with {sup 226}Ra in ordinary scale, often in layer of non-radioactive metallic lead in water transportation systems, but also in pure gas and condensate handling systems &apos;'unsupported'&apos; by {sup 226}Ra, but due to transportation and decay of the noble gas {sup 222}Rn in NG/LNG. This latter contamination may be rather thin, in some cases virtually invisible. When, in addition, the radiation energies are low enough for not being detectable on the equipment outer surface, its existence has for most people in the industry been a secret. The report discusses transportation and deposition mechanisms, detection methods and provides some examples of measured results from the North Sea on equipment sent for maintenance. It is concluded that a regular measurement program for this type of contamination should be mandatory under all dismantling processes of transportation and fluid handling equipment for fluids and gases offshore and onshore.

  12. Neutrino-gaseous &apos;'pancakes'&apos; and the problem of hidden mass

    Energy Technology Data Exchange (ETDEWEB)

    Doroshkevich, A.G. (AN SSSR, Moscow. Inst. Prikladnoj Matematiki)

    1983-08-01

    Taking into account peculiar velocities of neutrinos the gaseous component is shown to dominate in the central part of a cosmological &apos;'pancake'&apos; (rhosub(p) > rhosub(..nu..)), while on the average anti rhosub(b) << anti rhosub(..nu..). Therefore fragmentation of a gaseous &apos;'pancake'&apos; and later clustering of the fragments into galaxies and groups of galaxies are determined by velocity distribution and gravity of the gaseous component. The hidden mass is formed by capture of neutrinos by clustering clouds. Formation of the cluster of galaxies is connected with perturbations embracing all the neutrino-gaseous &apos;'pancake'&apos;, initial ratio of neutrino-to-gaseous densities being reestablished. It is shown that the first &apos;'pancakes'&apos; were formed at the red shifts z=5-8.

  13. Liver steatosis study_PFAA treated Wild type and PPAR KO mouse data

    Data.gov (United States)

    U.S. Environmental Protection Agency — Data set 1 consists of the experimental data for the Wild Type and PPAR KO animal study and includes data used to prepare Figures 1-4 and Table 1 of the Das et al,...

  14. Öko tähendab edu / Liis Kängsepp

    Index Scriptorium Estoniae

    Kängsepp, Liis, 1981-

    2008-01-01

    Kaubandusturul on populaarsust kogumas mahe- ja ausalt toodetud (fair trade) kaubad. Vt. samas: Mis on mahetoit; Fair Trade; Roheline liikumine: tarbi vähem!; Mätas: pane öko peale ja müüb!; Treener Kristel Tamm jõudis ökoni oma lapsele head pakkuda tahtes

  15. A comprehensive study of distribution laws for the fragments of Ko\\v{s}ice meteorite

    CERN Document Server

    Gritsevich, Maria; Kohout, Tomáš; Tóth, Juraj; Peltoniemi, Jouni; Turchak, Leonid; Virtanen, Jenni

    2014-01-01

    In this study, we conduct a detailed analysis of the Ko\\v{s}ice meteorite fall (February 28, 2010), in order to derive a reliable law describing the mass distribution among the recovered fragments. In total, 218 fragments of the Ko\\v{s}ice meteorite, with a total mass of 11.285 kg, were analyzed. Bimodal Weibull, bimodal Grady and bimodal lognormal distributions are found to be the most appropriate for describing the Ko\\v{s}ice fragmentation process. Based on the assumption of bimodal lognormal, bimodal Grady, bimodal sequential and bimodal Weibull fragmentation distributions, we suggest that, prior to further extensive fragmentation in the lower atmosphere, the Ko\\v{s}ice meteoroid was initially represented by two independent pieces with cumulative residual masses of approximately 2 kg and 9 kg respectively. The smaller piece produced about 2 kg of multiple lightweight meteorite fragments with the mean around 12 g. The larger one resulted in 9 kg of meteorite fragments, recovered on the ground, including the...

  16. Characterization and behavior in the environment of the crude oil &apos;'Prestige'&apos;; Caracterisation et comportement dans l&apos;environnement du fioul &apos;'Prestige'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-03-01

    This study presents analysis realized on the crude oil of the tanker &apos;'Prestige'&apos; which sunk the 19 november 2002. The specifications on the product and its behavior in sea water are detailed. All the analysis are compared to the &apos;'Erika'&apos; crude oil. (A.L.B.)

  17. The adductor magnus &apos;'mini-hamstring'&apos;: MRI appearance and potential pitfalls

    Energy Technology Data Exchange (ETDEWEB)

    Broski, Stephen M.; Murthy, Naveen S.; Collins, Mark S. [Department of Radiology, Mayo Clinic, Rochester, MN (United States); Krych, Aaron J. [Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN (United States); Obey, Mitchel R. [Mayo School of Graduate Medical Education, Rochester, MN (United States)

    2016-02-15

    To examine the anatomic MRI characteristics of the adductor magnus mini hamstring (AMMH) and explore its involvement in cases of hamstring avulsion. An IRB-approved retrospective review of patients undergoing &apos;&apos;hamstring protocol&apos;&apos; MRI between March 2009 and June 2014 was performed. Two musculoskeletal radiologists recorded multiple AMMH anatomic characteristics and involvement in cases of hamstring avulsion. Seventy-six AMMHs were analyzed in 66 patients [35 females and 31 males, mean age 49.3 ± 15.2 years (range 17-81)]. Eleven percent of AMMHs were poorly visualized, 51 % visualized, and 37 % well visualized. Seven percent demonstrated round, 73 % ovoid, and 21 % flat/lenticular tendon morphologies. Most (88 %) demonstrated typical origins. Average cross-sectional area (CSA) was 22.4 ± 10.6 mm{sup 2} (range 6-56), diameter was 7.2 ± 2.5 mm (range 2.9-15), medial distance from the semimembranosus tendon was 7.5 ± 2.5 mm (range 3-14), and tendon length was 6.8 ± 3.3 cm (range 1.2-14.1). There was no gender difference in AMMH anatomic measurements or correlation between age and CSA or diameter. Of 17 complete hamstring avulsion cases, the AMMH was intact in 13, partially torn in 3, and completely torn in 1. The AMMH is a constant finding with variable anatomic characteristics. It is visualized or well visualized by MRI in 88 % of cases and is a sizable tendon located in close proximity to the semimembranosus tendon. Because it is uncommonly completely torn (6 %) in cases of complete hamstring avulsion, radiologists should be aware of its presence and appearance to avoid diagnostic confusion. (orig.)

  18. BLOWIN&apos; IN THE WIND: BOTH &apos;'NEGATIVE'&apos; AND &apos;'POSITIVE'&apos; FEEDBACK IN AN OBSCURED HIGH-z QUASAR

    Energy Technology Data Exchange (ETDEWEB)

    Cresci, G.; Mannucci, F. [INAF-Osservatorio Astrofisco di Arcetri, largo E. Fermi 5, I-50127, Firenze (Italy); Mainieri, V. [European Southern Observatory, Karl-Schwarzschild-strasse 2, D-85748 Garching bei München (Germany); Brusa, M.; Perna, M.; Lanzuisi, G. [Dipartimento di Fisica e Astronomia, Università di Bologna, viale Berti Pichat 6/2, I-40127 Bologna (Italy); Marconi, A. [Dipartimento di Fisica e Astronomia, Università degli Studi di Firenze, via G. Sansone 1, I-50019 Sesto F.no, Firenze (Italy); Piconcelli, E.; Feruglio, C.; Fiore, F.; Bongiorno, A. [INAF-Osservatorio Astronomico di Roma, via Frascati 33, I-00040 Monteporzio Catone (Italy); Maiolino, R. [Cavendish Laboratory, University of Cambridge, 19 J. J. Thomson Avenue, Cambridge (United Kingdom); Merloni, A [Max Planck Institut für Extraterrestrische Physik, Giessenbachstrasse 1, D-85748 Garching bei München (Germany); Schramm, M.; Silverman, J. D. [Kavli Institute for the Physics and Mathematics of the Universe (WPI), Todai Institutes for Advanced Study, the University of Tokyo, Kashiwanoha 5-1-5, Kashiwa-shi, Chiba 277-8568 (Japan); Civano, F., E-mail: gcresci@arcetri.astro.it [Department of Physics and Yale Center for Astronomy and Astrophysics, Yale University, PO Box 208121, New Haven, CT 06520-8121 (United States)

    2015-01-20

    Quasar feedback in the form of powerful outflows is invoked as a key mechanism to quench star formation in galaxies, preventing massive galaxies to overgrow and producing the red colors of ellipticals. On the other hand, some models are also requiring &apos;'positive'&apos; active galactic nucleus feedback, inducing star formation in the host galaxy through enhanced gas pressure in the interstellar medium. However, finding observational evidence of the effects of both types of feedback is still one of the main challenges of extragalactic astronomy, as few observations of energetic and extended radiatively driven winds are available. Here we present SINFONI near infrared integral field spectroscopy of XID2028, an obscured, radio-quiet z = 1.59 QSO detected in the XMM-COSMOS survey, in which we clearly resolve a fast (1500 km s{sup –1}) and extended (up to 13 kpc from the black hole) outflow in the [O III] lines emitting gas, whose large velocity and outflow rate are not sustainable by star formation only. The narrow component of Hα emission and the rest frame U-band flux from Hubble Space Telescope/Advanced Camera for Surveys imaging enable to map the current star formation in the host galaxy: both tracers independently show that the outflow position lies in the center of an empty cavity surrounded by star forming regions on its edge. The outflow is therefore removing the gas from the host galaxy (&apos;&apos;negative feedback&apos;&apos;), but also triggering star formation by outflow induced pressure at the edges (&apos;&apos;positive feedback&apos;&apos;). XID2028 represents the first example of a host galaxy showing both types of feedback simultaneously at work.

  19. &apos;&apos;When Cost Measures Contradict&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Montgomery, W. D.; Smith, A. E.; Biggar, S. L.; Bernstein, P. M.

    2003-05-09

    When regulators put forward new economic or regulatory policies, there is a need to compare the costs and benefits of these new policies to existing policies and other alternatives to determine which policy is most cost-effective. For command and control policies, it is quite difficult to compute costs, but for more market-based policies, economists have had a great deal of success employing general equilibrium models to assess a policy&apos;s costs. Not all cost measures, however, arrive at the same ranking. Furthermore, cost measures can produce contradictory results for a specific policy. These problems make it difficult for a policy-maker to determine the best policy. For a cost measures to be of value, one would like to be confident of two things. First one wants to be sure whether the policy is a winner or loser. Second, one wants to be confident that a measure produces the correct policy ranking. That is, one wants to have confidence in a policy measure&apos;s ability to correctly rank policies from most beneficial to most harmful. This paper analyzes empirically these two properties of different costs measures as they pertain to assessing the costs of the carbon abatement policies, especially the Kyoto Protocol, under alternative assumptions about implementation.

  20. ApoE polymorphisms in narcolepsy

    Directory of Open Access Journals (Sweden)

    Kasten Meike

    2001-08-01

    Full Text Available Summary Background Narcolepsy is a common neuropsychiatric disorder characterized by increased daytime sleepiness, cataplexy and hypnagogic hallucinations. Deficiency of the hypocretin neurotransmitter system was shown to be involved in the pathogenesis of narcolepsy in animals and men. There are several hints that neurodegeneration of hypocretin producing neurons in the hypothalamus is the pathological correlate of narcolepsy. The ApoE4 allele is a major contributing factor to early-onset neuronal degeneration in Alzheimer disease and other neurodegenerative diseases as well. Methods To clarify whether the ApoE4 phenotype predisposes to narcolepsy or associates with an earlier disease onset, we have genotyped the ApoE gene in 103 patients with narcolepsy and 101 healthy controls. Results The frequency of the E4 allele of the ApoE gene was 11% in the patient and 15% in the control groups. Furthermore, the mean age of onset did not differ between the ApoE4+ and ApoE4- patient groups. Conclusion Our results exclude the ApoE4 allele as a major risk factor for narcolepsy.

  1. Automated power system for the amplification module of the &apos;'Del'fin'&apos; high power laser. Avtomatizatsiia sistemy energopitaniia usilitel&apos;nogo modulia moshchnoi lazernoi ustanovki &apos;'Del&apos;fin

    Energy Technology Data Exchange (ETDEWEB)

    Allin, A.P.; Doroshkevich, I.L.; Kuchinskii, A.G.; Savchenko, V.M.; Senatskii, U.V.; Sklizkov, G.V.; Subbotin, L.K.; Taranchuk, V.B.

    1981-01-01

    An automated power supply subsystem in the &apos;'Del'fin'&apos; laser apparatus is described that uses a minicomputer on-line with a KAMAK device. Programs are given that are used with the automated power supply for the amplification module of the &apos;'Delfin'&apos; high power laser device for performing the functions of operational monitoring and control and the collection and preliminary processing of information arriving from the capacitor banks and the control components.

  2. The locus for apolipoprotein E (apoE) is close to the Lutheran (Lu) blood group locus on chromosome 19.

    Science.gov (United States)

    Gedde-Dahl, T; Olaisen, B; Teisberg, P; Wilhelmy, M C; Mevåg, B; Helland, R

    1984-01-01

    Linkage has been described between the loci for apolipoprotein E (apoE) and the complement C3 (C3) on chromosome 19. C3 is known to belong to a linkage group with gene order C3-Se-Lu. The present study revealed linkage between Se and apoE with peak lod score +3.3 at recombination fraction 0.08 in males and +1.36 at 0.22 in females, and linkage between apoE and Lu with lod score +4.52 at zero recombination in sexes combined. The C3-apoE linkage gives lod score +4.00 at theta = 0.18 in males, but +0.04 at theta = 0.45 in females. Triple heterozygote families confirm that apoE is on the Se side and on the Lu side of C3. Allelic association between apoE and Lu has not been ruled out. Combining our data with published data on C3-Se and Se-Lu, this segment of chromosome 19 has an average age sex ratio of female/male recombination of 2.3.

  3. Korea&apos;s 1-watt plan &apos;&apos;Standby Korea 2010&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yungrae

    2010-09-15

    Korea announced standby power of all electronics shall be reduced to below 1W by 2010. Ministry of Knowledge Economy (MKE, Korean government) and Korea Energy Management Corporation (KEMCO) established &apos;&apos;Standby Korea 2010&apos;&apos; which is a roadmap to limit standby power below 1W by 2010. Korea implemented mandatory program over a relatively short period of time, incorporating the better elements from the more established national program and adding new initiatives, such as the threat of using mandatory warning label for products that fail to meet standby power targets.

  4. Revisiting T2KK and T2KO physics potential and $\

    CERN Document Server

    Hagiwara, Kaoru; Okamura, Naotoshi; Takaesu, Yoshitaro

    2016-01-01

    We revisit the sensitivity study of the Tokai-to-Kamioka-and-Korea (T2KK) and Tokai-to-Kamioka-and-Oki (T2KO) proposals where a water Cerenkov detector with the 100 kton fiducial volume is placed in Korea ($L = 1000$ km) and Oki island ($L = 653$ km) in Japan, respectively, in addition to the Super-Kamiokande for determination of the neutrino mass hierarchy and leptonic CP phase ($\\delta_{CP}$). We systematically study the running ratio of the $\

  5. Integriteta podatkov skozi validacijo računalniško podprtega laboratorijskega sistema

    OpenAIRE

    Ramić, Jasmin

    2017-01-01

    Diplomska naloga obravnava zagotavljanje regulatorne skladnosti in validacijo računalniško podprtega laboratorijskega sistema v farmacevtski industriji. Opisuje delovanje in pomen regulatornih organov, pojasnjeni so standardi in primeri dobre prakse, ki se morajo upoštevati v procesu validacije. Z aktivnim uvajanjem zakona na področju elektronskih zapisov in elektronskih podpisov so agencije za prehrano in zdravila uspele postaviti jasne zahteve in smernice v farmacevtski industriji in tako p...

  6. Understanding the Role of Teachers&apos; Culture on Student Discipline

    Science.gov (United States)

    Murphy, Hope Helene

    2011-01-01

    The purpose of this study was to advance educators&apos; understanding of the role of teachers&apos; culture on students&apos; discipline. A key issue in education is disproportionate disciplinary representation of Black male students for cultural behaviors. National and Commonwealth of Virginia discipline data indicate that Black male students…

  7. Reduced binding of human antibodies to cells from GGTA1/CMAH KO pigs.

    Science.gov (United States)

    Burlak, C; Paris, L L; Lutz, A J; Sidner, R A; Estrada, J; Li, P; Tector, M; Tector, A J

    2014-08-01

    Xenotransplantation using genetically modified pig organs could solve the donor organ shortage problem. Two inactivated genes that make humans unique from pigs are GGTA1 and CMAH, the products of which produce the carbohydrate epitopes, aGal and Neu5Gc that attract preformed human antibody. When the GGTA1 and CMAH genes were deleted in pigs, human antibody binding was reduced in preliminary analysis. We analyzed the binding of human IgM and IgG from 121 healthy human serum samples for binding to GGTA1 KO and GGTA1/CMAH KO peripheral blood mononuclear cells (PBMCs). We analyzed a sub population for reactivity toward genetically modified pig PBMCs as compared to chimpanzee and human PBMCs. Deletion of the GGTA1 and CMAH genes in pigs improved the crossmatch results beyond those observed with chimpanzees. Sorting the 121 human samples tested against the GGTA1/CMAH KO pig PBMCs did not reveal a distinguishing feature such as blood group, age or gender. Modification of genes to make pig carbohydrates more similar to humans has improved the crossmatch with human serum significantly.

  8. Central dopamine D2 receptors regulate growth-hormone-dependent body growth and pheromone signaling to conspecific males.

    Science.gov (United States)

    Noaín, Daniela; Pérez-Millán, M Inés; Bello, Estefanía P; Luque, Guillermina M; Casas Cordero, Rodrigo; Gelman, Diego M; Peper, Marcela; Tornadu, Isabel García; Low, Malcolm J; Becú-Villalobos, Damasia; Rubinstein, Marcelo

    2013-03-27

    Competition between adult males for limited resources such as food and receptive females is shaped by the male pattern of pituitary growth hormone (GH) secretion that determines body size and the production of urinary pheromones involved in male-to-male aggression. In the brain, dopamine (DA) provides incentive salience to stimuli that predict the availability of food and sexual partners. Although the importance of the GH axis and central DA neurotransmission in social dominance and fitness is clearly appreciated, the two systems have always been studied unconnectedly. Here we conducted a cell-specific genetic dissection study in conditional mutant mice that selectively lack DA D2 receptors (D2R) from pituitary lactotropes (lacDrd2KO) or neurons (neuroDrd2KO). Whereas lacDrd2KO mice developed a normal GH axis, neuroDrd2KO mice displayed fewer somatotropes; reduced hypothalamic Ghrh expression, pituitary GH content, and serum IGF-I levels; and exhibited reduced body size and weight. As a consequence of a GH axis deficit, neuroDrd2KO adult males excreted low levels of major urinary proteins and their urine failed to promote aggression and territorial behavior in control male challengers, in contrast to the urine taken from control adult males. These findings reveal that central D2Rs mediate a neuroendocrine-exocrine cascade that controls the maturation of the GH axis and downstream signals that are critical for fitness, social dominance, and competition between adult males.

  9. Expression pattern of immediate early genes in the cerebellum of D1R KO, D2R KO, and wild type mice under vestibular-controlled activity.

    Science.gov (United States)

    Nakamura, Toru; Sato, Asako; Kitsukawa, Takashi; Sasaoka, Toshikuni; Yamamori, Tetsuo

    2015-01-01

    We previously reported the different motor abilities of D1R knockout (KO), D2R KO and wild-type (WT) mice. To understand the interaction between the cerebellum and the striatal direct and indirect pathways, we examined the expression patterns of immediate early genes (IEG) in the cerebellum of these three genotypes of mice. In the WT naive mice, there was little IEG expression. However, we observed a robust expression of c-fos mRNA in the vermis and hemisphere after running rota-rod tasks. In the vermis, c-fos was expressed throughout the lobules except lobule 7, and also in crus 1 of the ansiform lobule (Crus1), copula of the pyramis (Cop) and most significantly in the flocculus in the hemisphere. jun-B was much less expressed but more preferentially expressed in Purkinje cells. In addition, we observed significant levels of c-fos and jun-B expressions after handling mice, and after the stationary rota-rod task in naive mice. Surprisingly, we observed significant expression of c-fos and jun-B even 30 min after single weighing. Nonetheless, certain additional c-fos and jun-B expressions were observed in three genotypes of the mice that experienced several sessions of motor tasks 24 h after stationary rota-rod task and on days 1 and 5 after rota-rod tasks, but no significant differences in expressions after the running rota-rod tasks were observed among the three genotypes. In addition, there may be some differences 24 h after the stationary rota-rod task between the naive mice and the mice that experienced several sessions of motor tasks.

  10. An integrated evaluation of formation inhomogeneity, accounting for the field &apos;'trend'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Sultanov, C.A.; Akhmodov, A.M.; Allakhverdieva, L.I.

    1979-01-01

    It is recommended that the degree of characteristic variation in the geological parameters by area be accounted for using the &apos;'trend'&apos; characteristic when evaluating the geological inhomogeneity of formations; this characteristic denotes any systematic variations which are noted in the diagram of the target under study. A method for solving these problems is proposed. A problem is solved using a sample study of the ruggedness factor of several beds in the 16th formation and the series of the 15th formation in the Starii field and the Bukhti Ilch field in Bibi-Eibat. The &apos;&apos;regression analysis&apos;&apos; program was used in drafting these models; this program was developed at the computer center of the Academy of Sciences of the Estonian SSR. A multiple correlation coefficient for square-law models was used to evaluate the &apos;'trend'&apos;.

  11. A &apos;'LIGHT'&apos;, CENTRALLY CONCENTRATED MILKY WAY HALO?

    Energy Technology Data Exchange (ETDEWEB)

    Rashkov, Valery; Pillepich, Annalisa; Deason, Alis J.; Madau, Piero [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Rockosi, Constance M. [Department of Astronomy and Astrophysics, UCO/Lock Observatory, University of California, Santa Cruz, CA 95064 (United States); Guedes, Javiera [Institute for Astronomy, ETH Zurich, 8093 Zurich (Switzerland); Mayer, Lucio [Institute of Theoretical Physics, University of Zurich, CH-9057 Zurich (Switzerland)

    2013-08-20

    We discuss a novel approach to &apos;'weighing'&apos; the Milky Way (MW) dark matter halo, one that combines the latest samples of halo stars selected from the Sloan Digital Sky Survey (SDSS) with state of the art numerical simulations of MW analogs. The fully cosmological runs employed in the present study include &apos;'Eris'&apos;, one of the highest resolution hydrodynamical simulations of the formation of a M{sub vir} = 8 Multiplication-Sign 10{sup 11} M{sub Sun} late-type spiral, and the dark-matter-only M{sub vir} = 1.7 Multiplication-Sign 10{sup 12} M{sub Sun} &apos;&apos;Via Lactea II&apos;&apos; (VLII) simulation. Eris provides an excellent laboratory for creating mock SDSS samples of tracer halo stars, and we successfully compare their density, velocity anisotropy, and radial velocity dispersion profiles with the observational data. Most mock SDSS realizations show the same &apos;&apos;cold veil&apos;&apos; recently observed in the distant stellar halo of the MW, with tracers as cold as {sigma}{sub los} Almost-Equal-To 50 km s{sup -1} between 100 and 150 kpc. Controlled experiments based on the integration of the spherical Jeans equation as well as a particle tagging technique applied to VLII show that a &apos;'heavy'&apos; M{sub vir} Almost-Equal-To 2 Multiplication-Sign 10{sup 12} M{sub Sun} realistic host produces a poor fit to the kinematic SDSS data. We argue that these results offer added evidence for a &apos;'light'&apos;, centrally concentrated MW halo.

  12. The expression change of amyloid protein β in the hippocampal neurons of ApoE knockout mice%ApoE基因敲除小鼠海马神经元内β淀粉样蛋白的表达变化

    Institute of Scientific and Technical Information of China (English)

    张宁; 汪渊; 贾雪梅; 倪普; 徐凌凡; 钱雅琴; 汪涛; 刘娟; 周祎; 桂丽; 黄大可

    2011-01-01

    Objective To observe the effect of the knockout of ApoE gene( ApoE KO ) on the expression of amyloid protein β( Aβ ) in the hippocampal neurons of the mice and discover its possible relationship with Alzheimer Disease’s pathologic processes. Methods Ten wild-type and ten ApoE KO mice were fed with common chow as the control group ( group C ) and the KO group respectively, while 10 ApoE KO mice were fed with high fat diet as group KO-HF. Twelve weeks later,the weight and the lid of these mice were measured. The brain tissues were observed by HE and immunohistochemistry staining. Then used the image analyzing system of the computer to detect the expression of Aβ in the hippocampal neurons of the mice. Results In the ApoE KO group , weight,total cholesterol, triglyceride,low-density lipoprotein cholesterol were higher than those in the control group , and these changes were more significant in group KO-HF. The average optical densities of Aβ were ( 0. 239 5 ±0. 085 8 ),( 0. 288 5 ±0. 121 3 ) and ( 0. 350 7±0. 141 5 ) in group C, group KO and group KO-HF respectively, while these data were all significant( P <0. 05 ). Conclusion The knockout of ApoE gene and high fat diet can lead to the deposition of Aβ , which may have close relationship with the occurrence and development of Alzheimer Disease’s pathologicprocesses.%目的 观察载脂蛋白E基因敲除(ApoE KO)对小鼠海马神经元内β淀粉样蛋白(Aβ)表达的影响,探讨其与神经退行性疾病的认知功能障碍之间的可能联系.方法 10只正常C57BL/6J小鼠予普通饲料喂养作为对照(C)组,10只ApoE-KO的C57BL/6J小鼠予普通饲料喂养作为KO组,10只ApoE KO的C57BL/6J小鼠予高脂饲料喂养作为KO-HF组.小鼠成模后称重,取血检测血脂,取小鼠脑组织分别进行HE、免疫组化染色,并应用计算机图像分析系统检测小鼠海马神经元内Aβ的表达变化.结果 与C组比较,KO组和KO-HF组体重、总胆固醇、甘油三酯及低

  13. 7,8-Dihydroxyflavone Ameliorates Cognitive Impairment by Inhibiting Expression of Tau Pathology in ApoE-Knockout Mice

    Directory of Open Access Journals (Sweden)

    Yang Tan

    2016-11-01

    Full Text Available 7,8-Dihydroxyflavone (7,8-DHF, a tyrosine kinase B (TrkB agonist that mimics the neuroprotective properties of brain-derived neurotrophic factor, which can not efficiently deliver into the brain, has been reported to be useful in ameliorating cognitive impairment in many diseases. Researches have indicated that apolipoprotein E-knockout (ApoE-KO mouse was associated with cognitive alteration via various mechanisms. Our present study investigated the possible mechanisms of cognitive impairment of ApoE-KO mouse fed with western type diet and the protective effects of 7,8-DHF in improving spatial learning and memory in ApoE-KO mouse. 5-weeks-old ApoE-KO mice and C57BL/6 mice were chronically treated with 7,8-DHF (with a dosage of 5mg/kg or vehicles orally for 25 weeks, and then subjected to Morris water maze at the age of 30 weeks to evaluate the cognitive performances. Afterwards, histology analysis and western blotting were performed. Spatial learning and memory deficits were observed in ApoE-KO mice, which were consistent with higher expression of active-asparaginyl endopeptidase (active-AEP as well as AEP-derived truncated tauN368 compared with normal group. In addition to that, long-term treatment of 7,8-DHF dramatically ameliorated cognitive decline in ApoE-KO mice, accompanied by the activation in phosphorylated protein kinase B (Akt/glycogen synthase kinase-3β (GSK-3β pathway and down-regulated expression of tau S396 and PHF-tau (phosphorylated tau at ser396 and ser404 epitope. These findings suggested that cognitive impairment of ApoE-KO mouse might associate with tau pathology and 7,8-DHF could activate AKT and then phosphorylate its downstream molecule to inhibit expression of abnormal tau, meanwhile, 7,8-DHF could reduce the expression of active-AEP and then inhibit production of truncated tauN368.

  14. Loss of the nuclear receptor corepressor SLIRP compromises male fertility.

    Directory of Open Access Journals (Sweden)

    Shane M Colley

    Full Text Available Nuclear receptors (NRs and their coregulators play fundamental roles in initiating and directing gene expression influencing mammalian reproduction, development and metabolism. SRA stem Loop Interacting RNA-binding Protein (SLIRP is a Steroid receptor RNA Activator (SRA RNA-binding protein that is a potent repressor of NR activity. SLIRP is present in complexes associated with NR target genes in the nucleus; however, it is also abundant in mitochondria where it affects mitochondrial mRNA transcription and energy turnover. In further characterisation studies, we observed SLIRP protein in the testis where its localization pattern changes from mitochondrial in diploid cells to peri-acrosomal and the tail in mature sperm. To investigate the in vivo effects of SLIRP, we generated a SLIRP knockout (KO mouse. This animal is viable, but sub-fertile. Specifically, when homozygous KO males are crossed with wild type (WT females the resultant average litter size is reduced by approximately one third compared with those produced by WT males and females. Further, SLIRP KO mice produced significantly fewer progressively motile sperm than WT animals. Electron microscopy identified disruption of the mid-piece/annulus junction in homozygous KO sperm and altered mitochondrial morphology. In sum, our data implicates SLIRP in regulating male fertility, wherein its loss results in asthenozoospermia associated with compromised sperm structure and mitochondrial morphology.

  15. Oxidative Stress, Skin Aging and Antioxidant Therapy / Oksidacioni Stres, Starenje Kože I Antioksidaciona Terapija

    Directory of Open Access Journals (Sweden)

    Stojiljković Dragana

    2014-12-01

    Full Text Available Starenje kože je dinamičan proces koji se dešava usled hronološkog starenja i foto-starenja izazvanog izlaganjem delovanju faktora spoljašnje sredine, pre svega UV (eng. ultraviolet zračenja. Kumulativni oksidacioni stres, formiranje slobodnih radikala i njihov nepovoljan uticaj na biološke sisteme u ćelijama kože, predstavljju čest i zajednički mehanizam oba procesa starenja kože. Formirane reaktivne kiseonične vrste (eng. reactive oxygen species-ROS mogu dovesti do oksidacije gradivnih molekula ćelija. Peroksidacija lipida, oštećenje membranskih proteina i DNK mutacije mogu dovesti do pojave strukturnih, funkcionalnih, kao i estetskih promena na koži, a takođe mogu pokrenuti razvoj mnogih bolesti.

  16. Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2.

    Science.gov (United States)

    Vandal, Milène; Alata, Wael; Tremblay, Cyntia; Rioux-Perreault, Christine; Salem, Norman; Calon, Frédéric; Plourde, Mélanie

    2014-05-01

    Benefits on cognition from docosahexaenoic acid (DHA, 22 : 6 n-3) intake are absent in humans carrying apolipoprotein E ε4 allele (APOE4), the most important genetic risk factor for Alzheimer's disease (AD). To test the hypothesis that carrying APOE4 impairs DHA distribution, we evaluated plasma and brain fatty acid profiles and uptake of [(14) C]-DHA using in situ cerebral perfusion through the blood-brain barrier in 4- and 13-month-old male and female APOE-targeted replacement mice (APOE2, APOE3, and APOE4), fed with a DHA-depleted diet. Cortical and plasma DHA were 9% lower and 34% higher in APOE4 compared to APOE2 mice, respectively. Brain uptake of [(14) C]-DHA was 24% lower in APOE4 versus APOE2 mice. A significant relationship was established between DHA and apoE concentrations in the cortex of mice (r(2) = 0.21) and AD patients (r(2) = 0.32). Altogether, our results suggest that lower brain uptake of DHA in APOE4 than in APOE2 mice may limit the accumulation of DHA in cerebral tissues. These data provide a mechanistic explanation for the lack of benefit of DHA in APOE4 carriers on cognitive function and the risk of AD. Using human APOE2, 3, and 4 isoform-specific transgenic mice, we found a lower brain uptake of docosahexaenoic acid (DHA) in APOE4 than in APOE2 mice that may limit the biodistribution of DHA in cerebral tissues. These data provide a mechanistic explanation for the lack of benefit of DHA in APOE4 carriers on cognitive function and the risk of Alzheimer's disease (AD).

  17. Contemporary population and development challenges in the Municipality of Dubrovačko Primorje, Croatia

    Directory of Open Access Journals (Sweden)

    Helena Karlić Mujo

    2010-06-01

    Full Text Available The purpose of this paper is to define the basic issues and opportunities challenging the modern development of the Municipality of Dubrovačko Primorje, their causes and effects. The processes of depopulation affected this poorly developed rural region since 1960s, which had been influenced by various factors: development polarisation caused by intensive development of tourism, the poor traffic infrastructure in the highland-area of the Municipality and the unsolved water supply issue. In 1990s a series of events intensified negative demographic trends as follows: aggression on Croatia, occupation during which residential, economic and infrastructural buildings were destroyed and burnt, as well as an earthquake which happened after the return of the refugees. The long-lasting rural emigration from this region towards Dubrovnik caused not only an instantaneous decrease of population but also a contraction of the renewing basis and an accelerated decrease of natural growth in the Municipality of Dubrovačko Primorje. In that way the emigrational depopulation as a consequence of a specific socioeconomic development, became the cause of the current biological depopulation. The intensity of the depopulation processes has been established by an analysis of a total population dynamics and the changes in biological and economic population structure. The conclusion of the study indicates activities which have promising development in the Municipality of Dubrovačko Primorje and which might partly stop the negative demographic trends. Those are mainly traditional activities in this region which are not commercially used enough. They should prevent any further emigration and perhaps even attract those who immigrated, back to their place of birth.

  18. Exaggerated phosphorylation of brain tau protein in CRH KO mice exposed to repeated immobilization stress.

    Science.gov (United States)

    Kvetnansky, Richard; Novak, Petr; Vargovic, Peter; Lejavova, Katarina; Horvathova, Lubica; Ondicova, Katarina; Manz, George; Filipcik, Peter; Novak, Michal; Mravec, Boris

    2016-07-01

    Neuroendocrine and behavioral stress responses are orchestrated by corticotropin-releasing hormone (CRH) and norepinephrine (NE) synthesizing neurons. Recent findings indicate that stress may promote development of neurofibrillary pathology in Alzheimer's disease. Therefore, we investigated relationships among stress, tau protein phosphorylation, and brain NE using wild-type (WT) and CRH-knockout (CRH KO) mice. We assessed expression of phosphorylated tau (p-tau) at the PHF-1 epitope and NE concentrations in the locus coeruleus (LC), A1/C1 and A2/C2 catecholaminergic cell groups, hippocampus, amygdala, nucleus basalis magnocellularis, and frontal cortex of unstressed, singly stressed or repeatedly stressed mice. Moreover, gene expression and protein levels of tyrosine hydroxylase (TH) and CRH receptor mRNA were determined in the LC. Plasma corticosterone levels were also measured. Exposure to a single stress increases tau phosphorylation throughout the brain in WT mice when compared to singly stressed CRH KO animals. In contrast, repeatedly stressed CRH KO mice showed exaggerated tau phosphorylation relative to WT controls. We also observed differences in extent of tau phosphorylation between investigated structures, e.g. the LC and hippocampus. Moreover, CRH deficiency leads to different responses to stress in gene expression of TH, NE concentrations, CRH receptor mRNA, and plasma corticosterone levels. Our data indicate that CRH effects on tau phosphorylation are dependent on whether stress is single or repeated, and differs between brain regions. Our findings indicate that CRH attenuates mechanisms responsible for development of stress-induced tau neuropathology, particularly in conditions of chronic stress. However, the involvement of central catecholaminergic neurons in these mechanisms remains unclear and is in need of further investigation.

  19. The Idea of an Innovated Concept of the Košice Geothermal Project

    Directory of Open Access Journals (Sweden)

    Bujanská Alena

    2015-11-01

    Full Text Available Slovakia has very limited amounts of fossil resources. However, it has a relatively high potential of geothermal energy which use is far below its possibilities. The most abundant geothermal resource, not only in Slovakia but throughout the central Europe, is Košice basin. Since the publication of the first ideas about the ambitious goal to exploit the geothermal potential of this site, 20 years has passed and three geothermal wells has been made but without any progress. In the article the authors present the idea of a fundamental change in the approach to improve the energy and economic efficiency of the project.

  20. Srečko Kosovel: Selección de poemas

    OpenAIRE

    Santiago Martín

    2006-01-01

    Srečko Kosovel nació el 18 de marzo de 1904 en la pequeña ciudad de Se`ana, en la región del Carso de Eslovenia, cuando ésta aún pertenecía al Imperio austro-húngaro. Después de la Primera Guerra Mundial y con la aparición del poder fascista en Italia, la población eslovena del Carso sufrió fuertes represalias políticas y culturales.

  1. Srečko Kosovel: Selección de poemas

    Directory of Open Access Journals (Sweden)

    Santiago Martín

    2006-12-01

    Full Text Available Srečko Kosovel nació el 18 de marzo de 1904 en la pequeña ciudad de Se`ana, en la región del Carso de Eslovenia, cuando ésta aún pertenecía al Imperio austro-húngaro. Después de la Primera Guerra Mundial y con la aparición del poder fascista en Italia, la población eslovena del Carso sufrió fuertes represalias políticas y culturales.

  2. The &apos;'passivhaus'&apos; standard: from energy efficiency to &apos;green&apos; building; Le standard &apos;'passivhaus'&apos;: de la performance energetique a la construction &apos;'verte'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2005-10-01

    The German voluntary standard &apos;Passivhaus&apos; (passive house) leads to buildings with practically no energy consumption. The first residential buildings of this type were built in 1998 and the first tertiary buildings in 2000. Such a passive house must fulfill 5 efficiency criteria: annual space heating needs {<=} 15 kWh/m{sup 2}, U{sub v} envelope coefficient lower than 0.15 W/(m{sup 2}.K), U{sub v} of openings lower than 0.8 W/(m{sup 2}.K), airtightness {<=} 0.6 volume/hour, and total energy needs (space heating, hot water, ventilation, lighting and domestic uses) measured at the meter lower than 42 kWh/m{sup 2}.year. This article makes a status of the effective efficiency of existing passive buildings both in the residential and tertiary sectors and presents some possible ways of improvement. (J.S.)

  3. Bioethanol production from steam-exploded rice husk by recombinant Escherichia coli KO11.

    Science.gov (United States)

    Tabata, Takamitsu; Yoshiba, Yusuke; Takashina, Tomonori; Hieda, Kazuo; Shimizu, Norio

    2017-03-01

    Rice husk is one of the most abundant types of lignocellulosic biomass. Because of its significant amount of sugars, such as cellulose and hemicellulose, it can be used for the production of biofuels such as bioethanol. However, the complex structure of lignocellulosic biomass, consisting of cellulose, hemicellulose and lignin, is resistant to degradation, which limits biomass utilization for ethanol production. The protection of cellulose by lignin contributes to the recalcitrance of lignocelluloses to hydrolysis. Therefore, we conducted steam-explosion treatment as pretreatment of rice husk. However, recombinant Escherichia coli KO11 did not ferment the reducing sugar solution obtained by enzymatic saccharification of steam-exploded rice husk. When the steam-exploded rice husk was washed with hot water to remove inhibitory substances and M9 medium (without glucose) was used as a fermentation medium, E. coli KO11 completely fermented the reducing sugar solution obtained by enzymatic saccharification of hot water washing-treated steam-exploded rice husk to ethanol. We report here the efficient production of bioethanol using steam-exploded rice husk.

  4. Further Development of Ko Displacement Theory for Deformed Shape Predictions of Nonuniform Aerospace Structures

    Science.gov (United States)

    Ko, William L.; Fleischer, Van Tran

    2009-01-01

    The Ko displacement theory previously formulated for deformed shape predictions of nonuniform beam structures is further developed mathematically. The further-developed displacement equations are expressed explicitly in terms of geometrical parameters of the beam and bending strains at equally spaced strain-sensing stations along the multiplexed fiber-optic sensor line installed on the bottom surface of the beam. The bending strain data can then be input into the displacement equations for calculations of local slopes, deflections, and cross-sectional twist angles for generating the overall deformed shapes of the nonuniform beam. The further-developed displacement theory can also be applied to the deformed shape predictions of nonuniform two-point supported beams, nonuniform panels, nonuniform aircraft wings and fuselages, and so forth. The high degree of accuracy of the further-developed displacement theory for nonuniform beams is validated by finite-element analysis of various nonuniform beam structures. Such structures include tapered tubular beams, depth-tapered unswept and swept wing boxes, width-tapered wing boxes, and double-tapered wing boxes, all under combined bending and torsional loads. The Ko displacement theory, combined with the fiber-optic strain-sensing system, provide a powerful tool for in-flight deformed shape monitoring of unmanned aerospace vehicles by ground-based pilots to maintain safe flights.

  5. &apos;&apos;Social capitalism&apos;&apos; in renewable energy generation: China and California comparisons

    Energy Technology Data Exchange (ETDEWEB)

    Clark, Woodrow W. II.; Li, Xing [Clark Strategic Partners, PO Box 17975, Beverly Hills, CA 90210 (United States)

    2010-03-15

    With a population of over 1.3 billion people, demand for renewable energy is expected to grow to a USD $12 billion market in the near term. Under Renewable Energy Law (REL) in February 2005 in the People&apos;s Republic of China (PRC) passed by the National Congress, renewable energy projects will be able to receive a range of financial incentives starting in 2006, which will more than double the PRC current renewable energy generation from 7% to 15% by 2020. Most of the increase will be in hydroelectric generated power. Nonetheless, the nation and especially the provinces are moving rapidly to develop a wide range of renewable energy generation including solar, wind, geothermal and run of the river. Because China practices &apos;&apos;social capitalism&apos;&apos; as expressed in it&apos;s recurrent Five Year National Plans since 1999, the national government and all the provinces have programs, unlike many western and industrialized nations, to &apos;'plan'&apos; and provide for infrastructures. This paper concerns only the energy infrastructure sector and renewable energy generation in particular. The planning process includes financial incentives and investments which are a major part of the Chinese law focused on &apos;&apos;encouraging foreign investment industries&apos;&apos;. The key part of the law is to guarantee long-term power purchase agreements with state owned and controlled &apos;'utilities'&apos;. In short, China may have gotten the economics of the energy sector correct in its concern for planning and finance. The paper develops these energy infrastructure ideas along with the legal and financial requirements as &apos;'lessons'&apos; learned from the USA and especially California. These lessons now apply to China and allow it to learn from the American mistakes. Empirical data will be drawn from work done in China that examine the renewable energy generation and infrastructures and hence allow the RPC and its

  6. Report of working committee 4 &apos;&apos;transmission of gases&apos;&apos;; Rapport de la commission 4 &apos;&apos;transport des gaz&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Volskij, E.

    2000-07-01

    Report of the WOC 4 Transmission contains the results of works carried out during 1998-2000 by the Committee members and the three study groups. The most important is: - review of actual situation and prospects for the gas pipeline transmission system development; - report of SG-4.1 &apos;Pipeline Ageing and Rehabilitation&apos;, including analysis of pipeline steels, welding and insulation, methods of rehabilitation, the program of pipeline reconstruction; - report of SG-4.2 &apos;Emission monitoring&apos; including appraisal of gas losses and methods of lowering of methane and other emissions of the gas units in different countries; - report of SG-4.3 &apos;Pipelines Integrity Management and Safety&apos; including basic information on gas pipeline failure intensity, key elements of the Integrity Management System of the gas transmission, methods of risk evaluation and the effectiveness of the approach. (authors)

  7. Utilization of demolished composition materials of &apos;'ClimateHouses'&apos;; Verwertung des Abbruchmaterials von &apos;'KlimaHaeusern'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Knappe, Florian; Diebel, Anton; Reinhardt, Joachim; Theis, Stefanie [ifeu-Institut fuer Energie- und Umweltforschung GmbH, Heidelberg (Germany); Leiter, Elisabeth; Rosanelli, Rupert; Vieider, Andreas [Syneco, Bolzano (Italy); Feess, Walter [Firma Feess Erdbau, Kirchheim/Teck (Germany); Bonadio, Martina

    2012-09-15

    In the year 1992, an innovative concept of energy conservation was developed in order to improve the energy standards of new buildings as well as existing buildings. The model &apos;ClimateHouse&apos; has to reduce significantly the energy demand in the area of needs building and living as well as the use of fossil resources and negative impacts on the climate. First of all the authors of the contribution under consideration report on and balance the situation in the province South Tyrol with respect to the design of &apos;ClimateHouses&apos; and the use of construction materials for &apos;ClimateHouses&apos;. This also is valid for solar panels. Within a second step the authors report on how the waste management has to be arranged to other waste mass flows and waste compositions.

  8. &apos;&apos;Substantial Margin of Safety&apos;&apos;: A New Approach to HLW Disposition

    Energy Technology Data Exchange (ETDEWEB)

    Power, M. S.

    2002-02-28

    In the Spring of 2001, the National Research Council published &apos;&apos;Disposition of High-Level Waste and Spent Nuclear Fuel: The Continuing Societal and Technical Challenges.&apos;&apos; (1) While finding the technical case for deep geologic disposal of high-level waste and spent fuel robust, the report focused new attention on societal issues and decision-making. The report appeared against a backdrop of heightened controversy about the development of a geologic repository at Yucca Mountain, Nevada. This paper identifies three principal reasons for the National Research Council committee&apos;s finding that &apos;&apos;Difficulties in achieving public support have been seriously underestimated in the past, and opportunities to gain public trust have been missed.&apos;&apos;

  9. &apos;'Routine'&apos; brain CT in psychiatric patients - does it make sense?; &apos;'Routine'&apos;-Schaedel-CT in der psychiatrischen Diagnostik

    Energy Technology Data Exchange (ETDEWEB)

    Pickuth, D.; Heywang-Koebrunner, S.H.; Spielmann, R.P. [Martin-Luther-Universitaet Halle-Wittenberg, Halle (Germany). Klinik und Poliklinik fuer Diagnostische Radiologie

    1999-11-01

    Purpose: To prospectively assess the spectrum of brain CT findings in psychiatric patients and to determine the number of patients that had an underlying cause for the symptoms. Patients and methods: Over a period of six months, 142 patients (78 males, 64 females; median age 61 [18-91] years) were referred for CT brain scans. Their scans were reviewed, along with the clinical information that was provided in the request form. All the hard copies were reviewed to assess areas of ischaemia, infarction, atrophy, tumours, and haematomas. The majority of requests were to exclude vascular event or space-occupying lesions. Clinical indications included mood disorders (depression, mania), schizophrenic disorders, dementia, personality and behavioural disorders. Results: 31 (22%) were normal. 111 (78%) had varying degrees of ischaemia, infarction and cerebral/cerebellar atrophy. 7 (4.9%) had space-occupying lesions which included two gliomas and five meningiomas. There were two chronic subdural haematomas and one arteriovenous malformation. Conclusion: 1. In our series, pathologic findings in &apos;routine&apos; brain CT&apos;s were encountered in 78%. 2. The incidence of brain tumours was 4.9%, compared with 0.00005% of the general population. 3. CT scanning in psychiatric patients is cost-effective and especially indicated when there is an atypical presentation, or inadequate response to standard treatment. (orig.) [German] Hintergrund: Bei psychiatrischen Patienten wird vielerorts routinemaessig eine kraniale Computertomographie (CCT) durchgefuehrt. Ob der Nutzen die Kosten rechtfertigt, wurde im Rahmen einer Prospektivstudie untersucht. Patienten und Methode: In einem Zeitraum von 6 Monaten wurde bei 142 psychiatrischen Patienten (78 Maenner, 64 Frauen, 18-91 Jahre, Median 61 Jahre) ein CCT angefertigt. Die Untersuchung erfolgt nativ in 5-mm-Schichtdicke, bei klinischem Verdacht auf eine intrakraniale Raumforderung auch kontrastverstaerkt. Ueberweisungsdiagnosen waren v

  10. &apos;Femoral head necrosis&apos; in metabolic and hormonal osteopathies

    Energy Technology Data Exchange (ETDEWEB)

    Heuck, F.H.W.; Treugut, H.

    1984-07-01

    The pathogenesis of bone necrosis is discussed with special attention and with respect to metabolic, hormonal, and vascular factors. The influence of statics and dynamics of the hip joint bones for the development of aseptic necrosis are discussed. 45 patients with &apos;&apos;idiopathic femoral head necroses&apos;&apos; were observed, including 6 cases of renal osteopathy following renal transplantation and immune suppression therapy, 14 cases of long term corticoid therapy, and 11 cases of liver diseases of different genesis. The femoral head necrosis understood as complication of an osteopathy. In our patients there were 31 males and 14 females - which means higher involvement of males. Plain radiological findings and CT-findings of changes of the femoral heat structure in different stages of the disease are described. Early diagnosis of metabolic and hormonal osteopathies is demanded for a joint keeping therapy of the beginning femoral head necrosis. 90 refs.

  11. Chronic exposure to chlorpyrifos triggered body weight increase and memory impairment depending on human apoE polymorphisms in a targeted replacement mouse model.

    Science.gov (United States)

    Peris-Sampedro, Fiona; Basaure, Pia; Reverte, Ingrid; Cabré, Maria; Domingo, José L; Colomina, Maria Teresa

    2015-05-15

    Despite restrictions on their use, humans are still constantly exposed to organophosphates (OPs). A huge number of studies have ratified the neurotoxic effects of chlorpyrifos (CPF) and suggested its association with neurodegenerative diseases, but data are still scarce. Human apolipoprotein E (apoE) plays an important role in lipid transport and distribution. In humans, the apoE4 isoform has been linked to an increased risk of Alzheimer's disease (AD). ApoE3 is the most prevalent isoform worldwide, and has been often established as the healthful one. The current study, performed in targeted replacement (TR) adult male mice, aimed to inquire whether genetic variations of the human apoE respond differently to a chronic dietary challenge with CPF. At four/five months of age, mice carrying apoE2, apoE3 or apoE4 were pair-fed a diet supplemented with CPF at 0 or 2mg/kg body weight/day for 13weeks. Cholinergic signs were monitored daily and body weight changes weekly. In the last week of treatment, learning and memory were assessed in a Barnes maze task. Dietary CPF challenge increased body weight only in apoE3 mice. Differences in the acquisition and retention of the Barnes maze were attributed to apoE genetic differences. Our results showed that apoE4 mice performed worse than apoE2 and apoE3 carriers in the acquisition period of the spatial task, and that apoE2 mice had poorer retention than the other two genotypes. On the other hand, CPF increased the search velocity of apoE2 subjects during the acquisition period. Retention was impaired only in CPF-exposed apoE3 mice. These results underline that gene×environment interactions need to be taken into account in epidemiological studies. Given that apoE3, the most common polymorphism in humans, has proved to be the most sensitive to CPF, the potential implications for human health merit serious thought.

  12. &apos;et&apos; special: &apos;&apos;E-world of energy&apos;&apos;; &apos;et&apos;-special: &apos;&apos;E-world of energy&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2001-02-01

    The &apos;et&apos; special on the conference &apos;E-world of energy&apos;, held from February 13 - 15, 2001 in Essen (Germany) presents contributions of experts who offer solutions to issues and many topical questions arising in the business of traders and utilities as participants of (international) energy markets at various stages of transition towards workable competition. The translated titles of the 15 contributions reproduced in this &apos;et&apos; special indicate the major contents of the conference papers: 1. Internet-based wholesale power trading as a competitive option to the power exchange. 2. Forward graphs in European electricity markets. 3. Portfolio management in energy trading. 4. Risk management concepts in energy trading. 5. E-commerce as a driving force of a change in the energy markets. 6. eHuman resources management - a vital aspect of corporate success. 7. A brand policy for electricity? 8. Is it really only the price that counts for the customers? 9. The City Power network: an example of successful customer loyalty strategy for local and regional utilities. 10. The Call Center, an important instrument for customer loyalty programmes. 11. eCommerce or eLlusion? 12. eBusiness as a corporate strategy. 13. Meeting the challenges of increasing IT requirements. 14. IT solutions for transmission and distribution network management. 15. Target costing - pinpointed cost planning and control for the energy supply industry. (orig./CB) [German] In dem &apos;et&apos;-Special zur Konferenz &apos;E-world of energy&apos;, die vom 13.- 15. Februar 2001 in Essen stattfand, bieten Experten Loesungsvorschlaege fuer die aktuellen Fragen und Probleme an, die sich auf dem Weg zu liberalisierten Energiemaerkten stellen. Die folgenden Titel der 15 Beitraege geben eine Uebersicht ueber den Inhalt der Konferenzbeitraege. Themen: 1. Internetbasierte Grosshandelsmaerkte als Konkurrenz zu Energieboersen 2. Forward-Kurven in europaeischen Strommaerkten 3

  13. Habitat Characteristics of Bracken-Covered Areas Intended for Afforestation in Ličko Sredogorje

    Directory of Open Access Journals (Sweden)

    Zvonko Seletković

    2013-12-01

    Full Text Available Background and Purpose: Forest cultures in continental part of Croatia are mainly based on bracken-covered areas and moors on deserted agriculture soils and pastures. Successful afforestation i.e. establishment of forest cultures depends among other things on the understanding of habitats and ecology of forest trees. The choice of best species of forest trees for afforestation needs to be based on the research in soil and climate characteristics of target habitats. The aims of this research were to show mesoclimatic characteristics of Ličko sredogorje and microclimatic and pedological characteristics of Ličko polje. Also, based on habitat characteristics and ecology of forest trees, the aim was to determine species of forest trees suitable for afforestation of bracken-covered areas. Materials and Methods: Climate, microclimate, pedological and plant nutrition researches were done at the area of Lika highlands. Climate analysis was done according to air temperatures, amount of precipitation, relative air humidity and other climate elements and appearances. Composite soil samples were taken from the depth of 0-30 cm in order to determine plant nutrition potential. Samples were prepared for further analysis in the laboratory. Results: The highest average annual air temperature of 9.6 °C was found at weather station Gračac and the lowest at Korenica station (8.1 °C. Average amount of precipitation for this region was around 1500 mm. Monthly rain factors were ranging from arid to perhumid. Considering thermal character of the climate, the area has moderately warm climate. Average volumetric soil humidity is 14.2 %. Soil has strong acid reaction, is very humus, good to richly supplied with total nitrogen, content of physiologically active phosphorus and potassium is low, and C/N ration normal. Conclusions: According to habitat characteristics in the area of Ličko sredogorje and ecological demands of forest tree species, forest cultures of Common

  14. Beta-Catenin Haplo Insufficient Male Mice Do Not Lose Bone in Response to Hindlimb Unloading.

    Directory of Open Access Journals (Sweden)

    Delphine B Maurel

    Full Text Available As the β-catenin pathway has been shown to be involved in mechanotransduction, we sought to determine if haploinsufficiency would affect skeletal response to unloading. It has previously been shown that deletion of both alleles of β-catenin in bone cells results in a fragile skeleton highly susceptible to fracture, but deletion of one allele using Dmp1-Cre (Ctnnb1+/loxP; Dmp1-Cre, cKO HET has little effect on the 2 mo old skeleton. We found that under normal housing conditions, trabecular bone volume was significantly less in 5 mo old male cKO HET mice compared to controls (Ctrl/HET:Tb. BV/TV = 13.96±2.71/8.92±0.95%, Tb.N. = 4.88±0.51/3.95±0.44/mm, Tb. Sp. = 0.20±0.02/0.26±0.03mm, a 36%, 19% and 30% change respectively but not in females suggesting an age and gender related effect. Before performing suspension experiments and to control for the environmental effects, animals with the same tail attachment and housing conditions, but not suspended (NS, were compared to normally housed (NH animals. Attachment and housing resulted in weight loss in both genders and phenotypes. Cortical bone loss was observed in the cKO HET males (NH/NS, Ct BV/TV: 90.45±0.72/89.12±0.56% and both diaphyseal (0.19±0.01/0.17±0.01mm and metaphyseal (0.10±0.01/0.08±0.01mm thickness, but not in female cKO HET mice suggesting that male cKO HET mice are susceptible to attachment and housing conditions. These results with transgenic mice emphasizes the importance of proper controls when attributing skeletal responses to unloading. With suspension, cKO HET male mice did not lose bone unlike female cKO HET mice that had greater trabecular bone loss than controls (Ctrl 9%:cKO HET 21% decrease Tb. N; Ctrl 12%:cKO HET 27% increase Tb. Sp.. Suspended and non-suspended mice lost weight compared to normally housed animals. Taken together, the data suggest a protective effect of β-catenin against the effects of stress in males and partial protection against unloading in

  15. Crystal balls, virtual realities and &apos;storylines&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Courtney, R.S.

    2001-07-01

    &apos;'Projections'&apos; of anthropogenic climate change reported in the Third Assessment Report (TAR) of the UN Intergovernmental Panel on Climate Change (IPCC) are assessed to be based on pseudo-science. (author)

  16. Posterior &apos;'Nutcracker'&apos; phenomenon in a patient with abdominal aortic aneurysm

    Energy Technology Data Exchange (ETDEWEB)

    Puig, Stefan [Department of Radiology, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna (Austria); Department of Emergency Medicine, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna (Austria); Stuehlinger, Hermann Georg; Domanovits, Hans [Department of Emergency Medicine, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna (Austria); Staudenherz, Anton [Department of Emergency Medicine, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna (Austria); Department of Nuclear Medicine, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna (Austria); Zebenholzer, Karin [Department of Emergency Medicine, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna (Austria); Department of Neurology, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna (Austria); Rebhandl, Winfried [Department of Surgery, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna (Austria); Prokop, Mathias [Department of Radiology, University of Vienna, Waehringer Guertel 18-20, 1090 Vienna (Austria)

    2002-07-01

    We report on a posterior &apos;'nutcracker'&apos; phenomenon due to an abdominal aortic aneurysm in a patient with a retro-aortic left renal vein. A 71-year-old man with a known abdominal aortic aneurysm presented in the emergency room with mild hematuria and flank pain. Computed tomography angiography revealed an aortic aneurysm, which compressed the left renal vein between the aorta and the vertebral column. Compression of the left renal vein, due to the aorta with consecutive congestion and hematuria as well as flank pain, was previously described as nutcracker phenomenon. In case of a retro-aortic left renal vein, increase of the aortic diameter can lead to compression of the renal vein and furthermore to the classical signs and symptoms of the &apos;'nutcracker'&apos; phenomenon, even though the aneurysm is not ruptured or there are no aorto-caval or aorto-left renal vein fistulas. (orig.)

  17. Srečko Kosovel and Rabindranath Tagore: Points of Departure and Identification

    Directory of Open Access Journals (Sweden)

    Ana Jelnikar

    2010-12-01

    Full Text Available In this paper I explore some of the connections the Slovene poet Srečko Kosovel (1904–1926 surmised between himself and the Indian poet Rabindranath Tagore (1861–1941. I argue that what linked the two poets into a joint framework across the vastly different cultural and politico-geographic space was not just the fact that Kosovel read Tagore and took inspiration from the Bengali poet at the height of Tagore’s reputation in continental Europe, but that they shared a number of preoccupations, informed by their respective historical positioning. Both wrote from a profound awareness of their region’s subjugated status and endorsed an anti-imperialist stance that rejected nationalism as a viable means of liberation, embracing instead a creative universalist ideal.

  18. Franck-Condon factors for photodetachment from LiO(-), NaO(-), and KO(-)

    Science.gov (United States)

    Bauschlicher, Charles W., Jr.; Partridge, Harry; Pettersson, Lars G. M.

    1993-01-01

    The 1Sigma(+), 3Sigma(+), 1Pi, and 3Pi states of the negative ions and the 2Pi and 2Sigma(+) states of the neutral alkali oxides are studied at high levels of theory. The calculations show that ground state of the negative ions changes from 3Pi for LiO(-) to 1Sigma(+) for KO(-). Although the calculations give a 3Pi ground state for NaO(-), we cannot rule out the possibility that the very low-lying 1Sigma(+) state is the true ground state. The Franck-Condon factors for photodetachment of an electron from the 1Sigma(+) and/or 3Pi states of the negative ion are presented to help interpret photodetachment experiments. Our best results for the A 2Sigma(+) - X 2Pi separations in LiO and NaO are 2496 and 2061/cm, which are in excellent agreement with that deduced (2516 and 2018/cm) from experiment.

  19. Fossil sources: &apos;&apos;Running out&apos;&apos; is not the problem

    Energy Technology Data Exchange (ETDEWEB)

    Scott, D.S. [Victoria Univ., BC (Canada). Inst. for Integrated Energy System

    2005-01-01

    In which we discuss reserves, resources and the mythology that, sooner or later, our fossil sources will be gone. Then, to help appreciate the real reason fossil reserves will ultimately vanish, we evoke Weary Willie&apos;s clown routine &apos;sweeping up the spotlight.&apos; (Author)

  20. Principles and some applications of &apos;&apos;zero field nuclear magnetic resonance&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Llor, A.; Virlet, J.

    1987-10-01

    The method known as &apos;&apos;zero field NMR&apos;&apos; is reviewed. The technique allows the observation of nuclear dipolar and quadrupolar interactions in powder samples, which may otherwise be possible in high field on monocristals only. The anisotropy due to the magnetic field is removed although sensitivity is preserved. This method is compared to other Nuclear Resonance spectroscopies: its originality lies in the measurement of the coherent evolution of the system in zero field after a perturbation induced by suddenly switching the magnetic field. The Fourier transform of the &apos;&apos;zero field free induction decay&apos;&apos; then gives the &apos;&apos;zero field spectrum&apos;&apos;. The ideal experiment is described with its adaptations due to experimental constraints, as realized in our laboratory at Saclay and in the laboratory of A. Pines at Berkeley. We present with our first measurements a review of most of the results published to date on spin 1/2 as well as spin 1/2 (quadrupolar) nuclei. Possible future developments of the method are also discussed.

  1. Cloning and Expression of Apolipoprotein E3 and Its Variant apoE2 and apoE4

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    In order to obtain three isoforms of apolipoprotein E (apoE), the cDNA encoding apoE3 was obtained by RT-PCR from normal human liver tissue. Site-directed mutagenesis was used to obtain the cDNAs encoding apoE2 and apoE4 isoforms. The 3 cDNAs were subcloned into vector pGEM-3Z and verified by DNA sequencing. The expression recombinant which can express the target protein as a (His) 6-tagged fusion was constructed by subcloning apoE cDNA into vector pT7-PL. The purified proteins were gained by Ni-NTA column. The SDS-PAGE results revealed the 6 His fusion proteins (apoE2, apoE3 and apoE4) were correctly expressed and purified successfully.

  2. VODNI POTENCIAL ČRNE GORE IN MOŽNOSTI IZGRADNJE MHE NA POTOKU OĐZAČKO VRELO

    OpenAIRE

    Softić, Edis

    2012-01-01

    V diplomski nalogi je predstavljen hidrometeorološki potencial Črne gore, izkoriščanje vodnih virov črnogorskih rek za proizvodnjo električne energije. Podrobneje je obravnavan severni del Črne gore, majhni vodotoki na področju občine Pljevlja. Poseben poudarek je na potoku Ođzačko vrelo. Na podlagi meritev pretoka na vodotoku Ođzačko vrelo je načrtovana mala hidroelektrarna. Poleg samega načrtovanja majhne hidroelektrarne so opisani tudi pogoji za izgradnjo tovrstnih hidroelektrarn v Črni go...

  3. The Growth Hormone Receptor Gene-Disrupted (GHR-KO) Mouse Fails to Respond to an Intermittent Fasting (IF) Diet

    OpenAIRE

    Arum, Oge; Bonkowski, Michael S.; Rocha, Juliana S.; Bartke, Andrzej

    2009-01-01

    The interaction of longevity-conferring genes with longevity-conferring diets is poorly understood. The growth hormone receptor gene-disrupted (GHR-KO) mouse is long-lived; and this longevity is not responsive to 30% caloric restriction (CR), in contrast to wild-type animals from the same strain. To determine whether this may have been limited to a particular level of dietary restriction (DR), we subjected GHR-KO mice to a different dietary restriction regimen, an intermittent fasting (IF) diet.

  4. 2001 &apos;&apos;You Have the Power&apos;&apos; campaign [Federal Energy Management Program]. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-01-01

    The Tasks of 2001 &apos;&apos;You Have the Power&apos;&apos; campaign by the Federal Energy Management Program (FEMP) are: Task 1--Interagency Planning Meetings; Task 2--Ear Day Event; Task 3--Earth Day and Energy Awareness Month Activities; Task 4--Regional Target; Task 5--Outreach Tools and Campaign Products; Task 6--Private Sector Participation; Task 7--&apos;&apos;You Have the Power&apos;&apos; on the FEMP Web Site; and Task 8--Effective Communications.

  5. &apos;&apos;Activity based costing&apos;&apos; in radiology; &apos;&apos;Activity based costing&apos;&apos; in der Radiologie

    Energy Technology Data Exchange (ETDEWEB)

    Klose, K.J. [Klinik fuer Strahlendiagnostik, Medizinisches Zentrum fuer Radiologie, Philipps-Universitaet, Marburg (Germany); Boettcher, J. [pphc GmbH, Ammersbeck (Germany)

    2002-05-01

    Background: The introduction of diagnosis related groups for reimbursement of hospital services in Germany (g-drg) demands for a reconsideration of utilization of radiological products and costs related to them. Methods: Traditional cost accounting as approach to internal, department related budgets are compared with the accounting method of activity based costing (ABC). The steps, which are necessary to implement ABC in radiology are developed.Conclusions: The introduction of a process-oriented cost analysis is feasible for radiology departments. ABC plays a central role in the set-up of decentralized controlling functions within this institutions. The implementation seems to be a strategic challenge for department managers to get more appropriate data for adequate enterprise decisions. The necessary steps of process analysis can be used for other purposes (Certification, digital migration) as well. (orig.) [German] Hintergrund. Die Oekonomisierung der Medizin in Deutschland, die in der beabsichtigten Einfuehrung der kostenhomogenen Verguetungsklassen nach den &apos;&apos;diagnosis related groups - DRG&apos;s'&apos; ihren vorlaeufigen Hoehepunkt finden soll, erfordert eine Neuorientierung im Einsatz und in der Beurteilung der Wirtschaftlichkeit radiologischer Verfahren.Methode. Traditionelle Kostenrechnungen bzw. Verfahren zur internen Budgetierung werden der Prozesskostenbetrachtung (&apos;&apos;activity based costing&apos;&apos; - ABC) gegenuebergestellt, deren auf radiologische Belange zugeschnittene Methodik Schritt fuer Schritt entwickelt wird.Ergebnisse. Die Betrachtung radiologischer Arbeitsprozesse auf der Basis des ABC gestattet anhand der bisher publizierten Ergebnisse eine bessere Einschaetzung von Steuerungsimpulsen, die zu einer Effizienzsteigerung in radiologischen Prozessen fuehren koennen.Schlussfolgerungen. Die Einfuehrung einer prozessorientierten Kostenanalyse ist fuer vielfaeltige Belange einer Radiologieabteilung moeglich. Sie stellt

  6. Dietary cladode powder from wild type and domesticated Opuntia species reduces atherogenesis in apoE knock-out mice.

    Science.gov (United States)

    Garoby-Salom, Sandra; Guéraud, Françoise; Camaré, Caroline; de la Rosa, Ana-Paulina Barba; Rossignol, Michel; Santos Díaz, María del Socorro; Salvayre, Robert; Negre-Salvayre, Anne

    2016-03-01

    Dietary intake of Opuntia species may prevent the development of cardiovascular diseases. The present study was designed to characterize the biological antioxidant and anti-inflammatory properties of Opuntia species and to investigate whether Opuntia cladodes prevent the development of atherosclerosis in vivo, in apoE(-)KO mice. The effects of the two Opuntia species, the wild Opuntia streptacantha and the domesticated Opuntia ficus-indica, were tested on the generation of intra- and extracellular reactive oxygen species (ROS) production and kinetics of the LDL oxidation by murine CRL2181 endothelial cells and on the subsequent inflammatory signaling leading to the adhesion of monocytes on the activated endothelium and the formation of foam cells. Opuntia species blocked the extracellular ROS (superoxide anion) generation and LDL oxidation by CRL2181, as well as the intracellular ROS rise and signaling evoked by the oxidized LDL, including the nuclear translocation of the transcription factor NFκB, the expression of ICAM-1 and VCAM-1 adhesion molecules, and the adhesion of monocytes to CRL2181. In vivo, Opuntia significantly reduced the formation of atherosclerotic lesions and the accumulation of 4-hydroxynonenal adducts in the vascular wall of apoE-KO mice, indicating that Opuntia cladodes prevent lipid oxidation in the vascular wall. In conclusion, wild and domesticated Opuntia species exhibit antioxidant, anti-inflammatory, and antiatherogenic properties which emphasize their nutritional benefit for preventing cardiovascular diseases.

  7. ApoE (Apolipoprotein E) Genotyping

    Science.gov (United States)

    ... Home Visit Global Sites Search Help? APOE Genotyping, Alzheimer Disease Share this page: Was this page helpful? Formal ... help in the diagnosis of probable late onset Alzheimer disease (AD) in symptomatic adults. It is called susceptibility ...

  8. European day &apos;&apos;in town, without my car&apos;&apos;; Journee europeen &apos;&apos;en ville, sans ma voiture&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-10-01

    70 million inhabitants took part in the day &apos;&apos;In town, without my car&apos;&apos; on 22 September of this year. It is a great success for this European first. The objective of Energie-Cites association being to promote sustainable local energy policies, that is to say policies aimed at improving energy efficiency, increasing the use of renewable energy sources and limiting nuisance and pollution linked to energy consumption, the association is pleased that this event helped focus public attention on transport. It is indeed in this sector that uncontrolled upswings in energy consumption and greenhouse gas emissions are the most important. This report presents the evaluation of this European initiative and details the actions in some towns. (A.L.B.)

  9. The effect of methanol extracts of tsao-ko (Amomum tsao-ko Crevost et Lemaire) on digestive enzyme and antioxidant activity in vitro, and plasma lipids and glucose and liver lipids in mice.

    Science.gov (United States)

    Yu, Longquan; Shirai, Nobuya; Suzuki, Hiramitsu; Sugane, Nozomi; Hosono, Tsuyoshi; Nakajima, Yoshijiro; Kajiwara, Masahiro; Takatori, Kazuhiro

    2010-01-01

    Our previous study showed that tsao-ko intake can lower plasma and liver triacylglycerol (TG) concentrations and has hypoglycemic and antioxidant activity in mice. This study involved separating two major fractions (A and B) from the methanol extracts (MeX) of tsao-ko using silica gel column chromatography, and then determining the effect of the fractions in vivo and in vitro to clarify the most effective components of tsao-ko. An intake of MeX and A fraction statistically significantly reduced body lipids and plasma thiobarbitutic acid reactive substances (TBARS) concentrations compared with the control and inhibited lipase and alpha-glucosidase activities. These reductions were not observed in mice fed the B fraction and these inhibitions of B fraction were mild compared with MeX and A fraction. The plasma and liver TG concentrations of each fraction group did not show significant differences compared with the control. The [M-H](+) and maximum UV absorption of the A fraction were 291 m/z and 279 nm, respectively. The peak of A fraction appeared at a similar time to the epicatechin standard in the LC/MS/MS analysis and the MS/MS spectrum of the A fraction was similar to that of the epicatechin standard. It was concluded that the most effective component of tsao-ko for body lipid reduction and hypoglycemic and antioxidant activity was contained in the polar fraction and the evidence suggested that this component could be epicatechin. However, the strongest TG lowering components of tsao-ko may be methanol insoluble.

  10. The German &apos;'Energiewende'&apos;. Evaluation after the Paris-agreement; Die Deutsche Energiewende. Bewertung nach dem Klima-Abkommen von Paris

    Energy Technology Data Exchange (ETDEWEB)

    Roth, Eike

    2016-08-01

    The World-Climate-Summit 2016 in Paris agreed to exacerbated goals for climate protection. This paper will scrutinize whether Germany can comply with its Paris-obligations by continuing the ongoing German &apos;'Energiewende'&apos;. The result is clear-cut: The German &apos;'Energiewende'&apos; is inadequate. Due to the cap-and-trade system of the EU the &apos;''Energiewende'&apos;.

  11. Methods for In-Flight Wing Shape Predictions of Highly Flexible Unmanned Aerial Vehicles: Formulation of Ko Displacement Theory

    Science.gov (United States)

    Ko, William L.; Fleischer, Van Tran

    2010-01-01

    The Ko displacement theory is formulated for a cantilever tubular wing spar under bending, torsion, and combined bending and torsion loading. The Ko displacement equations are expressed in terms of strains measured at multiple sensing stations equally spaced on the surface of the wing spar. The bending and distortion strain data can then be input to the displacement equations to calculate slopes, deflections, and cross-sectional twist angles of the wing spar at the strain-sensing stations for generating the deformed shapes of flexible aircraft wing spars. The displacement equations have been successfully validated for accuracy by finite-element analysis. The Ko displacement theory that has been formulated could also be applied to calculate the deformed shape of simple and tapered beams, plates, and tapered cantilever wing boxes. The Ko displacement theory and associated strain-sensing system (such as fiber optic sensors) form a powerful tool for in-flight deformation monitoring of flexible wings and tails, such as those often employed on unmanned aerial vehicles. Ultimately, the calculated displacement data can be visually displayed in real time to the ground-based pilot for monitoring the deformed shape of unmanned aerial vehicles during flight.

  12. Near-Complete Genome Sequence of Thalassospira sp. Strain KO164 Isolated from a Lignin-Enriched Marine Sediment Microcosm.

    Science.gov (United States)

    Woo, Hannah L; O'Dell, Kaela B; Utturkar, Sagar; McBride, Kathryn R; Huntemann, Marcel; Clum, Alicia; Pillay, Manoj; Palaniappan, Krishnaveni; Varghese, Neha; Mikhailova, Natalia; Stamatis, Dimitrios; Reddy, T B K; Ngan, Chew Yee; Daum, Chris; Shapiro, Nicole; Markowitz, Victor; Ivanova, Natalia; Kyrpides, Nikos; Woyke, Tanja; Brown, Steven D; Hazen, Terry C

    2016-11-23

    Thalassospira sp. strain KO164 was isolated from eastern Mediterranean seawater and sediment laboratory microcosms enriched on insoluble organosolv lignin under oxic conditions. The near-complete genome sequence presented here will facilitate analyses into this deep-ocean bacterium's ability to degrade recalcitrant organics such as lignin.

  13. Acquisition of the Korean Imperfective Aspect Markers "-ko iss-" and "-a iss-" by Japanese Learners: A Multiple-Factor Account

    Science.gov (United States)

    Ryu, Ju-Yeon; Horie, Kaoru; Shirai, Yasuhiro

    2015-01-01

    Although cross-linguistic research on second language tense-aspect acquisition has uncovered universal tendencies concerning the association between verbal semantics and tense-aspect markers, it is still unclear what mechanisms underlie this link. This study investigates the acquisition of two imperfective aspect markers ("-ko iss-" and…

  14. Male Infertility

    Science.gov (United States)

    ... the urethra. Chromosome defects. Inherited disorders such as Klinefelter's syndrome — in which a male is born with ... or major abdominal or pelvic surgery Having a history of undescended testicles Being born with a fertility ...

  15. Investigation of vertebral &apos;&apos;end plate sclerosis&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S.W. [Dept. of Rehabilitation Sciences, Hong Kong Polytechnic Univ., Hung Hom (Hong Kong); Mathie, A.G.; Jackson, J.E. [Diagnostic Radiology, Royal Postgraduate Medical School, Hammersmith Hospital, London (United Kingdom); Hughes, S.P.F. [Div. of Surgery, Anaesthetics and Intensive Care, London (United Kingdom)

    2001-08-01

    To evaluate the association between vertebral &apos;&apos;end plate sclerosis&apos;&apos; and neck pain. A retrospective study was carried out of lateral cervical spine radiographs with a Picture Archive and Communication System (PACS). Two hundred patients&apos; files were randomly assessed, comprising four equal groups, A to D. The mean ages of the patients were 62{+-}7.4 years, 61{+-}7.5 years, 40{+-}5.6 years and 23{+-}5.6 years respectively. In group A, all patients had symptoms of neck pain and a radiographic diagnosis of &apos;&apos;end plate sclerosis&apos;&apos; of the cervical spine. In groups B to D, asymptomatic patients were recruited and their age groups were 50-69, 30-49 and 10-29 years respectively. Using the PACS, the radiographic density and the sagittal diameter, thickness and area of the end plates at the C5 level were measured. Results and conclusions: No significant differences were found in the radiographic density of the end plates either between the symptomatic and asymptomatic groups (groups A and B), or between different age groups (groups B, C and D). A significant increase in end plate area and thickness was found, however, in both group B (P<0.005) and group C (P<0.01) in comparison with group D. This indicates that the extent of end plate sclerosis increases with age. Our results suggest that the radiographic density of cervical vertebral end plates correlates neither with neck pain nor with increasing age. The radiological sign of &apos;&apos;end plate sclerosis&apos;&apos; may be over-reported, further limiting its value in the assessment of patients with cervical spondylosis. (orig.)

  16. Male sexuality.

    Science.gov (United States)

    Ginsberg, Terrie B

    2010-05-01

    It should be recognized that sexuality in the aging male is of such import that a complete sexual history must be performed. By taking a complete sexual history, facts can be obtained that will allow for appropriate focus relating to a holistic evaluation and will enable us to dispel antiquated sexual myths pertaining to the aging male. If initiated by the history taker, questions concerning sexuality may be discussed more comfortably by the patient. Erectile dysfunction, male sexual response cycle, testosterone, sexually transmitted diseases, human immunodeficiency virus, long-term illness, along with religion and culture are explored in this article with the aim of improving one's knowledge base, self reflection, and awareness of the importance of male sexuality. A complete understanding and appreciation of the aging male's medical history, surgical history, social history, and emotional history as well as his sexual, cultural, and religious concepts will allow the health care provider to better analyze information, and to recommend and provide appropriate advice and treatment to the aging male patient.

  17. Sterile Inflammation Enhances ECM Degradation in Integrin β1 KO Embryonic Skin

    Directory of Open Access Journals (Sweden)

    Ambika S. Kurbet

    2016-09-01

    Full Text Available Epidermal knockout of integrin β1 results in complete disorganization of the basement membrane (BM, resulting in neonatal lethality. Here, we report that this disorganization is exacerbated by an early embryonic inflammatory response involving the recruitment of tissue-resident and monocyte-derived macrophages to the dermal-epidermal junction, associated with increased matrix metalloproteinase activity. Remarkably, the skin barrier in the integrin β1 knockout animals is intact, suggesting that this inflammatory response is initiated in a sterile environment. We demonstrate that the molecular mechanism involves de novo expression of integrin αvβ6 in the basal epidermal cells, which activates a TGF-β1 driven inflammatory cascade resulting in upregulation of dermal NF-κB in a Tenascin C-dependent manner. Importantly, treatment of β1 KO embryos in utero with small molecule inhibitors of TGF-βR1 and NF-κB results in marked rescue of the BM defects and amelioration of immune response, revealing an unconventional immuno-protective role for integrin β1 during BM remodeling.

  18. Current Status and Performance Tests of Korea Heat Load Test Facility KoHLT-EB

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sukkwon; Jin, Hyunggon; Shin, Kyuin; Choi, Boguen; Lee, Eohwak; Yoon, Jaesung; Lee, Dongwon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kim, Duckhoi; Cho, Seungyon [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2013-05-15

    A commissioning test has been scheduled to establish the installation and preliminary performance experiments of the copper hypervapotron mockups. And a qualification test will be performed to evaluate the CuCrZr duct liner in the ITER neutral beam injection facility and the ITER first wall small-scale mockups of the semi-prototype, at up to 1.5 and 5 MW/m{sup 2} high heat flux. Also, this system will be used to test other PFCs for ITER and materials for tokamak reactors. Korean high heat flux test facility(KoHLT-EB; Korea Heat Load Test facility - Electron Beam) by using an electron beam system has been constructed in KAERI to perform the qualification test for ITER blanket FW semi-prototype mockups, hypervapotron cooling devices in fusion devices, and other ITER plasma facing components. The commissioning and performance tests with the supplier of e-gun system have been performed on November 2012. The high heat flux test for hypervapotron cooling device and calorimetry were performed to measure the surface heat flux, the temperature profile and cooling performance. Korean high heat flux test facility for the plasma facing components of nuclear fusion machines will be constructed to evaluate the performance of each component. This facility for the plasma facing materials will be equipped with an electron beam system with a 60 kV acceleration gun.

  19. Extension of Ko Straight-Beam Displacement Theory to Deformed Shape Predictions of Slender Curved Structures

    Science.gov (United States)

    Ko, William L.; Fleischer, Van Tran

    2011-01-01

    The Ko displacement theory originally developed for shape predictions of straight beams is extended to shape predictions of curved beams. The surface strains needed for shape predictions were analytically generated from finite-element nodal stress outputs. With the aid of finite-element displacement outputs, mathematical functional forms for curvature-effect correction terms are established and incorporated into straight-beam deflection equations for shape predictions of both cantilever and two-point supported curved beams. The newly established deflection equations for cantilever curved beams could provide quite accurate shape predictions for different cantilever curved beams, including the quarter-circle cantilever beam. Furthermore, the newly formulated deflection equations for two-point supported curved beams could provide accurate shape predictions for a range of two-point supported curved beams, including the full-circular ring. Accuracy of the newly developed curved-beam deflection equations is validated through shape prediction analysis of curved beams embedded in the windward shallow spherical shell of a generic crew exploration vehicle. A single-point collocation method for optimization of shape predictions is discussed in detail

  20. Rate constant and thermochemistry for K + O2 + N2 = KO2 + N2

    DEFF Research Database (Denmark)

    Sorvajärvi, Tapio; Viljanen, Jan; Toivonen, Juha;

    2015-01-01

    The addition reaction of potassium atoms with oxygen has been studied using the collinear photofragmentation and atomic absorption spectroscopy (CPFAAS) method. KCl vapor was photolyzed with 266 nm pulses and the absorbance by K atoms at 766.5 nm was measured at various delay times with a narrow...... line width diode laser. Experiments were carried out with O2/N2 mixtures at a total pressure of 1 bar, over 748-1323 K. At the lower temperatures single exponential decays of [K] yielded the third-order rate constant for addition, kR1, whereas at higher temperatures equilibration was observed...... in the form of double exponential decays of [K], which yielded both kR1 and the equilibrium constant for KO2 formation. kR1 can be summarized as 1.07 × 10-30(T/1000 K)-0.733 cm6 molecule-2 s-1. Combination with literature values leads to a recommended kR1 of 5.5 × 10-26T-1.55 exp(-10/T) cm6 molecule-2 s-1...

  1. Slope Stability Estimation of the Kościuszko Mound in Cracow

    Directory of Open Access Journals (Sweden)

    Wrana Bogumił

    2015-06-01

    Full Text Available In the paper, the slope stability problem of the Kościuszko Mound in Cracow, Poland is considered. The slope stability analysis was performed using Plaxis FEM program. The outer surface of the mound has complex geometry. The slope of the cone is not uniform in all directions, on the surface of the cone are pedestrian paths. Due to its complicated geometry it was impossible to do computing by Plaxis input pre-procesor. The initial element mesh was generated using Autodesk Autocad 3D and next it was updated by Plaxis program. The soil parameters were adopted in accordance with the detailed geological soil testing performed in 2012. Calculating model includes geogrids. The upper part was covered by MacMat geogrid, while the lower part of the Mound was reinforced using Terramesh Matt geogrid. The slope analysis was performed by successives reduction of φ /c parameters. The total multiplayer ΣMsf is used to define the value of the soil strength parameters. The article presents the results of slope stability before and after the rainfall during 33 days of precipitation in flood of 2010.

  2. ECU tendon &apos;'dislocation'&apos; in asymptomatic volunteers

    Energy Technology Data Exchange (ETDEWEB)

    Petchprapa, Catherine N. [New York University Langone Medical Center, Hospital for Joint Diseases, Department of Radiology, New York, NY (United States); Meraj, Seema [Zwanger-Pesiri Radiology Group, Lindenhurst, NY (United States); Jain, Nidhi [New York University School of Medicine, New York University Langone Medical Center, Department of Radiology, New York, NY (United States)

    2016-06-15

    Assess extensor carpi ulnaris (ECU) tendon position in the ulnar groove, determine the frequency of tendon &apos;'dislocation'&apos; with the forearm prone, neutral, and supine, and determine if an association exists between ulnar groove morphology and tendon position in asymptomatic volunteers. Axial proton density-weighted MR was performed through the distal radioulnar joint with the forearm prone, neutral, and supine in 38 asymptomatic wrists. The percentage of the tendon located beyond the ulnar-most border of the ulnar groove was recorded. Ulnar groove depth and length was measured and ECU tendon signal was assessed. 15.8 % of tendons remained within the groove in all forearm positions. In 76.3 %, the tendon translated medially from prone to supine. The tendon &apos;'dislocated'&apos; in 0, 10.5, and 39.5 % with the forearm prone, neutral and supine, respectively. In 7.9 % prone, 5.3 % neutral, and 10.5 % supine exams, the tendon was 51-99 % beyond the ulnar border of the ulnar groove. Mean ulnar groove depth and length were 1.6 and 7.7 mm, respectively, with an overall trend towards greater degrees of tendon translation in shorter, shallower ulnar grooves. The ECU tendon shifts in a medial direction when the forearm is supine; however, tendon &apos;'dislocation'&apos; has not been previously documented in asymptomatic volunteers. The ECU tendon medially translated or frankly dislocated from the ulnar groove in the majority of our asymptomatic volunteers, particularly when the forearm is supine. Overall greater degrees of tendon translation were observed in shorter and shallower ulnar grooves. (orig.)

  3. Human apoB contributes to increased serum total apo(a level in LPA transgenic mice

    Directory of Open Access Journals (Sweden)

    Teivainen Päivi A

    2004-05-01

    Full Text Available Abstract Background The Lp(a lipoprotein (Lp(a consists of the polymorphic glycoprotein apolipoprotein(a (apo(a, which is attached by a disulfide bond to apolipoprotein B (apoB. Apo(a, which has high homology with plasminogen, is present only in primates and hedgehogs. However, transgenic mice and rabbits with high serum apo(a levels exist. Liver is the main site for apo(a synthesis, but the site of removal is uncertain. To examine differences between transgenic mice expressing the LPA gene and mice capable of forming Lp(a particles, LPA-YAC transgenic mice and hAPOB transgenic mice were crossed and their offspring examined. Results Comparison of LPA-YAC with LPA-YAC/hAPOB transgenic mice showed that LPA-YAC/hAPOB transgenic mice have higher serum total apo(a and total cholesterol level than mice lacking the hAPOB gene. However, hepatic apo(a mRNA level was higher in LPA-YAC transgenic mice than in LPA-YAC/hAPOB transgenic mice. Feeding of a high-cholesterol/high-fat diet to male LPA-YAC transgenic mice with or without the hAPOB gene resulted in reduced serum total apo(a and hepatic apo(a mRNA level. Conclusion In conclusion, the higher serum total apo(a level in LPA-YAC/hAPOB transgenic mice than in LPA-YAC transgenic mice is not caused by increased apo(a synthesis. Lower hepatic apo(a mRNA level in LPA-YAC/hAPOB than in LPA-YAC transgenic mice may suggest that the increase in total apo(a level is a result of apo(a accumulation in serum. Furthermore, observed higher serum total cholesterol level in LPA-YAC/hAPOB transgenic mice than either in wild type or LPA-YAC transgenic mice may further suggest that human APOB transgenicity is a factor that contributes to increased serum total apo(a and cholesterol levels. Our results on reduced serum total apo(a and hepatic apo(a mRNA levels in HCHF fed male LPA-YAC transgenic mice confirm earlier findings in females, and show that there are no sex difference in mechanisms for lowering apo(a level in

  4. Implications of effects &apos;&apos;adaptive response&apos;&apos;, &apos;&apos;low-dose hypersensitivity&apos;&apos; und &apos;&apos;bystander effect&apos;&apos; for cancer risk at low doses and low dose rates; Implikationen der Effekte &apos;&apos;adaptive response&apos;&apos;, &apos;&apos;low-dose hypersensitivity&apos;&apos; und &apos;&apos;bystander effect&apos;&apos; fuer das Krebsrisiko bei niedrigen Dosen und Dosenraten

    Energy Technology Data Exchange (ETDEWEB)

    Jacob, P (comp.)

    2006-07-01

    A model for carcinogenesis (the TSCE model) was applied in order to examine the effects of &apos;&apos;Low-dose hypersensitivity (LDH)&apos;&apos; and the &apos;&apos;Bystander effect (BE)&apos;&apos; on the derivation of radiation related cancer mortality risks. LDH has been discovered to occur in the inactivation of cells after acute exposure to low LET radiation. A corresponding version of the TSCE model was applied to the mortality data on the Abomb survivors from Hiroshima and Nagasaki. The BE has been mainly observed in cells after exposure to high LET radiation. A Version of the TSCE model which included the BE was applied to the data on lung cancer mortality from the workers at the Mayak nuclear facilities who were exposed to Plutonium. In general an equally good description of the A-bomb survivor mortality data (for all solid, stomach and lung tumours) was found for the TSCE model and the (conventional) empirical models but fewer parameters were necessary for the TSCE model. The TSCE model which included the effects of radiation induced cell killing resulted in non-linear dose response curves with excess relative risks after exposure at young ages that were generally lower than in the models without cell killing. The main results from TSCE models which included cell killing described by either conventional survival curves or LDH were very similar. A sub multiplicative effect from the interaction of smoking and exposure to plutonium was found to result from the analysis of the Mayak lung cancer mortality data. All models examined resulted in the predominant number of Mayak lung cancer deaths being ascribed to smoking. The interaction between smoking and plutonium exposures was found to be the second largest effect. The TSCE model resulted in lower estimates for the lung cancer excess relative risk per unit plutonium dose than the empirical risk model, but this difference was not found to be statistically significant. The excess relative risk dose responses

  5. The human apoE7 and apoE4 transgenic mice models

    Institute of Scientific and Technical Information of China (English)

    孙明增; 琦祖和

    2001-01-01

    To scrutinize the disorders caused by human mutant apoE7/apoE4, human apoE4 and E7 transgenic mice were established with microinjection technique to examine molecular genetic phenomena in vivo. The integration and expression of h-apoE mutant genes in transgenic mice were determined with Southern blot, Northern blot and ELISA. The current studies indicated that the transgenes and the phenotypes regarding expression of transgenes could be transmitted stably in transgenic lines. The levels of serum lipid in transgenic mice showed the characteristics of hyperlipidemia. Besides, behavior tests demonstrated the degeneration of learning and memory in transgenic mice. Short life span was observed in 2 transgenic lines. After fed with high lipid food high serum lipid was found both in normal and transgenic mice, but their mechanism regulating lipid metabolism was different. It was also verified that the human apoE mutants located at either N-terminal or C-terminal had the same pathogenesis regarding disorders of lipid metabolism in murine.

  6. Coral bleaching and ocean &apos;&apos;hot spots&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Goreau, T.J. (Global Coral Reef Alliance, Chappaqua, NY (United States)); Hayes, R.L. (Howard Univ., Washington, DC (United States). College of Medicine)

    1994-05-01

    Global sea-surface temperature maps show that mass coral-reef bleaching episodes between 1983 and 1991 followed positive anomalies more than 1 deg C above long-term monthly averages (&apos;&apos;hot spots&apos;&apos;) during the preceding warm season. Irregular formation, movement, and disappearance of hot spots make their detailed long-term prediction impossible, but they can be tracked in real time from satellite data. Monitoring of ocean hot spots and of coral bleaching is needed if the Framework Convention of Climate Change is to meet its goal of protecting the most temperature sensitive ecosystems. 47 refs, 3 figs

  7. Heavy cluster decay of trans-zirconium &apos;'stable'&apos; nuclides

    Energy Technology Data Exchange (ETDEWEB)

    Poenaru, D.N.; Greiner, W.; Ivascu, M.; Sandulescu, A.

    1985-12-01

    By using the analytical superasymmetric fission model it is shown that all &apos;'stable'&apos; nuclei lighter than lead with Z>40 are metastable relative to the spontaneous emission of nuclear clusters. An even-odd effect is included in the zero point vibration energy. Half-lives in the range 10/sup 40/--10/sup 50/ s are obtained for Z>62. The region of metastability against these new decay modes is extended beyond that for ..cap alpha.. decay and in some cases, in the competing region, the emission rates for nuclear clusters are larger than for ..cap alpha.. decay.

  8. Improved Security Via &apos;&apos;Town Crier&apos;&apos; Monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Johnston, R. G.; Garcia, A. R. E.; Pacheco, A. N.

    2003-02-26

    Waste managers are increasingly expected to provide good security for the hazardous materials they marshal. Good security requires, among other things, effective tamper and intrusion detection. We have developed and demonstrated a new method for tamper and intrusion detection which we call the &apos;&apos;town crier method&apos;&apos;. It avoids many of the problems and vulnerabilities associated with traditional approaches, and has significant advantages for hazardous waste transport. We constructed two rudimentary town crier prototype systems, and tested them for monitoring cargo inside a truck. Preliminary results are encouraging.

  9. Focus on &apos;&apos;regulation management&apos;&apos;. Information material - documentation; Brennpunkt &apos;'Regulierungsmanagement'&apos;. Materialienband

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    With the new Energy Economy Act coming into force and regulation authorities being established, the public utilities providing gas and electricity are starting the implementation of regulation. This creates a new field of activity: The regulation management. The regulation manager in a public utility has a wide field of functions. He or she is responsible for the organisation of the enterprise with regard to the regulation authority. He must coordinate various divisions of the enterprise taking into consideration the interest of the regulation authority and take steps to form a common understanding. The meeting called &apos;&apos;Focus on Regulation Management&apos;&apos; provides an insight into the most important tasks of a regulation manager, giving information useful for establishing an efficient regulation management system. In the first part of the meeting, the basics and tasks of regulation management and the legal protection towards the regulation authorities are dealt with. Furthermore, the president of the states&apos; committee in the BNetzA, Mr. Peter Franke, will introduce the present fields of activity, reporting about first experiences gained with the network cost requests. In the second part, practitioners from the enterprises report about their experiences with the implementation of regulation management. This includes especially data management, an effective reporting system and the implementation of a relationship management between the regulation authority and the enterprise. The meeting closes with a speech on the subject of comparing methods and benchmarking in the network.

  10. Do we need a &apos;&apos;green medicine&apos;&apos;?; Brauchen wir &apos;&apos;Gruene Medizin?&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, M.; Daschner, F.; Scherrer, M. [Universitaetsklinikum Freiburg (Germany)

    2006-07-01

    Spontaneously, we do associate &apos;&apos;green medicine&apos;&apos; with terms like naturopathy, natural healing substances, herbal active agents, homeopathy, healthy food, preventive medicine and similar things, and finally we think of ecology. This is the focus of the following article. First of all, the following question arises: Are there any environment-friendly and cost-saving alternatives to the present medicine? There is an increasing number of environment-caused diseases. Therefore, a medicine not coping with the environment is not credible. In today&apos;s medicine, for example, there are too many persistent detergents, water-polluting disinfectants, and many disposable materials. Too much water ist consumed, whereas the use of renewable energies is only limited. And too little natural healing methods are applied in diagnostics and therapy. Presently, in Germany, 16,7 million in-patients are treated in Germany, 1,16 million out-patients have surgeries in 2166 hospitals by ca. 1,1 million medical staff. All this work needs energy and materials which bring various risks to environment and the patients. During the last two decades, however, many efforts were made in the field of environment protection in medicine. There is hardly a hospital left which has not taken measures of protecting the environment. In the branch-specific quality management system KTQ (=cooperation for transparency and quality in the health system). environment protection measures are interrogated and systematically assessed.

  11. The &apos;mini&apos; and &apos;micro&apos; energy sources and their limitations; Les &apos;'minis'&apos; et &apos;'micros'&apos; sources d&apos;energie et leurs limites

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2004-03-01

    The &apos;Science and defense 2003&apos; colloquium took place in Paris on December 2 and 3. It was organized by the general delegation of armament (DGA), the French atomic energy commission (CEA) with the participation of the national center of scientific research (CNRS) and the French ministry of research and new technologies. The main topic was the needs and the solutions implemented in the domain of energy sources both for civil and military portable applications. This article make a general summary of the content of this colloquium only in the domain of small power energy sources: emergence of new miniaturized portable devices (phones, computers, cameras, autonomous medical systems, wireless communication systems, soldiers equipments, drones etc..), improvement of batteries energy density and price, new needs linked with new functionalities, technological challenges (energy generation and recovery systems, miniaturized fuel-cells, use of recoverable energy sources, implantation of power sources in the human body etc..), new technological files (new electrode materials, micron- or sub-micron scale mechanical and electronic components, sensors, micro-motors, transfer of microelectronics technologies, hybrid systems..), international competition. (J.S.)

  12. CT evaluation of Chamberlain&apos;s, McGregor&apos;s, and McRae&apos;s skull-base lines

    Energy Technology Data Exchange (ETDEWEB)

    Cronin, C.G. [Department of Radiology, University College Hospital, Galway (Ireland)], E-mail: carmelcronin2000@hotmail.com; Lohan, D.G.; Mhuircheartigh, J.N.; Meehan, C.P.; Murphy, J.; Roche, C. [Department of Radiology, University College Hospital, Galway (Ireland)

    2009-01-15

    Aim: To evaluate the mean distance from the odontoid process of C2 to the standard skull-base lines (Chamberlain&apos;s, McGregor&apos;s, and McRae&apos;s lines) on computed tomography (CT) imaging. To compare these measurements to previously documented plain radiograph and magnetic resonance imaging (MRI) measurements. Materials and methods: Reformatted midline sagittal CT images of 150 adults were retrospectively evaluated. The shortest perpendicular distance was measured from the Chamberlain&apos;s, McGregor&apos;s and McRae&apos;s baselines for each subject to the odontoid tip. Statistical analysis was performed to compare the CT data with the previously obtained MRI and plain film data. Results: The mean position of the odontoid process was 1.4 mm below Chamberlain&apos;s line (median 1.2 mm, SD 2.4 mm), 0.8 mm (median 0.9 mm, SD 3 mm) below McGregor&apos;s line and 5 mm (median 5 mm, SD 1.8 mm) below McRae&apos;s line. There is no significant difference between male and female results (p > 0.05) or between these CT and previous MRI measurements (p > 0.05). Conclusion: These results provide the mean and range of normal distance from the odontoid process to the most frequently used skull-base lines on the current population on CT.

  13. The German &apos;'Energiewende'&apos;. Evaluation after the Paris-agreement; Die Deutsche Energiewende. Bewertung nach dem Klima-Abkommen von Paris

    Energy Technology Data Exchange (ETDEWEB)

    Roth, Eike

    2016-12-15

    The World-Climate-Summit 2016 in Paris agreed to exacerbated goals for climate protection. This paper will scrutinize whether Germany can comply with its Paris-obligations by continuing the ongoing German &apos;'Energiewende'&apos;. The result is clear-cut: The German &apos;'Energiewende'&apos; is inadequate. Due to the cap-and-trade system of the EU the &apos;'Energiewende'&apos; can in no way contribute to climate protection.

  14. GPR21 KO mice demonstrate no resistance to high fat diet induced obesity or improved glucose tolerance [version 1; referees: 1 approved, 2 approved with reservations

    Directory of Open Access Journals (Sweden)

    Jinghong Wang

    2016-02-01

    Full Text Available Gpr21 KO mice generated with Gpr21 KO ES cells obtained from Deltagen showed improved glucose tolerance and insulin sensitivity when fed a high fat diet. Further mRNA expression analysis revealed changes in Rabgap1 levels and raised the possibility that Rabgap1 gene may have been modified. To assess this hypothesis a new Gpr21 KO mouse line using TALENS technology was generated. Gpr21 gene deletion was confirmed by PCR and Gpr21 and Rabgap1 mRNA expression levels were determined by RT-PCR. The newly generated Gpr21 KO mice when fed a normal or high fat diet chow did not maintain their improved metabolic phenotype. In conclusion, Rabgap1 disturbance mRNA expression levels may have contributed to the phenotype of the originally designed Gpr21 KO mice.

  15. GPR21 KO mice demonstrate no resistance to high fat diet induced obesity or improved glucose tolerance [version 2; referees: 1 approved, 2 approved with reservations

    Directory of Open Access Journals (Sweden)

    Jinghong Wang

    2016-06-01

    Full Text Available Gpr21 KO mice generated with Gpr21 KO ES cells obtained from Deltagen showed improved glucose tolerance and insulin sensitivity when fed a high fat diet. Further mRNA expression analysis revealed changes in Rabgap1 levels and raised the possibility that Rabgap1 gene may have been modified. To assess this hypothesis a new Gpr21 KO mouse line using TALENS technology was generated. Gpr21 gene deletion was confirmed by PCR and Gpr21 and Rabgap1 mRNA expression levels were determined by RT-PCR. The newly generated Gpr21 KO mice when fed a normal or high fat diet chow did not maintain their improved metabolic phenotype. In conclusion, Rabgap1 disturbance mRNA expression levels may have contributed to the phenotype of the originally designed Gpr21 KO mice.

  16. Performance of &apos;'ductless'&apos; personalized ventilation in conjunction with displacement ventilation: Impact of intake height

    Energy Technology Data Exchange (ETDEWEB)

    Halvonova, Barbora [Department of Building Services, Slovak University of Technology in Bratislava, 813 68 Bratislava (Slovakia); International Centre for Indoor Environment and Energy, Department of Civil Engineering, Technical University of Denmark (Denmark); Melikov, Arsen K. [International Centre for Indoor Environment and Energy, Department of Civil Engineering, Technical University of Denmark (Denmark)

    2010-04-15

    The importance of the intake positioning height above the floor level on the performance of &apos;'ductless'&apos; personalized ventilation (&apos;'ductless'&apos; PV) in conjunction with displacement ventilation (DV) was examined with regard to the quality of inhaled air and of the thermal comfort provided. A typical office room with two workstations positioned one behind the other was arranged in a full-scale room. Each workstation consisted of a table with an installed &apos;'ductless'&apos; PV system, PC, desk lamp and seated breathing thermal manikin. The &apos;'ductless'&apos; PV system sucked the clean and cool displacement air supplied over the floor at four different heights, i.e. 2, 5, 10 and 20 cm and transported it direct to the breathing level. Moreover, two displacement airflow rates were used with a supply temperature adjusted in order to maintain an exhaust air temperature of 26 C. Two pollution sources, namely air exhaled by one of the manikins and passive pollution on the table in front of the same manikin were simulated by constant dosing of tracer gases. The results show that the positioning of a &apos;'ductless'&apos; PV intake height up to 0.2 m above the floor will not significantly influence the quality of inhaled air and thermal comfort. (author)

  17. &apos;&apos;Measuring the Costs of Climate Change Policies&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Montgomery, W. D.; Smith, A. E.; Biggar, S. L.; Bernstein, P.M.

    2003-05-09

    Studies of the costs of climate change policies have utilized a variety of measures or metrics for summarizing costs. The leading economic models have utilized GNP, GDP, the &apos;&apos;area under a marginal cost curve,&apos;&apos; the discounted present value of consumption, and a welfare measure taken directly from the utility function of the model&apos;s representative agent (the &apos;&apos;Equivalent Variation&apos;&apos;). Even when calculated using a single model, these metrics do not necessarily give similar magnitudes of costs or even rank policies consistently. This paper discusses in non-technical terms the economic concepts lying behind each concept, the theoretical basis for expecting each measure to provide a consistent ranking of policies, and the reasons why different measures provide different rankings. It identifies a method of calculating the &apos;&apos;Equivalent Variation&apos;&apos; as theoretically superior to the other cost metrics in ranking policies. When regulators put forward new economic or regulatory policies, there is a need to compare the costs and benefits of these new policies to existing policies and other alternatives to determine which policy is most cost-effective. For command and control policies, it is quite difficult to compute costs, but for more market-based policies, economists have had a great deal of success employing general equilibrium models to assess a policy&apos;s costs. Not all cost measures, however, arrive at the same ranking. Furthermore, cost measures can produce contradictory results for a specific policy. These problems make it difficult for a policy-maker to determine the best policy. For a cost measures to be of value, one would like to be confident of two things. First one wants to be sure whether the policy is a winner or loser. Second, one wants to be confident that a measure produces the correct policy ranking. That is, one wants to have confidence in a policy measure&apos;s ability to correctly rank

  18. Nuclear waste disposal. A wicked and highly conflict bearing societal problem; Nukleare Entsorgung. Ein &apos;'wicked'&apos; und hoechst konfliktbehaftetes Gesellschaftsproblem

    Energy Technology Data Exchange (ETDEWEB)

    Brunnengraeber, Achim; Mez, Lutz [Freie Univ. Berlin (Germany). Forschungszentrum fuer Umweltpolitik; Di Nucci, Maria Rosaria; Schreuers, Miranda [Freie Univ. Berlin (Germany)

    2012-12-15

    The final disposal of nuclear wastes is called &apos;'messy'&apos; or &apos;'wicked'&apos; in the political science literature. The highly complicated problems are characterized by a number of features such as intra- and inter-generational aspects and ethical questions. In the case of stakeholders the differences concern ideologies, interests, merits and preferences that cause conflicts. The search for solutions is complicated due to interacting political, social, ecologic, economic and technical aspects. The concepts &apos;&apos;wicked problems&apos;&apos; and &apos;'multi-level-governance'&apos; are promising approaches to solve the complicated situation.

  19. ELABORATION OF NOT LARGE MOBILE MODULAR INSTALLATION &apos;&apos;AQUA - EXPRESS&apos;&apos; (300 L/H) FOR LRW CLEANING

    Energy Technology Data Exchange (ETDEWEB)

    Karlin, Yurii; Dmitriev, Sergey; Iljin, Vadim; Ojovan, Mihail; Burcl, Rudolf

    2003-02-27

    Mobile modular installation &apos;'Aqua-Express'&apos; is a liquid low level and intermediate level radioactive waste (LL&ILRW) treatment facility, intended for not large research centers and other organizations, which activity causes the formation of a few quantity (up to 500 m3/year) of low and intermediate level radioactive waste water. Mobile modular installation &apos;'Aqua-Express'&apos; has the following features: (1) filtration, sorption and ultrafiltration units are used for LL&ILRW purification; (2) installation &apos;'Aqua-Express'&apos; consists of a cascade of three autonomous aqueous liquid waste-purifying installations; (3) installation &apos;'Aqua-Express'&apos; is a mobile installation; the installation can be transported by car, train, ship, or plane, as well as placed in a standard transport (sea or railway) container; (4) installation &apos;'Aqua-Express'&apos; does not includes any technological equipment for conditioning the secondary radioactive waste. Productivity of the installation &apos;'Aqua-Express'&apos; by purified water depends on composition of the initial liquid waste and makes up to 300 l/h. In present report is described the design of installation &apos;'Aqua-Express'&apos;, theory of LRW purification in the installation &apos;'Aqua-Express'&apos; and some results of its use at cleaning real radioactive waters at State unitary enterprise - MosNPO &apos;'Radon'&apos;.

  20. &apos;Teleparallel&apos; dark energy

    Energy Technology Data Exchange (ETDEWEB)

    Geng, Chao-Qiang, E-mail: geng@phys.nthu.edu.tw [Department of Physics, National Tsing Hua University, Hsinchu 300, Taiwan (China); National Center for Theoretical Sciences, Hsinchu 300, Taiwan (China); Lee, Chung-Chi, E-mail: g9522545@oz.nthu.edu.tw [Department of Physics, National Tsing Hua University, Hsinchu 300, Taiwan (China); Saridakis, Emmanuel N., E-mail: Emmanuel_Saridakis@baylor.edu [CASPER, Physics Department, Baylor University, Waco, TX 76798-7310 (United States); National Center for Theoretical Sciences, Hsinchu 300, Taiwan (China); Wu, Yi-Peng, E-mail: s9822508@m98.nthu.edu.tw [Department of Physics, National Tsing Hua University, Hsinchu 300, Taiwan (China)

    2011-10-25

    Using the &apos;teleparallel&apos; equivalent of General Relativity as the gravitational sector, which is based on torsion instead of curvature, we add a canonical scalar field, allowing for a nonminimal coupling with gravity. Although the minimal case is completely equivalent to standard quintessence, the nonminimal scenario has a richer structure, exhibiting quintessence-like or phantom-like behavior, or experiencing the phantom-divide crossing. The richer structure is manifested in the absence of a conformal transformation to an equivalent minimally-coupled model.

  1. Functional characterization of ent-kaurene oxidase, MtKO, from Montanoa tomentosa (Zoapatle

    Directory of Open Access Journals (Sweden)

    Villa-Ruano Nemesio

    2015-01-01

    Full Text Available Kaurene oxidases are P450 proteins that catalyze the conversion of ent-kaurene into kaurenoic acid, the final enzymatic product with a wide range of pharmacological properties. We describe the functional characterization of an ent-kaurene oxidase (EC 1.14.13.78 isolated from Montanoa tomentosa after heterologous expression in Saccharomyces cerevisiae, as well as the detection of the enzymatic activity in the plant itself. In the presence of NADPH and FAD, the microsomal fraction from transformed INVSc1 cells, ent-kaurene produced ent-kaurenoic acid, which was confirmed by GC-MS analyses. The kinetic parameters for ent-kaurene using 0.5 mg of microsomal protein were Km app= 80.63±1.2 μM and V max app= 31.80±1.8 μmol-1mg-1h-1. Optimal temperature and pH were 30°C and 7.6, respectively. Similar kinetic parameters were observed when leaf microsomes from M. tomentosa were assayed under the same conditions as for yeast microsomes. This result strongly suggests that ent-kaurene oxidase activity is present in leaf microsomes. The enzymatic activity was competitively inhibited by paclobutrazol, with IC50=43.9 μM, implying that MtKO is resistant to inhibition by azolic-type compounds. This study confirmed the biochemical detection of ent-kaurene oxidase activity in the plant, and the heterologous functionality of a cDNA with an ent-kaurene oxidase identity from M. tomentosa (zoapatle.

  2. Etiology and implications of dense cavitary &apos;'photopenia'&apos; on myocardial perfusion scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Dae, M.; Canhasi, B.; Botvinick, E.; Olvera, S.; Schechtmann, N.; Engelstad, B.; Hattner, R.; Schiller, N.; O' Connell, W.; Faulkner, D.

    1985-07-01

    Dense cavitary &apos;'photopenia'&apos; was observed on 21 of 200 consecutive stress perfusion scintigrams. A prominent finding in many cases, it sometimes occupied only a portion of the region overlying the ventricular cavity, was often seen in some projections and not others, and was frequently adjacent to myocardial perfusion defects. To distinguish an etiology among reduced cavitary radioactivity, relatively increased background radioactivity, or reduced radioactivity in overlying myocardium, quantitative analysis of cavitary, lung and myocardial radioactivity was performed in patients with dense cavitary &apos;'photopenia,'&apos; with and without lung uptake, and compared with results from studies showing increased lung uptake without cavitary photopenia and with normal studies. The results showed that dense cavitary photopenia was related to reduced radioactivity in overlying myocardium. Correlative imaging studies performed with echocardiography and contrast ventriculography confirmed this relationship to myocardial scar in 15 of 21 patients in whom associated akinesis or dyskinesis was seen. Hence, dense cavitary photopenia on stress perfusion scintigraphy is due to a dense myocardial perfusion abnormality, and is often indicative of related scar and an associated severe contraction abnormality.

  3. Considerations about the apparent &apos;&apos;superluminal expansions&apos;&apos; observed in astrophysics

    Energy Technology Data Exchange (ETDEWEB)

    Recami, E.; Castellino, A.; Maccarrone, G.D.; Rodono, M.

    1986-06-11

    The orthodox models devised to explain the apparent &apos;&apos;superluminal expansions&apos;&apos; observed in astrophysics - and here briefly summarized and discussed together with the experimental data - do not seem to be too much successful, especially when confronted with the most recent observations, suggesting complicated expansion patterns, even with possible accelerations. At this point it may be, therefore, of some interest to explore the possible alternative models in which actual Superluminal motions take place. To prepare the ground, we start from a variational principle, introduce the elements of a tachyon mechanics within special relativity, and argue about the expected behaviour of tachyonic objects when interacting (gravitationally, for instance) among themselves or with ordinary matter. We then review and develop the simplet &apos;&apos;Superluminal models&apos;&apos;, paying particular attention to the observations which they would give rise to. We conclude that some of them appear to be physically acceptable and are statistically favoured with respect to the orthodox ones.

  4. Effect of Cyp27A1 gene dosage on atherosclerosis development in ApoE-knockout mice.

    Science.gov (United States)

    Zurkinden, Line; Solcà, Curzio; Vögeli, Isabelle A; Vogt, Bruno; Ackermann, Daniel; Erickson, Sandra K; Frey, Felix J; Sviridov, Dmitri; Escher, Geneviève

    2014-03-01

    In humans, sterol 27-hydroxylase (CYP27A1) deficiency leads to cholesterol deposition in tendons and vasculature. Thus, in addition to its role in bile acid synthesis, where it converts cholesterol to 27-hydroxycholesterol (27-OHC), CYP27A1 may also be atheroprotective. Cyp27A1-deficient (Cyp27A1(-/-)) mice were crossed with apolipoprotein E (apoE)-deficient mice. Cyp27A1(+/+)/apoE(-/-) [ApoE-knockout (KO)], Cyp27A1(+/-)/apoE(-/-) heterozygous (het), and Cyp27A1(-/-)/apoE(-/-) [double-knockout (DKO)] mice were challenged with a Western diet (WD) for 3 and 6 mo. ApoE-KO mice fed a chow diet or a WD were used as the control. The severity of atherosclerosis in DKO mice was reduced 10-fold. Compared with the control, the DKO mice had no 27-OHC, total plasma cholesterol and low-density lipoprotein and very low density lipoprotein (LDL/VLDL) concentrations were reduced 2-fold, and HDL was elevated 2-fold. Expression of hepatic CYP7A1, CYP3A, and CYP8B1 were 5- to 10-fold higher. 3-Hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) activity increased 4-fold. Fecal cholesterol was increased. In contrast, het mice fed a WD developed accelerated atherosclerosis and severe skin lesions, possibly because of reduced reverse cholesterol transport due to diminished 27-OHC production. CYP27A1 activity is involved in the control of cholesterol homeostasis and development of atherosclerosis with a distinct gene dose-dependent effect.

  5. &apos;'VaneCAM'&apos; - the third generation of camshaft adjustment systems; &apos;'VaneCAM'&apos; - Nockenwellenversteller der dritten Generation

    Energy Technology Data Exchange (ETDEWEB)

    Knecht, A. [Hydraulik-Ring GmbH, Nuertingen (Germany). Entwicklung Motorentechnik; Stephan, W. [Hydraulik-Ring GmbH, Nuertingen (Germany); Hannibal, W. [Fachhochschule Suedwestfalen, Iserlohn (Germany). Labor fuer Konstruktion und CAE-Anwendungen

    2002-04-01

    Continuously variable camphasers are now well established for modern spark-ignition engines in high-volume production. With the latest generation of camshaft adjustment systems using the vane-type actuator principle, it is possible to move rapidly and reliably through a large adjustment angle. The layout of these adjusting systems is very simple. The production costs are low in comparison to the first generation of camphasers using spur/helical gears to vary the valve timing. The new-generation systems are mechatronic, with the function depending on the coordination and tuning of hydraulic actuation and engine electronics. The term &apos;VaneCAM&apos; is used for the continuously variable systems of this new generation supplied by Hydraulik-Ring in Nuertingen, Germany. (orig.) [German] Stufenlos wirkende Nockenwellenversteller haben sich an modernen Ottomotoren in den letzten Jahren in der Grossserie etabliert. Mit der neuesten Generation von Nockenwellenverstellern, die nach dem Schwenkmotor-Prinzip aufgebaut sind, lassen sich grosse Verdrehwinkel sehr schnell und betriebssicher verstellen. Der Aufbau dieser Versteller ist einfach, und die Herstellkosten sind gering im Vergleich zur ersten Generation von Verstellern. Bei den Systemen der neuen Generation handelt es sich um mechatronische Systeme, deren Funktion von dem Zusammenspiel und der Abstimmung von hydraulischer Ansteuerung und Motorelektronik abhaengt. Mit dem Begriff &apos;VaneCAM&apos; werden die stufenlos wirkenden Systeme dieser neuen Generation von Hydraulik-Ring aus Nuertingen bezeichnet. (orig.)

  6. Preparation of data relevant to &apos;&apos;Equivalent Uniform Burnup&apos;&apos; and Equivalent Initial Enrichment&apos;&apos; for burnup credit evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Nomura, Yasushi; Okuno, Hiroshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Murazaki, Minoru [Tokyo Nuclear Service Inc., Tokyo (Japan)

    2001-11-01

    Based on the PWR spent fuel composition data measured at JAERI, two kinds of simplified methods such as &apos;&apos;Equivalent Uniform Burnup&apos;&apos; and &apos;&apos;Equivalent Initial Enrichment&apos;&apos; have been introduced. And relevant evaluation curves have been prepared for criticality safety evaluation of spent fuel storage pool and transport casks, taking burnup of spent fuel into consideration. These simplified methods can be used to obtain an effective neutron multiplication factor for a spent fuel storage/transportation system by using the ORIGEN2.1 burnup code and the KENO-Va criticality code without considering axial burnup profile in spent fuel and other various factors introducing calculated errors. &apos;&apos;Equivalent Uniform Burnup&apos;&apos; is set up for its criticality analysis to be reactivity equivalent with the detailed analysis, in which the experimentally obtained isotopic composition together with a typical axial burnup profile and various factors such as irradiation history are considered on the conservative side. On the other hand, Equivalent Initial Enrichment&apos;&apos; is set up for its criticality analysis to be reactivity equivalent with the detailed analysis such as above when it is used in the so called fresh fuel assumption. (author)

  7. Excessive sympathoactivation and deteriorated heart function after myocardial infarction in male ghrelin knockout mice.

    Science.gov (United States)

    Mao, Yuanjie; Tokudome, Takeshi; Otani, Kentaro; Kishimoto, Ichiro; Miyazato, Mikiya; Kangawa, Kenji

    2013-05-01

    We have previously demonstrated the protective role of endogenous ghrelin against malignant arrhythmias in the very acute phase of myocardial infarction (MI). However, the role of endogenous ghrelin in the chronic phase is unknown. Therefore, the aim of the current study was to focus on the effects of endogenous ghrelin on cardiac function and sympathetic activation after acute MI. In 46 ghrelin-knockout (KO) and 41 wild-type (WT) male mice, MI was produced by left coronary artery ligation. The mortality due to heart failure within 2 weeks was 0% in WT and 10.9% in KO (P Metoprolol treatment and ghrelin treatment in KO mice prevented excessive sympathetic activation, decreased plasma epinephrine and norepinephrine levels, and improved heart function and survival rate after MI. Our data demonstrate that endogenous ghrelin plays a crucial role in protecting heart function and reducing mortality after myocardial infarction, and that these effects seem to be partly the result of sympathetic inhibition.

  8. Source of spill ripple in the RF-KO slow-extraction method with FM and AM

    CERN Document Server

    Noda, K; Shibuya, S; Muramatsu, M; Uesugi, T; Kanazawa, M; Torikoshi, M; Takada, E; Yamada, S

    2002-01-01

    The RF-knockout (RF-KO) slow-extraction method with frequency modulation (FM) and amplitude modulation (AM) has brought high-accuracy irradiation to the treatment of a cancer tumor moving with respiration, because of a quick response to beam start/stop. However, a beam spill extracted from a synchrotron ring through RF-KO slow-extraction has a huge ripple with a frequency of around 1 kHz related to the FM. The spill ripple will disturb the lateral dose distribution in the beam scanning methods. Thus, the source of the spill ripple has been investigated through experiments and simulations. There are two tune regions for the extraction process through the RF-KO method: the extraction region and the diffusion region. The particles in the extraction region can be extracted due to amplitude growth through the transverse RF field, only when its frequency matches with the tune in the extraction region. For a large chromaticity, however, the particles in the extraction region can be extracted through the synchrotron ...

  9. A Spectroscopic Study of the Algol-type Binaries S Equulei and KO Aquilae: Absolute Parameters and Mass Transfer

    CERN Document Server

    Soydugan, F; Soydugan, E; Catalano, S; Demircan, O; Ibanoglu, C

    2007-01-01

    We present and analyze high-resolution optical spectra of the Algol binaries S Equ and KO Aql. New accurate radial velocities for the hotter primary components are obtained. Thanks to the cross-correlation procedure, we were able to measure, for the first time to our knowledge, radial velocities also for the cool secondary components of S Equ and KO Aql. By combining the parameters obtained from the solution of the radial velocity curves with those obtained from the light curve analysis, reliable absolute parameters of the systems have been derived. The rotational velocity of the hotter components of S Equ and KO Aql has been measured and it is found that the gainers of both systems rotate about 30 % faster than synchronously. This is likely due to mass transfer across the Lagrangian L1 point from the cooler to the hotter component. The lower luminosity of the mass-gaining components of these systems compared to normal main-sequence stars of the same mass can be also an effect of the mass transfer. The H-alph...

  10. Citation analysis of The Korean Journal of Internal Medicine from KoMCI, Web of Science, and Scopus.

    Science.gov (United States)

    Huh, Sun

    2011-03-01

    The Korean Journal of Internal Medicine (KJIM) is the international journal published in English by the Korean Association of Internal Medicine. To understand the position of the journal in three different databases, the citation indicators were elucidated. From databases such as Korean Medical Citation Index (KoMCI), Web of Science, and Scopus, citation indicators such as the impact factor, SCImago journal rank (SJR), or Hirsch Index were calculated according to the year and the results were drawn. The KJIM 2010 impact factor increased to 0.623 in Web of Science. That of year 2009 in KoMCI was a 0.149. The 2009 SJR in Scopus was 0.073, with a ranking of 27/72 (37.5%) in the category of internal medicine and 414/1,618 (25.6%) in the category of medicine, miscellaneous. The Hirsch Index from KoMCI, Web of Science and Scopus were 5, 14, and 16, respectively. The KJIM is now cited more by international researchers than Korean researchers, indicating that the content of the journal is now valued at the international level.

  11. Density, porosity and magnetic susceptibility of the Ko\\v{s}ice meteorite shower and homogeneity of its parent meteoroid

    CERN Document Server

    Kohout, Tomáš; Tóth, Juraj; Husárik, Marek; Gritsevich, Maria; Britt, Daniel; Borovička, Jiří; Spurný, Pavel; Igaz, Antal; Svoreň, Ján; Kornoš, Leonard; Vereš, Peter; Koza, Július; Zigo, Pavol; Gajdoš, Štefan; Világi, Jozef; Čapek, David; Krišandová, Zuzana; Tomko, Dušan; Šilha, Jiří; Schunová, Eva; Bodnárová, Marcela; Búzová, Diana; Krejčová, Tereza

    2014-01-01

    Bulk and grain density, porosity, and magnetic susceptibility of 67 individuals of Ko\\v{s}ice H chondrite fall were measured. The mean bulk and grain densities were determined to be 3.43 g/cm$^\\text{3}$ with standard deviation (s.d.) of 0.11 g/cm$^\\text{3}$ and 3.79 g/cm$^\\text{3}$ with s.d. 0.07 g/cm$^\\text{3}$, respectively. Porosity is in the range from 4.2 to 16.1%. The logarithm of the apparent magnetic susceptibility (in 10$^\\text{-9}$ m$^\\text{3}$/kg) shows narrow distribution from 5.17 to 5.49 with mean value at 5.35 with s.d. 0.08. These results indicate that all studied Ko\\v{s}ice meteorites are of the same composition down to ~g scale without presence of foreign (non-H) clasts and are similar to other H chondrites. Ko\\v{s}ice is thus a homogeneous meteorite fall derived from a homogeneous meteoroid.

  12. CAV_KO: a Simple 1-D Langrangian Hydrocode for MS EXCEL™ with Automatic Generation of X-T Diagrams

    Science.gov (United States)

    Tsembelis, K.; Ramsden, B.; Proud, W. G.; Borg, J.

    2007-12-01

    Hydrocodes are widely used to predict or simulate highly dynamic and transient events such as blast and impact. Codes such as GRIM, CTH or AUTODYN are well developed and involve complex numerical methods and in many cases require a large computing infrastructure. In this paper we present a simple 1-D Langrangian hydrocode developed at the University of Cambridge, called CAV_KO written in Visual Basic. The motivation being to produce a code which, while being relatively simple, is useful for both experimental planning and teaching. The code has been adapted from the original KO code written in FORTRAN by J. Borg, which, in turn, is based on the algorithm developed by Wilkins [1]. The developed GUI within MS Excel™ and the automatic generation of x-t diagrams allow CAV_KO to be a useful tool for quick calculations of plate impact events and teaching purposes. The VB code is licensed under the GNU General Public License and a MS Excel™ spreadsheet containing the code can be downloaded from www.shockphysics.com together with a copy of the user guide.

  13. Echium Oil Reduces Plasma Triglycerides by Increasing Intravascular Lipolysis in apoB100-Only Low Density Lipoprotein (LDL Receptor Knockout Mice

    Directory of Open Access Journals (Sweden)

    John S. Parks

    2013-07-01

    Full Text Available Echium oil (EO, which is enriched in SDA (18:4 n-3, reduces plasma triglyceride (TG concentrations in humans and mice. We compared mechanisms by which EO and fish oil (FO reduce plasma TG concentrations in mildly hypertriglyceridemic male apoB100-only LDLrKO mice. Mice were fed one of three atherogenic diets containing 0.2% cholesterol and palm oil (PO; 20%, EO (10% EO + 10% PO, or FO (10% FO + 10% PO. Livers from PO- and EO-fed mice had similar TG and cholesteryl ester (CE content, which was significantly higher than in FO-fed mice. Plasma TG secretion was reduced in FO vs. EO-fed mice. Plasma very low density lipoprotein (VLDL particle size was ordered: PO (63 ± 4 nm > EO (55 ± 3 nm > FO (40 ± 2 nm. Post-heparin lipolytic activity was similar among groups, but TG hydrolysis by purified lipoprotein lipase was significantly greater for EO and FO VLDL compared to PO VLDL. Removal of VLDL tracer from plasma was marginally faster in EO vs. PO fed mice. Our results suggest that EO reduces plasma TG primarily through increased intravascular lipolysis of TG and VLDL clearance. Finally, EO may substitute for FO to reduce plasma TG concentrations, but not hepatic steatosis in this mouse model.

  14. Echium oil reduces plasma triglycerides by increasing intravascular lipolysis in apoB100-only low density lipoprotein (LDL) receptor knockout mice.

    Science.gov (United States)

    Forrest, Lolita M; Lough, Christopher M; Chung, Soonkyu; Boudyguina, Elena Y; Gebre, Abraham K; Smith, Thomas L; Colvin, Perry L; Parks, John S

    2013-07-12

    Echium oil (EO), which is enriched in SDA (18:4 n-3), reduces plasma triglyceride (TG) concentrations in humans and mice. We compared mechanisms by which EO and fish oil (FO) reduce plasma TG concentrations in mildly hypertriglyceridemic male apoB100-only LDLrKO mice. Mice were fed one of three atherogenic diets containing 0.2% cholesterol and palm oil (PO; 20%), EO (10% EO + 10% PO), or FO (10% FO + 10% PO). Livers from PO- and EO-fed mice had similar TG and cholesteryl ester (CE) content, which was significantly higher than in FO-fed mice. Plasma TG secretion was reduced in FO vs. EO-fed mice. Plasma very low density lipoprotein (VLDL) particle size was ordered: PO (63 ± 4 nm) > EO (55 ± 3 nm) > FO (40 ± 2 nm). Post-heparin lipolytic activity was similar among groups, but TG hydrolysis by purified lipoprotein lipase was significantly greater for EO and FO VLDL compared to PO VLDL. Removal of VLDL tracer from plasma was marginally faster in EO vs. PO fed mice. Our results suggest that EO reduces plasma TG primarily through increased intravascular lipolysis of TG and VLDL clearance. Finally, EO may substitute for FO to reduce plasma TG concentrations, but not hepatic steatosis in this mouse model.

  15. Production of intermediate vector meson resonances in the process {tau}{yields}{pi}&apos;'{+-}{pi}'&apos;0{nu}

    Energy Technology Data Exchange (ETDEWEB)

    Casaus, J.; Mana, C.

    1997-07-01

    We present a study on the invariant mass distribution of {pi}&apos;'{+-}{pi}'&apos;0 pairs produced in the process {tau}{yields}{pi}&apos;'{+-}{pi}'&apos;0{nu} . The analysis is based on a sample of 33,096 events collected by the L3 detector between 1991 and 1994. The data is not inconsistent with the hypothesis that the process is being mediated by the p(770) meson alone but is in better agreement with the inclusion of an extra {rho} resonance in the decay of the tau lepton. (Author) 10 refs.

  16. Novel action of apolipoprotein E (ApoE: ApoE isoform specifically inhibits lipid-particle-mediated cholesterol release from neurons

    Directory of Open Access Journals (Sweden)

    Fujita Shinobu C

    2007-05-01

    Full Text Available Abstract Background Since the majority of apolipoprotein E (apoE existing in the cerebrospinal fluid is associated with high-density lipoprotein (HDL, one should focus on the role of the apoE-HDL complex rather than on that of free apoE in cholesterol metabolism in the central nervous system. However, the apoE-isoform-specific effect of apoE-HDL on cholesterol transport remains unclarified. Results Here we show that apoE3-HDL induced a marked cholesterol release from neurons, while apoE4-HDL induced little. To elucidate the mechanism underlying this phenomenon, we used a complex of lipid emulsion (EM with recombinant apoE3 or apoE4 (apoE-EM at various apoE concentrations. When a small number of apoE molecules were associated with EM, apoE3- and apoE4-EM, induced a marked cholesterol release to a level similar to that induced by EM alone. However, when apoE at given concentrations was incubated with EM, apoE3-EM induced a marked cholesterol release, while apoE4-EM induced little. Under these conditions, a greater number of apoE4 molecules were associated with EM than apoE3 molecules. When an increasing number of apoE molecules were associated with EM, both apoE3-EM and apoE4-EM induced little cholesterol release. Preincubation with β-mercaptoethanol increased the number of apoE3 molecules associated with EM similar to that of apoE4 molecules, indicating that the presence (apoE3 or absence (apoE4 of intermolecular disulfide bond formation is responsible for the association of a greater number of apoE4 molecules to EM than apoE3 molecules. Conclusion These results suggest that although apoE and a lipid particle are lipid acceptors, when apoE and a lipid particle form a complex, apoE on the particle surface inhibits the lipid particle-mediated cholesterol release from cells in an apoE-concentration-dependent manner.

  17. Orbit as a Mirror of Systemic Disease; &apos;&apos; Epidemiologic, Clinical and Imaging &apos;&apos;

    Directory of Open Access Journals (Sweden)

    Aliakbar Ameri

    2009-01-01

    Full Text Available   "n1- Infectious: toxoplasmosis , toxocariasis ,TB , syphilis , leprosy , HIV , CMV. "n2- Non infectous: endocrine, diabetes, thyroid, connective tissue disease &apos;&apos;RA, SLE, wegeners, PAN, systemic sclerosis&apos;&apos;, vasculitides, GCA&apos;&apos;, sarcoidosis, behcet&apos;s disease, vogt koyangi harada syndrome, phakomatoses. "nAll diseases should be demonstrated by clinical images and imaging slides. "n-imaging "nX-RAY, high frequency US and color doppler, 2D and 3D X-RAY CT, MRI: "n1- X-RAY: in fractures, foreign bodies, skull combined anomalies and few other cases. "n2-High-frequency ultrasound for posterior chamber and ciliary body micro-anatomic changes &apos;&apos; tumors granulations&apos;&apos;. "nColor Doppler study for vascular lesions, central retin artery, tumors in the globe and retrobulbar region. "n3- X-RAY CT for tumors, 2D and 3D for fractures, 3D for bone anatomy, foreign body &apos;&apos; modality of choice is 2directional 2D CT scan &apos;&apos;, sino-nasal diseases, CT-angiography or phlebography in large vessel evaluation, DSA for small vessel anatomy. "n4- MRI for tumors and infection also granulation process. "nMRI and MRV in large vessel anatomy, functional – MRI for the visual pathway, tractography. "nConclusion : "nModality of choice : "n1- CT for foreign bodies &apos;&apos; MRI is contra-indicated in the first step specially in metallic fragments &apos;&apos;. CT for micro-calcification &apos;&apos; retinoblastoma &apos;&apos;,CT for fractures. "n2- MRI for tumors, biometry, soft tissue disease and functional imaging. "n3- DSA for vascular disease of the eye. "n4- U.S for biometery, posterior Chamber, iris and ciliary body lesions. 5- Fluorescein angiography for the retina.  

  18. Isparta Koşullarında Kanola (Brassica napus L. Çeşitlerinin

    Directory of Open Access Journals (Sweden)

    H Baydar

    2009-04-01

    Full Text Available Kanola (kolza, tohumlarında %40-50 arasında yağ bulunan, oleik asitçe zengin değerli bir yağ bitkisidir. Bu araştırmada; 00 tipi (yağında %2'den az erusik asit ve 1 gram kuru küspesinde 30 μmol'ün altında glukosinolat içeren 15 kanola çeşidinin (Bienvenue, Bristol, Cascade, Colombus, Eurol, Honk, Liborius, Ninetta, Lirawell, Monitta, Quinta, Semu-86/225 Na, Synergy, Tarok ve Westar Isparta koşullarında verim ve kalite özellikleri belirlenmiştir. Tarla denemesi, 2000/2001 yetiştirme sezonunda Süleyman Demirel Üniveristesi Ziraat Fakültesi Tarla Bitkileri Bölümü deneme tarlasında Tesadüf Blokları Deneme Deseni'nde 3 tekerrürlü olarak kurulmuştur. Araştırmada, soxhlet ve GC teknikleri yardımıyla yağ oranları ve yağ asitleri kompozisyonları (palmitik asit, stearik asit, oleik asit, linoleik asit ve linolenik asit saptanmıştır. En yüksek tohum verimi Tarok (287.2 kg/da çeşidinden ve en düşük tohum verimi Bienvenue (218.0 kg/da çeşidinden elde edilmiştir. Kanola çeşitlerinin yağ oranı değerleri %35.4-44.4 arasında değişmiştir. Kanola yağında %5.3-7.0 arasında palmitik asit, %1.0-4.3 arasında stearik asit, %66.6-74.4 arasında oleik asit, %14.1-19.7 linoleik asit ve %1.8-6.0 arasında linolenik asit bulunduğu saptanmıştır. Hiçbir çeşidin yağında erusik asit varlığına rastlanmamıştır.

  19. Effects of genistein and estrogen receptor subtype-specific agonists in ArKO mice following different administration routes.

    Science.gov (United States)

    Bliedtner, Anja; Zierau, Oliver; Albrecht, Steffen; Liebhaber, Steffi; Vollmer, Günter

    2010-01-15

    We have scrutinized the effects of the phytoestrogen genistein and three synthetic estrogen receptor agonists, 17 alpha-ethynylestradiol (EE), propylpyrazole-triol (PPT) and diarylpropionitrile (DPN) in the completely estrogen-free background of aromatase knockout (ArKO) mice by means of two routes of substance administration: oral via diet (per os; po) or subcutaneous injection (sc) with the intention to evaluate the ArKO mice as sensitive model organism for uterotrophic assays. Additionally, we were aiming to qualitatively analyze effects resulting from oral administration path, in particular for PPT and DPN. Therefore, we analyzed the resulting uterine wet weights (UWW) and epithelial heights as physiological endpoints of function as well as the gonadotropin levels. Moreover, the gene expression profiles of estrogen receptors as well as important uterine and ovarian estrogen-response genes were investigated by real-time PCR. The uterus of ArKO mice responded very sensitive upon the substitution with EE (sc 5 microg/kg BW; po 50 microg/kg BW) in a proliferative manner. This was evaluated inter alia by increased UWW and by up-regulation of the expression of proliferation-associated and estrogen-response genes. It is important to note, that ER alpha and ER beta-agonist, PPT and DPN respectively (po 5mg/kg BW and sc 0.5mg/kg BW), have only been used for sc applications so far. Here, effects resulting from oral application were qualitatively described and evaluated for their applicability. The UWW and expression of proliferation-associated genes were increased following both po and sc treatment with PPT. In contrast, DPN did not exert an increase of the UWW, but a significant decrease of proliferation-associated gene and protein expression. Additionally, a substantial hypoplasia was detectable in the uterine cross-sections of DPN-treated mice. On the other hand, the phytoestrogen genistein (sc 10mg/kg BW; po 70 mg/kg BW) did not cause detectable uterotrophic

  20. A &apos;'Toolbox'&apos;21 Equivalent Process for Safety Analysis Software

    Energy Technology Data Exchange (ETDEWEB)

    O' KULA, KR

    2004-04-30

    Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 2002-1 (Quality Assurance for Safety-Related Software) identified a number of quality assurance issues on the use of software in Department of Energy (DOE) facilities for analyzing hazards, and designing and operating controls that prevent or mitigate potential accidents. The development and maintenance of a collection, or &apos;'toolbox,'&apos; of multiple-site use, standard solution, Software Quality Assurance (SQA)-compliant safety software is one of the major improvements identified in the associated DOE Implementation Plan (IP). The DOE safety analysis toolbox will contain a set of appropriately quality-assured, configuration-controlled, safety analysis codes, recognized for DOE-broad, safety basis applications. Currently, six widely applied safety analysis computer codes have been designated for toolbox consideration. While the toolbox concept considerably reduces SQA burdens among DOE users of these codes, many users of unique, single-purpose, or single-site software may still have sufficient technical justification to continue use of their computer code of choice, but are thwarted by the multiple-site condition on toolbox candidate software. The process discussed here provides a roadmap for an equivalency argument, i.e., establishing satisfactory SQA credentials for single-site software that can be deemed &apos;'toolbox-equivalent'&apos;. The process is based on the model established to meet IP Commitment 4.2.1.2: Establish SQA criteria for the safety analysis &apos;'toolbox'&apos; codes. Implementing criteria that establish the set of prescriptive SQA requirements are based on implementation plan/procedures from the Savannah River Site, also incorporating aspects of those from the Waste Isolation Pilot Plant (SNL component) and the Yucca Mountain Project. The major requirements are met with evidence of a software quality assurance plan, software requirements and

  1. Is Cass&apos;s Model of Homosexual Identity Formation Relevant to Today&apos;s Society?

    Science.gov (United States)

    Kenneady, Donna Ann; Oswalt, Sara B.

    2014-01-01

    Cass&apos;s Homosexual Identity Formation Model (1979) is one of the most well-known and well-referenced models of identity development for gay males and lesbians. This article provides a review of Cass&apos;s six steps of the model, as well as research support for and critiques of the model. As the model was developed more than 30 years ago, the…

  2. &apos;'Beaded'&apos; osteoid osteoma: a possible transition between solitary and multicentric tumor

    Energy Technology Data Exchange (ETDEWEB)

    Chiou, Yi-You [Department of Radiology, Taipei Veterans General Hospital, 201 Sec. 2 Shih-Pai Road, 11217, Taipei (Taiwan); Rosenthal, Daniel I. [Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 (United States); Rosenberg, Andrew E. [Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 (United States)

    2003-07-01

    An extremely rare example of an elongated (3 cm) osteoid osteoma is presented. The tumor demonstrated three focal enlargements connected by narrow areas, suggesting a &apos;&apos;string of beads&apos;&apos; in appearance. The elongated shape suggested the possibility that lesional tissue was stretched in a longitudinal fashion as a result of the rapid skeletal growth. The tumor closest to the growth plate was densely ossified, while the furthest lesion was almost completely lytic, suggesting that the tumor enlarged in a centripetal direction. This case is believed to illustrate a continuum from solitary to multicentric osteoid osteoma. The tumor was treated successfully with three separate percutaneous radiofrequency ablations during a single session. (orig.)

  3. Radmap: &apos;'as-built'&apos; cad models incorporating geometrical, radiological and material information

    Energy Technology Data Exchange (ETDEWEB)

    Piotrowski, L. [Electricite de France (EDF/DRD), 78 - Chatou (France); Lubawy, J.L. [Electricite de France (EDF/CNEPE), 37 - Tours (France)

    2001-07-01

    EDF intends to achieve successful and cost-effective dismantling of its obsolete nuclear plants. To reach this goal, EDF is currently extending its &apos;'as-built'&apos; 3-D modelling system to also include the location and characteristics of gamma sources in the geometrical models of its nuclear installations. The resulting system (called RADMAP) is a complete CAD chain covering 3-D and gamma data acquisitions, CAD modelling and exploitation of the final model. Its aim is to describe completely the geometrical and radiological state of a particular nuclear environment. This paper presents an overall view of RADMAP. The technical and functional characteristics of each element of the chain are indicated and illustrated using real (EDF) environments/applications. (author)

  4. APOE Genotyping, Cardiovascular Disease

    Science.gov (United States)

    ... Home Visit Global Sites Search Help? APOE Genotyping, Cardiovascular Disease Share this page: Was this page helpful? Also ... of choice to decrease the risk of developing cardiovascular disease (CVD) . However, there is a wide variability in ...

  5. Major disruption of D&apos;&apos; beneath Alaska: D&apos;&apos; Beneath Alaska

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Daoyuan [Laboratory of Seismology and Physics of Earth' s Interior, School of Earth and Space Sciences, University of Science and Technology of China, Hefei Anhui China; National Geophysics Observatory at Mengcheng, Anhui China; Helmberger, Don [Seismological Laboratory, California Institute of Technology, Caltech, Pasadena California USA; Miller, Meghan S. [Department of Earth Sciences, University of Southern California, Los Angeles California USA; Jackson, Jennifer M. [Seismological Laboratory, California Institute of Technology, Caltech, Pasadena California USA

    2016-05-01

    D&apos;&apos; represents one of the most dramatic thermal and compositional layers within our planet. In particular, global tomographic models display relatively fast patches at the base of the mantle along the circum-Pacific which are generally attributed to slab debris. Such distinct patches interact with the bridgmanite (Br) to post-bridgmanite (PBr) phase boundary to generate particularly strong heterogeneity at their edges. Most seismic observations for the D&apos;&apos; come from the lower mantle S wave triplication (Scd). Here we exploit the USArray waveform data to examine one of these sharp transitions in structure beneath Alaska. From west to east beneath Alaska, we observed three different characteristics in D&apos;&apos;: (1) the western region with a strong Scd, requiring a sharp δVs = 2.5% increase; (2) the middle region with no clear Scd phases, indicating a lack of D&apos;&apos; (or thin Br-PBr layer); and (3) the eastern region with strong Scd phase, requiring a gradient increase in δVs. To explain such strong lateral variation in the velocity structure, chemical variations must be involved. We suggest that the western region represents relatively normal mantle. In contrast, the eastern region is influenced by a relic slab that has subducted down to the lowermost mantle. In the middle region, we infer an upwelling structure that disrupts the Br-PBr phase boundary. Such an interpretation is based upon a distinct pattern of travel time delays, waveform distortions, and amplitude patterns that reveal a circular-shaped anomaly about 5° across which can be modeled synthetically as a plume-like structure rising about 400 km high with a shear velocity reduction of ~5%, similar to geodynamic modeling predictions of upwellings.

  6. THE FIRST &apos;&apos;WATER FOUNTAIN&apos;&apos; COLLIMATED OUTFLOW IN A PLANETARY NEBULA

    Energy Technology Data Exchange (ETDEWEB)

    Gómez, José F.; Miranda, Luis F.; Guerrero, Martín A. [Instituto de Astrofísica de Andalucía, CSIC, Glorieta de la Astronomía s/n, E-18008 Granada (Spain); Suárez, Olga; Bendjoya, Philippe; Lagadec, Eric [Laboratoire Lagrange, UMR 7293, Université de Nice Sophia-Antipolis, CNRS, Observatoire de la Côte d' Azur, F-06304 Nice (France); Rizzo, J. Ricardo; García-García, Enrique [Centro de Astrobiología (INTA-CSIC), Ctra. M-108, km. 4, E-28850 Torrejón de Ardoz (Spain); Green, James A. [CSIRO Astronomy and Space Science, Australia Telescope National Facility, P.O. Box 76, Epping, NSW 1710 (Australia); Uscanga, Lucero [Institute of Astronomy, Astrophysics, Space Applications and Remote Sensing, National Observatory of Athens, 15236 Athens (Greece); Ramos-Larios, Gerardo [Instituto de Astronomía y Meteorología, Av. Vallarta No. 2602, Col. Arcos Vallarta, C.P. 44130 Guadalajara, Jalisco (Mexico)

    2015-02-01

    &apos;&apos;Water fountains&apos;&apos; (WFs) are evolved objects showing high-velocity, collimated jets traced by water maser emission. Most of them are in the post-asymptotic giant branch (post-AGB) and they may represent one of the first manifestations of collimated mass loss in evolved stars. We present water maser, carbon monoxide, and mid-infrared spectroscopic data (obtained with the Australia Telescope Compact Array, Herschel Space Observatory, and the Very Large Telescope, respectively) toward IRAS 15103–5754, a possible planetary nebula (PN) with WF characteristics. Carbon monoxide observations show that IRAS 15103–5754 is an evolved object, while the mid-IR spectrum displays unambiguous [Ne II] emission, indicating that photoionization has started and thus, its nature as a PN is confirmed. Water maser spectra show several components spreading over a large velocity range (≅ 75 km s{sup –1}) and tracing a collimated jet. This indicates that the object is a WF, the first WF known that has already entered the PN phase. However, the spatial and kinematical distribution of the maser emission in this object are significantly different from those in other WFs. Moreover, the velocity distribution of the maser emission shows a &apos;'Hubble-like'&apos; flow (higher velocities at larger distances from the central star), consistent with a short-lived, explosive mass-loss event. This velocity pattern is not seen in other WFs (which are presumably in earlier evolutionary stages). We therefore suggest that we are witnessing a fundamental change of mass-loss processes in WFs, with water masers being pumped by steady jets in post-AGB stars, but tracing explosive/ballistic events as the object enters the PN phase.

  7. Trends in Energy. &apos;The consumer decides&apos;; Trends in Energy. &apos;De consument bepaalt&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Brzezowsky-Ruys, Y.; Van der Zalm, M.; Van Zutphen, M. (eds.)

    2012-03-15

    A report is given of the Capgemini organised congress &apos;Trends in Energy 2011&apos; which has the Dutch subtitle &apos;De consument bepaalt&apos; (The consumer decides&apos;. The focus of the articles, interviews, debates and presentations is on the role of the consumer in the supply of and demand for energy. Parts of the report are in Dutch and English [Dutch] Dit rapport bestaat uit een verslag van het congres &apos;Trends in Energy 2011. De consument bepaalt&apos; en een aantal artikelen met achtergrondinformatie over onder meer de rol van de consument in vraag en aanbod van energie.

  8. APOE AND ALZHEIMER DISEASE: A MAJOR GENE WITH SEMI-DOMINANT INHERITANCE

    Science.gov (United States)

    Genin, Emmanuelle; Hannequin, Didier; Wallon, David; Sleegers, Kristel; Hiltunen, Mikko; Combarros, Onofre; Bullido, Maria J; Engelborghs, Sebastiaan; De Deyn, Peter; Berr, Claudine; Pasquier, Florence; Dubois, Bruno; Tognoni, Gloria; Fiévet, Nathalie; Brouwers, Nathalie; Bettens, Karolien; Arosio, Beatrice; Coto, Eliecer; Zompo, Maria Del; Mateo, Ignacio; Epelbaum, Jacques; Frank-Garcia, Ana; Helisalmi, Seppo; Porcellini, Elisa; Pilotto, Alberto; Forti, Paola; Ferri, Raffaele; Scarpini, Elio; Siciliano, Gabriele; Solfrizzi, Vincenzo; Sorbi, Sandro; Spalletta, Gianfranco; Valdivieso, Fernando; Vepsäläinen, Saila; Alvarez, Victoria; Bosco, Paolo; Mancuso, Michelangelo; Panza, Francesco; Nacmias, Benedetta; Bossù, Paola; Hanon, Olivier; Piccardi, Paola; Annoni, Giorgio; Seripa, Davide; Galimberti, Daniela; Licastro, Federico; Soininen, Hilkka; Dartigues, Jean-François; Kamboh, M Ilyas; Van Broeckhoven, Christine; Lambert, Jean Charles; Amouyel, Philippe; Campion, Dominique

    2011-01-01

    Apolipoprotein E (APOE) dependent lifetime risks (LTRs) for Alzheimer Disease (AD) are currently not accurately known and odds ratios (ORs) alone are insufficient to assess these risks. We calculated AD lifetime risk in 7,351 cases and 10,132 controls from Caucasian ancestry using Rochester (USA) incidence data. At the age of 85 the LTR of AD without reference to APOE genotype was 11% in males and 14% in females. At the same age, this risk ranged from 51% for APOE44 male carriers to 60% for APOE44 female carriers, and from 23% for APOE34 male carriers to 30% for APOE34 female carriers, consistent with semi-dominant inheritance of a moderately penetrant gene. Using PAQUID (France) incidence data, estimates were globally similar except that at age 85 the LTRs reached 68% and 35 % for APOE 44 and APOE 34 female carriers, respectively. These risks are more similar to those of major genes in Mendelian diseases, such as BRCA1 in breast cancer, than those of low-risk common alleles identified by recent GWAS in complex diseases. In addition, stratification of our data by age- groups clearly demonstrates that APOE4 is a risk factor not only for late- onset but for early- onset AD as well. Together, these results urge a reappraisal of the impact of APOE in Alzheimer disease. PMID:21556001

  9. VRŠNJAČKO NASILJE MEĐU DJEVOJČICAMA

    Directory of Open Access Journals (Sweden)

    Iva Prpić

    2006-12-01

    Full Text Available Cilj ovoga rada je širenje spoznaja o vršnjačkom nasilju isključivo među djevojčicama, relacijskoj agresiji i posebnim metodama koje djevojčice koriste. Iako postoji općeprihvaćena znanstvena teorija o različitostima socijalizacije i razvoja dječaka i djevojčica, još uvijek se nasilje među djecom promatra jednoobrazno i kroz dimenziju fizičkog nasilja koje uglavnom počinjavaju dječaci.U radu se najprije daju opće definicije nasilja među djecom, karakteristike tog nasilja te posebna obilježja nasilnika i žrtve.Nakon općeg dijela, rad se usredotočuje na vršnjačko nasilje među djevojčicama te se pokušava objasniti zbog čega to nasilje nikad nije bilo u fokusu istraživačkog interesa. Posebna je pozornost posvećena relacijskoj agresiji u kojoj se šteti drugima »kroz povredu« (ili prijetnju povredom veze ili osjećaja prihvaćenosti, prijateljstva ili uključenosti u grupu. Navedene su poruke koje društvo šalje djevojčicama i lista karakteristika koju posjeduje svaka »idealna djevojčica«, odnosno »antidjevojčica«. Rad obrađuje i posebne metode koje djevojčice koriste jedna protiv druge te se objašnjava i pojam cyberbullyinga kao novoga vida nasilja među djecom, te pogotovo među djevojčicama. Nadalje, rad obrađuje dva istraživanja u suvremenoj hrvatskoj praksi o nasilju među djecom (Poliklinika za zaštitu djece Grada Zagreba te UNICEF. Ta istraživanja rad tretira s aspekta nasilja među djevojčicama i prezentira razlike u vršenju nasilja među spolovima. U završnom dijelu rada obrađuju se dokumenti Republike Hrvatske u borbi protiv vršnjačkog nasilja i to »Program aktivnosti za sprječavanje nasilja među djecom i mladima« te »Protokol o postupanju u slučaju nasilja među djecom i mladima«. Analizom dokumenata pokušava se ukazati na nerazlikovanje posebnog vida nasilja koje vrše isključivo djevojčice.

  10. Paternal uniparental disomy 14: introducing the &apos;coat-hanger&apos; sign

    Energy Technology Data Exchange (ETDEWEB)

    Offiah, Amaka C. [Institute of Child Health, 30 Guilford Street, London (United Kingdom); Department of Radiology, Great Ormond Street Hospital for Children, London WC1 N 3JH (United Kingdom); Cornette, Luc [Peter Congdon Neonatal Intensive Care Unit, Clarendon Wing, Leeds General Infirmary, Leeds (United Kingdom); Hall, Christine M. [Department of Radiology, Great Ormond Street Hospital for Children, London WC1 N 3JH (United Kingdom)

    2003-07-01

    Paternal uniparental disomy for chromosome 14 (patUPD14) is a rare condition, this being the eighth report. A male infant, born prematurely, was noted to have extremely lax skin and bilateral inguinal hernias. Skin biopsy confirmed the clinical diagnosis of congenital cutis laxa, but this did not explain the limb abnormalities. Radiographic findings (particularly the &apos;coat-hanger&apos; configuration of the ribs on the chest radiograph), suggested a diagnosis of patUPD14, which was confirmed following DNA analysis. The patient died after prolonged respiratory failure. This combination of patUPD14 and congenital cutis laxa has not previously been described. Radiology can play a pivotal role in guiding the geneticist&apos;s choice of investigation. (orig.)

  11. Exposure to CB-153 and p,p&apos;-DDE and human sperm chromatin integrity

    Energy Technology Data Exchange (ETDEWEB)

    Rignell-Hydbom, A.; Rylander, L.; Joensson, B.A.G.; Hagmar, L. [Dept. of Occupational and Environmental Medicine, Lund Univ. Hospital (Sweden); Giwercman, A. [Fertility Centre, Malmoe Univ. hospital (Sweden); Spano, M. [Section of Toxicology and Biomedical Sciences, ENEA Casaccia Research Centre, Rome (Italy)

    2004-09-15

    In Sweden, the consumption of fatty fish from the Baltic Sea (off the Swedish east coast) is the single most important source of exposure to persistent organochlorine pollutants (POPs). Fishermen from the east coast have averagely higher plasma levels of polychlorinated biphenyls (PCBs) and total POP derived TEQ in plasma than both west coast fishermen and men from the general population. Dichlorodiphenyl dichloroethene (p,p&apos;-DDE), a relevant biomarker for POP is still present in relatively high serum concentrations in men consuming fish from the Baltic Sea. Several studies have shown that POPs are capable of interfering with reproductive and endocrine function in animals. Human studies have shown that exposure to PCBs and polychlorinated dibenzofurans (PCDFs) has a negative effect on male reproductive function, and especially sperm motility seems vulnerable. However, studies relating to human sperm genetic integrity are few. The aim of the study was to investigate whether exposure to POP using 2,2&apos;,4,4&apos;,5,5&apos;- hexachlorobiphenyl (CB-153) and p,p&apos;-DDE as biomarkers, are associated with sperm chromatin integrity. In order to ensure a sufficient variation in POP exposure fishermen from both the Swedish east (&apos;&apos;more exposed&apos;&apos;) and west coasts (&apos;&apos;less exposed&apos;&apos;) formed the study base.

  12. Kidney-specific upregulation of vitamin D3 target genes in ClC-5 KO mice.

    Science.gov (United States)

    Maritzen, T; Rickheit, G; Schmitt, A; Jentsch, T J

    2006-07-01

    Mutations in ClC-5 cause Dent's disease, a disorder associated with low molecular weight proteinuria, hyperphosphaturia, and kidney stones. ClC-5 is a Cl(-)/H(+)-exchanger predominantly expressed in the kidney, where it facilitates the acidification of proximal tubular endosomes. The reduction in proximal tubular endocytosis resulting from a lack of ClC-5 raises the luminal concentration of filtered proteins and peptides like parathyroid hormone (PTH). The increase in PTH may explain the hyperphosphaturia observed in Dent's disease. Expression profiling, quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR), and hormone measurements were used to investigate whether the disruption of ClC-5 affects other signalling pathways. Although the upregulation of 25(OH)(2)-vitamin D(3) 1alpha-hydroxylase and downregulation of vitamin D(3) 24-hydroxylase suggested an increased formation of 1,25(OH)(2)-vitamin D(3), the concentration of this active metabolite was reduced in the serum of ClC-5 knockout (KO) mice. However, target genes of 1,25(OH)(2)-vitamin D(3) were upregulated in KO kidneys. Expression analysis of intestine and bone revealed that the upregulation of 1,25(OH)(2)-vitamin D(3) target genes was kidney intrinsic and not systemic. In spite of reduced serum levels of 1,25(OH)(2)-vitamin D(3) in ClC-5 KO mice, 1,25(OH)(2)-vitamin D(3) is increased in later nephron segments as a consequence of impaired proximal tubular endocytosis. This leads to a kidney-specific stimulation of 1,25(OH)(2)-vitamin D(3) target genes that may contribute to the pathogenesis of Dent's disease. The activation of genes in distal nephron segments by hormones that are normally endocytosed in the proximal tubule may extend to other pathways like those activated by retinoic acid.

  13. Solid state laser technology for inertial confinement fusion: A collection of articles from &apos;&apos;Energy and Technology Review&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    1988-06-01

    This paper contains reprinted articles that record several milestones in laser research at LLNL. &apos;&apos;Neodymium-Glass Laser Research and Development at LLNL&apos;&apos; recounts the history of the Laser Program and our work on neodymium-glass lasers. &apos;&apos;Nova Laser Technology&apos;&apos; describes the capabilities of the Nova laser and some of its uses. &apos;&apos;Building Nova: Industry Relations and Technology Transfer&apos;&apos; illustrates the Laboratory&apos;s commitment to work with US industry in technology development. &apos;&apos;Managing the Nova Laser Project&apos;&apos; details the organization and close monitoring of costs and schedules during the construction of the Nova laser facility. The article &apos;&apos;Optical Coatings by the Sol-Gel Process,&apos;&apos; describes our chemical process for making the damage-resistant, antireflective silica coatings used on the Nova laser glass. The technical challenges in designing and fabricating the KDP crystal arrays used to convert the light wave frequency of the Nova lasers are reported in &apos;&apos;Frequency Conversion of the Nova Laser.&apos;&apos; Two articles, &apos;&apos;Eliminating Platinum Inclusions in Laser Glass&apos;&apos; and &apos;&apos;Detecting Microscopic Inclusions in Optical Glass,&apos;&apos; describe how we dealt with the problem of damaging metal inclusions in the Nova laser glass. The last article reprinted here, &apos;&apos;Auxilliary Target Chamber for Nova,&apos;&apos; discusses the diversion of two of Nova&apos;s ten beamlines into a secondary chamber for the purpose of increasing our capacity for experimentation.

  14. Switzerland as Europe&apos;s &apos;'battery'&apos;. Wishful dream or reality?; Die Schweiz als &apos;&apos;Batterie Europas&apos;&apos;. Utopie oder Realitaet?

    Energy Technology Data Exchange (ETDEWEB)

    Kammer, Adrian; Zurmuehle, Damian; Salzmann, Michael; Baumgartner, Raphael; Mignone, Domenico [Bernische Kraftwerke (BKW), Bern (Switzerland). Energiewirtschaftliche Planung und Prognose

    2015-04-15

    There are plans for Swiss pumped hydrostorage systems to absorb large quantities of excess electricity from European wind and solar power generation. Model-based analyses have shown however that &apos;'Europe&apos;s battery&apos;&apos;, as Switzerland would like to see itself, will not be needed until the middle of this century. Even if all extension projects currently in progress should be completed, Switzerland will not have sufficient pump capacity or import capacity to absorb large amounts of excess electricity. Furthermore, the primary means of making storage capacity available for import electricity would be to reduce reservoir power plant capacity. In view of all this Switzerland&apos;s hopes for a role as a major European electricity storage provider appear somewhat exaggerated even in the long-term perspective.

  15. Pokretanje doma za starije i nemoćne u Požeško-slavonskoj županiji

    OpenAIRE

    Asančaić, Ana; Plazibat, Olga; Vukoja, Ivan; Vukoja, Marko

    2015-01-01

    Poslovni pothvat izgradnje doma za starije i nemoćne osobe u Požeško-slavonskoj županiji temelji se na demografskom trendu starenja stanovništva i povećanog iseljavanja mladih. Uočena je povećana potreba za odgovarajućim oblicima smještaja starijih i nemoćnih osoba, koji bi korisnike zadovoljavali kvalitetom sadržaja. Na osnovi Porterovog modela pet konkurentskih snaga pokazalo se da je industrija usluge smještaja u dom umjereno atraktivna; za ulazak novih pothvata, zbog prijetnje od ulaska n...

  16. Mito e realtà della letteratura ebraica al femminile in Germania: Anna Seghers e Mascha Kaléko

    Directory of Open Access Journals (Sweden)

    Karin Birge Gilardoni-Büch

    2014-04-01

    Both of them succeed in emigrating and surviving the destruction of the European Jews. Anna Seghers comes back in 1947 to the Soviet occupied zone and will later hold significant offices inside East Germany's cultural life. Mascha Kaléko will however come back only now and then to the German Federal Republic. Did their writing change after the Shoah? And if so, to what extent? Moreover, do the texts mirror the situation in which their authors found themselves? Aren’t they linked to a specific social condition, that of a woman? To what extent do specific female and Jewish experiences take shape in their works?

  17. Kožne promjene kod bolesnika s dijabetesom u Karlovačkoj županiji

    OpenAIRE

    2009-01-01

    Cilj: Istražiti proporciju dermatoza koja su vezane uz diabetes mellitus (DM) i onih koje su nepovezane s njime, proporciju pojedinih skupina u odnosu na ukupan broj dermatoza povezanih s dijabetesom, proporciju s obzirom na spol i proporciju s obzirom na vrstu dijabetesa u pojedinim skupinama. Bolesnici i metode: Retrogradnom studijom obuhvaćeni su bolesnici dijabetološke ambulante pregledani 2007. godine, a imali su kožne promjene i bili na pregledu u dermatološkoj poliklinici. Uku...

  18. Connections of the corticomedial amygdala in the golden hamster. II. Efferents of the &apos;&apos;olfactory amygdala&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Kevetter, G.A.; Winans, S.S.

    1981-03-20

    The anterior cortical (C1) and posterolateral cortical (C2) nuclei of the amygdala are designated the &apos;&apos;olfactory amygdala&apos;&apos; because they each receive direct projections from the main olfactory bulb. The efferents of these nuclei were traced after stereotaxic placement of 1-5 muCi tritiated proline in the corticomedial amygdala of the male golden hamsters. Following survival times of 12, 24, or 48 hours, 20 micron frozen sections of the brains were processed for light microscopic autoradiography. Efferents from C2 terminate in layers II and III of the olfactory tubercle and in layer Ib of pars ventralis and pars medialis of the anterior olfactory nucleus. Fibers from this nucleus also project to layers I and II of the infralimbic cortex and to the molecular layer of the agranular insular cortex. More posteriorly, fibers from C2 terminate in layer I of the dorsolateral entorhinal cortex, and in the endopiriform nucleus. From C1, efferent fibers travel in the stria terminalis and terminate in the precommissural bed nucleus of the stria terminalis and in the mediobasal hypothalamus. Efferents from C1 also innervate the molecular layer of C2, the amygdalo-hippocampal area, and the adjacent piriform cortex. Neurons in both C1 and C2 project to the molecular layer of the medial amygdaloid nucleus and the posteromedial cortical nucleus of the amygdala, the plexiform layer of the ventral subiculum, and the molecular layer of the lateral entorhinal cortex.

  19. Male Osteoporosis

    Directory of Open Access Journals (Sweden)

    Meltem Esenyel

    2004-03-01

    Full Text Available Osteoporosis in men is now recognized as an increasingly important public health issue. About 30 % of hip fractures and 20 % of vertebral fractures occur in men. In the present study, we examined 19 men who did not have major risk factors that might affect bone mass. Parathormone(PTH, osteocalcin (marker of bone formation, OC and deoxypyridinoline (marker of bone resorption, DPD were measured. The bone mineral density (BMD measurements in 16 men were performed by dual-energy X-ray absorbtiometry (DXA from lumbar spine (L2-4, and left hip. Bone density at each site was categorized as osteoporosis or osteopenia according to World Health Organization (WHO criteria. In 19 patients with a mean age of 69 years, PTH levels were in the normal range except one patient. OC levels were elevated in %42.1 and DPD levels were elevated in 74 % of patients. L2-4 T score was osteoporotic (25% in 4 patients and osteopenic (25% in 4 patients. Femur Ward’s T score was osteoporotic (37.5% in 7 patients and osteopenic (37.5% in 7 patients. Osteoporosis is a significant problem in older men. Increased awareness for the risk factors of male osteoporosis is an important issue. Early diagnosis and treatment would help to reduce morbidity and mortality resulting from osteoporotic fractures.

  20. ApoE isoform-dependent changes in hippocampal synaptic function

    Directory of Open Access Journals (Sweden)

    Sullivan Patrick M

    2009-05-01

    Full Text Available Abstract The lipoprotein receptor system in the hippocampus is intimately involved in the modulation of synaptic transmission and plasticity. The association of specific apoE isoform expression with human neurodegenerative disorders has focused attention on the role of these apoE isoforms in lipoprotein receptor-dependent synaptic modulation. In the present study, we used the apoE2, apoE3 and apoE4 targeted replacement (TR mice along with recombinant human apoE isoforms to determine the role of apoE isoforms in hippocampus area CA1 synaptic function. While synaptic transmission is unaffected by apoE isoform, long-term potentiation (LTP is significantly enhanced in apoE4 TR mice versus apoE2 TR mice. ApoE isoform-dependent differences in LTP induction require NMDA-receptor function, and apoE isoform expression alters activation of both ERK and JNK signal transduction. Acute application of specific apoE isoforms also alters LTP induction while decreasing NMDA-receptor mediated field potentials. Furthermore, acute apoE isoform application does not have the same effects on ERK and JNK activation. These findings demonstrate specific, isoform-dependent effects of human apoE isoforms on adult hippocampus synaptic plasticity and highlight mechanistic differences between chronic apoE isoform expression and acute apoE isoform exposure.

  1. &apos;&apos;Black Bone&apos;&apos; MRI: a potential alternative to CT with three-dimensional reconstruction of the craniofacial skeleton in the diagnosis of craniosynostosis

    Energy Technology Data Exchange (ETDEWEB)

    Eley, Karen A. [University of Oxford, John Radcliffe Hospital, Nuffield Department of Surgical Sciences, Oxford (United Kingdom); University of Cambridge, Addenbrookes Hospital, Department of Radiology, Cambridge (United Kingdom); Watt-Smith, Stephen R. [University of Oxford, John Radcliffe Hospital, Nuffield Department of Surgical Sciences, Oxford (United Kingdom); University College London, Eastman Dental Institute, London (United Kingdom); Sheerin, Fintan [University of Oxford, John Radcliffe Hospital, Nuffield Department of Surgical Sciences, Oxford (United Kingdom); Oxford University Hospitals NHS Trust, Oxford (United Kingdom); Golding, Stephen J. [University of Oxford, John Radcliffe Hospital, Nuffield Department of Surgical Sciences, Oxford (United Kingdom)

    2014-10-15

    To determine the potential of novel gradient echo parameters, &apos;&apos;Black Bone&apos;&apos; MRI as an alternative to CT in the identification of normal and prematurely fused cranial sutures both in 2D and 3D imaging. Thirteen children with a clinical diagnosis of craniosynostosis underwent &apos;&apos;Black Bone&apos;&apos; MRI in addition to routine cranial CT. &apos;&apos;Black Bone&apos;&apos; datasets were compared to CT and clinical findings. &apos;&apos;Black Bone&apos;&apos; imaging was subsequently used to develop 3D reformats of the craniofacial skeleton to enhance further visualisation of the cranial sutures. Patent cranial sutures were consistently identified on &apos;&apos;Black Bone&apos;&apos; MRI as areas of increased signal intensity. In children with craniosynostosis the affected suture was absent, whilst the remaining patent sutures could be visualised, consistent with CT and clinical findings. Segmentation of the &apos;&apos;Black Bone&apos;&apos; MRI datasets was successful with both threshold and volume rendering techniques. The cranial sutures, where patent, could be visualised throughout their path. Patent cranial sutures appear as areas of increased signal intensity on &apos;&apos;Black Bone&apos;&apos; MRI distinct from the cranial bone, demonstrating considerable clinical potential as a non-ionising alternative to CT in the diagnosis of craniosynostosis. (orig.)

  2. Response of &apos;Nagpur&apos; mandarin, &apos;Mosambi&apos; sweet orange and &apos;Kagzi&apos; acid lime to gamma radiation

    Energy Technology Data Exchange (ETDEWEB)

    Ladaniya, M.S. E-mail: mslngp@nagpur.dot.net.in; Singh, Shyam; Wadhawan, A.K

    2003-07-01

    The effects of irradiation dose and refrigerated storage conditions on &apos;Nagpur&apos; mandarin (Citrus reticulata Blanco), &apos;Mosambi&apos; sweet orange (Citrus sinensis Osbeck) and &apos;Kagzi&apos; acid lime (Citrus aurantifolia Swingle) were investigated. Mature fruits of these three species were treated with 0, 0.25, 0.5, 1 and 1.5 kGy radiation. &apos;Nagpur&apos; mandarin and &apos;Mosambi&apos; sweet oranges were stored at 6-7 deg. C and 90-95% r.h. for 75 and 90 days, respectively, while &apos;Kagzi&apos; acid limes were stored at 8{+-}1 deg. C and 90-95% r.h. for 90 days. Physico-chemical parameters, sensory attributes and respiration rate were measured besides losses and disorders. In &apos;Nagpur&apos; mandarin, radiation dose upto 1.5 kGy did not cause any rind disorder. Radiation treatments did not reduce the extent of decay. Penicillium rot was delayed in fruit treated with 1.5 kGy, while it appeared early in 0 kGy. Irradiation doses were ineffective to control rots due to Botryodiplodia theobromae and Alternaria citri. Doses upto 1.5 kGy did not cause any significant effect on fruit firmness and juice content; however, total soluble solids increased, while titratable acidity and vitamin &apos;C&apos; content decreased. Texture and flavour scores as recorded after a week, were not affected by irradiation except in 1.5 kGy. In &apos;Mosambi&apos; sweet orange, radiation treatments caused peel disorder in the form of brown sunken areas after 90 days and reduced fruit firmness, acidity and vitamin C content. The TSS content was higher in treated fruit. Flavour and texture were not affected by the doses of irradiation used. In treated acid limes (mature yellow), weight loss and decay were higher than untreated fruit (0 kGy) although difference was non-significant. Juice, TSS, titratable acidity and vitamin C contents were significantly less in treated fruit than in 0 kGy. Texture and flavour scores were also less in treated fruit than in 0 kGy. The

  3. Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis.

    Science.gov (United States)

    Ramos, Pedro; Guy, Ella; Chen, Nan; Proenca, Catia C; Gardenghi, Sara; Casu, Carla; Follenzi, Antonia; Van Rooijen, Nico; Grady, Robert W; de Sousa, Maria; Rivella, Stefano

    2011-01-27

    In hereditary hemochromatosis, mutations in HFE lead to iron overload through abnormally low levels of hepcidin. In addition, HFE potentially modulates cellular iron uptake by interacting with transferrin receptor, a crucial protein during erythropoiesis. However, the role of HFE in this process was never explored. We hypothesize that HFE modulates erythropoiesis by affecting dietary iron absorption and erythroid iron intake. To investigate this, we used Hfe-KO mice in conditions of altered dietary iron and erythropoiesis. We show that Hfe-KO mice can overcome phlebotomy-induced anemia more rapidly than wild-type mice (even when iron loaded). Second, we evaluated mice combining the hemochromatosis and β-thalassemia phenotypes. Our results suggest that lack of Hfe is advantageous in conditions of increased erythropoietic activity because of augmented iron mobilization driven by deficient hepcidin response. Lastly, we demonstrate that Hfe is expressed in erythroid cells and impairs iron uptake, whereas its absence exclusively from the hematopoietic compartment is sufficient to accelerate recovery from phlebotomy. In summary, we demonstrate that Hfe influences erythropoiesis by 2 distinct mechanisms: limiting hepcidin expression under conditions of simultaneous iron overload and stress erythropoiesis, and impairing transferrin-bound iron uptake by erythroid cells. Moreover, our results provide novel suggestions to improve the treatment of hemochromatosis.

  4. Both chronic treatments by epothilone D and fluoxetine increase the short-term memory and differentially alter the mood status of STOP/MAP6 KO mice.

    Science.gov (United States)

    Fournet, Vincent; de Lavilléon, Gaetan; Schweitzer, Annie; Giros, Bruno; Andrieux, Annie; Martres, Marie-Pascale

    2012-12-01

    Recent evidence underlines the crucial role of neuronal cytoskeleton in the pathophysiology of psychiatric diseases. In this line, the deletion of STOP/MAP6 (Stable Tubule Only Polypeptide), a microtubule-stabilizing protein, triggers various neurotransmission and behavioral defects, suggesting that STOP knockout (KO) mice could be a relevant experimental model for schizoaffective symptoms. To establish the predictive validity of such a mouse line, in which the brain serotonergic tone is dramatically imbalanced, the effects of a chronic fluoxetine treatment on the mood status of STOP KO mice were characterized. Moreover, we determined the impact, on mood, of a chronic treatment by epothilone D, a taxol-like microtubule-stabilizing compound that has previously been shown to improve the synaptic plasticity deficits of STOP KO mice. We demonstrated that chronic fluoxetine was either antidepressive and anxiolytic, or pro-depressive and anxiogenic, depending on the paradigm used to test treated mutant mice. Furthermore, control-treated STOP KO mice exhibited paradoxical behaviors, compared with their clear-cut basal mood status. Paradoxical fluoxetine effects and control-treated STOP KO behaviors could be because of their hyper-reactivity to acute and chronic stress. Interestingly, both epothilone D and fluoxetine chronic treatments improved the short-term memory of STOP KO mice. Such treatments did not affect the serotonin and norepinephrine transporter densities in cerebral areas of mice. Altogether, these data demonstrated that STOP KO mice could represent a useful model to study the relationship between cytoskeleton, mood, and stress, and to test innovative mood treatments, such as microtubule-stabilizing compounds.

  5. [Male contraception].

    Science.gov (United States)

    Demoulin, A

    1984-04-01

    Among the reasons why male hormonal contraception has lagged behind female methods are the necessity of preserving virility, the fact that spermatogenesis is a continuous process, the need to control secondary effects and toxicity, and the requirement that modes of administration be acceptable to both partners. Among currently available reversible mehtods, withdrawal is undoubtedly the most ancient. It is still widespread but cannot be recommended because of its limited effectiveness. The condom is used by about 10% of couples worldwide as a principal or temporary method, but its inter-ference with sensation has limited its acceptance. Condoms are nevertheless highly effective when used with a spermicide. Various androgens are currently under investigation. High doses of testosterone can induce azoospermia without affecting libido but their side effects may be serious. The use of combinations of steroids permits doses to be reduced and offers promise for the future. The combination of oral medroxyprogesterone acetate and percutaneous testosterone is one of the better approaches; the combination is effective and nontoxic but has the disadvantage of percutaneous administration. Gossypol, a pigment extracted from the cotton plant, has been used as a contraceptive in China with a reported efficacy of 99.89%, recovery of fertility within 3 months, and no effect on future fertility. However, its toxicity appears to be significant in the animal and its reversibility is uncertain. A search is on for analogs which would preserve the contraceptive effects while eliminating toxic effects. Several gonadotropin releasing hormone (GnRH) analogs under investigation for their interference with spermatogenesis have given promising results. Several chemicals tested for contraceptive effects have had unacceptably high toxicity. Chinese investigators have reported good results with various physical methods of interfering with sperm production, but their reversibility and innocuity

  6. US studies of the pediatric thymus; Valutazione ecografica del timo nell&apos;eta&apos; pediatrica

    Energy Technology Data Exchange (ETDEWEB)

    Tamasi, S.; Rossis, E.; Carbone, M.; Amodio, F.; Mattace Raso, M.; Brunese, L.; Ciccarelli, R.; Vallone, G. [Naples Univ. Federico II, Naples (Italy). Dipt. di Scienze Biomorfologiche e Funzionali, Servizio di Radiologia

    2000-05-01

    The thymus is a linphoepithelial organ located mostly in the anterior mediastinum and, for a smaller part, in the neck. The gland is particularly developed in the fetus and in children, while it shrinks in young adults following an involution process. It has been investigated the US appearance of the thymus in normal pediatric subjects to gather information for use in pediatric patients with suspected thymus conditions, using a safe, irradiation-free, technique. It has performed a US examination of the anterior mediastinum and the neck in 30 children (14 males and 16 females) ranging in age 6 months to 11 years. It was used a Sonora Logic 700 MD General Electric&apos;s unit with 7.5-13 MHz linear probes and acquired transverse and longitudinal scans on the chest wall and the neck, integrated with intercostal scans. The thymus had the same echogenicity as the liver parenchyma in 22 children (73.3%), lower echogenicity in 2 (6.6%, age range 6-12 months) and higher echogenicity with heterogenous structure in 6 children (20%, age range 8-11 years). The gland was in central and symmetric localization in 20 children (66.6%) while it exhibited a slight deviation leftwards in 7 (23.3%) nd rightwards in 3 children (10%). It was considered as normal the following values: in the right lobe 1.4 cm for the AP diameter and 2.5 cm for the longitudinal one; in the left lobe, 1.4 cm for the AP diameter and 2.9 cm for the longitudinal one. Radiological studies of the thymus are really difficult to perform because the gland is extremely variable in size, extension and page. The thymus has the same echogenicity as the liver parenchyma and lower echogenicity than the thyroid parenchyma. It has believed that US is an effective technique for studying the thymus in all its involution stages and that provides similar information to CT and MRI. Also, US does not use radiations and needs no sedation, which improves safety for young patients. [Italian] Il timo localizzato prevalentemente nel

  7. Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis.

    Science.gov (United States)

    Zhu, Li; Zhong, Minghao; Elder, Gregory A; Sano, Mary; Holtzman, David M; Gandy, Sam; Cardozo, Christopher; Haroutunian, Vahram; Robakis, Nikolaos K; Cai, Dongming

    2015-09-22

    The apolipoprotein E4 (ApoE4) allele is the strongest genetic risk factor for developing sporadic Alzheimer's disease (AD). However, the mechanisms underlying the pathogenic nature of ApoE4 are not well understood. In this study, we have found that ApoE proteins are critical determinants of brain phospholipid homeostasis and that the ApoE4 isoform is dysfunctional in this process. We have found that the levels of phosphoinositol biphosphate (PIP2) are reduced in postmortem human brain tissues of ApoE4 carriers, in the brains of ApoE4 knock-in (KI) mice, and in primary neurons expressing ApoE4 alleles compared with those levels in ApoE3 counterparts. These changes are secondary to increased expression of a PIP2-degrading enzyme, the phosphoinositol phosphatase synaptojanin 1 (synj1), in ApoE4 carriers. Genetic reduction of synj1 in ApoE4 KI mouse models restores PIP2 levels and, more important, rescues AD-related cognitive deficits in these mice. Further studies indicate that ApoE4 behaves similar to ApoE null conditions, which fails to degrade synj1 mRNA efficiently, unlike ApoE3 does. These data suggest a loss of function of ApoE4 genotype. Together, our data uncover a previously unidentified mechanism that links ApoE4-induced phospholipid changes to the pathogenic nature of ApoE4 in AD.

  8. OBJECTIVE BAYESIAN ANALYSIS OF &apos;'ON/OFF'&apos; MEASUREMENTS

    Energy Technology Data Exchange (ETDEWEB)

    Casadei, Diego, E-mail: diego.casadei@fhnw.ch [Visiting Scientist, Department of Physics and Astronomy, UCL, Gower Street, London WC1E 6BT (United Kingdom)

    2015-01-01

    In high-energy astrophysics, it is common practice to account for the background overlaid with counts from the source of interest with the help of auxiliary measurements carried out by pointing off-source. In this &apos;'on/off'&apos; measurement, one knows the number of photons detected while pointing toward the source, the number of photons collected while pointing away from the source, and how to estimate the background counts in the source region from the flux observed in the auxiliary measurements. For very faint sources, the number of photons detected is so low that the approximations that hold asymptotically are not valid. On the other hand, an analytical solution exists for the Bayesian statistical inference, which is valid at low and high counts. Here we illustrate the objective Bayesian solution based on the reference posterior and compare the result with the approach very recently proposed by Knoetig, and discuss its most delicate points. In addition, we propose to compute the significance of the excess with respect to the background-only expectation with a method that is able to account for any uncertainty on the background and is valid for any photon count. This method is compared to the widely used significance formula by Li and Ma, which is based on asymptotic properties.

  9. Formation and characterisation of solution processed &apos;'pseudo-bilayer'&apos; organic solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Heinemann, Marc Daniel; Ananthanarayanan, Krishnamoorthy; Thummalakunta, L.N.S.A.; Yong, Chian Haw; Luther, Joachim [Singapore National Univ. (SG). Solar Energy Research Inst. of Singapore (SERIS)

    2011-07-01

    The current state of the art solution processed organic photovoltaic (OPV) cells are based on the bulk heterojunction (BHJ) architecture, consisting of an active layer, in which the donor and the acceptor material are dissolved in a common solvent. In this report, we show that by sequential processing of the active components and by subsequent annealing a &apos;'pseudo-bilayer'&apos; can be formed which results in an enhanced nanomorphology for efficient charge generation and extraction. The enhanced nanomorphology arises from the inter-diffusion of the PCBM nanoparticles into a layer of pre-organised polymer P3HT instead of a phase separation that happens at the time of spin-coating and annealing in the case of conventional BHJ devices. To get a further insight into the inter-diffusion process, TOF-SIMS depth profiling and XPS measurements were carried out for different thermal annealing treatments of these pseudo-bilayer devices, which show full inter-diffusion after only seconds of annealing at 140 C. The optimised photovoltaic devices that were fabricated showed an efficiency of 4.1%. (orig.)

  10. &apos;&apos;1/f noise&apos;&apos; in music: Music from 1/f noise

    Energy Technology Data Exchange (ETDEWEB)

    Voss, R.F.; Clarke, J.

    1978-01-01

    The spectral density of fluctuations in the audio power of many musical selections and of English speech varies approximately as 1/f (f is the frequency) down to a frequency of 5 x 10/sup -4/ Hz. This result implies that the audio-power fluctuations are correlated over all times in the same manner as &apos;&apos;1/f noise&apos;&apos; in electronic components. The frequency fluctuations of music also have a 1/f spectral density at frequencies down to the inverse of the length of the piece of music. The frequency fluctuations of English speech have a quite different behavior, with a single characteristic time of about 0.1 s, the average length of a syllable. The observations on music suggest that 1/f noise is a good choice for stochastic composition. Compositions in which the frequency and duration of each note were determined by 1/f noise sources sounded pleasing. Those generated by white-noise sources sounded too random, while those generated by 1/f/sup 2/ noise sounded too correlated.

  11. Study and designing of the &apos;'caliprax'&apos; measurement bench; Etude et realisation du banc &apos;'caliprax'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Barriere, J.Ch

    2001-09-01

    Probing the matter in order to check its elementary constituents, that is the goal of the particle physic. In this field, the experiments consist in colliding highly energetic particle beams and observing the new born particles. These observations are based on big particle detectors whose running is dependant on the precise knowledge of their geometry (position of the detection chambers). To achieve this, the detectors are equipped with alignment sensors, which have to be calibrated before. This document describes the study and the making of a calibration bench for the &apos;Praxial&apos; (PRoximity AXIAL) type sensors, and other works related to these sensors. In a first part, we determine and apply a method to set the tools used to fix the sensor stands on the detection chambers. These settings are made with the use of a tridimensional measuring machine. Then, we study the stands themselves. These investigations concern mechanics: positioning quality of the sensors in their stands, bending of the supports due to the tightening. In this part too, the studies are in the field of dimensional metrology. After this, the works are reoriented toward the bench, with the choice of the displacement sensors among two different technologies: optical, with the Rasnik system, and mechanical, with linear probes as LVDT (Linear Variable Differential Transformer). Following the discovery of an ambiguity on the Rasnik system, we go on the tests to understand its behaviour. We introduce the theory of the alignment sensors calibration, which is based on a minimization calculation. The computer programs are explained in a chapter, and in an other, the implementation of the quality assurance procedures. An other part describes the mechanical studies and the problems they cause. Because of a delay onset of the project, we make a model of the bench. This dummy allows us to test every single function of the final bench. With this device, we record manually the first calibration data and

  12. Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models.

    Science.gov (United States)

    Huang, Yadong

    2011-08-01

    ApoE4 (apolipoprotein E4) is the major known genetic risk factor for AD (Alzheimer's disease). In most clinical studies, apoE4 carriers account for 65-80% of all AD cases, highlighting the importance of apoE4 in AD pathogenesis. Emerging data suggest that apoE4, with its multiple cellular origins and multiple structural and biophysical properties, contributes to AD in multiple ways either independently or in combination with other factors, such as Aβ (amyloid β-peptide) and tau. Many apoE mouse models have been established to study the mechanisms underlying the pathogenic actions of apoE4. These include transgenic mice expressing different apoE isoforms in neurons or astrocytes, those expressing neurotoxic apoE4 fragments in neurons and human apoE isoform knock-in mice. Since apoE is expressed in different types of cells, including astrocytes and neurons, and in brains under diverse physiological and/or pathophysiological conditions, these apoE mouse models provide unique tools to study the cellular source-dependent roles of apoE isoforms in neurobiology and in the pathogenesis of AD. They also provide useful tools for discovery and development of drugs targeting apoE4's detrimental effects.

  13. Proceedings of the DGMK-conference &apos;Synthesis gas chemistry&apos;. Authors&apos; manuscripts

    Energy Technology Data Exchange (ETDEWEB)

    Hoenicke, D.; Kohlpaintner, C.; Luecke, B.; Reschetilowski, W. [eds.

    2000-07-01

    The main topics of the DGMK-Conference &apos;&apos;Synthesis Gas Chemistry&apos;&apos; were: production of synthesis gas from several educts, new catalysts, Fischer-Tropsch synthesis, hydroformylation, steam reforming and carbonylation.

  14. Liraglutide protects against nonalcoholic fatty liver disease in ApoE knockout mice with high-fat diet and silenced Acrp30 by increasing AMPK%利拉鲁肽改善非酒精性脂肪性肝病小鼠肝脂肪沉积的机制探讨

    Institute of Scientific and Technical Information of China (English)

    赵昕怡; 张利莉; 索朗曲珍; 杨刚毅; 李伶; 李生兵; 陈文雯

    2014-01-01

    investigate the mechanism ofliraglutide-mediated protection against nonalcoholic fatty liver disease (NAFLD) using aApoE knockout (KO) mouse with high-fat diet (HFD) and Acrp30 knockdown.Methods Fifty-six male ApoE KO mice were divided into the following six modeling and experimental groups:regular chow fed (ApoE KO,n =10),HFD fed (HF,n =10),HFD+Adenovirus (Ad)-small hairpin (sh) Acrp30 (Ad-shAcrp30,n =10),HFD+Ad-shGreen Fluorescent Protein (GFP) (Ad-shGFP,n =6),HFD+Ad-shAcrp30+liraglutide (liraglutide,n =10),and HFD+Ad-shAcrp30+saline (saline,n =10).Weight-matched C57BL/6 mice on the regular chow diet were used as the control group (WT control,n =10).All mice were fed their assigned diet for 16 weeks.The Ad-shGFP or Ad-shAcrp30 was injected by tail vein at the end of 14 and 15 weeks.Mice in the liraglutide group received 1 mg/kg of the drug,twice daily,intraperitoneally for a total of 8 weeks (from the 9th to 16th week).Fasting blood samples were collected for testing levels of fasting plasma glucose (FPG),triglycerides (TGs),total cholesterol (TC),free fatty acid (FFA),alanine aminotransferase (ALT),Acrp30 and insulin.Liver tissue was procured for histological examination.Expression of mRNA was detected by real-time RT-PC and of protein was detected by western blot analysis.Results The Ad-shAcrp30 treated mice had reduced expression of Acrp30 at both the mRNA and protein levels in adipose tissues and plasma,as compared with the AdshGFP treated mice (all P < 0.01).Compared to the WT and ApoE KO groups,the HF group showed higher levels of FPG,FFA,TGs and TC (all P < 0.01); furthermore,the Ad-shAcrp30 treatment compounded these changes.The Ad-shAcrp30 treated group had markedly higher hepatic TC and TGs than the HF group (P < 0.01 andP <0.05).Oil Red O staining showed that there was more lipid droplets in the liver tissue of the Ad-shAcrp30 treated group than in that of the HF group (P < 0.01),and hematoxylin-eosin staining confirmed these results

  15. Absorption-line &apos;'forest'&apos; in quasar spectra, and the structure of the universe

    Energy Technology Data Exchange (ETDEWEB)

    Doroshkevich, A.G.; Muket, J.P.

    1985-05-01

    The &apos;'forest'&apos; of absorption lines observed in the spectrum of distant quasars is interpreted in light of the adiabatic (pancake) theory for the origin and evolution of structure in the universe. The hidden mass might reside in neutrino-like particles (perhaps unstable) having a rest mass of about 60--100 eV. Opportunities for testing the hypothesis observationally are discussed.

  16. Magnetic fluctuations can contribute to plasma transport, &apos;&apos;self-consistency constraints&apos;&apos; notwithstanding

    Energy Technology Data Exchange (ETDEWEB)

    Krommes, J.A.; Kim, Chang-Bae

    1987-09-01

    The recent conclusion that in a turbulent, collisionless plasma &apos;&apos;magnetic transport including quasilinear magnetic flutter transport ... does not contribute to the relaxation of (f), and thus is not responsible for electron energy or momentum transport&apos;&apos; is shown to be incorrect for a variety of situations of physical interest, including saturation by quasilinear plateau formation, induced scattering, and, most importantly, conventional mode coupling. The well-established theory of the mean infinitesimal response function and the spectral balance equation provides a unifying framework for understanding the above conclusion. In particular, the cancellations which lead to their conclusion are special cases of well-known relationships between the response function, particle propagator, and dielectric function. A more general, concise, and manifestly gauge-invariant algebraic derivation of the cancellations is given. Though the cancellations occur in a certain limit, these conclusions do not follow in general: The picture of steady-state turbulence as consisting of small-scale &apos;'incoherent'&apos; ballistic &apos;'clumps'&apos; shielded by long-wavelength &apos;'coherent'&apos; dielectric response is physically misleading and mathematically incomplete, as it ignores or mistreates the often dominant process of renormalized n-wave coupling. Thus, when ion nonlinearities are considered, formulas for the magnetic contribution to transport emerge which are quite similar to the quasilinear one. Furthermore, limits are possible in which all or part of the noise can be negligible, yet in which the total fluctuation spectrum remains finite. 56 refs.

  17. In vivo imaging of &apos;'neuroinflammation'&apos;. Principles and applications; In-vivo-Darstellung &apos;'neuroinflammatorischer'&apos; Veraenderungen mit [{sup 11}C] PK11195-PET. Grundlagen und Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Gerhard, A.; Banati, R.B. [MRC Clinical Sciences Centre and Div. of Neuroscience, Faculty of Medicine, Imperial Coll., London (United Kingdom)

    2002-09-01

    Microglia are the brains&apos; resident immunocompetent cells that can be activated by acute as well as chronic pathological stimuli. When activated they express the peripheral benzodiazepine binding site to which the isoquinolin PK11195 binds with high specificity. Labelled with [{sup 11}C], the R-enatiomer [{sup 11}C] PK1195 has been used for positron emission tomography (PET) studies to demonstrate neuroinflammatory changes in vivo. [{sup 11}C](R) PK11195-PET has been successfully used to show in vivo microglial activation in ischemic (stroke), inflammatory (multiple sclerosis) and degenerative (Alzheimer&apos;s and Parkinson&apos;s disease). Longitudinal studies are in progress to help to clarify the relationship between localisation and extent of microglial activation and the clinical presentations in these disorders. This will help to determine the role of [{sup 11}C](R) PK11195 PET as a diagnostic tool and a surrogate marker of &apos;'neuroinflammation'&apos; in therapeutic trials. (orig.) [German] Mikroglia sind residente immunkompetente Zellen des Gehirns, die durch akute, aber auch langsam voranschreitende, chronische Schaedigungprozesse aktiviert werden. Im aktivierten Zustand exprimieren sie den peripheren Benzodiazepinrezeptor, an den das Isoquinolin PK11195 spezifisch bindet. Radioaktiv markiert kann das R-Enantiomer [{sup 11}C] PK11195 als Ligand in der Positronenemissionstomographie (PET) genutzt werden und ermoeglicht so die In-vivo-Darstellung aktiver &apos;'neuroinflammatorischer'&apos;, d.h. die Mikroglia aktivierender, Veraenderungen. Mit der [{sup 11}C](R) PK11195-PET konnte bisher In-vivo-Mikrogliaaktivierung bei ischaemischen (Schlaganfall), entzuendlichen (multiple Sklerose) und degenerativen (Morbus Alzheimer- und Parkinson-Erkrankung) demonstriert werden. Laufende longitudinale Studien werden dazu beitragen, die Beziehung zwischen Lokalisation und Ausmass der Mikrogliaaktivierung und klinischer Krankheitsauspraegung

  18. Comparative study of dermal components and plasma TGF-β1 levels in Slc39a13/Zip13-KO mice

    Science.gov (United States)

    HIROSE, Takuya; OGURA, Takayuki; TANAKA, Keisuke; MINAGUCHI, Jun; YAMAUCHI, Takeshi; FUKADA, Toshiyuki; KOYAMA, Yoh-ichi; TAKEHANA, Kazushige

    2015-01-01

    Ehlers-Danlos syndrome (EDS) is a group of disorders caused by abnormalities that are identified in the extracellular matrix. Transforming growth factor-β1 (TGF-β1) plays a crucial role in formation of the extracellular matrix. It has been reported that the loss of function of zinc transporter ZRT/IRT-like protein 13 (ZIP13) causes the spondylocheiro dysplastic form of EDS (SCD-EDS: OMIM 612350), in which dysregulation of the TGF-β1 signaling pathway is observed, although the relationship between the dermis abnormalities and peripheral TGF-β1 level has been unclear. We investigated the characteristics of the dermis of the Zip13-knockout (KO) mouse, an animal model for SCD-EDS. Both the ratio of dermatan sulfate (DS) in glycosaminoglycan (GAG) components and the amount of collagen were decreased, and there were very few collagen fibrils with diameters of more than 150 nm in Zip13-KO mice dermis. We also found that the TGF-β1 level was significantly higher in Zip13-KO mice serum. These results suggest that collagen synthesis and collagen fibril fusion might be impaired in Zip13-KO mice and that the possible decrease of decorin level by reduction of the DS ratio probably caused an increase of free TGF-β1 in Zip13-KO mice. In conclusion, skin fragility due to defective ZIP13 protein may be attributable to impaired extracellular matrix synthesis accompanied by abnormal peripheral TGF-β homeostasis. PMID:26050750

  19. Z dziejów drukarstwa i handlu książką w Kołobrzegu w drugiej połowie XVII wieku

    Directory of Open Access Journals (Sweden)

    Radosław Gaziński

    2009-01-01

    Full Text Available W Archiwum Krajowym w Greifswaldzie w zespole archiwalnym Staatskanzelei zachowały się trzy jednostki archiwalne dotyczące drukarstwa i handlu książką w Kołobrzegu w drugiej połowie XVII wieku. Są to materiały o charakterze instytucjonalnym pokazujące problemy drukarstwa i handlu książką od strony brandenburskiej administracji prowincjonalnej. Drukarnię założono w Kołobrzegu za zgodą elektora Fryderyka Wilhelma w maju 1653 roku, a pierwszym drukarzem został Henryk Heissen. Po nim do końca XVII wieku drukarnię prowadzili: Jakub Kusen, Berger Campen i Johann Mikołaj Ernst. Drukarze w Kołobrzegu nie tylko drukowali książki, ale również sprzedawali je na terenie miasta. Obok nich w omawianym okresie działali tu także profesjonalni handlarze książkami: Jeremiasz Amphras, Jeremiasz Mamfass, Jakub Henning, Johan Danhardt i Jeremiasz Schrey. W drugiej połowie XVII wieku Kołobrzeg był, jak na warunki pomorskie, znaczącym centrum drukarstwa i handlu książką. Znaczenie to pomniejszyło przeniesienie stolicy prowincji do Stargardu (1668 rok.

  20. &apos;&apos;Whither Deterrence?&apos;&apos; A Brief Synopsis May, 2002

    Energy Technology Data Exchange (ETDEWEB)

    Poppe, C; Vergino, E; Barker, R; Brown, P; Gilmartin, T J; Nach, M; Sloss, L

    2002-05-29

    To most audiences, deterrence has been interconnected with nuclear weapons whose purpose had been to deter a Soviet attack. But, the Soviet Union has been gone for almost a decade. President George W. Bush has stated that Russia is not an enemy of the US and the numbers of nuclear weapons can be dramatically reduced. It is important to note that deterrence has always transcended nuclear weapons. The US&apos; first line of deterrence has been its formidable conventional warfare capability, designed to prevent conflict and win wars if necessary. The role of nuclear weapons has been to deter the,use of nuclear weapons and other weapons of mass destruction against U.S. interests during the conduct of conventional warfare and to ensure our ability to inflict massive destruction on any who would use nuclear weapons, or other weapons of mass destruction, against us. With regard to the Soviet Union, the threat of the use of nuclear weapons was a critical component of our deterrent to prevent massive Soviet conventional attack against our allies in Europe. However, the events of September 11, 2001 make clear that we have not convinced all who seek to harm us that we will be able to respond in a manner to make them wish they had not even tried. The September 11 attacks, as well as other past conflicts, do not mean that deterrence has failed-it remains effective against the threats for which it was designed. We have known there are other threats for which we did not have a credible deterrent. The challenge is to sustain deterrence against the classic threats as they evolve in technical sophistication while remaining alert to the need to evaluate continuously our ability to deter previously unforeseen challenges. How then should we be looking at deterrence as we consider fifteen or so years in the future, say to about 2015? What will be the role of nuclear weapons and other instruments of mass destruction in the future? What should the US be doing to prepare for the future? In

  1. &apos;&apos;Whither Deterrence?&apos;&apos; A Brief Synopsis May, 2002

    Energy Technology Data Exchange (ETDEWEB)

    Poppe, C; Vergino, E; Barker, R; Brown, P; Gilmartin, T J; Nach, M; Sloss, L

    2002-05-29

    To most audiences, deterrence has been interconnected with nuclear weapons whose purpose had been to deter a Soviet attack. But, the Soviet Union has been gone for almost a decade. President George W. Bush has stated that Russia is not an enemy of the US and the numbers of nuclear weapons can be dramatically reduced. It is important to note that deterrence has always transcended nuclear weapons. The US&apos; first line of deterrence has been its formidable conventional warfare capability, designed to prevent conflict and win wars if necessary. The role of nuclear weapons has been to deter the,use of nuclear weapons and other weapons of mass destruction against U.S. interests during the conduct of conventional warfare and to ensure our ability to inflict massive destruction on any who would use nuclear weapons, or other weapons of mass destruction, against us. With regard to the Soviet Union, the threat of the use of nuclear weapons was a critical component of our deterrent to prevent massive Soviet conventional attack against our allies in Europe. However, the events of September 11, 2001 make clear that we have not convinced all who seek to harm us that we will be able to respond in a manner to make them wish they had not even tried. The September 11 attacks, as well as other past conflicts, do not mean that deterrence has failed-it remains effective against the threats for which it was designed. We have known there are other threats for which we did not have a credible deterrent. The challenge is to sustain deterrence against the classic threats as they evolve in technical sophistication while remaining alert to the need to evaluate continuously our ability to deter previously unforeseen challenges. How then should we be looking at deterrence as we consider fifteen or so years in the future, say to about 2015? What will be the role of nuclear weapons and other instruments of mass destruction in the future? What should the US be doing to prepare for the future? In

  2. &apos;Crazy-Paving&apos; Patterns on High-Resolution CT Scans in Patients with Pulmonary Complications after Hematopoietic Stem Cell Transplantation

    Energy Technology Data Exchange (ETDEWEB)

    Marchiori, Edson; Escuissato, Dante L.; Gasparetto, Taisa Davaus; Considera, Daniela Peixoto [Federal University, Sao Paulo (Brazil); Franquet, Tomas [Hospital de Sant Pau, Universitat Autonoma de Barcelona, Barcelona (Spain)

    2009-02-15

    To describe the pulmonary complications following hematopoietic stem cell transplantation (HSCT) that can present with a &apos;crazy-paving&apos; pattern in high-resolution CT scans. Retrospective review of medical records from 2,537 patients who underwent HSCT. The &apos;crazy-paving&apos; pattern consists of interlobular and intralobular septal thickening superimposed on an area of ground-glass attenuation on high-resolution CT scans. The CT scans were retrospectively reviewed by two radiologists, who reached final decisions by consensus. We identified 10 cases (2.02%), seven male and three female, with pulmonary complications following HSCT that presented with the &apos;crazy-paving&apos; pattern. Seven (70%) patients had infectious pneumonia (adenovirus, herpes simplex, influenza virus, cytomegalovirus, respiratory syncytial virus, and toxoplasmosis), and three patients presented with non-infectious complications (idiopathic pneumonia syndrome and acute pulmonary edema). The &apos;crazy-paving&apos; pattern was bilateral in all cases, with diffuse distribution in nine patients (90%), predominantly in the middle and inferior lung regions in seven patients (70%), and involving the anterior and posterior regions of the lungs in nine patients (90%). The &apos;crazy-paving&apos; pattern is rare in HSCT recipients with pulmonary complications and is associated with infectious complications more commonly than non-infectious conditions.

  3. Qualification Program of Korea Heat Load Test Facility KoHLT-EB for ITER Plasma Facing Components

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Suk-Kwon; Park, Seoung Dae; Jin, Hyung Gon; Lee, Eo Hwak; Yoon, Jae-Sung; Lee, Dong Won [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Cho, Seungyon [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    The qualification tests were performed to evaluate the high heat flux test facility for the PFCs and fusion reactor materials. For the thermal fatigue test, two types of tungsten mock-ups were fabricated. The cooling performance was tested under the similar operation condition of ITER and fusion reactor. After the completion of the preliminary mockup test and facility qualification, the high heat flux test facility will assess the performance test for the various plasma facing components in fusion reactor materials. Preliminary thermo-hydraulic and performance tests were conducted using various test mockups for the plasma facing components in the high heat flux test facilities of the world. The previous heat flux tests were performed by using the graphite heater facilities in Korea. Several facilities which equipped with an electron beam as the uniform heat source were fabricated for the tokamak PFCs in the EU, Russia and US. These heat flux test facilities are utilized for a cyclic heat flux test of the PFCs. Each facility working for their own purpose in EU FZJ, US SNL, and Russia Efremov institute. For this purpose, KoHLTEB was constructed and this facility will be used for ITER TBM performance test with the small-scale and large-scale mockups, and prototype. Also, it has been used for other fusion application for developing plasma facing component (PFC) for ITER FW, tungsten divertor, and heat transfer experiment and so on under the domestic R and D program. Korea heat load test facility by using electron beam KoHLT-EB was constructed for the high heat flux test to verify the plasma facing components, including ITER TBM first wall.

  4. Coastal vulnerability to typhoon inundation in the Bay of Bangkok, Thailand? Evidence from carbonate boulder deposits on Ko Larn island

    Science.gov (United States)

    Terry, James P.; Jankaew, Kruawun; Dunne, Kieran

    2015-11-01

    At the head of the Gulf of Thailand, the subsiding Chao Phraya delta and adjacent low-lying coastlines surrounding the Bay of Bangkok are at risk of coastal flooding. Although a significant marine inundation event has not been experienced in historical times, this work identifies coastal depositional evidence for high-energy waves in the past. On Ko Larn island in eastern Bay of Bangkok, numerous coastal carbonate boulders (CCBs) were discovered at elevations up to 4+ m above sea level, the largest weighing over 1.3 tonnes. For the majority of CCBs, their karstified appearance bears testimony to long periods of immobility since original deposition, whilst their geomorphic settings on coastal slopes of coarse blocky talus is helpful in recognising lifting (saltation) as the probable mode of wave transport. In the absence of local tsunamigenic potential, these CCBs are considered to be prehistoric typhoon deposits, presumably sourced from fringing coral reefs by high-energy wave action. Application of existing hydrodynamic flow transport equations reveals that 4.7 m/s and 7.1 m/s are the minimum flow velocities required to transport 50% and 100% of the measured CCBs, respectively. Such values are consistent with cyclone-impacted coastlines studied elsewhere in the tropical Asia-Pacific region. Overall, the evidence of elevated carbonate boulder deposits on Ko Larn implies that typhoons before the modern record may have entered the Bay of Bangkok. The recurrence of a similar event in future would have the potential to cause damaging marine inundation on surrounding low-lying coastlines.

  5. VEGF Mediates ApoE4-Induced Neovascularization and Synaptic Pathology in the Choroid and Retina.

    Science.gov (United States)

    Antes, Ran; Salomon-Zimri, Shiran; Beck, Susanne C; Garcia Garrido, Marina; Livnat, Tami; Maharshak, Idit; Kadar, Tamar; Seeliger, Mathias; Weinberger, Dov; Michaelson, Daniel M

    2015-01-01

    Apolipoprotein E4 (apoE4), the most prevalent genetic risk factor for Alzheimer's disease (AD), is associated with neuronal and vascular impairments. Recent findings suggest that retina of apoE4 mice have synaptic and functional impairments. We presently investigated the effects of apoE4 on retinal and choroidal vasculature and the possible role of VEGF in these effects. There were no histological differences between the retinal and choroidal vasculatures of naïve apoE3 and apoE4 mice. In contrast, laserdriven choroidal injury induced higher levels of choroidal neovascularization (CNV) in apoE4 than in apoE3 mice. These effects were associated with an inflammatory response and with activation of the Muller cells and asrocytic markers gluthatione synthetase and GFAP, all of which were more pronounced in the apoE4 mice. CNV also induced a transient increase in the levels of the synaptic markers synaptophysin and PSD95 which were however similar in the apoE4 and apoE3 naive mice. Retinal and choroidal VEGF and apoE levels were lower in naïve apoE4 than in corresponding apoE3 mice. In contrast, VEGF and apoE levels rose more pronouncedly following laser injury in the apoE4 than in apoE3 mice. Taken together, these findings suggest that the apoE4-induced retinal impairments, under basal conditions, may be related to reduced VEGF levels in the eyes of these mice. The hyper-neovascularization in the apoE4 mice might be driven by increased inflammation and the associated surge in VEGF following injury. Retinal and choroidal VEGF and apoE levels were lower in naïve apoE4 than in corresponding apoE3 mice. In contrast, VEGF and apoE levels rose more pronouncedly following laser injury in the apoE4 than in apoE3 mice. Taken together, these findings suggest that the apoE4-induced retinal impairments, under basal conditions, may be related to reduced VEGF levels in the eyes of these mice. The hyper-neovascularization in the apoE4 mice might be driven by increased inflammation

  6. Report of working committee 3 &apos;&apos;liquefied gases&apos;&apos;; Rapport du comite de travail 3 &apos;&apos;gaz liquefies&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Baudino, M.

    2000-07-01

    Working Committee 3&apos;s report concerns the evolution of the liquefied gas industry: both liquefied natural gas (LNG) and liquefied petroleum gases (LPG). Given the current state of the LNG market the Committee decided to concentrate on this area in particular. A number of aspects have been identified which the Committee has been looking at, while others have been given to Study Groups set up specifically for the purpose. The first aspects regard: - the development of LNG and LPG, new installations, future chains and relevant statistical data; - the role of LNG and LPG in starting up a gas industry; - operating and technological improvements in the LNG industry; - energy savings, cold utilization and reduction of CO{sub 2} emissions. The Study Groups which were set up dealt with the following subjects: Technological and Economical Developments for cost Reduction of LNG/LPG Facilities. Small Scale LNG Projects and Modular Systems. LNG/LPG Peak Shaving and Satellite Plants. LNG versus Pipeline Infrastructure. (author)

  7. &apos;&apos;Atomic Optics&apos;&apos;: Nonimaging Optics on the Nanoscale

    Energy Technology Data Exchange (ETDEWEB)

    Roland Winston Joseph O' Gallagher

    2005-01-15

    This is the final report for a one year close out extension of our basic research program that was established at the University of Chicago more than sixteen years ago to explore and develop the optical sub-discipline that has come to be known as &apos;&apos;nonimaging optics&apos;&apos;. This program has been extremely fruitful, having both broadened the range of formalism available for workers in this field and led to the discovery of many new families of optical devices. These devices and techniques have applications wherever the efficient transport and transformation of light distributions are important, in particular in illumination, fiber optics, collection and concentration of sunlight, and the detection of faint light signals in physics and astrophysics. Over the past thirty years, Nonimaging Optics (Welford and Winston, 1989) has brought a fresh approach to the analysis of many problems in classical macro-scale optics. Through the application of phase-space concepts, statistical methods, thermodynamic arguments, etc., many previously established performance limits were able to be broken and many technical surprises with exciting practical applications were discovered. The most recent three-year phase of our long-term continuing program ended in late 2002 and emphasized extending our work in geometrical optics and expanding it to include some interesting questions in physical optics as well as in the new field of statistical optics. This report presents a survey of the basic history and concepts of nonimaging optics and reviews highlights and significant accomplishments over the past fifteen years. This is followed by a more detailed summary of recent research directions and accomplishments during the last three years. This most recent phase was marked by the broadening in scope to include a separate project involving a collaboration with an industrial partner, Science Applications International Corporation (SAIC). This effort was proposed and approved in

  8. SHORT GAMMA-RAY BURSTS IN THE &apos;'TIME-REVERSAL'&apos; SCENARIO

    Energy Technology Data Exchange (ETDEWEB)

    Ciolfi, Riccardo [Physics Department, University of Trento, Via Sommarive 14, I-38123 Trento (Italy); Siegel, Daniel M., E-mail: riccardo.ciolfi@unitn.it, E-mail: daniel.siegel@aei.mpg.de [Max Planck Institute for Gravitational Physics (Albert Einstein Institute), Am Mühlenberg 1, D-14476 Potsdam-Golm (Germany)

    2015-01-10

    Short gamma-ray bursts (SGRBs) are among the most luminous explosions in the universe and their origin still remains uncertain. Observational evidence favors the association with binary neutron star or neutron star-black hole (NS-BH) binary mergers. Leading models relate SGRBs to a relativistic jet launched by the BH-torus system resulting from the merger. However, recent observations have revealed a large fraction of SGRB events accompanied by X-ray afterglows with durations ∼10{sup 2}-10{sup 5} s, suggesting continuous energy injection from a long-lived central engine, which is incompatible with the short (≲ 1 s) accretion timescale of a BH-torus system. The formation of a supramassive NS, resisting the collapse on much longer spin-down timescales, can explain these afterglow durations, but leaves serious doubts on whether a relativistic jet can be launched at the merger. Here we present a novel scenario accommodating both aspects, where the SGRB is produced after the collapse of a supramassive NS. Early differential rotation and subsequent spin-down emission generate an optically thick environment around the NS consisting of a photon-pair nebula and an outer shell of baryon-loaded ejecta. While the jet easily drills through this environment, spin-down radiation diffuses outward on much longer timescales and accumulates a delay that allows the SGRB to be observed before (part of) the long-lasting X-ray signal. By analyzing diffusion timescales for a wide range of physical parameters, we find delays that can generally reach ∼10{sup 5} s, compatible with observations. The success of this fundamental test makes this &apos;'time-reversal'&apos; scenario an attractive alternative to current SGRB models.

  9. Volatile oil prices: two propositions from economics and &apos;'Realpolitik'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Wirl, F.

    1988-02-01

    This paper attempts to interpret OPEC&apos;s decision making process by analysing the political-economic behaviour of the Member Countries of the Organization of the Petroleum Exporting Countries. The economic objectives of OPEC members is first discussed under the hypothesis of cooperation versus competition. A loose marketing arrangement among OPEC members is then assumed. Both approaches, pure economics and Real-politik lead to the same conclusion: the likelihood of a volatile price increase.

  10. Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain.

    Science.gov (United States)

    Leishman, Emma; Mackie, Ken; Luquet, Serge; Bradshaw, Heather B

    2016-06-01

    A leading hypothesis of N-acyl ethanolamine (NAE) biosynthesis, including the endogenous cannabinoid anandamide (AEA), is that it depends on hydrolysis of N-acyl-phosphatidylethanolamines (NAPE) by a NAPE-specific phospholipase D (NAPE-PLD). Thus, deletion of NAPE-PLD should attenuate NAE levels. Previous analyses of two different NAPE-PLD knockout (KO) strains produced contradictory data on the importance of NAPE-PLD to AEA biosynthesis. Here, we examine this hypothesis with a strain of NAPE-PLD KO mice whose lipidome is uncharacterized. Using HPLC/MS/MS, over 70 lipids, including the AEA metabolite, N-arachidonoyl glycine (NAGly), the endocannabinoid 2-arachidonyl glycerol (2-AG) and prostaglandins (PGE(2) and PGF(2α)), and over 60 lipoamines were analyzed in 8 brain regions of KO and wild-type (WT) mice. Lipidomics analysis of this third NAPE-PLD KO strain shows a broad range of lipids that were differentially affected by lipid species and brain region. Importantly, all 6 NAEs measured were significantly reduced, though the magnitude of the effect varied by fatty acid saturation length and brain region. 2-AG levels were only impacted in the brainstem, where levels were significantly increased in KO mice. Correspondingly, levels of arachidonic acid were significantly decreased exclusively in brainstem. NAGly levels were significantly increased in 4 brain regions and levels of PGE(2) increased in 6 of 8 brain regions in KO mice. These data indicate that deletion of NAPE-PLD has far broader effects on the lipidome than previously recognized. Therefore, behavioral characteristics of suppressing NAPE-PLD activity may be due to a myriad of effects on lipids and not simply due to reduced AEA biosynthesis.

  11. Promoting and Financing Cultural Tourism in Europe through European Capitals of Culture: A Case Study of Košice, European Capital of Culture 2013

    Directory of Open Access Journals (Sweden)

    Miriam Šebová

    2014-05-01

    Full Text Available The paper highlights the link between the European Capital of Culture (ECoC designation and the development of cultural tourism in Europe. Cultural tourism is the fastest growing segment of tourism in the world and is the desirable objective of new defined cultural policies in European cities. According to the European Commission (2012, it is estimated that cultural tourism accounts for around 40% of all European tourism. In general, the European Commission confirms the significant role of cultural tourism in the development of tourism in Europe and one of the most visible tools of this strategy is the designation of the ECoC. Cultural policy has also become an important tool of urban regeneration and in the rebranding of European cities. The case study of Košice ECoC 2013 presents part of the results from the Košice ECoC evaluation project. The Košice ECoC 2013 project was designed as a community led project which was targeted at increasing the cultural consumption of residents rather than the number of foreign cultural tourists. However, the biggest events such as White night attracted a lot of tourists from the wider region. More than 70 million EUR was dedicated to investments, which have significantly improved the culture infrastructure in Košice. The ECoC designation supported the local cultural buzz and led to new local production of modern culture, art and the creative industries. Other visible effects have already been seen in the advantages gained by the decentralization of the cultural infrastructure and events in the neighbourhoods. The involvement of people outside the city centre has avoided gentrification in the city. From this point of view the project Košice ECoC 2013 has had the prerequisite to sustainable cultural tourism in Košice

  12. Selection of foraging habitat and diet of the Hoopoe Upupa epops in the mosaic-like cultural landscape of Goričko (NE Slovenia)

    OpenAIRE

    Podletnik Mojca; Denac Damijan

    2015-01-01

    In 2012 and 2013, the selection of foraging habitats and the diet of the Hoopoe Upupa epops were studied in the Goričko area, where a significant population decline of the species has been recorded in the past 15 years. Goričko is an area with a well-preserved traditional mosaic-like agricultural landscape very rich in biodiversity which, however, is disappearing. The diet was determined using automatic camera recordings of prey brought to chicks by parents. Mole crickets Gryllotalpa gryllota...

  13. CREATE TRANSGENIC RABBITS BY MICROINJECTING HUMAN apoA-ⅡGENE INTO FERTILIZED EGGS

    Institute of Scientific and Technical Information of China (English)

    Liu Enqi(刘恩岐); Shuji Kitajima; Masatoshi Morimoto

    2004-01-01

    Objective To create transgenic rabbits by microinjecting human apolipoprotein A-Ⅱ (apoA-Ⅱ) gene into one-cell embryos, to study apoA-Ⅱ gene function on plasma lipoprotein metabolism and atherosclerosis. Methods Superovulation and synchronization of estrus were induced in female Japanese White Rabbits by injecting hormone, then mating with male. After collected the fertilized eggs, the human apoA-Ⅱ gene was microinjected into the male pronucleus of eggs. The injected eggs were transferred into recipient female rabbits. Last, extract DNA from the new borns ear and determine whether the newborns were transgenic by polymerase chain reaction (PCR) or Southern blot analysis. Results A total of 822 embryos with microinjection of human apoAⅡ gene were implanted into 28 recipient rabbits. The number of surviving newborns was 37. 3 transgenic positive surviving founders were found with human apoA-Ⅱ.

  14. Extracellular proteolysis of apolipoprotein E (apoE by secreted serine neuronal protease.

    Directory of Open Access Journals (Sweden)

    Irfan Y Tamboli

    Full Text Available Under normal conditions, brain apolipoprotein E (apoE is secreted and lipidated by astrocytes, then taken up by neurons via receptor mediated endocytosis. Free apoE is either degraded in intraneuronal lysosomal compartments or released. Here we identified a novel way by which apoE undergoes proteolysis in the extracellular space via a secreted neuronal protease. We show that apoE is cleaved in neuronal conditioned media by a secreted serine protease. This apoE cleavage was inhibited by PMSF and α1-antichymotrypsin, but not neuroserpin-1 or inhibitors of thrombin and cathepsin G, supporting its identity as a chymotrypsin like protease. In addition, apoE incubation with purified chymotrypsin produced a similar pattern of apoE fragments. Analysis of apoE fragments by mass spectrometry showed cleavages occurring at the C-terminal side of apoE tryptophan residues, further supporting our identification of cleavage by chymotrypsin like protease. Hippocampal neurons were more efficient in mediating this apoE cleavage than cortical neurons. Proteolysis of apoE4 generated higher levels of low molecular weight fragments compared to apoE3. Primary glial cultures released an inhibitor of this proteolytic activity. Together, these studies reveal novel mechanism by which apoE can be regulated and therefore could be useful in designing apoE directed AD therapeutic approaches.

  15. The effect of a high-fat diet on brain plasticity, inflammation and cognition in female ApoE4-knockin and ApoE-knockout mice

    NARCIS (Netherlands)

    C.I.F. Janssen (Carola); D. Jansen (Diane); M.P.C. Mutsaers (Martina); J. Dederen (Jos); B. Geenen (Bram); M. Mulder (Monique); A.J. Kiliaan Kiliaan (Amanda J.)

    2016-01-01

    textabstractApolipoprotein E4 (ApoE4), one of three common isoforms of ApoE, is a major risk factor for late-onset Alzheimer disease (AD). ApoE-deficient mice, as well as mice expressing human ApoE4, display impaired learning and memory functions and signs of neurodegeneration. Moreover, ApoE protec

  16. Locality or non-locality in quantum mechanics: hidden variables without &apos;&apos;spooky action-at-a-distance&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Aharonov, Y. [Texas A and M Univ., College Station, TX (United States); South Carolina Univ., Columbia, SC (United States). Dept. of Physics and Astronomy; Tel Aviv Univ. (Israel). School of Physics and Astronomy; Botero, A. [South Carolina Univ., Columbia, SC (United States). Dept. of Physics and Astronomy; Centro Internacional de Fisica, Ciudad Univ., Bogota (Colombia); Scully, M. [Texas A and M Univ., College Station, TX (United States); Max-Planck-Institut fuer Quantenoptik (MPQ), Garching (Germany)

    2001-02-01

    The folklore notion of the &apos;&apos;Non-Locality of Quantum Mechanics&apos;&apos; is examined from the point of view of hidden-variables theories according to Belinfante&apos;s classification in his Survey of Hidden Variables Theories. It is here shown that in the case of EPR, there exist hidden variables theories that successfully reproduce quantum-mechanical predictions, but which are explicitly local. Since such theories do not fall into Belinfante&apos;s classification, we propose an expanded classification which includes similar theories, which we term as theories of the &apos;'third'&apos; kind. Causal implications of such theories are explored. (orig.)

  17. The &apos;Instrumental&apos; Reality of Phlogiston

    Directory of Open Access Journals (Sweden)

    Mi Gyung Kim

    2008-07-01

    Full Text Available The stability of phlogiston in eighteenth-century French chemistry depended not on its role as a comprehensive theory, but on its operational (instrumental, theoretical, and philosophical (speculative identities that were forged in different contexts, yet were interwoven to designate a single substance. It was as &apos;real&apos; as any other chemical substance to the degree that it was obtained through material operations, occupied a place in the theoretical edifice of the affinity table, and was endowed with a corpuscular ontology. Lavoisier labeled it as an &apos;imaginary&apos; substance because it offered a unique resistance to his vision of the new chemistry based on &apos;metric&apos; measurements and algebraic representations.

  18. NDA National Graduate Programme &apos;nucleargraduates&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Dawson, Carl

    2010-07-01

    The aim of this paper is to outline the NDA National Graduate Programme (nuclear graduates). The NDA has a remit under the Energy Act (2004) &apos;to maintain and develop the skills for decommissioning and nuclear clean-up&apos;. Although current research is now being reviewed, there is significant evidence to suggest that the age profile in the Site Licence Companies is skewed towards older workers and there is likely to be a skill shortage in 3-5 years. As nuclear clean-up is a national issue; skill shortages also become a national issue in a very real sense. In addition, evidence suggests that the industry needs to be constantly challenged in order to achieve its targets for decommissioning. The NDA has a unique position under the Act. It is both a strategic overseer and direct employer. To this end the &apos;National Graduate Programme&apos; is aligned to both the NDA&apos;s previous succession plans and the needs of the industry. Industry needs leadership that challenges the status quo and moves the UK nuclear industry to become best in class; Industry needs a dedicated to programme to address skills shortages and difficult to recruit areas such as, but not exclusively, estimators, schedulers, contract managers, site engineers, decommissioning technicians, safety monitors; The NDA has indicated a &apos;commercial and politically savvy&apos; cohort is required to meet its own internal challenges and to ensure sustainability in its own workforce, and to be sensitive to the needs of customers and suppliers alike; Need to create a more diversified workforce in the nuclear industry and also plan for new skills evolving from research and development breakthroughs; Need to ensure that Tier 1, 2, 3 and 4 contractors invest in the leadership and skills for the future. World Class - delivery will be benchmarked against UK based multinational companies who operate in a global graduate attraction and development marketplace. The graduates targeted will be from leading

  19. Male pattern baldness

    Science.gov (United States)

    Alopecia in men; Baldness - male; Hair loss in men; Androgenetic alopecia ... Male pattern baldness is related to your genes and male sex hormones. It usually follows a pattern of receding hairline and ...

  20. Why are effective potentials &apos;soft&apos;?

    Energy Technology Data Exchange (ETDEWEB)

    Klapp, Sabine H L; Diestler, Dennis J; Schoen, Martin [Stranski-Laboratorium fuer Physikalische und Theoretische Chemie, Sekretariat TC7, Technische Universitaet Berlin, Strasse des 17 Juni 124, D-10623 Berlin (Germany)

    2004-10-20

    This paper is concerned with effective potentials W{sub 1}(R) between interacting supramolecular particles separated by a distance R. We focus on the question of why these potentials are typically &apos;soft&apos;, i.e., remain finite for R {yields} 0 and vary more weakly with R than the underlying interatomic interaction potentials. On the basis of a general expression linking W{sub 1}(R) to the free energy F of the supramolecular system we investigate the origin of the apparent &apos;softness&apos; of W{sub 1}(R) by considering a number of special model systems, starting with an atom and a diatomic molecule. This simple model already yields a W{sub 1}(R) that is finite at R = 0, but W{sub 1}(R) does not exhibit the slowly varying character typical of effective potentials for realistic systems. We then show that the larger length scale is recovered when one introduces both many-body interactions and thermal fluctuations within the framework of a &apos;toy model&apos;, that is disc-shaped supramolecular units composed of thermalized configurations of Lennard-Jones atoms. In this case, W{sub 1}(R) varies so slowly that it can be parametrized by estimating the free energy change associated with the overlap of the discs. The resulting overlap approximation to W{sub 1}(R) behaves qualitatively like ad hoc effective potentials used in mesoscale simulations, such as dissipative particle dynamics. Indeed, on the basis of Monte Carlo simulations and a solution of hypernetted chain integral equations, we find that fluids interacting via DPD and overlap potentials have very similar structural and thermophysical properties. Moreover, the &apos;overlap&apos; fluid (like other &apos;effective&apos; fluids) turns out to be so &apos;soft&apos; that its properties, particularly at high densities, can be very well estimated by a mean-field treatment.

  1. &apos;&apos;Rueckbau 2014&apos;&apos;. KWS Congress regarding decommissioning and dismantling at Zwentendorf nuclear training power plant; &apos;&apos;Rueckbau 2014&apos;&apos;. KWS-Rueckbau-Fachtagung im Schulungskernkraftwerk Zwentendorf

    Energy Technology Data Exchange (ETDEWEB)

    Maassen, Herbert [KRAFTWERKSSCHULE E.V. (KWS), Essen (Germany)

    2015-06-01

    From September 24 to 25, 2014, KRAFTWERKS-SCHULE E.V. (KWS) held the congress &apos;&apos;Rueckbau 2014&apos;&apos;.This first congress about nuclear power plant decommissioning was combined with an exhibition in the fully equipped Zwentendorf nuclear training power plant. The exhibitors had the opportunity to present and test their products in the ambience of a real nuclear power plant, close to original plant components. The visitors got a general overview of the on-site conditions. During the lectures the process of decommissioning and dismantling of a nuclear power plant were described, problems within this process were discussed, and possible solutions were recommended.

  2. Quantifying the &apos;naturalness&apos; of the curvaton model

    Energy Technology Data Exchange (ETDEWEB)

    Lerner, Rose N. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Helsinki Institute of Physics (Finland); Melville, Scott [Helsinki Institute of Physics (Finland)

    2014-02-15

    We investigate the probability of obtaining an observable curvature perturbation, using as an example the minimal curvaton-Higgs (MCH) model. We determine &apos;probably observable&apos; and &apos;probably excluded&apos; regions of parameter space assuming generic initial conditions and applying a stochastic approach for the curvaton&apos;s evolution during inflation. Inflation is assumed to last longer than the N{sub obs}≅55 observable e-folds, and the total number of e-folds of inflation determines the particular ranges of parameters that are probable. For the MCH model, these &apos;probably observable&apos; regions always lie within the range 8 x 10{sup 4} GeV≤m{sub σ}≤2 x 10{sup 7} GeV, where m{sub σ} is the curvaton mass, and the Hubble scale at horizon exit is chosen as H{sub *}=10{sup 10} GeV. Because the &apos;probably observable&apos; region depends on the total duration of inflation, information on parameters in the Lagrangian from particle physics and from precision CMB observables can therefore provide information about the total duration of inflation, not just the last N{sub obs} e-folds. This method could also be applied to any model that contains additional scalar fields to determine the probability that these scalar fields contribute to the curvature perturbation.

  3. On the &apos;efficiency&apos; of futures markets

    Energy Technology Data Exchange (ETDEWEB)

    Bopp, A.E.; Sitzer, Scott

    1988-07-01

    One definition of market efficiency holds that today&apos;s price of an item contains all the price information that there is about that item. That is, today&apos;s price contains information about peoples&apos; expectations about the future. However, in estimating price equations analysts almost exclusively look to the past in developing price forecasting models. This paper examines the question: how do futures prices affect today&apos;s price for heating oil. That is, do futures markets add to the efficiency of markets by conveying information from the future to the present.

  4. PET/CT finding in Castleman&apos;s disease

    Energy Technology Data Exchange (ETDEWEB)

    Han, E. J.; Choi, W. H.; Kim, J. H.; Jeong, Y. A.; Kim, S. H.; Shon, H. S.; Jeong, S. K. [The Catholic University of Korea, Seoul (Korea, Republic of)

    2007-07-01

    Castleman&apos;s disease, also known as angiofollicular lymph node hyperplasia, is a rare and poorly understood disease. This disease is a benign lymphoproliferative disorder and but can progress to lymphoma. Thus accurate diagnosis and treatment is very important. In this report, we present a case of multicentric Castleman&apos;s disease. We retrospectively reviewed a case (40 year-old male) that was histologically confirmed to Castleman&apos;s disease and was performed PET/CT. And from the PET/CT images before and after chemotherapy, peak standard uptake values and sites of abnormal FDG accumulations were recorded. The histological result was a plasma cell variant of Castleman&apos;s disease in both inguinal lymph nodes. PET/CT image showed FDG accumulations in both inguinal areas. And other FDG accumulations were noted in bilateral axillary and iliac regions. He received systemic chemotherapy of 6 cycles. In one month after last chemotherapy, PET/CT image was again performed. Previously noted FDG accumulations in bilateral axillary, iliac, and inguinal regions are seen with diminished intensity. Our result shows decreased intensity of abnormal FDG accumulations after systemic chemotherapy in Castleman&apos;s disease. In conclusion, PET/CT can useful for assessment of therapeutic effect in Castleman&apos;s disease.

  5. Minimum joint space width (mJSW) of patellofemoral joint on standing &apos;'skyline'&apos; radiographs: test-retest reproducibility and comparison with quantitative magnetic resonance imaging (qMRI)

    Energy Technology Data Exchange (ETDEWEB)

    Simoni, Paolo; Jamali, Sanaa; Alvarez Miezentseva, Victoria [CHU de Liege, Diagnostic Imaging Departement, Domanine du Sart Tilman, Liege (Belgium); Albert, Adelin [CHU de Liege, Biostatistics Departement, Domanine du Sart Tilman, Liege (Belgium); Totterman, Saara; Schreyer, Edward; Tamez-Pena, Jose G. [Qmetrics Technologies, Rochester, NY (United States); Zobel, Bruno Beomonte [Campus Bio-Medico University, Diagnostic Imaging Departement, Rome (Italy); Gillet, Philippe [CHU de Liege, Orthopaedic surgery Department, Domanine du Sart Tilman, Liege (Belgium)

    2013-11-15

    To assess the intraobserver, interobserver, and test-retest reproducibility of minimum joint space width (mJSW) measurement of medial and lateral patellofemoral joints on standing &apos;'skyline'&apos; radiographs and to compare the mJSW of the patellofemoral joint to the mean cartilage thickness calculated by quantitative magnetic resonance imaging (qMRI). A couple of standing &apos;'skyline'&apos; radiographs of the patellofemoral joints and MRI of 55 knees of 28 volunteers (18 females, ten males, mean age, 48.5 {+-} 16.2 years) were obtained on the same day. The mJSW of the patellofemoral joint was manually measured and Kellgren and Lawrence grade (KLG) was independently assessed by two observers. The mJSW was compared to the mean cartilage thickness of patellofemoral joint calculated by qMRI. mJSW of the medial and lateral patellofemoral joint showed an excellent intraobserver agreement (interclass correlation (ICC) = 0.94 and 0.96), interobserver agreement (ICC = 0.90 and 0.95) and test-retest agreement (ICC = 0.92 and 0.96). The mJSW measured on radiographs was correlated to mean cartilage thickness calculated by qMRI (r = 0.71, p < 0.0001 for the medial PFJ and r = 0.81, p < 0.0001 for the lateral PFJ). However, there was a lack of concordance between radiographs and qMRI for extreme values of joint width and KLG. Radiographs yielded higher joint space measures than qMRI in knees with a normal joint space, while qMRI yielded higher joint space measures than radiographs in knees with joint space narrowing and higher KLG. Standing &apos;'skyline'&apos; radiographs are a reproducible tool for measuring the mJSW of the patellofemoral joint. The mJSW of the patellofemoral joint on radiographs are correlated with, but not concordant with, qMRI measurements. (orig.)

  6. EXPRESSION OF EGFR AND ITS LIGANDS IN RESPONSE TO TCDD OR RETINOIC ACID IN EGF AND TGFALPHA KO FETAL MOUSE PALATE

    Science.gov (United States)

    EXPRESSION OF EGFR AND ITS LIGANDS IN RESPONSE TO TCDD OR RETINOIC ACID IN EGF AND TGF" KO FETAL MOUSE PALATE. Abbott, Barbara D.1; Boyd, Hadiya2; Wood, Carmen1; Held, Gary1. 1.EPA, ORD, NHEERL, RTD, US EPA, Research Triangle Park, NC, USA. 2MARC Program, NCCU, Durham, NC, USA. <...

  7. Increase in muscarinic stimulation-induced Ca(2+) response by adenovirus-mediated Stim1-mKO1 gene transfer to rat submandibular acinar cells in vivo.

    Science.gov (United States)

    Morita, Takao; Nezu, Akihiro; Tojyo, Yosuke; Tanimura, Akihiko

    2013-10-01

    Adenoviruses have been used for gene transfer to salivary gland cells in vivo. Their use to study the function of salivary acinar cells was limited by a severe inflammatory response and by the destruction of fluid-secreting acinar cells. In the present study, low doses of adenovirus were administered to express Stim1-mKO1 by retrograde ductal injection to submandibular glands. The approach succeeded in increasing muscarinic stimulation-induced Ca(2+) responses in acinar cells without inflammation or decreased salivary secretions. This increased Ca(2+) response was notable upon weak muscarinic stimulation and was attributed to increased Ca(2+) release from internal stores and increased Ca(2+) entry. The basal Ca(2+) level was higher in Stim1-mKO1-expressing cells than in mKO1-expressing and non-expressing cells. Exposure of permeabilized submandibular acinar cells, where Ca(2+) concentration was fixed at 50 nM, to inositol 1,4,5-trisphosphate (IP3) produced similar effects on the release of Ca(2+) from stores in Stim1-mKO1-expressing and non-expressing cells. The low toxicity and relative specificity to acinar cells of the mild gene transfer method described herein are particularly useful for studying the molecular functions of salivary acinar cells in vivo, and may be applied to increase salivary secretions in experimental animals and human in future.

  8. PROTEKSI VAKSIN MONOVALEN DAN KOKTAIL SEL UTUH TERHADAP KO-INFEKSI Mycobacterium fortuitum DAN Aeromonas hydrophila PADA IKAN GURAME, Osphronemus gouramy Uni

    Directory of Open Access Journals (Sweden)

    Uni Purwaningsih

    2014-08-01

    serangan agen patogen. Pemberian vaksin diharapkan dapat merangsang respons imun spesifik dan non spesifik pada ikan. Keberhasilan vaksinasi dipengaruhi oleh konsentrasi antigen, reaksi silang dan kompetisi di antara antigen yang berbeda. Penelitian ini bertujuan untuk menganalisis level proteksi vaksin monovalen dan koktail sel utuh terhadap ko-infeksi M. fortuitum dan A. hydrophila pada ikan gurame. Respons imun perlakuan vaksin monovalen maupun koktail pada gurame pasca ko-infeksi menunjukkan nilai parameter-parameter yaitu: hematokrit, hemoglobin, indeks fagositik, persentase fagositik, titer antibodi, uji respiratory burst (NBT, aktivitas komplemen, dan diferensial leukosit yang berbeda nyata (P<0,05 dibanding kontrol. Vaksin monovalen A. hydrophila menunjukkan nilai RPS sebesar 92,3% dan monovalen M. fortuitum sebesar 78,6% setelah ditantang dengan infeksi tunggal bakteri homolog namun menunjukkan proteksi yang rendah terhadap ko-infeksi. Vaksin koktail 50Mf :50Ah memberikan proteksi yang lebih baik dari vaksin monovalen pasca uji tantang dengan ko-infeksi bakteri M. fortuitum dan A. hydrophila.

  9. Electrical Stimulation Using Conductive Polymer Polypyrrole Counters Reduced Neurite Outgrowth of Primary Prefrontal Cortical Neurons from NRG1-KO and DISC1-LI Mice.

    Science.gov (United States)

    Zhang, Qingsheng; Esrafilzadeh, Dorna; Crook, Jeremy M; Kapsa, Robert; Stewart, Elise M; Tomaskovic-Crook, Eva; Wallace, Gordon G; Huang, Xu-Feng

    2017-02-15

    Deficits in neurite outgrowth, possibly involving dysregulation of risk genes neuregulin-1 (NRG1) and disrupted in schizophrenia 1 (DISC1) have been implicated in psychiatric disorders including schizophrenia. Electrical stimulation using conductive polymers has been shown to stimulate neurite outgrowth of differentiating human neural stem cells. This study investigated the use of the electroactive conductive polymer polypyrrole (Ppy) to counter impaired neurite outgrowth of primary pre-frontal cortical (PFC) neurons from NRG1-knock out (NRG1-KO) and DISC1-locus impairment (DISC1-LI) mice. Whereas NRG1-KO and DISC1-LI exhibited reduced neurite length and number of neurite branches compared to wild-type controls, this was not apparent for cultures on electroactive Ppy. Additionally, the use of the Ppy substrate normalised the synaptophysin and PSD95 protein and mRNA expression whereas both are usually reduced by NRG1-KO or DISC1-LI. Our findings support the utility of Ppy mediated electrical stimulation to prevent the reduction of neurite outgrowth and related synaptic protein expression in the primary PFC neurons from NRG1-KO and DISC1-LI mice, providing proof-of-concept for treating neurodevelopmental diseases including schizophrenia.

  10. Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging.

    Science.gov (United States)

    Arum, Oge; Boparai, Ravneet K; Saleh, Jamal K; Wang, Feiya; Dirks, Angela L; Turner, Jeremy G; Kopchick, John J; Liu, Jun-Li; Khardori, Romesh K; Bartke, Andrzej

    2014-12-01

    In addition to their extended lifespans, slow-aging growth hormone receptor/binding protein gene-disrupted (knockout) (GHR-KO) mice are hypoinsulinemic and highly sensitive to the action of insulin. It has been proposed that this insulin sensitivity is important for their longevity and increased healthspan. We tested whether this insulin sensitivity of the GHR-KO mouse is necessary for its retarded aging by abrogating that sensitivity with a transgenic alteration that improves development and secretory function of pancreatic β-cells by expressing Igf-1 under the rat insulin promoter 1 (RIP::IGF-1). The RIP::IGF-1 transgene increased circulating insulin content in GHR-KO mice, and thusly fully normalized their insulin sensitivity, without affecting the proliferation of any non-β-cell cell types. Multiple (nonsurvivorship) longevity-associated physiological and endocrinological characteristics of these mice (namely beneficial blood glucose regulatory control, altered metabolism, and preservation of memory capabilities) were partially or completely normalized, thus supporting the causal role of insulin sensitivity for the decelerated senescence of GHR-KO mice. We conclude that a delayed onset and/or decreased pace of aging can be hormonally regulated.

  11. Maintain levels of nicotine but reduce other smoke constituents: a formula for &apos;'less-hazardous'&apos; cigarettes

    Energy Technology Data Exchange (ETDEWEB)

    Robinson, J.C.; Young, J.C.; Rickert, W.S.

    1984-09-01

    Twenty-two volunteers who smoked more than 20 cigarettes with &apos;'high'&apos; nicotine yields (0.8 to 1.2 mg) per day participated in an 8-week study designed to test the hypothesis that smoking cigarettes with a constant level of nicotine but reduced deliveries of tar, carbon monoxide, and hydrogen cyanide leads to a decrease in smoke absorption. All subjects smoked their usual high-nicotine brand for the first 3 weeks (P1), and the absorption of smoke constituents was determined from levels of thiocyanate and cotinine in saliva and serum, levels of carbon monoxide in expired air, and levels of carboxyhemoglobin in the blood. During the final 5 weeks (P2), the treatment group (16 subjects) switched to the &apos;'light'&apos; version of their usual brands (similar yields of nicotine but with reduced yields of tar, carbon monoxide, and hydrogen cyanide); the control group (6 subjects) smoked their usual brands for the duration of the study. Average levels of cotinine for the subjects who switched during P2 were not significantly different from those of the control group as was expected. Slight reductions were noted in average expired-air carbon monoxide levels, blood carboxyhemoglobin, and saliva thiocyanate, but these reductions were smaller than anticipated based on brand characteristics. The results suggest that the ratio of smoke constituents is different when individuals, rather than machines, smoke cigarettes. Yields determined under subject-defined conditions are necessary in order to properly evaluate the role of nicotine in the design of &apos;'less-hazardous'&apos; cigarettes.

  12. Body size, carcass and meat quality of three commercial beef categories of &apos;Serrana de Teruel&apos; breed

    Energy Technology Data Exchange (ETDEWEB)

    Ripoll, G.; Albertí, P.; Alvarez-Rodríguez, J.; Blasco, I.; Sanz, A.

    2016-11-01

    The aim of this study was to analyse three commercial beef categories of the &apos;Serrana de Teruel breed&apos; to define the appropriate commercial option. Twenty &apos;Serrana de Teruel&apos; male calves at 9 months were assigned to the commercial beef categories (young bulls, bulls and steers), slaughtered at 12, 22 and 22 months of age, respectively. The in vivo ultrasound backfat thickness was greater than the dorsal fat thickness, and the young bulls and steers had a similar fat thickness, that was greater than the bulls in both areas. The slaughter weight and cold carcass weight were significantly different between the commercial categories. However, the differences were not sufficient to modify the dressing percentage, carcass conformation and fatness degree between the young bulls and bulls. The maximum stress of the muscle at 7 d of ageing was lower in the steers than in the young bulls and bulls. In general, the lightness of the meat in the bulls was lower than that in the young bulls and steers. The subcutaneous fat of the bull carcasses had a vivid colour and stored more carotenoids than that of the young bulls and steers. Hence, bulls produced heavier and better conformed carcasses with more edible meat and less fat than the other categories. However, steers are recommended to produce large carcasses with more trim and cover fat than the other categories. Finally, it seems that bulls are the most suitable commercial category to &apos;Serrana de Teruel&apos; breed. (Author)

  13. Chronic stress does not further exacerbate the abnormal psychoneuroendocrine phenotype of Cbg-deficient male mice.

    Science.gov (United States)

    de Medeiros, Gabriela F; Minni, Amandine M; Helbling, Jean-Christophe; Moisan, Marie-Pierre

    2016-08-01

    Chronic stress leads to a dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis which can constitute a base for pathophysiological consequences. Using mice totally deficient in Corticosteroid binding globulin (CBG), we have previously demonstrated the important role of CBG in eliciting an adequate response to an acute stressor. Here, we have studied its role in chronic stress situations. We have submitted Cbg ko and wild-type (WT) male mice to two different chronic stress paradigms - the unpredictable chronic mild stress and the social defeat. Then, their impact on neuroendocrine function - through corticosterone and CBG measurement - and behavioral responses - via anxiety and despair-like behavioral tests - was evaluated. Both chronic stress paradigms increased the display of despair-like behavior in WT mice, while that from Cbg ko mice - which was already high - was not aggravated. We have also found that control and defeated (stressed) Cbg ko mice show no difference in the social interaction test, while defeated WT mice reduce their interaction time when compared to unstressed WT mice. Interestingly, the same pattern was observed for corticosterone levels, where both chronic stress paradigms lowered the corticosterone levels of WT mice, while those from Cbg ko mice remained low and unaltered. Plasma CBG binding capacity remained unaltered in WT mice regardless of the stress paradigm. Through the use of the Cbg ko mice, which only differs genetically from WT mice by the absence of CBG, we demonstrated that CBG is crucial in modulating the effects of stress on plasma corticosterone levels and consequently on behavior. In conclusion, individuals with CBG deficiency, whether genetically or environmentally-induced, are vulnerable to acute stress but do not have their abnormal psychoneuroendocrine phenotype further affected by chronic stress.

  14. Development of an underground system for transporting people at the enterprise &apos;&apos;Bespremskiye ugolnyye shakhty&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Frei, J.; Horvath, M.; Vago, J.

    1983-01-01

    An examination is made of the stages of development, and advantages are characterized of the mechanized system for transporting people at mines. A technical-economic comparison was made of the possible way to solve the transport problems (variants for the use of cable of winding of the cars, locomotive thrust, belt conveyer transport, freight transport, suspension seats, inclined tracts). Technical characteristics are presented for the thrust devices, cars, loading and unloading stations, and also different equipment used at the Hungarian enterprise &apos;&apos;Bespremskiye ugolnyye shakhty&apos;&apos;.

  15. The effect of prior deformation on the foaming behavior of &apos;'FORMGRIP'&apos; precursor material

    Energy Technology Data Exchange (ETDEWEB)

    Frei, J.; Mortensen, A. [Institute of Materials, Ecole Polytechnique Federale de Lausanne, Lausanne, CH-1015 (Switzerland); Gergely, V.; Clyne, T.W. [Department of Materials Science, University of Cambridge, Pembroke Street, Cambridge CB2 3QZ (United Kingdom)

    2002-10-01

    It is shown that extrusion of &apos;'FORMGRIP'&apos; precursor material prior to baking leads to accelerated foaming and finer, more uniform cell structures. This effect is correlated with microstructural observations made on the precursor materials and on the foams. It is thought that, while extrusion apparently does not extensively fracture the gas-generating hydride particles, it does induce some damage to their protective surface oxide layers. Removal of the porosity normally present in as-cast precursors may also be beneficial. (Abstract Copyright [2002], Wiley Periodicals, Inc.)

  16. Electrolyzed-water generator &apos;SaniBoy&apos;; Eisei jokinsuik kyokyu sochi &apos;SaniBoy&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Inoue, M.; Kakiuchi, H.; Muto, K. [Fuji Electric Co. Ltd., Tokyo (Japan)

    2000-03-10

    In the food industry, injuries due to food poisoning have been increasing. Especially the mass outbreak of food poisoning by Escherichia coli such as O-157 in 1996 gave warning on the importance of food sanitation management. Public efforts such as the Hazard Analysis and Critical Control Point (HACCP) system have been made to prevent food poisoning. Recently, disinfection made by electrolyzing water with some salt added has attracted attention. Fuji Electric has developed the generator &apos;SaniBoy&apos; that produces weak alkaline electrolyzed water without wasting water. The environment-friendly &apos;SaniBoy&apos; will contribute to sanitation in various fields. (author)

  17. Macrophage-specific apoE gene repair reduces diet-induced hyperlipidemia and atherosclerosis in hypomorphic Apoe mice.

    Directory of Open Access Journals (Sweden)

    Nathalie Gaudreault

    Full Text Available BACKGROUND: Apolipoprotein (apo E is best known for its ability to lower plasma cholesterol and protect against atherosclerosis. Although the liver is the major source of plasma apoE, extra-hepatic sources of apoE, including from macrophages, account for up to 10% of plasma apoE levels. This study examined the contribution of macrophage-derived apoE expression levels in diet-induced hyperlipidemia and atherosclerosis. METHODOLOGY/PRINCIPAL FINDINGS: Hypomorphic apoE (Apoe(h/h mice expressing wildtype mouse apoE at ∼2-5% of physiological levels in all tissues were derived by gene targeting in embryonic stem cells. Cre-mediated gene repair of the Apoe(h/h allele in Apoe(h/hLysM-Cre mice raised apoE expression levels by 26 fold in freshly isolated peritoneal macrophages, restoring it to 37% of levels seen in wildtype mice. Chow-fed Apoe(h/hLysM-Cre and Apoe(h/h mice displayed similar plasma apoE and cholesterol levels (55.53±2.90 mg/dl versus 62.70±2.77 mg/dl, n = 12. When fed a high-cholesterol diet (HCD for 16 weeks, Apoe(h/hLysM-Cre mice displayed a 3-fold increase in plasma apoE and a concomitant 32% decrease in plasma cholesterol when compared to Apoe(h/h mice (602.20±22.30 mg/dl versus 888.80±24.99 mg/dl, n = 7. On HCD, Apoe(h/hLysM-Cre mice showed increased apoE immunoreactivity in lesional macrophages and liver-associated Kupffer cells but not hepatocytes. In addition, Apoe(h/hLysM-Cre mice developed 35% less atherosclerotic lesions in the aortic root than Apoe(h/h mice (167×10(3±16×10(3 µm(2 versus 259×10(3±56×10(3 µm(2, n = 7. This difference in atherosclerosis lesions size was proportional to the observed reduction in plasma cholesterol. CONCLUSIONS/SIGNIFICANCE: Macrophage-derived apoE raises plasma apoE levels in response to diet-induced hyperlipidemia and by such reduces atherosclerosis proportionally to the extent to which it lowers plasma cholesterol levels.

  18. An Anti-apoE4 Specific Monoclonal Antibody Counteracts the Pathological Effects of apoE4 In Vivo.

    Science.gov (United States)

    Luz, Ishai; Liraz, Ori; Michaelson, Daniel M

    2016-06-02

    ApolipoproteinE4 (apoE4) is the most prevalent genetic risk factor for Alzheimer's disease (AD) and as such is a promising therapeutic target. This study examined the extent to which the pathological effects of apoE4 can be counteracted in vivo utilizing an immunological approach in which anti-apoE4 antibodies are applied peripherally by i.p. injections into apoE4-targeted replacement mice. Prerequisites for the successful pursuit of this objective are the availability of antibodies that specifically bind brain apoE4 and not apoE3, and demonstrating that direct application of these antibodies into the brain can counteract the effects of apoE4. Accordingly, it was shown that the antiapoE4 monoclonal antibody (mAb) 9D11 binds specifically to brain apoE4 and not apoE3. Direct i.c.v. application of mAb 9D11 prevented the apoE4-driven accumulation of Aβ in hippocampal neurons following activation of the amyloid cascade by inhibiting the Aβ-degrading enzyme neprilysin. These findings provide a proof-of-concept that anti-apoE4 mAb 9D11, when introduced into the brain, can counteract the apoE4 effects in vivo. Subsequent experiments, utilizing repeated i.p. injections of mAb 9D11, resulted in the formation of apoE/IgG complexes specifically in apoE4 mice. This was associated with reversal of the cognitive impairments of apoE4 in the Morris water maze and the novel object recognition test as well as with reversal of key apoE4-driven pathologies including the hyperphosphorylated tau and the reduced levels of the apoER2 receptor. These results indicate that anti-apoE4 immunotherapy counteracts the cognitive and brain pathological effects of apoE4, and suggest that such an approach could also benefit human apoE4 carriers.

  19. Technology &apos;90

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    The US Department of Energy (DOE) laboratories have a long history of excellence in performing research and development in a number of areas, including the basic sciences, applied-energy technology, and weapons-related technology. Although technology transfer has always been an element of DOE and laboratory activities, it has received increasing emphasis in recent years as US industrial competitiveness has eroded and efforts have increased to better utilize the research and development resources the laboratories provide. This document, Technology &apos;90, is the latest in a series that is intended to communicate some of the many opportunities available for US industry and universities to work with the DOE and its laboratories in the vital activity of improving technology transfer to meet national needs. Technology &apos;90 is divided into three sections: Overview, Technologies, and Laboratories. The Overview section describes the activities and accomplishments of the DOE research and development program offices. The Technologies section provides descriptions of new technologies developed at the DOE laboratories. The Laboratories section presents information on the missions, programs, and facilities of each laboratory, along with a name and telephone number of a technology transfer contact for additional information. Separate papers were prepared for appropriate sections of this report.

  20. Comment on &apos;&apos;Teleportation of two-mode squeezed states&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    He Guangqiang; Zhang Jingtao [State Key Lab of Advanced Optical Communication Systems and Networks Department of Electronic Engineering, Shanghai Jiaotong University, Shanghai 200030 (China)

    2011-10-15

    We investigate the teleportation scheme of two-mode squeezed states proposed by Adhikari et al.[S. Adhikari et al., Phys. Rev. A 77, 012337 (2008)]. It uses four-mode entangled states to teleport two-mode squeezed states. The fidelity between the original two-mode squeezed states and teleported ones is calculated. The maximal fidelity value of Adhikari&apos;s protocol is 0.38, which is incompatible with the fidelity definition with the maximal value 1. In our opinion, one reason is that they calculate the fidelity for multimodes Gaussian states using the fidelity formula for single-mode ones. Another reason is that the covariance matrix of output states should be what is obtained after applying the linear unitary Bogoliubov operations (two cascaded Fourier transformations) on the covariance matrix given in Eq. (12) in their paper. These two reasons result in the incomparable results. In addition, Adhikari&apos;s protocol can be simplified to be easily implemented.

  1. Radiobiological study of the radioprotective activity of a natural Iranian compound, &apos;'Shir-Khecht'&apos;; Etude radiobiologique de l&apos;activite radioprotectrice d&apos;un compose naturel Iranien: le &apos;'Shir-Khecht'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Rouhanizadeh, N. [Commissariat a l' Energie Atomique, 92 - Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1968-01-01

    After reviewing the primary mechanisms of the action of ionizing radiation, the possible mechanisms of the action of radioprotective substances, the various chemical structures having a protective effect and the methods for studying chemical radioprotection, the author presents the results he has obtained with natural Iranian product: &apos;'Shir-Khecht'&apos;. Tests with this product at lethal and sublethal doses have been carried out on the rat using various means of introduction. The effect of radiation, both with and without protection, has been studied using histological and biochemical methods. The product examined has, in effect, a protective action; it is, furthermore, non-toxic and active when taken orally. (author) [French] Apres avoir rappele les mecanismes primaires de l&apos;action des rayonnements ionisants, les mecanismes possibles de l&apos;action des substances radioprotectrices, les diverses structures chimiques possedant un effet protecteur et les methodes d&apos;etude de la radioprotection chimique, l&apos;auteur presente les resultats qu&apos;il a obtenus en utilisant un compose naturel iranien: le &apos;'Shir-Khecht'&apos;. Des essais de ce produit, chez le rat, par diverses voies d&apos;introduction, a dose letale et subletale ont ete effectues. L&apos;effet des radiations, avec et sans protection, a ete etudie a l&apos;aide de methodes histologiques et biochimiques. Le compose essaye possede un pouvoir protecteur; il est, de plus, non toxique et actif par voie orale. (auteur)

  2. Development and utilization of a mechanical barrier for large-calibre cavern necks. The &apos;&apos;Spider Plug&apos;&apos;; Entwicklung und Einsatz einer mechanischen Absperrung fuer grosskalibrige Kavernenhaelse. Der &apos;&apos;Spider Plug&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Pfeifer, K.; Maut, D. [UGS GmbH, Mittenwalde (Germany)

    2013-08-01

    An hydraulic separation of a well and the cavern can be necessary for different workover applications, e.g. casing milling or underreaming. The separation is needed to ensure a mud circulation during such operations. In that case a barrier is set after flooding the cavern, which will then be used as a mechanical abutment for the cement bridge. If the diameter of the cavern neck has been enlarged due to e.g. unwanted leaching processes or unstabilized underreaming processes, it might get impossible to set a standard plug with the available technologies into those diameters. Therefore UGS GmbH has developed a mechanical plug, which is set hydraulically. The so called &apos;Spider Plug&apos; is used as basis for a cement bridge and can be removed by drilling after the workover has been done. Depending on the dimension of the setting tool a cavern neck up to 50&apos;&apos; diameter can be plugged by the &apos;Spider Plug&apos;. Up to now a number of successful operations on different locations has shown, that the &apos;Spider Plug&apos; is a practicable and cost-efficient solution for a mechanical abutment of large cavern necks. (orig.)

  3. Intelligent OkiKoSenPBX1 Security Patrol Robot via Network and Map-Based Route Planning

    Directory of Open Access Journals (Sweden)

    Mbaïtiga Zacharie

    2009-01-01

    Full Text Available Problem statement: With an increased demand for security and limited numbers of trained security personnel, some security mangers have a lot of ground to police and limited staff to cover it. To compensate for shortages of security staff and to reduce the stress of security managers, we have developed an intelligent patrol robot system called "OkiKoSenPBX1". The system integrates a variety of sensors to gather environmental information and to detect abnormal events including intruders. Approach: In our approach, the route planning procedure was based on determining a sequence of intermediary goal points or coordinates x and y composing the robot trajectory. Results: A qualitative running experimental evaluation had been performed on the 1st floor of the Okinawa national college of technology as a preliminary practical implementation and its real-time performance was excellent, where a student like-guard can take control of the camera pan and tilt functions remotely. Conclusion: The real-time performance of the developed system that can leave security personnel hands-free for other important tasks is an irresistible system that can be put into practical use in a public offices facility, manufacturing facilities and various construction sites-everywhere there’s a need for advanced frontline security.

  4. Quantitative phosphoproteomics of murine Fmr1-KO cell lines provides new insights into FMRP-dependent signal transduction mechanisms.

    Science.gov (United States)

    Matic, Katarina; Eninger, Timo; Bardoni, Barbara; Davidovic, Laetitia; Macek, Boris

    2014-10-03

    Fragile X mental retardation protein (FMRP) is an RNA-binding protein that has a major effect on neuronal protein synthesis. Transcriptional silencing of the FMR1 gene leads to loss of FMRP and development of Fragile X syndrome (FXS), the most common known hereditary cause of intellectual impairment and autism. Here we utilize SILAC-based quantitative phosphoproteomics to analyze murine FMR1(-) and FMR1(+) fibroblastic cell lines derived from FMR1-KO embryos to identify proteins and phosphorylation sites dysregulated as a consequence of FMRP loss. We quantify FMRP-related changes in the levels of 5,023 proteins and 6,133 phosphorylation events and map them onto major signal transduction pathways. Our study confirms global downregulation of the MAPK/ERK pathway and decrease in phosphorylation level of ERK1/2 in the absence of FMRP, which is connected to attenuation of long-term potentiation. We detect differential expression of several key proteins from the p53 pathway, pointing to the involvement of p53 signaling in dysregulated cell cycle control in FXS. Finally, we detect differential expression and phosphorylation of proteins involved in pre-mRNA processing and nuclear transport, as well as Wnt and calcium signaling, such as PLC, PKC, NFAT, and cPLA2. We postulate that calcium homeostasis is likely affected in molecular pathogenesis of FXS.

  5. Adaptation Of Forgotten Buildings The Example Of The Ruins Of The Kościelec Protestant Church In Piaski

    Directory of Open Access Journals (Sweden)

    Gleń Piotr

    2015-12-01

    Full Text Available Small towns in the Lublin Province are abundant with buildings possessed of outstanding historical and architectural values, representing the culture of past generations. Piaski, about 30 km east of Lublin, also boasts some of the remarkable characteristic of small towns. Not only does it feature post-Jewish tenements, but also a palace and complexes of religious buildings situated on its outskirts. This article focuses on the Kościelec - an unused, dilapidated former Protestant church. Now, works are being carried out that have inspired the Piaski town authorities to try to find a best-use scenario for the former church, in order to preserve its architectural values for future generations. The authors of this article aim to prove the necessity of research and analysis in finding the best new functions for properties whose function has already been imposed. The example of successfully completed revitalisation works at the palace and park complex in Gardzienice, located not far from the baroque Protestant church in Piaski, illustrates the advantages of some of the adaptation processes that can be employed in such buildings.

  6. Ice-brine and planktonic microheterotrophs from Saroma-ko Lagoon, Hokkaido (Japan): quantitative importance and trophodynamics

    Science.gov (United States)

    Sime-Ngando, Télesphore; Juniper, S. Kim; Demers, Serge

    1997-02-01

    Biologists have rarely had the opportunity to investigate the community characteristics and dynamics of heterotrophic microorganisms in highly productive first-year sea ice. In this study, sterile seawater was used as a salinity buffer to extract the ice-brine microheterotroph communities (bacteria, flagellates and ciliates) from a coastal lagoon in Japan (Saroma-ko, Hokkaido; 44°N, 144°E) during the late winter (February—March) of 1992. This procedure reduced osmotic shock during the melting of ice cores and allowed the recovery of up to 323% more cells than the traditional melting method. Most of the organisms were concentrated in the bottom 3-4 cm of the ice, where abundances were up to 33 times higher than in the plankton. In ice and plankton samples, heterotrophic flagellates were dominated by small species (sampling period while protozoa increased or attained their maximum number in late winter, toward the end of the sampling period. These observations support previous suggestions of the existence of a functional microbial food web within the sea-ice community. Heterotrophic flagellate biomass greatly exceeded bacterial biomass in the sea ice (30-60 x). Coupled with similar potential growth rates, this suggests the utilization of additional (non-bacterial) food items by ice-brine flagellates. Finally, the effects of salinity variations (ranging between 15 and 120 psu) on potential microheterotroph growth rates are discussed.

  7. Finding the object&apos;&apos; proceedings addendum

    Energy Technology Data Exchange (ETDEWEB)

    Whiting, M.A.; Devaney, D.M.

    1990-10-01

    The purpose of this workshop was to discuss finding the object -- that is, how software engineers imagine, invent, design, or recycle objects and their behaviors for object-oriented software engineering. The workshop organizers (and, as we subsequently discovered, several of the workshop participants) felt that this issue is crucial to successful object-oriented software engineering (after all, finding objects is what the projects is all about, isn&apos;t it ). Unfortunately, when previous workshops have had the opportunity to review and discuss techniques practitioners use to find objects, too often the results were heated debates on what is an object &apos;&apos; which becomes all consuming. We believed that, given appropriate control over the question of which kind of object&apos;&apos; is being discussed (which meant tell us what object you are trying to find, then tell us your method), a workshop to concentrate on techniques for finding objects would be quite appropriate. 8 refs., 2 figs.

  8. The energy and monetary implications of the &apos;24/7&apos; &apos;always on&apos; society

    Energy Technology Data Exchange (ETDEWEB)

    Loveday, Dennis L. [Department of Civil and Building Engineering, Loughborough University, Loughborough, Leicestershire LE11 3TU (United Kingdom)], E-mail: d.l.loveday@lboro.ac.uk; Bhamra, T.; Tang, T. [Department of Design and Technology, Loughborough University, Loughborough, Leicestershire LE11 3TU (United Kingdom); Haines, V.J.A. [Ergonomics and Safety Research Institute (ESRI), Loughborough University, Loughborough, Leicestershire LE11 3TU (United Kingdom); Holmes, M.J. [ARUP, 13, Fitzroy Street, London W1T 4BR (United Kingdom); Green, R.J. [Institute for Energy Research and Policy, University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom)

    2008-12-15

    This paper reviews the trends in society, technology and energy demand of the past 30 years, together with the growth of the &apos;on-demand&apos; culture. The &apos;24/7&apos; or &apos;always on&apos; society can be defined as one where people demand-and generally receive-what they want &apos;now&apos;. It has grown up in parallel with developments in information technology, which have produced the services needed to meet that demand. Larger numbers of appliances, resulting from greater affluence and disposable income, have increased energy use, despite energy efficiencies in other areas. While monetary factors suggest that changes brought about by the 24/7 society will generally be self-correcting at the macro-economic level, there will nevertheless be effects for individuals, such as potentially severe impacts on the fuel poor as electricity prices rise. We conclude with a view of future directions. As the 24/7 culture continues to grow, there is scope for designers and for information technology to manage and reduce energy consumption. This includes buildings, their services systems, and the mix of new technologies that will be deployed over the next 20 years or so, including the possibilities for data exchange and control at the interface between energy suppliers and consumers, coupled with greater understanding of the behaviour of the consumers themselves.

  9. Deleuze&apos;s Children

    Science.gov (United States)

    Hickey-Moody, Anna Catherine

    2013-01-01

    Children, the image of the child, and the gendered figures of the girl and the boy are thematics that run through the work of Deleuze and feature prominently in his joint writing with Guattari. However, there are many different children in Deleuze&apos;s writings. Various child figures do distinct things in Deleuze&apos;s work. In this article, I…

  10. &apos;&apos;Dural tail&apos;&apos; adjacent to acoustic neuroma on MRI: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Lunardi, P. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy)); Mastronardi, L. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy)); Nardacci, B. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy)); Acqui, M. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy)); Fortuna, A. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy))

    1993-04-01

    A &apos;dural tail&apos; on Gd-DTPA-enhanced MRI has been often observed adjacent to meningiomas and considered to be useful in distinguishing meningioma of the cerebellopontine angle from acoustic neuroma. However, demonstration of a dural tail adjacent to an acoustic neuroma indicates that this sign is not specific. (orig.)

  11. Void effects and the determination of &apos;'patches'&apos; for radiation distribution in heterogeneous multilayer shields

    Energy Technology Data Exchange (ETDEWEB)

    Sayedahmed, F.M.; Makarious, A.S.; Kansouh, W.A. (Atomic Energy Authority, Cairo (Egypt). Reactor and Neutron Physics Dept.)

    1989-01-01

    The effect on radiation distribution in heterogeneous multilayer shield configurations containing cylindrical air-filled voids of different diameters have been investigated. The heterogeneous shield assemblies were placed in front of one of the horizontal channels of the ET-RR-1 reactor. The measurements of {delta}-rays and slow neutrons were carried out using LiF-7 and LiF-6 Teflon disc dosimeters, respectively. It was found that the presence of air-filled voids increases the radiation along and perpendicular to the void axis. An empirical formula has been derived to calculate the radiation distribution in the multilayer shields and a good agreement between the measured and calculated values was obtained. The formulae developed by Chase have been checked experimentally to determine the minimum amount of &apos;'patching'&apos; required on the outside of the voided shields to maintain a uniform emergent radiation distribution on the outer surface of the shielding assembly. The applicability of this formula has been defined and a semi-empirical formula developed to describe the experimental results obtained for the required &apos;'patching'&apos;. (author).

  12. Possibilities for a sustainable development. Muligheter for en baerekraftig utvikling; Analyser paa &apos;&apos;World Model&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Bjerkholt, O.; Johnsen, T.; Thonstad, K.

    1993-01-01

    This report is the final report of a project that the Central Bureau of Statistics of Norway has carried out. The report present analyses of the relations between economic development, energy consumption and emission of pollutants to air in a global perspective. The analyses are based on the &apos;&apos;World Model&apos;&apos;, that has been developed at the Institute for Economic Analysis at New York University. The analyses show that it will be very difficult to obtain a global stabilization of the CO[sub 2] emission on the 1990 level. In the reference scenario of the United Nations report &apos;&apos;Our Common Future&apos;&apos;, the increase of CO[sub 2] emissions from 1990 to 2020 was 73%. Even in the scenario with the most drastic measures, the emissions in 2020 will be about 43% above the 1990 level, according to the present report. A stabilization of the global emissions at the 1990 level will require strong measures beyond those assumed in the model calculations, or a considerable breakthrough in energy technology. 17 refs., 5 figs., 21 tabs.

  13. Crude oil &apos;&apos;Windfall Profit&apos;&apos; Tax Act of 1980

    Energy Technology Data Exchange (ETDEWEB)

    Logan, J.S.

    1980-01-01

    Administrative problems and compliance planning opportunities are the focus of this overview of the windfall profit tax on crude oil, which is actually an excise tax of a portion of domestic crude oil revenues that is tied to the removal of existing price controls on domestic crude oil. The retroactive effective date of the statute meant that the Internal Revenue Service had to draft and issue interim rules in haste, and now has to mesh the interim and final regulations with the petroleum industry&apos;s regular business practices. Producers, purchasers, and other who are affected by the tax should be alert to potential problems as well as planning opportunities that may develop during this process. The author provides a roadmap through the existing interim regulations to help interpret new changes. 204 references.

  14. Results of the Danish &apos;&apos;high efficiency motors campaign&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Malmose, K.

    2000-07-01

    In Denmark energy consultancy (demand side management activities (DSM)) took its first steps in the middle of the 80&apos;ies. The energy consultancy was built up around the Danish electric utilities on which the Danish government imposed the implementation of energy savings for funds collected through the electricity bill (approx. 0.0006 DKK/kWh corresponding to approx. 0.001 ECU). The electric utilities trained energy consultants who specialised in visiting industrial enterprises and counselling on energy consumption, primarily focusing on auxiliary systems like lighting, compressed air, ventilation and heating. Within these areas large savings could be obtained because each company was focusing on the actual production but also because the cost of energy was a fraction of the total costs. (orig.)

  15. KO22 METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  16. Danskernes hellige ko

    DEFF Research Database (Denmark)

    Smed, Sinne

    Denne afhandling omhandler tre unge senmoderne storbydrenges sproglige og sociale hverdag i en skole og i en ungdomsklub på Amager. Fokus for afhandlingen er at belyse, hvordan drengene konstruerer og forhandler identiteter i interaktionen med hinanden og deres omgivelser i forskellige skole- og ...

  17. KO88 METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  18. Photo catalyst; Ko shokubai

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    While titanium oxide is excited by the light, electrons of titanium oxide are taken away by the light energy to form positive holes. Water will be decomposed into hydrogen ion and hydroxy radical (OH) by these positive holes. This hydroxy radical is a strong reactive substance called active oxygen, it decomposes organisms. Besides this photo- catalyst function, the titanium oxide can also make surface of a substance superhydrophilic. The super hydrophilicity results in not forming water drops on the glass surface but spreading all over the surface to prevent a covering of fog on the glass surface. The published patents concerning the photo catalysts were 593 from Jan. 1998 to Jan. 1999. The applicant order is the first TOTO 143, the second Daikin Industry 19, the third Toshiba Raitech, Nitto Denko, Hitachi 17 respectively. (NEDO)

  19. The &apos;&apos;phase velocity&apos;&apos; of nonlinear plasma waves in the laser beat-wave accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Spence, W.L.

    1985-04-01

    A calculational scheme for beat-wave accelerators is introduced that includes all orders in velocity and in plasma density, and additionally accounts for the influence of plasma nonlinearities on the wave&apos;s phase velocity. The main assumption is that the laser frequencies are very large compared to the plasma frequency - under which it is possible to sum up all orders of forward Raman scattering. It is found that the nonlinear plasma wave does not have simply a single phase velocity, but that the beat-wave which drives it is usefully described by a non-local &apos;&apos;effective phase velocity&apos;&apos; function. A time-space domain approach is followed. (LEW)

  20. Gravity&apos;s rainbow

    Energy Technology Data Exchange (ETDEWEB)

    Magueijo, Joao [Theoretical Physics, Blackett Laboratory, Imperial College, Prince Consort Road, London SW7 2BZ (United Kingdom); Smolin, Lee [Perimeter Institute for Theoretical Physics, Waterloo, N2J 2W9 (Canada)

    2004-04-07

    Nonlinear special relativity (or doubly special relativity) is a simple framework for encoding properties of flat quantum spacetime. In this paper, we show how this formalism may be generalized to incorporate curvature (leading to what might be called &apos;doubly general relativity&apos;). We first propose a dual to nonlinear realization of relativity in momentum space, and show that for such a dual the spacetime invariant is an energy-dependent metric. This leads to an energy-dependent connection and curvature, and a simple modification to Einstein&apos;s equations. We then examine solutions to these equations. We find the counterpart to the cosmological metric, and show how cosmologies based upon our theory of gravity may solve the &apos;horizon problem&apos;. We discuss the Schwarzschild solution, examining the conditions for which the horizon is energy dependent. Finally, we find the weak field limit.

  1. EUGRIS: &apos;&apos;European Substainable Land and Groundwater Management Information System&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Frauenstein, J. [Federal Environmental Agency (UBA), Berlin (Germany)

    2003-07-01

    The presentation outlines and Accompanying Measure with the FP 5 to develop an web based EUropean Sustainable Land and GRoundwater Management Information System information system (EUGRIS). The management of contaminated land and groundwater requires an interdisciplinary approach and a considerable amount of supporting technical information and knowledge. EUGRIS will provide a generally available comprehensive and overarching information and innovation resource, to support both research and practical contaminated land and groundwater management. EUGRI is a gateway to provide a &apos;one stop shop&apos; for information provided by research projects, legislation, standards, best practice and other technical guidance and policy/regulatory publications from the EC, participating Member and Accession States and from various international networks dealing with groundwater and land management issues. Different types of user can access information through different windows according to their needs. EUGRIS will provide its visitors with summary information (digests) and links to sources of more detailed and/or original information in a scaleable holistic and contexturally meaningful way. EUGRIS is being built in three stages: the design of the information system, the development of its software implementation, and the population of the system with information. The presentation is focussed on the concept of the development of the information system with the individual work packages. In the second part of the lecture in particular the work procedures are presented for the content wise replenishment by EUGRIS. The data collation for the proven pilot countries and the production of a European research data base, which opens contents and results of European-wide locked and current projects, form the emphasis thereby. (orig.)

  2. Fus1 KO mouse as a model of oxidative stress-mediated sporadic Alzheimer’s disease: circadian disruption and long-term spatial and olfactory memory impairments.

    Directory of Open Access Journals (Sweden)

    Guillermo Coronas-Samano

    2016-11-01

    Full Text Available Insufficient advances in the development of effective therapeutic treatments of sporadic Alzheimer's Disease (sAD to date are largely due to the lack of sAD-relevant animal models. While the vast majority of models do recapitulate AD's hallmarks of plaques and tangles by virtue of tau and/or beta amyloid overexpression, these models do not reflect the fact that in sAD (unlike familial AD these genes are not risk factors per se and that other mechanisms like oxidative stress, metabolic dysregulation and inflammation play key roles in AD etiology. Here we characterize and propose the Fus1 KO mice that lack a mitochondrial protein Fus1/Tusc2 as a new sAD model. To establish sAD relevance, we assessed sAD related deficits in Fus1 KO and WT adult mice of 4-5 months old, the equivalent human age when the earliest cognitive and olfactory sAD symptoms arise. Fus1 KO mice showed oxidative stress (increased levels of ROS, decreased levels of PRDX1, disruption of metabolic homeostasis (decreased levels of ACC2, increased phosphorylation of AMPK, autophagy (decreased levels of LC3-II, PKC (decreased levels of RACK1 and calcium signaling (decreased levels of Calb2 in the olfactory bulb and/or hippocampus. Mice were behaviorally tested using objective and accurate video tracking (Noldus, in which Fus1 KO mice showed clear deficits in olfactory memory (decreased habituation/cross-habituation in the short and long term, olfactory guided navigation memory (inability to reduce their latency to find the hidden cookie, spatial memory (learning impairments on finding the platform in the Morris water maze and showed more sleep time during the diurnal cycle. Fus1 KO mice did not show clear deficits in olfactory perception (cross-habituation, association memory (passive avoidance or in species-typical behavior (nest building and no increased anxiety (open field, light-dark box or depression/anhedonia (sucrose preference at this relatively young age. These

  3. Technology evaluation report: SITE (Superfund Innovative Technology Evaluation) program demonstration test. The American Combustion Pyretron Thermal Destruction System at the US EPA&apos;s (Environmental Protection Agency&apos;s) combustion research facility

    Energy Technology Data Exchange (ETDEWEB)

    Waterland, L.; Lee, J.W.

    1989-04-01

    A series of demonstration tests of the American Combustion, Inc., Thermal Destruction System was performed under the SITE program. This oxygen-enhanced combustion system was retrofit to the rotary-kiln incinerator at EPA&apos;s Combustion Research Facility. The system&apos;s performance was tested firing contaminated soil from the Stringfellow Superfund Site, both alone and mixed with a coal tar waste (KO87). Comparative performance with conventional incinerator operation was also tested. Compliance with the incinerator performance standards of 99.99% principal organic hazardous constituents (POHC) destruction and removal efficiency and particulate emissions of less than 180 mg/dscm at 7% O2 was measured for all tests. The Pyretron system was capable of in-compliance performance at double the mixed waste feedrate and at a 60% increase in batch waste charge mass than possible with conventional incineration. Scrubber blowdown and kiln ash contained no detectable levels of any of the POHCs chosen.

  4. Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer's disease.

    Science.gov (United States)

    Hou, Xu; Adeosun, Samuel O; Zhang, Qinli; Barlow, Brett; Brents, Melissa; Zheng, Baoying; Wang, Junming

    2015-01-01

    Alzheimer's disease (AD), the most common form of dementia, disproportionately affects women in both prevalence and severity. This increased vulnerability to AD in women is strongly associated with age-related ovarian hormone loss and apolipoprotein E 4 allele (ApoE4), the most important genetic risk factor for sporadic AD. Up to date, the mechanism involved in the interaction between ApoE4 and sex/gender in AD is still unclear. This study evaluated the sex-dependent ApoE4 effects on learning and memory, Aβ deposition and potential mechanisms, using mice bearing both sporadic (ApoE4) and familial (APPSwe, PS1M146V, tauP301L; 3xTg) AD risk factors and compared with sex- and age-matched 3xTg or nonTg mice. Compared to nonTg mice, transgenic mice of both sexes showed spatial learning and memory deficits in the radial arm water maze and novel arm discrimination tests at 20 months of age. However, at 10 months, only ApoE4/3xTg mice showed significant learning and memory impairment. Moreover, molecular studies of hippocampal tissue revealed significantly higher protein levels of Aβ species, β-site APP cleavage enzyme (BACE1) and Sp1, a transcription factor of BACE1, in female ApoE4/3xTg when compared with female nonTg, female 3xTg, and male ApoE4/3xTg mice. Significantly increased BACE1 enzymatic activities were observed in both male and female mice carrying ApoE4; however, only the females showed significant higher BACE1 expressions. Together, these data suggest that ApoE4 allele is associated with increased BACE1 enzymatic activity, while female sex plays an important role in increasing BACE1 expression. The combination of both provides a molecular basis for high Aβ pathology and the resultant hippocampus-dependent learning and memory deficits in female ApoE4 carriers.

  5. Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer’s disease

    Directory of Open Access Journals (Sweden)

    Xu eHou

    2015-10-01

    Full Text Available Alzheimer’s disease (AD, the most common form of dementia, disproportionately affects women in both prevalence and severity. This increased vulnerability to AD in women is strongly associated with age-related ovarian hormone loss and apolipoprotein E 4 allele (ApoE4, the most important genetic risk factor for sporadic AD. Up to date, the mechanism involved in the interaction between ApoE4 and sex/gender in AD is still unclear. This study evaluated the sex-dependent ApoE4 effects on learning and memory, Aβ deposition and potential mechanisms, using mice bearing both sporadic (ApoE4 and familial (APPSwe, PS1M146V, tauP301L; 3xTg AD risk factors and compared with sex- and age-matched 3xTg or nonTg mice. Compared to nonTg mice, transgenic mice of both sexes showed spatial learning and memory deficits in the radial arm water maze and novel arm discrimination tests at 20 months of age. However, at 10 months, only ApoE4/3xTg mice showed significant learning and memory impairment. Moreover, molecular studies of hippocampal tissue revealed significantly higher protein levels of Aβ species, β-site APP cleavage enzyme (BACE1 and Sp1, a transcription factor of BACE1, in female ApoE4/3xTg when compared with female nonTg, female 3xTg and male ApoE4/3xTg mice. Significantly increased BACE1 enzymatic activities were observed in both male and female mice carrying ApoE4; however, only the females showed significant higher BACE1 expressions. Together, these data suggest that ApoE4 allele is associated with increased BACE1 enzymatic activity, while female sex plays an important role in increasing BACE1 expression. The combination of both provides a molecular basis for high Aβ pathology and the resultant hippocampus-dependent learning and memory deficits in female ApoE4 carriers.

  6. Biological effect and tumor risk of diagnostic x-rays. The &apos;&apos;war of the theories&apos;&apos;; Biologische Wirkung und Tumorrisiko diagnostischer Roentgenstrahlen. Der &apos;&apos;Krieg der Modelle&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Selzer, E.; Hebar, A. [Medizinische Universitaet Wien, Abteilung fuer Strahlenbiologie, Klinik fuer Strahlentherapie, Wien (Austria)

    2012-10-15

    Since the introduction of ionizing radiation as a treatment and diagnostic tool in humans, scientists have been trying to estimate its side effects and potential health risks. There is now ample evidence for the principal existence of a direct relationship between higher doses and the risks of side effects. Most of the uncertainties lie in the field of low-dose effects especially with respect to the risk of cancer induction. Low-dose effects are usually of relevance in diagnostic medicine while high-dose radiation effects are typically observed after radiotherapeutic treatment for cancer or after nuclear accidents. The current state of the &apos;&apos;war of theories&apos;&apos; may be summarized as follows: one group of scientists and health regulatory officials favors the hypothesis that there is no threshold dose, i.e. the linear-no-threshold hypothesis (LNT) of radiation which can be regarded as safe. On the contrary, the critics of this hypothesis suggest that the risks of doses below 50 mSv are not measurable or even of clinical relevance and are not adequately described by a linear dose-response relationship. The aim of this article is to summarize the major unresolved issues in this field. Arguments are presented why the validity of the LNT model in the low-dose range should be regarded as at least inconsistent and is thus questionable. (orig.) [German] Seit der Einfuehrung ionisierender Strahlen als ein Mittel zur Behandlung und Diagnose beim Menschen haben Wissenschaftler versucht, ihre Nebenwirkungen und potenziellen Risiken fuer die Gesundheit einzuschaetzen. Es gibt nun ausreichende Evidenz fuer das grundsaetzliche Vorliegen einer direkten Beziehung zwischen hoeheren Dosen und Nebenwirkungsrisiken. Die meisten Unsicherheiten liegen auf dem Gebiet der Niedrigdosisforschung v. a. im Hinblick auf das Risiko der Induktion von Krebs. Niedrigdosiseffekte sind ueblicherweise von Bedeutung in der diagnostischen Medizin, waehrend Hochdosisbestrahlungseffekte

  7. EAWAG Forum Chriesbach - A &apos;sustainable&apos; new building; EAWAG Forum Chriesbach - Ein &apos;nachhaltiger Neubau&apos; / A &apos;sustainable&apos; new building

    Energy Technology Data Exchange (ETDEWEB)

    Bundi, U. [EAWAG, Duebendorf (Switzerland); Gantenbein, K. [Hochparterre, Zuerich (Switzerland); Preisig, H. [Prof. Hansruedi Preisig, Zuerich (Switzerland); Kasser, U. [Ueli Kasser, Zuerich (Switzerland)

    2006-07-01

    This monograph describes the &apos;Forum Chriesbach&apos; - a new building for Swiss Federal Institute of Aquatic Science and Technology EAWAG in Duebendorf, Switzerland. The history behind the project and its sustainable concept are discussed. Basic Ideas and an analogy to a typical Swiss farmhouse of earlier centuries are examined. The teamwork that was needed for the building&apos;s realisation is also noted. Architectural topics and the treatment of the building as a total system are discussed. Further topics include water, sanitary installations, material ecology and grey energy. Further, the monograph deals with the realisation of the building, presents key figures and energy balances and comments on the planning and building processes involved.

  8. Oriental medicine Kyung-Ok-Ko prevents and alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats.

    Science.gov (United States)

    Jang, Minhee; Lee, Min Jung; Lee, Jin Moo; Bae, Chun-Sik; Kim, Sung-Hoon; Ryu, Jong Hoon; Cho, Ik-Hyun

    2014-01-01

    Kyung-Ok-Ko (KOK), a traditional herbal prescription composed of Rehmannia glutinosa Liboschitz var. purpurae, Lycium chinense, Aquillaria agallocha, Poria cocos, Panax ginseng, and honey, has been widely used in traditional Oriental medicine as a vitalizing medicine or as the prescription for patients with age-associated disorders such as amnesia and stroke. However, the potential protective value of KOK for the treatment of polycystic ovarian syndrome (PCOS) is largely unknown. We investigated whether pre-administration (daily from 2 hours before PCOS induction) and post-administration (daily after induction of PCOS) of KOK (0.5, 1.0, and 2.0 g/kg/day, p.o.) could have a protective effect in a dehydroepiandrosterone (DHEA, s.c.)-induced PCOS rat model. Pre-administration of KOK significantly decreased the elevated body weight and ovary weight, elevated size and number of follicular cysts, elevated level of serum glucose, and estradiol after DHEA injection. KOK reduced the elevated percentage of CD8 (+) T lymphocytes in lymph nodes, the elevated mRNA expression of CD11b and CD3 in ovaries, and infiltration of macrophages in ovarian tissue with PCOS. KOK diminished the increased mRNA expression of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), chemokines (IL-8, MCP-1), and iNOS in the ovaries, and increased the reduced mRNA expression of growth factors (EGF, TGF-β) by DHEA injection. Post-administration of KOK also improved the DHEA-induced PCOS-like symptoms, generally similar to those evident from pre-administration of KOK. KOK may effectively prevent and improve DHEA-induced PCOS via anti-inflammatory action, indicating its preventive and therapeutic potential for suppressing PCOS.

  9. Content of metals and metabolites in honey originated from the vicinity of industrial town Košice (eastern Slovakia).

    Science.gov (United States)

    Kováčik, Jozef; Grúz, Jiří; Biba, Ondřej; Hedbavny, Josef

    2016-03-01

    Composition of three types of honey (mixed forest honey and monofloral-black locust and rapeseed honeys) originated from the vicinity of an industrial town (Košice, Slovak Republic) was compared. Higher content of minerals including toxic metals in forest honey (1358.6 ng Ni/g, 85.6 ng Pb/g, and 52.4 ng Cd/g) than in rapeseed and black locust honeys confirmed that botanical origin rather than the distance for eventual source of pollution (steel factory) affects metal deposition. Benzoic acid derivatives were typically more accumulated in forest but cinnamic acid derivatives and some flavonoids in rapeseed honey (in free and/or glycoside-bound fraction). In terms of quantity, p-hydroxybenzoic and p-coumaric acids were mainly abundant. Total phenols, thiols, and proteins were abundant in forest honey. Some metals and phenols contributed to separation of honeys based on principal component analysis (PCA). Native amount of 5-(hydroxymethyl)furfural was not related to honey type (~11 μg/g) and was elevated after strong acid hydrolysis (200-350 μg/g) but it did not interfere with the assay of phenols by Folin-Ciocalteu reagent. This is the first report of metals and metabolites in the same study, and data are discussed with available literature. We conclude that black locust (acacia) honey is the most suitable for daily use and that central European monofloral honeys contain lower amounts of toxic metals in comparison with other geographical regions.

  10. Single-centre review of radiologically guided percutaneous nephrostomy using &apos;mixed&apos; technique: Success and complication rates

    Energy Technology Data Exchange (ETDEWEB)

    Montvilas, Paulius, E-mail: paulmont@rm.dk [Department of Radiology, Aarhus University Hospital, Skejby, Brendstrupgardsvej 100, 8200 Aarhus N (Denmark); Solvig, Jan, E-mail: jansolvi@rm.dk [Department of Radiology, Aarhus University Hospital, Skejby, Brendstrupgardsvej 100, 8200 Aarhus N (Denmark); Bjerklund Johansen, Truls Erik, E-mail: tebj@skejby.rm.dk [Department of Urology, Aarhus University Hospital, Skejby, Brendstrupgardsvej 100, 8200 Aarhus N (Denmark)

    2011-11-15

    Aim: A review of complication and success rates of the &apos;mixed&apos; technique in percutaneous nephrostomy using both the Seldinger and one-step techniques in dilated and non-dilated systems. Materials and methods: We retrospectively analysed 500 percutaneous nephrostomies in dilated an non-dilated systems in 353 patients from 2006 to 2007 (208 males (range 19-95 years), 127 females (range 27-91 years) and 21 children (range 3 months-16 years: 6 females, 15 males)). Percutaneous nephrostomy was considered successful if catheter was placed in renal pelvis and drained urine spontaneously. Successful percutaneous nephrostomies were classified as primary (renal system drained instantly) or postponed (drainage achieved within 24 h after initial failure). Number of complications was registered. Results: All of the 500 nephrostomies were successful within 24 h (96.2% primary; 3.8% postponed). The success rate of primary nephrostomy in dilated and non-dilated systems was 98.2% and 82%, respectively. Major complications occurred in 0.45% and minor complications in 14.2%. Conclusion: Percutaneous nephrostomy using the &apos;mixed&apos; technique is very successful in dilated systems, is not superior to other PCN techniques in non-dilated systems and has a very low rate of major complications.

  11. Documentation to the workshop &apos;Cluster in the environmental protection economy&apos;; Dokumentation zum Workshop &apos;&apos;Cluster in der Umweltschutzwirtschaft&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-12-11

    Within the workshop &apos;Cluster in the environmental protection economy&apos; at the Umweltbundesamt (Dessau-Rosslau, Federal Republic of Germany) at 27th November, 2008, the following lectures were held: (a) Which contribution can cluster and cluster politics contribute to the promotion of the environmental protection economy? (Harald Legler); (b) Cluster in the environmental protection economy: Targets and expectations (Dieter Rehfeld); (c) Demands at the management of clusters (Karin Hoerhan); (d) Demands at the cluster politics in the environmental protection economy (Bernhard Hausberg); (e) Photovoltaics in Eastern Germany (Johann Wackenbauer); (f) Automotive industry in Bergisches Land (Thomas Lemken); (g) Competence centre environment Augsburg-Schwaben (Egon Beckord).

  12. Estimation of doses to patients from &apos;'complex'&apos; conventional X-ray examinations

    Energy Technology Data Exchange (ETDEWEB)

    Calzado, A.; Vano, E.; Moran, P.; Ruiz, S.; Gonzalez, L. (Universidad Complutense de Madrid (Spain). Catedra de Fisica Medica); Castellote, C. (Hospital Militar Central ' ' Gomez Ulla' ' , Madrid (Spain). Dept. de Radiologia)

    1991-06-01

    A numerical method has been developed to estimate organ doses and effective dose-equivalent for patients undergoing three &apos;complex&apos; examinations (barium meal, barium enema and intravenous urography). The separation of radiological procedures into a set of standard numerical views is based on the use of Monte Carlo conversion factors and measurements within a Remab phantom. Radiation doses measured in a phantom for such examinations were compared with predictions of the &apos;'numerical'&apos; method. Dosimetric measurements with thermoluminescent dosemeters attached to the patient&apos;s skin along with measurements of the dose-area product during the examination have enabled the derivation of organ doses and to estimate effective dose-equivalent. Mean frequency weighted values of dose-area product, energy imparted to the patient, doses to a set of organs and effective dose-equivalent in the area of Madrid are reported. Comparisons of results with those from similar surveys in other countries were made. (author).

  13. [Male urinary incontinence

    NARCIS (Netherlands)

    Boer, TA de; Heesakkers, J.P.F.A.

    2008-01-01

    *Urinary incontinence in males is gaining increasingly more attention. *Male urinary incontinence can be classified as storage incontinence due to overactive bladder syndrome or stress incontinence due to urethral sphincter dysfunction. *Most patients benefit from the currently available treatment o

  14. Male pattern baldness (image)

    Science.gov (United States)

    Male pattern baldness is a sex-linked characteristic that is passed from mother to child. A man can more accurately predict his chances of developing male pattern baldness by observing his mother's father than by looking ...

  15. Rate constant and thermochemistry for K + O2 + N2 = KO2 + N2

    DEFF Research Database (Denmark)

    Sorvajärvi, Tapio; Viljanen, Jan; Toivonen, Juha

    2015-01-01

    The addition reaction of potassium atoms with oxygen has been studied using the collinear photofragmentation and atomic absorption spectroscopy (CPFAAS) method. KCl vapor was photolyzed with 266 nm pulses and the absorbance by K atoms at 766.5 nm was measured at various delay times with a narrow...... over 250-1320 K, with an error limit of a factor of 1.5. A vant Hoff analysis constrained to fit the computed ΔS298 yields a K-O2 bond dissociation enthalpy of 184.2 ± 4.0 kJ mol-1 at 298 K and ΔfH298(KO2) = -95.2 ± 4.1 kJ mol-1. The corresponding D0 is 181.5 ± 4.0 kJ mol-1. This value compares well...

  16. [Rehabilitation in the View of Small and Midsized Enterprises: Knowledge, Appreciation and Possibilities to Cooperate - Results of the KoRB-Project

    DEFF Research Database (Denmark)

    Hesse, B.; Heuer, J.; Gebauer, E.

    2008-01-01

    of experience). However the financial burden is perceived as less problematic. Employers favour alternative rehab models, which allow part-time working. Many employees, who expressed a need for rehabilitation, refrained from applying for rehabilitation on account of worries about loosing their employment. Both......The experiences of small and midsized enterprises (SME) with medical rehabilitation were investigated in the KoRB-Study (KoRB= KOoperation Rehabilitation und Betrieb) for the first time. Opportunities for a targeted cooperation between the statutory pension insurance and these enterprises were...... came from the occupational health practitioners, worst ratings from the employees. All groups would welcome more accessible information in case of need. Medical rehabilitation in its standard form of "3 weeks full-time" often causes severe logistic problems in SME (e. g., replacement of employee, loss...

  17. Quantitatively understanding reduced xylose fermentation performance in AFEX™ treated corn stover hydrolysate using Saccharomyces cerevisiae 424A (LNH-ST) and Escherichia coli KO11.

    Science.gov (United States)

    Jin, Mingjie; Balan, Venkatesh; Gunawan, Christa; Dale, Bruce E

    2012-05-01

    Reduced xylose fermentation performance has been an issue during fermentation of AFEX™ hydrolysate using Saccharomyces cerevisiae 424A (LNH-ST) or Escherichia coli KO11. To better understand why fermentation performance is reduced, we quantitatively studied the effects of compounds present in the fermentation broth on xylose consumption. The compounds include biomass degradation products, ethanol and fermentation metabolites. The xylose consumption capability of E. coli KO11 was almost totally inhibited by the presence of both degradation products and ethanol. On the other hand, for S. cerevisiae 424A, 89% reduction of xylose consumption rate was found during hydrolysate fermentation. Degradation products, ethanol and fermentation metabolites were responsible for 32%, 24% and 33% of such reduction, respectively. Those results suggest that to further improve the xylose fermentation in hydrolysate, strains should be selected not only for degradation products tolerance but also for ethanol and fermentation metabolites tolerance.

  18. Variazione poetica, metamorfosi, ibridazione linguistica: scritture del corpo e identità in trasformazione nell'opera di Tawada Yōko

    Directory of Open Access Journals (Sweden)

    Francesco Eugenio Barbieri

    2014-05-01

    Full Text Available A recurring theme in the work of Japanese writer Tawada Yōko is metamorphosis, intended first and foremost as body transformation, as the introduction in the story of an element of magic, and used to question the monolithic notion of identity in the global dimension of migrant citizenship. On the other hand linguistic metamorphosis - i.e. morphological, grammatical and syntactical hybridization between Japanese and German language - is another strategy frequently used by the writer to improve her textual expressive potential.This paper aims at presenting a brief analysis of the use of metamorphosis, both in its narrative and linguistic dimension, with reference to Tawada Yōko's Das Bad (1989, Opium für Ovid (2000 and Abenteuer der Deutschen Grammatik (2010.

  19. &apos;Catapult&apos; offshore renewables into commercial use

    Energy Technology Data Exchange (ETDEWEB)

    Block, Elizabeth

    2012-07-01

    In February, the Technology Strategy Board, the UK&apos;s government innovation agency, appointed a consortium to set up the Offshore Renewable Energy Catapult centre, with Sterling Pounds 50 million to be spent over five years. (orig.)

  20. Container design testing for the final repository Konrad - experiences with respect to so called &apos;'old'&apos; containers; Bauartpruefungen an Behaeltern fuer das Endlager KONRAD. Erfahrungen bezueglich sog. &apos;'Alt'&apos;-Behaelter

    Energy Technology Data Exchange (ETDEWEB)

    Noack, Volker; Voelzke, Holger; Nieslony, Gregor; Kovacs, Oliver; Hagenow, Peter [BAM Bundesanstalt fuer Materialforschung und -pruefung (Germany)

    2009-07-01

    The Konrad ore mine is a final repository for low- and intermediate-level radioactive waste in Germany. The demand for final storage suitable containers is increasing. The authors describe tests of so called &apos;'old'&apos; containers for qualification with respect to the appropriateness for final disposal. BAM (Bundesanstalt fuer Materialpruefung) has test facilities for drop tests and fire tests. The testing requirements for all available container types are discussed, including the boundary conditions with respect to the supposed waste properties, conditioning and loading. The project of container design testing is aimed to the possibility of a continuous recording of a large amount of waste packages for the final repository Konrad that allows a short-term backtracking of the relevant data for quality assurance.

  1. Characterisation of epeiric &apos;'layer-cake'&apos; carbonate reservoirs: Upper Muschelkalk (Middle Triassic), the Netherlands

    Energy Technology Data Exchange (ETDEWEB)

    Borkhataria, R.; Aigner, T.; Poeppelreiter, M.C.; Pipping, J.C.P. [Shell International Exploration and Production Inc., Houston, TX (United States)

    2005-04-01

    Upper Muschelkalk (Middle Triassic) carbonates produce natural gas at Coevorden field in the NE Netherlands. This is currently the only field that produces gas from this succession although several other prospects have been identified nearby. In order to help develop these hydrocarbons, this study proposes a facies and reservoir model of the Upper Muschelkalk in the NE Netherlands together with a regional framework intended to assist in further evaluation. Distribution of facies and reservoir properties of the Upper Muschelkalk carbonates in the NE Netherlands indicate deposition on a storm-dominated epeiric ramp with a very low gradient. The predominantly muddy and marly lithofacies types in proximal and distal parts of the ramp gradually interfinger with a shoreline-detached &apos;'shoal'&apos;-like ooidal grainstone complex. The best reservoir quality (permeability up to 60 mD) is recognised within dolomitised peloid ooid grainstones. These are interpreted as high-energy backshoal deposits. Reservoir quality decreases in the limestone-dominated &apos;'shoal'&apos; facies and the muddier foreshoal facies. A four-fold hierarchy of depositional cycles describes the systematic and thus predictable vertical variation in reservoir quality (permeability) and quantity (net-to-gross). High-resolution correlation suggests that medium-scale cycles (5 to 15 metres thick) can be traced for hundreds of kilometres. Small-scale cycles (1 to 3 metres thick) are persistent for several tens of kilometres and have sheet-like geometries. Individual reservoir units (several decimetres thick) appear to be laterally continuous over a maximum of a few kilometres although internal flow barriers might be expected. Mapping of Upper Muschelkalk thickness and facies has clearly defined backshoal, &apos;'shoal'&apos; and foreshoal facies belts with distinctly different reservoir characteristics. Typically, reservoir quality and quantity decrease with increasing

  2. Swiss &apos;Electricity&apos; Research Programme 2004-2007; Konzept des Forschungsprogramms &apos;Elektrizitaet&apos; 2004 - 2007

    Energy Technology Data Exchange (ETDEWEB)

    Brueniger, R.

    2004-07-01

    This report issued by the Swiss Federal Office of Energy (SFOE) provides details on Swiss research in the electricity area that is foreseen for the period 2004-2007. The report discusses the current state of electricity research and the strategic goals for the period and presents the organisations involved and their previous work. The general main areas of interest addressed by the programme are noted, such as the storage and transport of electricity as well as its use in communication technologies, motors, domestic appliances and industrial applications. Figures are presented on the programme&apos;s finances and the concept of &apos;trend-watching&apos; groups is briefly addressed.

  3. IMMUNOCHEMICAL STUDIES IN A PATIENT WITH WALDEN-STROM&apos;S MACROGLOBULINEMIA

    Directory of Open Access Journals (Sweden)

    M. Mir-Ahmadian

    1978-01-01

    Full Text Available Waldenstrom&apos;s macroglobulinemia was studied in a 46 year old Iranian male with anemia, bleeding, ecchymose and splenomegaly. The diagnosis of Macroglobulinemia was established by the presence of veryhigh level of IgM paraprotein in sera which was detectable by imrnunoelectrophoresis and rocket immunoelectrophoresis, and by the presence of bone marrow infiltration of plasmoc ytes. Family studies revealed a high IgM level in one of the patient&apos;s daughters.

  4. What does &apos;'Platinum'&apos; mean? Reflections on the development of sustainability assessment methods; Was bedeutet &apos;'Platin'&apos;? - Zur Entwicklung von Nachhaltigkeitsbewertungsverfahren

    Energy Technology Data Exchange (ETDEWEB)

    Gertis, Karl [Lehrstuhl fuer Bauphysik, Universitaet Stuttgart (Germany); Hauser, Gerd [echnischen Universitaet Muenchen (Germany); Sedlbauer, Klaus [Universitaet Stuttgart (DE). Fraunhofer-Institut fuer Bauphysik (IBP); Sobek, Werner [Universitaet Stuttgart (DE). Institut fuer Leichtbau Entwerfen und Konstruieren (ILEK)

    2008-08-15

    The current political discussion on climate change is heavily biased towards CO{sub 2} balance, energy consumption and energy costs associated with rising energy prices. The good news is that the German Government covers sustainability in the construction sector, including - and indeed going far beyond - energy conservation. To this end the German Sustainable Building Council (DGNB) was formed in 2007, although it is worth noting that Great Britain introduced a relatively advanced sustainability assessment method referred to as BREEAM as early as 1990, an enhanced version of which was released in the USA in 1995 under the name of LEED. This article tries to show &apos;'rootstocks'&apos; for the sustainability assessment, to set up a classification system for criteria, and to derive consequences. (Abstract Copyright [2008], Wiley Periodicals, Inc.) [German] In der derzeitigen politischen Diskussion ueber die Klimaveraenderung wird der CO{sub 2}-Bilanz und dem Energieverbrauch bzw. den mit steigenden Energiepreisen verbundenen Energiekosten eine fast ueberlastige Bedeutung beigemessen. Umso erfreulicher ist es, dass sich die Bundesregierung mit einem Leitfaden auch der Nachhaltigkeit des Bauens annimmt, welche die Energieeinsparung einschliesst, aber weit ueber diese hinausgeht, und dass sich hierzu im Jahre 2007 - wenn auch im internationalen Vergleich spaet - die Deutsche Gesellschaft fuer nachhaltiges Bauen (DGNB) gebildet hat; verspaetet deshalb, weil in Grossbritannien mit BREEAM bereits 1990 ein relativ ausgereiftes Nachhaltigkeitsbewertungsverfahren bekannt geworden war, auf das in den USA mit LEED 1995 aufgebaut wurde. Die vorliegende Arbeit versucht, &apos;'Grundstoecke'&apos; fuer die Nachhaltigkeitsbeurteilung aufzuzeigen, ein Kriterien-Ordnungssystem aufzubauen und daraus einige Konsequenzen abzuleiten. (Abstract Copyright [2008], Wiley Periodicals, Inc.)

  5. A &apos;missing&apos; family of classical orthogonal polynomials

    Energy Technology Data Exchange (ETDEWEB)

    Vinet, Luc [Centre de Recherches Mathematiques, Universite de Montreal, PO Box 6128, Centre-ville Station, Montreal, Quebec, H3C 3J7 (Canada); Zhedanov, Alexei, E-mail: zhedanov@fti.dn.ua [Donetsk Institute for Physics and Technology, Donetsk 83114 (Ukraine)

    2011-02-25

    We study a family of &apos;classical&apos; orthogonal polynomials which satisfy (apart from a three-term recurrence relation) an eigenvalue problem with a differential operator of Dunkl type. These polynomials can be obtained from the little q-Jacobi polynomials in the limit q = -1. We also show that these polynomials provide a nontrivial realization of the Askey-Wilson algebra for q = -1.

  6. The &apos;Instrumental&apos; Reality of Phlogiston

    OpenAIRE

    Mi Gyung Kim

    2008-01-01

    The stability of phlogiston in eighteenth-century French chemistry depended not on its role as a comprehensive theory, but on its operational (instrumental), theoretical, and philosophical (speculative) identities that were forged in different contexts, yet were interwoven to designate a single substance. It was as &apos;real&apos; as any other chemical substance to the degree that it was obtained through material operations, occupied a place in the theoretical edifice of the affinity table, ...

  7. [Ecclesia et civitatis : kościoł i życie religije w mieście średniowiecznym] / Raimo Pullat

    Index Scriptorium Estoniae

    Pullat, Raimo, 1935-

    2009-01-01

    Arvustus: Ecclesia et civitatis : kościoł i życie religije w mieście średniowiecznym. Pod redakcją Haliny Manikowskiej i Hanny Zaremskiej. Colloquia Mediaevalia Varsoviensia III. Warszawa : Instytut Historii PAN, 2002. Kollokviumi materjalide publikatsioonis käsitletakse peamiselt Sileesia, Preisimaa ja Pommeri linnu, mis käsitletaval perioodil kuulusid Poola koosseisu. Usuelu uurimise metodoloogiast.

  8. &apos;&apos;Life-cycle costs&apos;&apos; of industrial electric drives in the process industry - energy consumption and economics of electric drives

    Energy Technology Data Exchange (ETDEWEB)

    Bieniek, K. [BASF AG, Ludwigshafen (Germany)

    2000-07-01

    For electric motors in the process industry, the purchase price is only a small fraction of the overall &apos;&apos;life-cycle costs&apos;&apos;. The most important criteria are reliability, noise and efficiency. The engineering expense for assessing energy consumption must be kept in accordance to the saving potential. In the German chemical industry, reliability has attained an encouragingly high level thanks to applying the &apos;&apos;VIK recommendations&apos;&apos;. Standardised sizes (&apos;&apos;European standard motor&apos;&apos;) guarantee the interchangeability. That gives also a good basis for introducing improved motors, e.g. with less noise or with better efficiency. Today&apos;s market offers already a high level of efficiencies: Improvements will justify only small price increases. Despite their large number, small motors of less than 1 kW consume only a small percentage of the total electricity demand in a plant, and for large motors (above 100 kW) energy losses are already evaluated in detail. For the &apos;&apos;standard motors&apos;&apos; approximately between 1 and 100 kW, a standardised classification and labelling of the motor efficiencies will be a useful tool for selecting the optimal motors for their applications. To ensure interchangeability, the motor sizes and installation dimensions must remain unchanged. (orig.)

  9. Early changes in vascular reactivity in response to 56Fe irradiation in ApoE-/- mice

    Science.gov (United States)

    White, C. Roger; Yu, Tao; Gupta, Kiran; Babitz, Stephen K.; Black, Leland L.; Kabarowski, Janusz H.; Kucik, Dennis F.

    2015-03-01

    Epidemiological studies have established that radiation from a number of terrestrial sources increases the risk of atherosclerosis. The accelerated heavy ions in the galacto-cosmic radiation (GCR) that astronauts will encounter on in space, however, interact very differently with tissues than most types of terrestrial radiation, so the health consequences of exposure on deep-space missions are not clear. We demonstrated earlier that 56Fe, an important component of cosmic radiation, accelerates atherosclerotic plaque development. In the present study, we examined an earlier, pro-atherogenic event that might be predictive of later atherosclerotic disease. Decreased endothelium-dependent vasodilation is a prominent manifestation of vascular dysfunction that is thought to predispose humans to the development of structural vascular changes that precede the development of atherosclerotic plaques. To test the effect of heavy-ion radiation on endothelium-dependent vasodilation, we used the same ApoE-/- mouse model in which we previously demonstrated the pro-atherogenic effect of 56Fe on plaque development. Ten week old male ApoE mice (an age at which there is little atherosclerotic plaque in the descending aorta) were exposed to 2.6 Gy 56Fe. The mice were then fed a normal diet and housed under standard conditions. At 4-5 weeks post-irradiation, aortic rings were isolated and endothelial-dependent relaxation was measured. Relaxation in response to acetylcholine was significantly impaired in irradiated mice compared to age-matched, un-irradiated mice. This decrease in vascular reactivity following 56Fe irradiation occurred eight weeks prior to the development of statistically significant exacerbation of aortic plaque formation and may contribute to the formation of later atherosclerotic lesions.

  10. Folate targeted polymeric &apos;green&apos; nanotherapy for cancer

    Energy Technology Data Exchange (ETDEWEB)

    Narayanan, Sreeja; Binulal, N S; Mony, Ullas; Manzoor, Koyakutty; Nair, Shantikumar; Menon, Deepthy, E-mail: deepthymenon@aims.amrita.edu [Amrita Center for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi-682 041, Kerala (India)

    2010-07-16

    The concept of &apos;green&apos; chemotherapy by employing targeted nanoparticle mediated delivery to enhance the efficacy of phytomedicines is reported. Poly (lactide-co-glycolide) (PLGA) nanoparticles encapsulating a well known nutraceutical namely, grape seed extract (GSE)-&apos;NanoGSE&apos;-was prepared by a nanoprecipitation technique. The drug-loaded nanoparticles of size {approx} 100 nm exhibited high colloidal stability at physiological pH. Molecular receptor targeting of this nanophytomedicine against folate receptor over-expressing cancers was demonstrated in vitro by conjugation with a potential cancer targeting ligand, folic acid (FA). Fluorescence microscopy and flow cytometry data showed highly specific cellular uptake of FA conjugated NanoGSE on folate receptor positive cancer cells. Studies were also conducted to investigate the efficiency of targeted (FA conjugated) versus non-targeted (non-FA conjugated) nanoformulations in causing cancer cell death. The IC{sub 50} values were lowered by a factor of {approx} 3 for FA-NanoGSE compared to the free drug, indicating substantially enhanced bioavailability to the tumor cells, sparing the normal ones. Receptor targeting of FA-NanoGSE resulted in a significant increase in apoptotic index, which was also quantified by flow cytometry and fluorescence microscopy. This in vitro study provides a basis for the use of nanoparticle mediated delivery of anticancer nutraceuticals to enhance bioavailability and effectively target cancer by a &apos;green&apos; approach.

  11. Reversal of novelty-induced hyperlocomotion and hippocampal c-Fos expression in GluA1 knockout male mice by the mGluR2/3 agonist LY354740.

    Science.gov (United States)

    Procaccini, C; Maksimovic, M; Aitta-Aho, T; Korpi, E R; Linden, A-M

    2013-10-10

    Dysfunctional glutamatergic neurotransmission has been implicated in schizophrenia and mood disorders. As a putative model for these disorders, a mouse line lacking the GluA1 subunit (GluA1-KO) of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor displays a robust novelty-induced hyperlocomotion associated with excessive neuronal activation in the hippocampus. Agonists of metabotropic glutamate 2/3 receptors (mGluR2/3) inhibit glutamate release in various brain regions and they have been shown to inhibit neuronal activation in the hippocampus. Here, we tested a hypothesis that novelty-induced hyperlocomotion in the GluA1-KO mice is mediated via excessive hippocampal neuronal activation by analyzing whether an mGluR2/3 agonist inhibits this phenotypic feature. GluA1-KO mice and littermate wildtype (WT) controls were administered with (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740) (15 mg/kg, i.p.) 30 min before a 2-h exposure to novel arenas after which c-Fos immunopositive cells were analyzed in the hippocampus. LY354740 (15 mg/kg) decreased hyperactivity in male GluA1-KO mice, with only a minimal effect in WT controls. This was observed in two cohorts of animals, one naïve to handling and injections, another pre-handled and accustomed to injections. LY354740 (15 mg/kg) also reduced the excessive c-Fos expression in the dorsal hippocampal CA1 pyramidal cell layer in maleGluA1-KO mice, while not affecting c-Fos levels in WT mice. In female mice, no significant effect for LY354740 (15 mg/kg) on hyperactive behavior or hippocampal c-Fos was observed in either genotype or treatment cohort. A higher dose of LY354740 (30 mg/kg) alleviated hyperlocomotion of GluA1-KO males, but not that of GluA1-KO females. In conclusion, the excessive behavioral hyperactivity of GluA1-KO mice can be partly prevented by reducing neuronal excitability in the hippocampus with the mGluR2/3 agonist suggesting that the hippocampal

  12. ApoE4 induces synaptic and ERG impairments in the retina of young targeted replacement apoE4 mice.

    Directory of Open Access Journals (Sweden)

    Ran Antes

    Full Text Available The vertebrate retina, which is part of the central nervous system, is a window into the brain. The present study investigated the extent to which the retina can be used as a model for studying the pathological effects of apolipoprotein E4 (apoE4, the most prevalent genetic risk factor for Alzheimer's disease (AD. Immunohistochemical studies of retinas from young (4 months old apoE4-targeted replacement mice and from corresponding mice which express the AD benign apoE3 allele, revealed that the density of the perikarya of the different classes of retinal neurons was not affected by apoE4. In contrast, the synaptic density of the retinal synaptic layers, which was assessed immunohistochemically and by immunoblot experiments, was significantly lower in the apoE4 than in the apoE3 mice. This was associated with reduced levels of the presynaptic vesicular glutamatergic transporter, VGluT1, but not of either the GABAergic vesicular transporter, VGaT, or the cholinergic vesicular transporter, VAChT, suggesting that the glutamatergic nerve terminals are preferentially affected by apoE4. In contrast, the post synaptic scaffold proteins PSD-95 and Gephyrin, which reside in excitatory and inhibitory synapses, respectively, were both elevated, and their ratio was not affected by apoE4. Electroretinogram (ERG recordings revealed significant attenuation of mixed rod-cone responses in dark-adapted eyes of apoE4 mice. These findings suggest that the reduced ERG response in the apoE4 mice may be related to the observed decrease in the retinal nerve terminals and that the retina could be used as a novel model for non-invasive monitoring of the effects of apoE4 on the CNS.

  13. 活性生物KO菌在污水处理中的应用%Use of Active Biological KO Bacteria in Sewage Treatment

    Institute of Scientific and Technical Information of China (English)

    张原娟; 高荣

    2016-01-01

    由于600 kt/a醇氨项目各装置开、停车频繁,高浓度氨氮污水冲击SBR污水处理系统,导致污泥死亡、出水浑浊。为了保证处理后的污水合格排放,在SBR池内投加了KO多功能复合微生物制剂( KO菌)。小试结果表明,投加KO菌后,SBR池出水氨氮含量达标,且具有一定的耐高浓度氨氮冲击的效果。%Because of the frequent startup and shutdown of each equipment in the 600 kt/a methanol-ammonia plant, high concentration ammonia-nitrogen sewage impacts on SBR waste water treatment system, which leads to the death of bacteria in sludge and turbid effluent. In order to ensure discharge of qualified waste water after treatment, the KO multifunctional compound microbial preparation ( KO bacteria) is added to SBR pond. Laboratory scale test results show that after adding KO bacteria, the ammonia-nitrogen content of effluent of SBR pond meets requirements, and it has certain high concentration ammonia-nitrogen impact resistance effect.

  14. Transspecies Transmission of Gammaretroviruses and the Origin of the Gibbon Ape Leukaemia Virus (GaLV and the Koala Retrovirus (KoRV

    Directory of Open Access Journals (Sweden)

    Joachim Denner

    2016-12-01

    Full Text Available Transspecies transmission of retroviruses is a frequent event, and the human immunodeficiency virus-1 (HIV-1 is a well-known example. The gibbon ape leukaemia virus (GaLV and koala retrovirus (KoRV, two gammaretroviruses, are also the result of a transspecies transmission, however from a still unknown host. Related retroviruses have been found in Southeast Asian mice although the sequence similarity was limited. Viruses with a higher sequence homology were isolated from Melomys burtoni, the Australian and Indonesian grassland melomys. However, only the habitats of the koalas and the grassland melomys in Australia are overlapping, indicating that the melomys virus may not be the precursor of the GaLV. Viruses closely related to GaLV/KoRV were also detected in bats. Therefore, given the fact that the habitats of the gibbons in Thailand and the koalas in Australia are far away, and that bats are able to fly over long distances, the hypothesis that retroviruses of bats are the origin of GaLV and KoRV deserves consideration. Analysis of previous transspecies transmissions of retroviruses may help to evaluate the potential of transmission of related retroviruses in the future, e.g., that of porcine endogenous retroviruses (PERVs during xenotransplantation using pig cells, tissues or organs.

  15. Postprandial apoE isoform and conformational changes associated with VLDL lipolysis products modulate monocyte inflammation.

    Directory of Open Access Journals (Sweden)

    Laura J den Hartigh

    Full Text Available Postprandial hyperlipemia, characterized by increased circulating very low-density lipoproteins (VLDL and circulating lipopolysaccharide (LPS, has been proposed as a mechanism of vascular injury. Our goal was to examine the interactions between postprandial lipoproteins, LPS, and apoE3 and apoE4 on monocyte activation.We showed that apoE3 complexed to phospholipid vesicles attenuates LPS-induced THP-1 monocyte cytokine expression, while apoE4 increases expression. ELISA revealed that apoE3 binds to LPS with higher affinity than apoE4. Electron paramagnetic resonance (EPR spectroscopy of site-directed spin labels placed on specific amino acids of apoE3 showed that LPS interferes with conformational changes normally associated with lipid binding. Specifically, compared to apoE4, apoE bearing the E3-like R112→Ser mutation displays increased self association when exposed to LPS, consistent with a stronger apoE3-LPS interaction. Additionally, lipolysis of fasting VLDL from normal human donors attenuated LPS-induced TNFα secretion from monocytes to a greater extent than postprandial VLDL, an effect partially reversed by blocking apoE. This effect was reproduced using fasting VLDL lipolysis products from e3/e3 donors, but not from e4/e4 subjects, suggesting that apoE3 on fasting VLDL prevents LPS-induced inflammation more readily than apoE4.Postprandial apoE isoform and conformational changes associated with VLDL dramatically modulate vascular inflammation.

  16. Neutrino--gaseous &apos;'pancakes'&apos; in cosmology, and the missing-mass problem

    Energy Technology Data Exchange (ETDEWEB)

    Doroshkevich, A.G.

    1983-07-01

    If allowance is made for the random thermal velocities of the massive neutrinos, the density of the gaseous (baryon) component will dominate the neutrino density in the central part of a primordial &apos;'pancake'&apos; (rho/sub b/>rho/sub ..nu../), even though on the average rho-bar/sub b/<

  17. Computerized axial tomography of the chest for visualization of &apos;'absent'&apos; pulmonary arteries

    Energy Technology Data Exchange (ETDEWEB)

    Sondheimer, H.M. (Upstate Medical Center, Syracuse, NY); Oliphant, M.; Schneider, B.; Kavey, R.E.W.; Blackman, M.S.; Parker, F.B. Jr.

    1982-05-01

    To expand the search for central pulmonary arteries in six patients with absence of cardiac-pulmonary continuity, computerized axial tomography (CAT) of the chest was performed. The CAT scans were compared with previous arteriograms and pulmonary vein wedge angiograms. Three patients with type IV truncus arteriosus were studied, and none had a central, right or left pulmonary artery on CAT scan. However, two patients with tetralogy of Fallot with pulmonary atresia and a patent ductus arteriosus to the right lung demonstrated the presence of a left pulmonary artery. In addition, one child with truncus arteriosus with &apos;'absent'&apos; left pulmonary artery demonstrated a left pulmonary artery on the CAT scan. The CAT scan may therefore enhance our ability to search for disconnected pulmonary arteries in children with complex cyanotic congenital heart disease.

  18. Equation of &apos;'state'&apos; for thermoremanent magnetization in micron-size powders of copper oxide superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Shaw, G.; Agrawala, G.; Bhagat, S.M. (Dept. of Physics, Center for Superconductivity Research, Univ. of Maryland, College Park, MD (USA))

    1991-04-01

    We have extended previous studies on the time and temperature dependence of M{sub ZFC}, M{sub FC} and M{sub TRM} of Y{sub 1}Ba{sub 2}Cu{sub 3}O{sub 7} powders to encompass a variety of sizes and methods of preparation. The slow long term decays are confirmed over a wider time span. The T dependence of M{sub TRM} is well described by M{sub TRM}proportional to (1-(T/Tc)){sup q} and this &apos;&apos;equation of state&apos;&apos; is rendered plausible on the basis of a model involving thermally assisted escape of individual fluxons. (orig.).

  19. Comment on &apos;Note on Faraday&apos;s law and Maxwell&apos;s equations&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Redzic, Dragan V [Faculty of Physics, University of Belgrade, PO Box 368, 11001 Beograd (Yugoslavia)], E-mail: redzic@ff.bg.ac.yu

    2008-11-15

    We discuss some problematic contentions in a recent note on Faraday&apos;s law (Kholmetskii et al 2008 Eur. J. Phys. 29 N5-10). We also do justice to Hertz, Helmholtz and Maxwell. (letters and comments)

  20. &apos;&apos;{sup local}Renewables model communities network&apos;&apos;. An international initiative by ICLEI

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Emani [ICLEI South Asia Secretariat, Noida (India); Macedo, Laura Valente de [ICLEI Latin America and Caribbean Secretariat, Buenos Aires, DF (Argentina); Staden, Maryke van [ICLEI European Secretariat, Freiburg (Germany)

    2008-07-01

    Local governments (LGs) play a crucial role in implementing local energy policies, ensuring effective regulations, managing assets and providing a wide range of services that impact energy consumption. It is clear that they must also be key players in the transformation to sustainable energy in their communities. The &apos;&apos;{sup local}Renewables Model Communities Network&apos;&apos; (LR), an initiative of ICLEI - Local Governments for Sustainability, to build an international network of communities committed to sustainable energy. The participating cities and towns from developing and developed countries act as role models, and encourage others. LR network communities share information on aspects of sustainable energy, experiences and expertise, from policies to technologies, from stakeholder involvement to implementation processes. LGs around the globe have to become active in the field of sustainable energy. The also require support from various actors, including international cooperation and exchange to support their transition towards sustainable energy solutions. (orig.)

  1. Prospects for neutron star equation of state constraints using &apos;'recycled'&apos; millisecond pulsars

    Energy Technology Data Exchange (ETDEWEB)

    Bogdanov, Slavko [Columbia University, Columbia Astrophysics Laboratory, New York, NY (United States)

    2016-02-15

    &apos;'Recycled'&apos; millisecond pulsars are a variety of rapidly spinning neutron stars that typically show thermal X-ray radiation due to the heated surface of their magnetic polar caps. Detailed numerical modeling of the rotation-induced thermal X-ray pulsations observed from recycled millisecond pulsars, including all relevant relativistic and stellar atmospheric effects, has been identified as a promising approach towards an astrophysical determination of the true neutron star mass-radius relation, and by extension the state of cold matter at densities exceeding those of atomic nuclei. Herein, I review the basic model and methodology commonly used to extract information regarding neutron star structure from the pulsed X-ray radiation observed from millisecond pulsars. I also summarize the results of past X-ray observations of these objects and the prospects for precision neutron star mass-radius measurements with the upcoming Neutron Star Interior Composition Explorer (NICER) X-ray timing mission. (orig.)

  2. Quantum dynamics via Planck-scale-stepped action-carrying &apos;Graph Paths&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Chew, Geoffrey F.

    2003-05-05

    A divergence-free, parameter-free, path-based discrete-time quantum dynamics is designed to not only enlarge the achievements of general relativity and the standard particle model, by approximations at spacetime scales far above Planck scale while far below Hubble scale, but to allow tackling of hitherto inaccessible questions. &apos;&apos;Path space&apos;&apos; is larger than and precursor to Hilbert-space basis. The wave-function-propagating paths are action-carrying structured graphs-cubic and quartic structured vertices connected by structured &apos;'fermionic'&apos; or &apos;'bosonic'&apos; &apos;'particle'&apos; and &apos;'nonparticle'&apos; arcs. A Planck-scale path step determines the gravitational constant while controlling all graph structure. The basis of the theory&apos;s (zero-rest-mass) elementary-particle Hilbert space (which includes neither gravitons nor scalar bosons) resides in particle arcs. Nonparticle arcs within a path are responsible for energy and rest mass.

  3. Hawai&apos;i&apos;s EVolution: Hawai&apos;i Powered. Technology Driven. (Brochure)

    Energy Technology Data Exchange (ETDEWEB)

    2013-05-01

    This Hawaii Clean Energy Initiative (HCEI) brochure outlines Hawaii&apos;s energy and transportation goals and the implementation of electric vehicles (EV) and electric vehicle infrastructure since HCEI began in 2008. It includes information about Hawaii&apos;s role in leading the nation in available EV charging infrastructure per capita; challenges for continuing to implement EV technology; features on various successful EV users, including the Hawaiian Electric Company, Enterprise Rent-A-Car, and Senator Mike Gabbard; how EVs can integrate into and help propel Hawaii&apos;s evolving smart grid; and much more.

  4. Deep-sea drilling. Practical aspects of 4D seismic: what an engineer needs to know. Developments in Iran: &apos;SIRRI&apos; of the Total company and &apos;DOROOD&apos; of the Elf company. The &apos;DOROOD&apos; operating plan. The &apos;SIRRI&apos; operating plan; Le forage en eau profonde. Aspects pratiques de la sismique 4D: ce qu&apos;un ingenieur doit savoir. Developpements en Iran: &apos;SIRRI&apos; de Total et &apos;DOROOD&apos; d&apos;Elf. Le projet &apos;DOROOD&apos;. Le projet &apos;SIRRI&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Claverie, P. [Schlumberger Sedco Forex, 92 - Montrouge (France); Bauquis, P.R. [Association Francaise des Techniciens et Professionnels du Petrole, AFTP, 92 - Paris-la-Defense (France); Seiller, B.; Geronimi, X. [Elf France, (France); Barthe, D. [Total Fina, 92 - La Defense (France)

    1999-08-01

    In this &apos;Drilling-Production&apos; section, in which 7 papers are gathered, 3 main topics are developed: (1)the deep-sea drilling (2)the practical aspects of 4D seismic (3)the &apos;SIRRI&apos; and &apos;DOROOD&apos; operating plans in Iran. Concerning the first point, it can be noticed that nowadays, mobile platforms are located in great offshore where water depths are of about 2400 m. In the second point is particularly detailed what 4D is, what it can do, what the primary conditions for it works are and how it costs. The third point is the more particularly detailed in this section (15 pages). At first an introduction indicates why Iran has to call to international petroleum investors, what the current problems of Iran are, what Iran has to do to attract foreign investment and technology and what the challenges to foreign companies are. Then the two operating plans: &apos;SIRRI&apos; and &apos;DOROOD&apos; are exposed into details. A synthesis of these plans, called of &apos;Buy Back&apos;, (production, investment, refund) is given as well as their advantages and disadvantages. (O.M.)

  5. Retro-odontoid &apos;'ghost'&apos; pseudotumours in atlanto-axial instability caused by rheumatoid arthritis

    Energy Technology Data Exchange (ETDEWEB)

    Kenez, J. (Dept. of Neurology, Semmelweis Medical Univ., Budapest (Hungary)); Turoczy, L. (Dept. of Neurosurgery, National Inst. of Traumatology, Budapest (Hungary)); Barsi, P. (Dept. of Neurology, Semmelweis Medical Univ., Budapest (Hungary)); Veres, R. (Dept. of Neurosurgery, National Inst. of Traumatology, Budapest (Hungary))

    1993-05-01

    Among 27 cases of marked atlanto-axial instability investigated in the last 10 years we found three with reducible dislocation, in which a cystic &apos;ghost&apos; pseudo-tumours appeared behind the odontoid, maintaining cord compression even in the reduced position, thus influencing the strategy of operative treatment. The cervical spine and the craniocervical region were examined by conventional tomogrpaphy, myelotomography, CT, CT myelography (following melography), and recently in some cases with MRI. (orig./UWA)

  6. Continuous process of powder production for MOX fuel fabrication according to &apos;'granat'&apos; technology

    Energy Technology Data Exchange (ETDEWEB)

    Morkovnikov, V.E.; Raginskiy, L.S.; Pavlinov, A.P.; Chernov, V.A.; Revyakin, V.V.; Varykhanov, V.S.; Revnov, V.N. [SSC RF, A.A. Bochvar All-Russia, Research Institute of Inorganic Materials, VNIINM (Russian Federation)

    2000-07-01

    During last years the problem of commercial MOX fuel fabrication for nuclear reactors in Russia was solved in a number of directions. The paper deals with the solution of the problem of creating a continuous pilot plant for the production of MOX fuel powders on the basis of the home technology &apos;Granat&apos;, that was tested before on a small-scale pilot-commercial batch-operated plant of the same name and confirmed good results. (authors)

  7. Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment.

    Science.gov (United States)

    Salomon-Zimri, Shiran; Glat, Micaela Johanna; Barhum, Yael; Luz, Ishai; Boehm-Cagan, Anat; Liraz, Ori; Ben-Zur, Tali; Offen, Daniel; Michaelson, Daniel M

    2016-06-30

    Apolipoprotein E4 (ApoE4), the most prevalent genetic risk factor for Alzheimer's disease (AD), is associated with increased neurodegeneration and vascular impairments. Vascular endothelial growth factor (VEGF), originally described as a key angiogenic factor, has recently been shown to play a crucial role in the nervous system. The objective of this research is to examine the role of VEGF in mediating the apoE4-driven pathologies. We show that hippocampal VEGF levels are lower in apoE4 targeted replacement mice compared to the corresponding apoE3 mice. This effect was accompanied by a specific decrease in both VEGF receptor-2 and HIF1-α. We next set to examine whether upregulation of VEGF can reverse apoE4-driven pathologies, namely the accumulation of hyperphosphorylated tau (AT8) and Aβ42, and reduced levels of the pre-synaptic marker, VGluT1, and of the ApoE receptor, ApoER2. This was first performed utilizing intra-hippocampal injection of VEGF-expressing-lentivirus (LV-VEGF). This revealed that LV-VEGF treatment reversed the apoE4-driven cognitive deficits and synaptic pathologies. The levels of Aβ42 and AT8, however, were increased in apoE3 mice, masking any potential effects of this treatment on the apoE4 mice. Follow-up experiments utilizing VEGF-expressing adeno-associated-virus (AAV-VEGF), which expresses VEGF specifically under the GFAP astrocytic promoter, prevented this effects on apoE3 mice, and reversed the apoE4-related increase in Aβ42 and AT8. Taken together, these results suggest that apoE4-driven pathologies are mediated by a VEGF-dependent pathway, resulting in cognitive impairments and brain pathology. These animal model findings suggest that the VEGF system is a promising target for the treatment of apoE4 carriers in AD.

  8. International Conference on the Conservation of the Lesser Spotted Eagle, Košická Belá, Slovakia, 2014

    Directory of Open Access Journals (Sweden)

    Guziová Zuzana

    2015-06-01

    Full Text Available Medzinárodná konferencia o ochrane orla kriklavého (Aquila pomarina sa konala 25. - 27. septembra 2014 v Penzióne Lesanka v Košickej Belej na Slovensku. Zorganizovala ju Ochrana dravcov na Slovensku (RPS v spolupráci s Východoslovenskou energetikou Holding a.s. Konferencia bola zameraná na prípravu podkladov pre aktualizáciu európskeho akcného plánu pre orla kriklavého, zdielanie informácií o biológii a ekológia druhu a na výmenu skúseností s osvedcenými alebo inovatívnymi opatreniami pre zachovanie orla kriklavého. Konferencie sa zúcastnilo celkom 59 úcastníkov zo 14 krajín. Na konferencii odznelo 17 príspevkov a bolo prezentovaných 7 posterov. Niektoré z týchto príspevkov sú publikované v casopise Slovak Raptor Journal 9 (2015, dalších 23 príspevkov sú publikované formou konferencných abstraktov. Program konferencie zahrnal aj 2 exkurzie, pocas ktorých mali úcastníci možnost vidiet ukážku inštalácie konzolových chrániciek na stlpoch 22 kV elektrického vedenia a typické biotopy orla kriklavého. Konferencia bola organizovaná v rámci projektu LIFE09NAT/SK/000396 Ochrana orla kriklavého na Slovensku, ktorý realizovala Ochrana dravcov na Slovensku, Východoslovenská energetika Holding a.s., Stredoslovenská energetika, a.s. a Stredoslovenská energetika-Distribúcia, a.s. Projekt bol spolufinancovaný Európskou úniou prostredníctvom financného nástroja LIFE a Ministerstvom životného prostredia Slovenskej republiky.

  9. THE TYPOLOGY OF THE AGRICULTURAL LANDSCAPE OF DUBROVAČKO PRIMORJE AS A BASIS FOR DIRECTING DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Ines Hrdalo

    2008-07-01

    Full Text Available Abandonment of rural areas in Dubrovačko Primorje in the last 50 years resulted with changes of its spatial characteristics and identity. This process defi ned this place as a virtually derelict area. The main goal of this work is to determine landscape types based upon survey and spatial analyses. They can be helpful in a process of determination of spatial qualities. Landscape division was made according to the natural and anthropogenic features of this area. Therefore, landscape was divided on natural (coast, karst terrain and landscapes of the macchia and cultural (settlement and agriculture landscapes. Working methods consisted of several research stages. The fi rst stage comprised a review of relevant literature concerning natural and sociological features of the explored area. Working methods of prof. dr. Marušič were inspiration for evolvement of this research [16]. The next stage of research was the fi eld work by means of observation method which resulted in detailed photo documentation, showing different types of the agricultural landscapes. Indoor work consisted of the orthophoto production, which was a base for further exploration. Consequently, detailed map of the land use, as well as an agricultural map of the area was made according to the structural husbandry character. Digital mapping of the thematical maps in GIS – Arc View software program, produced a database of social and natural elements of the area. Overlapping of all these maps helped in determination of causal processes. Comparison of these outcomes with terrain photo documentation led to the research results and fi nal conclusions. This research showed interesting structural features of agricultural landscapes. Its division was made according to its form which emerged from the land use and its natural character. Consequently, agricultural landscapes are divided into fi elds (with regular parcels and those with irregular land division, dry stone walls with organic

  10. What does the APO mean?

    Directory of Open Access Journals (Sweden)

    Yafei Wang

    2016-10-01

    Full Text Available The Asian–Pacific Oscillation (APO is a relatively new teleconnection index and a number of peer-reviewed studies have confirmed its’ existence. This study reexamines the concept of the APO teleconnection as currently published in the literature. Most results have found that this pattern could be defined as its own teleconnection pattern within the Pacific Ocean Basin. This work demonstrates that the APO is inevitably associated with an additional action centre located over the North Atlantic Ocean, and the index can be extended. Previous studies have used a variety of methods to represent the APO, and a method is proposed here to standardise the formulation. It is argued that the extended index proposed here provides a more robust result. The APO typically is identified using the eddy temperature rather than geopotential height as the source material for its construction, as geopotential could not adequately represent this teleconnection pattern. This leads to a discussion regarding the basic criterion for defining teleconnective activity within the extratropical regions. We also identify other problems in the current understanding of APO theory that need to be addressed.

  11. Keanakākoʻi Tephra produced by 300 years of explosive eruptions following collapse of Kīlauea's caldera in about 1500 CE

    Science.gov (United States)

    Swanson, Donald A.; Rose, Timothy R.; Fiske, Richard S.; McGeehin, John P.

    2012-01-01

    The Keanakākoʻi Tephra at Kīlauea Volcano has previously been interpreted by some as the product of a caldera-forming eruption in 1790 CE. Our study, however, finds stratigraphic and 14C evidence that the tephra instead results from numerous eruptions throughout a 300-year period between about 1500 and 1800. The stratigraphic evidence includes: (1) as many as six pure lithic ash beds interleaved in sand dunes made of earlier Keanakākoʻi vitric ash, (2) three lava flows from Kīlauea and Mauna Loa interbedded with the tephra, (3) buried syneruptive cultural structures, (4) numerous intraformational water-cut gullies, and (5) abundant organic layers rich in charcoal within the tephra section. Interpretation of 97 new accelerator mass spectrometry (AMS) 14C ages and 4 previous conventional ages suggests that explosive eruptions began in 1470–1510 CE, and that explosive activity continued episodically until the early 1800s, probably with two periods of quiescence lasting several decades. Kīlauea's caldera, rather than forming in 1790, predates the first eruption of the Keanakākoʻi and collapsed in 1470–1510, immediately following, and perhaps causing, the end of the 60-year-long, 4–6 km3 ʻAilāʻau eruption from the east side of Kīlauea's summit area. The caldera was several hundred meters deep when the Keanakākoʻi began erupting, consistent with oral tradition, and probably had a volume of 4–6 km3. The caldera formed by collapse, but no eruption of lava coincided with its formation. A large volume of magma may have quickly drained from the summit reservoir and intruded into the east rift zone, perhaps in response to a major south-flank slip event, leading to summit collapse. Alternatively, magma may have slowly drained from the reservoir during the prolonged ʻAilāʻau eruption, causing episodic collapses before the final, largest downdrop took place. Two prolonged periods of episodic explosive eruptions are known at Kīlauea, the Keanakāko

  12. Limnothrix sp. KO05: A newly characterized cyanobacterial biosorbent for cadmium removal: the enzymatic and non-enzymatic antioxidant reactions to cadmium toxicity.

    Science.gov (United States)

    Haghighi, Omid; Shahryari, Shahab; Ebadi, Mojgan; Modiri, Sima; Zahiri, Hossein Shahbani; Maleki, Hadi; Noghabi, Kambiz Akbari

    2017-03-18

    In this study, we isolated five indigenous cyanobacterial strains from different aqueous environments, with heavy metals contamination, in East Azerbaijan Province (northwest portion of Iran). A strain was identified by morphological and 16S rRNA sequence analysis as Limnothrix sp. KO05 and selected for further studies as having the greatest potential for cadmium uptake. Scanning electron microscopy (SEM) demonstrated cyanobacterium Limnothrix sp. KO05 forms filamentous structures and is straight or curved to some extent. The utmost biosorption capacity was found to be 82.18±1.22mgg(-1) at a Cd (II) concentration level of 150mgL(-1). Langmuir adsorption isotherm indicated a better fit to the experimental data. Response surface methodology (RSM) on the basis of four independent variables and the predicted maximum biosorption efficiency was 98.7% under the optimum condition. FT-IR spectroscopy profile of the Cd treated sample as demonstrated in confirmation of the benefits of various functional groups of proteins and polysaccharides of cyanobacterial biomass, involved in surface binding of Cd. The determination of catalase (CAT) activity in strain KO05 exposed to Cd (II) concentrations of 2, 5 and 10mgL(-1) showed an increase in enzyme activity after 24h exposure compared to unexposed cells. Correspondingly, CAT activity showed a significant decrease after 48h of treatment with Cd (II) concentrations of 5 and 10mgL(-1). CAT activity was decreased significantly at all concentrations within 72h after exposure to Cd. On the contrary, while ascorbate peroxidase (APX) gave the expected lower activity compared to the CAT within 24h after Cd treatment, its activity lasted up to 72h. Limnothrix sp. KO05 cells treated with 5 and 10mgL(-1) Cd (II) over 72h exposure showed a reduction in chlorophyll a contents compared to the controls. However, following exposure to Cd, chlorophyll a and carotenoid contents is reduced and after overcoming stress and deployment of an adaptation

  13. Calculation of LDL apoB

    NARCIS (Netherlands)

    Sniderman, A.D.; Tremblay, A.J.; Graaf, J. de; Couture, P.

    2014-01-01

    OBJECTIVES: This study tests the validity of the Hattori formula to calculate LDL apoB based on plasma lipids and total apoB. METHODS: In 2178 patients in a tertiary care lipid clinic, LDL apoB calculated as suggested by Hattori et al. was compared to directly measured LDL apoB isolated by ultracent

  14. smesh User&apos;s Guide

    Energy Technology Data Exchange (ETDEWEB)

    Chand, K K

    2003-05-05

    &apos;'smesh'&apos; is a general purpose, interactive, 2D unstructured mesh generator based on Overture. It supports three kinds of mesh generation techniques: structured patches with transfinite interpolation (TFI); unstructured triangles based on an advancing front technique; and a Cartesian cutcell/triangle hybrid method. Meshes are generated in a generalized &apos;'multi-block'&apos; manner where each &apos;'block'&apos;, or region, can be one of the three mesh types. Geometry definitions can be created interactively by placing points and interpolating curves. Spacing information is provided by both the curve discretization (which can be stretched) and a user specified preferred grid spacing for a region. A mesh optimization procedure is available for the non-TFI regions for mesh quality improvement. Each mesh region is given an unique identifier and an optional string name. Meshes are exported to a modified &apos;'ingrid'&apos; format including mesh region identifiers and names. Facilities for command scripting and batch running are available.

  15. Performance of &apos;'ductless'&apos; personalized ventilation in conjunction with displacement ventilation: Impact of disturbances due to walking person(s)

    Energy Technology Data Exchange (ETDEWEB)

    Halvonova, Barbora [Department of Building Services, Slovak University of Technology in Bratislava, 813 68 Bratislava (Slovakia); International Centre for Indoor Environment and Energy, Department of Civil Engineering, Technical University of Denmark (Denmark); Melikov, Arsen K. [International Centre for Indoor Environment and Energy, Department of Civil Engineering, Technical University of Denmark (Denmark)

    2010-02-15

    The performance of the novel &apos;'ductless'&apos; personalized ventilation in conjunction with displacement ventilation (DV) was compared with the performance of DV alone under realistic conditions involving disturbances due to walking of one or two persons. An office room with two workstations was arranged in a full-scale test room. Two thermal manikins were used as sedentary occupants at the workstations. Two pollution sources, namely exhaled air by one of the manikins and passive pollution on the table in front of the same manikin were simulated. The performance of the ventilation systems was evaluated with regard to the quality of inhaled air and thermal comfort of the seated &apos;'occupants'&apos;. The walking person(s) caused mixing of the clean and cool air near the floor with the polluted and warmer air at higher levels and disturbed the displacement principle which resulted in a decrease of the inhaled air quality. The performance of the &apos;'ductless'&apos; PV under the tested conditions was better as opposed to DV alone. Thus in practice the &apos;'ductless'&apos; PV will be superior to DV alone as regards perceived quality of inhaled air. The location of a walking person was found to be important. Person(s) walking close to the displacement diffuser will cause greater disturbance. (author)

  16. Supporting Black Male Community College Success: Determinants of Faculty-Student Engagement

    Science.gov (United States)

    Wood, J. Luke; Ireland, S. Mei-Yen

    2014-01-01

    The purpose of this study was to examine determinants of Black male students&apos; engagement with faculty in the community college. Data from this study were derived from the 2011 three-year cohort of the Community College Survey of Student Engagement (CCSSE). Using data from 11,384 Black male respondents within 260 community colleges, this study…

  17. Effect of AVE 0991 angiotensin-(1-7) receptor agonist treatment on elemental and biomolecular content and distribution in atherosclerotic plaques of apoE-knockout mice

    Science.gov (United States)

    Kowalska, J.; Gajda, M.; Jawień, J.; Kwiatek, W. M.; Appel, K.; Dumas, P.

    2013-12-01

    Gene-targeted apolipoprotein E-knockout (apoE-KO) mice display early and highly progressive vascular lesions containing lipid deposits and they became a reliable animal model to study atherosclerosis. The aim of the present study was to investigate the effect of AVE 0991 angiotensin-(1-7) receptor agonist on the distribution of selected pro- and anti- inflammatory elements as well as biomolecules in atherosclerotic plaques of apoE-knockout mice. Synchrotron radiation-based X-ray fluorescence (micro-XRF) and Fourier Transform Infrared (micro-FTIR) microspectroscopies were applied. Two-month-old apoE-KO mice were fed for following four months diet supplemented with AVE 0991 (0.58 μmol/kg b.w. per day). Histological sections of ascending aortas were analyzed spectroscopically. The distribution of P, Ca, Fe and Zn were found to correspond with histological structure of the lesion. Significantly lower contents of P, Ca, Zn and significantly higher content of Fe were observed in animals treated with AVE 0991. Biomolecular analysis showed lower lipids saturation level and lower lipid to protein ratio in AVE 0991 treated group. Protein secondary structure was studied according to the composition of amide I band (1660 cm-1) and it demonstrated higher proportion of β-sheet structure as compared to α-helix in both studied groups.

  18. The generation and function of soluble apoE receptors in the CNS

    Directory of Open Access Journals (Sweden)

    Rebeck G William

    2006-10-01

    Full Text Available Abstract More than a decade has passed since apolipoprotein E4 (APOE-ε4 was identified as a primary risk factor for Alzheimer 's disease (AD, yet researchers are even now struggling to understand how the apolipoprotein system integrates into the puzzle of AD etiology. The specific pathological actions of apoE4, methods of modulating apolipoprotein E4-associated risk, and possible roles of apoE in normal synaptic function are still being debated. These critical questions will never be fully answered without a complete understanding of the life cycle of the apolipoprotein receptors that mediate the uptake, signaling, and degradation of apoE. The present review will focus on apoE receptors as modulators of apoE actions and, in particular, explore the functions of soluble apoE receptors, a field almost entirely overlooked until now.

  19. Apolipoprotein E receptor-2 (ApoER2) mediates selenium uptake from selenoprotein P by the mouse testis.

    Science.gov (United States)

    Olson, Gary E; Winfrey, Virginia P; Nagdas, Subir K; Hill, Kristina E; Burk, Raymond F

    2007-04-20

    Selenium is a micronutrient that is essential for the production of normal spermatozoa. The selenium-rich plasma protein selenoprotein P (Sepp1) is required for maintenance of testis selenium and for fertility of the male mouse. Sepp1 trafficking in the seminiferous epithelium was studied using conventional methods and mice with gene deletions. Immunocytochemistry demonstrated that Sepp1 is present in vesicle-like structures in the basal region of Sertoli cells, suggesting that the protein is taken up intact. Sepp1 affinity chromatography of a testicular extract followed by mass spectrometry-based identification of bound proteins identified apolipoprotein E receptor 2 (ApoER2) as a candidate testis Sepp1 receptor. In situ hybridization analysis identified Sertoli cells as the only cell type in the seminiferous epithelium with detectable ApoER2 expression. Testis selenium levels in apoER2(-/-) males were sharply reduced from those in apoER2(+/+) males and were comparable with the depressed levels found in Sepp1(-/-) males. However, liver selenium levels were unchanged by deletion of apoER2. Immunocytochemistry did not detect Sepp1 in the Sertoli cells of apoER2(-/-) males, consistent with a defect in the receptor-mediated Sepp1 uptake pathway. Phase contrast microscopy revealed identical sperm defects in apoER2(-/-) and Sepp1(-/-) mice. Co-immunoprecipitation analysis demonstrated an interaction of testis ApoER2 with Sepp1. These data demonstrate that Sertoli cell ApoER2 is a Sepp1 receptor and a component of the selenium delivery pathway to spermatogenic cells.

  20. The synchro crusher: a new type of impact?; Le &apos;'synchro-concasseur'&apos;: du nouveau dans l&apos;impact?

    Energy Technology Data Exchange (ETDEWEB)

    Van der Zanden, H.; Valenchon, P.

    1999-10-01

    The seminar organized by &apos;Quarry Management&apos; on the occasion of the Hillhead 99 workshop provided the Dutch company VanderZanden with the opportunity to present its research work on the development of a new concept of crushing called &apos;SynchroCrusher&apos;. Its principle uses the &apos;relative movement&apos; linked with &apos;synchronization&apos;. Each particle is uniformly and precisely crushed by a double impact, the second impact being only generated by the residual (free) energy and occurring at a greater speed. An optimal direct impact is obtained thanks to a perfect control of the impact angle (between 75 and 85 deg.) and of the particle trajectories with no interference between particles. This system allows to reduce both the energy consumption and the wear of crushers. This paper presents the concept of the SynchroCrusher, its comparison with other classical impact crushers and the R and D work carried out to analyze the movement of particles, the capacity of the crusher with respect to the orientation of blades, the directional changes of particles inside the crusher and the synchronization of particle trajectories. (J.S.)

  1. Ethanolic fermentation of sucrose, sugarcane juice and molasses by Escherichia coli strain ko11 and Klebsiella oxytoca strain P2 Fermentação etanólica de sacarose, caldo de cana-de-açúcar e de melaço por Escherichia coli KO11 e Klebsiella oxytoca P2

    Directory of Open Access Journals (Sweden)

    Gervásio P. da Silva

    2005-12-01

    Full Text Available Escherichia coli KO11 and Klebsiella oxytoca P2 recombinants fermented sucrose to ethanol. In minimal medium with 2% or 12% added sucrose KO11 produced 75% and 41%, respectively, of the maximum theoretical yield (0.54g ethanol/g sucrose. In Luria-Bertani (LB broth with up to 8% sucrose, KO11 presented a 94-96% yield and with 12% sucrose, KO11 presented about 69% yield (44.5g ethanol/L. P2 presented 55% of the theoretical maximum yield in minimal medium supplemented with 2% sucrose and 47% of the maximum in 12% sucrose. In LB broth with 2 or 4% sucrose, P2 presented 94-95% of the theoretical maximum yield, which fell to 73% with 8% added sucrose (31.4g ethanol/L and 58% with 12% sucrose (37.5 g/L. Volumetric productivity in LB broth containing 2% sucrose was 0.41 g/L/h for KO11 and 1.1 g/L/h for P2, while in LB broth with 12% added sucrose, productivity was 0.96 g/L/h (KO11 and 1.4 g/L/h (P2. During fermentation of sugar cane juice by E. coli KO11 and K. oxytoca P2 produced 39.4 g/L and 42.1 g/L ethanol when supplemented with 0.5% yeast extract, micronutrients and thiamine. In sugar cane juice supplemented with LB broth ingredients, KO11 ethanol fermentation was inhibited with production of only 23.0 g ethanol/L, while P2 produced 44.2 g/L. Ethanol production by KO11 and P2, respectively, in sugarcane juice was a 25.3 and 30.2 g/L with 0.2% ammonium sulfate, b 24.9 and 31.6 g/L with ammonium sulfate and micronutrients, c 25.6 and 37.5 g/L with ammonium sulfate, micronutrients and thiamine. During molasses fermentation E. coli KO11 presented low ethanol production and high lactic acid production. K. oxytoca P2 produced 25 g ethanol/L in molasses diluted 10-fold in water, with or without addition of 0.5% yeast extract, and 27.8 g/L with addition of LB broth ingredients after 96h. P2 produced 24.5, 26.9, and 28.0 g ethanol/L in molasses diluted 10-fold in vinasse, vinasse with 0.5% added yeast extract and with LB broth ingredients, respectively

  2. Why Germany&apos;s &apos;Messy&apos; energy transition should be a lesson to other nations

    Energy Technology Data Exchange (ETDEWEB)

    Shepherd, John [nuclear 24, Brighton (United Kingdom)

    2015-03-15

    Germany&apos;s so-called &apos;&apos;energy transition&apos;&apos; (&apos;'Energiewende'&apos;) is increasingly drawing the intention of the international community - but it seems for all the wrong reasons. US Senator Lamar Alexander said recently that German energy policy is one of the reasons the US should not abandon nuclear, but actually encourage increased investment in nuclear power plants. Alexander&apos;s remarks were made in an article published by the US Nuclear Energy Institute, in which he outlined his reasons why the US should not follow Germany&apos;s lead. Alexander rightly pointed out that the cost of attempting to replace nuclear power with wind, solar, and accompanying infrastructure is estimated by the German government at some 1.2 trillion US dollars (about 1 trillion Euros). The senator also made the point that Germany &apos;&apos;does not produce enough reliable, baseload energy for an important manufacturing economy&apos;&apos;. He also expressed concern at Germany&apos;s reliance on buying natural gas from Russia. While Germany has been forcing the closure of nuclear power plants others, including the oil-rich United Arab Emirates (UAE), have been investing in new nuclear, Alexander said. Judging from Alexander&apos;s remarks, it seems that Germany&apos;s energy transition experience will, after all, have a long-lasting legacy. That legacy will be a valuable lesson to other major industrialised nations in why they should not follow Germany&apos;s lead in abandoning a sensible energy mix, if they wish to maintain and develop economic and industrial productivity while keeping to international commitments to tackle climate change.

  3. A Survey of Open Clusters in the u&apos;g'r'i'z&apos; Filter System. 3. Results for the Cluster NGC 188

    Energy Technology Data Exchange (ETDEWEB)

    Fornal, Bartosz; Tucker, Douglas L.; Smith, J.Allyn; Allam, Sahar S.; Rider, Cristin J.; Sung, Hwankyung; /Jagiellonian U. /Fermilab /Austin Peay State U. /Wyoming U. /Johns Hopkins U. /Sejong U.

    2006-11-01

    The authors continue the series of papers describing the results of a photometric survey of open star clusters, primarily in the southern hemisphere, taken in the u&apos;g'r'i'z&apos; filter system. The entire observed sample covered more than 100 clusters, but here they present data only on NGC 188, which is one of the oldest open clusters known in the Milky Way. They fit the Padova theoretical isochrones to the data. Assuming a solar metallicity for NGC 188, they find a distance of 1700 {+-} 100 pc, an age of 7.5 {+-} 0.7 Gyr, and a reddening E(B-V) of 0.025 {+-} 0.005. This yields a distance modulus of 11.23 {+-} 0.14.

  4. Energy and the new class. [Assault of &apos;&apos;new breed&apos;&apos; of American on established institutions

    Energy Technology Data Exchange (ETDEWEB)

    King, L.

    1979-03-14

    The bounty of the US is taken for granted by its population. Nowhere is this misvaluation of a society and its benefits more evident than in the energy industries. But energy represents a tool by which society can be shaped; a device by which the standared of living and the very nature of the national lifestyle can be controlled, modified, amplified, or reduced. Two examples examined to show how energy shapes social order and human life are the women&apos;s movement and the desire to live in the Sunbelt. Five phenomena are then examined to point out the desire to restrain the nation&apos;s rampant pursuit of a higher standard of living, as opposed to the more subjective and seemingly more desirable goal of a better quality of life: the civil rights movement; the environmental movement; the Vietnam War; the Watergate scandal; and the assumption that prosperity at today&apos;s level is irreducible, concrete, and not subject to diminution. The &apos;&apos;new class&apos;&apos; is essentially made up of those educated in the liberal arts, divorced from an understanding of the mechanics of free-enterprise institutions and of the sicences. The antagonistic view of the new class of corporations and its assault on established institutions are noted. Energy companies are frustrated in telling their story, but the story that must be told is not the story of how excellently the energy sector has performed, but the story of how a new breed of Americans is seeking to remake America in its own image without the rest being aware of what is going on. (MCW)

  5. Imaging male breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Doyle, S., E-mail: sdoyle2@nhs.net [Primrose Breast Care Unit, Derriford Hospital, Plymouth (United Kingdom); Steel, J.; Porter, G. [Primrose Breast Care Unit, Derriford Hospital, Plymouth (United Kingdom)

    2011-11-15

    Male breast cancer is rare, with some pathological and radiological differences from female breast cancer. There is less familiarity with the imaging appearances of male breast cancer, due to its rarity and the more variable use of preoperative imaging. This review will illustrate the commonest imaging appearances of male breast cancer, with emphasis on differences from female breast cancer and potential pitfalls in diagnosis, based on a 10 year experience in our institution.

  6. The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice.

    Directory of Open Access Journals (Sweden)

    Carola I F Janssen

    Full Text Available Apolipoprotein E4 (ApoE4, one of three common isoforms of ApoE, is a major risk factor for late-onset Alzheimer disease (AD. ApoE-deficient mice, as well as mice expressing human ApoE4, display impaired learning and memory functions and signs of neurodegeneration. Moreover, ApoE protects against high-fat (HF diet induced neurodegeneration by its role in the maintenance of the integrity of the blood-brain barrier. The influence of a HF diet on the progression of AD-like cognitive and neuropathological changes was assessed in wild-type (WT, human ApoE4 and ApoE-knockout (ApoE-/- mice to evaluate the modulatory role of ApoE in this process. From 12 months of age, female WT, ApoE4, and ApoE-/- mice were fed either a standard or a HF diet (19% butter, 0.5% cholate, 1.25% cholesterol throughout life. At 15 months of age mice performed the Morris water maze, evaluating spatial learning and memory. ApoE-/- showed increased spatial learning compared to WT mice (p = 0.009. HF diet improved spatial learning in WT mice (p = 0.045, but did not affect ApoE4 and ApoE-/- mice. Immunohistochemical analyses of the hippocampus demonstrated increased neuroinflammation (CD68 in the cornu ammonis 1 (CA1 region in ApoE4 (p = 0.001 and in ApoE-/- (p = 0.032 mice on standard diet. HF diet tended to increase CD68 in the CA1 in WT mice (p = 0.052, while it decreased in ApoE4 (p = 0.009, but ApoE-/- remained unaffected. A trend towards increased neurogenesis (DCX was found in both ApoE4 (p = 0.052 and ApoE-/- mice (p = 0.068. In conclusion, these data suggest that HF intake induces different effects in WT mice compared to ApoE4 and ApoE-/- with respect to markers for cognition and neurodegeneration. We propose that HF intake inhibits the compensatory mechanisms of neuroinflammation and neurogenesis in aged female ApoE4 and ApoE-/- mice.

  7. Reflection group on &apos;Expert Culture&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Eggermont, G

    2000-07-01

    As part of SCK-CEN&apos;s social sciences and humanities programme, a reflection group on &apos;Expert Culture&apos; was established. The objectives of the reflection group are: (1) to clarify the role of SCK-CEN experts; (2) to clarify the new role of expertise in the evolving context of risk society; (3) to confront external views and internal SCK-CEN experiences on expert culture; (4) to improve trust building of experts and credibility of SCK-CEN as a nuclear actor in society; (5) to develop a draft for a deontological code; (6) to integrate the approach in training on assertivity and communication; (7) to create an output for a topical day on the subject of expert culture. The programme, achievements and perspectives of the refection group are summarised.

  8. Outline of year-round ski facility &apos;LALAPORT SKI DOME &apos;SSAWS'&apos;. Lalaport ski dome &apos;SSAWS&apos; no keikaku gaiyo

    Energy Technology Data Exchange (ETDEWEB)

    Kayo, M. (Kajima Corp., Tokyo (Japan)); Suzuki, T. (NKK Corp., Tokyo (Japan))

    1994-03-31

    This paper introduces the world&apos;s first indoor snow-fall type artificial ski facility &apos;SSAWS&apos;. Skiing can be enjoyed throughout a year by virtue of artificial snow making machines. Snow quality control requires that the temperature in the ski slope be kept below the freezing point at all times. Means to achieve the requirement included reducing outer wall load by using heat insulation, recovering waste heat from the ski slope by using heat pipes, preventing cold air from leaking and outside air from entering, and adopting a cogeneration system. The cold heat source is a warm water absorbing freezer utilizing waste heat from a gas engine for the cogeneration. The cogeneration system has saved more than 60% of the air conditioning and hot water supplying energy, reducing the annual expense by 15%. The snow making system has a nozzle jet out very highly homogeneous and microfine water droplets with compressed air, and freeze them at -5[degree]C utilizing adiabatic expansion into snow to fall on the slope. The system can control the snow quality as required. The floor of the ski slope is in contact with atmosphere, where snow melting progresses from the lower part as a result of temperature gradient. Therefore, neither special heat source is required, nor a work to scrape and remove the snow that has been stained. 4 refs., 11 figs.

  9. &apos;&apos;Rio+20 on site&apos;&apos;. Communities on their way to sustainability. Examples from Germany; &apos;&apos;Rio+20 vor Ort&apos;&apos;. Kommunen auf dem Weg zur Nachhaltigkeit. Beispiele aus Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Nolting, Katrin; Goell, Edgar

    2012-03-15

    20 years ago, the international community adopted the concept of &apos;sustainable development&apos; as a model for the 21st century adopted in order to meet the growing challenges facing the mankind. With Agenda 21, the UN presented a global action plan for the implementation of such a sustainable development. This brochure provides an insight into sustainability activities at local level in Germany. It is shown how such activities result in future-oriented and exemplary developments in some areas and selected areas of action.

  10. &apos;Biomoleculas&apos;: cellular metabolism didactic software

    Energy Technology Data Exchange (ETDEWEB)

    Menghi, M L [Chair of Physiology and Biophysics, Facultad de Ingenieria, Universidad Nacional de Entre Rios, CC 57 Suc 3, Parana 3100, Entre Rios (Argentina); Novella, L P [Chair of Physiology and Biophysics, Facultad de Ingenieria, Universidad Nacional de Entre Rios, CC 57 Suc 3, Parana 3100, Entre Rios (Argentina); Siebenlist, M R [Chair of Physiology and Biophysics, Facultad de Ingenieria, Universidad Nacional de Entre Rios, CC 57 Suc 3, Parana 3100, Entre Rios (Argentina)

    2007-11-15

    &apos;Biomoleculas&apos; is a software that deals with topics such as the digestion, cellular metabolism and excretion of nutrients. It is a pleasant, simple and didactic guide, made by and for students. In this program, each biomolecule (carbohydrates, lipids and proteins) is accompanied until its degradation and assimilation by crossing and interrelating the different metabolic channels to finally show the destination of the different metabolites formed and the way in which these are excreted. It is used at present as a teaching-learning process tool by the chair of Physiology and Biophysics at the Facultad de Ingenieria - Universidad Nacional de Entre Rios.

  11. Intelligent marketing of electricity from decentral power sources. Project results of the research project &apos;'Massig'&apos;; Intelligente Vermarktung von Strom aus dezentralen Energiequellen. Projektergebnisse des Forschungsvorhabens &apos;'Massig'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Erge, Thomas; Sauer, Christian [Fraunhofer-Institut fuer Solare Energiesysteme ISE, Freiburg (Germany); Barnsteiner, Martin; Preiser, Klaus [Badenova Waermeplus GmbH und Co.KG, Freiburg (Germany)

    2011-07-01

    In the European research project &apos;Market Access for Smaller Size Intelligent Electricity Generation (Massig)&apos; scientists at the Fraunhofer Institute for Solar Energy Systems (Freiburg, Federal Republic of Germany) examined together with project partners the demand-oriented supply and commercialization of electricity from decentral power generators at the liberalized electricity market. The project team selected target countries and evaluated innovative solutions of marketing especially for specific applications of practice. Such a model project is that of Badenova Waermeplus GmbH (Freiburg, Federal Republic of Germany).

  12. An exercise in &apos;anhomomorphic logic&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Sorkin, Rafael D [Perimeter Institute, 31 Caroline Street North, Waterloo ON, N2L 2Y5 (Canada); Department of Physics, Syracuse University, Syracuse, NY 13244-1130 (United States)

    2007-05-15

    A classical logic exhibits a threefold inner structure comprising an algebra of propositions U, a space of &apos;truth values&apos; V, and a distinguished family of mappings {phi} from propositions to truth values. Classically U is a Boolean algebra, V = Z{sub 2}, and the admissible maps {phi}: U Z{sub 2} are homomorphisms. If one admits a larger set of maps, one obtains an anhomomorphic logic that seems better suited to quantal reality (and the needs of quantum gravity). I explain these ideas and illustrate them with three simple examples.

  13. The Skeletal Response to Estrogen is Impaired in Female but not in Male Steroid Receptor Coactivator (SRC)-1 Knock Out Mice

    OpenAIRE

    Mödder, U. I.; Sanyal, A.; Xu, J; O’Malley, B.W.; Spelsberg, T C; Khosla, S.

    2007-01-01

    Estrogen (E) is critical for the maintenance of bone mass in both female and male mice and steroid receptor coactivator (SRC)-1 has been shown to be important for mediating E effects on bone, at least in female mice. In the present study, we defined the skeletal phenotype of male SRC-1 knock out (KO) mice and compared it with their female littermates. Further, to determine the role of SRC-1 in mediating effects of E on bone in male mice, we examined the skeletal effects of gonadectomy (gnx) w...

  14. The effects of the apoE4 genotype on the developing mouse retina.

    Science.gov (United States)

    Maharshak, Idit; Salomon-Zimri, Shiran; Antes, Ran; Liraz, Ori; Nisgav, Yael; Livnat, Tami; Weinberger, Dov; Colton, Carol A; Solomon, Arieh S; Michaelson, Daniel M

    2016-04-01

    Apolipoprotein E4 (apoE4), the most prevalent genetic risk factor for Alzheimer's disease (AD), is associated with neuronal and vascular impairments. The retina, which is as an extension of the central nervous system (CNS), is a particularly suitable model for studying developmental and functional aspects of the neuronal and vascular systems. This study investigates the apoE4-dependent developmental effects on the retinal vasculature and neuronal systems and on the levels of apoE and the vascular endothelial growth factor (VEGF) in the retina. This was performed utilizing retinas of 4, 7, 12, and of 120-day-old human-apoE4-targeted replacement mice and of corresponding mice that express the AD benign isoform, apoE3. The results obtained revealed retinal vascular pathology in the apoE4 mice, which started on the early post-natal days. This includes transient increase in vascular branching, and vascular buds which are round vascular elements representing sprouting or retracting vessels. These effects peaked and ended during the neonatal period. Examination of the synaptic system utilizing the pre-synaptic marker synaptophysin revealed a significant decrease of retinal synaptic density in the apoE4 mice, which was detectable by post-natal day 12 (P12). These morphological changes are associated with neonatal age-dependent elevation in the apoE levels in both apoE3 and apoE4 retinas which is more profound in the apoE4 mice and a corresponding increase in VEGF levels, which is less profound in the apoE4 mice. Additionally, we observed lower levels of retinal VEGF in the apoE4 mice compared to the apoE3 mice retinas on P12. These results show that apoE4 has a transient vascular effect during retinal development that ends in the neonatal period, which is accompanied by a synaptic effect that begins at the end of the neonatal period. These findings show that the apoE4 genotype can have distinct developmental effects on both the retinal vasculature and on neurons and

  15. Hemorrhage associated with &apos;bone crisis&apos; in Gaucher&apos;s disease identified by magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Horev, G.; Kornreich, L. (TA Univ., Petach-Tikva (Israel). Dept. of Pediatric Radiology); Hadar, H. (TA Univ., Petach-Tikva (Israel). Dept. of Radiology); Katz, K. (TA Univ., Petach-Tikva (Israel). Dept. of Pediatric Orthopedics)

    1991-10-01

    Children suffering from Gaucher&apos;s disease were examined by magnetic resonance imaging (MRI) during a characteristic episode of &apos;bone crisis&apos;. An unexpectedly high intramedullary as well as subperiosteal signal was observed on both the T1- and T2-weighted sequences in 5 patients, suggesting a subacute hemorrhage or hematoma. It is conceivable that such a painful hemorrhage is an important component of the &apos;bone crisis&apos; phenomenon. Furthermore, in these cases this is a specific sign which may enable differentiation of bone crises from other types of bone pain associated with Gaucher&apos;s disease. (orig.).

  16. ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations.

    Directory of Open Access Journals (Sweden)

    Benfeard Williams

    2015-10-01

    Full Text Available The increased risk of developing Alzheimer's disease (AD is associated with the APOE gene, which encodes for three variants of Apolipoprotein E, namely E2, E3, E4, differing only by two amino acids at positions 112 and 158. ApoE4 is known to be the strongest risk factor for AD onset, while ApoE3 and ApoE2 are considered to be the AD-neutral and AD-protective isoforms, respectively. It has been hypothesized that the ApoE isoforms may contribute to the development of AD by modifying the homeostasis of ApoE physiological partners and AD-related proteins in an isoform-specific fashion. Here we find that, despite the high sequence similarity among the three ApoE variants, only ApoE4 exhibits a misfolded intermediate state characterized by isoform-specific domain-domain interactions in molecular dynamics simulations. The existence of an ApoE4-specific intermediate state can contribute to the onset of AD by altering multiple cellular pathways involved in ApoE-dependent lipid transport efficiency or in AD-related protein aggregation and clearance. We present what we believe to be the first structural model of an ApoE4 misfolded intermediate state, which may serve to elucidate the molecular mechanism underlying the role of ApoE4 in AD pathogenesis. The knowledge of the structure for the ApoE4 folding intermediate provides a new platform for the rational design of alternative therapeutic strategies to fight AD.

  17. ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations.

    Science.gov (United States)

    Williams, Benfeard; Convertino, Marino; Das, Jhuma; Dokholyan, Nikolay V

    2015-10-01

    The increased risk of developing Alzheimer's disease (AD) is associated with the APOE gene, which encodes for three variants of Apolipoprotein E, namely E2, E3, E4, differing only by two amino acids at positions 112 and 158. ApoE4 is known to be the strongest risk factor for AD onset, while ApoE3 and ApoE2 are considered to be the AD-neutral and AD-protective isoforms, respectively. It has been hypothesized that the ApoE isoforms may contribute to the development of AD by modifying the homeostasis of ApoE physiological partners and AD-related proteins in an isoform-specific fashion. Here we find that, despite the high sequence similarity among the three ApoE variants, only ApoE4 exhibits a misfolded intermediate state characterized by isoform-specific domain-domain interactions in molecular dynamics simulations. The existence of an ApoE4-specific intermediate state can contribute to the onset of AD by altering multiple cellular pathways involved in ApoE-dependent lipid transport efficiency or in AD-related protein aggregation and clearance. We present what we believe to be the first structural model of an ApoE4 misfolded intermediate state, which may serve to elucidate the molecular mechanism underlying the role of ApoE4 in AD pathogenesis. The knowledge of the structure for the ApoE4 folding intermediate provides a new platform for the rational design of alternative therapeutic strategies to fight AD.

  18. The new site selection process in Germany. Results of the &apos;&apos;Commission Disposal of High Radioactive Waste&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Brammer, Klaus-Juergen; Weber, Stefan [GNS Gesellschaft fuer Nuklear-Service mbH, Essen (Germany)

    2016-10-15

    After the open exploration of the salt dome Gorleben was suspended for political reasons and in favour of a new selection process in Germany the German Bundestag passed the site selection law mid-2013. It provides a three-phase process, which shall lead to the designation of a site with &apos;&apos;best possible safety&apos;&apos; in particular for highly radioactive waste in the year 2031. Early July 2016 the &apos;&apos;Commission Disposal of High Radioactive Waste&apos;&apos; submitted now its final report. Thus it is up to the legislator to legally implement the commission&apos;s recommendations and to clear the path for the start of phase 1 of the selection process.

  19. Design of the fuel element &apos;snow-flake&apos; in uranium oxide, canned with aluminium, for the experimental reactor EL 3 (1960); Etude d&apos;un element combustible en oxyde d&apos;uranium gaine d&apos;aluminium, type &apos;&apos;cristal de neige&apos;&apos; pour la pile EL 3 (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Gauthron, M.; Guibert, B. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    This report sums up the main studies have been carried out on the fuel element &apos;Snowflake&apos; (uranium oxide, canned with aluminium), designed to replace the present element of the experimental reactor EL3 in order to increase the reactivity without modifying the neutron flux/thermal power ratio. (author) [French] Ce rapport resume les principales etudes qui ont ete faites sur l&apos;element combustible &apos;Cristal de Neige&apos; (a oxyde d&apos;uranium, gaine d&apos;aluminium) destine a remnlacer l&apos;element actuel du reacteur experimental EL3, afin d&apos;en augmenter la reactivite sans modifier le rapport flux neutronique-puissance thermique. (auteur)

  20. The human apoE7 and apoE4 transgenic mice models

    Institute of Scientific and Technical Information of China (English)

    SUN; Mingzeng; (

    2001-01-01

    [1]Weisgraber, K. H., Apolipoprotein E: Structure-function relationships, Adv. Pro. Chem., 1994, 45: 249-302.[2]Center, G. F., Paoletti, E. G., Apolipoprotein function in health and disease: Insights from natural mutations, Europ. J. Clin. Invest., 1996, 26: 733-746.[3]Browner, J. D., van Dormal, J. J., Muskiet, A. J., Clinical chemistry of common apolipoproteins, J. Chromat. B, 1996, 678: 623-641.[4]Maeda, H., Nakamura, H., Shozo, K. et al., Identification of human apolipoprotein E variant gene: Apolipoprotein E7 (Glu244, 245 Lys244, 245), J. Biochm., 1989, 105: 51-54.[5]Taylor, J. M., Downstream regulatory elements stimulate expression of the human plipoprotein E gene in the liver and suppress expression in the kidney of transgenic mice, Transassoc. Am. Physicians, 1990, 103: 119-128.[6]Smith, J. D., Plump, A. S., Breslow, J. L. et al., Accumulation of human apolipoprotein E in the plasma of transgenic mice, J. Biol. Chem., 1990, 265(25): 14709-14712.[7]Tazio, S., Lee, Y. L., Ji, Z. S. et al., Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E, J. Clin. Invest., 1993, 92(3): 1497-1503.[8]Arn, M. J., Maagdenberg, M., Hofker, M. N. et al., Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia, The J. Biol. Chem., 1993, 268(14): 10540-10545.[9]Qi, Z. H., Ru, K., Sun, M. Z. et al., The gene expression of pME in mouse NIH/3T3 cells and construction of the h-apoE transgenic mice, Chinese Biochem. J., 1997, 13(1): 24-28.[10]Sambrook, J., Fritsch, E. F., Maniatis, T., Molecular Cloning, A Laboratory Manual, New York: CSH Press, 1989, 81.[11]Hogan, B. L., Manipulation the mouse embryo, A Laboratory Manual, New York: CSH Press, 1989, 89.[12]Wandell, M. R., Rall, S. C., Brennan, S. Jr et al., Apolipoprotein E2-Dunedin (228 Arg-Cys): Anapolipoprotein E2 variant with normal receptor-binding activity, J. Lip. Res., 1990, 31: 534-543.[13

  1. OPEC&apos;s strategies

    Energy Technology Data Exchange (ETDEWEB)

    Wirl, Franz [Vienna Univ. (Austria). Faculty of Business, Economics and Statistics

    2012-09-15

    This paper investigates rationale explanations of OPEC&apos;s strategies. Accounting for market characteristics in particular the sluggishness of demand and supply allows to explain price jumps as rational OPEC strategies from a narrow economic perspective (up and down) as well as from political objectives (at least up) due to the political payoff from standing up against the &apos;West&apos;. Although the temptation to accrue this political payoff was and remains high, the narrow economic profit motive coupled with an imperfect cooperation among OPEC members explains past price volatility and high prices much better than the usual reference to political events. A more specific prediction is that OPEC will switch back to setting prices since the current quantity strategy encourages oil importing countries to appropriate rents in particular in connection with the need to mitigate global warming. (orig.)

  2. Male Adolescent Contraceptive Utilization.

    Science.gov (United States)

    Finkel, Madelon Lubin; Finkel, David J.

    1978-01-01

    The contraceptive utilization of a sample of sexually active, urban, high school males (Black, Hispanic, and White) was examined by anonymous questionnaire. Contraceptive use was haphazard, but White males tended to be more effective contraceptors than the other two groups. Reasons for nonuse were also studied. (Author/SJL)

  3. A model for economical integration of &apos;&apos;Green power&apos;&apos; into the grid. VDE-Study &apos;Smart Distribution 2020&apos;; Ein Modell fuer die wirtschaftliche Integration von Oekostrom ins Netz. VDE-Studie &apos;Smart Distribution 2020&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Jopp, Klaus

    2008-07-01

    The model of this study motivates &apos;'green'&apos; power generation due to the demand in the frame of virtual power plants, therefore the connection of green power generators regulated consumers and power storage. Conditions for virtual power plants is an &apos;&apos;Apollo program&apos;&apos; for an armament to the grids by information- and communication technologies as investigation on advanced storage engineering. With special efforts Germany should be able to play a leading role on intelligent grid management, which may be developed as an import hit. (GL)

  4. Test on an external wall. Ecological model project and PV test stand: The Vienna &apos;'Energybase'&apos;; Fassade als Pruefstand. Oekologisches Modellprojekt und gleichzeitig Photovoltaikteststand: Das &apos;Energybase&apos; in Wien

    Energy Technology Data Exchange (ETDEWEB)

    Siemer, J.

    2008-08-15

    Solar cooling, room air humidification with plants, and daylighting even of the underground garage: The Vienna &apos;'Energybase'&apos; office building is a demonstration project in many ways. Its PV system on the south-facing external wall profits from the architecture with its single-minded orientation along renewable energy use. The building will be used by the Arsenal Research research institute for module and current inverter testing. (orig.)

  5. Abundance, composition and growth rate of coral recruits on dead corals following the 2010 bleaching event at Mu Ko Surin, the Andaman Sea

    Science.gov (United States)

    Yucharoen, Mathinee; Yeemin, Thamasak; Casareto, Beatriz E.; Suzuki, Yoshimi; Samsuvan, Watchara; Sangmanee, Kanwara; Klinthong, Wanlaya; Pengsakun, Sittiporn; Sutthacheep, Makamas

    2015-06-01

    Elevated seawater temperatures in the summer months of 2010 were associated with widespread coral mortality in Thailand. A large number of corals at Mu Ko Surin died following the bleaching event. Understanding of the recruitment of corals would improve our ability to predict the potential for coral recovery from the impacts of bleaching events, as well as the interpretation of spatio-temporal variability in coral community structure. This study aims to examine the composition, abundance and growth rate of juvenile corals and the potential of reef recovery at Mu Ko Surin in order to help to understand how reefs react to major disturbances. We found that the densities of coral recruits varied among years and study sites. In the year 2011, coral recruitments ranged between 0.18 ± 0.02 to 1.67 ± 0.07 recruits per m2 for 10 study sites. While in 2012, the monitoring revealed a range between 0.96 ± 0.16 and 2.19 ± 0.21 recruits per m2 from 5 study sites. Fungia, Acropora, Porites and Favites were the dominant groups of coral recruits. In terms substrate forms, they were significant differences between sampling years but the preferential dominant substrate forms did not differ. The Acropora recruits at Ko Torinla showed normal distributions of size class during the two periods. Their ranges in 2011 and 2012 were 4-30 and 13-54 mm, respectively. Six species of Acropora recruits, i.e. Acropora intermedia, A. nasuta, A. cerealis, A. subulata, A. muricata and A. latistella were found. They showed diverse growth rates due to the spatial distribution of 2.11 ± 0.59 to 7.47 ± 1.37 cm per year. This study provides useful data in terms of coral recruitment and recovery from degradation and disturbance, especially from temperature changes induced by coral bleaching. The findings suggest that there is the possibility for coral recovery around Mu Ko Surin following the 2010 bleaching event.

  6. Možnost ponovne uporabe regeneracijske odpadne vode pri ionskem izmenjevalcu za mehčanje vode v Pivovarni Laško

    OpenAIRE

    Nemec, Nina

    2016-01-01

    Pivovarska industrija je en izmed velikih porabnikov vode, ki hkrati proizvaja tudi velike količine industrijske odpadne vode, ki obremenjujejo ekosistem. Teh težav se zavedajo tudi v podjetju Pivovarna Laško, ki kot IPPC (Integrated Pollution Prevention and Control – celovito preprečevanje in nadzor onesnaževanja) zavezanec nenehno optimizira uporabo vode v proizvodnem procesu, hkrati pa skrbi za ustrezno ravnanje z odpadnimi vodami. V magistrskem delu smo raziskali možnost ponovne uporabe r...

  7. ZAPADNOHRVATSKE POVIJESNE TEME - Franjo Emanuel Hoško, Povijesno društvo Rijeka, Adamić, Rijeka, 2009., 466 stranica.

    OpenAIRE

    JURČEVIĆ, Marijan

    2010-01-01

    Umirovljeni redovni profesor naše Teologije, područnog studija Katoličkog bogoslovnog fakulteta Sveučilišta u Zagrebu, Franjo Emanuel Hoško još je uvijek honorarni profesor Teologije u Rijeci i Odsjeka za povijest Filozofskog fakulteta Sveučilišta u Rijeci. Dugogodišnje djelovanje u Rijeci usmjerilo ga je i u njegovim povijesnim istraživanjima. Ova je knjiga zapravo zbirno djelo njegovih radova o različitim povijesnim temama koje jasno ujedinjuje prostor proučavanja, a to je zapadna Hrvatska....

  8. Cash management system &apos;CEREUS-SM&apos;; Supermarket muke kinsen shoriki &apos;CEREUS-SM&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Niizuma, N.; Fukushima, Y.; Kinoshita, S. [Fuji Electric Co. Ltd., Tokyo (Japan)

    2000-03-10

    The adjustment system with change in coin has reduced cashier work in supermarkets, and has spread as the standard peripheral equipment of the point of sales (POS) system. Recently, there have been customer needs for a type with change in bill and coin. Fuji Electric has developed cash management system &apos;CEREUS-SM&apos; which is as small as the current system only with change in coin and can be handled by anyone, including a part-timer or a student worker. (author)

  9. 2001-2003 &apos;&apos;public utility&apos;&apos; contract between the French government and Gaz de France; Contrat de &apos;&apos;service public&apos;&apos; 2001-2003 entre l&apos;etat et Gaz de France

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    The &apos;&apos;public utility&apos;&apos; contract aims at specifying the actions of Gaz de France (GdF), the French gas utility, in terms of national development and public utility presence at the local scale. It extends and completes the &apos;contract of group&apos; established between the government and GdF in the domain of quality of the services offered to clients, development of gas infrastructures and extension of gas supplies, and sustainable development. (J.S.)

  10. The role of the &apos;&apos;Neutral Service Provider&apos;&apos; in the liberalised gas market; Die Rolle des &apos;&apos;Neutral Service Provider&apos;&apos; im liberalisierten Erdgasmarkt

    Energy Technology Data Exchange (ETDEWEB)

    Peper, F.; Greverath, I. [Viavera GmbH Dortmund (Germany)

    2002-07-01

    The ongoing liberalisation of European gas markets forces network operators as well as retail companies to implement new processes. This article focuses on the challenges for network operators. In this context the potential for &apos;Neutral Service Providers (NSP)&apos; is discussed. Based on sample TPA processes the interaction between the NSP and the network operator is explored. The authors conclude that for many market participants the outsourcing of TPA processes to a specialized service provider has the potential to deliver significant benefits. (orig.) [German] Die fortschreitende Liberalisierung der europaeischen Erdgasmaerkte stellt die Netz- sowie die Vertriebsgesellschaften vor staendig wachsende Anforderungen. Dabei wird in diesem Artikel der Schwerpunkt auf die Komplexitaet der Aufgaben insbesondere fuer Netzbetreiber gelegt. In diesem Zusammenhang werden die hieraus resultierenden Marktchancen fuer neue Dienstleistungsunternehmen, die sogenannten &apos;Neutral Service Provider&apos; (NSP) eroertert. Anhand eines Prozessbeispiels wird die Interaktion zwischen NSP und den von ihm betreuten Netzbetreibern diskutiert. Die Autoren kommen zu dem Schluss, dass fuer viele Marktteilnehmer die Auslagerung bestimmter Unternehmensaktivitaeten im Zusammenhang mit der Bewaeltigung des Netzzugangs Dritter an einen spezialisierten Dienstleister mit erheblichen Vorteilen verbunden ist. (orig.)

  11. &apos;Massless&apos; vector field in de Sitter Universe

    Energy Technology Data Exchange (ETDEWEB)

    Garidi, T.; Gazeau, J-P. [APC, CNRS UMR 7164, Universite Paris 7, Denis Diderot, Boite 7020, F-75251 Paris Cedex 05 (France); Rouhani, S. [Plasma Physics Research Center, Islamic Azad University, P.O.BOX 14835-157, Tehran (Iran, Islamic Republic of); Takook, M.V. [Department of Physics, Razi University, Kermanshah (Iran, Islamic Republic of)

    2006-04-15

    In the present work the massless vector field in the de Sitter (dS) space has been quantized. &apos;Massless&apos; is used here by reference to conformal invariance and propagation on the dS light-cone whereas &apos;massive&apos; refers to those dS fields which contract at zero curvature unambiguously to massive fields in Minkowski space. Due to the gauge invariance of the massless vector field, its covariant quantization requires an indecomposable representation of the de Sitter group and an indefinite metric quantization. We will work with a specific gauge fixing which leads to the simplest one among all possible related Gupta-Bleuler structures. The field operator will be defined with the help of coordinate independent de Sitter waves (the modes) which are simple to manipulate and most adapted to group theoretical matters. The physical states characterized by the divergence-lessness condition will for instance be easy to identify. The whole construction is based on analyticity requirements in the complexified pseudo-Riemannian manifold for the modes and the two-point function. (authors)

  12. ApoE mimetic peptide decreases Aβ production in vitro and in vivo

    Directory of Open Access Journals (Sweden)

    Pak Daniel TS

    2010-04-01

    Full Text Available Abstract Background Apolipoprotein E (apoE is postulated to affect brain Aβ levels through multiple mechanisms--by altering amyloid precursor protein (APP processing, Aβ degradation, and Aβ clearance. We previously showed that an apoE-derived peptide containing a double repeat of the receptor-binding region was similarly effective in increasing APP processing in vivo. Here, we further examined whether peptides containing tandem repeats of the apoE receptor-binding region (amino acids 141-149 affected APP trafficking, APP processing, and Aβ production. Results We found that peptides containing a double or triple tandem repeat of the apoE receptor-binding region, LRKLRKRLL, increased cell surface APP and decreased Aβ levels in PS1-overexpressing PS70 cells and in primary neurons. This effect was potentiated by a sequential increase in the number of apoE receptor-binding domain repeats (trimer > dimer > monomer. We previously showed that the apoE dimer increased APP CTF in vivo; to determine whether the dimer also affected secreted APP or Aβ levels, we performed a single hippocampal injection of the apoE dimer in wild-type mice and analyzed its effect on APP processing. We found increased sAPPα and decreased Aβ levels at 24 hrs after treatment, suggesting that the apoE dimer may increase α-secretase cleavage. Conclusions These data suggest that small peptides consisting of tandem repeats of the apoE receptor-binding region are sufficient to alter APP trafficking and processing. The potency of these peptides increased with increasing repeats of the receptor binding domain of apoE. In addition, in vivo administration of the apoE peptide (dimer increased sAPPα and decreased Aβ levels in wild-type mice. Overall, these findings contribute to our understanding of the effects of apoE on APP processing and Aβ production both in vitro and in vivo.

  13. Vertigo Imaging; Clinical Radiology&apos;

    Directory of Open Access Journals (Sweden)

    Jalal Jalal Shokouhi

    2009-01-01

    Full Text Available   "n- Dizziness that patients complain from are rotational vertigo, sense of instability, ataxia of gait, disturbance of vision, loss of contact with surroundings, nausea, loss of memory, loss of confidence, epileptic convulsion and dizziness that is considered by medical staff are: "n1- Vertigo as a sense of feeling the environment moving when it does not persist in all positions, aggravated by head movement. "n2- Disequilibrium as a feeling of unsteadiness or insecurity without rotation, standing and walking are difficult. "n3- Light headedness as swimming, floating, giddy or swaying sensation in the head or in the room. "nTaking the history from a vertigo patient:* "n            What the patient means by vertigo?- "n- Time of onset "n-Temporal pattern "n-Associated signs and symptoms &apos;&apos; tinnitus, hearing loss, headache, double vision, numbness and difficulty in swallowing &apos;&apos;. "n- Precipitating, aggravating and relieving factors. "n- If episodic: sequence of events, activity at onset, aura, severity and amnesia. "n*Examination of the vertigo patient checking: "nSpontaneous nystagmus, positional nystagmus, optokinetic nystagmus, posture and balance control like romberg&apos;s test, blind walking, untenberger and barany&apos;s test, stimulation of labyrinth, caloric test &apos;&apos; cold, warm water &apos;&apos; and the rotational test. "nEtiology : "n*Spontaneous nystagmus: "nPosture and balance control is positive with nausea , vomiting , sweating and anxiety : harmonic vestibular sy with loss of hearing , tinnitus , vestibular neuronitis , meniere disease and with otologic origin and dysharmmonic vestibular sy , with numbness , double vision , dysarthria in brain stem infarct and with a neurological origin. "nNonspontaneous nystagmus :Posture and balance negative with nausea, vomiting in GI disorders and internal medicine , sweating and trachycardia by chest pain in angina , M.I &apos;&apos; cardiology &apos;&apos

  14. Effects of nocturnal aircraft noise on sleep: results from the &apos;&apos;quiet air traffic&apos;&apos; project; Wirkungen des Nachtfluglaerms auf den Schlaf: Ergebnisse aus dem Projekt &apos;&apos;Leiser Flugverkehr&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Samel, A.; Basner, M.; Maass, H.; Mueller, U.; Quehl, J.; Wenzel, J. [Deutsches Zentrum fuer Luft- und Raumfahrt (DLR) in der Helmholtz-Gemeinschaft (HGF), Inst. fuer Luft- und Raumfahrtmedizin, Koeln (Germany)

    2005-07-01

    In 192 sleep-healthy subjects (18 to 65 y) effects of nocturnal aircraft noise on sleep, stress, performance and subjective factors were investigated in 2240 nights under laboratory and field conditions. In the sleep lab, 112 volunteers were subjected to aircraft noise events by varying numbers and noise levels during 9 nights within a period of 13 nights. 16 further subjects served as control group (i.e. without any noise). 64 subjects were studied in the vicinity of Cologne-Bonn airport during 9 nights. Polysomnographical and acoustical recordings, determination of excretion rates of stress hormones from night urines, performance tests and questionnaires were conducted during all days for the assessment of nocturnal aircraft noise effects. By simultaneous recording of electrophysiological and acoustical data the probability of noise induced awakenings was estimated. Performance and most of psychological parameters did not show significant dose-effect relationships, whereas annoyance did. Epinephrine and norepinephrine did not change under aircraft noise, cortisol did change only in the lab. In the lab, a comparison between all noisy nights and noise-free baseline nights exhibited a non-significant 2-min. reduction of sleep and a 4-min. decrease of slow-wave sleep. In the field, awakenings caused by aircraft noise were detected above a threshold of 33 dB(A) &apos;&apos;at the sleeper&apos;s ear&apos;&apos;. All effects were much less pronounced in the field than in the lab. For the first time, precise dose-effect curves between maximum aircraft noise event levels and electrophysiologically detectable awakenings, and a threshold were empirically established. The results of these studies broadens the knowledge on aircraft noise induced sleep disturbances and immediate consequences for the next day. (orig.)

  15. Data acquisition and control using National Instruments&apos; LabVIEW&apos;&apos; software

    Energy Technology Data Exchange (ETDEWEB)

    Kirkman, I.W.; Buksh, P.A. (SERC Daresbury Laboratory, Warrington, Cheshire WA4 4AD (United Kingdom))

    1992-01-01

    Using conventional programming techniques for the production of data acquisition and control software can be a time-consuming procedure, and the code subsequently produced can often be inflexible and rather difficult to modify in the light of changing experimental requirements. A new generation of commercial software products have recently appeared which it is claimed can significantly reduce development times and give rise to more flexible code and improved user interfaces. An example of such a product is National Instruments&apos; LabVIEW,&apos;&apos; which presents a novel graphical approach based on Apple Macintosh computer platforms. Extensive use of LabVIEW has been made by the Soft X-ray Group at Daresbury Laboratory over the past two years, and its performance is reported on here. Several examples of experimental arrangements for which it has been used are described, and an evaluation of the product is made.

  16. Predictors of male microchimerism

    DEFF Research Database (Denmark)

    Kamper-Jørgensen, Mads; Mortensen, Laust Hvas; Andersen, Anne-Marie Nybo

    2012-01-01

    confounding and reverse causation. To address the issue of confounding, we conducted an analysis of predictors of male microchimerism in 272 female participants of the Danish Diet, Cancer and Health cohort. Buffy coat DNA was tested for Y chromosome presence as a marker of male microchimerism. First, we used...... logistic regression and thereafter random forest modeling to evaluate the ability of a range of reproductive, lifestyle, hospital or clinic visit history, and other variables to predict whether women tested positive for male microchimerism. We found some indication that current use of contraceptive pills...

  17. Aerosol activity distribution on aerodynamic diameter inside the object &apos;'Shelter'&apos;: physical and dosimetric aspects

    Energy Technology Data Exchange (ETDEWEB)

    Bondarenko, O.A.; Aryasov, P.B.; Medvedev, S.Yu.; Nesmiyan, I.M. [Radiation Protection Inst., Kiev (Ukraine); Zhidkov, A.V. [ISTC ' ' Shelter' ' , Chernobyl, Kiev (Ukraine)

    2001-07-01

    Experimental results of the aerosol size distribution inside the Object &apos;'Shelter'&apos; are evaluated in the work. The results show a consistent and significant contribution of sub-micron fraction to the total aerosol activity. Different methods of interpretation of impactor data series are evaluated in terms of adequate assessment of the separate sub-micron aerosol fraction. The contribution of the sub-micron component to the total aerosol activity was found to be about 35%. Results of this research were also compared to those of other authors conducted with by using identical impactor equipment, e.g. results of aerosol sampling at a Czech NPP Dukovany. It is demonstrated in the work that observation of such a significant contribution of the sub-micron fraction for the Shelter aerosol can be hardly explained by systematic failure of the sampling equipment. Also physical mechanisms and corresponding observations of sub-micron aerosol generation inside the Shelter as well as subsequent dosimetric aspects are discussed. (orig.)

  18. &apos;'Green'&apos; Biopolymers for Improved Decontamination of Metals from Surfaces: Sorptive Characterization and Coating Properties

    Energy Technology Data Exchange (ETDEWEB)

    Davison, Brian H.; Kuritz, Tanya

    2000-06-01

    The proposed research aims to develop a fundamental understanding of important biological and physical chemical parameters for effective decontamination of metal surfaces using environmentally benign aqueous-based biopolymer solutions. Understanding how heavy metal-chelating biopolymers coat and interact with contaminated surfaces will benefit the development of novel, safe, easy-to-apply decontamination methodologies for removal of radionuclides and heavy metals. The benefits of these methodologies will include the following: (1) decreased exposure hazards for workers; (2) decreased secondary waste generation; (3) increased efficiency of decontamination; (4) positive public appeal and development of novel, nature-friendly business opportunities; and (5) lower cost of cleanup to the government. We propose to use aqueous biopolymer solutions to coat a contaminated metal surface (i.e., steel), solubilize the heavy metals (e.g., uranium) from the surface, and bind the heavy metals into the biopolymer. The biopolymer coating (containing the immobilized hazardous metal contaminants) will then be removed as a viscous film, as a dry powder, or by washing. This &apos;&apos;apply, wait, and remove&apos;&apos; procedure will reduce the amount of worker time spent in decontamination activities.

  19. &apos;'Green'&apos; Biopolymers for Improved Decontamination of Metals from Surfaces: Sorptive Characterization and Coating Properties

    Energy Technology Data Exchange (ETDEWEB)

    Davison, Brian H.; Kurtiz,Tanya

    1999-06-01

    The proposed research aims to develop a fundamental understanding of important biological and physical chemical parameters for effective decontamination of metal surfaces using environmentally benign aqueous-based biopolymer solutions. Understanding how heavy metal-chelating biopolymers coat and interact with contaminated surfaces will benefit the development of novel, safe, easy-to-apply decontamination methodologies for removal of radionuclides and heavy metals. The benefits of these methodologies will include the following: (1) decreased exposure hazards for workers; (2) decreased secondary waste generation; (3) increased efficiency of decontamination; (4) positive public appeal and development of novel, nature-friendly business opportunities; and (5) lower cost of cleanup to the government. We propose to use aqueous biopolymer solutions to coat a contaminated metal surface (i.e., steel), solubilize the heavy metals (e.g., uranium) from the surface, and bind the heavy metals into the biopolymer. The biopolymer coating (containing the immobilized hazardous metal contaminants) will then be removed as a viscous film, as a dry powder, or by washing. This &apos;&apos;apply, wait, and remove&apos;&apos; procedure will reduce the amount of worker time spent in decontamination activities.

  20. &apos;'Green'&apos; Biopolymers for Improved Decontamination of Metals from Surfaces: Sorptive Characterization and Coating Properties

    Energy Technology Data Exchange (ETDEWEB)

    Davison, Brian H.

    2002-04-30

    The proposed research aimed to develop a fundamental understanding of important biological and physical chemical parameters for effective decontamination of metal surfaces using environmentally benign aqueous-based biopolymer solutions. Understanding how heavy metal-chelating biopolymers coat and interact with contaminated surfaces will benefit the development of novel, safe, easy-to-apply decontamination methodologies for removal of radionuclides and heavy metals. The benefits of these methodologies include the following: decreased exposure hazards for workers; decreased secondary waste generation; increased efficiency of decontamination; positive public appeal and development of novel, nature-friendly business opportunities; and lower cost of cleanup to the government. We proposed to use aqueous biopolymer solutions to coat a contaminated metal surface (i.e., steel), solubilize the heavy metals (e.g., uranium) from the surface, and bind the heavy metals into the biopolymer. The biopolymer coating (containing the immobilized hazardous metal contaminants) was to be removed as a viscous film, as a dry powder, or by washing. This &apos;&apos;apply, wait, and remove&apos;&apos; procedure will reduce the amount of worker time spent in decontamination activities.

  1. Imaging of bridging vein thrombosis in infants with abusive head trauma: the &apos;&apos;Tadpole Sign&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Hahnemann, Maria L.; Kinner, Sonja; Schweiger, Bernd [University Hospital Essen, Institute of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); Bajanowski, Thomas [University Hospital Essen, Institute of Legal Medicine, Essen (Germany); Karger, Bernd; Pfeiffer, Heidi; Wittschieber, Daniel [University Hospital Muenster, Institute of Legal Medicine, Muenster (Germany)

    2014-10-03

    Abusive head trauma (AHT) in infants is usually diagnosed using a multi-disciplinary approach by investigating the circumstances and identifying morphological indicators, for example, subdural hematomas (SDHs), subdural hygromas (SDHys), retinal haemorrhages and encephalopathy. The present morphological study investigates the incidence, radiological characteristics and non-radiological co-factors of bridging vein thrombosis (BVT) in infants with AHT. From 2002 to 2013, computed tomography (CT) and magnetic resonance imaging (MRI) material of 628 infants aged 0-2 years were analysed retrospectively. If available, medicolegal expert opinions were additionally considered. Cases with SDHs and/or SDHys were identified and systematically evaluated as to the presence and characteristics of BVT. SDHs and/or SDHys were present in 29 of the 81 cases exhibiting morphological abnormalities in the initial CT. Among these, 11 cases (40 %) had BVT (mean age = 5.0 months). BVT could be best depicted in the T1-weighted spin echo and T2*/susceptibility-weighted MRI. In one case, BVT could be depicted indirectly using time-of-flight MR venography. The predominant (73 %) BVT shape was found to be tadpole-like (&apos;&apos;Tadpole Sign&apos;&apos;). In the absence of appropriate accidental trauma, BVT appears to be a strong indicator of AHT. Therefore, the BVT/Tadpole Sign represents compelling cause to search for other signs of AHT. (orig.)

  2. Final Report on Project 01-ERD-017 &apos;&apos;Smart Nanostructures From Computer Simulations&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Grossman, J C; Williamson, A J

    2004-02-13

    This project had two main objectives. The first major goal was to develop new, powerful computational simulation capabilities. It was important that these tools have the combination of the accuracy needed to describe the quantum mechanical nature of nanoscale systems and the efficiency required to be applied to realistic, experimentally derived materials. The second major goal was to apply these computational methods to calculate and predict the properties of quantum dots--initially composed of silicon, but then of other elements--which could be used to build novel nanotechnology devices. The driving factor of our purpose has been that, through the development and successful application of these tools, we would generate a new capability at LLNL that could be used to make nanostructured materials &apos;'smarter'&apos;, e.g., by selectively predicting how to engineering specific, desired properties. To carry out the necessary work to successfully complete this project and deliver on our goals, we established a two-pronged effort from the beginning: (1) to work on developing new, more efficient algorithms and quantum simulation tools, and (2) to solve problems and make predictions regarding properties of quantum dots which were being studied experimentally here at Livermore.

  3. Resonant light power buildup in ALPS, a &apos;&apos;light shining through a wall&apos;&apos;-experiment

    Energy Technology Data Exchange (ETDEWEB)

    Meier, Tobias; Danzmann, Karsten; Willke, Benno [Max-Planck-Institut fuer Gravitationsphysik, Albert Einstein Institut (Germany); Institut fuer Gravitationsphysik, Leibniz Universitaet Hannover, Callinstrasse 38, D-30167 Hannover (Germany); Ehret, Klaus; Ghazaryan, Samvel; Knabbe, Axel; Lindner, Axel; List, Jenny; Meyer, Niels; Notz, Dieter; Redondo, Javier; Ringwald, Andreas [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, D-22607 Hamburg (Germany); Frede, Maik; Hildebrandt, Matthias [Laserzentrum Hannover e.V., Hollerithallee 8, D-30419 Hannover (Germany); Wiedemann, Guenter [Hamburger Sternwarte, Gojenbergsweg 112, D-21029 Hamburg (Germany)

    2009-07-01

    We report on the first successfull application of a new experimental technique to search for weakly interacting sub-eV particles (WISPs) coupling to photons. As part of the ALPS experiment located at DESY in Hamburg, this technique uses an optical resonator to enhance the power inside a HERA dipole magnet on the production side of a typical &apos;&apos;light shining through a wall&apos;&apos;-experiment. We use a frequency doubled continuous-wave laser emitting 0.6 W of power at 532 nm that is stabilized to a linear optical resonator with 8 m length. On resonance we achieve a circulating power of 34 W within the magnet. With this we obtained sensitivities corresponding to a coupling strength of g{approx}5.10{sup -7} GeV{sup -1} for interactions of axion-like particles and photons. The experimental setup and possible improvements are described and compared with common experimental designs with pulsed lasers.

  4. Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender

    Directory of Open Access Journals (Sweden)

    Pereira Thiago MC

    2010-08-01

    Full Text Available Abstract Background Although advanced age is considered a risk factor for several diseases, the impact of gender on age-associated cardiovascular diseases, such as atherosclerotic processes and valvular diseases, remains not completely clarified. The present study was designed to assess aortic valve morphology and function and vascular damage in elderly using the apolipoprotein E knockout (ApoE KO mouse. Our hypothesis was that advanced age-related cardiovascular changes are aggravated in atherosclerotic male mice. Methods The grade (0 to 4 of aortic regurgitation was evaluated through angiography. In addition, vascular lipid deposition and senescence were evaluated through histochemical analyses in aged male and female ApoE KO mice, and the results were compared to wild-type C57BL/6J (C57 mice. Results Aortic regurgitation was observed in 92% of the male ApoE KO mice and 100% of the male C57 mice. Comparatively, in age-matched female ApoE KO and C57 mice, aortic regurgitation was observed in a proportion of 58% and 53%, respectively. Histological analysis of the aorta showed an outward (positive remodeling in ApoE KO mice (female: 1.86 ± 0.15; male: 1.89 ± 0.68 using C57 groups as reference values. Histochemical evaluation of the aorta showed lipid deposition and vascular senescence only in the ApoE KO group, which were more pronounced in male mice. Conclusion The data show that male gender contributes to the progression of aortic regurgitation and that hypercholesterolemia and male gender additively contribute to the occurrence of lipid deposition and vascular senescence in elderly mice.

  5. A rare disease in an atypical location - Kimura&apos;s Disease of the upper extremity

    Energy Technology Data Exchange (ETDEWEB)

    Lam, Alan Cheuk Si; Lau, Vince Wing Hang [Queen Mary Hospital, Department of Radiology, Hong Kong (China); Au Yeung, Rex Kwok Him [University of Hong Kong, Department of Pathology, Li Ka Shing Faculty of Medicine, Hong Kong (China)

    2015-12-15

    Kimura&apos;s disease is a rare chronic inflammatory disorder predominantly affecting young Asian male patients, occurring mainly in the head and neck regions. Kimura&apos;s disease of the upper extremity is extremely rare, and previous case reports in the literature show similar imaging characteristics with consistent location at the medial epitrochlear region, predominantly with unilateral involvement. We present the first reported case of Kimura&apos;s disease affecting the anterolateral aspect of the upper arm, sparing the medial epitrochlear region, illustrating that with typical MR appearance and serology, the involvement of this rare disease in an atypical location still warrants consideration of this diagnosis. There was also bilateral asymmetrical involvement in our patient, suggesting the possibility of a propensity for Kimura&apos;s disease affecting the upper extremities to have bilateral involvement, which may necessitate imaging of the clinically asymptomatic contralateral limb in these patients for early lesion identification and treatment. (orig.)

  6. On the universality of the &apos;'smile'&apos;-gap in the density of states of a chaotic Josephson junction

    Energy Technology Data Exchange (ETDEWEB)

    Reutlinger, Johannes; Belzig, Wolfgang [University of Konstanz, Department of Physics (Germany); Nazarov, Yuli [Kavli Institute of Nanoscience Delft, Delft University of Technology, Delft (Netherlands); Glazman, Leonid [Department of Physics, Yale University, New Haven, CT (United States)

    2015-07-01

    The superconducting proximity effect strongly modifies the local density of states in chaotic Josephson junctions. Recently we found that besides the well-known minigap a secondary gap appears just below the superconducting gap edge Δ in the limit of a large Thouless energy E{sub Th} >or similar Δ. To check the universality of this novel gap phenomenon we study the effect of nonideal contacts and show that the &apos;'smile'&apos;-gap crucially depends on the transmission eigenvalue distribution. In a next step we use the random matrix method to investigate the &apos;'smile'&apos;-gap. This allows us to approach the statistics of Andreev levels, going beyond the quasiclassical Greens function method. It turns out that the hard gap edge softens similar to what is already known from the minigap.

  7. Motivation for Reading and Upper Primary School Students&apos; Academic Achievement in Reading in Kenya

    Science.gov (United States)

    Mucherah, Winnie; Herendeen, Abbey

    2013-01-01

    This study examined primary school students&apos; reading motivation and performance on the standardized exam. Participants included 901 seventh and eighth grade students from Kenya. There were 468 females and 433 males. Contrary to previous studies, results showed reading challenge and aesthetics, but not efficacy, predicted reading achievement,…

  8. mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice.

    Science.gov (United States)

    Dominick, Graham; Bowman, Jacqueline; Li, Xinna; Miller, Richard A; Garcia, Gonzalo G

    2017-02-01

    Studies of the mTOR pathway have prompted speculation that diminished mTOR complex-1 (mTORC1) function may be involved in controlling the aging process. Our previous studies have shown diminished mTORC1 activity in tissues of three long-lived mutant mice: Snell dwarf mice, growth hormone receptor gene disrupted mice (GHRKO), and in this article, mice deficient in the pregnancy-associated protein-A (PAPPA-KO). The ways in which lower mTOR signals slow aging and age-related diseases are, however, not well characterized. Here, we show that Snell, GHKRO, and PAPPA-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT) and N-myc downstream-regulated gene 1 (NDRG1). Furthermore, we report that lowering mTOR enhances MGMT and NDRG1 protein expression via post-transcriptional mechanisms. We show that the CCR4-NOT complex, a post-transcriptional regulator of gene expression, is downstream of the mTORC1 pathway and may be responsible for the upregulation of MGMT and NDRG1 in all three varieties of long-lived mice. Our data thus suggest a novel link between DNA repair and mTOR signaling via post-transcriptional regulation involving specific alteration in the CCR4-NOT complex, whose modulation could control multiple aspects of the aging process.

  9. A Bottom-Up Building Stock Model for Tracking Regional Energy Targets—A Case Study of Kočevje

    Directory of Open Access Journals (Sweden)

    Marjana Šijanec Zavrl

    2016-10-01

    Full Text Available The paper addresses the development of a bottom-up building stock energy model (BuilS for identification of the building stock renovation potential by considering energy performance of individual buildings through cross-linked data from various public available databases. The model enables integration of various EE and RES measures on the building stock to demonstrate long-term economic and environmental effects of different building stock refurbishment strategies. In the presented case study, the BuilS model was applied in the Kočevje city area and validated using the measured energy consumption of the buildings connected to the city district heating system. Three strategies for improving the building stock in Kočevje towards a more sustainable one are presented with their impact on energy use and CO2 emission projections up to 2030. It is demonstrated that the BuilS bottom-up model enables the setting of a correct baseline regarding energy use of the existing building stock and that such a model is a powerful tool for design and validation of the building stock renovation strategies. It is also shown that the accuracy of the model depends on available information on local resources and local needs, therefore acceleration of the building stock monitoring on the level of each building and continually upgrading of databases with building renovation information is of the utmost importance.

  10. Modulation of Muscle Atrophy, Fatigue and MLC Phosphorylation by MuRF1 as Indicated by Hindlimb Suspension Studies on MuRF1-KO Mice

    Directory of Open Access Journals (Sweden)

    Siegfried Labeit

    2010-01-01

    Full Text Available MuRF1 is a member of the TRIM/RBCC superfamily, a gene family that encompasses a large variety of proteins, all sharing the conserved TRIM (Tripartite Motive sequential array of RING, B-box, and coiled-coil domains. Within this family, MuRF1(also named TRIM63 is a specialized member that contributes to the development of muscle atrophy and sarcopenia. Here we studied MuRF1's role in muscle atrophy during muscle unloading induced by hindlimb suspension. Consistent with previous studies, we found that MuRF1 inactivation leads to an attenuated muscle atrophy response. The amount of protection was higher as compared to the denervation model, and within the 10 day-suspension period the soleus muscle was spared from atrophy in MuRF1-KO mice. Contractility studies on hindlimb suspended muscle tissues suggested that MuRF1's functions extend beyond muscle trophicity and implicate MuRF1 in muscle fatigue and MLC phosphorylation control: soleus muscle from MuRF1-KO mice fatigued significantly faster and in addition showed a reduced posttetanic twitch potentiation. Thus the present work further established the role of MuRF1 in muscle atrophy and for the first time shows that MuRF1 plays a role in muscle fatigue and twitch potentiation.

  11. Fermentation of sweet whey by recombinant Escherichia coli K011 Fermentação de soro de leite por Escherichia coli KO11 recombinante

    Directory of Open Access Journals (Sweden)

    Amarildo Ricardo Leite

    2000-09-01

    Full Text Available The production of ethanol from sweet whey using the recombinant Escherichia coli KO11, in batch fermentation, was tested. The maximum ethanol yield was reached after 96h, representing only 38% of the theoretical yield. The supplementation of whey with components of LB broth increased the maximum yield to 96% in 72h. The addition of 0.5% yeast extract to whey resulted in maximum yield of 74% at 36h and it increased to over 100% when yeast extract and trace metals solution (Fe++, Mn++ and Zn++ were added.A produção de etanol a partir de soro de leite empregando a cepa Escherichia coli KO11 recombinante, em fermentação de batelada, foi testada. O rendimento máximo de etanol foi obtido em 96h, representando apenas 38% do rendimento teórico. A suplementação do soro com os componentes do caldo LB aumentou o rendimento para 96% em 72h. A adição de 0,5% de extrato de levedura ao soro resultou em um rendimento máximo de 74% em 36h que aumentou para acima de 100% quando se adicionou extrato de levedura e uma solução de metais traço (Fe++, Mn++ e Zn++.

  12. Inorganic profile of some Brazilian medicinal plants obtained from ethanolic extract and &apos;&apos;in natura&apos;&apos; samples

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, M.O.M.; de Sousa, P.T.; Salvador, V.L.R.; Sato, I.M.

    2004-10-03

    The Anadenathera macrocarpa, Schinus molle, Hymenaea courbaril, Cariniana legalis, Solidago microglossa and Stryphnodendron barbatiman, were collected &apos;&apos;in natura&apos;&apos; samples (leaves, flowers, barks and seeds) from different commercial suppliers. The pharmaco-active compounds in ethanolic extracts had been made by the Mato Grosso Federal University (UFMT). The energy-dispersive x-ray fluorescence (ED-XRF) spectrometry was used for the elemental analysis in different parts of the plants and respective ethanolic extracts. The Ca, Cl, Cu, Fe, K, Mg, Mn, Na, Ni, P, Rb, S, Sr and Zn concentrations were determined by the fundamental parameters method. Some specimens showed a similar inorganic profile for &apos;&apos;in natura&apos;&apos; and ethanolic extract samples and some ones showed a distinct inorganic profile. For example, the Anadenathera macrocarpa showed a similar concentration in Mg, P, Cu, Zn and Rb elements in &apos;&apos;in natura&apos;&apos; and ethanolic extract samples; however very different concentration in Na, S, Cl, K , Ca, Mn, Fe and Sr was observed in distinctive samples. The Solidago microglossa showed the K, Ca, Cl, S, Mg, P and Fe elements as major constituents in both samples, suggesting that the extraction process did not affect in a considerable way the &apos;&apos;in natura&apos;&apos; inorganic composition. The elemental composition of the different parts of the plants (leaves, flowers, barks and seeds) has been also determined. For example, the Schinus molle specimen showed P, K, Cl and Ca elements as major constituents in the seeds, Mg, K and Sr in the barks and Mg, S, Cl and Mn in the leaves, demonstrating a differentiated elementary distribution. These inorganic profiles will contribute to evaluate the quality control of the Brazilian herbaceous trade and also will assist to identify which parts of the medicinal plants has greater therapeutic effect.

  13. Cytogenetic of Male Infertility

    Directory of Open Access Journals (Sweden)

    Lutfiye Ozpak

    2011-08-01

    Full Text Available Infertility by definition, is not to get pregnant within one year of regular sexual relationship without protection, affects 15-20% of reproductive age couples. Approximately 30% of infertility cases are male originated. Male infertility is caused by endocrine-related genetic defects affecting urogenital system function. These defects adversely affect subsequent spermatogenesis, sexual function, fertility, early embryonic stage of sexual maturation. Autosomal and gonosomal, numerical and structural chromosome abnormalities and related syndromes rank at the top causes of male infertility. Similar chromosome abnormalities are detected in male infertility and as the rate of these abnormalities increase, it was found to reduce sperm count especially in azospermic and oligozoospermic men. [Archives Medical Review Journal 2011; 20(4.000: 230-245

  14. Oxidative stress & male infertility.

    Science.gov (United States)

    Makker, Kartikeya; Agarwal, Ashok; Sharma, Rakesh

    2009-04-01

    The male factor is considered a major contributory factor to infertility. Apart from the conventional causes for male infertility such as varicocoele, cryptorchidism, infections, obstructive lesions, cystic fibrosis, trauma, and tumours, a new and important cause has been identified: oxidative stress. Oxidative stress is a result of the imbalance between reactive oxygen species (ROS) and antioxidants in the body. It is a powerful mechanism that can lead to sperm damage, deformity and eventually, male infertility. This review discusses the physiological need for ROS and their role in normal sperm function. It also highlights the mechanism of production and the pathophysiology of ROS in relation to the male reproductive system and enumerate the benefits of incorporating antioxidants in clinical and experimental settings.

  15. Males and Eating Disorders

    Science.gov (United States)

    ... Bar Home Current Issue Past Issues Males and Eating Disorders Past Issues / Spring 2008 Table of Contents For ... this page please turn Javascript on. Photo: PhotoDisc Eating disorders primarily affect girls and women, but boys and ...

  16. Male Breast Cancer

    Science.gov (United States)

    ... breast cancer include exposure to radiation, a family history of breast cancer, and having high estrogen levels, which can happen with diseases like cirrhosis or Klinefelter's syndrome. Treatment for male breast cancer is usually ...

  17. Thyroid and male reproduction

    Directory of Open Access Journals (Sweden)

    Anand Kumar

    2014-01-01

    Full Text Available Male reproduction is governed by the classical hypothalamo-hypophyseal testicular axis: Hypothalamic gonadotropin releasing hormone (GnRH, pituitary luteinizing hormone (LH and follicle stimulating hormone (FSH and the gonadal steroid, principally, testosterone. Thyroid hormones have been shown to exert a modulatory influence on this axis and consequently the sexual and spermatogenic function of man. This review will examine the modulatory influence of thyroid hormones on male reproduction.

  18. Dysgenetic male pseudohermaphroditism

    OpenAIRE

    Proença, E; Freitas, S.; Fonseca, M.; Figueiredo, S; Rodrigues, C.

    2001-01-01

    Acta Med Port. 2001 Sep-Dec;14(5-6):511-4. [Dysgenetic male pseudohermaphroditism] [Article in Portuguese] Proença E, Freitas S, Fonseca M, Figueiredo S, Rodrigues C. Serviço de Cirurgia Pediátrica, Hospital Maria Pia, Porto. Abstract Dysgenetic male pseudohermaphroditism is the result of a defect of testis development that encompasses a large clinical heterogeneity. It is characterized by bilateral dysgenetic testis, absence of mullerian regression, ambiguous genitalia and/...

  19. &apos;Drooping shoulder&apos; - nontraumatic causes of glenohumeral subluxation

    Energy Technology Data Exchange (ETDEWEB)

    Lev-Toaff, A.S.; Karasick, D.; Rao, V.M.

    1984-06-01

    Nontraumatic glenohumeral subluxation can occur in patients with hemiplegia or brachial plexus involvement by tumor. Two cases of inferior subluxation of the humeral head are presented and nontraumatic etiologies of the &apos;&apos;drooping shoulder&apos;&apos; are discussed.

  20. Spanish participation in the R and D program in radiation protection within the field&apos;&apos;Safety in Nuclear Fission&apos;&apos; of ECC (1992-1993). Participacion espaola en el programa de I+D en proteccion radiologica dentro del area de &apos;&apos; Seguridad de la fision nuclear&apos;&apos; de la CEE (1992-93)

    Energy Technology Data Exchange (ETDEWEB)

    1993-01-01

    Twenty two Spanish research teams from Universities, Hospitals, Foundations, as well as CIEMAT, have received contributions from the EC of 188 million pesetas. This funding corresponds to the Program: &apos;&apos;Research in radiation protection&apos;&apos; for the period 1992-1993. The total budget of the program is 3400 million pesetas.

  1. Resource consumption of Germany - indicators and definitions. Development of a glossary on the concept of &apos;'resources'&apos; and calculation of missing characteristic data of resources consumption for further political analysis; Ressourcenverbrauch von Deutschland - aktuelle Kennzahlen und Begriffsbestimmungen. Erstellung eines Glossars zum &apos;'Ressourcenbegriff'&apos; und Berechnung von fehlenden Kennzahlen des Ressourcenverbrauchs fuer die weitere politische Analyse

    Energy Technology Data Exchange (ETDEWEB)

    Schuetz, Helmut; Bringezu, Stefan [Wuppertal Institut fuer Klima, Umwelt, Energie GmbH, Wuppertal (Germany). Forschungsgruppe 3: Stoffstroeme und Ressourcenmanagement

    2008-02-15

    The goals of the reported study are: - to prepare a glossary on the term &apos;'Resources'&apos; in order to support communication based on a harmonised resource term and associated terms and - to provide key data on resource use in Germany in time series since 1991 up to the most recent year for which data were available (2004 in general), and to attribute results to the resource terms. Results achieved are presented and discussed below by the following sections: Provision of a glossary on the term &apos;'resource'&apos;, use of the term &apos;'resource'&apos; at different levels, and provision of data and derived indicators for resource consumption in time series. First, a list of the relevant publications in the topic field &apos;'resources'&apos; was provided and co-ordinated with the client. This publication list is given in the annex to this report. On basis of national and international sources a glossary was provided which clearly describes and comments the resource term, its sub-terms and associated terms. This glossary is in the annex to this report. (orig.)

  2. Childrens&apos; Conceptions of Nature

    Science.gov (United States)

    Payne, Phillip

    2014-01-01

    This paper describes a study of sixth grade children&apos;s conceptions of nature and the environment. In so doing, it asks that environmental educators pay more attention to children&apos;s preconceived notions of environment and nature. Should this occur the theory-practice gap in environmental education may be diminished. Learners&apos; concept…

  3. The Novel SCN&apos;&apos;- Ion-selective Electrode Based on the 1-Benzyl-3-(4-nitrophenyl) thio-urea Ionophore

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyung Mi; Kang, Dong Hyeon; Choe, Ju Eun; You, Jung Min; Go, Min Jeong; Lee, Jung Seong; Jeon, Seung Won [Chungnam National University, Daejeon (Korea, Republic of)

    2014-09-15

    A potentiometric sensor based on the 1-benzyl-3-(4-nitrophenyl) thio-urea was synthesized and tested as an ionophore in PVC based membrane sensor towards SCN - ions. This membrane exhibits a linear stable response over a wide concentration range (1.0 × 10&apos;&apos;-5 to 1.0 × 10&apos;&apos;-2 M) with a slope of -59.2 mV/dec., a detection limit of log[SCN&apos;&apos;- ] = -5.05, and a selectivity coefficient for thiocyanate against perchlorate anion of logK{sub s}cn&apos;&apos;pot = -0.133. The selectivity series of the membrane is as follows: SCN&apos;&apos;- > ClO{sub 4}&apos;&apos;- > I&apos;&apos;- >NO{sub 3}&apos;&apos;- >HSO{sub 3}&apos;&apos;- > Cl&apos;&apos;-HSO{sub &apos;}'-'&apos;4 > F&apos;&apos;- > CH{sub 3}COO&apos;&apos;- > HCO&apos;'-'&apos;3 > Br&apos;&apos;- > H{sub 2}PO{sub 4}&apos;&apos;- > SO{sub 3}&apos;'-'&apos;2 > SO{sub 4}&apos;'-'&apos;2 > CO{sub 3}&apos;'-'&apos;2. The proposed electrode showed good selectivity and a good response for the SCN&apos;&apos;- ion over a wide variety of other anions in pH 6.0 buffer solutions and has a fast response time of about < 5s.. The influences of the membrane by pH, ionophore, and plasticizer were studied.

  4. Introducing Human APOE into Aβ Transgenic Mouse Models

    Directory of Open Access Journals (Sweden)

    Leon M. Tai

    2011-01-01

    Full Text Available Apolipoprotein E (apoE and apoE/amyloid-β (Aβ transgenic (Tg mouse models are critical to understanding apoE-isoform effects on Alzheimer's disease risk. Compared to wild type, apoE−/− mice exhibit neuronal deficits, similar to apoE4-Tg compared to apoE3-Tg mice, providing a model for Aβ-independent apoE effects on neurodegeneration. To determine the effects of apoE on Aβ-induced neuropathology, apoE−/− mice were crossed with Aβ-Tg mice, resulting in a significant delay in plaque deposition. Surprisingly, crossing human-apoE-Tg mice with apoE−/−/Aβ-Tg mice further delayed plaque deposition, which eventually developed in apoE4/Aβ-Tg mice prior to apoE3/Aβ-Tg. One approach to address hAPOE-induced temporal delay in Aβ pathology is an additional insult, like head injury. Another is crossing human-apoE-Tg mice with Aβ-Tg mice that have rapid-onset Aβ pathology. For example, because 5xFAD mice develop plaques by 2 months, the prediction is that human-apoE/5xFAD-Tg mice develop plaques around 6 months and 12 months before other human-apoE/Aβ-Tg mice. Thus, tractable models for human-apoE/Aβ-Tg mice continue to evolve.

  5. Conference: &apos;Heating with Wood&apos;. An alternative to fossil fuels? Status and perspectives. Documentation; Tagung: &apos;Heizen mit Holz&apos;. Eine Alternative zur fossilen Energie? Stand der Technik und neue Perspektiven. Dokumentation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    Main topics of the meeting &apos;&apos;Heating with wood&apos;&apos; were: resource assessment, economical aspects, logistics, cogeneration, district heating, plantation and harvesting of fast growing trees, new heating systems.(uke)

  6. Reply to &apos;Noether&apos;s theorem once again&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Marinho, Rubens M Jr [Departamento de Fisica, Instituto Tecnologico de Aeronautica (Brazil)], E-mail: marinho@ita.br

    2009-09-15

    This reply answers the issues raised in the comment on my paper (Marinho Jr 2007 Eur. J. Phys. 28 37-43), obtains the Laplace-Runge-Lenz vector (Goldstein 2002 Classical Mechanics 3rd edn (Reading, MA: Addison-Wesley)) using Noether&apos;s theorem and includes a Maple program used to derive the results. (letters and comments)

  7. Chronic radiation effects on dental hard tissue (&apos;&apos;radiation carries&apos;&apos;). Classification and therapeutic strategies; Chronische Strahlenfolgen an den Zahnhartgeweben (&apos;'Strahlenkaries'&apos;). Klassifikation und Behandlungsansaetze

    Energy Technology Data Exchange (ETDEWEB)

    Groetz, K.A.; Brahm, R.; Al-Nawas, B.; Wagner, W. [Universitaetsklinik und Poliklinik fuer Mund-, Kiefer- und Gesichtschirurgie, Mainz (Germany); Riesenbeck, D.; Willich, N. [Universitaetsklinik und Poliklinik fuer Strahlentherapie -Radioonkologie, Muenster (Germany); Seegenschmiedt, M.H. [Alfried-Krupp-Krankenhaus Essen (Germany). Klinik und Poliklinik fuer Radioonkologie, Strahlentherapie und Nuklearmedizin; Doerr, W. [Technische Univ. Dresden (Germany). Klinik und Poliklinik fuer Strahlentherapie und Radioonkologie; Kutzner, J.; Thelen, M. [Universitaetsklinik und Poliklinik fuer Radiologie/Strahlentherapie, Mainz (Germany)

    2001-02-01

    Objectives: Since the first description of rapid destruction of dental hard tissues following head and neck radiotherapy 80 years ago, &apos;radiation caries&apos; is an established clinical finding. The internationally accepted clinical evaluation score RTOG/EORTC however is lacking a classification of this frequent radiogenic alteration. Material and Methods: Medical records, data and images of radiation effects on the teeth of more than 1,500 patients, who underwent periradiotherapeutic care, were analyzed. Macroscopic alterations regarding the grade of late lesions of tooth crowns were used for a classification into 4 grades according to the RTOG/EORTC guidelines. Results: No early radiation effects were found by macroscopic inspection. In the first 90 days following radiotherapy 1/3 of the patients complained of reversible hypersensitivity, which may be related to a temporary hyperemia of the pulp. It was possible to classify radiation caries as a late radiation effect on a graded scale as known from RTOG/EORTC for other organ systems. This is a prerequisite for the integration of radiation caries into the international nomenclature of the RTOG/EORTC classification. Conclusions: The documentation of early radiation effects on dental hard tissues seems to be neglectable. On the other hand the documentation of late radiation effects has a high clinical impact. The identification of an initial lesion at the high-risk areas of the neck and incisal part of the tooth can lead to a successful therapy as a major prerequisite for orofacial rehabilitation. An internationally standardized documentation is a basis for the evaluation of the side effects of radiooncotic therapy as well as the effectiveness of protective and supportive procedures. (orig.) [German] Fragestellung: Die rasche Zahnhartgewebszerstoerung nach einer Kopf-Hals-Bestrahlung wurde bereits vor fast 80 Jahren als &apos;Strahlenkaries&apos; beschrieben und ist seither als klinischer Befund in der Routine

  8. Putting &apos;international&apos; back in IPEC.

    Energy Technology Data Exchange (ETDEWEB)

    Veil, J. A.

    2000-10-27

    During the previous six annual sessions of the International Petroleum Environmental Conference (IPEC), little attention has been given to international issues. Although the US is clearly a leader in oil field research and regulatory development information is available on interesting projects throughout the world Many participants in IPEC have little exposure to international oil and gas environmental problems and solutions. Beginning with the 7th IPEC, a stronger effort is being made to include international issues in the confidence. This paper describes some of the author&apos;s experiences in working with international oil and gas environmental issues in North America, Latin America, Europe, and Asia. Among the topics to be discussed are the issues that developing oil and gas-producing nations face and the need for sensitivity to other nation&apos;s cultures and legal systems.

  9. A cool &apos;win-win&apos; for Matra

    Energy Technology Data Exchange (ETDEWEB)

    Wolff, V. [Alstom, Budapest (Hungary)

    2007-07-15

    In 2004 the Matra plant management initiated a 60 M euro investment programme to increase the generating capacity of units 4 and 5 of the lignite fuelled plant and to give it greater flexibility. This has been achieved by adding a 30 MW natural gas-fired topping gas turbine to each of the 230 MW units, for commissioning by 2007. The power uprate meant the capacity of the dry-tower based cooling system was increased by 24 W for each unit. This has now undergone a major upgrade, involving addition of a wet cooling tower to create a &apos;hybrid&apos; system. It is one of the largest such projects ever carried out, and the first involving a dry-tower cooling system of the Heller type. The result is increased competitiveness and efficiency, with a 250,000 t reduction in annual carbon dioxide emissions. 3 figs.

  10. Environmental education project &apos;Mico-Estrela Track&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Vicente, Ana Paula Camargo de; Magalhaes, Milton Pinto Magalhaes; Silva, Simone Rodrigues da; Pinheiro, Roberta Vieira Nunes; Torres, Carlos Alberto Rodrigues; Silveira, Jeanete [PETROBRAS Transporte S.A. (TRANSPETRO), Rio de Janeiro, RJ (Brazil)

    2009-12-19

    Senador Canedo fuel storage terminal is situated in the Cerrado biome and implements the policy of promoting improvements in the preservation of its Green Belt by working out the Environmental Education Project &apos;Mico-Estrela7 Track&apos;, aimed at stimulating the preservation, protection, landscape beauty and defense of scientific sources of the Cerrado through environmental sensibilization and rational use of the existing natural resources. In the area of the track (1.5 ha) alone 352 plants have been identified, totaling 97 different species that are distributed in 36 families. The implementation of the project will contribute to strengthen the relations with the local community, like dwellers, teachers and pupils of the municipal network of Senador Canedo, as well as co-workers of the unit, thus reaffirming the commitment of the company to socio-environmental responsibility. (author)

  11. Cervical spine involvements in Reiter&apos;s syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Moilanen, A.; Yli-Kerrtula, U.; Vippula, A.

    1984-07-01

    Cervical spine radiographs of 38 patients orginating from 145 consecutive cases with Reiter&apos;s syndrome (RS) were reviewed. Five of these 145 patients (3.4%) had cervical spine manifestations: anterior atlanto-axial dislocation 2, craniovertebral lesions typical for rhreumatoid arthritis (RA), spondylitis typical for ankylosing spondylitis (AS) and anterior ossification, one each. Four of these patients were males. Cervical lesions in RS turned out to be rare. These lesions are alone indistinguisable from those of other chronic rheumatic inflammatory diseases.

  12. Reduced Metabolsim in Brain &apos;Control Networks&apos; Following Cocaine-Cues Exposure in Female Cocaine Abusers

    Energy Technology Data Exchange (ETDEWEB)

    Volkow, N.D.; Wang, G.; Volkow, N.D.; Tomasi, D.; Wang, G.-J.; Fowler, J.S.; Telang, F.; Goldstein, R.Z.; Alia-Klein, N.; Wong, C.T.

    2011-03-01

    Gender differences in vulnerability for cocaine addiction have been reported. Though the mechanisms are not understood, here we hypothesize that gender differences in reactivity to conditioned-cues, which contributes to relapse, are involved. To test this we compared brain metabolism (using PET and {sup 18}FDG) between female (n = 10) and male (n = 16) active cocaine abusers when they watched a neutral video (nature scenes) versus a cocaine-cues video. Self-reports of craving increased with the cocaine-cue video but responses did not differ between genders. In contrast, changes in whole brain metabolism with cocaine-cues differed by gender (p<0.05); females significantly decreased metabolism (-8.6% {+-} 10) whereas males tended to increase it (+5.5% {+-} 18). SPM analysis (Cocaine-cues vs Neutral) in females revealed decreases in frontal, cingulate and parietal cortices, thalamus and midbrain (p<0.001) whereas males showed increases in right inferior frontal gyrus (BA 44/45) (only at p<0.005). The gender-cue interaction showed greater decrements with Cocaine-cues in females than males (p<0.001) in frontal (BA 8, 9, 10), anterior cingulate (BA 24, 32), posterior cingulate (BA 23, 31), inferior parietal (BA 40) and thalamus (dorsomedial nucleus). Females showed greater brain reactivity to cocaine-cues than males but no differences in craving, suggesting that there may be gender differences in response to cues that are not linked with craving but could affect subsequent drug use. Specifically deactivation of brain regions from &apos;control networks&apos; (prefrontal, cingulate, inferior parietal, thalamus) in females could increase their vulnerability to relapse since it would interfere with executive function (cognitive inhibition). This highlights the importance of gender tailored interventions for cocaine addiction.

  13. Scientists from all over the world attend the &apos;&apos;Frederic Joliot/Otto Hahn Summer School 2009&apos;&apos; at the Karlsruhe Institute of Technology (KIT); Wissenschaftler aus aller Welt bei der &apos;&apos;Frederic Joliot/Otto Hahn Summer School 2009&apos;&apos; am Karlsruhe Institute of Technologie (KIT)

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez Espinoza, Victor Hugo; Fischer, Ulrich [Karlsruhe Inst. of Tech. (KIT), Campus Nord/Inst. for Neutron Physics and Reactor Tech. (INR), Eggenstein-Leopoldshafen (Germany)

    2009-11-15

    The &apos;&apos;Frederic Joliot/Otto Hahn Summer School&apos;&apos; is organized each year alternately by the Karlsruhe Institute of Technology and the Commissariat a l&apos;Energie Atomique (CEA), Cadarache. This year&apos;s Summer School, the 15th since its foundation, was run at the Advanced Training Center (FTU) of KIT Campus Nord on August 26 to September 4. The key topic this year was &apos;&apos;The Challenges in Implementing Fast Reactor Technology.&apos;&apos; These are the items discussed: Principles and challenges of future fast reactor designs, Fuels, fuel cycle, and recycling of minor actinides, Innovative cladding tube and structural materials, Special aspects of coolants and the challenges they pose, Fast reactor safety. Experts from 8 leading international research establishments and universities presented and discussed with the 58 participants from 16 countries the current state of the art and the latest development trends in the topics listed above. (orig.)

  14. ApoB/ApoA-1 ratio and nitric oxide levels in pregnancy induced hypertensive women

    Directory of Open Access Journals (Sweden)

    Visala Sree Jammalamadaga

    2016-05-01

    Results: The SBP and DBP were significantly high between 3 groups. The mean plasma TC, TGL, VLDL, LDL, MDA, ApoB levels, ApoB/ApoA-I were significantly high and HDL, ApoA-I, NO, FRAP levels were significantly low between 3 groups. The ApoB/ApoA-I was positively correlated with TC, TGL, VLDL, LDL, malondialdehyde and negatively correlated with HDL, FRAP and NO. Conclusions: Our results indicate that women with PE and E exhibit markedly elevated concentrations of TGL-rich lipoproteins. The negative correlation between ApoB/ApoA-I with NO indicates that the hyperlipidemia is directly related with severity of ED in PIH. So, careful monitoring of ApoB/ApoA-I along with NO might be helpful to predict the onset and progression of the disease. [Int J Res Med Sci 2016; 4(5.000: 1329-1334

  15. &apos;Minergie&apos; modernisation - Test in practice; Praxistest Minergie-Modernisierung

    Energy Technology Data Exchange (ETDEWEB)

    Ruetter, H.; Ruetter-Fischbacher, U. [Ruetter und Partner, Soziooekonomische Forschung und Beratung, Rueschlikon (Switzerland); Haessig, W. [Haessig Sustech GmbH - Ingenieurbuero fuer Minergie und nachhaltige Gebaeudetechnik, Uster (Switzerland); Jakob, M. [TEP Energy GmbH, CEPE ETH, Zuerich (Switzerland)

    2008-07-01

    This comprehensive report for the Swiss Federal Office of Energy (SFOE) examines the results obtained in practice concerning the use of the &apos;Minergie&apos; low energy consumption standard. Experience gained with &apos;Minergie&apos; refurbishment projects is reviewed and the critical points and constraints found are discussed. Further, recommendations for improvements in the use of the &apos;Minergie&apos; standard are made. The study is based on questions posed to building owners in the German speaking part of Switzerland who have carried out refurbishment projects to meet &apos;Minergie&apos; standards as well as questions posed to those who did not adhere to &apos;Minergie&apos; standards in the refurbishment of their buildings. The reasons quoted for using / not using the standard are listed and discussed. Possible tightening of energy regulations concerning renovation work are discussed. The recommendations resulting from the survey are also noted and discussed.

  16. Photoluminescence of acupoint &apos;Waiqiu&apos; in human superficial fascia

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Yuan [Synchrotron Radiation Research Center, Department of Physics, Surface Physics Laboratory (State Key Laboratory) of Fudan University, Shanghai 200433 (China); Yan Xiaohui [Synchrotron Radiation Research Center, Department of Physics, Surface Physics Laboratory (State Key Laboratory) of Fudan University, Shanghai 200433 (China); Liu Chenglin [Synchrotron Radiation Research Center, Department of Physics, Surface Physics Laboratory (State Key Laboratory) of Fudan University, Shanghai 200433 (China); Dang Ruishan [Second Military Medical University, Shanghai 200433 (China); Zhang Xinyi [Synchrotron Radiation Research Center, Department of Physics, Surface Physics Laboratory (State Key Laboratory) of Fudan University, Shanghai 200433 (China) and Shanghai Research Center of Acupuncture and Meridian, Pudong, Shanghai 201203 (China)]. E-mail: xy-zhang@fudan.edu.cn

    2006-07-15

    The spectral characters of an acupuncture point named &apos;Waiqiu&apos; in superficial fascia tissue have been studied by photoluminescence (PL) spectroscopy under the excitation of 457.9 nm. The PL around &apos;Waiqiu&apos; acupuncture point consists of two sub-bands resulting from the flavin adenine dinucleotide (FAD) and phospholipids, and the porphyrins (including purine, isoxanthopterin and tryptophan), respectively. More emission due to FAD and phospholipids is found inside the acupuncture effect area of &apos;Waiqiu&apos; than its marginal or outside acupuncture regions. The ratio of emission intensity of FAD and phospholipids to one of porphyrins gradually decreases along the direction away from the center of the acupuncture point. It implies that the component proportion changes between FAD, phospholipids and porphyrins around the &apos;Waiqiu&apos; acupuncture point. We suggest that there might be a certain relationship between redox function of FAD and &apos;Waiqiu&apos; acupuncture effect.

  17. Finishing report for the &apos;SolcelleInverter&apos; project

    Energy Technology Data Exchange (ETDEWEB)

    Boekhoej Kjaer, S.

    2005-03-01

    The main objective for this research project was to develop an inverter for the AC module, where one PV module is equipped with its own dedicated inverter, and connected to the grid. A topology, among many different candidates, has been selected, based on analysis&apos;s. The inverter has been optimized in respect to cost, reliability, and efficiency, and a prototype has been build. (au)

  18. MRI of &apos;brain death&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Nishino, Shigeki; Itoh, Takahiko; Tuchida, Shohei; Kinugasa, Kazushi; Asari, Shoji; Nishimoto, Akira (Okayama Univ. (Japan). School of Medicine); Sanou, Kazuo

    1990-12-01

    Magnetic resonance imaging (MRI) was undertaken for two patients who suffered from severe cerebrovascular diseases and were clinically brain dead. The MRI system we used was Resona (Yokogawa Medical Systems, superconductive system 0.5 T) and the CT apparatus was Toshiba TCT-300. Initial CT and MRI were undertaken as soon as possible after admission, and repeated sequentially. After diagnosis of brain death, we performed angiography to determine cerebral circulatory arrest, and MRI obtained at the same time was compared with the angiogram and CT. Case 1 was a 77-year-old man who was admitted in an unconscious state. CT and MRI on the second day after hospitalization revealed cerebellar infarction. He was diagnosed as brain dead on day 4. Case 2 was a 35-year-old man. When he was transferred to our hospital, he was in cardiorespiratory arrested. Cardiac resuscitation was successful but no spontaneous respiration appeared. CT and MRI on admission revealed right intracerebral hemorrhage. Angiography revealed cessation of contrast medium in intracranial vessels in both of the patients. We found no &apos;flow signal void sign&apos; in the bilateral internal carotid and basilar arteries on MRI images in both cases after brain death. MRI, showing us the anatomical changes of the brain, clearly revealed brain herniations, even though only nuclear findings of &apos;brain tamponade&apos; were seen on CT. But in Case 1, we could not see the infarct lesions in the cerebellum on MR images obtained after brain death. This phenomenon was caused by the whole brain ischemia masking the initial ischemic lesions. We concluded that MRI was useful not only the anatomical display of lesions and brain herniation with high contrast resolution but for obtaining information on cerebral circulation of brain death. (author).

  19. MR findings of large schmorl&apos;s nodes

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Wook; Lee, Seung Ik [Pundang CHA Hospital, Sungnam (Korea, Republic of)

    1998-10-01

    To demonstrate the MR findings of large Schmorl&apos;s nodes(>1cm). Six hundred patients underwent MRI and the results were retrospectively analysed. Eleven patients(1.83%) had 12 large Schmorl&apos;s nodes. We analyzed the size, contour, location, signal changes and enhancement of these, as well as marrow changes in adjacent vertebral bodies. Twelve large Schmorl&apos;s nodes were found in eleven of 600 patients(1.83%) with a mean age of 46.1 years and a female:male ratio of 4:7. Their mean size was 1.35cm(AP)x0.99cm(height)x1.23cm(transverse), and they were observed at various sites, namely lower(n=3D7) and upper end-plate locations(n=3D5). Central locations(n=3D8) on end-plates were most common. A semi-lunar appearance was noted in seven cases, and in most , a well-demarcated irregular margin was seen. All large Schmorl&apos;s nodes were enhanced;peripheral forms(n=3D8) were more common than diffuse(n=3D4). Adjacent discs showed no intranuclear enhancement but in seven cases there was flat-contoured enhancements in the annulus fibrosus. In disks with large Schmorl&apos;s nodes, degeneration was noted on T2WI regardless of the degree of diskal herniation. In nearly all cases, signal intensity on T1WI was low, but on T2WI, this was variable. Large Schmorl&apos;s nodes showed characteristic marrow change in adjacent vertebral bodies;the most common pattern was fatty and sclerotic(n=3D8). Especially on T1-weighted axial images, target appearances were visible in ten cases. MR findings of Schmorl&apos;s nodes will be very useful for differentiating nodes from other vertebral or diskal lesions, especially spondylitis combined with diskitis or vertebral body tumor.=20.

  20. Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study.

    Directory of Open Access Journals (Sweden)

    Laurence O'Dwyer

    Full Text Available The E4 allele of the ApoE gene has consistently been shown to be related to an increased risk of Alzheimer's disease (AD. The E4 allele is also associated with functional and structural grey matter (GM changes in healthy young, middle-aged and older subjects. Here, we assess volumes of deep grey matter structures of 22 healthy younger ApoE4 carriers and 22 non-carriers (20-38 years. Volumes of the nucleus accumbens, amygdala, caudate nucleus, hippocampus, pallidum, putamen, thalamus and brain stem were calculated by FMRIB's Integrated Registration and Segmentation Tool (FIRST algorithm. A significant drop in volume was found in the right hippocampus of ApoE4 carriers (ApoE4+ relative to non-carriers (ApoE4-, while there was a borderline significant decrease in the volume of the left hippocampus of ApoE4 carriers. The volumes of no other structures were found to be significantly affected by genotype. Atrophy has been found to be a sensitive marker of neurodegenerative changes, and our results show that within a healthy young population, the presence of the ApoE4+ carrier gene leads to volume reduction in a structure that is vitally important for memory formation. Our results suggest that the hippocampus may be particularly vulnerable to further degeneration in ApoE4 carriers as they enter middle and old age. Although volume reductions were noted bilaterally in the hippocampus, atrophy was more pronounced in the right hippocampus. This finding relates to previous work which has noted a compensatory increase in right hemisphere activity in ApoE4 carriers in response to preclinical declines in memory function. Possession of the ApoE4 allele may lead to greater predilection for right hemisphere atrophy even in healthy young subjects in their twenties.

  1. &apos;&apos;Confession statement against the nuclear nation&apos;&apos;. The protestant church in Germany and the conflicts concerning nuclear energy 1970 - 1990; &apos;&apos;Bekennen gegen den Atomstaat&apos;&apos;. Die evangelischen Kirchen in der Bundesrepublik Deutschland und die Konflikte um die Atomenergie 1970-1990

    Energy Technology Data Exchange (ETDEWEB)

    Schuering, Michael [Florida Univ., Gainesville, FL (United States)

    2015-07-01

    The book on &apos;&apos;Confession statement against the nuclear nation&apos;&apos; discusses the conflicts of the protestant church in Germany concerning nuclear energy in 1970 - 1990. The introduction covers the state of research and the historical sources. The following chapters discuss the issues philosophic-ideological fundamentals: atomic energy and theology, the political church, the new protest culture and comparative perspectives: the catholic perspective, Three Mile Island&apos;s shadow.

  2. Behavioral phenotype and BDNF differences related to apoE isoforms and sex in young transgenic mice

    DEFF Research Database (Denmark)

    Reverte, Ingrid; Klein, Anders Bue; Ratner, Cecilia;

    2012-01-01

    , very little information is available on apoE2 genotype. In the present study, we have characterized behavioral and learning phenotypes in young transgenic mice apoE2, apoE3 and apoE4 of both sexes. We have also determined the levels of brain-derived neurotrophic factor (BDNF) and its receptor Trk...... in the exploration of an open-field, which is compatible with a hyperactive behavior, was found in apoE2 females, while a decreased activity was observed in apoE4 mice. Increased BDNF levels in the frontal cortex were observed in apoE2 mice compared to apoE3. These results underscore behavioral differences between...

  3. Energy-related renovation in the world heritage. Retrofitting &apos;Glas-Hoffmann&apos; buildings, Berlin; Energetische Sanierung im Weltkulturerbe. Sanierung &apos;Glas-Hoffmann&apos;-Bauten, Berlin

    Energy Technology Data Exchange (ETDEWEB)

    Brensing, Christian

    2012-11-01

    Between 1955 and 1959, the housing estate at the Schiller park in Berlin-Wedding (Federal Republic in Germany) established in the 1920ies was expanded by four-storey house lines, the so-called Glas-Hoffmann buildings. Since 2008, this ensemble belongs to the Unesco World Heritage. In improving the thermal insulation of the building envelope and the adaptation of the building services to today&apos;s standards, therefore the architectural aesthetics of these buildings should not be endangered. The retrofitting was a pilot project of the research project &apos;&apos;Monument and energy - Postwar Modernism&apos;&apos;.

  4. Functional and morphological parameters with tissue characterization of cardiovascular magnetic imaging in clinically verified &apos;&apos;infarct-like myocarditis&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Schwab, Johannes [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Cardiology and Radiology; Rogg, H.J.; Pauschinger, M.; Fessele, K. [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Cardiology; Bareiter, T.; Baer, I. [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Cardiology and Neuroradiology; Loose, R. [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Radiology

    2016-04-15

    Cardiac magnetic resonance (CMR) has increasingly proved to be a valuable diagnostic tool for evaluating patients with suspected myocarditis. The objective of this study was to evaluate the diagnostic value of functional and morphological parameters including tissue characterization in patients with &apos;&apos;infarct-like myocarditis&apos;&apos;. 43 patients with clinically verified cases of &apos;&apos;infarct-like myocarditis&apos;&apos; (median time to MRI scanning after admission for acute symptoms 3 days) and 35 control patients matched by age and sex were included in this retrospective case control study. In this study we used a 1.5 T MRI scanner conducting steady-state-free-precession sequences, T2-weighted imaging, T1-weighted imaging before and after contrast administration and late gadolinium enhancement sequences. According to the recommendations for CMR diagnosis of myocarditis (Lake Louise consensus criteria), a scan was positive for acute myocarditis if 2 of 3 CMR criteria were present. 30 % of the patients with &apos;&apos;infarct-like myocarditis&apos;&apos; had a reduced left ventricular ejection fraction, 11 % had an increased LV end-diastolic volume index and 35 % had an increased LV mass index. The sensitivity of wall motion abnormalities was 63 % with a regional distribution in 49 %. In 47 % of cases regional wall motion abnormalities were present in the lateral left ventricular segments. Pericardial effusions were discovered in 65 % of cases with a circular appearance in 21 % and focal manifestation in 44 %. The diagnostic sensitivity, specificity, and accuracy of CMR in patients with &apos;&apos;infarct-like myocarditis&apos;&apos; were 67 %, 100 % and 82 %, respectively. The LGE alone was the most sensitive test parameter with 86 %, providing a specificity of 100 % and accuracy of 92 %. Our study results can be applied to the subgroup of patients with &apos;&apos;infarct-like myocarditis&apos;&apos;, where we found that LGE alone was the

  5. Solar students&apos; hostel at Kaiserslautern

    Energy Technology Data Exchange (ETDEWEB)

    Hoffmann, W.; Vangerow-Kuehn, A.

    A students&apos; hostel including 30 living units is being built at the University of Kaiserslautern. Together with the department of biology the students of the department of architecture, regional and environmental planning, civil engineering, are planning an &apos;'alternative'&apos; hostel. It is to be constructed on the university campus in self-construction. The passive utilization of solar energy for the conservation of heating costs is focused in the design planning. The hostel shall be roofed with a standard, low-priced greenhouse construction of a prefabrication degree of 100% and including standardized ventilation devices and blinds.

  6. The location selection act or &apos;the Emperor&apos;s new clothes&apos;; Das Standortauswahlgesetz oder &apos;Des Kaisers neue Kleider&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Feldmann, Ulrike

    2013-10-15

    As is generally known, the governing parties CDU/CSU and FDP agreed a few weeks ago in the 17{sup th} legislative period of the German Bundestag in a rare show of unanimity, together with the parties SPD and Buendnis 90/Die Gruenen, as well as with the Laender, on a &apos;law to search and select a location for a permanent disposal site for heat-generating radioactive waste products and to change other laws&apos;, in brief a location selection act also called StandAG. The law was received with animated approval from the ranks of the parties - with the exception of the (left-wing) party Die Linke. This praise is a tad bewildering, since the Bundesumweltministerium (Federal Department of the Environment) named solving the task within a single generation as one of the principles for the StandAG, and it was emphasised again and again in the debates about the StandAG that the problem of permanent disposal must not be shifted to the next generation. Conclusion: - The StandAG leads to a postponement of solving the permanent disposal site issue by a least several generations with its predictable, long-winded selection method. - The decision not to explore Gorleben conclusively could lead to the site being permanently (&apos;wasted&apos; or) &apos;burned&apos;. - The de-central, interim disposal site Gorleben is likewise &apos;burned&apos; without having a resilient alternative solution for the glass coquilles that must be taken back. - The people&apos;s protest is exponentiated by the number of the potential sites for the StandAG. - The costs for the alternative site search will not be shifted to the producers of the waste that are obliged by law to deliver the waste because of the financial provisions of the constitution. - The third party protection dogma has not been broken up, which will at least lead to delays in the procedure and will have effects on other major projects in the long run. (orig.)

  7. Evaluatie onderzoeksprogramma&apos;s milieutechnologie vanuit een invalshoek stoffen

    NARCIS (Netherlands)

    Lijzen JPA

    1991-01-01

    This study was carried out to determine the need of a separate programme of the &apos;Regulation for the Advancement of Environmental Technology&apos; (&apos;Sti-MT&apos;) to stimulate technology from a substance point of view. Therefore 6 programms of the &apos;Sti-MT&apos; and 5 other technologic

  8. The intern structure of special relativity; La &apos;&apos;structure fine&apos;&apos; de la relativite restreinte

    Energy Technology Data Exchange (ETDEWEB)

    Pierseaux, Y. [Universite Libre de Bruxelles (Belgium)

    1999-07-01

    The author presents the forgotten fact that in 1905 there were 2 restricted theories of relativity: that of Einstein and that of Poincare. These 2 theories were independently formulated, they are very close to each other but are fundamentally different when we consider their basic principles. Poincare&apos;s theory is based on a classical representation of the purely undulatory aspect of light, whereas Einstein stipulates for the quantum aspect of light. Poincare&apos;s theory implies the existence of the ether and asserts the primacy of continuity over discontinuity. The author has based his work on a thorough study of the scientific articles in which Poincare and Einstein explained their ideas. The comparison of these 2 theories sheds light on the evolution of concepts on which the whole modern physics is based. An extended bibliography of works published on special relativity or on related topics is given. (A.C.)

  9. Do &apos;&apos;surrogate emissions&apos;&apos; constitute in-built leakage of the Kyoto Protocol flexible mechanisms?

    Energy Technology Data Exchange (ETDEWEB)

    Kopolo, G.

    2001-11-01

    &apos;Surrogate emissions&apos; is a neologism coined to describe GHG emissions resulting from the production of intermediate goods in developing countries for industrial processing in industrialized countries, especially where the same transnational corporation controls these goods. Where upstream industrial processes extend to other developed countries, the leakage caused by this phenomenon does not arise. This is because all developed countries have QELROs. Thus, all emissions take place within the Annex I area and are covered by the QELROs. However, where the upstream processes ramify into developing countries, the associated GHG emissions are vented off, as it were, into an open system. The paper suggests that, for a complete picture of GHG emissions resulting from the industrial activities of Annex I Parties to the UNFCCC, these surrogated emissions should be incorporated into their national inventories. Otherwise, the emissions trading scheme under the auspices of the Kyoto Protocol would be undermined. (Author)

  10. 龙陵县草果丰产栽培试验%High-yield Cultivation of Amomum Tsao-ko in Longling

    Institute of Scientific and Technical Information of China (English)

    张永弼

    2011-01-01

    选用不同遮荫度与有无常流水的种植地块、不同种子处理方法以及不同种子品种进行草果丰产栽培试验.结果表明,选用纺锤形或卵圆形、个大、粒多、成熟度高的农家种子进行播种育苗能提高草果的产量与品质;在播种前要先用草木灰或钙镁磷对革果种子进行拌种,然后用手充分搓揉,除去种子表面的胶质丝状膜,这样可保证有较高的出芽率;种植地应选择海拔1200~1800m、遮荫度为60%~70%的林下、常年有流水的山洼地块;每年冬季收果后及次年的春季进行一次追肥,花期喷施硼砂和蜂蜜液,能有效提高草果坐花坐果率.%Using planting land with different shading and with or without perennial water, with different seed treatments and different seed varieties, Amomum Tsao-ko high yield cultivation technologies experiment was conducted. The results show that the selection of spindle-shaped or oval, big, more grains,high mature local farm seeds for sowing can increase yield and quality. Before planting, using plant ash,or calcium and magnesium phosphate on the Amomum Tsao-ko seeds, then fully rub them with hands,remove the glial filaments film off seed surface, it will ensure a higher sprouting rate. The cultivation land should be selected at valley land by altitude 1 200 ~ 1 800 m, shading was 60% to 70% under forest,with perennial water. Fertilizing after fruit collection every winter and in the spring the following year,spraying solution of borax and honey during flowering, can improve the rate of Amomum Tsao- ko fruit sat.

  11. Young physicists&apos; forum

    Energy Technology Data Exchange (ETDEWEB)

    T. Adams et al.

    2001-11-02

    The Young Physicists&apos; Forum was an opportunity for the younger members of the particle-physics community to gather at Snowmass 2001 and to study and debate major issues that face the field over the next twenty years. Discussions were organized around three major topics: outreach and education, the impact of globalization, and building a robust and balanced field. We report on the results of these discussions, as presented on July 17, 2001.

  12. Development of new VOC exposure metrics and their relationship to &apos;&apos;Sick Building Syndrome&apos;&apos; symptoms

    Energy Technology Data Exchange (ETDEWEB)

    Ten Brinke, JoAnn [Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab., Berkeley, CA (United States)

    1995-08-01

    Volatile organic compounds (VOCs) are suspected to contribute significantly to &apos;&apos;Sick Building Syndrome&apos;&apos; (SBS), a complex of subchronic symptoms that occurs during and in general decreases away from occupancy of the building in question. A new approach takes into account individual VOC potencies, as well as the highly correlated nature of the complex VOC mixtures found indoors. The new VOC metrics are statistically significant predictors of symptom outcomes from the California Healthy Buildings Study data. Multivariate logistic regression analyses were used to test the hypothesis that a summary measure of the VOC mixture, other risk factors, and covariates for each worker will lead to better prediction of symptom outcome. VOC metrics based on animal irritancy measures and principal component analysis had the most influence in the prediction of eye, dermal, and nasal symptoms. After adjustment, a water-based paints and solvents source was found to be associated with dermal and eye irritation. The more typical VOC exposure metrics used in prior analyses were not useful in symptom prediction in the adjusted model (total VOC (TVOC), or sum of individually identified VOCs (ΣVOCi)). Also not useful were three other VOC metrics that took into account potency, but did not adjust for the highly correlated nature of the data set, or the presence of VOCs that were not measured. High TVOC values (2--7 mg m-3) due to the presence of liquid-process photocopiers observed in several study spaces significantly influenced symptoms. Analyses without the high TVOC values reduced, but did not eliminate the ability of the VOC exposure metric based on irritancy and principal component analysis to explain symptom outcome.

  13. Development of new VOC exposure metrics and their relationship to &apos;&apos;Sick Building Syndrome&apos;&apos; symptoms

    Energy Technology Data Exchange (ETDEWEB)

    None

    1995-08-01

    Volatile organic compounds (VOCs) are suspected to contribute significantly to &apos;&apos;Sick Building Syndrome&apos;&apos; (SBS), a complex of subchronic symptoms that occurs during and in general decreases away from occupancy of the building in question. A new approach takes into account individual VOC potencies, as well as the highly correlated nature of the complex VOC mixtures found indoors. The new VOC metrics are statistically significant predictors of symptom outcomes from the California Healthy Buildings Study data. Multivariate logistic regression analyses were used to test the hypothesis that a summary measure of the VOC mixture, other risk factors, and covariates for each worker will lead to better prediction of symptom outcome. VOC metrics based on animal irritancy measures and principal component analysis had the most influence in the prediction of eye, dermal, and nasal symptoms. After adjustment, a water-based paints and solvents source was found to be associated with dermal and eye irritation. The more typical VOC exposure metrics used in prior analyses were not useful in symptom prediction in the adjusted model (total VOC (TVOC), or sum of individually identified VOCs ({Sigma}VOC{sub i})). Also not useful were three other VOC metrics that took into account potency, but did not adjust for the highly correlated nature of the data set, or the presence of VOCs that were not measured. High TVOC values (2--7 mg m{sup {minus}3}) due to the presence of liquid-process photocopiers observed in several study spaces significantly influenced symptoms. Analyses without the high TVOC values reduced, but did not eliminate the ability of the VOC exposure metric based on irritancy and principal component analysis to explain symptom outcome.

  14. CT angiography helps to differentiate acute from chronic carotid occlusion: the &apos;&apos;carotid ring sign&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Michel, Patrik; Ntaios, George [Centre Hospitalier Universitaire Vaudois and University of Lausanne, Neurology Service, Lausanne (Switzerland); Delgado, Montserrat G. [Hospital Universitario Central de Asturias, Oviedo (Spain); Bezerra, Daniel C. [Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, Baltimore, MD (United States); Meuli, Reto; Binaghi, Stefano [Centre Hospitalier Universitaire Vaudois and University of Lausanne, Department of Radiology, Lausanne (Switzerland)

    2012-02-15

    Currently, there is no reliable method to differentiate acute from chronic carotid occlusion. We propose a novel CTA-based method to differentiate acute from chronic carotid occlusions that could potentially aid clinical management of patients. We examined 72 patients with 89 spontaneously occluded extracranial internal carotids with CT angiography (CTA). All occlusions were confirmed by another imaging modality and classified as acute (imaging <1 week of presumed occlusion) orchronic (imaging >4 weeks), based on circumstantial clinical and radiological evidence. A neuroradiologist and a neurologist blinded to clinical information determined the site of occlusion on axial sections of CTA. They also looked for (a) hypodensity in the carotid artery (thrombus), (b) contrast within the carotid wall (vasa vasorum), (c) the site of the occluded carotid, and (d) the &apos;&apos;carotid ring sign&apos;&apos; (defined as presence of a and/or b). Of 89 occluded carotids, 24 were excluded because of insufficient circumstantial evidence to determine timing of occlusion, 4 because of insufficient image quality, and 3 because of subacute timing of occlusion. Among the remaining 45 acute and 13 chronic occlusions, inter-rater agreement (kappa) for the site of proximal occlusion was 0.88, 0.45 for distal occlusion, 0.78 for luminal hypodensity, 0.82 for wall contrast, and 0.90 for carotid ring sign. The carotid ring sign had 88.9% sensitivity, 69.2% specificity, and 84.5% accuracy to diagnose acute occlusion. The carotid ring sign helps to differentiate acute from chronic carotid occlusion. If further confirmed, this information may be helpful in studying ischemic symptoms and selecting treatment strategies in patients with carotid occlusions. (orig.)

  15. Depositional &apos;'cyclicity'&apos; on carbonate platforms: Real-world limits on computer-model output

    Energy Technology Data Exchange (ETDEWEB)

    Boss, S.K.; Neumann, A.C. (Univ. of North Carolina, Chapel Hill, NC (United States)); Rasmussen, K.A. (Northern Virginia Community Coll., Annandale, VA (United States))

    1994-03-01

    Computer-models which attempt to define interactions among dynamic parameters believed to influence the development of &apos;'cyclic'&apos; carbonate platform sequences have been popularized over the past few years. These models typically utilize vectors for subsidence (constant) and cyclical (sinusoidal) eustatic sea-level to create accommodation space which is filled by sedimentation (depth-dependent rates) following an appropriate lag time (non-depositional episode during initial platform flooding). Since these models are intended to reflect general principles of cyclic carbonate deposition, it is instructive to test their predictive utility by comparing typical model outputs with an actively evolving depositional cycle on a modern carbonate platform where rates of subsidence, eustatic sea-level and sediment accumulation are known. Holocene carbonate deposits across northern Great Bahama Bank provide such an ideal test-platform for model-data comparisons. On Great Bahama Bank, formation of accommodation space depends on eustatic sea-level rise because tectonic subsidence is very slow. Contrary to typical model input parameters, however, the rate of formation of accommodation space varies irregularly across the bank-top because irregular bank-top topography (produced by subaerial erosion and karstification) results in differential flooding of the platform surface. Results of this comparison indicate that typical computer-model input variables (subsidence, sea-level, sedimentation, lag-time) and output depositional geometries are poorly correlated with real depositional patterns across Great Bahama Bank. Since other modern carbonate platforms and ancient carbonate sequences display similarly complex stratigraphies, it is suggested that present computer-modeling results have little predictive value for stratigraphic interpretation.

  16. Parents’ Attitudes towards Adolescent Boy&apos;s Reproductive Health Needs and Practice in Tehran

    Directory of Open Access Journals (Sweden)

    Farideh K Abadi Farahani

    2007-05-01

    Full Text Available Objective: Parents are believed to be among the most influential adults who have a deterministic role in the success of interventional programs on adolescents&apos; reproductive health. The aim of this study is to describe parents&apos; perceptions and attitudes towards adolescent reproductive needs, experiences and associated factors. Method: A population-based study of 539 parents of adolescent boys, aged 15-18 in Tehran was conducted using a self-administered questionnaire. bivariate and multivariate analyses were performed to identify the factors associated with parents&apos; attitudes and their reports of adolescent heterosexual relationships. Results: Higher education, higher income, access to satellite programs and internet were associated with a liberal attitude among parents. Some demographic factors including adolescents&apos; age, lack of adolescents&apos; endorsement to religion, access to satellite programs, parents&apos; drinking, and various family factors such as poor parent-adolescent relationship, conflict, parental low valuation on education, parents&apos; low endorsement to morals, difficult parent-adolescent communication on important issues and finally easy communication about sex, were all among the factors associated with more frequent reports of having a girlfriend over the last year for the adolescent males. Parents&apos; reports on their adolescents&apos; sexual relationships with the opposite sex highlighted a significant gap with the figure reported for the adolescents aged 15-18 in a preceding study in 2002(3% vs. 28%. Conclusion: Parents should be advised to build a good relationship with teens, to maintain a close parent-teen communication, and to discuss morals and values with teens .

  17. Better spent. Towards an &apos;Evidence-based&apos; environmental policy; Beter besteed. Naar &apos;Evidence-based&apos; milieubeleid

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-11-01

    The aim of the &apos;Groene Rekenkamer&apos; (Green Audit Office) is to examine and review the scientific value of white papers, bills and other proposals on different environmental subjects. Also attention will be paid to the suitability, effectiveness and efficiency of laws and regulations with respect to public health and environmental targets and to analyze and clarify possible risks of the implementation of policy (cost benefit analysis) [Dutch] Milieu- en volksgezondheidsregels en -wetten blijken te vaak een zeer beperkte wetenschappelijke basis te hebben. Maatregelen op deze terreinen worden veelal ingegeven door publieke en politieke perceptie in plaats van harde wetenschappelijke gegevens. Met name op het gebied van milieu, ruimtelijke ordening en volksgezondheid heeft dit geleid tot dure, onnodige en soms zelfs contraproductieve maatregelen. De Groene Rekenkamer heeft als doel beleid- en wetsvoorstellen op verschillende terreinen te toetsen aan beschikbare wetenschappelijke gegevens. Daarnaast zal het haar taak zijn de doelmatigheid van wet en regelgeving (in termen van gestelde volksgezondheid en milieudoelen) te analyseren en de mogelijke risico&apos;s van beleidsimplementatie te verhelderen (kosten-baten analyse)

  18. Male infertility microsurgical training

    Institute of Scientific and Technical Information of China (English)

    Akanksha Mehta; Philip S Li

    2013-01-01

    Microsurgical training is imperative for urologists and clinical andrologists specializing in male infertility.Success in male infertility microsurgery is heavily dependent on the surgeon's microsurgical skills.Laboratory-based practice to enhance microsurgical skills improves the surgeon's confidence,and reduces stress and operating time,benefiting both the patient and the surgeon.This review provides guidelines for setting up a microsurgical laboratory to develop and enhance microsurgical skills using synthetic and animal models.The role of emerging techniques,such as robotic-assisted microsurgery,is also discussed.

  19. Analysis of &apos;&apos;new physics&apos;&apos; in the flavor sector using effective field theory methods

    Energy Technology Data Exchange (ETDEWEB)

    Dassinger, Benjamin M.

    2010-02-05

    The enormous amount of data collected by the B factories as well as the perspective concerning the upcoming experiments at the LHC provide us with the opportunity to perform high precision tests of the standard model. This dissertation presents two model independent precision tests of the weak sector of the standard model using extensions of the weak currents which are set up using effective field theory methods in order to control the size of the different contributions. Constraints on the coefficients of the terms can then be obtained by comparison with experimental results. The first analysis incorporates a test of the lefthandedness of the weak interaction in the quark sector. By introducing additional weak couplings the differential and total decay rates of the inclusive semileptonic decay anti B {yields} X{sub c}l anti {nu}{sub l} are calculated. The calculation includes the computation of the heavy-quark expansion which describes the interaction of the decaying b quark with respect to the background field of the B meson, up to order 1/m{sub b}{sup 4}. This has been done in a new, systematic way which does not involve the calculation of gluon matrix elements. Furthermore, radiative corrections have been included up to order O({alpha}{sub s}) including renormalization group running. The second part deals with the introduction of lepton flavor violating operators in the context of leptonic {tau} decays. These operators give rise to the effective four-fermion vertex {tau}{yields}ll{sup &apos;}l'&apos; as well as the subsequent radiative decay {tau}{yields}l{gamma}{sup *}{yields}ll{sup &apos;+}l{sup &apos;-}. The resulting Dalitz distributions turn out to predict completely different signatures for the radiative and the effective four-fermion vertices and provide the opportunity to check, whether the decay is induced either by a radiative or by an effective four-fermion vertex. Since different models which contain lepton flavor violation are normally more

  20. Traumatic case of Weber&apos;s syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Shirakuni, Takayuki; Tamaki, Norihiko; Matsumoto, Satoshi; Ishida, Kazuhiko; Fujiwara, Masayasu

    1983-06-01

    The present authors encountered a rare traumatic case of Weber&apos;s syndrome in which computerized tomography (CT) revealed a hematoma localized in the tegmentum of the midbrain. This 49-year-old male was admitted because of a disturbed consciousness level caused by a hit on the right frontal area in a traffic accident. A neurological examination on admission disclosed Weber&apos;s syndrome: a dilatation of the right pupil, no reaction to direct or indirect light stimuli, ptosis of the right eyelid, lateral deviation of the right eyeball, and left hemiparesis with increased deep tendon reflexes and Babinski&apos;s sign. CT revealed a high-density area localized in the tegmentum of the midbrain, but interpeduncular and quadrigeminal cisterns were patent. After admission, his motor function and level of consciousness have showed improvement with medical treatment, but his right oculomotor palsy is unchanged. CT performed 7 days after admission showed a low-density area in place of the absorbed hematoma. In this case, the mechanism of the primary brain-stem injury could not be explained. However, there are four possible mechanisms: nerve avulsion, neurovascular friction, localized contusion, and shear strain injury. Careful consideration of the anatomical relationship shows that it is likely that the lesion was a contusional hemorrhage caused by impact on the tentorial edge.

  1. Mothers&apos; Beliefs about Children&apos;s Learning in Hong Kong and the United States: Implications for Mothers&apos; Child-Based Worth

    Science.gov (United States)

    Ng, Florrie Fei-Yin; Pomerantz, Eva M.; Lam, Shui-fong

    2013-01-01

    Chinese and American mothers&apos; beliefs about children&apos;s learning and parents&apos; role in it were examined using notions salient in Chinese culture. Mothers from Hong Kong ("n" = 66) and the United States ("n" = 69) indicated their endorsement of the ideas that children&apos;s learning reflects children&apos;s…

  2. Zlouporaba droge i fizičko nasilje kod srednjoškolskih učenika: Neke karakteristike značajne za razvojni model prevencije

    OpenAIRE

    Radovanović, Ivana

    2013-01-01

    U mnoštvu rizičnih ponašanja kojima je izložena srednjoškolska mladež, zlouporaba droge i fizičko nasilje, bez sumnje, zauzimaju značajno mjesto. Znanstvena istraživanja rizičnih i protektivnih čimbenika i preventivni programi zasnovani na tim istraživanjima, značajna su pretpostavka učinkovitog sustava društvenog reagiranja na ova ponašanja. Istraživanje na uzorku od 488 učenika, obavljeno je u četiri srednje škole u Beogradu. Uzorak učenika ispitan je posebno izrađenog Upitnikom o ponaša...

  3. Recension de The Birth Of Chinese Feminism. Essential Texts in Transnational Theory. by L. H. Liu, R. E. Karl & D. Ko

    OpenAIRE

    Abbou, Julie

    2015-01-01

    Comment s'en sortir, 1; Recension de l'ouvrage The Birth Of Chinese Feminism. Essential Texts in Transnational Theory, édité par L. H. Liu, R. E. Karl & D. Ko.Cet ouvrage offre la première traduction en anglais des textes de la féministe anarchiste chinoise He-Yin Zhen, qui, au début du 20° siècle, voit dans la catégorisation de genre le modèle de toute catégorisation : un dispositif de pouvoir qui répartit la société selon un principe de domination, un mécanisme de division conceptuelle. Les...

  4. Anthropogenic impacts on the stability of the forest ecosystems in Belgrade - comparative analysis of Košutnjak forest and Zvezdarska forest

    Directory of Open Access Journals (Sweden)

    Rašković Dragana

    2015-01-01

    Full Text Available In this paper will be analyzed the environmental statusof the two recently protected forest areas in Belgrade -Košutnjak forest and Zvezdarska forest. Due to their specific position inside the urban structure, these park forests are exposed to the high level of pollution and degradation originating from anthropogenic sources. This paper will include all present forms of threats to the stability of these ecosystems, both in their immediate surroundings, as well as within their borders. For clear presentation of the devastating anthropogenic impact,on the protected forest ecosystems remote sensing - NDVI analysis of the appropriate satelite imagesegments will be preformed in order to detect the differences of the state of vegetation covers registrated in 1986 and 2010. According tothe need for efficient management system for the affected natural areas in the urban structure, in the end will be presented concrete protection measures, whose continous aplication can bring to the progradation of their state.

  5. Effect of primary degradation-reaction products from Ammonia Fiber Expansion (AFEX)-treated corn stover on the growth and fermentation of Escherichia coli KO11.

    Science.gov (United States)

    Lau, Ming W; Dale, Bruce E

    2010-10-01

    The primary degradation-reaction products (DRP) identified in Ammonia Fiber Expansion (AFEX)-pretreated corn stover are acetate, lactate, 4-hydroxybenzaldehyde (4HBD) and acetamide. The effects of these products at a broad concentration range were tested on Escherichia coli KO11, a strain engineered for cellulosic ethanol production. Fermentations using glucose or xylose as the sole carbohydrate source and a sugar mixture of glucose and xylose were conducted to determine how these products and sugar selection affected fermentation performance. Co-fermentation of the sugar mixture exhibited the lowest overall ethanol productivity compared to single-sugar fermentations and was more susceptible to inhibition. Metabolic ethanol yield increased with the increasing initial concentration of acetate. Although these degradation-reaction products (with exception of acetamide) are generally perceived to be inhibitory, organic acids and 4-hydroxybenzaldehyde at low levels stimulated fermentation. Adaptation of cells to these products prior to fermentation increased overall fermentation rate.

  6. IPSN activity report 1999; Rapport d&apos;activite de l&apos;IPSN 1999

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    The &apos;&apos;Institut de Protection et de Surete Nucleaire&apos;&apos; (IPSN), carries out researches and expert studies needed to manage nuclear risks and their consequences on people and environment. These activities cover the installation safety, the radioactive matter transport, the public health and environmental control, the nuclear matters safety and control and the crisis situation management. The IPSN have got also a mission of public information and participates to international actions in the domain of scientific researches or expert&apos;s report. This annual report presents the highlights of the year 1999, information on staff, budgets and geographical situation. Then technical and scientific papers gathers the activities of the year covered by the IPSN: the &apos;&apos;Free Tribune&apos;&apos;, installations and radioactive wastes safety, crisis and nuclear matter management, public health and environment control, international cooperation. (A.L.B.)

  7. ANDRA&apos;s news; L&apos;actualite de l&apos;Andra

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This press kit presents the three missions of the French national agency of radioactive wastes (ANDRA) and the main highlights of these three missions for the second half of 2003: 1 - industrial mission: the very low radioactive waste disposal facility of Morvilliers (543 m{sup 3} of waste packages already stored), the Aube disposal facility (exploitation data), the Manche disposal facility (adaptation to new monitoring standards); 2 - the research mission: the Meuse/Haute-Marne laboratory (progress of works and experimental program), the mobilization of competences (international expertise of ANDRA&apos;s researches about deep underground disposal, the coordination of the European program ESDRED); 3 - the information mission: national inventory of radioactive wastes, publications and events, recall of ANDRA&apos;s missions. (J.S.)

  8. Formation of helium induced nanostructure &apos;fuzz&apos; on various tungsten grades

    Energy Technology Data Exchange (ETDEWEB)

    Baldwin, M.J., E-mail: mbaldwin@ferp.ucsd.ed [Center for Energy Research and Department of Mechanical and Aerospace Engineering, University of California-San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0417 (United States); Doerner, R.P. [Center for Energy Research and Department of Mechanical and Aerospace Engineering, University of California-San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0417 (United States)

    2010-09-30

    The response of a variety of W material grades to nanostructure &apos;fuzz&apos; formation is explored. W targets are exposed to He or D{sub 2}-0.2He plasmas in PISCES-B at 900-1320 K to below sputter threshold He{sup +} ions of energy 25-60 eV for up to 2.2 x 10{sup 4} s. SEM and XPS reveal nanoscopic reorganization of the W surface to a layer of &apos;fuzz&apos; of porosity {approx}90% as determined by a &apos;fuzz&apos; removal/weight loss method. The variability of &apos;fuzz&apos; growth is examined at 1120 K for 1 h durations: SR, SC and doped W grades - La{sub 2}O{sub 3} (1% wt.), Re (5% and 10% wt.), and TiC (1.5% wt.) developed 2-3 {mu}m thick &apos;fuzz&apos; layers, while a VPS grade developed a layer 4 {mu}m thick. An RC grade revealed additional &apos;fuzz&apos; at deep (>100 {mu}m) grain boundaries. However, heat treatment up to 1900 K produced reintegration of &apos;fuzz&apos; with the bulk and He release at {approx}1000 K and {approx}1400-1800 K due to depopulation from vacancy complexes.

  9. Scenarios for an integrated sustainability policy - using the example of the &apos;&apos;Sustainable City 2030&apos;&apos;. Vol. 2; Szenarien fuer eine integrierte Nachhaltigkeitspolitik - am Beispiel: Die nachhaltige Stadt 2030. Bd. 2. Teilbericht &apos;&apos;Kreislaufstadt 2030&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Verbuecheln, Maic; Grabow, Busso; Uttke, Angela; Schwausch, Mandy [Deutsches Inst. fuer Urbanistik (DiFu), Berlin (Germany); Gassner, Robert [Institut fuer Zukunftsstudien und Technologiebewertung gGmbH (IZT), Berlin (Germany)

    2013-04-15

    The partial report &apos;&apos;Recycling City 2030&apos;&apos; was prepared for the Federal Environment Agency (Dessau, Federal Republic of Germany) as a part of the project &apos;&apos;Scenarios for an integrated sustainability policy - the example of &apos;The Sustainable City 2030 &apos;'&apos;. This partial report is based on research activities of the German Institute of Urban Affairs (Berlin, Federal Republic of Germany) and Institute for Futures Studies and Technology Assessment (Berlin, Federal Republic of Germany). The objectives of this partial report are: (1) Description of the challenges and trends in urban regions; (2) Recycling city and its importance in the current debate on sustainability; (3) Identification and optimization of existing cycle approaches in urban habitats; (4) Analysis of the actual state as well as designation of developments and constraints; (5) Discussion on the interface between the sectors; (6) Options for action for the interaction between the actors in interdisciplinary topics; (7) Outline of ways and perspectives of the implementation of the &apos;&apos;Recycling City 2030&apos;&apos;.

  10. Selection of foraging habitat and diet of the Hoopoe Upupa epops in the mosaic-like cultural landscape of Goričko (NE Slovenia

    Directory of Open Access Journals (Sweden)

    Podletnik Mojca

    2015-12-01

    Full Text Available In 2012 and 2013, the selection of foraging habitats and the diet of the Hoopoe Upupa epops were studied in the Goričko area, where a significant population decline of the species has been recorded in the past 15 years. Goričko is an area with a well-preserved traditional mosaic-like agricultural landscape very rich in biodiversity which, however, is disappearing. The diet was determined using automatic camera recordings of prey brought to chicks by parents. Mole crickets Gryllotalpa gryllotalpa were the most dominant prey (35.4% frequency and 81.3% biomass of prey, followed by Scarab beetles larvae Scarabaeidae, caterpillars Lepidoptera larvae and True flies Diptera. Feeding frequency was highest in the period of most intensive chick growth (between 8 and 21 days of age. Selection of foraging habitat was researched by observation of birds during foraging. Hoopoes foraged mostly in mown meadows and grassy courtyards and, to a lesser extent, on sandy cart tracks and road edges. These habitats were characterized by low vegetation and patches of bare ground that enabled Hoopoes to forage efficiently. Home range size was determined using minimum convex polygons. The maximum home range size was between 42.9 and 57.7 ha, while the percentage of foraging habitats within the home range did not exceed 18%. Based on our results, we propose the following measures for effective Hoopoe conservation in the area: maintaining the present range of existing unimproved meadows, stopping the conversion of meadows into fields, restoring fields to meadows, prohibiting the use of pesticides targeting Mole crickets.

  11. Preface: Proceedings of the 11th International Conference on Magnetic Fluids (ICMF 11) (Košice, Slovakia, 23 27 July 2007)

    Science.gov (United States)

    Kopčanský, Peter; Timko, Milan; Kováč, Josef; Václavíková, Miroslava; Odenbach, Stefan

    2008-05-01

    The 11th International Conference on Magnetic Fluids (ICMF 11) was held in Košice, Slovakia between 23-27 July 2007. Attendance at the conference was high and its motivation was in line with the ten previous ICMF conferences organized in Udine, Orlando, Bangor, Sendai-Tokyo, Riga, Paris, Bhavnagar, Timisoara, Bremen and Guarujá. The conference in Slovakia reflected the scientific community's enthusiasm and worldwide support, with 256 participants, from 30 countries attending.The main objective of ICMF 11 was to promote progress and knowledge in the field of magnetic fluids regarding their chemistry, physical and magnetic properties, heat and mass transfer, surface phenomena, as well as their technological and biomedical applications. As research on magnetic fluids is essentially interdisciplinary, experts from related areas were invited to present their contributions with a view to increasing knowledge in the field and highlighting new trends. Submitted communications were refereed by members of the Scientific Organizing Committee and abstracts were assembled in a book of abstracts. Participants presented 180 posters in two poster sessions and 56 oral presentations. All presentations contributed to a greater understanding of the area, and helped to bridge the gap between physics, chemistry, technology, biology and medical sciences. Contributions to this conference are presented in 115 scientific papers, with some published in Journal of Physics: Condensed Matter and the rest in Magnetohydrodynamics. The organization of the conference was made possible by generous support from the Institute of Experimental Physics and Institute of Geotechnics of the Slovak Academy of Sciences, the University of Pavol Jozef Šafárik and the Slovak Physical Society. Financial support from Ferrotec, Cryosoft Ltd, Mikrochem, Liquids Research Ltd, Askony and US Steel Košice, is also gratefully acknowledged.

  12. Comparing the fermentation performance of Escherichia coli KO11, Saccharomyces cerevisiae 424A(LNH-ST and Zymomonas mobilis AX101 for cellulosic ethanol production

    Directory of Open Access Journals (Sweden)

    Dale Bruce E

    2010-05-01

    Full Text Available Abstract Background Fermentations using Escherichia coli KO11, Saccharomyces cerevisiae 424A(LNH-ST, and Zymomonas mobilis AX101 are compared side-by-side on corn steep liquor (CSL media and the water extract and enzymatic hydrolysate from ammonia fiber expansion (AFEX-pretreated corn stover. Results The three ethanologens are able produce ethanol from a CSL-supplemented co-fermentation at a metabolic yield, final concentration and rate greater than 0.42 g/g consumed sugars, 40 g/L and 0.7 g/L/h (0-48 h, respectively. Xylose-only fermentation of the tested ethanologenic bacteria are five to eight times faster than 424A(LNH-ST in the CSL fermentation. All tested strains grow and co-ferment sugars at 15% w/v solids loading equivalent of ammonia fiber explosion (AFEX-pretreated corn stover water extract. However, both KO11 and 424A(LNH-ST exhibit higher growth robustness than AX101. In 18% w/w solids loading lignocellulosic hydrolysate from AFEX pretreatment, complete glucose fermentations can be achieved at a rate greater than 0.77 g/L/h. In contrast to results from fermentation in CSL, S. cerevisiae 424A(LNH-ST consumed xylose at the greatest extent and rate in the hydrolysate compared to the bacteria tested. Conclusions Our results confirm that glucose fermentations among the tested strains are effective even at high solids loading (18% by weight. However, xylose consumption in the lignocellulosic hydrolysate is the major bottleneck affecting overall yield, titer or rate of the process. In comparison, Saccharomyces cerevisiae 424A(LNH-ST is the most relevant strains for industrial production for its ability to ferment both glucose and xylose from undetoxified and unsupplemented hydrolysate from AFEX-pretreated corn stover at high yield.

  13. Compressed &apos;energy logs&apos;; Energiatukit tulevat

    Energy Technology Data Exchange (ETDEWEB)

    Fredriksson, T.

    1999-07-01

    In Sweden the utilization of forest fuels exceeds 5 million m{sup 3}/a. Two different solutions have been developed for compacting of the logging residues of final fellings. The operating principles of these methods differ from each other. Both these methods compress logging residues to &apos;energy logs&apos;, which can be processed and transported by ordinary forest machines and lorries, used for harvesting of timber. Fiberpack Ab has developed a machine which can compress logging residues or trees without any larger restrictions for raw material. Long tops and trees under 30 cm diameter can be compressed into cylindrical pieces, the diameter of which are 0.7 m, while the length can be defined freely. However, in practical operation the length is usually 3.2 m which enables in long-distance transportation the full load of a timber-lorry. In principle the Fiberpack can produce as long energy log as the amount of logging residues enable. Transportation defines the length of the log. Fiberpac-unit weights six tons, and the width in operational condition is 5.8 m. The length of the unit is 2.4 m and the height 1.9 m. The operation of the equipment has been reliable. Compacting of the logging residues occurs in three stages. In pre-compassion the residues are compressed between two rollers, in the second stage it is compressed further in square-shaped frame, after which it undergoes final compression and binding. The average weight of the &apos;logs&apos; is 550 kg. A normal timber-trailer takes 65-70 logs. The production of Fiberpac is 15-20 logs per hour. Frozen and snowy raw material is the hardest raw material, but both fresh and dried logging residues can be used for production of logs. The price of one Fiberpac-unit is about 1.4 million SEK. Another alternative is the machine developed by Wood Pac Ab, which resembles a cigarette roller. A medium-sized forest machine is used as the basic machine. The minimum power demand is 120 kW, and the efficiency of the

  14. Reply to &apos;&apos;Comment on &apos;Paramagnetic and ferromagnetic resonance studies on dilute magnetic semiconductors based on GaN&apos; &apos;&apos; [Phys. Status Solidi A 205, 1872 (2008)

    Energy Technology Data Exchange (ETDEWEB)

    Kammermeier, T. [Institut fuer Energie und Umwelttechnik e.V. (IUTA), Luftreinhaltung and Nachhaltige Nanotechnologie Unit, Bliersheimer Strasse 60, 47229 Duisburg (Germany); Fakultaet fuer Physik und CeNIDE, Universitaet Duisburg-Essen, 47057 Duisburg (Germany); Ney, A. [Fakultaet fuer Physik und CeNIDE, Universitaet Duisburg-Essen, 47057 Duisburg (Germany); Wieck, A.D. [Angewandte Festkoerperphysik, Ruhr-Universitaet Bochum, Universitaetsstr. 150, NB Building, 44780 Bochum (Germany)

    2011-08-15

    In a comment by Gehlhoff et al. on our work on &apos;&apos;Paramagnetic and ferromagnetic resonance studies on dilute magnetic semiconductors based on GaN&apos;&apos; [Phys. Status Solidi A 205, 1872 (2008)] the authors claim a contradictory explanation of angular dependent magnetic resonance measurements. Here we discuss their - solely based on computer simulations - claims. We show that an interpretation limited on magnetic impurities can hardly be used to explain the complex magnetic behavior. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  15. Know-how management &apos;&apos;Rock mechanics and support methods for the gate roads in the German coal mining industry&apos;&apos;; Wissensmanagement &apos;&apos;Gebirgsmechanik und Ausbautechnik fuer Floezstrecken im deutschen Steinkohlenbergbau

    Energy Technology Data Exchange (ETDEWEB)

    Junker, M. [Deutsche Steinkohle AG, Herne (Germany). Servicebereich Technik und Logistik; Schmidt, R.

    2006-03-23

    The R+D-project for establishment of a database with the entire know-how of the last 30 years from the &apos;&apos;Rock mechanics and support methods for gate roads in the German coal mining industry&apos;&apos; has so far been carried out as planned. After adaptation to the project the selected computer system was introduced. A planning module with recorded operational cases and a structured literature database is thus available to the Competence Centre for Road Supports in the Mining Technology Department of the Technology and Logistics Service Division of DSK. (Orig.)

  16. Assessment of the reproductive toxicity of inhalation exposure to ethyl tertiary butyl ether in male mice with normal, low active and inactive ALDH2.

    Science.gov (United States)

    Weng, Zuquan; Ohtani, Katsumi; Suda, Megumi; Yanagiba, Yukie; Kawamoto, Toshihiro; Nakajima, Tamie; Wang, Rui-Sheng

    2014-04-01

    No data are available regarding aldehyde dehydrogenase 2 (ALDH2) polymorphisms related to the reproductive toxicity possibly caused by ethyl tertiary butyl ether (ETBE). In this study, two inhalation experiments were performed in Aldh2 knockout (KO), heterogeneous (HT) and wild type (WT) C57BL/6 male mice exposed to ETBE, and the data about general toxicity, testicular histopathology, sperm head numbers, sperm motility and sperm DNA damage were collected. The results showed that the 13-week exposure to 0, 500, 1,750 and 5,000 ppm ETBE significantly decreased sperm motility and increased levels of sperm DNA strand breaks and 8-hydroxy-deoxyguanosine in both WT and KO mice, the effects were found in 1,750 and 5,000 ppm groups of WT mice, and all of the three exposed groups of KO mice compared to the corresponding control; furthermore, ETBE also caused decrease in the relative weights of testes and epididymides, the slight atrophy of seminiferous tubules of testis and reduction in sperm numbers of KO mice exposed to ≥500 ppm. In the experiment of exposure to lower concentrations of ETBE (0, 50, 200 and 500 ppm) for 9 weeks, the remarkable effects of ETBE on sperm head numbers, sperm motility and sperm DNA damage were further observed in KO and HT mice exposed to 200 ppm ETBE, but not in WT mice. Our findings suggested that only exposure to high concentrations of ETBE might result in reproductive toxicity in mice with normal active ALDH2, while low active and inactive ALDH2 enzyme significantly enhanced the ETBE-induced reproductive toxicity in mice, even exposed to low concentrations of ETBE, mainly due to the accumulation of acetaldehyde as a primary metabolite of ETBE.

  17. A tortoiseshell male cat

    DEFF Research Database (Denmark)

    Pedersen, A. S.; Berg, Lise Charlotte; Almstrup, Kristian

    2014-01-01

    . Immunostaining using anti-vimentin and anti-VASA (DDX4) showed that only Sertoli cells and no germ cells were observed in the testicular tubules. As no sign of spermatogenesis was detected, we conclude that this is a classic case of a sterile, male tortoiseshell cat with a 39,XXY chromosome complement. © 2013 S...

  18. Male rat sexual behavior.

    Science.gov (United States)

    Agmo, A

    1997-05-01

    The male rat's sexual behavior constitutes a highly ordered sequence of motor acts involving both striate and smooth muscles. It is spontaneously displayed by most adult made rats in the presence of a sexually receptive female. Although the behavior is important for the survival of the species it is not necessary for survival of the individual. In that way it is different from other spontaneous behaviors such as eating, drinking, avoidance of pain, respiration or thermoregulation. Among other things, this means that it is difficult to talk about sexual deprivation or need. Nevertheless, studies of male sex behavior distinguish sexual motivation (the ease by which behavior is activated, "libido") from the execution of copulatory acts (performance, "potency") (Meisel, R.L. and Sachs, B.D., The physiology of male sexual behavior. In: E. Knobil and J.D. Neill (Eds.), The Physiology of Reproduction, 2nd Edn., Vol. 2, Raven Press, New York, 1994, pp. 3-105 [13]). The hormonal control of male sexual behavior has been extensively studied. It is clear that steroid hormones, androgens and estrogens, act within the central nervous system, modifying neuronal excitability. The exact mechanism by which these hormones activate sex behavior remains largely unknown. However, there exists a considerable amount of knowledge concerning the brain structures important for sexual motivation and for the execution of sex behavior. The modulatory role of some non-steroid hormones is partly known, as well as the consequences of manipulations of several neurotransmitter systems.

  19. Male Reproductive System

    Science.gov (United States)

    ... designed to produce, nourish, and transport either the egg or sperm. Unlike the female, whose sex organs are located ... zygote and contains 46 chromosomes — half from the egg and half from the sperm. The genetic material from the male and female ...

  20. Lycopene and male infertility

    Institute of Scientific and Technical Information of China (English)

    Damayanthi Durairajanayagam; Ashok Agarwal; Chloe Ong; Pallavi Prashast

    2014-01-01

    Excessive amounts of reactive oxygen species (ROS) cause a state of oxidative stress, which result in sperm membrane lipid peroxidation, DNA damage and apoptosis, leading to decreased sperm viability and motility. Elevated levels of ROS are a major cause of idiopathic male factor infertility, which is an increasingly common problem today. Lycopene, the most potent singlet oxygen quencher of all carotenoids, is a possible treatment option for male infertility because of its antioxidant properties. By reacting with and neutralizing free radicals, lycopene could reduce the incidence of oxidative stress and thus, lessen the damage that would otherwise be inlficted on spermatozoa. It is postulated that lycopene may have other beneifcial effects via nonoxidative mechanisms in the testis, such as gap junction communication, modulation of gene expression, regulation of the cell cycle and immunoenhancement. Various lycopene supplementation studies conducted on both humans and animals have shown promising results in alleviating male infertility-lipid peroxidation and DNA damage were decreased, while sperm count and viability, and general immunity were increased. Improvement of these parameters indicates a reduction in oxidative stress, and thus the spermatozoa is less vulnerable to oxidative damage, which increases the chances of a normal sperm fertilizing the egg. Human trials have reported improvement in sperm parameters and pregnancy rates with supplementation of 4-8 mg of lycopene daily for 3-12 months. However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene as a treatment for male infertility.

  1. Testosterone and the Male Skeleton: A Dual Mode of Action

    Directory of Open Access Journals (Sweden)

    Mieke Sinnesael

    2011-01-01

    Full Text Available Testosterone is an important hormone for both bone gain and maintenance in men. Hypogonadal men have accelerated bone turnover and increased fracture risk. In these men, administration of testosterone inhibits bone resorption and maintains bone mass. Testosterone, however, is converted into estradiol via aromatization in many tissues including male bone. The importance of estrogen receptor alpha activation as well of aromatization of androgens into estrogens was highlighted by a number of cases of men suffering from an inactivating mutation in the estrogen receptor alpha or in the aromatase enzyme. All these men typically had low bone mass, high bone turnover and open epiphyses. In line with these findings, cohort studies have confirmed that estradiol contributes to the maintenance of bone mass after reaching peak bone mass, with an association between estradiol and fractures in elderly men. Recent studies in knock-out mice have increased our understanding of the role of androgens and estrogens in different bone compartments. Estrogen receptor activation, but not androgen receptor activation, is involved in the regulation of male longitudinal appendicular skeletal growth in mice. Both the androgen and the estrogen receptor can independently mediate the cancellous bone-sparing effects of sex steroids in male mice. Selective KO studies of the androgen receptor in osteoblasts in male mice suggest that the osteoblast in the target cell for androgen receptor mediated maintenance of trabecular bone volume and coordination of bone matrix synthesis and mineralization. Taken together, both human and animal studies suggest that testosterone has a dual mode of action on different bone surfaces with involvement of both the androgen and estrogen receptor.

  2. OJT. make &apos;em or break &apos;em

    Energy Technology Data Exchange (ETDEWEB)

    Arner, S.A.

    1992-01-01

    On-the-job training (OJT) has been with us in varying forms for longer than perhaps any other type of training. In reality, OJT is a process for accomplishing change; change in an employee&apos;s ability to perform assigned job duties. However, bringing about that change can often be a difficult process. A clear understanding of what change really is and what it entails is essential to easing its process. this document discusses the methodology in OJT and emphasizes the importance of communications in this process.

  3. Aids to decision in selection of valve stem seals in accordance with the &apos;&apos;TA Luft&apos;&apos; requirements, 2002 edition; Entscheidungshilfen fuer die Auswahl von Spindelabdichtungen nach TA-Luft-Anforderungen - Ausgabe 2002

    Energy Technology Data Exchange (ETDEWEB)

    Wodara, G. [Phoenix Armaturen Werke Bregel GmbH, Volkmarsen (Germany)

    2005-12-01

    &apos;&apos;TA Luft&apos;&apos; (&apos;&apos;Technical Directive for Prevention of Air Pollution&apos;&apos;), 2002, specifies high-quality-sealing metal bellows with a downstream safety gland, or equivalent sealing systems, for the sealing of valva stems. According to &apos;&apos;TA Luft&apos;&apos;, sealing systems may be considered equivalent provided the temperature-specific rates of leakage are met in the VDI 2440 (November, 2000 edition) test and detection procedure. &apos;&apos;High-quality metal bellows with downstream safety gland&apos;&apos; and various &apos;&apos;spring-load gland packings&apos;&apos; are examined in this article on the criterion of the requirements of &apos;'TA-Luft'&apos;, on the bases of testing in accordance with TA Luft 2002 VDI 2440 and a test in accordance with DIN EN ISO 15 848, Part 1. The result: There is, for the bello with downstream safety gland, no alternative which fulfills all the requirements of &apos;&apos;TA Luft&apos;&apos;. The spring-loaded gland packing and, according to the relevant literature, the double gland packing with barrier fluid and exhausting, which is not examined here, do provide a potential alternative for lower load-cycle numbers. The fact that design specifications and the packing and valve manufacturers&apos; installation instructions were taken into account for valve stem surfaces, gap tolerances, packing-ring arrangement, and tightening torques for precompression and final compression, was decisive for fulfillment of the requirements of TA Luft, VDI 2440 in the tests examined in this article. (orig.)

  4. The Visionary&apos;s Dilemma

    Energy Technology Data Exchange (ETDEWEB)

    WALSH,STEVE; MYERS,DAVID R.; SUMPTER,CAROL W.; JAKUBCZAK II,JEROME F.

    2001-10-12

    Novel technologies often are born prior to identifying application arenas that can provide the financial support for their development and maturation. After creating new technologies, innovators rush to identify some previously difficult-to-meet product or process challenge. In this regard, microsystems technology is following a path that many other electronic technologies have previously faced. From this perspective, the development of a robust technology follows a three-stage approach. First there is the &apos;&apos;That idea will never work.&apos;&apos; stage, which is hurdled only by proving the concept. Next is the &apos;&apos;Why use such a novel (unproven) technology instead of a conventional one?&apos;&apos; stage. This stage is overcome when a particular important device cannot be made economically--or at all--through the existing technological base. This initial incorporation forces at least limited use of the new technology, which in turn provides the revenues and the user base to mature and sustain the technology. Finally there is the &apos;&apos;Sure that technology (e.g., microsystems) is good for that product (e.g., accelerometers and pressure sensors), but the problems are too severe for any other application&apos;&apos; stage which is only overcome with the across-the-board application of the new technology. With an established user base, champions for the technology become willing to apply the new technology as a potential solution to other problems. This results in the widespread diffusion of the previously shunned technology, making the formerly disruptive technology the new standard. Like many technologies in the microelectronics industry, the microsystems community is now traversing this well-worn path. This paper examines the evolution of microsystems technology from the perspective of Sandia National Laboratories&apos; development of a sacrificial surface micromachining technology and the associated infrastructure.

  5. Search for B Meson Decays to eta&apos; eta&apos; K

    Energy Technology Data Exchange (ETDEWEB)

    Aubert, B.

    2006-05-05

    The authors describe searches for decays of B mesons to the charmless final states {eta}&apos;{eta}&apos;K. The data consist of 228 million B{bar B} pairs produced in e{sup +}e{sup -} annihilation, collected with the BABAR detector at the Stanford Linear Accelerator Center. The 90% confidence level upper limits for the branching fractions are {Beta}(B{sup 0} {yields} {eta}&apos;{eta}&apos;K{sup 0}) < 31 x 10{sup -6} and {Beta}(B{sup +} {yields} {eta}&apos;{eta}&apos;K{sup +}) < 25 x 10{sup -6}.

  6. U-Pb zircon geochronology of &apos;'brasiliano'&apos; granitoids from the Serido orogenic belt (Borborema Province, NE Brazil). Ages U-Pb sur zircon de granitoides &apos;'brasilianos'&apos; de la ceinture du Serido (Province Borborema, NE Bresil)

    Energy Technology Data Exchange (ETDEWEB)

    Leterrier, J.; Bertrand, J.M. (Centre National de la Recherche Scientifique (CNRS), 54 - Nancy (France). Centre de Recherches Petrographiques et Geochimiques); Pin, C. (Clermont-Ferrand-2 Univ., 63 - Aubiere (France)); Jardim de Sa, E.

    1994-06-01

    Diorites previously attributed to an early stage of the &apos;brasiliano&apos; plutonic evolution of the Serido belt yielded U-Pb zircon age of 579 [+-]7 Ma. The age of associated granites is slightly younger although a synchronous emplacement of granites and diorites is suggested by field relationships. Such an age difference may result from difficulties to distinguish &apos;crystallization age&apos; from &apos;emplacement age&apos;, which is still to be determined precisely. (authors). 16 refs., 3 figs., 1 tab.

  7. PubliForum &apos;Electricity and Society&apos;. Citizen Panel Report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-06-01

    In the Citizen Panel&apos;s Report on &apos;Electricity and Society&apos; we present the first results of three intensive week-ends. In this document, 27 Swiss citizens have recorded their opinions on the future of our electricity supply system. Solutions are sought without making claims on having found the ultimate recipe. The recommendations are the result of an assessment made by a representative cross-section of the public - one could almost say &apos;the voice of the people&apos;. They reflect not only the public&apos;s apprehensions and worries, but also their ideas and desires. (authors)

  8. Measuring Beliefs in Centimeters: Private Knowledge Biases Preschoolers&apos; and Adults&apos; Representation of Others&apos; Beliefs

    Science.gov (United States)

    Sommerville, Jessica A.; Bernstein, Daniel M.; Meltzoff, Andrew N.

    2013-01-01

    A novel task, using a continuous spatial layout, was created to investigate the degree to which (in centimeters) 3-year-old children&apos;s ("N" = 63), 5-year-old children&apos;s ("N" = 60), and adults&apos; ("N" = 60) own privileged knowledge of the location of an object biased their representation of a…

  9. Acute effects of interleukin-6 infusion on apo-B-containing lipoprotein subclasses in humans

    DEFF Research Database (Denmark)

    Bagdade, John; Pedersen, Bente K; Schwenke, Dawn;

    2011-01-01

    B:E) apoB-containing subclasses present in VLDL. Therefore, we have directly measured these subclasses following their isolation by sequential immunoprecipitation in seven healthy male subjects during a 3-h infusion with recombinant human (rh) IL-6. Though plasma TG and apoB-containing particle number were...... unchanged by IL-6, the distribution of TG-rich subclasses was significantly altered. Compared to baseline values, LpB:E + LpB:C:E increased significantly at 0.5 h (p infused controls at 0.5 and 1 h (p

  10. Dat&apos;a&apos; RTE - &apos; Balance Responsible data &apos; Service. You would like to manage your activities more effectively, and that&apos;s why RTE is offering new services that give you access to personalized data; Dat&apos;a&apos; RTE offre &apos;&apos;donnees de responsable d&apos;equilibre'&apos;. Vous souhaitez mieux piloter vos activites, RTE vous propose un nouveau service de mise a disposition de donnees personnalisees

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-06-01

    RTE, the French manager of the power transportation network, already offers a service under which it publishes public data on its web site ; it aims to improve the way the electricity market works in a transparent and nondiscriminatory fashion. To better respond to the needs of actors in the electricity market, RTE has developed new Dat&apos;a&apos; RTE services, giving them access to detailed, personalized and confidential data. Dat&apos;a&apos; RTE is the main electronic channel used for exchanging personalized data between RTE and customers. The &apos;Balance Responsible Data&apos; service completes and enhances the other services associated with the &apos;Balance Responsible Entity&apos; service. For a detailed picture and greater reactivity, the customers have access to the basic data used to calculate imbalances as soon as they are processed by RTE. They become definitive from the point in time specified in the Balance Responsible Entity contractual documents. The price of this service is dependent upon the size of the customer&apos;s Balance Responsible perimeter.

  11. 3&apos;,8&apos;&apos;-biisokaempferide, a cytotoxic biflavonoid and other chemical constituents of Nanuza plicata (Velloziaceae)

    Energy Technology Data Exchange (ETDEWEB)

    Pinto, Meri Emili F.; Silva, Marcelo Sobral da; Barbosa Filho, Jose Maria; Castello-Branco, Marianna Vieira S.; Agra, Maria de Fatima; Tavares, Josean Fechine, E-mail: marcelosobral@ltf.ufpb.b [Universidade Federal da Paraiba (UFPB), Joao Pessoa, PB (Brazil). Lab. de Tecnologia Farmaceutica; Schindler, Elisabete; El-Bacha, Ramon dos Santos [Universidade Federal da Bahia (UFBA), Salvador, BA (Brazil). Inst. de Ciencias da Saude. Lab. de Neuroquimica e Biologia Celular

    2010-07-01

    A novel biflavonoid, named 3&apos;,8&apos;&apos;-biisokaempferide (1), along with the known compounds amentoflavone (2), patagonic acid (3), (4aR,5S,6R,8aR)-5-[2-(2,5-Dihydro-5-methoxy-2-oxofuran- 3-yl)ethyl]-3,4,4a,5,6,7,8,8a-octahydro-5,6,8a- trimethylnaphthalene-1-carboxylic acid (4), 5-caffeoylquinic acid methyl ester (5), 3,5-di-caffeoylquinic acid (6) and luteolin (7), were isolated of the leaves from Nanuza plicata. The compounds 3, 4, 5 and 6 are reported for the first time in Velloziaceae. The structures of the compounds were elucidated on the basis of spectroscopic methods, especially NMR and MS analyses. The cytotoxicity of 3&apos;,8&apos;&apos;-biisokaempferide was studied in cultures of human glioblastoma GL-15 cells. The effective concentration, which killed 50 % of cells after 72 h was 36.5 {mu}mol L{sup -1}. Changes in cellular morphology, including retraction and degradation of cytoplasm, were observed when cells were treated with concentrations from 20 {mu}mol L-1 of 3&apos;,8&apos;&apos;-biisokaempferide for 72 h. (author)

  12. The role of bioenergy in the energy transition. The &apos;&apos;Smart Bioenergy&apos;&apos; concept; Die Rolle der Bioenergie in der Energiewende. Das &apos;&apos;Smart Bioenergy&apos;&apos;-Konzept

    Energy Technology Data Exchange (ETDEWEB)

    Thraen, Daniela [Helmholtz-Zentrum fuer Umweltforschung - UFZ, Leipzig (Germany). Dept. Bioenergie (BEN); DBFZ Deutsches Biomasseforschungszentrum gGmbH, Leipzig (Germany). Bereich Bioenergiesysteme; Seitz, Stefanie B.; Wirkner, Ronny; Nelles, Michael [DBFZ Deutsches Biomasseforschungszentrum gGmbH, Leipzig (Germany). Bereich Bioenergiesysteme

    2016-08-01

    The energy system&apos;s transformation away from fossil and therefore finite resources and ecological harmful use towards renewable energy sources and sustainable forms of usage proceeds. But even after 35 years, the German energy transition has yet not reached its ambitious goals. Moreover, in the recent years the progress has stagnated in certain areas. This is due to the fact that one of the central challenges of the energy system&apos;s changeover to an sole use renewable energy (RE) have not yet mastered: the reliable and stable delivery of RE for all energy dependent sectors starting form electricity via heat to mobility in the face of fluctuating energy sources like sun and wind. Bioenergy with its flexible use of innovative technologies and smart integration in the overall system is therefore vital to grant stability of energy supply. Furthermore, bioenergy can recourse on sustainable resources and may become therefore the backbone of the future bioeconomy. For this purpose an integrative approach is necessary that aligns the aforementioned building blocks in a cohesive whole: the Smart Bioenergy concept - that will be presented here with its elements but also open questions and challenges.

  13. ApoE plasma levels and risk of cardiovascular mortality in old age.

    Directory of Open Access Journals (Sweden)

    Simon P Mooijaart

    2006-06-01

    Full Text Available BACKGROUND: The epsilon2, epsilon3, and epsilon4 alleles of the apolipoprotein E gene (APOE encode three isoforms, apoE2, E3, and E4, respectively. The apoE isoforms circulate in different plasma concentrations, but plasma concentrations of the same isoform also differ between individuals. Whereas the isoforms have been associated with cardiovascular disease, the relation between plasma apoE levels and cardiovascular disease is unknown. METHODS AND FINDINGS: We assessed APOE genotypes, plasma levels of apoE, cardiovascular risk factors, and mortality in a population-based sample of 546 individuals aged 85 y who participated in the Leiden 85-plus Study and were prospectively followed for specific causes of death for 5 y. Participants in the highest tertile of apoE levels suffered a twofold-increased risk of cardiovascular mortality (hazard ratio compared to lowest tertile, 2.08; 95% confidence interval [CI], 1.30 to 3.33. Among the 324 participants with the epsilon3epsilon3 genotype, the hazard from cardiovascular disease was threefold increased (highest versus lowest tertile 3.01; 95% CI 1.60 to 5.66, with similar estimates for men and women. Other causes of death were not increased significantly. Plasma levels of apoE in epsilon3epsilon3 participants were positively correlated with total cholesterol (p < 0.001, low-density lipoprotein cholesterol (p < 0.001 and triglycerides (p < 0.001 and negatively with high-density lipoprotein cholesterol levels (p = 0.010. Adjustment for plasma lipids did not change the hazard ratios, whereas interaction was absent. The risk associated with high levels of apoE, however, was strongest in participants from the lowest tertile of C-reactive protein (CRP levels and absent in those from the highest tertile (p(interaction < 0.001. Among participants from the lowest tertile of CRP levels, those with a high apoE levels had a significantly steeper increase in CRP than those with low apoE levels (p = 0.020. Similar

  14. EPA&apos;s (Environmental Protection Agency&apos;s) draft drinking-water criteria document for monochlorobenzene. Technical comments of the Halogenated Organics Subcommittee. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1987-01-16

    The Halogenated Organics Subcommittee evaluated the animal evidence for carcinogencity of chlorobenzene to be inadequate under EPA&apos;s new guidelines based on the lack of a statistically significant increase in the incidence of tumors in female mice, male mice and female rats, and on the basis of the perception of a diminished biologic significance of reported malignant neoplastic nodules of the liver in the highest dose-treated male rats. The evidence would place chlorobenzene into the overall weight-of-the-evidence category D (not classified).

  15. Active pollution reduction in the &apos;off-road&apos; sector. Proceedings; Aktive Schadstoffminderung im &apos;Off-road&apos; Bereich. Tagungsband

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The state of the art and trends in off-gas purification and filters were gone into. The focus was on technical aspects, performance information and cost of diesel engines with high-efficiency exhaust purification systems as well as on sulfur-free fuels. [German] Mit der Tagung &apos;Aktive Schadstoffminderung im &apos;'Off-road'&apos; Bereich&apos; bieten wir eine besondere Gelegenheit zur Information und Auseinandersetzung mit dem derzeitigen Stand und den Entwicklungsperspektiven der Abgasreinigung und Filtertechnik bei Neubeschaffungen und in der Nachruestung. Gerade in staedtischen Ballungsgebieten, aber auch in geschlossenen Raeumen und Produktionshallen sind die Reduzierung der lokalen Emissionen und Vermeidung von Geruchsbelaestigungen unabdingbar. Im Mittelpunkt stehen Technik, Betriebserfahrungen und Kosten von Dieselmotoren mit hocheffizienter Abgasreinigung sowie schwefelfreie Kraftstoffe. (orig.)

  16. Holistic oil field value management: using system dynamics for &apos;intermediate level&apos; and &apos;value-based&apos; modelling in the oil industry

    Energy Technology Data Exchange (ETDEWEB)

    Corben, D.; Stevenson, R.; Wolstenholme, E.F. [Cognitus Ltd., Harrogate (United Kingdom)

    1999-07-01

    System dynamics has been seen primarily as a strategic tool, most effectively used at the highest level of strategy to identify robust policy interventions under a wide range of scenarios. However, an alternative, complementary and powerful role is emerging. This is at an &apos;intermediate level&apos; in organisations to coordinate and integrate policies across the value chain. It is at this level where business value, as defined by the discounted value of future free cash flow, is both created and destroyed. This paper introduces the need for &apos;intermediate-level&apos; and &apos;value-based&apos; modelling and emphasises the natural role of system dynamics in supporting a methodology to fulfil the need. It describes the development of an approach and its application in the oil industry to coordinate the response of people and tools within operational, financial and commercial functions across the value chain to address a variety of problems and issues. (author)

  17. Highly specific &apos;'sensing'&apos; of tryptophan by a luminescent europium(III) complex

    Energy Technology Data Exchange (ETDEWEB)

    Stubenrauch, Jan A.; Mevissen, Christian; Schulte, Marie F.; Bochenek, Steffen; Albrecht, Markus [RWTH Univ. Aachen (Germany). Inst. fuer Organische Chemie; Subramanian, Palani S. [Central Salt and Marine Chemicals, Research Institute (CSRI), Gujarat (India)

    2016-07-01

    The europium(III) complex 1-Cl{sub 3} (S,S-2,2{sup &apos;}-(((1,10-phenanthroline-2,9-diyl)bis(methanylylidene))bis (azanylyliden e))bis(3-methylbutanamide)europiumtrichloride) undergoes, only in the presence of the amino acid tryptophan, a change of emission at 615 nm. In the presence of few equivalents of tryptophan, emission of the europium complex is enhanced while it disappears upon addition of large amounts. This behavior can be assigned to displacement of the sensitizing phenanthroline ligand of 1-Cl{sub 2} x Trp in the latter case.

  18. ANALYZE Users&apos; Guide

    Energy Technology Data Exchange (ETDEWEB)

    Azevedo, S.

    1982-10-01

    This report is a reproduction of the visuals that were used in the ANALYZE Users&apos; Guide lectures of the videotaped LLNL Continuing Education Course CE2018-H, State Space Lectures. The course was given in Spring 1982 through the EE Department Education Office. Since ANALYZE is menu-driven, interactive, and has self-explanatory questions (sort of), these visuals and the two 50-minute videotapes are the only documentation which comes with the code. More information about the algorithms contained in ANALYZE can be obtained from the IEEE book on Programs for Digital Signal Processing.

  19. Theory perspective: SCES &apos;05 Vienna

    Energy Technology Data Exchange (ETDEWEB)

    Coleman, P. [Center for Materials Theory, Rutgers University, Piscataway, NJ 08855 (United States)]. E-mail: coleman@physics.rutgers.edu

    2006-05-01

    Over the past decades, there has been research on strongly correlated electron materials that has consistently outperformed our wildest expectations, with new discoveries and radically new theoretical insights. SCES &apos;05 reaffirmed this vitality. Highlight areas included parity violating superconductivity, a new, two-dimensional helium-3 &apos;Kondo lattice&apos; and the discovery of quantum critical ferro-electricity. I review these and many other developments, with an emphasis on open questions and prospects for the future.

  20. Myonecrosis of Behcet&apos;s disease

    Energy Technology Data Exchange (ETDEWEB)

    Stubbs, Alana Y. [Southern Arizona Veterans Administration Health Care System, Department of Radiology, Tucson, AZ (United States); Taljanovic, Mihra S. [University of Arizona HSC, Radiology and Orthopaedic Surgery, Department of Radiology, Tucson, AZ (United States); Massey, Brandon Z. [The Village Offices, Institute for Plastic Surgery and Peripheral Nerve Surgery, Tucson, AZ (United States); Graham, Anna R. [University of Arizona HSC, Department of Pathology, Tucson, AZ (United States); Friend, Christopher J.; Walsh, Joshua A. [Inland Imaging, LLC, Spokane, WA (United States)

    2008-04-15

    Behcet&apos;s disease is an inflammatory disease of unknown cause characterized by intermittent episodes of acute inflammation manifested by oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. We report a rare case of myonecrosis associated with Behcet&apos;s disease. Myonecrosis of Behcet&apos;s disease can mimic soft tissue abscess and therefore awareness of this entity in the appropriate clinical setting is important for initiation of appropriate and timely treatment. (orig.)

  1. Male Gender Role Dysfunction

    OpenAIRE

    Daig, Isolde

    2010-01-01

    Background: Men have a higher alcohol and cigarette consumption than women, they use more drugs, they have twice as high a suicide rate and only a minority of men attend on preventive medical checkups. Hypotheses: The central questions of the present study pertained to the identification of dysfunctional aspects of a male self concept and the possible correlations with risk behaviour of men in different age stages. One possible explanation for this high risk behaviour may be higher mascul...

  2. Einstein-Rosen &apos;bridge&apos; needs lightlike brane source

    Energy Technology Data Exchange (ETDEWEB)

    Guendelman, Eduardo, E-mail: guendel@bgu.ac.i [Department of Physics, Ben-Gurion University of the Negev, PO Box 653, IL-84105 Beer-Sheva (Israel); Kaganovich, Alexander, E-mail: alexk@bgu.ac.i [Department of Physics, Ben-Gurion University of the Negev, PO Box 653, IL-84105 Beer-Sheva (Israel); Nissimov, Emil, E-mail: nissimov@inrne.bas.b [Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences, Boul. Tsarigradsko Chausee 72, BG-1784 Sofia (Bulgaria); Pacheva, Svetlana, E-mail: svetlana@inrne.bas.b [Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences, Boul. Tsarigradsko Chausee 72, BG-1784 Sofia (Bulgaria)

    2009-11-16

    The Einstein-Rosen &apos;bridge&apos; wormhole solution proposed in the classic paper (Einstein and Rosen (1935) ) does not satisfy the vacuum Einstein equations at the wormhole throat. We show that the fully consistent formulation of the original Einstein-Rosen &apos;bridge&apos; requires solving Einstein equations of bulk D=4 gravity coupled to a lightlike brane with a well-defined world-volume action. The non-vanishing contribution of Einstein-Rosen &apos;bridge&apos; solution to the right-hand side of Einstein equations at the throat matches precisely the surface stress-energy tensor of the lightlike brane which automatically occupies the throat (&apos;horizon straddling&apos;) - a feature triggered by the world-volume lightlike brane dynamics.

  3. &apos;Minergie&apos; on a large scale; Minergie im Grossformat

    Energy Technology Data Exchange (ETDEWEB)

    Hawkins, A. C.

    2007-07-01

    This article takes a look at two housing estates in the suburbs of Zurich, Switzerland, that conform to &apos;Minergie&apos; low energy-consumption standards. In contrast to single-family homes normally associated with the &apos;Minergie&apos; low energy-consumption label, here, two &apos;Minergie&apos; housing estates each with a number of apartment blocks are looked at. The systems for providing regulated fresh air with heat recovery are described. In one of the estates, heat is collected from a nearby sewer via heat-exchangers and, together with a heat-pump system, is used to heat the apartments. Nearby, in the other &apos;Minergie&apos; estate, a large, mains-connected photovoltaics plant is used to meet the net power requirements of a heat-pump-based heating system. In summer, power is sold to the local electricity utility.

  4. VDE/ITG position paper energy information networks and systems. Pt. A. &apos;&apos;Distribution grid automation in the smart grid&apos;&apos;; VDE/ITG-Positionspapier Energieinformationsnetze und -systeme. T. A. &apos;&apos;Verteilungsnetzautomatisierung im Smart Grid&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Huebner, Christian [ifak e.V., Magdeburg (Germany)

    2012-07-01

    The present paper reports results of the VDE / ITG focus group &apos;&apos;Energy Information Networks and Systems&apos;&apos; that published its second position paper in autumn 2012. The focus was on the issue of distribution automation, since the successful implementation of a smart energy system can be achieved only on the basis of a profound automation of distribution networks and other systems of energy supply interacting with them. With the participation of experts from the fields of energy supply, telecommunications, IT and automation technology, various aspects of distribution automation in the context of smart grid were analyzed and appropriate recommendations derived. The results are summarized in Part A &apos;&apos;Distribution Automation in Smart Grid&apos;&apos; of the position paper. (orig.)

  5. Those who &apos;Cry Wolf&apos; about nuclear safety damage their own credibility

    Energy Technology Data Exchange (ETDEWEB)

    Shepherd, John [nuclear 24, Redditch (United Kingdom)

    2016-06-15

    Do you recall the fable of the boy who cried wolf? I was reminded of this following the latest call by Germany&apos;s Federal Environment Minister, Barbara Hendricks, for Belgium to take two of its nuclear reactors off the grid, citing &apos;'questions'&apos; about the units&apos; safety. Those in positions of power and influence in one country should take care to be as responsible in their dealings with their neighbours as they are in handling domestic matters of state. Those who see &apos;danger&apos; where there is none are not being good neighbours. They are generating fear and alarm without good cause and should mind their own business.

  6. Atoms of helium in interstellar and interplanetary medium. 1. Observations of scattering ultraviolet radiation in lines of HI lambda 1216 A and HeI lambda 584 A by the &apos;&apos;Prognoz-5&apos;&apos; and &apos;&apos;Prognoz-6&apos;&apos; satellites

    Energy Technology Data Exchange (ETDEWEB)

    Burgin, M.S.; Kurt, V.G.; Mironova, E.N.; Prokhorenko, V.I.; Ehjsmont, N.A.; Berto, Zh.L.; Dalod' e, F.

    A review of observation results of the joint Soviet- French experiment on the measurement of scattering ultraviolet radiation in interplanetary medium in HIlambda1216 A and HeI 584 A hydrogen lines, is presented. The four-channel photometer Oas installed at two high-apogee satellites of &apos;&apos;Prognoz-5&apos;&apos; and &apos;&apos;Prognoz-6&apos;&apos;. The sky scanning was performed due to satellite rotation around its axis directed to the Sun. A vessel with hydrogen was set up in the HILsub(..cap alpha..) channel in order to measure the Lsub(..cap alpha..) line width. All parameters connected with the Sun motion in interplanetary medium were determined.

  7. Pythagoras&apos;s theorem on a two-dimensional lattice from a &apos;natural&apos; Dirac operator and Connes&apos;s distance formula

    Energy Technology Data Exchange (ETDEWEB)

    Dai Jian [Theory Group, Department of Physics, Peking University, Beijing (China)]. E-mail: jdai@mail.phy.pku.edu.cn; Song Xingchang [Theory Group, Department of Physics, Peking University, Beijing (China)]. E-mail: songxc@ibm320h.phy.pku.edu.cn

    2001-07-13

    One of the key ingredients of Connes&apos;s noncommutative geometry is a generalized Dirac operator which induces a metric (Connes&apos;s distance) on the pure state space. We generalize such a Dirac operator devised by Dimakis et al, whose Connes distance recovers the linear distance on an one-dimensional lattice, to the two-dimensional case. This Dirac operator has the local eigenvalue property and induces a Euclidean distance on this two-dimensional lattice, which is referred to as &apos;natural&apos;. This kind of Dirac operator can be easily generalized into any higher-dimensional lattices. (author)

  8. Hot air instead of electricity. Special modular pumps at &apos;&apos;Saunaparadies Erding&apos;&apos;; Heissluft statt Elektrowaerme. Modulare Sonderpumpen im Saunaparadies Erding

    Energy Technology Data Exchange (ETDEWEB)

    Christoph, D. [Grundfos GmbH, Erkrath (Germany)

    2008-07-01

    &apos;&apos;Saunaparadies Erding&apos;&apos; is a sauna spa with 16 newly constructed saunas and with an uncommon heating concept. The investor opted for hot air instead of electric heating. Accordingly, an industrial-scale boiler was installed in the mechanical equipment room. The boiler supplies air of 170 degC to the air-to-water heat exchangers in the sauna cabins. The design of this system was a great challenge to the planners and constructors and also to the components of the piping system. (orig.)

  9. ApoER2 Controls Not Only Neuronal Migration in the Intermediate Zone But Also Termination of Migration in the Developing Cerebral Cortex.

    Science.gov (United States)

    Hirota, Yuki; Kubo, Ken-Ichiro; Fujino, Takahiro; Yamamoto, Tokuo T; Nakajima, Kazunori

    2016-11-30

    Neuronal migration contributes to the establishment of mammalian brain. The extracellular protein Reelin sends signals to various downstream molecules by binding to its receptors, the apolipoprotein E receptor 2 (ApoER2) and very low-density lipoprotein receptor and exerts essential roles in the neuronal migration and formation of the layered neocortex. However, the cellular and molecular functions of Reelin signaling in the cortical development are not yet fully understood. Here, to gain insight into the role of Reelin signaling during cortical development, we examined the migratory behavior of Apoer2-deficient neurons in the developing brain. Stage-specific labeling of newborn neurons revealed that the neurons ectopically invaded the marginal zone (MZ) and that neuronal migration of both early- and late-born neurons was disrupted in the intermediate zone (IZ) in the Apoer2 KO mice. Rescue experiments showed that ApoER2 functions both in cell-autonomous and noncell-autonomous manners, that Rap1, integrin, and Akt are involved in the termination of migration beneath the MZ, and that Akt also controls neuronal migration in the IZ downstream of ApoER2. These data indicate that ApoER2 controls multiple processes in neuronal migration, including the early stage of radial migration and termination of migration beneath the MZ in the developing neocortex.

  10. Adolescent male health.

    Science.gov (United States)

    Westwood, Michael; Pinzon, Jorge

    2008-01-01

    Although adolescent males have as many health issues and concerns as adolescent females, they are much less likely to be seen in a clinical setting. This is related to both individual factors and the health care system itself, which is not always encouraging and set up to provide comprehensive male health care. Working with adolescent boys involves gaining the knowledge and skills to address concerns such as puberty and sexuality, substance use, violence, risk-taking behaviours and mental health issues. The ability to engage the young male patient is critical, and the professional must be comfortable in initiating conversation about a wide array of topics with the teen boy, who may be reluctant to discuss his concerns. It is important to take every opportunity with adolescent boys to talk about issues beyond the presenting complain, and let them know about confidential care. The physician can educate teens about the importance of regular checkups, and that they are welcome to contact the physician if they are experiencing any concerns about their health or well-being. Parents of preadolescent and adolescent boys should be educated on the value of regular health maintenance visits for their sons beginning in their early teen years.

  11. Contributions to the qualification of the &apos;'CRISTAL'&apos; criticality calculi scheme: interpretation of critical experiments. Elaboration of a characterization system of neutronic configurations; Contributions a la qualification du schema de calcul de criticite &apos;'cristal'&apos;: interpretation d&apos;experiences critiques. Elaboration d&apos;un systeme de caracterisation des configurations neutroniques

    Energy Technology Data Exchange (ETDEWEB)

    Gagnier, E

    1999-06-01

    This thesis work is about the validation of the new criticality-safety package CRISTAL and contributes to the modernization and the improvement of the computational tools. The first part presents neutronic elements, the objectives of safety criticality studies and the package CRISTAL. Then, the validation work concerned two series of experiments involving uranyl solutions (UO{sub 2}F{sub 2}) and UO{sub 2} powders. For these experiments, the differences between the computation results and the experimental results were analysed. It was highlighted interesting physical phenomena such of the compensations of errors between the approximate representation by the 99 energy group structure on the first resonance of oxygen and the anisotropy of the diffusion simulation as well as the influence of uranium 234 in high enriched solutions in uranium 235. Once the work of the experimental qualification carried out, raises the question of the use the base of qualification and the &apos;'calculation-experiment'&apos; variations which are referred to it. It is often difficult to establish the link between the &apos;&apos;studied configuration&apos;&apos; and the experiments of the base of qualification. The presented characterisation system proposes to answer in a way automatic and quantified this difficulty: - in bringing an answer on the package qualification for the studied configuration, - in giving an estimate of the package bias. To answer these points, it was defined a set of 35 characteristic neutronic parameters representing the behaviour of the medium. To process the information brought by these parameters and to use it to answer the objectives of the system, we called upon statistical methods (Principal Components Analysis and Sliced Inverse Regression). The results obtained in the feasibility studies showed the relevance of these methods for the considered objectives. (author)

  12. Report of study group 4.1 &apos;&apos;pipeline ageing and rehabilitation&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Serena, L.

    2000-07-01

    This report describes the work on the subject &apos;pipeline ageing and rehabilitation&apos; carried out by the Study Group 4.1 and related to the triennium 1997 - 2000. The report is focused on ageing and rehabilitation of natural gas transmission pipelines and more in detail on the following topics: - Definition of pipeline ageing; - Different ageing elements; - Main causes of ageing; - Inspections and monitoring; - Repair methods on ageing pipelines; - Programmes and strategies for pipeline maintenance and rehabilitation. The report includes the state of the art of the different techniques used to assess pipeline ageing such as pig inspection, landslide areas monitoring as well as advanced monitoring methods used nowadays by pipeline operators; a clarification of the concepts for different maintenance approaches is also presented. In addition the report gives some information regarding repair methods in use, the methodologies to evaluate the defects and the philosophy on which each repair system is based. The remaining topics deal with the strategies of pipelines and coating rehabilitation, locus the attention in the economical and technical considerations also beyond the ageing concept and describe in details the main causes of ageing as indicated by operators. A questionnaire on these topics was in fact distributed and the obtained results are included in this report. (author)

  13. Why Was Kelvin&apos;s Estimate of the Earth&apos;s Age Wrong?

    Science.gov (United States)

    Lovatt, Ian; Syed, M. Qasim

    2014-01-01

    This is a companion to our previous paper in which we give a published example, based primarily on Perry&apos;s work, of a graph of ln "y" versus "t" when "y" is an exponential function of "t". This work led us to the idea that Lord Kelvin&apos;s (William Thomson&apos;s) estimate of the Earth&apos;s age was…

  14. Critical Pedagogy&apos;s Problem with Changing Teachers&apos; Dispositions towards Critical Teaching

    Science.gov (United States)

    Neumann, Jacob W.

    2013-01-01

    Increasing teachers&apos; dispositions towards critical teaching is a fundamental goal for critical pedagogy. Because critical educational change cannot occur without teachers&apos; "buy-in," developing teachers&apos; inclination to implement critical teaching into their classrooms is a prerequisite for any successful critical pedagogy…

  15. Individual Differences in Children&apos;s and Parents&apos; Generic Language

    Science.gov (United States)

    Gelman, Susan A.; Ware, Elizabeth A.; Kleinberg, Felicia; Manczak, Erika M.; Stilwell, Sarah M.

    2014-01-01

    Generics ("&apos;Dogs&apos; bark") convey important information about categories and facilitate children&apos;s learning. Two studies with parents and their 2- or 4-year-old children (N = 104 dyads) examined whether individual differences in generic language use are as follows: (a) stable over time, contexts, and domains, and (b) linked…

  16. BREF Information Sheet on &apos;&apos;Waste Treatment&apos;&apos;. Significance of European plant standards for mechanical biological waste treatment plants; BREF-Merkblatt &apos;'Abfallbehandlung'&apos;. Bedeutung europaeischer Anlagenstandards fuer die mechanisch-biologische Abfallbehandlung

    Energy Technology Data Exchange (ETDEWEB)

    Kalmbach, S. [Umweltbundesamt Dessau (Germany)

    2006-07-01

    The IVU Directive of the European Union of 1996 requires that all environmentally relevant industrial plants, this including waste disposal plants, must be equipped with the &apos;&apos;best available techniques&apos;&apos; (BAT). By 30 October 2007 at the latest this is also to apply for all existing plants. The pan-European exchange of information on best available techniques will be facilitated by Best Available Technique Reference (BREF) Notes as provided by the Sevilla Process. The present paper explains the significance of these documents for the member states and their use in Germany. It gives an overview of BREF work already completed or in progress. The author describes the &apos;&apos;Sevilla Process&apos;&apos; and the most important harmonisation outcomes for the BREF Note on &apos;&apos;Waste Treatment&apos;&apos;, which comprises chemical and physical treatment, mechanical biological treatment, preparation of refuse-derived fuels, slag processing, solvent recycling, and used oil recycling. He concludes with an outlook on the implementation of the BREF Notes.

  17. Teaching Laura Kipnis&apos;s "Love&apos;s Labors" in "Ways of Reading"

    Science.gov (United States)

    Fike, Matthew A.

    2013-01-01

    This essay describes a method of teaching a very challenging anthology piece: Laura Kipnis&apos;s "Love&apos;s Labors" (chapter 1 of her 2003 "Against Love: A Polemic"). The method, although designed for a critical thinking course, should also provide resources for those who teach Kipnis&apos;s work in writing courses. Using…

  18. Fossil sources: &apos;running out&apos; is not the problem

    Energy Technology Data Exchange (ETDEWEB)

    Scott, D.S. [University of Victoria, BC (Canada). Institute for Integrated Energy System

    2005-01-01

    In which we discuss reserves, resources and the mythology t